Aneurysm Type	Official Symbol	Gene ID	Description	Data Source	More Info	Clinical	Subcellular Location	Species
Abdominal aortic aneurysm	Ace	11421	the inhibitor can inhibit aneurysm	PMID: 19556720			"Angiotensin-converting enzyme, soluble form: Secreted.; Cell membrane ; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons."	mouse
Abdominal aortic aneurysm	Ace2	70008	KO can induce aneurysm	PMID: 25301841| PMID: 28935757			Processed angiotensin-converting enzyme 2: Secreted.; Cell membrane ; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons.	mouse
Abdominal aortic aneurysm	Adam17	11491	KO can inhibit aneurysm	PMID: 21722904			Isoform Long: Cell membrane; Single-pass type I membrane protein.; Isoform Short: Secreted.	mouse
Abdominal aortic aneurysm	Adora2a	11540	KO can induce aneurysm	PMID: 23413358			Cell membrane; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Agtr1a	11607	aortic tissue: KO can inhibit aneurysmincrease in RNA level	PMID: 22539767	AAA sexual dimorphism: AAAs exhibit marked sexual dimorphism with higher prevalence in men; AAAs induced by AngII infusion into mice exhibit a higher prevalence in males		Cell membrane; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Alox5	11689	KO can inhibit aneurysm	PMID: 25324573			"Cytoplasm. Nucleus matrix. Nucleus membrane ; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (By similarity).."	mouse
Abdominal aortic aneurysm	Ang	11727	AngII perfusion can promote the expansion of aneurysm| the blocker can inhibit aneurysm| Ang perfusion can induce aneurysm	PMID: 21763672| PMID: 19556720| PMID: 19252100			"Cytoplasm. Nucleus matrix. Nucleus membrane ; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (By similarity).."	mouse
Abdominal aortic aneurysm	Angpt2	11601	ANGPT2 perfusion can induce aneurysm| Ang II perfusion can induce aneurysm	PMID: 24480303| PMID: 11583973			Secreted.	mouse
Abdominal aortic aneurysm	Angptl2	26360	macrophages within the aortic aneurysmal vessel wall: increase in protein level	PMID: 22556334	familial aneurysm		Secreted.	mouse
Abdominal aortic aneurysm	Apoe	11816	KO can induce aneurysm	PMID: 28433630			Secreted.	mouse
Abdominal aortic aneurysm	Ar	11835	KO can inhibit aneurysmthe antagonist can inhibit aneurysm	PMID: 26817611			Nucleus. Cytoplasm. Note=Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1..	mouse
Abdominal aortic aneurysm	Arrb2	216869	KO can inhibit aneurysm	PMID: 23524589			"Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs."	mouse
Abdominal aortic aneurysm	Bdkrb2	12062	the antagonist can inhibit aneurysm	PMID: 26966276			Cell membrane; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Bgn	12111	KO can induce aneurysm	PMID: 25093698			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Capn2	12334	aorta: increase in protein level| the inhibitor can inhibit aneurysm	PMID: 23977256			Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding..	mouse
Abdominal aortic aneurysm	Cat	12359	overexpression can inhibit aneurysm	PMID: 21551275			Peroxisome.	mouse
Abdominal aortic aneurysm	Cav1	12389	KO can inhibit aneurysm	PMID: 24329494			"Golgi apparatus membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, caveola ; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).."	mouse
Abdominal aortic aneurysm	Cavin4	68016	KO can induce aneurysm	PMID: 28433630			"Cytoplasm, myofibril, sarcomere. Cytoplasm. Cytoplasm, cytosol. Membrane, caveola. Cell membrane, sarcolemma. Cell membrane. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm (PubMed:18332105). Localizes in the caveolae in a caveolin-dependent manner (PubMed:19546242).."	mouse
Abdominal aortic aneurysm	Ccl2	20296	KO can inhibit aneurysm	PMID: 19920349			Secreted.	mouse
Abdominal aortic aneurysm	Ccl5	20304	serum and aortic tissue: increase in protein levelincrease in RNA level| the inhibitor can inhibit aneurysm	PMID: 28982723| PMID: 23288157			Secreted.	mouse
Abdominal aortic aneurysm	Ccr2	12772	aorta: decrease in protein level| KO can inhibit aneurysm	PMID: 23393391| PMID: 22871590			"Cell membrane ; Multi-pass membrane protein. Note=The chemoattractant receptors are reportedly distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane.."	mouse
Abdominal aortic aneurysm	Cd14	12475	aorta: KO can inhibit aneurysmincrease in RNA level	PMID: 23537804	CD14 plays a crucial role in adventitial macrophage precursor recruitment early during AAA formation		"Cell membrane ; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor.."	mouse
Abdominal aortic aneurysm	Cd28	12487	KO can induce aneurysm	PMID: 23908246			Membrane; Single-pass type I membrane protein.	mouse
Abdominal aortic aneurysm	Cd4	12504	CD4+T cell deficiency can inhibit aneurysm	PMID: 14764734			Cell membrane ; Single-pass type I membrane protein.	mouse
Abdominal aortic aneurysm	Cd80	12519	KO can induce aneurysm	PMID: 23908246			Membrane; Single-pass type I membrane protein.	mouse
Abdominal aortic aneurysm	Cd86	12524	KO can induce aneurysm	PMID: 23908246			Cell membrane ; Single-pass type I membrane protein.	mouse
Abdominal aortic aneurysm	Cd8a	12525	CD8+T cell can induce aneurysm	PMID: 23585675			Cell membrane ; Single-pass type I membrane protein. Note=Cd8a localizes to lipid rafts only when associated with its partner Cd8b..	mouse
Abdominal aortic aneurysm	Cfp	18636	LOF mutation can inhibit aneurysm	PMID: 22308431			Secreted.	mouse
Abdominal aortic aneurysm	Col1a1	12842	KO can induce aneurysm	PMID: 19153555			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Col5a2	12832	KO can induce aneurysm	PMID: 28734943			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Cpb2	56373	KO can induce aneurysm	PMID: 20431069			Secreted.	mouse
Abdominal aortic aneurysm	Cst3	13010	KO can induce aneurysm| KO can promote artery dilation	PMID: 20472891| PMID: 15653570			Secreted.	mouse
Abdominal aortic aneurysm	Ctgf	14219	aorta: increase in protein level	PMID: 28562688			"Secreted, extracellular space, extracellular matrix. Secreted."	mouse
Abdominal aortic aneurysm	Ctsc	13032	LOF mutation can inhibit aneurysm	PMID: 17301245			Lysosome.	mouse
Abdominal aortic aneurysm	Ctsg	13035	KO can inhibit aneurysm	PMID: 25037606			Membrane. Note=Strongly associated with membranes.	mouse
Abdominal aortic aneurysm	Ctsk	13038	KO can inhibit aneurysm	PMID: 21817099			Lysosome.	mouse
Abdominal aortic aneurysm	Ctsl	13039	KO can inhibit aneurysm	PMID: 21868704			Lysosome.	mouse
Abdominal aortic aneurysm	Ctss	13040	AAA lesions: KO can inhibit aneurysmincrease in RNA level	PMID: 22871592			Lysosome.	mouse
Abdominal aortic aneurysm	Cxcl10	15945	KO can induce aneurysm	PMID: 19139386			Secreted.	mouse
Abdominal aortic aneurysm	Cxcr4	12767	KO can inhibit aneurysm	PMID: 24876351			"Cell membrane ; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).."	mouse
Abdominal aortic aneurysm	Cybb	13058	KO can inhibit aneurysm	PMID: 27912196			Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum..	mouse
Abdominal aortic aneurysm	Cyp19a1	13075	KO can induce aneurysm	PMID: 24582702		protective	Membrane; Peripheral membrane protein.	mouse
Abdominal aortic aneurysm	Cyp1b1	13078	KO can inhibit aneurysm	PMID: 27301358			Endoplasmic reticulum membrane ; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein. Mitochondrion.	mouse
Abdominal aortic aneurysm	Dcn	13179	aortic tissue: increase in protein level	PMID: 25781946			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Dpp4	13482	the inhibitor can inhibit aneurysm	PMID: 26549734			"Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid..; Cell membrane; Single-pass type II membrane protein. Apical cell membrane ; Single-pass type II membrane protein. Cell projection, invadopodium membrane ; Single-pass type II membrane protein. Cell projection, lamellipodium membrane ; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (By similarity).."	mouse
Abdominal aortic aneurysm	Egfr	13649	the inhibitor can prevent rupture of aneurysm	PMID: 25531554			"Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane ; Single-pass type I membrane protein. Nucleus membrane ; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).."	mouse
Abdominal aortic aneurysm	Hif1a	15251	KO can inhibit aneurysm| the inhibitor can inhibit aneurysm	PMID: 27497884| PMID: 27363580			"Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A isoform 2 in the nucleus and speckles (PubMed:21546903). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (By similarity).."	mouse
Abdominal aortic aneurysm	Hmox1	15368	KO can induce aneurysm	PMID: 27626316			Microsome. Endoplasmic reticulum membrane ; Peripheral membrane protein; Cytoplasmic side.	mouse
Abdominal aortic aneurysm	Hspa5	14828	aneurysmal areas: increase in protein level	PMID: 27889204			Endoplasmic reticulum lumen. Cytoplasm.	mouse
Abdominal aortic aneurysm	Ifng	15978	induce aneurysm in KOCD43 mice| KO can induce aneurysm| IFN-gamma can induce aneurysm	PMID: 23585675| PMID: 19139386| PMID: 14764734			Secreted.	mouse
Abdominal aortic aneurysm	Il1a	16175	the antagonist can inhibit aneurysm	PMID: 26941015			Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.	mouse
Abdominal aortic aneurysm	Il1b	16176	the antagonist can inhibit aneurysm| abdominal aortas: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 26941015| PMID: 23288154			"Cytoplasm, cytosol. Lysosome. Secreted, exosome. Cytoplasmic vesicle, autophagosome. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood. On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (By similarity). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (By similarity). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (PubMed:17641058). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (By similarity). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (PubMed:17284521). These mechanisms may not be not mutually exclusive.."	mouse
Abdominal aortic aneurysm	Il5	16191	aortic tissue: decrease in protein levelthe antibody can inhibit aneurysm	PMID: 22459292			Secreted.	mouse
Abdominal aortic aneurysm	Il6	16193	IL6 inhibitor (MR16-1) can inhibit AAA| aneurysm wall: increase in protein levelincrease in RNA level	PMID: 28982132| PMID: 27318834			Secreted.	mouse
Abdominal aortic aneurysm	Kit	16590	KO can inhibit aneurysm	PMID: 17932568			"Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Single-pass type I membrane protein.; Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.."	mouse
Abdominal aortic aneurysm	Klf4	16600	smooth muscle cells: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 24030402	KLF4 plays a critical role in aortic aneurysm formation via effects on smooth muscle cells (binds to promoters of SM genes)		Nucleus.	mouse
Abdominal aortic aneurysm	Klf5	12224	KO can inhibit aneurysm	PMID: 28115390			Nucleus.	mouse
Abdominal aortic aneurysm	Lcn2	16819	KO can inhibit aneurysm	PMID: 27229458			"Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized."	mouse
Abdominal aortic aneurysm	Lep	16846	induce aneurysm	PMID: 23220275			Secreted.	mouse
Abdominal aortic aneurysm	Lgals3	16854	serum and aortic tissue: increase in protein levelincrease in RNA level	PMID: 28982723			Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.	mouse
Abdominal aortic aneurysm	Lox	16948	inhibit the growth of aneurysm	PMID: 19683237			"Secreted. Secreted, extracellular space."	mouse
Abdominal aortic aneurysm	Mapk8	26419	the inhibitor can inhibit aneurysm	PMID: 16311603			Cytoplasm. Nucleus. Note=Colocalizes with POU5F1 in the nucleus..	mouse
Abdominal aortic aneurysm	Mcpt4	17227	KO can inhibit aneurysm	PMID: 19720934				mouse
Abdominal aortic aneurysm	Mmp14	17387	KO can induce aneurysm	PMID: 19010778			Membrane ; Single-pass type I membrane protein ; Extracellular side. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm..	mouse
Abdominal aortic aneurysm	Mmp2	17390	vascular wall smooth muscle cells: increase in RNA level| KO can aggravate aneurysm	PMID: 22357537| PMID: 23144462			"Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity)..; Isoform 2: Cytoplasm. Mitochondrion."	mouse
Abdominal aortic aneurysm	Mmp9	17395	KO can inhibit aneurysm	PMID: 10841523			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Mpo	17523	serum: KO can inhibit aneurysm| increase in protein level	PMID: 28971841			Lysosome.	mouse
Abdominal aortic aneurysm	mt-Co2	17709	the inhibitor can inhibit aneurysm| KO can inhibit aneurysm	PMID: 23209546| PMID: 17137566			Mitochondrion inner membrane.	mouse
Abdominal aortic aneurysm	Myd88	17874	KO can inhibit aneurysm	PMID: 21960563			Cytoplasm. Nucleus.	mouse
Abdominal aortic aneurysm	Ncf1	17969	KO can inhibit aneurysm	PMID: 16864727			"Cytoplasm, cytosol. Membrane ; Peripheral membrane protein ; Cytoplasmic side."	mouse
Abdominal aortic aneurysm	Nf1	18015	KO can induce aneurysm	PMID: 24370551			"Nucleus. Nucleus, nucleolus."	mouse
Abdominal aortic aneurysm	Nos3	18127	KO the cofactor can induce aneurysm	PMID: 22083158			"Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.."	mouse
Abdominal aortic aneurysm	Notch1	18128	aortic aneurysmal tissue: KO can inhibit aneurysm| decrease in protein level| decrease in RNA level| the inhibitor can inhibit progress of aneurysm	PMID: 23087364| PMID: 28562688| PMID: 25349182			Cell membrane ; Single-pass type I membrane protein.; Notch 1 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10..	mouse
Abdominal aortic aneurysm	Nov	18133	overexpression can induce aneurysm	PMID: 26974158			"Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the Gap junction in presence of GJA1/CX43.."	mouse
Abdominal aortic aneurysm	Nox1	237038	KO can inhibit aneurysm	PMID: 27912196			"Cell projection, invadopodium membrane ; Multi-pass membrane protein. Cell membrane."	mouse
Abdominal aortic aneurysm	Nox4	50490	KO can inhibit aneurysm	PMID: 27912196			"Endoplasmic reticulum membrane ; Multi-pass membrane protein. Cell junction, focal adhesion. Cell membrane. Note=May localize to plasma membrane and focal adhesions.."	mouse
Abdominal aortic aneurysm	P2ry13	74191	aneurysmal areas: increase in protein level	PMID: 27889204			Cell membrane.	mouse
Abdominal aortic aneurysm	Pcsk9	100102	D377Y	PMID: 27470509			Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and co-localizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity)..	mouse
Abdominal aortic aneurysm	Pf4	56744	the inhibitor can inhibit aneurysm	PMID: 23288157			Secreted.	mouse
Abdominal aortic aneurysm	Pla2g10	26565	abdominal aorta: increase in protein level| KO can inhibit aneurysm	PMID: 20833395| PMID: 21984544	Group X secretory phospholipase A(2) promotes Ang II-induced pathological responses leading to AAA formation		Secreted.	mouse
Abdominal aortic aneurysm	Plau	18792	KO can inhibit aneurysm	PMID: 12600880			Secreted.	mouse
Abdominal aortic aneurysm	Pltp	18830	KO can inhibit aneurysm	PMID: 23830874			Secreted.	mouse
Abdominal aortic aneurysm	Pparg	19016	KO can induce aneurysm	PMID: 20630681			Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (By similarity). NOCT enhances its nuclear translocation..	mouse
Abdominal aortic aneurysm	Prkaa1	105787	vascular smooth muscle cells: increase in protein level	PMID: 28179583			"Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters."	mouse
Abdominal aortic aneurysm	Prkaa2	108079	KO can inhibit aneurysm	PMID: 22561688			"Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters."	mouse
Abdominal aortic aneurysm	Prkcd	18753	KO can inhibit aneurysm	PMID: 22879584			"Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell membrane ; Peripheral membrane protein."	mouse
Abdominal aortic aneurysm	Pten	19211	vascular wall smooth muscle cells: decrease in RNA level	PMID: 22357537			"Cytoplasm. Nucleus. Nucleus, PML body. Note=Monoubiquitinated form is nuclear (By similarity). Nonubiquitinated form is cytoplasmic (By similarity). Colocalized with PML and USP7 in PML nuclear bodies (By similarity). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982).."	mouse
Abdominal aortic aneurysm	Ptger4	19219	aortas: increase in protein levelthe antagonist can inhibit aneurysm| KO can induce aneurysm	PMID: 22595380| PMID: 21088251			Cell membrane; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Ptges	64292	KO can inhibit aneurysm	PMID: 18285567			Membrane ; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Retnlb	57263	increase in protein levelincrease in RNA level	PMID: 25479529			Secreted.	mouse
Abdominal aortic aneurysm	Ripk3	56532	arterial wall: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 25563840			"Cytoplasm, cytosol. Cell membrane. Mitochondrion."	mouse
Abdominal aortic aneurysm	Sdc1	20969	KO can induce aneurysm	PMID: 22173227			"Membrane ; Single-pass type I membrane protein. Secreted. Secreted, exosome. Note=Shedding of the ectodomain produces a soluble form.."	mouse
Abdominal aortic aneurysm	Sell	20343	aortas: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 15998669			Cell membrane ; Single-pass type I membrane protein.	mouse
Abdominal aortic aneurysm	Serpine1	18787	KO can induce aneurysm	PMID: 22307671			Secreted.	mouse
Abdominal aortic aneurysm	Smad3	17127	KO can lead to vascular remodeling	PMID: 25985281			"Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta.."	mouse
Abdominal aortic aneurysm	Stat3	20848	the inhibitor can inhibit aneurysm	PMID: 26299839			"Cytoplasm. Nucleus. Note=Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.."	mouse
Abdominal aortic aneurysm	Tert	21752	KO can inhibit aneurysm	PMID: 21088250			"Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body. Note=Shuttling between nuclear and cytoplasm depends on cell cycle, phosphorylation states, transformation and DNA damage. Diffuse localization in the nucleoplasm. Enriched in nucleoli of certain cell types. Translocated to the cytoplasm via nuclear pores in a CRM1/RAN-dependent manner involving oxidative stress-mediated phosphorylation at Tyr-697. Dephosphorylation at this site by SHP2 retains TERT in the nucleus. Translocated to the nucleus by phosphorylation by AKT (By similarity).."	mouse
Abdominal aortic aneurysm	Tfap2a	21418	vascular smooth muscle cells: increase in protein level	PMID: 28179583			Nucleus.	mouse
Abdominal aortic aneurysm	Tgfbr1	21812	overexpression can induce aneurysm	PMID: 24355923			"Cell membrane ; Single-pass type I membrane protein. Cell junction, tight junction. Membrane raft. Cell surface."	mouse
Abdominal aortic aneurysm	Tgfbr2	21813	KO can inhibit aneurysm| overexpression can induce aneurysm	PMID: 25450370| PMID: 24355923			Cell membrane ; Single-pass type I membrane protein. Membrane raft.	mouse
Abdominal aortic aneurysm	Thbs1	21825	aortas: KO can inhibit aneurysm| increase in protein level	PMID: 25940549			"Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum. Note=Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (By similarity). Incorporated into the extracellular matrix of fibroblasts (By similarity). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (PubMed:22682248).."	mouse
Abdominal aortic aneurysm	Timp1	21857	aortic tissue: increase in protein levelincrease in RNA level| KO can induce aneurysm	PMID: 24279124| PMID: 15680392			Secreted.	mouse
Abdominal aortic aneurysm	Timp3	21859	KO can induce aneurysm	PMID: 23144462			"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Tlr2	24088	KO can inhibit aneurysm	PMID: 23412709			"Cell membrane ; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.."	mouse
Abdominal aortic aneurysm	Tlr4	21898	KO can inhibit aneurysm	PMID: 26299839			"Cell membrane ; Single-pass type I membrane protein. Early endosome. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.."	mouse
Abdominal aortic aneurysm	Tnc	21923	aortic tissue: increase in protein level	PMID: 21951663	the rapid expansion of AAA coincided with a high expression of TN‐C in the aortic tissue	progress and prognosis (may serve as a clinical biomarker for disease activity in AAA)	"Secreted, extracellular space, extracellular matrix."	mouse
Abdominal aortic aneurysm	Tnf	21926	aneurysm tissue: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 19620291			"Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor, membrane form: Membrane ; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted."	mouse
Abdominal aortic aneurysm	Tnfsf10	22035	media: increase in protein level	PMID: 26783750			Cell membrane ; Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form..	mouse
Abdominal aortic aneurysm	Ucp2	22228	vascular tissue: increase in protein levelincrease in RNA level	PMID: 28683125			Mitochondrion inner membrane ; Multi-pass membrane protein.	mouse
Abdominal aortic aneurysm	Vdr	22337	VDR perfusion can inhibit aneurysm	PMID: 27283745			Nucleus. Cytoplasm. Note=Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3..	mouse
Abdominal aortic aneurysm	Vegfa	22339	aortic wall: increase in RNA leveluse the receptor (sFlt-1) can inhibit aneurysm	PMID: 21436157			Isoform VEGF-1: Secreted.; Isoform VEGF-2: Secreted.; Isoform VEGF-3: Cell membrane; Peripheral membrane protein. Note=Remains cell-surface associated unless released by heparin.	mouse
Aneurysm	Efemp2	58859	KO can induce aneurysm	PMID: 16478991			Secreted.	mouse
Aneurysm	Ldlr	16835	overexpression can induce aneurysm	PMID: 12690199			"Cell membrane ; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome. Note=Rapidly endocytosed upon ligand binding.."	mouse
Aneurysm	Lrp1	16971	inactivation can induce aneurysm	PMID: 12690199			"Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane ; Single-pass type I membrane protein. Membrane, coated pit.; Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane ; Peripheral membrane protein ; Extracellular side. Membrane, coated pit.; Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.."	mouse
Aneurysm	Rcan1	54720	KO can inhibit aneurysm	PMID: 21930771				mouse
Aneurysm	Srf	20807	KO can induce aneurysm	PMID: 18804439			Nucleus.	mouse
Aneurysm	Tgfbr2	21813	KO can induce aneurysm	PMID: 19165826			Cell membrane ; Single-pass type I membrane protein. Membrane raft.	mouse
Aneurysm of heart	Nkx2-5	18091	haploinsufficiency can induce aneurysm	PMID: 11073884	septal aneurysm		Nucleus.	mouse
"Aneurysm, false"	Timp1	21857	KO can induce pseudo-aneurysm	PMID: 12538437			Secreted.	mouse
Aortic aneurysm	Ace	11421	smooth muscle cell: increase in RNA level	PMID: 23636094	ascending AA		"Angiotensin-converting enzyme, soluble form: Secreted.; Cell membrane ; Single-pass type I membrane protein. Cytoplasm. Note=Detected in both cell membrane and cytoplasm in neurons."	mouse
Aortic aneurysm	Agtr1a	11607	KO can inhibit aneurysm	PMID: 21252156	ascending AA		Cell membrane.	mouse
Aortic aneurysm	Ang	11727	smooth muscle cell: increase in RNA level	PMID: 23636094	ascending AA		"Cytoplasmic vesicle, secretory vesicle lumen. Secreted. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).."	mouse
Aortic aneurysm	Apoe	11816	KO can induce aneurysm	PMID: 19618151			Secreted.	mouse
Aortic aneurysm	Bdkrb1	12061	serum: KO can induce aneurysmincrease in RNA level	PMID: 19618151			Cell membrane; Multi-pass membrane protein.	mouse
Aortic aneurysm	Cdkn2b	12579	KO can induce aneurysm	PMID: 23162013				mouse
Aortic aneurysm	Cxcr3	12766	KO can inhibit aneurysm	PMID: 21962843			Cell membrane ; Multi-pass membrane protein.	mouse
Aortic aneurysm	Efemp2	58859	KO can induce aneurysm| E57K 	PMID: 23636094| PMID: 26178373	ascending AA		Secreted.	mouse
Aortic aneurysm	Il1r1	16177	KO can induce aneurysm	PMID: 22245214	familial aneurysm		Membrane; Single-pass type I membrane protein. Cell membrane. Secreted.	mouse
Aortic aneurysm	Il6	16193	aorta: KO can inhibit aneurysmincrease in RNA level	PMID: 24449804	ascending AA		Secreted.	mouse
Aortic aneurysm	Ilk	16202	KO can induce aneurysm	PMID: 23744273			"Cell junction, focal adhesion. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, myofibril, sarcomere. Cell projection, lamellipodium."	mouse
Aortic aneurysm	Klf15	66277	KO can induce aneurysm	PMID: 20375365			Nucleus.	mouse
Aortic aneurysm	Lox	16948	KO can induce aneurysm	PMID: 12417550			"Secreted. Secreted, extracellular space."	mouse
Aortic aneurysm	Mapk1	26413	the inhibitor can inhibit aneurysm	PMID: 21493862			"Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser-244 and Ser-246 as well as autophosphorylation at Thr-188 promote nuclear localization (By similarity).."	mouse
Aortic aneurysm	Mapk3	26417	the inhibitor can inhibit aneurysm	PMID: 21493862			"Cytoplasm. Nucleus. Membrane, caveola. Note=Autophosphorylation at Thr-207 promotes nuclear localization (By similarity). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm.."	mouse
Aortic aneurysm	Mmp12	17381	KO can inhibit aneurysm	PMID: 15800495			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic aneurysm	Mmp9	17395	aortic arch: increase in protein level	PMID: 20592247			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic aneurysm	Nf1	18015	KO can inhibit aneurysm	PMID: 24370551			"Nucleus. Nucleus, nucleolus."	mouse
Aortic aneurysm	Pik3cd	18707	D910A	PMID: 25503990			Cytoplasm.	mouse
Aortic aneurysm	Plau	18792	overexpression can induce aneurysm| KO can inhibit aneurysm	PMID: 21536666| PMID: 9398846			Secreted.	mouse
Aortic aneurysm	Ppia	268373	KO can inhibit aneurysm	PMID: 19430489			"Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.."	mouse
Aortic aneurysm	Ptges	64292	KO can inhibit aneurysm	PMID: 21282500			Membrane ; Multi-pass membrane protein.	mouse
Aortic aneurysm	S100a9	20202	macrophage: increase in protein levelincrease in RNA level	PMID: 21536666			"Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway."	mouse
Aortic aneurysm	Selp	20344	KO can inhibit aneurysm	PMID: 17182955			Cell membrane ; Single-pass type I membrane protein.	mouse
Aortic aneurysm	Smad3	17127	KO can promote aneurysm	PMID: 27688095			"Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta.."	mouse
Aortic aneurysm	Smad4	17128	KO can aggravate aneurysm	PMID: 21493862			Cytoplasm. Nucleus. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation..	mouse
Aortic aneurysm	Socs3	12702	aorta: increase in RNA level| overexpression can induce aneurysm	PMID: 24449804| PMID: 23329138	ascending AA			mouse
Aortic aneurysm	Stat3	20848	inhibit the pathway can induce aneurysm	PMID: 23329138			"Cytoplasm. Nucleus. Note=Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation.."	mouse
Aortic aneurysm	Tgfb1	21803	overexpression can inhibit aneurysm	PMID: 19325140			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic aneurysm	Thbs4	21828	KO can induce aneurysm	PMID: 26968543			"Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix."	mouse
Aortic aneurysm	Xbp1	22433	KO can induce aneurysm	PMID: 29089350			"Endoplasmic reticulum. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity)..; Isoform 1: Nucleus. Cytoplasm. Endoplasmic reticulum membrane ; Single-pass type II membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Membrane ; Peripheral membrane protein. Note=Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (By similarity). Shows no preferential localization to either the nucleus or the cytoplasm (PubMed:16332684)..; Isoform 2: Nucleus. Cytoplasm. Note=Localizes predominantly in the nucleus (PubMed:16332684). Colocalizes in the nucleus with SIRT1 (PubMed:20955178). Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (PubMed:20348926)..; X-box-binding protein 1, cytoplasmic form: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (By similarity).."	mouse
Aortic aneurysm and dissection	Adamts4	240913	KO can inhibit aneurysm	PMID: 28955046			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic aneurysm and dissection	Akt2	11652	KO can induce aneurysm	PMID: 23250987		protective	"Cytoplasm. Nucleus. Cell membrane ; Peripheral membrane protein. Early endosome. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (PubMed:20189988).."	mouse
Aortic aneurysm and dissection	Cyld	74256	KO can induce aneurysm	PMID: 28751569			"Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=Detected at the microtubule cytoskeleton during interphase (By similarity). Detected at the midbody during telophase (By similarity). During metaphase, it remains localized to the centrosome but is also present along the spindle (By similarity).."	mouse
Aortic aneurysm and dissection	Efemp2	58859	KO can induce aneurysm	PMID: 21858106			Secreted.	mouse
Aortic aneurysm and dissection	Efnb2	13642	KO can induce aneurysm	PMID: 12149214			Membrane; Single-pass type I membrane protein.	mouse
Aortic aneurysm and dissection	Nos3	18127	KO can induce aneurysm	PMID: 11468208			"Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.."	mouse
Aortic aneurysm and dissection	Stat1	20846	aortic wall: increase in protein level	PMID: 20347693			"Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus. Translocates into the nucleus in response to interferon-beta stimulation.."	mouse
Aortic Dissection	Agt	11606	induce aneurysm	PMID: 23136157	acute AD		Secreted.	mouse
Aortic Dissection	Bgn	12111	KO can induce aneurysm	PMID: 17502576			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic Dissection	Col1a1	12842	INT1 del can induce dissection	PMID: 14630726			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic Dissection	Col3a1	12825	haploinsufficiency can induce AD	PMID: 21071432			"Secreted, extracellular space, extracellular matrix."	mouse
Aortic Dissection	Cybb	13058	overexpression can induce aneurysm	PMID: 24807872			Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum..	mouse
Aortic Dissection	Fbn1	14118	KO can induce MFS	PMID: 10097121			"Secreted. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin..; Asprosin: Secreted. Note=Secreted into the plasma..; Fibrillin-1: Secreted, extracellular space, extracellular matrix."	mouse
Aortic Dissection	Mmp9	17395	KO can inhibit AD	PMID: 23136157	acute AD		"Secreted, extracellular space, extracellular matrix."	mouse
Aortic Dissection	Nox1	237038	KO can inhibit aneurysm	PMID: 17502491			"Cell projection, invadopodium membrane ; Multi-pass membrane protein. Cell membrane."	mouse
Aortic Dissection	Pkd1	18763	aorta: decrease in RNA level	PMID: 17656674			"Cell membrane ; Multi-pass membrane protein. Cell projection, cilium. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autocatalytic cleavage at the GPS domain (PubMed:12514735). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (PubMed:24939912). Cell surface localization requires GANAB (By similarity).."	mouse
Aortic Dissection	Ptgfr	19220	the antagonist can induce aneurysm	PMID: 25341845			Cell membrane; Multi-pass membrane protein.	mouse
Carotid aneurysm	Ccl2	20296	induce aneurysm when at high concentration	PMID: 22007074			Secreted.	mouse
Carotid aneurysm	Hp	15439	HP2-2 genotype can induce aneurysm	PMID: 23096414	carotid artery aneurysms		Secreted.	mouse
Carotid aneurysm	Nos3	18127	KO can inhibit aneurysm	PMID: 18182824	in aged mice		"Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.."	mouse
Carotid aneurysm	Tnf	21926	the blocker can inhibit aneurysm	PMID: 16670341			"Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor, membrane form: Membrane ; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted."	mouse
Cerebral aneurysm	Ccl2	20296	aneurysmal wall: KO can inhibit aneurysm| increase in protein level| increase in RNA level	PMID: 19164781			Secreted.	mouse
Cerebral aneurysm	Elane	50701	Elastase perfusion can induce IA	PMID: 19884566				mouse
Cerebral aneurysm	Il1b	16176	KO can inhibit aneurysm	PMID: 16439700			"Cytoplasm, cytosol. Lysosome. Secreted, exosome. Cytoplasmic vesicle, autophagosome. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood. On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (By similarity). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (By similarity). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (PubMed:17641058). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (By similarity). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (PubMed:17284521). These mechanisms may not be not mutually exclusive.."	mouse
Cerebral aneurysm	Mmp9	17395	KO can inhibit aneurysm	PMID: 19884566			"Secreted, extracellular space, extracellular matrix."	mouse
Cerebral aneurysm	Ncf1	17969	aneurysmal wall: KO can inhibit aneurysmincrease in RNA level	PMID: 19381132			"Cytoplasm, cytosol. Membrane ; Peripheral membrane protein ; Cytoplasmic side."	mouse
Cerebral aneurysm	Nfkb1	18033	KO can inhibit aneurysm	PMID: 28174280			"Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).; Isoform 5: Cytoplasm.; Isoform 6: Nucleus. Cytoplasm.; Isoform 7: Nucleus."	mouse
Cerebral aneurysm	Nos2	18126	KO can inhibit growth of aneurysm	PMID: 14615616				mouse
Cerebral aneurysm	Nos3	18127	KO can induce aneurysm	PMID: 17691969			"Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.."	mouse
Cerebral aneurysm	Pparg	19016	the activator can prevent rupture of aneurysm	PMID: 25931465			Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (By similarity). NOCT enhances its nuclear translocation..	mouse
Cerebral aneurysm	Ptger2	19217	KO can inhibit aneurysm	PMID: 28174280			Cell membrane; Multi-pass membrane protein.	mouse
Cerebral aneurysm	Ptges	64292	KO can lead to worse prognosis	PMID: 26134597			Membrane ; Multi-pass membrane protein.	mouse
Cerebral aneurysm	Ptgfr	19220	the antagonist can induce aneurysm	PMID: 25341845			Cell membrane; Multi-pass membrane protein.	mouse
Cerebral aneurysm	Rag1	19373	inhibit the aneurysm	PMID: 27416931			Nucleus.	mouse
Cerebral aneurysm	Sox17	20671	endothelial cells of normal intracerebral arteries: del| decrease in protein level	PMID: 25596186			Nucleus.	mouse
Cerebral aneurysm	Timp1	21857	smooth muscle cells in aneurysmal walls: KO can induce aneurysmincrease in RNA level	PMID: 17569872			Secreted.	mouse
Cerebral aneurysm	Timp2	21858	smooth muscle cells in aneurysmal walls: KO can induce aneurysmincrease in RNA level	PMID: 17569872			Secreted.	mouse
Cerebral aneurysm	Tnf	21926	KO can inhibit aneurysm| the inhibitor can inhibit aneurysm	PMID: 24739142			"Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor, membrane form: Membrane ; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted."	mouse
Kawasaki disease	Mmp9	17395	coronary artery : KO can inhibit the degradation of elastin protein| increase in protein level| increase in RNA level	PMID: 18311803			"Secreted, extracellular space, extracellular matrix."	mouse
Marfan syndrome	Eln	13717	aortic smooth muscle cells: decrease in protein level	PMID: 29040313			"Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.."	mouse
Marfan syndrome	Fbn1	14118	GxxPG motifs| C1039G/+| mutation can induce MFS	PMID: 23100322| PMID: 17641224| PMID: 9326947			"Secreted. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin..; Asprosin: Secreted. Note=Secreted into the plasma..; Fibrillin-1: Secreted, extracellular space, extracellular matrix."	mouse
Marfan syndrome	Klf4	16600	overexpression can inhibit MFS	PMID: 29040313			Nucleus.	mouse
Marfan syndrome	Ltbp3	16998	KO can improve the prognosis of MFS	PMID: 26494287			Secreted. Note=Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide.	mouse
Marfan syndrome	Mmp2	17390	aortic smooth muscle cells: increase in protein level	PMID: 29040313			"Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity)..; Isoform 2: Cytoplasm. Mitochondrion."	mouse
Marfan syndrome	Mmp9	17395	aortic smooth muscle cells: increase in protein level	PMID: 29040313			"Secreted, extracellular space, extracellular matrix."	mouse
Marfan syndrome	Tgfbr2	21813	R528C (1582C>T);  T315M; K291K (873C>T )| KO can induce aneurysm	PMID: 20144264| PMID: 24401272			Cell membrane ; Single-pass type I membrane protein. Membrane raft.	mouse
Microaneurysm	Pdgfb	18591	KO can induce aneurysm	PMID: 9211853			Secreted. Note=Released by platelets upon wounding..	mouse
Thoracic aortic aneurysm	Agtr2	11609	the antagonist can induce aneurysm	PMID: 23593499			Cell membrane ; Multi-pass membrane protein.	mouse
Thoracic aortic aneurysm	Arhgap18	73910	"aortic tissue: decrese in mRNA level, decrease in protein level; KO can induce aneurysm "	PMID: 28701309	Arhgap18 deletion exacerbated TAA formation	protective	Cytoplasm.	mouse
Thoracic aortic aneurysm	Ctgf	14219	proximal aorta: increase in protein level	PMID: 23985903			"Secreted, extracellular space, extracellular matrix. Secreted."	mouse
Thoracic aortic aneurysm	Ilk	16202	KO can induce aneurysm	PMID: 21778429			"Cell junction, focal adhesion. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, myofibril, sarcomere. Cell projection, lamellipodium."	mouse
Thoracic aortic aneurysm	Mmp14	17387	descending thoracic aortas: increase in protein levelincrease in RNA level	PMID: 20418476			Membrane ; Single-pass type I membrane protein ; Extracellular side. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm..	mouse
Thoracic aortic aneurysm	Mmp2	17390	descending thoracic aortas: increase in protein levelincrease in RNA level| serum: increase in protein levelincrease in RNA level| KO can inhibit aneurysm	PMID: 20418476| PMID: 17641224| PMID: 16159824			"Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity)..; Isoform 2: Cytoplasm. Mitochondrion."	mouse
Thoracic aortic aneurysm	Mmp9	17395	serum: increase in protein levelincrease in RNA level| KO can inhibit aneurysm	PMID: 17641224| PMID: 16159824			"Secreted, extracellular space, extracellular matrix."	mouse
Thoracic aortic aneurysm	Smad2	17126	KO can induce aneurysm	PMID: 25238995			"Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.."	mouse
Thoracic aortic aneurysm	Smad3	17127	KO can induce aneurysm	PMID: 25238995			"Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta.."	mouse
Thoracic aortic aneurysm	Timp1	21857	KO can induce aneurysm	PMID: 15364874			Secreted.	mouse
Thoracic aortic aneurysm and dissection	Ddit3	13198	KO can inhibit aneurysm	PMID: 25788370			Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.	mouse
Thoracic aortic aneurysm and dissection	Mmp2	17390	KO can induce aneurysm	PMID: 25657308			"Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity)..; Isoform 2: Cytoplasm. Mitochondrion."	mouse
Thoracic aortic aneurysm and dissection	Myocd	214384	KO can induce aneurysm	PMID: 25805819			"Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei."	mouse
Thoracic aortic aneurysm and dissection	P2ry12	70839	KO can inhibit aneurysm	PMID: 27534720			Cell membrane; Multi-pass membrane protein.	mouse
Thoracic aortic dissection	Angpt2	11601	aortic tissue: increase in protein level	PMID: 23630948			Secreted.	mouse
Thoracic aortic dissection	Col3a1	12825	KO can induce aneurysm	PMID: 23630948			"Secreted, extracellular space, extracellular matrix."	mouse