Aneurysm Type Official Symbol Gene ID Description Data Source More Info Clinical Subcellular Location Species Abdominal aortic aneurysm Agtr1a 24180 abdominal aorta: increase in RNA level| DHT can induce aneurysm PMID: 18451329 Cell membrane. rat Abdominal aortic aneurysm Alox5 25290 KO can inhibit aneurysm PMID: 17182931 "Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-271. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association." rat Abdominal aortic aneurysm Anxa2 56611 aneurysm intima: increase in protein level| increase in RNA level PMID: 19756921 "Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane." rat Abdominal aortic aneurysm Apoe 25728 genotype (E3E3 & E3E4) can affect the expansion of aneurysm PMID: 10848855 Secreted. rat Abdominal aortic aneurysm C5ar1 113959 the antagonist can inhibit aneurysm PMID: 14718840 Cell membrane ; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.. rat Abdominal aortic aneurysm Cav1 25404 KO can inhibit aneurysm PMID: 24329494 elastic lamina (RIEL) "Golgi apparatus membrane ; Peripheral membrane protein. Cell membrane ; Peripheral membrane protein. Membrane, caveola ; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae." rat Abdominal aortic aneurysm Ccl2 24770 anterior sac/aneurysm wall: increase in RNA level PMID: 16809548 Secreted. rat Abdominal aortic aneurysm Cxcr4 60628 BMSCs: increase in protein level| increase in RNA level PMID: 24751384 "Cell membrane ; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).." rat Abdominal aortic aneurysm Cyld 312937 KO can inhibit aneurysm PMID: 28751569 "Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=Detected at the microtubule cytoskeleton during interphase (By similarity). Detected at the midbody during telophase (By similarity). During metaphase, it remains localized to the centrosome but is also present along the spindle (By similarity).." rat Abdominal aortic aneurysm Des 64362 aortic wall: decrease in protein level PMID: 10965315 "Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma. Nucleus. Note=Localizes in the intercalated disks which occur at the Z line of cardiomyocytes. Localizes in the nucleus exclusively in differentiating cardiac progenitor cells and premature cardiomyocytes.." rat Abdominal aortic aneurysm Ehf 295965 the inhibitor can inhibit aneurysm PMID: 14662712 "Secreted, extracellular space." rat Abdominal aortic aneurysm Il1 24494 aorta: increase in RNA level PMID: 20615646 "Secreted. Secreted, extracellular space." rat Abdominal aortic aneurysm Kng1 288001 point mutation PMID: 15238617 rat Abdominal aortic aneurysm Lox 24914 aortic wall: decrease in RNA level PMID: 10965315 Secreted. Extracellular space. rat Abdominal aortic aneurysm Mmp1 300339 aorta: increase in protein level PMID: 11877705 "Secreted, extracellular space, extracellular matrix." rat Abdominal aortic aneurysm Mmp12 117033 aorta: increase in protein level PMID: 11877705 "Secreted, extracellular space, extracellular matrix." rat Abdominal aortic aneurysm Mmp14 81707 aorta: increase in protein level PMID: 11877705 Membrane ; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.. rat Abdominal aortic aneurysm Mmp2 81686 RASMC: increase in protein level| aorta: increase in RNA level| aorta/aneurysms: increase in protein level PMID: 25537973| PMID: 20615646| PMID: 21039990 rat aortic vascular smooth muscle cells (RASMC) "Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).." rat Abdominal aortic aneurysm Mmp9 81687 RASMC: increase in protein level| aorta: increase in RNA level| aorta/aneurysms: increase in protein level| aorta: increase in protein level PMID: 25537973| PMID: 20615646| PMID: 21039990| PMID: 11877705 rat aortic vascular smooth muscle cells (RASMC) "Secreted, extracellular space, extracellular matrix." rat Abdominal aortic aneurysm Nfkb1 81736 the inhibitor can inhibit aneurysm PMID: 14662712 "Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).." rat Abdominal aortic aneurysm Nos3 24600 aorta: increase in protein level| the inhibitor can inhibit aneurysm PMID: 15800493 "Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity.." rat Abdominal aortic aneurysm Nox4 85431 upregulation of NOX4 can induce aneurysm PMID: 28751569 "Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein. Cell junction, focal adhesion. Note=May localize to plasma membrane and focal adhesions." rat Abdominal aortic aneurysm P2ry12 64803 the antagonist can inhibit aneurysm PMID: 19028049 Cell membrane ; Multi-pass membrane protein. rat Abdominal aortic aneurysm Pc 25104 aortic wall: increase in RNA level PMID: 10965315 Mitochondrion matrix. rat Abdominal aortic aneurysm Pi15 301489 RIEL of the abdominal aorta: decrease in RNA level PMID: 24790086 internal elastic lamina (RIEL) Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation (By similarity).. rat Abdominal aortic aneurysm Postn 361945 RASMC: increase in protein level PMID: 24260297 rat aortic vascular smooth muscle cells (RASMC) rat Abdominal aortic aneurysm Pparg 25664 KO can induce aneurysm PMID: 20630681 Nucleus. Cytoplasm. rat Abdominal aortic aneurysm Ptger4 84023 the antagonist can inhibit aneurysm PMID: 22570740 Cell membrane; Multi-pass membrane protein. rat Abdominal aortic aneurysm Reck 313488 abdominal aortic endothelium: decrease in RNA level PMID: 24812324 rat Abdominal aortic aneurysm Serpine1 24617 overexpression can inhibit aneurysm PMID: 20554458 Secreted. rat Abdominal aortic aneurysm Tgfb1 59086 overexpression can inhibit aneurysm PMID: 16103255 "Secreted, extracellular space, extracellular matrix." rat Abdominal aortic aneurysm Timp1 116510 aorta: increase in RNA level| overexpression can inhibit aneurysm PMID: 20615646| PMID: 20554458 Secreted. rat Abdominal aortic aneurysm Timp2 29543 aorta: increase in RNA level| overexpression can inhibit aneurysm PMID: 20615646| PMID: 20103929 Secreted. rat Abdominal aortic aneurysm Timp3 25358 abdominal aortic endothelium: decrease in RNA level PMID: 24812324 "Secreted, extracellular space, extracellular matrix." rat Abdominal aortic aneurysm Tnf 24835 aorta: increase in RNA level PMID: 20615646 "Cell membrane ; Single-pass type II membrane protein.; Tumor necrosis factor, membrane form: Membrane ; Single-pass type II membrane protein.; Tumor necrosis factor, soluble form: Secreted.; C-domain 1: Secreted.; C-domain 2: Secreted." rat Abdominal aortic aneurysm Vim 81818 anterior sac/aneurysm wall: increase in RNA level PMID: 16809548 "Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix." rat Aneurysm Serpine1 24617 overexpression can inhibit aneurysm PMID: 9697825 Secreted. rat Aneurysm of heart Nkx2-5 114109 KO can induce aneurysm PMID: 11073884 septal aneurysm Nucleus. rat Aortic aneurysm Lox 24914 KO can induce aneurysm PMID: 12417550 "Secreted. Secreted, extracellular space." rat Aortic aneurysm Mmp14 81707 aortic: increase in protein level| increase in RNA level PMID: 15300177 Membrane ; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.. rat Aortic Dissection Col3a1 84032 haploinsufficiency can induce aneurysm repture PMID: 21071432 "Secreted, extracellular space, extracellular matrix." rat Aortic Dissection Klf15 85497 overexpression can inhibit the rupture of aneurysm| decrease in protein level| decrease in RNA level PMID: 26600407 rat Aortic Dissection Ptgfr 25652 the antagonist can induce aneurysm PMID: 25341845 Cell membrane; Multi-pass membrane protein. rat Cerebral aneurysm Ager 81722 ICA: increase in protein level PMID: 23844137 internal carotid artery (ICA) Membrane ; Single-pass type I membrane protein. rat Cerebral aneurysm Aoc3 29473 cerebral arterial wal: decrease in protein level PMID: 18312104 Membrane ; Single-pass type II membrane protein. rat Cerebral aneurysm Ccl2 24770 KO can inhibit aneurysm| increase in protein level| increase in RNA level PMID: 19164781 Secreted. rat Cerebral aneurysm Cst3 25307 aneurysmal wall: decrease in protein level| decrease in RNA level PMID: 18635848 Secreted. rat Cerebral aneurysm Ctsb 64529 aneurysmal wall: increase in protein level| increase in RNA level PMID: 18635848 "Lysosome. Melanosome. Secreted, extracellular space." rat Cerebral aneurysm Ctsk 29175 aneurysmal wall: increase in protein level| increase in RNA level PMID: 18635848 Lysosome. rat Cerebral aneurysm Lox 24914 CA wall: decrease in protein level| decrease in RNA level|RASMCs: the inhibitor can inhibit aneurysm PMID: 19359664 rat aortic vascular smooth muscle cells (RASMC) "Secreted. Secreted, extracellular space." rat Cerebral aneurysm Mmp14 81707 cerebral aneurysm tissue: increase in protein level PMID: 9724118 Membrane ; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.. rat Cerebral aneurysm Mmp2 81686 cerebral aneurysm: increase in RNA level| aneurysmal wall: increase in protein level| increase in RNA level| cerebral aneurysm tissue: increase in protein level PMID: 17569872| PMID: 17122420| PMID: 9724118 "Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).." rat Cerebral aneurysm Mmp9 81687 ICA: increase in protein level| cerebral aneurysm: increase in RNA level| aneurysmal wall: increase in protein level| increase in RNA level PMID: 23844137| PMID: 17569872| PMID: 17122420 internal carotid artery (ICA) "Secreted, extracellular space, extracellular matrix." rat Cerebral aneurysm Nos1 24598 aortic: increase in RNA level PMID: 16428894 "Cell membrane, sarcolemma ; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines.." rat Cerebral aneurysm Nos2 24599 the inhibitor can inhibit aneurysm| aortic: increase in RNA level PMID: 14615616| PMID: 16428894 rat Cerebral aneurysm Pkd1 24650 amino acid 2163 & 2773 PMID: 12842373 rat Cerebral aneurysm Pkd2 498328 amino acid 1811 & 1671 & 1587 PMID: 12842373 rat Cerebral aneurysm Plg 85253 cerebral aneurysm tissue: increase in protein level PMID: 9724118 Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity).. rat Cerebral aneurysm Ptgfr 25652 the antagonist can induce aneurysm PMID: 25341845 Cell membrane; Multi-pass membrane protein. rat Cerebral aneurysm Timp1 116510 KO can induce aneurysm| increase in RNA level PMID: 17569872 Secreted. rat Cerebral aneurysm Timp2 29543 KO can induce aneurysm| increase in RNA level| cerebral aneurysm: increase in RNA level PMID: 17569872 Secreted. rat Cerebral aneurysm Tlr4 29260 ICA: increase in protein level| cerebral aneurysm wall: increase in protein level PMID: 23844137| PMID: 19852543 internal carotid artery (ICA) "Cell membrane ; Single-pass type I membrane protein. Early endosome. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis. Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation.." rat Kawasaki disease Mmp9 81687 coronary artery: increase in protein level| increase in RNA level PMID: 18311803 "Secreted, extracellular space, extracellular matrix." rat Marfan syndrome Mmp12 117033 aneurysm: increase in protein level PMID: 16820601 "Secreted, extracellular space, extracellular matrix." rat Marfan syndrome Mmp14 81707 aneurysm: increase in protein level PMID: 16820601 Membrane ; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Forms a complex with BST2 and localizes to the cytoplasm.. rat Marfan syndrome Mmp2 81686 aneurysm: decrease in protein level PMID: 16820601 "Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).." rat Marfan syndrome Tgfbr2 81810 aneurysm: increase in protein level PMID: 16820601 Cell membrane ; Single-pass type I membrane protein. Membrane raft. rat Marfan syndrome Timp2 29543 aneurysm: increase in protein level PMID: 16820601 Secreted. rat Marfan syndrome Timp3 25358 aneurysm: decrease in protein level PMID: 16820601 "Secreted, extracellular space, extracellular matrix." rat Thoracic aortic aneurysm Adam10 29650 aortic: increase in protein level| increase in RNA level PMID: 20621845 Cell membrane ; Single-pass type I membrane protein. Golgi apparatus membrane ; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.. rat Thoracic aortic aneurysm Adam17 57027 aortic: increase in protein level| increase in RNA level PMID: 20621845 Membrane; Single-pass type I membrane protein. rat Thoracic aortic aneurysm Mmp1 300339 smooth muscle cells in aneurysm: increase in protein level PMID: 11567232 "Secreted, extracellular space, extracellular matrix." rat Thoracic aortic aneurysm Mmp2 81686 aortic: increase in protein level| increase in RNA level| thoracic aorta: increase in protein level| aneurysmal thoracic aorta: increase in protein level| smooth muscle cells in aneurysm: increase in protein level PMID: 20621845| PMID: 18178469| PMID: 17641224| PMID: 11567232 "Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).." rat Thoracic aortic aneurysm Mmp9 81687 aortic: increase in protein level| increase in RNA level| thoracic aorta: increase in protein level| aneurysmal thoracic aorta: increase in protein level| smooth muscle cells in aneurysm: increase in protein level PMID: 20621845| PMID: 18178469| PMID: 17641224| PMID: 11567232 "Secreted, extracellular space, extracellular matrix." rat Thoracic aortic aneurysm Spp1 25353 smooth muscle cells in aneurysm: increase in RNA level PMID: 11567232 Secreted. rat Thoracic aortic aneurysm and dissection Mmp1 300339 aortic: increase in RNA level PMID: 15561045 "Secreted, extracellular space, extracellular matrix." rat Thoracic aortic aneurysm and dissection Mmp2 81686 aortic: increase in RNA level PMID: 15561045 "Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).." rat Thoracic aortic aneurysm and dissection Mmp9 81687 aortic: increase in RNA level PMID: 15561045 "Secreted, extracellular space, extracellular matrix." rat Thoracic aortic aneurysm and dissection Timp2 29543 aortic: increase in RNA level PMID: 15561045 Secreted. rat Thoracic aortic dissection Fhl1 25177 KO inhibit the proliferation of SMC PMID: 21126853 Cytoplasm. rat