code	PMID	miRNA	disease	description
other	36948853	hsa-mir-40	Liver Cirrhosis	MiR-340 mediates the involvement of high mobility group box 1 in the pathogenesis of liver fibrosis
target gene	36948479	hsa-mir-29b	Zika Virus Infection	Zika virus NS1 suppresses VE-cadherin via hsa-miR-29b-3p/DNMT3b/MMP-9 pathway in human brain microvascular endothelial cells.
exosome	36948039	hsa-mir-130b	Wound Healing	ADSCs-derived exosomal H19 accelerates cutaneous wound healing via the miR-130b-3p/PPARγ/STAT3 axis
target gene	36947996	hsa-mir-221	Stomach Neoplasms	Downregulation of miR-221-3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1.
other	36947456	hsa-mir-497	Pancreatic Neoplasms	Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1.
target gene	36947452	hsa-mir-511	Carcinoma, Non-Small-Cell Lung	Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer.
genetics_knock down_suppress	36946780	hsa-mir-449b	Liver Neoplasms	LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis.
target gene	36946346	hsa-mir-155	Neuroblastoma	miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1
target gene	36946310	hsa-mir-6315	Spinal Cord Injuries	miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway.
target gene	36946075	hsa-mir-145	Uterine Cervical Neoplasms	miR-145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC.
circulation_biomarker_diagnosis_ns	36945942	hsa-mir-21	Hypertension, Pulmonary	Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension
circulation_biomarker_diagnosis_ns	36945942	hsa-mir-143	Hypertension, Pulmonary	Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension
target gene	36944545	hsa-mir-515	Stomach Neoplasms	Hsa_circ_0000670 promoted the progression of gastric cancer through the miR-515-5p/SIX1 molecular axis
target gene	36944544	hsa-mir-200b	Retinoblastoma	The effect of lncRNA ADPGK-AS1 on the proliferation and apoptosis of retinoblastoma cells by targeting miR-200b-5p
other	36944116	hsa-mir-425	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-195	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-429	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-218	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-181a	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-9	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-8485	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-215	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-484	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-619	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-214	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-16-2	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200b	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-141	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200c	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-130a	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200a	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
target gene	36943627	hsa-mir-454	Breast Neoplasms	LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
target gene	36943602	hsa-mir-96	Liver Cirrhosis	Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway.
target gene	36943433	hsa-mir-486	Psoriasis	Downregulation of circ_0024028 inhibits IL-22-induced keratinocyte proliferation and migration by miR-486-3p/AKT3 axis
other	36941992	hsa-mir-27b	Neuroblastoma	CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
exosome	36941991	hsa-mir-93	Osteoarthritis	Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9.
target gene	36941464	hsa-mir-145	Breast Neoplasms	LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-19b	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-16	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-92a	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-15b	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-451a	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-142	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-223	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
other	36941055	hsa-mir-34a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-146a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-101a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-15a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-42	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-125b	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
target gene	36940068	hsa-mir-188	Atherosclerosis	Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis
other	36939902	hsa-mir-210	Triple Negative Breast Neoplasms	High HIF- 1a, miR-210 and beclin-1 as well as negative Bcl-2 were inversely related to pathologic complete response following NACT.
other	36939397	hsa-mir-146a	Urinary Bladder Neoplasms	Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
exosome	36939367	hsa-mir-29a	Colorectal Neoplasms	Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier.
target gene	36939239	hsa-mir-140	Ovarian Neoplasms	lncRNA AC005224.4/miR-140-3p/SNAI2 regulating axis facilitates the invasion and metastasis of ovarian cancer through epithelial-mesenchymal transition
exosome	36939028	hsa-mir-29b	Stomach Neoplasms	Intraperitoneal transfer of miR-29b-containing small extracellular vesicles can suppress peritoneal metastases of gastric cancer.
target gene	36938678	hsa-mir-20a	Breast Neoplasms	LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.
target gene	36938448	hsa-mir-1281	Depression	MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1.
target gene	36937888	hsa-mir-490	renal fibrosis	Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p/HMGA2 axis
target gene	36937804	hsa-mir-23a	Pulmonary Disease, Chronic Obstructive	miR-23a-5p and miR-194-3pare important biomarkers for COPD patients with OP (osteoporosis) and may represent novel targets for diagnosis and treatment of COPD patients with OP.
circulation_biomarker_diagnosis_up	36937162	hsa-mir-205	Alopecia Areata	The serum expression of lncRNA HOTAIR was significantly downregulated in AA patients with a p value < 0.001, while the serum expression of both miRNA-205 and TGF-b1 were significantly upregulated in patients.
other	36936522	hsa-mir-29b	Diabetic Cardiomyopathies	Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP
other	36935520	hsa-mir-421	Osteoarthritis	Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
other	36935173	hsa-mir-9	cervical squamous cell carcinoma	Effects of miR-9-5p on the migration, invasion and epithelial-mesenchymal transition process in cervical squamous cell carcinoma.
target gene	36934373	hsa-mir-28	Lung Neoplasms	Haplotype-GGGT in long non-coding RNA MALAT1 inhibits brain metastatic lung cancer and lymph nodes of lung cancer via the MALAT1/miR-328/KATNB1
exosome	36934264	hsa-mir-107	Carcinoma, Non-Small-Cell Lung	Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5.
target gene	36934152	hsa-mir-85	Liver Cirrhosis	MIAT enhances the activation of HSCs, at least in part, via miR-3085-5p/YAP/EMT signaling pathway.
exosome	36934129	hsa-mir-663a	Diabetic Nephropathies	Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria.
other	36933242	hsa-mir-62	Myocardial Infarction	MicroRNA-362-3p Implicated in Cardioprotection Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing TP53INP2 and Regulating SDF-1/CXCR4 Pathway.
therapeutic target	36933170	hsa-mir-139	Thyroid Neoplasms	miR-139-5p involvement in iodine uptake metabolism and suggests its possible role as a therapeutic target in restoring iodine uptake in RAI-refractory DTC.
target gene	36932454	hsa-mir-15b	Glioblastoma	circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling.
genetics_GWAS	36932446	hsa-mir-26a	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
genetics_GWAS	36932446	hsa-mir-487b	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
genetics_GWAS	36932446	hsa-mir-1	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
other	36932387	hsa-mir-127	Carcinoma, Hepatocellular	The circCCAR1/miR-127-5p/WTAP feedback loop enhances the growth and metastasis of HCC.
target gene	36931409	hsa-mir-202	Atherosclerosis	MicroRNA-202-5p-dependent inhibition of Bcl-2 contributes to macrophage apoptosis and atherosclerotic plaque formation.
circulation_biomarker_diagnosis_ns	36931262	hsa-mir-142	Polycystic Ovary Syndrome	circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers
circulation_biomarker_diagnosis_ns	36931262	hsa-mir-598	Polycystic Ovary Syndrome	circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers
genetics_GWAS	36931173	hsa-mir-1	Aortic Aneurysm, Abdominal	The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis.
exosome	36930410	hsa-mir-200b	Carcinoma, Hepatocellular	Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma.
other	36930090	hsa-mir-17	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
other	36930090	hsa-mir-2355	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
other	36930090	hsa-mir-106a	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
exosome	36929868	hsa-mir-455	Nasopharyngeal Carcinoma	Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.
circulation_biomarker_diagnosis_ns	36929799	hsa-mir-146a	Diabetes, Gestational	A preliminary integrated analysis of miRNA-mRNA expression profiles reveals a role of miR-146a-3p/TRAF6 in plasma from gestational diabetes mellitus patients
target gene	36929708	hsa-mir-513b	Prostatic Neoplasms	Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.
other	36929702	hsa-mir-142	Nasopharyngeal Carcinoma	MicroRNA-142-5p promotes the proliferation and metastasis of nasopharyngeal carcinoma.
target gene	36929422	hsa-mir-34a	Colorectal Neoplasms	NONHSAG028908.3 sponges miR-34a-5p to promote growth of colorectal cancer via targeting ALDOA.
other	36928742	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway.
target gene	36927769	hsa-mir-409	Carcinoma, Hepatocellular	BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway.
exosome	36927608	hsa-mir-139	Myocardial Infarction	Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway.
genetics_GWAS	36926729	hsa-mir-34a	Ischemic Stroke	Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
other	36926723	hsa-mir-181b	Ischemic Stroke	miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.
target gene	36925075	hsa-mir-27a	Bronchiolitis Obliterans Syndrome	miR-27a-3p alleviates lung transplantation-induced bronchiolitis obliterans syndrome (BOS) via suppressing Smad-mediated myofibroblast differentiation and TLR4-induced dendritic cells maturation.
target gene	36924565	hsa-mir-223	Rhinitis, Allergic	MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7.
target gene	36923408	hsa-mir-155	Sepsis	CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression.
other	36923098	hsa-mir-29b	Squamous Cell Carcinoma of Head and Neck	The lncRNA XIST/miR-29b-3p/COL3A1 axis regulates central carbon metabolism in head and neck squamous cell carcinoma and is associated with poor tumor prognosis.
circulation_biomarker_diagnosis_ns	36923095	hsa-mir-4488	Non-alcoholic Fatty Liver Disease	Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease.
other	36922872	hsa-mir-484	Carcinoma, Hepatocellular	circFOXK2 upregulated the expression of protein FOXK2-142aa to promote LDHA phosphorylation and led to mitochondrial fission by regulating the miR-484/Fis1 pathway, ultimately activating the Warburg effect in HCC.
target gene	36922713	hsa-mir-1236	Ovarian Neoplasms	VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways.
target gene	36920708	hsa-mir-873	Colorectal Neoplasms	Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.
target gene	36920626	hsa-mir-490	Neuroblastoma	Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
target gene	36920269	hsa-mir-127	Breast Neoplasms	Decreased miR-127 promotes the occurrence of breast cancer via increasing the expression of SPP1.
other	36920046	hsa-mir-637	Carcinoma, Hepatocellular	Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.
target gene	36920044	hsa-mir-193a	Colorectal Neoplasms	Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
target gene	36919939	hsa-mir-29a	Cerebral Hemorrhage	Mechanism of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage via the miR-29a-3p/ACSL4 axis.
target gene	36919011	hsa-mir-182	Cicatrix, Hypertrophic	MicroRNA-182-5p Inhibits Hypertrophic Scar Formation by Inhibiting the Proliferation and Migration of Fibroblasts via SMAD4 Pathway.
other	36918702	hsa-mir-145	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
other	36918702	hsa-mir-125b	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
other	36918702	hsa-mir-29a	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
target gene	36918335	hsa-mir-1224	Keloid	Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p.
target gene	36917423	hsa-mir-204	Endometriosis	Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis.
target gene	36917402	hsa-mir-139	Hepatoblastoma	miR-139-3p/Wnt5A Axis Inhibits Metastasis in Hepatoblastoma.
target gene	36917325	hsa-mir-24-1	Carcinoma, Renal Cell	MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2.
target gene	36916542	hsa-mir-196a	Thyroid Neoplasms	MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells.
target gene	36916303	hsa-mir-592	Ovarian Neoplasms	MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
target gene	36916297	hsa-mir-150	Colonic Neoplasms	Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis.
other	36916095	hsa-mir-155	COVID-19	MicroRNA-155 is a main part of proinflammatory puzzle during severe coronavirus disease 2019 (COVID-19).
other	36916086	hsa-mir-17	Pneumonia	Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis.
other	36916084	hsa-mir-23a	Sepsis	ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
exosome	36915886	hsa-mir-93	Urinary Bladder Neoplasms	Exosomal miR-93-5p as an important driver of bladder cancer progression.
target gene	36915750	hsa-mir-101	Gastrointestinal Stromal Tumors	Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1.
other	36915463	hsa-mir-218	Colorectal Neoplasms	Up-regulation of PUM1 by miR-218-5p promotes colorectal tumor-initiating cell properties and tumorigenesis by regulating the PI3K/AKT axis.
other	36915149	hsa-mir-296	Hypertension, Pulmonary	Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling.
target gene	36915137	hsa-mir-34a	Osteoarthritis	Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.
other	36915125	hsa-mir-200c	Prostatic Neoplasms	CLIC6 and SCNN1A linked to miR-200c-3p had good prognostic potential and provided valuable insights into the pathogenesis of PCa.
target gene	36915121	hsa-mir-148b	Irritable Bowel Syndrome	apigenin dose-dependently abolished the inhibitory effect of IBS-exo on CACO-2 cell autophagy by regulating miR-148b-3p/ATG14 signaling.
target gene	36915057	hsa-mir-124	Endometriosis	PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
target gene	36914604	hsa-mir-31	acute myocardial infarction	LncRNA AC005332.7 Inhibited Ferroptosis to Alleviate Acute Myocardial Infarction Through Regulating miR-331-3p/CCND2 Axis.
exosome	36913799	hsa-mir-125b	Acute Lung Injury	miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury.
target gene	36913151	hsa-mir-619	Pre-Eclampsia	circPTK2 promotes proliferation, migration and invasion of trophoblast cells through the miR-619/WNT7B pathway in preeclampsia.
target gene	36913084	hsa-mir-429	Uterine Cervical Neoplasms	Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway.
target gene	36913076	hsa-mir-128	Prostatic Neoplasms	Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.
exosome	36912495	hsa-mir-196a	Lung Neoplasms	Exosomal miR-196a-5p enhances radioresistance in lung cancer cells by downregulating NFKBIA.
other	36912261	hsa-mir-74a	Pancreatitis	miR-374a-5p was downregulated in samples from AP patients
other	36912070	hsa-mir-61	Carcinoma, Non-Small-Cell Lung	NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
other	36911684	hsa-mir-17	Adenocarcinoma of Lung	LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma.
other	36911413	hsa-mir-203a	Triple Negative Breast Neoplasms	can predict the survival time of TNBC patients
other	36911413	hsa-mir-148b	Triple Negative Breast Neoplasms	can predict the survival time of TNBC patients
target gene	36911384	hsa-mir-129-2	Endometrial Neoplasms	lncRNA XIST/miR-129-2-3p axis targets CCP110 to regulate the proliferation, invasion and migration of endometrial cancer cells.
target gene	36911069	hsa-mir-129	Carcinoma, Non-Small-Cell Lung	5-FU-miR-129 inhibited NSCLC tumor growth and extended survival in vivo without toxic side effects.
other	36910369	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	Decreased expression of hsa-miR-16-1 is remarkable.
other	36910147	hsa-mir-16	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
other	36910147	hsa-mir-29b	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
other	36910147	hsa-mir-210	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-885	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-200c	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-1909	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-let-7d	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
other	36909201	hsa-mir-100	Respiratory Distress Syndrome	miR-100 could serve as novel potential therapeutic molecule in the amelioration of ARDS
target gene	36908850	hsa-mir-19	Uterine Cervical Neoplasms	miR-19-3p Targets PTEN to Regulate Cervical Cancer Cell Proliferation, Invasion, and Autophagy.
target gene	36908326	hsa-mir-627	Colorectal Neoplasms	microRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2.
target gene	36908025	hsa-mir-196b	Ovarian Neoplasms	Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.
target gene	36907052	hsa-mir-34a	Triple Negative Breast Neoplasms	MALAT-1 mediates innate and adaptive immune suppression events partially via targeting miR-34a/MICA/B and miR-175p/PD-L1/B7-H4 axes in TNBC patients and cell lines
other	36906874	hsa-mir-137	Prostatic Neoplasms	lncRNA-PCMF1/hsa-miR-137/Twist1 Axis Involved in the EMT Regulation of Prostate Cancer Cells
other	36906716	hsa-mir-195	uterine corpus endometrial carcinoma	miR-195-5P negatively regulated the expression of PSAT1 in UCEC.
target gene	36905560	hsa-mir-79	Glioblastoma	Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma.
target gene	36905464	hsa-mir-20b	Breast Neoplasms	Silibinin had a strong anti-tumorigenic activity through BCL2L11upregulation and MiR-20b down expression
target gene	36905318	hsa-mir-182	Breast Neoplasms	Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription.
other	36905274	hsa-mir-34a	colorectal adenocarcinoma	The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa
other	36905274	hsa-mir-4b	colorectal adenocarcinoma	The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa
other	36902848	hsa-mir-196b	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-195	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-648	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-767	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-181c	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-181d	Glioblastoma	Possible Effect on Temozolomide Sensitivity
target gene	36902482	hsa-mir-29b	Triple Negative Breast Neoplasms	By inhibiting the expression level of miR-29b-3p, it was shown that complex regulatory pathways targeted this transcript in TNBC cells.
other	36902184	hsa-mir-199a	Squamous Cell Carcinoma of Head and Neck	MiR-199a-5p-Regulated SMARCA4 Promotes Oral Squamous Cell Carcinoma Tumorigenesis.
exosome	36902024	hsa-mir-21	Carcinoma, Hepatocellular	Hepatocellular Carcinoma Cell-Derived Exosomal miR-21-5p Induces Macrophage M2 Polarization by Targeting RhoB.
other	36901866	hsa-mir-93	Endometriosis	The expression of miR-30a (p = 0.0018) and miR-93 (p = 0.0052) was significantly upregulated in the eutopic endometrium of women with endometriosis compared to the controls.
other	36901866	hsa-mir-143	Endometriosis	MiR-143 (p = 0.0225) expression also showed a statistical difference between the eutopic endometrium of women with endometriosis and the control group.
other	36901860	hsa-mir-149	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901860	hsa-mir-23b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MIR323B (rs56103835) were associated with protection from gastrointestinal toxicity
other	36901860	hsa-mir-200c	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment.
other	36901860	hsa-mir-499a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment.
other	36901860	hsa-mir-2053	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901860	hsa-mir-938	Precursor Cell Lymphoblastic Leukemia-Lymphoma	rs2505901 (MIR938) was associated with protection from this toxicity
other	36901860	hsa-mir-605	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901760	hsa-mir-483	Pterygium	RT-qPCR gene expression analysis confirmed IGF2 upregulation and demonstrated miR-483 expression in pterygium compared to normal conjunctiva (253.2-fold and 12.47-fold, respectively)
other	36901745	hsa-mir-203a	Osteoarthritis	miR203a-3p displayed a protective role reducing the inflammatory effects
genetics_overexpression_suppress	36901700	hsa-mir-101	Carcinoma, Hepatocellular	HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC.
genetics_overexpression_suppress	36901700	hsa-mir-490	Carcinoma, Hepatocellular	HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC.
circulation_biomarker_diagnosis_ns	36899831	hsa-mir-146a	Alzheimer Disease	Alzheimer's Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells.
target gene	36899278	hsa-mir-122	Dyslipidemias	miR-122 dysregulation is associated with type 2 diabetes mellitus-induced dyslipidemia and hyperglycemia independently of its rs17669 variant.
target gene	36899270	hsa-mir-510	Nasopharyngeal Carcinoma	Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis.
target gene	36899199	hsa-mir-139	Esophageal Neoplasms	MiR-139 Affects Radioresistance in Esophageal Cancer by Targeting the PDK1/AKT/Cyclin D1 Signaling Pathway.
exosome	36898846	hsa-mir-885	Stomach Neoplasms	Fusobacterium nucleatum induced exosomal HOTTIP promotes gastric cancer progression through miR-885-3p/EphB2 axis.
target gene	36897170	hsa-mir-424	Osteosarcoma	A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis.
circulation_biomarker_diagnosis_up	36896567	hsa-mir-200c	Carcinoma, Ovarian Epithelial	circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
circulation_biomarker_diagnosis_up	36896567	hsa-mir-200b	Carcinoma, Ovarian Epithelial	circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
exosome	36895784	hsa-mir-24	Inflammatory Bowel Diseases	TNF-a Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p.
target gene	36895489	hsa-mir-181a	Colorectal Neoplasms	The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation.
target gene	36894989	hsa-mir-760	Osteoarthritis	MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis.
target gene	36893940	hsa-mir-17	Adenocarcinoma of Lung	CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma.
other	36893709	hsa-mir-133a	Triple Negative Breast Neoplasms	MiR-133a/CD47 axis is a novel prognostic biomarker to promote triple negative breast cancer progression.
other	36892621	hsa-mir-125a	Medulloblastoma	Lower levels of microRNA-125a showed a tendency toward poor survival rates;
target gene	36892495	hsa-mir-152	Ovarian Neoplasms	Evodiamine inhibits malignant progression of ovarian cancer cells by regulating lncRNA-NEAT1/miR-152-3p/CDK19 axis.
target gene	36892025	hsa-mir-515	Stomach Neoplasms	circ_0006089 facilitates gastric cancer progression via decoying miR-515-5p and up-regulating CXCL6.
therapeutic target	36891498	hsa-mir-29b	Muscular Atrophy	small-molecule inhibitor of miR-29b that could act as a potential therapeutic agent for muscle atrophy
other	36890588	hsa-mir-494	Intervertebral Disc Degeneration	miR-494/SIRT3/mitophagy signaling pathway is responsible for the apoptosis and mitochondrial dysfunction of NP cells and that DHJSD may exert protective effects against IVD degeneration by regulating the miR-494/SIRT3/mitophagy signal axis.
target gene	36890438	hsa-mir-218	Atherosclerosis	MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis.
genetics_knock down_promote	36890211	hsa-mir-200b	Colorectal Neoplasms	Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
other	36889776	hsa-mir-195	Uterine Cervical Neoplasms	LncRNA CERS6-AS1 Is a Tumor Promoter in Cervical Cancer by Sponging miR-195-5p.
other	36889771	hsa-mir-525	Carcinoma, Non-Small-Cell Lung	LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP.
target gene	36889769	hsa-mir-26a	Breast Neoplasms	MiR-26a-5p Heightens Breast Cancer Cell Sensitivity to Paclitaxel via Targeting Flap Endonuclease 1.
target gene	36889766	hsa-mir-490	Adenocarcinoma of Lung	MiR-490-3p Sponged by lncRNA NEAT1 Can Attenuate Lung Adenocarcinoma Progression by Suppressing the RhoA/ROCK Signaling Pathway.
target gene	36889764	hsa-mir-118	Colorectal Neoplasms	Long Non-Coding RNA HAND2 Antisense RNA 1 Inhibits Colorectal Cancer Development by Sponging microRNA-3118/Leptin Receptor Axis.
genetics_knock down_suppress	36889763	hsa-mir-70	Uterine Cervical Neoplasms	CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway.
target gene	36889762	hsa-mir-218	Carcinoma, Non-Small-Cell Lung	Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
target gene	36889558	hsa-mir-154	Adenocarcinoma of Lung	LINC00115 regulates lung adenocarcinoma progression via sponging miR-154-3p to modulate Sp3 expression.
target gene	36889174	hsa-mir-152	Colorectal Neoplasms	miR-152-3p facilitates cell adhesion and hepatic metastases in colorectal cancer via targeting AQP11.
therapeutic target	36888755	hsa-mir-766	Sepsis	circPTK2/miR-766/eIF5A axis ameliorates septic ALI, developing a novel therapeutic target for the disease
target gene	36884182	hsa-mir-124	Prostatic Neoplasms	MiR-124-3p inhibits tumor progression in prostate cancer by targeting EZH2.
target gene	36884165	hsa-mir-136	Esophageal Squamous Cell Carcinoma	Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.
other	36883849	hsa-mir-155	Neuroinflammatory Diseases	MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation.
target gene	36882858	hsa-mir-34a	Ototoxicity	miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress.
other	36882799	hsa-mir-146b	Carcinoma, Renal Cell	MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma.
other	36882663	hsa-mir-16	pancreatic adenocarcinoma	The lncRNA PVT1/hsa-miR-16-5p/CASP6/CASP8 regulatory axis plays an vital role in regulating the anti-tumor immune responses for PAAD.
other	36882006	hsa-mir-34a	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36882006	hsa-mir-181a	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36882006	hsa-mir-28	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36881359	hsa-mir-136	Carcinoma, Hepatocellular	Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis.
target gene	36881345	hsa-mir-29b	Osteoporosis	microRNA-29b-3p/sirtuin-1/peroxisome proliferator-activated receptor γ suppress osteogenic differentiation.
target gene	36881338	hsa-mir-1	Colorectal Neoplasms	CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.
target gene	36880587	hsa-mir-24	Osteosarcoma	MicroRNA-324-3p inhibits osteosarcoma progression by suppressing PGAM1-mediated aerobic glycolysis.
target gene	36880288	hsa-mir-128	Alzheimer Disease	MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease.
target gene	36880039	hsa-mir-147b	Stomach Neoplasms	MIR-147B Regulated Proliferation and Apoptosis of Gastric Cancer Cells by Targeting CPEB2 Via the PTEN Pathway.
circulation_biomarker_diagnosis_ns	36879801	hsa-mir-17	Fabry Disease	Exercise-intolerance, blood-lactate increase, and the underlying miR-17/HIF-1 pathway may become useful therapeutic targets and diagnostic/monitoring tools in FD.
other	36879212	hsa-mir-6756	pancreatic ductal adenocarcinoma	LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis.
other	36879212	hsa-mir-4694	pancreatic ductal adenocarcinoma	LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis.
target gene	36879069	hsa-mir-30	Atherosclerosis	miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.
target gene	36878000	hsa-mir-74b	Multiple Sclerosis	MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis
other	36877445	hsa-mir-203a	obsolete Helicobacter pylori infectious disease	H. pylori could contribute to the process of carcinogenesis by downregulating miR-203a
target gene	36876834	hsa-mir-29c	esophageal carcinoma	E2F1 Reduces Sorafenib's Sensitivity of Esophageal Carcinoma Cells via Modulating the miR-29c-3p/COL11A1 Signaling Axis.
target gene	36876724	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in non-small cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144.
target gene	36876422	hsa-mir-211	Stomach Neoplasms	LncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
target gene	36874625	hsa-mir-26b	Colorectal Neoplasms	lncRNA HCG11 Promotes Colorectal Cancer Cell Malignant Behaviors via Sponging miR-26b-5p.
circulation_biomarker_diagnosis_ns	36874371	hsa-mir-92a	Ischemic Stroke	Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
circulation_biomarker_diagnosis_ns	36874371	hsa-mir-75	Ischemic Stroke	Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
target gene	36874361	hsa-mir-610	Melanoma	LINC00511 promotes melanoma progression by targeting miR-610/NUCB2.
other	36873400	hsa-mir-21	Atrial Fibrillation	miR-21-5p as a biomarker that reflects the extent of left atrial fibrosis in AF patients.
target gene	36873253	hsa-mir-221	Carcinoma, Non-Small-Cell Lung	TP63 Functions as a Tumor Suppressor Regulated by GAS5/miR-221-3p Signaling Axis in Human Non-Small Cell Lung Cancer Cells.
target gene	36873181	hsa-mir-23b	Pulmonary Fibrosis	A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis.
genetics_knock down_promote	36872771	hsa-mir-29a	Ischemic Stroke	CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
other	36872450	hsa-mir-26b	Eosinophilic Esophagitis	miR-26b-5p deregulated in saliva
other	36872450	hsa-mir-142	Eosinophilic Esophagitis	miR-142-5p deregulated in saliva
other	36872450	hsa-let-7i	Eosinophilic Esophagitis	Let-7i-5p deregulated in saliva
other	36872450	hsa-mir-205	Eosinophilic Esophagitis	miR-205-5p deregulated in saliva
other	36872450	hsa-mir-27b	Eosinophilic Esophagitis	miR-27b-3p deregulated in saliva
other	36871032	hsa-mir-424	Infertility, Male	upregulated miRNA, notably miR-424
target gene	36870548	hsa-mir-5009	Adenocarcinoma of Lung	LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis.
other	36869885	hsa-mir-71a	Testicular Neoplasms	microRNA-371a-3p showed significantly higher expression rates than other markers suggesting its superior clinical usefulness.
circulation_biomarker_diagnosis_ns	36869070	hsa-mir-21	Brain Injuries, Traumatic	Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients.
other	36869031	hsa-mir-136	Endometrial Neoplasms	PVT1/miR-136/Sox2/UPF1 axis regulates the malignant phenotypes of endometrial cancer stem cells.
circulation_biomarker_diagnosis_up	36868502	hsa-mir-1271	Endometriosis	blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group
circulation_biomarker_diagnosis_up	36868502	hsa-mir-490	Endometriosis	blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group
lncRNA target	36867300	hsa-mir-218	Glioma	CircRNA-104718 modulates glioma cell proliferation through the miR
other	36867268	hsa-mir-4428	Adenocarcinoma of Lung	In conclusion, circGRAMD1B is discovered to modulate miR-4428/SOX4/MEX3A axis to further activate PI3K/AKT pathway, finally boosting migration, invasion, and EMT of LUAD cells.
exosome	36866739	hsa-mir-143	Osteosarcoma	Briefly, transfer of exosomal miR1433p confers doxorubicin resistance in osteosarcoma cells.
circulation_biomarker_diagnosis_ns	36865390	hsa-mir-1246	Breast Neoplasms	The expression levels of circulation miR-1246, HOTAIR, and IL-39 could be considered early diagnostic biomarkers in BC patients.
other	36864416	hsa-mir-183	Stomach Neoplasms	"RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression."
other	36864416	hsa-mir-200	Stomach Neoplasms	"RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression."
circulation_biomarker_diagnosis_ns	36864077	hsa-mir-20a	COVID-19	In the present study, serum MiRNA-106a and miRNA-20a were quantified by real time-PCR in 50 COVID-19 patients hospitalized at Minia university hospital and 30 healthy volunteers.
transcription factor target	36863315	hsa-mir-34a	Inflammation	Thus, miR-34a and senescent PDL cells might be promising therapeutic targets for periodontitis in elderly people.
other	36863142	hsa-mir-146a	Osteoarthritis	induced rabbit OA model was established to investigate the therapeutic role of miR-146a-5p in OA.
lncRNA target	36862865	hsa-mir-126	Carcinoma, Ovarian Epithelial	Though in our previous study we found that miR-126 may inhibit proliferation and invasion in EOC cell lines, but in this study patients with elevated miR-126 expression exhibited poor overall survival and relapse free survival.
other	36862332	hsa-mir-1	Pancreatitis	In addition, the method was also utilized to detect the miRNA-31 expression in collected clinical samples from pancreatitis patients and demonstrated that miRNA-31 was upregulated in patients, showing a great promising of the method in clinical application.
circulation_biomarker_diagnosis_ns	36862282	hsa-mir-940	Bulimia Nervosa	The expression patterns of JHDM1D-AS1, miR-940 and ARTN in BC cells were altered by lentivirus infection and plasmid transfection for functional assays on the biological properties of BC cells.
other	36862282	hsa-mir-940	Breast Neoplasms	In this study, we clarified the mechanistic understanding of JHDM1D-AS1-miRARTN ceRNA network in the development of breast cancer (BC).
genetics_overexpression_promote	36862227	hsa-mir-320c	Cartilage Diseases	METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling.
genetics_overexpression_promote	36862227	hsa-mir-320c	Osteoarthritis	METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling.
genetics_overexpression_promote	36862005	hsa-mir-483	Colorectal Neoplasms	Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures (m-colospheres), here we show that the overexpression of microRNA 483-3p (miRNA
genetics_knock down_promote	36861928	hsa-mir-497	Adenocarcinoma of Lung	Also, LINC00511 and SMAD3 were overexpressed, while miR
target gene	36861798	hsa-mir-4660	Triple Negative Breast Neoplasms	(R)-9bMS inhibited the protein synthesis and autophagy of triple negative breast cancer cells via regulating miR-4660/mTOR axis.
transcription factor target	36861382	hsa-mir-192	Diabetic Retinopathy	5p attenuates DR progression by targeting ELAVL1 and reducing PI3Kdelta expression, suggesting a biomarker for the treatment of DR.
circulation_biomarker_diagnosis_ns	36861291	hsa-mir-143	Arthritis	3p and cell factor generation in peripheral blood (PB) of RA sufferers were identified by ELISA or RT-qPCR.
genetics_overexpression_promote	36861149	hsa-mir-1256	Thyroid Cancer, Papillary	Methods The expression of circ_0092315 in papillary thyroid carcinoma cells was examined by real-time fluorescence quantitative PCR.The proliferation and invasion of TPC-1 cells was assessed by CCK-8 and Transwell assays.The protein level of high mobility group A2 (HMGA2) was determined by Western blotting.The regulatory relationship of circ_0092315,microRNA-1256 (miR-1256),and HMGA2 was explored by bioinformatics tools,dual-luciferase reporter assay,real-time fluorescence quantitative PCR,and Western blotting. +++Results circ_0092315 was overexpressed in papillary thyroid carcinoma cells (all P<0.001).circ_0092315 promoted the proliferation and invasion of TPC-1 cells (all P<0.001).The transfection of si-circ_0092315 up-regulated the expression of miR-1256 (P<0.001),and miR-1256 inhibitor up-regulated the protein level of HMGA2 (P<0.001).
other	36860345	hsa-mir-21	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
other	36860345	hsa-mir-584	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
other	36860345	hsa-mir-200a	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
circulation_biomarker_prognosis_ns	36860299	hsa-mir-486	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-193b	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-410	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-369	Subarachnoid Hemorrhage	The circulating exosomes miR
other	36859458	hsa-mir-146a	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
other	36859458	hsa-mir-5001	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
other	36859458	hsa-mir-17	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
transcription factor target	36859185	hsa-mir-4739	Breast Neoplasms	Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth.
transcription factor target	36859185	hsa-mir-658	Breast Neoplasms	Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth.
circulation_biomarker_diagnosis_ns	36859176	hsa-mir-155	Obesity	The present study was designed to investigate expression patterns of miR-146a, miR-155, miR-15a, miR-193a, and miR-122 in peripheral blood mononuclear cells (PBMCs) in children who are obese along with their association with metabolic and inflammatory biomarkers.
circulation_biomarker_diagnosis_up	36858407	hsa-mir-155	Arthritis, Rheumatoid	RESULTS: Compared with the normal group, the pain threshold was significantly decreased (P<0.05), and the knee circumference was significantly increased (P<0.05); the synovial tissue of knee joints showed significant hyperplasia, abundant blood flow signal, joint cavity effusion and obvious inflammatory invasion, the pathological score was significantly increased (P<0.05), the expressions of miR-155 mRNA and IL-1beta, IL-17A, TLR4, NF-kappaB p65 proteins were significantly increased (P<0.05), the expressions of SOCS1 mRNA and protein were significantly decreased (P<0.05) in the model group.
lncRNA target	36858024	hsa-mir-124	Brain Injuries, Traumatic	Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI.
lncRNA target	36858024	hsa-mir-124	Parkinson Disease	Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI.
other	36857620	hsa-mir-370	Endometrial Neoplasms	3p /MAPK1 axis.
genetics_overexpression_promote	36857196	hsa-mir-132	Colorectal Neoplasms	3p or overexpressing IGF2BP1 reversed such effects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-27b	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-381	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-451a	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
lncRNA target	36856372	hsa-mir-30	Colorectal Neoplasms	5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments.
genetics_overexpression_suppress	36856212	hsa-mir-125b	Osteosarcoma	Modulation of miR-125b-5p and RAB3D levels produced opposite effects on proliferation and migration of osteosarcoma cells, and in cells with overexpression of both miR-125b-5p and RAB3D, the effect of RAB3D on cell proliferation and migration was blocked by miR-125b-5p overexpression (P < 0.05).
lncRNA target	36856205	hsa-mir-506	High Grade Ovarian Neoplasms	3p may affect EMT of ovarian cancer cells by regulating cell migration and invasion via SNAI2, and its expression level has predictive value for HGSOC recurrence.
transcription factor target	36856174	hsa-mir-12200	Osteoporosis, Postmenopausal	The inhibition of miR5p would almost fully alleviate postmenopausal osteoporosis.
lncRNA target	36856174	hsa-mir-12200	Osteoporosis	The inhibition of miR
transcription factor target	36856108	hsa-mir-503	Intervertebral Disc Degeneration	CONCLUSIONS: miR-503 can improve the function and activity of human nucleus pulposus cells of degenerated intervertebral disc by inhibiting Wnt expression.
lncRNA target	36856073	hsa-mir-210	Fetal Hypoxia	TET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia.
lncRNA target	36856073	hsa-mir-210	Uterine Diseases	Together, our study reveals a novel mechanistic link between the miRTET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia.
lncRNA target	36856073	hsa-mir-210	Mitochondrial Diseases	Hypoxia during pregnancy impairs uterine vascular adaptation via microRNA-210 (miR-210)-mediated mitochondrial dysfunction and mitochondrial reactive oxygen species (mtROS) generation.
transcription factor target	36855796	hsa-mir-590	Colonic Neoplasms	After repressing miR3p with G4-CSSD590, the upregulation of CLCA1, B3GNT6 and UGT2A3 inhibited the proliferation and metastasis of colon cancer cells.
other	36855431	hsa-mir-150	Carcinoma, Hepatocellular	CONCLUSION: ZFAS1 is associated with the malignant status and prognosis of patients with hepatocellular carcinoma, and the ZFAS1/miR5p axis is involved in hepatocellular carcinoma progression.
genetics_knock down_promote	36854894	hsa-mir-424	Cholangiocarcinoma	5p reversed the HCG18 knockdown induced suppression on cholangiocarcinoma cancer cells.
other	36854781	hsa-mir-194	Colorectal Neoplasms	Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development.
other	36854781	hsa-mir-378a	Colorectal Neoplasms	Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development.
other	36854749	hsa-mir-200b	Diabetes Mellitus	Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing.
other	36854749	hsa-mir-200b	Wounds and Injuries	Anti-miR-200b delivery to murine injury sites likewise enhanced tissue perfusion, wound closure, and vasculogenic fibroblast contribution to perfused vessels in a FLI1 dependent manner. Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing.
transcription factor target	36853410	hsa-mir-21	Breast Neoplasms	We demonstrate the assay with the detection of target miRNA-21 in total RNA extracted from MCF-7 cancer cells.
lncRNA target	36853001	hsa-mir-10b	Pancreatitis, Chronic	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-let-7a	Pancreatic Carcinoma	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-mir-10b	Pancreatic Carcinoma	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-let-7a	Pancreatitis, Chronic	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36852954	hsa-mir-1	Myotonic Disorders	Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM.
lncRNA target	36852954	hsa-mir-1	Dmd-Associated Dilated Cardiomyopathy	Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM.
target gene	36852950	hsa-mir-485	Adenocarcinoma of Lung	Circ_0070440 modulated LUAD malignant progression and ferroptosis via targeting SLC7A11, implying a significant role of the circ_0070440/miR-485-5p/SLC7A11 axis in the diagnosis and treatment of LUAD.
circulation_biomarker_diagnosis_up	36852944	hsa-mir-296	Coronary Disease	RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS.
circulation_biomarker_diagnosis_down	36852944	hsa-mir-296	Coronary Artery Disease	RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS.
other	36852928	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
other	36852928	hsa-mir-96	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
other	36852928	hsa-mir-183	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
transcription factor target	36852907	hsa-mir-221	Diabetic Cardiomyopathies	These data suggest that the protection of luteolin against DCM, at least, is related to suppressing JNK/c-Jun-regulated miR-221 and the subsequent blockage of autophagy.
genetics_overexpression_promote	36852794	hsa-mir-16	Glioblastoma	5p ablation and SEPT2 overexpression.
other	36852793	hsa-mir-155	Neuroblastoma	erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004)
other	36852793	hsa-mir-223	Neuroblastoma	erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004)
genetics_overexpression_promote	36852468	hsa-mir-613	Carcinoma, Renal Cell	Furthermore, a rescue assay with AXL overexpression was performed to make a profound study whether miR-613 disturbs RCC proliferation, invasion, and migration through direct regulation of AXL.
lncRNA target	36852402	hsa-mir-3	Angelman Syndrome	Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity.
lncRNA target	36852402	hsa-mir-3	Fluoride Poisoning	Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity.
lncRNA target	36852302	hsa-mir-939	Colonic Neoplasms	Moreover, Fusobacterium nucleatum promotes COAD progression through the miR3p/FUT1/MUC2 axis.
genetics_knock down_promote	36852074	hsa-mir-30	Stomach Neoplasms	A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p.
genetics_knock down_promote	36852074	hsa-mir-34a	Stomach Neoplasms	A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p.
transcription factor target	36852042	hsa-mir-16	Neurogenic Inflammation	It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16.
transcription factor target	36852042	hsa-mir-16	Inflammation	It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16.
therapeutic target	36851875	hsa-mir-541	Thyroid Cancer, Papillary	circNRIP1 can be a prognostic biomarker and therapeutic target for PTC by acting as a sponge for oncogenic miR-541-5p and miR-3064-5p to upregulate PKM2 expression.
circulation_biomarker_diagnosis_up	36851429	hsa-mir-126	Lymphoma	However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine.
other	36851429	hsa-mir-192	Lymphoma	Expression of miR-18b and miR-192 was higher in carcinomas of the small intestine than in those of the large intestine.
circulation_biomarker_diagnosis_up	36851429	hsa-mir-18b	Lymphoma	However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine.
therapeutic target	36848481	hsa-mir-372	Stomach Neoplasms	downregulation of miR-372-5p may be assumed as a possible therapeutic target in treating gastric cancer.
lncRNA target	36848349	hsa-mir-942	Esophageal Squamous Cell Carcinoma	5p/CST1 axis might be a promising target for diagnosis and treatment of ESCC.
other	36848313	hsa-mir-19a	Pulmonary Fibrosis	Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression.
other	36848313	hsa-mir-19a	Lung Neoplasms	Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression.
lncRNA target	36848245	hsa-mir-27a	Cholangiocarcinoma	FoxO signalling was predominantly downregulated by miR-27a-3p in CCA, partially through targeting of FOXO1.
lncRNA target	36848007	hsa-mir-203a	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-16	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-26b	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-335	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-125b	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
genetics_knock down_suppress	36847916	hsa-mir-422a	Osteoporosis	Finally, since adipocytes released a higher amount of miR-422a in culture medium compared to hBMSCs we analyzed the levels of circulating miR-422a in patients with osteoporosis-a condition characterized by increased marrow adiposity-demonstrating that its levels are negatively correlated with T- and Z-scores. Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis.
genetics_knock down_suppress	36847916	hsa-mir-422a	Bone Diseases, Metabolic	Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis.
lncRNA target	36847717	hsa-mir-204	Sciatic Neuropathy	In summary, HAGLR promoted SC proliferation, migration, neurotrophic factor production, and facilitated functional recovery of SNC rats via miR-204/CDK5R1.
other	36847693	hsa-mir-23b	Uterine Cervical Neoplasms	The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells.
genetics_overexpression_promote	36847222	hsa-mir-252	Wounds and Injuries	Notably, co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression, further supporting that Rab6 is a biologically relevant target of miR
other	36847199	hsa-mir-545	Aortic Aneurysm, Abdominal	3p/CKAP4 axis, adding further understanding of the pathogenesis of AAA and a potential therapeutic approach in AAA management.
other	36847071	hsa-mir-142	Colorectal Neoplasms	LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
target gene	36846943	hsa-mir-152	Lung Neoplasms	ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
transcription factor target	36846934	hsa-mir-133b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: miR-133b downregulates FOXL2 by targeting the 3'-UTR of FOXL2, thereby inhibiting cell proliferation, EMT and metastasis induced by the TGF-beta/Smad signaling pathway in NSCLC.
genetics_knock down_suppress	36846012	hsa-mir-188	Angelman Syndrome	RASSF8-AS1 knockdown caused an increase in miR
other	36845968	hsa-mir-455	Osteoarthritis	3p in OA was downregulated, while PTEN was upregulated (P < 0.05) in comparison to healthy chondrocytes (P < 0.05).
target gene	36845963	hsa-mir-222	Breast Neoplasms	MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3.
target gene	36845963	hsa-mir-221	Breast Neoplasms	MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3.
other	36845957	hsa-mir-582	Obesity	5p-Elovl5 network may be disrupted in lipid metabolism and lead to obesity in the offspring of obese dams.
other	36845651	hsa-mir-103a-2	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
other	36845651	hsa-mir-181d	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
other	36845651	hsa-mir-199a	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
genetics_overexpression_promote	36845338	hsa-mir-186m	Carcinoma, Non-Small-Cell Lung	In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs.
genetics_overexpression_promote	36845338	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs.
other	36845111	hsa-mir-30	Chilblain lupus	3p contributes to HBV immune escape, which may provide novel insights into the roles of interaction networks among lncRNA, miRNA, and mRNA in HBV immune escape, highlighting potential applications of lnc-AIFM2-1 and CD244 for diagnosis and treatment in CHB.
transcription factor target	36845016	hsa-mir-206	Hypertension, Renal	CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy.
transcription factor target	36845016	hsa-mir-205	Hypertension, Renal	CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy.
lncRNA target	36845011	hsa-mir-9a	Ischemic Stroke	PURPOSE: Present research is aimed at exploring the effect of miR-9a-5p on mitochondrial autophagy and alleviating cellular oxidative stress injury in ischemic stroke. CONCLUSION: miR-9a-5p protects against ischemic stroke by inhibiting OGD/R-induced mitochondrial autophagy and alleviating cellular oxidative stress injury.
exosome	36844871	hsa-mir-1	Stomach Neoplasms	Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients.
exosome	36844871	hsa-mir-375	Stomach Neoplasms	Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients.
target gene	36844868	hsa-mir-613	Carcinoma, Non-Small-Cell Lung	Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization.
exosome	36844629	hsa-mir-187	Breast Neoplasms	Taxol-resistant breast cancer cell-derived exosome-delivered miR-187-5p regulates the growth of breast cancer cells via ABCD2 and Wnt/beta-catenin signaling.
genetics_GWAS	36843628	hsa-mir-26a	Acute Coronary Syndrome	This study aimed to determine the association between genetic (CYP2C19 and P2Y12 polymorphisms) and epigenetic (DNA methylation of CYP2C19 and P2Y12 and miRNA-26a expression) factors and their effects on MACEs among post-PCI patients. This study demonstrated that hypomethylation of CYP2C19 and miRNA-26a upregulation increased the risk of clopidogrel resistance in post-PCI patients, but there was no correlation between clopidogrel resistance and MACEs.
transcription factor target	36843205	hsa-mir-216a	Arthritis, Rheumatoid	These results revealed that the miR-216a-3p/DUSP5 pathway may play a crucial role in the malignant behavior of FLS, which may serve as a new target for the treatment of RA.
other	36842554	hsa-mir-339	Schizophrenia	This study aimed to determine the Role of miRNA- 339-5p in the Regulation of Klotho Gene Expression and its Circulatory Levels in Schizophrenia.
lncRNA target	36841811	hsa-mir-130a	Myocardial Reperfusion Injury	Collectively, our findings suggest that miR-130a regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial IRI.
lncRNA target	36841801	hsa-mir-506	Colorectal Neoplasms	CONCLUSIONS: Our study showed that LINC00543 enhanced EMT of CRC cells through the pre-miR3p/FOXQ1 axis.
other	36841760	hsa-mir-15a	Stomach Neoplasms	Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p.
genetics_overexpression_promote	36841132	hsa-mir-519c	Melanoma	Finally, we showed restoration of miR-519c-3p in NEAT1-overexpressing SK-MEL-5 CDDP Res cells successfully overrode the NEAT1-promoted cisplatin resistance in melanoma from in vitro and in vivo results.
circRNA target	36840946	hsa-mir-421	Prostatic Neoplasms	The rescue assay results for the PC3 and Du145 cell lines demonstrated that circDHRS3 inhibits prostate cancer cell lines' ability to proliferate and metastasize by modulating MEIS2 expression through the circDHRS3/miR-421/MEIS2 axis. Our study indicates that circDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis.
genetics_overexpression_promote	36840697	hsa-mir-431	Colorectal Neoplasms	Additionally, miR-431 suppression or SLC7A11 overexpression overturned circSTIL silencing-mediated cell phenotypes in CRC cells. CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC.
genetics_overexpression_promote	36840487	hsa-mir-450b	Liver Failure, Acute	MDM2 overexpression reversed the repressive effects of elevated miR-450b-5p on ALF.
other	36840403	hsa-mir-146a	Dengue	These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters.
other	36840403	hsa-mir-96	Dengue	These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters.
circulation_biomarker_diagnosis_ns	36836704	hsa-mir-172	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
circulation_biomarker_diagnosis_ns	36836704	hsa-mir-1285	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
circulation_biomarker_diagnosis_up	36836704	hsa-mir-335	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
other	36836631	hsa-mir-194	Acquired Immunodeficiency Syndrome	The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease.
other	36836631	hsa-mir-122	Acquired Immunodeficiency Syndrome	The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease.
other	36835984	hsa-mir-146a	Osteoarthritis	TREM1, LIF, miR146-5a, and GAS5 were identified to be OA-related genes and potential regulatory pathways.
lncRNA target	36835852	hsa-mir-199a	Chondrocyte Hypertrophy	The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation.
lncRNA target	36835852	hsa-mir-199a	Osteoarthritis	The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation.
other	36835336	hsa-mir-155	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
other	36835336	hsa-mir-21	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
other	36835336	hsa-mir-10b	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
genetics_overexpression_promote	36835287	hsa-mir-193b	Hyperglycemia	Overexpression of hsa-miR-193b-3p under hyperglycemia also resulted in excess accumulation of intracellular lipid droplets in HepG2 cells.
circulation_biomarker_diagnosis_up	36835287	hsa-mir-193b	Metabolic-Associated Fatty Liver Disease	This study supports further research into potential use of microRNA hsa-miR-193b-3p as a possible clinically relevant plasma biomarker for metabolic-associated fatty liver disease (MAFLD) in dysglycemic context.
circulation_biomarker_prognosis_ns	36835272	hsa-mir-411	Atrial Fibrillation	In conclusion, circulating miR5p could be a valuable prognostic biomarker for MACE in AF patients.
other	36835029	hsa-mir-21	Carcinoma, Pancreatic Ductal	In this study, we focused on the expression of miR-21, -96, -196a, -210, and -217 in normal fibroblasts, cancer-associated fibroblasts prepared from a ductal adenocarcinoma of the pancreas, and pancreatic carcinoma cell lines.
other	36834999	hsa-mir-23a	Infertility, Female	Overall, our findings point to MEIS1 as a common transcription repressor of miR-23a and NORHA, and develop the miR-23a/NORHA axis into a small regulatory network regulating GC apoptosis and female fertility.
other	36834756	hsa-mir-21	Head and Neck Neoplasms	Of all miRNAs assessed, only upregulation of miR-21 was consistently shown to be an independent predictor of poor prognosis and may thus serve as a prognostic biomarker in HNSCC.
circulation_biomarker_diagnosis_up	36834570	hsa-mir-21	Carcinoma, Hepatocellular	Upregulation of plasma hsa-miR
other	36833398	hsa-mir-143	Coronary Artery Disease	However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD.
other	36833380	hsa-let-7a-1	Stomach Neoplasms	Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death.
lncRNA target	36833372	hsa-mir-146a	psoriasis 1	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-155	Crohn Disease	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-146a	Crohn Disease	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-155	psoriasis 1	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
other	36833357	hsa-mir-223	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-149	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-196	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-499	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-155	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36831939	hsa-mir-21	Stomach Neoplasms	In the present research work, the state-of-art label-free electrochemical genosensing platform was developed based on the hybridization process in the presence of [Fe(CN)(6)](3-/4-) as an efficient redox probe for sensitive recognition of the miRNA-21 in human gastric cell lines samples.
other	36831894	hsa-mir-425	Glioblastoma	5p showed the highest consistency in an upregulation in all three GSCs.
other	36831695	hsa-mir-92a	Colorectal Neoplasms	HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer.
other	36831632	hsa-mir-21	Prostatic Neoplasms	MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer.
other	36831624	hsa-mir-27a	Breast Neoplasms	This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients.
other	36831624	hsa-mir-196a	Breast Neoplasms	This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients.
other	36831545	hsa-mir-218	Lung Neoplasms	CONCLUSION: Our study highlights the vital role of the miR5p/EGFR signaling pathway in arsenic-induced carcinogenesis and angiogenesis, which may be helpful for the treatment of lung cancer induced by chronic arsenic exposure in the future.
lncRNA target	36831485	hsa-mir-34a	Colorectal Neoplasms	We have previously identified p53 and its target miR-34a, as critical determinants of the effect of hypoxia on colorectal cancer (CRC). Here we characterized the XBP-1(S) transcription factor and its regulator IRE1A as direct, conserved miR-34a targets in CRC cells.
genetics_overexpression_promote	36831315	hsa-mir-181b-2	Malformations of Cortical Development, Group II	As irradiation reduced the viability and proliferation of NSCs, whereas the overexpression of SOX21 restored the impaired cell viability and promoted the proliferation of NSCs, the findings suggest that the radiation-induced interaction of miR-181b3p with SOX21 may play dual roles in microglia and NSCs, respectively, leading to the impairment of brain neurogenesis.
circulation_biomarker_diagnosis_ns	36831306	hsa-mir-451a	Atrial Fibrillation	Receiver operating characteristic curve analysis showed that miR-451a in left atrium plasma could predict atrial fibrillation recurrence after pulmonary vein isolation. Our data suggest that miRNA-451a expression plays an important role in AF recurrence by controlling fibrosis and progression.
other	36831107	hsa-mir-1271	Thoracic Aortic   Dissection	CONCLUSIONS: The hsa_circ_0007386/miR5P/IGF1R/AKT axis may aggravate the progression of TAD by inducing VSMCs apoptosis.
other	36831100	hsa-mir-675	Breast Neoplasms	3p showed the maximal AUC of 1.000.
other	36831100	hsa-let-7	Breast Neoplasms	This study aims to investigate the relative quantification of long non-coding RNA (lncRNA) H19, microRNA (miR) 675-5p, 675-3p, and miR-let 7 in breast cancer patients.
other	36830824	hsa-mir-28	Dry Eye Syndromes	We previously reported anti-miR-328 therapy for dry eye disease (DED).
other	36830652	hsa-mir-106a	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-106a	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-21	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-21	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-146a	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-146a	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36829221	hsa-mir-421	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829221	hsa-mir-550a	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829221	hsa-mir-550a-1	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829193	hsa-mir-204	Mucocutaneous Lymph Node Syndrome	5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level.
other	36829193	hsa-mir-524	Mucocutaneous Lymph Node Syndrome	5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level.
other	36829181	hsa-mir-182	Breast Neoplasms	We identified a feedback loop with the composition of miR5p, CMTM7, CTNNA1, CTNNB1 (beta-catenin), and TCF3, which play essential roles in breast cancer progression.
other	36828974	hsa-mir-185	Diabetic Nephropathies	For the first time, we identified circRNA_0017076 as a sponge for miR5p, which regulates STIM1 gene expression and is involved in RIF.
circulation_biomarker_diagnosis_ns	36827064	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	5p levels are significantly increased in the circulating blood of NSCLC patients.
lncRNA target	36827049	hsa-mir-6785	Colorectal Neoplasms	Our study identified and primarily validated the hsa_circ_0046430/miR5p/SRCIN1 regulatory axis impacted on CRC prognosis, suggesting novel biomarkers and therapeutic targets for CRC patients.
genetics_knock down_promote	36826778	hsa-mir-101	Thyroid Cancer, Papillary	3p, and overexpressed HMGB1 almost reverted the inhibitory impacts induced by miR
other	36826008	hsa-mir-146a	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
other	36826008	hsa-mir-215	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
other	36826008	hsa-mir-29a	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
genetics_knock down_promote	36825753	hsa-mir-5195	Ovarian Neoplasms	3p significantly suppressed cell proliferation, cell cycle G1/S transition, migration and invasion in OC cell lines (SKOV-3 and OVCAR3), while knockdown of miR
circulation_biomarker_diagnosis_up	36825718	hsa-mir-103	Osteoporosis	METHODS: Plasma samples of 66 OP patients and 66 healthy controls were collected to prepare RNA samples, followed by RT-qPCR to detect the expression of circPRKCI and miR-103.
transcription factor target	36825546	hsa-mir-21	Breast Neoplasms	miR-21 and TGF-beta expression levels showed upregulation in patients with BC and elevated miR-21/TGF-beta levels consistent with the BC stage. This study suggested that miR-21 and MEG-2 can be used as prospective diagnostic biomarkers and emphasized the crucible role of TGF-beta as therapeutic targets for BC.
transcription factor target	36825443	hsa-mir-339	Vasculitis	3p targets the 5'UTR of NFATc3 mRNA to increase the protein level of NFATc3, thereby aggravating the occurrence of vascular inflammation.
lncRNA target	36824247	hsa-mir-217	Asthma	Meanwhile, functional assays and animal experiments demonstrated that lncRNA NEAT1 regulated GATA3 expression through sponge miR-217, thereby regulating Th1/Th2 balance in CD4+T cells in pediatric asthma. CONCLUSION: lncRNA NEAT1/miR-217/GATA3 axis may reveal the immunological mechanism of pediatric asthma, which has potential clinical application value in the future.
target gene	36824234	hsa-mir-885	Stomach Neoplasms	Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis.
other	36823980	hsa-mir-5739	Muscular Diseases	Importantly, abnormal expression of miR-5739 was detected in somatic cells derived from patients with congenital muscle disease.
lncRNA target	36823651	hsa-mir-525	Osteoarthritis	CONCLUSIONS: LINC00313 inhibited the development of OA through regulating miR5p/GDF5 axis.
genetics_knock down_promote	36823512	hsa-mir-139	Carcinoma, Cutaneous, Squamous Cell	5p inhibition reversed the repressive effect of circ_0068631 knockdown on CSCC cell progression.
genetics_overexpression_promote	36820950	hsa-mir-26b	Nasopharyngeal Carcinoma	Differential analysis of miRNA dataset showed that the expression of miR-26b was significantly downregulated in NPC, in agreement with the validation results of nasopharyngeal carcinoma cell lines. MiR-26b downregulation leads to CEP135 overexpression and NF-kappaB pathway activation in NPC, which enhances proliferation, migration, and prevents apoptosis of nasopharyngeal carcinoma cells.
genetics_knock down_promote	36820067	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway.
transcription factor target	36819593	hsa-mir-155	Irritable Bowel Syndrome	5p participated in the pathogenesis of IBS, at least in part by inhibiting CLDN1 and ZO-1 expression, indicating that miR
transcription factor target	36819582	hsa-mir-194	Squamous Cell Carcinoma of Head and Neck	Also, hsa-miR5p was found to contribute to the poor prognosis of OSCC by regulating CHD4 and enhancing tumor anoikis resistance via the PI3K/AKT signaling pathway.
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-21	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-548ar	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-142	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819541	hsa-mir-17	Myocardial Infarction	3p was negatively correlated with circ_0049271 in the AMI blood samples.
lncRNA target	36819499	hsa-mir-23a	Ovarian Neoplasms	lncRNA GAS5 also decreases OC progression by upregulating WT1 and attenuating miR-23a, suggesting that it could be an advantageous therapeutic target for OC intervention.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-107	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-379	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-103	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-219a-2	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
exosome	36818289	hsa-mir-218	Dmd-Associated Dilated Cardiomyopathy	Mechanistically, we identified the upregulation of miRNA5p in the DCM-Exos as a critical contributor to fibrogenesis.
target gene	36817669	hsa-mir-1286	Lung Neoplasms	MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2.
transcription factor target	36817393	hsa-mir-182	Graves Ophthalmopathy	CONCLUSIONS: ELF3/miR-182/TSHR axis alleviated Graves' orbitopathy by inhibiting adipogenic differentiation.
lncRNA target	36816363	hsa-mir-27a	Colorectal Neoplasms	The direct targeting of miR-27a-3p by ADAMTS9-AS2 abrogated the latter's effect in CRC cells.
other	36816358	hsa-mir-107	Breast Neoplasms	The PTEN/AKT signaling pathway may be regulated by miR-107 to limit breast cancer cell growth and increase apoptosis, which suggests that miR-107 may be exploited as a tumor marker for therapeutic therapy.
target gene	36816357	hsa-mir-155	Carcinoma, Hepatocellular	LncRNA CASC2 Regulate Cell Proliferation and Invasion by Targeting miR-155/SOCS1 Axis in Hepatocellular Carcinoma.
genetics_overexpression_suppress	36815970	hsa-mir-191	Adenomyosis	MIR503HG directly targeted miR-191 that was highly expressed in endometrial tissues derived from patients with AD. Collectively, overexpressed MIR503HG impeded the proliferation and migration of ESCs derived from endometrium of patients with AD, while promoting apoptosis via inhibition of the Wnt/beta-catenin pathway via targeting miR-191.
circulation_biomarker_diagnosis_up	36815956	hsa-mir-519d	Coronary Artery Disease	METHODS: The expression level of miR-22, miR-30c, miR-145, miR-519d, interleukin 6 (IL-6), and transforming growth factor beta (TGF-) was determined in peripheral blood mononuclear cells (PBMCs) from 46 patients with CAD and 39 healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay.
lncRNA target	36815949	hsa-mir-137	Lupus Erythematosus, Systemic	Furthermore, miR-137 inhibitor intervention induced healthy CD4+ T cell pyroptosis and apoptosis via mediating AMPK, whereas miR-137 mimic transfection into CD4+ T cells of SLE patients leads to opposite results.
genetics_GWAS	36815649	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	LncRNA MCM3AP-AS1 enhances cell invasion, migration and tumor formation in non-small cell lung cancer cells by epigenetic inhibition of miR-34a.
other	36815359	hsa-mir-195	Breast Neoplasms	Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown.
other	36815359	hsa-mir-497	Breast Neoplasms	Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown.
genetics_overexpression_promote	36815253	hsa-mir-665	Adenocarcinoma of Lung	PTPRB overexpression offsets the pro-proliferative potential of miR-665 in LUAD cells.
other	36814857	hsa-mir-124	Periodontitis	The study was designed to examine the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miRNA-124 in the differentiation of osteoclasts, to provide new clues or evidences for the pathogenesis of periodontitis.
other	36814556	hsa-mir-24	Nasopharyngeal Carcinoma	3p/GAD1 axis is converged to modulate the growth, migration, and invasion of NPC cells.
target gene	36814555	hsa-mir-4757	Lung Neoplasms	miR-4757-3p Inhibited the Migration and Invasion of Lung Cancer Cell via Targeting Wnt Signaling Pathway.
other	36814316	hsa-let-7f	Schimke immunoosseous dysplasia	Moreover, we found that SI gammadelta T cells shaped the gut microbiota and regulated intestinal homeostasis by secreting the fecal micro-RNA let-7f.
lncRNA target	36814156	hsa-mir-141	Prostatic Neoplasms	3p suppressed the tumor growth of PCa in vivo.
lncRNA target	36814152	hsa-mir-361	Alzheimer Disease	In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR3p.
lncRNA target	36813149	hsa-mir-199a	Stomach Neoplasms	The conspicuously increased expression of DDR2 was found in GC cell lines, luciferase reporter assays verified that miR-199a-3p directly targeted DDR2 gene, which was correlated to tumor progression. CONCLUSION: Phenotype screens and disseminated verifications incriminating in GC exposit the miR-199a-3p-DDR2-mTOR-SOX2 axis as a clinically actionable target for tumor PM progression.
genetics_knock down_promote	36813147	hsa-mir-146b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: Our results revealed that CAF-derived exosomes contained higher levels of miR-146b-5p than NFs, and miR-146b-5p overexpression in exosomes promoted the malignant phenotype of OSCC by targeting HIPK3.
other	36813098	hsa-mir-1	Li-Fraumeni Syndrome	In addition, we found a positive association between miRNA3p and LF (beta = 0.039, 95% CI = 0.002, 0.080).
transcription factor target	36812841	hsa-mir-124	Pneumonia	3p or activation of the p38MAPK pathway reversed the alleviative effect of CGA on pneumonia in vitro.
lncRNA target	36812568	hsa-mir-4299	Triple Negative Breast Neoplasms	CONCLUSION: In general, the findings suggest that lncRNA AC093850.2 was closely related to the prognosis and progression of TNBC by sponging miR-4299, which might be a prognosis predictor and potential target for treating TNBC patients.
other	36812225	hsa-mir-155	Sepsis	5p, could be useful biomarkers for detecting sepsis.
other	36811957	hsa-mir-181c	Squamous Cell Carcinoma of Head and Neck	Meanwhile, circFNDC3B sequestered miR-181c-5p to upregulate SERPINE1 and PROX1, which drove epithelial-mesenchymal transition (EMT) or partial-EMT (p-EMT) in OSCC cells and promoted lymphangiogenesis to accelerate lymph node metastasis.
other	36811541	hsa-mir-34a	Neuroblastoma	5p expression involved in regulating p53-mediated pathway are also considered.
other	36811541	hsa-mir-137	Neuroblastoma	5p expression involved in regulating p53-mediated pathway are also considered.
other	36811533	hsa-mir-125b-2	Breast Neoplasms	Patients with a luminal BC showing higher levels of miR-125b-2 and miR-320a expression before therapy demonstrated better response to NHT with tamoxifen. CONCLUSIONS: The high levels of miR-125b-2, -155, -221, and -320a in tumor tissue are associated with the HER2/neu-positive status of luminal BC subtypes.
target gene	36811283	hsa-mir-6838	Breast Neoplasms	Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p.
epigenetics	36811277	hsa-mir-92a	Pancreatic Carcinoma	Taken together, our data suggest that targeting DNA methylation and miR-92a-3p-mediated repression of HIP1R could serve as novel therapeutic strategies for PAAD treatment.
lncRNA target	36811210	hsa-mir-625	Carcinoma, Hepatocellular	3p/PDLIM5 axis inhibits the development of HCC.
genetics_knock down_promote	36811106	hsa-mir-106a	Laryngeal Neoplasms	The migration and invasion ability of the LC cells was decreased after the miR-106a-5p knockdown.
circulation_biomarker_diagnosis_down	36810972	hsa-mir-1184	Myocardial Infarction	In AMI serum, circHSPG2 and MAP3K2 mRNA were highly expressed and miR-1184 was down-regulated.
other	36810892	hsa-mir-105	Glioma	5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro.
other	36810892	hsa-mir-9	Glioma	5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro.
exosome	36810326	hsa-mir-204	Glioblastoma	3p tends to be sorted into exosomes.
transcription factor target	36810285	hsa-mir-17	Colorectal Neoplasms	5p contributes to chemotherapy sensitivity in CRC via m(6)A modification is unclear.
lncRNA target	36809926	hsa-mir-101	Transfusion Reaction	Inhibition of miR
lncRNA target	36809926	hsa-mir-101	Hepatitis A	Inhibition of miR
lncRNA target	36809926	hsa-mir-101	Aortic Valve Disease	The finding is important as it reveals that miR-1013p may be a potential therapeutic target for calcific aortic valve disease.
genetics_overexpression_suppress	36809792	hsa-mir-23a	Polycystic Ovary Syndrome	RESULTS: miR-23a-3p was poorly expressed but HMGA2 was overexpressed in GCs of patients with PCOS.
transcription factor target	36809604	hsa-mir-483	Meningioma	CONCLUSION: Meningioma cell growth is critically dependent on autocrine miR-483/IGF-2 stimulation and the IGF-2 pathway provides a feasible meningioma treatment target.
genetics_overexpression_promote	36809521	hsa-mir-194	Osteosarcoma	HK2 overexpression weakened the inhibiting impacts of miR
transcription factor target	36809070	hsa-mir-29b-2	Respiratory Distress Syndrome	In the current study, we provide evidence that AhR activation can attenuate LPS-mediated ARDS through the activation of Th22 cells in the lungs, which are regulated through miR-29b5p.
lncRNA target	36808502	hsa-mir-499	familial febrile seizures 1	It also upregulated SIRT1/PGC-1alpha/Nrf1/TFAM profiles at both gene and protein levels, Mfn2 protein, and microRNA-499 expression, and downregulated Drp1 protein and Beclin1, LC3, and p62 genes (P < .05 to P < .001). Co-application of NMN/melatonin within the setting of I/R injury in the aged rat heart induced noticeable cardioprotection through modulation of a coordinated network including microRNA-499 expression along with mitochondrial biogenesis associated with SIRT1/PGC-1alpha/Nrf1/TFAM profiles, mitochondrial fission/fusion, and autophagy, therefore, appears to prevent the burden of myocardial I/R injury in elderly patients.
transcription factor target	36808485	hsa-mir-3529	Adenocarcinoma of Lung	The underlying mechanism may be that MSA alleviates hypoxia and has synergistic effects in cellular ROS promotion with miR
other	36808381	hsa-mir-34a	Fibrosis	In conclusion, our study indicated that the p53/miR-34a axis promotes the development of renal fibrosis.
genetics_knock down_promote	36808302	hsa-mir-579	gastric adenocarcinoma	Accordingly, cell proliferation, cholesterol synthesis and SQLE expression were significantly inhibited by circ_0000182 knockdown in STAD cells, and these effects were partly reversed by miR
lncRNA target	36808266	hsa-mir-1249	Carcinoma, Non-Small-Cell Lung	In vivo assay showed that circ_0001715 promoted the NSCLC progression through the miR
other	36807979	hsa-mir-122	Hepatitis C	Efficient hepatitis C virus (HCV) RNA accumulation is dependent upon interactions with the human liver-specific microRNA, miR-122.
lncRNA target	36807469	hsa-mir-138	Stomach Neoplasms	5p/PLAGL2 molecular signaling axis in GC, and our findings provide enlightenment for further understanding of the mechanism of tumorigenesis and development of GC, making LGALS8-AS1 a possible new diagnostic or therapeutic target for GC.
circRNA target	36807271	hsa-mir-1205	Breast Neoplasms	The expression of circ_0137652, miR-1205, and CCNB1 in BC tissues and cell lines were detected using RT-qPCR and/or western blotting. Furthermore, miR-1205 inhibits BC progression by targeting CCNB1.
lncRNA target	36806318	hsa-mir-200b	Carcinoma, Non-Small-Cell Lung	Furthermore, LncRNA ATB depletion suppressed NSCLC cells proliferation, migration and invasion, while miR-200b inhibitor or pcDNA-FN1 rescued these effects. CONCLUSION: In summary, our outcomes elucidated that LncRNA ATB/miR-200b axis expedited NSCLC cells proliferation, migration and invasion by up-regulating FN1.
lncRNA target	36806251	hsa-mir-525	Osteoarthritis	5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-kappaB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA.
transcription factor target	36806218	hsa-mir-144	Carcinoma, Hepatocellular	3p/FOXK1 axis repressed malignant progression of HCC via affecting the aerobic glycolytic process of HCC cells.
lncRNA target	36806197	hsa-mir-187	Embryo Loss	In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX.
lncRNA target	36806197	hsa-mir-187	Anovulation	miR-187, a miRNA down-regulated during follicular atresia in sows, maintains TGFBR2 mRNA stability in sow GCs by directly binding to its 5'-UTR. In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX.
other	36806086	hsa-mir-29a	Prostatic Neoplasms	These findings proved that the important role of miR-29a-5p in prostate cancer ferroptosis.
other	36805538	hsa-mir-183	Stomach Neoplasms	p-regulation of microRNA-183 reduces FOXO1 expression in gastric cancer patients with Helicobacter pylori infection.
transcription factor target	36805456	hsa-mir-23b	Arthritis, Rheumatoid	Following the intravenous injection of FP/miR-23b nanoparticles in experimental RA models, the nanoparticles show therapeutic efficacy with inhibition of inflammatory response, reduced bone and cartilage erosion, suppression of synoviocyte infiltration and the recovery of mobility.
other	36804532	hsa-mir-455	Pneumonia, Mycoplasma	Bioinformatics analysis confirmed that decidual stromal cells derived from PE patients expressed significantly lower miR3p than those derived from healthy donors.
target gene	36804476	hsa-mir-10a	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
target gene	36804476	hsa-mir-217	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
target gene	36804476	hsa-mir-512	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
exosome	36804284	hsa-mir-20b	Brain Injuries, Traumatic	Furthermore, high level of microglial exosomal miR-20b-5p induced by mild hypothermia could transfer into injured neurons and promote neurite outgrowth and synapse recovery after TBI via activating the PI3K-AKT pathway by suppressing PTEN expression.
other	36803590	hsa-mir-192	Myelodysplastic Syndromes	CONCLUSIONS: This study shows that high levels of miR5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide.
other	36803590	hsa-mir-192	Leukemia	5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide.
other	36802524	hsa-mir-155	Breast Neoplasms	Furthermore, the biosensor could discriminate breast cancer patients evidently by analyzing exomiR-155, and these results conformed to that of qRT-PCR.
genetics_knock down_suppress	36802224	hsa-mir-1236	Pneumonia	CONCLUSION: Circ_0099188 knockdown might mitigate LPS-induced HPAEpiC cell injury by targeting the miR3p/HMGB3 axis, providing an underlying therapeutic strategy for pneumonia treatment.
lncRNA target	36801666	hsa-mir-4731	Breast Neoplasms	CONCLUSION: Collectively, BCSCs-EVs-mediated delivery of ARRDC1-AS1 may promote the malignant phenotypes of BC cells via the miR
other	36801567	hsa-mir-16	Cardiomegaly	In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy.
other	36801567	hsa-mir-15a	Cardiomegaly	In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy.
lncRNA target	36801509	hsa-mir-539	Colorectal Neoplasms	Mechanistically, we found that TP73-AS1 targeted miR
lncRNA target	36801505	hsa-mir-877	Breast Neoplasms	In summary, TRG-AS1 acts an endogenous RNA, inhibited breast cancer bone metastasis by competitively binding with miR5p to upregulate WISP2 expression.
circulation_biomarker_prognosis_up	36801489	hsa-mir-132	Epilepsy	3p serum levels performed better than each separately as a diagnostic biomarker to distinguish epilepsy patients from controls.
lncRNA target	36801480	hsa-mir-34a	Bone-Associated Metastatic Breast Cancer	MicroRNA-34a (miRNA-34a) is a promising anti-cancer miRNA for gene therapy to bone metastatic cancer patients. The results of experiments in vitro and in vivo confirmed that the constructed bone-targeted miRNA delivery system PCA/miR-34a can enhance the anti-tumor efficacy in bone metastatic cancer, and provide a potential strategy for gene therapy in bone metastatic cancer.
circRNA target	36801359	hsa-mir-344	Anxiety Disorders	5p might be new targets for the treatment of stress-related disorder.
other	36801359	hsa-mir-344	Memory Disorders	And miR5p mimics could simulate the dendritic spine density reduction, depressive- and anxiety-like behaviors and memory impairment induced by CUMS.
circRNA target	36801359	hsa-mir-344	Stress Disorders, Traumatic	These findings represent the first evidence for the involvement of circSYNDIG1 and its coupling mechanism in depression and anxiety, suggesting that circSYNDIG1 and miR5p might be new targets for the treatment of stress-related disorder.
circRNA target	36801359	hsa-mir-344	Neurotic Disorders	5p might be new targets for the treatment of stress-related disorder.
lncRNA target	36800936	hsa-mir-181a	Squamous Cell Carcinoma of Head and Neck	Moreover, upregulated miR-181a-5p significantly inhibited OSCC cell proliferation, colony formation, invasion, and migration; blocked the cell cycle; and promoted apoptosis.
other	36800843	hsa-mir-199a	Diabetic Nephropathies	Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control.
other	36800843	hsa-mir-199a	Lupus Nephritis	Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control.
other	36800843	hsa-mir-155	Lupus Nephritis	Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients.
other	36800843	hsa-mir-155	Diabetic Nephropathies	Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients.
other	36800833	hsa-mir-223	Sepsis	3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia.
other	36800833	hsa-mir-7110	Sepsis	3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia.
other	36800817	hsa-mir-193a	Endometrial Neoplasms	3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients.
other	36800817	hsa-mir-128	Endometrial Neoplasms	3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients.
other	36800601	hsa-mir-5703	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-652	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-3125	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-513c	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
lncRNA target	36800052	hsa-mir-450b	Osteoporosis	IRF-1 promoted the osteogenic differentiation via mediation of lncRNA XIST/miR-450b/FBXW7 axis, and this finding might shed novel insights on exploring new ideas against osteoporosis.
other	36799446	hsa-mir-125b	Liver Cirrhosis	In vitro, SCT 5-27 treatment of a human biliary PSC cell line decreased proliferation and senescence and SR/TGF-beta1/VEGF-A axis but increased the expression of miR-125b and FoxA2.
genetics_overexpression_promote	36799424	hsa-mir-940	Uterine Cervical Neoplasms	RESULTS: Hsa_circ_0000021 and KPNA2 were overexpressed and inversely associated with the levels of miR
genetics_overexpression_promote	36799154	hsa-mir-29a	Glioma	By conducting hypoxia experiments in vitro on U251 glioma cells, it was found that the expression level of miR29a3p decreased following hypoxia, while overexpression of miR29a3p significantly decreased the proliferation of U251 glioma cells and promoted apoptosis by inhibiting the expression of the antiapoptotic marker Bcl2 and increasing the expression of the proapoptotic marker Bax The potential targets of miR29a3p were predicted by online tools and validated by a dualluciferase gene reporter assay.
other	36798914	hsa-mir-29a	Diabetic Nephropathies	RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats.
other	36798914	hsa-mir-377	Diabetic Nephropathies	RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats.
other	36798788	hsa-mir-122	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-95	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-204	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-552	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798467	hsa-mir-200	Brain Neoplasms	However, currently, there is no known therapeutic role for miR-200 family members in the setting of BM.
circulation_biomarker_diagnosis_ns	36798431	hsa-mir-21	Pancreatic Carcinoma	Here, we refined the original method by simultaneously measuring the serum miR5p level to enhance the detection of PDAC.
genetics_knock down_promote	36797846	hsa-mir-1299	Esophageal Squamous Cell Carcinoma	All experimental data showed that knockdown of circPPFIA1 contributed to radiosensitivity in ESCC by inducing miR
genetics_overexpression_promote	36797791	hsa-mir-128	Stomach Neoplasms	Overexpressed TUFT1 reduced miR
other	36797674	hsa-mir-758	Migraine Disorders	5p) novel signature has been found differentially expressed between controls and patients with migraine.
other	36797674	hsa-mir-342	Migraine Disorders	5p) novel signature has been found differentially expressed between controls and patients with migraine.
genetics_knock down_promote	36797317	hsa-mir-1270	Pancreatic Carcinoma	The repressive effects of NR3C1 knockdown on PC cell malignant phenotypes were partly abolished by miR-1270 inhibition.
genetics_overexpression_promote	36796652	hsa-mir-125b	Glioma	Mechanistic studies revealed that circ101491 upregulated EDN1 expression through sponging miR-125b-5p, thus facilitating glioma progression. In summary, hypoxia could promote circ101491 overexpression in glioma cell-derived exosomes, and circ101491/miR-125b-5p/EDN1 regulatory axis might be implicated in the malignant progression of glioma.
lncRNA target	36796622	hsa-mir-1278	Glioma	These findings display that circPKD2 can function as a tumor suppressor in glioma by controlling the miR-1278/LATS2 axis and provide the potential biomarkers for glioma treatment.
lncRNA target	36796497	hsa-mir-214	Nephritis, Interstitial	3p attenuates T-2 toxin-induced chondrocyte apoptosis and ECM degradation through a potential NF-kappaB signaling pathway.
genetics_overexpression_promote	36796259	hsa-mir-149	psoriasis 1	CONCLUSION: The overexpressed miR
other	36795778	hsa-mir-489	Diabetic Retinopathy	CONCLUSION: This study demonstrated that a TPTEP1/miR3p/NRF2 axis affects the development of DR by regulating oxidative stress.
transcription factor target	36795153	hsa-mir-18a	Brain Injuries	Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH.
transcription factor target	36795153	hsa-mir-18a	Subarachnoid Hemorrhage	Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH.
lncRNA target	36794620	hsa-mir-499a	Colorectal Neoplasms	Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing.
lncRNA target	36794620	hsa-mir-6769b	Colorectal Neoplasms	Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing.
other	36794154	hsa-mir-155	Chronic Disease	Conclusion: IL-10 downregulated miR-155 and activated SOCS5, thereby promoting macrophage M2 polarization to relieve chronic rejection after heart transplantation.
other	36793717	hsa-mir-25	Tuberculosis	3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network.
other	36793717	hsa-mir-150	Tuberculosis	3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network.
other	36793496	hsa-mir-34c	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
other	36793496	hsa-mir-20a	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
other	36793496	hsa-mir-338	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
exosome	36793374	hsa-mir-370	Uterine Cervical Neoplasms	The positive feedback loop of exosomal MALAT1/miR-370-3p/STAT3 mediates the cisplatin resistance of cervical cancer cells affecting PI3K/Akt pathway.
other	36793126	hsa-mir-146b	Colorectal Neoplasms	Moreover, we found that miR-146b-3p could be a key regulator for vascular endothelial cell dysfunction.
genetics_overexpression_suppress	36793115	hsa-mir-218	Osteoporosis	5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR
genetics_overexpression_suppress	36793115	hsa-mir-218	Pars Planitis	5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR
lncRNA target	36793108	hsa-mir-130a	Carcinoma, Non-Small-Cell Lung	The in vitro findings were reproduced in vivo, where ITF2357 inhibited the HDAC2/miR-130a-3p/Rad51 axis to reduce the resistance of mut-KRAS NSCLC to Pem. CONCLUSION: Taken together, HDAC inhibitor ITF2357 restores miR-130a-3p expression by inhibiting HDAC2, thereby repressing Rad51 and ultimately diminishing resistance of mut-KRAS NSCLC to Pem.
other	36792543	hsa-let-7a	Breast Neoplasms	Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively.
other	36792543	hsa-mir-21	Breast Neoplasms	Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively.
transcription factor target	36791645	hsa-mir-181a-2	Colorectal Neoplasms	In line with this, the miR-181a3p inhibitor transfection could increase tumorigenicity of NRF2-silenced colorectal cancer cells.
transcription factor target	36791628	hsa-mir-96	Liver Diseases	Data from small RNA sequencing and bioinformatics analysis reveal that miR-396e, one of the most abundant miRNAs of GDE, is the key component to regulate PFKFB3 expression. Mechanistically, miR-396e-mediating PFKFB3 expression plays a crucial role in GDE inhibiting inflammatory response and enhancing lipid metabolism in hepatocytes via the macrophage-hepatocyte crosstalk.
other	36791156	hsa-mir-1262	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-548o	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-205	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-125b-2	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-let-7b	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
circRNA target	36790665	hsa-mir-497	Prostatic Neoplasms	Our finding revealed that circ_0085494 downregulation might repress PCa tumor progression through in part regulating the miR
lncRNA target	36789845	hsa-mir-483	Myocardial Infarction	3p) to inhibit hypoxia-induced myocardial infarction.
genetics_overexpression_suppress	36789845	hsa-mir-483	Hypoxia	Overexpression of miR
genetics_knock down_suppress	36789690	hsa-mir-96	Cardiomyopathies	5p knockdown using antagomir alleviates the aggravated cardiac fibrosis and exacerbated myocardial function caused by myocardial infarction surgery as shown by the echocardiography and Masson's staining analysis.
lncRNA target	36788697	hsa-mir-370	Inflammation	MiR3p mimics inhibited XIST's effect on inflammation, viability, and apoptosis.
circulation_biomarker_diagnosis_up	36788514	hsa-mir-424	Pre-Eclampsia	METHODS: Blood pressure and 24-h proteinuria of patients with preeclampsia (PE) were measured as well as the levels of miR
genetics_overexpression_promote	36787443	hsa-mir-378a	Ventricular Premature Complexes	TGF-beta1 treatment led to an upregulation of CTGF since early VC but not miR-378a-3p until mid-term VC, while miR-378a-3p overexpression suppressed CTGF expressions without altering TGF-beta1 levels.
circulation_biomarker_diagnosis_ns	36787323	hsa-mir-122	Aortic Aneurysm, Abdominal	CONCLUSION: Plasma exosomes from AAA patients have significantly reduced levels of miRNA5p compared to controls.
genetics_knock down_promote	36787056	hsa-mir-545	Adenocarcinoma of Lung	3p inhibitor partially abolished the inhibition function of lncRNA PCAT6 knockdown on LUAD cells.
exosome	36786721	hsa-mir-183	Chemical and Drug Induced Liver Injury	Moreover, in vivo experiments confirmed that miR-183 and exosomes from ADSCs could improve liver injury in rats and inhibit the MAPK and NF-kappaB pathways. All of these findings demonstrate that exosomes derived from ADSCs have a significant protective effect on hepatic I/R injury by regulating the miR-183/ALOX5 axis, which might provide a therapeutic strategy for liver injury.
other	36786410	hsa-mir-431	Carcinoma, Hepatocellular	CircADSS could regulate HCC cell malignancy by miR5p/TOP2A axis.
lncRNA target	36786348	hsa-mir-450b	Carcinoma, Hepatocellular	Collectively, Silencing HCG18 inhibits GPX4 by binding to miR-450b-5p, promotes GPX4-inhibited ferroptosis, and averts sorafenib resistance in HCC.
genetics_GWAS	36786137	hsa-mir-146a	Gout	METHOD: A case-control study was performed in this report to examine the potential association between gout and the functional rs57095329 SNP of miR-146a in a Chinese population consisting of 448 primary gout patients (containing 76 tophi patients) and 418 healthy controls.
lncRNA target	36785792	hsa-mir-132	Myocardial Infarction	CONCLUSIONS: The current study revealed the critical role of the MBNL1-AS1/miR3p/RAB14/CAMTA1 axis in MI, indicating MBNL1-AS1 as an innovative therapeutic target for MI.
other	36785666	hsa-mir-1321	Pancreatic Carcinoma	Downregulating LINC01503 promoted the availability of miR-1321 in pancreatic cancer cells and thus repressed KLK4 expression.
other	36782343	hsa-mir-433	Osteosarcoma	CONCLUSIONS: Overall, PCGEM1 mediated tumor growth and metastasis of OS by sponging miR3p and regulating OMA1, which might provide an innovative strategy for OS diagnosis or treatment.
lncRNA target	36782115	hsa-mir-130b	Acute Lung Injury	We have previously discovered that microRNA 130b-3p inhibits eCIRP mediated inflammation.
lncRNA target	36781680	hsa-mir-449a	Fibrosis, Renal	Therefore, miR-449a might act as a target in treating RIF.
genetics_overexpression_suppress	36781583	hsa-mir-18a	Osteochondritis Dissecans	ACVR2B served as a direct target of miR-18a-5p, and ACVR2B overexpression might abolish the inhibitory role of miR-18a-5p on OGD/R-treated HBMEC injury.
target gene	36781484	hsa-mir-1298	Polycystic Ovary Syndrome	MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase.
exosome	36781343	hsa-mir-142	Atrial Premature Complexes	These data demonstrate that propofol inhibits osteogenic differentiation and mineralization of MSCs induced by PCa-derived exosomes by regulation of miR
other	36781308	hsa-mir-133a	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781308	hsa-mir-206	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781308	hsa-mir-133b	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781251	hsa-mir-132	Depression	Herein, we developed a bidirectional-motivated bimodal isothermal strand displacement amplifier (BB-ISDA) for the ultrasensitive fluorescent and colorimetric detection of MDD-related miRNA-132.
transcription factor target	36781060	hsa-mir-149	Brain Ischemia	5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability.
transcription factor target	36781060	hsa-mir-204	Brain Ischemia	5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability.
genetics_GWAS	36780761	hsa-let-7	Ischemic Stroke	Detecting let-7 promoter polymorphisms could raise awareness of the risk of IS, which directed individuals with risk alleles to have regular checks at an appropriate frequency to avoid developing the disease.
lncRNA target	36780323	hsa-mir-143	Myocardial Reperfusion Injury	3p's pathological role in the early stages of MI/RI, and inhibiting miR
other	36780058	hsa-mir-338	Carcinoma, Hepatocellular	Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis.
lncRNA target	36779980	hsa-mir-34a	Ovarian Neoplasms	Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC.
lncRNA target	36779980	hsa-mir-205	Ovarian Neoplasms	Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC.
genetics_knock down_promote	36778920	hsa-mir-1225	Carcinoma, Renal Cell	5p treatment further promoted the inhibitory ability of ARL4C knockdown.
lncRNA target	36777862	hsa-mir-34a	Inflammatory Bowel Diseases	CONCLUSIONS: Resveratrol attenuates IBD by promoting MUC2 synthesis via the ANRIL-miR-34a axis.
circulation_biomarker_diagnosis_down	36777859	hsa-mir-185	Pulmonary Disease, Chronic Obstructive	5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD.
circulation_biomarker_diagnosis_down	36777859	hsa-mir-182	Pulmonary Disease, Chronic Obstructive	5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD.
genetics_overexpression_promote	36777845	hsa-mir-145	Carcinoma, Renal Cell	circ-AFF2 and circ-ASAP1 were highly expressed in RCC patient-derived tumor samples; their overexpression correlated with poor prognosis and low miR-145 levels.
genetics_overexpression_promote	36777826	hsa-mir-26a	Cerebral Hemorrhage	In contrast, overexpression of miR-26a alleviated the neurologic damage and promoted cerebral angiogenesis in ICH rats, but these could be attenuated by TUG1 overexpression.
lncRNA target	36777638	hsa-mir-92a	Parkinson Disease	Moreover, the microRNA-TFs-mRNA network revealed that the microRNA-92a family targets all four immune-related genes in PD pathogenesis.
lncRNA target	36777518	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	PSMG3-AS1 increased OSCC cell proliferation and tumor growth and suppressed the inhibitory role of miR-141 in cell proliferation and tumor growth.
genetics_overexpression_suppress	36777504	hsa-mir-181a	Uveal melanoma	Furthermore, silencing GNAQ or AKT3 mimicked the anti-UM effects of miR-181a-5p, whereas overexpression of GNAQ or AKT3 rescued the anti-UM effects induced by miR-181a-5p.
other	36777002	hsa-mir-183	Thyroid Cancer, Papillary	5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability.
other	36777002	hsa-mir-182	Thyroid Cancer, Papillary	5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability.
lncRNA target	36776858	hsa-mir-222	Colorectal Neoplasms	The in vivo results demonstrated that inhibiting miR
lncRNA target	36776858	hsa-mir-222	Inflammatory Bowel Diseases	The in vivo results demonstrated that inhibiting miR
genetics_GWAS	36776296	hsa-mir-495	Thyroid Cancer, Papillary	RESULTS: Overexpression of miR
lncRNA target	36776216	hsa-mir-6827	Ovarian Neoplasms	5p in OC cells, which may provide a potential target and biomarker for the diagnosis or prognosis of OC.
lncRNA target	36776011	hsa-mir-223	Hepatitis B  Virus-Associated Glomerulonephritis	Objective: To investigate the potential function and related mechanism of microRNA-223 (miRNA-223) in the podocyte pyroptosis of hepatitis B virus (HBV)-associated glomerulonephritis induced by HBV X protein (HBx). Conclusion: HBx may promote podocyte pyroptosis of HBV-GN via downregulating miRNA-223 targeting NLRP3 inflammasome, suggesting that miRNA-223 is expected to be a potential target for the treatment of HBV-GN.
exosome	36775818	hsa-mir-146a	Diabetes Mellitus	Here, the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch (SFP) were demonstrated to promote diabetic wound healing.
circRNA target	36775571	hsa-mir-340	Colorectal Neoplasms	Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment.
genetics_overexpression_suppress	36775560	hsa-mir-150	Colonic Neoplasms	3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133(+)CD44(+) cells using both in vitro and in vivo assays.
lncRNA target	36775555	hsa-mir-135a	Hypoxia-Ischemia, Brain	M2 microglia-derived EVs delivered miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibited the activation of NLRP3 inflammasome, thereby reducing neuronal autophagy and ischemic brain injury. Mechanistically, M2 microglia-derived EVs deliver miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibits the activation of NLRP3 inflammasomes, thereby reducing neuronal autophagy and ischemic brain injury.
exosome	36775554	hsa-mir-21	Rett Syndrome	In the present study, we sought to determine whether that exosomal miR5p from USCs could promote early neural formation in a model of RTT.
other	36775545	hsa-mir-140	Alcoholism	Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease.
other	36775545	hsa-mir-140	Liver Injury	Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease.
lncRNA target	36775540	hsa-mir-143	Carcinoma, Non-Small-Cell Lung	3p inhibitor rescued the inhibitory effect of sh-UCC on the proliferation of NSCLC cells.
lncRNA target	36775537	hsa-mir-150	Sepsis	5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway.
lncRNA target	36775537	hsa-mir-150	Cardiomyopathies	5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway.
lncRNA target	36775498	hsa-mir-26b	Leukemia, Myeloid, Acute	This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth factor (CTGF)/vascular endothelial growth factor (VEGFA) axis via targeting miR-26b to regulate angiogenesis of acute myelogenous leukemia (AML), providing new insights into mechanisms of AML.
exosome	36775496	hsa-mir-199a	Thrombocytopenia	Supplementation of extracellular vesicles (EVs) derived from miR-199a-5p-modified ADSCs markedly repress Th17 differentiation by transferring miR-199a-5p to CD4(+)T cells, thus ameliorating experimental ITP.
transcription factor target	36775482	hsa-mir-130b	Adenocarcinoma of Lung	Hence, targeting miR-130b may serve as a potential therapeutic strategy for lung cancer. Hence, miR-130b is a potential therapeutic target for lung cancer.
target gene	36775481	hsa-mir-184	Idiopathic Pulmonary Fibrosis	miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial-mesenchymal transition of airway epithelial cells.
lncRNA target	36775475	hsa-mir-22	Hypogonadism	This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism.
lncRNA target	36775475	hsa-mir-125a	Hypogonadism	This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism.
lncRNA target	36775469	hsa-mir-214	Atrial Fibrillation	XIST then suppresses NLRP3 inflammasome activation and myocardial pyroptosis by reducing miR
circulation_biomarker_prognosis_ns	36775455	hsa-mir-221	Heart Failure	Furthermore, serum miR
genetics_overexpression_promote	36775453	hsa-mir-96	Carcinoma, Hepatocellular	5p transfection promoted proliferation, migration and invasion of SMMC-7721 and MHCC-97H hepatoma cells; whereas the function of oncogenic microRNA-96 was significantly inhibited in GPM6A-overexpressed hepatoma cells.
genetics_overexpression_promote	36775444	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1.
lncRNA target	36775436	hsa-mir-27a	Lung Injury	Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. In the present study, the authors reveal that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
lncRNA target	36775429	hsa-mir-20a	Leukemia, Myeloid, Acute	In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells.
other	36775425	hsa-mir-513a	Lupus Nephritis	Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.
circRNA target	36775423	hsa-mir-20a	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
circRNA target	36775423	hsa-mir-136	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
genetics_overexpression_promote	36775421	hsa-mir-148a	Nasopharyngeal Carcinoma	Silencing of SRGN and CREB1, as well as miR-148a-5p overexpression, repressed NPC tumor progression in vitro and in vivo.
exosome	36775383	hsa-mir-1246	Glioma	and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.
exosome	36775383	hsa-mir-10b	Glioma	and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.
genetics_GWAS	36775382	hsa-mir-138	Cartilage Diseases	This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA.
genetics_GWAS	36775382	hsa-mir-138	Osteoarthritis	This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA.
genetics_overexpression_promote	36775374	hsa-mir-34b	Asthma	Notably, EZH2 and BTG2 were significantly overexpressed, while FOXO3 and miR-34b were obviously underexpressed in asthma.
lncRNA target	36775364	hsa-mir-96	Osteoarthritis	5p expression, which results in targeting HIF-2alpha 3'-UTR sequences and inhibiting HIF-2alpha in murine cartilage tissue and chondrocytes.
target gene	36775360	hsa-mir-432	Osteosarcoma	MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB.
circulation_biomarker_diagnosis_up	36775328	hsa-mir-143	Myocardial Infarction	CONCLUSIONS: An increase in plasma miR-143 concentrations in the acute phase may be a biomarker predicting recovery of LV function in the chronic phase in AMI patients.
other	36775115	hsa-mir-663a	Lung Neoplasms	GSE and MTE additively upregulated miR-663a and FHIT in lung cancer cell lines; transfection of antisense-miR-663a significantly abrogated the anti-proliferative effects of GSE/MTE, upregulation of FHIT mRNA and protein. LP and siliphos also additively increased miR-663a and FHIT protein in lung tumor xenografts.
other	36774884	hsa-mir-296	Carcinoma, Non-Small-Cell Lung	Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.
lncRNA target	36773565	hsa-mir-144	Diabetes Mellitus, Type 2	3p dysregulation.
other	36772911	hsa-mir-494	Dmd-Associated Dilated Cardiomyopathy	The results showed that the expression level of miR-494 was higher in the myocardial tissue of DCM rats and the myocardial cells of H9c2 treated with HG.
circulation_biomarker_diagnosis_down	36771341	hsa-mir-122	Alzheimer Disease	A final binary logistic regression analysis showed that alpha-tocopherol serum levels were associated with a higher AD probability and partially mediated by miR-122.
circRNA target	36770940	hsa-mir-1268b	Atherosclerosis	In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis and TMP-PF could regulate the circSCRG1/miR-1268b/NR4A1 axis to inhibit angiogenesis in atherosclerosis in vitro, indicating a novel angiogenesis signalling circSCRG1/miR-1268b/NR4A1 pathway in atherosclerosis and the regulatory effects of TMP-PF, which might provide a new pharmaceutical strategy to combat atherosclerotic plaque instability.
target gene	36769824	hsa-mir-197	Osteosarcoma	miR-197-3p Promotes Osteosarcoma Stemness and Chemoresistance by Inhibiting SPOPL.
circulation_biomarker_diagnosis_up	36769594	hsa-mir-1	Aortic Aneurysm, Abdominal	3p expression (overall and for age &lt; 65 years, aneurysm-related death or cardiac death subgroup) when compared to alive patients; further Cox regression yielded an independent relationship of preoperative low serum miR
other	36769379	hsa-mir-145	Premature Ovarian Aging	Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed.
other	36769379	hsa-mir-143	Premature Ovarian Aging	Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed.
lncRNA target	36769373	hsa-mir-340	Nasopharyngeal Carcinoma	3p/FKBP5 network may be instrumental in regulating NPC radioresistance by enhancing autophagy, which provides potential new therapeutic targets for NPC.
other	36769354	hsa-mir-21	Rhegmatogenous Retinal Detachment, Autosomal Dominant	We found the existence of a positive association between the expression of miR-21 (p = 0.017, r = 0.515) and miR-34 (p = 0.030, r = 0.624) and the duration of symptoms related to retinal detachment.
other	36769354	hsa-mir-146a	Rhegmatogenous Retinal Detachment, Autosomal Dominant	Moreover, the expression of miR-146a tended to decrease in patients who developed PVR.
other	36769177	hsa-mir-155	Breast Neoplasms	We found that the system is capable of specific detection of miR-155, a microRNA implicated in the carcinogenesis of human breast cancer.
circulation_biomarker_diagnosis_up	36769143	hsa-mir-434	Brain Injuries, Traumatic	These included 7 brain-enriched plasma miRNAs (miR
circulation_biomarker_diagnosis_up	36769143	hsa-mir-9a	Brain Injuries, Traumatic	These included 7 brain-enriched plasma miRNAs (miR
lncRNA target	36769104	hsa-mir-212	Hypoxia	Then, we predicted the upstream miRNAs of MCM2 through TargetScan and miRanDa and selected miR
lncRNA target	36769104	hsa-mir-212	Cerebrovascular Disorders	Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease.
lncRNA target	36769104	hsa-mir-212	Opitz GBBB Syndrome, X-Linked	Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease.
other	36768818	hsa-mir-20b	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-1	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-517	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-375	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-218	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-378a	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
transcription factor target	36768805	hsa-mir-92a	Cardiac Microvascular Inflammation	Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease.
lncRNA target	36768805	hsa-mir-92a	Diabetes Mellitus	We previously characterized the cardiac microvascular inflammatory phenotype in diabetic patients and highlighted micro-RNA 92a (miR-92a) as a driver of endothelial dysfunction. Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease.
lncRNA target	36768775	hsa-mir-21	Endometriosis	The Expression of TGF-1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic The molecular pathogenesis of endometriosis has been associated with pathological alterations of protein expression via disturbances in homeostatic genes, miRNA expression profiles, and signaling pathways that play an essential role in the epithelial-mesenchymal transition (EMT) process. Compared to the endometrium of healthy participants, miR-21 expression levels did not change in the eutopic endometrium of women with endometriosis, but the RQ was higher in their endometrial implants.
other	36768614	hsa-mir-124	Diabetic Retinopathy	In rat DR, miR-124 prevents vasoregression and glial activation, improves neuroretinal function, and modulates microglial activation and inflammatory responses.
other	36768376	hsa-mir-16	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
other	36768376	hsa-mir-135	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
other	36768376	hsa-mir-135a	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
lncRNA target	36768146	hsa-mir-182	Prostatic Neoplasms	In summary, this is the first study to report that miR-182 over-expression in prostate cancer may contribute to EMT by targeting MITF expression.
circulation_biomarker_diagnosis_ns	36766808	hsa-mir-155	Acquired Immunodeficiency Syndrome	We propose that the activation of peripheral blood mononuclear cells (PBMCs) leads to an increased miR-155 expression and production of miR
lncRNA target	36766731	hsa-mir-193a	Breast Neoplasms	In conclusion, miR193a-3p can potentially modify the tumor microenvironment by altering pro-growth BC secretome and inhibiting LEC growth, and may represent a therapeutic molecule to target breast tumors/cancer.
lncRNA target	36766731	hsa-mir-193a	Bulimia Nervosa	We have recently shown that miR193a-3p, a tumor suppressor miRNA, inhibits MCF-7 BC cell-driven growth of VECs via direct antimitogenic actions and alters MCF-7 secretome.
other	36766397	hsa-mir-411b	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-1193	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-485	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-381	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-3957	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-376b	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-376c	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36765584	hsa-mir-21	Colorectal Neoplasms	Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21.
other	36765487	hsa-mir-125	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL.
other	36765487	hsa-mir-195	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL.
other	36765483	hsa-mir-424	Lymphoma, Large B-Cell, Diffuse	5p enhances the drug resistance of DLBCL cells by regulating the PD-1/PD-L1 signaling pathway.
lncRNA target	36765482	hsa-mir-20a	Lymphoma	OBJECTIVE: To investigate the effects of lncRNA HOTAIR on the proliferation, invasion and migration of lymphoma cells through target gene miR-20a-5p and its molecular mechanism. CONCLUSION: HOTAIR affects the proliferation, invasion and migration of lymphoma cells by targeting miR-20a-5p, and its mechanism may be related to the activation of JAK/STAT3 signaling pathway.
transcription factor target	36765480	hsa-mir-144	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	3p can inhibit the proliferation and promote apoptosis of K562 cells, affect the cell cycle, and block K562 cells in S phase, which indicates that miR
lncRNA target	36765401	hsa-mir-148	Stomach Neoplasms	CONCLUSIONS: This study demonstrates that the miR-148/152 family members may prevent gastric cancer stem cell-like properties by targeting ITGA5, which can serve as an appealing target for gastric cancer treatment.
other	36764873	hsa-mir-1178	Breast Neoplasms	3p and thus upregulating TMED3.
other	36764602	hsa-mir-135a	Spinal Cord Injuries	In summary, the miR-135a-5p/SP1 axis regulates astrocyte proliferation and migration after SCI.
exosome	36764461	hsa-mir-203a	Diabetes Mellitus	CONCLUSIONS: Our results demonstrated that the abundant miR-203a-3p present in EpiSC-EXOs can promote M2 macrophage polarization by downregulating SOCS3 and suggested that diabetic wounds can obtain better healing effects through this mechanism.
transcription factor target	36764280	hsa-mir-155	Rhinitis, Allergic	Therefore, our results suggest that blocking the Notch pathway may alleviate miRmediated inflammation via the regulation of immune homeostasis in AR.
transcription factor target	36764278	hsa-mir-223	Acute Liver Injury	CONCLUSIONS: SPC alleviates acute liver injury through up-regulating the expression of miR3p.
circRNA target	36764273	hsa-mir-483	Osteoporosis	In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP.
circRNA target	36764273	hsa-mir-642b	Osteoporosis	In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP.
transcription factor target	36764271	hsa-mir-34b	Myocardial Reperfusion Injury	MiR-34b-3p and Jagged1 levels were increased and decreased in myocardial I/R injury model, respectively, while Dex reversed this effect. Dex relieved the myocardial I/R injury of rats via inhibiting miR-34b-3p and further activating Notch signaling pathway.
lncRNA target	36764156	hsa-mir-100	Stomach Neoplasms	3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells.
lncRNA target	36764156	hsa-mir-145	Stomach Neoplasms	3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells.
lncRNA target	36763225	hsa-mir-199a	Lupus Erythematosus, Systemic	* miR-199a-3p in CD4+ T cells plays a novel role in the pathogenesis of SLE and serves as a potential target for SLE.
lncRNA target	36763221	hsa-mir-769	Colorectal Neoplasms	CONCLUSION: Circ_0084188 upregulated the expression of KIF20A to promote the tumorigenesis of CRC through miR
lncRNA target	36762306	hsa-mir-493	Stomach Neoplasms	Furthermore, research into the underlying mechanisms of propofol's suppressive effects in GC cell proved that propofol therapy improved the degrees of expression of the potential tumor suppressor miR
lncRNA target	36762036	hsa-mir-505	Glioblastoma	All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505.
lncRNA target	36762032	hsa-mir-491	Pancreatic Carcinoma	Collectively, the findings from our study found a new potential strategy for gemcitabine resistance in PCa by illustrating the mechanistic insights of oncogenic ADSC-derived EVs-loaded NEAT1 via regulating the miR
circulation_biomarker_diagnosis_ns	36761245	hsa-mir-506	Osteoporosis, Postmenopausal	CONCLUSION: Our work suggested that circulating miR
circulation_biomarker_diagnosis_ns	36761245	hsa-mir-340	Osteoporosis, Postmenopausal	CONCLUSION: Our work suggested that circulating miR
other	36761165	hsa-mir-1321	Autism Spectrum Disorder	Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD.
other	36761165	hsa-mir-342	Autism Spectrum Disorder	Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD.
other	36760866	hsa-mir-26a	Carcinoma, Renal Cell	After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC.
other	36760866	hsa-mir-27b	Carcinoma, Renal Cell	After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC.
lncRNA target	36760811	hsa-mir-485	Osteoporosis	DISCUSSION: In conclusion, MALAT1 promoted osteogenic differentiation and inhibited cell apoptosis through the miR5p/WNT7B axis, which suggested that MALAT1 is a potential target to alleviate osteoporosis.
other	36760722	hsa-mir-16	Stomach Neoplasms	5p/HMGA1 axis to regulate the Tax resistance of GC cells.
other	36760720	hsa-mir-16	Stomach Neoplasms	PVT1/miR-16/CCND1 axis regulates gastric cancer progression.
lncRNA target	36760719	hsa-mir-153	Carcinoma, Non-Small-Cell Lung	3p sponge and regulated ITGB1 expression via adsorbing miR
lncRNA target	36760373	hsa-mir-135a	Hepatitis B, Chronic	CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway.
lncRNA target	36760373	hsa-mir-135a	Carcinoma, Hepatocellular	CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway.
genetics_overexpression_promote	36760249	hsa-mir-495	Bronchopulmonary Dysplasia	CONCLUSIONS: The aberrant overexpression of miR-495 may contribute to the development of BPD by targeting NEDD4L-ENaC pathway, implying an imbalance in lung fluid clearance.
other	36760244	hsa-mir-34c	Ovarian Neoplasms	We determined that LINC00665 is the most potential lncRNA upstream of ovarian cancer miRNA (hsa-miR-34c-5p)-P2RY14. Intervention of P2RY14 can affect the prognosis of ovarian cancer by affecting LINC00665-miR-34c-5p-P2RY14 axis.
other	36760243	hsa-mir-7	Carcinoma, Hepatocellular	miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
other	36759837	hsa-mir-375	Non-alcoholic Fatty Liver Disease	Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis.
other	36758875	hsa-mir-204	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-146a	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-1	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-16	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-124	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-206	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-132	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-26a	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
epigenetics	36758856	hsa-mir-29b	Pulmonary Disease, Chronic Obstructive	Collectively, these findings indicate that the miR-29b level in COPD controls Klotho methylation via DNMT3, which maybe a promising target for the treatment of COPD.
circRNA target	36758707	hsa-mir-139	Liver Cirrhosis	Mechanistically, circASPH directly targeted miR
lncRNA target	36758592	hsa-mir-124	Calcinosis	RESULTS: Compared with the blank group and no-load group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor group were increased (P<0.05). Compared with miR-124 inhibitor group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and the expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor combined with DAPT group were significantly decreased(P<0.05).
transcription factor target	36758470	hsa-mir-206	Abortion, Spontaneous	Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women.
transcription factor target	36758470	hsa-mir-18a	Abortion, Spontaneous	Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women.
circulation_biomarker_diagnosis_ns	36757626	hsa-mir-488	Esophageal Squamous Cell Carcinoma	circ_0024108 participated in the progress of ESCC through the miR-488-3p/USP14 axis. Circ_0024108 was differentially expressed in serum exosomes. Circ_0024108 might be a potential biomarker for the diagnosis of ESCC.
other	36757530	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Also, miRNA-34a was positively correlated with metabolic disorders associated with NAFLD such as hypertension and diabetes.
circulation_biomarker_diagnosis_up	36757530	hsa-mir-192	Non-alcoholic Fatty Liver Disease	Thus, larger cohorts are necessitated to certify the utility of serum MiRNA-34a and MiRNA-192 in monitoring the deterioration of NAFLD.
genetics_overexpression_suppress	36757298	hsa-mir-23b	Uterine Diseases	miR-23b-3p overexpression in infertile endometrial organoid-derived epithelial cells did not improve adhesion.
genetics_overexpression_promote	36756790	hsa-mir-21	Carcinoma, Renal Cell	Moreover, upregulation of PTEN, which is a target of miR-21, was observed in ccRCC cells with overexpression of GABPB1-IT1.
exosome	36756722	hsa-mir-128	Brain Ischemia	3p promotes OPC differentiation into OLs by suppressing BMP signaling, indicating that NSC-derived exosomal miR
genetics_knock down_promote	36756719	hsa-mir-542	Glioma	A battery of function experiments, including the CCK-8 viability test, colony formation assay, scratch migration assay, and Transwell invasion assay, was executed to address the responses of glioma cells to MTE treatment and gain or loss of function of lncMEG3, miR
genetics_knock down_promote	36756106	hsa-mir-19b	Leukemia, Myeloid, Acute	Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.
other	36756106	hsa-mir-17	Leukemia, Myeloid, Acute	We have investigated whether changes in the level of micro-ribonucleic acid (miR)-19b, miR-17, and miR-25, Wilms' tumor (WT1), and CCAAT enhancer-binding protein alpha (CEBPA) genes expression affect disease prognosis and clinical outcome in AML patients.
genetics_knock down_promote	36756106	hsa-mir-25	Leukemia, Myeloid, Acute	Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.
target gene	36755807	hsa-mir-502	Colorectal Neoplasms	FOXO1-Induced miR-502-3p Suppresses Colorectal Cancer Cell Growth through Targeting CDK6.
circulation_biomarker_prognosis_up	36755690	hsa-mir-135b	Carcinoma, Hepatocellular	RESULTS: Upregulation of miR-135b-5p was detected in patients with HCC with high serum AFP levels (AFP > 400 ng/ml).
genetics_GWAS	36755123	hsa-mir-4510	Breast Neoplasms	Two SNPs outside the miR-4510 binding site occurred, and Guanine (G) in both BC and NAT was changed into Thymine (T), as compared to the reference sequence (RefSeq).
lncRNA target	36754869	hsa-mir-20b	Cicatrix, Hypertrophic	Small nucleolar RNA host gene 1 (SNHG1) aced as a ceRNA to upregulate CTNNB1 expression via sponging miR-320b in HSFB.
genetics_knock down_promote	36754085	hsa-mir-1299	Triple Negative Breast Neoplasms	MiR-1299 interacted with the 3' untranslated region (3' UTR) of YY1, and YY1 overexpression partly reversed the effects of miR-1299 overexpression on BC progression.
transcription factor target	36753931	hsa-mir-1296	Placenta Accreta	Additionally, the dual-luciferase assay confirmed AGGF1 as a target gene of miR5p in placental tissues of PAS.
exosome	36753414	hsa-mir-218	Anxiety Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Mental Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Anxiety Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Neurotic Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-218	Mental Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-218	Neurotic Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
transcription factor target	36753399	hsa-mir-124	Mitochondrial Diseases	These results showed that under high-glucose and high-lipid conditions, the down-regulation of miR3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD.
transcription factor target	36753399	hsa-mir-124	dystonia 5	3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD.
genetics_GWAS	36752600	hsa-mir-27a	Osteitis Deformans	MIR27a exerts its effects on osteoclast differentiation through modulation of Squstm1/p62 whose mutations have been linked to Paget's disease of bone.
genetics_overexpression_promote	36752341	hsa-mir-1283	Her2-Positive Breast Cancer	The miR-1283 overexpression prevented the proliferation and enhanced apoptosis of HER2+ breast cancer cells, as well as inhibited tumor growth.
lncRNA target	36752339	hsa-mir-124	Depression	We speculated that autophagy was enhanced in the CUMS model of depression and might be mediated by miR-124 targeting Ezh2.
lncRNA target	36752331	hsa-mir-210	Severe Acute Respiratory Syndrome	3p was the single unique lung-specific miRNA, which was found to target the NSP3, NSP4, and NSP13 genes of SARS-CoV-2.
lncRNA target	36752150	hsa-mir-101	Nasopharyngeal Carcinoma	3p was decreased in cisplatin-resistant NPC cells and negatively targeted SOX2.
other	36751856	hsa-mir-4533	Celiac Disease	3p, the longer the diet adherence, the less the expression differed from controls.
other	36751856	hsa-mir-2681	Celiac Disease	3p, the longer the diet adherence, the less the expression differed from controls.
circulation_biomarker_diagnosis_up	36751747	hsa-mir-125a	Endometriosis	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-16	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
other	36751747	hsa-mir-99b	Carcinoma, Endometrioid	In ECO group, downregulated expression of miR-16 and miR-125a (P<0.05) was observed, whereas miR-99b, miR-143 and miR-145 were upregulated (P<0.05). miR-145 showed diagnostic power for ECO, and for endometrioid EC, miR-16, miR-99b, miR-125a and miR-145 showed diagnostic potential.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-145	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_up	36751747	hsa-mir-145	Endometriosis	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-125a	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
other	36751048	hsa-mir-646	Hypertension	Our findings illustrated the specific molecular mechanism of miR-3646 regulating hypertension.
exosome	36750776	hsa-mir-874	Kidney Diseases	CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage.
exosome	36750776	hsa-mir-874	Acute Kidney Injury	CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage.
exosome	36750722	hsa-mir-4536	Uterine Cervical Neoplasms	HKF-derived exosomes carried miR5p to CC cells and thereby inhibited PDHB-AS expression.
other	36750632	hsa-mir-1236	Ovarian Neoplasms	CONCLUSIONS: Our results provide evidence for the translational involvement of miR-1236 in the lymphangiogenesis of OC by regulating lymphangiogenesis-related factors and support the clinical importance of miR-1236 as a new diagnostic and prognostic biomarker for OC.
genetics_overexpression_promote	36750528	hsa-mir-155	Spinal Cord Injuries	5p overexpression promoted astrocyte activation and glial scarring in an SCI model.
lncRNA target	36750423	hsa-mir-181a	Diabetes Mellitus	Aim: The aim of this study is to investigate the mechanism and interaction of microRNA-181a (miR-181a), toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappaB) in gastric hypersensitivity in diabetic rats. (4) Intrathecal injection of miR-181a agomir down-regulated the expression of TLR4, reduced the hyper-excitability of gastric-specific neurons, and alleviated gastric hypersensitivity.
transcription factor target	36750173	hsa-mir-874	Breast Neoplasms	Through analysis, we found that miR
tissue_expression_up	36750001	hsa-mir-194	COVID-19	METHODS: In this study, T-box expressed in T cells (T-bet), GATA binding protein 3, The retinoid orphan receptor gamma t (RORgammat), forkhead box P3 (FOXP3), interleukin (IL)-17A, IL-8, and CC ligand 20 (CCL20) mRNA levels and, miR-155 and miR-194 levels were evaluated in 70 patients suffered from severe coronavirus disease 2019 (COVID-19) and 70 healthy subjects using Real-Time qPCR technique. MiR-194 may play crucial roles in regulation of RORgammat and IL-17A expression in healthy people, the phenomenon that is disrupted in the severe SARS-CoV-2 infected patients.
other	36749775	hsa-mir-22	Liver Neoplasms	Overall, our study revealed a novel miR3p/CBL/SPRY2/ERK axis that plays an important role in EMT, cell migration, and invasion of liver cancer cells.
genetics_knock down_promote	36749538	hsa-mir-326	Arthritis, Rheumatoid	Knockdown of lncRNA-EWSAT1 could upregulate miR-326 expression and attenuate its proliferation inhibition and apoptosis induction effect in RA-FLS.
circulation_biomarker_diagnosis_ns	36749234	hsa-mir-375	Esophageal Neoplasms	receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma.
genetics_GWAS	36749159	hsa-mir-451a	Polycythemia	3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis.
genetics_GWAS	36749159	hsa-mir-210	Polycythemia	3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis.
lncRNA target	36749091	hsa-mir-206	gastric adenocarcinoma	These findings provide new clues with prognostic and therapeutic implications in STAD and suggest that HOTAIR/miR-206/SOX9 might be a potential new strategy for therapeutic targeting of gastric cancer.
lncRNA target	36748746	hsa-mir-136	Fibrosis, Renal	CONCLUSION: Through in vitro and in vivo experiments, the present study was able to successfully prove that tacrolimus upregulates NORAD to compete with miR
lncRNA target	36748628	hsa-mir-9	Carcinoma, Hepatocellular	BGH3 axis.
genetics_overexpression_promote	36748323	hsa-mir-200a	Endometrial Neoplasms	RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression.
genetics_overexpression_promote	36748323	hsa-mir-15b	Endometrial Neoplasms	RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression.
other	36747515	hsa-mir-376a	Ovarian Neoplasms	CONCLUSION: This study uncovered a novel mechanism that MEG3 sponged miRNA-376a and YBX1 to regulate the expression of RASA1 and exert an effect on the angiogenesis of ovarian cancer.
lncRNA target	36747258	hsa-mir-657	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LINC00326/miR-657/DKK2 axis signaling blocked tumor-associated functions in NSCLC cells through the targeting Wnt/beta-catenin pathway.
other	36747073	hsa-mir-770	Vasoplegia	5p allowed the ability to distinguish between patients who could and could not develop VS, representing a potential predictive biomarker of VS.
circulation_biomarker_diagnosis_up	36747073	hsa-mir-548c	Vasoplegia	3p, and hsa-miR770-5p) were decreased in blood of VASO compared to NONVASO groups.
other	36746925	hsa-mir-4433b	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-4433b	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-4433b	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746221	hsa-mir-206	Intervertebral Disc Degeneration	The ceRNA network suggested that lnc-TMEM44-AS1-hsa-miRHDAC4 may be one crucial axis in IDD.
exosome	36746199	hsa-mir-21	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
exosome	36746199	hsa-mir-223	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
exosome	36746199	hsa-mir-146a	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
circulation_biomarker_diagnosis_down	36745296	hsa-mir-185	Abortion, Spontaneous	CONCLUSIONS: The current study, for the first time, successfully constructed the correlation between maternal circulating exosomal miR
genetics_knock down_promote	36745282	hsa-mir-96	Carcinoma, Hepatocellular	5p knockdown on hepatoma cell malignant behaviors.
genetics_GWAS	36745138	hsa-mir-221	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-22	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-146a	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-223	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-145	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-20b	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-1	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
lncRNA target	36744815	hsa-mir-10a	Uterine Cervical Neoplasms	This miR-10a-5p-mediated post-transcriptional regulation of UBE2I is involved in the tumorigenesis, invasion and migration of human cervical cancer.What are the implications of these findings for clinical practice and/or further research? These findings provide mechanistic insights into how miR-10a-5p regulates cervical cancer hyper-proliferation and metastasis, as well as a new target for clinical treatment.
transcription factor target	36744005	hsa-mir-25	Schizophrenia	3p is very likely to be associated with schizophrenia, revealing potential targets for the treatment and clinical diagnosis of schizophrenia.
lncRNA target	36743910	hsa-mir-124	Alzheimer Disease	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets.
lncRNA target	36743910	hsa-mir-103a	Alzheimer Disease	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets.
lncRNA target	36743910	hsa-mir-124	Diabetes Mellitus, Type 2	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir
lncRNA target	36743367	hsa-mir-204	Carcinoma, Non-Small-Cell Lung	The influence brought from gene LOC285758 knocking out could be reversed through suppressing miRNA-204, causing up-regulated CDK6 as well as LOC285758 expression in NSCLC tissues.
other	36743290	hsa-mir-376a-1	Autism Spectrum Disorder	Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients.
other	36743290	hsa-mir-376a	Autism Spectrum Disorder	Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients.
circulation_biomarker_diagnosis_down	36742232	hsa-mir-203a	Breast Neoplasms	In this study, the plasma levels of miR-129 and miR-203a were evaluated to investigate their diagnostic potential in breast cancer and its metastasis.
circulation_biomarker_diagnosis_ns	36742227	hsa-mir-21	Vitiligo	CONCLUSION: Peripheral blood of vitiligo patients-derived exosomal miR
genetics_knock down_promote	36742154	hsa-mir-34a	Spinal Cord Injuries	TERC knockdown facilitated the regeneration of neuron tissues yet inhibited inflammation in SCI through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis.
genetics_overexpression_suppress	36742139	hsa-mir-148a	Intervertebral Disc Degeneration	We aimed to investigate the effects of miR-148a-3p overexpression on IDD progression.
target gene	36741904	hsa-mir-150	Rhabdomyosarcoma	Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis.
other	36741376	hsa-mir-27a	Colonic Neoplasms	CONCLUSION: Our results indicated that CD55 is regulated by TFCP2, NF-kappaB, miR-27a-3p, and several immune-related genes, which in turn affects colon cancer.
lncRNA target	36741266	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	Conclusions: Our results suggest that Dvl1 is a potential therapeutic target for NSCLC and that miR-214 plays an inhibitory role in Dvl1-mediated activation of Wnt/beta-catenin signalling in NSCLC cells, which could affect NSCLC progression.
target gene	36741009	hsa-mir-106a	Ovarian Neoplasms	circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway.
target gene	36741009	hsa-mir-519d	Ovarian Neoplasms	circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway.
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-499	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-423	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-210	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
lncRNA target	36740760	hsa-mir-584	Carcinoma, Hepatocellular	3p inhibitor could reverse the effects of LINC00607 downregulation in HCC through rescue experiments.
transcription factor target	36740725	hsa-mir-223	Obesity	We infer that TBT induced miR-223 expression and increased adipogenesis in MSCs through the PPARgamma pathway and that transgenerationally increased expression of miR-223 plays an important role in the development of obesity caused by TBT exposure.
genetics_overexpression_promote	36740679	hsa-mir-140	Stomach Neoplasms	Overexpression of miR
other	36740569	hsa-mir-146a	Lupus Erythematosus, Systemic	Although we shed some light on the role of miR-146a in SLE, further study is recommended to improve our results.
exosome	36739582	hsa-mir-29b	Myocardial Infarction	To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI.
exosome	36739582	hsa-mir-29b	Cardiomyopathies	To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI.
transcription factor target	36739077	hsa-mir-128	Breast Neoplasms	Therefore, EMPA abrogates breast cancer stemness by inactivating SP1 and PKM2 via enhanced miR
other	36738648	hsa-mir-4732	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-939	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-142	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-23a	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
genetics_knock down_promote	36738516	hsa-mir-1238	Prostatic Neoplasms	Also, overexpression of SEPT2 abolished the suppressive impacts of miR
other	36738390	hsa-mir-10395	Stomach Neoplasms	3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance.
other	36738390	hsa-let-7g	Stomach Neoplasms	3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance.
lncRNA target	36738282	hsa-mir-1256	Esophageal Neoplasms	CircKRT1 acted as a sponge for miR-1256 in EC, and in-miR-1256 abolished the inhibitory effect of circKRT14 suppression on EC cell progression.
genetics_knock down_promote	36738165	hsa-mir-1278	Nasopharyngeal Carcinoma	Circ_0000285 knockdown-mediated anti-tumor effects in NPC cells could be largely reversed by silencing of miR-1278 or overexpression of FNDC3B.
genetics_overexpression_promote	36737832	hsa-mir-455	Squamous Cell Carcinoma of Head and Neck	5p overexpression and PDZK1IP1 inhibition promoted collective OSCC cell migration.
lncRNA target	36737782	hsa-mir-26b	Stomach Neoplasms	CONCLUSION: The newly identified miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop plays an important role in inflammation-related GC progression and may serve as a promising therapeutic target for GC.
lncRNA target	36737651	hsa-mir-92b	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737651	hsa-mir-92a	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737651	hsa-mir-320c	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737507	hsa-let-7c	Carcinoma, Hepatocellular	CONCLUSION: Let-7c-5p has been proved to suppress HCC by down-regulating immune-related CDCA8, which will help understand the pathogenesis of HCC and develop drugs for its treatment.
other	36737428	hsa-mir-1208	Breast Neoplasms	Mechanistically, TMEM105 regulated LDHA expression by sponging miR-1208, which further promoted cell glycolysis and BCLM.
circRNA target	36737402	hsa-mir-874	Esophageal Neoplasms	3p/ENAH axis, which might provide novel therapeutic targets for esophageal cancer intervention.
circulation_biomarker_diagnosis_ns	36736597	hsa-mir-200c	sporatic amyotrophic lateral sclerosis	RESULTS: Our results show a dysregulation of a signaling pathway involving ZEB1-AS1/hsa-miR-200c/beta-Catenin in peripheral blood mononuclear cells and in induced pluripotent stem cells-derived neural stem cells from sALS patients.
lncRNA target	36736544	hsa-mir-206	Anxiety Disorders	CONCLUSIONS: In conclusion, the key findings of the current study demonstrate that gut microbiota aggravated anxiety-like behaviors via the miR
other	36736231	hsa-mir-219	Cognition Disorders	This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro.
other	36736231	hsa-mir-219a	Cognition Disorders	This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro.
genetics_knock down_promote	36735765	hsa-mir-92a	Ovarian Neoplasms	MiR-92a not only promotes the proliferation, colony formation and paclitaxel resistance of SKOV3-Tax cells in OC, but also inhibits apoptosis, and it may be related to the regulation of the PTEN/Akt signaling pathway.
other	36735713	hsa-mir-199a	Heart Failure	The miR-199a NP downregulated levels of HSP, which had a certain protective effect against HF and had a high clinical-adoption and promotion value.
other	36735415	hsa-mir-370	Spinal Cord Injuries	circ_0013613 can promote the recovery of SCI by regulating miR3p/CASP1 to mediate neuronal pyroptosis.
tissue_expression_ns	36735043	hsa-mir-150	Pyruvate Kinase Deficiency of Red Cells	5p silencing also mitigated the impact of circVRK1 deficiency on OGD-evoked injury.
lncRNA target	36734950	hsa-mir-125b	Leukemia	miR-125b-5p inhibited leukemia cell proliferation and boosted apoptosis through decreasing MCL1.
transcription factor target	36734882	hsa-mir-181a	Fractures, Bone	These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures.
lncRNA target	36734882	hsa-mir-181a	Osteoporosis	These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures.
other	36734859	hsa-mir-411	Keloid	5p/JAG1 axis.
other	36734858	hsa-mir-873	Osteosarcoma	5p/ROCK1 axis in OS.
genetics_overexpression_suppress	36734856	hsa-mir-3175	Lung Neoplasms	Overexpressing miR-3175 or silencing SEMA6A could hamper the effects of LINC00312 on lung cancer cells. LINC00312 inhibits lung cancer occurrence and progression via the miR-3175/SEMA6A axis.
genetics_knock down_promote	36734855	hsa-mir-105	Carcinoma, Non-Small-Cell Lung	5p or knockdown of GIMAP6 reversed the inhibition of lncRNA EPB41L4A-AS1 overexpression on NSCLC cell proliferation.
genetics_overexpression_promote	36734854	hsa-mir-873	Uterine Cervical Neoplasms	Moreover, overexpression of LMCD1-AS1 promoted CC cell proliferation and EMT process through the regulation of miR
other	36734696	hsa-mir-760	Carcinoma, Hepatocellular	"The article ""LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma"", by Z.-C."
other	36734535	hsa-let-7b	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-21	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-92a	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-92a	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-19b	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-21	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-let-7b	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-19b	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
lncRNA target	36734386	hsa-mir-381	Reperfusion Injury, Cerebral Ischemia	CONCLUSIONS: The present research shows that LncRNA HCG11 silencing protects against cerebral ischemia/reperfusion injury through miR3p to regulate p53.
genetics_knock down_suppress	36734233	hsa-mir-210	Ischemic Stroke	TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits.
genetics_knock down_suppress	36734233	hsa-mir-210	Parkinson Disease	TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits.
lncRNA target	36734072	hsa-mir-671	Alzheimer Disease	Whether GABA can inhibit the reduction in CNTN1/2 expression by regulating CEBPalpha/circAPLP2/miR
other	36733403	hsa-mir-204	Diabetes Mellitus, Type 2	The regulation of TXNIP, miR-204, and MafA might play an important role in the mechanism of diabetes remission following bariatric surgery.
circulation_biomarker_diagnosis_up	36733250	hsa-mir-671	Pneumonia	5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstrual blood-derived stem cells on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury.
circulation_biomarker_diagnosis_ns	36733244	hsa-mir-92b	Pancreatitis	Further validation studies revealed that six miRNAs (miR-216a, miR-216b, miR-217, miR92b, miR-375 and miR-148a) were differentially expressed in the serum samples from patients with acute pancreatitis.
genetics_knock down_promote	36733207	hsa-mir-99a	Carcinoma, Hepatocellular	Finally, the experimental results of overexpression and knockdown confirmed that miRNA-99a-5p could inhibit cell proliferation in HCC, which also suggested that it may be an important tumor suppressor in HCC. CONCLUSION: MiRNA-99a-5p was negatively correlated with HCC progression and could act as a novel therapeutic target for HCC.
target gene	36732923	hsa-mir-361	Triple Negative Breast Neoplasms	LncRNA PRKCQ-AS1 regulates paclitaxel resistance in triple-negative breast cancer cells through miR-361-5p/PIK3C3 mediated autophagy.
other	36732514	hsa-mir-6125	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
other	36732514	hsa-mir-8069	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
other	36732514	hsa-mir-4505	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
target gene	36732504	hsa-mir-7	Colorectal Neoplasms	MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer.
lncRNA target	36732450	hsa-mir-125b	Lupus Erythematosus, Systemic	3p, miR-34a, miR-346, and miR-125b) in SLE PBMC cells was analyzed under proinflammatory cytokine IFNgamma treatment, and miR-125b was identified as the target miRNA.
lncRNA target	36732429	hsa-mir-218	Brain Ischemia	5p and up-regulated SMURF2, thus alleviating cerebral ischemic injury.
lncRNA target	36731227	hsa-mir-223	Diabetic Nephropathies	3p associated with IL6T mRNA and attenuated the progression of DKD by suppressing the downstream STAT3 activation, indicative of the implication of miR
genetics_knock down_promote	36730936	hsa-mir-195	Esophageal Squamous Cell Carcinoma	Finally, in vivo experiments were utilized to validate that knockdown of DGCR5 suppressed the Warburg effect via targeting of the miR-195/HK2 axis to increase the radiosensitivity of ESCC.
transcription factor target	36730721	hsa-mir-3	Non-alcoholic Fatty Liver Disease	Obtained results showed that resveratrol and atorvastatin combination therapy can improve nonalcoholic fatty liver disease by targeting genes involved in cholesterol metabolism and miR33.
genetics_knock down_suppress	36730637	hsa-mir-942	Ovarian Neoplasms	Circ-PIP5K1A knockdown reduced the resistance to DDP in OC via regulating miR
genetics_knock down_promote	36730555	hsa-mir-516b	Thyroid Neoplasms	Finally, we demonstrated that the miR-516b-5p inhibitor was capable of reversing ARAP1-AS1-knockdown's repressive effects on TC cell development by means of regulating PDE5A expression.
genetics_knock down_promote	36730544	hsa-mir-223	Carcinoma, Ovarian Epithelial	In addition, LARP4 knockdown increased the proliferation, migration, and invasion of EOC cells inhibited by miR
lncRNA target	36730426	hsa-mir-520d	Colorectal Neoplasms	PROX1-AS1 facilitated CRC progression and immune escape by targeting miR-520d. To sum up, this study affirmed that PROX1-AS1 could absorb miR-520d to upregulate PD-L1 in CRC, thereby promoting tumor progression and immune escape.
exosome	36730375	hsa-mir-1911	Adenocarcinoma of Lung	The present study demonstrated that M2 macrophage-derived exosomal miR
genetics_overexpression_promote	36730287	hsa-mir-498	Carcinoma, Hepatocellular	Moreover, ODC1 was a direct target of miR-498 and ODC1 overexpression abated the anticancer roles of miR-498 in HCC.
transcription factor target	36730262	hsa-mir-29a	Deltaretrovirus Infections	The objective of this study was to determine the relative expression of BLV-encoded miRNA blv-miR-b4-3p, the host analogous miRNA bo-miR-29a and a couple of potential target mRNAs (HBP-1 and PXDN, with anti-tumorigenic function in B-cells), in cattle naturally infected with BLV compared to uninfected animals (control group). Considering the similar expression of endogenous bo-miR-29a in both animal groups, the downregulation of PXDN in BLV-naturally infected cattle could be linked to blv-miR-b4-3p expression in these animals.
circRNA target	36729977	hsa-mir-377	Esophageal Neoplasms	Our study found that circ_0058063 could regulate the expression of HOXA1 by targeting miR
genetics_knock down_suppress	36729852	hsa-mir-508	Ovarian Neoplasms	3p overturned the effects of circSETDB1 knockdown on the Ptx resistance of ovarian cancer cells.
lncRNA target	36729201	hsa-mir-17	Wounds and Injuries	5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds.
lncRNA target	36729201	hsa-mir-17	Wounds, Nonpenetrating	CONCLUSIONS: Collectively, these results reveal a novel molecular mechanism that the autophagy pathway enhanced by Neat1/miR5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds.
other	36729102	hsa-mir-625	Uterine Cervical Neoplasms	Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1.
lncRNA target	36728962	hsa-mir-145	Carcinoma, Endometrioid	CONCLUSION: Circ_0005667 enhanced DDP resistance in EC by elevating IGF2BP1 through sponging miR
circulation_biomarker_prognosis_ns	36728308	hsa-mir-221	Thyroid Neoplasms	CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients.
circulation_biomarker_prognosis_ns	36728308	hsa-mir-146b	Thyroid Neoplasms	CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients.
other	36728308	hsa-mir-146b	Thyroid Diseases	The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification.
other	36728308	hsa-mir-221	Thyroid Diseases	The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification.
transcription factor target	36728287	hsa-mir-200b	Cholangiocarcinoma	CONCLUSION: L-Fucose inhibited the progression of CCA via the miR-200b/MAPK7 and signal transducer and activator of transcription 3 signaling pathways.
circRNA target	36728267	hsa-mir-92a	Pre-Eclampsia	The circRNA_06354/hsa-miR-92a-3p/VEGF-A axis might be a therapeutic target in the prevention and treatment of EOPE.
genetics_GWAS	36727832	hsa-mir-4736	Carcinoma, Pancreatic Ductal	Furthermore, blocking miR-4736 suppresses tumor growth in genetically engineered KPC (LSL-KrasG12D/+, LSL-Trp53R172H/+, and Pdx
circRNA target	36727737	hsa-mir-520h	Carcinoma, Non-Small-Cell Lung	MiR-520h restoration impaired gefitinib resistance and suppressed NSCLC cell proliferation, migration, and invasion by repressing YAP1.
other	36727735	hsa-mir-95	Cholangiocarcinoma	3p/TRAF3 axis and may become a novel approach for treating CHOL.
genetics_knock down_suppress	36727613	hsa-mir-509	Breast Neoplasms	CONCLUSION: Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR
other	36727428	hsa-mir-424	Nasopharyngeal Carcinoma	5p expression.
other	36727260	hsa-mir-29	Glioblastoma	miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42.
other	36727260	hsa-mir-29a	Glioblastoma	miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42.
genetics_overexpression_promote	36727232	hsa-mir-424	Carcinoma, Hepatocellular	5p mimic can reverse the role of overexpression of KIF23 in promoting the ability of HCC cells to proliferate, migrate and invade (P<0.05).
circulation_biomarker_diagnosis_up	36727070	hsa-mir-155	Carcinoma, Renal Cell	5p in serum was significantly upregulated in RCC patients, and miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-126	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-146a	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-21	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_up	36726727	hsa-mir-1287	Microscopic Polyangiitis	5p in the exosomes obtained from MPA plasma.
other	36726727	hsa-mir-1287	Endothelial Inflammatory Injury	CONCLUSION: Our study revealed that MPA-exo was involved in the intercellular transfer of miR5p and subsequently promote the development of acute endothelial injury in MPA.
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-744	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-155	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-93	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-93	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-495	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-451a	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-155	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-495	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-451a	Frailty	CONCLUSION: These results suggest that serum miR-451a should be investigated as a potential biomarker for frailty and show that the VIVIFRAIL multicomponent program modulates circulatory miRNAs expression, at least in older adults.
circRNA target	36726025	hsa-mir-1178	Myocardial Infarction	Together, our results reveal that circCEBPZOS attenuates detrimental post-MI remodeling via the miR3p/PDPK1 axis, which facilitates revascularization, ultimately improving the cardiac function.
other	36724751	hsa-mir-142	Mesothelioma	CONCLUSION: This study proposed that the miR3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.
circulation_biomarker_diagnosis_up	36724195	hsa-mir-26a	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-20a	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-142	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-485	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-20b	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
exosome	36723877	hsa-mir-20	Reperfusion Injury, Cerebral Ischemia	hUC-MSCs-Exos-derived circDLGAP4 reduced cerebrovascular injury by regulating miR-320/KLF5 signaling.
transcription factor target	36723677	hsa-mir-181a	Osteoporosis	The CTR, NFATC1, MMP-9, CTSK, and TRAP mRNA expression levels were substantially reduced during osteoclast differentiation and bone resorption in the Res treatment group.The results suggest that Res can reduce the RAW 264.7 cell differentiation into osteoclasts and relieve LPS-stimulated osteoporosis, and the underlying mechanism may be associated with the Res-inhibited activity of the TRAF6/TAK1 pathway through the increased miR-181a-5p expression.
other	36723462	hsa-mir-656	Hypertension	related dysfunction of endothelial cells in hypertension.
other	36723144	hsa-mir-18b	Alzheimer Disease	Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration.
other	36723144	hsa-mir-342	Alzheimer Disease	Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration.
transcription factor target	36723042	hsa-mir-146a	Vasculitis	In addition, we demonstrated that miR-146a encapsulated liposomes reduced vascular inflammation responses in HAECs and SMCs through inhibition of ICAM-1 expression and decreased monocyte adhesion. Thus, based on these results, miR-146a encapsulated liposomes may be promising for reducing vascular inflammation by targeting its multiple associated mediators.
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-208b	Acute Coronary Syndrome	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS.
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-143	Death, Sudden, Cardiac	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-208b	Death, Sudden, Cardiac	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-143	Acute Coronary Syndrome	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS.
tissue_expression_ns	36722721	hsa-mir-21	Breast Neoplasms	Moreover, MFS-CRISPR assay was evaluated by measuring clinical samples, and the difference of miR-21 expression of breast cancer patients and healthy donors was significant.
exosome	36722453	hsa-mir-374c	Carcinoma, Hepatocellular	MiR-374c-5p transferred by exosomes derived from bone marrow mesenchymal stem cell (BMSC) suppressed migration, invasion and proliferation of HCC cells.
genetics_overexpression_promote	36722424	hsa-mir-20a	Stomach Neoplasms	RUNX1-IT1 and miR-20a precursor were predicted to interact with each other, and overexpression of RUNX1-IT1 in GC cells decreased the expression levels of mature miR-20a.
genetics_knock down_promote	36722261	hsa-mir-183	Death	5p, whereas LINC00960 overexpression increases, but its knockdown decreases, the level of Nrdp1 and apoptosis.
lncRNA target	36722214	hsa-mir-493	Diabetic Nephropathies	In conclusion, TTN-AS1 exacerbated ECM accumulation via the miR3p/FOXP2 axis during DN development.
circulation_biomarker_prognosis_ns	36721512	hsa-mir-155	Chronic Gastritis	CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker.
circulation_biomarker_prognosis_ns	36721512	hsa-mir-155	Inflammation	CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker.
exosome	36720469	hsa-mir-378	Ovarian Neoplasms	Our study revealed a previously unknown regulatory pathway whereby CAFs-derived exosomes delivered circIFNGR2 and inhibited the malignant progression of OVCA by circIFNGR2/miR-378/ST5 axis.
genetics_knock down_suppress	36720318	hsa-mir-579	Hypoxia-Ischemia, Brain	CONCLUSION: This study demonstrated that circ_0007706 knockdown assuaged HIE-induced injury by decreasing TRAF6 expression via targeting miR3p.
other	36720158	hsa-mir-146a	Pediatric Cystic Fibrosis	Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling.
other	36720158	hsa-mir-25	Pediatric Cystic Fibrosis	Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling.
other	36719980	hsa-mir-370	Adenocarcinoma of Lung	High miR-370 expression was associated with poor overall survival (OS) among lung adenocarcinoma patients (p = 0.045).
genetics_knock down_promote	36719867	hsa-mir-148a	Leishmaniasis	Increased miR-148a in splenic leukocytes (SL) of dogs with CanL was observed in previous studies, and in silico analysis, identified possible pathways involved in immune response regulation that are affected by this miR.
transcription factor target	36719839	hsa-mir-186	Brain Injuries, Traumatic	5p, through upregulation IGF-1, attenuates the inflammatory factors, oxidative stress and by inhibiting NLRP3/ASC/caspase-1 signal pathway TBI in-vitro model.
other	36719832	hsa-mir-614	Alzheimer Disease	3p, etc.
other	36719832	hsa-mir-2115	Alzheimer Disease	3p, etc.
other	36719832	hsa-mir-193a	Alzheimer Disease	3p, etc.
genetics_overexpression_suppress	36719626	hsa-mir-543	Carcinoma, Non-Small-Cell Lung	TNRC6A was downregulated and miR-543 was overexpressed in NSCLC cells.
other	36719624	hsa-mir-211	Uterine Cervical Neoplasms	CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.
other	36718820	hsa-mir-326	Glioblastoma	In addition, miR-326 was downregulated in glioblastoma cells, which was verified to sponge circRNA-SMO and interact with CEP85. CircRNA-SMO sponges miR-326 to promote glioblastoma proliferation and migration by upregulating CEP85 expression.
genetics_overexpression_promote	36718644	hsa-mir-27a	Glioma	miR-27a-3p overexpression promotes hypoxia-challenged glioma cell aggressiveness, whereas FTO overexpression partially diminishes the oncogenic effects of miR-27a-3p overexpression.
circulation_biomarker_diagnosis_ns	36718306	hsa-mir-24	Lupus Erythematosus, Systemic	CONCLUSION: Our study provided an insight about the role of miR-24 and its target serum YKL-40 protein in the development of SLE-related inflammation and atherosclerosis.
lncRNA target	36717952	hsa-mir-1303	Osteoporosis	RESULTS: miR-1303 was lowly expressed, while cochlin (COCH) and KCNMA1-AS1 were highly expressed in the osteoporosis subjects. CONCLUSIONS: Our findings suggest that the KCNMA1-AS1/miR-1303/COCH axis is a promising biomarker and therapeutic target for osteoporosis.
other	36717793	hsa-mir-455	Intracranial Aneurysm	METHODS: Expression of the circular RNA circ-ATL1 and microRNA miR-455 was detected in IAs by RT-qPCR.
other	36717790	hsa-mir-125b	Asthma, Allergic	CONCLUSIONS: miR-125b-5p is significantly over-expressed in asthma, and AK089514-miR-125b-5p-TRAF6 axis play critical role in asthma by modulating macrophage polarization.
other	36717592	hsa-mir-149	Coronary Artery Disease	5p was verified in the stable CAD patients when compared to other groups.
other	36717592	hsa-mir-122	Coronary Artery Disease	5p was verified in the stable CAD patients when compared to other groups.
lncRNA target	36717528	hsa-mir-194	Squamous Cell Carcinoma of Head and Neck	5p and enhance its target gene (KLF7), thereby affecting OSCC development.
circulation_biomarker_diagnosis_down	36717388	hsa-mir-568	Heart Diseases	The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays.
circulation_biomarker_diagnosis_down	36717388	hsa-mir-568	Heart Failure	The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays.
lncRNA target	36717039	hsa-mir-133b	Breast Neoplasms	In addition, downregulation of NEAT1 decreased the migration and proliferation of BC cells by inhibiting the expression of CXCL12 by reducing the adsorption of miR-133b. Furthermore, inhibition of miR-133b reversed the interference of NEAT1 and CXCL12 in paclitaxel resistance, migration and proliferation of BC cells.
lncRNA target	36716981	hsa-mir-149	Osteoarthritis	CONCLUSION: Our study provides evidence that up-regulated miR-149 alleviates OA via inhibition of VCAM-1 and PI3K/AKT pathway, which is helpful for OA treatment.
circulation_biomarker_diagnosis_up	36716518	hsa-mir-146a	Rhinitis, Allergic	Serum exosome-derived miR-146a-3p seems to be a novel biomarker for predicting the short and long-term efficacies of SLIT in AR patients.
circRNA target	36715861	hsa-mir-186	Retinoblastoma	Circ_0119412 was found to be upregulated in RB, and could accelerate the progression of RB via the miR
other	36715854	hsa-mir-24	Leukemia, Myeloid, Acute	Taken together, this study emphasized the pro-oncogenic role of CEBPA-AS1 in AML and illustrated its connections with the upstream transcription factor ZFX and the downstream regulative axis miR3p/CTBP2, providing important insights to the cancerogenic process in AML.
epigenetics	36715362	hsa-mir-124-2	Uterine Cervical Neoplasms	OBJECTIVE: This study was undertaken to evaluate the performance of FAM19A4 and hsa-mir2 hypermethylation as a triage tool for women who are at risk of developing cervical cancer or high-grade cervical cancer precursor lesions by taking into consideration the cytology report, histology diagnosis, and human papillomavirus (HPV) status.
genetics_knock down_promote	36714464	hsa-mir-155	Diabetic Nephropathies	5p overexpression restored this.
target gene	36714373	hsa-mir-100	Uterine Cervical Neoplasms	Hypoxia-induced paclitaxel resistance in cervical cancer modulated by miR-100 targeting of USP15.
other	36714048	hsa-mir-146a	Asthma	We aimed to investigate the relationship between Treg, miR3p, and miR-146a-5p in relation to asthma phenotypes in search of novel biomarkers of disease severity.
other	36714048	hsa-mir-210	Asthma	3p is a sensitive biomarker and an independent risk factor for BA severity in Egyptian children.
circulation_biomarker_diagnosis_ns	36713778	hsa-mir-128	Parkinson Disease	Interestingly, a concomitant decreased expression of miR-128 was observed in the cellular models of PD. Thus, our study depicts the intracellular role of miR-128 in neuronal apoptosis and neurodegeneration and its implications as a biomarker being detectable in the circulating exosomes of PD patient blood.
other	36712879	hsa-mir-20	Heart Failure	The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction.
other	36712879	hsa-mir-204	Heart Failure	The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction.
other	36710985	hsa-mir-146a	Colorectal Neoplasms	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-215	Obesity	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-215	Colorectal Neoplasms	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-146a	Obesity	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
genetics_knock down_suppress	36709726	hsa-mir-128	Prostatic Neoplasms	GLIDR knockdown inhibited the invasion, EMT, and proliferation in PCa cells, and GLIDR was shown to sponge miR
exosome	36709645	hsa-mir-4655	Lung Neoplasms	Overall, our results indicated that exosomal miR5p secreted by lung cancer cells after irradiation promoted the proliferation and M2 polarization of macrophages.
other	36709365	hsa-mir-2008	Sjogren's Syndrome	Moreover, circ432 is validated to serve as the sponge of miR-2008, a differential expressed miRNA in SUS-diseased sea cucumbers, by Argonaute 2-RNA immunoprecipitation (AGO2-RIP) assay, luciferase reporter assay and RNA fluorescence in situ hybridization (FISH) in vitro.
other	36709121	hsa-mir-204	Carcinoma, Endometrioid	5p may play an important role in human endometrial cancer.
transcription factor target	36709037	hsa-mir-9a	Epilepsy	The bioinformatic assessment and disease enrichment analysis revealed that miR-9a-5p targets expressed with high confidence in the hippocampus are the most significantly associated with epilepsy.
other	36708978	hsa-mir-642b	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-760	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-424	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-21	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708662	hsa-mir-218	Child Development Disorders, Pervasive	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
other	36708662	hsa-mir-218	Heart Septal Defects, Atrial	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
other	36708662	hsa-mir-218	Mental Disorders	These results suggest an underlying mechanism of miR-218 involvement in neuropsychiatric disorders, and the interactions of layer-specific non-coding RNAs and proteins in regulating cortical development.
other	36708662	hsa-mir-218	Schizophrenia	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
circulation_biomarker_diagnosis_up	36708579	hsa-mir-373	Carcinoma, Hepatocellular	This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation. CONCLUSION: Circulating pre-TACE MiR-373 could assist as a noninvasive predictor marker of response to TACE bridging therapy in early HCC patients awaiting liver transplantation.
circulation_biomarker_diagnosis_up	36708579	hsa-mir-210	Carcinoma, Hepatocellular	This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation.
lncRNA target	36708573	hsa-mir-379	Endometrial Neoplasms	5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR
lncRNA target	36708560	hsa-mir-145	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
lncRNA target	36708560	hsa-mir-200	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
lncRNA target	36708560	hsa-mir-21	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
transcription factor target	36708044	hsa-mir-143	Glioma	In addition, the results indicated that miR3p, which might directly target the 3'UTR of the hexokinase 2 (HK2) gene to regulate its protein expression, was subsequently involved in L1CAM-mediated VM formation by glioma cells.
lncRNA target	36708020	hsa-mir-650	Colorectal Neoplasms	RT-qPCR or western blot assays were performed to verify DICER1-AS1, miR-650, and mitogen-activated protein kinase 1 (MAPK1) expression in CRC cells or tissues. CONCLUSION: Our investigations found that upregulation of DICER1-AS1 activates the MAPK/ERK signaling pathway by sponging miR-650 to promote CRC progression, revealing a possible clinically significant biomarker and therapeutic target.
other	36707813	hsa-mir-372	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
other	36707813	hsa-mir-373	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
other	36707813	hsa-mir-671	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
lncRNA target	36707017	hsa-mir-384	Brain Ischemia	Based on the above results, we speculated that the molecular mechanism of isoflurane post-conditioning to alleviate ischemic neuronal injury may be related to the regulation of miR5p/ATG5-mediated autophagy.
lncRNA target	36706943	hsa-mir-155	Arthritis, Rheumatoid	Further experiments showed that THY1 Ab downregulated the expression of JUNB by the hsa_circ_0094342/miRNA5P/SPI1 axis, inhibited RA angiogenesis and osteoclast differentiation, and relieved RA progression.
lncRNA target	36705783	hsa-let-7d	Hypertrophic Scar Fibrosis	Consistent with the results in vitro, the miR-let-7d mimics effectively ameliorated hypertrophic scar fibrosis in a rabbit ear hypertrophic scar model. Taken together, our results indicated for the first time that miR-let-7d attenuated hypertrophic scar fibrosis through modulation of iron metabolism by reducing iron uptake through DMT1, which may provide a novel therapeutic strategy for hypertrophic scar.
lncRNA target	36705739	hsa-mir-204	Uveal melanoma	As revealed by functional analysis, miR-204 suppressed UM cell invasion and migration.
exosome	36705422	hsa-mir-205	Chronic Periodontitis	This research is aimed to investigate the function of exosomal miR
other	36705420	hsa-mir-1207	Intervertebral Disc Degeneration	Quantitative real time PCR(qRT-PCR), enzyme-linked immunosorbent assay, and western blotting analyses were performed to evaluate the role of LINC01138, hsa-miR5p, and KIAA0101 during extracellular matrix (ECM) protein degeneration and cellular inflammatory response.
other	36705420	hsa-mir-1207	Osteoarthritis	5p is weakly expressed in OA tissues and cell models.
lncRNA target	36705418	hsa-mir-525	Venous Thrombosis	CONCLUSION: LINC00659 played an important role in DVT by regulating the apoptosis of vascular endothelial cells through regulating miR5p/Bax axis.
circulation_biomarker_diagnosis_ns	36705405	hsa-mir-495	Sepsis	RESULTS: In HUVECs stimulated with BS patient serum, NEAT1 expression was increased, while miR
lncRNA target	36705303	hsa-mir-574	Acute Lung Injury	This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6.
lncRNA target	36705303	hsa-mir-574	Sepsis	This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6.
genetics_overexpression_promote	36704943	hsa-mir-141	Pulmonary Fibrosis	3p and/or adenovirus vectors overexpressing Spred2 one week after BLM treatment.
other	36704851	hsa-mir-151a	Colorectal Neoplasms	Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR151a5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC.
transcription factor target	36704832	hsa-mir-155	Carcinoma, Hepatocellular	MiR-155 accelerates HCC cell proliferation, migration and invasion by targeting SHIP1 expression and inducing macrophage M2 polarization.
lncRNA target	36704357	hsa-mir-200a	Endometrial Neoplasms	The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
lncRNA target	36704357	hsa-mir-429	Endometrial Neoplasms	The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
circulation_biomarker_prognosis_up	36704329	hsa-mir-5	Migraine Disorders	The combination of serum levels of exosomal has-miR
circulation_biomarker_prognosis_up	36704329	hsa-mir-145	Migraine Disorders	The combination of serum levels of exosomal has-miR
other	36704329	hsa-mir-378a	Migraine Disorders	Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05).
circulation_biomarker_prognosis_up	36704329	hsa-mir-369	Migraine Disorders	The combination of serum levels of exosomal has-miR
other	36704329	hsa-mir-605	Migraine Disorders	Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05).
other	36703917	hsa-mir-497	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
other	36703917	hsa-mir-449b	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
other	36703917	hsa-mir-6087	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
genetics_overexpression_promote	36703756	hsa-mir-199b	Spinal Cord Injuries	Moreover, miR-199b-5p overexpression polarized M1 macrophage into M2 phenotype and promoted neural regeneration in SCI.
other	36703740	hsa-mir-9	Ovarian Neoplasms	Curcumin enhances the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis.
other	36703641	hsa-mir-567	Carotid Artery Diseases	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-4652	Carotid Artery Diseases	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-4652	Dementia, Vascular	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-567	Dementia, Vascular	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
genetics_knock down_suppress	36702852	hsa-mir-1275	Stomach Neoplasms	Overexpression and knockdown of miR-1275 in vitro could indirectly modulate the above lipid signalling by targeting FAAH, thereby affecting GC progression. Our study indicates that deregulated FAAH is a key lipid signal and the miR-1275/FAAH/AEA/LPA axis can serve as a diagnostic biomarker for GC or as a target for therapy development.
other	36702759	hsa-mir-501	Diabetes Mellitus, Type 2	Expression analysis of the PDGF-miR-501 signaling pathway could represent a powerful tool to classify patients in clinical trials that aim to improve muscle health and glucose homeostasis in diabetic patients.
other	36702354	hsa-mir-221	Inflammation	Previously, we found miR5p was aberrant and associated with the inflammation of RT induction.
transcription factor target	36701994	hsa-mir-34a	Esophageal Squamous Cell Carcinoma	RESULTS: LJZD significantly interfered with ILinduced activation of the miR-34a/STAT3/IL-6R feedback loop in ESCC by restoring the expression of the tumour suppressor miR-34a, and inhibited the proliferation of EC109 oesophageal cancer cells in a dose-dependant manner.
genetics_overexpression_promote	36701370	hsa-mir-130b	Leiomyosarcoma	Conversely, miR-130b-overexpressing LMS cells exhibited Rho-independent invasion, accompanied by down-regulation of Rho-pathway effectors.
genetics_knock down_suppress	36701095	hsa-mir-375	Breast Neoplasms	Knockdown of miR-375 expression in BC cells reduces cell proliferation, migration, and invasion by inverse correlation expression of HOXA5.
transcription factor target	36700779	hsa-mir-205	Atherosclerosis	CONCLUSION: ICA can alleviate AS and inhibit the proliferation and migration of HAVSMCs induced by ox-LDL, potentially mediated by the upregulation of miR5p.
circulation_biomarker_diagnosis_up	36700764	hsa-mir-193b	Elliptocytosis 2	High-throughput sequencing revealed that miR-193b-3p was markedly up-regulated in plasma exosomes of non-rejection LT patients.
genetics_knock down_promote	36700761	hsa-mir-141	Incontinentia Pigmenti	CONCLUSION: Circ_0044411 knockdown promoted cell viability and proliferation, inhibited inflammatory response and apoptosis by regulating miR3p/CCL16 axis, indicating that circ_0044411 might be a potential therapeutic target for IP.
lncRNA target	36700475	hsa-mir-361	Stomach Neoplasms	MUC13, which is targeted by miR
genetics_knock down_promote	36700300	hsa-mir-125a	Carcinoma, Hepatocellular	Overexpression of miR-125a-5p enhanced the repressive effects of CYTOR knockdown on HCC cells, and knockdown of HAX-1 enhanced the inhibitory effects of miR-125a-5p mimics on HCC cells.
lncRNA target	36700043	hsa-mir-10b	Glioma	The effect is mediated by the secreted miR-10b targets phosphoglycerate kinase 1 (PGK1) and insulin-like growth factor binding protein 2 (IGFBP2) that block cell-cycle progression and induce glioma cell death.
lncRNA target	36700022	hsa-mir-20a	Osteoarthritis	And then we analysed miRNA-320a-targeted OA genes via KEGG, GO enrichment and PPI Network.
lncRNA target	36699616	hsa-mir-361	Carcinoma, Hepatocellular	Mechanistically, BBOX1-AS1 enhanced the stability of PHF8 mRNA by targeting the PHF8 inhibitor miR
genetics_overexpression_promote	36699282	hsa-mir-1294	Esophageal Squamous Cell Carcinoma	PBX3 overexpression could reverse the suppressive roles of miR-1294 mimics on ESCC proliferation and invasion.
other	36698420	hsa-mir-194	Carcinoma, Hepatocellular	3p.
genetics_overexpression_promote	36698227	hsa-mir-128	Colonic Neoplasms	CONCLUSION: LncRNA PCAT1 was overexpressed in CC cells and facilitated CC cell proliferation and invasion via inhibition of miR
transcription factor target	36698180	hsa-mir-132	Diabetes Mellitus, Type 2	We identified Kruppel-like factor 7 (KLF7) as a target of miR
target gene	36697993	hsa-mir-103a	Lung Neoplasms	CYTOR Promotes Proliferation of Lung Cancer Cell by Targeting miR-103a-3p to Upregulate HMGB1.
other	36697494	hsa-mir-21	Infertility, Male	This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21.
other	36697494	hsa-mir-21	Infertility, Female	This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21.
circulation_biomarker_diagnosis_up	36697494	hsa-mir-21	Cataract, Congenital Zonular, with Sutural Opacities	MiR-21 abundance was higher in FF and CCs samples than in serum.
exosome	36697316	hsa-mir-92a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-21	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-200c	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-92b	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-24	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-423a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-222	Adenomyosis	3p and hsa-miR-423a-5p were associated with preeclampsia and miscarriage.
exosome	36697316	hsa-mir-26a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
lncRNA target	36697118	hsa-mir-944	Squamous Cell Carcinoma of Head and Neck	Furthermore, FUT8-AS1 enhanced the expression of transcription factor 4 (TCF4) via sponging miR-944 and recruiting fused in sarcoma (FUS), thus affecting OSCC cell biological behaviors via modulation on Wnt/beta-catenin signaling activity. To conclude, TCF4-mediated FUT8-AS1 could exacerbate OSCC cell malignant behaviors and facilitate tumor growth via modulation on miR-944/FUS/TCF4.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-221	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-4487	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-20	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-1908	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-99a	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-494	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
lncRNA target	36696967	hsa-mir-1228	Carcinoma, Non-Small-Cell Lung	Our findings elucidate the potential molecular mechanisms underlying the ability of SNH to suppress NSCLC growth through activation of pyroptosis via the TCONS-14036/miR5p/PRKCDBP pathway.
circulation_biomarker_diagnosis_up	36696711	hsa-mir-142	Rhinitis, Allergic	CONCLUSION: The expression levels of serum miR
circulation_biomarker_diagnosis_up	36696711	hsa-mir-155	Rhinitis, Allergic	CONCLUSION: The expression levels of serum miR
lncRNA target	36696241	hsa-mir-498	Colorectal Neoplasms	A study of the molecular mechanism suggests that a circ-FADS2/miR-498/S100A16/AKT signaling cascade may be a potential therapeutic target for the treatment of CRC.
genetics_knock down_suppress	36696015	hsa-mir-210	Myocardial Infarction	Knockdown of miR3p in N-EVs significantly impaired its ability to protect the heart after myocardial infarction.
genetics_overexpression_suppress	36695693	hsa-mir-449a	Aortic Valve Insufficiency	Overexpression of miR-449a not only inhibited the M1-polarization of macrophages in vitro but also improved the AR of transplant in vivo.
genetics_knock down_promote	36695641	hsa-mir-122	Triple Negative Breast Neoplasms	The expression of hub genes distinguished TNBC tumors with gain or loss of miR-122 from normal breast tissues.
transcription factor target	36695612	hsa-mir-20a	Iris Diseases	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
transcription factor target	36695612	hsa-mir-20a	Fibrosis	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
transcription factor target	36695612	hsa-mir-20a	Kidney Failure, Chronic	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
genetics_knock down_suppress	36695612	hsa-mir-20a	Kidney Diseases	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. Importantly, delivery of the miR-20a-5p mimic or inhibitor in the donor kidneys attenuated or aggravated renal loss and structural damage in cold storage transplantation injury.
other	36695578	hsa-mir-335	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
other	36695578	hsa-mir-27a	Hepatitis E	AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs.
other	36695578	hsa-mir-221	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
other	36695578	hsa-mir-122	Hepatitis E	AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs.
other	36695578	hsa-mir-194	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
exosome	36695327	hsa-mir-615	Diabetic Nephropathies	The combined diagnosis of urinary exosomal miRNA
other	36695179	hsa-mir-629	Azoospermia	5p (p = 0.03 and 0.06, respectively).
lncRNA target	36695093	hsa-mir-197	Carcinoma, Hepatocellular	3p/GNA14 (lncRNA/miRNA/mRNA) ceRNA axis to further explain the mechanism of sex-related prognosis in the development of HCC and to provide new insights into candidate biomarkers for targeted therapies.
circRNA target	36694911	hsa-mir-377	Carcinoma, Non-Small-Cell Lung	Furthermore, miR-377 inhibitor reversed the inhibitory ability of circ_0070659 silencing on malignant biological behavior of NSCLC cells. Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC.
lncRNA target	36694626	hsa-mir-766	Colorectal Neoplasms	Besides that, inhibition of miR-766 reduced CRC cell growth and sensitized cells to radiotherapy, and these effects mediated by miR-766 inhibitor were rescued by the silencing of SMAD4.
genetics_overexpression_promote	36694453	hsa-mir-326	Adenocarcinoma of Lung	Moreover, LINC01270 was found inhibiting miR-326 and thereby overexpressing the abundance of LARP1 to promote LUAD development via PI3K/AKT pathway. All of these findings demonstrate thatLINC01270 is a tumor promotor in LUAD via enhancing LARP1 expressed by sponging miR-326 to facilitate the development of LUAD.
transcription factor target	36694425	hsa-mir-34a	Osteomyelitis	EHP might be a potential adjuvant herbal remedy for the treatment of bone nonunion, and miRNA-34a-5p is a novel target for controlling bone and metabolic diseases.
other	36694220	hsa-mir-206	Thyroid Neoplasms	RESULTS: Compared with the patients with benign thyroid nodules, the expression level of miR-206 in fine-needle aspiration cytology of thyroid cancer patients decreased significantly and the expression level of CCND2 increased significantly. CONCLUSIONS: miR-206 and CCND2 may become new biomarkers for clinical diagnosis of thyroid cancer based on the fine-needle aspiration cytology of thyroid nodules.
lncRNA target	36693615	hsa-mir-448	Heart Failure	mediated upregulation in ischemia, suggesting a new mechanism for the antiarrhythmic effect of miR-448 inhibition.
lncRNA target	36693551	hsa-mir-155	Sepsis	In conclusion, our findings indicate that GAS5 suppresses inflammatory responses by modulating the miR5p/SIRT1/HMGB1 axis in sepsis, providing a novel therapeutic target for inflammation in sepsis.
circRNA target	36691537	hsa-mir-665	Triple Negative Breast Neoplasms	Collectively, the regulatory network circAR-E2E4-miRSTAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC.
other	36691432	hsa-mir-181a	Colorectal Neoplasms	Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6.
genetics_overexpression_suppress	36691322	hsa-mir-1287	Carcinoma, Non-Small-Cell Lung	5p interacted with RBBP4, and RBBP4 overexpression partly reversed the inhibitory effect of miR
other	36691005	hsa-mir-17	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-92a-1	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-18a	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-181a	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-155	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
transcription factor target	36690096	hsa-mir-221	Neurodevelopmental Disorders	Collectively, our data suggest fluoride impairs mitochondrial translation by dysregulating the miR3p/c-Fos/RMND1 axis to trigger mitochondrial dysfunction, leading to neuronal death and neurodevelopment defects.
other	36689923	hsa-mir-185	Asthma	3p/ZNFX1, may exist in asthma.
other	36689317	hsa-mir-375	Neuropathic Low Back Pain	We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP.
other	36689317	hsa-mir-455	Neuropathic Low Back Pain	We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP.
circRNA target	36689155	hsa-mir-146b	Intervertebral Disc Degeneration	Hsa_circ_0040039 may participate in IDD development by mediating the repair and regeneration of NPs through upregulation MMP2 and PCNA mediated by miR-146b-3p.
circulation_biomarker_diagnosis_up	36689014	hsa-mir-15a	Myocardial Infarction	This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression.
circulation_biomarker_diagnosis_up	36689014	hsa-mir-146a	Myocardial Infarction	This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression.
lncRNA target	36688989	hsa-mir-516b	Kidney Calculi	Patients with kidneys stones showed down-regulated LINC01197 and SIRT3 expression, and up-regulated miR-516b-5p expression. In conclusion, the present study revealed that lncRNA LINC01197 inhibited CaOx-induced kidney stones formation by regulating the miR-516b-5p/SIRT3/FOXO1 signaling pathway.
other	36688191	hsa-mir-155	COVID-19	CONCLUSION: The expression of miR-155 increased in patients with DLBCL and/or COVID-19.
other	36688110	hsa-mir-4647	Colorectal Neoplasms	miR-4647 is predicted in silico to bind to the MUC13 gene and was analyzed by RT-qPCR in 187 tumors and their adjacent non-malignant mucosa of patients with CRC.
lncRNA target	36686977	hsa-mir-582	Nasopharyngeal Carcinoma	In brief, the results of the research clarified circSMARCA5 modulated NPC cells' vital movement via the miR
transcription factor target	36686218	hsa-mir-372	Pre-Eclampsia	3p may act as a factor to cause PE and may also be a potential novel therapeutic target for PE.
circulation_biomarker_diagnosis_up	36685889	hsa-mir-628	Alzheimer Disease	We previously reported that plasma miR3p was up-regulated in AD with severe ACD, but not in severe AD without severe ACD or in our healthy controls.
other	36685889	hsa-mir-130a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-mir-27b	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-mir-151a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Keratoconjunctivitis Sicca	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685889	hsa-mir-146a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-let-7e	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-let-7a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . Conclusion: Hsa-let-7a-5p, which was significantly up-regulated in AD-ACD (+) and AD-ACD (-) , could positively regulate the important innate immune-related genes such as TLR3, RIG-I, and MDA5.
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Hypersensitivity	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685889	hsa-let-7d	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Dermatitis	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685833	hsa-mir-24	pancreatic adenocarcinoma	Correlation analysis suggested that the long non-coding RNA (lncRNA) AL049555.1 and the microRNA (miRNA) hsa-miR5p were involved in the expression of RNF169, composing a potential regulatory axis to control the progression of PAAD.
other	36685826	hsa-mir-214	Ischemic Stroke	"The functional enrichment of 282 DEGs between the two clusters was mainly concentrated in the ""regulation of apoptotic signaling pathway,"" ""cellular response to DNA damage stimulus,"" ""adaptive immune system,"" and ""pyroptosis."" The miRLTF-FOXJ1 axis may be a key regulatory pathway for IS."
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-122	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-192	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-100	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_down	36684655	hsa-mir-143	Diabetes, Gestational	3p levels are downregulated in the peripheral blood of patients with GDM.
other	36684425	hsa-mir-24	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
other	36684425	hsa-mir-23-2	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
other	36684425	hsa-mir-27a	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
exosome	36684253	hsa-mir-3120	Tuberculosis	Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis.
exosome	36684253	hsa-mir-3120	Adenocarcinoma of Lung	Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis.
other	36684045	hsa-mir-499	Carcinoma, Hepatocellular	CONCLUSION: In summary, this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals.
target gene	36684043	hsa-mir-590	Colorectal Neoplasms	Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis.
circulation_biomarker_diagnosis_ns	36683505	hsa-mir-637	Angelman Syndrome	RESULTS: The expression of circ_0033596 and GRB2 was significantly increased, while miR-637 was decreased in the blood of AS patients and ox-LDL-induced HUVECs compared with controls. CONCLUSION: Circ_0033596 depletion protected against ox-LDL-induced HUVEC injury by miR-637/GRB2 pathway, providing a therapeutic target for AS.
circRNA target	36683504	hsa-mir-1197	Angelman Syndrome	CONCLUSION: Circ_0090231 might protect against ox-LDL-mediated HUVEC injury via the miR-1197/RAB22A axis, which provides a therapeutic strategy for endothelial cell damage of AS.
other	36682830	hsa-mir-138	Osteoporosis	Thus, the miR5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis.
epigenetics	36682704	hsa-mir-188	Leukemia, Myeloid, Acute	5p promoter hydroxymethylation, and miR
circulation_biomarker_diagnosis_up	36682281	hsa-mir-130	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-21	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-146	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-182	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-1	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
other	36681676	hsa-mir-150	Cardiomyopathies	miR5p may be a predictor of sepsis severity development but warrants further study.
lncRNA target	36681521	hsa-mir-16	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
lncRNA target	36681521	hsa-mir-335	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
lncRNA target	36681521	hsa-mir-20a	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
other	36681070	hsa-mir-182	Triple Negative Breast Neoplasms	5p miRNAs were upregulated in LA (7.82 times, p &lt; 0.005; 6.12 times, p &lt; 0.005, respectively) and TN breast cancer samples (9.42 times, p &lt; 0.0001; 8.51 times, p &lt; 0.0001) compared to normal tissues.
other	36681070	hsa-mir-96	Triple Negative Breast Neoplasms	5p miRNAs were upregulated in LA (7.82 times, p &lt; 0.005; 6.12 times, p &lt; 0.005, respectively) and TN breast cancer samples (9.42 times, p &lt; 0.0001; 8.51 times, p &lt; 0.0001) compared to normal tissues.
genetics_knock down_promote	36680456	hsa-mir-1206	Lung Neoplasms	Moreover, inhibition of miR-1206 could suppress the malignant phenotypes of lung cancer cells, which was attenuated by KLF2 knockdown.
circulation_biomarker_diagnosis_ns	36680208	hsa-mir-141	Schizophrenia	3p, Wnt5a, and Arp2 might be potential clinical blood-based biomarkers or therapeutic targets for schizophrenia.
transcription factor target	36677874	hsa-mir-185	Nasopharyngeal Carcinoma	5p/STIM1 axis may serve as a potentially effective therapeutic target for the treatment of NPC.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-200a	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-141	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-21	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
other	36676955	hsa-mir-181c	Triple Negative Breast Neoplasms	Co-treatment of miR-181c-5p mimic and WA (at varying concentration) down-regulated cell cycle progression markers (CDK4 and Cyclin D1) at mRNA and protein levels.
other	36676927	hsa-mir-16	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
other	36676927	hsa-let-7c	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
other	36676927	hsa-mir-363	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
transcription factor target	36675268	hsa-mir-5591	Diabetes Mellitus	Moreover, the results confirm that the CMF treatment induced a reduction in the ROS production, an increase in the macrophage M2 anti-inflammatory phenotype through the activation of miRNA 5591, a reduction in inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6, an increase in anti-inflammatory ones, such as IL-10 and IL-12 and an increase in the markers related to improved wound healing such as collagen type I and integrins.
other	36675221	hsa-mir-20a	Leukemia, Lymphocytic, Chronic, B-Cell	In a multivariate analysis, high miR-20a expression remained an independent marker predicting long TTT (time to treatment) for CLL patients.
circulation_biomarker_diagnosis_ns	36675122	hsa-mir-221	Severe Asthma	The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR
circulation_biomarker_prognosis_up	36675028	hsa-mir-130a	Endothelial Dysfunction	Hence, serum miR-130a-5p could identify different stages of ED and independently predict CRTd response, therefore representing a novel prognostic HF biomarker.
other	36674994	hsa-mir-151a	Neurodevelopmental Disorders	This pilot study provides evidence that miR-151a-3p may aid the identification of infants at risk for neurodevelopmental delay.
circulation_biomarker_diagnosis_ns	36674813	hsa-mir-122	Non-alcoholic Fatty Liver Disease	miRNA-122, the most abundant liver-specific miRNA, protects hepatic steatosis and inhibits cholesterol and fatty acid synthesis in NAFLD. Previously, we have shown that compared with its expression in healthy controls, miRNA-122 decreased in the liver tissue but gradually increased in the serum of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, suggesting that miRNA-122 could have been transported to the serum.
lncRNA target	36674797	hsa-mir-200b	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
lncRNA target	36674797	hsa-mir-16	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
lncRNA target	36674797	hsa-let-7	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
other	36674758	hsa-mir-375	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-145	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-155	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-494	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-27	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-21	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
circulation_biomarker_diagnosis_ns	36674679	hsa-mir-24	Diabetes Mellitus, Type 2	Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR
circulation_biomarker_diagnosis_ns	36674679	hsa-mir-24	Diabetes, Gestational	Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR
other	36674633	hsa-mir-200c	Dyslipidemias	Finally, a phenotypic correlation performed in the CAD group revealed lower hsa-miR-200c-3p expression levels in CAD patients affected by dyslipidemia (+DLP, n = 58) (p &lt; 0.01).
epigenetics	36674633	hsa-mir-200c	Coronary Artery Disease	An integrated analysis of genome-wide DNA methylation and miRNA-seq results indicated a significant downregulation of hsa-miR-200c-3p (FCCAD = 2.97, p  0.05) associated to the hypermethylation of two sites (genomic coordinates: chr12:7073122-7073122 and chr12:7072599-7072599) located intragenic to the miR-200c/141 genomic locus (encoding hsa-miR-200c-3p) (p-value = 0.009) in CAD patients.
tissue_expression_ns	36674605	hsa-mir-146a	Brain Ischemia	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-146a	Parkinson Disease	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-155	Brain Ischemia	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-155	Parkinson Disease	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
transcription factor target	36674578	hsa-mir-143	Hyalinosis, Systemic	Furthermore, miR3p was preferentially expressed in SHFs and Itga6 was identified as one of targets.
other	36674578	hsa-mir-143	Motion Sickness	3p in cashmere growth.
other	36674462	hsa-mir-22	Respiratory Tract Infections	Regression analysis identified environmental (daycare attendance, atmospheric pollution, breastfeeding duration), microbial (Verrucomicrobia, Streptococcus phage), and host factors (miR5p) associated with URI frequency (p < 0.05).
lncRNA target	36672938	hsa-mir-204	Endomyocardial Fibrosis	By constructing regulatory networks, lincRNA-ZFP42-ACTC1, lincRNA-AMY2-STAT1, and/or lincRNA-AMY2/miR-204/STAT1 were sieved, and the results indicate that lncRNA could participate in IMF deposition through direct regulation or ceRNA.
lncRNA target	36672843	hsa-mir-126	Peripheral Arterial Disease	The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role of miRNA-126 and the vascular endothelium growth factor (VEGF) angiogenic pathways on this adaptation. WT promoted angiogenesis in the muscle affected by PAD, and miRNA-126 may have a role in this adaptation by inhibiting PI3KR2, enabling the progression of the VEGF signaling pathway.
circulation_biomarker_diagnosis_up	36672841	hsa-mir-34	Multiple Myeloma	We also observed that TP53 and MYC were negatively correlated with mature miR-34 expressions in the plasma cells of patients with MM.
other	36672804	hsa-mir-652	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-5484	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-4463	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-3945	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-920	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672782	hsa-mir-222	Hepatitis E	To our knowledge, it is the first time that miR3p has been described as a reference miRNA for use in CHEV sample analyses.
lncRNA target	36672150	hsa-mir-3916	primary biliary cholangitis 1	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
lncRNA target	36672150	hsa-mir-3916	Fibrosis	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
lncRNA target	36672150	hsa-mir-3916	Cholestasis	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
circulation_biomarker_diagnosis_ns	36672009	hsa-mir-15b	Autism Spectrum Disorder	Upregulated blood miR-15b-5p *expression may represent a useful diagnostic marker of ASD subjects, and it may regulate TGFBR3 mRNA expression.
other	36671979	hsa-mir-34a	Nervous System Diseases	Zip nucleic acid (ZNA)-based genomagnetic assay was developed herein for the electrochemical detection of microRNA-34a (miR-34a), which is related to neurological disorders and cancer.
other	36671979	hsa-mir-34a	Carcinoma, Hepatocellular	To show the applicability of the ZNA-based genomagnetic assay for miR-34a detection in real samples, a batch of experiments was carried out in this study by using the total RNA samples isolated from the human hepatocellular carcinoma cell line (HUH-7).
lncRNA target	36671913	hsa-mir-625	Colorectal Neoplasms	5p promoted cell proliferation and migration but inhibited apoptosis through phenotypic experiments; thus, we initially identified miR
genetics_GWAS	36671508	hsa-mir-146a	Osteoarthritis	Our genetic and transcriptomic data define a crucial role of miR-146a-5p in OA pathogenesis and implicate modulation of miR-146a-5p in articular chondrocytes as a potential therapeutic strategy to alleviate OA.
other	36671388	hsa-mir-675	Carcinoma, Hepatocellular	Oncofetal H19-derived miR-675 expression could be considered a potential noninvasive diagnostic and prognostic biomarker, outstanding the performance of the expression of tissue lncRNA-H19 for HCC.
epigenetics	36670548	hsa-mir-124	Esophageal Squamous Cell Carcinoma	MATERIALS AND METHODS: Promoter methylation of miR129-2, miR124-3 and ZNF569 was assessed, using quantitative methylation-specific PCR (qMSP), in tissue samples from normal esophagus, treatment-naive and post-ChRT ECa, as well as in liquid biopsies from ECa patients. DISCUSSION: MiR129-2(me) , miR124-3(me) and ZNF569(me) accurately discriminate ECa, either pre- or post-ChRT, from normal tissue, enabling ECa detection.
other	36670490	hsa-mir-145	Pneumonia, Mycoplasma	CONCLUSION: This study provided evidence that the up-regulated hsa_circ_0001326 in PE restrained trophoblast cells proliferation, migration, and invasion by sponging miR5p to elevate TGFB2 expression.
other	36670110	hsa-mir-511	Carcinoma, Hepatocellular	In addition, miR5p was expressed at a low level in HCC tissues, was negatively correlated HLTF, and regulated HLTF expression.
lncRNA target	36669583	hsa-mir-9	Carcinoma, Hepatocellular	Twist1-YY1-p300 phase-separated condensates were disrupted by metformin (Met) and thus reduce miR-9 expression, thereby inhibiting the malignant progression of HCC.
circulation_biomarker_diagnosis_ns	36662897	hsa-mir-221	Peripheral Nerve Injuries	Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
circulation_biomarker_diagnosis_ns	36662897	hsa-mir-221	Neuralgia	Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
circulation_biomarker_diagnosis_ns	36662424	hsa-mir-221	Ischemia	The revascularization of miR-221/222-transfeted ADSCs was further verified in a rat hind limb ischemia model. Furthermore, injection of miR-221/222 transfected ADSCs significantly improved rat hindlimb ischemia, as evidenced by increased blood flow and structural integrity and reduce inflammatory infiltration.
lncRNA target	36661031	hsa-mir-518a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: In vitro lncRNA HOXA11-AS silencing inhibited OSCC stem cell stemness by targeting the miR-518a-3p/PDK1 axis, thus enhancing OSCC cell radiosensitivity.
circulation_biomarker_diagnosis_up	36660723	hsa-mir-21	Lung Injury	3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS.
circulation_biomarker_diagnosis_up	36660723	hsa-mir-21	Shock, Hemorrhagic	3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS.
target gene	36660663	hsa-mir-202	Adenocarcinoma of Lung	MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.
exosome	36660623	hsa-mir-146a	Carcinoma, Non-Small-Cell Lung	Tumor cell-derived exosomal microRNA-146a promotes non-small cell lung cancer cell invasion and proliferation by inhibiting M1 macrophage polarization.
genetics_overexpression_suppress	36660616	hsa-mir-145	Syphilis	Additionally, overexpression of TLR4 reversed the protein expression associated with pyroptosis in M2 macrophage-derived exosome miR
other	36660602	hsa-mir-20a	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
other	36660602	hsa-mir-126	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
other	36660602	hsa-mir-26b	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
exosome	36660450	hsa-mir-210	Epilepsy	Exosomal miR-210 from MSCs attenuated neuronal inflammation and contributed to neurogenesis possibly by inhibiting microglial M1 polarization.
lncRNA target	36660176	hsa-mir-204	Myocardial Reperfusion Injury	5p/FBXW7 axis in myocardial IR injury, and DLX6-AS1 may be a potential target for the treatment of myocardial IR injury.
other	36660044	hsa-mir-10b	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-let-7a	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-mir-21	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-mir-181a	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-16	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-451a	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-423	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-185	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
genetics_knock down_promote	36659830	hsa-mir-1277	Endometrial Neoplasms	Besides that, MFGE8 overexpression also attenuated the inhibitory action of miR
lncRNA target	36658478	hsa-mir-1192	Spinal Cord Injuries	CONCLUSIONS: Our study clarified that the lncRNA TUG1/miR-1192/TLR3 axis is an important pathway for PBM to inhibit M1 macrophage polarization and inflammation, which provides theoretical support for its clinical application in patients with SCI.
lncRNA target	36658474	hsa-mir-142	Colitis, Ulcerative	5p was found to be highly expressed in UC, and its silencing inhibited LPS-stimulated Caco-2 cell apoptosis and inflammatory responses.
transcription factor target	36658407	hsa-mir-381	Leukemia, Myeloid, Acute	3p as the tumor suppressor within pediatric AML by targeting ROCK1.
genetics_overexpression_promote	36658310	hsa-mir-195	Adenocarcinoma of Lung	5p overexpression.
circulation_biomarker_diagnosis_ns	36657657	hsa-mir-195	Adenocarcinoma of Lung	5p expression in circulating exosomes of LAC patients was lower than that of healthy controls.
lncRNA target	36657426	hsa-mir-483	Colorectal Neoplasms	Conclusion The results suggested that BCAR4/miR3p/RAB5C axis has the potential to be explored as a novel therapeutic target for CRC treatment.
lncRNA target	36657061	hsa-mir-98	Ovarian Neoplasms	CONCLUSION: SNHG4 accelerates OC development via mediating the miR
other	36656656	hsa-mir-145	Plaque, Atherosclerotic	In vivo, this treatment reduced the atherosclerotic plaque area by 48.04% compared with treatment with free miR-145.
genetics_knock down_suppress	36656536	hsa-mir-93	Urinary Bladder Neoplasms	Knockdown miRNA
lncRNA target	36656498	hsa-mir-450b	Reperfusion Injury	This paper tested the hypothesis that Res could protect against cerebral ischemia-reperfusion injury (CI/RI) by modulating microglial polarization via the miR-450b-5p/KEAP1/Nrf2 pathway. Our study demonstrates that Res exerts neuroprotective effects on microglial M2 polarization through the miR-450b-5p/KEAP1/Nrf2 pathway during CI/RI.
circulation_biomarker_diagnosis_up	36656380	hsa-mir-133a	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circulation_biomarker_diagnosis_up	36656380	hsa-mir-637	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circulation_biomarker_diagnosis_up	36656380	hsa-mir-944	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circRNA target	36655489	hsa-mir-124	Fibrosis	Considering the important role of miR-124 in regulating liver fibrosis and HSCs activation, imatinib may exert its anti-fibrotic activity through miR-124.
other	36655275	hsa-mir-181a	Colonic Neoplasms	Collectively, LINC01232 enhances the proliferation, migration, invasion, and angiogenesis of COAD cells by decreasing miR-181a-5p expression.
genetics_overexpression_promote	36654514	hsa-mir-526b	Triple Negative Breast Neoplasms	Overexpression of miR-526b in TNBC cells decreased the expression levels of SLC16A1-AS1, while overexpression of SLC16A1-AS1 did not affect the expression of miR-526b.
lncRNA target	36653891	hsa-mir-28	Diabetes, Gestational	CONCLUSION: Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR
virus_miRNA	36653806	hcmv-mir-UL22A	Aortic Dissection	hcmv-miR-UL22A-5p high levels in the plasma of Aortic dissection patients
virus_miRNA	36653806	hcmv-mir-UL112	Aortic Dissection	hcmv-miR-UL112-5p high levels in the plasma of Aortic dissection patients
lncRNA target	36653745	hsa-mir-155	Retinal Diseases	CONCLUSIONS: Finally, our study identifies the lncRNA uc007nnj.1/miR5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death.
other	36653745	hsa-mir-155	Ischemia	DISCUSSION: Mechanistically, the results demonstrated that lncRNA uc007nnj.1 acts as ceRNA competitively binding miR5p, thereby enhancing the expression levels of Tle4, thus aggravating ischemia-related apoptosis in RGCs.
lncRNA target	36653745	hsa-mir-155	familial febrile seizures 1	5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death.
transcription factor target	36653507	hsa-mir-35	Breast Neoplasms	We studied the role of miR-335 and -145 on PD-L1 suppression in breast cancer. In summary, we found that miR-335 and -145 are novel tumor suppressors inactivated in BC, and these miRs may serve as potential therapeutic targets for breast cancer treatment.
exosome	36652132	hsa-mir-1827	Colorectal Neoplasms	These findings indicate hUC-MSCs-Exos as an inhibitor of M2 macrophage polarization and liver metastasis in CRC through inducing miR
lncRNA target	36651361	hsa-mir-140	Breast Neoplasms	5p suppressed tumor progression of breast carcinoma cells through inhibition of the AKT/STAT3/NF-kappaB pathway.
transcription factor target	36651333	hsa-mir-146a	Diabetes Mellitus	We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis.
transcription factor target	36651333	hsa-mir-146a	Cognition Disorders	We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis.
other	36651169	hsa-mir-188	Pre-Eclampsia	CONCLUSION: Our study demonstrated that circ_0001326 could promote trophoblast cell proliferation, invasion, migration and EMT in PE by miR3p/HTRA1 axis, indicating a novel insight into the pathogenesis of PE.
lncRNA target	36650622	hsa-mir-140	Lipodystrophy, Partial, Acquired	Inhibition of miR3p attenuated LRRC75A-AS1 deficiency-induced up-regulation of COL II, aggrecan and SOX9.
genetics_knock down_promote	36650344	hsa-mir-944	Tongue Neoplasms	We demonstrate that proliferation, migration, and invasion of tongue cancer cells are suppressed by MMP10 knockdown or miR-944 overexpression.
lncRNA target	36650131	hsa-mir-181a	Osteoporosis	Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis.
lncRNA target	36650131	hsa-mir-181c	Osteoporosis	Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-34a	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-206	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-128	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-21	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-136	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-512	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
other	36648863	hsa-mir-26b	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-22	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-16	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-21	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-21	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-126	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-26b	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-133a	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-25	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-17	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-186	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-126	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-92a	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-183	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-22	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-133a	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-92a	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-186	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-183	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-17	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-25	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-16	Colorectal Neoplasms	5p).
circulation_biomarker_diagnosis_ns	36648741	hsa-mir-21	Fibrosis, Renal	CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology.
circulation_biomarker_diagnosis_ns	36648741	hsa-mir-21	Glomerulonephritis, IGA	CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology.
exosome	36648415	hsa-mir-145	Myopia, Degenerative	5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration.
exosome	36648415	hsa-mir-143	Myopia, Degenerative	5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration.
other	36648259	hsa-mir-145	Breast Neoplasms	CONCLUSIONS: ICORG10/11 is the first Irish multicenter, translational research trial evaluating circulatory miRNAs as biomarkers predictive of long-term survival and correlated increased miR-145 expression with enhanced outcomes in early-stage breast cancer.
lncRNA target	36648213	hsa-mir-455	Depression	3p targets PSD-95 and co-regulates NR2B-PSD
lncRNA target	36647717	hsa-mir-194	Epilepsy, Temporal Lobe	Overall, our findings indicated that GA exerts protective effects on TLE young rats against neuronal injury by inhibiting ferroptosis through the miR
lncRNA target	36646789	hsa-mir-139	Pancreatic Carcinoma	Pancreatic cancer cells gain LPAR4 expression in response to stress by downregulating a tumour suppressor, miR5p.
circulation_biomarker_diagnosis_up	36646015	hsa-mir-133a	Myocardial Infarction, Acute	Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples.
circulation_biomarker_diagnosis_up	36646015	hsa-mir-208a	Myocardial Infarction, Acute	Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples.
lncRNA target	36646008	hsa-mir-223	Pneumonia	3p on its target NLRP3 was suppressed by circPWWP2A, which led to lung fibrosis.
transcription factor target	36645633	hsa-mir-193	Atherosclerosis	Thus, miR5p/SRSF10 may serve as a novel treatment target for atherosclerosis.
circRNA target	36645579	hsa-mir-205	Uterine Cervical Neoplasms	Circ_0000078 inhibits the growth of cancer by interfering with the miR5p/EREG network, acting as a tumor suppressor in CC.
other	36645554	hsa-mir-135b	Breast Neoplasms	mediated gene silencing involved in the ceRNA network of TNBC.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-215	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-527	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-190b	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
exosome	36644823	hsa-mir-29c	Ovarian Neoplasms	Among the miRNAs downregulated in CAF-Exo, miR-29c-3p in OC tissues was associated with metastasis and survival in patients. These results verify the significant contribution of exosomes from omental CAFs to OC peritoneal metastasis, which could be partially due to the relief of MMP2 expression inhibition mediated by low exosomal miR-29c-3p.
lncRNA target	36644819	hsa-mir-625	Nasopharyngeal Neoplasms	Our results suggest that the circLASP1/miR-625 axis is involved the therapeutic effects of MK-2206 on NPC by regulating autophagy, proliferation, and apoptosis through the AKT/mTOR pathway.
other	36644780	hsa-mir-1525	Influenza, Human	SARS-cov2 and influenza A virus regulation have been connected to ZFP36L1 from miRNA 1525 and ETV5 from miRNA 756, respectively.
other	36644193	hsa-mir-195	Carcinoma, Hepatocellular	The homo sapiens-microRNA-195 (hsa-miR-195) may have contributed to the upregulation of CHEK1 in HCC.
genetics_GWAS	36644163	hsa-mir-100	Biliary Atresia	METHODS: We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects.
exosome	36643863	hsa-mir-589	Stomach Neoplasms	CircSTAU2 could be wrapped in exosomes and delivered to recipient cells, and functioned as a sponge for miR-589 to relieve its inhibitory effect on CAPZA1, thus inhibiting GC progression. CONCLUSION: Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC.
other	36643677	hsa-mir-6833	Bronchopulmonary Dysplasia	CONCLUSIONS: This study identified 1 key upregulated lncRNA (i.e., MERGE.57185.1) in preterm neonatal BPD, and revealed the MERGE.57185.1/hsa-miR5p/EIF5A mechanism in preterm neonatal BPD from the lncRNA-miRNA-mRNA network.
exosome	36643646	hsa-let-7b	Lung Neoplasms	CONCLUSIONS: M1-Exos inhibit the proliferation, invasion, and metastasis of lung cancer cells through miRNA-let-7b-5p and GNG5 signaling pathways and inhibit the anti-apoptotic ability of lung cancer cells.
target gene	36643496	hsa-mir-34a	Ischemic Stroke	Gentamycin Rationally Repositioned to Inhibit miR-34a Ameliorates Oxidative Injury to PC12 Cells.
other	36643367	hsa-mir-196b	Stomach Neoplasms	TCGA data showed a high expression of miR-196b-3p in gastric cancer cases (P < .001).
circRNA target	36643258	hsa-mir-487a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Circ_0005050 acted as an oncogenic factor in OSCC progression through miR-487a-3p/CHSY1 axis.
genetics_knock down_suppress	36643221	hsa-mir-2278	Squamous Cell Carcinoma of Head and Neck	GNAS knockdown restored miR-2278 inhibitor-mediated effect in OSCC cells.
exosome	36642417	hsa-mir-9	Osteoarthritis	Intra-articular injection of exosomal miR
other	36642194	hsa-mir-132	Ovarian Neoplasms	These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway.
other	36642194	hsa-mir-195	Ovarian Neoplasms	These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway.
exosome	36642112	hsa-mir-211	Melanoma	We show that the highly metastatic melanoma tumor cells (POL) can transfer their metastatic competency to the low-metastatic melanoma tumor cells (OL) by exosomal miR5p.
transcription factor target	36641890	hsa-mir-155	Cognition Disorders	In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone.
transcription factor target	36641890	hsa-mir-34a	Cognition Disorders	In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone.
genetics_overexpression_promote	36641136	hsa-mir-196b	Glomerulonephritis, IGA	Inhibition of PTEN rescued the therapeutic effects of overexpression of FGD5-AS1 or inhibition of miR-196b-5p on IgAN.
circulation_biomarker_diagnosis_ns	36640912	hsa-mir-128	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Our results show that circulating miRs are potential biomarkers of ALL MRD, asmiR3p level both in PFP and EEF predicts day 15 FC MRD.
exosome	36640325	hsa-mir-27b	Atherosclerosis	Thus, obesity-induced exosomal miR-27b-3p promotes endothelial inflammation and facilitates atherogenesis by PPARalpha suppression.
circulation_biomarker_diagnosis_ns	36640195	hsa-mir-223	Acute Kidney Injury	3p and SNRK expression and high HDAC2 expression in peripheral blood.
other	36640056	hsa-mir-4717	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36640056	hsa-mir-138	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36640056	hsa-mir-28	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36639978	hsa-mir-590	Dermatitis, Atopic	Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis.
genetics_knock down_suppress	36639866	hsa-mir-181a	Colorectal Neoplasms	Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway.
other	36639835	hsa-mir-22	Tongue Neoplasms	We also detected activation of miR-22/lncRNA/KAT6B/NF-kappaB signalling in recurrent cancers compared to paired primary tongue cancers.
genetics_GWAS	36639674	hsa-mir-92a-1	Diabetic Nephropathies	5p epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN.
lncRNA target	36639265	hsa-mir-195	Breast Neoplasms	Breast cancer cell proliferation was regulated by the SNHG16/miR-195/PCMT1 axis. CONCLUSION: PCMT1 silencing inhibited cell proliferation and invasion and induced apoptosis in breast cancer cells and the SNHG16/miR-195/PCMT1 regulatory axis might serve as a potential therapeutic target for breast cancer.
other	36639145	hsa-mir-122	Liver Injury	We describe miR-122 concentrations in participants with antituberculosis drug-induced liver injury (AT-DILI). CONCLUSIONS: miR-122 concentrations in our participants with AT-DILI were considerably higher than previously reported in healthy volunteers and in patients on antituberculosis therapy without liver injury.
exosome	36638658	hsa-mir-99b	Neuralgia	Collectively, our findings demonstrated that MSC-EVs had an analgesic effect on neuropathic pain via promoting autophagy, and these antinociceptive effects were at least in part caused by MSC-EV-mediated transfer of miR-99b-3p, thereby inhibiting microglial activation and pro-inflammatory cytokines expression.
other	36637626	hsa-mir-17	Glioblastoma	5p, and Caspase 3 as apoptosis predictors in the GM patients.
other	36637626	hsa-mir-20	Glioblastoma	5p, and Caspase 3 as apoptosis predictors in the GM patients.
circRNA target	36637163	hsa-mir-135a	Carcinoma, Non-Small-Cell Lung	Taken together, circ-N4BP2L2 enhanced NSCLC progression via the miR-135a-5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC.
circulation_biomarker_diagnosis_up	36636641	hsa-mir-10527	Esophageal Squamous Cell Carcinoma	5p was found to be notably reduced in both the plasma exosomes and tumor tissues of ESCC patients with LNM, and plasma exosomal miR
exosome	36636640	hsa-mir-133a	Reperfusion Injury, Cerebral Ischemia	Furthermore, exosomal miR-133a-3p derived from BMSCs markedly alleviated the symptom of CI/R injury in vivo. CONCLUSION: Exosomal miR-133a-3p derived from BMSCs alleviates CI/R injury via targeting DAPK2/Akt signaling.
circulation_biomarker_prognosis_ns	36636634	hsa-mir-342	Lupus Erythematosus, Systemic	Meanwhile, the low expression level of serum miR
genetics_overexpression_promote	36636455	hsa-mir-653	Adenocarcinoma of Lung	5p to AGR2 and stepwise upregulated AGR2 overexpression in LUAD gefitinib resistant cells, resulting gefitinib resistance in LUAD.
lncRNA target	36636079	hsa-mir-6788	Stomach Neoplasms	GC therapy may be improved by conducting targeted studies of the CNALPTC1/miR
transcription factor target	36636078	hsa-mir-17	Colorectal Neoplasms	5p promoted CRC cell proliferation, metastasis, and invasion, while inhibiting apoptosis.
other	36636074	hsa-mir-125b-1	Colorectal Neoplasms	The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
other	36636074	hsa-mir-125a	Colorectal Neoplasms	The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
lncRNA target	36636064	hsa-mir-204	Stomach Neoplasms	NORAD also regulated KMT2D expression by targeting miR5p and mediated PTEN/PI3K/AKT signaling in GC.
lncRNA target	36636050	hsa-mir-767	Stomach Neoplasms	3p-CHD4 axis, which is associated with GC proliferation and carcinogenesis, and may represent a promising therapeutic target for the future cure of GC.
genetics_knock down_promote	36636045	hsa-mir-543	Pancreatic Carcinoma	MicroRNA-543 knockdown dramatically increased PC cell growth, invasion, metastasis, and EMT, as well as decreased apoptosis in functional studies.
other	36636042	hsa-mir-62	Colorectal Neoplasms	circ_0000799 promotes proliferation and invasion in CRC and EMT. These effects of circ_0000799 may be achieved by negatively regulating miR-62.
exosome	36635928	hsa-mir-125a	Nasopharyngeal Carcinoma	RESULTS: miR-125a-5p was highly expressed in NPC tissues and cells. CONCLUSIONS: GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis.
lncRNA target	36635757	hsa-mir-139	Glioblastoma	CONCLUSIONS: According to our research, circNDC80 is an oncogenic factor that promotes glioblastoma through the miR5p/ECE1 pathway.
circRNA target	36635458	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: CircZNF236 modulates OSCC via the miR
lncRNA target	36635290	hsa-mir-142	Carcinoma, Hepatocellular	3p by ST8SIA6-AS1 accelerated the growth of cells while preventing cell apoptosis in LIHC cells, and the inhibitory effect of miR
genetics_knock down_promote	36635223	hsa-mir-625	Carcinoma, Squamous Cell, Cutaneous	Circ_0001402 knockdown can suppress the development and chemoresistance of DDP-resistant CSCC cells at least partly through targeting miR
genetics_overexpression_suppress	36634743	hsa-mir-654	Craniosynostosis radial aplasia syndrome	The inhibition of NEAT1 overexpression on apoptosis and autophagy in OGCs was reversed by miR-654 mimics.
circRNA target	36633774	hsa-mir-339	Colorectal Neoplasms	3p inhibitor partly attenuated this effect.
target gene	36633773	hsa-mir-1304	Lung Neoplasms	Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p.
genetics_overexpression_suppress	36633140	hsa-mir-212	Metabolic Associated Fatty Liver  Disease 	Conversely, the overexpression of miR2123p abolished the ameliorative effects of exercise on MAFLD.
other	36632887	hsa-mir-21	Glioblastoma	INTRODUCTION: miRNA-21 (miR-21) is highly expressed in glioblastoma, facilitating tumor growth by blocking the expression of apoptosis-related genes. Therefore, an antisense microRNA oligonucleotide (AMO) against miR-21 was suggested as a therapeutic nucleic acid for glioblastoma.
other	36632615	hsa-mir-5088	Breast Neoplasms	Our previous study confirmed that miR5p was associated with malignancy and metastasis in breast cancer.
transcription factor target	36632614	hsa-mir-1290	Liver Cirrhosis	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1290	Liver Neoplasms	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Liver Neoplasms	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Liver Cirrhosis	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1290	Carcinoma, Hepatocellular	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Carcinoma, Hepatocellular	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
lncRNA target	36632453	hsa-mir-1303	Osteosarcoma	APLN increased PLOD2 expression in human osteosarcoma cell lines and cell migration via the mammalian Sterile 20-like kinase 1 (MST1), monopolar spindle-one-binder protein (MOB)1, and YAP cascades, and through hsa_circ_0000004 functioning as a sponge of miR-1303.
genetics_overexpression_promote	36631876	hsa-mir-193b	Pancreatic Carcinoma	miR-193b-3p and TRIM62 were overexpressed or silenced to examine their function in PC.
other	36631465	hsa-mir-33a	Melanoma	Last, a long non-coding (lncRNA) NEAT1/miR-33a-5p/IRS2 regulatory axis of the competing endogenous RNA network was built to investigate the mechanisms of SKCM metastasis progression. These findings highlight the regulatory axis of the lncRNA NEAT1/miR-33a-5p/IRS2, which may play a role in SKCM metastasis.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-200c	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-21	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-34a	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-22	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-143	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
genetics_GWAS	36631028	hsa-mir-449b	Abortion, Spontaneous	CONCLUSION: There is a significant association between the risk of RPL and miR-449b/TNF-alpha combination, and therefore, genetic analysis for specific combined genotypes can be an important screening method for RPL in Korean women.
other	36631017	hsa-mir-141	Nasopharyngeal Carcinoma	3p and vimentin in NPC tissues increased significantly.
exosome	36631008	hsa-mir-380	Pulmonary Disease, Chronic Obstructive	The expression of miR-380 was significantly elevated in exosomes derived from COPD alveolar macrophages. This process may be involved with abnormal expression of miR-380 in exosomes of COPD alveolar macrophages and down-regulation of CFTR in bronchial epithelial cells.
other	36630972	hsa-mir-99a	Familial Hypophosphatemic Rickets	MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients.
other	36630972	hsa-mir-99a	Norrie disease	The expression of miR-99a-5p was detected in patients with NDR, NPDR, and PDR. MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients.
lncRNA target	36630972	hsa-mir-99a	Duane Retraction Syndrome	In conclusion, MiR-99a-5p protected hRMECs against HG damage, and the miR-99a-5p might be a novel target for diagnosis of DR.
other	36629882	hsa-mir-7	Respiratory Distress Syndrome	5p in ARDS biopsies.
lncRNA target	36629518	hsa-mir-6742	Adenocarcinoma of Lung	RESULTS: Bioinformatics analysis and dual-luciferase identified FGF8 is the target-gene of miR
other	36629013	hsa-mir-136	Stomach Neoplasms	Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway.
genetics_overexpression_promote	36628810	hsa-mir-578	Breast Neoplasms	Additionally, miR-578 inhibitor or GINS4 overexpression could reverse the inhibitory effect of hsa_circ_0008673 silencing on BC cell progression. CONCLUSION: Hsa_circ_0008673 might promote BC progression via modulating miR-578/GINS4 pathway.
genetics_knock down_promote	36628645	hsa-mir-454	Stomach Neoplasms	Long Chain Non-Coding RNA (lncRNA) HOTAIR Knockdown Increases miR3p to Suppress Gastric Cancer Growth by Targeting STAT3/Cyclin D1.
lncRNA target	36628448	hsa-mir-16	Colonic Neoplasms	5p inhibition partly rescued the effects of CERS6-AS1 depletion on CC development.
target gene	36628219	hsa-mir-497	Carcinoma, Hepatocellular	Sanguinarine promotes apoptosis of hepatocellular carcinoma cells via regulating the miR-497-5p/CDK4 axis.
genetics_overexpression_promote	36628205	hsa-mir-29a	Carcinoma, Endometrioid	Overexpression of miR-29a-3p inhibited EC cell growth, migration, and invasion through the regulation of HDAC4, as it is a target of miR-29a-3p.
lncRNA target	36627684	hsa-mir-644a	Breast Neoplasms	Mechanistically, BCAR4 facilitates breast cancer migration and invasion via the miR-644a-CCR7 axis of the MAPK pathway. BCAR4 promotes ABCB1 expression indirectly by binding to and down-regulating miR-644a to induce chemo-resistance in breast cancer.
lncRNA target	36627670	hsa-mir-1275	Adenocarcinoma of Lung	It was transcriptionally repressed by DDP-activated PI3K/AKT/c-Myc signal in LUAD, promoting DDP-acquired chemotherapeutic resistance by regulating miR-1275 to suppress PROCA1/ZFP36L2-induced BCL2 degradation, which led to apoptotic signal reduction.
genetics_overexpression_promote	36627652	hsa-mir-335	Ovarian Neoplasms	RESULTS: Overexpression of FOXD3 impaired the proliferation and chemoresistance of OC cells, which was related to the promotion of the miR-335 expression.
exosome	36627634	hsa-mir-218	Colorectal Neoplasms	5p expression in cells and exosomes, inhibiting PTPRR expression, and ultimately activating the Ras/ERK/c-Fos signaling pathway.
genetics_overexpression_promote	36627571	hsa-mir-106a	Atherosclerosis	CONCLUSION: Overexpression of GASL1 might suppress ox-LDL-induced HUVEC cell viability, apoptosis, and inflammation by regulating miR-106a/LKB1 axis.
lncRNA target	36627545	hsa-mir-1296	Carcinoma, Hepatocellular	In conclusion, hsa_circ_0000519 promoted tumor progression and angiogenesis in HCC through the miR-1296/E2F7 axis.
other	36627081	hsa-mir-10a	Periapical Periodontitis	In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis.
other	36627081	hsa-mir-891a	Periapical Periodontitis	In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis.
genetics_knock down_promote	36627006	hsa-mir-143	Urinary Bladder Neoplasms	3p inhibition or MSI2 overexpression restored the malignant behaviors of BCa cells induced by circ_644 knockdown or RUNX3 overexpression.
transcription factor target	36626918	hsa-mir-32	Prostatic Neoplasms	CONCLUSION: These results indicate that the suppression of miR-32 might offer an auxiliary treatment procedure for addressing the invasion, progression, and metastasis in PCa patients by improving cell apoptosis.
other	36626488	hsa-mir-506	Osteosarcoma	Furthermore, immunohistochemistry and quantitative real-time PCR outcomes indicated that the expression level of SLC7A8 and hsa-miR-506 was differentially expressed in lung metastasis OS tissues and non-metastasis tissues.
lncRNA target	36626439	hsa-mir-137	Postoperative Cognitive Complications	Taking together, this experiment provide the first experimental and clinical evidence that LncRNA GAS5/miR-137 promoted anesthesia-induced cognitive function to increase inflammatory bodies in patients undergoing lumbar spinal canal decompression, suggesting it may be a biomarker of POCD and a potential therapeutic target for POCD.
genetics_GWAS	36626225	hsa-mir-3	Pulmonary Fibrosis	We demonstrate that specific genetic ablation of miR-33 in macrophages protects against bleomycin-induced pulmonary fibrosis.
circRNA target	36626032	hsa-mir-135a	Nasopharyngeal Carcinoma	Together, our study uncovered the tumor-initiating and pro-metastatic role of circMAN1A2-miR-135a-3p-UBR5-ATMIN axis in NPC regulation that may be a potential therapeutic target for human NPC.
circRNA target	36625877	hsa-mir-766	Intestinal Diseases	3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis.
genetics_knock down_suppress	36625260	hsa-mir-498	Colorectal Neoplasms	Since hsa_circ_0079480 knockdown inhibited CRC cells malignant behaviors through regulation of the miR-498/ATP5E axis, it can be concluded that hsa_circ_0079480 might have great potential as therapeutic target for CRC.
lncRNA target	36624948	hsa-mir-222	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624948	hsa-mir-221	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624948	hsa-mir-21	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624643	hsa-mir-19b	Irritable Bowel Syndrome	CONCLUSION: We report five novel microRNA-mRNA regulatory axes in IBS-D pathogenesis and speculated that PIK3R3, negatively regulated by hsa-miR-19b-3p, may regulate NF-kappaB production through the PI3K/Akt pathway, which accounts for the occurrence of clinical symptoms in IBS-D patients.
exosome	36624516	hsa-mir-141	Ovarian Neoplasms	CONCLUSIONS: This study uncovers miR-141 as an OvCa-derived exosomal microRNA mediating the tumor-stroma interactions and the formation of tumor-promoting stromal niche through activating YAP1/GROalpha/CXCRs signaling cascade, providing new insight into therapy for OvCa patients with peritoneal metastases.
genetics_overexpression_promote	36624091	hsa-mir-488	Stomach Neoplasms	Overexpression of circPOFUT1 enhanced autophagy-associated chemoresistance of GC cells in vivo, but it was inhibited by overexpression of miR
lncRNA target	36623778	hsa-mir-155	Irritable Bowel Syndrome	CONCLUSIONS: Decreased colonic COMT in PI-IBS-D patients drives abdominal pain phenotypes via the COMT/miR-155/TNF-alpha axis.
circulation_biomarker_prognosis_up	36623770	hsa-mir-98	Carcinoma, Hepatocellular	5p was significantly decreased, while HBEGF expression was significantly increased in the serum of HCC patients compared with the control group.
other	36623676	hsa-mir-125b	Aortic Aneurysm, Abdominal	In conclusion, AAA patients might be benefit from EVAR based on various pathways and some molecules, such as miR-125b and SATB1-AS1, related with shear stress.
exosome	36623674	hsa-mir-125a	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Exosomal miR-125a-3p is a potential predictor of response to anti-PD-1/PD-L1 therapy in advanced NSCLC patients with low PD-L1 expression.
genetics_overexpression_promote	36622742	hsa-mir-181a	Polycystic Ovary Syndrome	CDKN2B-AS1 is overexpressed in PCOS and may sponge miR-181a to promote granulosa cell proliferation.
transcription factor target	36622663	hsa-mir-361	Breast Neoplasms	Together, these studies identify miR3p inhibitor as a potential new treatment for drug-responsive and -resistant advanced BC.
other	36622069	hsa-mir-542	Mesenteric Ischemia	Exogenous S1P analogs administered in vivo protect murine intestinal barrier from damage due to mesenteric ischemia reperfusion, and damaged intestinal tissue had increased levels of miR5p.
target gene	36621840	hsa-mir-140	Breast Neoplasms	Doxorubicin resistance in breast cancer xenografts and cell lines can be counterweighted by microRNA-140-3p, through PD-L1 suppression.
lncRNA target	36621784	hsa-mir-155	Arthritis, Rheumatoid	Objective To investigate the expression regulation of autophagy-related genes(ATG)and the mechanism of autophagy in rheumatoid arthritis(RA).Methods The differentially expressed genes(DEG)of RA were identified from GSE55235 and GSE55457,on the basis of which the differentially expressed autophagy-related genes(DE-ATG)were selected from the Human Autophagy Database.STRING 11.0 and GeneMANIA were used to establish protein-protein interaction networks.Further,the transcription factor-gene-miRNA co-expression network was established via NetworkAnalyst and Cytoscape.Finally,receiver operating characteristic(ROC)curve and DrugBank were employed to evaluate the efficacy of the predicted biomarkers and the performance of drugs targeting DE-ATG.GraphPad Prism 8.2.1 and R 4.0.3 were used for statistical analysis and graphics.Results A total of 485 DEG were enriched in signaling pathways such as T cell activation,hormone regulation,osteoclast differentiation,RA,and chemokines.Eleven DE-ATG regulated the expression of RUNX1,TP53,SOX2,and hsa-mir5p in synovial tissues of RA patients and were involved in the response to environmental factors such as 2,3,7,8-tetrachlorodibenzodioxin and silicon dioxide.The ROC curve analysis identified the DE-ATG with good sensitivity and specificity,such as MYC,MAPK8,CDKN1A,and TNFSF10,which can be used to distinguish certain phenotypes and serve as novel biomarkers for RA.Conclusions In RA,down-regulated DE-ATG expression may promote apoptosis and lysis of chondrocytes.The identified novel biomarkers provides new ideas and methods for diagnosing and treating RA.The establishment of transcription factor-miRNA-gene co-expression network provides direct evidence for dissecting synovial inflammation and articular cartilage destruction.
target gene	36620931	hsa-mir-433	Colorectal Neoplasms	LncRNA IGFL2-AS1 as a ceRNA Promotes HCT116 Cell Malignant Proliferation via the miR-433-3p/PAK4 Axis.
other	36620850	hsa-mir-128a	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-149	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-145	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-181b	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
transcription factor target	36620589	hsa-mir-194	Gastrointestinal Neoplasms	Our finding highlights that miR-194 exerts a tumor-suppressive role in digestive system cancers by targeting ATP6V1F, PPP1R14B, BTF3L4 and SLC7A5.
target gene	36620570	hsa-mir-7705	Stomach Neoplasms	hsa_circ_0061276 may be a new biomarker for gastric cancer. The tumor suppressor role of hsa_circ_0061276 on gastric cancer likely occurs through a sponge effect on miRNAs such as hsa-miR-7705.
circulation_biomarker_diagnosis_up	36620222	hsa-mir-486	Cerebral Palsy	Interestingly, miR-486 was upregulated 2-fold in the EVs of CP vs. TD both at baseline and after exercise. Our data suggest that circulating miR-486 transported by EVs is elevated in individuals with CP and that miR-486 alters the transcriptome of myoblasts affecting both ECM- and sarcomerogenesis-related genes, providing a link to the skeletal muscle alterations observed in individuals with CP.
lncRNA target	36619898	hsa-mir-197	Lymphoma, B-Cell	5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-kappaB signaling pathway and might impact the apoptosis and signal transduction of DLBCL.
exosome	36619870	hsa-mir-191	Uveal melanoma	Additionally, the comparison of miRNA expression levels in exosomes derived from UM patients with those derived from healthy donors revealed that hsa-miR
lncRNA target	36619232	hsa-mir-122	Carcinoma, Hepatocellular	Rescue experiments showed that RPPH1 acted as a competing endogenous RNA (ceRNA) by sponging miR-122 in HCC cells. Our study demonstrates for the first time that RPPH1 promotes HCC progression via the miR-122/Wnt1/beta-catenin axis, which may represent a valuable therapeutic target for patients with HCC.
transcription factor target	36619199	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	The present study aimed to observe the effects of ECC-BYF III in a COPD rat model and dissect its potential mechanisms in regulating mucus hypersecretion via the miR-146a-5p/epidermal growth factor receptor (EGFR)/MEK/ERK pathway. The protective effect of ECC-BYF III in reducing airway mucus hypersecretion in COPD may involve the miR-146a-5p/EGFR/MEK/ERK pathway.
target gene	36618816	hsa-mir-363	Lymphoma, T-Cell	MiR-363 suppresses the tumor growth of natural killer/T-cell lymphoma via the SIRT6/PI3K/AKT axis.
lncRNA target	36618771	hsa-let-7a	Carcinoma, Hepatocellular	Chol-let-7a had some off-target effects, such as mild acute hepatitis-like inflammation and non-specific drug-induced kidney injury.
genetics_knock down_promote	36618768	hsa-mir-576	Thyroid Cancer, Papillary	5p was significantly overexpressed in PTC tissues and TPC-1 cells.
circulation_biomarker_diagnosis_ns	36618534	hsa-mir-15b	Obesity	Effects of Two Different School-Based Training on Serum miR15b Expression and BACKGROUND: Some circulating microRNAs, such as miR15b, are predictors of diseases associated with adulthood obesity. This study aimed to evaluate the effect of two selected school-based and high-intensity interval training (HIT) on miR15b expression and lipid profile of obese adolescents.
circulation_biomarker_diagnosis_ns	36618355	hsa-let-7i	Malaria	We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products.
circulation_biomarker_diagnosis_ns	36618355	hsa-mir-451a	Malaria	We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products.
other	36618264	hsa-mir-20	Hyperglycemia	In conclusion, in DM-induced cardiac injury, miR-320 and CD36 mutually enhance each other's expression, leading to a positive feedback loop and a sustained hyperlipidemic state in the heart.
other	36618263	hsa-mir-7	Brain Ischemia	Overall, our findings imply that CDR1as reconstitution is neuroprotective after stroke, probably by protecting miR-7 and preventing alpha-Syn-mediated neuronal death.
genetics_knock down_promote	36617978	hsa-mir-1205	Carcinoma, Hepatocellular	Furthermore, CSNK2B significantly promoted HCC cell proliferation, and CSNK2B overexpression or knockdown attenuated the effects of miR-1205 overexpression or inhibition on HCC cell viability, respectively.
other	36617839	hsa-mir-34a	Asthma	CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management.
other	36617839	hsa-mir-125b	Asthma	CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management.
lncRNA target	36617735	hsa-mir-513a	Urinary Bladder Neoplasms	Mechanistically, circHGS functions as a sponge of miR-513a-5p to elevate VEGFC expression and activate the AKT/mTOR signaling pathway, ultimately promoting BCa progression. Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa.
lncRNA target	36617513	hsa-mir-578	Breast Neoplasms	Circ_0048764 depletion suppressed the proliferative, migrative, and invasive abilities of BC cells, which was rescued by transfection of miR-578 inhibitors.
transcription factor target	36617469	hsa-mir-10b	Adenocarcinoma of Lung	RESULTS: The expression of miR-10b was up-regulated in non-small cell lung cancer, and miR-10b inhibitor could inhibit the proliferation of A549 cell.
other	36617199	hsa-mir-93	Endometriosis	CONCLUSION: VEGFA and MMP3 expression levels trended to be increased in both eutopic and ectopic endometrial tissues of endometriosis women, while down-regulation of miR-93 might be involved in the alteration of VEGFA and MMP3 in endometriosis.
target gene	36615779	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a.
circulation_biomarker_diagnosis_ns	36615122	hsa-mir-342	Breast Neoplasms	Furthermore, we examined three plasma miRNAs in BC patients (n = 108) and healthy subjects (n = 103) by RT-PCR, namely, hsa-miR
other	36615083	hsa-mir-200c	COVID-19	Here, we investigated miRNA-200c as a potential marker for the prediction of the severity of COVID-19 to preventively initiate and personalize therapeutic interventions in the future. Our study provides the basis for further evaluation of miRNA-200c as a predictive biomarker for the progress of COVID-19.
other	36614208	hsa-mir-15a	Memory Disorders	This study investigated the potential of Dex to mitigate MTX-induced neurotoxicity and memory impairment in rats and the possible role of the miR-15a/ROCK-1/ERK1/2/CREB/BDNF pathway.
lncRNA target	36614110	hsa-mir-200c	Esophageal Achalasia	Taking into account our previous results on the downexpression of miR-200c-3p in tissues of patients with achalasia correlated with an increased expression of PRKG1, SULF1, and SYDE1 genes, our aim was to explore the unknown biological interaction between these genes and human miR-200c-3p and if this relation could unravel their functional role in the etiology of achalasia. Our study provides, for the first time, functional evidence about the PRKG1 gene as a direct target and SULF1 and SYDE1 as potential indirect substrates of miR-200c-3p and suggests the involvement of NO/cGMP/PKG signaling in the pathogenesis of achalasia.
genetics_overexpression_suppress	36614061	hsa-mir-423	Prostatic Neoplasms	Pathway enrichment analysis revealed that stable overexpression of miR
circulation_biomarker_diagnosis_ns	36613908	hsa-mir-101	Ovarian Neoplasms	The relative levels of miR-24 and miR-101 in plasma exosomes of HFs were significantly higher than in plasma exosomes of OC patients, while the levels of these microRNAs in exosomes from plasma and ascites of ill females showed no difference.
other	36613808	hsa-mir-221	Breast Neoplasms	Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro.
other	36613808	hsa-mir-9	Breast Neoplasms	Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro.
genetics_GWAS	36613718	hsa-mir-155	Mycosis Fungoides	The purpose of this study is to evaluate the plasma levels of miR-146a and miR-155 in MF patients and to investigate their association with SNPs of their genes.
other	36613642	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-219a-2	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-199b	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-219a	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-9	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-124	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-129-2	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-223	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-4454	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-142	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
other	36613546	hsa-mir-500a	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-500a	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-206	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-206	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-548c	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-548c	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613525	hsa-mir-375	Non-alcoholic Fatty Liver Disease	Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis.
other	36613525	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis.
other	36612284	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	MiR-21 did not show any variation among groups; miR-27b was under-expressed in dysplastic lesions (p = 0.046); miR-181b was upregulated in high-grade dysplasia (p = 0.006), increasing with the degree of dysplasia, and decreasing in OSCCs.
other	36612284	hsa-mir-181b	Squamous Cell Carcinoma of Head and Neck	(4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia.
other	36612284	hsa-mir-27b	Squamous Cell Carcinoma of Head and Neck	(4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia.
circulation_biomarker_diagnosis_ns	36612201	hsa-let-7d	Carcinoma, Hepatocellular	In our Chinese cohorts, three serum-exosome-derived miRNAs (miR
circulation_biomarker_diagnosis_ns	36612201	hsa-mir-122	Carcinoma, Hepatocellular	In our Chinese cohorts, three serum-exosome-derived miRNAs (miR
lncRNA target	36612120	hsa-mir-545	Carcinoma, Renal Cell	Mechanistically, we found that circ-PRKCI promoted the proliferation of RCC via the miR3p/CCND1 signaling pathway.
genetics_knock down_promote	36611966	hsa-mir-21	Carcinoma, Renal Cell	5p inhibitor suppressed the cell growth and cell invasion of ACHN and OSRC-2 cells, which could be compensated by FDX1 knockdown, reinforcing the functional linkage between miR
transcription factor target	36611916	hsa-mir-21	proliferative diabetic retinopathy	This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR.
transcription factor target	36611916	hsa-mir-125	proliferative diabetic retinopathy	This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR.
other	36611869	hsa-mir-497	Parkinson Disease	5p in PD contributes to enhanced progressive neurodegeneration of PD patients.
genetics_overexpression_suppress	36611865	hsa-mir-7	Pancreatitis	The overexpressed SNHG11/miR
transcription factor target	36611425	hsa-mir-146a	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
transcription factor target	36611425	hsa-mir-155	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
transcription factor target	36611425	hsa-mir-221	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
circRNA target	36611218	hsa-mir-184	Osteosarcoma	5p/EGFR pathway, indicating that circEMB may serve as a therapeutic target for OSA.
other	36611161	hsa-mir-15b	Pulmonary Fibrosis	In addition, increased expression of miRNA15b was identified with decreased expression of Smurf2 mRNA in PF models.
other	36610331	hsa-mir-197	Osteoarthritis	RESULTS: OA tissues and model cells had higher abundance of circ_0003800 and SOX5, while miR3p content was lower.
transcription factor target	36610147	hsa-mir-195	Ovarian Neoplasms	CONCLUSION: Both in vitro and in vivo data demonstrated that TSN could reduce DDP resistance in OC through regulating the miR-195/ERK/beta-catenin pathway, highlighting the potential of TSN as an effective agent for favoring overcoming clinical DDP resistance in OC.
circulation_biomarker_diagnosis_ns	36609569	hsa-mir-6750	Nasopharyngeal Carcinoma	Here, we detected miR-6750, the precise molecular function of which was largely unknown, was significantly enriched in serum-SEVs from normal volunteers vs. patients with nasopharyngeal carcinoma (NPC).
circulation_biomarker_diagnosis_down	36609531	hsa-mir-339	Acute Kidney Injury	5p expression was downregulated in the blood of septic AKI patients, and miR
exosome	36609437	hsa-mir-598	Carcinoma, Non-Small-Cell Lung	In the present study, we sought to define the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-598 in NSCLC.
lncRNA target	36609391	hsa-mir-23b	Esophageal Neoplasms	Hsa_circ_0021727 promoted ESCC progression by activating TAB1/NFkappaB pathway by sponging miR-23b-5p. In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway.
lncRNA target	36609253	hsa-mir-141	Intervertebral Disc Degeneration	CONCLUSION: PLGA microspheres coloaded with TGF-beta1 and anti-miR-141 can reverse IDD by inhibiting the degeneration of NPCs.
other	36609154	hsa-mir-129	Memory Disorders	BACKGROUND: SAHA was reported to enhance the expression of miR5p, which was predicted to bind to 3' UTR of CASP-6, a gene playing crucial roles in the pathogenesis of memory impairment.
transcription factor target	36608839	hsa-mir-155	Hypoxia-Ischemia, Brain	Together, our results demonstrated that miR-155 exerted a negative effect in HIBD by targeting SIRT1, which could contribute to the treatment of neonatal patients with hypoxic-ischemic brain damage.
lncRNA target	36608833	hsa-mir-940	Ischemic Stroke	CONCLUSION: Depletion of circ_0006459 protected human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through miR-940/FOXJ2 pathway, providing a promising therapeutic target for ischemic stroke.
circRNA target	36608542	hsa-mir-384	Carcinoma, Renal Cell	miR-384 inhibitor transfection attenuated the inhibiting impacts of circ_0101692 silencing on ccRCC cell progression.
genetics_knock down_suppress	36608447	hsa-mir-373	Osteoarthritis	CONCLUSION: Our data confirmed that circ_0001721 knockdown alleviated IL-1beta-induced chondrocyte injury by miR3p/CXCR4 axis, which suggested that circ_0001721 might be a potential therapeutic target for OA.
genetics_overexpression_suppress	36607951	hsa-mir-154	Carcinoma, Pancreatic Ductal	In rescue assays, KPNA4 overexpression or miR
other	36607643	hsa-mir-872	Spinal Cord Ischemia	In conclusion, SCIRI in vivo and OGD/R in vitro stimulated the miR5p/FOXO3a/beta-catenin-TCF4 pathway, thereby promoting NSC proliferation.
lncRNA target	36607481	hsa-mir-195	Carcinoma, Hepatocellular	5p targeted CDK1 and repressed synthesis of new DNA in HCC cells, thus restraining HCC cell proliferation.
genetics_overexpression_promote	36607163	hsa-mir-612	Nasopharyngeal Carcinoma	overexpression-induced repression of the migration, adhesion, and proliferation of NPC cells via the activation of the PI3K/AKT pathway.
lncRNA target	36606668	hsa-mir-148a	Uterine Cervical Neoplasms	The Human papillomavirus E6 protein might reduce the expression of miR-148a-3p, relieve the inhibitory effect of miR-148a-3p on LIPG expression, and promote the progression of cervical cancer through the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B/mechanistic target of rapamycin kinase signalling pathway.IMPACT STATEMENTWhat is already known on this subject? LIPG provides lipid precursors, suggesting that it might function in the metabolism of carcinoma cellsWhat do the results of this study add? LIPG might be regulated by HPV16 E6/miR-148a-3p and promote cervical carcinoma progression via the PI3K/AKT/mTOR signalling pathway.What are the implications of these finding for clinical practice and/or further research? The results indicated that novel treatment and diagnosis strategies for cervical carcinoma could be developed related to LIPG.
other	36606643	hsa-let-7i	Ischemic Stroke	We selected five miRNAs (miR-17, miR-93, miR-450, miR-629, and let-7i) related to atherosclerosis based on a literature review. CONCLUSIONS: The expression level of let-7i was independently related to arterial stiffness in patients with cerebral infarction, suggesting that it plays a pathophysiological role in atherosclerosis.
lncRNA target	36606578	hsa-mir-145	Thyroid Cancer, Papillary	3p that targeted TGFBR2 and USP15, both of which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC.
other	36606461	hsa-mir-144	Obesity	Bivariate GWAS analysis found MIR144 gene and its related biological pathways may influence obesity and lipid levels.
circulation_biomarker_diagnosis_down	36606278	hsa-mir-29b	Sarcopenia	Moreover, we used real-time RT-PCR to measure the abundance of the CVRF-related miRNAs in the plasma of a cohort of 93 control and sarcopenia individuals, including miR-29b, miR-181a, and miR-494. We found that plasma miR-29b levels were significantly down-regulated in response to sarcopenia in the elderly with CVRF.
other	36606191	hsa-mir-143	Prostatic Neoplasms	miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer.
other	36605803	hsa-mir-146a	Diabetes Mellitus	Our previous studies have shown the ability of a cerium oxide nanoparticle (CNP) formulation conjugated with the anti-inflammatory microRNA miR146a (CNP-miR146a) to enhance the healing of diabetic wounds. Comparison with miR146a conjugated gold (bioactive, metal) and silica (bioinert, oxide) nanoparticles (AuNPs and SiO(2)NPs) was performed in the presence of H(2)O(2), as an analogue to the high levels of ROS present in the diabetic wound environment.
target gene	36605483	hsa-mir-22	Liver Neoplasms	Long noncoding RNA DSCR8 promotes the proliferation of liver cancer cells and inhibits apoptosis via the miR-22-3p/ARPC5 Axis.
genetics_knock down_promote	36605481	hsa-mir-653	Colorectal Neoplasms	Moreover, miR-653 served as carcinoma-promoting gene via targeting KLF6, and circSETD3 knockdown significantly reversed the inhibitory effect of KLF6 overexpression on CRC cells.
circulation_biomarker_diagnosis_ns	36604945	hsa-mir-181a	Osteoporosis	RESULTS: miR-181a-5p was highly expressed in the serum of osteoporosis patients.
lncRNA target	36604807	hsa-mir-486	Atrial Fibrillation	5p expression and had a potential targeting relationship with miR
lncRNA target	36604774	hsa-mir-3158	Migraine Disorders	5p via CNVs to modulate the mechanism of pain.
lncRNA target	36604774	hsa-mir-548e	Migraine Disorders	CNVs, the Cholinergic Receptor Nicotinic Alpha 7 Subunit (CHRNA7) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n = 120) aged 15-60 years, comparative, case-control study was conducted.
lncRNA target	36604721	hsa-mir-340	Osteosarcoma	CONCLUSION: FGF23 promotes osteosarcoma cell proliferation, migration and invasion by targeting miR5p gene expression.
circulation_biomarker_diagnosis_up	36604580	hsa-mir-484	Graves Ophthalmopathy	5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.
circulation_biomarker_diagnosis_up	36604580	hsa-mir-192	Graves Ophthalmopathy	5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.
target gene	36604405	hsa-mir-486	Thyroid Neoplasms	Circ_0124055 promotes the progression of thyroid cancer cells through the miR-486-3p/MTA1 axis.
lncRNA target	36604379	hsa-mir-8881	Charcot-Marie-Tooth disease type 1B	The aim of this study was to investigate the effects of lncRNA34977 on the proliferation, migration, invasion, and apoptosis of canine mammary tumor (CMT) cells through the regulation of miR-8881/ELAVL4 expression. Our study shows that lncRNA34977 promotes the proliferation, migration, and invasion and suppresses the apoptosis of CMT cells by regulating the expression of miR-8881/ELAVL4.
other	36603835	hsa-mir-223	Coronary Artery Disease	3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST.
transcription factor target	36603462	hsa-mir-342	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
transcription factor target	36603462	hsa-mir-150	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
transcription factor target	36603462	hsa-mir-142	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
other	36603443	hsa-mir-122	Breast Neoplasms	In the perusal, a novel electrochemical biosensor amplified with hierarchical flower-like gold, poly (n-butyl acrylate), and MXene (AuHFGNs/PnBA-MXene) nanocomposite and activated by highly special antisense ssDNA (single-stranded DNA) provide a promising alternative for miRNA-122 detection as a biomarker of breast cancer.
lncRNA target	36603340	hsa-mir-200c	Retinoblastoma	Our results demonstrate that miRNA-200c-3p inhibits EMT progression through the Wnt16/beta-catenin/ZEB1/E-cadherin axis, and the ZEB1 silencing response shows that miR-200c-3p regulates ZEB1-mediated EMT in retinoblastoma.
lncRNA target	36602696	hsa-mir-124	Stomach Neoplasms	HRCT1, negatively regulated by miR3p, may be a potential therapeutic target for patients with gastric cancer.
lncRNA target	36602629	hsa-mir-143	Diabetes Mellitus, Type 2	Collectively, lncRNA UCA1 inhibited mitochondrial dysfunction of skeletal muscle in T2DM by sequestering miR3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM.
lncRNA target	36602629	hsa-mir-143	Mitochondrial Diseases	3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM.
genetics_overexpression_promote	36602424	hsa-mir-25	Carcinoma, Non-Small-Cell Lung	Accordingly, overexpression of circ_BLNK improved DDP sensitivity of NSCLC cells via miR
lncRNA target	36602216	hsa-mir-122	Carcinoma, Hepatocellular	Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC.
lncRNA target	36602216	hsa-mir-122	Hepatitis C	Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC.
circulation_biomarker_diagnosis_up	36601739	hsa-mir-92a	Coronary Restenosis	The serum miR92a expression levels were significantly higher in patients with instent restenosis (ISR) compared with those in patients without ISR, whereas KLF4 expression was significantly reduced in the nonISR group.
lncRNA target	36601671	hsa-mir-130a	Inflammation	It was demonstrated that Pue induced the expression of miR-130a-5p, which suppressed the activity of HMGB2/NF-kappaB, contributing to the attenuation of infarct heart tissues.
other	36601516	hsa-mir-7	Endometrial Hyperplasia	CONCLUSION: We concluded that miR5p attenuates vascular smooth muscle cell migration and intimal hyperplasia after vascular injury by NF-kB signaling.
transcription factor target	36600989	hsa-mir-193b	Carcinoma, Hepatocellular	Enforced CDK1 expression attenuated miR-193b-3p-modulated suppressive actions on HCC cell proliferation and migration.
genetics_overexpression_promote	36600625	hsa-mir-375	Uterine Cervical Neoplasms	Besides, miR-375 was revealed to be a downstream target of circ_0002762, and miR-375 overexpression counteracted the promoting effects of circ_0002762 overexpression on CC cell viability and migration.
exosome	36600320	hsa-mir-124	Carcinoma, Non-Small-Cell Lung	3p significantly suppressed metastasis through extracellular exosome transport and intracellular PI3K/AKT signaling.
target gene	36599973	hsa-mir-206	Osteosarcoma	LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
target gene	36599932	hsa-mir-144	Liver Neoplasms	ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
genetics_overexpression_suppress	36599649	hsa-mir-139	Colonic Neoplasms	3p silencing or CDK16 overexpression abolished the inhibitory effects of baicalin on colon cancer proliferation.
circRNA target	36598961	hsa-mir-582	Leukemia, Myeloid, Acute	CONCLUSION: Our findings identify that suppression of circ_0003256 impedes the malignant behaviors of pediatric AML cells by regulating PRKACB expression by competing for shared miR3p.
other	36598779	hsa-mir-574	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
other	36598779	hsa-mir-133a	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
other	36598779	hsa-mir-27a	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
genetics_overexpression_promote	36598700	hsa-mir-342	Pre-Eclampsia	5p antagomir, and overexpressing PDCD4 (oe-PDCD4) vector into the placenta on the 16th day of pregnancy.
epigenetics	36598670	hsa-mir-129-2	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-1258	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-339	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-137	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-124-2	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	Significant differences in the level of methylation of MIR124-2 and MIR375 genes were revealed for smoking patients with squamous cell lung cancer.
genetics_knock down_promote	36598315	hsa-mir-568	Carcinoma, Hepatocellular	Also, circ_0097009 knockdown blocked tumor growth in vivoCONCLUSION: Together, this study indicated that the oncogenic function of circ_0097009 in HCC, and circ_0097009/miR-568/RNF38 axis was expected to be a novel therapeutic option for HCC patients (Tab.
lncRNA target	36598302	hsa-mir-146a	Myocardial Reperfusion Injury	METHODS: The expression levels of SOX2-OT and miR-146a-5p in OGD/R-treated H9C2 cells and in myocardial tissues of MIRI rats were measured by qRT-PCR. CONCLUSIONS: Silencing of SOX2-OT relieved the apoptosis, inflammation, and oxidative stress of myocardial cells via up-regulating miR-146a-5p, contributing to the remission of MIRI (Fig.
transcription factor target	36598122	hsa-mir-155	Bone Diseases	Thus, Mir155 showed a catabolic effect on osteogenesis and bone mass phenotype via interaction with the S1pr1 gene, suggesting inhibition of Mir155 as a potential strategy for bone regeneration and bone defect healing.
genetics_knock down_suppress	36597907	hsa-mir-181a	Ovarian Neoplasms	In this study, the CCMV VLP was applied to encapsulate two different formats of anti-miR-181a oligonucleotides: naked RNA and chemically stabilized RNA to knockdown highly regulated miR-181a in ovarian cancer cells.
other	36597862	hsa-mir-335	Osteosarcoma	METHODS: In the current work, the expression of circUSP48, miR-335 and SNIP1 in OS cell lines and tissues were evaluated using qRT-PCR. Importantly, circUSP48 promoted OS malignancy by sponging miR-335 to upregulate SNIP1.
other	36597856	hsa-mir-498	Stomach Neoplasms	Moreover, hsa_circ_0001944 sponged miR-498 to increase GSPT1 expression, thereby promoted excessive proliferation and maintained the malignant phenotype of GC cells. CONCLUSION: The present study demonstrates the hsa_circ_0001944/miR-498/GSPT1 axis contributes to GC development.
circRNA target	36597773	hsa-mir-370	Acute Kidney Injury	Conclusion: Our data demonstrated that circ_0114428 contributed to septic AKI progression by regulating miR3p-mediated TIMP2 expression, which provided a promising target for septic AKI treatment.
other	36597599	hsa-mir-223	Sjogren's Syndrome	MiR3p increased while ITPR3 decreased in samples from SS patients and INF-gamma-induced SGECs.
circulation_biomarker_diagnosis_ns	36597468	hsa-mir-143	Diabetes Mellitus, Type 2	CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention.
circulation_biomarker_diagnosis_ns	36597468	hsa-mir-145	Diabetes Mellitus, Type 2	CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention.
genetics_overexpression_promote	36597176	hsa-mir-34	Hepatitis B, Chronic	Overexpression of pHBV(1.3) further confirmed that HBV downregulates miR-34 expression.
genetics_overexpression_suppress	36597175	hsa-mir-138	Carcinoma, Non-Small-Cell Lung	Moreover, overexpression of SNIP1 rescues the miR
other	36596777	hsa-mir-29a	Leukemia, Promyelocytic, Acute	APA exerts this effect by shortening the 3'UTRs of the Col1a1 and Col1a2 mRNAs, thus removing the binding sites of miR-29a-3p, which would otherwise strongly promote the degradation of both transcripts.
genetics_overexpression_suppress	36596504	hsa-mir-137	Spinal Cord Injuries	overexpressing BMMSC exosomes may serve as a treatment option for SCI recovery.
circulation_biomarker_diagnosis_ns	36596338	hsa-mir-548n	Aortic Aneurysm, Abdominal	CONCLUSION: Serum let-7b-5p and miR548n significantly improved the ability to diagnose AAA.
other	36596006	hsa-mir-149	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-196a-2	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-499	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-146a	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
target gene	36595346	hsa-mir-455	Pancreatic Neoplasms	IL-6 Accelerates the Proliferation and Metastasis of Pancreatic Cancer Cells via the miR-455-5p/IGF-1R Axis.
exosome	36595161	hsa-mir-138	Alzheimer Disease	In the present study, both in vitro and vivo experiments were employed, and we found Catalpol (Ca), the main extract of Rehmannia, could mitigate AD progression both in vitro and in vivo by promoting miR5p level in neural stem cell secreted exosomes.
circulation_biomarker_diagnosis_ns	36594832	hsa-mir-21	Stroke	The increase in miR-21a-5p secretion may have biomarker potential, as high blood levels of miR5p in stroke patients were associated with significant disability at hospital discharge.
lncRNA target	36594718	hsa-mir-139	Carcinoma, Hepatocellular	CONCLUSION: Matrine inhibited HCC cell malignancy through the circ_0013290/miR
circulation_biomarker_prognosis_down	36594100	hsa-mir-1275	Breast Neoplasms	We found that miR-1275 was significantly downregulated in plasma from patients resistant to chemotherapy and in chemoresistant BC cell lines, while patients with low levels of miR-1275 showed poor overall survival.
genetics_overexpression_promote	36594050	hsa-mir-15a	Carcinoma, Hepatocellular	Moreover, miR-15a-5p overexpression reversed the hsa_circ_0006988-mediated SOR-R and enhanced IGF1 levels in HCC cells.
other	36593966	hsa-mir-217	Periodontitis, Diabetic	Finally, antagomiR-217, a miRNA antagonism, was delivered into the periodontium to treat LIP-induced diabetic periodontitis.
genetics_overexpression_promote	36593867	hsa-mir-1258	Carcinoma, Non-Small-Cell Lung	miR-1258 overexpression weakened the effect of circ_0000520 overexpression on NSCLC cells.
other	36593510	hsa-mir-146a	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593510	hsa-mir-133b	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593510	hsa-mir-16	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593385	hsa-mir-31	Uterine Cervical Neoplasms	LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p.
transcription factor target	36593242	hsa-mir-149	Colorectal Neoplasms	In conclusion, our findings not only highlight the significance of DDX17 in the aggressive development and prognosis of CRC patients, but also reveal a novel mechanism underlying DDX17-mediated CRC cell metastasis and EMT progression through manipulation of the miR
genetics_GWAS	36593103	hsa-mir-223	Carcinoma, Hepatocellular	RESULTS: Genetic deletion of miR-223 markedly exacerbated tumourigenesis in inflammation-associated HCC.
lncRNA target	36592647	hsa-mir-582	Inflammation	5p attenuated the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 through suppressing the degradation of the NF-kappaB inhibitor alpha, followed by the nuclear translocation of NF-kappaB.
lncRNA target	36592647	hsa-mir-582	Immune System Diseases	Therefore, exogenously applied miR5p can attenuate the NF-kappaB signaling pathway via targeting Skp1; this provides a prospective therapeutic strategy for treating inflammatory and immune diseases.
circRNA target	36592530	hsa-mir-125b	psoriasis 1	Herein our findings showed increased expression of circVAPA and Sirt6 and decreased level of miR-125b-5p in psoriatic lesional tissues and M5-stimulated keratinocytes. CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis.
genetics_GWAS	36591938	hsa-mir-492	Pancreatic Carcinoma	In this study, we first found that miR-492 in enhancer loci activated neighboring genes (NR2C1/NDUFA12/TMCC3) and promoted PaCa cell proliferation, migration, and invasion in vitro.
circulation_biomarker_diagnosis_ns	36591868	hsa-mir-10b	Breast Neoplasms	Furthermore, when PLPNs loaded with a CRISPRi plasmid that targets microRNA-10b (miR-10b) are used in combination with UMMD, it results in the effective repression of miR-10b in breast cancer, simultaneous disturbance of multiple cell migration and invasion-related signaling pathways, and a significant inhibition of lung metastasis.
other	36591806	hsa-mir-126	Prostatic Neoplasms	A high degree of MCs infiltration of the PCa tissue was associated with 1.2 times (p=0.0347) higher level of OPN expression and 1.7 (p=0.0051) and 1.65 (p=0.0087) times lower levels of miR-126 and miR-181a expression, respectively.
other	36591804	hsa-mir-3163	Uterine Cervical Neoplasms	Taken together, high expression of lncRNA CBR3-AS1 predicts poor prognosis in cervical cancer, and the lncRNA CBR3-AS1/miR-3163/LASP1 pathway plays a vital function in the modulation of cervical cancer cell proliferation and cancer stem cell-like properties.
lncRNA target	36591727	hsa-mir-495	Carcinoma, Non-Small-Cell Lung	3p/CCND1 axis, highlighting a promising target for NSCLC patients.
other	36591654	hsa-mir-662	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-4501	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-1258	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-7705	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
exosome	36591520	hsa-mir-320d	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
exosome	36591520	hsa-mir-4479	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
exosome	36591520	hsa-mir-6763	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
other	36591476	hsa-mir-221	Uterine Cervical Neoplasms	3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2).
other	36591476	hsa-mir-205	Uterine Cervical Neoplasms	3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2).
virus_miRNA	36591247	hcmv-mir-US33	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-UL112	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US5	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US29	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US4	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
other	36590967	hsa-mir-338	Pulmonary Disease, Chronic Obstructive	"3p correlated with airway eosinophilia and were able to distinguish ""pure eosinophilic"" COPD from other airway inflammatory subtypes (AUC 0.94 and 0.85, respectively)."
lncRNA target	36590397	hsa-mir-1	Colitis	Further analysis reveals that the number of proliferative epithelial cells, which characterizes the inflammatory process and the recovery of epithelia in colitis, is mainly determined by the inhibition of MIR31 on IL17RA.
lncRNA target	36590309	hsa-mir-361	Esophageal Neoplasms	Silencing the target genes of miR
target gene	36589606	hsa-mir-20a	Arthritis, Rheumatoid	LncRNA cardiac autophagy inhibitory factor is downregulated in rheumatoid arthritis and suppresses the apoptosis of fibroblast-like synoviocytes by promoting the maturation of miRNA-20a.
circulation_biomarker_diagnosis_up	36588450	hsa-mir-16	Arthritis, Rheumatoid	We aimed to evaluate miR-223 and miR-16 roles in monitoring RA activity and to investigate if there is a link between their plasma levels and US7 score.
other	36588450	hsa-mir-223	Arthritis, Rheumatoid	miR-16 and miR-223 levels were correlated with synovitis PDUS7 (r = 0.34, p < 0.01 and r= 0.25, P = 0.03, respectively). The miR-16 level was linked to synovitis GSUS7 and synovitis PDUS7 changes but miR-223 only linked to synovitis PDUS.
genetics_knock down_promote	36588357	hsa-mir-142	Liver Neoplasms	Injection with sh-CRNDE virus reduced in vivo tumor growth of liver cancer through up-regulation of miR-142 and down-regulation of EZH2 and HIF-1alpha. In conclusion, knockdown of CRNDE suppressed cell proliferation, glycolysis, and tumor growth of liver cancer through EZH2/miR-142/HIF-1alpha.
lncRNA target	36587882	hsa-mir-15	Inflammation	CONCLUSION: Collectively, our study revealed the previously undefined mechanistic role of Kabasura Kudineer (KK) that alleviates the LPS-induced oxidative damage associated with inflammation by inhibiting the miRNA5p/IL-10Ralpha axis.
other	36587497	hsa-mir-451a	Placenta Diseases	Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders.
other	36587497	hsa-let-7d	Placenta Diseases	Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders.
other	36587063	hsa-mir-28	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-203a	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-1	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-378a	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-203a	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-378a	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-1	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-28	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
genetics_overexpression_promote	36587050	hsa-mir-125a	ankylosing spondylitis 1	Accordingly, poorly expressed MEG3 and TNF alpha induced protein 3 (TNFAIP3) as well as overexpressed microRNA-125a-5p (miR-125a-5p) were noted in the serum of AS patients and in ASMSCs during the osteogenic induction process.
circulation_biomarker_diagnosis_ns	36586536	hsa-mir-96	Polycystic Ovary Syndrome	Furthermore, we demonstrated that the elevated circulating miR
genetics_knock down_promote	36586093	hsa-mir-1299	Carcinoma, Non-Small-Cell Lung	MiR-1299 inhibitor reversed circ_0020123 knockdown-mediated influence on malignant behaviors of NSCLC cells under TSIIA treatment.
lncRNA target	36586008	hsa-mir-361	Esophageal Neoplasms	3p or COL5A1 axis, indicating that BBOX1-AS1 might be a potential therapeutic target for EC therapy.
circulation_biomarker_diagnosis_ns	36585554	hsa-mir-188	Vascular Diseases	3p), and toll-like receptor 4 (TLR4) expression was determined via real-time quantitative polymerase chain reaction (RT-qPCR) in serum samples from AS patients and healthy volunteers.
other	36585230	hsa-mir-181c	Lung Neoplasms	Results UALCAN analysis displayed that the expression of miR-181c was significantly higher and RECK expression was significantly lower in lung cancer tissues compared to that in normal tissues.
other	36585203	hsa-mir-1	Glioblastoma	CONCLUSION: Our results demonstrated that NIPP is able to efficiently attenuate growth of GBM cells and suggest AKT1, ERK1/2 and miR-1 to be pivotal factors of NIPP-modulated cellular signalling.
transcription factor target	36585184	hsa-mir-877	Esophageal Squamous Cell Carcinoma	3p acts as a tumour suppressor gene in ESCC cells, and its down-regulation in ESCC tissues is associated with a poor prognosis.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4500	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-5191	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-5587	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-4469	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4803	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-5680	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4666a	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4661	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-183	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-382	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
lncRNA target	36584452	hsa-mir-16	Inflammation	CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis.
lncRNA target	36584452	hsa-mir-16	Sepsis	CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis.
genetics_knock down_suppress	36583803	hsa-mir-29c	Carcinoma, Hepatocellular	CONCLUSION: miR-29c, a key gene regulating HCC, is lowly expressed in HCC, its overexpression can remarkably inhibit the biological function of tumor cells.
genetics_overexpression_suppress	36583788	hsa-mir-758	Uterine Cervical Neoplasms	3p overexpression on CC cell progression.
lncRNA target	36583714	hsa-mir-34a	Liver Cirrhosis	The miR-34a-mediated ductular reactions may be functioning through Sirt
lncRNA target	36583660	hsa-mir-27a	Thyroid Cancer, Papillary	Our study highlights that DNAJC3-AS1 inhibits miR-27a-3p to promote CCBE1 expression, thereby facilitating PTC development.
genetics_overexpression_promote	36583484	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	3p weakened the promoting effect of overexpressed KPNA2 on LUSC malignant progression.
other	36583233	hsa-mir-15b	Coronary Artery Disease	RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups.
other	36583233	hsa-mir-15b	Heart Failure	RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups.
other	36583003	hsa-mir-4732	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-4732	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-631	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-513b	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-513b	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-631	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-1180	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-let-7b	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-let-7b	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-1180	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-6805	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-548av	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-548av	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-6805	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
genetics_GWAS	36582685	hsa-mir-216a	Colonic Neoplasms	In conclusions, lnc-LAMC2-1:1 SNP rs2147578 was involved in promoting COAD progression by targeting miR-216a-3p/HMGB3, and this study will provide a novel molecular target for COAD.
exosome	36582605	hsa-mir-122	Thyroid Neoplasms	Cancer stem cell-like cells-derived exosomal lncRNA CDKN2B-AS1 promotes biological characteristics in thyroid cancer via miR-122-5p/P4HA1 axis.
other	36582505	hsa-mir-122	Chilblain lupus	METHODS: The expression of adenosine deaminase acting on RNA-1 (ADAR1) and miR-122 was evaluated in liver tissues from patients with CHB concurrent NAFLD.
genetics_overexpression_suppress	36582030	hsa-mir-700	Skin Diseases	MiR5p overexpression or GPX4 downregulation inhibited the circ-Ash1l protective effects of UV-induced endothelial progenitor cell (EPC) damage.
genetics_overexpression_promote	36581129	hsa-mir-663b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: Our study illustrated that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis.
lncRNA target	36581048	hsa-mir-124	Liver Injury	Collectively, our findings suggest that miR-124 can potentially serve as a predictive biomarker for HBV-ACLF prognosis and may represent a promising therapeutic target for relieving severe liver injury resulting from cytokine storms.
lncRNA target	36580691	hsa-mir-181b	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
lncRNA target	36580691	hsa-mir-542	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
lncRNA target	36580691	hsa-mir-3690	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
circRNA target	36580535	hsa-mir-203a	Osteosarcoma	Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS.
circRNA target	36580535	hsa-mir-208b	Osteosarcoma	Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS.
other	36580437	hsa-mir-515	Pre-Eclampsia	This study tried to elicit the functional mechanism of miR5p in trophoblast cell behaviors in PE.
transcription factor target	36579994	hsa-mir-233	Carcinoma, Hepatocellular	CONCLUSIONS: Our data suggest a potential role for miR3p as a prognostic as well as a therapeutic target for HCC.
lncRNA target	36579395	hsa-mir-141	Triple Negative Breast Neoplasms	3p could suppress autophagy and inhibit proliferation, migration, and invasion by targeting Malat1 in TNBC cells under hypoxia.
other	36579331	hsa-mir-296	Sepsis	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-650	Acute Kidney Injury	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-296	Acute Kidney Injury	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-650	Sepsis	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
genetics_overexpression_suppress	36578555	hsa-mir-122	Carcinoma, Renal Cell	Overexpression of circ_DENND1B regulated TIMP2 level by inhibiting miR
lncRNA target	36578092	hsa-mir-130a	Breast Neoplasms	CONCLUSION: This study presents a mechanism involving the DSCAM-AS1/miR-130a/ESR1 genomic axis through which progesterone impedes breast cancer cell invasion and migration.
transcription factor target	36578050	hsa-mir-4443	Esophageal Squamous Cell Carcinoma	CONCLUSION: In this study, miR-4443 is found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, which provides a new perspective and clue to alleviate radioresistance.
circulation_biomarker_diagnosis_ns	36577694	hsa-mir-206	Depression	OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients. miRNA-206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS.
circulation_biomarker_diagnosis_ns	36577694	hsa-mir-206	Anxiety Disorders	OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients.
circulation_biomarker_diagnosis_up	36577155	hsa-mir-21b	Graft vs Host Disease	Th1, Th17 and Treg cells were respectively isolated from peripheral blood CD4 T cells of allo-HSCT patients, and we found that proportions of Th1 and Th17 were markedly increased, while Treg proportion was significantly decreased in aGVHD patients post transplantation compared with non-aGVHD patients, accompanied by decreased ADAR1 and increased miR-21b levels. Collectively, ADAR1 suppresses miR-21b production and improves Foxp3-mediated Treg cell function to inhibit the progression of aGVHD after allo-HSCT.
lncRNA target	36577153	hsa-mir-34a	Neuralgia	CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway.
lncRNA target	36577153	hsa-mir-34a	Spinal Cord Injuries	CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway.
circulation_biomarker_diagnosis_ns	36577123	hsa-mir-375	Liver Neoplasms	Conclusions: According to our meta-analysis, measuring serum miR-375 has high sensitivity and specificity, which will facilitate its clinical application in liver cancer monitoring.
other	36577032	hsa-mir-503	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-10a	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-let-7d	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-106b	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-93	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
target gene	36576783	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis.
target gene	36576714	hsa-mir-378a	Hepatoblastoma	LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
genetics_knock down_promote	36575638	hsa-mir-92a	Coronary Artery Disease	Loss of LPP3 in CAD is associated with an increase in the LPP3 inhibitor, miR-92a.
lncRNA target	36575638	hsa-mir-92a	Fibromuscular Dysplasia	miR-92a is elevated in CAD arterioles (fold change: 1.9 0.01 P = 0.04), while inhibition of miR-92a restored NO-mediated FMD (CAD), and enhancing miR-92a expression (non-CAD) elicited H(2) O(2) -mediated dilatation (P &lt; 0.0001). Inhibition of miR-92a restores nitric oxide-mediated FMD in the microvasculature of CAD patients.
other	36575638	hsa-mir-92a	Vascular Diseases	We investigated the role of LPP3 and miR-92a as a mechanism for microvascular dysfunction in CAD.
other	36575500	hsa-mir-122	Muscular Dystrophy, Facioscapulohumeral	3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression.
circulation_biomarker_prognosis_ns	36575500	hsa-mir-23	Muscular Dystrophy, Facioscapulohumeral	CONCLUSIONS: Although limited by the small number of patients included in this study, we propose here a specific combination of circulating miR
circulation_biomarker_diagnosis_ns	36575500	hsa-mir-23b	Muscular Dystrophy, Facioscapulohumeral	Four of these circulating miRs (miR
other	36575500	hsa-mir-192	Muscular Dystrophy, Facioscapulohumeral	3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression.
circulation_biomarker_diagnosis_ns	36575500	hsa-mir-19b	Muscular Dystrophy, Facioscapulohumeral	Four of these circulating miRs (miR
lncRNA target	36575320	hsa-mir-29a	lacrimal gland adenoid cystic carcinoma	miR-29a-3p can specifically target the 3' UTR of Quaking mRNA and down-regulate Quaking expression, thereby inhibiting the proliferation, migration, and epithelial-mesenchymal transition of LACC cells.
genetics_knock down_promote	36575008	hsa-mir-342	Carcinoma, Non-Small-Cell Lung	3p) sponge, and circ_0006220 knockdown-induced changes on the phenotypes of NSCLC cells were largely overturned by the knockdown of miR
lncRNA target	36574754	hsa-mir-19b	Carcinoma, Endometrioid	CONCLUSIONS: LINC01857 exacerbated EC cell malignant behaviors via the miR-19b-3p/ELAVL1/MYCN axis.
circRNA target	36574090	hsa-mir-142	Lung Neoplasms	Taken together, circTAB2 serves as an inhibitory role in lung cancer through a novel circTAB2 /miR-3142 /GLIS2 /AKT pathway and could be exploited a novel marker in lung cancer.
circulation_biomarker_diagnosis_up	36573890	hsa-mir-124	Inflammatory Bowel Diseases	Consistently, miR-124 expression was upregulated in the rectal biopsies and blood samples of UC patients and a parallel reduction in Th17 cells and IL17a levels was observed in serum samples.
genetics_knock down_promote	36573325	hsa-mir-548i	Carcinoma, Non-Small-Cell Lung	Moreover, miR-548I was targeted by circ_0008003, and miR-548I knockdown reversed the influence of circ_0008003 silence on NSCLC progression. CONCLUSION: Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR-548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis.
other	36573168	hsa-mir-146a	psoriasis 1	Moreover, expression levels of miR-146a-3p were higher in psoriatic HDMECs than in normal controls.
other	36573051	hsa-mir-21	Rectal Neoplasms	5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma.
other	36573051	hsa-mir-455	Rectal Neoplasms	5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma.
genetics_overexpression_suppress	36572886	hsa-mir-338	Osteoarthritis	3p silencing/overexpression) were incubated with IL-1beta-induced ATDC5 cells, followed by evaluation of the chondrocyte proliferation, degradation, and inflammation injury.
transcription factor target	36572643	hsa-mir-297	Endometriosis	METHODS: ESCs were isolated from infertile endometriosis and normal patients and were transfected with miR-297 mimic or miR-297 inhibitor or respective control.
circRNA target	36572073	hsa-mir-556	Osteosarcoma	5p inhibitor.
other	36571367	hsa-mir-138	Diabetic Neuropathies	These findings suggest that the circ_0002538/miR5p/PLLP axis can promote the migration of Schwann cells in diabetic peripheral neuropathy patients, improving myelin sheath structure and nerve function.
transcription factor target	36571232	hsa-mir-132	Colonic Neoplasms	3p regulates colon cancer cell sensitivity to antibody-mediated CDC by directly targeting CD55.
exosome	36570020	hsa-mir-181a	Lung Injury	CONCLUSION: Consequently, we concluded that ADSC-derived exosomal miR-181a-5p alleviated Klebsiella pneumonia infection-induced lung injury by targeting STAT3 signaling. ADSC-derived exosomal miR-181a-5p may serve as a potential candidate for the treatment of Klebsiella pneumonia infection-induced lung injury.
lncRNA target	36569509	hsa-mir-200a	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
lncRNA target	36569509	hsa-mir-375	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
lncRNA target	36569509	hsa-mir-200b	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
genetics_knock down_promote	36569483	hsa-mir-215	Pulmonary Fibrosis	5p knockdown on PQ-induced pulmonary fibrosis.
lncRNA target	36569479	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	We validate that RSV influences mitophagy and PTX resistance in NSCLC via ZFAS1/miR
transcription factor target	36569394	hsa-mir-211	Dyspepsia	Targeting miR-211 or the MAPK pathway may be a potential intervention for FD.
target gene	36569343	hsa-mir-3677	Leukemia, Monocytic, Acute	Ginsenoside Rk3 Inhibits the Extramedullary Infiltration of Acute Monocytic Leukemia Cell via miR-3677-5p/CXCL12 Axis.
other	36568518	hsa-mir-30	Stomach Neoplasms	DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis.
lncRNA target	36567178	hsa-mir-376b	Carcinoma, Hepatocellular	Bioinformatics analysis based on Lncbase, miRDB and TargetScan databases showed MK5-AS1 competitively bound to miR-376b-5p that prevented epithelial cell transforming sequence 2 (ECT2) from miRNA-mediated degradation, thus facilitated HCC metastasis.
exosome	36567149	hsa-mir-145	Gynatresia	Exosomal miR
exosome	36567149	hsa-mir-145	adhesions of uterus	CONCLUSIONS: UCMSC-exos might reverse endometrial stromal cell fibrosis by regulating the miR5p/ZEB2 axis, representing a potential novel strategy to promote endometrial repair.
lncRNA target	36567017	hsa-mir-205	Hashimoto Disease	Under stress conditions, such as ultraviolet radiation, we in addition show HITT stability increases as a consequence of MiR-205 downregulation, inhibiting MFN2-mediated fusion and leading to apoptosis.
transcription factor target	36566019	hsa-mir-337	Urinary Bladder Neoplasms	3p may act as a candidate therapeutic target in BC treatments.
other	36566010	hsa-mir-210	Glaucoma	3p level/activity represents a potential new therapeutic strategy for POAG.
genetics_overexpression_promote	36565612	hsa-mir-2114	Ovarian Neoplasms	Cx26 overexpression and miR
genetics_overexpression_promote	36565360	hsa-mir-4299	Pancreatic Carcinoma	ADAM17 overexpression could reverse miR-4299 effects on PC cell viability, invasion, apoptosis, and immune escape.
circulation_biomarker_diagnosis_ns	36564725	hsa-mir-338	Sepsis	RESULTS: The levels of miR3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05).
circulation_biomarker_diagnosis_ns	36564725	hsa-mir-338	Kidney Diseases	3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05).
other	36564279	hsa-mir-548aq	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
other	36564279	hsa-mir-4710	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
other	36564279	hsa-mir-367	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
transcription factor target	36564067	hsa-mir-126	Wounds and Injuries	5p may be a molecular target for MI treatment.
lncRNA target	36564067	hsa-mir-126	Myocardial Infarction	5p may be a molecular target for MI treatment.
circRNA target	36563841	hsa-mir-351	Diabetes, Gestational	CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR
circRNA target	36563841	hsa-mir-3102	Diabetes, Gestational	CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR
other	36563751	hsa-mir-143	Glima	Brain lower and grade glioma patients who had higher levels of TP53, hsa-miR-25, hsa-miR-34, hsa-miR-222, and hsa-miR-143 had a reduced likelihood of survival.
transcription factor target	36562844	hsa-mir-338	Coronary Disease	3p may be a diagnostic biomarker and therapeutic target for coronary heart disease.
circRNA target	36562476	hsa-mir-761	Triple Negative Breast Neoplasms	In-depth mechanism analysis indicated that circDUSP1 acts as an endogenous sponge of miR-761 to reduce its suppression on target gene DACT2 expression in TNBC.
lncRNA target	36561980	hsa-mir-142	Myocardial Reperfusion Injury	3p can negatively regulate dopamine receptor D2 (DRD2), which acted as an anti-inflammatory factor to suppress NF-kappaB-dependent inflammation and prevent MIRI.
other	36561976	hsa-mir-141	Mitochondrial Diseases	MicroRNA-141 (miR-141) has been implicated in the mitochondrial dysfunction in cell-based models of oxidant stress.
other	36561887	hsa-mir-200b	Nervous System Diseases	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-200b	Schizophrenia	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Alzheimer Disease	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Nervous System Diseases	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Schizophrenia	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-200b	Alzheimer Disease	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
lncRNA target	36561847	hsa-mir-4270	Colonic Neoplasms	More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells.
lncRNA target	36561842	hsa-mir-4711	Intervertebral Disc Degeneration	Overall, silencing ZFAS1 inhibits IDD progression by reducing NP cell apoptosis and ECM degradation through the miR5p/AAK1 axis.
other	36561253	hsa-mir-218	Aortic Aneurysm, Abdominal	BACKGROUND: To explore the effects of miRNA5p on inflammation and extracellular matrix proteins of vascular smooth muscle cell line in abdominal aortic aneurysm (AAA).
other	36561136	hsa-mir-186	Alzheimer Disease	5p were determined by COX regression, AD transformation status and aberrant miRNAs.
other	36561136	hsa-mir-425	Alzheimer Disease	5p were determined by COX regression, AD transformation status and aberrant miRNAs.
circulation_biomarker_diagnosis_ns	36561056	hsa-mir-21	Essential Hypertension	CONCLUSIONS: Circulating serum levels of miR-21 are increased in elderly patients with EH with LA dilation.
exosome	36560694	hsa-mir-21	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-548c	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-23a	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-26a	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
other	36560686	hsa-mir-6741	COVID-19	In sum, we show that circulatory miR5p may serve as a prognostic biomarker effectively predicting mortality risk and LOS of hospitalized COVID-19 patients.
other	36559150	hsa-mir-126	Ischemia	In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia.
other	36558525	hsa-mir-28	Arthritis	OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a.
other	36558525	hsa-mir-199a	Arthritis	OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a.
lncRNA target	36558243	hsa-mir-146a	Inflammation	Our previous studies demonstrated that cerium oxide nanoparticles (CNPs) conjugated with therapeutic microRNA146a (miR146a) could effectively enhance wound healing by targeting the NFkappaB pathway, reducing oxidative stress and inflammation.
other	36556492	hsa-mir-16	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-27a	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-195	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-107	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556329	hsa-mir-24	COVID-19	Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework.
other	36556329	hsa-mir-148a	COVID-19	Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework.
genetics_knock down_suppress	36556251	hsa-mir-92b	Bone Diseases	Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis.
genetics_knock down_suppress	36556251	hsa-mir-92b	Osteoporosis	Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis.
circulation_biomarker_diagnosis_up	36556238	hsa-mir-1296	Thyroid Cancer, Papillary	Taken together, our findings suggested that circulating exosomal miRNAs, particularly miR
transcription factor target	36555553	hsa-mir-503	Head and Neck Neoplasms	Overall, this study demonstrates that miR-503 suppresses HNC malignancy by inhibiting cell invasion through the Wnt signaling pathway via the WNT3A/MMP molecular axis.
target gene	36555545	hsa-mir-1	Carcinoma, Hepatocellular	Thymoquinone Suppresses Angiogenesis in DEN-Induced Hepatocellular Carcinoma by Targeting miR-1-3p.
other	36555437	hsa-mir-19	Obesity	We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced.
other	36555437	hsa-mir-19a	Obesity	Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity.
other	36555437	hsa-mir-19b	Obesity	Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity.
other	36555437	hsa-mir-19	Obesity, Morbid	We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced.
lncRNA target	36555418	hsa-mir-193b	Muscular Diseases	As a well-known cancer-related miRNA, miR-193b-3p is enriched in skeletal muscle and dysregulated in muscle disease.
transcription factor target	36555301	hsa-mir-200c	Cardiovascular Diseases	In conclusion, downregulated miR-200c-3p in T1DM correlated with diabetic control, VEGF signaling, inflammation, vascular health and targeting VEGF signaling, and may define subclinical CVD.
lncRNA target	36553675	hsa-mir-122b	Oropharyngeal Neoplasms	Our data suggest, for the first time, that ADAM3A and ADAM5 pseudogene-inherited CNV could modulate OPSCC occurrence and prognosis, possibly through the interaction of ADAM5 pseudogene transcript, miR-122b-5p, and ADAM9.
lncRNA target	36553610	hsa-mir-181c	Carcinoma, Hepatocellular	The functional enrichment bioinformatics analyses of miR-181c-5p-downregulated targets in HCC indicated that miR-181c-5p targets were significantly enriched in multiple pathways and biological processes involved in HCC development.
circulation_biomarker_diagnosis_ns	36553586	hsa-mir-375	Prostatic Neoplasms	Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR.
circulation_biomarker_prognosis_up	36553586	hsa-mir-21	Prostatic Neoplasms	The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant.
genetics_overexpression_promote	36553522	hsa-mir-664a	Carcinoma, Hepatocellular	Alcohol Dehydrogenase 4 (ADH4) is a well-known prognostic protein biomarker for predicting the survival outcomes of patients with hepatocellular carcinoma whose expression is regulated by miR-664a-3p, which is upregulated in HCC. In summary, our interaction analyses results predict the significance of the MEG3/miR-664a-3p/ADH4 axis, where MEG3 downregulation results in miR-664a-3p overexpression and the subsequential underexpression of ADH4 in HCC, as a novel axis of interest that demands further validation.
other	36553468	hsa-mir-1268a	Liver Diseases	3p, which might play roles in hepatic fibrosis.
transcription factor target	36552896	hsa-mir-130a	Non-alcoholic Fatty Liver Disease	MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after L. salivarius SNK-6 alleviated liver damage partly via the miR-130a-5p/MBOAT2 signaling pathway.
circulation_biomarker_diagnosis_up	36552891	hsa-mir-19b	Lupus Erythematosus, Systemic	After isolation of peripheral blood mononuclear cells (PBMC) from the SLE group and healthy group and treatment of SLE-derived PBMCs with UC-BSC-derived exosomes, the mRNA levels of corresponding factors in cells under different treatments were determined by RT-PCR, Th17/Treg content was analyzed by FCM (flow cytometry), and the targeted binding of microRNA-19b (miR-19b) to KLF13 was identified by in vitro experiments and bioinformatics analysis. According to the study's findings, SLE patients have dysregulated expression of the genes miR-19b and KLF13, and UC-BSC exosomes could regulate Th17/Treg cell balance and inflammatory factor expression in SLE patients through miR-19b/KLF13.
other	36552749	hsa-mir-143	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-1	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-214	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-125b	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-200	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
transcription factor target	36552609	hsa-mir-137	Diabetes Mellitus	This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.
transcription factor target	36552609	hsa-mir-29b	Diabetes Mellitus	This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.
exosome	36551866	hsa-mir-210	Endometriosis	The expression of miR3p was increased in both exosomes and the eutopic endometrium in patients with endometriosis through miRNA sequencing, which could also reduce the proportion of CD80(+) macrophages.
lncRNA target	36551768	hsa-mir-186	Osteosarcoma	Furthermore, circDOCK1 upregulated DNMT3A expression through sponging miR-186 to regulate the progression of OS. CONCLUSIONS: CircDOCK1 promotes OS progression by interacting with miR-186/DNMT3ADNMT3A, representing a novel therapeutic approach.
other	36551704	hsa-mir-335	Adenocarcinoma of Lung	A ceRNA network of KCNQ1OT1/miR5p/DMRT3 was constructed in LUAD.
other	36551202	hsa-mir-126	Non-alcoholic Fatty Liver Disease	NAFLD+LOLA+VitE decreased miR-122, miR-33a and miR-186, and increased miR-126 (p &lt; 0.05, for all) in comparison to NAFLD and NAFLD+VitE.
exosome	36551009	hsa-mir-451	Prostatic Neoplasms	We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis.
exosome	36551009	hsa-mir-21	Prostatic Neoplasms	We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis.
genetics_knock down_promote	36550594	hsa-mir-942	Glioma	LINC01018 knockdown and miR
genetics_overexpression_promote	36550514	hsa-mir-204	Arthritis, Rheumatoid	5p, and its overexpression rescued the repressive impact of miR
other	36550370	hsa-mir-158	Mycoses	Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396.
other	36550370	hsa-mir-156	Mycoses	Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396.
lncRNA target	36550153	hsa-mir-20a	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-375	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-17	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-135b	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-29c	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550019	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Hsa_circ_0092887 depletion alleviated PTX-resistance in NSCLC cells via modulating the miR
other	36549862	hsa-mir-92	Heart Failure	Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin.
other	36549862	hsa-mir-21	Heart Failure	Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin.
circulation_biomarker_diagnosis_ns	36549775	hsa-mir-377	Acute Coronary Syndrome	The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats.
circulation_biomarker_diagnosis_ns	36549765	hsa-mir-338	Respiratory Distress Syndrome, Newborn	Pearson's correlation analysis evaluated the correlation between serum miR
circulation_biomarker_diagnosis_ns	36549765	hsa-mir-338	Respiratory Distress Syndrome	Pearson's correlation analysis evaluated the correlation between serum miR
other	36549352	hsa-mir-29a	Pulmonary Fibrosis	The current study investigated the ability of THY to modulate oxidative stress, inflammation, miR-29a/TGF-beta expression, and PI3K/phospho-Akt signaling in lung fibrosis.
target gene	36548909	hsa-mir-216b	Stomach Neoplasms	LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.
exosome	36548450	hsa-mir-124	Cerebral Hemorrhage	In conclusion, ICH-exos delivered lncRNA SND1-IT1 to HMC3 cells, and exosomal lncRNA SND1-IT1 can regulate cell viability and apoptosis to influence HMC3 cell growth via the SND1-IT1/miR3p/MTF1 axis.
lncRNA target	36548440	hsa-mir-1250	Triple Negative Breast Neoplasms	5p acts as tumor suppressor in TNBC cells and its induction by therapeutics might be a novel strategy for the disease treatment.
genetics_overexpression_promote	36546770	hsa-mir-143	Colonic Neoplasms	overexpressing cells restored 5-FU resistance of CRC cells.
other	36546578	hsa-mir-21	Endometriosis	Additionally, a negative correlation of METTL3 was identified with miR5p along with a positive correlation with the WIF1 mRNA in EM tissues.
genetics_overexpression_suppress	36545728	hsa-mir-31	Melanoma	Overexpression of miR
exosome	36545680	hsa-mir-449a	Osteosarcoma	Our findings not only reveal a novel mechanism of miR-449a /CCNB1 in OS but also had laid the groundwork for further investigation and analysis in the field of exosome engineering.
lncRNA target	36545127	hsa-mir-642a	Colonic Neoplasms	Analysis of the potential upstream miRNA of MACC1 showed that miR-642a-5p was downregulated in COAD and was negatively correlated with MACC1 expression. In summary, these findings suggest that MACC1 contributes to COAD progression and immune cell infiltration via the ZFAS1/miR-642a-5p/MACC1 axis.
genetics_overexpression_suppress	36544920	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	COL5A1 overexpression reversed the inhibitory effects of miR
lncRNA target	36544854	hsa-mir-124	Inflammation	An ameliorative action of Pio was demonstrated via decreased CD86 immunoexpression, upregulation of miRNA-124, decreased STAT3 expression and beneficial anti-inflammatory effects. Pio exerted its anti-inflammatory effects via PPARgamma/miRNA-124/STAT3 signaling.
other	36544782	hsa-mir-128	Carcinoma, Non-Small-Cell Lung	3p for participating in LUSC progression.
other	36544695	hsa-mir-23b	Squamous Cell Carcinoma of Head and Neck	Finally, a ceRNA network (SMS/hsa-miR-23b-3p/KTN1-AS1 and VPS9D1-AS axis) was constructed based on the co-expression and survival analyses in HNSC.
target gene	36544654	hsa-mir-200a	Neuroblastoma	Corin is regulated by circ-0012397/miR-200a-3p and inhibits the oxygen-glucose deprivation-induced apoptosis of SHSY5Y neuroblastoma cells.
transcription factor target	36544422	hsa-mir-204	Fetal Growth Retardation	CONCLUSIONS: Inhibiting miR-204 can improve the learning and memory functions of neonatal rats with IUGR, possibly by targeted activation of the BDNF/TrkB signaling pathway.
lncRNA target	36544170	hsa-mir-200a	Osteosarcoma	CONCLUSION: LncEBLN3P is upregulated in osteosarcoma and increases the MTX resistance in osteosarcoma cells through downregulating miR-200a-3p, which in turn promoted the EMT process of osteosarcoma cells by increasing the OGT.
other	36543894	hsa-let-7b	Acute Kidney Injury	Let-7b-5p downregulation may lead to increased renal AKI susceptibility, thus indicating that this miRNA is a potential driver of the MSC treatment response in AKI.
lncRNA target	36543302	hsa-mir-181a	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: In summary, our study demonstrates that LINC01232 expression increases in LUSC tissues and cell lines and promotes LUSC progression by modulating the miR-181a-5p/SMAD2 signaling, providing new potential drug targets for LUSC treatment.
lncRNA target	36542990	hsa-mir-200c	Colorectal Neoplasms	Mechanistically, we proved that circ-ZEB1 could directly bind with miR-200c and functioned as miR-200c sponge to exert its biological functions in CRC cells. In conclusion, circ-ZEB1 could promote CRC cells progression, EMT, and chemoresistance via acting on miR-200c, elucidating a potential therapeutic target to inhibit CRC progression.
other	36542459	hsa-mir-19	Breast Neoplasms	Collectively, these results demonstrated, for the first time, that SFN regulates the miR-19/PTEN axis to exert protective effects against BBP-mediated breast cancer promotion, suggesting a new potential role for SFN (or SFN-rich foods) in phthalate antagonism.
other	36542326	hsa-mir-149	Pituitary Neoplasms	dependent expression of ADAM12 and MMP-14.
circRNA target	36542208	hsa-mir-362	Colorectal Neoplasms	HMGB3 acted as a downstream target for miR
transcription factor target	36541921	hsa-mir-124	Memory Disorders	It is possible that miRNA-124 can be used as a new target for the pathogenesis of memory impairment, including age-associated neurodegenerative diseases such as Alzheimer's disease.
lncRNA target	36541900	hsa-mir-212	Pulmonary Disease, Chronic Obstructive	In conclusion, LINC00599 facilitated CSE-induced cell apoptosis and inflammation response, while inhibiting the cell viability and proliferation in COPD progression via modulating miR
other	36541451	hsa-mir-24	Pneumothorax	In conclusion, the miRNA-24 levels were significantly decreased in children with PSP.
other	36541451	hsa-mir-21	Pneumothorax	In conclusion, the miRNA-24 levels were significantly decreased in children with PSP.
circulation_biomarker_diagnosis_up	36541422	hsa-mir-146b	Pre-Eclampsia	There are a variety of abnormal expression miRNAs in PE, however, the relationship between miR-146b-5p and PE has yet to be fully elucidated.What do the results of this study add? We first found that expression levels of serum miR-146b-5p in the first trimester were significantly higher in PE than in a normal pregnancy group.
genetics_knock down_suppress	36541402	hsa-mir-545	Pancreatic Neoplasms	Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2.
genetics_GWAS	36541377	hsa-mir-4513	Coronary Disease	This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population.
genetics_GWAS	36541377	hsa-mir-146a	Coronary Disease	This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population.
lncRNA target	36541217	hsa-mir-34a	Fatty Liver	Taken together, ATM is a promising therapeutic agent against MAFLD that reduces lipid deposition by suppressing miR-34a-5p and upregulating PPARalpha.
lncRNA target	36541023	hsa-mir-144	Periprosthetic Fractures	3p/RUNX1 pathway may provide a potential target for prevention of PPOL.
other	36540394	hsa-mir-155	COVID-19	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540394	hsa-mir-155	Periodontitis	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540394	hsa-mir-155	Diabetes Mellitus	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540376	hsa-mir-137	Alzheimer Disease	Furthermore, AD induction was performed by aluminum chloride (Alcl(3)), animals were allocated, and brain hippocampus tissue was isolated for ELISA and qRT-PCR analysis of malondialdehyde (MDA), nuclear factor kappa B (NF-kB), and microRNA-137 (miR-137) coupled with immunohistochemical amyloid-beta (Abeta(1-)42) expression and histopathological finding.
other	36540097	hsa-mir-582	Myocardial Infarction	5p/F2RL2 axis, providing novel biomarkers for MI treatment.
genetics_knock down_promote	36540014	hsa-mir-142	Osteoarthritis	5p reversed the suppressive effects of circ-NT5C2 silencing on the OA progression in vitro, and NAMPT overexpression also attenuated the effects of miR
circulation_biomarker_prognosis_ns	36540006	hsa-mir-146a	Lymphoma, Large B-Cell, Diffuse	This study aims to explore the role of serum miR-146a in predicting the prognosis of DLBCL. CONCLUSION: Our results suggest that the level of serum miR-146a can serve as a potential prognostic biomarker for DLBCL patients.
other	36539984	hsa-mir-21	Lung Neoplasms	Intriguingly, microRNA-21, an early marker of lung cancer, can be detected without being transcribed in advance by an innovative signal amplification strategy using ferritin-mediated aggregation of hydrophilic nitroxide radical monomers as an electrochemical biosensor.
lncRNA target	36539807	hsa-mir-194	Carcinoma, Pancreatic Ductal	5p/SOCS2 axis may be a potential therapeutic target for PDAC patients.
genetics_knock down_promote	36539702	hsa-mir-338	Colorectal Neoplasms	CONCLUSION: This study demonstrated that circ_0039857 knockdown suppressed CRC malignant progression through miR3p/RAB32 axis.
genetics_knock down_promote	36539576	hsa-mir-492	Breast Neoplasms	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-183	Breast Neoplasms	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-183	Precancerous Conditions	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-492	Precancerous Conditions	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_suppress	36539369	hsa-mir-644a	Esophageal Neoplasms	Besides that, inhibition of miR-644a abolished the promoting action of hsa_circ_0007380 knockdown on esophagus cancer apoptosis and radiosensitivity.
lncRNA target	36539368	hsa-mir-1253	Prostatic Neoplasms	miR-1253 was a downstream molecule of circ-ABCC4, and circ-ABCC4 depletion-mediated anti-cancer impacts in PCa cells were partly counteracted by decreasing miR-1253 abundance. miR-1253 targeted SOX4 mRNA, and miR-1253 blocked PCa cell malignant phenotypes partly by targeting SOX4.
genetics_knock down_promote	36539367	hsa-mir-582	Urinary Bladder Neoplasms	5p targeted KPNA2, and KPNA2 overexpression counteracted the inhibitory impact of miR
lncRNA target	36539365	hsa-mir-338	Carcinoma, Non-Small-Cell Lung	Silencing of circPIM3 suppressed Tax resistance in Tax-resistant NSCLC cells through regulation of the miR3p/TNFAIP8 axis.
genetics_knock down_promote	36539364	hsa-mir-1299	Carcinoma, Non-Small-Cell Lung	MiR-1299 was a target of circ_0058608, and the effects of circ_0058608 knockdown on NSCLC cell progression and taxol resistance were reversed by miR-1299 inhibition.
other	36539363	hsa-mir-451a	Laryngeal Neoplasms	At the same time, miR-451a was found to be the most significantly downregulated miRNA in laryngeal squamous cell carcinoma tissues.
transcription factor target	36539014	hsa-mir-19	Cardiomyopathies	The present study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. CONCLUSIONS: Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways.
lncRNA target	36539001	hsa-mir-142	Breast Neoplasms	This study suggests that GNB2 is an essential target for miR
lncRNA target	36538851	hsa-mir-515	Osteoarthritis	CONCLUSION: FTO alleviated OA in an m6A-dependent manner via the miR5p/TLR4/MyD88/NF-kappaB axis.
other	36538560	hsa-mir-155	Osteoarthritis	As the micro-RNA miR-155 has been found increased in OA chondrocytes, we investigated the effects of high pressure on the expression of the miR-155 host gene Mir155hg.
lncRNA target	36538560	hsa-mir-155	Cartilage Diseases	The chondrocyte progenitor cell line ATDC5 was pressurized under hydrostatic pressure up to 25 MPa and the expression of Mir155hg or the resulting micro-RNAs were measured; pharmacological inhibitors were used to identify the signaling pathways involved in the regulation of Mir155hg.
genetics_GWAS	36538546	hsa-mir-20a	Polycystic Kidney Diseases	We compared the relative expression profile of miR-20a, -192, -365, -15b-5p, and 5p from plasma and serum samples of nine domestic cats with PKD1 mutation, detected by polymerase chain reaction (PCR), and a control group (n = 10).
lncRNA target	36538280	hsa-mir-576	Endometrial Neoplasms	5p promoted proliferation and metastasis capacity of EC cells by inhibiting ZBTB4 expression.
circRNA target	36538242	hsa-mir-135a	Urinary Bladder Neoplasms	Mechanically, circSTK39 could sponge with miR-135a-5p, thus inhibiting NR3C2-mediated EMT processes in the BCa progression. In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa.
transcription factor target	36538194	hsa-mir-155	Meningioma	The findings suggest that miR5p play an important role in the pathogenesis of meningioma and may represent potential therapeutic targets for its anti-PD-L1 immunotherapy.
circulation_biomarker_diagnosis_ns	36538076	hsa-mir-138	Acute Lung Injury	Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR
circulation_biomarker_diagnosis_ns	36538076	hsa-mir-138	Sepsis	Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR
lncRNA target	36537157	hsa-mir-9	Acute Lung Injury	5 p in ALI via regulating macrophage polarization.
other	36537124	hsa-mir-4640	Osteoarthritis	5p/NOTCH2 axis stimulates the Notch pathway to promote the transcription of inflammatory cytokines (IL33, IL17F and IL6), consequently facilitating OA progression in murine chondrocytes.
circulation_biomarker_prognosis_ns	36537076	hsa-mir-3201	Carcinoma, Hepatocellular	Conclusions: Blood miR-3201 could be used as a prognostic biomarker for curative therapy response and OS in HCC.
transcription factor target	36536941	hsa-mir-186	Atherosclerosis	CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1.
transcription factor target	36536941	hsa-mir-186	Myocardial Infarction, Acute	CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1.
other	36536870	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: miRNA-145 is significantly altered in OSCC in our patient population and its reduced values carry a poor prognosis.
other	36536516	hsa-mir-28	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: PUM2 plays as a novel oncogenic RBP in T-ALL by competitively binding to RBM5 mRNA with miR5p.
genetics_knock down_promote	36536496	hsa-mir-1179	Pancreatic Carcinoma	Moreover, the miR-1179 inhibitor reversed the regulation of circ_0000284 knockdown on PC cell progression.
other	36536183	hsa-mir-122	Celiac Disease	3p was significantly increased in CD patients relative to control subjects (p = 0.049).
transcription factor target	36536183	hsa-mir-197	Celiac Disease	Increased expression of miR3p with a final protective effect on Occludin expression can be further studied as a complement therapeutic target for Celiac disease.
transcription factor target	36535956	hsa-mir-126	Carcinoma, Hepatocellular	5p, one of the tumor-suppressive genes commonly decreased in HCC, was found negatively expressed and correlated with SNRPF1, and a specific region of SNRPF1 transcript is directly binding to miR
other	36535942	hsa-mir-378	Pancreatic Carcinoma	The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival.
other	36535942	hsa-mir-378a	Pancreatic Carcinoma	The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival.
circRNA target	36535407	hsa-mir-495	Leukemia	3p expression is important in the malignant phenotype of CML and TKI resistance mechanisms and could be a useful biomarker and a potential therapeutic target to eradicate CML.
target gene	36535369	hsa-mir-486	Immunoglobulin G4-Related Disease	Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
circulation_biomarker_diagnosis_ns	36535313	hsa-mir-133a	Diabetes Mellitus, Type 2	So, this study examined the effects of eight weeks combination of 250 mg of UA per day per kilogram of body weight of rat as well as resistance/endurance training on miR-133a expression across serum, bone marrow, skeletal muscle, and Connexin 43 (Cx43)-Runt-related transcription factor 2 (Runx2) signaling axis in high-fat diet and low-dose streptozotocin-induced T2D (here, HFD/STZ-induced T2D). In conclusion, only eight weeks of resistance-type exercise could affect miR-133a profile in muscles and osteoblast differentiation biomarker RUNX2 in aged T2D model of rats.
other	36535134	hsa-mir-124	Brain Ischemia	3p and Nrep level in the MCAO model were found to be lower in the model predicted by bioinformatics than in the sham-operated group.
genetics_overexpression_promote	36535076	hsa-mir-181b	Colorectal Neoplasms	To elucidate the influence of CAFs-derived exosome miR-181b-3p on CRC, we overexpressed and knocked down the miR-181b-3p expression in CAFs, respectively.
exosome	36535010	hsa-mir-485	Pancreatic Carcinoma	3p by exosomes or some other vehicle might be a novel approach for PC treatment.
circulation_biomarker_diagnosis_up	36534156	hsa-mir-199a	Hirschsprung Disease	Plasma exosomal miR-199a-3p, a diagnostic marker, is crucial for the development of HSCR.
circulation_biomarker_prognosis_ns	36533956	hsa-mir-192	Esophageal Squamous Cell Carcinoma	Plasma miR5p could be used as a predictor of response to chemotherapy and prognosis in EC patients.
lncRNA target	36533778	hsa-mir-19a	Pre-Eclampsia	Our results elucidated that circ_0004904 reduced proliferation and cell motility of trophoblast cells via the miR-19a-3p-mediated GADD45A level elevation, indicating the involvement of circ_0004904/miR-19a-3p/GADD45A in PE progression.
target gene	36533720	hsa-mir-136	Esophageal Squamous Cell Carcinoma	CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma.
genetics_overexpression_promote	36533591	hsa-mir-125b-2	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
genetics_overexpression_promote	36533591	hsa-mir-214	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
genetics_overexpression_promote	36533591	hsa-mir-326	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
lncRNA target	36531954	hsa-mir-155	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
lncRNA target	36531954	hsa-mir-185	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
lncRNA target	36531954	hsa-mir-664a	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
circulation_biomarker_prognosis_ns	36531335	hsa-mir-340	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis.
circulation_biomarker_prognosis_ns	36531335	hsa-mir-450b	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis.
genetics_overexpression_suppress	36531016	hsa-mir-182	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
genetics_overexpression_suppress	36531016	hsa-mir-21	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
genetics_overexpression_suppress	36531016	hsa-mir-146b	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
circulation_biomarker_diagnosis_up	36530488	hsa-mir-27a	Liver Neoplasms	The results showed that miR-27a-3p is downregulated in blood, cell lines, and tissues of HCC patients compared to normal controls.
target gene	36530029	hsa-mir-29a	Liver Neoplasms	miR-29a-5p regulates the malignant biological process of liver cancer cells through ARID2 regulation of EMT.
lncRNA target	36530027	hsa-mir-7	Femur Head Necrosis	OBJECTIVES: To investigate whether circHIPK3 promotes bone microvascular activity and angiogenesis by targeting miR-7 and Kruppel-like factor 4 (KLF4)/vascular endothelial growth factor (VEGF) signaling in ONFH.
genetics_overexpression_suppress	36529892	hsa-mir-105	Carcinoma, Non-Small-Cell Lung	Overexpression of FAM138B can inhibit the expression level of miR
genetics_overexpression_promote	36529430	hsa-mir-138	Glioma	5p repressed the glioma malignant phenotype and MeCP2 overexpression reversed the inhibitory effect of miR
lncRNA target	36529281	hsa-mir-133a	Bloom Syndrome	SIGNIFICANCE: These findings suggest that MALAT1 positively regulates RhoA protein expression by inhibiting miR-133a-3p in BSM cells, and that its upregulation causes the RhoA upregulation, resulting in an augmented BSM contractility.
other	36529281	hsa-mir-133a	Asthma	In BSMs of the murine asthma model, upregulations of Malat1 and RhoA protein were observed concomitantly with downregulation of miR-133a-3p.
tissue_expression_ns	36529101	hsa-mir-34a	Anovulation	In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased.
tissue_expression_ns	36529101	hsa-mir-34a	Intestinal Atresia	In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased.
lncRNA target	36529069	hsa-mir-193a	Multiple Sclerosis	Therefore, miR-193a and its associated targets could serve potential prognostic, diagnostic, and therapeutic efficacy in MS patients.
genetics_knock down_promote	36528986	hsa-mir-136	Carcinoma, Hepatocellular	5p re-expression inhibited HCC cell growth and metastasis, which was abated by KIAA1522 overexpression.
lncRNA target	36528556	hsa-mir-520c	Squamous Cell Carcinoma of Head and Neck	The expression of HOXA-AS2 was found to be negatively associated with miR-520c-3p in OSCC tissues. CONCLUSION: HOXA-AS2 served an oncogene and promoted OSCC progression via the miR-520c-3p/SNX5 axis.
lncRNA target	36527891	hsa-mir-483	Leukemia, Monocytic, Acute	CONCLUSION: LncRNA NR2F1-AS1 affects the sensitivity of THP-1 cells to azacitidine resistance by regulating the miR3p/IGF1 axis, which may be a potential target for the treatment of acute monocytic leukemia.
lncRNA target	36527878	hsa-mir-140	Osteoarthritis, Knee	5p protects CPCs from fate changes via inhibiting Jagged1/Notch signaling in knee OA, providing attractive targets for OA therapeutics.
other	36527420	hsa-mir-183	Amyotrophic Lateral Sclerosis	5p and provides a molecular link between aberrant RNA processing and protein degradation, two major pillars in ALS pathogenesis.
lncRNA target	36527387	hsa-mir-139	Diabetes Mellitus	5p/HOXA9 might be an important therapeutic target in treating diabetic BMSCs and diabetic complications in the future.
other	36526091	hsa-mir-26b	Diabetic Retinopathy	3p, which was not observed in the other models.
other	36526091	hsa-mir-122	Diabetic Retinopathy	3p, which was not observed in the other models.
lncRNA target	36525235	hsa-mir-424	Carcinoma, Endometrioid	Rescue experiments further supported that lncRNA E27 inhibited proliferation, migration, invasion, and promoted apoptosis of endometrial cancer through miR-424/E2F6/E2F7 signaling axis. Conclusively, our findings revealed the role of lncRNA E27 in regulating the miR-424/E2F6/E2F7 signaling axis during EC progression, opening up new strategies for the treatment of endometrial cancer.
other	36524862	hsa-mir-144	Glaucoma	CONCLUSION: Circ_0047835 might contribute to fibrosis progression after glaucoma surgery by regulating the miR3p/SP1 axis.
epigenetics	36524545	hsa-mir-1258	Carcinoma, Hepatocellular	Systemic analysis and experimentally validation identified a ceRNA network (PVT1/miR-1258/DUSP13 axis) characterized by lipid regulatory potential, immune properties, and abnormal methylation states in patients with HCC and MVI. Furthermore, miR-1258 was an independent predictor for MVI in patients with HCC.
circRNA target	36524450	hsa-mir-199b	Carcinoma, Hepatocellular	MiR-199b-5p suppressed HCC progression by inhibiting STRN expression.
other	36524359	hsa-mir-3065	Carcinoma, Hepatocellular	ZFPM2AS1 regulates XRCC4 by sponging miR30655p to promote GS and HCC progression.
epigenetics	36524356	hsa-mir-378a	IMAGe syndrome	The SUFU gene promoter remained unmethylated in all tissue samples, while miR2143p and miR378a5p were downregulated in IUGR.
circulation_biomarker_diagnosis_ns	36524216	hsa-mir-193a	Keloid	The hsa_circ_0020792 and miR-193a-5p levels in keloid patient-Exo and healthy control-Exo, as well as in keloid fibroblasts and normal skin fibroblasts (NFs) were evaluated by RT-qPCR. CONCLUSION: Collectively, keloid patient plasma-derived exosomal hsa_circ_0020792 could promote the proliferation, migration, and fibrogenesis of NFs via modulating miR-193a-5p and activating TGF-beta1/Smad2/3 signaling.
exosome	36524211	hsa-mir-503	Glioma	Herein, the aim of the current investigation was to explore the functional role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-503 in glioma.
lncRNA target	36524095	hsa-mir-193b	Cardiomegaly	Here, the mechanism of action of the lncRNA terminal differentiation-induced non-coding RNA (TINCR), miR-193b-3p, and RAR-related orphan receptor A (RORA) mRNA was analyzed in an angiotensin (Ang) II-induced H9C2 cardiomyocyte hypertrophy model treated with QYDP. CONCLUSIONS: Administration of QYDP improves Ang II-induced H9C2 cardiomyocyte hypertrophy and increase cell proliferation rate through the TINCR/miR-193b-3p/RORA axis.
lncRNA target	36523634	hsa-mir-199a	Respiratory Distress Syndrome	The agomirs or antagomirs of MiR-199a-3p were injected into the caudal vein to figure out whether MiR-199a-3p could influence ARDS inflammation and lung injury, whereas the mimics or inhibitors of MiR-199a-3p, siRNA of Rab8a, or PAK4 inhibitor were transfected or applied to RAW264.7 cells to evaluate the mechanism of SAP release.
other	36523600	hsa-mir-92b	Polycystic Ovary Syndrome	BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction.
other	36523600	hsa-mir-20b	Polycystic Ovary Syndrome	BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction.
other	36523511	hsa-mir-149	Carcinoma, Renal Cell	We also identified the lncRNA UBA6-AS1/miR5p/MMP9 regulatory axis for the progression of ccRCC.
genetics_overexpression_suppress	36523479	hsa-mir-4472	Breast Neoplasms	miR-4472 levels were reduced, and repulsive guidance molecule A (RGMA) mRNA or protein levels were increased after overexpression of RP11-551L14.4 in the breast cancer cells.
circulation_biomarker_diagnosis_ns	36523365	hsa-mir-126	Myocardial Infarction, Acute	CONCLUSION: Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events.
other	36523292	hsa-mir-1	Glioma	The present study was to analyze the mechanism of microRNA (miR)-1 in regulating the proliferation and invasion of glioma cells.
genetics_overexpression_promote	36523183	hsa-mir-362	Osteoarthritis	Additionally, overexpressed miR
genetics_knock down_promote	36523170	hsa-mir-760	Lung Neoplasms	RAB3D was a target of miR-760, and its knockdown reversed the promotion effect of miR-760 inhibitor on the progression of curcumin-treated LC cells.
transcription factor target	36523152	hsa-mir-182	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: CXCR7 protects against cerebral I/R injury, possibly via the miR-182/TCF7L2/Hippo pathway.
circulation_biomarker_diagnosis_ns	36523143	hsa-mir-197	Atherosclerosis	3p was decreased in the serum of AS patients compared to healthy donors.
circulation_biomarker_diagnosis_up	36522766	hsa-mir-149	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer.
circulation_biomarker_diagnosis_up	36522766	hsa-mir-4769	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer.
exosome	36522730	hsa-mir-21	Colonic Neoplasms	CONCLUSIONS: Our results implicated a reciprocal communication between colon cancer cells and Schwan cells that promoted the proliferation and metastasis of colon cancer, and identified NGF and exosomal miR
other	36522710	hsa-mir-126	Pulmonary Disease, Chronic Obstructive	Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH.
other	36522710	hsa-mir-126	Hypertension, Pulmonary	Since CS decreases miR126 in microvascular lung endothelial cells, we set out to characterize the remodeling by pulmonary vascular size in COPD-PH and its relationship with miR126 in COPD and COPD-PH lungs. Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH.
lncRNA target	36522683	hsa-mir-449b	Esophageal Squamous Cell Carcinoma	CONCLUSIONS: IGF2BP2 mediated circRUNX1 functions as an oncogenic factor to facilitate ESCC progression through the miR-449b-5p/FOXP3 axis, implying that circRUNX1 has the potential to be a promising diagnostic marker and therapeutic target for ESCC patients.
lncRNA target	36522638	hsa-mir-26a	Parvoviridae Infections	parvum as well as treated with miR-26a-mimic, miR-30a-mimic, miR-26a-mimic or miR-30a-inhibitor post C.
genetics_overexpression_suppress	36522613	hsa-mir-495	Melanoma	3p, and CREB1 overexpression enhanced melanoma cell viability by inhibiting miR
genetics_overexpression_promote	36522479	hsa-mir-181b	Breast Neoplasms	Overexpression of miR-181b-5p downregulated p53/p21 levels and inhibited doxorubicin-induced G1 arrest and senescence by suppressing BCLAF1 expression in vitro.
lncRNA target	36522211	hsa-mir-18b	Pulpitis	DUXAP8 upregulation and miR-18b-5p downregulation were found in pulpitis. CONCLUSIONS: Results demonstrated that LPS-induced cell injury in pulpitis was promoted by DUXAP8 through mediating miR-18b-5p/HIF3A axis.
exosome	36521318	hsa-mir-543	adhesions of uterus	Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions.
exosome	36521318	hsa-mir-543	Uterine Diseases	Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions. DISCUSSION: Collectively, UCMSCs-derived exosomal miR-543 was able to prevent endometrial fibrosis both in vitro and in vivo via downregulating N-cadherin.
genetics_knock down_suppress	36520963	hsa-mir-1	Nasopharyngeal Carcinoma	Knockdown of lncRNA SNHG16 attenuates radioresistance of nasopharyngeal carcinoma cells by miR
exosome	36520505	hsa-mir-143	Periodontitis	In conclusion, these results demonstrate that inflammatory PDLSCs facilitate M1 macrophage polarization through the exosomal miR
target gene	36520299	hsa-mir-2053	Colitis, Ulcerative	Collectively, rs6214 increased UC susceptibility and suppresses IGF-1 expression by enhancing miR-2053 binding.
lncRNA target	36520091	hsa-mir-335	Bone Diseases	In conclusion, melatonin facilitates osteogenesis in bone defect healing by enhancing miR5p expression and inhibiting the TNFalpha/NF-kappaB pathway.
circRNA target	36519785	hsa-mir-363	Prostatic Neoplasms	We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management.
circRNA target	36519785	hsa-mir-708	Prostatic Neoplasms	We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management.
lncRNA target	36519522	hsa-mir-874	Colorectal Neoplasms	CONCLUSION: Circ-CCS expedited CRC through miR
circulation_biomarker_diagnosis_up	36519433	hsa-mir-155	Pre-Eclampsia	RESULTS: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels.
genetics_knock down_promote	36519409	hsa-mir-124	Gastric   Cancer	3p or increasing ZNF655 could counteract the effects of LINC01210 knockdown on GC cell development.
other	36519254	hsa-mir-519a	Carcinoma, Hepatocellular	CONCLUSION: These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR-519a-5p/ARHGAP29 axis in HCC development.
circulation_biomarker_diagnosis_ns	36519116	hsa-mir-93	Tuberculosis	RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB.
circulation_biomarker_diagnosis_ns	36519116	hsa-mir-16	Tuberculosis	RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB.
genetics_GWAS	36518850	hsa-mir-122	Carcinoma, Hepatocellular	The aim of this study was to evaluate phenotypic and genetic heterogeneity of circulating epithelial cells (CECs) based on asialoglycoprotein receptor 1 (ASGR1) and miR
genetics_knock down_promote	36518817	hsa-mir-101	Pulmonary Disease, Chronic Obstructive	3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell BACKGROUND: Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function.
circulation_biomarker_diagnosis_ns	36518749	hsa-mir-138	Scleroderma, Systemic	Accordingly, the gene expression of miR-138 was assessed to find any alterations in the whole blood of the SSc patients.
lncRNA target	36518289	hsa-mir-491	Colorectal Neoplasms	3p expression promotes CRC progression through regulating uMtCK.
circulation_biomarker_diagnosis_ns	36517751	hsa-mir-184	Cardiotoxicity	We also found that distribution of particular miRNAs between of plasma and EVs (proportion between compartments) e.g., miR-184 in ALL, is altered, suggesting changes within secretory and miRNA sorting mechanisms.
circulation_biomarker_diagnosis_ns	36517751	hsa-mir-144	Cardiotoxicity	Moreover, vesicular miR3p correlates with the highest number of echocardiographic parameters and is differentially expressed in the circulation of patients with dilated cardiomyopathy.
genetics_knock down_promote	36517015	hsa-mir-423	Cardiomegaly	5p knockdown exerts its protective effects on Ang II-induced cardiomyocyte hypertrophy in HCMs via modulating SUPT6H expression.
lncRNA target	36515797	hsa-mir-671	late onset Parkinson's disease	UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD.
genetics_knock down_suppress	36515797	hsa-mir-671	Inflammation	KPNA4 overexpression offset the inhibitory influence of miR
lncRNA target	36515797	hsa-mir-671	Aicardi-Goutieres syndrome 5	UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD.
exosome	36515680	hsa-mir-195a	Acute Kidney Injury	Furthermore, in vitro inhibition of miR-195a-5p alleviated the effect of Exos(AKI) induced mitochondrial dysfunction and cell injury.
other	36515567	hsa-mir-382	Squamous Cell Carcinoma of Head and Neck	Our data demonstrate that circ_0000052 is oncogenic, and the circ_0000052/miR3p/PD-L1 axis is critical in HNSCC progression.
genetics_overexpression_suppress	36515277	hsa-mir-1290	Stomach Neoplasms	MiR-1290 was predicted as a target of circ_0026344 and miR-1290 overexpression attenuated the anti-tumor effect of circ_0026344 on GC cells. CONCLUSION: In conclusion, circ_0026344 inhibited GC cell proliferation via the miR-1290/FBP2 axis, which might provide a new therapeutic target for GC patients.
exosome	36514348	hsa-mir-222	Pre-Eclampsia	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways.
exosome	36514348	hsa-mir-222	Hypertension, Pregnancy-Induced	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways.
exosome	36514348	hsa-mir-155	Pre-Eclampsia	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE).
exosome	36514348	hsa-mir-155	Hypertension, Pregnancy-Induced	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE).
other	36514216	hsa-mir-486	Pulmonary Disease, Chronic Obstructive	5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD.
genetics_overexpression_promote	36514078	hsa-mir-709	Spinal Cord Injuries	Moreover, experiments confirmed that Treg cells targeted the NKAP via exosomal miR-709 to reduce microglia pyroptosis and promote motor function recovery after SCI. More importantly, The miR-709 overexpressed exosomes we constructed significantly reduced the inflammatory response and improved motor recovery after spinal cord injury.
other	36513954	hsa-mir-214	Breast Neoplasms	5p/ROCK1 pathway, which might provide a new perspective to investigate the development process of BC.
target gene	36513872	hsa-mir-196a	Stomach Neoplasms	miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2.
genetics_overexpression_promote	36513585	hsa-mir-95	Triple Negative Breast Neoplasms	CONCLUSION: Overexpression of circ_0001777 decreased proliferation, migration, and invasion of TNBC cells by regulating the miR
circulation_biomarker_diagnosis_ns	36513264	hsa-mir-21	renal fibrosis	RESULTS: A positive correlation was found between plasma miR-21 levels and RF scores of rats after UUO surgery at Days 3, 7, 14 and 21.
other	36513253	hsa-mir-144	Non-alcoholic Fatty Liver Disease	5p was reduced in HFD-managed models and patients with NAFLD.
transcription factor target	36513242	hsa-mir-429	Kidney Diseases	These findings suggest that endosulfan can lead to kidney cell injury by modulating ACE2 through up-regulating miR-429, providing new evidence for the pathogenesis of CKDu.
genetics_overexpression_suppress	36512648	hsa-mir-655	Thyroid Cancer, Papillary	Overexpression of miR
lncRNA target	36512502	hsa-mir-122	Hepatitis C	Our study identifies PLK1-ELAVL1/HuR-miR-122 signaling as a regulatory axis that is critical for HCV proliferation, and suggests that a therapeutic approach targeting this host cell signaling pathway could be useful for treating HCV and HCV-associated diseases.
lncRNA target	36512324	hsa-mir-532	Carcinoma, Ovarian Epithelial	Furthermore, circATP2B4 induced macrophage M2 polarization by regulating the miR3p/SREBF1/PI3Kalpha/AKT axis, thereby leading to immunosuppression and ovarian cancer metastasis.
other	36511578	hsa-mir-155	Lung Neoplasms	In the second group, miR5p allows to predict lung cancers and colon cancers.
other	36511578	hsa-mir-155	Colonic Neoplasms	In the second group, miR5p allows to predict lung cancers and colon cancers.
other	36511422	hsa-mir-590	Myocardial Reperfusion Injury	3p regulates the TLR4/MyD88/NF-kappaB pathway by interacting with HMGB1 to protect against OGD/R-induced I/R injury.
other	36511396	hsa-mir-7	Alzheimer Disease	This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia.
circulation_biomarker_diagnosis_up	36510992	hsa-mir-1246	Colorectal Neoplasms	CONCLUSION: We confirmed the capability of circulating serum miR-1229 and miR-1246 as novel diagnostic biomarkers for CRC.
transcription factor target	36510830	hsa-mir-216b	Angelman Syndrome	The function of miR-216b-5p in AS remains unknown. miR-216b-5p alleviates the dysfunction of VSMCs and HUVECs caused by ox-LDL via repressing IGF2, and exerts protective functions to block the development of AS.
lncRNA target	36510610	hsa-mir-2116	Retinal Diseases	CONCLUSION: Rg1 inhibits HG-induced proliferation, migration, angiogenesis, and VEGF expression in retinal endothelial cells through the lncRNA SNG7/miR5p/SIRT3 axis.
genetics_overexpression_promote	36510495	hsa-mir-1	Lupus Erythematosus, Systemic	5p was downregulated and negatively correlated with the overexpression of SLC15A4 in PBMCs of SLE patients.
lncRNA target	36510038	hsa-mir-29c	Pancreatic Carcinoma	RESULTS: Through differential analysis, five pancreatic cancer-related miRNAs (hsa-miR-29c, hsa-miR-107, hsa-miR
lncRNA target	36509232	hsa-mir-101	Osteosarcoma	In addition, our study proved that TYMSOS promotes the malignancy of OS via elevating NETO2 expression as miR
other	36508822	hsa-mir-146b	Immune System Diseases	The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation.
other	36508822	hsa-mir-146b	Pneumonia	The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation.
genetics_knock down_suppress	36508789	hsa-mir-125a	Pulmonary Fibrosis	MiR-125a-5p anta-miR treatment contributes to the maintenance of Th1/Th2 balance during the progression of pulmonary fibrosis. Our findings indicated that knockdown miR-125a-5p could regulate T lymphocyte subsets and significantly reduce pulmonary fibrosis by targeting TRAF6.
lncRNA target	36508480	hsa-mir-199a	High Grade Ovarian Neoplasms	After treatment with CGA, cells derived from ovarian cancer cells were deregulated partially via the miR199a5p/DDR1 axis, significantly affecting tumour suppression. DDR1 has been identified as a direct target of miR199a5p in these ovarian cancer cells.
genetics_overexpression_promote	36508388	hsa-mir-1298	Uterine Cervical Neoplasms	While silencing of ONECUT2 could suppress the proliferation of cervical cancer cells, its overexpression could nullify the tumor-suppressive effects of miR
lncRNA target	36508036	hsa-mir-370	Endometriosis	CONCLUSION: IGF2-AS promotes endometriotic cell growth via regulating IGF2/miR3p axis and further activating PI3K/AKT/mTOR signaling pathway.
exosome	36506936	hsa-mir-425	Breast Neoplasms	Transfection of exosomes is obtained from BC cells, and miR
circulation_biomarker_diagnosis_up	36506422	hsa-mir-200a	Depressive Disorder, Major	Relative serum levels of miR-30a, miR-30e, and miR-200a, normalized to U6, were measured by quantitative real-time PCR in MDD inpatients with (MDD/SI, N = 19) and without (MDD, N = 31) acute suicide risk.
lncRNA target	36506327	hsa-mir-17	Varicose Veins	Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1.
lncRNA target	36506327	hsa-mir-21	Varicose Veins	Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1.
transcription factor target	36506063	hsa-mir-26b	Diabetes Mellitus, Type 1	Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.
transcription factor target	36506063	hsa-mir-21	Diabetes Mellitus, Type 1	Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.
transcription factor target	36506055	hsa-mir-92b	Alstrom Syndrome	Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups.
transcription factor target	36506055	hsa-mir-92b	Bardet-Biedl Syndrome 11	Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups.
circulation_biomarker_diagnosis_up	36505330	hsa-mir-355	Mucocutaneous Lymph Node Syndrome	CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease.
circulation_biomarker_diagnosis_up	36505330	hsa-mir-2911	Mucocutaneous Lymph Node Syndrome	CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease.
circulation_biomarker_prognosis_ns	36505313	hsa-mir-127	Sepsis	The areas under the ROC curve (AUC) of serum miR-127, SOFA score, and APACHE II score for predicting prognosis of sepsis patients were 0.748 (0.674-0.823), 0.810 (0.742-0.878) and 0.864 (0.811-0.916), respectively.
target gene	36505312	hsa-mir-370	Lung Neoplasms	miR-370 impacts the biological behavior of lung cancer cells by targeting the SMAD1 signaling pathway.
genetics_knock down_promote	36505286	hsa-mir-216b	Colorectal Neoplasms	miR-216b overexpression suppressed tumor growth, metastasis and expressions of CPEB4, CD206 and IL-10 in CRC xenograft models.
lncRNA target	36505084	hsa-mir-31	Leukemia	HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs.
lncRNA target	36505084	hsa-mir-193	Leukemia	HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs.
circulation_biomarker_diagnosis_up	36504565	hsa-mir-18a	Stomach Neoplasms	CONCLUSION: A panel of circulating miR18a/21/125b could be suggested as a potential biomarker for the early detection of GC.
lncRNA target	36504472	hsa-mir-146a	Diabetes Mellitus	Furthermore, the downregulation of mir146a, as an inflammatory microRNA interacting with TLR4, showed another pathway, through which tropisetron improved diabetes-induced testicular injuries.
lncRNA target	36504384	hsa-mir-371a	Necrosis	BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT.
lncRNA target	36504384	hsa-mir-371a	Teratoma	BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT.
exosome	36504133	hsa-mir-21	Hyperglycemia	This study aimed to investigate the effects of AS-IV-mediated EPCs exosomal miR-21 (EPC-exos-miR-21) on high glucose (HG) damaged endothelial cells.
circulation_biomarker_diagnosis_up	36504065	hsa-mir-342	Arthritis, Rheumatoid	3p in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA) and its effect on inflammatory response and migration of synovial fibroblasts in RA (RA-FLS).
genetics_knock down_suppress	36504056	hsa-mir-4772	Ovarian Neoplasms	Survival analysis was carried out to identify the survival-related hub genes, and the results were validated using the data of 399 patients with ovarian cancer from GEO database and the sequencing results of SKOV3 cells transfected with miR-4772 mimics or inhibitor.
genetics_overexpression_promote	36504050	hsa-mir-607	Carcinoma, Hepatocellular	Overexpression of miR-607 inhibits HCC growth and metastasis possibly by down- regulating TRPC5, which causes Akt signaling inactivation.
other	36503407	hsa-mir-520h	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-628	Pregnancy Complications	5p.
other	36503407	hsa-mir-191	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-125b	Pregnancy Complications	5p.
other	36503407	hsa-mir-518b	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
lncRNA target	36503346	hsa-mir-8082	Osteoarthritis	In our study, patients with OA showed downregulation of NAV2-AS5, upregulation of miR-8082, and downregulation of TNFAIP3 interacting protein 2 (TNIP2). In conclusion, these findings indicate that NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in OA, which provides a new theoretical basis for OA therapy.
lncRNA target	36503162	hsa-mir-581	Prostatic Neoplasms	In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/beta-catenin pathways.
tissue_expression_up	36502883	hsa-mir-146a	Triple Negative Breast Neoplasms	The analysis of the external validation cohorts corroborated the unfavorable nature of miR-146a repression regarding patients&#x27; survival and, strikingly, unveiled the ability of miR-146a to predict TNBC metastasis.
target gene	36502446	hsa-mir-27b	Lymphoma, Large B-Cell, Diffuse	miR-27b can inhibit the proliferation and invasiveness of DLBCL cells and promote the apoptosis of the cells by targeting MET/PI3K/AKT pathway.
transcription factor target	36499744	hsa-mir-122	Fibrosis, Renal	5p inhibitor suppressed renal fibrosis and downregulated COL1A2 and FN1.
genetics_overexpression_suppress	36499676	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	5p by BMI1 overexpression could lead to the enhanced expression of Sp1 to induce the EMT process in pemetrexed-resistant NSCLC cells.
other	36499626	hsa-mir-200c	Ovarian Neoplasms	Moreover, miR-200c increased the sensitivity of ovarian cancer cells to cisplatin treatment by regulating mortalin levels. The combination of cisplatin and miR-200c significantly enhanced the therapeutic effects on ovarian cancer in vivo, suggesting that miR-200c may serve as a potential therapeutic agent for ovarian cancer.
lncRNA target	36499626	hsa-mir-200b	Ovarian Neoplasms	In this study, microRNA (miR)-200b/c downregulated mortalin expression and inhibited the proliferation and migration of the paired cisplatin-sensitive (A2780S) and cisplatin-resistant (A2780CP) epithelial ovarian cancer cell lines.
other	36499586	hsa-mir-122	Colonic Neoplasms	In conclusions, the study has explored the role of miR-122 in CRC and has identified a closely related group of genes influencing the prognosis of CRC in multiple ways.
other	36499552	hsa-mir-342	Heart Failure	3p) revealed pathways related to HF pathogenesis.
other	36499552	hsa-mir-125a	Heart Failure	3p) revealed pathways related to HF pathogenesis.
other	36499552	hsa-let-7a	Heart Failure	3p) revealed pathways related to HF pathogenesis.
transcription factor target	36499501	hsa-mir-186	Urinary Bladder Neoplasms	5p were confirmed as interfering with the stability of the mRNAs of DAP10, CD96, and the perforin gene in NK cells and may be potential targets used in the therapy for BC.
other	36499397	hsa-mir-200c	FG syndrome	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
other	36499397	hsa-mir-200c	Hematologic Diseases	We investigated the expression of miR-200c in urine from patients with different renal diseases as a potential candidate involved in podocytopathies.
other	36499397	hsa-mir-200c	Glomerulonephritis, Membranous	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
other	36499397	hsa-mir-200c	Nephrosis, Lipoid	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
epigenetics	36499350	hsa-mir-124-2	Acquired Immunodeficiency Syndrome	Our bisulfite-converted genomic DNA sequencing also revealed significant promoter DNA methylation in the pri-miR
genetics_overexpression_suppress	36499299	hsa-mir-4732	Premature Birth	Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR5p was significantly overexpressed.
other	36499299	hsa-mir-125a	Premature Birth	Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95% CI: 0.814-0.972; p < 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk.
other	36499183	hsa-mir-18a	Prostatic Neoplasms	In conclusion, deregulation of the miR-18a-5p/P4HB network can contribute to the developmental origins of prostate cancer in maternally malnourished offspring, highlighting the need for improving maternal healthcare during critical windows of vulnerability early in life.
other	36499129	hsa-mir-21	Breast Neoplasms	miR-21 is upregulated in breast cancer that has been linked to drug resistance and carcinogenic processes.
other	36499093	hsa-mir-26a	Extramedullary Multiple Myeloma	Further, miR-26a-5p and miR-30e-5p were found to be significantly down-regulated in EMD compared to MM.
other	36499048	hsa-mir-222	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-140	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-15a	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-124	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-106b	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499023	hsa-mir-369	Diabetes Mellitus, Type 2	3p).
other	36499023	hsa-mir-369	Hypoglycemia	3p).
genetics_overexpression_promote	36498905	hsa-mir-29c	Pulmonary Fibrosis	miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-.
genetics_overexpression_promote	36498905	hsa-mir-29c	Antisynthetase syndrome	miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-.
circRNA target	36497344	hsa-mir-934	Breast Neoplasms	Altogether, these findings reveal that circRNF10 functions as a novel anti-oncogene in BC via sponging miR-934 and suppressing the PI3K/Akt/MICA pathway.
exosome	36497115	hsa-mir-20a	Carcinoma, Hepatocellular	In summary, LIMA1 is a tumour suppressor that inhibits the Wnt/beta-catenin signalling pathway and is downregulated by CAF-derived exosomes carrying oncogenic miR-20a-5p in HCC.
circulation_biomarker_diagnosis_ns	36497090	hsa-mir-342	Alzheimer Disease	5p was dysregulated in human circulating sEVs from AD patients; sEV transfer of miR
circulation_biomarker_diagnosis_ns	36497052	hsa-mir-125a	Moyamoya Disease	CircZXDC sponges miR-125a-3p to increase ABCC6 expression, which induces ERS (endoplasmic reticulum stress), and subsequently regulates VSMC transdifferentiation from the contractive phenotype to the synthetic phenotype, contributing to the intima thickness of MMD vessels. Our findings provide insight into the pathophysiological mechanisms of MMD and indicate that the circZXDC-miR-125a-3p-ABCC6 axis plays a pivotal role in the progression of MMD.
other	36497036	hsa-mir-1274a	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1207	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1268	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1274b	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36496421	hsa-mir-195	Adenocarcinoma of Lung	We also demonstrate that D-limonene-miRSREBP1/FASN axis is a potential preventive intervention for mediating the progression and development of LUAD induced by PM(2.5) exposure.
other	36496032	hsa-mir-342	Ischemic Stroke	SIGNIFICANCE: This study suggests that PEG11as regulates neuronal apoptosis by miR5p/PFN1 axis, which may contribute to our understanding of pathogenesis and provide a potential therapeutic option for cerebral I/R.
genetics_knock down_promote	36495604	hsa-mir-652	Carcinoma, Hepatocellular	3p, and the knockdown of TNRC6A restored repressed EMT and HCC metastasis caused by the inhibition of miR
other	36495516	hsa-mir-29a	Chronic Kidney   Disease	Then, Mir-29a-5p, sclerostin and fetuin-A are abnormally expressed in chronic kidney disease.
other	36495516	hsa-mir-29a	Vascular Calcification	Results showed that compared with the control group, the expression of mir-29a-5p and sclerostin in the study group was higher, and the expression of fetuin-A was lower, the difference was statistically significant (P < 0.05); The expression of mir-29a-5p, sclerostin and fetuin-A in calcified group was higher than that in non-calcified group, and the expression of fetuin-A was lower (P < 0.05); Mir-29a-5p and sclerostin showed positive correlation (r=6.776, P=0.011); The expression of mir-29a-5p and fetuin-A showed negative correlation (r=-5.326, P=0.001); The expression of mir-29a-5p and sclerostin showed negative correlation (r=-9.677, P=0.001); Mir-29a-5p and sclerostin were positively correlated with vascular calcification (r=0.695, P=0.001; r=0.715, P=0.001), and fetuin-A was positively correlated with vascular calcification (r = -0.953, P = 0.001).
lncRNA target	36495514	hsa-mir-144	Carcinoma, Hepatocellular	The liver tissue of miR-144 is low, the level of gene expression CCNB1 protein expression level is higher, the expression level in liver cancer cells directly influences the curative effect of hepatocellular carcinoma patients, the miR-144 gene can negative regulation CCNB1 protein, through this kind of negative adjustment to the biological behavior of liver cancer cells have a profound impact.
lncRNA target	36495510	hsa-mir-382	Colorectal Neoplasms	It is concluded that Circ_0022340 promoted colorectal cancer progression via recruiting HNRNPC to stabilize EBF1 mRNA and thereby activated SYT7 or miR5p/ELK1 axis, which might provide a novel target for CRC treatment.
transcription factor target	36495508	hsa-mir-29a	Renal Insufficiency, Chronic	Thus, miR-29a-5p/GSAP might be a potential target for the treatment of vascular calcification.
other	36495505	hsa-mir-1	Hypertension	The results showed that the apoptosis rate of myocardial cells in the miRNA-1 group decreased (0.710 /- 0.009661)% vs (1.066667 /- 0.02603)% compared with that in the spontaneous hypertension control group (P < 0.001).
other	36495504	hsa-mir-29a	Kidney Failure, Chronic	Mir-129 and Mir-29a-5p showed high expression in the patients with end-stage renal disease, and they also increased with the occurrence of vascular calcification, and they showed a positive correlation in the vascular calcification of end-stage renal disease.
circulation_biomarker_diagnosis_up	36495497	hsa-mir-193a	Aortic Aneurysm, Thoracic	In the current study, we discovered that miR-193a-5p was expressed at low levels in the blood of TAA patients.
epigenetics	36495416	hsa-mir-217	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	DNMT3A could be the molecular target of miR-217 by regulating PER2 gene methylation and getting involved with the occurrence and development of CML.
other	36495003	hsa-mir-155	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-203	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-146a	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-142	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-146b	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
target gene	36494581	hsa-mir-219	Ovarian Neoplasms	miR-219-5p attenuates cisplatin resistance of ovarian cancer by inactivating Wnt/β-catenin signaling and autophagy via targeting HMGA2.
lncRNA target	36494481	hsa-mir-34a	Carcinoma, Hepatocellular	Mechanistic studies suggest that ALDOA is a direct target of miR-34a-5p, which can inhibit glycolysis in hepatocellular carcinoma cells by targeting the 3'UTR of ALDOA.
other	36494341	hsa-mir-199a	Carcinoma, Renal Cell	Mechanistically, circPLIN2 not only increased the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, which ultimately resulted in ccRCC tumorigenesis and progression.
exosome	36494333	hsa-mir-197	Adenocarcinoma of Lung	In conclusion, LUAD cells-derived exosomal miR
other	36494326	hsa-mir-21	Crohn Disease	In conclusion, the level of miR-21 decreased in CD, resulting in an upregulated PI3K-Akt-mTOR signaling pathway, compromised immune tolerance, and elevated inflammation.
exosome	36494212	hsa-mir-17	Virus Diseases	EVs participated in TLR3-dependent antiviral immunity, protecting the host from viral infections through both EV-mediated functional delivery of miR-17 and direct virion neutralization after binding to virus ligands via surface receptors, including LDLR and ICAM-1.
exosome	36493861	hsa-mir-146a	Peripheral Nerve Injuries	CONCLUSION: Our study confirmed that miR-146a-5p was significantly decreased in SC-Exos under the ischemia-hypoxic microenvironment of the injury site after PNI, which mediated its shift from promoting macrophage M2 polarization (anti-inflammation) to promoting M1 polarization (pro-inflammation), thereby limiting axonal regeneration and functional recovery.
genetics_knock down_promote	36493845	hsa-mir-493	Esophageal Squamous Cell Carcinoma	Moreover, our multiple gain-and loss-of-functional experiments proved that a combination of miR
genetics_overexpression_promote	36484970	hsa-mir-19b	Glioma	The glioma patients exhibited overexpressed miR-19b-3p and poorly-expressed SOCS3.
lncRNA target	36484486	hsa-mir-515	Stomach Neoplasms	CircPDSS1 conferred DDP resistance through the miR
circulation_biomarker_diagnosis_down	36484399	hsa-mir-340	Duane Retraction Syndrome	In the blood of DR patients and the DR model, lncRNA SNHG1 was increased and miR
genetics_knock down_promote	36484173	hsa-mir-873	Esophageal Squamous Cell Carcinoma	CONCLUSION: CircLPAR3 knockdown suppressed ESCC cell growth, metastasis, and Warburg effect by miR
target gene	36484007	hsa-mir-29c	Stomach Neoplasms	miR-29c inhibits metastasis of gastric cancer cells by targeting VEGFA.
other	36483920	hsa-mir-23b	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-155	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-146a	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-124	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-195	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-24	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
exosome	36483681	hsa-mir-134	Squamous Cell Carcinoma of Head and Neck	We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). This study hypothesize that OSCC-CSC-derived small extracellular vesicles (OSCC-CSC-sEVs) transfer a ceRNA of miR-134 and consequently promote M2 macrophage polarization by targeting LAMC2 via the PI3K/AKT pathway through in vitro and in vivo experiment methods.
other	36482859	hsa-mir-125	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-21	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-200b	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-21	Periodontitis	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05).
other	36482859	hsa-mir-7a	Periodontitis	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05).
other	36482859	hsa-mir-7a	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-100	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
lncRNA target	36482855	hsa-mir-372	Epilepsy	CONCLUSION: Our study suggests that targeting HOXA-AS2 could alleviate cellular damages in the epileptic model by regulating miR3p/STAT3 axis.
other	36482742	hsa-mir-1290	Carcinoma, Non-Small-Cell Lung	In summary, circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis.
circulation_biomarker_diagnosis_up	36482739	hsa-mir-455	Colorectal Neoplasms	3p expression was both higher in the serum and tumor tissues of CRC patients.
other	36482542	hsa-mir-140	Squamous Intraepithelial Lesions of the Cervix	CONCLUSIONS: The differential expression and potential effects of the lncRNA BACH1-IT1/miR5p/VEGFA axis, key genes, VEGFA and FOS, and MAPK signaling in CIN were clarified, and the occurrence and potential effects of CIN were further clarified.
lncRNA target	36482494	hsa-mir-142	Ovarian Neoplasms	Overall, our data demonstrate that hsa_circ_0000119 facilitated ovarian cancer development through increasing CDH13 expression via promoting DNMT1 expression by sponging miR
genetics_knock down_promote	36482354	hsa-mir-503	Pancreatic Carcinoma	5p down-regulation and ANLN up-regulation reversed the effects of LINC00460 knockdown on inhibiting the proliferation, migration and invasion, and on promoting the apoptosis, G0/G1 phase arrest, and the sensitivity of PC cells to the cytotoxicity of CD8(+) T cells.
transcription factor target	36482325	hsa-mir-431	Carcinoma, Hepatocellular	Expression of HHIP, a possible miR5p target gene, was significantly downregulated in HCC cells.
circulation_biomarker_diagnosis_ns	36482069	hsa-mir-34a	Hepatitis B, Chronic	Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum.
circulation_biomarker_diagnosis_ns	36482069	hsa-mir-34a	Fibrosis	miR-34a-5p inhibitor undo protective regulation of sh-CCAT2 in liver fibrosis. Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum.
genetics_overexpression_promote	36481751	hsa-mir-185	Hyperlipidemias	3p overexpression or MAML1 silencing reduced levels of serum lipids, mitigated oxidative stress and inflammatory response, relieved lipid accumulation and pathological morphology in liver tissues in hyperlipidemia rats; while up-regulated MAML1 reversed the effects of augmented miR
transcription factor target	36481664	hsa-mir-29a	COVID-19	Intriguingly, hsa-miR-29a-3p significantly downregulated in severe COVID-19 was predicted to bind the 3'-untranslated regions of both IL17RA and THBS1 mRNAs. These findings strongly suggest that dysregulated expression of THBS1, IL17RA, and hsa-miR-29a-3p involves severe COVID-19.
genetics_knock down_promote	36481629	hsa-mir-1	Ovarian Neoplasms	3p mimics on enhancing the sensitivity of human ovarian cancer cells to Erastin-induced or RSL3-induced ferroptosis was abrogated by overexpression of FZD7(P<0.05 or P<0.01).
other	36481589	hsa-mir-27a	Infertility, Female	In summary, our findings reveal that miR-27a-3p is a novel regulator of E2 synthesis and may predict litter size of Hu sheep, providing insight into mechanisms underlying granulosa cell function and female fertility.
lncRNA target	36481473	hsa-mir-936	Ovarian Neoplasms	These data suggested that circ_0021573 might promote the malignant phenotypes of ovarian cancer cells by functioning as a ceRNA for miR-936 to induce CUL4B, which provided a promising target for the prevention and inhibition of ovarian cancer.
exosome	36481205	hsa-mir-27a	Arthritis, Rheumatoid	Summarily, exosomal lncRNA TRAFD1-4:1 derived from RA-FLSs suppressed chondrocyte proliferation and migration through degrading CECM by upregulating CXCL1 as a sponge of miR-27a-3p.
other	36480308	hsa-mir-21	Prostatic Neoplasms	Herein, a solution-gated graphene transistor (SGGT) biosensor for the ultrasensitive and rapid quantification detection of the early prostate cancer-relevant biomarker, miRNA-21 is reported.
genetics_overexpression_promote	36479734	hsa-mir-199b	Carcinoma, Hepatocellular	Moreover, miR-199b-5p could target OTX1, and OTX1 overexpression reverted the repressive impact of miR-199b-5p mimic on the malignancy of HCC cells. In conclusion circKIAA1429 might promote HCC progression via regulating miR-199b-5p/OTX1 axis.
lncRNA target	36479657	hsa-mir-646	Pancreatic Carcinoma	Delivery of circ_0086375 by nanoparticles suppresses the tumorigenicity of pancreatic cancer by miR-646/SLC4A4 axis, suggesting a new potential target for future pancreatic cancer treatment.
lncRNA target	36479622	hsa-mir-101	Glioma	Therefore, targeting SPRY4-IT1/miR
circulation_biomarker_prognosis_up	36478451	hsa-mir-15b	Prostatic Neoplasms	In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively).
circulation_biomarker_prognosis_up	36478451	hsa-mir-106b	Prostatic Neoplasms	In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively).
other	36478437	hsa-mir-23a	Infertility, Female	Overall, our findings suggest that the SNVs g.-283G>C and g.-271C>T in the miR-23a promoter are causal variants affecting GC apoptosis and miR-23a may be a potential small-molecule nonhormonal drug for regulating female fertility.
lncRNA target	36478207	hsa-mir-494	Pneumonia, Mycoplasma	CONCLUSION: Overall, by suppressing HTR8/SVneo cell growth and migration via the miR3p/PTEN axis and other mechanisms, LINC00534 offers new insight into PE pathogenesis.
other	36477577	hsa-mir-186	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-144	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-206	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-203a	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-205	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
lncRNA target	36477451	hsa-mir-148	Carcinoma, Renal Cell	CONCLUSION: Curcumin can inhibit the proliferation of renal cell carcinoma by regulating the miR-148/ ADAMTS18 axis through the suppression of autophagy in vitro and in vivo. There may exist a positive feedback loop between miR-148 and ADAMTS18 gene in RCC.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	beta-Thalassemia	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Anemia, Iron-Deficiency	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Anemia, Aplastic	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Myelodysplastic Syndromes	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
genetics_overexpression_promote	36476884	hsa-mir-29a	Leukemia	miR-29a-3p could target and regulate the expression of HDGF, while overexpression of HDGF reversed the inhibitory effect of miR-29a-3p overexpression on the proliferation and promotion effect on the apoptosis of leukemia cells E6-1.
genetics_overexpression_promote	36476884	hsa-mir-29a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Overexpression of miR-29a-3p can inhibit the proliferation and promote the apoptosis of ALL cells E6-1, and its mechanism may be related to the regulation of HDGF expression.
other	36476775	hsa-mir-146a	Diabetes Mellitus, Type 2	The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05.
other	36476775	hsa-mir-146a	Tuberculosis	The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05.
circulation_biomarker_diagnosis_ns	36476595	hsa-mir-16	Schizophrenia	A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people.
transcription factor target	36476351	hsa-mir-125b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Overall, our findings demonstrated novel functions and mechanisms underlying DDP resistance in NSCLC through the TRIM28/miR-125b-5p/CREB1 axis.
circulation_biomarker_diagnosis_up	36476264	hsa-mir-375	Pancreatic Carcinoma	Subcellular location analysis indicated that AK4P1 was mainly located in cytoplasm, in which AK4P1 might competitively bind to tumour suppressive miR-375 in pancreatic adenocarcinoma.
other	36476239	hsa-mir-19a	Carcinoma, Hepatocellular	Furthermore, a well-established circ_002136 ceRNA regulatory network was constructed, namely circ_002136 blocked miR-19a-3p expression, elevated RAB1A expression activity and stimulated HCC development. Finally, high levels of circ_002136 or RAB1A, as well as low levels of miR-19a-3p, negatively affected HCC patient survival.
circulation_biomarker_diagnosis_ns	36475430	hsa-mir-222	Pre-Eclampsia	3p expression in total plasma and plasma Exos, which both have high diagnostic efficiency for PE.
genetics_overexpression_promote	36475330	hsa-mir-122	Obesity	The miRNA hsa-miR5p (p < 0.05) was overexpressed in the obese group.
other	36475295	hsa-mir-381	Breast Neoplasms	A prediction model consisting of combination of miR-381 and Ki-67 and TN indicators could predict disease progression more effectively.
other	36474808	hsa-mir-140	Osteoarthritis	Here we present functional studies of canonical microRNA3p and two of its most prevalent isomiRs, a 5' isomiR and a 3' isomiR, in an inflammation-induced model of osteoarthritis (OA).
genetics_GWAS	36474749	hsa-mir-21	Neonatal Sepsis	AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis.
genetics_GWAS	36474749	hsa-mir-181b	Neonatal Sepsis	AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis.
lncRNA target	36474748	hsa-mir-221	Carcinoma, Hepatocellular	CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively.
lncRNA target	36474748	hsa-mir-122	Carcinoma, Hepatocellular	CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively.
circulation_biomarker_diagnosis_up	36474713	hsa-mir-103a	Venous Thrombosis	RESULTS: The upregulated expression levels of lncRNA XIST and HMGB1 and downregulated level of miR-103a-3p were found in the plasma of DVT patients and IL-1beta-treated HUVECs. CONCLUSION: lncRNA XIST sponged miR-103a-3p improving HMGB1 expression to exacerbate DVT by activating the ROS/NF-kappaB signaling pathway.
target gene	36474621	hsa-mir-204	Psoriasis	Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis.
transcription factor target	36474573	hsa-mir-27a	Diabetic Nephropathies	CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR.
other	36474573	hsa-mir-33a	Kidney Diseases	Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO.
transcription factor target	36474573	hsa-mir-27a	Kidney Diseases	CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR.
other	36474573	hsa-mir-33a	Diabetic Nephropathies	Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO.
circulation_biomarker_diagnosis_up	36474147	hsa-mir-552	Carcinoma, Hepatocellular	METTL14 promoted circFUT8 m6A modification and facilitated its nuclear export to the cytoplasm, where M1 macrophages regulated the circFUT8/miR3p/CHMP4B pathway, thereby suppressing HCC progression.
genetics_overexpression_promote	36474029	hsa-mir-4731	Cardiomegaly	The rescue experiments showed that miR-4731 overexpression attenuated the protective effects of circ_0018553 overexpression on the cardiac hypertrophy induced by Ang II; SIRT2 silencing also attenuated the protective effects of miR-4731 inhibition on the Ang II-induced cardiac hypertrophy.
genetics_knock down_promote	36473889	hsa-mir-27a	Femur Head Necrosis	The expressions of Runx2 in BMSCs and steroid-induced ONFH rats was significantly up-regulated, while IL-6, TNF-alpha, PPAR-gamma and ApoA5 were down-regulated with miR-27a overexpression.
circRNA target	36473706	hsa-mir-340	Cholangiocarcinoma	CONCLUSION: Hsa_circ_0,019,054 deficiency could attenuate the proliferation and glycolysis of ICC cells via miR
genetics_knock down_promote	36473369	hsa-mir-96	Lung Neoplasms	5p expression, it could promote or inhibit the proliferation, invasion and metastasis of H1299 cells after LDB2 knockdown or overexpression and regulate the expression of cyclinD1, MMP9, Bcl-2, and Bax via ERK1/2 signaling pathway.
genetics_overexpression_promote	36473368	hsa-mir-653	Laryngeal Papilloma	5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells.
other	36473367	hsa-mir-520e	Osteosarcoma	Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma.
other	36473367	hsa-mir-520b	Osteosarcoma	Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma.
lncRNA target	36471281	hsa-mir-29a	Prostatic Neoplasms	In summary, we demonstrated that LINC00852 played a key role in promoting the prostate cancer, and LINC00852/miR-29a-3p/JARID2 axis could be used as a target for prostate cancer treatment.
lncRNA target	36471277	hsa-mir-214	Esophageal Neoplasms	CONCLUSIONS: These results further support the tumor-suppressive role of miR
other	36470669	hsa-mir-22	Carcinoma, Hepatocellular	The mRNA expression of FGD5-AS1, LINC00858, SNHG16, and UBE4B was higher in the HCC cell lines (7721 and HepG2) than in the normal hepatocyte line (LO2), and the expression of hsa-miR3p mRNA showed a decreasing trend.
lncRNA target	36470227	hsa-mir-506	Neuralgia	3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis.
lncRNA target	36470227	hsa-mir-506	Brachial Plexus Avulsion 	3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis.
other	36469564	hsa-mir-200	Biliary Tract Neoplasms	Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer.
transcription factor target	36469307	hsa-mir-210	Obesity	Thus, miR3p inhibition in ATMs could serve as a novel therapeutic strategy for managing obesity-induced type 2 diabetes.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-21	Lupus Erythematosus, Systemic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-21	Anemia, Hemolytic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-210	Lupus Erythematosus, Systemic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-210	Anemia, Hemolytic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
exosome	36468636	hsa-mir-181a	Osteosarcoma	The results showed that exosomal miR-181a-5p derived from osteosarcoma cells induced polarization of M2 macrophages via targeting RORA.
other	36468451	hsa-mir-223	Colorectal Neoplasms	Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively.
other	36468451	hsa-mir-106a	Colorectal Neoplasms	Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively.
lncRNA target	36468227	hsa-mir-214	Myocardial Reperfusion Injury	MicroRNA3p protects against myocardial ischemia-reperfusion injury by targeting demethylase lysine demethylase 3A.
other	36468026	hsa-let-7	Pulmonary Disease, Chronic Obstructive	AIFM1-FKBP1A pathway also indicates new hypotheses of COPD pathology.
circRNA target	36467610	hsa-mir-124	Anxiety Disorders	3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity.
circRNA target	36467610	hsa-mir-124	Irritable Bowel Syndrome	3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity.
target gene	36467343	hsa-mir-95	Uterine Cervical Neoplasms	MiR-95-3p acts as a prognostic marker and promotes cervical cancer progression by targeting VCAM1.
therapeutic target	36467335	hsa-mir-345	Breast Neoplasms	Silencing the expression of lncRNA SNHG15 may be a novel therapeutic approach in human breast cancer through regulating miR-345-5p.
transcription factor target	36467048	hsa-mir-125b	Carcinoma, Non-Small-Cell Lung	Mechanistically, Curcumol downregulated the expression of SP1 (specificity protein 1) while upregulated miR-125b-5p, followed by decreasing VEGFA expression in NSCLC cells. Collectively, our study revealed that Curcumol inhibited cell growth and angiogenesis of NSCLC in vitro and in vivo, possibly through SP1/miR-125b-5p/VEGFA regulatory mechanism.
lncRNA target	36467040	hsa-mir-185	Heart Failure	3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR
circulation_biomarker_prognosis_ns	36466111	hsa-mir-210	Carcinoma, Pancreatic Ductal	Further detection of PDAC plasma exosomal miR-210 suggests that exosomal miR-210 expression was high and significantly associated with vascular invasion and TNM stage and was an independent risk factor for PDAC overall survival.
circulation_biomarker_diagnosis_ns	36465705	hsa-mir-210	Diabetes Mellitus, Type 2	This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then investigating the underlying mechanism of circulating miR-210 in T2DM.
transcription factor target	36464444	hsa-mir-155	Cardiovascular Diseases	In this work, a novel label-free and signal-off electrochemical biosensor based on efficient target-trigger T-structure recycling with dual strand displacement amplification (T-DSDA) was constructed for sensitive detection of miRNA-155 that related to cardiovascular diseases.
other	36464432	hsa-mir-455	Triple Negative Breast Neoplasms	The ECL sensing system was used to detect miRNA3p in the triple-negative breast cancer tumor tissues.
circulation_biomarker_diagnosis_up	36463825	hsa-mir-1246	Carcinoma, Non-Small-Cell Lung	Further investigation indicated that miR1246 was the most enriched microRNA in NSCLC-derived exosomes and mediated the partial effects of exosomes on microglia. Notably, miR1246 was also upregulated in the plasmatic exosomes of NSCLC patients.
lncRNA target	36463760	hsa-mir-206	Breast Neoplasms	Taken together, our results proved that the lncRNA COX10-DT could function via the COX10-DT/miR-206/BDNF axis, thereby promoting the development of breast cancer.
lncRNA target	36463687	hsa-mir-146a	Tendinopathy	Targeting the AC108925/miR-146a-3p axis might be a latent way to treat tendinopathy.
genetics_knock down_promote	36463188	hsa-mir-181a	Breast Neoplasms	Gain- and loss-of-function experiments were performed to explore the role of miR-181a in BC progression with the involvement of the AKT signaling pathway.
other	36463118	hsa-mir-122	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-29	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-155	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-196	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36462649	hsa-mir-140	brachydactyly type D	Results found that the expression of miR-140 in the articular cartilage of the KBD group was lower than that of the control group. Moreover, the occurrence of KBD might be related to the decreased expression of miR-140 in articular cartilage.
genetics_knock down_suppress	36462557	hsa-mir-125a	Carcinoma, Renal Cell	CONCLUSION: Circ_0000069 knockdown inhibited the carcinogenesis of RCC by regulating miR-125a-5p/SLC1A5 axis.
lncRNA target	36462499	hsa-mir-24	Melanoma	3p/MAPK1 axis in CMM, and revealed an alternative target for the diagnosis and treatment of CMM.
other	36462338	hsa-mir-197	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
other	36462338	hsa-mir-483	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
other	36462338	hsa-mir-885	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
lncRNA target	36462326	hsa-mir-205	Prostatic Neoplasms	5p inhibitors, siErBB3 could oppose SC-triggered pro-apoptotic effects on PCa cells.
circulation_biomarker_diagnosis_ns	36462101	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	miR-375, SHOX2 methylation, smoking history, neuron-specific enolase (NSE), and CYFRA21-1 levels were risk factors for NSCLC; the risk of NSCLC increased 25.763 times for each unit increase in plasma miR-375 level (OR = 25.763, CI: 1.726-384.529), and the risk of NSCLC increased 4.096 times for each unit increase in SHOX2 methylation (OR = 4.096, CI: 1.195-14.036).
circulation_biomarker_diagnosis_ns	36461796	hsa-mir-203	psoriasis 1	It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients.
circulation_biomarker_diagnosis_ns	36461796	hsa-mir-146a	psoriasis 1	It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients.
exosome	36461670	hsa-mir-217	Urinary Bladder Neoplasms	We conclude that bladder cancer tissue-derived exosomes inhibit ferroptosis of T24 bladder cancer cells by transporting miR-217.
genetics_GWAS	36461613	hsa-mir-587	Adenocarcinoma of Lung	Herein, the expression of lncRNA A2M-AS1, microRNA (miRNA) miR-587, and bone morphogenetic protein 3 (BMP3) in LUAD cell lines and tissues were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting.
other	36461592	hsa-mir-124	Alzheimer Disease	3p.
other	36461592	hsa-mir-124	Hyperuricemia	3p.
lncRNA target	36460840	hsa-mir-155	Ischemic Stroke	CONCLUSION: OIP5-AS1 suppressed oxidative stress and inflammatory response to alleviate cell injury caused by OGD/R induction in HMC3 and SH-SY5Y cells through regulating miR5p/IRF2BP2 axis, which might offer novel targeted molecules for ischemic stroke therapy.
transcription factor target	36460813	hsa-mir-205	Carcinoma, Hepatocellular	The study clearly reflects that hsa-mir5p is the signature miRNA for positively regulating angiogenesis in HCC through VEGFA.
genetics_overexpression_promote	36460812	hsa-mir-146b	Multiple Myeloma	The inhibitory effects of NDNF upregulation on MM cell growth, colony formation, and migration were partially abolished by miR-146b-3p overexpression.
lncRNA target	36460802	hsa-mir-23a	Glioma	Collectively, these data suggest that GAS5 functions as a suppressor in GSCs by targeting the miR-23a/E-cadherin axis, which may be a promising therapeutic target against glioma.
genetics_knock down_promote	36460200	hsa-mir-4306	Intervertebral Disc Degeneration	As expected, MIR4306 overexpression inhibited ECM degradation in degenerated NPCs by downregulating EPAS1.
circRNA target	36459832	hsa-mir-876	Esophageal Neoplasms	CONCLUSION: Circ_0001686 contributed to the progression and radioresistance of esophagus cancer cells via regulating SPIN1 expression by targeting miR
genetics_overexpression_promote	36459592	hsa-mir-143	Dementia, Vascular	Overexpression of miR
other	36459290	hsa-mir-21	Breast Neoplasms	RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively.
circulation_biomarker_diagnosis_ns	36459290	hsa-mir-145	Breast Neoplasms	CONCLUSION: Based on our results, we conclude that the detection of serum miRNA-145, -382 and -21 as a panel along with glutamic acid, and circulating HER2 concentrations could be useful as a non-invasive diagnostic profiling for early prediction of breast cancer in Egyptian patients.
other	36459290	hsa-mir-382	Breast Neoplasms	RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively.
transcription factor target	36459288	hsa-mir-588	high grade glioma	CONCLUSIONS: MiR-588 regulated the behaviors of hypoxic glioma cells by targeting ROBO1.
lncRNA target	36459288	hsa-mir-588	Carcinoma, Hepatocellular	MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive.
lncRNA target	36459288	hsa-mir-588	Glioblastoma	MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive.
lncRNA target	36459268	hsa-mir-30	Colorectal Neoplasms	3p/CNBP axis in CRC, highlighting the potential of circPACRGL as a therapeutic target for colorectal cancer.
other	36459254	hsa-mir-155	Periodontitis	The result suggested that miRNA-155 does not affect the expression of MITF gene in the process of osteoclastogenesis in localized stage III/IV periodontitis within this study design and limitations.
lncRNA target	36458392	hsa-mir-449a	Peripheral Nerve Injuries	CONCLUSIONS: BMSCs can modulate NF-kappaB signaling pathway by targeting miR-449a, so as to reduce the inflammatory response to peripheral nerve injury and repair nerve injury.
genetics_GWAS	36457982	hsa-mir-155	Behcet Syndrome	MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p &lt; 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021).
genetics_GWAS	36457982	hsa-mir-146a	Behcet Syndrome	MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p &lt; 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021).
other	36457981	hsa-mir-125b	Cholesteatoma	Low expression of microRNA-125b enhances the expression of STAT3 and contributes to cholesteatoma growth.
lncRNA target	36457977	hsa-mir-20a	Osteoporosis	MATERIAL AND METHODS: The expression of MALAT1 and miR-320a was determined using RT-PCR in bone tissue derived from female SD (Sprague Dawley) rats with osteoporosis. CONCLUSIONS: Downregulated MALAT1 and upregulated miR-320a expression play an important role in the pathological process of osteoporosis, via inhibition of the osteogenic differentiation of BMSCs.
other	36457973	hsa-mir-23b	Osteoporosis	It has been reported previously that miR-23b-3p is involved in osteoporosis and in regulation of differentiation of osteoblasts.
other	36457880	hsa-let-7e	Inflammation	CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway.
other	36457880	hsa-mir-20a	Inflammation	CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway.
circulation_biomarker_diagnosis_ns	36457743	hsa-mir-222	Carcinoma, Hepatocellular	The serum and tissue expression of miRNAs (Let-7a, miR-26a, miR-124, miR-155, miR-221, miR-222, and miR-340) were differentially expressed in HCC patients (p &lt; 0.05).
other	36457244	hsa-mir-454	Pancreatic Carcinoma	RESULTS: We revealed CDK6 might be an oncogene in PC, and the HOXA11-AS /NR2F1-AS1- miR3p axis was identified as the possible upstream ncRNA-associated pathway of CDK6 in PC.
other	36457077	hsa-mir-24	Colorectal Neoplasms	In follow-up experiments, we demonstrate that miR3p promotes CRC cell survival in multiple cell contexts.
genetics_knock down_promote	36457055	hsa-mir-8114	Seizures	Moreover, both circ_0001293 knockdown and miR-8114 overexpression reversed the beneficial effects of HsTx2 on inflammation, epilepsy progression, and the MAPK and NF-kappaB signaling pathways in vivo. CONCLUSIONS: HsTx2 suppressed PTZ-induced epilepsy by ameliorating inflammation in astrocytes via the circ_0001293/miR-8114/TGF-beta2 axis.
transcription factor target	36457036	hsa-mir-378a	Colorectal Neoplasms	Phenotypically, by reducing polyamine synthesis, miR-378a induced apoptosis and inhibited proliferation and migration of CRC cells, while disrupting the association of miR-378a with FOXQ1 and ODC1 offset the effects of miR-378a, suggesting that FOXQ1 and ODC1 were required for miR-378a to inhibit CRC cell growth.
lncRNA target	36457028	hsa-mir-133a	Uterine Cervical Neoplasms	369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3.
lncRNA target	36457028	hsa-mir-379	Uterine Cervical Neoplasms	369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3.
exosome	36457020	hsa-mir-142	hereditary diffuse gastric cancer	For accurate diagnosis of gastric cancer patients, a combination of LDT-CHA and a panel of four sEV-miRNAs (sEV-miR-1246, sEV-miR-21, sEV-miR
other	36456979	hsa-mir-576	Esophageal Neoplasms	5p/AHR were critical molecular pathways related to the radiosensitivity of esophageal cancer.
transcription factor target	36456413	hsa-mir-663a	Fibrosis	CONCLUSION: Our study identified lnc-C18orf26-1 and miR-663a as promising therapeutic targets for hepatic fibrosis.
circulation_biomarker_prognosis_ns	36456138	hsa-mir-21	Ovarian Neoplasms	CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer.
circulation_biomarker_prognosis_ns	36456138	hsa-mir-1	Ovarian Neoplasms	CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer.
exosome	36455873	hsa-mir-584	Postoperative Cognitive Complications	CONCLUSIONS: Sevoflurane-induced POCD-associated exosomes delivered miR
other	36455651	hsa-mir-152	Obesity	3p were associated with insulin resistance.
other	36455651	hsa-mir-423	Obesity	3p were associated with insulin resistance.
other	36455323	hsa-mir-6238	Acute Lung Injury	Collectively, our findings suggest that miR-6238 is a novel regulator of pulmonary inflammation and a putative biomarker that distinguishes PM-induced ALI from endotoxin (LPS/PTG)-mediated ALI.
genetics_overexpression_suppress	36455140	hsa-mir-143	Wilms Tumor	Meanwhile, overexpression of k-Ras reversed the inhibitory effects on WT cells induced by miR
lncRNA target	36454533	hsa-mir-210	Cholangiocarcinoma	It was further confirmed in vivo that miR-210 shuttled by tumor cell-derived EVs could specifically inhibit RECK expression, which promotes growth, metastasis and chemoresistance of CCA cells.
genetics_knock down_promote	36454505	hsa-mir-433	Glioma	3p overexpression-mediated effects on glioma cell clonogenicity, migration, and apoptosis.
circulation_biomarker_diagnosis_down	36454178	hsa-mir-191	Alzheimer Disease	5p in plasma/serum has been identified as a novel and promising noninvasive diagnostic biomarker for AD.
other	36454035	hsa-let-7d	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
other	36454035	hsa-mir-29a	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
other	36454035	hsa-mir-181b	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
genetics_knock down_suppress	36453878	hsa-mir-361	Esophageal Neoplasms	3p inhibitor rescued the anti-tumour effect of BBOX1-AS1 knockdown on the progression of EC.
other	36452459	hsa-let-7b	Leukemia	CTDSP1 was significantly downregulated in T-ALL compared to normal controls, which might be originated from the hyperediting of hsa-let-7b-5p in T-ALL.
other	36452459	hsa-mir-21	Leukemia	5p decreased in chronic lymphocytic leukemia patients with radiation treatments.
other	36452459	hsa-mir-155	Leukemia	5p decreased in chronic lymphocytic leukemia patients with radiation treatments.
other	36452144	hsa-mir-214	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-mir-148a	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-let-7b	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-mir-26a	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36451863	hsa-mir-92a-2	Multiple Myeloma	3p expression.
lncRNA target	36451861	hsa-mir-126	Triple Negative Breast Neoplasms	Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors.
lncRNA target	36451861	hsa-mir-126	Pancreatic Carcinoma	Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors.
other	36451157	hsa-mir-17	Neuroectodermal Tumors, Primitive	The sperm sRNA sequencing revealed that the expression of the developmental miR92 cluster and the Sfmbt2 miRNA cluster was downregulated in the OEE group.
lncRNA target	36451051	hsa-mir-580	Stomach Neoplasms	SOX2-activated Linc-ROR serves as a cancer suppressor to restrain GCa progression in vitro via the miR
genetics_knock down_suppress	36450557	hsa-mir-214	Reperfusion Injury, Ischemia	SOX6 knockdown overturned the circTRRAP overexpression-induced effects in AC16 cardiomyocytes.In conclusion, the silence of circTRRAP was implicated in Sal B-mediated cardioprotective effects against I/R injury by regulating the miR3p/SOX6 axis.
circulation_biomarker_diagnosis_ns	36450556	hsa-mir-22	Graft Occlusion, Vascular	Peripheral blood samples were acquired from patients with in-stent restenosis (ISR) after percutaneous coronary intervention (PCI), with subsequent quantitative reverse transcription (qRT) -polymerase chain reaction (PCR) and Western blot analyses of miR
circulation_biomarker_diagnosis_ns	36450556	hsa-mir-22	Ciliary Motility Disorders	The peripheral blood of patients with ISR after PCI had low expression of miR
transcription factor target	36450556	hsa-mir-22	Cardiovascular Diseases	Conclusively, miR3p could repress VSMC proliferation, phenotypic transformation, and migration by targeting TOMM40, which might be a possible treatment candidate for restenosis after PCI in patients with cardiovascular disease.
circulation_biomarker_diagnosis_ns	36449688	hsa-mir-590	Reperfusion Injury, Renal Ischemia	RESULTS: miR3p was highly enriched in the plasma exosomes of young AKI patients after cardiac surgery.
other	36449366	hsa-mir-122	Hepatitis C	MicroRNA-122 (miR-122) is the most abundant miRNA in the liver and has been linked to the development of hepatocellular carcinoma and hepatitis C virus (HCV) infection.
lncRNA target	36449143	hsa-mir-488	Stomach Neoplasms	Overall, HULC re-expression elicited by miR-488 inhibition can enhance EZH2-H3K27me3 enrichment in the p53 promoter and repress the p53 expression, thus promoting the growth and metastasis of GC.
transcription factor target	36448837	hsa-mir-15a	Acute Lung Injury	The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response.
transcription factor target	36448837	hsa-mir-15a	Sepsis	The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response.
exosome	36448712	hsa-mir-518a	Ovarian Neoplasms	OC-derived exosomal circNFIX promoted angiogenesis by regulating the Janus-activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR-518a-3p/TRIM44 axis in HUVECs.
other	36448711	hsa-mir-223	Liver Neoplasms	Herein, we propose a simple and sensitive mass spectrometric method for the multiplex detection of nucleic acid and protein, in which liver cancer-related biomarkers miRNA 223 and alpha-fetoprotein (AFP) were selected as model analytes.
genetics_GWAS	36448327	hsa-mir-124	Ischemic Stroke	Finally, the suppressed of PARP1 was induced by gain-binding ability of miR5p through 3'UTR directly binding.Conclusions: In conclusion, our study demonstrates that the SNP rs8679 in PARP1 3'-UTR might act as a protective factor for the outcome of patients with ischemic stroke.
other	36447429	hsa-mir-223	Melanoma	miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells.
other	36447429	hsa-mir-181a	Melanoma	miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells.
target gene	36447254	hsa-mir-506	Stomach Neoplasms	Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism.
lncRNA target	36447214	hsa-mir-200b	Stomach Neoplasms	The StarBase database was used to predict that 3 pseudogenes and 7 lncRNAs might inhibit the hsa-miR-200b-3p-COL5A2 axis in gastric cancer. CONCLUSIONS: We elucidated the regulatory role of the pseudogenes/lncRNA-hsa-miR-200b-3p-COL5A2 network in gastric cancer progression and constructed a nomogram.
circulation_biomarker_diagnosis_ns	36446758	hsa-mir-148a	Bone Diseases	Finally, the miR-148a level was found to be positively correlated with beta-CTX in postmenopausal osteoporosis (PMOP) serum specimens. In osteoclast-related bone metabolic diseases such as PMOP, miR-148a may be an attractive therapeutic target in the future.
other	36446162	hsa-mir-4455	Cognitive Dysfunction	The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy.
other	36446162	hsa-let-7b	Cognitive Dysfunction	The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy.
lncRNA target	36446154	hsa-mir-1322	Myocardial Ischemia	CONCLUSION: Our results suggested that miR-1322 can protect against the myocardial ischemia via LRP8/PI3K/AKT pathway.
genetics_overexpression_suppress	36445955	hsa-mir-34a	Carcinoma, Hepatocellular	Overexpression of miR-34a-5p counteracts CSC properties and enhances radiosensitivity in HCC.
other	36445630	hsa-mir-6085	Cerebral Infarction	Celastrol ameliorated OGD/R-induced HBMEC apoptosis and oxidative stress by circDLGAP4/miR-6085/GDF11 pathway, supporting the use of Celastrol as a therapeutic agent for cerebral infarction.
genetics_knock down_promote	36445573	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Knockdown of MAPKAPK5-AS1 inhibited the aggressive tumor phenotypes through miR
lncRNA target	36445120	hsa-let-7b	Colonic Neoplasms	Let-7b-5p was found to inhibit proliferation, migration, and invasion of colon cancer cells targeting NKD1. This research revealed a novel mechanism by which the let-7b-5p-NKD1-APC-beta-catenin signaling pathway inhibited colon cancer cell progression.
genetics_overexpression_promote	36445107	hsa-mir-548ag	Obesity	Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals.
genetics_overexpression_promote	36445107	hsa-mir-548ag	Endometrial Neoplasms	Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals.
tissue_expression_ns	36444993	hsa-mir-181a-2	Myelodysplastic Syndromes	Although abnormal microRNA expression has been implicated in MDS, the exact role of miR-181a3p has not been entirely elucidated. Here, we investigated miR-181a3p levels in bone marrow (BM), and described its utility as a potential indicator for MDS diagnosis and prognosis. METHODS: We evaluated miR-181a3p expression in BM samples of 54 newly diagnosed MDS cases, 16 sAML patients and 32 healthy donors and then assessed its association with clinical characteristics and its potential value for MDS diagnosis and prognosis. RESULTS: Compared with healthy controls, miR-181a3p levels were decreased in the total cohort of MDS patients. Additionally, in MDS patients with secondary AML (sAML), miR-181a3p was over-expressed relative to levels in those without this form. Further, multivariate analysis indicated that miR-181a3p was an independent prognostic index for MDS with respect to OS. CONCLUSION: Decreased miR-181a3p expression in MDS patients may be considered as one of the underlying markers reflecting MDS progression and prognosis.
genetics_knock down_promote	36444938	hsa-mir-6838	Uterine Cervical Neoplasms	Functional investigations revealed that CERS6-AS1 knockdown inhibited proliferation and invasion, and promoted apoptosis in CC cells, which was reversed by miR
genetics_overexpression_promote	36444911	hsa-mir-708	Retinoblastoma	Furthermore, retinoblastoma cells overexpressing miR-708 exhibited a markedly lower migratory rate and invasiveness compared to negative control cells.
circRNA target	36444635	hsa-mir-518a	Periodontal Diseases	CONCLUSION: Circ_0138960 promoted LPS-induced dysfunction in PDLCs by targeting miR-518a-5p/HDAC6 axis, which provided novel potential therapeutic targets for periodontitis.
genetics_GWAS	36444590	hsa-mir-423	Breast Neoplasms	The goal of this study was to determine if there was a link between the miR-423 rs6505162 gene variation and breast cancer susceptibility among Egyptian patients. CONCLUSION: Our data suggest that miR-423 rs6505162 polymorphism could be a potential risk factor in the pathogenesis of breast cancer among Egyptian population.
circRNA target	36444162	hsa-mir-1236	Osteosarcoma	CONCLUSION: Circ_0000253 promotes OS cell proliferation and suppresses cell apoptosis via regulating the miR
circRNA target	36443854	hsa-mir-667	Non-alcoholic Fatty Liver Disease	5p/SIRT1 axis reversed its effects, suggesting that targeting circLDLR/miR
other	36443711	hsa-mir-142	Breast Neoplasms	5p /RAC1/PAK1 axis.
genetics_overexpression_promote	36442661	hsa-mir-20b	Carcinoma, Hepatocellular	Mechanically, circITCH elevated PTEN expression to inactivate the PI3K/Akt signals through negatively regulating miR-20b-5p in HCC, and upregulating miR-20b-5p or inhibiting PTEN abolished the enhancing effect of circITCH overexpression on sorafenib-induced cytotoxicity in sorafenib-resistant HCC cells. CONCLUSION: Taken together, this study proves that circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells via regulating the miR-20b-5p/PTEN/PI3K/Akt signaling cascade, which highlights the potential value of circITCH as a target for enhancing the sorafenib-sensitivity in HCC.
transcription factor target	36442170	hsa-mir-1	Breast Neoplasms	ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells.
transcription factor target	36442170	hsa-mir-2	Breast Neoplasms	ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells.
genetics_knock down_promote	36441929	hsa-mir-140	Intracranial Aneurysm	Knockdown of miR-140 alleviates the development of intracranial aneurysms.
genetics_overexpression_suppress	36441170	hsa-mir-139	Urinary Bladder Neoplasms	Subsequent experimental results presented that overexpressing KIF18B could reverse inhibitory effect of overexpressing miRNA
genetics_overexpression_promote	36441004	hsa-mir-93	Urinary Bladder Neoplasms	Overexpression of PAFAH1B1 could efficiently reverse the effects of miR
other	36440973	hsa-mir-223	Complex Regional Pain Syndromes	In particular, microRNAs, such as miR-223, decreased in CRPS, have been described only in cross-sectional studies. CONCLUSION: We identified progressively reduced miR-223 as a putative biomarker of chronic CRPS pain.
transcription factor target	36440907	hsa-mir-124	Inflammatory Bowel Diseases	Collectively, Rauwolfia-derived PPs limited miR3p and targeted RBP4 and reduced the binding potency of RBP4 to NLRP3 to inhibit NLRP3-mediated pyroptosis, resulting in the alleviation of colonic epithelial cell pyroptosis and mucosal damages in UC.
genetics_overexpression_promote	36440854	hsa-mir-1	renal fibrosis	NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo.
other	36440749	hsa-mir-146a	Osteoarthritis	Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model.
other	36440749	hsa-mir-140	Osteoarthritis	Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model.
circulation_biomarker_diagnosis_ns	36440364	hsa-mir-146a	Arthritis, Rheumatoid	FLS were cocultured with WJR-containing serum to observe the effects of miRNA-146a-mediated autophagy via the PI3K/AKT/mTOR pathway on CIA-affected rats.
other	36440217	hsa-mir-21	Osteoporosis, Postmenopausal	Our findings suggest that whole-body vibration is a sufficient mechanical stimulus for altering c-miR5p expression, whereas a high intensity resistance exercise protocol did not elicit any c-miRNA responses in postmenopausal women.
other	36440215	hsa-mir-218	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-mir-517b	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-let-7a	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-mir-517a	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
lncRNA target	36440209	hsa-mir-107	Diabetes Mellitus, Type 1	CONCLUSION: Our results suggest that lncRNA such as lncRNA PVT1, LINC00960 and hsa-miR-107 might be involved in inflammation response in T1DM, and the former lncRNA chose in the present study may serve as novel biomarkers and potential targets for the diagnosis and treatment of T1DM.
target gene	36439901	hsa-mir-136	Uterine Cervical Neoplasms	Circular RNA circ_0004488 Increases Cervical Cancer Paclitaxel Resistance via the miR-136/MEX3C Signaling Pathway.
other	36439523	hsa-mir-550a	Adenocarcinoma of Lung	A nomogram consisting of BMI, history of chronic pain, miR 550a-3p, and VAS2d predicted the risk of CPSP after VATS in patients with lung adenocarcinoma.
other	36438900	hsa-mir-125b	Periodontitis	VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging.
other	36438900	hsa-mir-21	Periodontitis	VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging.
circulation_biomarker_diagnosis_up	36438898	hsa-mir-125b	Vitiligo	RESULTS: Compared with the healthy control group, the expression of miR-125b-5p in the tissues and serum of vitiligo patients was upregulated, and the expression of MITF was downregulated; compared with PIG1 cells, the expression of miR-125b-5p and MITF in the PIG3V group was consistent with the above.
transcription factor target	36438895	hsa-mir-877	Breast Neoplasms	5p inhibits epithelial mesenchymal transformation, cell proliferation, and invasion of BC cells via downregulating FGB.
circulation_biomarker_diagnosis_ns	36437340	hsa-mir-652	Pre-Eclampsia	3p, the level of SUMO 1-4 and UBC9 in the placenta, reduced concentration of PlGF, and increased sFlt-1/PlGF ratio in the blood of pregnant women with early-onset preeclampsia, which attests to the presence of a regulatory mechanism along the axis of miR
other	36437242	hsa-mir-17	skin melanoma	Seven immune-related CM prognostic molecules, including three mRNAs (SUCO, BTN3A1 and TBC1D2), three lncRNAs (HLA-DQB1-AS1, C9orf139 and C22orf34) and one miRNA (hsa-miR5p), were screened by differential expression analysis, ceRNA network analysis, LASSO Cox regression analysis and univariate Cox regression analysis.
genetics_knock down_promote	36436795	hsa-mir-1227	Osteoarthritis	3p inhibitor reversed the effect of circ_0114876 knockdown on the OA chondrocytes, and ADAM10 overexpression reversed the effect of miR
circulation_biomarker_diagnosis_down	36436490	hsa-mir-205	Kidney Diseases	Hence, our study sought to study the possible modulatory effect of rosuvastatin on miR-205 and its downstream target, Egl-9 family hypoxia-inducible factor 2 (EGLN2) to combat oxidative and endoplasmic reticulum (ER) stresses as pivotal contributors to colistin-associated renal injury.
transcription factor target	36436380	hsa-mir-129	Vitamin B Deficiency	These data indicates that miR3p affected ferroptosis under Se deficiency conditions through the SLC7A11 pathway.
genetics_overexpression_suppress	36436380	hsa-mir-129	Siderosis	3p/SLC7A11 axis could involve in the process of ferroptosis, our further research showed that overexpression of miR
other	36436380	hsa-mir-129	Deficiency Diseases	The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased.
other	36436380	hsa-mir-129	Liver Diseases	The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased.
lncRNA target	36436369	hsa-mir-223	Non-alcoholic Fatty Liver Disease	These results indicated that PAMK could relieve inflammatory liver tissue damage after LPS treatment and downregulate the level of inflammation factors via miR-223/NLRP3 axis, thus playing a liver protective role in liver inflammation injury in goslings.
transcription factor target	36436343	hsa-mir-338	Colorectal Neoplasms	3p, which may be a therapeutic target for CRC.
circRNA target	36436315	hsa-mir-506	Triple Negative Breast Neoplasms	3p was found to suppress proliferation and facilitate apoptosis of TNBC cells.
transcription factor target	36436291	hsa-mir-28	Otitis Media	Furthermore, in vivo experiments confirmed that CF-lenti-miR-28 inhibitor-Evs injection down-regulated the number of TRAP (+) MNCs and inhibited tooth movement of OTM rats.
genetics_knock down_promote	36436251	hsa-mir-204	Aortic Aneurysm, Abdominal	5p levels and reduced the expression of Mekk3, whereas lincRNA-p21 overexpression had the opposite effect.
other	36435921	hsa-mir-34a	Esophageal Squamous Cell Carcinoma	CONCLUSION: Our results not only provide evidence that HPV16 E6 promotes cell proliferation, migration, and invasion in ESCC, but also suggests a correlation between HPV infection and E6AP, p53 and miR-34a expression.
genetics_knock down_suppress	36435914	hsa-mir-140	Osteoarthritis	CONCLUSION: Circ_0136474 knockdown alleviated IL-1beta-triggered CHON-001 cell damage through modulation of miR3p/MECP2 axis, indicating a new target for treatment of OA.
other	36435866	hsa-mir-205	Carcinoma, Hepatocellular	CONCLUSION: Our data indicate that a LINC00152/miR5p/CXCL11 axis in HCC CAFs can affect the proliferative and migrative abilities of HCC cells in vitro and HCC tumor growth in vivo.
circulation_biomarker_diagnosis_up	36435781	hsa-mir-150	Lupus Erythematosus, Systemic	5p in peripheral blood mononuclear cells of SLE.
lncRNA target	36435763	hsa-mir-145	Femur Head Necrosis	In conclusion, miR-145 regulates the proliferation and differentiation of glucocorticoid-induced BMSC cells through GABARAPL1 and pharmacologically inhibit targeting miR-145 may provide new aspect for the treatment of SANFH.
lncRNA target	36435226	hsa-mir-370	Liver Cirrhosis	3p/Irak2 axis might be a novel identifier and therapeutic target for HF.
lncRNA target	36434857	hsa-mir-342	Brain Ischemia	5p on cerebral ischemia injury as well as novel targets for stroke.
circulation_biomarker_diagnosis_ns	36434610	hsa-mir-148a	Prostatic Neoplasms	Here, we investigated the correlation between the serum miR-148a-3p and miR5p expression levels and cancer recurrence in PCa patients, aiming to identify new biomarkers for diagnosis and predicting postoperative recurrence of prostate cancer.
circulation_biomarker_diagnosis_ns	36434610	hsa-mir-485	Prostatic Neoplasms	CONCLUSION: Pre-surgery serum miR-148a-3p level positively correlates while miR
lncRNA target	36434587	hsa-mir-101	Urinary Bladder Neoplasms	The promoting effects of NEAT1 on bladder cancer cells were reversed by miR-101 upregulation, and inhibition of miR-101 enhanced the effects of NEAT1.
other	36434577	hsa-mir-671	Lung Neoplasms	CONCLUSIONS: Elevated circ_0017109 expression promotes tumor progression of NSCLC by modulating miR5p/FZD4/beta-catenin axis.
circulation_biomarker_diagnosis_up	36434569	hsa-mir-15a	Primary Ovarian Insufficiency	RESULTS: miR-15a-5p was increased whilst Stat3 was decreased in the serum of POI patients and SS-induced KGN cells.
exosome	36434177	hsa-mir-375	Prostatic Neoplasms	In conclusion, our study suggests that cancer-derived exosomal miR-375 targets DIP2C, activates the Wnt signaling pathway, and promotes osteoblastic metastasis and PCa progression.
other	36433987	hsa-mir-124	Atherosclerosis	Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis.
other	36433987	hsa-mir-16	Atherosclerosis	Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis.
transcription factor target	36433652	hsa-mir-10b	Colorectal Neoplasms	The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues.
transcription factor target	36433652	hsa-mir-182	Colorectal Neoplasms	The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues.
circulation_biomarker_diagnosis_ns	36432575	hsa-mir-221	Diabetes Mellitus	We aimed to measure the adipose and plasma miR-221 and -222 levels, and to evaluate their association with adiposity, glucose intolerance, and new onset diabetes mellitus (NODM) after the commencement of PD. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
other	36432575	hsa-mir-221	Insulin Resistance	CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
circulation_biomarker_diagnosis_ns	36432575	hsa-mir-221	Obesity	Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin BACKGROUND: The correlation between microRNA, obesity, and glycemic intolerance in patients on peritoneal dialysis (PD) is unknown. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
circulation_biomarker_diagnosis_up	36432399	hsa-mir-103a	Diabetes, Gestational	The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR
circulation_biomarker_diagnosis_up	36432399	hsa-mir-222	Diabetes, Gestational	The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR
genetics_GWAS	36431040	hsa-mir-27a	Cardiovascular Diseases	Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls.
genetics_GWAS	36431040	hsa-mir-27a	Coronary Artery Disease	Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls.
lncRNA target	36430972	hsa-mir-29a	Tuberous Sclerosis	Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p).
lncRNA target	36430972	hsa-mir-33a	Tuberous Sclerosis	Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p).
lncRNA target	36430715	hsa-mir-169	Dehydration	The improved drought tolerance might be involved in the decreased expression levels of miRNA such as mtr_miR169l-5p, mtr_miR398b, and mtr_miR398c and its target genes in seedlings with active nodules. During severe drought stress, the lncRNA alternative splicings TCONS_00049507 and TCONS_00049510 competitively interacted with mtr_miR169l-5p, which upregulated the expression of NUCLEAR FACTOR-Y (NF-Y) transcription factor subfamily NF-YA genes MtNF-YA2 and MtNF-YA3 to regulate their downstream drought-response genes.
genetics_overexpression_promote	36430501	hsa-mir-408	Neutropenia, Severe Congenital, Autosomal Recessive 4	Overexpressing miR408 could negatively regulate soybean resistance to SCN by suppressing reactive oxygen species accumulation. Conversely, silencing miR408 positively regulates soybean resistance to SCN.
transcription factor target	36430468	hsa-mir-223	Rhabdomyosarcoma	Interestingly, IGF1R resulted in the direct target of miR-223 in AYA-RMS cells, as demonstrated by IGF1R silencing.
other	36430249	hsa-mir-369	Inflammatory Bowel Diseases	Our data suggest that miR3p may be a future alternative therapeutic approach to several compounds currently used for the treatment of inflammatory disorders including IBD.
lncRNA target	36430219	hsa-mir-592	Neuroblastoma	In conclusion, this study develops a lipid-metabolism-related gene-based prognostic model for NB and demonstrates that GDPD5 inhibits SH-SY5Y proliferation and migration and may be targeted by hsa-miR-592 and inhibit SH-SY5Y fat synthesis.
genetics_overexpression_promote	36430152	hsa-mir-515	Glioblastoma	TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies.
genetics_overexpression_promote	36430152	hsa-mir-126	Glioblastoma	TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies.
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-6851	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-8068	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-506	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-144	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
other	36428476	hsa-mir-26a	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-186	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-210	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-205	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-199a	Osteoarthritis, Knee	5p were detectable only in a few samples.
transcription factor target	36427803	hsa-mir-615	Carcinoma, Non-Small-Cell Lung	In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR
transcription factor target	36427803	hsa-mir-744	Carcinoma, Non-Small-Cell Lung	In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR
epigenetics	36427628	hsa-mir-299	Insulin Resistance	5p-targeted resistin inhibition through demethylation, which underlies the mechanism of reducing IR.
epigenetics	36427628	hsa-mir-299	Myotonic Dystrophy	5p) expression was deficient in T2MD, which could be restored by aerobic exercise through modulating the DNA methylation modification enzymes.
other	36427609	hsa-mir-130b	Bone Diseases	The predicted circ_CUX1/miR-130b-5p/p300 axis might pave the way for better diagnostic and therapeutic approaches for bone-related diseases.
lncRNA target	36427469	hsa-mir-150	Endometriosis	CONCLUSION: MiR5p silencing inhibited hypoxia-induced autophagy and EMT of endometriotic cells by regulating the PDCD4/NF-kappaB signaling pathway.
other	36427432	hsa-mir-141	Pre-Eclampsia	Therefore, our data demonstrated that miR3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia.
other	36427432	hsa-mir-141	Pneumonia, Mycoplasma	3p), a multifunctional miRNA, is involved in a variety of physiological and pathological processes, including PE and autophagy.
other	36427432	hsa-mir-141	Hypoxia	3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia.
target gene	36426731	hsa-mir-337	Carcinoma, Non-Small-Cell Lung	Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3.
genetics_knock down_promote	36426627	hsa-mir-485	Breast Neoplasms	3p expression weakened the inhibiting effect of circ_0000129 knockdown on BC cell malignant behaviors.
genetics_overexpression_promote	36426595	hsa-mir-146a	Depressive Disorder, Major	CONCLUSIONS: The findings of this study reveal a relationship between miR-146a-5p overexpression and cortical atrophy and thus may help specify the in vivo mediating effect of miR-146a-5p dysregulation on brain structural abnormalities in patients with MDD.
circulation_biomarker_diagnosis_ns	36426578	hsa-mir-182	Triple Negative Breast Neoplasms	Finally, LNPs-miR3p were able to cross the blood-brain barrier and reduce intracranial tumors representing a possible therapeutic option for metastatic brain lesions.
lncRNA target	36426391	hsa-mir-150	Diabetes Mellitus, Type 2	5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19.
lncRNA target	36426391	hsa-mir-150	COVID-19	5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19.
other	36425259	hsa-mir-146a	Periodontal Diseases	Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation.
target gene	36424798	hsa-mir-374a	Stomach Neoplasms	Gastric cancer derived mesenchymal stem cells promote the migration of gastric cancer cells through miR-374a-5p.
circulation_biomarker_diagnosis_up	36424716	hsa-mir-184	Mucocutaneous Lymph Node Syndrome	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-19a	Mucocutaneous Lymph Node Syndrome	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-19a	limb ischemia	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-184	limb ischemia	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
genetics_knock down_promote	36424704	hsa-mir-202	Carcinoma, Endometrioid	5p depletion or CTNND1 overexpression, respectively.
exosome	36424471	hsa-mir-1228	Carcinoma, Hepatocellular	All in all, CAF-EV-carried miR
lncRNA target	36424455	hsa-mir-122	Acute Liver Injury	This study identifies a novel lncRNA with protective effects in acute liver injury and demonstrates that the binding of Mir122hg-C/EBPalpha promotes hepatocyte proliferation via upregulation of CXC chemokine and activation of AKT signaling.
exosome	36423858	hsa-mir-100	Endometriosis	Collectively, hUC-MSC-EV-loaded miR-100 downregulated HS3ST2 to facilitate the development of endometriosis, which highlights a promising therapeutic target for treating endometriosis.
genetics_overexpression_suppress	36423467	hsa-mir-203a	Elliptocytosis 2	These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways.
genetics_overexpression_suppress	36423467	hsa-mir-34b	Elliptocytosis 2	These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways.
transcription factor target	36423467	hsa-mir-203a	Abnormalities, Drug-Induced	When DEGs of miR-203a inhibitor-injected embryos were compared with BaP-exposed DEGs, alterations in nervous system development and function, and abnormal morphology of the neurosensory retina, eye and nervous tissue were predicted, consistent with both AhR and non-AhR pathways.
circulation_biomarker_diagnosis_ns	36423393	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Significantly, accurate evaluation of miRNA-21 expression levels in cancer cell lines and non-small-cell lung carcinomas (NSCLC) serum samples are successfully achieved using the developed method.
lncRNA target	36423383	hsa-mir-146b	Thyroid Neoplasms	These findings support that targeting the LINC01311/miR-146b-5p/IMPA2 axis may be a promising approach against TC progression.
exosome	36423379	hsa-mir-24	Non-alcoholic Fatty Liver Disease	Collectively, our study demonstrated that MSCs-derived exosomal miR3p had hepaprotective effects through targeting Keap-1 signaling, providing a potential therapeutic value for NAFLD treatment.
lncRNA target	36422738	hsa-mir-1179	Stomach Neoplasms	Additionally, microRNA-1179 was found to play a key role in inhibiting the expression of ALDOA in the metabolic pathways of GC cells, which might disrupt the expression of various immune molecules and be detrimental to the prognosis of GC.
circulation_biomarker_diagnosis_up	36422510	hsa-mir-373	Alzheimer Disease	METHODS: The expression levels of miR-204 and miR-373 were investigated in neuron-derived serum exosomes obtained from 15 patients with mild AD, 18 with moderate AD, and 21 cognitively healthy individuals.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-33a	Liver Diseases	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-33a	Fatty Liver	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-200c	Liver Diseases	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-200c	Fatty Liver	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
other	36421832	hsa-mir-1246	Pleural Effusion, Malignant	miRNA-1246 demonstrated 4-fold increased expression (OR: 3.87, 95% CI: 0.43, 35) in the MPE vs.
other	36421832	hsa-mir-150	Pleural Effusion, Malignant	HF-PE group and miR5p and miR-1246 in the BA-MPE vs.
other	36421385	hsa-mir-10a	Teratozoospermia	3p) did not significantly differ between the study and control groups.
genetics_knock down_promote	36420764	hsa-mir-1245b	Uterine Cervical Neoplasms	AATBC showed a significant prognostic value and miR-1245b-5p was found to mediate the tumor inhibitory effect of AATBC knockdown, which is speculated to be the underlying molecular mechanism of AATBC in cervical cancer development.
lncRNA target	36420706	hsa-mir-497	Breast Neoplasms	5p could improve the treatment response to paclitaxel in patients with breast cancer by inhibiting MALAT1 and SHOC2.
other	36420648	hsa-mir-146a	Arthritis, Rheumatoid	This study successfully predicted that LCK, FOXC1 and hsa-miR-146a-5p can be used as potential immune effector molecules of RA.
other	36420078	hsa-mir-455	Lung Neoplasms	LINC01635, a long non-coding RNA with a cancer/testis expression pattern, promotes lung cancer progression by sponging miR-455-5p.
circulation_biomarker_diagnosis_up	36419391	hsa-mir-367	Carcinoma, Non-Small-Cell Lung	3p in cancer tissues of 22 NSCLC patients was lower than corresponding normal tissues (P<0.05), and the serum miR
other	36419192	hsa-mir-342	Colitis, Ulcerative	3p-IRAK3 axes were found as potential regulatory pathways in UC.
other	36419192	hsa-mir-650	Colitis, Ulcerative	3p-IRAK3 axes were found as potential regulatory pathways in UC.
circulation_biomarker_diagnosis_ns	36418932	hsa-mir-124	Lupus Nephritis	RESULTS: HOXA11-OS was highly expressed in LN tissues, serum, and cells, and the expression of some key autophagy factors and Cyr61 was significantly increased, while miR
lncRNA target	36418889	hsa-mir-203	Ataxia Neuropathy Spectrum	Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2.
lncRNA target	36418889	hsa-mir-200	Cleft Palate	Thus, targeting of the ZEB2-miR-200 axis by TBX1 may have potential therapeutic implications in miRassociated tumors and cleft palate.
lncRNA target	36418889	hsa-mir-200	Ataxia Neuropathy Spectrum	Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2.
lncRNA target	36418889	hsa-mir-200b	Ataxia Neuropathy Spectrum	TBX1 rescues ZEB2-dependent transcriptional inhibition of the miR-200b/200a/429 cluster, whose promoter region contains conserved overlapping cis-regulatory motifs of the ZEB-binding E-box and TBX-binding element.
transcription factor target	36418472	hsa-mir-199	Melanoma, Experimental	5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance.
transcription factor target	36418472	hsa-mir-204	Melanoma, Experimental	5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance.
lncRNA target	36418471	hsa-mir-1231	Colorectal Neoplasms	Mechanistically, circTDRD3 promoted HIF1alpha expression by sponging miR-1231, which facilitated CRC progression. Our findings reveal that circTDRD3 facilitates the proliferation and metastasis of CRC through a positive feedback loop mediated by the HIF1alpha/PTBP1/circTDRD3/miR-1231/HIF1alpha axis.
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-23b	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-191	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-92a	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
lncRNA target	36417821	hsa-mir-217	Acute Lung Injury	CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR
lncRNA target	36417821	hsa-mir-217	Sepsis	CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR
genetics_knock down_suppress	36417034	hsa-mir-214	Atrial Fibrillation	In conclusions, circCAMTA1 knockdown alleviated atrial fibrosis through downregulating TGFBR1 expression intermediated by miR
genetics_knock down_promote	36416408	hsa-mir-1225	Carcinoma, Non-Small-Cell Lung	5p recuperated the effects of circ_0075048 knockdown on NSCLC progression.
genetics_overexpression_promote	36416387	hsa-mir-23a	Pancreatic Carcinoma	HK-2 overexpression exerted oncogenic effects on pancreatic cancer cells and promoted cellular glycolysis; more importantly, HK-2 overexpression partially eliminated the effects of miR-323a overexpression.
other	36415802	hsa-mir-129	Myocardial Reperfusion Injury	5p.
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-373	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-21	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-155	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
genetics_knock down_promote	36415199	hsa-mir-181a	Osteosarcoma	However, knockdown miR-181a-5p promoted the proliferation and migration of osteosarcoma HOS cells, the cells in S phase increased(P<0.05).
lncRNA target	36414916	hsa-let-7c	Glioma	However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma.
other	36414911	hsa-mir-204	Depression	Notably, pre-ECT miR-204 levels moderately positively correlated with depression severity at baseline and moderately negatively correlated with mood score reduction post-ECT.
circulation_biomarker_diagnosis_ns	36414650	hsa-mir-144	COVID-19	Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR
other	36414609	hsa-mir-25	Hypertension	3p expression could aid HDIP diagnosis, and associated with an increased risk of adverse pregnancy outcomes in PE patients.
other	36414112	hsa-mir-34	Neurotic Disorders	RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype.
other	36414112	hsa-mir-34a	Neurotic Disorders	RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype.
transcription factor target	36414029	hsa-mir-122	Myocardial Infarction	The current study aims to investigate the cardioprotective effects of xanthenone through targeting the miR-122/Sirt-6/ACE2 axis on experimentally-induced MI in rats. Finally, by targeting the miR-122/Sirt-6/AMPK/ACE2 axis, xanthenone has the potential to be a promising cardioprotective agent against MI.
other	36413508	hsa-mir-24	Aortic Aneurysm, Abdominal	This study shows for the first time that inhaled e-cig nicotine vapor augments experimental AAA and aortic inflammation, suggests a mechanistic role for the cytokine Chil1/CHI3L1 and its regulator microRNA-24, and raises red flags regarding longitudinal e-cig safety.
transcription factor target	36413378	hsa-mir-382	Osteoarthritis	Our findings revealed that EVs produced by the OA rats contained miR5p, which might reduce cell viability and proliferation, and promote cell apoptosis by targeting PTEN.
circRNA target	36413177	hsa-mir-940	Keloid	CONCLUSIONS: This study suggests that hsa_circ_0038382 attenuates keloid formation by regulating the miR-940/TBX5 axis, which might provide a potential therapeutic target in the treatment of keloid formation.
genetics_knock down_promote	36412985	hsa-mir-133b	Esophageal Squamous Cell Carcinoma	NCK1-AS1 knockdown or miR-133b overexpression inhibited the malignant properties of ESCC cells as well as tumorigenesis in vivo.
circulation_biomarker_diagnosis_ns	36412588	hsa-mir-21	Breast Neoplasms	With the proposed method, the expression of miR-21 in different cancer cells can be assessed, and breast cancer patients and healthy individuals can be differentiated by analyzing the target miRNAs extracted from serum samples, holding great potential in clinical diagnosis.
transcription factor target	36412002	hsa-mir-21	Adenocarcinoma of Lung	QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro.
transcription factor target	36412002	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro.
circulation_biomarker_diagnosis_ns	36411886	hsa-mir-122	Carcinoma, Hepatocellular	Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin.
circulation_biomarker_diagnosis_ns	36411886	hsa-mir-122	Diabetes Mellitus, Type 2	Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin.
genetics_GWAS	36411728	hsa-mir-124-1	Zika virus congenital syndrome	We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR
genetics_GWAS	36411728	hsa-mir-124	Zika virus congenital syndrome	We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR
other	36411682	hsa-mir-145	Acute Kidney Injury	mediated autophagy.
other	36411682	hsa-mir-145	Reperfusion Injury	mediated autophagy.
lncRNA target	36411681	hsa-mir-200b	Liver Neoplasms	CONCLUSIONS: MiR-200b is involved in hepatocellular carcinoma progression via targeting SMYD2 and regulating SMYD2/p53/CyclinE1 signaling pathway and may be used as a potential target for hepatocellular carcinoma treatment.
other	36411517	hsa-mir-338	Prostatic Neoplasms	has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway.
genetics_GWAS	36411451	hsa-mir-218	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Epigenetically, the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 expression was decreased in patients with CML. Furthermore, SLIT2 promoter methylation may function by regulating the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 during CML progression.
transcription factor target	36410437	hsa-mir-150	Prostatic Neoplasms	Additionally, profiling of MYB-targeted miRNAs demonstrated significant induction of miR-150 in high-dose androgen-treated PCa cells. Furthermore, MYB-silencing or miR-150 mimic transfection suppressed PCa cell growth induced by low-dose androgen, whereas miR-150 inhibition rescued PCa cells from growth repression by high-dose androgen.
other	36410410	hsa-mir-20b	Schizophrenia	SIGNIFICANCE: The significant SCZ-related ceRNAs subnetworks (lncRNA-C2orf48A/hsa-miR-20b-5p,5p/KIF23, FOXJ2) may represent promising predictive and diagnostic biomarkers and provide novel insights into the mechanism by which lncRNAs act as microRNA sponges and contribute to the pathogenesis of SCZ.
lncRNA target	36410171	hsa-mir-365a	Colorectal Neoplasms	RESULTS: In clinical samples and CRC cells, the abundance of HCG18 was enhanced whereas miR-365a-3p was reduced. CONCLUSION: Our results revealed that HCG18 promoted M2 macrophage polarization to facilitate CET resistance to CRC cells through modulating miR-365a-3p/FOXO1/CSF-1 axis.
other	36410106	hsa-mir-516b	Glioblastoma	Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G).
other	36410106	hsa-mir-516a	Glioblastoma	Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G).
transcription factor target	36410068	hsa-mir-375	Fatty Liver	This study uniquely revealed that miR-375 induced lipid synthesis and inhibited cell proliferation may partly due to regulation of RBPJ expression, thereby involving in fatty liver formation and inheritance in chicken.
circRNA target	36409529	hsa-mir-188	Pneumonia, Mycoplasma	3p, thereby inhibiting trophoblast cells function, which suggested a new molecular mechanism for the pathogenesis of PE.
exosome	36409397	hsa-mir-1	Adenocarcinoma of Lung	CONCLUSIONS: The promoting effect of IH on LUAD is achieved partly through BMSCs-derived exosomal miR
other	36408612	hsa-mir-454	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
other	36408612	hsa-mir-26b	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
other	36408612	hsa-mir-584	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
lncRNA target	36408278	hsa-mir-155	Neurogenic Inflammation	Thus, BA suppressed the LPS-stimulated neuroinflammation in BV-2 microglia by blocking the TLR4-mediated signal transduction through TLR4/MyD88/NF-kappaB and MAPK pathways and inhibiting the miR-155 expression.
lncRNA target	36407085	hsa-mir-135b	Colonic Neoplasms	Moreover, the effects of hsa-miR-135b-5p on the biological behavior of COAD cells were observed. Therefore, downregulation of hsa-miR-135b-5p inhibits cell proliferation, migration, and invasion in COAD, and carcinogenesis may function by targeting FOXN2, NSA2, MYCBP, DIRAS2, DESI1, and RAB33B.
circulation_biomarker_diagnosis_ns	36406766	hsa-mir-182	Schizophrenia	On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis.
circulation_biomarker_diagnosis_ns	36406766	hsa-mir-183	Schizophrenia	On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis.
lncRNA target	36406317	hsa-mir-203a	Carcinoma, Hepatocellular	RESULTS: MiR-203a was significantly down-regulated in HBsAg-positive HCC with the sharpest decrease shown in microarray analysis. miR-203a may serve as a crucial treatment target in HBsAg-positive HCC.
lncRNA target	36406123	hsa-mir-190a	Ovarian Failure, Premature 	In conclusion, miRNA-190a-5p may become a potential biomarker for early screening of POF, and it can continuously activate primordial follicles in rats by targeting the expression of PHLPP1 and key proteins in the AKT-FOXO3a and AKT-LH/LHR pathways.
other	36406123	hsa-mir-151	Ovarian Failure, Premature 	5p.
other	36406123	hsa-mir-27b	Ovarian Failure, Premature 	5p.
other	36405735	hsa-mir-663a	Stomach Neoplasms	An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis.
other	36405735	hsa-mir-135a	Stomach Neoplasms	An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis.
transcription factor target	36405246	hsa-mir-524	Colonic Neoplasms	5p/CXCR7 axis regulated angiogenesis in colon cancer cells through the AKT and ERK pathways.
circulation_biomarker_diagnosis_down	36404826	hsa-mir-20a	Diabetes Mellitus, Type 2	METHODS: In the present study, we checked the expression of miR-320a, 182-5p, 503, and 375 by using quantitative PCR in both stimulated and unstimulated saliva and blood samples of 40 adult patients with type-2 diabetes compared to 40 healthy individuals.
genetics_knock down_promote	36404720	hsa-mir-885	Prostatic Neoplasms	5p, thereby blocking the effect of HOXA-AS2 knockdown by the miR
lncRNA target	36403772	hsa-mir-222	Prostatic Hyperplasia	Our findings elucidate that the pseudogene/lncRNA-hsa-miR3p-XBP1 pathway may play a regulatory role in the occurrence of BPH through autophagy.
lncRNA target	36403324	hsa-mir-29a	Tendon Injuries	Here, microRNA29a is identified as a promising therapeutic target for tendon injury through the cross-regulation of the immune response and matrix remodeling. In vivo studies of the Achilles tendon-rupture model indicate the best repair in the miR29a group, as evidenced by superior collagen composition and alignment, higher mechanical strength, and better functional recovery.
genetics_overexpression_suppress	36403222	hsa-mir-205	Influenza, Human	5p overexpression-induced inhibition of influenza A replication could be attributed to the inhibition of NP expression.
circRNA target	36403044	hsa-mir-27a	Hypertension, Pulmonary	CONCLUSION: Our findings demonstrated that circGSAP alleviated the dysfunction of PMECs via the increase of BMPR2 by competitively binding with miR-27a-3p, and mitigated pulmonary vascular remodeling of MCT-PH rats, providing potential therapeutic strategies for IPAH.
other	36401723	hsa-mir-217	Uterine Cervical Neoplasms	As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy.
other	36401723	hsa-mir-140	Uterine Cervical Neoplasms	As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy.
exosome	36401721	hsa-mir-506	Colorectal Neoplasms	The goal of the research was to study into the role of exosomal-miR
transcription factor target	36401720	hsa-mir-144	Necrobiotic Disorders	Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment.
transcription factor target	36401720	hsa-mir-144	Fibrosis	Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment.
other	36401685	hsa-mir-34a	Osteosarcoma	LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway.
other	36401491	hsa-mir-144	Urologic Neoplasms	Low miR-144 expression had better predictive value in patients with urinary system cancer (HR: 0.48, 95% CI: 0.35-0.64).
other	36401446	hsa-mir-34a	Pulmonary Disease, Chronic Obstructive	In conclusion, Res attenuated CSE-induced cellular senescence in BEAS-2B cells by regulating the miR-34a/SIRT1/NF-kappaB pathway, which may provide a new approach for COPD treatment.
genetics_GWAS	36401419	hsa-mir-146a	Coronary Disease	MicroRNA (miRNA)-146a rs2910164, a single nucleotide polymorphism, is associated with the progression of CHD risk.
lncRNA target	36401368	hsa-mir-200c	Breast Neoplasms	Collectively, baicalin significantly suppresses cell viability, migration, and invasion of BC cells possibly by regulating the TGF-beta/lncRNA-MALAT1/miR-200c pathway.
genetics_overexpression_promote	36401052	hsa-mir-421	Parkinson Disease	Overexpressed SNHG8 downregulates miR
lncRNA target	36400758	hsa-mir-202	Cholangiocarcinoma	Mechanistically, linc00976 competitively interacted with miR-3202 to upregulate GPX4 expression, thus contributing to the malignant biological behavior of CCA cells. Accordingly, JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating CCA tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis.
circulation_biomarker_diagnosis_up	36400592	hsa-mir-155	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
circulation_biomarker_diagnosis_up	36400592	hsa-mir-21	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
circulation_biomarker_diagnosis_up	36400592	hsa-mir-223	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
lncRNA target	36399797	hsa-mir-485	Carcinoma, Ovarian Epithelial	CONCLUSION: SNHG17 silencing inhibits the development of EOC via regulation of miR
lncRNA target	36399659	hsa-mir-16b	Staphylococcal Infections	aureus-induced inflammation via microRNA-16b/YAP1-mediated regulation, and these findings might provide a new strategy for the prevention of bovine mastitis, facilitating further studies good of zoonotic diseases caused by S.
genetics_overexpression_promote	36399467	hsa-mir-34a	Melanoma	CONCLUSION: Melanoma cells overexpressed KCNQ1OT1, which influenced the miR-34a/STAT3 axis, to promote proliferation, migration, and invasion of melanoma cells.
transcription factor target	36399285	hsa-mir-106b	Leukemia, Myeloid	We also showed that inhibitors of the miR-106b-25 cluster and BCL-2 exert synergistic effects on apoptosis induction in primary myeloid leukaemic cells. Thus, the members of the miR-106b-25 cluster may jointly contribute to myeloid leukaemia drug resistance by inactivating multiple apoptotic genes.
other	36398728	hsa-mir-193a	Stomach Neoplasms	LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation.
other	36398319	hsa-mir-15b	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
other	36398319	hsa-mir-374a	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
other	36398319	hsa-mir-106a	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
exosome	36398229	hsa-mir-665	Osteosarcoma	CONCLUSION: This work proved that exosomes loaded with miR-665 inhibited the progression of OS in vivo and in vitro in a safe manner.
exosome	36398226	hsa-mir-382	Sepsis	CONCLUSION: EPC-derived exosomal miR
other	36398070	hsa-mir-200b	Pterygium	The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs.
other	36398070	hsa-mir-1	Pterygium	We found that hsa_circ_0002406 might upregulate FN1 and ADAM12 by sponging miR-26b-5p and miR3p, respectively, thus promoting EMT in pterygium.
other	36398070	hsa-mir-203a	Pterygium	The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs.
other	36398067	hsa-mir-148a	Carcinoma, Hepatocellular	In general, our data provided evidence that HCG18/hsa-mir-148a-regulated high expression of LAYN is associated with immune cell infiltration and unfavorable prognosis of LIHC patients.
lncRNA target	36397699	hsa-mir-361	Hyalinosis, Systemic	CONCLUSION: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m6A-dependent manner through miR
lncRNA target	36397308	hsa-mir-1272	Colorectal Neoplasms	CONCLUSION: Circ_0006508-mediated miR-1272 inhibition could promote the malignant behaviors of colorectal cancer with an upregulated Warburg effect.
other	36397164	hsa-mir-1208	Glioblastoma	The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression.
transcription factor target	36396820	hsa-mir-361	Colorectal Neoplasms	nucleatum-infected CRC via the MYC/miR5p/sonic hedgehog pathway cascade, subsequently reversing stemness and abolishing F.
exosome	36396777	hsa-mir-376c	Osteoarthritis	Meanwhile, the in vivo experiments also corroborated that the miR-376c-3p in hADSC-derived Exos mitigated OA-induced chondrocyte degradation and synovial fibrosis. MiR-376c-3p in hADSC-derived Exos repressed the WNT-beta-catenin pathway by targeting WNT3 or WNT9a, and then mitigating OA-induced chondrocyte degradation and synovial fibrosis, thereby providing theoretical basis for clinical implementation of treatment.
genetics_knock down_promote	36396668	hsa-mir-548l	Neuroblastoma	We also found that miR-548l overexpression suppressed cell viability and promoted apoptosis, while miR-548l knockdown promoted cell viability and inhibited apoptosis in neuroblastoma cells.
transcription factor target	36396627	hsa-mir-760	Urinary Bladder Neoplasms	Together, we concluded a regulatory axis composed of METTL1/m(7)G/miR-760/ATF3 in regulating BCa progression and provided potential therapeutic targets for BCa.
exosome	36396626	hsa-mir-769	Oculodigitoesophagoduodenal syndrome	5p to be loaded into extracellular vesicles (EVs) and to promote MMT reversal in recipient mesenchymal-like MCs.
other	36396626	hsa-mir-769	Fibrosis	In conclusion, we highlighted an HDAC1-WT1-miR5p axis potentially relevant for therapies aimed at counteracting organ fibrosis.
genetics_knock down_promote	36396591	hsa-mir-1297	salivary gland adenoid cystic carcinoma	STUDY DESIGN: The expression of long non-coding RNA human leukocyte antigen complex group 11 (HCG11), microRNA-1297 (miR-1297), and EphA2 in SACC cell lines compared with normal human salivary gland (HSG) cell line was measured by reverse transcription-quantitative polymerase chain reaction.
other	36396240	hsa-mir-141	Prostatic Neoplasms	The latest research shows that the expression level of microRNA-141 can predict the number of prostate cancer cells in the human body and has become an important biomarker. In this paper, an all-carbon sandwich self-powered biosensor based on graphene and carbon cloth is constructed for the highly sensitive detection of the prostate tumor marker miRNA-141.
other	36394782	hsa-mir-1246	Breast Neoplasms	MiR-1246 has recently gained much attention and many studies have shown its oncogenic role in colorectal, breast, lung, and ovarian cancers.
genetics_overexpression_promote	36394255	hsa-mir-326	Thyroid Cancer, Papillary	Additionally, miR-326 was a downstream target of circ_0003892, and miR-326 overexpression weakened the promoting effect of circ_0003892 overexpression on the malignant progression of PTC.
other	36394070	hsa-mir-148a	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394070	hsa-mir-486	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394070	hsa-mir-744	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394065	hsa-mir-142	Adenocarcinoma of Lung	3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients.
other	36389659	hsa-mir-146	Neurogenic Inflammation	Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation.
other	36389659	hsa-mir-146a	Neurogenic Inflammation	Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation.
genetics_knock down_promote	36389659	hsa-mir-146b	Neurogenic Inflammation	Our experiments demonstrated that miR-146b deficiency results in the attenuation of LPS-induced neuroinflammation, as it was evidenced by the reduction of sickness behavior, a decrease in the inflammatory status of microglia, and the loss of morphological signs of microglial activation in the hippocampus.
lncRNA target	36389338	hsa-mir-491	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LncRNA KCNQ1OT1 was associated with the radioresistance of radioresistant LUSC cells, and the lncRNA KCNQ1OT1/miR5p/TPX2-RNF2 axis might be used as a therapeutic target to enhance the radiosensitivity of radioresistant LUSC cells.
transcription factor target	36389185	hsa-mir-29a	Tuberculosis, Pulmonary	The upregulation of miRNA-29a-3p suppresses the immune response by post-transcriptionally inhibiting interferon (INF)- expression in T cells, increasing susceptibility to pulmonary TB.
tissue_expression_ns	36388982	hsa-mir-17	Thymic aplasia	We demonstrate that transgenic miR-17 approximately 92 cell-intrinsically largely overcomes defects caused by CD28 deficiency.
other	36388689	hsa-mir-200b	Stomach Neoplasms	Interfering HMGB3 release from cancer-associated fibroblasts by miR-200b represses chemoresistance and epithelial-mesenchymal transition of gastric cancer cells.
circulation_biomarker_prognosis_down	36388649	hsa-mir-375	Esophageal Squamous Cell Carcinoma	RESULTS: miR-375 expression was significantly downregulated in both ESCC clinical tissues and serum, and the reduction of miR-375 was remarkably linked to a poor prognosis in ESCC.
exosome	36388165	hsa-mir-4455	Glomerulonephritis, IGA	This study revealed that MC-derived exosomal miR-4455 is a key factor affecting podocyte injury and provides a series of potential therapeutic targets for treating IgA nephropathy.
target gene	36388045	hsa-mir-137	Carcinoma, Non-Small-Cell Lung	miR-137 represses migration and cell motility by targeting COX-2 in non-small cell lung cancer.
other	36387469	hsa-mir-21	Adenocarcinoma of Lung	Finally, we discovered that the lncRNA MIR17HG/AC009299.3/miR5p/CCL20 regulatory network might be crucial in the pathogenesis of LUAD.
epigenetics	36387263	hsa-mir-1	Prostatic Neoplasms	3p expression by promoter hypermethylation.
lncRNA target	36387210	hsa-mir-628	Triple Negative Breast Neoplasms	This study demonstrated the vital roles of WFDC21P and its m6A in regulating the proliferation and metastasis of TNBC cells via the WFDC21P/miR-628/SMAD3 axis.
target gene	36387162	hsa-mir-134	Melanoma	Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma.
lncRNA target	36387061	hsa-mir-1249	Osteosarcoma	CONCLUSIONS: Our study uncovered the cancer-promoting role of LINC00665 in OS, and the feedback loop of LINC00665/miR5p/WNT2B/Wnt might be a potential target for OS treatment.
circulation_biomarker_prognosis_up	36386576	hsa-mir-10a	Pneumonia	RESULTS: Compared with healthy control, serum miR-10a-3p expression in patients with severe pneumonia was distinctly upregulated (P < 0.001).
other	36385489	hsa-mir-875	Carcinoma, Hepatocellular	YY1-activated LINC01608 could promote HCC progression by associating with miR5p to induce the EGFR/ERK signalling pathway.
other	36385302	hsa-mir-218	Alopecia	miR-218 has therapeutic potential for alopecia since it can activate the Wnt/beta-catenin channel by down-regulating SFRP2, which is a key channel in hair follicle cycle transformation for hair regrowth.
lncRNA target	36385135	hsa-mir-574	Colorectal Neoplasms	Our results suggested that NALT1 promoted CRC proliferation and migration by sponging miRNA5p to upregulate PEG10 expression, and implied that NALT1 might act as a promising biomarker and therapeutic target for CRC.
lncRNA target	36384413	hsa-mir-29c	Nerve Degeneration	SNHG15 served as a sponge to down-regulate miR-29c-3p, thereby releasing the inhibition of miR-29c-3p on SNCA expression, which promoted neuronal damages upon MPP(+) challenge. CONCLUSION: The upregulation of SNHG15 upon MPP(+) challenge mediates neuronal damages in SK-N-SH cells by regulating miR-29c-3p/SNCA axis.
lncRNA target	36384265	hsa-mir-214	Cardiomyopathies	3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis.
lncRNA target	36384265	hsa-mir-214	Sepsis	3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis.
transcription factor target	36384170	hsa-mir-155-1	Distal myopathy, Nonaka type	1 could act as a positive factor for virus replication in DEFs, which inhibited type I interferon (IFN-I) production.
genetics_overexpression_suppress	36384115	hsa-mir-145	Sucrase-isomaltase deficiency, congenital	5p overexpression.
other	36383327	hsa-mir-744	Multiple Sclerosis	5p is recommended as an important biomarker for the development together of diabetes mellitus, Alzheimer's disease, and MS disease.
circRNA target	36382967	hsa-mir-584	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ_0079530 promoted NSCLC progression by regulating the miR5p/THBS2 axis, providing a possible circRNA-targeted therapy for NSCLC.
lncRNA target	36382488	hsa-mir-137	Glioma	CONCLUSIONS: It was found that miR-137 could target E2F7 to restrain cell progression and accelerate programmed cell death of glioma cells, which is helpful to search for new molecular therapeutic targets for glioma.
lncRNA target	36382487	hsa-mir-27b	Glioma	CONCLUSIONS: Silencing LINC01128 inhibited the proliferation, migration, and invasion levels of glioma cells by targeting miR-27b-3p, thereby affecting the progression of gliomas.
lncRNA target	36381992	hsa-mir-92b	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381992	hsa-mir-374b	Pulmonary Disease, Chronic Obstructive	RESULTS: One miRNA was significantly dysregulated between moderate GOLD participants compared to severe/very severe GOLD participants, with an AUC of 0.798, p = 0.01 for miR-374b-5p.
lncRNA target	36381992	hsa-mir-223	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381992	hsa-mir-374a	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381675	hsa-mir-27a	Colonic Neoplasms	CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU.
lncRNA target	36381675	hsa-mir-27	Colonic Neoplasms	CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU.
other	36381642	hsa-mir-595	Coronary Artery Disease	In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression.
other	36381642	hsa-mir-24	Coronary Artery Disease	In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression.
lncRNA target	36381585	hsa-mir-142a	Peripheral Nerve Injuries	Together, these results suggest that miR-142a-3p may be a potential target for therapeutic intervention to prevent motor endplate degradation following peripheral nerve injury.
target gene	36381334	hsa-mir-122	Prostatic Neoplasms	MicroRNA-122 targets delta-catenin to suppress the tumorigenic potential of prostate cancer cells.
genetics_GWAS	36381329	hsa-mir-99b	Breast Neoplasms	MiR-99b-high breast cancer was associated with high homologous recombination deficiencies, intratumor heterogeneity, and high rates of mutation and neoantigens.
genetics_GWAS	36381083	hsa-mir-217	Retinoblastoma	3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001).
genetics_GWAS	36381083	hsa-mir-592	Retinoblastoma	3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001).
other	36380872	hsa-mir-369	Thyroid Neoplasms	lncRNA EGFEM1P promotes thyroid cancer progression by acting as an miR-369-3p sponge and upregulating TCF4.
genetics_knock down_promote	36380666	hsa-mir-38	Nasopharyngeal Carcinoma	3p targeted and negatively regulated ELAVL1; ELAVL1 overexpression affected the effects of miR
lncRNA target	36380665	hsa-mir-21	Colorectal Neoplasms	Methods: The colorectal carcinoma (CRC) cell HCT116 was divided into blank control, negative control (NC), si-GAS5 and si-GAS5+ miR-21 inhibitor groups. Conclusion: GAS5 can act as a competing endogenous RNA for miR-21, and down regulation of GAS5 can promote the development of CRC by activating the miR-21/PTEN/Akt signaling pathway and promoting the acquisition of EMT and tumor cell stemness.
other	36380664	hsa-mir-503	Esophageal Squamous Cell Carcinoma	The xenograft experiment showed that the subcutaneous tumor in shMIR503HG group was significantly smaller than that in shNC group, and the tumor weight in shMIR503HG group was (0.097+/-0.026) g, which was lower than (0.166+/-0.021) g in shNC group (P<0.001).
circulation_biomarker_diagnosis_ns	36380587	hsa-mir-126	Neoplasms, Vascular Tissue	In a validated experimental model of lethal murine vascular neoplasm, tumor-originating EV delivered its miR-126 cargo to tumor-associated macrophages (TAMs).
genetics_overexpression_promote	36380260	hsa-mir-125b	Carcinoma, Endometrioid	Besides, the promoting impact of MTFP1 overexpression on malignant phenotypes of EC cells could be restored by miR-125b-5p up-regulation.
circRNA target	36380035	hsa-mir-873	Carcinoma, Hepatocellular	5p directly targeted the 3' untranslated region (3'UTR) of PHF2, and PHF2 was negatively regulated by miR
lncRNA target	36379611	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	In our previous work, we reported that the targeted expression of microRNA-7 (miR-7) operated by thyroid transcription factor-1 (TTF-1) promoter inhibited the growth of human lung cancer cells in vitro and in vivo; however, the intervention efficiency needed to be further improved. On the whole, our study revealed that the optimized TTF-1 promoter could more effectively operate miR-7 to influence the growth of human NSCLC cells, providing a new basis for the development of microRNA-based targeting gene therapy against clinical lung cancer.
other	36379393	hsa-mir-146a	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379393	hsa-mir-23a	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379393	hsa-mir-652	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379214	hsa-mir-124	Bipolar Disorder	3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP.
other	36379214	hsa-mir-124	Schizophrenia	3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP.
other	36378391	hsa-mir-488	Epilepsy	LncRNA PVT1 Promotes Neuronal Cell Apoptosis and Neuroinflammation by Regulating miR-488-3p/FOXD3/SCN2A Axis in Epilepsy.
other	36378340	hsa-mir-1914	Ovarian Neoplasms	We hypothesize that mir-1914 might open a new line of research in the realm of managing the recurrence of OC and could be a significant factor in triggering OC recurrence.
genetics_overexpression_promote	36377304	hsa-mir-199b	Carcinoma, Hepatocellular	Overexpressed miR-199b-3p constrained HCC cell proliferation, migration, and invasion while fostering apoptosis, which could be counteracted by upregulating AURKA.
other	36377220	hsa-mir-503	Endometriosis	Poly lactic-co-glycolic-based NPs were used as vector carriers for miRNA 503 transfection in endometriosis cells.
transcription factor target	36377217	hsa-mir-140	Pneumonia	CONCLUSION: In ASMCs, miR3p can inhibit the JAK2/STAT3 signaling pathway by targeting HMGB1, thus ameliorating airway inflammation and remodeling in the pathogenesis of asthma.
circulation_biomarker_diagnosis_ns	36377217	hsa-mir-140	Asthma	3p expression was declined in asthmatic patients' plasma and ASMCs stimulated by PDGF-BB.
lncRNA target	36377216	hsa-mir-18a	Colorectal Neoplasms	CONCLUSION: CASC2 inhibits CRC development by suppressing miR-18a-5p and raising BTG3 expression.
other	36376850	hsa-mir-509	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-421	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-769	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-42	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-296	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-193a	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-139	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-767	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
lncRNA target	36376845	hsa-mir-340	Liver Cirrhosis, Hepatitis Virus B-Related	5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC.
lncRNA target	36376845	hsa-mir-20a	Liver Cirrhosis, Hepatitis Virus B-Related	5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC.
epigenetics	36376550	hsa-mir-29c	Lung Neoplasms	CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis.
other	36375570	hsa-mir-145	Breast Neoplasms	KEY FINDINGS: Based on bioinformatics analyses, CCAT2, AKT3, and mTOR were up-regulated in breast cancer cell lines, tissues, and TAM-resistant cells, while hsa-miR5p was down-regulated.
transcription factor target	36375474	hsa-mir-570	Colorectal Neoplasms	CONCLUSIONS: The present study reveals that ZnC slows the progression of CRC by inhibiting CRC cells in terms of proliferation, invasion and migration, meanwhile up-regulating PD-L1 expression via inhibiting miR-570.
virus_miRNA	36374933	bkv-mir-B1	Kidney Transplantation	Urine exosomal bkv-miR-B1-5p was associated with BKVN as were urine and plasma BKV DNA loads on serial follow-up, and might have potential as a predictive marker for BKVN during the early post-transplant period.
lncRNA target	36374810	hsa-mir-3677	Uterine Cervical Neoplasms	TRAF3IP2-AS1 may play a tumor-suppressor role in cervical cancer progression by sponging miR
other	36374808	hsa-mir-148b	Carotid Stenosis	Pearson analysis was used to analyze the relationship between HOTAIR and miR-148b-3p in patients with CAS. Reduction of miR-148b-3p expression was substantiated in CAS patients.
other	36374807	hsa-mir-130a	Thyroid Neoplasms	TYMSOS and myristoylated alanine rich protein kinase C substrate like 1 (MARCKSL1) were upregulated whereas miR-130a-5p was downregulated in THCA cells and tissues. Collectively, TYMSOS facilitates THCA progression by sponging miR-130a-5p and upregulating MARCKSL1 to activate the PI3K/Akt signaling pathway, providing new avenues for THCA treatment.
transcription factor target	36374798	hsa-mir-424	Carcinoma, Hepatocellular	Therefore, ultrasound-mediated targeted NBs are a potential effective carrier for liver cancer, and PD-L1 antibody and miR-424 have a synergistic anti-tumor immunotherapy effect.
other	36374774	hsa-mir-32	Colorectal Neoplasms	Meanwhile, we found that the transcription factor SP1 activated PROX1-AS1/miR-32/FBXL20 axis, thereby promoting CRC progression.
other	36374443	hsa-mir-497	Urinary Bladder Neoplasms	RESULTS: CEP55 expression as well as the expression levels of the oncogenic proteins PTHLH and HMGA2 were upregulated in BC cells while miR5p was downregulated.
genetics_GWAS	36374407	hsa-mir-495	Large-Artery   Atherosclerosis Stroke	MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.
genetics_GWAS	36374407	hsa-mir-200b	Large-Artery   Atherosclerosis Stroke	MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.
transcription factor target	36374403	hsa-mir-23a	Colonic Neoplasms	This study demonstrated the mechanism of miR-23a-3p in CC, which may offer a new target for CC therapy.
other	36374119	hsa-mir-143	Urinary Bladder Neoplasms	Besides, miR-143 is a promising candidate biomarker for diagnosing BCa.
lncRNA target	36372373	hsa-mir-140	Ischemic Stroke	3p directly targets Tyro3 to regulate cell viability and apoptosis of OGD/R-exposed N2a cells through the PI3K/Akt pathway, suggesting that miR
genetics_knock down_promote	36371782	hsa-mir-1294	Stomach Neoplasms	RESULTS: The levels of hsa_circ_0043691 and PBX3 were upregulated, whereas miR-1294 expression was diminished in GC tissues and cells. CONCLUSION: Hsa_circ_0043691 knockdown repressed GC malignant phenotypes by miR-1294/PBX3 axis, which exhibited a novel therapeutic target for GC treatment.
other	36371775	hsa-mir-4739	Adenocarcinoma of Lung	RESULTS: The expression levels of LINC00511 and PYCR1 in LUAD were downregulated, whereas that of miR-4739 was upregulated. CONCLUSION: This study demonstrates for the first time that LINC00511 aggravates the malignancy of LUAD by sponging miR-4739 to upregulate PYCR1 expression.
genetics_GWAS	36371555	hsa-mir-149	Breast Neoplasms	Therefore, human blood samples and breast cancer cell line (MCF7) were analyzed to study any possible association between the genetic variant (rs2292832) in the miR-149 precursor and breast cancer susceptibility. METHODS: To study the role of rs2292832 polymorphism in breast cancer, the miR-149 gene variant was genotyped using PCR-RFLP.
lncRNA target	36371491	hsa-mir-195	Triple Negative Breast Neoplasms	5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application.
genetics_knock down_suppress	36371182	hsa-mir-127	Breast Neoplasms	The knockdown of miR-127 substantially increased, whereas overexpression decreased BC cell proliferation, invasion, and migration.
other	36370665	hsa-mir-326	Colorectal Neoplasms	5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC.
other	36370665	hsa-mir-30	Colorectal Neoplasms	5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC.
lncRNA target	36370637	hsa-mir-146a	Rhinitis, Allergic	Treatment with ESP-B4 relieved AR in rats, and elevated miR-146a-5p in the EVs from the nasal epithelial cells, apparently in relation to effects on helper T cell Th1/Th2 equilibrium. CONCLUSION: Overall, ESP-B4 can promote miR-146a-5p secretion, affect the Th1/Th2 balance of helper T cells, and relieve AR symptoms through Smad3/GATA-3 interaction, thus presenting a potential strategy for AR treatment.
transcription factor target	36370225	hsa-mir-200a	Memory Disorders	Our findings imply that miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for treating T2DM-induced memory dysfunction.
lncRNA target	36369960	hsa-mir-493	Cholangiocarcinoma	5p in EVs.
genetics_overexpression_suppress	36369900	hsa-mir-135b	Ovarian Neoplasms	Circ_0000471 served as a molecular sponge for microRNA-135b-5p (miR-135b-5p), and circ_0000471 overexpression-mediated anti-tumor influences in OC cells were largely reversed by the overexpression of miR-135b-5p.
other	36369887	hsa-mir-99a	Osteoporosis	Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication.
other	36369887	hsa-mir-99a	Osteoporosis-pseudoglioma syndrome	Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication.
circulation_biomarker_diagnosis_up	36369742	hsa-mir-210	Disorders of Sex Development	CONCLUSION: Our study showed a positive association between the presence of atypical genitalia and plasma levels of miR-210 expression in the group of patients with 46,XY DSD of unknown aetiology studied.
other	36369467	hsa-mir-654	Pancreatic Carcinoma	Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR3p sponge, thus promoting the PC malignant process.
circulation_biomarker_diagnosis_up	36369428	hsa-mir-19b	Hypoxia-Ischemia, Brain	The expression of miR-19b-3p and SOX6 in umbilical blood of HIE patients was detected by qRT-PCR assay. MiR-19b-3p expression was once down-regulated, whilst SOX6 expression was up-regulated in HIE patients.
lncRNA target	36368448	hsa-mir-363	Pre-Eclampsia	Furthermore, in vivo experiments noted that RES alleviated placental injury and promoted angiogenesis in rats with PE-like symptoms in vivo by increasing VEGF via promoting miR
lncRNA target	36368065	hsa-mir-144	Myocardial Infarction	After intervening the expression of miR-144 by microinjecting and activating Wnt pathway by an agonist BML-284, we confirmed that up-regulated miR-144 suppressed the expression of angiogenesis-related genes and negatively regulated Wnt pathway, further triggering angiogenesis disorders and cardiac phenotypic malformation.
other	36367679	hsa-mir-34a	Cognition Disorders	"The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4."
other	36367679	hsa-mir-128	Cognition Disorders	"The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4."
lncRNA target	36367621	hsa-mir-17	Colonic Neoplasms	3p regulated CC cell malignant progression, as well as apoptosis by targeting PLCD1.
lncRNA target	36367475	hsa-mir-125b	Ischemic Stroke	MSC-EVs inhibit astrocyte activation and associated inflammation through miR-125b-5p/TLR4/NF-kappaB pathway.
lncRNA target	36366842	hsa-mir-6938	Stomach Neoplasms	CONCLUSION: Taken together, our findings demonstrated that circSNTB2 plays an essential role in gastric cancer by regulating miR5p through G0S2 and PDCD4 genes.
lncRNA target	36366818	hsa-mir-3682	Carcinoma, Hepatocellular	In addition, inhibition of PTEN weakened the anti-migration and anti-stemnesic effects of miR
target gene	36366788	hsa-mir-151a	Colorectal Neoplasms	miR-30d-5p and miR-151a-3p, altered in CRC tissue, were also dysregulated in stool of CRC patients and urine of BC cases, respectively.
other	36366542	hsa-let-7f	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-126	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-let-7a	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-122	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-101	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36362375	hsa-mir-101	Carcinoma, Hepatocellular	3p/TKTL1) associated with the progression of HCC under hypoxia.
lncRNA target	36361993	hsa-mir-34a	Colorectal Neoplasms	In conclusion, RF-EMF strongly influenced regulation mediated by the tumour suppressor miR-34a on the peripheral circadian oscillator in DLD1 cells.
lncRNA target	36361979	hsa-mir-1	Fibrosis	5p show the potential to inhibit LEC-dependent fibrosis.
genetics_knock down_suppress	36361843	hsa-mir-143	Obesity	Importantly, during high fat diet-induced obesity, miR-143KO significantly reduced body weight, and improved energy expenditure, insulin sensitivity, and glucose tolerance.
other	36361623	hsa-mir-223	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-21	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-128	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-92a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-92a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-21	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-142	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-26a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-15a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-128	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-142	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-26a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-15a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-223	Genital Diseases, Female	3p and miR-26a-5p.
other	36360309	hsa-mir-1255b	Diabetes Mellitus, Type 2	SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation.
other	36360309	hsa-mir-548o	Diabetes Mellitus, Type 2	SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation.
other	36360258	hsa-mir-203b	Food Hypersensitivity	Logistical regression models revealed that the addition of multi-omic features (miR-203b-3p, Cyanobacteria, and Proteus virus PM135) improved predictiveness for future FRs in infants (p = 0.005, X(2) = 12.9), predicting FRs with 72% accuracy (AUC = 0.81, sensitivity = 72%, specificity = 72%).
transcription factor target	36360255	hsa-mir-431	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-487b	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-432	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-127	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-134	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-23b	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-485	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-382	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-493	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-369	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-34c	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-122	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36359915	hsa-mir-199a	Mastitis	Despite its importance in humans and animals, the molecular mechanism of bovine miR-199a-3p (bta-miR-199a-3p) in dairy cow mastitis and bovine mammary epithelial cell (bMEC) inflammation is unclear. This study reveals the potential regulatory mechanism of bta-miR-199a-3p in bMEC inflammatory immune response and may serve as a useful target for the treatment of mastitis.
lncRNA target	36359915	hsa-mir-199a	Inflammation	Thus, bta-miR-199a-3p inhibits LPS-induced inflammation in bMECs by directly targeting CD2AP and regulating the PI3K/AKT/NF-kappaB signaling pathway.
lncRNA target	36359873	hsa-mir-1264	Chondrosarcoma	Our results indicate that visfatin inhibits miR-1264 production through the PI3K/Akt/mTOR signaling cascade, and thereby promotes PDGF-C expression and chondrosarcoma angiogenesis.
lncRNA target	36359865	hsa-mir-374	Hepatocellular Carcinoma, Hbv-Related	5p/FOXO1 pathway were significantly dysregulated in HCC, and validation in vitro showed that FOXO1 is positively regulated by MAGI2-AS3 through the induction of miR-374a/b-5p in HCC cells.
transcription factor target	36359857	hsa-mir-397	Hepatolenticular Degeneration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-397	Dehydration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-408	Dehydration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-408	Hepatolenticular Degeneration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
exosome	36359855	hsa-mir-140	Diabetes, Gestational	These findings indicate that chemerin reduces placenta-derived exosomal miR
exosome	36359855	hsa-mir-574	Diabetes, Gestational	These findings indicate that chemerin reduces placenta-derived exosomal miR
genetics_overexpression_promote	36359774	hsa-mir-21	Alzheimer Disease	In AD neurons, miR-124/miR-21 overexpression was recapitulated in their exosomes.
circulation_biomarker_diagnosis_ns	36359344	hsa-mir-125b	Hepatitis B, Chronic	This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV).
circulation_biomarker_diagnosis_ns	36359344	hsa-mir-125	Hepatitis B, Chronic	This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV).
other	36358979	hsa-mir-122	Hepatitis C	By complementing miR-122 at the 5' end of the genome, the hepatitis C virus (HCV) gene can form a complex with Argonaute 2 (Ago2) protein to protect the 5' end of HCV RNA from exonucleolytic attacks.
lncRNA target	36357766	hsa-mir-217	Breast Neoplasms	miR-217 repressed sensitivity against anti-cancer drugs by inducing autophagy of BC cells through the NF1/HSF1/ATG7 axis.
lncRNA target	36357715	hsa-mir-125b	Alzheimer Disease 	Altogether, these results indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.
other	36357650	hsa-mir-1225	Uterine Cervical Neoplasms	Collectively, the present study indicates that hsa_circ_0001627 regulates miR5p/FNDC3B/PI3K/mTOR axis and functions as an oncogene in CC progression, suggesting the potential therapeutic use of hsa_circ_0001627 in CC treatment.
genetics_knock down_suppress	36356793	hsa-mir-146a	Epidermodysplasia Verruciformis	Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection. Knockdown of GW182 or Ago2 could weaken the replication ability of exosomal EV71 RNA in recipient cells through decreasing the amount of miR-146a in exosomes, but did not affect the package of viral RNA into exosomes.
exosome	36356793	hsa-mir-146a	Enterovirus Infections	Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection.
circRNA target	36356557	hsa-mir-758	Breast Neoplasms	3p, which might be a novel strategy for breast cancer suppression.
lncRNA target	36356379	hsa-mir-93	Carcinoma, Renal Cell	5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1.
lncRNA target	36356379	hsa-mir-93	Kidney Calculi	5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1.
genetics_overexpression_promote	36356335	hsa-mir-432	Squamous Cell Carcinoma of Head and Neck	5p was inhibited or DNMT3B was overexpressed, the growth and EMT of LSCC cells were stimulated despite ciRS-7 silencing.
other	36355333	hsa-mir-148a	Alzheimer Disease	One of these genes, hsa-miR-148a-3p, might be considered as a new biomarker for Alzheimer's disease diagnosis.
genetics_knock down_promote	36355210	hsa-mir-223	Stomach Neoplasms	3p) in GC cell biology and signaling pathway activation were examined by targeted knockdown (KD) or overexpression (OE) of ECT2 and miR
other	36354672	hsa-mir-130b	Glioblastoma	3p, and -34a-5p not only in the formation of NS, but also in the regulation of malignant growth and invasion of GBM.
genetics_overexpression_promote	36354205	hsa-mir-96	Uterine Cervical Neoplasms	TRIM52-AS1 inhibition or IGF2BP2 overexpression neutralized the inhibition of silencing miR
circulation_biomarker_diagnosis_up	36354186	hsa-mir-3	Spinal Cord Injuries	5p upregulation alleviated the leakage of the blood-spinal cord barrier (BSCB) induced by SCI and improved the neurological functions of SCI rats, as evidenced by the Basso, Beattie, and Bresnahan (BBB) scores and Evans blue staining.
other	36353991	hsa-mir-223	Thyroid Cancer, Papillary	RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA.
other	36353991	hsa-mir-223	Myocardial Infarction	RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA.
transcription factor target	36353937	hsa-mir-550a	Carcinoma, Hepatocellular	In addition, we also found that miR-550a-5p could suppress the growth of HCC in vivo via a xenograft tumor model assay.
circulation_biomarker_prognosis_ns	36353917	hsa-mir-223	Respiratory Distress Syndrome	Thus, circulating MV-miR-223 may be a potential biomarker in prognosticating patient-centered outcomes and predicting mortality in ARDS.
circulation_biomarker_prognosis_up	36353665	hsa-mir-155	Diabetic Foot	CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU.
circulation_biomarker_prognosis_up	36353665	hsa-mir-155	Diabetes Mellitus, Type 2	CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU.
transcription factor target	36353514	hsa-mir-424	Premature Birth	Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR
transcription factor target	36353514	hsa-mir-424	Trophoblast Dysfunction	Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR
transcription factor target	36352829	hsa-mir-543	Parkinson Disease	Our results highlight the idea that dysregulation of miR-543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD.
circRNA target	36352482	hsa-mir-217	Endometrial Neoplasms	hsa_circ_0023404 inhibit miR-217 as sponge which inhibit endometrial cancer cell growth and metastasis.
circulation_biomarker_prognosis_up	36352360	hsa-mir-451	Cholangiocarcinoma	RESULTS: The tissue and serum expression of miR-451 was decreased in cholangiocarcinoma compared with corresponding normal samples.
other	36352275	hsa-mir-423	Glioma	Finally, miR3p's biological functions of in effecting the cell proliferative, migratory, and invasive capabilities of glioma were investigated by performing Cell Counting Kit-8 (CCK-8) and Transwell assays.
lncRNA target	36352177	hsa-let-7a	Glioma	CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis.
lncRNA target	36352177	hsa-mir-29b	Glioma	CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis.
transcription factor target	36352176	hsa-mir-34a	Triple Negative Breast Neoplasms	We found that p53 could inhibit the expression of PD-L1 via miR-34a and that miR-34a could inhibit both cell activity and migration and promoted apoptosis and cytotoxicity in TNBC.
lncRNA target	36352081	hsa-mir-195	Small Cell Lung Carcinoma	5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future.
lncRNA target	36352081	hsa-mir-101	Small Cell Lung Carcinoma	5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future.
other	36351608	hsa-mir-210	Bacterial Infections	At that time, we started research on RNA and bacterial infection and revealed that miR-210, a small RNA in the gastric epithelial cells, is involved in gastric diseases caused by Helicobacter pylori in-fection.
other	36351549	hsa-mir-1	Endothelial Barrier Dysfunction	AGEs induced endothelial cell senescence and endothelial barrier dysfunction by regulating miR3p/MLCK signaling pathway.
other	36351490	hsa-mir-133a	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
other	36351490	hsa-mir-16	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
other	36351490	hsa-mir-133b	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
genetics_GWAS	36350621	hsa-mir-28	Myopia	3p as a novel risk factor for myopia through a genetic association study of the PAX6 gene.
transcription factor target	36350418	hsa-mir-155	ankylosing spondylitis 1	Our primary objective was to explore the role of miR-155 and its targeted factors in AS pathogenesis.
circulation_biomarker_prognosis_ns	36350075	hsa-mir-195	Subarachnoid Hemorrhage	5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients.
circulation_biomarker_prognosis_ns	36350075	hsa-mir-195	Vasospasm, Intracranial	5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients.
other	36349193	hsa-mir-425	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349193	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349193	hsa-mir-7	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349191	hsa-mir-1321	Glioma	In conclusion, our findings showed that oncogene NQO1 and antioncogene miR-1321 bind to oncogene SERPINA1 to affect proliferation and apoptosis of glioma cells, which can bring new solution of antitumor treatments for glioma in the future.
other	36349063	hsa-mir-146b	Heart Injuries	Receiver operating characteristic curve and correlation analysis showed that cTnI and miR-146b had relatively high predictive values for chronic myocardial injury (area under the curve, 0.83 and 0.71, respectively) and were closely correlated with myocardial damage. These data suggested that CK, cTnI and FABP3 were relatively sensitive to DOX-induced acute myocardial injury, whereas cTnI and miR-146b were relatively sensitive to DOX-induced chronic myocardial injury.
other	36348805	hsa-mir-34a	Fibrosis, Renal	Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study.
other	36348805	hsa-mir-34a	Diabetes Mellitus	Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study.
other	36348568	hsa-mir-21	Carcinoma, Hepatocellular	CONCLUSION: miR-21 has a moderate overall performance in diagnosing HCC and may serve as a potential non-invasive marker for this early-stage disease.
other	36348379	hsa-mir-27b	Carcinoma, Hepatocellular	Mechanistically, circRanGAP1 as an oncogene promotes HCC progression by miR-27b-3p/NRAS/ERK axis, furthermore, affects the infiltration level of tumor-associated macrophages probably by sponging miR-27b-3p. CONCLUSION: These results reveal that circRanGAP1 is a HCC oncogene that function by the miR-27b-3p/NRAS/ERK axis and regulates the infiltration levels of tumor-associated macrophages by sponging miR-27b-3p.
lncRNA target	36348305	hsa-mir-145	Colorectal Neoplasms	5p is a tumor suppressor at early stage of CRC, and an oncogene at advanced stage of CRC.
exosome	36348269	hsa-mir-150	Hyperalgesia	CONCLUSION: BMSC-derived exosomal miR
transcription factor target	36348252	hsa-mir-122	Cholangiocarcinoma	5p was found to act as a post-transcriptional regulator of FUT8 and proved to inhibit FUT8 expression and then suppress the proliferation and migration ability of iCCA cell lines.
circulation_biomarker_diagnosis_up	36348199	hsa-mir-559	psoriasis 1	Furthermore, serum miRNA-559 and MTDH displayed comparable diagnostic accuracy in discriminating psoriatic patients from controls.
genetics_overexpression_promote	36348139	hsa-mir-29c	Squamous Cell Carcinoma of Head and Neck	Additionally, overexpressed C1QTNF6 facilitated these biological functions of HNSCC cells while upregulating miR-29c-3p reversed such effect.
other	36348020	hsa-mir-196b	Colorectal Neoplasms	METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b.
lncRNA target	36347825	hsa-mir-138	Laryngeal Neoplasms	5p inhibitor.
lncRNA target	36347300	hsa-mir-26b	Brain Injuries	CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis.
lncRNA target	36347300	hsa-mir-26b	Subarachnoid Hemorrhage	CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis.
other	36346713	hsa-mir-498	Esophageal Neoplasms	Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression
lncRNA target	36346578	hsa-mir-1224	Diabetic Retinopathy	All in all, SPAG5-AS1 attenuates diabetic retinal vascular dysfunction through miR5p/IRS-1 axis, providing a potential therapeutic strategy for DR.
transcription factor target	36345369	hsa-mir-34a	Diabetic Nephropathies	In conclusion, the above data suggested that AIF-1 regulated the levels of inflammation, oxidative stress, and autophagy in HRGECs via miR-34a/ATG4B pathway to contribute to the pathogenesis of diabetic kidney disease.
transcription factor target	36344974	hsa-mir-1199	Prostatic Hyperplasia	5p inhibitor increased SRD5A2 expression in BPH-1 cells.
lncRNA target	36344947	hsa-mir-21	Uterine Cervical Neoplasms	CONCLUSIONS: MEG3 performing as ceRNA promotes cisplatin sensitivity in CC cells through the miR-21/PTEN axis.
circulation_biomarker_diagnosis_up	36344812	hsa-mir-27	Scleroderma, Systemic	MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease.
circulation_biomarker_diagnosis_up	36344812	hsa-mir-27a	Scleroderma, Systemic	MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease.
genetics_overexpression_promote	36343886	hsa-mir-421	Carcinoma, Renal Cell	Overexpression of miR-421 has reversed the anti-tumor function of circSCNN1A in RCC cells.
other	36343560	hsa-mir-148a	Drug Hypersensitivity	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Neurotic Disorders	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Fatigue	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Mood Disorders	RESULTS: A significantly negative correlation was observed between relative miR-148a expression in breast milk and the total mood disturbance T-score.
other	36343560	hsa-mir-148a	Substance Withdrawal Syndrome	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Pituitary Diseases	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
circulation_biomarker_diagnosis_ns	36343541	hsa-mir-513a	Pancreatic Carcinoma	Plasmids altering LINC01234, miR-513a-3p and H6PD expression were transfected into pancreatic cancer cells to assess the change in biological behaviors of pancreatic cancer cells.
lncRNA target	36343490	hsa-mir-10b	Inflammatory Bowel Diseases	Thus, miR-10b may be expected to be a new target for the treatment of IBD.
lncRNA target	36342850	hsa-mir-21	Triple Negative Breast Neoplasms	This compound was incorporated into the design of a next-generation RiboTAC that targeted the microRNA-21 (miR-21) precursor and alleviated a miRassociated cellular phenotype in triple-negative breast cancer cells.
other	36341564	hsa-mir-125b	Urinary Bladder Neoplasms	Furthermore, the modulation of miR-34a and miR-125b gene expression in association with increased MAGE-A6 and MAGE-A11 genes could open a new horizon in the improvement of bladder cancer.
transcription factor target	36341347	hsa-mir-93	Polycystic Ovary Syndrome	5p as a new molecular target for improving the function of GCs in PCOS patients.
lncRNA target	36341225	hsa-mir-17	Metabolic Diseases	TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR
lncRNA target	36341225	hsa-mir-17	Diabetes, Gestational	TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR
genetics_knock down_suppress	36340580	hsa-mir-640	Osteosarcoma	MCAM knockdown repressed OS cell growth and migration, while additional miR-640 depletion partially abolished the anticancer effects of MCAM knockdown in OS cells.
other	36340453	hsa-mir-135b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-98	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-191	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-146b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-150	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-29a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-134	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-148a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-23b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-34c	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-181d	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-133b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-155	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-17	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7d	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-29b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-125b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7f	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-16	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-92a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-15a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-372	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-142	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-143	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-138	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-181c	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
lncRNA target	36339585	hsa-mir-326	Osteoarthritis	Correspondingly, intracellular transfer of circPARD3B through OE-circPARD3B-SMSCs-sEV could postpone disease progression through a functional module regulated angiogenesis of circPARD3B-miRSIRT1, providing a novel therapeutic strategy for OA.
other	36338963	hsa-mir-141	Hemangioma, Infantile	5p) were significantly differentially expressed between IH and normal control (p < 0.05).
other	36338962	hsa-mir-147a	Ovarian Neoplasms	As a result, six genes (CDT1, CNIH4, CRLS1, LIMCH1, POC1A, and SNX13), and two miRNAs (mir-147a, and mir-103a-3p) were suggested as novel candidate prognostic biomarkers for ovarian cancer.
genetics_overexpression_suppress	36338839	hsa-mir-164	Dehydration	The heterologous accumulation of miR164g in Arabidopsis thaliana results in enhanced sensitivity to drought stress, while overexpression of MsNAC022 in Arabidopsis and the cultivated apple line 'GL-3' (Malus domestica Borkh.) lead to enhanced tolerance to drought stress by raising the ROS scavenging enzymes activity and related genes expression levels, particularly PEROXIDASE (MsPOD).
circulation_biomarker_diagnosis_up	36338741	hsa-mir-1228	Breast Neoplasms	Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes.
circulation_biomarker_diagnosis_up	36338741	hsa-mir-191	Breast Neoplasms	Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes.
other	36338672	hsa-mir-519b	Endometriosis	The present study aimed to investigate whether LncRNA HOTAIR regulates cell invasion and migration in endometriosis by regulating the miR-519b-3p/PRRG4 pathway.
lncRNA target	36338027	hsa-mir-29a	Laryngeal Neoplasms	In conclusion, hBMSC-derived Exo with upregulated miR-29a-3p inhibited laryngocarcinoma progression via regulating PTEN, providing a potential diagnostic and therapeutic target in this disease.
target gene	36337243	hsa-mir-195	Uterine Cervical Neoplasms	Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis.
other	36337027	hsa-mir-320c	Lung Neoplasms	Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.
other	36337027	hsa-mir-320d	Lung Neoplasms	Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.
other	36336926	hsa-mir-30	Atherosclerosis	CONCLUSION: These results suggested that circIRAK1 upregulated TRIM14 by interacting with miR5p, consequently contributing to ox-LDL-induced endothelial cell injury in AS.
exosome	36336217	hsa-mir-625	Colorectal Neoplasms	The current results indicated that CAFs-Exo was directly internalized by CRC cells, and exosomal miR
other	36336032	hsa-mir-101a	Reperfusion Injury	CONCLUSION: Altogether, RGD1564534 elevates the expression of Dusp1 by competitively binding to miR-101a-3p, which facilitates mitochondrial autophagy-mediated inactivation of NLRP3 inflammasome and thus retards cerebral I/R injury.
genetics_overexpression_promote	36336031	hsa-mir-140	Subarachnoid Hemorrhage	SAH rats were treated with the EVs sourced from microglia overexpressing miR
lncRNA target	36335997	hsa-mir-144	Schizophrenia	3p/ZBTB20/ERK/CREB1 signalling might be associated with schizophrenia-like abnormalities, suggesting potential therapeutic targets for future schizophrenia treatment.
genetics_knock down_suppress	36335987	hsa-mir-506	Ovarian Neoplasms	CONCLUSION: XIST knockdown inhibited autophagy and carboplatin resistance of OC through FOXP1/protein kinase B (AKT)/mammalian target of rapamycin pathway by targeting miR
transcription factor target	36335879	hsa-mir-614	Breast Neoplasms	5p suppressed the expression of TXNRD1 by directly binding to the 3'-untranslated region (UTR), and TXNRD1 inhibition significantly repressed the proliferation and metastasis capacity of BC cells upon Cd exposure.
lncRNA target	36335706	hsa-mir-21	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-150	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-375	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-103a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-155	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-140	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-20a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-130a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-125a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-101	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
other	36335210	hsa-mir-23b	Endometrial Neoplasms	Decreased miR-23b expression was associated with worse survival of EC patients.
other	36335210	hsa-mir-199a	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-221	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-146	Endometrial Neoplasms	Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2.
other	36335210	hsa-mir-34a	Endometrial Neoplasms	Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2.
other	36335210	hsa-mir-125b	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-451a	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36334906	hsa-mir-1	Wounds and Injuries	Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality.
other	36334906	hsa-mir-132	Wounds and Injuries	Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality.
other	36334875	hsa-let-7f-1	Intervertebral Disc Degeneration	3p/Bmal1/autophagy axis provides a potential therapeutic strategy for the clinical treatment of IDD.
circRNA target	36334805	hsa-mir-888	Triple Negative Breast Neoplasms	Furthermore, we found that inhibiting circRAD54L2 expression markedly reduced the invasion, metastasis, and proliferation of breast cancer cells via sponging of the miR-888 family, which downregulated the expression of pyruvate dehydrogenase kinase 1 (PDK1). CONCLUSION: Our results showed that circRAD54L2 could regulate PDK1 expression by sponging the miR-888 family competing for the ceRNA mechanism, indicating that circRAD54L2 may act as an essential upstream regulator and providing further mechanistic evidence to support the notion that circRAD54L2/miR-888s/PDK1 is a promising therapeutic target in the treatment of breast cancer.
genetics_knock down_promote	36334791	hsa-mir-19a	Neuralgia	To investigate into the role of miR-19a-3p and KLF7 in NP of rats, the knockdown of miR-19a-3p alone or along with KLF7 downregulation in rats were achieved through lentivirus injection.
other	36334781	hsa-mir-9	Stress Disorders, Post-Traumatic	Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group.
other	36334781	hsa-mir-34c	Stress Disorders, Post-Traumatic	Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group.
other	36334504	hsa-mir-106b	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-122	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-200c	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-423	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-1291	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-4433b	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
lncRNA target	36334219	hsa-mir-449a	Cardiomyopathies	Collectively, our study established CFAR as a new profibrotic factor acting through a novel miR-449a-5p/LOXL3/mTOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases.
circulation_biomarker_diagnosis_ns	36333771	hsa-mir-155	Acute Lung Injury	5p in the plasma.
circulation_biomarker_diagnosis_ns	36333771	hsa-mir-155	Pancreatitis	5p in the plasma.
other	36333728	hsa-mir-17	Diabetic Foot	3p had a negative regulatory effect on Flk-1.
transcription factor target	36333342	hsa-mir-584	Atherosclerosis	These results suggest that OASL1/OASL regulates endothelial biology by protecting NOS3 mRNA and targeting miR-584 represents a rational therapeutic strategy for eNOS maintenance in vascular disease.
genetics_GWAS	36333293	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA
genetics_GWAS	36333293	hsa-mir-9	Endometrial Neoplasms	These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA
genetics_overexpression_promote	36332797	hsa-mir-15a	Colorectal Neoplasms	Accordingly, overexpression of SIRT4 suppresses the miR-15a-5p-mediated enhancement in the proliferation, migration, and invasion of CRC cells, while the opposite phenotypes were observed after inhibition of SIRT4.
circulation_biomarker_diagnosis_up	36332335	hsa-mir-21	Colorectal Neoplasms	Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma.
circulation_biomarker_diagnosis_up	36332335	hsa-mir-221	Colorectal Neoplasms	Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma.
target gene	36331809	hsa-mir-18a	Urinary Bladder Neoplasms	LncRNA GAS5 regulates the Wnt/beta-catenin pathway through the miR-18a-5p/AXIN2/GSK3β axis to inhibit the proliferation and migration of bladder cancer cells.
genetics_knock down_promote	36331285	hsa-mir-152	Cholangiocarcinoma	PDK1 overexpression reversed the inhibition effect of miR
circRNA target	36330643	hsa-mir-424	Osteoarthritis	CONCLUSION: Hsa_circ_0004662 facilitates OA progression via the miR5p/VEGFA axis.
circulation_biomarker_prognosis_ns	36330573	hsa-mir-211	Vascular Calcification	The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR
circulation_biomarker_prognosis_ns	36330573	hsa-mir-211	Kidney Failure, Chronic	The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR
lncRNA target	36330459	hsa-mir-26a	Ischemic Stroke	CONCLUSIONS: TUG1/miR-26a, which may act as a regulatory axis in angiogenesis following ischemic stroke, can be considered a potential target for cerebral infarction therapy.
circulation_biomarker_diagnosis_up	36330052	hsa-mir-99a	Squamous Cell Carcinoma of Head and Neck	Furthermore, plasma EVs miR-99a-5p also distinguished early HNSCC with AUC of 0.7394 (95% CI: 0.6284-0.8504; p = 0.0002), with 79.07% sensitivity and 61.54% specificity, respectively.
circulation_biomarker_prognosis_up	36330017	hsa-mir-126	Infarct-Related Artery Total Occlusion	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-21	Infarct-Related Artery Total Occlusion	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-21	Myocardial Infarction, Acute	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-126	Myocardial Infarction, Acute	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
lncRNA target	36329790	hsa-mir-153	Prostatic Neoplasms	CONCLUSION: MiR-153 is up-regulated in PC tissues and may play an important role in aggressive PC by targeting potential target genes.
other	36329788	hsa-mir-129	Melanoma	lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma.
genetics_knock down_promote	36329586	hsa-mir-4324	Breast Neoplasms	CONCLUSIONS: High expression of Talin2 is associated with lymph node metastasis and HER-2 overexpression in breast cancer patients.Down-regulation of miR-4324 inhibits the proliferation, invasion and migration and induces apoptosis of breast cancer cells, and the inhibitory effect of miR-4324 knockdown on breast cancer cell migration is mediated probably by targeted inhibition of Talin2 expression.
transcription factor target	36329581	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells.
transcription factor target	36329581	hsa-mir-16	Breast Neoplasms	5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells.
genetics_knock down_promote	36329557	hsa-mir-637	Esophageal Squamous Cell Carcinoma	Loss of miR-637 promotes cancer cell stemness via WASH/IL-8 pathway and serves as a novel prognostic marker in esophageal squamous cell carcinoma.
other	36329419	hsa-mir-155	Multiple Sclerosis	CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required.
other	36329419	hsa-mir-145	Multiple Sclerosis	CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required.
other	36328940	hsa-mir-141	Anorectal Malformations	miR3p was downregulated in the ARM group, whereas Ubtd2 increased and colocalized with TUNEL-positive cells.
transcription factor target	36328305	hsa-mir-222	Spinal Cord Injuries	3p could alleviate the mitochondrial pathway-mediated apoptosis and motor dysfunction in rats after SCI by targeting Bbc3 and Bim.
lncRNA target	36328133	hsa-mir-374b	Neovascularization, Pathologic	Moreover, treatment of appropriate animal models either with a miR-374b-5p mimicry or with inhibitors of either stat3 acetylation, DNMT1, or EZH2, leads to marked inhibition of MCPpromoted neovascularization and tumor growth.
circulation_biomarker_diagnosis_ns	36328028	hsa-mir-1	Sarcopenia	CONCLUSIONS: These results suggest that circulating miR
circulation_biomarker_diagnosis_ns	36328028	hsa-mir-1	Heart Failure, Chronic	CONCLUSIONS: These results suggest that circulating miR
exosome	36327876	hsa-mir-29b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Extracellular vesicles derived from human bone marrow stem cells inhibit acute lymphoblastic leukemia cell growth by inhibiting MAPK pathway via the miR-29b-3p/GDF15 axis.
lncRNA target	36327779	hsa-mir-429	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-944	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-133b	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-451a	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
genetics_knock down_suppress	36327671	hsa-mir-145	Ovarian Neoplasms	5p reversed the effects of circ_0015756 knockdown on OC cells.
circulation_biomarker_diagnosis_ns	36327567	hsa-mir-106a	hereditary diffuse gastric cancer	The Cas13a-bHCR based SERS assay of gastric cancer-related miRNA-106a (miR-106a) can be achieved within 60 min and output significantly enhanced SERS signal due to the multiple signal amplification, which possesses a good linear calibration curve from 10 aM to 1 nM with the limit of detection (LOD) low to 8.55 aM for detecting gastric cancer-related miR-106a in human serum.
transcription factor target	36327448	hsa-mir-21	Breast Neoplasms	To overcome these limitations, synergistic combinatorial anti-tumor effect of Granzyme B (GrB) and miR-21 inhibitor (miR-21i) for breast cancer therapy through a new co-delivery system was investigated in present study. In conclusion, the nanocapsules for simultaneously delivery of GrB and miR-21i produce a synergistic effect in human breast cancer therapy.
other	36327243	hsa-mir-199a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
other	36327243	hsa-mir-26a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
other	36327243	hsa-mir-130a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
circulation_biomarker_diagnosis_ns	36327023	hsa-mir-367	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation.
circulation_biomarker_diagnosis_ns	36327023	hsa-mir-22	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation.
genetics_knock down_promote	36326978	hsa-mir-622	Glioma	miR-622 knockdown reversed the effect of Propofol on glioma progression.
target gene	36326553	hsa-mir-29a	Pneumonia	LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide.
target gene	36326553	hsa-mir-29a	Pulmonary Fibrosis	LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide.
transcription factor target	36326533	hsa-mir-133a	Hypercholesterolemia	In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats.
other	36326316	hsa-mir-590	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-15a	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-449a	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-381	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-454	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
lncRNA target	36326314	hsa-mir-8084	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-128	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-8084	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-494	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-494	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-128	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326096	hsa-mir-873	Esophageal Squamous Cell Carcinoma	In conclusion, UCA1 can protect Human Umbilical Vein Endothelial Cells from ox-LDL-induced injury via the miR5p/MAPK8 axis.
exosome	36325775	hsa-mir-204	Myocardial Reperfusion Injury	Results hUC-MSCs had adipogenic and osteogenic differentiation capabilities,and the exosomes were successfully identified.Compared with the negative control group,the miR-204 mimic group showed up-regulated expression of miR-204 in hUC-MSCs and their exosomes(P<0.001,P<0.001).Compared with the sham operation group,the modeling of I/R increased the left ventricular end-diastolic diameter(LVEDD)(P<0.001),left ventricular end-systolic diameter(LVESD)(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P<0.001),and CD11c(P<0.001).Meanwhile,it lowered the left ventricular ejection fraction(LVEF)(P<0.001),left ventricular fractional shortening(LVFS)(P<0.001),Arg-1(P<0.001),IL-10(P<0 CD206(P<0.001).Compared with those in the I/R group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P=0.010),and CD11c(P<0.001) reduced,while LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.028),and CD206(P=0.022) increased in the hUC-MSC exosomes group.Compared with those in the negative control group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P=0.001),and the levels of IL-1beta(P=0.048),TNF-alpha(P<0.001),and CD11c(P=0.007) reduced,while the LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.001),and CD206(P=0.001) increased in the miR-204 mimic group.
other	36325355	hsa-mir-181c	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-125b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-15b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-193b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
transcription factor target	36324898	hsa-mir-532	Colorectal Neoplasms	3p/si-KRAS might provide a promising potential strategy for inhibiting the malignant phenotypes of CRC cells.
transcription factor target	36324569	hsa-mir-140	Colorectal Neoplasms	Our results, both in vitro and in vivo, suggest that miR-140 may act as a tumor suppressor and plays an important role in DSB DNA repair and, consequently, CRC therapy response.
other	36324503	hsa-mir-23a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-29c	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-29b	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-200a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-145	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-22	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-20a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-34a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-27a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
transcription factor target	36324256	hsa-mir-101	Pre-Eclampsia	3p in placenta contributes to the development of PE by suppressing WDR5-mediated proliferation and invasion of trophoblast.
lncRNA target	36322830	hsa-mir-372	hereditary diffuse gastric cancer	Mining of this dataset across the human transcriptome defined a drug-like fragment that potently and specifically targeted the microRNA-372 hairpin precursor, inhibiting its processing into the mature, functional microRNA and alleviating invasive and proliferative oncogenic phenotypes in gastric cancer cells.
other	36322827	hsa-mir-148a	Leukemia, Myeloid	miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.
other	36322719	hsa-mir-29a	Neovascularization, Pathologic	Our data suggest that miR-29a may be a promising clinical candidate for the treatment of neovascular diseases.
other	36322706	hsa-mir-125a	Brain Ischemia	RESULTS: CircSTK39 and ERCC6 expression were significantly downregulated, but miR-125a-5p expression was upregulated in the lens tissues of ARC patients and H(2)O(2)-treated SRA01/04 cells.
genetics_knock down_promote	36322370	hsa-mir-340	Spinal Cord Injuries	Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis.
genetics_knock down_promote	36322370	hsa-mir-340	Subarachnoid Hemorrhage	Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis.
circulation_biomarker_diagnosis_down	36322282	hsa-mir-29a	Graves Disease	Collectively, our results demonstrate that miR-29a-3p emerges as a post-transcriptional brake to limit circulating Tfh memory cell response in GD patients and may be involved in the pathogenesis of GD.
other	36321868	hsa-mir-495	Squamous Cell Carcinoma of Head and Neck	Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC.
other	36321868	hsa-mir-495	Periodontitis	Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC.
other	36321836	hsa-mir-155	Esophageal Squamous Cell Carcinoma	MIR155HG encodes a precursor RNA of microRNA-155 (miRNA-155).
transcription factor target	36321792	hsa-mir-221	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Moreover, changes were observed in the expression of CDKN1B, a known target of miR
transcription factor target	36321792	hsa-mir-222	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Moreover, changes were observed in the expression of CDKN1B, a known target of miR
lncRNA target	36321407	hsa-mir-181c	Colorectal Neoplasms	To be concluded, SPR inactivates PI3K/AKT signaling pathway to suppress CRC cell proliferation, invasion, and migration via miR-181c/d-5p/RBM47.
exosome	36321189	hsa-mir-106	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-501	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-20a	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-20a	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-106	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-501	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
genetics_GWAS	36320325	hsa-mir-145	Urinary Bladder Neoplasms	MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa.
genetics_GWAS	36320325	hsa-mir-143	Urinary Bladder Neoplasms	MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa.
lncRNA target	36320323	hsa-mir-196a	Huntington Disease	Taken together, miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in HD, supporting the neuroprotective functions of miR-196a through neuronal cytoskeleton in HD.
exosome	36319884	hsa-mir-222	AIDS-Related Complex	Exosomal miR
other	36319782	hsa-mir-10	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
other	36319782	hsa-mir-21	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
other	36319782	hsa-mir-124	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
exosome	36319622	hsa-mir-181d	Carcinoma, Renal Cell	Further investigation revealed that CAFs could enhance cancer stemness through delivering exosomes to RCC cells, and miR-181d-5p was identified as the critical exosomal miRNA in CAF-secreted exosomes by small RNA sequencing and subsequent screening assays. Mechanistically, exosomal miR-181d-5p transferred from CAFs to RCC cells directly suppressed the expression of ring finger protein 43 (RNF43) and activated Wnt/beta-catenin signaling pathway, thus promoted cancer stemness and tumor progression.
other	36319098	hsa-mir-196b	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-874	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-296	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-503	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-150	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-100	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-940	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-543	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-628	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-299	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
lncRNA target	36319097	hsa-mir-155	Pulmonary Disease, Chronic Obstructive	These results suggest that miR-155 activates the PTEN/PI3K/Akt signaling pathway by targeting PIK3R1 to promote the occurrence and development of COPD, which provides new evidence for the use of miR-155 in the treatment of COPD.
other	36319063	hsa-mir-125b	Colonic Neoplasms	Furthermore, in human colon adenocarcinoma patients, we verified that miR-125b-5p expression was downregulated, and low levels of miR-125b-5p were associated with poor prognosis.
other	36318963	hsa-mir-29a	Alzheimer Disease	In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD.
other	36318963	hsa-mir-29	Alzheimer Disease	In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD.
other	36317581	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects.
other	36317581	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects.
genetics_knock down_promote	36317454	hsa-mir-138	Colorectal Neoplasms	5p was downregulated in CRC and its knockdown accelerated CRC progression.
target gene	36317339	hsa-mir-181a	Stomach Neoplasms	TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
genetics_GWAS	36317205	hsa-mir-146	Primary Ovarian Insufficiency	RESULTS: Compared with control group, the expression level of miRNA-146 in POI group was significantly lower, the expression level of OX-LDL and ROS were significantly higher, and the ovarian volume and peak systolic blood flow velocity of ovarian artery were significantly decreased in POI group.
other	36316703	hsa-mir-29b	Colorectal Neoplasms	Functional assays revealed that LIFR-AS1 could competitively bind to hsa-miR-29b-3p, and repressed colon cancer cell proliferation, colony formation and invasion.
circRNA target	36316592	hsa-mir-185	Diabetic Nephropathies	Circ_0008529 might be a potential target for DN, which regulated DN progression via miR5p/SMAD2 pathway.
lncRNA target	36316351	hsa-mir-34c	Stomach Neoplasms	Accordingly, our results support that E2F1 is an engaging target of drug development in tumor growth and aggressive proliferation of GC, and favorable results can be achieved through tumor suppressor lncRNA GAS5/miR-34c axis in GC.
other	36316110	hsa-mir-23b	Stomach Neoplasms	Moreover, low miR-23b expression predicted longer 10-year survival (P=0.0066) in patients with GC. MiR-23b-5p expression status could serve as a prognostic marker for survival in patients with GC.
circRNA target	36315981	hsa-mir-587	Uterine Cervical Neoplasms	CONCLUSION: Circ_0031027 inhibited the enlargement of CC by miR-587/SOCS5.
lncRNA target	36315357	hsa-mir-29b	Cardiomyopathies	Overall, our findings imply that induction of miR-29b-3p, which negatively regulates GSK-3beta and BMF expression, attenuates CME-induced myocardial injury, suggesting a novel potential therapeutic target for cardioprotective after CME.
circRNA target	36315192	hsa-mir-190a	Reperfusion Injury, Renal Ischemia	Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway. Taken together, our data showed that circRNA_45478/miR-190a-5p/PHLPP1 axis mediated the progression of ischemic AKI.
genetics_overexpression_promote	36314369	hsa-mir-92a	Uterine Cervical Neoplasms	Functional rescue assays revealed that miR-92a-3p overexpression or BTG2 downregulation reversed the inhibitory role of CARMN overexpression in CC cell growth.
circRNA target	36314002	hsa-mir-370	FG syndrome	CONCLUSION: The hsa-circ-0005238 modulates FGR pathogenesis by inhibiting trophoblast cell invasion and migration through sponging hsa-miR3p.
lncRNA target	36313765	hsa-mir-34a	Uterine Cervical Neoplasms	A pair of ceRNAs (CA9/ULBP2) could be involved in the carcinogenesis and development of cervical cancer, and the potential target might be hsa-miR-34a. Further research found that the ceRNA pairs of ULBP2/CA9 could regulate cervical cancer through hsa-miR-34a.
circRNA target	36313671	hsa-mir-361	Colonic Neoplasms	CircHADHA increased the expression of ATG13 via miR-361 in both colon epithelial and cancer cells. CircHADHA promoted autophagy by regulating ATG13 via miR-361 in both colon epithelial and cancer cells.
genetics_knock down_suppress	36313631	hsa-let-7g	Gallbladder Neoplasms	The loss of let-7g-5p enhanced the expression of IGF2BP3 and improved GBC progression.
target gene	36313626	hsa-mir-1	Breast Neoplasms	The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31.
other	36313468	hsa-mir-103a	Colorectal Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-193b	Colorectal Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-103a	Colonic Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-193b	Colonic Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
circulation_biomarker_diagnosis_up	36313425	hsa-mir-486	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-let-7e	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-223	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-152	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-199a	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-148a	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
other	36313069	hsa-mir-642a	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36313069	hsa-mir-652	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36313069	hsa-mir-630	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36312756	hsa-mir-129-2	Breast Neoplasms	Furthermore, the expression of miR2-3p in breast cancer patients was about twice that in healthy people.
lncRNA target	36312597	hsa-mir-22a	Hypertension, Pulmonary	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-22a	Hypertension, Portal	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-34a	Hypertension, Portal	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-34a	Hypertension, Pulmonary	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
other	36312586	hsa-mir-92b	Breast Neoplasms	Moreover, we identified the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer. We discovered the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer, which has not yet been investigated previously.
other	36312469	hsa-mir-139	Carcinoma, Hepatocellular	The SNHG3/THUMP3-AS1-miR5p-SMARCA4 ceRNA network was established and could be assumed to serve as a stimulatory mechanism in HCC.
genetics_knock down_promote	36311891	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	5p knockdown exerted the opposite effects.
exosome	36311808	hsa-mir-466	Heat Stroke	CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke.
exosome	36311808	hsa-mir-466	Brain Injuries	CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke.
other	36311688	hsa-mir-20b	Prostatic Neoplasms	miR-20b-5p is a novel biomarker for detecting prostate cancer.
lncRNA target	36311369	hsa-mir-21	Carcinoma, Renal Cell	Eventually, two novel lncRNAs, AL162377.1 and AF111167.2, targeting the miR
other	36311195	hsa-mir-574	Esophageal Squamous Cell Carcinoma	MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
other	36311189	hsa-mir-146a	Drug Hypersensitivity	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-106a	Drug Hypersensitivity	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-106a	Inflammation	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-146a	Inflammation	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311149	hsa-mir-10a	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10a	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10a	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
target gene	36311048	hsa-mir-210	Inflammatory Osteolysis	Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat in fl ammatory or infective osteolysis and identifies a novel role of miR3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression.
other	36310619	hsa-mir-342	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
other	36310619	hsa-mir-142	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
other	36310619	hsa-mir-199a	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
circulation_biomarker_diagnosis_down	36310502	hsa-mir-196a	Squamous Cell Carcinoma of Head and Neck	Additionally, in both DDP-resistant and -sensitive lines, GAS5 showed a cytoplasmic distribution and downregulated miR-196a in OSCC tissues.
other	36310379	hsa-mir-222	Diabetes Mellitus	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes.
other	36310379	hsa-mir-222	Insulin Resistance	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes.
other	36310379	hsa-mir-222	Metabolic Diseases	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. Altogether, miR-222 exerts a direct effect in metabolic pathways of 3T3-L1 adipocytes that are relevant to adipocyte function, limiting adipogenesis and insulin signaling pathways, offering a mechanistic explanation for its reported association with metabolic diseases.
genetics_overexpression_promote	36309967	hsa-mir-548k	Breast Neoplasms	In this study, the significant overexpression of miR-548k in breast cancer tissues compared to adjacent normal tissues was confirmed.
other	36309937	hsa-mir-29c	Neurodegenerative Diseases	Recent reports have suggested that abnormal miR-29c expression in hippocampus have been implicated in the pathophysiology of some neurodegenerative and neuropsychiatric diseases.
other	36309937	hsa-mir-29c	Brain Diseases	Therefore, miR-29c might be a potential therapeutic agent for TNF-alpha accumulation and toxicity-related brain diseases.
exosome	36309693	hsa-mir-655	Osteosarcoma	LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal.
genetics_knock down_promote	36309620	hsa-mir-378a	Carcinoma, Renal Cell	The results of loss-of-function experiments showed that inhibition of TOB2 reversed the inhibitory roles of miR-378a-3p inhibitor on RCC progression.
transcription factor target	36309619	hsa-mir-27a	Lung Neoplasms	METHODS: We detect the expression of miR-27a after exposure to hypoxia conditions in lung cancer cells via qPCR.
target gene	36309571	hsa-mir-29a	Rhabdomyosarcoma	A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a.
circulation_biomarker_diagnosis_up	36308704	hsa-mir-182	Parkinson Disease	5p delivered by plasma exosomes promotes sevoflurane-induced neuroinflammation and cognitive dysfunction in aged POCD rats by targeting BDNF and activating the NF-kappaB pathway.
transcription factor target	36308623	hsa-mir-106b	Intervertebral Disc Degeneration	Our findings demonstrate that targeting miR-106b-5p in intervertebral disc has therapeutic effects on IDD.
other	36308360	hsa-mir-182	Breast Neoplasms	COCLUSION: Down regulation of FOXO3 and up regulation of miR-182 expression was associated with advanced breast cancer.
circulation_biomarker_diagnosis_ns	36307990	hsa-mir-542	Lupus Erythematosus, Systemic	5p expression positively correlated with the levels of polyamine synthetases in peripheral blood mononuclear cells of patients with SLE as well as disease severity.
virus_miRNA	36307872	ebv-mir-BART18	Colorectal Neoplasms	BART18-3p Promotes Colorectal Cancer Progression by Targeting De Novo Lipogenesis
circulation_biomarker_diagnosis_up	36307470	hsa-mir-543	Osteoarthritis	Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA.
circulation_biomarker_diagnosis_up	36307470	hsa-mir-542	Osteoarthritis	Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA.
other	36307001	hsa-mir-195	Carcinoma, Hepatocellular	Several studies found that miR-195 plays an unavoidable role in the regulation of cell proliferation, cycle and apoptosis in hepatocellular carcinoma (HCC).
circulation_biomarker_diagnosis_ns	36306116	hsa-mir-124	Parkinson Disease	MATERIAL AND METHODS: The circHIPK3 and microRNA-124 (miR-124) expression in human serum and cerebral fluid was detected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 92 PD patients and 95 controls.
genetics_knock down_suppress	36306049	hsa-mir-205	Norrie disease	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
genetics_knock down_suppress	36306049	hsa-mir-205	Fibrosis	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
genetics_knock down_suppress	36306049	hsa-mir-205	Inflammation	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
other	36306007	hsa-mir-27b	Thyroid Neoplasms	LINC01089 blocks malignant progression of thyroid cancer by binding miR-27b-3p to enhance the FBLN5 protein level.
genetics_knock down_suppress	36305971	hsa-mir-135b	Protein-Losing Enteropathies	Knockdown of BMPER or overexpression of miR-135b inhibited the osteogenic differentiation of CTS-induced ossification in PLL cells.
genetics_overexpression_suppress	36305754	hsa-mir-133a-2	Uterine Cervical Neoplasms	The overexpression of hsa-mir-133a-2 significantly inhibits the proliferation and invasion of cervical cancer cells.
genetics_GWAS	36305672	hsa-mir-196a-2	Carcinoma, Non-Small-Cell Lung	This nanodevice can detect miR-196a2T with an ultralow detection limit of 2.46 aM; distinguish rare miR-196a2 SNP with a selectivity factor of 0.001%; and even profile miR-196a2T in human tissues for nonsmall cell lung cancer (NSCLC) diagnosis, risk assessment, and cancer type prediction.
transcription factor target	36305548	hsa-mir-140	Breast Neoplasms	3p regulates the expression of USP36, which mediates ubiquitination and regulates the expression of PKM2, and regulates the malignant biological behavior of breast cancer through the energy metabolism process.
other	36305435	hsa-mir-206	Rhinitis, Allergic, Seasonal	miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR.
other	36305435	hsa-mir-126	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-206	Asthma	miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR.
other	36305435	hsa-mir-125b	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-125b	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-126	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-133b	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-181a	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-133b	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-181a	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
genetics_knock down_suppress	36305147	hsa-mir-424	Breast Neoplasms	5p; LINC00473 knockdown impeded the growth, migration, invasion, and epithelial-mesenchymal transition of BC cells, while these effects were abolished by miR
other	36305048	hsa-mir-873	Stomach Neoplasms	CONCLUSION: Our research showed that hsa_circ_0005529 promoted tumorigenic behavior in gastric cancer cells by adsorbing miR5p to modulate ZEB1 levels.
lncRNA target	36304947	hsa-mir-27a	Tuberculosis	RESULTS: Differential miRNA expression profiles were obtained, and miR-27a-3p and miR-30b-5p were highly expressed in patients with TB. CONCLUSION: Our study not only identified differentially expressed miRNAs between the TB and control groups but also revealed that miR-27a-3p and miR-30b-5p regulate proinflammatory cytokine secretion and macrophage differentiation through VDR in macrophages.
lncRNA target	36304901	hsa-mir-185	Short Stature, Idiopathic, Autosomal	Finally, the authors revealed that the silencing of hsa_circ_0008870 induces low expression of MAPK1 by impairing the sponge action of miR3p, thereby inhibiting chondrocyte proliferation, hypertrophy, and endochondral ossification, which results in a short stature phenotype.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-106a	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-194	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-17	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-17	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-194	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-106a	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
other	36304467	hsa-mir-196a-1	Intestinal Diseases	3p, respectively, to play a regulatory role in the process of high-altitude hypoxia-induced intestinal injury.
genetics_knock down_suppress	36304135	hsa-mir-512	Adenocarcinoma of Lung	Overexpression of HMGA1 could restore the inhibitory effects of miR
other	36303988	hsa-mir-34a	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-122	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-1260a	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-93	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
lncRNA target	36303447	hsa-mir-433	Glioma	3p suppressed glioma malignant progression via inhibiting NR5A2.
lncRNA target	36303271	hsa-mir-21	Nasopharyngitis	Collectively, EGF upregulates HIF-1alpha and miR-21 expression to inhibit AQP4 expression, thereby promoting the proliferation of nasal epithelial cells and the development of CRS.
transcription factor target	36303071	hsa-mir-29b	Huntington Disease	We observed age-associated alterations in chromatin accessibility between HD-MSNs and pre-HD-MSNs and identified miR-29b-3p, whose age-associated upregulation promotes HD-MSN degeneration by impairing autophagic function through human-specific targeting of the STAT3 3' untranslated region. Reducing miR-29b-3p or chemically promoting autophagy increased the resilience of HD-MSNs against neurodegeneration.
genetics_GWAS	36303006	hsa-mir-146a	Arthritis, Rheumatoid	The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied.
genetics_GWAS	36303006	hsa-mir-499	Arthritis, Rheumatoid	The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied.
genetics_overexpression_promote	36302829	hsa-mir-181b	Cardiomyopathies, Uremic	In addition, miR-181b-5p overexpression exhibited same effects with ANRIL silencing in UC.
exosome	36302748	hsa-mir-592	Melanoma	Thus, via the extracellular vesicle miR-592/PTPN7/MAPK axis, melanoma-CSCs can transfer their metastatic ability to the low-metastatic non-CSC melanoma cells.
transcription factor target	36302626	hsa-mir-23b	Vascular Diseases	These findings suggest that correcting the dysregulation of miR-23b/SMAD3 or lactate metabolism is a potential treatment for vascular diseases.
lncRNA target	36302471	hsa-mir-214	Pneumococcal Infections	5p and C1QTNF1 as potential novel targets for the treatment of PCV2 infection.
transcription factor target	36302396	hsa-mir-29a	Abortion, Habitual	Conclusion: MiR-29a may be involved in the pathogenesis of RSA by inhibiting the protein expressions of FKBP52 and VEGF, promoting the apoptosis of trophoblasts, and impairing neovascularization, resulting in placental vascular dysplasia..
lncRNA target	36301978	hsa-mir-217	Urinary Bladder Neoplasms	The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR
lncRNA target	36301978	hsa-mir-103a	Urinary Bladder Neoplasms	The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR
transcription factor target	36301034	hsa-mir-762	Lupus Vasculitis, Central Nervous System	CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE.
transcription factor target	36301034	hsa-mir-762	Lupus Erythematosus, Systemic	CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE.
lncRNA target	36301033	hsa-mir-582	Ataxia Neuropathy Spectrum	The potential diagnostic and therapeutic strategies targeting miR
other	36301024	hsa-mir-506	Obesity	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-124	Colorectal Neoplasms	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-124	Obesity	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-506	Colorectal Neoplasms	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
circulation_biomarker_diagnosis_up	36300679	hsa-mir-146a	Peripartum Cardiomyopathy 	The myocardial up-regulation of the PPCM biomarkers plasminogen inhibitor activator 1 (PAI-1) and miR-146a were prevented by both cabergoline and bromocriptine therapy.
target gene	36300495	hsa-mir-541	Uterine Cervical Neoplasms	Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling.
exosome	36299891	hsa-mir-222	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-146a	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-221	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-124	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-181a	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-126	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-93	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-21	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-181b	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-143	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-210	Cardiomegaly	5p) or in EV-BMMSCs (miR
genetics_overexpression_promote	36299824	hsa-mir-452	Breast Neoplasms	Additionally, RGS2 overexpression inhibited the malignant phenotypes of BC cells, but miR
target gene	36299503	hsa-mir-6867	Gallbladder Neoplasms	HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells.
genetics_overexpression_promote	36299488	hsa-mir-512	Pre-Eclampsia	3p-overexpressing trophoblast and PE-associated placentas.
circulation_biomarker_diagnosis_ns	36299385	hsa-mir-21	Glioblastoma	Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma.
circulation_biomarker_diagnosis_ns	36299385	hsa-mir-326	Glioblastoma	Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma.
lncRNA target	36299340	hsa-mir-28	Chronic Periodontitis	5p may participate in CP progression by targeting SPHK1 to regulate the proliferation and inflammation of PDLCs.
genetics_knock down_suppress	36299308	hsa-mir-940	Periodontitis	RESULTS: Higher abundance of circ_0099630 and TRAF6 and lower miR-940 expression were observed in periodontitis, and circ_0099630 knockdown attenuated the damage of human PDL cells (PDLCs) induced by lipopolysaccharides (LPS). CONCLUSION: Silencing circ_0099630 alleviates LPS-induced periodontal ligament cell injury via targeting miR-940/TRAF6/NF-kappaB in periodontitis.
genetics_overexpression_suppress	36298739	hsa-mir-155	Nervous Necrosis Virus Infectious	Subsequently, it was proved that overexpression of cal-miR-155 enhanced cell apoptosis with or without NNV infection and inhibited virus replication in CAB cells.
target gene	36297369	hsa-mir-34a	Liver Neoplasms	Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells.
circulation_biomarker_diagnosis_ns	36297290	hsa-mir-126	Diabetes Mellitus, Type 2	Our results revealed that HFD/STZ-induced T2D increased fasting blood glucose, ET-1, ICAM-1, E-selectin, and VIP levels, while decreasing the expression of both microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR phosphorylation.
transcription factor target	36296612	hsa-mir-145	Pituitary Diseases	The study aimed to investigate whether the protective effects of LSW against endothelial dysfunction on vascular endothelial cells (VECs) was via vascular smooth muscle cells (VSMCs)-derived miRNA-145 packaged in EVs.
other	36295655	hsa-let-7e	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
other	36295655	hsa-mir-375	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
other	36295655	hsa-mir-210	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
exosome	36295638	hsa-mir-10b	Squamous Cell Carcinoma of Head and Neck	Conclusions: Salivary exosomal miR-10b-5p and miR
exosome	36295638	hsa-mir-486	Squamous Cell Carcinoma of Head and Neck	Conclusions: Salivary exosomal miR-10b-5p and miR
other	36295630	hsa-mir-609	Hemoglobin SC Disease	miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF.
other	36295630	hsa-mir-483	Hemoglobin SC Disease	miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF.
genetics_knock down_promote	36295086	hsa-mir-371a	Carcinoma, Hepatocellular	Moreover, gain- and loss-of-function assays and rescue assays were used to evaluate the mediated effect of BECN1-dependent autophagy on the role of miR-371a-5p in the response of HCC cells to OXA.
other	36295073	hsa-let-7	Colorectal Neoplasms	Our results sustain the relationship between the IGF axis, let-7 miRNAs, and CRC and suggest an association between the expression of these miRNAs and perineural invasion.
other	36293469	hsa-mir-145	Retinoblastoma	Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients.
other	36293268	hsa-mir-499	Severe Acute Respiratory Syndrome	These results indicate that IH stress downregulates the miR-499 in cardiomyocytes, resulting in increased levels of Reg IV and Hgf mRNAs, leading to the protection of cardiomyocytes in SAS patients.
other	36293237	hsa-mir-34b	Infertility, Male	miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia.
other	36293237	hsa-mir-34c	Infertility, Male	miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia.
other	36293154	hsa-mir-182	Choriocarcinoma	Transfecting a synthetic miR5p mimic decreased spheroid attachment of human JAr choriocarcinoma cells and E-cadherin expression (which is important for endometrial receptivity).
lncRNA target	36293154	hsa-mir-182	Embryo Loss	The miR5p/NDRG1 Axis Controls Endometrial Receptivity through the Endometrial receptivity is essential for successful pregnancy, and its impairment is a major cause of embryo-implantation failure.
other	36293110	hsa-mir-20a	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36293110	hsa-mir-101	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36293110	hsa-mir-21	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36292960	hsa-mir-126	Diabetic Nephropathies	We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition.
other	36292960	hsa-mir-145	Diabetic Nephropathies	We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition.
genetics_GWAS	36292185	hsa-mir-34b	Thyroid Neoplasms	To date, no study has been performed to evaluate the alterations of miRNA-146ars2910164 and miRNA34b/crs4938723 polymorphism as a risk factor in the development of thyroid cancer in the Pakistani population. Similarly in miRNA-34b/c gene SNP rs4938723 was observed to have a strong association with the development of thyroid cancer as the frequency of rare allele C was higher in patients.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-92a	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-20a	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-145	Diabetic Retinopathy	5p, and miR-145 in the serum and none in the vitreous samples.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-486	Diabetic Retinopathy	5p, and miR-145 in the serum and none in the vitreous samples.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-375	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-223	Diabetic Retinopathy	3p in the serum, with miR
transcription factor target	36291907	hsa-mir-181a	Retinoblastoma	We thus identified miR-181a-5p as a therapeutically exploitable target for EMT-triggered drug-resistant cancers that halted their invasion and migration and sensitized them to low-dose chemotherapy drugs.
lncRNA target	36291876	hsa-mir-214	Melanoma	This finding points to miR-214 as a potential new therapeutic target to prevent melanoma intravasation.
other	36291859	hsa-mir-338	Adenocarcinoma of Lung	3p (upregulation)-MCM4 (downregulation) pattern significantly improved the overall survival of LUAD patients (p = 0.0093).
genetics_GWAS	36291816	hsa-mir-142	Lymphoma, Large B-Cell, Diffuse	RESULTS: By proteome analyses, miR-142 knockout resulted in a consistent up-regulation of 52 but also down-regulation of 41 proteins in GC-DLBCL lines BJAB and SUDHL4.
other	36291575	hsa-mir-31	Prostatic Neoplasms	RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group.
other	36291575	hsa-mir-200b	Prostatic Neoplasms	RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group.
transcription factor target	36291177	hsa-mir-147	Arthrogryposis and ectodermal dysplasia	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
transcription factor target	36291177	hsa-mir-147	Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, X-Linked	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
transcription factor target	36291177	hsa-mir-147	Darier Disease	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
other	36291136	hsa-mir-155	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-155	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-20a	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-128	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-16	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-128	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-16	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-20a	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-133a-1	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-425	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-429	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-30	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-620	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-1	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-93	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-210	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-339	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-1208	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
other	36290936	hsa-mir-21	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-21	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-21	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290678	hsa-mir-4732	Cardiotoxicity	Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage.
other	36290678	hsa-mir-4732	Breast Neoplasms	Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage.
lncRNA target	36290402	hsa-mir-381	Endomyocardial Fibrosis	3p suppressed IMF deposition by inhibiting preadipocyte cell differentiation and lipid droplet deposition via the suppression of FABP3 expression in the peroxisome proliferator-activated receptor signalling pathway, whereas lncRNA4789 rescued FABP3 expression by sponging miR
target gene	36290289	hsa-mir-1275	Carcinoma, Hepatocellular	Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway.
other	36289853	hsa-mir-16	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-24	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-24	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-133a	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-210	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-16	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-21	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-21	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-155	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-155	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-210	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-133a	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289702	hsa-mir-124	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-27b	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-124	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-26a	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-27b	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-126	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-26a	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-126	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-181a	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-181a	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
lncRNA target	36289686	hsa-let-7c	Carcinoma, Renal Cell	Transfection of ccRCC cells with pre-let-7c-5p significantly inhibited proliferation, migration, invasion, and IGF1R expression.
genetics_GWAS	36289656	hsa-mir-181a	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-10a	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-499	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-499b	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
other	36289615	hsa-mir-184	Keratoconus	miRNA analysis detected 16 altered species, including miR-184, responsible for familial severe keratoconus.
lncRNA target	36289596	hsa-mir-182	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-23a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-20b	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-218	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-34a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-99a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
transcription factor target	36289489	hsa-mir-196b	Acute Lung Injury	CONCLUSIONS: Combination therapy with BUD and NAC ameliorates LPS-induced ALI by attenuating neutrophil recruitment through the miR-196b-5p/Socs3 molecular axis.
tissue_expression_ns	36289359	hsa-mir-4653	Carcinoma, Pancreatic Ductal	3p, decreased in the order-normal pancreatic duct, low-grade PanIN, high-grade PanIN, and PDAC.
other	36289253	hsa-mir-25	Brain Injuries	5p is a candidate treatment for septic encephalopathy.
other	36289253	hsa-mir-25	Sepsis-Associated Encephalopathy	5p is a candidate treatment for septic encephalopathy.
lncRNA target	36289101	hsa-mir-125a	Hepatitis B, Chronic	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289101	hsa-mir-125a	Hepatitis	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289101	hsa-mir-125a	Diabetic Nephropathies	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289041	hsa-mir-193a	Breast Neoplasms	The miR-193a-5p upregulation restrained chemoresistance and BC progression by the downregulation of Rap2A. CONCLUSION: All results unraveled that circ_0001667 contributed to ADM resistance and tumor development in BC via the miR-193a-5p-mediated Rap2A expression change, providing a novel regulatory mechanism for circ_0001667.
lncRNA target	36288952	hsa-mir-532	Colorectal Neoplasms	3p may serve as a potential target for treating colorectal carcinoma.
lncRNA target	36288764	hsa-mir-27a	Infertility, Female	CONCLUSION: These findings indicate a pro-survival mechanism of the MyoD/miR-27a-3p/Vangl1/Vangl2 axis for granulosa cell proliferation and suggest a novel target for the improvement of female fertility.
transcription factor target	36288761	hsa-mir-142	Uterine Cervical Neoplasms	5p acts as a tumor suppressor in cervical cancer.
lncRNA target	36288387	hsa-mir-3165	Urinary Bladder Neoplasms	Additionally, miR-3165 inhibits METTL14 expression to promote BCa progression. In addition, miR-3165 down-regulates METTL14 expression to promote BCa progression.
lncRNA target	36287177	hsa-mir-141	Colonic Neoplasms	Collectively, our findings suggest an important role of the Sohlh2/LncRNA-H19/miR-141/beta-catenin pathway in regulating colon CSC stemness and differentiation, suggesting potential therapeutic targets for colon cancer.
exosome	36287066	hsa-mir-216a	Colitis	CONCLUSIONS: Exosomal miR-216a-5p released from hypoxia-prime ASCs showed higher therapeutic efficiency than NExos in experimental colitis by promoting the M2 macrophage phenotype, which indicated that hypoxia prime may represent a promising approach to optimizing the function of ASC-derived exosomes.
genetics_knock down_promote	36286392	hsa-mir-562	Wilms Tumor	CONCLUSION: Knockdown of hsa_circ_0093741 suppresses nephroblastoma cell growth, migration and invasion by regulating the miR-562/FRS2 axis, suggesting the potential involvement of hsa_circ_0093741 in nephroblastoma progression.
other	36286245	hsa-mir-198	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-138	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-155	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-29c	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-223	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-146a	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286075	hsa-mir-885	Mast Cell Tumors	This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR).
genetics_GWAS	36286075	hsa-mir-21	Mast Cell Tumors	Overall, salivary miR-21 was identified as a promising tool, representing a novel approach to detecting MCT-associated epigenetic alterations in a minimally invasive manner.
other	36286075	hsa-mir-379	Mast Cell Tumors	This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR).
circulation_biomarker_diagnosis_up	36286043	hsa-mir-122	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-33a	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-21	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-33a	Atherosclerosis	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-122	Atherosclerosis	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-21	Atherosclerosis	5p in serum and the liver.
other	36286041	hsa-mir-146a	Melanoma	Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation.
circulation_biomarker_diagnosis_ns	36286037	hsa-mir-200b	Carcinoma, Hepatocellular	Expression of the five most common HCC-involved miRNAs (miR-122, miR-200a, miR-200b, miR-221, miR-222) was examined in serum using quantitative real time PCR (qRT-PCR).
exosome	36285300	hsa-mir-21	Pancreatic Neoplasms	Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression.
genetics_knock down_suppress	36285295	hsa-mir-214	Fibrosis, Renal	3p knockdown can reduce renal interstitial fibrosis through the PTEN/PI3K/AKT pathway.
lncRNA target	36284668	hsa-mir-598	Retinoblastoma	3p inhibitor.
genetics_overexpression_promote	36284637	hsa-mir-3960	Pancreatic Carcinoma	Overexpression of miR-3960 antagonized the promotion effect of exosomes on PC cells and the TFAP2A/PTEN/AKT signaling pathway, inhibiting the growth of tumors.
other	36284632	hsa-mir-375	Carcinoma, Hepatocellular	miR-375 was obviously augmented in Exo(IL2-TAM) and HCC cells treated with Exo(IL2-TAM).
circulation_biomarker_diagnosis_down	36284455	hsa-mir-155	Herpesviridae Infections	In this study, we discovered that the expression of GATA-binding protein 3 (GATA3) was lowly expressed in KS tissues and KSHV-infected cells, while microRNA-155 (miR-155) was highly expressed in KS serum and KSHV-infected cells.
circulation_biomarker_diagnosis_up	36284396	hsa-mir-210	Ischemic Stroke	RESULTS: MiR-210 was significantly upregulated in exosomes of the MCAO plasma, and further enhanced by EA therapy.
transcription factor target	36284391	hsa-mir-9	Nervous System Diseases	MiR-9 may be a potential target of nervous system diseases.
genetics_GWAS	36284378	hsa-mir-5189	Arthritis, Rheumatoid	OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients.
genetics_GWAS	36284378	hsa-mir-595	Arthritis, Rheumatoid	OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients.
other	36284205	hsa-mir-20	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-126	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-21	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-21	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-20	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-126	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
lncRNA target	36283303	hsa-mir-159	Sepsis	Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response.
lncRNA target	36283303	hsa-mir-160	Sepsis	Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response.
other	36282999	hsa-mir-21	Diabetes Mellitus	Differences in the expression patterns of miR-21 during diabetic wound healing identifies the potentially critical role of therapeutic timing, for miR-21 based therapies, in driving positive outcomes for patients.
other	36281935	hsa-mir-608	Endometriosis	Based on our previous results, the aim of the present study was to explore the role of lncRNA long intergenic nonprotein coding RNA (LINC)01960201 in in vitro decidualization of endometrial stromal cells in endometriosis during the window of implantation, as well as to explore the biological function of LINC01960201, and the regulation of a disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7), hsamicroRNA (miR)760 and hsamiR608 in the decidualization of endometrial stromal cells with endometriosis.
exosome	36281649	hsa-mir-200b	Breast Neoplasms	Collectively, TXT-resistant TNBC cell-derived exosomal LINC00667 could decrease the chemosensitivity of TNBC cells to TXT via regulating miR-200b-3p/Bcl-2 axis.
genetics_overexpression_promote	36281584	hsa-mir-29a	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-205	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-93	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-29	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
lncRNA target	36281526	hsa-mir-101	Stomach Neoplasms	The lncRNA SNHG22 promotes the proliferation, migration, and invasion of GC cells via the miR
transcription factor target	36281492	hsa-mir-9a	Inflammatory Bowel Diseases	This study finds that miRNA-9a-5p targets NOX4 to suppress ROS production, which plays an important role in mucosal barrier damage in IBD.
genetics_knock down_promote	36281372	hsa-mir-23b	Carcinoma, Hepatocellular	In addition, transforming growth factor beta1 (TGF-beta1) stimulation after miR-23b-3p overexpression induced neither the mesenchymal phenotype nor migratory property of HCC cells.
other	36280145	hsa-mir-143	Premature Birth	Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth.
other	36280145	hsa-mir-199b	Premature Birth	Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth.
transcription factor target	36279730	hsa-mir-2115	Pre-Eclampsia	3p might interact with the GOT1 mRNA to downregulate its expression, further inhibiting the hypoxia-promoted ferroptosis in a PE model.
lncRNA target	36279670	hsa-mir-145	Arthritis, Rheumatoid	5p/FZD4 signal axis plays an important role in promoting the pathogenesis of RA, and CAR from CCO may inhibit RA pathology by combining the FZD4 and further blocking this signal axis.
circulation_biomarker_diagnosis_ns	36279183	hsa-mir-222	Prostatic Neoplasms	The diagnostic value of the plasma miR222-3p for discrimination of the PC patients from healthy individuals was reasonable [cut-off value (fold change relative to miR16-5p) = 1.69, area under the curve = 0.73, sensitivity = 0.75 and specificity = 0.74].
genetics_overexpression_suppress	36278816	hsa-mir-204	Gallbladder Neoplasms	In addition, overexpression of FGFR2 restored the cell malignant behavior of GBC cells inhibited by miR
genetics_knock down_suppress	36278814	hsa-mir-761	Osteoarthritis	An in vitro OA model was constructed by treating C28/I2 cells with LPS and treating them with overexpression or knockdown vector of circRNA-MSR, miR-761, and FBXO21, and autophagy inhibitor 3-MA.
other	36278683	hsa-mir-130b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
other	36278683	hsa-mir-26b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
other	36278683	hsa-mir-4649	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
genetics_knock down_promote	36278455	hsa-mir-1285	Carcinoma, Hepatocellular	CONCLUSION: Our results suggested that the knockdown of lncRNA TCTN2 inhibited HCC development by regulating the miR
circulation_biomarker_diagnosis_ns	36278201	hsa-mir-23a	Ischemic Stroke	A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS.
circulation_biomarker_diagnosis_ns	36278201	hsa-mir-99a	Ischemic Stroke	A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS.
other	36277877	hsa-mir-708a	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
other	36277877	hsa-mir-148	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
other	36277877	hsa-mir-148a	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
lncRNA target	36277475	hsa-mir-630	Uterine Cervical Neoplasms	CONCLUSION: Taken together, our findings indicate a novel hypoxia-induced HIF-3alpha and miR-630 regulatory feedback loop contributing to metastasis and progression of cervical cancer cells and suggest that HIF-3alpha and miR-630 might act as potential biomarkers and therapeutic targets for cervical cancer in the future.
genetics_overexpression_suppress	36277474	hsa-mir-29b	Pancreatic Carcinoma	Treatment with the exosomal inhibitor (GW4869) prevented an increase in miR-29b expression and recused the reduced VEGF expression and tube formation and migration abilities of HUVECs cocultured with BxPC3 and AsPC-1 cells that overexpressed miR-29b.
genetics_knock down_promote	36277152	hsa-mir-590	Osteosarcoma	In addition, MALAT1 knockdown upregulated the expression of miR
circulation_biomarker_diagnosis_ns	36277151	hsa-mir-203	Hemangioma	Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females.
circulation_biomarker_diagnosis_ns	36277151	hsa-mir-203a	Hemangioma	Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females.
other	36276993	hsa-mir-146a	Pancreatitis	By using qPCR on our cerulein-induced pancreatitis cell model, it is worth noting that the change of miR-146a-5p expression in inflammation-related miRNAs in AP was predominant. There is potential for miR-146a-5p to serve as a diagnostic marker and therapeutic nucleic acid drug for AP.
genetics_overexpression_promote	36276867	hsa-mir-590	Colorectal Neoplasms	HK2 overexpression or miR
transcription factor target	36276815	hsa-mir-44	Liver Cirrhosis	In addition, TEVs inhibited TGF-beta1 signaling and miR-44 in TEVs had the potential inhibitory effect on liver fibrosis.
genetics_knock down_promote	36276300	hsa-mir-490	Osteosarcoma	3p inhibited cell progression of OS under hypoxia condition, while the effects were attenuated by KLF12 overexpression.
genetics_overexpression_suppress	36276294	hsa-mir-335	Carcinoma, Renal Cell	The overexpression of CCRK partially reversed the inhibitory effects of miR
target gene	36276285	hsa-mir-193a	Pancreatic Neoplasms	miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway.
exosome	36276272	hsa-mir-613	Breast Neoplasms	Exosome-Mediated Transfer of miR-3613-5p Enhances Doxorubicin Resistance by Suppression of PTEN Expression in Breast Cancer Cells.
other	36276146	hsa-mir-16	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-let-7c	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-mir-26a	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-mir-17	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
genetics_knock down_promote	36276139	hsa-mir-200b	Colorectal Neoplasms	Collectively, the loss of exosomal miR-200b-3p in hypoxia CAFs reduced the sensitivity to 5-FU in CRC by targeting HMGB3.
other	36276078	hsa-mir-223	Carcinoma, Non-Small-Cell Lung	MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
lncRNA target	36275896	hsa-mir-409	Cardiomyopathies	3p promotes cardiac fibrosis at least partially through Gpd1.
other	36275894	hsa-mir-451b	Pulmonary Disease, Chronic Obstructive	BACKGROUND: A previous study identified miR-451b as a potential biomarker in smoker with or without chronic obstructive pulmonary disease (COPD). However, the function and molecular mechanisms of miR-451b in the pathogenesis of COPD remain elusive.
exosome	36275890	hsa-mir-124	Psoriasis	miR-124-3p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL-17A Stimulation in Psoriasis.
target gene	36275636	hsa-mir-361	Colorectal Neoplasms	ALDH1A3-Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFbeta Signaling via Sponging miR-361-5p.
transcription factor target	36275459	hsa-mir-203a	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
transcription factor target	36275459	hsa-mir-192	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
transcription factor target	36275459	hsa-mir-148a	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
other	36275122	hsa-mir-130b	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-5100	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-598	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
lncRNA target	36275122	hsa-mir-1307	COVID-19	3p play a critical role in SARS-CoV-2 infection, including via effects on disease progression and severity.
other	36275122	hsa-mir-505	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-34a	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-129	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-181a-2	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-34c	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-193a	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
lncRNA target	36274974	hsa-mir-7847	Sepsis	Our experiments demonstrate that IL17-RA-1 attenuates the sepsis response through the miR3p/MAPK pathway, and this competing endogenous RNA (ceRNA) network may be a potential approach to predict and combat sepsis.
lncRNA target	36274500	hsa-mir-501	Stomach Neoplasms	3p facilitated cell proliferation, migration, and invasion, while inhibiting cell apoptosis in GC by targeting TM4SF1.
other	36274491	hsa-mir-3173	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-629	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-1343	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-9	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
transcription factor target	36274382	hsa-mir-1	Bacterial Infections	Moreover, interventions of miRNA-31 expressions via administration of miRNA-31 agomir reduces lung pathology and bacilli burdens via inducing up-regulation of gene sets involved in biological processes of defense response or cellular and chemical homeostasis in lungs.
other	36274378	hsa-mir-433	Colorectal Neoplasms	3p/E2F3 forms a positive loop which might become a potential biomarker in CRC.
circRNA target	36274319	hsa-mir-146a	Inflammation	Specifically, circRNA-05280 can regulate the level of apoptosis and inflammation of mammary gland by binding miR-146a and releasing the expression of miR-146a on target gene IRAK1.
other	36274229	hsa-mir-223	Granulomatous Disease, Chronic	We engineered lentiviral vectors (LVs) carrying a universal promoter (EF1a) and two myeloid-specific promoters (miR223 and CD68) to drive the expression of green fluorescence protein (GFP) or CYBB, one of the key defective genes causing CGD.
genetics_knock down_suppress	36274134	hsa-mir-10	Osteosarcoma	CONCLUSION: PCED1B-AS1 knockdown may inhibit OS cell proliferation and movement by regulating miR-10 gene methylation.
transcription factor target	36273900	hsa-mir-1281	Osteosarcoma	Hence, our findings suggested that CTB-1 inhibited the cell growth, invasion, and migration of OS by upregulating miR-1281 and inhibiting PPIF expression, thereby providing a possible target drug for OS treatment.
genetics_knock down_promote	36273755	hsa-mir-581	Carcinoma, Hepatocellular	Over-expression or knockdown of miR-581 could alter cell phenotypes caused by Lnc-COX7C-5 in HCC.
genetics_overexpression_promote	36273455	hsa-mir-133a	Adenocarcinoma of Lung	However, the promoting effects of GINS4 overexpression on LUAD could be offset by miR-133a-3p overexpression.
lncRNA target	36273140	hsa-mir-370	Ovarian Neoplasms	CONCLUSION: circ_0025033 might promote ovarian cancer progression via hsa_miR
genetics_knock down_promote	36273122	hsa-mir-103a	Carcinoma, Hepatocellular	Overexpression of EVA1A significantly attenuated the cancer-promoting effects of miR-103a-3p in HCC cells, while knockdown of EVA1A alleviated the mitochondrial dysfunction and apoptosis caused by miR-103a-3p inhibition.
other	36273030	hsa-mir-548	Cakut	Additionally, miR-548 family members have shown substantial enrichment in rare CNVs in CAKUT.
lncRNA target	36272469	hsa-mir-22	Colorectal Neoplasms	3p and plumbagin reduced colony formation and caused apoptotic cell death (detected by Annexin V/PI dual staining), possibly through increased ROS (detection by Dihydroethidium staining) and decreased MMP (detection by MitoTracker Orange staining) in CRC cells.
other	36272464	hsa-mir-142	Hematologic Diseases	In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers.
other	36272464	hsa-mir-142	Siderosis	In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers.
transcription factor target	36272206	hsa-mir-210	Cardiomyopathies	3p facilitated the proliferation of myocardial cells in H/R-treated H9C2 cells by suppressing TFR-mediated ferroptosis, which provided new methods to treat H/R-induced myocardial injury.
other	36272177	hsa-mir-184	Adenocarcinoma of Lung	Finally, the circCENPF/hsa-miR-184 axis was identified as the most promising upstream regulatory pathway of HOXC9 in lung adenocarcinoma.
circulation_biomarker_diagnosis_up	36272155	hsa-mir-122	Intracranial Aneurysm	5p and KLF6 related plasmids was to figure out their roles in cell growth.
genetics_overexpression_promote	36272153	hsa-mir-15	Osteosarcoma	However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells.
genetics_overexpression_promote	36272153	hsa-mir-15a	Osteosarcoma	However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells.
lncRNA target	36272152	hsa-mir-650	Ovarian Neoplasms	The present study investigated the role of miR-650 in ovarian cancer by targeting Kruppel-like factor 12 (KLF12). Unlike miR-650, KLF12 showed a substantial up-regulation in ovarian cancer tissues and cell lines.
lncRNA target	36272150	hsa-mir-873	Osteosarcoma	5p/KLF5 axis confers vital effect on the occurrence and progression of OS, thus providing possible guidance for the clinical treatment of OS.
other	36271618	hsa-mir-206	Myocardial Ischemia	3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia.
other	36271618	hsa-mir-208a	Myocardial Ischemia	3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia.
other	36271413	hsa-mir-185	Leukemia, Lymphocytic, Chronic, B-Cell	Besides, the expression of circ_0002078 and TCF7L1 were significantly elevated and miR3p was obviously decreased in CLL patients.
genetics_GWAS	36270583	hsa-mir-21	Spinal Cord Injuries	This study aims to develop a type of genetically engineered miR21-loaded exosomes that can be entrapped in collagen-I (Col-I) scaffold to repair SCI.
other	36270453	hsa-mir-196c	Myocardial Reperfusion Injury	The mir-196c-3p mimic (mimics) and photothermal nanoparticles (BTN) were co-encapsulated in an injectable Gel (mimics Gel/BTN) with NIR-II light-triggered release.
circulation_biomarker_diagnosis_down	36270080	hsa-mir-155	Carcinoma, Non-Small-Cell Lung	Herein, employing miRNA-155 as a target, a novel integrated concentration and determination system of exosomes (ICDSE) was fabricated for the targeted enrichment of exosomes from the plasma of patients with non-small cell lung cancer and instant downstream analysis of exosomal miRNA.
other	36269619	hsa-mir-4756	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-10a	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-221	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-192	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
lncRNA target	36269529	hsa-mir-425	Osteosarcoma	5p/HMGB2 regulatory axis is a promising target in treating human OS.
lncRNA target	36269411	hsa-mir-4443	Rhabdomyosarcoma	In this study, through experimental verification, we found miR-4443 to be downregulated in cells infected with EV71.
lncRNA target	36269304	hsa-mir-7977	Diabetes Mellitus	Taken together, these findings suggest GO may be a superior auxiliary material for Ad-MSCs to facilitate diabetic wound healing via the Linc00324/miR-7977/STK4 pathway.
lncRNA target	36269211	hsa-mir-128	Neurotoxicity Syndromes	3p/PGC-1alpha axis may be a therapeutic target for PBDE-47 neurotoxicity.
genetics_overexpression_promote	36269185	hsa-mir-92a	Retinal Neovascularization	RESULTS: The overexpression of miR-92a-3p inhibited the development of retinal superficial vascular plexus and deep vascular plexus, decreased the expression of Ki67, and increased the expression of cleaved caspase-3 in isolectin B4-labeled retinal vascular ECs.
transcription factor target	36269185	hsa-mir-92a	Retinal Diseases	CONCLUSIONS: The miR-92a-3p could affect retinal angiogenesis by targeting SGK3 pathway, suggesting that miR-92a-3p may be a potential anti-angiogenic factor for retinal vascular disease.
transcription factor target	36269039	hsa-mir-29c	Stomach Neoplasms	To sum up, miR-29c-3p/MEST signaling pathway suppressed formation of malignant phenotypes of GC, and targeting the signaling pathway may be a new method for treating GC.
circRNA target	36268878	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: circGOLPH3 exerted pro-oncogenic effects through the miR
other	36268280	hsa-mir-143	Adenocarcinoma of Lung	We also identified the lncRNA UCA1/miR3p/CDK1 regulatory axis in LUAD.
genetics_overexpression_suppress	36268275	hsa-mir-22	Colorectal Neoplasms	3p inhibition or FSTL1 overexpression could offset the inhibition of TRPM2-AS downregulation on CRC cells.
other	36268199	hsa-mir-450b	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268199	hsa-mir-155	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268199	hsa-mir-1249	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268034	hsa-mir-585	Stomach Neoplasms	CONCLUSIONS: In conclusion, this study uncovered miR5p impedes gastric cancer proliferation and metastasis by orchestrating the interactions among CREB1, MAPK1 and MITF.
transcription factor target	36268033	hsa-mir-125b	Liver Failure	AIMS: To explore the role and mechanism of miR-125b-5p in the development of liver failure. CONCLUSION: Upregulation of miR-125b-5p can alleviate acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway, and regulation of miR-125b-5p may serve as an alternative intervention for liver failure.
lncRNA target	36267915	hsa-mir-103	Acquired Immunodeficiency Syndrome	We reveal that miRNA-103 mimics, as well as Nutlin-3, an inhibitor of Mdm2-mediated p53 degradation, decrease CCR5-dependent HIV-1 infection.
lncRNA target	36267843	hsa-mir-411	Hemangioma	CONCLUSION: DSCAM-AS1 expedited HA progression via miR5p/TPD52 pathway, which provided a novel therapeutic option for HA treatment.
transcription factor target	36267816	hsa-mir-377	Heart Failure	Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway.
transcription factor target	36267816	hsa-mir-377	Sepsis	Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway.
other	36267811	hsa-mir-124	Myocardial Infarction	3p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated.
lncRNA target	36267792	hsa-mir-671	Thyroid Cancer, Papillary	In summary, circ_0001658 is a carcinogenesis-associated circRNA that regulates PI3K/AKT signaling via the miR
other	36267723	hsa-mir-423	Stomach Neoplasms	The lncRNA TERC promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-423-5p to regulate SOX12 expression.
transcription factor target	36267717	hsa-mir-16	Colorectal Neoplasms	CONCLUSIONS: This is the first study to show that amentoflavone inhibits CRC EMT via the miR-16/HMGA2/beta-catenin pathway.
circulation_biomarker_prognosis_up	36267307	hsa-mir-18a	Esophageal Squamous Cell Carcinoma	Peripheral blood (PB) miR-18a-5p and ATM levels in these participants were quantified via qRT-PCR, and the correlations of the two genes with ESCC patients' clinicopathological characteristics were investigated.
genetics_overexpression_suppress	36267095	hsa-mir-19b	Osteoarthritis	In this study, miR-19b-3p was downregulated in osteoarthritic cartilage tissues and IL-1beta-stimulated primary chondrocytes, and miR-19b-3p overexpression reversed the inhibitory effect of IL-1beta on cell viability, the promotion effects of apoptosis, inflammatory factor secretion and extracellular matrix degradation, whereas the opposite effect was observed with miR-19b-3p inhibitor.
exosome	36266968	hsa-mir-155	Mite Infestations	These results demonstrate that the niche factors in TAME, such as exosomal miRNA-155, regulate the function and polarity of macrophages to facilitate tumor progression.
circulation_biomarker_diagnosis_ns	36266728	hsa-mir-195	Carcinoma, Renal Cell	5p), PDCD5, HDAC3, and serum glucocorticoid-inducible kinase 1 (SGK1) was determined by RT-qPCR and Western blot analysis.
lncRNA target	36266695	hsa-mir-874	Osteosarcoma	CONCLUSION: LncRNA CASC9 promotes cell proliferation and invasion in OS via miR3p/SOX12 axis.
other	36266590	hsa-mir-71	Echinococcosis	Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354).
other	36266590	hsa-let-7	Echinococcosis	Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354).
lncRNA target	36266384	hsa-mir-148a	Squamous Cell Carcinoma of Head and Neck	Finally, via upstream prognosis-related microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) prediction and co-expression analysis, we built an immune-related ceRNA network (LINC00052/hsa-miR-148a-3p/PLAU) related to HNSCC patient prognosis.
circulation_biomarker_diagnosis_up	36265417	hsa-mir-29	Pulmonary Fibrosis	In human peripheral blood from IPF patients decreased miR-29 concentrations were associated with increased mortality in two cohorts potentially identified as a target population for treatment.
genetics_knock down_promote	36265392	hsa-mir-802	Squamous Cell Carcinoma of Head and Neck	miR-802 overexpression reduced the malignant potential of OSCC cells largely by down-regulating MYO6.
transcription factor target	36264388	hsa-mir-21	Osteoarthritis	We compare the efficacy of two treatments, MSC with their miR-21 inhibited through lentiviral transfection and their EV, against inflammation in a new OA animal model.
other	36264136	hsa-mir-616	Vasculitis, Central Nervous System	ABRA showed higher levels of long noncoding RNAs and miR-616.
other	36264049	hsa-mir-106b	Ovarian Neoplasms	Up-regulation of oxidized low-density lipoprotein receptor 1 correlates with decreased miR-106b-5p, miR-93-5p, miR-3129-5p, miR-199b-3p, and miR-4465, higher recurrence rate, and poor prognosis in ovarian cancer.
lncRNA target	36263453	hsa-mir-212	Colorectal Neoplasms	CONCLUSION: CRNDE led to the deterioration of impairment on cognition induced by ISO through suppressing miR5p expression and promoting neuroinflammation.
lncRNA target	36263172	hsa-mir-607	Esophageal Squamous Cell Carcinoma	In the section of mechanism experiments, hsa_circ_0003823 regulated CRISP3 by targeting microRNA-607 (miR-607) to promote progression of ESCC. Conclusions: In this study, we elucidated the function of hsa_circ_0003823 and its role in promoting tumor progression, metastasis and Apatinib resistance of ESCC through miR-607/CRISP3 axis.
genetics_overexpression_promote	36263050	hsa-mir-210	Osteoarthritis	3p overexpression in ECs via adeno-associated virus (AAV) alleviated cartilage degradation, suppressed the type 17 immune response and relieved symptoms by attenuating subchondral Emcn(+) vasculature and subchondral bone remodeling.
genetics_knock down_suppress	36262998	hsa-mir-26a	Esophageal Neoplasms	MiR-26a-5p inhibitor can dramatically limit the ability of LINC00240 knockdown on plate colony formation and relocation of esophageal cancerous cells was demonstrated in colony formation and migration experiments. CONCLUSION: LINC00240 expression is elevated in esophageal cancerous tissues, and knocking down LINC00240 decreases esophageal cancer cell proliferation, clone formation, invasion, and migration via miR-26a-5p.
genetics_knock down_suppress	36262967	hsa-mir-1236	Carcinoma, Hepatocellular	Finally, we found that knockdown of miR
other	36262826	hsa-mir-15a	Endometriosis	This study aims to uncover the role of long non-coding RNA BRAF-activated non-protein coding RNA (lncRNA BANCR)-mediated competing endogenous RNA mechanism in endometrial stromal cell (ESC) proliferation and invasion in EM by regulating miR-15a-5p/TRIM59.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-184	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-16	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-15b	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
lncRNA target	36262353	hsa-mir-875	Osteosarcoma	Targeting the LINC00909/miR
lncRNA target	36262350	hsa-mir-216	Colorectal Neoplasms	The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC.
lncRNA target	36262350	hsa-mir-216b	Colorectal Neoplasms	The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC.
lncRNA target	36262285	hsa-mir-625	Urinary Bladder Neoplasms	OBJECTIVE: This study further explored LINC00958's role in promoting tumor angiogenesis (AG) and oxidative stress (OS) development by inhibiting BC cell autophagy through sponge adsorption of miR
genetics_overexpression_promote	36262247	hsa-mir-1182	Colorectal Neoplasms	FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells.
transcription factor target	36262165	hsa-mir-153	Cardiomegaly	In short, Gm43843 promotes cardiac hypertrophy via miR
lncRNA target	36261179	hsa-mir-194	Gallbladder Neoplasms	CONCLUSIONS: SNHG1 silencing suppressed the viability, proliferation and invasion of GBC cells via targeting miR
lncRNA target	36261177	hsa-mir-141	Pneumonia, Mycoplasma	CONCLUSIONS: MALAT1-201 derived from MSC-Ex regulated the proliferation, apoptosis and migration of HTR8-Svneo cells by targeting miR-141, which indicated a promising therapeutic target for PE.
other	36261176	hsa-mir-145	Colonic Neoplasms	3p negatively modulated the expression of CDK1, thus attenuating the oncogenic effects produced by CDK1 in CC.
lncRNA target	36261079	hsa-mir-144	Schizophrenia	In conclusion, this study revealed that icariin may have therapeutic effects on schizophrenia-like disorders via regulating the miR3p/ATP1B2/mTOR signalling, suggesting that icariin has potential to become an antipsychotic drug.
other	36261031	hsa-mir-3917	Lung Neoplasms	miR-3917 is highly expressed in lung cancer tissues and M2-Ex. M2-Ex can transfer miR-3917 into lung cancer cells and promote lung cancer progression, providing theoretical basis for the diagnosis and effective treatment of lung cancer.
genetics_overexpression_promote	36260870	hsa-mir-126	Adenocarcinoma of Lung	The overexpression of miR
genetics_overexpression_promote	36260870	hsa-mir-1	Adenocarcinoma of Lung	The overexpression of miR
lncRNA target	36260520	hsa-mir-299	Carcinoma, Hepatocellular	Matrine stimulates HCC cell apoptosis and represses the process of EMT and stemness through the miR
genetics_overexpression_promote	36260266	hsa-mir-633	Stomach Neoplasms	Overexpression of miR-633 inhibits the proliferation and migration of GC cells and induces apoptosis and cell cycle arrest at the in G(1) phase.
circulation_biomarker_diagnosis_up	36259475	hsa-mir-21	Hypertension	We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1).
circulation_biomarker_diagnosis_up	36259475	hsa-mir-222	Hypertension	We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1).
genetics_GWAS	36258913	hsa-mir-499	Carcinoma, Non-Small-Cell Lung	SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects.
genetics_GWAS	36258913	hsa-mir-196a	Carcinoma, Non-Small-Cell Lung	SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects.
circulation_biomarker_diagnosis_ns	36258850	hsa-mir-149	Sleep Apnea, Obstructive	This study aimed to examine the serum expression of microRNA
circulation_biomarker_diagnosis_ns	36258850	hsa-mir-149	Obesity	This study aimed to examine the serum expression of microRNA
circulation_biomarker_diagnosis_ns	36258728	hsa-mir-326	Platelet Storage Lesion	Differential miRNA-326 and its target gene, Bcl-xL and Bak, expression levels at different points of platelets storage are promising tools as biomarkers for platelets undergoing PSL in blood banks.
other	36257575	hsa-mir-124	Irritable Bowel Syndrome	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
other	36257575	hsa-mir-124	Visceral Hypersensitivity	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
other	36257575	hsa-mir-124	Cancer-Associated Cachexia	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
lncRNA target	36257574	hsa-mir-152	Depression	PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR
lncRNA target	36257574	hsa-mir-152	Chronic Pain	PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR
genetics_overexpression_promote	36257404	hsa-mir-26a	Diabetic Nephropathies	We determined that miR-26a-5p overexpression ameliorated podocyte injury in DN via binding to 3'-UTR of Trpc6, as evidenced by the markedly reduced activity of luciferase reporters by miR-26a-5p mimic.
lncRNA target	36255597	hsa-mir-140	Esophageal Neoplasms	In addition, DGE identified target genes of miR
lncRNA target	36255069	hsa-mir-513a	Carcinoma, Hepatocellular	These findings unraveled that circ_0003998 elevated 5-FU resistance in HCC by sponging miR-513a-5p to upregulate the level of ARK5, indicating that circ_0003998 might be used as a target to improve 5-FU therapy for HCC.
genetics_knock down_suppress	36255068	hsa-mir-543	Ovarian Neoplasms	Circ_0026123 functionally targeted miR-543, and knockdown of miR-543 reversed the impacts of circ_0026123 deficiency on DDP sensitivity and the malignant behaviors of DDP-resistant OC cells. RAB1A was a target of miR-543, RAB1A overexpression attenuated the inhibitory functions of miR-543 on DDP resistance and the malignant phenotypes of DDP-resistant OC cells.
lncRNA target	36255066	hsa-mir-128	Squamous Cell Carcinoma of Head and Neck	Further research is underway to understand how miR3p regulates oncogenesis in TSCC via MAP2K7 and associated pathways.
other	36254861	hsa-mir-199a	Myocardial Reperfusion Injury	Recent studies have revealed that miR-199a-5p participates in the process of myocardial I/R injury, but the precise roles and molecular mechanisms of miR-199a-5p in myocardial I/R injury remain not well-studied. Herein, the present study aimed to explore the function and mechanisms by which miR-199a-5p regulates whether miR-199a-5p contributes to ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reoxygenation (OGD/R) injury, an in vitro model of myocardial I/R injury focusing on Akt/eNOS signaling pathway.
transcription factor target	36254861	hsa-mir-199a	Hypoxia-Ischemia, Brain	In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway.
lncRNA target	36254861	hsa-mir-199a	Siderosis	In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway.
transcription factor target	36254623	hsa-mir-371a	Neoplasms, Germ Cell and Embryonal	Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression.
transcription factor target	36254623	hsa-mir-371a	Seminoma	Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression.
other	36254341	hsa-mir-184a	Angioedemas, Hereditary	AKT2, the mRNA regulated by the differentially-expressed miR-184A, was also associated with HAE attacks.
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-4530	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-125a	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-92a-2	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
other	36254230	hsa-mir-192	Carcinoma, Hepatocellular	RESULT: CARMN was considered to be the potential upstream lncRNA for the hsa-miR5p/LOXL2 axis in HCC.
transcription factor target	36254157	hsa-mir-181d	Optic Nerve Injuries	CONCLUSION: miR-181d-5p can protect against the deterioration of TON by inhibiting RGCs death, astrocyte development, oxidative stress, and inflammation by targeting NFIA.
lncRNA target	36254053	hsa-mir-92a	Carcinoma, Non-Small-Cell Lung	To assess the potential prognostic value of miR-92a as a new biomarker in non-small cell lung cancer (NSCLC) via clinical evaluation, a total of 100 patients with NSCLC admitted to the Respiratory and Intensive Care Department of Suining Central Hospital in Sichuan Province between August 2007 and April 2020 were retrospectively analyzed.
exosome	36253857	hsa-mir-493	Asthma, Allergic	5p, thus DC-derived exosomal miR
genetics_knock down_promote	36253542	hsa-mir-1270	Adenocarcinoma of Lung	We show that the loss of miRNAs (miR)
genetics_overexpression_promote	36252912	hsa-mir-451a	Thyroid Cancer, Papillary	Overexpression of DCBLD2 and AKT1 could restore the effect of miR-451a on PTC cells.
other	36252562	hsa-mir-138	Muscular Atrophy, Spinal	Silencing of miRNA-138 increased neuronal apoptosis and spinal cord atrophy significantly.
genetics_knock down_suppress	36252562	hsa-mir-138	Myelodysplastic Syndromes	Comparatively, knockdown of miRNA-138 downregulated Shh levels in myelodysplastic regions.
circulation_biomarker_diagnosis_ns	36252485	hsa-mir-214	Hashimoto Disease	LINC00842 functioned as a miR-214 sponge in HT patients and thyroid epithelial follicular cells. These findings concluded that AMIO-drove XBP1s aggravated endoplasmic reticulum stress and apoptosis in HT via modulating LINC00842/miR-214/FASL axis, providing a new sight for the therapeutic strategy of AMIO-induced HT.
genetics_knock down_suppress	36252478	hsa-mir-450b	Acute Lung Injury	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_suppress	36252478	hsa-mir-450b	Systemic Inflammatory Response Syndrome	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_suppress	36252478	hsa-mir-450b	Sepsis	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_promote	36252429	hsa-mir-335	Ischemic Stroke	CONCLUSION: Circ_0101874 knockdown alleviated OGD-induced neuronal cell injury by suppressing PDE4D via regulating miR
transcription factor target	36252394	hsa-mir-26a	Endometritis	miR-26a and MAP3K8 may be a promising biomarker and therapeutic target for dairy cow endometritis.
lncRNA target	36252156	hsa-mir-377	Esophageal Squamous Cell Carcinoma	The results suggest that the molecular targeting of the lncRNA NEAT1 and miR-377/E2F3 axis could prove beneficial in the management of esophageal cancer.
genetics_knock down_suppress	36252137	hsa-mir-1249	Hypertension, Pulmonary	In rats, the repression of microR-1249 in eEVs by microR-1249 inhibitor, histone deacetylase 10 overexpression, or calcium-sensing receptor knockout profoundly inhibited the proliferative capacities and diminished apoptosis-resistance of pulmonary artery smooth muscle cells and pulmonary hypertension development in rats intravenously administrated with eEVs preparation from cigarette smoke extract-treated pulmonary artery endothelial cells. CONCLUSIONS: Cigarette smoke-enriched microR-1249 in endothelial extracellular vesicles facilitates the hyperproliferative and antiapoptotic status of pulmonary artery smooth muscle cells promoting pulmonary hypertension evolution through the inhibition of histone deacetylase 10-NFkappaB-calcium-sensing receptor cascade.
circulation_biomarker_prognosis_up	36251659	hsa-mir-1246	Dengue	CONCLUSION: Our study indicated that circulating miRNAs, especially miR
genetics_overexpression_promote	36251494	hsa-mir-450b	Squamous Cell Carcinoma of Head and Neck	miR-450b was found to be overexpressed in OSCC animal samples, HNSCC samples and human OSCC cells.
circulation_biomarker_diagnosis_up	36251230	hsa-mir-502	Alzheimer Disease	Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD.
circulation_biomarker_diagnosis_up	36251230	hsa-mir-200a	Alzheimer Disease	Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD.
transcription factor target	36251141	hsa-mir-19b	Arthritis, Rheumatoid	GA upregulated miR-19b-3p expression, downregulated RAF1 expression, inhibited ERK1/2 phosphorylation, induced MH7A cell apoptosis and suppressed MH7A cell invasion and migration (P&lt;0.05 or P&lt;0.01).
other	36250950	hsa-mir-149	Stomach Neoplasms	Rescue assays indicated that circBGN regulates GC cell proliferation and invasion by upregulating miR5p/IL6 axis output.
circulation_biomarker_diagnosis_up	36250874	hsa-mir-21	Hypoxia	To test this hypothesis, we exposed male rats to 6 h of 12% O(2) and measured circulating levels of ET-1 and miR-21, pre, during, and posthypoxia.
genetics_knock down_suppress	36250827	hsa-let-7c	Abortion, Habitual	3p, and miR-let-7c expression levels in plasma samples of patients with idiopathic recurrent pregnancy loss (iRPL) and healthy subjects and to evaluate their potential diagnostic value in diagnosis of iRPL.
genetics_overexpression_promote	36250561	hsa-mir-499	Angelman Syndrome	5p overexpression could promote the proliferation and migration of MOVAS.
other	36250561	hsa-mir-499	Cardiovascular Diseases	The miR5p/SOX6 axis may present a promising therapeutic implication for the prevention and treatment of cardiovascular diseases.
genetics_overexpression_promote	36250558	hsa-mir-186	Myocardial Infarction, Acute	Rescue experiments revealed that miR-186 overexpression or YY1 suppression partially reversed the roles of ox-EVs overexpressing CLDN10-AS1 in ox-LDL-induced VEC injury.
other	36250452	hsa-mir-574	Osteosarcoma	3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.
lncRNA target	36250437	hsa-mir-128	Epilepsy	3p attenuates penicillin-induced cell injury and inflammation in astrocytes by targeting MAPK6, thus providing a protective role in epilepsy.
lncRNA target	36250223	hsa-mir-338	Opitz GBBB Syndrome, X-Linked	3p/MEF2C is a prospective target for OS treatment.
other	36250210	hsa-mir-21	Pre-Eclampsia	The upregulation of placental miR21 abundance by placenta-specific nanoparticles loaded with agomir-miR21 during placentation interfered with PPP2R2B and activated the Hippo pathway in the placenta, leading to a PE-like phenotype. Thus, aberrant elevation of miR21 impairs EVT mobility by modulating the PP2A Bbeta/Hippo axis, which is one of the causes of PE.
other	36250208	hsa-mir-149	Colitis	3p in colon inflammation, which may serve as an attractive therapeutic tool for colitis or IBD, and even colitis-associated carcinoma.
circulation_biomarker_diagnosis_down	36250025	hsa-mir-335	Ischemic Stroke	Conclusion: Our results revealed that serum TUG1, miR-21, NBAT1, and miR-335 could be promising molecular diagnostic markers for AIS as these biomarkers could discriminate between AIS patients and healthy controls.
other	36249798	hsa-mir-143	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
other	36249798	hsa-mir-181	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
other	36249798	hsa-mir-152	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
lncRNA target	36249712	hsa-mir-432	Carcinoma, Non-Small-Cell Lung	circPTN regulates the malignant progression of NSCLC cells through targeting the miR
other	36249345	hsa-mir-185	Cataract, Congenital Zonular, with Sutural Opacities	Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs.
other	36249345	hsa-mir-22	Cataract, Congenital Zonular, with Sutural Opacities	Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs.
genetics_knock down_promote	36248798	hsa-mir-216a	Squamous Cell Carcinoma of Head and Neck	An miR-216a-5p inhibitor reversed the effect of HCP5 knockdown on the proliferation and migration and invasive ability of LSCC cells.
lncRNA target	36248732	hsa-mir-181a	Autoimmune Diseases	Collectively, our results reveal a previously unappreciated T cell-intrinsic role of miR-181a-5p in restraining autoimmunity and may provide a potential therapeutic target for uveitis treatment.
genetics_overexpression_promote	36248732	hsa-mir-181a	Uveitis	Th17 cells overexpressing miR-181a-5p exhibited impaired ability to induce pathogenesis in an adoptive transfer model of experimental autoimmune uveitis (EAU).
target gene	36248434	hsa-mir-378	Leukemia, Myeloid	LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis.
lncRNA target	36248429	hsa-mir-511	Alzheimer Disease	CONCLUSION: Moxibustion at acupoints of the governor vessel can suppress the lncRNA Six3os1 expression, promote cell autophagy, accelerate Abeta1-42 clearance and alleviate cognitive dysfunction of AD mediated by the PI3K/AKT/mTOR signaling pathway through the lncRNA Six3os1/miR
other	36248425	hsa-mir-6511b	Lymphoma	LncHOTAIR/hsa-miR-6511b-5p/ATG7 could regulate the proliferation, apoptosis, and autophagy of Raji and BJAB lymphoma cells.
lncRNA target	36248422	hsa-mir-200	Colorectal Neoplasms	In previous mechanistic studies, we found that the miR-200s expression in CRC is associated with L-OHP sensitivity through regulation of MDR1/p-gp and the downstream c-JunN-terminal kinase (JNK) signaling pathway.
target gene	36248404	hsa-mir-338	Ovarian Neoplasms	Circ_0109046 silencing impaired the proliferation, migration, and invasion of ovarian cancer cells through negatively regulating miR-338-3p in vitro
other	36248377	hsa-mir-1248	Pituitary Adenoma, Non-Functioning	Hsa-miR-1248 showed exceptional connectivity in the ceRNA regulatory network, which could be closely related to the invasiveness of NFPAs.
epigenetics	36248294	hsa-mir-205	Parkinson Disease	MiR-205 Regulates LRRK2 Expression in Dopamine Neurons in Parkinson's Disease through Methylation Modification.
exosome	36248244	hsa-mir-106a	Glioma	However, hypoxic glioma cell-derived exosomes markedly promoted the proliferation and suppressed the apoptosis in TMZ-treated glioma cells, and miR-106a-5p inhibitor was able to abolish these phenomena.
lncRNA target	36248191	hsa-mir-652	Atherosclerosis	3p regulates the lipid metabolism of macrophages to alleviate atherosclerosis by inhibiting TP53 expression.
transcription factor target	36247625	hsa-mir-408a	Dehydration	Finally, miR408a was selected for functional analysis and demonstrated to be a negative regulator of drought response, mainly through regulation of reactive oxygen species accumulation in the maize root system.
circulation_biomarker_diagnosis_ns	36247409	hsa-mir-1	Breast Neoplasms	In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality.
circulation_biomarker_diagnosis_ns	36247409	hsa-mir-29b	Breast Neoplasms	In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-223	Diabetes Mellitus, Type 2	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-223	Periodontal Diseases	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-200b	Periodontal Diseases	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-200b	Diabetes Mellitus, Type 2	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
other	36247288	hsa-mir-7706	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
other	36247288	hsa-mir-877	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
other	36247288	hsa-mir-128	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
lncRNA target	36247255	hsa-mir-223	Cardiomyopathies	Further experiments demonstrated that FGD5-AS1 modulated Akt activity to reduce myocardial injury through miR3p.
lncRNA target	36247255	hsa-mir-223	Myocardial Infarction	3p/Akt pathway is involved in AMI, suggesting that FGD5-AS1 may act as a potential biomarker and therapeutic target for AMI.
target gene	36247254	hsa-mir-145	Osteosarcoma	LncRNA UCA1 accelerates osteosarcoma progression via miR-145 and Wnt/β-catenin pathway.
genetics_knock down_suppress	36247250	hsa-mir-486a	Endometrial Hyperplasia	Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia.
genetics_knock down_promote	36247250	hsa-mir-486a	Inflammation	Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia.
circulation_biomarker_diagnosis_up	36247238	hsa-mir-197	Hypertension, Pregnancy-Induced	RESULTS: In pregnant women with PIH, serum UCA1 and HDAC2 expression was downregulated and serum miR
other	36246958	hsa-mir-335	Pulmonary Arterial Hypertension	Our work highlights the role of miR5p and calumenin in RV remodeling and may lead to the development of novel therapeutic strategies for right heart failure.
other	36246623	hsa-mir-29c	Carcinoma, Hepatocellular	The DUXAP8-miR-29c-FANCD2 and LINC00511-miR-29c-FANCD2 axes were identified as the most likely ncRNA-associated upstream regulatory axis of FANCD2 in HCC.
lncRNA target	36246567	hsa-mir-4500	Stomach Neoplasms	HEIH promotes gastric cancer development by inhibiting miR-4500.
lncRNA target	36246563	hsa-mir-96	Colorectal Neoplasms	Analysis of LINC01314 and miR-96 Expression in Colorectal Cancer Patients via METHODS: A tissue microarray (TMA) containing 76 individual colorectal tumor samples and 28 adjacent normal samples was constructed, and the expression levels of LINC01314 and miR-96 were detected by fluorescence in situ hybridization.
lncRNA target	36246560	hsa-mir-21	Respiratory Distress Syndrome	Thus, the camk2g/miR3p/lncRNA/circRNA network, CXCL10/CXCR3, and IL-17 signaling pathways might provide novel insights and targets for further studying the lung injury mechanism and clinical treatment.
circulation_biomarker_prognosis_up	36245984	hsa-mir-651	Carcinoma, Hepatocellular	RESULTS: Serum miR-3651 was found to be higher in HCC patients than in LC patients and normal persons, and it presented a sensitivity and specificity of 57.14% and 94.00%, respectively, in forecasting the occurrence of HCC in LC patients.
target gene	36245704	hsa-mir-361	Prostatic Neoplasms	lncRNA MIAT participated in prostate cancer by regulating cell proliferation and apoptosis via miR-361-3p/CCAR2 axis.
genetics_overexpression_promote	36245426	hsa-mir-377	Endometrial Neoplasms	3p, and overexpression of miR
genetics_overexpression_promote	36245214	hsa-mir-378a	Stomach Neoplasms	RESULTS: We report the first evidence that miR-378a-3p is downregulated in GC, whereas its overexpression inhibits proliferation, invasion, and migration as well as promotes apoptosis in GC cells.
genetics_overexpression_promote	36245088	hsa-mir-187	Prostatic Neoplasms	Prostate cancer cells were then exposed to BMSC-exos that were treated with either miR-187 mimic/inhibitor or CD276 overexpression for pinpointing the in vitro and in vivo effects of exosomal miR-187.
lncRNA target	36244909	hsa-mir-21	Acute Kidney Injury	CONCLUSIONS: ADSC-EVs inhibited inflammation and TEC pyroptosis and promoted TEC repair in AKI by mediating miR
lncRNA target	36244580	hsa-mir-709	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Ligustrazine targets circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.
other	36244127	hsa-mir-223	Endometriosis	Given the fact that miRNA-223 was previously shown to be upregulated in these cells and that this upregulation has been linked to epithelial-to-mesenchymal transition (EMT) during endometriosis, this study aimed to further explore the expression of miRNA-223, its effect in endometriosis, and the mechanisms underlying its effects. CONCLUSION: miRNA-223 expression decreased in endometrial SCs from endometriosis patients, which may facilitate the differential regulation of EMT during endometriosis.
other	36243928	hsa-mir-218	Pulmonary Disease, Chronic Obstructive	The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE.
other	36243928	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE.
genetics_overexpression_suppress	36243896	hsa-mir-486	Colorectal Neoplasms	In CRC cell lines, demethylation and overexpression of miR
genetics_overexpression_suppress	36243896	hsa-mir-34c	Colorectal Neoplasms	In CRC cell lines, demethylation and overexpression of miR
lncRNA target	36243865	hsa-mir-610	Ovarian Neoplasms	This study further demonstrated that circ_0000144 downregulated ELK3 levels by sponging miR-610 in ovarian cancer cells. CONCLUSION: Our data indicate that circ_0000144 could enhance the carcinogenesis of ovarian cancer by specifically targeting miR-610, which may serve as a novel target for the diagnosis and prognosis of ovarian cancer.
exosome	36243800	hsa-mir-140	Ossification of Posterior Longitudinal Ligament	CONCLUSIONS: We found that exosomal miR
lncRNA target	36243708	hsa-mir-124	Cartilage Diseases	3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA.
lncRNA target	36243708	hsa-mir-124	Osteoarthritis	3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA.
other	36243683	hsa-let-7a	Esophageal Squamous Cell Carcinoma	The decrease in let-7a expression level led to the increased expression level of CCR7 in ESCC cells, consequently increasing their invasive ability and malignancy and resulting in a worse prognosis for ESCC patients.
lncRNA target	36243115	hsa-mir-186	Carcinoma, Hepatocellular	miR-186 was significantly lower while IGF2BP1 was elevated in cancerous tissues from ten HCC patients compared to five healthy controls. SIGNIFICANCE: miR-186 may exert tumor suppressor effects in HCC by repressing oncogenic lncRNAs H19, SNHG3, and FOXD2-AS1 through its effect on IGF2BP1.
lncRNA target	36242967	hsa-mir-93	Acute Lung Injury	Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI.
lncRNA target	36242967	hsa-mir-93	Sepsis	Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI.
lncRNA target	36242914	hsa-mir-23a	Achard-Thiers syndrome	Hnf4alphaos also promoted the stability of Hnf4alpha mRNA through an RNA/RNA duplex, leading to the transcriptional activation of miR-23a and miR-23a depletion was required for PGC1alpha function in hepatoprotective effects on HIRI. Together, our findings reveal that Hnf4alphaos elevation in HIRI leads to severe liver damage via Hnf4alphaos/Hnf4alpha/miR-23a axis-mediated PGC1alpha inhibition.
genetics_knock down_promote	36242728	hsa-mir-186	Carcinoma, Hepatocellular	5p-mediated anti-tumor effects in HCC cells, whereas KLF7 knockdown reversed the promotive effects of NUTM2A-AS1.
other	36242602	hsa-mir-146a	Polycythemia Vera	Thrombotic risk did not depend on JAK2 rs12343867, TERT rs2736100, OBFC1 rs9420907 SNV, however, we found a novel strong tendency towards statistical significance between the CC genotype miR-146a rs2431697 and thrombosis.
lncRNA target	36242511	hsa-mir-130a	Renal Tubular Oxidative Injury	When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated.
lncRNA target	36242511	hsa-mir-130	Renal Tubular Oxidative Injury	When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated.
circRNA target	36242088	hsa-mir-338	Osteoarthritis	CONCLUSION: Circ_0008365 alleviates IL-1beta-induced CHON-001 cell damage through the miR3p/SOX9 axis, which suggested that circ_0008365 might be a new therapeutic target for OA.
circRNA target	36241975	hsa-mir-182	Carcinoma, Hepatocellular	CONCLUSIONS: Taken together, circ_0003570 suppresses the development of HCC by modulating miR5p/STARD13 axis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-145	Acute Coronary Syndrome	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-145	Coronary Stenosis	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-143	Coronary Stenosis	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-143	Acute Coronary Syndrome	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circRNA target	36241055	hsa-mir-1183	Triple Negative Breast Neoplasms	We found that hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT.
lncRNA target	36240611	hsa-mir-155	Mucocutaneous Lymph Node Syndrome	Through the relationships of TFs and hsa-miR
lncRNA target	36240130	hsa-mir-9	Diabetes Mellitus	These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9.
lncRNA target	36240130	hsa-mir-9	Cardiomyopathies	These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9.
lncRNA target	36240080	hsa-mir-134	Seizures	These findings suggest that targeting miR-134 does not have therapeutic applications in DS.
transcription factor target	36239618	hsa-mir-155	Myocardial Reperfusion Injury	Meanwhile, SL decreased miR-155 level, inhibited M1 macrophage polarization and inflammation.
lncRNA target	36239568	hsa-mir-936	Carcinoma, Non-Small-Cell Lung	CONCLUSION: miR-936 targets GPR78 and improves the sensitivity of NSCLC cells to cisplatin via the Galphaq Rho GTPase pathway.
other	36239555	hsa-mir-516a	Carcinoma, Hepatocellular	PNPLA3 rs738409 GG carriers affect miR-516a-3P expression in HCV, and this may highlight a new mechanism in liver disease.
circulation_biomarker_diagnosis_ns	36239547	hsa-mir-4496	Esophageal Squamous Cell Carcinoma	Next, EC cells were cocultured with EVs, followed by lentivirus transduction and plasmid transfection for studying the role of TEVs-AC116025.2 in EC cells in relation to miR-4496 and SEMA5A.
lncRNA target	36239525	hsa-mir-135a	Colitis	CONCLUSION: This study shows that circSMAD4 regulates the progression of experimental colitis via the miR-135a-5p/JAK2 signaling axis and it may be a potential therapeutic target.
lncRNA target	36238993	hsa-mir-143	Triple Negative Breast Neoplasms	3p could be potential therapeutic targets for TNBC.
genetics_overexpression_suppress	36238848	hsa-mir-5590	Carcinoma, Renal Cell	Of note, overexpression of ROCK2 effectively reversed the regulatory effects of miR
target gene	36238844	hsa-mir-29a	Carcinoma, Non-Small-Cell Lung	miR-29a-3p inhibits the malignant characteristics of non-small cell lung cancer cells by reducing the activity of the Wnt/β-catenin signaling pathway.
other	36238488	hsa-mir-494	Osteosarcoma	3p, and TRPS1 might be a characteristic molecule for assessing the prognostic value of OS patients.
other	36238484	hsa-mir-146a	Campomelia Cumming type	After ECT treatment, the cognitive impairment was ameliorated in CUMS rats accomplished with decreased miR-146a-5p and increased NF-kappaB level.
lncRNA target	36238484	hsa-mir-146a	Neurotic Disorders	Finally, compared with ECT treatment, DEX injection could protect against depression-like behaviors by increasing miR-146a-5p level and inactivated NF-kappaB pathway. Overall, ECT-induced cognitive impairment in depression rats could be ameliorated by DEX injection via miR-146a-5p/NF-kappaB axis.
genetics_GWAS	36238483	hsa-mir-204	Diabetic Retinopathy	5p in order to participate in the pathogenetic process of DR.
lncRNA target	36238473	hsa-mir-223	Optic Nerve Glioma	3p plays an inhibitory role in ONG development by regulating NLRP3 to inhibit the proliferation of ONG cells and promote apoptosis.
other	36238196	hsa-mir-5120	Non-alcoholic Fatty Liver Disease	CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD.
other	36238196	hsa-mir-5120	Diabetes Mellitus, Type 2	CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD.
circulation_biomarker_diagnosis_ns	36237545	hsa-mir-23b	Colorectal Neoplasms	Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues.
circulation_biomarker_diagnosis_ns	36237545	hsa-mir-194	Colorectal Neoplasms	Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues.
other	36237258	hsa-mir-29c	Squamous Cell Carcinoma of Head and Neck	The ceRNA regulatory network MIR193BHG-miR-29c-3p-SFXN3 was identified as one of the potential biological regulatory pathways of HNSC. CONCLUSIONS: By performing ceRNA analysis, our study demonstrated that MIR193HG-miR-29c-3p-SFXN3 is significantly involved in HNSC, and this action axis markedly affect the therapeutic effect and prognosis.
genetics_GWAS	36237193	hsa-mir-146a	Diabetes Mellitus, Type 2	CONCLUSION: The results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians.
transcription factor target	36237168	hsa-mir-690	Muscular Atrophy	CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing.
transcription factor target	36237168	hsa-mir-690	Aicardi-Goutieres syndrome 5	CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing.
lncRNA target	36234731	hsa-mir-125b	Glioma	To solve this problem, we co-encapsulated DOX and endogenous tumor suppressor miR-125b into nanoparticles (NPs) by nanoprecipitation methods, and passively targeted them into glioma cells. In vitro experiments show that miR-125b and DOX can be effectively encapsulated into nanoparticles with different ratios, and by targeting YES proto-oncogene 1 (YES1), they can affect the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/p53 pathway and induce brain glioma cell apoptosis.
genetics_overexpression_suppress	36233263	hsa-mir-26a	Pulmonary Arterial Hypertension	5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs.
genetics_overexpression_suppress	36233263	hsa-mir-486	Pulmonary Arterial Hypertension	5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs.
lncRNA target	36233075	hsa-mir-203	Breast Neoplasms	Notably, miR-203 and Caveolin 1 (CAV1) have also been found to play a role in breast cancer. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the HOTAIR/miR-203/CAV1 axis, which complemented the role network of HOTAIR as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy.
lncRNA target	36232922	hsa-mir-139	Colorectal Neoplasms	3p-transfected cells revealed 29 putative targets regulated by miR
other	36232660	hsa-mir-199a	Breast Neoplasms	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-151a	Arm Lymphedema	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-199a	Arm Lymphedema	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-151a	Breast Neoplasms	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
lncRNA target	36232606	hsa-mir-221	Carcinoma, Hepatocellular	The miR-221/AEG-1 axis silencing induces apoptosis and G2/M phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, RB, and PTEN and downregulating LSF, LC3A, Bcl-2, OPN, MMP9, PI3K, and Akt in HCC cells.
other	36232605	hsa-mir-140	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-708	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-183	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-766	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
genetics_GWAS	36232465	hsa-mir-166	Plant Poisoning	qRT-PCR analysis of 29 related genes suggested that defects of the OsDRB2-miR166-OsHBs pathway could play an important role in formation of the rolled leaf phenotype of rl89, in which OsDRB2 mutation reduced miR166 accumulation, resulting in elevated expressions of the class III homeodomain-leucine zipper genes (such as OsHB1, 3 and 5) involved in leaf polarity and/or morphology development.
other	36232448	hsa-mir-181a	Glioma	Therefore, miR-181a is a unique molecule that plays an important role in gliomagenesis, and is also associated with changes in patients' quality of life.
other	36231141	hsa-mir-100	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group.
transcription factor target	36231141	hsa-mir-155	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Targeting PERV with CRISPR/Cas9 resulted in reduced expression of PERV mRNA transcripts and increased miR-155 in the Endo-EVs, and supplementing these in embryos reduced embryo attachment.
other	36231141	hsa-mir-132	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Cardiomegaly	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Pulmonary Fibrosis	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Diabetic Cardiomyopathies	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
lncRNA target	36231079	hsa-mir-92a	Pulmonary Fibrosis	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
lncRNA target	36231079	hsa-mir-92a	Cardiomegaly	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
lncRNA target	36231079	hsa-mir-92a	Diabetic Cardiomyopathies	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
other	36231008	hsa-mir-210	Diabetes Mellitus, Type 2	5p).
other	36231008	hsa-mir-210	Obesity, Morbid	5p).
other	36231008	hsa-mir-206	Obesity, Morbid	5p).
other	36231008	hsa-mir-206	Diabetes Mellitus, Type 2	5p).
other	36230970	hsa-mir-93	Colorectal Neoplasms	CONCLUSION: In summary, our result reveals the novel mechanism in which m(6)A-mediated HNF1A-AS1/IGF2BP2/CCND1 axis promotes CRC cell cycle progression, along with competitively sponging miR5p to upregulate CCND1, demonstrating its significant role in cell cycle regulation and suggesting that HNF1A-AS1 may act as a potential prognostic marker of colorectal cancer in the future.
circulation_biomarker_diagnosis_up	36230923	hsa-mir-17	Pneumonia	5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum.
circulation_biomarker_diagnosis_up	36230923	hsa-mir-193a	Pneumonia	5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum.
circulation_biomarker_diagnosis_up	36230658	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	We analyzed the expression levels and examined the clinical significance of immunoregulatory miRNAs involved in immune checkpoint regulation (miR-34a, miR-200b, miR-200c), T-cell activity (miR-155), and the function of myeloid-derived suppressive cells (MDSCs) (miR-223) or regulatory T lymphocytes (Tregs) (miR-146a), in patients with advanced NSCLC (N = 69) treated with anti-PD-1 (Nivolumab) immunotherapy as 2nd or 3rd line of treatment therapy. Our findings suggest that alterations in circulating miR-200c and miR-34a expression levels are associated with the response and outcome in patients with advanced NSCLC treated with anti-PD1 immunotherapy.
other	36229758	hsa-mir-660	Carcinoma, Non-Small-Cell Lung	Circ_0060967 facilitates proliferation, migration, and invasion of non-small-cell lung cancer cells by sponging miR-660-3p/UBN2.
circulation_biomarker_diagnosis_down	36229729	hsa-mir-147b	Leukemia, Myeloid, Acute	miR-147b was negatively correlated with MAFG-AS1 in the serum and bone narrow of AML cases.
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-483	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-1277	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-152	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
other	36228560	hsa-mir-21	Mucocutaneous Lymph Node Syndrome	Moreover, the proposed MLN-MB could detect the miRNA-21 in complex matrixes stably.
genetics_overexpression_suppress	36228497	hsa-mir-135a	Breast Neoplasms	Overexpression of BAG3 reversed the impacts of miR-135a-5p on the malignant biological behaviors of BC cells.
lncRNA target	36228430	hsa-mir-155	Influenza in Birds	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
lncRNA target	36228430	hsa-mir-155	Newcastle Disease	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
lncRNA target	36228430	hsa-mir-155	Bursitis	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
circulation_biomarker_diagnosis_up	36228356	hsa-mir-221	Depression	3p in the hippocampus and serum of O(3) treated group.
other	36228348	hsa-let-7	Head and Neck Neoplasms	In this study, we aimed to investigate polymorphic alterations of the let-7 miRNA binding site (rs61764370) in the 3'UTR region of the KRAS gene as a predictive biomarker for head and neck cancer (HNC) and to evaluate its association with clinicopathological parameters.
epigenetics	36228259	hsa-mir-130b	Pediatric Obesity	Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children.
epigenetics	36228259	hsa-mir-146b	Pediatric Obesity	Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children.
lncRNA target	36227683	hsa-mir-19a	Cerebral Infarction, Acute	Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction.
lncRNA target	36227683	hsa-mir-19a	Brain Ischemia	Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction.
circulation_biomarker_diagnosis_ns	36227679	hsa-mir-146a	Depression, Post Stroke	Compared with that of N-PSD patients, serum miR-146a-5p levels in PSD patients were significantly increased (P<0.05).
lncRNA target	36227673	hsa-mir-194	Laryngeal Neoplasms	5p could reduce the number of laryngeal cancer cells passing through the basement membrane and their invasion ability.
other	36227666	hsa-mir-34a	Neuroblastoma	This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma.
other	36227666	hsa-mir-584	Neuroblastoma	This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma.
circulation_biomarker_diagnosis_up	36227663	hsa-mir-7	Colorectal Neoplasms	It was concluded that modulation of miR-7 in rats with colorectal cancer and HP infection enables regulation of the Akt / GSK-3 beta/beta- Catenin pathway to improve serum inflammation condition and alleviate HP infection in rats, which played a better role in intervention.
genetics_overexpression_promote	36227662	hsa-mir-889	Diabetes, Gestational	The high glucose-induced human trophoblast cells HTR-8/SVneo were adopted to stimulate the GDM model in vitro (HG group) and were transfected with lentivirus to silence circ-PNPT1 (si-circ-PNPT1 group) and mimic to overexpress miR
circRNA target	36227499	hsa-mir-134	Thyroid Cancer, Papillary	5p served as a tumor repressor in PTC by targeting FSTL1.
transcription factor target	36227355	hsa-mir-181c	Sepsis	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
transcription factor target	36227355	hsa-mir-181c	Acute Kidney Injury	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
transcription factor target	36227355	hsa-mir-181c	Burns	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
genetics_knock down_suppress	36227295	hsa-mir-484	Kidney Calculi	Taken together, these findings suggest that miR-484 overexpression may be a potential inhibitor of RTEC proliferation and CaOx crystallization through a VDR/FoxO1 regulatory axis, providing a novel therapeutic target for the treatment of kidney stone.
lncRNA target	36227173	hsa-mir-22	Vascular Diseases	These findings suggested that PA inhibits VSMC switch to synthetic phenotype through upregulation of miR-22 thereby inhibiting EVI1, and correcting the dysregulation of miR-22/EVI1 or PA metabolism is a potential treatment to vascular diseases.
other	36227151	hsa-mir-101	Adenocarcinoma of Lung	The most promising upstream ncRNA-associated pathway of KIF14 in LUAD was determined to be GSEC/TYMSOS-hsa-miR3p axis according to the starBase and The Cancer Genome Atlas databases.
other	36227125	hsa-mir-422a	Glioma	In this study, based on the glioblastoma microarray profiles, we identified the upstream circTOP2A, which completely bound to miR-422a and was co-expressed with the RPN2.
other	36227097	hsa-mir-200c	Diabetic Nephropathies	The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction.
other	36227097	hsa-mir-200	Diabetic Nephropathies	The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction.
exosome	36226722	hsa-let-7b	Ovarian Neoplasms	We performed coculture experiments using ID8-VEGF ovarian cancer cells to demonstrate EV-mediated propagation of tumor suppressor miRNA Let7b administered with hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles.
lncRNA target	36226520	hsa-mir-486	Gaucher Disease	5p inhibits GA inflammatory response via modulating FOXO1.
other	36226317	hsa-mir-211	Cerebral Hemorrhage	BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH.
other	36226317	hsa-mir-198	Cerebral Hemorrhage	BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH.
lncRNA target	36226250	hsa-mir-1271	Uterine Cervical Neoplasms	Overall, this study showed that FAM201A promoted cervical cancer progression and metastasis by targeting the miR5p/FLOT1 axis-induced Wnt/beta-catenin pathway.
transcription factor target	36225912	hsa-mir-10a	Acquired Immunodeficiency Syndrome	Thus, inhibition of miR-10a-5p enhanced HIV-specific CD8(+) T cell capacity in progressors.
transcription factor target	36225178	hsa-mir-505	Myocarditis	In this study, miR5p is related to MIRI pathogenesis, which provides the new possible targeted therapy in patients with MIRI.
virus_miRNA	36225172	ebv-mir-BART5	Nasopharyngeal Carcinoma	Inhibiting expression of EBV-miR-BART5-3p might reduce the risk of developing nasopharyngeal cance
lncRNA target	36224673	hsa-mir-3679	Carcinoma, Hepatocellular	Moreover, miRNA-3679 promotes the proliferation of HCC cells and inhibits their apoptosis by suppressing ZADH2.
lncRNA target	36224588	hsa-mir-155	Colonic Neoplasms	CONCLUSION: Our findings demonstrate that circPPFIA1s inhibit the liver metastasis of CRC via the miR5p/CDX1 and HuR/RAB36 pathways.
lncRNA target	36224570	hsa-mir-4306	Hypertrophy Of Ligamentum Flavum	CONCLUSIONS: Our study demonstrated that TCF7 inhibition could suppress HLF formation by modulating TCF7/SNAI2/miR-4306 feedback loop, which might be considered as a novel potential therapeutic target for HLF.
lncRNA target	36224570	hsa-mir-4036	Hypertrophy Of Ligamentum Flavum	Furthermore, miR-4036 negatively regulated by SNAI2 could negatively feedback regulate TCF7 expression by directly binding to TCF7 mRNA 3'-UTR, thus inhibiting the hyper-proliferation and fibrosis phenotype of HLF cells in vitro.
genetics_GWAS	36224531	hsa-mir-19b	Endothelial Barrier Dysfunction	METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock.
genetics_GWAS	36224531	hsa-mir-19b	Shock, Hemorrhagic	METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock.
other	36224455	hsa-mir-1226	Nasopharyngeal Neoplasms	Our results demonstrated the novel function of TUC338/miR3p/FGF2 axis in NPC progression, suggesting the potential diagnosis and therapeutics significance of TUC338 in NPC.
genetics_overexpression_promote	36224454	hsa-mir-671	Thyroid Cancer, Papillary	5p, and its overexpression relieved miR
lncRNA target	36224266	hsa-mir-145	Laryngeal Neoplasms	5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma.
lncRNA target	36224266	hsa-mir-144	Laryngeal Neoplasms	5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma.
genetics_overexpression_promote	36224238	hsa-mir-936	Prostatic Neoplasms	Furthermore, the overexpression of miR-936 suppresses the cell proliferation, cell cycle progression, cell migration, and invasion abilities of metastatic PCa PC-3 cells in vitro and tumor forming ability in vivo.
exosome	36224178	hsa-let-7a	Liver Injury	Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment.
exosome	36224178	hsa-let-7a	Acute-On-Chronic Liver Failure	Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment.
exosome	36224027	hsa-mir-22	Melanoma	Moreover, exosomes secreted by MSCs can be loaded with miR
exosome	36224011	hsa-let-7c	Prostatic Neoplasms, Castration-Resistant	CONCLUSIONS: MSC-derived exosomes could serve as a therapeutic let-7c delivery system to target CRPC.
exosome	36223498	hsa-mir-25	Lupus Nephritis	Urinary exosomal miR
exosome	36223498	hsa-mir-195	Lupus Nephritis	CONCLUSION: We analyzed and obtained a series of differential miRNAs in LN kidney tissues and suggested that urinary exosomal miR
exosome	36223498	hsa-mir-429	Lupus Nephritis	Urinary exosomal miR
lncRNA target	36222958	hsa-mir-205	Depression	Thus, MA may ameliorate depressive behavior through CREB/BDNF pathway regulated by miR-205/Cx43 axis.
exosome	36222945	hsa-mir-655	Esophageal Squamous Cell Carcinoma	OBJECTIVE: This study clarified the function of human umbilical cord mesenchymal stem cell (hUCMSC)-derived extracellular vesicle (EV)-enclosed miR
transcription factor target	36222901	hsa-mir-199a	Colitis	plantarum supplementation also suppressed CD44 expression (1.2 fold) by up regulating the expression of miR199a (1 fold) over DSS induced colitis. Our study suggests that Lactobacillus, lignin, and their synergistic treatments have protective roles against inflammatory bowel disease through changes in inflammatory cytokines, and miR 199a expression in DSS-induced colitis.
other	36222338	hsa-mir-143	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
other	36222338	hsa-mir-133a	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
other	36222338	hsa-mir-145	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
circRNA target	36222337	hsa-mir-124	Siderosis	Both UII and ferroptosis inducer Erastin significantly promoted the expression of alpha-SMA, Collagen I and TGF-beta1 in VAFs, but circ0004372 siRNA, miR-124 mimics, SERTAD4 siRNA or Ferrostatin-1 significantly inhibited the effect of UII and Erastin on cell activation. Therefore, these results indicate that UII promotes the activation of VAFs through the circ0004372/miR-124/SERTAD4/ferroptosis pathway.
genetics_overexpression_promote	36222159	hsa-mir-1299	Carcinoma, Hepatocellular	MiR-1299 mimics, ZC3H13 overexpression or GBX2 siRNA significantly inhibited HCC cell viability, promoted apoptosis and reduced invasion; GBX2 exerted the opposite effects and could reverse the regulatory effects of miR-1299 or ZC3H13 on HCC cells.
lncRNA target	36221890	hsa-mir-367	Lung Neoplasms	3p/TFRC pathway via resibufogenin might provide novel therapeutic targets for lung cancer therapy.
lncRNA target	36221434	hsa-mir-218	Pheochromocytoma	5p and toll-like receptors (TLR4) level were examined by both quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, the potential target genes of miR
other	36221429	hsa-mir-4748	Pulmonary Disease, Chronic Obstructive	Moreover, hsa-miR-4748/CDC42/MAPK signaling pathway may contribute to the pathogenesis of COPD, providing a potential novel therapeutic strategy in COPD.
lncRNA target	36221381	hsa-mir-181c	Frontotemporal Lobar Degeneration	In FTD, SEV miRNA-181c was downregulated compared to healthy controls. SEV miRNA-181c is significantly downregulated in FTD compared to healthy controls and may mediate its effects through microglial-directed neuroinflammation and interaction with TAR DNA-binding protein 43 (TDP-43) based on pathway analysis.
circulation_biomarker_diagnosis_up	36221381	hsa-mir-21	Frontotemporal Lobar Degeneration	Using an FDR <0.2, only miRNA5p was found to have increased expression in the cerebrospinal fluid compared to plasma in a group of AD and FTD participants.
exosome	36221294	hsa-mir-214	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-217	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-423	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-133a	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
lncRNA target	36221121	hsa-mir-223	Periodontitis	CONCLUSIONS: Our study provides novel evidence that miR-223 can be induced by periodontitis and acts as a negative regulator of PDL-derived cells osteogenesis by targeting two growth factor receptors (TGFbetaR2 and FGFR2).
other	36220723	hsa-mir-2909	Breast Neoplasms	The emerging studies of miR-2909 involvement in other cancers led us to explore its role as molecular mechanistic marker in breast cancer. CONCLUSION: The results suggest that miR-2909 forms strong thermodynamically stable molecular hybridized complexes with MRE11 and RAD50 mRNAs which further strongly interacts with argonaute protein to show potential molecular mechanistic role in breast cancer.
genetics_GWAS	36219718	hsa-mir-340	Stomach Neoplasms	PRACTICAL APPLICATIONS: Gastric cancer is the third leading cause of cancer death, and genetic and epigenetic factors, including miR-340, are involved in its pathogenesis.
circulation_biomarker_diagnosis_up	36219614	hsa-mir-221	Postoperative Cognitive Complications	Our results indicate that the plasma postoperative microRNA
circulation_biomarker_diagnosis_ns	36219565	hsa-mir-21	Lung Neoplasms	We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA5p biomarker related to lung cancer.
circulation_biomarker_diagnosis_up	36219542	hsa-mir-23b	Pancreatitis, Chronic	However, the expression of plasma glutathione peroxidase (GPx3) in early-onset ICP patients was markedly lower than that in late-onset ICP patients, although the level of hsa-miR-323b-5p was lower in late-onset patients compared to the early-onset ICP group. CONCLUSIONS: The up-regulated hsa-miR-323b-5p might play a crucial role in the early-onset mechanisms of ICP by diminishing the antioxidant activity through the down-regulation of GPx3.
epigenetics	36219533	hsa-mir-106b	Osteoporosis	CONCLUSION: Hsa-miRNA-106b-5p regulates bone formation and the pathogenesis of osteoporosis by controlling TCF4, and methylation modification of TCF4 can also affect the pathogenesis of osteoporosis.
genetics_overexpression_promote	36219369	hsa-mir-485	Adenocarcinoma of Lung	5p overexpression in LUAD cells reduced their malignant behaviors, suppressed PI3K and Akt phosphorylation, and facilitated apoptosis.
target gene	36219357	hsa-mir-326	Colorectal Neoplasms	upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells.
lncRNA target	36219356	hsa-mir-491	Squamous Cell Carcinoma of Head and Neck	In summary, we draw a conclusion that circMAT2B could modulate the processes of cell proliferation, migration, invasion, and glutaminolysis of HNSCC cells partly via the miR5p/ASCT2 axis by a molecular mechanism of competing endogenous RNA (ceRNA), implying an underlying circRNA-targeted therapy for HNSCC treatment.
genetics_knock down_promote	36219353	hsa-mir-92b	Colonic Neoplasms	We detected the expression of FEZF1-AS1, miR-92b-3p, and ZIC5 via quantitative reverse transcription-PCR, transfected colon cancer cell RKO with lentivirus and conducted FEZF1-AS1 knockdown, and performed cancer-related functional assays.
genetics_GWAS	36219319	hsa-mir-429	Glioblastoma	CONCLUSIONS: Altogether, miR-429 seems to be an efficient suppressor of the ERBB genetic signaling pathway and a potential therapeutic for GBM.
transcription factor target	36217923	hsa-mir-23b	Schizophrenia	We observed significant enrichment of MBSVs in schizophrenia, depression, bipolar disorder, and anorexia nervosa, particularly in genes targeted by several miRNA families, including miR
other	36217395	hsa-mir-221	Prostatic Neoplasms	CONCLUSIONS: TOPIIA, Ki-67 and miR-221 may not predict BCR, CR or PcD in high-risk PCa patients who underwent RP at a medium-term follow-up.
circulation_biomarker_diagnosis_ns	36217380	hsa-let-7f	Pulmonary Fibrosis	Of these, let-7f-5p showed reproducibly lower level in the blood and lung of the BIPF model rat, and the expression levels of PI3K/AKT/COX2 signaling pathway genes (PIK3CA, PDK1, Akt1, IKBKA, NF-kappaB1 and COX2) were increased in the lung of BIPF model rats, suggesting that there is a potential correlation between BIPF and the PI3K/AKT/COX2 signaling pathway.
other	36217202	hsa-mir-130b	Neoplasms, Multiple Primary	MiR-130b-3p levels were significantly upregulated and positively correlated with mTORC1 signaling in multiple cancers.
lncRNA target	36217202	hsa-mir-130b	Squamous Cell Carcinoma of Head and Neck	MiR-130b-3p inhibition attenuated tumor angiogenesis and growth in an HNSCC PDX model.
circulation_biomarker_prognosis_ns	36217165	hsa-mir-519a	Stomach Neoplasms	RESULTS: The expression level of miR-519a-3p in serum exosomes was significantly higher in GC-LM patients than in patients without LM, and high expression of exo-miR-519a-3p indicates a worse prognosis.
other	36216908	hsa-mir-193a	Obesity	The most significant association among the overlapping miRNAs was with miR-193a-5p, which was shown to be associated with type 2 diabetes and hepatic steatosis in the Rotterdam Study.
other	36216575	hsa-mir-17	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	The work uncovered a critical role of the c-MYC-miR92-BIM axis in the growth and survival of CML cells.
circulation_biomarker_diagnosis_ns	36216309	hsa-mir-33a	Carcinoma, Hepatocellular	Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention.
circulation_biomarker_diagnosis_ns	36216309	hsa-mir-122	Carcinoma, Hepatocellular	Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention.
exosome	36216243	hsa-mir-361	Diabetes Mellitus	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
exosome	36216243	hsa-mir-361	Diabetic Angiopathies	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
exosome	36216243	hsa-mir-361	Obesity	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
circulation_biomarker_diagnosis_ns	36216207	hsa-mir-545	Pneumonia	3p), and tumor necrosis factor receptor-associated factor 1 (TRAF1) in neonatal pneumonia serums and LPS-treated 16HBE cells.
genetics_knock down_promote	36216119	hsa-mir-513a	Esophageal Squamous Cell Carcinoma	miR-513a-3p was verified as a specific target of BBOX1-AS1 in ESCC, whereas knockdown of miR-513a-3p reversed the suppressive function of BBOX1-AS1 silencing in TE-1 cells.
lncRNA target	36216078	hsa-mir-222	Aortic Dissection	3p alleviated the symptom of AD in vivo by targeting STAT3, and inhibited stress fiber formation, abnormal migration, proliferation and apoptosis of HVSMCs induced by PDGF-BB by regulating the expression of alpha-SMA, SM22alpha, MMP2, MMP9 and p-Smad2.
transcription factor target	36215851	hsa-mir-484	Dengue	CONCLUSION: The miRNAs identified by sequencing, especially miR-484 may be the potential therapeutic targets for liver involvement in dengue patients which involves the regulation of vascular permeability and expression of inflammatory cytokines.
genetics_overexpression_suppress	36215729	hsa-mir-6838	Liver Neoplasms	6p was down-regulated in HCC tumors and overexpression of miR
genetics_overexpression_promote	36215729	hsa-mir-6838	Carcinoma, Hepatocellular	5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor.
genetics_overexpression_promote	36215729	hsa-mir-6838	Hepatitis B, Chronic	Overexpression of miR5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor.
lncRNA target	36215225	hsa-let-7f	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs were significantly differentially expressed between PRRSV-infected and mock-infected PAMs from 4 pig breeds. The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7d	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7d	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7f	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
genetics_knock down_promote	36214997	hsa-mir-23b	Stomach Neoplasms	Loss of SNHG17 reduced the resistance of DDP-resistant GC cells to DDP, which was achieved through miR-23b-3p-dependent Notch2 inhibition.
circulation_biomarker_diagnosis_up	36214846	hsa-mir-451a	Myocardial Infarction, Acute	MHR and miR-451a expression were markedly elevated in plasma samples of AMI patients compared with the UAP and HC groups, but the expressions of miR
circulation_biomarker_diagnosis_ns	36214846	hsa-mir-21	Myocardial Infarction, Acute	Circulating miR
circulation_biomarker_diagnosis_up	36214846	hsa-mir-486	Myocardial Infarction, Acute	The results showed that circulating miR
other	36214767	hsa-mir-145	Carcinoma, Hepatocellular	5p or RGS3 furtherly indicated UBE2MP1 as an upstream regulator of the axis in promoting HCC cell growth and maintenance.
other	36214765	hsa-mir-143	Coronary Artery Disease	In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively).
other	36214765	hsa-mir-143	Heart Valve Diseases	In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively).
other	36214718	hsa-mir-20a	Ischemic Stroke	A rat middle cerebral artery occlusionreperfusion (MCAO/R) model was established to investigate the role of the HIF1alpha/miR20a5p/KIF5A axis in ischaemic stroke in vivo.
other	36214716	hsa-mir-92a	Hirschsprung Disease	Herein, elevated expression of miR92a and reduced expression of KLF4 were found in HSCR tissues, and their expression patterns were negatively correlated.
lncRNA target	36214714	hsa-mir-642a	Glioblastoma	This study was designed to explore the function of lncRNA MAFGAS1/miR642a5p/Notch1 in glioblastoma (GBM) cells under radiation. MAFGAS1 reduces the radiosensitivity of GBM cells via miR642a5p/Notch1 axis.
lncRNA target	36214709	hsa-mir-206	Alzheimer Disease	The ADassociated network was constructed, including 2 lncRNAs (A2MAS1 and ZNF571AS1), 1 miRNA (hsamiR206), 2 mRNAs (NOTCH3 and JAG1), and 2 pathways (notch signaling pathway and endocrine resistance). A2MAS1, ZNF571AS1, hsamiR206, NOTCH3 and JAG1 may be involved in the mechanisms of AD through notch signaling pathway and endocrine resistance.
other	36214592	hsa-mir-223	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
other	36214592	hsa-mir-484	Acute Coronary Syndrome	RESULTS: The miR-484 expression was significantly upregulated in the ACS subjects (P = .0097). CONCLUSION: The results of this study indicate that the upregulated expression of miR-484 in ACS patients might be used as a diagnostic biomarker in ACS.
other	36214592	hsa-mir-126	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
other	36214592	hsa-mir-130a	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
circulation_biomarker_diagnosis_up	36213989	hsa-mir-942	Coronary Artery Disease	RESULTS: Circ_HECW2 and TLR4 expression levels were up-regulated and miR5p expression was decreased in the serum of CAD patients and oxidized low-density lipoprotein (ox-LDL)-induced hCMECs.
circRNA target	36213989	hsa-mir-942	Cardiovascular Diseases	CONCLUSION: Circ_HECW2 could regulate ox-LDL-induced cardiovascular endothelial cell dysfunction through targeting miR5p/TLR4 axis.
lncRNA target	36213586	hsa-mir-429	Nasopharyngeal Carcinoma	CONCLUSIONS: High expression of MSC-AS1 exerted a carcinogenic effect on NPC cell growth and metastasis by inhibiting miR-429 and activating the JAK1/STAT3 pathway.
genetics_GWAS	36213264	hsa-mir-143	Diabetes Mellitus, Type 2	A functional polymorphism of microRNA-143 is associated with the risk of type 2 OBJECTIVE: To explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-101	Diabetes Mellitus	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-181c	Stroke	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-181c	Diabetes Mellitus	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-101	Stroke	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
target gene	36212971	hsa-mir-28	Stomach Neoplasms	miR-28-5p's Targeting of GAGE12I Inhibits Proliferation, Migration, and Invasion of Gastric Cancer in Vitro.
genetics_overexpression_promote	36212964	hsa-mir-641	Endometrial Neoplasms	Overexpression of AP1G1 neutralized the roles of miR-641 mimic on the viability, proliferation, apoptosis, and migration of HEC-1A and HECCL-1 cells.
lncRNA target	36212960	hsa-let-7a	Atrial Fibrillation	We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF.
lncRNA target	36212960	hsa-mir-125a	Atrial Fibrillation	We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF.
target gene	36212408	hsa-mir-101	Breast Neoplasms	LncRNA SNHG6 sponges miR-101 and induces tamoxifen resistance in breast cancer cells through induction of EMT.
other	36212369	hsa-mir-96	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-159b	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-529b	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-19	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212136	hsa-mir-155	Endometriosis	5p-HIF1A, which may be closely related to OE development.
other	36212136	hsa-mir-34a	Endometriosis	5p-HIF1A, which may be closely related to OE development.
other	36212136	hsa-mir-93	Endometriosis	5p-HIF1A, which may be closely related to OE development.
genetics_GWAS	36212130	hsa-mir-101	Carcinoma, Hepatocellular	Our study is the first to demonstrate that besides genetic alteration and DNA methylation, AC145207.5/LINC01748-miR
transcription factor target	36211818	hsa-mir-28	Intervertebral Disc Degeneration	5p targets WWP2 to regulate nucleus pulposus cells apoptosis and then participates in the development of IDD.
other	36211602	hsa-mir-155	Asthma	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
other	36211602	hsa-mir-155	Hypersensitivity, Immediate	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
other	36211602	hsa-mir-155	Dermatitis, Atopic	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
circulation_biomarker_diagnosis_up	36211468	hsa-mir-26a	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
circulation_biomarker_diagnosis_up	36211468	hsa-mir-199a	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
circulation_biomarker_diagnosis_up	36211468	hsa-mir-29c	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
lncRNA target	36211460	hsa-mir-19b	Infertility, Male	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19a	Oligospermia	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19b	Oligospermia	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19a	Infertility, Male	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
circRNA target	36210730	hsa-mir-370	Tuberculosis	3p inhibition in TB progression.
lncRNA target	36210713	hsa-mir-125b	Ovarian Neoplasms	[MiR-125b-5 suppresses ovarian cancer cell migration and invasion by targeted OBJECTIVE: To investigate whether miR-125b-5p regulates biological behaviors of ovarian cancer cells by targeted regulation of CD147 expression.
genetics_knock down_suppress	36210706	hsa-let-7g	Urinary Bladder Neoplasms	Knocking down HMGB2 could partially reverse the effect of let-7g-3p knockdown on the biological behaviors of the bladder cancer cells.
transcription factor target	36210463	hsa-mir-124	Colorectal Neoplasms	5p through YAP1 nuclear translocation.
transcription factor target	36210463	hsa-mir-188	Colorectal Neoplasms	5p through YAP1 nuclear translocation.
transcription factor target	36210420	hsa-mir-210	Melanoma	The results of our study showed that miR-210/ISCU/ROS axis can serve as a novel therapeutic target in melanoma.
transcription factor target	36209087	hsa-mir-133a	Polycystic Ovary Syndrome	CONCLUSION: MiR-133a-3p promotes ovary IR on GCs of obese PCOS patients via inhibiting PI3K/AKT signaling pathway.
transcription factor target	36209049	hsa-mir-92a-2	Diabetic Cardiomyopathies	CONCLUSIONS: miR-92a5p plays an important role in cardiac oxidative stress, and may serve as a therapeutic target in DCM.
genetics_overexpression_promote	36209036	hsa-mir-539	Wilms Tumor	Overexpression of HOXB2 partially restored the inhibitory effects of miR
other	36208811	hsa-mir-4638	Breast Neoplasms	Overall, this study highlights the possibility of utilizing miR3p as a therapeutic molecule to curb skeletal metastasis of breast cancer cells.
other	36208715	hsa-mir-140	Osteoarthritis	Finally, upregulation of miR-140 in 2D chondrocytes resulted in significant upregulation of WWP2 and WDR1.
lncRNA target	36208372	hsa-mir-433	Colorectal Neoplasms	After analysis, it was found that circ_0001535 acted as a competing endogenous RNA (ceRNA) to inhibit miR
circulation_biomarker_prognosis_up	36208254	hsa-let-7b	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
circulation_biomarker_prognosis_ns	36208254	hsa-mir-146a	Multiple Myeloma	OBJECTIVE: To investigate the expression level and prognostic value of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes in patients with multiple myeloma (MM).
circulation_biomarker_prognosis_up	36208254	hsa-mir-21	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
circulation_biomarker_prognosis_up	36208254	hsa-mir-18a	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
genetics_knock down_promote	36208253	hsa-mir-21	Multiple Myeloma	KLF5 plasmid with 3'UTR knockout was synthesized and cotransfected into RPMI-8226 cells with hsa-miR-21 mimics, and the proliferation of MM cells was detected by CCK-8 and cell cloning assay.
genetics_overexpression_suppress	36208244	hsa-mir-532	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: Overexpression of miR
lncRNA target	36208243	hsa-mir-126	Lymphoma, Large B-Cell, Diffuse	The DLBCL cell line SU-DHL-4 was transfected with miR-126 inhibitor and its negative control (NC inhibitor) or miR-126 mimics and its negative control (NC mimics).
genetics_overexpression_promote	36208229	hsa-mir-196b	Leukemia, Myeloid, Acute	CONCLUSION: Overexpression of lncRNA XIST can inhibit the proliferation of acute myeloid leukemia cells KG1a and promote apoptosis by down-regulating the expression of miR-196b.
circulation_biomarker_diagnosis_ns	36207607	hsa-mir-20b	 Lymph  Node Metastasis	CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients.
circulation_biomarker_diagnosis_ns	36207607	hsa-mir-20b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients.
lncRNA target	36207305	hsa-mir-499a	Bipolar Disorder	Our results suggest that MIR499A dysregulation might contribute to BD development.
lncRNA target	36206975	hsa-mir-150	Bone Diseases	5p inhibition and hydroxyapatite/tricalcium phosphate ceramic powders enhanced bone regeneration.
exosome	36206599	hsa-mir-145	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Collectively, exosomal miRderived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1.
circulation_biomarker_diagnosis_up	36206272	hsa-mir-19b	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-21	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-222	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-103a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-376a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-26a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-23a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_prognosis_ns	36206229	hsa-mir-125b	Inflammatory Bowel Diseases	CONCLUSION: Serum LncRNA THRIL and MiR-125b could be used as potential biomarkers for diagnosis and prognosis of ulcerative colitis and Crohn&#x27;s disease.
genetics_knock down_suppress	36206143	hsa-mir-377	Chordoma	3p overexpression-mediated antitumor effects in chordoma cells were largely attenuated by SMAD3 overexpression.
genetics_overexpression_promote	36206112	hsa-mir-497	Esophageal Squamous Cell Carcinoma	5p overexpression-mediated influences in ESCC cells were largely reversed by the addition of SLC1A5 expressing plasmid.
exosome	36206102	hsa-mir-449a	Stomach Neoplasms	Exosomal circ_0063526 facilitated CDDP resistance in gastric cancer via regulating the miR-449a/SHMT2 axis.
other	36206098	hsa-mir-197	Pituitary Neoplasms	Our findings suggest a regulatory network of lncRNA MYMLR/miR3p/CBR1, which benefits the understanding of PA development and provides a promising lncRNA-direct therapeutic strategy against PA.
genetics_overexpression_suppress	36206095	hsa-mir-512	Carcinoma, Non-Small-Cell Lung	5p could be sponged by circ_0010235, and its overexpression had an inhibition effect on the PTX resistance of NSCLC cells.
genetics_knock down_suppress	36204881	hsa-mir-197	Gastrointestinal Stromal Tumors	3p reversed the effect of circ-CCS knockdown on apoptosis and autophagy in GIST cells.
other	36204642	hsa-mir-23b	Carcinoma, Hepatocellular	Based on their RNA-RNA interaction and expression analysis, four DElncRNAs (TRHDE-AS1, DLX6-AS1, SNHG14, HOXA11-AS), four DEmiRNAs (miR-23b, miR-320a, miR-589, miR-126) and five DEmRNAs (PKIA, PCDHA2, SHCBP1, PRSS16, KIF18A) in HCC tumor vs normal groups were subjected to the hub regulatory networks analysis and further prognostic value analysis. Importantly, the TRHDE-AS1/miR-23b/PKIA ceRNA network was associated with HCC prognosis.
other	36204577	hsa-mir-222	Cardiomyopathies	CONCLUSION: In summary, we propose that THBS1 may be a key IRHG, and can serve as a biomarker for the diagnosis of SCM; in addition, the immune-related regulatory network miR3p/THBS1 may be involved in the regulation of the pathogenesis of SCM and may serve as a promising candidate for SCM therapy.
other	36204312	hsa-mir-21	Tuberculosis	A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation.
other	36204312	hsa-mir-600	Tuberculosis	A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation.
target gene	36204179	hsa-mir-522	Stomach Neoplasms	MiR-522-3p Targets Transcription Factor 4 to Overcome Cisplatin Resistance of Gastric Cells.
lncRNA target	36204112	hsa-mir-129-1	Neurotoxicity Syndromes	Collectively, we found a novel circ_0015891/miR1-3p axis that may be a promising therapeutic target for METH-induced dopaminergic neurotoxicity.
other	36203804	hsa-mir-145	Dementia, Vascular	5p), six TFs (Csrnp1, Klf4, Nfatc4, Rxrg, Foxj2, and Klf5), and five mRNAs (Serpine1, Plec, Nedd4l, Trip12, and Tpm1) were significantly changed in rats with VaD, in line with the outcome of RNA sequencing.
circRNA target	36203795	hsa-mir-7001	Postoperative Cognitive Complications	5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD.
circRNA target	36203795	hsa-mir-490	Postoperative Cognitive Complications	5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD.
lncRNA target	36203618	hsa-mir-150	Osteoarthritis	5p were lower in human OA synovial tissue compared with non-OA specimens.
other	36203524	hsa-mir-421	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-339	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-18a	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-483	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-133a	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-584	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-122	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-106b	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
genetics_knock down_suppress	36203485	hsa-mir-34c	Stomach Neoplasms	This study aimed to investigate the expression, biological function, and downstream mechanism of miR-34c-5p in GC, provide new targets for gastric cancer diagnosis and treatment. miR-34c-5p overexpression inhibited migration, invasion, and colony formation of gastric cancer cells, the related protein E-cadherin expression was significantly increased and N-cadherin, vimentin, and PCNA expression were significantly decreased, while miR-34c-5p knockdown exerted the opposite effects.
lncRNA target	36203462	hsa-mir-182	Carcinoma, Hepatocellular	Notably, while the expression of most miRs deregulated in preneoplastic lesions was not altered in HCC or in hepatoma cells, miR-182, a miR known to target Dio1 and mitochondrial complexes, was down-deregulated by T3 treatment at all stages of hepatocarcinogenesis and in hepatocarcinoma cell lines. In support to the possible critical role of miR-182 in hepatocarcinogenesis, exogenous expression of this miR significantly impaired the inhibitory effect of T3 on the clonogenic growth capacity of human HCC cells.
exosome	36203260	hsa-mir-375	Hepatitis C	miR-375, secreted through exosomes derived from HCV-infected cells, could also be transferred to naive Huh7.5 cells, resulting in an increase in cell proliferation and migration in the recipient cells.
lncRNA target	36202872	hsa-mir-186	Triple Negative Breast Neoplasms	5p regulated the cell viability rate of docetaxel-resistant breast cancer cells.
lncRNA target	36202651	hsa-mir-335	Adrenal Cortex Neoplasms	CONCLUSION: A messenger RNA-microRNA-long noncoding RNA network analysis identified the BIRC5-miR335-5p-PAX8-AS1 network as one that was associated with poor overall survival in adrenocortical carcinoma, warranting further validation as a potential therapeutic target.
other	36202613	hsa-mir-16	Distal myopathy, Nonaka type	To the best of our knowledge, this is the first time that a predictive signature has been composed of genes belonging to the same mechanism (miR-16) in UM. Altogether, our results strongly suggest that UM is a miR-16 disease.
other	36202232	hsa-mir-363	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-1	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-206	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-4286	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-146a	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-196b	Melanoma	3p (>2.5-fold increase, P < 0.014).
genetics_knock down_suppress	36202224	hsa-mir-424	von Willebrand Diseases	Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro.
genetics_knock down_suppress	36202224	hsa-mir-424	Breast Neoplasms	Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro.
transcription factor target	36202203	hsa-mir-17	Necrobiotic Disorders	5p inhibitor cell model, resulting in the inactivation of NLRP3 inflammasome-dependent pyroptosis.
circulation_biomarker_diagnosis_up	36201274	hsa-mir-26b	Cardiomegaly	Thereafter, the CHF rats were injected with relative oligonucleotides and plasmids of HDAC3, miR-26b-3p and HMGA2 to detect the cardiac function, inflammatory reaction, myocardial tissue pathological changes, and cardiomyocyte apoptosis.
transcription factor target	36200697	hsa-mir-527	Acute Kidney Injury	CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1.
transcription factor target	36200697	hsa-mir-527	Sepsis	CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1.
genetics_knock down_promote	36200682	hsa-mir-421	Pancreatic Carcinoma	HIF-1alpha overexpression reversed the inhibiting effects of SIRT3 overexpression on PC progression and counteracted the inhibiting effects of miR-421 knockdown on glycolysis.
other	36200549	hsa-mir-223	Diabetes Mellitus	After inclusion of covariates, age, gender (male), New York Heart Association class and diabetes into the multivariate Cox regression model, miR-223 did not reach statistical significance (HR: 2.56, 95% CI: 0.79-8.33; p = 0.118).
genetics_knock down_suppress	36200529	hsa-mir-20b	Colorectal Neoplasms	Reducing miR-20b-3p or raising DEPDC1 levels weakened the effect of SIRT1 knockdown on L-OHP-resistant-CRC cells.
other	36200149	hsa-mir-3074	Diabetic Ischemia Complication	One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p.
other	36200149	hsa-mir-3074	Diabetes Mellitus	One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p.
genetics_overexpression_promote	36200131	hsa-mir-194	Hypertensive Retinopathy	5p upregulation restrained angiogenesis and increased tight junction protein levels in Ang II-treated HRMECs, and the effect was reversed by SOX17 overexpression.
other	36200027	hsa-mir-139	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-148	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-1305	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-376	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
circulation_biomarker_diagnosis_ns	36200021	hsa-mir-29	Hypertension	OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia.
genetics_GWAS	36200021	hsa-mir-21	Hypertension	METHOD: In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P = 0.005 and P = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P = 0.002 and P = 0.048).
circulation_biomarker_diagnosis_ns	36200021	hsa-mir-199	Hypertension	OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia.
lncRNA target	36199788	hsa-mir-31	Osteosarcoma	3p affected the occurrence and development of osteosarcoma by targeting the SOCS1/JAK2/STAT3 signaling pathway.
exosome	36199785	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	Macrophages transfected with miR-1246 inhibitor suppressed LSCC cell viability, migration, and invasion. CONCLUSION: In summary, our data implied that the exosomal, miR-1246 of LSCC, induced polarization of M2 type macrophages and promoted the progression of LSCC.
lncRNA target	36199571	hsa-mir-154	Urinary Bladder Neoplasms	Second, significantly altered miRNAs in recurrent bladder cancer were identified, with miR5p showing the highest level of editing in recurrent bladder cancer and may up-regulate the expression levels of downstream targets HS3ST3A1, AQP9, MYLK, and RAB23.
target gene	36199554	hsa-mir-7	Colorectal Neoplasms	The Transcription Factor Otc4A Stimulates the Proliferation, Invasion, and Stemness of Colorectal Cancer Cells by Inhibiting the Regulation of miR-7-5p on TLR4.
other	36199284	hsa-mir-21	Esophageal Neoplasms	However, the results are varied, and no studies on the diagnostic usefulness of miR-21 in Asian esophageal cancer (EC) patients have been published. CONCLUSION: Our findings suggest miR-21 might be the potential biomarker for detecting EC in Asian populations, with a good diagnostic value.
lncRNA target	36199080	hsa-mir-10a	Osteosarcoma	CONCLUSION: Lnc-SELPLG-2:1 is an oncogenesis activator in osteosarcoma, and its functions are performed via hsa-miR-10a-5p /BTRC cascade.
genetics_knock down_promote	36198257	hsa-mir-133b	Pneumonia, Mycoplasma	CONCLUSION: The current evidence demonstrated that circ_0088196 knockdown facilitated trophoblastic cell development by regulating the levels of miR-133b and AHNAK, suggesting that circ_0088196 promoted the PE progression via the miR-133b/AHNAK axis.
genetics_overexpression_promote	36198203	hsa-mir-20b	Uterine Cervical Neoplasms	The impacts of MEF2C-AS1 elevation on CC cell proliferative, migratory, and angiogenic capabilities were countervailed by miR-20 b-5p overexpression.
circulation_biomarker_diagnosis_ns	36198129	hsa-mir-499	Myocardial Infarction	It enables the rapid detection of an AMI-related miRNA (miR-499) at 10 aM in human serum within 30 min using the SNAzyme-catalyzed luminol-H(2)O(2) ECL reaction. This sensing strategy is then utilized for AMI diagnosis via probing endogenous miR-499 in patients' circulating blood with endogenous miR-16 as an intrinsic reference, showing a significant difference (P < 0.001) between the miR-499 levels of patients and the healthy.
lncRNA target	36197604	hsa-mir-21	Coronary Artery Disease	CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation.
lncRNA target	36197604	hsa-mir-133b	Coronary Artery Disease	CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation.
genetics_overexpression_promote	36197580	hsa-mir-377	Glioma	3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation.
circulation_biomarker_prognosis_down	36197268	hsa-mir-34a	Osteosarcoma	CONCLUSION: The expression level of serum miR-34a in patients with OS is closely related to the chemotherapy resistance, metastasis, recurrence, and survival of osteosarcoma, which can be used as one of the potential biomarkers and prognosis for the treatment of OS patients.
circulation_biomarker_diagnosis_ns	36197244	hsa-mir-21	Cardiomegaly	These findings indicate the potential crosstalk between serum miR-21 and inflammation during CHF progression, suggesting the potential of miR-21 in CHF diagnosis, severity indication, and treatment.
genetics_overexpression_suppress	36196919	hsa-mir-760	Carcinoma, Non-Small-Cell Lung	Furthermore, KIF2A overexpression neutralized miR
other	36196089	hsa-mir-22	Myopathies, Structural, Congenital	Our results identify RYR1, ATPB2B and miRNA-22 as common transcripts whose expression is decreased in muscles from congenital myopathy patients.
lncRNA target	36195937	hsa-mir-148a	Cardiomegaly	Similar results were obtained in angiotensin II-induced hypertrophy of NRCMs, in which the beneficial effects of HHP-EXO were abolished by miRNA-148a inhibition.
genetics_overexpression_promote	36195847	hsa-mir-200a	Papillomavirus Infections	RESULTS: The results demonstrated that miR-200a-3p overexpression suppressed proliferation, migration, and invasion of the HPV-negative C33A cells but promoted the growth and metastasis of HPV-positive CC cells, while YAP promoted the cell growth and metastasis not only in HPV-negative but also in the HPV-positive CC cells.
lncRNA target	36195691	hsa-mir-1192	Reperfusion Injury, Cerebral Ischemia	Overall, GAS5 silencing inhibited AQP4 through the miR-1192/STAT5A axis, thus alleviating cerebral I/R injury.
circulation_biomarker_diagnosis_ns	36195304	hsa-mir-492	Pneumonia, Mycoplasma	OBJECTIVE: This study aimed to evaluate the role of miRNA-492 in the progression of mycoplasma pneumoniae (MP) infection in pediatric patients. CONCLUSION: The present study's results suggested that miRNA-492 might play a role in the pathogenesis of mycoplasma pneumoniae pneumonia in children by regulating the secretion of immune-inflammatory factors such as IL-6 and IL-18 in the mononuclear macrophages.
transcription factor target	36195241	hsa-mir-181b	Liver Cirrhosis	Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis.
transcription factor target	36195241	hsa-mir-181b	Schistosomiasis	Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis.
other	36194985	hsa-mir-619	Osteoarthritis	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
other	36194985	hsa-mir-619	Osteoarthritis 	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
other	36194985	hsa-mir-619	Inflammation	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
lncRNA target	36194972	hsa-mir-221	Arthritis, Rheumatoid	The therapeutic effect of triptolide on miR-221 Exs was reversed by miR-221 inhibitor in both normal and RA FLS.
genetics_GWAS	36194668	hsa-mir-181a	Retinal Diseases	Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches.
genetics_GWAS	36194668	hsa-mir-181b	Retinal Diseases	Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches.
genetics_GWAS	36194484	hsa-mir-1307	Anxiety Disorders	OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population.
genetics_GWAS	36194484	hsa-mir-1307	Depression	OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population.
target gene	36193940	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells.
genetics_knock down_promote	36193788	hsa-mir-1253	Lung Neoplasms	Circ-EIF3I could sponge miR-1253, and miR-1253 inhibitor overturned the regulation of circ-EIF3I knockdown on LC cell progression.
genetics_overexpression_promote	36193608	hsa-mir-9a	Ceroid lipofuscinosis, neuronal 5	In the VILI rat model, miR-9a-5p targeted the negative regulation of CXCR4, and CXCR4 overexpression to reverse the lung-protective and anti-inflammatory effects of miR-9a-5p overexpression in VILI rats.
transcription factor target	36193608	hsa-mir-9a	Lung Injury	CONCLUSION: miR-9a-5p can hinder the activation of the MAPK/ERK signaling pathway and reduce inflammatory reactions and lung injury in VILI rats through the targeted regulation of CXCR4 expression.
lncRNA target	36193590	hsa-let-7e	Hematologic Diseases	Let-7e-5p may be a potential therapeutic target of benzene-induced hematotoxicity, provide a basis for evaluating the health hazards of long-term and low-dose benzene exposure in workers, and supply a reference for revising occupational health standards.
lncRNA target	36193508	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	CONCLUSION: We demonstrated that hsa_circ_0003176 suppressed the NSCLC progression via regulating miR
other	36193506	hsa-mir-28	Pain	5p in PA cells.
other	36193503	hsa-mir-125b	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-181a	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-139	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-29b	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-140	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-122	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
genetics_GWAS	36193501	hsa-mir-137	Bipolar Disorder	This preliminary study is aimed at investigating the effects of genetic variations in miR-137 (rs1625579A/C), TCF4 (rs1261084C/T), and CACNA1C (rs10774053A/G and rs10466907G/T) on BD susceptibility.
lncRNA target	36193326	hsa-mir-20a	Femur Head Necrosis	Moreover, we proposed a ceRNA network of lncRNAs targeting hsa-miR-320a, hsa-miR-320a, and NOD2 as a potential RNA regulatory pathway that controls disease progression in ONFH.
transcription factor target	36193307	hsa-mir-20a	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
transcription factor target	36193307	hsa-mir-636	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
transcription factor target	36193307	hsa-mir-7	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
other	36193251	hsa-mir-100	Melanoma	5p is revealed, and the present study is followed by a discussion of its molecular regulatory network, followed by novel insights into SKCM therapy.
circulation_biomarker_diagnosis_ns	36193149	hsa-mir-184	Respiratory Distress Syndrome	OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3.
circulation_biomarker_diagnosis_ns	36193149	hsa-mir-126	Respiratory Distress Syndrome	OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3.
genetics_knock down_suppress	36193129	hsa-mir-654	Colonic Neoplasms	CONCLUSION: Collectively, this study revealed that the knockdown of LINC01124 inhibited the malignant behaviors of CC via the miR
other	36193069	hsa-mir-192	Glioma	5p/ZEB2 axis.
genetics_knock down_promote	36192755	hsa-mir-1827	Carcinoma, Non-Small-Cell Lung	Also, SLC1A5 overexpression abolished the inhibition effect of miR-1827 on NSCLC cell progression.
circulation_biomarker_diagnosis_ns	36192429	hsa-mir-126	Carotid Artery Diseases	Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability.
circulation_biomarker_diagnosis_ns	36192429	hsa-mir-223	Carotid Artery Diseases	Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability.
genetics_knock down_promote	36192016	hsa-mir-1303	Carcinoma, Hepatocellular	Knockdown of miR-1303 attenuated cell proliferation, migration and invasion, and induced apoptosis in liver-cancer cells.
lncRNA target	36192016	hsa-mir-1303	Liver Neoplasms	However, the biological role of miR-1303 in the progression of liver cancer and its regulatory mechanism has not been elucidated. CONCLUSION: miR-1303 plays an important role in liver cancer, which is inhibited by TLN1 expression.
other	36191794	hsa-mir-328a	Pregnancy, Prolonged	Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage.
other	36191794	hsa-mir-328a	Sciatic Neuropathy	Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage.
circRNA target	36191606	hsa-mir-765	Fluoride Poisoning	We further showed that hsa_circ_0007478/miR-765/EFNA3 axis could also be involved in the inhibition of the lipid metabolism and foam cells formation in ox-LDL-macrophages.
lncRNA target	36191448	hsa-mir-125b	Ovarian Neoplasms	CONCLUSION: KCNQ1OT1 accelerated OC progression via miR-125b-5p/CD147 axis indicating KCNQ1OT1 serve as a novel biomarker for OC treatment.
lncRNA target	36191447	hsa-mir-648	Stomach Neoplasms	METHODS: The current study sought to evaluate the miR-648 expression in GC and any plausibility of its replacement, either with or without the combination of chemo agents to downregulate ET-1 expression through interaction with its target gene.
circulation_biomarker_diagnosis_ns	36191258	hsa-mir-210	Sleep Apnea, Obstructive	ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance.
circulation_biomarker_diagnosis_ns	36191258	hsa-mir-210	Acute Lung Injury	ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance.
genetics_overexpression_promote	36190650	hsa-mir-206	Esophageal Neoplasms	Meanwhile, overexpression of HOXA13 partially reversed the suppressive effects of miR-206 enrichment on ESCC cell malignant behaviors. CONCLUSION: In short, circ_0008726 exerted the carcinogenic effects to regulate the proliferation, invasion, angiogenesis and apoptosis of ESCC cells by targeting miR-206/HOXA13 axis.
lncRNA target	36190453	hsa-mir-375	Stomach Neoplasms	This study provides a potential target for gastric cancer progression based on the circRPPH1/miR-375/SLC7A11 regulatory axis.
circRNA target	36190397	hsa-mir-1234	Stomach Neoplasms	Furthermore, OE of hsa_circ_0006470 inhibited the tumorigenesis of GC via the regulation of the miR-1234/TP53I11 axis. In summary, the present study demonstrated that OE of hsa_circ_0006470 notably inhibited the tumorigenesis of GC by regulating the miR-1234/TP53I11 axis.
exosome	36190183	hsa-mir-221	Cerebrovascular Disorders	In conclusion, miR3p in EPC derived exosomes ameliorates OGD-induced neuronal apoptosis, which establish its potential as a new therapeutic method for patients with cerebrovascular diseases.
other	36189421	hsa-mir-143	Colorectal Neoplasms	Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells.
lncRNA target	36189147	hsa-mir-133c	Myocardial Reperfusion Injury	CONCLUSION: In sum, the identified ceRNA network which included the lncRNA Xist/miR-133c/Slc30a9 axis might contribute a better understanding to the pathogenesis and development of MI/R injury and offer a novel targeted therapy way.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-181a	Rh-Negative Hemolytic Disease, Fetus	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-125b-2	Rh-Negative Hemolytic Disease, Fetus	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-181a	Placenta Diseases	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-125b-2	Placenta Diseases	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
other	36188379	hsa-mir-379	Epilepsies, Partial	"However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence."
other	36188379	hsa-mir-154	Epilepsies, Partial	"However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence."
circulation_biomarker_diagnosis_up	36188229	hsa-mir-19b	Breast Neoplasms	Results: In the screening phase, 5 circulating miRNAs (miR-16, miR-17, miR-19b, miR-27a, and miR-106a) were identified as the most significantly upregulated miRNAs in plasma of BC patients. Conclusion: The current study developed a miR-19b-based 3-miRNA model holding potential for diagnosis of BC using blood samples.
other	36187569	hsa-mir-424	Gram-Negative Bacterial Infections	The duplex test, including miR-424 and CRP, has a diagnostic value for detecting the high risk of post-transplant gram-negative bacteremia in heart and lung transplant recipients.
epigenetics	36187230	hsa-mir-194	Ovarian Neoplasms	CONCLUSION: Our work demonstrates that lncRNA DARS-AS1 promotes OC progression by modulating TSPAN1 and ITGA2 hypomethylation by binding with miR
genetics_knock down_promote	36187163	hsa-mir-155	Pancreatitis	Multivariate analysis showed that the BISAP score, BUN, Leukocytes, age and CRP were independent risk factors for progression to SAP among AP patients after adjusting for hypertension, ICU admission, hospital stay and Fibrinogen, while miR-155 was a protective factor.
other	36187128	hsa-mir-503	Diabetes Mellitus, Type 2	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-503	Carotid Artery Diseases	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-4435-1	Carotid Artery Diseases	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-4435-1	Diabetes Mellitus, Type 2	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
transcription factor target	36186733	hsa-mir-642a	Inflammation	These results suggest that miR-642a-5p can inhibit the inflammation by suppressing the TLR4 signalling pathway in THP-1 cells.
other	36186733	hsa-mir-642a	Inflammatory Bowel Disease 11	Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response.
circulation_biomarker_diagnosis_down	36186733	hsa-mir-642a	Glucocorticoid Receptor Deficiency	Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response. We found that after treatment with miR-642a-5p mimics and DEX, the expression levels of glucocorticoid receptor (GR) in the nucleus and NF-kappaB p65 and p50 in the cytoplasm were increased (P < 0.05).
circulation_biomarker_prognosis_ns	36186528	hsa-mir-34a	Respiratory Distress Syndrome, Newborn	CONCLUSION: Serum miR-34a, Ang-1, and NCIS are closely related to the severity and prognosis of neonatal RDS.
other	36186470	hsa-mir-378f	Diabetic Retinopathy	3p and -665 can be used as powerful markers for DR diagnosis, and the ceRNA network: lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 may represent an important regulatory role in DR progression.
genetics_knock down_promote	36186461	hsa-mir-466	Non-alcoholic Fatty Liver Disease	These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway.
genetics_knock down_promote	36186461	hsa-mir-669c	Non-alcoholic Fatty Liver Disease	These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway.
epigenetics	36186442	hsa-mir-21	Carcinoma, Renal Cell	High PRKCE methylation levels and hsa-miR5p may contribute to PRKCE low expression in KIRC.
other	36186432	hsa-mir-17	Peripheral Arterial Occlusive Disease 1	Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD.
other	36186432	hsa-mir-20b	Peripheral Arterial Occlusive Disease 1	Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD.
genetics_knock down_promote	36186122	hsa-mir-124	Cognition Disorders	Here we reported age-related loss of miR-124 in human and rat brains. Our work suggested that age-related cognitive decline, at least in part, was associated with miR-124 deficiency and subsequently upregulated RyR3 expression in inducing neuronal death.
exosome	36185995	hsa-mir-10b	Colorectal Neoplasms	Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database.
exosome	36185995	hsa-mir-150	Colorectal Neoplasms	Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database.
other	36185765	hsa-mir-363	Ischemic Stroke	This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1).
other	36185765	hsa-mir-4500	Ischemic Stroke	This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1).
other	36185590	hsa-mir-133a	Myocardial Infarction	Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination.
other	36185590	hsa-mir-1	Myocardial Infarction	Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination.
other	36185502	hsa-mir-384	Thyroid Neoplasms	Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384.
circulation_biomarker_diagnosis_down	36185088	hsa-mir-130a	psoriasis 1	Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis.
circulation_biomarker_prognosis_ns	36185088	hsa-mir-130a	Abnormalities, Multiple	Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis.
lncRNA target	36184817	hsa-mir-140	Memory Disorders	5p inhibition enhanced Pin1 and ADAM10 mRNA expressions but has little effect on Pin1 protein level.
transcription factor target	36184552	hsa-mir-32	Atherosclerosis	5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation.
transcription factor target	36184552	hsa-mir-32	Inflammation	5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation.
lncRNA target	36184551	hsa-mir-6870	Coronary Artery Disease	3p regulates human EAT inflammation by targeting the Tollip-mediated JNK and NF-kappaB signaling pathways.
lncRNA target	36184541	hsa-mir-466	Myocardial Reperfusion Injury	Thus, LincRNA-p21 positively regulated the expression of Nr4a2, through sponging miR-466i-5p, promoting cardiomyocyte apoptosis in myocardial I/R injury. The current study revealed a novel LincRNA-p21/miR-466i-5p/Nr4a2 pathway for myocardial I/R injury, indicating that LincRNA-p21 may serve as a potential target for future therapy.
lncRNA target	36184488	hsa-mir-214	Squamous Cell Carcinoma of Head and Neck	CircFNDC3B silencing restrains the tumorigenesis of oesophageal squamous cell carcinoma through miR3p/CDC25A axis, which opens a new window to the development of novel therapeutic strategy for ESCC patients.
transcription factor target	36184123	hsa-mir-520d	Osteosarcoma	Our results suggests that RPS inhibits the VM formation and metastasis of OS by modulating the miR-520d-3p/MIG-7 signaling axis.
transcription factor target	36183924	hsa-mir-203	Pancreatic Carcinoma	In this study we aimed to explore interaction between downregulated miR-203 and its upregulated target DUSP5 in PC. CONCLUSIONS: These findings suggest that miR-203 restrains proliferation and migration of PC cells by regulating oncogenic activity of DUSP5 in PC, thereby could be novel candidate biomarkers for PC diagnosis and treatment.
transcription factor target	36183365	hsa-mir-20	Adenocarcinoma of Lung	Bioinformatics analyses suggested that SIGLEC17P might exert antioncogenic effects in LUAD through the mir
genetics_knock down_suppress	36183123	hsa-mir-1297	Glioma	More importantly, under TMZ treatment, inhibition of miR-1297 attenuated TMZ treatment on glioma cells; ADM knockdown partially attenuated the effects of miR-1297 inhibition on TMZ-treated glioma cells.
genetics_overexpression_promote	36183046	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1.
other	36182923	hsa-mir-222	Polycystic Ovary Syndrome	3p assisted PCOS diagnosis and predicted increased risks of diabetic and cardiovascular complications.
transcription factor target	36181964	hsa-mir-365b	Alzheimer Disease	Based on the evidence, we finally identified hsa-miR-365b-5p as a key target in Alzheimer's disease. CONCLUSIONS: Hsa-miR-365b-5p act as a key target in Alzheimer's disease.
circulation_biomarker_diagnosis_up	36181627	hsa-let-7c	Moyamoya Disease	Our results demonstrated that the TLR7 and microRNA Let-7c expression are upregulated in VSMCs and the plasma of MMD patients, respectively.
other	36181617	hsa-mir-34a	Diabetes Mellitus, Type 2	After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity.
other	36181617	hsa-mir-143	Diabetes Mellitus, Type 2	After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity.
genetics_knock down_promote	36181561	hsa-mir-634	Squamous Cell Carcinoma of Head and Neck	MiR-634 targeted MAP2K4 and negatively regulated MAP2K4 expression, and overexpression of miR-634 inhibited TSCC cell proliferation, migration, and invasion, while co-overexpression of MAP2K4 was able to reverse the effects of miR-634 in TSCC cells.
lncRNA target	36181383	hsa-mir-137	Inflammation	CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment.
lncRNA target	36181383	hsa-mir-137	Norrie disease	In addition, miR-137 expression was negatively correlated with circHOMER1 and SOX6 expression in DN patients. CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment.
lncRNA target	36181281	hsa-mir-665	Colorectal Neoplasms	We further demonsatred that miR-665/E2F3 axis mediated the functional role of hsa_circ_0081069 in regulating the malignant phenotype of CRC cells. Targeting hsa_circ_0081069 and miR-665/E2F3 axis could serve as potential therapeutic strategies for CRC treatment.
genetics_overexpression_promote	36180981	hsa-mir-514b	Carcinoma, Non-Small-Cell Lung	Furthermore, overexpression of miR-514b-5p promoted NSCLC cell growth and suppressed apoptosis by inducing the activation of the phosphatidylinositol
other	36180946	hsa-mir-556	Acute Kidney Injury	Urine miR3p had the potential to improve the prediction of renal recovery from severe AKI.
circRNA target	36180890	hsa-mir-409	Breast Neoplasms	CONCLUSION: CircTRIM28 facilitated the BC via miR
lncRNA target	36180862	hsa-mir-107	Acute Lung Injury	This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107.
lncRNA target	36180862	hsa-mir-107	Sepsis	This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107.
other	36180575	hsa-mir-93	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-20a	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-17	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-195	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-19a	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-144	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-142	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-16	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180561	hsa-mir-26b	Obesity	Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction.
circulation_biomarker_diagnosis_up	36180561	hsa-mir-155	Obesity	No changes were observed in the group of obese female dogs with normal serum biochemical profile and in relation to miR-155 expression.
other	36180561	hsa-mir-132	Obesity	Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction.
other	36180558	hsa-mir-28	Carcinoma, Renal Cell	The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively.
other	36180558	hsa-mir-125a	Carcinoma, Renal Cell	The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively.
circulation_biomarker_diagnosis_down	36180486	hsa-mir-21	Glioblastoma	We suggest that the increased exosomal miR-21 from Toxoplasma-infected BV2 microglial cells may play an important role as a cell growth promotor of U87 glioma cells through a down-regulation of anti-tumorigenic genes.
other	36180298	hsa-mir-133a-1	Diabetes Mellitus, Type 2	rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM.
other	36180298	hsa-let-7f	Diabetes Mellitus, Type 2	rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM.
transcription factor target	36180007	hsa-mir-27a	Thyroid Cancer, Papillary	Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2.
transcription factor target	36180007	hsa-mir-27a	Ischemic Stroke	Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2.
lncRNA target	36179941	hsa-mir-103a	Graves Ophthalmopathy	miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels.
lncRNA target	36179941	hsa-mir-103a	Diabetic Nephropathies	miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels.
circulation_biomarker_diagnosis_ns	36178486	hsa-mir-92a	Sepsis	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circulation_biomarker_diagnosis_down	36178486	hsa-mir-92a	Polycythemia	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circulation_biomarker_diagnosis_ns	36178486	hsa-mir-92a	beta-Thalassemia	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circRNA target	36178207	hsa-mir-122	Uterine Cervical Neoplasms	5p competition and thus promotes the development of CC, providing a novel targeted therapy for CC.
lncRNA target	36178080	hsa-mir-144	Osteoarthritis	CONCLUSION: LncRNA TM1-3P improved inflammation and damage of knee joints in OA rats through miR3p/ONECUT2 axis, providing a new theoretical basis for gene therapy of OA.
other	36177926	hsa-mir-494	Cystic Fibrosis	OBJECTIVE: To observe the effects of Xiaoqinglong Decoction and Qingqi Huatan Pills on interleukin-1beta (IL-1beta)-induced mucushypersecretion model of human airway epithelial H292 cellsand related molecules of nuclear factor-kappaB/microRNA-494(NF-kappaB/miR-494) signaling pathway, and to explore the mechanism of the two medicines in improving pathological airway mucus.
transcription factor target	36177783	hsa-mir-204	Brain Injuries	These results suggest that down-regulation of miR5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting VCAM1.
other	36177782	hsa-mir-16	Premature Ejaculation	We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls.
other	36177588	hsa-mir-203a	Vascular Diseases	5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01).
other	36177588	hsa-mir-29	Vascular Diseases	5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01).
circulation_biomarker_diagnosis_up	36177494	hsa-mir-125b	Lupus Erythematosus, Systemic	5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls.
circulation_biomarker_diagnosis_up	36177494	hsa-mir-9	Lupus Erythematosus, Systemic	5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls.
transcription factor target	36177008	hsa-mir-27b	Inflammatory Bowel Diseases	Moreover, the marked upregulation of six miR-27b target genes (IFI16, GCA, CYP1B1, RUNX1, MEF2C and MMP13) in the inflamed colon tissues is a possible direct consequence of the lack of repression due to the downregulated miRNA-27b expression.
lncRNA target	36176750	hsa-mir-186	Mesothelioma, Malignant	Conclusion: We unraveled a novel mechanism of action of butein, which attenuated the pro-tumorigenic features of MPM at least through a miR
other	36176029	hsa-mir-200b	Colitis	Notably, MVs from normal feces could effectively reverse the composition of the intestinal microbiota, restore the intestinal barrier and rescue colitis, and BMVs from colitis would also have similar effects after miR-200b-3p treatment.
genetics_overexpression_promote	36175984	hsa-mir-146a	Spinal Cord Injuries	miR-146a-5p was overexpressed in exosomes, and then, miR-146a-5p-modified exosomes were used to investigate the ability of exosomes to reduce neurotoxic astrocyte effects, preserve neurons and promote neurological function recovery in rats with SCI.
lncRNA target	36175893	hsa-mir-4741	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
lncRNA target	36175893	hsa-mir-508	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
lncRNA target	36175893	hsa-mir-3158	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
other	36175844	hsa-mir-181a	Chronic Disease	CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific.
circulation_biomarker_diagnosis_up	36175844	hsa-mir-181a	Aicardi-Goutieres syndrome 5	This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97. CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific.
circulation_biomarker_diagnosis_up	36175844	hsa-mir-181a	Multiple Chronic Conditions	This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97.
lncRNA target	36175700	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	The results confirmed the anti-tumor impact of berberine on CLL cells through reducing CD69, Ki67, and miR-155 expression and increasing cleaved PARP1 may be considered as an option for future clinical studies.
lncRNA target	36175341	hsa-mir-339	Pain, Postoperative	So, the authors hypothesized that miR5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP.
transcription factor target	36174767	hsa-mir-130a	Osteoporosis	In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRalpha/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats.
other	36174738	hsa-mir-200b	Encephalomyelitis, Eastern Equine	Furthermore, the expression of miR-200b-3p was increased, while that of ERG and PTHrP was markedly reduced in PEE fetal cartilage.
other	36174709	hsa-mir-148a	Osteoporosis	Moreover, histone acetylation of the WNT-1 gene and miR-148a-3p interference proved to play a role in the regulation of the WNT-signalling pathway during OP progression and treatment.
lncRNA target	36174668	hsa-mir-29a	Parkinson Disease	In conclusion, this research provides novel insight into a neuroprotective pathway of miR-29a and could thus serve as a possible therapeutic target for improving the treatment of PD.
lncRNA target	36173586	hsa-mir-101	Abortion, Habitual	3p/OTUD3 may be potential targets for the prevention of unexplained RSA.
other	36173547	hsa-mir-125a	Cataract, Age-Related Nuclear	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR.
other	36173547	hsa-mir-125a	AIDS-Related Complex	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. RESULTS: miR-125a-3p was upregulated in ARC tissues and LECs treated with UVB.
lncRNA target	36173547	hsa-mir-125a	Cataract	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. CONCLUSION: This study indicated that miR-125a-3p regulated apoptosis by suppressing TMBIM4 in LECs under oxidative damage, providing a new idea for clinical therapeutic target of cataract.
other	36173063	hsa-let-7b	Melanoma	CONCLUSION: In conclusion, we elucidated the regulatory role of the SNHG16-hsa-let-7b-5p-TUBB4A axis in the progression of skin cutaneous melanoma by modulating mitochondrial function to affect cellular metabolism.
genetics_overexpression_promote	36173030	hsa-mir-22	Colorectal Neoplasms	3p in CRC reduced YAP1 expression, whereas overexpression of KDM3A restored the expression of YAP1.
other	36173004	hsa-mir-210	Uterine Cervical Neoplasms	3p and modulates the progression of cervical cancer, which predict the prognosis of cervical cancer patients.
lncRNA target	36172919	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	The QKI-5 expression was anticorrelated with the miR-31 expression in NSCLC patient samples. CONCLUSION: Our results suggest that the miR-31/QKI-5/p21-CDK4-CDK6 axis might have critical functions in the progression of NSCLC, and targeting this axis could serve as a potential therapeutic strategy for NSCLC.
other	36172827	hsa-mir-485	Colorectal Neoplasms	CONCLUSION: Circ_0001535 promotes colorectal cancer cell development by absorbing miR5p and upregulating LASP1.
other	36172678	hsa-mir-409	Lung Neoplasms	CONCLUSION: miR3p may prevent non-small cell lung cancer (NSCLC) by affecting ELF2 transcription and other cellular regulators to regulate A549 cell division and induce apoptosis.
other	36172578	hsa-mir-370	Myocardial Reperfusion Injury	This study revealed that the lncRNA-HRAT/miR3p/RNF41 pathway regulates cardiomyocyte apoptosis and myocardial injury.
other	36172547	hsa-mir-192	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-223	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-26b	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-16-2	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-185	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-485	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-197	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-16	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-23a	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
genetics_GWAS	36172375	hsa-mir-146a	Autoimmune Diseases	Our work highlights the pathogenetic role of miR-146a and the potential of pharmacologic inhibition of TRAF6 in autoimmune diseases in which miR-146a is deregulated.
lncRNA target	36172098	hsa-mir-668	Alzheimer Disease	3p may be a potential therapeutic target for AD.
other	36172090	hsa-mir-149	Breast Neoplasms	Rutaecarpine prevents the malignant biological properties of breast cancer cells by the miR-149-3p/S100A4 axis.
other	36171887	hsa-mir-203a	Breast Neoplasms	An mRNA-miRNA network was built to identify an miR-203a-3p/LDHD/LYRM7 regulatory axis in BC.
other	36171576	hsa-mir-126	Adenocarcinoma of Lung	Transduction of miR3p is a potential therapeutic strategy for treating LUAD, yet the physiological environment and properties of miRNA challenge current transduction approaches.
other	36171191	hsa-mir-132	Neurotic Disorders	5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine.
other	36171191	hsa-mir-132	Rubella Syndrome, Congenital	5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine.
circRNA target	36171087	hsa-mir-647	Vascular Diseases	Circular RNA hsa_circ_0000345 (circ_0000345) and miR-647 are related to oxygenized low-density lipoprotein (ox-LDL)-induced arterial smooth muscle cell (ASMC) dysregulation.
genetics_overexpression_promote	36171087	hsa-mir-647	Angelman Syndrome	Mechanistically, circ_0000345 was verified as a miR-647 sponge, and miR-647 overexpression impaired the inhibitory effects of circ_0000345 upregulation on ox-LDL-induced ASMC proliferation, migration, invasion, and inflammatory response.
lncRNA target	36170021	hsa-mir-136	Carcinoma, Renal Cell	CONCLUSIONS: Our findings suggested that lncRNA NLGN1-AS1 could promote the progression of ccRCC by targeting miR5p/FZD4 and Wnt/beta-catenin pathway, and might serve as a novel potential therapeutic target to inhibit the progression of ccRCC.
genetics_knock down_suppress	36169673	hsa-mir-466f	Osteoporosis	* Knockdown of lncRNA NEAT1 inhibited osteoblast cells autophagy by sponging miRNA-466f-3p and targeting HK2 in osteoporosis.
other	36169175	hsa-mir-675	Adrenocortical Carcinoma	The downregulated expression of H19 in ACC compared to ACA correlated with miR675 expression hosted by H19.
genetics_knock down_promote	36169092	hsa-mir-506	Carcinoma, Hepatocellular	In HSC-CM cultured HCC cells, the effects of MIR4435-2HG knockdown on TGFB1 expression and HCC cell phenotypes were partially reversed by miR
other	36168936	hsa-mir-29a	Uterine Cervical Neoplasms	In conclusion, circ_0072995 promoted cervical cancer development by inducing miR-29a-mediated WDR5 expression.Impact statementWhat is already known on this subject? Global Cancer Statistics 2020 estimated that there were 1 021,494 new cases of cervical cancer and 439 201 deaths from cervical cancer. We first reported the promoting effects of circ_0072995 in cervical cancer development by inducing miR-29a mediated WDR5 expression and also revealed the therapeutic potential of circ_0072995, miR-29a, and WDR5 in cervical cancer.
lncRNA target	36168877	hsa-mir-18a	Ischemic Stroke	Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis.
lncRNA target	36168858	hsa-mir-144	Osteoporosis, Diabetic	In conclusion, this study indicated that HG regulated the migration, proliferation, and mineralization of osteoblasts via the miRNA
other	36168845	hsa-mir-619	Biliary Tract Neoplasms	3p represents a potentially valuable diagnostic strategy for identifying BTCs as well as a predictive indicator of BTC prognosis.
other	36168417	hsa-mir-122	Diabetes Mellitus, Type 2	The relationship of miR-126 and miR-122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR-126 expression was related to lower T2DM risk, FBG level and HOMA-IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index.
other	36167817	hsa-mir-26a	Respiratory Sounds	"RESULTS: Two infant factors (daycare attendance, family history of asthma) and three salivary ""omic"" features (miR-26a-5p, Elusimicrobia, Streptococcus phage phiARI0131-1) differed between the two groups (adjusted p < 0.05)."
circulation_biomarker_diagnosis_up	36167754	hsa-mir-182	high grade glioma	The proposed method was highly selective and possessed remarkable capability for evaluating the expression levels of miRNA-182 in serum samples from healthy donors and glioma patients.
lncRNA target	36167718	hsa-mir-451	Osteoarthritis	Moreover, when osteoarthritis (OA) was induced in Sprague Dawley rats via bilateral anterior cruciate ligament transection (ACLT), miR-451 expression was increased in OA cartilage compared to control, suggesting its inhibition might be used to prevent or treat OA. To examine the prophylactic and therapeutic potential of inhibiting miR-451, we evaluated treatment with miR-451 power inhibitor (451-PI) at the onset of joint trauma and treatment after OA had developed.
other	36167680	hsa-mir-890	Hemangioma, Cavernous	Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance.
other	36167680	hsa-mir-890	Hemangioma	Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance.
circulation_biomarker_diagnosis_up	36166353	hsa-mir-199a	Diabetic Neuropathies	Regarding the association between endoplasmic reticulum (ER) stress with the pathogenesis of neuropathy, this study aims to examine binding immunoglobulin protein (BiP) gene expression and long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1), miR-199a-5 as its regulator in the peripheral blood of DN patients compared to diabetic patients without neuropathy.
other	36165177	hsa-mir-96	Crohn Disease	5p had a better performance in recognizing active Crohn's disease with AUROC of 0.727 (95%CI 0.609-0.844, p = .001) than C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fecal calprotectin.
epigenetics	36165173	hsa-mir-1246	Lupus Erythematosus, Systemic	We found that increased histone H3 trimethylation at Lys(27) (H3K27me3) and decreased histone H3 acetylation at Lys(9) and Lys(14) (H3K9/K14ac) in the miR-1246 promoter region are essential for the low expression of miR-1246 in SLE B cells.
other	36164970	hsa-mir-125a	Lupus Erythematosus, Systemic	In conclusion, hsa_circ_0012919 regulated the pyroptosis in the CD4+ T cells of SLE patients by miR-125a-3p/GSDMD axis.
circulation_biomarker_diagnosis_ns	36164928	hsa-mir-296	Diabetes, Gestational	3p in peripheral blood samples from patients with GDM were measured using reverse transcription-quantitative polymerase chain reaction.
other	36164909	hsa-mir-20	Myocardial Reperfusion Injury	Compared with the sham group, the modeling of IR increased the myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and down-regulated the expression of miR-20 b-5 p(P&lt;0.05). The IR+RES+miR-20 b-5 p antagomir group had higher myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and lower expression of miR-20 b-5 p than the IR+RES group(P&lt;0.05).
genetics_knock down_promote	36164726	hsa-mir-656	Carcinoma, Non-Small-Cell Lung	3p downregulation or xCT overexpression partly overturned hsa_circ_0018189 knockdown or miR
lncRNA target	36164699	hsa-mir-338	Osteosarcoma	3p, which could be a new target for OS treatments.
other	36164683	hsa-mir-106b	Arthritis, Rheumatoid	The qRT-PCR results indicated that the expression of lncRNA HOTAIR was markedly decreased and that of miR-106b-5p was markedly increased in HFLSs of RA.
other	36164637	hsa-mir-223	Sepsis	CONCLUSION: Our study shows that all tested miRNAs can be used for early detection of sepsis, with miRNA-223 being predictive of mortality, hence preventing multi-organ failure and reducing mortality, and predicting poor outcomes, thereby assisting in early categorization of ICU patients for rapid appropriate treatment and medico legal aspects.
circRNA target	36164444	hsa-mir-146b	Colorectal Neoplasms	Rescue assays demonstrated circZC3HAV1 sponged miR-146b-3p and upregulated TBC1D9 to restrict migration and invasion of CRC cells. CONCLUSION: circZC3HAV1 could upregulate TBC1D9 via absorbing miR-146b-3p, consequently inhibiting migratory and invasive capabilities of CRC cells.
other	36164345	hsa-mir-187	Stomach Neoplasms	miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway.
genetics_overexpression_promote	36164322	hsa-mir-452	Carcinoma, Hepatocellular	The effects of HCC cell-derived exosomes on accelerating HCC migration and invasion and inducing M2 macrophage polarization were confirmed, which were further enhanced after overexpressing miR
transcription factor target	36163623	hsa-mir-153	Sepsis	Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage.
transcription factor target	36163623	hsa-mir-153	Lung Injury	Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage.
lncRNA target	36163622	hsa-mir-1	Sepsis	Objective To investigate whether long non-coding RNA-HOX transcript antisense intergenic RNA (lncRNA-HOTAIR) regulates the inflammatory response of sepsis by targeting microRNA miR3p.
lncRNA target	36162992	hsa-mir-575	Esophageal Squamous Cell Carcinoma	Mechanistically, RPL34-AS1 acted as a competing endogenous RNA (ceRNA) of miR-575 to relieve the repressive effect of miR-575 on its target ACAA2, then suppressed the tumorigenesis of ESCC.
transcription factor target	36162691	hsa-mir-146a	Depression	We also observed 74 miRNAs associated with depression that are targeted by curcumin, with hsa-miR-146a-5p having the greatest expression and interaction.
other	36162484	hsa-mir-205	Breast Neoplasms	MiR-205 and HELLS could be considered a novel diagnosis and therapeutic molecular marker of breast cancer.
other	36162459	hsa-mir-200a	Diabetes Mellitus	Furthermore, circSCMH1 was observed to induce HG cell growth and EMT by regulating the miR-200a-3p/ZEB1 axis.
genetics_overexpression_promote	36162436	hsa-mir-382	Squamous Cell Carcinoma of Head and Neck	In addition, overexpression of miR
lncRNA target	36162418	hsa-mir-144	Polycystic Ovary Syndrome	The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients.
lncRNA target	36162418	hsa-mir-224	Polycystic Ovary Syndrome	The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients.
other	36162367	hsa-mir-423	Pulmonary Disease, Chronic Obstructive	5p is a potential marker for identifying COPD patients.
other	36161443	hsa-mir-206	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-375	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-19b	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-424	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-221	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-28	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
genetics_knock down_promote	36161346	hsa-mir-508	Breast Neoplasms	CONCLUSION: Knockdown of hsa_circ_0002082 suppresses breast cancer growth and metastasis by miR3p/CENPF axis, suggesting that hsa_circ_0002082 may be a promising target for breast cancer treatment.
epigenetics	36161330	hsa-mir-193	Pituitary Neoplasms	In pituitary carcinomas, methylation of autosomal genes PARP15, LINC00599, MIR193 and ZAP70 was higher than in PAs/PITNETs, while X-linked genes methylation level was lower.
lncRNA target	36161300	hsa-mir-144	Uterine Cervical Neoplasms	CONCLUSION: Silencing circPUM1 may inhibit the proliferation, colony formation, migration, invasion and induce apoptosis of cervical cancer cells through targeting and regulating the expression of miR
transcription factor target	36161100	hsa-mir-4739	Osteoporosis	CONCLUSIONS: Overall, we proved that the higher expression of miR-4739 participated in the progression of osteoporosis by targeting ITGA10 and modulating PI3K/AKT signaling pathway, and perhaps miR-4739/ITGA10 axis could be potential diagnostic markers and therapeutic target for osteoporosis.
lncRNA target	36161098	hsa-mir-223	Myocardial Infarction	3p is a potential target for the treatment of myocardial infarction (MI).
genetics_knock down_suppress	36160904	hsa-mir-122	Osteochondritis Dissecans	5p and the knockdown of NDRG3 reversed the inhibitory effects of Meg3 overexpression on the proliferation, migration and angiogenesis of hCMEC/D3 cells subjected to OGD, as well as the promoting effects of Meg3 overexpression on cell apoptosis.
genetics_knock down_suppress	36160896	hsa-mir-3160	Lymphoma, Large B-Cell, Diffuse	Overall, the present study revealed that CACNA1G-AS1-knockdown and miR
transcription factor target	36160881	hsa-mir-146a	Inflammatory Bowel Diseases	At present, the biogenesis, function and role of miR-146a-5p in intestinal epithelial cells (IECs) during the pathogenesis of IBD remain elusive. Therefore, miR-146a-5p may act as an important diagnostic biomarker and treatment target of IBD.
lncRNA target	36160704	hsa-mir-372	Diabetic Cardiomyopathies	3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress.
lncRNA target	36160704	hsa-mir-372	Brain Ischemia	3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress.
other	36160329	hsa-mir-124	Spinal Cord Injuries	METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. CONCLUSIONS: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.
lncRNA target	36160034	hsa-mir-182	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
lncRNA target	36160034	hsa-mir-4506	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
lncRNA target	36160034	hsa-mir-7109	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
other	36160032	hsa-mir-4462	Breast Neoplasms	In this study, after performing GSEA and microarray analysis on the GSE71053 dataset, a new ceRNA network of CCDC18-AS1, LINC01343, hsa-miR4462, and SFN in BC was detected by bioinformatics analysis.
other	36160019	hsa-mir-133	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36160019	hsa-mir-195	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36160019	hsa-mir-181	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36159813	hsa-mir-29c	Head and Neck Neoplasms	Moreover, the LINC01270/hsa-miR-29c-3p/SFXN3 axis was identified as the most likely upstream non-coding RNA-related pathway of SFXN3 in HNSC using bioinformatic analysis, expression analysis, correlation analysis, and survival analysis.
lncRNA target	36159784	hsa-mir-3061	Intestinal Diseases	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159784	hsa-mir-3061	Sepsis	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159784	hsa-mir-3061	Diabetes Mellitus	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159592	hsa-mir-106b	Muscular Dystrophy, Duchenne	This study demonstrates that miR-106b is an important modulator of SC quiescence, and that miR-106b may be a new target to develop therapeutic strategies to promote muscle regeneration improving the regenerative capabilities of injured dystrophic muscle.
circRNA target	36159584	hsa-mir-140	Osteoarthritis	CONCLUSION: The upregulation of circKMT2E is involved in the chondrocyte apoptosis of the pathogenesis of OA through activation of TLR4 by the sponge function of miR
target gene	36159567	hsa-mir-135a	Liver Neoplasms	HBV Promotes the Proliferation of Liver Cancer Cells through the hsa_circ_0000847/miR-135a Pathway.
transcription factor target	36159559	hsa-mir-132	Cognition Disorders	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD.
transcription factor target	36159559	hsa-mir-132	REM Sleep Behavior Disorder	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD.
transcription factor target	36159559	hsa-mir-13	REM Sleep Behavior Disorder	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model.
transcription factor target	36159559	hsa-mir-13	Cognition Disorders	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model.
genetics_overexpression_suppress	36158838	hsa-mir-194	Angelman Syndrome	Overall, the current study demonstrated that LINC00452 overexpression reversed oxLDL-induced growth inhibition of HUVECs via regulating the miR5p/IGF1R axis, thus providing a potential beneficial targets for AS.
exosome	36158698	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells.
circulation_biomarker_diagnosis_down	36158656	hsa-mir-625	Neuroendocrine Tumors	CONCLUSIONS: Our study suggests that expression of plasma miRNAs miR
genetics_overexpression_promote	36158629	hsa-mir-26a	Carcinoma, Hepatocellular	miR-26a overexpression broadly inhibited the inflammatory response in both hepatocytes and macrophages by decreasing several key oncogenic signaling pathways in HCC promotion.
lncRNA target	36157880	hsa-mir-106a	Glioma	Further research showed that DCs after miR-106a/20b-mimics transfection could promote the inhibition of GSC proliferation by T cells in vitro and suppress tumour growth in vivo.
other	36157872	hsa-mir-326	Carcinoma, Hepatocellular	CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.
other	36157872	hsa-mir-424	Carcinoma, Hepatocellular	CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.
circulation_biomarker_prognosis_up	36157872	hsa-mir-511	Carcinoma, Hepatocellular	AIM: To assess the role of circulating miRNAs-326, miRNA-424, and miRNA-511 in Egyptian HCC patients.
other	36157551	hsa-mir-423	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups. In the validation cohort, only miR-21 and miR-423 could be confirmed as potential HCC biomarkers.
other	36157551	hsa-mir-320d	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups.
other	36157551	hsa-mir-21	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups.
other	36157524	hsa-mir-3682	Carcinoma, Hepatocellular	3p may represent a novel therapeutic strategy for HCC.
other	36157241	hsa-mir-26a	Stomach Neoplasms	Finally, we determined that the Taurine Upregulated 1 (TUG1)/hsa-miR-26a-5p/EIF4G2 axis was the most likely regulatory pathway involved in GC development. The TUG1/hsa-miR-26a-5p axis is a likely upstream regulatory mechanism of EIF4G2 in GC.
other	36157234	hsa-mir-375	Carcinoma, Hepatocellular	lncRNA TINCR Regulates Proliferation and Invasion of Hepatocellular Carcinoma Cells by Regulating the miR-375/ATG7 Axis.
lncRNA target	36157217	hsa-mir-520g	Triple Negative Breast Neoplasms	TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC.
lncRNA target	36157217	hsa-mir-520h	Triple Negative Breast Neoplasms	TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC.
genetics_overexpression_promote	36156852	hsa-mir-506	Colorectal Neoplasms	AKT2 overexpression or miR
target gene	36156333	hsa-mir-506	Breast Neoplasms	MicroRNA-506 ameliorates breast cancer-induced osteolytic bone metastasis via the NFATc-1 signaling pathway.
lncRNA target	36156291	hsa-mir-599	Angelman Syndrome	CONCLUSION: Our findings illustrated that curcumin exhibited anti-AS effect through the miR-599/MYD88 axis and thereby inhibiting the NF-kappaB pathway.
lncRNA target	36156150	hsa-let-7b	Breast Neoplasms	Expression of SMUG1 and hsa-let-7b-5p were negatively correlated in breast cancer and we found an inhibitory auto-regulatory loop between SMUG1 and hsa-let-7b-5p in the MCF7 breast cancer cells.
other	36155856	hsa-mir-196a-2	Abortion, Septic	hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Estimation of the Odds Ratios indicated that the chance of recurrent abortions in TT genotypes of miRNA196a-2 was about three times more likely than CC in non-infected individuals and about five times more likely than CC in M.
other	36155856	hsa-mir-196a-2	Hodgkin Disease	hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Our results proposed the role of miRNA196a-2 genotypes in RPL either in M.
circulation_biomarker_diagnosis_up	36155776	hsa-mir-515	Pre-Eclampsia	5p may play critical roles in the pathogenesis of preeclampsia through suppression of XIAP, and serum miR
genetics_overexpression_promote	36155610	hsa-mir-10a	Pancreatitis	Finally, rescue experiments proved that KLF4 overexpression or miR-10a-5p suppression enhanced pyroptosis of AP acinar cells. Overall, USP25 stabilized KLF4 expression through deubiquitination, limited miR-10a-5p expression, and increased GSDMD expression, finally promoting pyroptosis of acinar cells in AP.
exosome	36155593	hsa-mir-193b	Seminoma	Taken together, these findings indicate that exosomal miR-193b-3p regulates the chemosensitivity of TCam-2 cells to cisplatin through ZBTB7A signaling and could be a promising drug target for patients with chemoresistant seminoma.
circulation_biomarker_diagnosis_up	36155522	hsa-mir-146a	Cognitive Dysfunction	OBJECTIVE: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n = 12), people with mild cognitive impairment (MCI, n = 9), and normocognitive group (CTRL, n = 18).
genetics_knock down_promote	36155410	hsa-mir-199a	Intervertebral Disc Degeneration	CDKN1B knockdown partially abrogated the effects of miR-199a-5p inhibition on DNPC proliferation and apoptosis.
circRNA target	36155326	hsa-mir-625	Squamous Cell Carcinoma of Head and Neck	5p/STAT3 axis to activate JAK/STAT3 signaling pathway, consequently facilitating OSCC cell proliferation and inhibiting cell apoptosis.
lncRNA target	36155216	hsa-mir-6499	Liver Cirrhosis	CONCLUSION: Sal B suppresses HSC activation and liver fibrosis via regulation of miR3p/LncRNA-ROR-mediated NF-kappaB signaling pathway.
lncRNA target	36155181	hsa-mir-21	Pulmonary Fibrosis	Treatment with either NaHS or BM-MSC leads to an inhibitory effect on pulmonary fibrosis as evidenced by improvement of histopathological studies, pulmonary function tests, reduction of inflammatory and fibrotic markers like Hydroxyproline, TNF alpha, TGF-beta and caspase -3 together with downregulation miR-21 and increase lncRNA-GAS5 expression. SIGNIFICANCE: The current work revealed the inhibitory effect of combined NaHS and BM-MSC on pulmonary fibrosis with concomitant modulation of miR-21 and lncRNA-GAS5 expression.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-181c	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-34a	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-29b	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
other	36154667	hsa-mir-486	Diabetic Nephropathies	5p-CSF2RB presents a biomarker axis to the occurrence and development of DN.
other	36154667	hsa-mir-155	Diabetic Nephropathies	5p-CSF2RB presents a biomarker axis to the occurrence and development of DN.
other	36154076	hsa-let-7g	Liver Neoplasms	In an aggressive MYC-driven liver cancer model relevant to hepatocytes, 5A2-SC8 LNPs carrying let-7g miRNA were able to significantly extend survival up to 121 days.
genetics_knock down_promote	36153644	hsa-mir-16	Sepsis	Knockdown of miR
genetics_overexpression_promote	36153605	hsa-mir-1286	Osteosarcoma	OS cell progression was suppressed by miR-1286 overexpression via downregulating MAFB.
lncRNA target	36153499	hsa-mir-155	Pre-Eclampsia	CONCLUSION: LINC00240 inhibited symptoms of preeclampsia through regulation on miR-155/Nrf2 axis, which suppressed oxidative stress-induced pyroptosis to improve trophoblast function and M2 macrophage polarization.
lncRNA target	36153449	hsa-mir-126	Brain Ischemia	OBJECTIVE: To observe the effect of electroacupuncture (EA) on miRNA3p and mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway in rats with cerebral ischemia (CI), so as to explore the underlying mechanism of EA on angiogenesis.
lncRNA target	36153434	hsa-mir-770	Diabetic Nephropathies	CONCLUSIONS: These results suggest that circ ASAP2 decreased inflammation and ferroptosis in DN through SOX2/SLC7A11 by miR
other	36153426	hsa-mir-664b	Alzheimer Disease	Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure.
other	36153426	hsa-mir-651	Alzheimer Disease	Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure.
lncRNA target	36153370	hsa-mir-648	Stomach Neoplasms	Our studies suggest that miR-3648 acts as a tumour-suppressive miRNA and that the miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop could be a critical regulator of GC progression.
lncRNA target	36153332	hsa-mir-760	Breast Neoplasms	We then verified that HM13 was a direct target of miR-760 functioned as a tumor -suppressor in breast cancer. Taken together, these findings elucidated that HM13, targeted by miR-760, could play an oncogenic role in breast cancer by inducing autophagic inhibition and facilitating PI3K-AKT-mTOR pathway.
other	36153316	hsa-mir-216a	nonpapillary renal cell carcinoma	Furthermore, USP1 and survivin protein expression showed a positive correlation, whereas miR-216a-5p and DR5 were inversely correlated in RCC tumor tissues.
lncRNA target	36153002	hsa-mir-29b	Fibrosis, Renal	In general, our data show that circRNA_33702 may promote renal fibrosis via the miR-29b-3p/WISP1 axis, which may potentially be developed as a new therapeutic target.
exosome	36152993	hsa-mir-100	Colorectal Neoplasms	Collectively, our data indicated that MSC-Exos could suppress proliferation, migration, invasion and metastasis while inducing the apoptosis of the CRC cells via miR-100/mTOR/miR-143 axis.
lncRNA target	36152745	hsa-mir-34c	Memory Disorders	In conclusion, miR-34c antagomir may be considered as a promising novel therapeutic target for AD patients.
transcription factor target	36151071	hsa-mir-138	Endometrial Neoplasms	Further mechanistic studies indicated that miR5p was a tumor suppressor in PSCC by inhibiting the translation of HOXD11 post-transcriptionally through binding to the 3' untranslated region.
transcription factor target	36151071	hsa-mir-138	Penile Neoplasms	Further mechanistic studies indicated that miR5p was a tumor suppressor in PSCC by inhibiting the translation of HOXD11 post-transcriptionally through binding to the 3' untranslated region.
transcription factor target	36150742	hsa-mir-495	Huntington Disease	3p, which inhibit Prr7 mRNA translation and are required for HSD.
transcription factor target	36150742	hsa-mir-29	Huntington Disease	3p, which inhibit Prr7 mRNA translation and are required for HSD.
other	36150451	hsa-mir-183	Muscular Atrophy	Carnosol at 5 to 20 muM could dose-dependently ameliorate the myotube atrophy induced by miR5p.
lncRNA target	36150451	hsa-mir-183	Cachexia	5p, based on both its inhibiting effects on MuRF-1 and Atrogin
other	36149935	hsa-mir-21	Heart Failure	Besides, the levels of miR-21 and -23 were significantly lower in patients with ischemia-induced HF.
other	36149935	hsa-mir-1	Heart Failure	5-p can be taken into account as diagnostic aids for AHF.
other	36149935	hsa-mir-23	Heart Failure	Besides, the levels of miR-21 and -23 were significantly lower in patients with ischemia-induced HF.
other	36149758	hsa-mir-326	Pancreatic Carcinoma	3p/TUFT1/AKT-mTOR axis.
lncRNA target	36149748	hsa-mir-135b	Rhinitis, Allergic	MALAT1 facilitated AR development by facilitating CD4(+) T cell Th2 differentiation via the miR-135b-5p/GATA-3 axis.
lncRNA target	36148952	hsa-mir-140	Fibrosis, Renal	Collectively, this study highlights that TUG1 inhibition upregulates miR
lncRNA target	36148952	hsa-mir-140	Hyperuricemia	Collectively, this study highlights that TUG1 inhibition upregulates miR
genetics_knock down_promote	36148947	hsa-mir-182	Liver Cirrhosis	Knockdown or overexpression of miR
exosome	36148757	hsa-mir-30	Lung Neoplasms	All results suggested that exosomal transfer of circSATB2 contributed to the malignant development of lung cancer by acting as a sponge of miR
genetics_knock down_promote	36148577	hsa-mir-149	Colorectal Neoplasms	CONCLUSIONS: Circ_0003602 knockdown impedes CRC development by targeting the miR
target gene	36147907	hsa-mir-145	Prostatic Neoplasms	microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition.
other	36147635	hsa-mir-4746	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-671	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-126	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-556	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-19a	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-4664	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147635	hsa-mir-937	Adenocarcinoma of Lung	5p) could apparently improve the OS rate of patient with LUAD.
other	36147570	hsa-mir-150	limb ischemia	5p may be sensitive risk markers for predicting endothelial dysfunction in patients with ATH (ATH and SCH+ATH groups).
other	36147570	hsa-mir-21	limb ischemia	CONCLUSIONS: miR5p may be involved in the atherosclerosis process in patients with SCH (SCH and SCH+ATH groups).
genetics_knock down_suppress	36147545	hsa-mir-936	Osteosarcoma	RESULTS: Increased circDOCK1 and LEF1, and decreased miR-936 were found in OS tissues and cell lines. CONCLUSION: CircDOCK1 knockdown might attenuate OS cell malignant biological behaviors by regulating the miR-936/GFRA1 axis, which may highlight the diagnostic and therapeutic potential of these molecules for OS treatment.
genetics_GWAS	36147476	hsa-mir-34a	Colorectal Neoplasms	Mir34a-inactivation related expression signatures were associated with CMS4/CRISB+D, stage 4 CRCs and poor patient survival. This study provides genetic evidence for a requirement of Mir34a-mediated Csf1r suppression for intestinal stem/secretory cell homeostasis and tumor suppression, and suggests that therapeutic targeting of CSF1R may be effective for the treatment of CRCs with defects in the p53/miR-34a pathway.
other	36147476	hsa-mir-34a	Colorectal Neoplasms, Hereditary Nonpolyposis	mRNAs containing Mir34a seed-matching sites, which encode proteins related to EMT (epithelial-mesenchymal transition), stemness and Wnt signaling, were enriched after Mir34a inactivation in adenomas and derived tumoroids.
other	36147476	hsa-mir-34a	Adenoma	mRNAs containing Mir34a seed-matching sites, which encode proteins related to EMT (epithelial-mesenchymal transition), stemness and Wnt signaling, were enriched after Mir34a inactivation in adenomas and derived tumoroids.
transcription factor target	36147476	hsa-mir-34a	Intestinal Neoplasms	However, the in vivo relevance of the suppression of CSF1R by miR-34a for intestinal tumor suppression mediated by the p53/miR-34a pathway has remained unknown.
other	36144224	hsa-mir-592	overactive bladder syndrome	5p and miR-592 in urine could be a useful and non-invasive tool for the diagnosis of OAB syndrome in aging women.
lncRNA target	36143385	hsa-mir-155	Bone Pain	5p restored Sgk3-expression-attenuated microglial activation and alleviated hyperalgesia in the BCP rats.
lncRNA target	36143385	hsa-mir-155	Hyperalgesia	5p restored Sgk3-expression-attenuated microglial activation and alleviated hyperalgesia in the BCP rats.
other	36143269	hsa-mir-1290	Sjogren's Syndrome	Logistic regression analysis revealed a more significant influence of miR-1290 and let-7b-5p in the SS group than that in the control group. The combination of miR-1290 and let-7b-5p distinguished SS from the control samples with an AUC, sensitivity, specificity, positive predictive value, and negative predictive value of 0.856, 91.7%, 83.3%, 84.6%, and 90.9%, respectively.
other	36143269	hsa-let-7b	Sjogren's Syndrome	Logistic regression analysis revealed a more significant influence of miR-1290 and let-7b-5p in the SS group than that in the control group. The combination of miR-1290 and let-7b-5p distinguished SS from the control samples with an AUC, sensitivity, specificity, positive predictive value, and negative predictive value of 0.856, 91.7%, 83.3%, 84.6%, and 90.9%, respectively.
other	36143090	hsa-mir-34a	Pneumonia	RESULTS: Asthmatic patients had a significant lower expression of hsa-miR-34a-5p, 181a-5p and 146a-5p compared to both obese and healthy ones suggesting microRNAs' specific involvement in the regulation of lungs inflammatory response.
other	36142883	hsa-mir-126	Carotid Artery Diseases	Down-regulation of miR5p expression has been identified as a promising biomarker of advanced carotid atherosclerosis with high specificity and sensitivity.
other	36142883	hsa-mir-33a	Carotid Artery Diseases	5p with ADAMTS13, erythrocyte sedimentation rate and D-dimer (r = 0.42, r = 0.36 and r = 0.44, respectively, p < 0.05); stenosis degree with miR-33a-5p/3p and factor VIII levels (r = 0.43 (both) and r = 0.62, respectively, p < 0.05).
other	36142712	hsa-mir-29a	Testicular Diseases	album and two of its isolated compounds, rutin and the new saponin zygo-albuside A, against methotrexate (MTX)-induced testicular injury, considering the role of miRNA-29a. The mRNA expression levels of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), p53, and miRNA-29a were downregulated in the testicular tissues of the protected groups compared with the unprotected group.
other	36142686	hsa-mir-1290	Enzootic Bovine Leukosis	bta-miR-1246 and hsa-miR5p, but not hsa-miR-1290, were detected using qPCR and their levels in milk sEVs from EBL cattle were significantly higher than those in BLV-uninfected cattle.
transcription factor target	36142686	hsa-mir-424	Enzootic Bovine Leukosis	5p in sEVs may promote metastasis by targeting tumor suppressor genes, resulting in increased amounts in milk sEVs in EBL cattle.
other	36142646	hsa-mir-29a	Scleroderma, Systemic	All of the rest of the analyzed microRNAs, excluding miR-126, miR-29a and miR-181a, were significantly upregulated in SSc patients in comparison to HC.
other	36142646	hsa-mir-132	Scleroderma, Systemic	Additionally, the expression of miR-132 was significantly higher in dcSSc subgroup with detected active lung lesions compared to dcSSc patients with fibrotic lesions.
circulation_biomarker_diagnosis_ns	36142646	hsa-mir-181a	Scleroderma, Systemic	However, miR-181a has been revealed only in the serum of patients with lcSSc but not dcSSc.
other	36142646	hsa-mir-126	Scleroderma, Systemic	All of the rest of the analyzed microRNAs, excluding miR-126, miR-29a and miR-181a, were significantly upregulated in SSc patients in comparison to HC.
other	36142607	hsa-mir-494	Squamous Cell Carcinoma of Head and Neck	Using the human OSCC cell lines HSC3 and HSC4, we demonstrate that HOXA11-AS promotes NQO1 expression by sponging microRNA-494.
exosome	36142562	hsa-mir-484	Hodgkin Disease	Finally, microRNA analysis in HL-60 and HL-60/ADR cells and exosomes showed that miR-484 elevation in HL-60/ADR cells and exosomes was associated with exosome-mediated cell proliferation.
genetics_GWAS	36142557	hsa-let-7a-1	Leprosy	The rs10739971 (pri-let-7a1) polymorphism was associated with the development of leprosy, while rs2910164 (miR146A) and rs10035440 (DROSHA) was significantly associated with an increased risk of developing multibacillary leprosy.
genetics_GWAS	36142557	hsa-mir-4513	Leprosy	In contrast, the SNPs rs10739971 (pri-let-7a1), rs12904 (miR200C), and rs2168518 (miR4513) are associated with the development of the paucibacillary leprosy.
genetics_GWAS	36142557	hsa-mir-200c	Leprosy	In contrast, the SNPs rs10739971 (pri-let-7a1), rs12904 (miR200C), and rs2168518 (miR4513) are associated with the development of the paucibacillary leprosy.
genetics_GWAS	36142557	hsa-mir-146a	Leprosy	The rs10739971 (pri-let-7a1) polymorphism was associated with the development of leprosy, while rs2910164 (miR146A) and rs10035440 (DROSHA) was significantly associated with an increased risk of developing multibacillary leprosy.
exosome	36142544	hsa-mir-1307	Squamous Cell Carcinoma of Head and Neck	Conclusions: Salivary exosomal miRNA5p is a potential prognosticator for predicting poor survival and poor patient outcome in oral cancers.
other	36142536	hsa-mir-20b	Diabetes, Gestational	3p).
other	36142536	hsa-mir-20b	Abortion	3p).
other	36142536	hsa-mir-20b	Cardiovascular Diseases	3p).
other	36142536	hsa-mir-195	Diabetes, Gestational	3p).
other	36142536	hsa-mir-20a	Cardiovascular Diseases	3p).
other	36142536	hsa-mir-195	Abortion	3p).
other	36142536	hsa-mir-20a	Diabetes, Gestational	3p).
other	36142536	hsa-mir-195	Cardiovascular Diseases	3p).
other	36142536	hsa-mir-20a	Abortion	3p).
genetics_overexpression_promote	36142477	hsa-mir-3687	Prostatic Neoplasms	PCa and CRPC cell lines were transfected with miR-3687 or miR-4417 to overexpress the miRNAs.
genetics_overexpression_promote	36142477	hsa-mir-4417	Prostatic Neoplasms	PCa and CRPC cell lines were transfected with miR-3687 or miR-4417 to overexpress the miRNAs.
other	36142465	hsa-mir-29-2	Plaque, Amyloid	5p expression in the frontal cortex region.
other	36142465	hsa-mir-29b-2	Plaque, Amyloid	5p expression in the frontal cortex region.
other	36142307	hsa-mir-486	Hypertension, Pulmonary	5p during PAH development.
lncRNA target	36142220	hsa-mir-93	Periodontitis	The objective of the present study was to explore hypoxia-related miRNA target genes for HIF-1alpha and NFAT5, as well as miRNA-20a, miRNA-30e, and miRNA-93 expression in periodontitis versus healthy gingival tissues and gingival mesenchymal stem cells (GMSCs) cultured under hypoxic conditions.
lncRNA target	36142220	hsa-mir-20a	Periodontitis	The objective of the present study was to explore hypoxia-related miRNA target genes for HIF-1alpha and NFAT5, as well as miRNA-20a, miRNA-30e, and miRNA-93 expression in periodontitis versus healthy gingival tissues and gingival mesenchymal stem cells (GMSCs) cultured under hypoxic conditions.
other	36142200	hsa-mir-194	Zika Virus Infection	We observed downregulation of miR-302b, miR-302c and miR-194, whereas miR-30c was upregulated in ZIKV infected human NPCs in vitro.
genetics_overexpression_suppress	36142173	hsa-mir-155	Plaque, Atherosclerotic	3p overexpression decreased IGF-IIR reducing apoptosis in vascular cells; (4) Conclusions: Our results suggest that miR
genetics_overexpression_suppress	36142173	hsa-mir-143	Plaque, Atherosclerotic	3p overexpression decreased IGF-IIR reducing apoptosis in vascular cells; (4) Conclusions: Our results suggest that miR
transcription factor target	36142146	hsa-mir-142	Stroke	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
transcription factor target	36142146	hsa-mir-142	COVID-19	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
transcription factor target	36142146	hsa-mir-142	Zika Virus Infection	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
transcription factor target	36142146	hsa-mir-142	Hemorrhagic Fever, Ebola	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
transcription factor target	36142146	hsa-mir-142	Dengue	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
transcription factor target	36142146	hsa-mir-142	Infections	Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.
other	36140836	hsa-mir-122	Carcinoma, Hepatocellular	miR-122 was highly expressed in HCV patients with a significant difference from the HCC group (p = 0.004), which points towards its role in prognosis value as a predictor of HCC in patients with chronic HCV.
lncRNA target	36140796	hsa-mir-138	Urinary Bladder Neoplasms	5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion.
lncRNA target	36140796	hsa-mir-124	Urinary Bladder Neoplasms	5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion.
lncRNA target	36140796	hsa-let-7a	Urinary Bladder Neoplasms	5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion.
other	36140779	hsa-mir-205	Endometrial Neoplasms	Paired samples of tumor-adjacent tissues and primary tumors from 49 patients with endometrial cancer (EC), samples of endometrium from 25 patients with leiomyomas of the uterus, and 4 endometrial cancer cell lines were examined by the RT-qPCR, for MYC, NR5A2, CXCR2, HMGA2, LIN28A, OCT4A, OCT4B, OCT4B1, TWIST1, STK11, SNAI1, and miR5p expression.
lncRNA target	36140281	hsa-mir-499	Cardiomyopathy, Hypertrophic	target genes, SOX6 and PTBP3, were upregulated in HCM.
other	36140249	hsa-mir-200b	Colorectal Neoplasms	We found upregulation of miR-200b and ONECUT2 in CRC pT3 and pT4a compared to normal mucosa, and downregulation of CDKN1B in CRC pT3. Moreover, we observed, downregulation of miR-200b, PTPN13 and ZEB2 in CRC with serosal invasion (pT4a) compared to pT3.
lncRNA target	36140236	hsa-mir-18a	Cardiovascular Diseases	We confirmed the pro-atherogenic effect of miR-18a-5p in subclinical CVD and identified several target genes for future CVD therapies.
lncRNA target	36140165	hsa-mir-93	Endometriosis	Three miRNAs, let-7b and miR-92a-3p, and miR5p potentially targeted KIAA1324, an estrogen-responsive gene and one of the most downregulated genes in OMA.
circulation_biomarker_diagnosis_ns	36139786	hsa-mir-122	Reperfusion Injury, Renal Ischemia	5p expression, pNF-kappaB expression, Bax/caspase 3/poly(ADP-ribose) polymerase (PARP)-mediated apoptosis, blood urea nitrogen, and creatinine levels.
other	36139749	hsa-mir-21	Vascular Diseases	Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies.
other	36139749	hsa-mir-126	Vascular Diseases	Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies.
other	36139749	hsa-mir-126	Diabetes Mellitus, Type 2	Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies.
other	36139749	hsa-mir-21	Diabetes Mellitus, Type 2	Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies.
genetics_overexpression_promote	36139455	hsa-mir-155	Cholangitis, Biliary, Primary	RESULTS: A reduction of PPARalpha in primary biliary cholangitis (PBC) livers was associated with miR-21 and miR-155 upregulation. CONCLUSIONS: Hepatic PPARalpha expression is reduced in PBC livers as a likely result of miR-155 overexpression.
other	36139455	hsa-mir-21	Cholangitis, Biliary, Primary	RESULTS: A reduction of PPARalpha in primary biliary cholangitis (PBC) livers was associated with miR-21 and miR-155 upregulation.
genetics_overexpression_promote	36139435	hsa-mir-22	Carcinoma, Hepatocellular	MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Our study demonstrates that miR-22 acts as a hepatic tumor suppressor in vivo by restraining pro-carcinogenic metabolic deregulations through pleiotropic mechanisms and the overexpression of relevant oncogenes.
genetics_overexpression_promote	36139435	hsa-mir-22	Fatty Liver	MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Our study demonstrates that miR-22 acts as a hepatic tumor suppressor in vivo by restraining pro-carcinogenic metabolic deregulations through pleiotropic mechanisms and the overexpression of relevant oncogenes.
other	36139316	hsa-mir-188	Opitz GBBB Syndrome, X-Linked	At the same time, miR5p expression in Exo-OS was significantly higher than in Exo-MS (p < 0.01), implying that it may play an important role in regulating the lifespan and reproductive potential of sows.
other	36139316	hsa-mir-188	Multiple Sclerosis	At the same time, miR5p expression in Exo-OS was significantly higher than in Exo-MS (p < 0.01), implying that it may play an important role in regulating the lifespan and reproductive potential of sows.
circulation_biomarker_diagnosis_ns	36139082	hsa-mir-223	Myocardial Infarction	Conclusions-Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
circulation_biomarker_diagnosis_ns	36139082	hsa-mir-186	Myocardial Infarction	Conclusions-Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
circulation_biomarker_diagnosis_ns	36139032	hsa-mir-29a	Fetal Growth Retardation	Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63.
circulation_biomarker_diagnosis_ns	36139032	hsa-mir-29	Skeletal Muscle Dysplasia	Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63.
circulation_biomarker_diagnosis_ns	36139032	hsa-mir-29a	Skeletal Muscle Dysplasia	Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63.
circulation_biomarker_diagnosis_ns	36139032	hsa-mir-29	Fetal Growth Retardation	Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63.
other	36138893	hsa-mir-223	Brain Injuries	MiR-223 is a miRNA with important functions in apoptosis, carcinogenesis, and inflammation, and it was demonstrated to be over-expressed in brain tissue after traumatic brain injury (TBI). Moreover, miR-223 may play a role in maintaining the integrity of BBB during TBI.
circulation_biomarker_diagnosis_ns	36138476	hsa-mir-486	Hemolysis	RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis.
circulation_biomarker_diagnosis_ns	36138476	hsa-mir-451	Hemolysis	RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis.
circulation_biomarker_diagnosis_ns	36138476	hsa-mir-16	Hemolysis	RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis.
circulation_biomarker_diagnosis_ns	36138476	hsa-mir-191	Hemolysis	RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis.
circulation_biomarker_diagnosis_ns	36138476	hsa-mir-92a	Hemolysis	RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis.
genetics_overexpression_suppress	36138468	hsa-mir-99a	Pulmonary Fibrosis	Therefore, overexpression of MIR99AHG may provide a new approach to preventing LUAD progression.
circulation_biomarker_diagnosis_ns	36138395	hsa-mir-576	Atherosclerosis	3p/IFIT1/STAT1 feedback loop participates in atherosclerosis progression and contributes to the high circ_0086296 expression observed in the exosomes of serum of patients with atherosclerosis.
genetics_overexpression_promote	36138344	hsa-mir-27b	Carcinoma, Hepatocellular	Recombinant oncolytic adenovirus (Onco(Ad)) overexpressing hsa-miR-27b was constructed to detect their therapeutic value in HCC.
genetics_overexpression_promote	36138295	hsa-mir-34b	Liver Cirrhosis	Conclusively, overexpressing miR-34b-5p reduced TGF-beta-induced HSC activation by inhibiting EZH2 and thereby promoting MFGE8 expression, and inhibited liver fibrosis in vivo through the EZH2/MFGE8 axis.
transcription factor target	36137407	hsa-mir-21	Mental Disorders	Notably, a set of dysregulated miRNA signatures including hsa-mia-451a and hsa-mir-21a resulted in an AUC of 0.966 and 0.861, respectively, for predicting the patients with SUDs.
other	36137399	hsa-mir-26b	Salivary Gland Neoplasms	Also, miR-26b was selectively increased in pleomorphic adenomas of the salivary gland.
other	36137399	hsa-mir-200a	Salivary Gland Neoplasms	Remarkably, we found that miR-200a and miR-373 were significantly upregulated whereas miR-30c were downregulated in tissues of patients with salivary gland tumors, compared to adjacent healthy tissue samples.
other	36137399	hsa-mir-145	Salivary Gland Neoplasms	Additionally, miR-145 and miR-30a were found to be specifically downregulated in a mucoepidermoid carcinoma.
other	36137399	hsa-mir-373	Salivary Gland Neoplasms	Remarkably, we found that miR-200a and miR-373 were significantly upregulated whereas miR-30c were downregulated in tissues of patients with salivary gland tumors, compared to adjacent healthy tissue samples.
lncRNA target	36136991	hsa-mir-16	Breast Neoplasms	5p/UBE2C axis might be a prospective therapeutic target in the BC treatment by sponging miR
circRNA target	36136989	hsa-mir-185	Multiple Myeloma	Circ_0005615 contributed to the malignant progression and bortezomib resistance of multiple myeloma through mediating miR
genetics_knock down_suppress	36136988	hsa-mir-1271	Endometrial Neoplasms	5p, and its overexpression eliminated the promotion effect of miR
genetics_knock down_suppress	36136987	hsa-mir-136	Prostatic Neoplasms	5p inhibitor or TRIB1 overexpression.
transcription factor target	36136972	hsa-mir-206	Breast Neoplasms	Our results showed that miR-206 mimics suppressed CALR expression, inhibited the proliferation and metastasis ability of breast cancer stem cells and finally induced cellular apoptosis.
circulation_biomarker_diagnosis_ns	36136693	hsa-mir-192	Polyps	Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated.
circulation_biomarker_diagnosis_ns	36136693	hsa-mir-192	Gastrointestinal Neoplasms	Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated.
circulation_biomarker_diagnosis_ns	36136693	hsa-mir-20b	Gastrointestinal Neoplasms	Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated.
circulation_biomarker_diagnosis_ns	36136693	hsa-mir-20b	Polyps	Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated.
transcription factor target	36136257	hsa-mir-17	Melanoma	Taken together, our results suggest that quercetin can regulate cell proliferation and apoptosis through TET1 via miR-17 in melanoma cells.
other	36135175	hsa-mir-942	Stomach Neoplasms	In conclusion, this study demonstrated that hsa-miR3p could be a potential prognostic marker of gastric cancer associated with the AR and MAPK/ERK signaling pathways.
genetics_overexpression_promote	36135094	hsa-mir-1287	Leukemia, Myeloid, Acute	5p expression was down-regulated in AML patients and up-regulated in circ_0059707-overexpressing cells.
lncRNA target	36134741	hsa-mir-520h	Stomach Neoplasms	Furthermore, CDC42 was a functional target of miR-520h in regulating GC cell behaviors.
exosome	36133788	hsa-mir-34c	Constipation	BACKGROUND: The pathogenesis of slow transit constipation (STC) is associated with exosomal miR-34c-5p. CONCLUSION: Our results indicated that EA improves intestinal motility in STC rats by transporting of exosomal miR-34c-5p targeting the SCF/c-Kit signaling pathway.
lncRNA target	36133483	hsa-mir-24	Myocardial Infarction, Acute	MicroRNA-24 (miR-24) is an apoptosis suppressor miRNA downregulated in cardiomyocytes after acute myocardial infarction (AMI). However, due to the lack of effective delivery strategies, the role of anti-apoptotic miR-24 in cardiomyocytes post-acute myocardial infarction remains unexplored.
lncRNA target	36132985	hsa-mir-34a	Spinal Cord Injuries	Notably, in the post-SCI rat model, exogenous miR-34a-3p agomir obviously inhibited the expression of PDCD6 at the protein level and promoted neuronal proliferation, motoneurons regeneration, and axonal myelination. Conclusively, this paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway.
lncRNA target	36131212	hsa-mir-124	Microvascular Obstruction	Collectively, PPG alleviates ischemia-induced neuronal damage and microglial inflammation by modulating the miR3p/TRAF6/NF-kappaB pathway.
epigenetics	36130949	hsa-mir-663	Obesity, Maternal	Brain and cffDNA methylation levels from a large region overlapping mir-663 correlated with maternal obesity, metabolic and immune markers, and infant behavior.
exosome	36129637	hsa-mir-140	Subarachnoid Hemorrhage	Collectively, our findings indicated that ADSC-Exos-miR
lncRNA target	36129629	hsa-let-7a	Developmental Disabilities	In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest.
lncRNA target	36129629	hsa-let-7a	Heart Arrest	In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest.
lncRNA target	36129629	hsa-let-7g	Developmental Disabilities	In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest.
lncRNA target	36129629	hsa-let-7g	Heart Arrest	In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest.
lncRNA target	36129595	hsa-mir-486	Myocardial Infarction	5p and upregulation of XIST inhibited hypoxic injury by downregulating miR
lncRNA target	36129595	hsa-mir-4486	Myocardial Infarction	5p and upregulation of XIST inhibited hypoxic injury by downregulating miR
other	36129161	hsa-mir-22	Mitochondrial Diseases	Treatment of PC12 cells with STZ resulted in mitochondrial dysfunction and increased autophagic markers, including LC3-II, Beclin1, Akt, ATG genes, and accumulation of miR-21 and miR-22.
other	36129161	hsa-mir-21	Mitochondrial Diseases	Treatment of PC12 cells with STZ resulted in mitochondrial dysfunction and increased autophagic markers, including LC3-II, Beclin1, Akt, ATG genes, and accumulation of miR-21 and miR-22.
circulation_biomarker_diagnosis_down	36128917	hsa-mir-181b	Cerebral Hemorrhage	Further studies on the plasma lncRNA-MEG3, miR-181b, and UCH-L1 levels in patients with ICH could yield novel biological targets for the prediction and treatment of ICH.
transcription factor target	36128801	hsa-mir-1275	Obesity, Abdominal	Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases.
transcription factor target	36128801	hsa-mir-1275	Obesity	Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases.
transcription factor target	36128801	hsa-mir-1275	Metabolic Diseases	Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases.
lncRNA target	36128198	hsa-mir-378	Pulmonary Disease, Chronic Obstructive	miR-378 increased in COPD lung tissues while NPNT decreased, and might prove a potential target for novel drug therapy.
genetics_overexpression_suppress	36128051	hsa-mir-524	Prostatic Neoplasms	The overexpression of miR
genetics_overexpression_suppress	36128051	hsa-mir-524	Breast Neoplasms	The overexpression of miR
genetics_overexpression_promote	36127685	hsa-mir-99a	Osteoarthritis, Spine	At the molecular level, miR-99a overexpression downregulated the levels of MMP13, beta-catenin, Bax, and caspase-3 protein expression and upregulated the levels of COL2A1 and Bcl-2 protein expression in the in vitro OA-like chondrocyte model and also in the experimental OA model rats.
lncRNA target	36127622	hsa-mir-193a	Triple Negative Breast Neoplasms	Additionally, LINC01224 stabilized NUP210 mRNA through interaction with miR-193a-5p, thereby aggravating the malignant phenotypes of TNBC.
genetics_overexpression_promote	36126797	hsa-mir-345	Liver Cirrhosis	Furthermore, overexpression of miR
genetics_overexpression_promote	36126276	hsa-mir-151	Head and Neck Neoplasms	3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls.
other	36126189	hsa-mir-450b	Reperfusion Injury, Renal Ischemia	Furthermore, the expression levels of Nrf2 and it-dependent antioxidant enzymes were apparently increased in ischemic kidney after the transfection of miR-450b-5p mimic+recombination protein Nrf2, as well as the decreased expression levels of intracellular ROS and iNOS.
transcription factor target	36125462	hsa-mir-33a	Triple Negative Breast Neoplasms	RESULTS: We found the vaspin level was positively correlated with BMI in breast malignant patients and vaspin could significantly enhance the proliferation, infiltration and transferring of triple-negative breast cancer cells by restraining the expression of miR-33a-5p. CONCLUSION: Vaspin, as a cancer-promoting cytokine, may inhibit miR-33a-5p thus increasing the level of ABHD2 to promote the development of the triple-negative breast cancer.
circulation_biomarker_diagnosis_ns	36125433	hsa-mir-21	Carcinoma, Renal Cell	Treating human umbilical vein endothelial cells (HUVEC) with the plasma of patients with hypertensive ccRCC and miR5p, elevated in the plasma of patients with hypertensive ccRCC, reduced the expression of TIMP3 compared with normotensive and control littermates.
circulation_biomarker_diagnosis_ns	36125433	hsa-mir-21	Hypertension	Treating human umbilical vein endothelial cells (HUVEC) with the plasma of patients with hypertensive ccRCC and miR5p, elevated in the plasma of patients with hypertensive ccRCC, reduced the expression of TIMP3 compared with normotensive and control littermates.
genetics_knock down_promote	36125241	hsa-mir-7	Prostatic Neoplasms	5p mimics or inhibitor and/or overexpression vector (EGFR) or small interfering RNA of EGFR (si-EGFR) or its control, and found that overexpression of RHPN1-AS1 inhibited miR
other	36125106	hsa-mir-155	Liver Neoplasms	MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma.
other	36125106	hsa-mir-155	Lung Neoplasms	MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma.
other	36125106	hsa-mir-155	Lymphoma	MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma.
other	36125080	hsa-mir-200c	Craniofacial Abnormalities	Conclusion: CaCO(3) nanoparticles enhance miR-200c delivery to accelerate alveolar bone formation, thereby demonstrating the application of CaCO(3)/miR-200c to craniofacial bone defects.
circulation_biomarker_diagnosis_ns	36125080	hsa-mir-200c	Alveolar Bone Loss	This work aimed to enhance transfection efficiency and miR-200c-induced bone formation in alveolar bone defects via plasmid DNA encoding miR-200c delivery from CaCO(3) nanoparticles. CaCO(3)/miR-200c treatment in vivo significantly increased bone formation in rat alveolar bone defects.
circRNA target	36125054	hsa-mir-944	Carcinoma, Hepatocellular	Additionally, miR-944 was proved to directly target MAD2L1 in HCC cells.
other	36125044	hsa-mir-1a	Cardiomegaly	Previous studies have found microRNA-1 (miR-1) and hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) may be involved in the pathogenesis of thyroid hormone (TH) induced cardiac hypertrophy.
other	36125044	hsa-mir-1	Cardiomegaly	Previous studies have found microRNA-1 (miR-1) and hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) may be involved in the pathogenesis of thyroid hormone (TH) induced cardiac hypertrophy.
exosome	36123601	hsa-mir-1	Pre-Eclampsia	CONCLUSION: We believe that exosome-derived miR
lncRNA target	36123344	hsa-mir-940	Breast Neoplasms	3p/KLLN axis, and suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
lncRNA target	36122770	hsa-mir-362	Neuralgia	Overall, Miat upregulated BAMBI by inhibiting miR3p, thereby promoting the occurrence and development of NP.
circulation_biomarker_diagnosis_ns	36122657	hsa-mir-4726	Coronary Disease	5p on blood pressure.
lncRNA target	36121635	hsa-mir-188	Cholangiocarcinoma	5p to up-regulate mRNA translation and protein expression of PSMD10, thereby facilitating cholangiocarcinoma cell invasion and migration and inhibiting its apoptosis.
lncRNA target	36121621	hsa-mir-29	Cardiomyopathies	Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years.
lncRNA target	36121621	hsa-let-7	Cardiomyopathies	Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years.
lncRNA target	36121621	hsa-mir-92a	Cardiomyopathies	Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years.
lncRNA target	36121621	hsa-mir-27	Cardiomyopathies	Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years.
lncRNA target	36121621	hsa-mir-130	Cardiomyopathies	Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years.
circulation_biomarker_diagnosis_up	36121133	hsa-mir-155	Breast Neoplasms	Studies have consistently noted an increase in miR155 levels in serum and/or tissues in patients with BrCa.
circulation_biomarker_diagnosis_ns	36121076	hsa-mir-29c	Nasopharyngeal Carcinoma	Furthermore, the validation of hsa-miR-29c-3p expression on plasma NPC with known tumor vs.
transcription factor target	36121042	hsa-mir-144	Endometrial Hyperplasia	Taken together, these evidences suggested that miR-144 may act as a promising therapeutic target for arterial restenosis.
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-652	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-652	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-27a	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-27a	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-223	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-20b	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-20b	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-451	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-451	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-223	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-148a	Gastrointestinal Neoplasms	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
circulation_biomarker_diagnosis_ns	36120988	hsa-mir-148a	Inflammatory Bowel Diseases	RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%).
lncRNA target	36120949	hsa-let-7f-1	Wounds and Injuries	In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing.
lncRNA target	36120949	hsa-let-7f	Wounds and Injuries	In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing.
lncRNA target	36120949	hsa-let-7f	Autoimmune Lymphoproliferative Syndrome	In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing.
lncRNA target	36120949	hsa-let-7f-1	Autoimmune Lymphoproliferative Syndrome	In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing.
target gene	36120905	hsa-mir-200a	Lung Neoplasms	Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis.
genetics_overexpression_promote	36120594	hsa-mir-342	Leukemia, Myeloid, Acute	Overexpressing or knocking down SOX12 reversed miR
other	36120583	hsa-mir-20a	Urinary Bladder Neoplasms	We also identified an lncRNA SNHG14/miR-20a-5p/CASP8 regulatory axis in bladder cancer by constructing a ceRNA network.
transcription factor target	36120434	hsa-mir-33a	Ovarian Neoplasms	In addition, miR-33a-5p bound directly to the 3'UTR of CROT to negatively regulate the expression of CROT and promoted OC cell growth. Thus, targeting the miR-33a-5p/CROT axis may have clinical potential for the treatment of patients with OC.
other	36120427	hsa-mir-195	Diabetes Mellitus, Type 2	The opposite occurred for miR5p in subcutaneous AT.
lncRNA target	36120375	hsa-mir-570	Diabetes Mellitus	3p in diabetic vascular endothelium, and the potential molecular mechanism of vaccarin regulating endothelial inflammatory injury through miR
exosome	36119841	hsa-mir-6068	Prostatic Neoplasms	We aimed to determine the levels of small extracellular vesicle (sEV)-associated microRNAs (miRs); miR-4737, miR-6068, and miR-6076 in a large panel of PCa cells and delineate the biological significance of miR-6068 in promoting PCa cells.
genetics_overexpression_promote	36119773	hsa-mir-761	Carcinoma, Hepatocellular	Our previous study showed that microRNA-761 (miR-761) is overexpressed in hepatocellular carcinoma (HCC) tissues and that its inhibition affects mitochondrial function and inhibits HCC metastasis.
circulation_biomarker_diagnosis_up	36119459	hsa-mir-129	Leukemia, Myeloid, Acute	CircEHBP1 was detected in both nuclear and cytoplasm fractions of AML cells and directly interacted with premature miR-129.
circulation_biomarker_diagnosis_ns	36118948	hsa-mir-142	Thyroid Neoplasms	This work aims to explore the risk factors of lung metastasis (LM) in differentiated thyroid cancer (DTC) (LM-DTC) and the effect of treatment and to detect the relationship between LM-DTC and the levels of matrix metalloproteinase-13 (MMP-13) and micro ribonucleic acid (RNA)-142 (miR-142) in peripheral blood. Follicular carcinoma, abnormal expressions of MMP-13, and miR-142 can increase the risk of LM-DTC.
other	36118829	hsa-mir-17	Varicose Veins	5p, miR-1297, miR-20b-5p, and miR-33a-3p.
other	36118829	hsa-mir-20b	Varicose Veins	5p, miR-1297, miR-20b-5p, and miR-33a-3p.
other	36118829	hsa-mir-33a	Varicose Veins	5p, miR-1297, miR-20b-5p, and miR-33a-3p.
other	36118829	hsa-mir-1297	Varicose Veins	5p, miR-1297, miR-20b-5p, and miR-33a-3p.
other	36118829	hsa-mir-129	Varicose Veins	5p, miR-1297, miR-20b-5p, and miR-33a-3p.
genetics_overexpression_promote	36118827	hsa-mir-1306	Leukemia, Myeloid, Acute	5p and overexpressed miR
lncRNA target	36118276	hsa-mir-150	Nasopharyngeal Carcinoma	The clinical significance and potential targets of miR
transcription factor target	36118085	hsa-mir-29a-1	Acute Lung Injury	5p may be a novel therapeutic strategy for preventing ALI.
transcription factor target	36118085	hsa-mir-29a-1	Pulmonary Fibrosis	5p may be a novel therapeutic strategy for preventing ALI.
lncRNA target	36117461	hsa-mir-214	Glioma	3p inhibits TMZ resistance in glioma by promoting CPLX2.
circulation_biomarker_diagnosis_ns	36117315	hsa-mir-132	Epilepsy	RESULTS: In the serum of epileptic patients, the level of lncRNA UCA1 and ATG16L1 was reduced and miR
lncRNA target	36116139	hsa-mir-210	Colorectal Neoplasms	CONCLUSION: Direct application of the PMIS-miR-210 inhibitor to growing tumours may be an effective colorectal cancer therapeutic.
genetics_knock down_promote	36116109	hsa-mir-532	Femur Head Necrosis	In addition, in vivo experiments also confirmed that knockdown of miR
lncRNA target	36115716	hsa-mir-373	Glioblastoma	We further found that miR-373 and miR-520s expression was negatively associated with CD44 expression in GBM specimens, and that the miR-373 or miR-520s-CD44 interaction network significantly affected the growth and invasiveness of GBM cells. CONCLUSION: The miR-373 and miR-520s exert their functions by suppressing CD44 expression in GBM cells, and their expression, together with that of CD44, could thus serve as a valuable biomarker of GBM prognosis.
lncRNA target	36115716	hsa-mir-520	Glioblastoma	We further found that miR-373 and miR-520s expression was negatively associated with CD44 expression in GBM specimens, and that the miR-373 or miR-520s-CD44 interaction network significantly affected the growth and invasiveness of GBM cells. CONCLUSION: The miR-373 and miR-520s exert their functions by suppressing CD44 expression in GBM cells, and their expression, together with that of CD44, could thus serve as a valuable biomarker of GBM prognosis.
other	36115656	hsa-mir-20	Head and Neck Neoplasms	The nanoparticles displayed the pH-responsive release and uptake of Oxa and miR-320 into human tongue squamous carcinoma SAS cells.
exosome	36115547	hsa-mir-506	Adenocarcinoma of Lung	Collectively, our findings revealed that exosomal miR-506 sensitized LUAD cells to CDDP-based HT by inhibiting ATAD2/PI3K/AKT signaling pathway, offering a potential therapeutic target for LUAD treatment.
transcription factor target	36114946	hsa-mir-24	pancreatic adenocarcinoma	Our data suggest that targeting ASF1B/miR
genetics_overexpression_promote	36114826	hsa-mir-648	Cholangiocarcinoma	SKI protein expression was decreased in human CC cells overexpressing miRNA-3648, endogenous SKI protein expression was decreased in human CC tumor tissues, and endogenous SKI mRNA expression was suppressed in human CC cells characterized by rapid growth.
lncRNA target	36114673	hsa-mir-29	Diabetes Mellitus	Augmenting physiologic NPGPx expression via experimentally induced miR-29 suppression, using cutaneous tissue nanotransfection or targeted lipid nanoparticle delivery of anti-sense oligonucleotides, proved to be sufficient to overcome the deleterious effects of diabetes on this specific pathway to enhance tissue repair.
other	36114541	hsa-mir-711	Diabetes Mellitus	OBJECTIVE: To investigate the regulation of adiponectin/miR-711 on TLR4/NF-kappaB-mediated inflammatory response and diabetic cardiomyocyte apoptosis. Adiponectin/miR-711 reduced myocardial inflammation and apoptosis in diabetic rats.
circRNA target	36114444	hsa-mir-449c	Glioblastoma	Furthermore, circGLIS3 positively regulated CAPG and GLIS3 by sponging miR-449c-5p to affect GBM cell proliferation and apoptosis. CONCLUSIONS: In summary, our study identified that circGLIS3 could promote proliferation and inhibit apoptosis of GBM cells via targeting miR-449c-5p/GLIS3/CAPG axis in vitro.
other	36114410	hsa-mir-570	Breast Neoplasms	In accordance with this hypothesis, we determined a significant role for miR-570 in regulating markers of mammary tumor progression, including cell motility and invasion.
circulation_biomarker_diagnosis_ns	36114255	hsa-mir-29a	Alzheimer Disease	Some plasma miRNAs (miRNA-92a-3p, miRNA5p, miRNA-29a-3p) are slightly dysregulated in AD, being potential biomarkers of the pathology.
transcription factor target	36114225	hsa-mir-455	Osteoarthritis	In addition, We found that EVs derived from TGFbeta3-preconditioned BMSCs rich in miR-455 promoted OA alleviation and cartilage regeneration by activating the SOX11/FOXO signaling pathway.
other	36112753	hsa-mir-155	Hemophilia A	MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1).
other	36112753	hsa-mir-155	Atherosclerosis	MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1).
other	36112753	hsa-mir-197	Hemophilia A	MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1).
other	36112753	hsa-mir-197	Atherosclerosis	MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1).
circulation_biomarker_diagnosis_ns	36112335	hsa-mir-195	Breast Neoplasms	In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155).
circulation_biomarker_diagnosis_ns	36112335	hsa-mir-155	Breast Neoplasms	In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155).
circulation_biomarker_diagnosis_ns	36112335	hsa-mir-21	Breast Neoplasms	In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155).
other	36112264	hsa-mir-150	Osteoporosis, Diabetic	5p promotes the osteogenesis of DO rats.
other	36111973	hsa-mir-132	Status Epilepticus	"Our previous study found that pro-inflammatory cytokines and miR3p (hereinafter referred to as ""miR-132"") expression were upregulated, but how miR-132 affected reactive astrocyte polarization and neuronal damage during epilepsy is not fully understood."
other	36111973	hsa-mir-132	Parkinson Disease	"Our previous study found that pro-inflammatory cytokines and miR3p (hereinafter referred to as ""miR-132"") expression were upregulated, but how miR-132 affected reactive astrocyte polarization and neuronal damage during epilepsy is not fully understood."
other	36111932	hsa-mir-16	Inflammatory Bowel Diseases	MiR-16 could serve as a potential biomarker to assess inflammation.
transcription factor target	36111920	hsa-mir-181d	Duane Retraction Syndrome	OBJECTIVE: Previous studies show the downregulation of miR-181d-5p in the vitreous humor of patients with diabetic retinopathy (DR); however, it is not known whether miR-181d-5p is implicated in the development of DR. CONCLUSIONS: These findings indicate that miR-181d-5p ameliorates HG-stimulated proliferation, migration and angiogenesis of hRMECs through inhibition of VEGFA, which might provide a new target for the treatment of DR.
other	36111920	hsa-mir-181d	Diabetic Retinopathy	OBJECTIVE: Previous studies show the downregulation of miR-181d-5p in the vitreous humor of patients with diabetic retinopathy (DR); however, it is not known whether miR-181d-5p is implicated in the development of DR.
other	36111773	hsa-mir-1827	Intervertebral Disc Degeneration	Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD.
other	36111773	hsa-mir-4534	Intervertebral Disc Degeneration	Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD.
other	36111773	hsa-mir-185	Intervertebral Disc Degeneration	Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD.
transcription factor target	36111745	hsa-mir-212	Liver Injury	Collectively, these findings define a novel mechanism for activating M (3)R to reverse liver injury, which affects hepatocyte proliferation through the Sp1/Gm 2199/miR-212/ERK axis.
genetics_overexpression_suppress	36111570	hsa-mir-513a	Leukemia, Myeloid	The overexpression of miR-513a-5p inhibited the gene expression level of CASP8 in a human myeloid leukemia cell model (75% change) and the level of a 43-kD fragment of CASP8 protein (P</=0.01).
genetics_knock down_promote	36111503	hsa-mir-33a	Esophageal Squamous Cell Carcinoma	In conclusion, this study indicates that CASC15 was upregulated in ESCC and CASC15 knockdown hindered ESCC progression through targeting the miR-33a-5p/PTGS2 axis.
other	36111489	hsa-mir-199a	Colorectal Neoplasms	The SLITRK6 gene and its regulatory miRNA miR199a3p are promising for further validation in functional studies to deepen the present understanding of the regulation of CSCrelated genes in CRC.
other	36111489	hsa-mir-1233	Colorectal Neoplasms	All investigated miRNAs were significantly differentially expressed in lymph node metastasis, and miR199a3p, miR4255p and miR12333p in liver metastasis.
other	36111489	hsa-mir-425	Colorectal Neoplasms	All investigated miRNAs were significantly differentially expressed in lymph node metastasis, and miR199a3p, miR4255p and miR12333p in liver metastasis.
transcription factor target	36111260	hsa-mir-22	Carcinoma, Non-Small-Cell Lung	5p downregulation contributed to the malignant progression of NSCLC by targeting TWIST2.
other	36111133	hsa-mir-129	Rotator Cuff Injuries	Based on the topological properties of the largest module, we identified several important ncRNAs including hsa_circ_0000722, hsa-miR5p and hsa-miR-30c-5p, whose interacting mRNAs related to muscle diseases, fat and inflammation.
target gene	36111048	hsa-mir-195	Gallbladder Neoplasms	MiR-195-5p suppresses the proliferation, migration, and invasion of gallbladder cancer cells by targeting FOSL1 and regulating the Wnt/beta-catenin pathway.
transcription factor target	36110849	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	One prominent miRNA family in the latter setting is the miR-15 family, consisting of the three clusters miR-15a/16-1, miR-15b/16-2 and miR-497/195, which is best known for its prominent tumor suppressive role in chronic lymphocytic leukemia (CLL).
transcription factor target	36110849	hsa-mir-15	Leukemia, Lymphocytic, Chronic, B-Cell	One prominent miRNA family in the latter setting is the miR-15 family, consisting of the three clusters miR-15a/16-1, miR-15b/16-2 and miR-497/195, which is best known for its prominent tumor suppressive role in chronic lymphocytic leukemia (CLL).
transcription factor target	36110849	hsa-mir-15b	Leukemia, Lymphocytic, Chronic, B-Cell	One prominent miRNA family in the latter setting is the miR-15 family, consisting of the three clusters miR-15a/16-1, miR-15b/16-2 and miR-497/195, which is best known for its prominent tumor suppressive role in chronic lymphocytic leukemia (CLL).
other	36110528	hsa-mir-1	Adenocarcinoma of Lung	Lastly, we constructed the lncRNA UCA1/miR3p/DLD axis that may play a key role in the progression of LUAD and screened nine active components of traditional Chinese medicine (TCM) that may regulate DLD.
target gene	36110154	hsa-mir-106b	Uterine Cervical Neoplasms	MicroRNA-106b-5p (miR-106b-5p) suppresses the proliferation and metastasis of cervical cancer cells via down-regulating fibroblast growth factor 4 (FGF4) expression.
circRNA target	36109751	hsa-mir-28	Triple Negative Breast Neoplasms	Rescue experiments presented that circ-CSNK1G1 played functions by targeting miR
genetics_overexpression_promote	36109749	hsa-mir-1244	Osteosarcoma	MiR-1244 overexpression suppressed the malignant behaviors of OS cells.
lncRNA target	36109176	hsa-mir-150	Fetal Alcohol Spectrum Disorders	5p inhibition of Vezf1 may adversely alter the development of the cortical microvasculature during PAE and contribute to deficits seen in patients with FASD.
lncRNA target	36109176	hsa-mir-150	Acrodermatitis enteropathica	5p inhibition of Vezf1 may adversely alter the development of the cortical microvasculature during PAE and contribute to deficits seen in patients with FASD.
circulation_biomarker_diagnosis_ns	36109098	hsa-mir-125a	Ischemic Stroke	CONCLUSIONS: These findings demonstrate that circulating EMVs and EMV-miR-125a-5p are closely related with the occurrence, progress, subtypes and severity of IS, and they can serve as innovative biomarkers and therapeutic targets for IS, especially when they are combined.
lncRNA target	36107024	hsa-mir-451	Breast Neoplasms	This study aims to investigate the effect of 7-O-geranylquercetin (GQ) combining microRNA-451(miR-451) on reversing drug resistance of breast cancer and reveal the mechanism related to P-gp. These results suggest that GQ and miR-451 have synergistic effect on reversing drug resistance through reducing the expression of MDR1 and P-gp in breast cancer MCF-7/ADR cells.
genetics_knock down_promote	36106650	hsa-mir-30	Colorectal Neoplasms	Loss-of-function experiments revealed that inhibition of circ-CD44 suppressed proliferation, migration, and invasion while it increased OXA sensitivity and apoptosis in OXA-resistant colorectal cancer cells, which was overturned by suppression of miR
lncRNA target	36106122	hsa-let-7e	Glioma	Moreover, GAS5 played an anti-oncogenic role in GBM through the combined involvement of let-7e and miR-125a in vivo and in vitro.
lncRNA target	36106122	hsa-mir-125a	Glioma	Moreover, GAS5 played an anti-oncogenic role in GBM through the combined involvement of let-7e and miR-125a in vivo and in vitro.
other	36105715	hsa-mir-144	Pancreatic Carcinoma	3p/COL10A1 axis was identified as the most likely upstream noncoding RNA pathway for COL10A1 in pancreatic cancer.
transcription factor target	36105681	hsa-mir-559	Carcinoma, Hepatocellular	These results reveal the interaction between miR-559 and PARD3 in HCC cells and provide new insights into their potential targets as therapeutic treatment against HCC.
exosome	36105616	hsa-mir-138	Pathological Scars	CONCLUSION: Exosomes derived from MSCs acting as a delivery vehicle to deliver miR
lncRNA target	36105448	hsa-mir-21	Uterine Cervical Neoplasms	Research has proved that miR-21 is associated with the invasion and metastasis of cervical cancer, and its specific mechanism has not been completely clear; EMT exerts a significant effect on the invasion and metastasis of epithelial malignant tumors; we speculate whether miR-21 regulates the EMT process of cervical cancer cells. ELISA and RT-PCR studied HPV-induced cervical cancer cells, and it was found that HPV may induce miR-21 to pass through the TGF beta R2/hTERC pathway which promotes epithelial stromal transformation and tumor progression of cervical cancer cells.
other	36105099	hsa-mir-22	Coronary Artery Disease	3p as a specific biomarker for diagnosing CAD.
target gene	36105009	hsa-mir-22	Breast Neoplasms	LncRNA MIR4435-2HG promotes proliferation, migration, invasion and epithelial mesenchymal transition via targeting miR-22-3p/TMEM9B in breast cancer.
lncRNA target	36104825	hsa-mir-378a	Stomach Neoplasms	Subsequently, H19 and miR-378a-5p were identified as upstream regulatory ncRNAs that could potentially bind SERPINH1 in GC. CONCLUSIONS: H19 may regulate the immune cell infiltration in carcinogenesis of GC through miR-378a-5p/SERPINH1 signaling.
genetics_overexpression_promote	36104590	hsa-mir-429	Carcinoma, Non-Small-Cell Lung	Overexpression of circLIFR could suppress NSCLC progress by acting as a sponge of miR-429 to regulate the expression of CELF2 and PTEN/AKT-signaling pathways in NSCLC.
other	36104322	hsa-mir-16	Stomach Neoplasms	5p level was decreased.
other	36104170	hsa-mir-192	Colorectal Neoplasms	In conclusion, AP3M2, DAPK1, ISYNA1, PPM1K, PRR4, RNF122, CCL26 and hsa-miR5p appear to be related to the progression of colorectal cancer.
lncRNA target	36103723	hsa-mir-181a	Multiple Sclerosis	In silico analyses showed that hsa-miR-181a-5p may participate in MS pathology by targeting MAP2K1, CREB1, ATXN1, and ATXN3 genes in inflammation and neurodegeneration pathways. The circulatory hsa-miR-181a-5p can regulate target genes, reversing the mechanisms involved in MS pathologies such as protein uptake and processing, cell proliferation and survival, inflammation, and neurodegeneration.
other	36103723	hsa-mir-125b	Multiple Sclerosis	5p, hsa-miR-181a-5p, and hsa-miR-125b-5p) was investigated in 69 individuals, including 39 MS patients (relapsing-remitting MS (RRMS), n = 27; secondary progressive MS (SPMS), n = 12) and 30 healthy controls.
other	36103723	hsa-mir-9	Multiple Sclerosis	5p, hsa-miR-181a-5p, and hsa-miR-125b-5p) was investigated in 69 individuals, including 39 MS patients (relapsing-remitting MS (RRMS), n = 27; secondary progressive MS (SPMS), n = 12) and 30 healthy controls.
other	36103723	hsa-mir-155	Multiple Sclerosis	5p, hsa-miR-181a-5p, and hsa-miR-125b-5p) was investigated in 69 individuals, including 39 MS patients (relapsing-remitting MS (RRMS), n = 27; secondary progressive MS (SPMS), n = 12) and 30 healthy controls.
genetics_knock down_promote	36103059	hsa-mir-942	Adenocarcinoma of Lung	5p knockdown in lung adenocarcinoma cells.
lncRNA target	36103025	hsa-mir-497	Uterine Cervical Neoplasms	Besides, MAPK1 expression in CC cells was detected via Western blot after LINC00511 and miR
other	36103016	hsa-mir-204	Thyroid Neoplasms	3p could be used as a diagnostic and prognostic tool for personalizing the treatment of thyroid cancer patients.
other	36103016	hsa-mir-222	Thyroid Neoplasms	3p could be used as a diagnostic and prognostic tool for personalizing the treatment of thyroid cancer patients.
other	36103016	hsa-mir-203a	Thyroid Neoplasms	3p levels were determined in 99 cases of thyroid neoplasias (77 papillary thyroid carcinomas (PTC) of diverse variants, 12 follicular thyroid adenomas (FTA) and 10 nodular goiters (NG)) along with 99 adjacent non-malignant thyroid tissues using quantitative RT-PCR.
other	36102801	hsa-mir-276	Fragile X Syndrome	Together, our findings support a model in which FMRP facilitates miR-276a-mediated control of nejire for proper dendrite space-filling morphology and shed light on microRNA-dependent dendrite developmental pathology of fragile X syndrome.
other	36102801	hsa-mir-276a	Fragile X Syndrome	Together, our findings support a model in which FMRP facilitates miR-276a-mediated control of nejire for proper dendrite space-filling morphology and shed light on microRNA-dependent dendrite developmental pathology of fragile X syndrome.
other	36102571	hsa-mir-218	Encephalocele	An in vivo calvarial defect model showed that the PPP-RGI/miRloaded microspheres significantly enhanced bone tissue regeneration.
other	36102304	hsa-mir-663	Sepsis	Collectively, the results determined that miR36633p may be a potentially powerful diagnostic and predictive biomarker of sepsis and that the combined and simultaneous detection of several biomarkers, including proteins, miRNAs and mRNA may be a reliable approach for the fast diagnosis and early identification of sepsis.
circulation_biomarker_diagnosis_ns	36101791	hsa-mir-515	Pulmonary Disease, Chronic Obstructive	5p expression was decreased in the serum of smokers compared to non-smokers and further reduced in the serum of COPD.
other	36101742	hsa-mir-5571	Adenocarcinoma of Lung	5p, the better survival of LUAD OS is, and these two miRNA expressions contribute the most to the model.
other	36101742	hsa-mir-195	Adenocarcinoma of Lung	3p/RAB1A/TM9SF3 regulatory axis, which may also play an important role in the progression of LUAD.
other	36101507	hsa-mir-160a	Anemia, Hypochromic	Here, we demonstrate that miR160a positively regulates broad-spectrum resistance against the causative agents of blast, leaf blight and sheath blight in rice.
other	36101507	hsa-mir-160a	Sepsis	Here, we demonstrate that miR160a positively regulates broad-spectrum resistance against the causative agents of blast, leaf blight and sheath blight in rice.
transcription factor target	36101427	hsa-mir-33a	Adenocarcinoma of Lung	At the same time, the expression of eight target miRNAs of MNDA was significantly up-regulated, and the expression of hsa-miR-33a-5p and hsa-miR-33b-5p were verified to directly target MNDA.
other	36101384	hsa-mir-2682	Colonic Neoplasms	3-5p.
other	36101384	hsa-mir-1277	Colonic Neoplasms	3-5p.
other	36101384	hsa-mir-509	Colonic Neoplasms	3-5p.
other	36100919	hsa-mir-92a	Breast Neoplasms	CONCLUSION: Collectively, our results uncovered the miR-92a-3p/KLF2/BIRC5 axis in breast cancer and provided a potential mechanism for breast cancer development, which may serve as promising strategies for breast cancer therapy.
genetics_overexpression_promote	36099512	hsa-mir-20a	Lung Neoplasms	Immunohistochemistry and Western blotting studies show that PDL1 is overexpressed in the advanced stages rather than in initial lung cancer because the expression of miRNA320a is overexpressed in initial stages but restricted in advanced stages of lung cancer.
circulation_biomarker_diagnosis_ns	36099375	hsa-mir-146a	Tuberculosis, Pulmonary	METHODOLOGY: We investigated the level of expression of miRNA-146a using an RT-qPCR technique in peripheral blood mononuclear cells of 44 patients with active pulmonary TB and 17 healthy individuals. CONCLUSIONS: Our results indicate that miRNA-146a plays a significant role in the pathogenesis of TB, suggesting that miRNA-146a could be used as a biomarker for active pulmonary TB.
other	36098711	hsa-mir-181a	Osteosarcoma	Our findings highlight new insights into understanding the role of miR-181a in the pathogenesis of osteosarcoma.
circRNA target	36098705	hsa-mir-1238	Carcinoma, Non-Small-Cell Lung	Studies revealed that circKIF4A sponged miR-1238 to promote NSCLC progression by up-regulating claudin14 (CLDN14) expression. In conclusion, circKIF4A is a potential diagnostic and therapeutic target in the circKIF4A/miR-1238/CLDN14 axis that plays an important role in NSCLC progression.
genetics_knock down_promote	36098468	hsa-mir-494	Urinary Bladder Neoplasms	3p knockdown on the proliferation, migration, and invasion of BC cells.
other	36098178	hsa-mir-128	Myocardial Reperfusion Injury	The results showed that the FOXD3-AS1 and TXNIP were highly expressed, whereas miR-128 was expressed at low levels in I/R myocardial tissues and H/R-induced H9c2 cells.
lncRNA target	36098040	hsa-mir-885	Thyroid Cancer, Papillary	CONCLUSION: Our data elucidated that circPTPRM may play an oncogenic role in PTC through circPTPRM/miR
lncRNA target	36097836	hsa-mir-214	Myocardial Reperfusion Injury	CONCLUSIONS: CircZNF609 aggravated the progression of MIRI via targeting miR3p/PTGS2 axis, which suggested CircZNF609 might act as a vital modulator in MIRI.
lncRNA target	36097778	hsa-mir-194	Epilepsy	CONCLUSIONS: The 2-DG might play an anti-epilepsy effect by up-regulating K(ATP) channel subunits Kir6.1 and Kir6.2via miR-194.
other	36097539	hsa-mir-148a	Squamous Cell Carcinoma of Head and Neck	Within the ceRNA network, FOXP3, IL10RA, STAT5A, PRF1, IL2RA, miR-148a-3p, miR3p, and lncRNAs, including CXCR2P1, HNRNPA1P21, CTA-384D8.36, and IGHV1OR15-2, were closely correlated with the OS of HNSCC patients.
other	36097539	hsa-mir-3065	Squamous Cell Carcinoma of Head and Neck	Within the ceRNA network, FOXP3, IL10RA, STAT5A, PRF1, IL2RA, miR-148a-3p, miR3p, and lncRNAs, including CXCR2P1, HNRNPA1P21, CTA-384D8.36, and IGHV1OR15-2, were closely correlated with the OS of HNSCC patients.
other	36097106	hsa-mir-122	Liver Failure	Liver enzymes, MicroRNA-122 values as well as necrotic score were significantly lower in the LF-SM and LF-MSC-CM groups compared to sham.
other	36096786	hsa-mir-196b	Pre-Eclampsia	RESULTS: We initially identified five PE-associated differentially expressed miRNAs from miRNA sequencing data and subsequently validated two miRNAs (miR-196b-5p and miR5p) as robust biomarkers by association analysis with clinical characteristics and qRT-PCR in tissue specimens in the discovery phase.
other	36096386	hsa-mir-125a	Glioma	We studied Trx-1, TrxR-1, and PRDX-1 messenger RNA expression levels by quantitative real-time polymerase chain reaction and protein levels by Western blot and miR-23a, miR-23b, miR-125a, miR-21, and let-7a miRNA expression levels by quantitative real-time polymerase chain reaction in 16 glioma, 15 meningioma, 5 metastatic, and 2 benign tumor samples.
lncRNA target	36096386	hsa-mir-23a	Glioma	METHODS: In this study, we aimed to determine the expression profiles of redox components Trx-1, TrxR-1 and PRDX-1, and oncogenic miR-21, miR-23a/b and let-7a and oncosuppressor miR-125 in different brain tumor tissues and their association with increasing tumor grade.
lncRNA target	36096386	hsa-mir-23b	Glioma	METHODS: In this study, we aimed to determine the expression profiles of redox components Trx-1, TrxR-1 and PRDX-1, and oncogenic miR-21, miR-23a/b and let-7a and oncosuppressor miR-125 in different brain tumor tissues and their association with increasing tumor grade.
lncRNA target	36096386	hsa-mir-21	Glioma	METHODS: In this study, we aimed to determine the expression profiles of redox components Trx-1, TrxR-1 and PRDX-1, and oncogenic miR-21, miR-23a/b and let-7a and oncosuppressor miR-125 in different brain tumor tissues and their association with increasing tumor grade.
lncRNA target	36096386	hsa-let-7a	Glioma	METHODS: In this study, we aimed to determine the expression profiles of redox components Trx-1, TrxR-1 and PRDX-1, and oncogenic miR-21, miR-23a/b and let-7a and oncosuppressor miR-125 in different brain tumor tissues and their association with increasing tumor grade.
circulation_biomarker_diagnosis_ns	36096296	hsa-mir-148b	Metabolic Associated Fatty Liver  Disease 	5p, and hsa-miR-148b-3p with plasma levels of CK-18 in patients with simple steatosis compared with patients without the disease.
circulation_biomarker_diagnosis_ns	36096296	hsa-mir-122	Metabolic Associated Fatty Liver  Disease 	5p, and hsa-miR-148b-3p with plasma levels of CK-18 in patients with simple steatosis compared with patients without the disease.
circulation_biomarker_diagnosis_ns	36096296	hsa-mir-140	Metabolic Associated Fatty Liver  Disease 	5p, and hsa-miR-148b-3p with plasma levels of CK-18 in patients with simple steatosis compared with patients without the disease.
lncRNA target	36096257	hsa-mir-146a	Inflammation	miR-146a-5p may represent a promising biomarker for inflammatory disorders, and may provide an effective therapeutic method to alleviate weaning stress in piglets and some experimental basis to improve the intestinal health of livestock.
genetics_GWAS	36096162	hsa-mir-525	Ovarian Diseases	RAI14) that might play epigenetic roles in hypoxia-induced reproductive impairment.
genetics_overexpression_promote	36094613	hsa-mir-182	Glioma	5p reversed the inhibitory effects on proliferative and metastatic abilities of glioma cells with LINC01018 overexpression.
genetics_knock down_promote	36094501	hsa-mir-876	Leukemia, Myeloid, Acute	CONCLUSION: CircNFIX knockdown could suppress the proliferation and induce the apoptosis of AML cells by targeting the miR
transcription factor target	36093844	hsa-mir-195	Stomach Neoplasms	5p restrained migration, proliferation, invasion and epithelial-mesenchymal transition process of GAC cells, and promoted cell apoptosis through regulating OTX1.
lncRNA target	36093813	hsa-mir-223	Non-alcoholic Fatty Liver Disease	3p and subsequent E2F1 suppression, which may suggest miR
target gene	36093807	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	MiRNA-16-1 Suppresses Mcl-1 and Bcl-2 and Sensitizes Chronic Lymphocytic Leukemia Cells to BH3 Mimetic ABT-199.
circulation_biomarker_diagnosis_up	36093435	hsa-mir-29	Colorectal Neoplasms	After exosomes were cocultured with colorectal cancer tumor circulating T84 cells, the expression of Netrin-1 and CD146 was upregulated, the expression of miR3p was downregulated, the proliferation and migration ability of T84 cells were enhanced, and EMT occurred.
other	36093145	hsa-mir-126	Death, Sudden, Cardiac	5p and miR-499a-5p presented good diagnostic abilities for CAD-SCD, and their combination could help evaluate CAD condition.
other	36093145	hsa-mir-499a	Death, Sudden, Cardiac	5p and miR-499a-5p presented good diagnostic abilities for CAD-SCD, and their combination could help evaluate CAD condition.
transcription factor target	36092931	hsa-mir-579	Coronavirus Infections	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-664b	Severe Acute Respiratory Syndrome	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-1283	Coronavirus Infections	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-664b	Benign Paroxysmal Positional Vertigo	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-579	Benign Paroxysmal Positional Vertigo	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-664b	Coronavirus Infections	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-1283	Benign Paroxysmal Positional Vertigo	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-579	Severe Acute Respiratory Syndrome	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
transcription factor target	36092931	hsa-mir-1283	Severe Acute Respiratory Syndrome	In all, we found 27 miRNAs that target RdRp mRNA sequence of multiple coronaviruses, of which three - hsa-miR-1283, hsa-miR3p, and hsa-miR-664b-3p target BCoV, SARS-CoV and SARS-CoV-2.
other	36092922	hsa-mir-580	Squamous Cell Carcinoma of Head and Neck	The CircPUM1/mir-580/STAT3 axis has a certain effect on the radiosensitivity of OSCC.
genetics_knock down_suppress	36092909	hsa-mir-665	Osteoarthritis	Circ_0037658 and ADAMTS5 levels were increased, and miR-665 was decreased in OA cartilage samples and IL-1beta-treated chondrocyte cells. Conclusion: Circ_0037658 knockdown relieved IL-1beta-triggered chondrocyte injury via regulating the miR-665/ADAMTS5 axis, promising an underlying therapeutic strategy for OA.
other	36092901	hsa-mir-378a	Stomach Neoplasms	We found that SNHG10 and CAMK2N1 were highly expressed in gastric cancer lines, and the miR-378a-3p was lowly expressed in BGC-823, HGC-27, and MKN-45.
other	36092798	hsa-mir-423	Diabetes Mellitus	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
other	36092798	hsa-mir-199b	Alzheimer Disease	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
other	36092798	hsa-mir-423	Alzheimer Disease	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
other	36092798	hsa-mir-199a	Diabetes Mellitus	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
other	36092798	hsa-mir-199a	Alzheimer Disease	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
other	36092798	hsa-mir-199b	Diabetes Mellitus	5p, the four most significant miRNAs, as well as NEAT1, XIST, and KCNQ1OT1, the three most important lncRNAs, and their interacting proteins in the final tripartite network, have been proposed as new candidate biomarkers in the cross-talk between DM and AD.
transcription factor target	36092502	hsa-mir-146a	Emphysema	Notably, several miRNAs, such as hsa-miR-10a-5p and hsa-miR-146a-5p, were target related to the roles of hUCMSC-Ex in papain-induced emphysema through VEGF-VEGFR2-mediated AKT and MEK/ERK pathways.
transcription factor target	36092502	hsa-mir-10a	Emphysema	Notably, several miRNAs, such as hsa-miR-10a-5p and hsa-miR-146a-5p, were target related to the roles of hUCMSC-Ex in papain-induced emphysema through VEGF-VEGFR2-mediated AKT and MEK/ERK pathways.
transcription factor target	36092346	hsa-mir-107	Esophageal Squamous Cell Carcinoma	CONCLUSIONS: MiR-107 negatively regulates TPM3 expression and plays a tumor suppression role in ESCC.
target gene	36092343	hsa-mir-147a	Colorectal Neoplasms	Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis.
genetics_knock down_promote	36092323	hsa-mir-149	Carcinoma, Hepatocellular	Inhibition of miR-149 or overexpression of CCND2 abrogated knockdown of circMMP9-mediated alleviation of the malignant phenotypes of HCC (P<0.05).
circRNA target	36092318	hsa-mir-425	Stomach Neoplasms	3p inhibition suppressed malignant progression by reducing GNG7 expression in GC cells.
lncRNA target	36092160	hsa-mir-7	Diabetic Retinopathy	In conclusion, our results demonstrate that HG-induced ZFAS1 elevation activates ferroptosis in hRECs and the ZFAS1/miR5p/ACSL4 axis may serve as a therapeutic target for endothelial dysfunction in DR.
transcription factor target	36092158	hsa-mir-155	Bloom Syndrome	Overall, this study demonstrated that BSYS has neuroprotective effects in myelin repair by modulating astrocyte polarization via the miR-155/SOCS1 pathway.
circulation_biomarker_diagnosis_up	36091385	hsa-let-7i	Fibrosis, Renal	It has been reported that let-7i-5p suppresses fibrotic disease in the heart, lungs, and blood vessels, while the role of let-7i-5p in renal fibrosis remains limited.
circulation_biomarker_diagnosis_ns	36091362	hsa-mir-23b	Acute Kidney Injury	Considering that LPS activates transcription factors that lead to the production of proinflammatory cytokines, possible premature changes in the serum levels of miR-181a-5p and miR-23b-3p may be used to identify sepsis-induced AKI earlier.
circulation_biomarker_diagnosis_ns	36091362	hsa-mir-181a	Acute Kidney Injury	Considering that LPS activates transcription factors that lead to the production of proinflammatory cytokines, possible premature changes in the serum levels of miR-181a-5p and miR-23b-3p may be used to identify sepsis-induced AKI earlier.
circulation_biomarker_diagnosis_ns	36091336	hsa-mir-4669	Rhinitis, Allergic	ROC curve highlighted that hsa-miR-4669 level exhibited a reliable accuracy in predicting SCIT efficacy in pediatric AR (AUC=0.785). Serum exosomes derived hsa-miR-4669 might serve as a novel biomarker for early predicting the response of SCIT in AR children.
lncRNA target	36091160	hsa-mir-150	Adenocarcinoma of Lung	3p axis based on ceRNA mechanism plays an important role in the development of LUAD and provides a new direction and theoretical basis for its targeted therapy.
circulation_biomarker_diagnosis_ns	36091129	hsa-mir-200c	Cholangiocarcinoma	3p, miR-200a-3p, miR-200c-3p in serum and bile, as well as miR-200b-3p and ENST00000588480.1 in bile showed AUCs of >0.70 in the diagnosis of CCA.
exosome	36091107	hsa-mir-4261	Multiple Myeloma	CONCLUSIONS: Studies have confirmed that RBCs experience calcium overload in MM with osteolytic lesions, which is related to the downregulation of ATP2B4 by MM exosomal miR-4261.
exosome	36090893	hsa-mir-563	Lung Neoplasms	Engineered Exosomes Loaded with miR-563 Inhibit Lung Cancer Growth.
other	36090753	hsa-mir-539	Diabetes Mellitus	5p-Dnmt3b axis might have therapeutic potential for addressing altered skeletal muscle physiology during insulin resistance and type 2 diabetes.
other	36090477	hsa-mir-20b	Glioma	Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy.
other	36089762	hsa-mir-29a	Tuberculosis	CONCLUSIONS: The levels of MiR-29a, Survivin and IFN-gamma was helpful for differential diagnosis of lung cancer and tuberculosis.
other	36089762	hsa-mir-29a	Lung Neoplasms	CONCLUSIONS: The levels of MiR-29a, Survivin and IFN-gamma was helpful for differential diagnosis of lung cancer and tuberculosis.
transcription factor target	36088985	hsa-mir-149	Inflammation	Finally, inhibition of miR-149 by antagomiR-149 blocked LPS-induced depression-like behavior by attenuating LPS-induced expression of NFATc4 in the PFC.
lncRNA target	36088979	hsa-mir-145	Atherosclerosis	CONCLUSION: DEHP could accelerate the atherosclerosis process through increasing VSMCs damage and formation of macrophage foam cell by increasing lipid uptake though down regulating lncRNA GAS5 and altering in regulation of miR
lncRNA target	36088911	hsa-mir-155	Carcinoma, Hepatocellular	DISCUSSION: RVT inhibits miR-155, activates autophagy, inhibits the toxicity for HepG2.2.15 cells, and reduces HBV replication, providing a new research direction for the treatment of HBV infection.
genetics_overexpression_promote	36088503	hsa-mir-7	Prostatic Neoplasms	In present study, we found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids and in vivo regardless of p53 status.
other	36088043	hsa-mir-4643	Polycystic Ovary Syndrome	5p, and miR-4643 in FF and CCs compared to control.
other	36088043	hsa-mir-212	Polycystic Ovary Syndrome	5p, and miR-4643 in FF and CCs compared to control.
other	36088043	hsa-mir-490	Polycystic Ovary Syndrome	5p, and miR-4643 in FF and CCs compared to control.
genetics_knock down_promote	36087939	hsa-mir-642a	Uterine Cervical Neoplasms	Rescue assays showed that NR2F1 knockdown or miR-642a-3p overexpression offset NR2F1-AS1 upregulation-induced inhibition on CC cell malignant phenotypes.
other	36087911	hsa-mir-451	Spinal Cord Injuries	CONCLUSIONS: Our findings have highlighted the potential anti-inflammatory role of miR-451 in reducing the secondary neuronal damage after spinal cord injury.
transcription factor target	36087740	hsa-mir-621	Colorectal Neoplasms	SIGNIFICANCE: MiR-621 is a vital tumor suppressor in CRC and could be a promising anti-cancer therapeutic target.
genetics_overexpression_promote	36087462	hsa-mir-144	Adenocarcinoma of Lung	5p was significantly down-regulated in LUAD, but overexpression of it repressed proliferation and spheroidization, and promoted apoptosis of LUAD cells.
transcription factor target	36087427	hsa-mir-200b	Cleft Palate, Non-Syndromic	CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes.
transcription factor target	36087427	hsa-mir-130b	Cleft Palate, Non-Syndromic	CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes.
transcription factor target	36087427	hsa-mir-212	Cleft Palate, Non-Syndromic	CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes.
circRNA target	36087384	hsa-mir-6779	Glioblastoma	Subsequently, we observed that circ-0010117 can regulate aggressiveness in glioblastoma cells through miR
genetics_overexpression_promote	36087376	hsa-mir-182	Brain Ischemia	CONCLUSION: Our findings suggest that overexpressing miR
genetics_overexpression_promote	36087376	hsa-mir-182	Brain Injuries	CONCLUSION: Our findings suggest that overexpressing miR
lncRNA target	36086973	hsa-mir-19a	Asthma	The down-regulation of miR-19a mRNA by activating JAK/STAT and NF-B signal pathways may be a possible mechanism by which WPCF alleviates airway inflammation.
target gene	36086826	hsa-mir-133a	Carcinoma, Hepatocellular	APS attenuated PD-L1-mediated immunosuppression via miR-133a-3p in HCC cells.
other	36086747	hsa-mir-944	Adenocarcinoma of Lung	In addition, our results reported for the first time that hsa-miR-3944 and hsa-miR-3652 were highly expressed in LUAD. Hsa-miR-3944 and hsa-miR-3652 may serve as new biomarkers in LUAD.
other	36086747	hsa-mir-652	Adenocarcinoma of Lung	In addition, our results reported for the first time that hsa-miR-3944 and hsa-miR-3652 were highly expressed in LUAD. Hsa-miR-3944 and hsa-miR-3652 may serve as new biomarkers in LUAD.
genetics_overexpression_promote	36085418	hsa-mir-591	Glioma	3p overexpression in glioma cell lines resulted in G2/M arrest and markedly increased apoptosis.
other	36085307	hsa-mir-155	ABCD syndrome	The mechanism underlying ABCD1 and ABCD2 repression involved RNA interference by the EBV-induced microRNAs miR5p and miR-155, respectively, causing significantly increased VLCFA levels.
other	36085307	hsa-mir-9	ABCD syndrome	The mechanism underlying ABCD1 and ABCD2 repression involved RNA interference by the EBV-induced microRNAs miR5p and miR-155, respectively, causing significantly increased VLCFA levels.
other	36084428	hsa-mir-181a	Carcinoma, Hepatocellular	The study demonstrates, for the first time, the OPN isoforms and its modulator miRNA-181a expression in EVs secreted by both cell lines, highlighting high levels of OPN isoforms in EVs secreted by HepG2 and identifying OPN as a promising biomarker for HCC diagnosis.
lncRNA target	36084427	hsa-mir-361	Carcinoma, Hepatocellular	5p inhibited the proliferation, metastasis, invasiveness, and epithelial-to-mesenchymal transition (EMT) process of HCC by targeting the transcription factor Twist1.
other	36084364	hsa-mir-128	Multiple Sclerosis	3p was stably expressed and associated with the PPMS subtype and correlated with disability accumulation.
transcription factor target	36084288	hsa-mir-27b	Chemical and Drug Induced Liver Injury	These findings suggest that inhibition of miR-27b-3p to activate the Nrf2/ARE pathway by GEN is a potential alternative for hepatic oxidative damage alleviation.
transcription factor target	36084159	hsa-mir-218	Peste-des-Petits-Ruminants	Here, we provide evidence that PPRV infection significantly induced the secretion levels of EVs from goat PBMC, and that PPRV-H protein carried in EVs can enhance SLAM receptor expression in the recipient cells via suppressing miR-218, a negative miRNA directly targeting SLAM gene.
other	36083527	hsa-mir-140	Diabetic Nephropathies	CONCLUSION: Circ_0080425 expression might contribute to HG-induced endothelial cell injury, and circ_0080425/miR3p/FN1 axis was a potential therapeutic approach to interfere DN process.
lncRNA target	36083475	hsa-mir-21	Ehlers-Danlos Syndrome, musculocontractural type 1	CONCLUSIONS: Our study revealed, for the first time, the ability of Qilan preparation to suppress TSCC cell growth and elucidated that Qilan preparation elicits its anti-cancer actions either the miR-21/PDCD4 or PTEN pathway.
other	36083239	hsa-mir-370	Carcinoma, Hepatocellular	3p in HCC metastasis.
transcription factor target	36082867	hsa-mir-125a	Breast Neoplasms	OBJECTIVE: We examined the association between miR-125a-5p and STAT3 expression levels in breast cancer patients for the first time through a case-control study on an Iranian population.
circulation_biomarker_diagnosis_up	36082835	hsa-mir-139	Spinal Cord Injuries	CONCLUSIONS: All the data found that serum upregulated SNHG3 and downregulated miR
lncRNA target	36082713	hsa-mir-152	Carcinoma, Hepatocellular	Conclusion miR-152 may inhibit EMT and RAS of HCCLM3 cells by targeting down-regulation of AGTR1 expression.
other	36082407	hsa-mir-141	Prostatic Neoplasms	Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
other	36082407	hsa-mir-145	Prostatic Neoplasms	Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
other	36082407	hsa-mir-148b	Prostatic Neoplasms	Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
other	36082407	hsa-mir-146a	Prostatic Neoplasms	Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
lncRNA target	36082081	hsa-mir-21	Reperfusion Injury, Renal Ischemia	Our findings underscore the potential utility of future clinical investigations of PPARgamma activation and targeting of the underlying miR-21/PDCD4/caspase-3 pathway, which may participate in the pathogenesis of human IRI.
other	36081896	hsa-mir-17	Alzheimer Disease	5p) were found to be related to MMSE scores.
lncRNA target	36081669	hsa-mir-199a	Liver Neoplasms	CONCLUSION: With high expression in LC cases, CDKN2B-AS1 is implicated in the development and progression of LC by suppressing cell autophagy through targeting miR-199a-5p.
lncRNA target	36081668	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	Moreover, we identified 5 pseudogenes and 33 long non-coding RNAs (lncRNAs) that might inhibit the hsa-miR
other	36081604	hsa-mir-149	COVID-19	5p/RIG-I, IL-6 axis could play a role in regulating the immune response against SARS-CoV-2.
lncRNA target	36081570	hsa-mir-564	Colorectal Neoplasms	CONCLUSIONS: Our study demonstrated that lncRNA 604 could promote the progression of CRC via the lncRNA 604/miRNA 564/AEG-1/EMT or lncRNA 604/ZNF326/EMT signaling axis.
other	36081272	hsa-mir-21	Breast Neoplasms	MicroRNA-21 (miRNA-21) is a common biomarker with high expression in breast tumors. Therefore, sensitive detection of miRNA-21 is of great significance for clinical breast tumor diagnosis.
other	36081236	hsa-mir-20a	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-345	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-141	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-27b	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-661	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-191	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-142	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
other	36081236	hsa-mir-372	Aneuploidy	In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR.
transcription factor target	36079691	hsa-mir-29a	Testicular Diseases	could protect against MTX-induced testicular injury by its antioxidant, anti-inflammatory, antiapoptotic activities and through the regulation of the miRNA-29a testicular expression.
exosome	36078172	hsa-mir-150	Osteoarthritis	EV-mediated miR-150-3p can be used to suppress OA, thus providing a novel therapeutic strategy.
genetics_GWAS	36078154	hsa-mir-146a	Immune System Diseases	We evaluated the expression of miR-146a-5p, a previously described negative regulator of immunity, in infants with respiratory diseases, in order to study epigenetic regulation of the immune response. In conclusion, infants with respiratory diseases present reduced miR-146a-5p expression, possibly affecting immune dysregulation.
genetics_GWAS	36078154	hsa-mir-146a	Respiration Disorders, Infant	We evaluated the expression of miR-146a-5p, a previously described negative regulator of immunity, in infants with respiratory diseases, in order to study epigenetic regulation of the immune response. In conclusion, infants with respiratory diseases present reduced miR-146a-5p expression, possibly affecting immune dysregulation.
lncRNA target	36078141	hsa-mir-221	Cleidocranial Dysplasia	These results demonstrate that OC-lncRNA-mediated osteoclast dysfunction via the OC-lncRNA-miR5p-CXCR3 axis, which is involved in the process of delayed tooth eruption of CCD.
lncRNA target	36078141	hsa-mir-221	Delayed Tooth Eruption	These results demonstrate that OC-lncRNA-mediated osteoclast dysfunction via the OC-lncRNA-miR5p-CXCR3 axis, which is involved in the process of delayed tooth eruption of CCD.
other	36078129	hsa-mir-221	Breast Neoplasms	Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management.
other	36078129	hsa-mir-16	Breast Neoplasms	Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management.
other	36078129	hsa-mir-15a	Breast Neoplasms	Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management.
other	36078109	hsa-mir-133a	Diabetes Mellitus, Type 2	MAO activity in T1D hearts increased miR-133a-3p, -193a-3p and -27a-3p expression.
circulation_biomarker_prognosis_ns	36078082	hsa-mir-222	Carcinoma, Hepatocellular	In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR
circulation_biomarker_prognosis_ns	36078082	hsa-mir-200c	Carcinoma, Hepatocellular	In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR
circulation_biomarker_prognosis_ns	36078082	hsa-mir-512	Carcinoma, Hepatocellular	In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR
other	36078059	hsa-mir-126	Diabetes Mellitus, Type 2	miR3p was regulated by both diabetes and H(2)S.
circRNA target	36078046	hsa-mir-370	Metabolic Diseases	The potential ceRNA mechanism identified the DEC target miRNAs-mRNAs involved in lipid metabolism, fat deposition, meat quality, and metabolic syndrome via the circRNA-miRNA-mRNA network, concluding that ssc-mir-370 is the most important target miRNA shared by both key circRNAs.
other	36077718	hsa-mir-188	Stomach Neoplasms	Hsa_circ_0044301 Regulates Gastric Cancer Cell's Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p/DAXX Axis and MAPK Pathway.
other	36077697	hsa-mir-129	Urinary Bladder Neoplasms	DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells.
other	36077665	hsa-mir-145	Thyroid Neoplasms	Taken together, the current study suggests that miR-145 may be a biomarker for PTC recurrence.
lncRNA target	36077591	hsa-mir-1	Arrhythmogenic Heart Diseases	We tested the new hypothesis that chronic distress, induced by rapid pacing, leads to increased reactive oxygen species, which promotes expression of a micro-RNA, miR-1, specific for the control of Cx43. In light of the high arrhythmogenic potential of altered Cx43 expression, we propose miR-1 as a novel target for pharmacological interventions to prevent the maladaptive remodeling processes during chronic distress in the heart.
lncRNA target	36077546	hsa-mir-6881	Carcinoma, Hepatocellular	AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats.
lncRNA target	36077546	hsa-mir-6881	Hepatitis	AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats.
lncRNA target	36077546	hsa-mir-6881	Pulmonary Fibrosis	AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats.
genetics_overexpression_promote	36077521	hsa-mir-143	Leukemia	3p overexpression in two T-ALL cell lines.
genetics_overexpression_promote	36077521	hsa-mir-143	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3p overexpression in two T-ALL cell lines.
other	36077457	hsa-mir-21	Cardiomyopathy, Dilated	In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium.
other	36077457	hsa-mir-21	Heart Failure, Ischemic	In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium.
other	36077457	hsa-mir-34a	Heart Failure, Ischemic	In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium.
other	36077457	hsa-mir-34a	Cardiomyopathy, Dilated	In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium.
circulation_biomarker_diagnosis_ns	36077347	hsa-mir-142	Myocardial Infarction	In conclusion, the increased plasma levels of mtDNA, along with miR
transcription factor target	36077117	hsa-mir-223	Arthritis, Rheumatoid	Furthermore, our data indicate that LSF, a selective inhibitor of STAT4, should be an ideal therapeutic agent for treating RA through down-regulating miRassociated osteoclastogenesis.
lncRNA target	36077054	hsa-mir-532	Breast Neoplasms	We show that both ADAR1 and METTL3 are upregulated in breast cancer samples, and ADAR1 positively correlates with METTL3; ADAR1 edits METTL3 mRNA and changes its binding site to miR532-5p, leading to increased METTL3 protein, which further targets ARHGAP5, recognized by YTHDF1.
circulation_biomarker_prognosis_up	36077039	hsa-mir-99b	Prostatic Neoplasms	Transfection of the miR-99b-5p mimic resulted in a significant reduction in nuclear mTOR and androgen receptor (AR), while a slight/moderate to no decrease in cytoplasmic mTOR and AR in PCa and other cancer cells, suggesting that miR-99b-5p inhibits mTOR and AR expression and their nuclear translocation.
lncRNA target	36077031	hsa-mir-133a	Fibrosis, Atrial	In conclusion, MiRNA let-7a, miR-let-7e and miR-133a play important roles in hypoxia-related atrial fibrosis by inhibiting collagen expression and post-transcriptional repression by the JNK pathway.
lncRNA target	36077031	hsa-let-7e	Fibrosis, Atrial	In conclusion, MiRNA let-7a, miR-let-7e and miR-133a play important roles in hypoxia-related atrial fibrosis by inhibiting collagen expression and post-transcriptional repression by the JNK pathway.
circulation_biomarker_prognosis_ns	36076930	hsa-mir-200	Breast Neoplasms	The extracellular circulating microRNA (miR)-200 regulates epithelial-mesenchymal transition and, thus, plays an essential role in the metastatic cascade and has shown itself to be a promising prognostic and predictive biomarker in metastatic breast cancer (MBC). In MBC patients, circulating miR-200 family members decreased after one cycle of a new line of systemic therapy, were elevated during PD, and were indicative of CTC status.
other	36076541	hsa-mir-148a	Atherosclerosis	The contribution of miR-148a-3p to the progression of atherosclerosis is unknown. CONCLUSIONS: Therapeutic silencing of miR148a mitigated the progression of atherosclerosis and promoted plaque stability.
other	36076541	hsa-mir-148	Atherosclerosis	The contribution of miR-148a-3p to the progression of atherosclerosis is unknown. CONCLUSIONS: Therapeutic silencing of miR148a mitigated the progression of atherosclerosis and promoted plaque stability.
other	36076490	hsa-mir-181b	Reperfusion Injury, Cerebral Ischemia	Our findings showed that BV could significantly improve CIR injury, both in vivo and in vitro, decrease LncRNA H19 and Esm1 expression, and increase miR-181b-5p expression. In conclusion, this study found that BV could ameliorate CIR injury by regulating the LncRNA H19/miR-181b-5p/Esm1 axis.
lncRNA target	36076481	hsa-mir-126	Diabetic Nephropathies	Due to the results, diabetes aggravates acute myocardial ischemia-reperfusion-induced kidney injury, while moderate-intensity interval training and Crataegus persica treatment simultaneously ameliorate myocardial ischemia-reperfusion-induced renal injury via miR-126/Nrf-2 pathway and improve insulin sensitivity and renal function in type 1 diabetic rats.
lncRNA target	36076481	hsa-mir-126	Diabetes Mellitus	Due to the results, diabetes aggravates acute myocardial ischemia-reperfusion-induced kidney injury, while moderate-intensity interval training and Crataegus persica treatment simultaneously ameliorate myocardial ischemia-reperfusion-induced renal injury via miR-126/Nrf-2 pathway and improve insulin sensitivity and renal function in type 1 diabetic rats.
other	36076347	hsa-mir-202	Sjogren's Syndrome	Hsa-miR-3202 was lower expressed in primary Sjogren's syndrome than healthy control.
other	36076300	hsa-mir-662	Graves Ophthalmopathy	Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified.
other	36076300	hsa-mir-144	Graves Ophthalmopathy	Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified.
other	36076300	hsa-mir-646	Graves Ophthalmopathy	Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified.
other	36076300	hsa-mir-12136	Graves Ophthalmopathy	Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified.
other	36076283	hsa-mir-155	Alzheimer Disease	The protective effects of microglial miR-155 ablation should shed light on potential treatments for retinal inflammation and vascular damage during AD and other ocular diseases.
circulation_biomarker_diagnosis_ns	36076132	hsa-mir-219	Meningioma	The serum level of miR-219 was studied in 56 meningioma samples WHO grade I = 22, WHO grade II = 14, and WHO grade III = 20).
lncRNA target	36076093	hsa-mir-454	Cardiomyopathy, Dilated	Enrichment analysis for the potential targeted mature mRNAs by miR
lncRNA target	36076093	hsa-mir-194	Cardiomyopathy, Dilated	Enrichment analysis for the potential targeted mature mRNAs by miR
exosome	36075289	hsa-mir-7219	Silicotuberculosis	In brief, our results demonstrated that exosomal miR3p played an important role in FMT and might be a novel therapeutic target of silicosis.
other	36075249	hsa-mir-124	Inflammatory Bowel Diseases	ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase BACKGROUND: ABX464 (obefazimod) is a small molecule that selectively upregulates miR-124 in immune cells.
genetics_GWAS	36075029	hsa-mir-146a	Inflammatory Bowel Diseases	The miR-146a rs2910164 C allele was significantly associated with increased risk of UC. In conclusion, miR-146a rs2910164 polymorphism may play a role in UC.
lncRNA target	36074900	hsa-mir-365	Anovulation	In summary, our findings reveal a cis-acting regulation mechanism of CYP11A1 through lncRNA, and define a novel signaling pathway, lnc2300/miR3p/CYP11A1 axis, which is involved in the regulation of GC apoptosis and follicular atresia.
circulation_biomarker_diagnosis_up	36074605	hsa-mir-132	Pneumonia	MATERIALS AND METHODS: Plasma samples were obtained from patients with pneumonia (n = 98) and healthy controls (n = 98) to detect the expression of circulating Arid2-IR and miR
circulation_biomarker_diagnosis_up	36074605	hsa-mir-132	Acute Lung Injury	MATERIALS AND METHODS: Plasma samples were obtained from patients with pneumonia (n = 98) and healthy controls (n = 98) to detect the expression of circulating Arid2-IR and miR
lncRNA target	36074434	hsa-mir-675	Tongue Neoplasms	CONCLUSIONS: Ginsenoside Rd inhibits tongue cancer cell migration and invasion via the H19/miR
genetics_overexpression_suppress	36074324	hsa-mir-21	Choriocarcinoma	5p overexpression and HIF1AN downregulation.
lncRNA target	36074257	hsa-mir-34b	Neurotoxicity Syndromes	Moreover, OIP5-AS1 could bind to miR-34b and OIP5-AS1 regulated BUP-induced neurotoxicity via miR-34b. In sum, our results disclosed that OIP5-AS1 ameliorated BUP-caused neurotoxicity via regulating the miR-34b/NFAT5 axis, suggesting that OIP5-AS1 might be a promising therapeutic target for the treatment of BUP-induced neurotoxicity.
transcription factor target	36074090	hsa-mir-181	Colitis	As epithelial reconstitution is crucial to restore intestinal homeostasis after injury, the miR-181 family represents a potential therapeutic target against severe intestinal inflammation.
circRNA target	36073553	hsa-mir-203a	Inflammation	In summary, our data revealed that circ_0123996 promoted the proliferation, inflammation, and fibrosis of mesangial cells via modulating the miR-203a-3p/SOX6 axis, suggesting that circ_0123996 might be a target for alleviating DN progression.
circRNA target	36073553	hsa-mir-203a	Diabetic Nephropathies	In summary, our data revealed that circ_0123996 promoted the proliferation, inflammation, and fibrosis of mesangial cells via modulating the miR-203a-3p/SOX6 axis, suggesting that circ_0123996 might be a target for alleviating DN progression.
lncRNA target	36073344	hsa-let-7b	COVID-19	These data suggest the involvement of hsa-let7b-5p in the regulation of genes necessary for SARS-CoV-2 infections and its putative role as a therapeutic target for COVID-19.
transcription factor target	36073218	hsa-mir-372	Colorectal Neoplasms	5p activates PI3K/AKT signaling pathway by targeting PTEN and up-regulates CXCL12 expression to promoting metastasis of colorectal cancer cells.
other	36072958	hsa-mir-21	Fibrosis	functionalized Ti substrates.
genetics_overexpression_promote	36072902	hsa-mir-122	Carcinoma, Renal Cell	Overexpression of miR-29a-3p or miR
genetics_overexpression_promote	36072902	hsa-mir-29a	Carcinoma, Renal Cell	Overexpression of miR-29a-3p or miR
other	36072900	hsa-mir-106a	Polycystic Ovary Syndrome	Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS.
other	36072900	hsa-mir-34a	Polycystic Ovary Syndrome	Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS.
other	36072900	hsa-mir-20a	Polycystic Ovary Syndrome	Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS.
other	36072900	hsa-mir-196a	Polycystic Ovary Syndrome	Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS.
other	36072900	hsa-mir-143	Polycystic Ovary Syndrome	Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS.
genetics_knock down_promote	36072768	hsa-mir-497	Depression	Knockdown of BDNF could abrogate the improving influences of miR
circulation_biomarker_diagnosis_up	36072634	hsa-mir-34	Hemoptysis	The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR-34 expression are compared among all groups at different time points.
circulation_biomarker_diagnosis_up	36072634	hsa-mir-34	Lung Neoplasms	The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR-34 expression are compared among all groups at different time points.
other	36072623	hsa-mir-182a	Ovarian Neoplasms	Malignant ovarian carcinoma cells recovered following miR-182A-3p downregulation. TYMP1 sequesters miR-182A-3p and promotes TGF1B in ovarian carcinoma, boosting carcinogenesis and cisplatin resistance.
genetics_knock down_promote	36072619	hsa-mir-10b	Mouth Neoplasms	Finally, it was discovered that AKT signaling participates in regulating exosome-mediated invasion and migration of oral cancer cells and its activation reduced the inhibitory effect of miR-10b knockdown on oral cancer cells.
lncRNA target	36072399	hsa-mir-378a	Rhinitis, Allergic	CONCLUSIONS: MiR-378a-3p can accelerate the pathological development of AR through targeted inhibition on the release of pro-inflammatory factors such as IgE and HA activated by GzmB, so it is a promising molecular target of AR therapy and offers a novel research direction for the complete cure of AR.
other	36072391	hsa-mir-105a	bladder urothelial carcinoma	RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214).
other	36072391	hsa-mir-214	bladder urothelial carcinoma	RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214).
other	36072391	hsa-mir-181a	bladder urothelial carcinoma	RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214).
other	36072391	hsa-mir-143	bladder urothelial carcinoma	RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214).
lncRNA target	36071871	hsa-mir-138	Carcinoma, Hepatocellular	5p/HIF-1alpha as a potential therapeutic target for sensitizing HCC to radiotherapy.
lncRNA target	36071684	hsa-mir-2681	Atherosclerosis	Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression.
lncRNA target	36071684	hsa-mir-2681	Carotid Artery Diseases	Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression.
lncRNA target	36071682	hsa-mir-193a	AIDS-Related Complex	In conclusion, circMAP3K4 protected SRA01/04 cells from H(2)O(2)-induced dysfunction in ARC through mediating miR-193a-3p/PLCD3 axis.
lncRNA target	36071678	hsa-mir-513a	Colonic Neoplasms	Therefore, we identified that circPLOD2 promoted colon cancer progression through miR-513a-5p/SIX1/LDHA axis, and acted as a new biomarker for colon cancer prognosis and treatment.
genetics_overexpression_promote	36071480	hsa-mir-383	Carcinoma, Hepatocellular	Either downregulation of MCUR1 or overexpression of miR-383 improved DOX sensitivity in HCC cells.
genetics_overexpression_promote	36071475	hsa-mir-26a	Neuralgia	In addition, Foxy5, a mimetic peptide of Wnt5a, can significantly reverse the inhibitory effect of miR-26a-5p on neuroinflammation and neuropathic pain, and at the same time, miR-26a-5p can rescue the effect of Foxy5 by overexpression.
exosome	36071344	hsa-mir-199a	Pre-Eclampsia	Our previous study implied the important role of exosomal miR-199a-5p in preeclampsia with severe features (sPE). Furthermore, exosomal miR-199a-5p could impair the endothelial cell function via targeting SIRT1, contributing to the development of preeclampsia.
genetics_GWAS	36071121	hsa-mir-145	Asthma	We hypothesize that single nucleotide polymorphisms (SNPs) in the promoter region of miR-145 may be associated with the risk of asthma in Taiwanese.
circulation_biomarker_diagnosis_up	36070969	hsa-mir-455	Fractures, Bone	RESULTS: Serum miR
circulation_biomarker_diagnosis_up	36070969	hsa-mir-455	Osteoporosis	RESULTS: Serum miR3p was significantly decreased in both osteoporosis and fragility fracture patients compared with the control group, which was most deficient in patients with fragility fracture.
lncRNA target	36070614	hsa-mir-1	Cardiomegaly	In summary, our study identified the modulatory role linc-RMRP played in regulating PE-induced CH by means of binding miR-1, and this might provide a new target for cardiac hypertrophy therapy.
circulation_biomarker_diagnosis_ns	36069974	hsa-mir-542	Pneumonia, Mycoplasma	CONCLUSIONS: Downregulation of LINC00221 might reduce dysfunction, inflammatory responses, endoplasmic reticulum stress, and oxidative stress, and thereby protect against PE by augmenting miR3p.
circRNA target	36069177	hsa-mir-200c	Fibrosis, Renal	circACTR2, by targeting and sponging miR-200c, activates YAP signalling, stimulates M2 macrophage polarization and promotes the development of RF.
circulation_biomarker_diagnosis_ns	36068979	hsa-mir-16	Coronary Artery Disease	Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease.
circulation_biomarker_diagnosis_ns	36068979	hsa-mir-21	Coronary Artery Disease	Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease.
circulation_biomarker_diagnosis_ns	36068979	hsa-mir-92a	Coronary Artery Disease	Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease.
genetics_overexpression_promote	36068615	hsa-mir-369	Intervertebral Disc Degeneration	RESULTS: Western blotting, qPCR, and flow cytometry analyses confirmed that overexpression of circ_7042 could downregulate miR
lncRNA target	36068004	hsa-mir-892b	Urinary Bladder Neoplasms	Reduction of miR-892b relieved si-circ_0003221-induced anti-tumor response in BLCA cells. CONCLUSIONS: The current evidence elucidated circ_0003221 targeted miR-892b to elevate the DHCR24 level, thus accelerating cell development and glycolytic metabolism of BLCA cells.
lncRNA target	36067951	hsa-mir-423	Reperfusion Injury, Cerebral Ischemia	In conclusion, inhibition of miR
lncRNA target	36067544	hsa-mir-33a	Osteosarcoma	Furthermore, it was verified that JPX acts as a sponge for miR-33a-5p, and that JPX regulated OS cell proliferation, migration and invasion through miR-33a-5p. Moreover, down-regulation of miR-33a-5p in OS contributed to PNMA1 upregulation, and PNMA1 depletion inhibited OS cell proliferation, migration and invasion in vitro.
lncRNA target	36067543	hsa-mir-3163	Colorectal Neoplasms	Subsequently, we testified that FAM201A exerted its role in the tumorigenesis and development of CRC through targeting miR-3163/MACC1. In conclusion, our study was the first to unveil that FAM201A promoted cell proliferation and CSC characteristics in CRC via regulation of the miR-3163/MACC1 axis, which provided clues for the clinical treatment of patients with this disease.
circRNA target	36067529	hsa-mir-651	Colorectal Neoplasms	Circ_0000467 may enhance the growth and metastasis of CRC cells by targeting miR
other	36067193	hsa-mir-1	Spinal Cord Injuries	CONCLUSION: Our experiment demonstrated that miR-31 could promote the migration of BMSCs and miR-31 could repair and improve the function of damaged tissues in SCI.
genetics_overexpression_suppress	36067091	hsa-mir-200c	Thyroid Carcinoma, Anaplastic	Overexpression of miR-200c inhibited the invasion, proliferation, and colony formation of the ATC cell lines, whereas its downregulation achieved the opposite results.
other	36066909	hsa-mir-103a	Pulmonary Disease, Chronic Obstructive	In this study, we found that miR-103a expression was significantly reduced in alveolar macrophages from smokers and patients with COPD versus that in alveolar macrophages from nonsmokers. Taken together, our findings indicate that downregulation of miR-103a contributes to cigarette smoke-induced lipid-laden macrophage formation and plays a critical role in lipid homeostasis in lung macrophages in the pathogenesis of COPD.
lncRNA target	36066507	hsa-mir-623	Glioblastoma	RP11-89 suppressed the role of miR-623 in downregulating cyclin D1 and GBM cell proliferation.
genetics_overexpression_promote	36066402	hsa-mir-299	Lung Neoplasms	3p inhibitor or SLC38A1 overexpression attenuated OGFRP1 depletion-induced suppression on cell proliferation and ferroptosis in lung cancer.
genetics_knock down_promote	36066401	hsa-mir-449a	Thyroid Cancer, Papillary	CircMAN1A2 acted as a molecular sponge of miR-449a, and circMAN1A2 knockdown suppressed PTC development partly through upregulating miR-449a.
circRNA target	36066399	hsa-mir-31	Carcinoma, Non-Small-Cell Lung	In-vivo analysis indicated that circHMGA2 inhibition also reduced tumorigenesis and glycolysis of NSCLC via the miR
lncRNA target	36066393	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	In addition, miR-199a-5p exerts an inhibitory effect in NSCLC cells by inhibiting SphK2. This research demonstrated that circ_0007841 had a positive influence in improving NSCLC development by targeting miR-199a-5p and upregulating oncogene SphK2.
other	36066383	hsa-mir-370	Lymphoma, Large B-Cell, Diffuse	Our findings revealed that circ_0000877 could regulate the malignant evolution of DLBCL by miR3p/MAP4K4/Hippo pathway.
lncRNA target	36066055	hsa-mir-186	Trigeminal Neuralgia	5p in a rat model (adult male Sprague-Dawley rats, 7-8 weeks old, 180-200 g) of trigeminal neuralgia (TN) established via chronic constriction injury of the infraorbital nerve (ION-CCI).
other	36065995	hsa-mir-124	Ischemic Stroke	The combination of Ca-MOF@miR-124 nanoparticles and NSC therapy will enhance the treatment of traumatic nerve injury and neurodegenerative diseases.
genetics_overexpression_suppress	36065643	hsa-mir-148a	Carcinoma, Hepatocellular	miR-148a-3p mimic-mediated apoptosis and the inhibition of HCC cell growth and migration were counteracted by CTSA overexpression.
circulation_biomarker_diagnosis_up	36065413	hsa-mir-486	Obesity	RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b
circulation_biomarker_diagnosis_up	36065413	hsa-mir-20a	Obesity	RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b
circulation_biomarker_diagnosis_up	36065413	hsa-mir-125b-1	Obesity	RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b
lncRNA target	36065412	hsa-mir-604	Colorectal Neoplasms	circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis.
other	36065304	hsa-mir-16	Colonic Neoplasms	5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD.
other	36065304	hsa-mir-141	Colonic Neoplasms	5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD.
other	36065304	hsa-mir-200a	Colonic Neoplasms	5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD.
other	36065304	hsa-mir-148a	Colonic Neoplasms	5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD.
other	36064821	hsa-mir-672	Neuralgia	5p directly regulated the expression of REEP6, which participated in the neuronal hyperexcitability in the spinal dorsal horn and neuropathic pain following BTZ treatment.
lncRNA target	36064768	hsa-mir-30	Brain Injuries, Traumatic	5p, SHED-EVs favored anti-inflammatory microglia polarization through Ehmt2 mediated CXCL14 transcription in treating traumatic brain injury.
lncRNA target	36064706	hsa-mir-32	Colorectal Neoplasms	CONCLUSION: In summary, we propose that in CRC, poised chromatin and miR-32 decrease the expression of MARCH8, further bind and add ubiquitin, induce HK2 degradation, and finally repress glycolysis to promote tumor suppressors in CRC.
transcription factor target	36064576	hsa-mir-590	Triple Negative Breast Neoplasms	MiR3p directly targeted the TRAIP 3'-UTR, and its expression were lower in TNBC tissues.
circRNA target	36064433	hsa-mir-199b	Leukemia, Lymphocytic, Chronic, B-Cell	Mechanistically, circRIC8B acted as a sponge of miR-199b-5p and prevented it from decreasing the level of LPL mRNA, and this promotes lipid metabolism alteration and facilitates the progression of CLL. Our findings revealed that circRIC8B regulates the lipid metabolism abnormalities in and development of CLL through the miR-199b-5p/LPL axis.
other	36064409	hsa-mir-885	Stomach Neoplasms	3p, thereby promoting GC development.
genetics_overexpression_suppress	36064348	hsa-mir-18a	Squamous Cell Carcinoma of Head and Neck	Furthermore, the migration and invasion abilities of OSCC cells were significantly decreased by miRNA-18a mimics and significantly increased by the overexpression of HIF-1alpha under hypoxic conditions relative to those abilities in cells treated only with miRNA-18a mimics.
lncRNA target	36064035	hsa-mir-29b	Aortic Valve Disease	Then, we found that miR-29b participated in the NLRP3-regulated CAVD pathway through its target gene STAT3 (signal transducer and activator of transcription 3).
genetics_overexpression_suppress	36063796	hsa-mir-204	Carcinoma, Renal Cell	5p restored the promoting impact of overexpression of GXYLT2 on malignant progression of ccRCC cells.
lncRNA target	36063543	hsa-mir-197	Polycystic Ovary Syndrome	3p exhibits a negative regulatory role in regulating granulosa ovarian cell proliferation via posttranscriptional repression of CUL3 in PCOS.
circRNA target	36063260	hsa-mir-1178	Pancreatic Carcinoma	3p and increasing BNIP3, implying the potential implication of circDUSP22 in targeted therapy of PaCa.
other	36062491	hsa-mir-148a	Obesity	Those results suggested that Ago2-miR-148a-AMPKalpha signaling pathway play an important function in the developing obesity and adiposity, and will further provide basic research data for the potential clinical treatment of obesity.
other	36062412	hsa-mir-200c	Colonic Neoplasms	In PDCs, miR-141, miR-200c, and CDH1 were significantly downregulated.
other	36062412	hsa-mir-141	Colonic Neoplasms	In PDCs, miR-141, miR-200c, and CDH1 were significantly downregulated.
lncRNA target	36062277	hsa-mir-494	Carcinoma, Hepatocellular	CONCLUSIONS: EPS1-1 protected against HCC by limiting its proliferation and survival through the miR
target gene	36062165	hsa-mir-21	Colorectal Neoplasms	LncRNA GAS5 Suppresses Colorectal Cancer Progress by Target miR-21/LIFR Axis.
epigenetics	36061358	hsa-mir-613	Nasopharyngeal Carcinoma	Collectively, miR-613 inhibited DNMT3B, reduced TIMP3 methylation, and increased TIMP3 protein level, thus inhibiting the STAT1/FOXO1 pathway and enhancing the radiosensitivity of NPC cells.
genetics_knock down_promote	36061355	hsa-mir-22	Colorectal Neoplasms	Additional functional experiments confirmed that MAX overexpression can rescue the effects of miR-22 on the behavior of CRC cells.
other	36061211	hsa-mir-422a	Inflammatory Bowel Diseases	CTLA4, which has immune-related properties, can be a potential biomarker in UC, and MIAT/miR-422a/CTLA4 ceRNA networks may play important roles in UC.
lncRNA target	36061185	hsa-mir-33a	Glioma	We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction.
lncRNA target	36061185	hsa-mir-33a	Sarcopenia	We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction.
exosome	36061148	hsa-mir-3960	Osteoarthritis	We aimed to investigate the effects of EV-encapsulated miR-3960 derived from MSCs on chondrocyte injury in OA.
exosome	36061148	hsa-mir-3960	Cartilage Diseases	We aimed to investigate the effects of EV-encapsulated miR-3960 derived from MSCs on chondrocyte injury in OA.
genetics_overexpression_promote	36060928	hsa-mir-212	Cardiomegaly	The overexpression of miR-212 adenovirus was constructed, and the expression of miR-212 was overexpressed, and its effect on cardiac hypertrophy (CH) was detected by immunofluorescence and qRT-PCR.
lncRNA target	36060794	hsa-mir-942	Hypertension, Pulmonary	Conclusion Our findings demonstrated that diminished circGSAP accelerated cell cycle to facilitate cell proliferation and apoptosis resistance through competitively binding miR5p to modulate SMAD4 expressions in hypoxia-induced PMECs, indicating potential therapeutic strategies for PH.
other	36060256	hsa-mir-873	Thyroid Neoplasms	CYTOR-hsa-miRNA5p-CDKN2A regulatory networks and single copy number deletion of CDKN2A may also affect THCA' progression and prognosis.
lncRNA target	36060149	hsa-mir-185	Carcinoma, Non-Small-Cell Lung	Our data suggested that LINC00174 aggravated LUSC progression via serving as a competing endogenous RNA (ceRNA) to sponge miR5p and ultimately upregulate NFIX, which offered a promising novel target for LUSC therapy.
lncRNA target	36060143	hsa-mir-200a	Stomach Neoplasms	These results indicate that XTSJ may affect EMT and Bcl-2 signaling pathways by regulating lncRNA-ATB and miR-200a, thus inhibiting proliferation, migration, and invasion of HGC-27 cells.
epigenetics	36060016	hsa-mir-18a	Colorectal Neoplasms	The aim of this study was to establish whether there is a relationship between the expression of the wild-type KRAS gene, the methylation status of its distal promoter, and miR-143 and miR-18a-3p levels in samples of sporadic CRC.
epigenetics	36060016	hsa-mir-143	Colorectal Neoplasms	The aim of this study was to establish whether there is a relationship between the expression of the wild-type KRAS gene, the methylation status of its distal promoter, and miR-143 and miR-18a-3p levels in samples of sporadic CRC.
genetics_knock down_suppress	36059820	hsa-mir-146a	Chronic  Kidney Disease	Furthermore, induction of hyperglycemia using streptozotocin (STZ) also resulted in an accelerated development of glomerulopathy and a rapid increase in proteinuria in the knockout animals, as compared to the WT animals, further confirming the protective role of podocyte-expressed miR-146a.
genetics_knock down_suppress	36059820	hsa-mir-146	Chronic  Kidney Disease	Furthermore, induction of hyperglycemia using streptozotocin (STZ) also resulted in an accelerated development of glomerulopathy and a rapid increase in proteinuria in the knockout animals, as compared to the WT animals, further confirming the protective role of podocyte-expressed miR-146a.
target gene	36059813	hsa-mir-145	Breast Neoplasms	CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis.
genetics_knock down_promote	36059806	hsa-mir-485	Pancreatic Carcinoma	We confirmed that circLMTK2 knockdown attenuated GEM-resistant PC cells by regulating PAK1 via miR
genetics_knock down_promote	36059797	hsa-mir-299	Nasopharyngeal Carcinoma	Overexpression of MMP-2 substantially reduced the miR
target gene	36059697	hsa-mir-1	Prostatic Neoplasms	miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer.
other	36059695	hsa-mir-124	Lymphoma, T-Cell, Cutaneous	Our study provides a rationale for further studies focused on an evaluation of MALAT1-miR-124 in CTCL progression.
lncRNA target	36059662	hsa-mir-186	Adenocarcinoma of Lung	METHODS: Regarding the public databases and based on integrating bioinformatics analyses, we determined whether LncRNA-AC009948.5 exerts its oncogenic functions via sponging miR5p in LUAD.
other	36059626	hsa-mir-186	Osteosarcoma	Mechanism studies revealed that circ0038632 sponged miR-186 to upregulate the expression of DNA methyltransferase 3A (DNMT3A) to promote osteosarcoma progression. The circ0038632/miR-186/DNMT3A axis was involved in osteosarcoma progression.
transcription factor target	36059036	hsa-mir-124	Autism Spectrum Disorder	This study revealed an unanticipated role of the miR-124/Nr4a1 signaling in regulating early social experience-dependent mPFC myelination, which may serve as a potential therapy target for social neglect or social isolation-related neuropsychiatric disorders.
lncRNA target	36058969	hsa-mir-429	Breast Neoplasms	In breast cancer, the levels of oncogenic microRNA (miR-21, miR-221, and miR-27a) were increased, while the level of tumor-suppressing miR-429 was reduced in comparison with the intact group. The level of tumor-suppressing miR-429 in breast tumor tissues remained reduced, as in the untreated breast cancer group.
target gene	36058922	hsa-mir-877	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation.
transcription factor target	36058441	hsa-mir-21	Heart Diseases	CONCLUSION: In human cardiomyocytes, the abundance of miRNA-21 takes part in first defense mechanism against cardiac insult and its cardioprotective effect depends on time of exposure to injury.
transcription factor target	36058294	hsa-mir-34a	Diabetes Mellitus	Our findings highlight a critical role of miR-34a-5p in the regulation of hepatic gluconeogenesis and miR-34a-5p may be a potential target in the treatment of type 2 diabetes.
transcription factor target	36058294	hsa-mir-34a	Diabetes Mellitus, Type 2	Our findings highlight a critical role of miR-34a-5p in the regulation of hepatic gluconeogenesis and miR-34a-5p may be a potential target in the treatment of type 2 diabetes.
lncRNA target	36058131	hsa-mir-376a	Adenocarcinoma of Lung	The interactions between TRIM36, RAD1 and hsa-miR-376a-5p can be future therapeutic targets to increase radiation sensitivity in LUAD patients.
other	36058014	hsa-mir-129	Thyroid Cancer, Papillary	Circ_0027446 induces CLDN1 expression to promote papillary thyroid cancer cell malignancy by binding to miR-129-5p.
genetics_knock down_suppress	36057400	hsa-mir-6918	Reperfusion Injury	5p enhanced the ischemic AKI; this was diminished by MBD2-KO.
lncRNA target	36057399	hsa-mir-376b	Non-alcoholic Fatty Liver Disease	Thus, miR-376b-3p may serve as a potential diagnostic marker or therapeutic target for NAFLD.
lncRNA target	36057384	hsa-mir-1303	Tuberculosis	3p down-regulation and miR-1303 up-regulation accompanied with corresponding changes in their predicted target genes in an independent validation cohort of 46 active TB patients, 30 latent TB infection subjects, and 24 non-infected healthy subjects.
lncRNA target	36057384	hsa-mir-431	Tuberculosis	3p down-regulation and miR-1303 up-regulation accompanied with corresponding changes in their predicted target genes in an independent validation cohort of 46 active TB patients, 30 latent TB infection subjects, and 24 non-infected healthy subjects.
circulation_biomarker_diagnosis_up	36057114	hsa-mir-1	Azoospermia	The use of total seminal plasma as an analytical sample would facilitate the use of a simplified technical procedure for miR
transcription factor target	36057111	hsa-mir-34	Autographa californica multiple nuclear polyhedrosis virus	frugiperda in the anti-Autographa californica multiple nucleopolyhedrovirus (AcMNPV), providing a reference for the design of a miR5p target biopesticide against S.
genetics_knock down_promote	36056852	hsa-mir-1260b	Breast Neoplasms	Knockdown of miR-1260b significantly suppressed breast cancer cell migration and invasion and yielded the opposite result.
circRNA target	36056804	hsa-mir-1182	Carcinoma, Non-Small-Cell Lung	Moreover, TFAM was targeted by miR-1182, and miR-1182 hindered NSCLC cell progression by regulating TFAM. Additionally, circ_0002476 silencing could reduce NSCLC tumor growth by miR-1182/TFAM.
lncRNA target	36056431	hsa-mir-185	Uterine Cervical Neoplasms	5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical cancer.
target gene	36056285	hsa-mir-761	Ovarian Neoplasms	Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling.
other	36054706	hsa-mir-26b	Chronic Periodontitis	MATERIALS AND METHODS: Expression of miR-26a-5p and miR-26b-5p was quantified in gingival biopsies derived from healthy and periodontally diseased subjects before and after non-surgical (scaling and root planing) therapy by RT-qPCR.
other	36054706	hsa-mir-26a	Chronic Periodontitis	CONCLUSIONS: Downregulated miR-26a-5p levels in periodontal inflammation may interfere with key cellular functions that may have significant implications for host defence and wound healing.
lncRNA target	36054700	hsa-mir-216a	Uterine Cervical Neoplasms	Whereas, transfection of miR-216a-3p inhibitor partially reverses the above cellular activities changes in cervical cancer cells.
genetics_overexpression_promote	36054559	hsa-mir-128	Carcinoma, Non-Small-Cell Lung	3p overexpression-induced apoptosis and autophagy inhibition in NSCLC by increasing the phosphorylation of JAK2 and STAT3.
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-142	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-let-7	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
other	36054529	hsa-mir-4791	Diabetes Mellitus, Type 2	In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p&lt;0.01) and lower levels of miR-4284 and miR-4791 (p&lt;005), than their peers without IR in both the whole sample and in those with overweight or obesity.
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-142	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-190a	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-190a	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-374a	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-20a	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-374a	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-20a	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-660	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
other	36054529	hsa-mir-4791	Metabolic Associated Fatty Liver  Disease 	In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p&lt;0.01) and lower levels of miR-4284 and miR-4791 (p&lt;005), than their peers without IR in both the whole sample and in those with overweight or obesity.
circulation_biomarker_diagnosis_ns	36054529	hsa-let-7	Metabolic Associated Fatty Liver  Disease 	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
other	36054529	hsa-mir-4284	Metabolic Associated Fatty Liver  Disease 	In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p&lt;0.01) and lower levels of miR-4284 and miR-4791 (p&lt;005), than their peers without IR in both the whole sample and in those with overweight or obesity.
other	36054529	hsa-mir-4284	Diabetes Mellitus, Type 2	In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p&lt;0.01) and lower levels of miR-4284 and miR-4791 (p&lt;005), than their peers without IR in both the whole sample and in those with overweight or obesity.
circulation_biomarker_diagnosis_ns	36054529	hsa-mir-660	Diabetes Mellitus, Type 2	5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR
genetics_knock down_promote	36054164	hsa-mir-942	Breast Neoplasms	5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression.
exosome	36053959	hsa-mir-1224	Osteopenic Nonfracture Syndrome	The analysis of miRNome revealed that miR-1246 and miR5p were the most upregulated and downregulated in OP EVs; the modulated EV-miRNAs in OP and OPN compared to CN are related to osteoclast differentiation, interleukin-13 production and regulation of canonical WNT pathway.
exosome	36053959	hsa-mir-1224	Osteoporosis	The analysis of miRNome revealed that miR-1246 and miR5p were the most upregulated and downregulated in OP EVs; the modulated EV-miRNAs in OP and OPN compared to CN are related to osteoclast differentiation, interleukin-13 production and regulation of canonical WNT pathway.
genetics_knock down_suppress	36053930	hsa-mir-4282	Breast Neoplasms	LINC00536 knockdown inhibits breast cancer cells proliferation, invasion, and migration through regulation of the miR-4282/centromere protein F axis.
lncRNA target	36053456	hsa-mir-149	Adrenal Cortex Neoplasms	3p promotes H295A cell viability by downregulating CDKN1A and provide evidence that miR
genetics_overexpression_promote	36053263	hsa-mir-192	Hepatitis B	5p inhibitor-transfected group exhibited the opposite results, and ATG7 overexpression reversed the effects of miR
circulation_biomarker_diagnosis_up	36053124	hsa-mir-515	Prostatic Neoplasms	Plasmacytoma variant translocation 1 inhibits miR-515-5p function and modulates high mobility group B3 to promote the growth of prostate cancer cells.
tissue_expression_ns	36052916	hsa-mir-222	Carotid Stenosis	The ROC, Kaplan-Meier, and Cox regression analyses were carried out to estimate the diagnostic and prognostic value of GAS5 and miR
genetics_knock down_suppress	36052886	hsa-mir-335	Acute Kidney Injury	Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR
genetics_knock down_suppress	36052886	hsa-mir-335	Sepsis	Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR
lncRNA target	36052873	hsa-mir-216a	Inflammation	CONCLUSIONS: TG protects chondrocytes against IL-1beta-induced inflammation and apoptosis via miR-216a-5p/TLR4/NF-kappaB axis.
genetics_knock down_suppress	36052865	hsa-mir-363	familial febrile seizures 1	Furthermore, PDCD6IP knockdown imitated, while overexpression reversed the effects of miR3633p overexpression on OGD/Rinduced cell injury.
genetics_overexpression_promote	36052751	hsa-mir-10b	Glioma	The macrophages or glioma cells were transfected with overexpressing plasmid or shRNA to study the effects of miR-10b-5p/NEDD4L/PIK3CA on M2 macrophage polarization, and glioma cell proliferation, migration, and invasion in vitro and in vivo.
other	36052691	hsa-mir-342	Pancreatitis	ASAP1-IT2/DGCR9-hsa-miR5p-ABCC5/MAP2K6 was the only one specific interaction pair identified in ARP.
other	36052236	hsa-mir-532	Carcinoma, Renal Cell	In conclusion, our study identified the PVT1/SNHG15-hsa-miR3p-PLAUR axis and a prognostic signature of PRIs, which could be a reference for future clinical research.
other	36051820	hsa-mir-29c	Nephritis, Interstitial	miR-29c, which is an antifibrotic microRNA, downregulates renal interstitial fibrosis by downregulating the TGF-beta and collagen.
genetics_overexpression_promote	36050752	hsa-mir-338	Arthritis, Rheumatoid	Silencing of NEAT1 and overexpression of miR
lncRNA target	36050724	hsa-mir-143	Triple Negative Breast Neoplasms	mediated inhibition of glycolysis for reversing GEM resistance in TNBC.
other	36050647	hsa-mir-202	Migraine Disorders	5p.
other	36050647	hsa-mir-7855	Migraine Disorders	5p.
other	36050647	hsa-mir-1538	Migraine Disorders	5p.
other	36050647	hsa-mir-6770	Migraine Disorders	5p.
other	36050647	hsa-mir-409	Migraine Disorders	5p.
other	36050615	hsa-mir-198	Carcinoma, Hepatocellular	Previous screening on patient specimens identified miR-198 as the most downregulated miRNA in HCC.
lncRNA target	36049539	hsa-mir-885	Lupus Erythematosus, Cutaneous	5p in CLE KCs, leading to epidermal inflammation by NF-kappaB activity enhancement and proliferation through PSMB5 and immune recruitment through TRAF1.
other	36049464	hsa-mir-26a	Neural Tube Defects	The present study aimed to explore the potential role of miRNA-26a in NTDs and the underlying pathogenesis thereof. First, we found significantly increased miRNA-26a expression in fetuses with NTDs (p < 0.0001), which significantly downregulated EphA2 and ERK1 mRNA and protein expression levels in fetuses with NTDs compared to normal controls (p < 0.01).
target gene	36049358	hsa-mir-204	Breast Neoplasms	Circular RNA circMET contributes to tamoxifen resistance of breast cancer cells by targeting miR-204/AHR signaling.
circulation_biomarker_diagnosis_ns	36048908	hsa-mir-24	Cardiovascular Diseases	CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.
circulation_biomarker_diagnosis_ns	36048908	hsa-let-7a	Arthritis, Rheumatoid	CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.
circulation_biomarker_diagnosis_ns	36048908	hsa-mir-24	Arthritis, Rheumatoid	CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.
circulation_biomarker_diagnosis_ns	36048908	hsa-let-7a	Cardiovascular Diseases	CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.
other	36048381	hsa-mir-206	Pre-Eclampsia	miR-206 and miR-30a play a role by regulating CD39 and CD73 as molecules that are involved in ATP catabolism as well as regulating the production of IGF-1 in the process of hypertension, which is the main feature in patients with preeclampsia.
other	36048381	hsa-mir-18a	Pre-Eclampsia	On the other hand, decreased level of miR-18a lead to upregulation of HIF-1a, and the consequence condition of hypoxia increases hypertension and inflammation in these patients.
transcription factor target	36047894	hsa-mir-23a	Aortic Aneurysm, Abdominal	Our findings suggest that miRNA-323a-3p targeting AdipoR1 is promising in further anti-inflammatory treatment of IAs.
circulation_biomarker_diagnosis_ns	36047533	hsa-mir-101	Diabetes, Gestational	CONCLUSION: Serum miR-101 level may be a biomarker for grading HDCP.
other	36047424	hsa-mir-181b	Urinary Bladder Neoplasms	3p.
other	36047424	hsa-mir-221	Urinary Bladder Neoplasms	3p.
exosome	36046998	hsa-mir-374	Spinal Cord Injuries	5p in neuronal exosomes could enhance spinal cord injury recovery by activating autophagy.
lncRNA target	36046997	hsa-mir-204	Osteoporosis	OBJECTIVE: To explore the regulation of LncRNA TUG /miRNA-204/SIRT1 pathway on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), so as to provide a new theoretical basis for the clinical treatment of osteoporosis. CONCLUSION: This study found the direct regulatory relationship of LncRNA TUG/miR-204/SIRT1 during the osteogenic differentiation of BMSCs, and revealed that SIRT1 positively regulates the osteogenic differentiation of BMSCs, which provides a theoretical basis and potential therapeutic targets for a series of osteogenic differentiation-related diseases including osteoporosis.
genetics_knock down_promote	36046641	hsa-let-7c	Adenocarcinoma of Lung	Results: Finally, circRNA_0039908/let7c-5p/RRM2 axis was identified in our research, it can play an important role in the LUAD pathogenesis progression and we found that the proliferation, invasion and migration abilities of LUAD cells can be suppressed after knockdown of circRNA_0039908. This work indicates that circRNA_0039908/let7c-5p/RRM2 axis may be a promising target in the prognosis and treatment of LUAD patients.
target gene	36046633	hsa-mir-2052	Breast Neoplasms	LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis.
genetics_knock down_promote	36046536	hsa-mir-145	Neoplasm Metastasis	Overexpression of MEG3 was able to decrease miR-145 level and NEDD9 protein level in Cr(VI)-transformed cells.
transcription factor target	36046375	hsa-mir-381	Carcinoma, Non-Small-Cell Lung	miR-381 Inhibits Proliferation and Invasion of Non-Small-Cell Cancer Cells by It is known that miR-381 plays a therapeutic role in a variety of cancers, but the regulatory mechanism of miR-381 in the treatment of lung cancer remains unclear. miR-381 was downregulated in non-small-cell lung cancer tissues and cell lines, while USP39 was upregulated.
genetics_overexpression_suppress	36046374	hsa-mir-33a	Stomach Neoplasms	Overexpression of miR-33a-5p in BGC-823 and MGC-803 cells greatly inhibited the cell invasion and colony number.
exosome	36045954	hsa-mir-100	Wounds and Injuries	miR5p-enriched ADSC-Exos can be used to treat skin wound and expand EpSCs for generating epidermal autografts and engineered skin equivalents.
lncRNA target	36045666	hsa-let-7c	Pre-Eclampsia	CONCLUSIONS: The hsa-let-7c/IGF1R axis might affect the PI3K-Akt signaling pathway which is involved in the pathogenesis of PE, and inhibitors targeting this pathway might be used for PE treatment.
lncRNA target	36045665	hsa-mir-144	Glioma	TMP inhibits the proliferation, migration, and invasion of glioma cells by regulating the UBL7-AS1/miR
lncRNA target	36045598	hsa-mir-122	Lung Neoplasms	Reduced linc01555 refrained tumor growth and DDP resistance in vivo.In short, linc01555 may cause changes in DDP resistance via miR
lncRNA target	36045598	hsa-mir-122	Infant, Small For Gestational Age	Reduced linc01555 refrained tumor growth and DDP resistance in vivo.In short, linc01555 may cause changes in DDP resistance via miR
lncRNA target	36045408	hsa-mir-1322	Prostatic Neoplasms	CONCLUSIONS: CircSMARCC1 up-regulates the chemokine CCL20 secretion by sponging miR-1322, which is involved in the crosstalk between tumor cells and TAMs by targeting CCL20/CCR6 signaling to promote progression of PCa.
lncRNA target	36045396	hsa-mir-547	Neuralgia	MiR3p may be a key target of MT for anti-inflammatory and analgesia effects, which is achieved by mediating the Map4k4/NF-kappaB pathway to regulate downstream inflammatory cytokines.
lncRNA target	36045117	hsa-mir-145	Urinary Bladder Neoplasms	These findings not only provide a novel insight into the understanding association of autophagy induction with BC invasion inhibition by ISO, but also identify an upstream regulatory cascade, Dicer/miR145/SOX2/miR365a/RAC1, leading to MKK7/JNKs activation and autophagy induction.
lncRNA target	36045117	hsa-mir-365a	Urinary Bladder Neoplasms	These findings not only provide a novel insight into the understanding association of autophagy induction with BC invasion inhibition by ISO, but also identify an upstream regulatory cascade, Dicer/miR145/SOX2/miR365a/RAC1, leading to MKK7/JNKs activation and autophagy induction.
circulation_biomarker_diagnosis_down	36043754	hsa-mir-146	COVID-19	CONCLUSION: High viral load, increased blood level of ACE2, and down-regulation of micro-RNA 146 expression are associated with more severe lung injury and the presence of neurologic complications like convulsions and coma in COVID-19 Egyptian patients.
circulation_biomarker_diagnosis_ns	36043408	hsa-mir-106a	Multiple Sclerosis	RESULTS: The expression levels of miR-330, miR-106a, and miR125-b in blood samples of RRMS patients were predominantly reduced.
circulation_biomarker_diagnosis_ns	36043408	hsa-mir-30	Multiple Sclerosis	RESULTS: The expression levels of miR-330, miR-106a, and miR125-b in blood samples of RRMS patients were predominantly reduced.
other	36043408	hsa-mir-125b	Multiple Sclerosis	This study aimed to evaluate the miR-106a, miR-125b, and miR330- expression levels in relapsing-remitting multiple sclerosis (RRMS) patients.
transcription factor target	36043333	hsa-mir-454	Reperfusion Injury, Cerebral Ischemia	MiR-454 protected animals from brain injury induced by cerebral I/R via directly regulating its target gene NOX4, illustrating a curatively potential target for treating ischemic stroke.
lncRNA target	36043264	hsa-mir-204	Corneal Neovascularization	MiR-204 may be a potential therapeutic target in alkali burn-induced CNV.
circulation_biomarker_diagnosis_ns	36043143	hsa-mir-424	Carcinoma, Non-Small-Cell Lung	Furthermore, the predictive value of the P53 protein gene on the occurrence of BMS in NSCLC is analyzed by the ROC curve, and the expression of miR-424 in serum of the patients before and after drug resistance is compared.
exosome	36043050	hsa-mir-581	Gallbladder Neoplasms	Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p.
exosome	36043050	hsa-mir-4433a	Gallbladder Neoplasms	Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p.
exosome	36043050	hsa-mir-203b	Gallbladder Neoplasms	Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p.
exosome	36043050	hsa-mir-552	Gallbladder Neoplasms	Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p.
exosome	36043050	hsa-mir-496	Gallbladder Neoplasms	Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p.
other	36042613	hsa-mir-613	Atrial Fibrillation	3p-CXCR4 regulatory axis may be associated with the pathogenesis of AF.
other	36042613	hsa-mir-1207	Atrial Fibrillation	3p-CXCR4 regulatory axis may be associated with the pathogenesis of AF.
circulation_biomarker_diagnosis_up	36042375	hsa-mir-375	Prostatic Neoplasms, Castration-Resistant	Previously, we found that plasma exosomal miR-375 is significantly elevated in castration-resistant PCa (CRPC) patients compared with castration-sensitive PCa patients.
other	36042288	hsa-mir-133a	Disease	Our results suggest that controlled delivery of miR-133a-3p mimics, or antagomirs in diseased endothelial cells, might open new therapeutic interventions to treat patients suffering from cardiovascular pathologies that occur with excessive or insufficient angiogenesis.
other	36042288	hsa-mir-133a	Cardiovascular Diseases	Our results suggest that controlled delivery of miR-133a-3p mimics, or antagomirs in diseased endothelial cells, might open new therapeutic interventions to treat patients suffering from cardiovascular pathologies that occur with excessive or insufficient angiogenesis.
other	36042287	hsa-mir-573	Breast Neoplasms	LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates Breast cancer (BC) is considered the second commonest human carcinoma and the most incident and mortal in the female population. We finally identified LINC00511/hsa-miR-573 axis to be the most promising ncRNA-associated pathways that account for GSDMC in BRCA.
circRNA target	36042279	hsa-mir-4691	Urethral Stricture	Our results showed that circ_0047339 might promote the growth and fibrosis of urethral scar fibroblasts through miR5p/TSP-1 axis, thus promoting the development of urethral stricture.
circulation_biomarker_diagnosis_ns	36041701	hsa-mir-15b	familial multiple nevi flammei	SIGNIFICANCE: Circulating PVT1 may serve as a useful biomarker to distinguish between good versus poor CCC, as it is involved in orchestrating angiogenesis via the miR-15b-5p-AKT3 axis; it thus has potential as a target for treating ischemic disease.
circulation_biomarker_diagnosis_ns	36041701	hsa-mir-15b	Coronary Artery Disease	SIGNIFICANCE: Circulating PVT1 may serve as a useful biomarker to distinguish between good versus poor CCC, as it is involved in orchestrating angiogenesis via the miR-15b-5p-AKT3 axis; it thus has potential as a target for treating ischemic disease.
lncRNA target	36041665	hsa-mir-217	Intervertebral Disc Degeneration	Furthermore, in vivo experimental results confirmed the suppressive role of miR-217 shuttled by MSC-EVs in IVDD.
genetics_knock down_promote	36041411	hsa-mir-526b	Uterine Cervical Neoplasms	CONCLUSION: Circ_0002762 knockdown inhibited CC progression by regulating miR-526b-5p/HK2 axis, suggesting that circ_0002762 was a promising therapeutic strategy for CC.
lncRNA target	36041209	hsa-mir-154	Osteosarcoma	FGD5-AS1 may promote chemoresistance through WNT5A-induced autophagy by sponging miR
other	36041072	hsa-mir-124	Breast Neoplasms	These data suggest that a CPSF1-p62-miR3p signaling axis is responsible for reduced sensitivity of breast cancer to chemotherapy.
genetics_overexpression_promote	36040683	hsa-mir-25	Gastrointestinal Stromal Tumors	3p abrogated the tumor-initiating effects of METTL3 overexpression on GISTs.
lncRNA target	36040608	hsa-mir-146a	Spinal Cord Injuries	Overall, our findings initially highlighted that Nrf2 inhibited GSDMD-mediated microglia pyroptosis and accelerated SCI repair by repressing miR-146a.
lncRNA target	36040555	hsa-mir-185	Alzheimer Disease	5p was related to both education and depression, whose decreased expression pattern in AD patients was alleviated by education and enhanced by depression, and participates in Abeta generation and accumulation.
lncRNA target	36040387	hsa-mir-217	Inflammation	5p suppressed the activated STAT1-signal induced inflammation and oxidative stress trigged by PM2.5 in macrophages and resulted in the decreased lung injure caused by PM2.5.
other	36040381	hsa-mir-139	Breast Neoplasms	Moreover, The AC026401.3/CCNB1-miR5p axis was discovered as the most promising upstream ncRNA-related pathway of CCNB1 in BC.
lncRNA target	36039935	hsa-mir-9	Uterine Cervical Neoplasms	SOX21-AS1 was targeted by miR3p in CC cells.
genetics_overexpression_promote	36039933	hsa-mir-126	Squamous Cell Carcinoma of Head and Neck	5p mimic exerted suppressive functions in the progression of OSCC, which were neutralized after GAB1 overexpression.
lncRNA target	36039677	hsa-mir-99a	Hepatolenticular Degeneration	Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells.
lncRNA target	36039677	hsa-mir-99a	Muscular Atrophy	Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells. These data indicate that inhibition of MR activation with spironolactone prevented diet-induced abnormal expression of miR-99a, which had the capacity to reduce CD36, leading to reduced IMC lipid content and improved soleus mitochondria function and insulin sensitivity.
lncRNA target	36039677	hsa-mir-99a	Mitochondrial Diseases	Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells.
lncRNA target	36039677	hsa-mir-99a	Insulin Resistance	Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells.
lncRNA target	36039591	hsa-mir-21	Reperfusion Injury	MiRNA-21 promotes or inhibits autophagy via regulating relevant pathways for different downstream target genes, and plays a role in tumors, ischemia-reperfusion injury, and other diseases.
lncRNA target	36039578	hsa-mir-143	Glioma	miR-143 mimics and inhibitor were used to change the level of miR-143 in glioma cells. CONCLUSIONS: The up-regulated lncRNA SNHG14 can target miR-143, relieve the inhibition of miR-143 on MGMT, and promote the TMZ resistance in the hypoxia-induced glioma cells.
other	36039443	hsa-mir-5194	Stomach Neoplasms	Thus, the aim of this study was to understand the possible impact of transcriptional alterations and copy number variation (CNV) of four genes located in the 8q24.21 region - FAM49B, FAM84B, GSDMC and miR-5194 - in GC.
other	36039421	hsa-mir-205	Breast Neoplasms	5p-based therapy may expand the therapeutic opportunities for breast cancer.
other	36039421	hsa-mir-205	Drug Hypersensitivity	5p-based therapy may expand the therapeutic opportunities for breast cancer.
lncRNA target	36039405	hsa-mir-21	Neuralgia	These results indicated that Rh2 relieved SNI-induced neuropathic pain via inhibiting the miRNATLR8-MAPK signaling pathway, thus providing a potential application of Rh2 in pain therapy.
genetics_GWAS	36039054	hsa-mir-181b	Leukemia, Myeloid, Acute	In addition, miR-181b-5p expression was decreased in AML patients with the FLT3-ITD mutation (P=0.032) or WT1 mutation (P=0.017) when compared to AML patients without these genetic mutations.
other	36038907	hsa-mir-765	Carcinoma, Hepatocellular	RESULTS: lncRNA-AC079061.1, hsa-miR-765, and VIPR1 were identified as independent factors that affect the prognosis of hepatocellular carcinoma. Experimental results suggested that lncRNA-AC079061.1 and VIPR1 were frequently downregulated in HCC cells, while hsa-miR-765 was significantly upregulated.
target gene	36038837	hsa-mir-659	Osteosarcoma	MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1.
transcription factor target	36038535	hsa-mir-195	Alzheimer Disease	5p in AD pathogenesis and highlight several novel potentially relevant target mRNAs.
other	36037122	hsa-mir-130b	Carcinoma, Hepatocellular	RESULTS: miR-130b was significantly upregulated, whereas miR-125b was significantly downregulated in HCC patients compared with cirrhotic patients and healthy controls.
circulation_biomarker_diagnosis_up	36037122	hsa-mir-125b	Carcinoma, Hepatocellular	CONCLUSION: Plasma miR-130b and miR-125b may play a role in disease progression and development of HCC and may act as potential biomarkers for the diagnosis of HCC.
other	36037113	hsa-mir-133a	Uterine Neoplasms	This study aimed to elucidate whether some specific types of miRNAs (miRNA133-a, miRNA-21, miRNA-205) can act as prognostic or diagnostic biomarkers for endometrial carcinoma (ER) in Egyptian patients.
circulation_biomarker_prognosis_up	36037113	hsa-mir-205	Uterine Neoplasms	CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients.
circulation_biomarker_prognosis_up	36037113	hsa-mir-133a-2	Uterine Neoplasms	CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients.
circulation_biomarker_prognosis_up	36037113	hsa-mir-21	Uterine Neoplasms	CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients.
genetics_knock down_suppress	36036334	hsa-mir-188	Keloid	GNAS-AS1 knockdown could regulate the miR
circRNA target	36036266	hsa-mir-197	Carcinoma, Non-Small-Cell Lung	This work clarified the biological functions and molecular mechanisms of how hsa_circ_0003497 suppresses NSCLC through miR
lncRNA target	36035369	hsa-mir-21	Carcinoma, Renal Cell	Conclusions: Hsa-mir-21 predicted target genes (RP2, NFIA, SPRY1 and TGFBI) and the common transcription factor ZNF263 could be the advanced prognosis biomarkers in KIRC patients.
circRNA target	36035287	hsa-mir-589	Diabetic Retinopathy	5p targeted YAP1 and relieved HG-induced cell dysfunction via downregulating YAP1.
other	36035214	hsa-mir-181b	Atherosclerosis	3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS.
other	36035214	hsa-mir-350	Atherosclerosis	3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS.
other	36035214	hsa-mir-421	Atherosclerosis	3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS.
lncRNA target	36035170	hsa-mir-1224	Lumbosacral Spinal Root Avulsion	Functional analyses based on gene ontology and Kyoto Encyclopedia of Genes and Genomes predicted the potential roles of differentially expressed circRNAs and mRNAs in LSRA, and circRNA/miRNA/mRNA interaction networks revealed that circRNA_7025, a down-regulated circRNA in LSRA, was targeted by two neuronal apoptosis-related miRNAs, rno-miR-1224 and rno-miR5p.
circulation_biomarker_diagnosis_up	36035156	hsa-mir-1	Heart Septal Defects, Ventricular	3p upregulation in circulation is a direct and powerful indicator of fetal VSD and is expected to serve as a prenatal VSD diagnostic marker.
circulation_biomarker_diagnosis_up	36035154	hsa-mir-6785	psoriasis 1	Serum EVs miR-1305 and miR
circulation_biomarker_diagnosis_up	36035154	hsa-mir-1305	psoriasis 1	Serum EVs miR-1305 and miR
other	36035012	hsa-mir-4429	Rectal Prolapse	It was confirmed that miR-4429 interacted with PTEN messenger RNA (mRNA), and the expression level of miR-4429 was reduced in fibroblasts from the POP group or fibroblasts treated with AGEs. CONCLUSIONS: We proposed that AGEs induced fibroblast apoptosis by regulating the miR-4429/PTEN/PI3K/Akt pathway in POP.
other	36034978	hsa-mir-136	Osteosarcoma	CONCLUSIONS: The lncRNA CRNDE promotes the proliferation and migration of OS cells by regulating the miR5p/MRP9 pathway, and lncRNA CRNDE can be a significant marker of OS prognosis.
exosome	36034465	hsa-mir-129b	Femur Head Necrosis	CONCLUSIONS: MQEF can regulate exosomal miRNA expression in steroid-induced INFH models, miR3p or miR-129b-5p/PI3K-Akt signal axis may be part of the mechanism of MQEF against steroid-induced INFH.
exosome	36034465	hsa-mir-185	Femur Head Necrosis	CONCLUSIONS: MQEF can regulate exosomal miRNA expression in steroid-induced INFH models, miR3p or miR-129b-5p/PI3K-Akt signal axis may be part of the mechanism of MQEF against steroid-induced INFH.
other	36033831	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression.
other	36033831	hsa-mir-15b	Squamous Cell Carcinoma of Head and Neck	3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression.
other	36033831	hsa-mir-199a	Squamous Cell Carcinoma of Head and Neck	3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression.
other	36033831	hsa-mir-424	Squamous Cell Carcinoma of Head and Neck	3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression.
other	36033831	hsa-mir-454	Squamous Cell Carcinoma of Head and Neck	3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression.
genetics_overexpression_promote	36033827	hsa-mir-657	Carcinoma, Non-Small-Cell Lung	High levels of miR-657 were predictive of a poorer NSCLC patient prognosis, and overexpressing miR-657 resulted in the more rapid growth of NCI-H1650 and A549 cells, with a concomitant increase in their invasion.
other	36033494	hsa-mir-139	Adenocarcinoma of Lung	Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity.
other	36033494	hsa-mir-486	Adenocarcinoma of Lung	Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity.
other	36033494	hsa-mir-4732	Adenocarcinoma of Lung	Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity.
other	36033494	hsa-mir-451a	Adenocarcinoma of Lung	Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity.
lncRNA target	36033389	hsa-mir-146b	Breast Neoplasms	Therefore, we conclude that MEG3 positively modulates SLFN5 expression by sponging miR-146b-5p and inhibits breast cancer development.
lncRNA target	36033309	hsa-mir-342	Squamous Cell Carcinoma of Head and Neck	Finally, the results of in vivo models confirmed that SNHG20 promotes LSCC progression through modulating miR
lncRNA target	36032725	hsa-mir-21	Lung Neoplasms	Through the detection of miRNA-21, healthy people and lung cancer patients were distinguished, which verified the possibility of the application in clinical detection.
lncRNA target	36032150	hsa-mir-616	Melanoma	Through bioinformatics analysis, the OIP5-AS1-hsa-miR
lncRNA target	36032150	hsa-mir-23b	Melanoma	Through bioinformatics analysis, the OIP5-AS1-hsa-miR
lncRNA target	36032150	hsa-mir-374b	Melanoma	Through bioinformatics analysis, the OIP5-AS1-hsa-miR
lncRNA target	36032150	hsa-mir-135a	Melanoma	Through bioinformatics analysis, the OIP5-AS1-hsa-miR
lncRNA target	36032150	hsa-mir-186	Melanoma	Through bioinformatics analysis, the OIP5-AS1-hsa-miR
other	36032099	hsa-mir-451a	Acquired Immunodeficiency Syndrome	5p with the RPs.
other	36032099	hsa-mir-625	Acquired Immunodeficiency Syndrome	5p with the RPs.
other	36032099	hsa-mir-1180	Acquired Immunodeficiency Syndrome	5p with the RPs.
other	36032099	hsa-mir-62	Acquired Immunodeficiency Syndrome	5p with the RPs.
other	36032099	hsa-mir-144	Acquired Immunodeficiency Syndrome	5p with the RPs.
genetics_knock down_suppress	36030691	hsa-mir-326	Lung Diseases	CONCLUSION: CircESPL1 knockdown might attenuate LPS-caused lung cell injury by regulating the miR-326/ MAPK14 axis, providing useful insight for exploring a novel therapeutic approach for IP.
transcription factor target	36030655	hsa-mir-382	Depression, Postpartum	In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD.
transcription factor target	36030655	hsa-mir-182	Depression, Postpartum	In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD.
circRNA target	36030248	hsa-mir-335	Glioma	The glycolysis regulating enzyme ALDOA was regulated by circKIF4A through the mechanism of interactivity with miR
exosome	36030223	hsa-mir-6825	Colorectal Neoplasms	CONCLUSION: lnc-HOXB8-1:2 in exosomes derived from neuroendocrine differentiated CRC cells acted as a ceRNA competitively binding hsa-miR5p to upregulate CXCR3 expression and leading to TAM infiltration and M2 polarization, which promotes neuroendocrine differentiated CRC progression.
transcription factor target	36029808	hsa-mir-702	Diabetic Neuropathies	5p has a neuroprotective effect on DE, and this effect was achieved by inhibiting 12/15-LOX.
other	36029681	hsa-mir-21	Breast Neoplasms	Because miRNA-21 is over-expressed in cancer cells, it has been tested in total RNA samples isolated from cancer cell line (breast cancer cell line, MCF-7).
circulation_biomarker_diagnosis_ns	36029501	hsa-mir-21	Carcinoma, Renal Cell	Correlation of miRNA-21 and blood Cr levels with tumor infiltration and distant The object of this study was to explore the correlation analysis between miRNA-21 and blood Cr levels with tumor invasion and distant metastasis in renal cancer patients. It is concluded when renal cancer patients were tested, we found that miRNA-21 and blood Cr levels were abnormally increased, and the two had a certain correlation with renal cancer tumor invasion and distant metastasis, which showed a positive correlation.
transcription factor target	36029500	hsa-mir-497	Hypoxia	The experimental results of this study prove that miR-497 can alleviate the damage caused by hypoxia-reoxygenation of cardiomyocytes by regulating target genes BCL-2 and LC3B.
exosome	36029497	hsa-mir-103	Carcinoma, Hepatocellular	The purpose of this article is to investigate the role and mechanism of exosome microRNA-103 in hepatocellular carcinoma cell proliferation and invasion.
lncRNA target	36029493	hsa-mir-218	Glioma	This study aimed to discover the molecular mechanism of mir-218 targeting the regulation of robol expression on proliferation, invasion and migration of glioma cells and to provide a theoretical and experimental basis for finding therapeutic targets of glioma.
other	36029367	hsa-mir-200	Neurodegenerative Diseases	Synergistic Effect of miR-200 and Young Extracellular Matrix-based Bio-scaffolds Aging is defined as a complex, multifaceted degenerative process that causes a gradual decline of physiological functions and a rising mortality risk with time.
genetics_overexpression_promote	36029292	hsa-mir-143	Inflammatory Bowel Diseases	In UC rats, cycloastragenol significantly reduced expression levels of SphK, MIP-1alpha, BAX, NF-kappaB, TNF-alpha and active caspase-3, associated with BCL2 and miR-143 overexpression.
lncRNA target	36029209	hsa-mir-637	Carcinoma, Hepatocellular	CONCLUSION: Circ_SNX27 contributed to HCC development via miR-637/FGFR1 axis, offering a new idea for the treatment of HCC.
other	36029069	hsa-mir-16	Adenocarcinoma of Lung	The present findings support further investigation of the anti-cancer effect of miR-16 in animal models of lung cancer to validate the therapeutic potential.
other	36028828	hsa-mir-146a	Diffuse Alveolar Hemorrhage, Autoimmune-Mediated	CONCLUSIONS: Our results demonstrate firstly down-regulated pulmonary miR-146a levels with increased TRAF6 and IL-8 expression and NETs and apoptosis formation in autoimmune-mediated DAH, and implicate a therapeutic potential of intra-pulmonary miR-146a delivery.
transcription factor target	36028821	hsa-mir-1248	Colorectal Neoplasms	CONCLUSION: Hsa-miR-1248 may act as a tumor suppressor gene in CRC by targeting and inhibiting PSMD10, which provides a clue for CRC treatment.
other	36028080	hsa-mir-490	Cardiotoxicity	In summary, miR5p and its downstream genes, SNAP91 and LYPD6 are associated with PFOA-induced developmental cardiotoxicity in chicken embryo, which might help to further elucidate the mechanism of PFOA-induced developmental cardiotoxicity.
other	36028011	hsa-mir-134	Bipolar Disorder	3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD.
other	36028011	hsa-mir-652	Bipolar Disorder	3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD.
other	36028011	hsa-mir-15b	Bipolar Disorder	3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD.
other	36028011	hsa-mir-155	Bipolar Disorder	3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD.
circulation_biomarker_diagnosis_up	36027941	hsa-mir-210	Ischemic Stroke	The results showed 1) H/R induced apoptosis and ROS overproduction in neurons; 2) miR-210 mimic increased the level of miR-210 in both EPCs and EPC-EXs; 3) EPCs cultured in serum-free medium released more exosomes in comparison with cells grown in complete growth media, suggesting serum starving induce the release of EXs; 4) After transfection, EPCs grown in complete media had almost 50 times higher miR-210 level than EPCs had in serum-free media, while the EPCs-EXs isolated from the complete media has lower miR-210 expression than from the serum-free media in a time-dependent manner, suggesting the transfer of miR-210 through EXs; 5) After co-incubation, EPC-EXs and miR210-EPC-EXs were uptaken by neurons, and the miR-210 level in neurons was elevated by miR210-EPC-EXs; 6) miR210-EPC-EXs were more effective in promoting cell viability and decreasing apoptosis and ROS production than EPC-EXs.
genetics_knock down_promote	36027936	hsa-mir-577	Breast Neoplasms	Finally, the rescuing experiments evidenced that both POSTN knockdown and ILK/Akt/mTOR pathway inhibitor OSU-T315 abrogated the promoting effects of miR-577 ablation on the malignant phenotypes in BC.
exosome	36027869	hsa-mir-181c	Carcinoma, Ovarian Epithelial	Extracellular vesicle-packaged miR-181c-5p from epithelial ovarian cancer cells OBJECTIVES: The molecular mechanistic actions of tumor-derived extracellular vesicles (EVs) in modulating macrophage polarization in the tumor microenvironment of epithelial ovarian cancer (EOC) is largely unknown.
lncRNA target	36027040	hsa-mir-124	Ischemic Stroke, Diabetic	In this study we assessed the association of the lncRNA Nuclear enriched abundant transcript 1 (NEAT1)'s expression and its target miRNA-124 with acute ischemic stroke (AIS) in type II diabetic patients (T2DM). In comparison to the AIS-only patients, DM patients and controls, miR-124 expression was considerably lower in the DM+AIS group.
genetics_overexpression_promote	36027039	hsa-mir-504	Carcinoma, Non-Small-Cell Lung	Overexpression of miR
other	36018564	hsa-mir-597	Myelodysplastic Syndromes	CONCLUSION: These findings suggest that upregulation of miR-597 induces apoptosis and that miR-597 has a possible role in the pathophysiology of MDS.
target gene	36018563	hsa-mir-378a	Graves Disease	hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth.
genetics_knock down_suppress	36018460	hsa-mir-582	Uterine Cervical Neoplasms	In summary, circ_0042986 overexpression decoyed miR
exosome	36018423	hsa-mir-29b	Aortic Diseases	By exosomal microRNA microarray analysis, we found that microRNA-29b was significantly reduced in aortic endothelial cells (AECs) receiving TAC. By contrast, antagonizing miR-29b in vivo further enhanced TAC-induced expressions of MMP12 and osteopontin, aggravated aortic fibrosis, calcification, and stiffness.
exosome	36018423	hsa-mir-29b	Diarrhea 5, With Tufting Enteropathy, Congenital	By exosomal microRNA microarray analysis, we found that microRNA-29b was significantly reduced in aortic endothelial cells (AECs) receiving TAC. By contrast, antagonizing miR-29b in vivo further enhanced TAC-induced expressions of MMP12 and osteopontin, aggravated aortic fibrosis, calcification, and stiffness.
exosome	36018178	hsa-mir-23b	Cerebral Hemorrhage	These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH.
exosome	36018178	hsa-mir-23b	Syphilis	These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH.
exosome	36018063	hsa-mir-130b	Acute Lung Injury	The present study was performed to elucidate the miR-130b-3p-involved mechanism in acute lung injury (ALI) through delivery by mesenchymal stem cells-derived exosomes (MSCs-Exo).
lncRNA target	36017918	hsa-mir-335	Urinary Bladder Neoplasms	5p to regulate the expression of downstream target gene IER2, forming a complete PCAT19/miR
genetics_overexpression_suppress	36017917	hsa-mir-1252	Stomach Neoplasms	Overexpression of THUMPD3-AS1 inhibits proliferation, migration, invasion and ROS accumulation of gastric cancer cells by regulation of miR3p and CXCL17.
genetics_overexpression_promote	36017916	hsa-mir-29c	lung squamous cell carcinoma	LSCC cells H1581 and H1993 were transfected with PLAC2 and cyclin-dependent kinase 6 (CDK6) expression vectors and small interfering RNAs (siRNAs), as well as microRNA-29C (miR-29C) mimic and inhibitor to perform overexpression and knock-down experiment, respectively.
circRNA target	36017914	hsa-mir-485	Colorectal Neoplasms	5p, as the target of circHIPK2 in CRC model, played a role in promoting CRC progression and expediting HSP90 ubiquitination.
genetics_overexpression_promote	36017912	hsa-mir-587	Urinary Bladder Neoplasms	miR-587 has been shown to be a target of PGM5-AS1, and miR-587 overexpression can reverse the inhibitory effect of PGM5-AS1 upregulation on BC cell growth.
genetics_overexpression_promote	36017911	hsa-mir-21	Neuroblastoma	PCAT29 overexpression promoted NB cell apoptosis, while miR-21 overexpression inhibited NB cell apoptosis and attenuated PCAT29 overexpression-mediated NB cell apoptosis.
other	36017856	hsa-mir-1324	Carcinoma, Hepatocellular	CONCLUSION: Circ_0006789 modulates the growth, migration and invasion of HCC cells by regulating miR-1324/SOX12 axis.
other	36017689	hsa-mir-742	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-742	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-22	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-298	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-568	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-542	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-542	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-568	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-298	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-376b	Vascular Calcification	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-22	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017689	hsa-mir-376b	Renal Insufficiency, Chronic	5p were significantly reduced at both 4 and 16 weeks.
other	36017315	hsa-mir-652	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-mir-1303	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-mir-571	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-mir-661	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-mir-892b	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-mir-770	Diabetes Mellitus, Type 2	3p.
other	36017315	hsa-let-7e	Diabetes Mellitus, Type 2	3p.
genetics_overexpression_promote	36017148	hsa-mir-96	Adenocarcinoma of Lung	Overexpression of miR5p suppressed FHL1 expression in LUAD cells and promoted proliferation, invasion, and migration of LUAD cells, while overexpression of FHL1 could simultaneously restore the above-mentioned promoting effect.
other	36016920	hsa-mir-34a	Chronic Periodontitis	CONCLUSION: There is an abnormally high expression of miR-34a in GCF of chronic periodontitis.
other	36016885	hsa-mir-181	Mucocutaneous Lymph Node Syndrome	The miR-181 family contributes to the pathogenesis of cardiovascular and inflammatory disorders, while Nanos3 is involved in DNA transcription regulation and cell proliferation.
genetics_GWAS	36016885	hsa-mir-181c	Mucocutaneous Lymph Node Syndrome	CONCLUSION: SNP rs8108402 C/T located in the miR-181c/d promoter and Nanos3 intronic region is associated with susceptibility to Kawasaki disease but not with the development of coronary artery lesions or IVIG unresponsiveness in Chinese children.
genetics_GWAS	36016885	hsa-mir-181d	Mucocutaneous Lymph Node Syndrome	CONCLUSION: SNP rs8108402 C/T located in the miR-181c/d promoter and Nanos3 intronic region is associated with susceptibility to Kawasaki disease but not with the development of coronary artery lesions or IVIG unresponsiveness in Chinese children.
lncRNA target	36016863	hsa-mir-24	Digestive System Neoplasms	3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression.
lncRNA target	36016863	hsa-mir-15	Endocrine Gland Neoplasms	3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression.
lncRNA target	36016863	hsa-mir-24	Endocrine Gland Neoplasms	3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression.
lncRNA target	36016863	hsa-mir-15	Digestive System Neoplasms	3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression.
lncRNA target	36016851	hsa-mir-184	Carcinoma, Non-Small-Cell Lung	In a word, this study indicated that circCNN2 activated MAPK signaling pathway through the miR-184/E2F1 axis to promote proliferation and invasion of LUSC cells.
genetics_GWAS	36016604	hsa-mir-671	Sarcoma	The results showed that miR-671 rs1870238 GC CC (OR = 1.963, 95% CI = 1.258-3.064, P = 0.003) and miR-671 rs2446065 CG GG (OR =1.838, 95% CI = 1.178-2.868, P = 0.007) may be genetic risk factors for STSs after adjustment for age and smoking. Therefore, this study suggests that individuals carrying the GC CC genotype for miR-671 rs1870238 or the CG GG genotype for miR-671 rs2446065 are susceptible to STSs.
lncRNA target	36016581	hsa-mir-942	Squamous Cell Carcinoma of Head and Neck	5p/HSPD1 axis is a potential target for OSCC.
lncRNA target	36016468	hsa-mir-148b	Ovarian Neoplasms	Most importantly, the si-LINC00665 could reverse the promotion effect of the miR-148b-3p inhibitor on the malignant biological behavior of OC cells.
transcription factor target	36014967	hsa-mir-155	Stomach Neoplasms	5p could be a therapeutic target for GC related to CagA.
circulation_biomarker_diagnosis_up	36014577	hsa-mir-21	Lung Neoplasms	Exosomal MicroRNA-21 (miRNA-21, miR-21) is significantly up-regulated in blood samples of patients with lung cancer.
other	36013894	hsa-mir-132	Pancreatic Carcinoma	In this work, the presence of a specific pancreatic cancer-derived miRNA (pre-miR-132) is detected using the fluorescence properties of biocompatible nitrogen-doped graphene quantum dots (NGQDs) synthesized using a bottom-up approach from a single glucosamine precursor.
other	36012644	hsa-mir-223	Pulmonary Fibrosis	We showed that ectopic expression of miR-223 in HSCs attenuated fibrogenesis in the two human organoid models of liver injury, suggesting its potential application in antifibrotic therapy.
other	36012644	hsa-mir-233	Pulmonary Fibrosis	Finally, to explore the therapeutic potential of miR-233 in liver fibrosis, we generated co-cultured organoids of HSCs with Huh7 hepatoma cells and challenged them with acetaminophen (APAP) or palmitic acid (PA) to induce hepatotoxicity.
other	36012644	hsa-mir-233	Liver Injury	Finally, to explore the therapeutic potential of miR-233 in liver fibrosis, we generated co-cultured organoids of HSCs with Huh7 hepatoma cells and challenged them with acetaminophen (APAP) or palmitic acid (PA) to induce hepatotoxicity.
other	36012644	hsa-mir-223	Liver Injury	We showed that ectopic expression of miR-223 in HSCs attenuated fibrogenesis in the two human organoid models of liver injury, suggesting its potential application in antifibrotic therapy.
lncRNA target	36012615	hsa-mir-145	Cystic Fibrosis	Targeting of miR
lncRNA target	36012615	hsa-mir-101	Cystic Fibrosis	Targeting of miR
lncRNA target	36012615	hsa-mir-335	Cystic Fibrosis	Targeting of miR
lncRNA target	36012303	hsa-let-7d	Pulmonary Fibrosis	In silico analysis revealed COL3A1 and SMAD2, proteins involved in the development of IPF, as Let-7d targets.
transcription factor target	36011411	hsa-mir-18a	Glaucoma	Together, these findings identify miR-18a-5p as a mediator of the TGFbeta2 response and a candidate therapeutic agent for glaucoma via its ability to inhibit CTGF-associated increased TM contractility.
transcription factor target	36011378	hsa-mir-107	Lipid Metabolism Disorders	Moreover, for the highly conserved among different species, miR-107 may be a potential molecular target to be used for the treatment of lipid-related diseases in the future.
epigenetics	36011313	hsa-mir-203	Lymphoma, Large B-Cell, Diffuse	The methylation frequencies of the MIR
epigenetics	36011313	hsa-mir-129-2	Lymphoma, Large B-Cell, Diffuse	The methylation frequencies of the MIR
epigenetics	36011313	hsa-mir-34b	Lymphoma, Large B-Cell, Diffuse	The methylation frequencies of the MIR
epigenetics	36011313	hsa-mir-34a	Lymphoma, Large B-Cell, Diffuse	The methylation frequencies of the MIR
lncRNA target	36011286	hsa-mir-23b	Carcinoma, Hepatocellular	CONCLUSION: Our study highlights the cytoprotective role of autophagy and glutamine addiction modulated by miR-23b-3p (tumor suppressor), suggesting new approaches to curb sorafenib resistance in HCC.
other	36010613	hsa-mir-7	Alzheimer Disease	We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway.
other	36010613	hsa-mir-7	Diabetes Mellitus, Type 2	We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway.
other	36010581	hsa-mir-29c	Atrophy	Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery.
other	36010581	hsa-mir-137	Atrophy	Autophagy-related 2A, F-box and WD repeat domain containing 7, F-box only protein 32, miR-137, and miR-153 showed exceptional high expression suggesting them as master regulators of muscle atrophy.
other	36010581	hsa-mir-1	Atrophy	Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery.
other	36010581	hsa-mir-206	Atrophy	Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery.
other	36010581	hsa-mir-27a	Atrophy	Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery.
other	36010581	hsa-mir-153	Atrophy	Autophagy-related 2A, F-box and WD repeat domain containing 7, F-box only protein 32, miR-137, and miR-153 showed exceptional high expression suggesting them as master regulators of muscle atrophy.
other	36010296	hsa-mir-146a	ST Elevation Myocardial Infarction	3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction.
other	36010296	hsa-mir-223	ST Elevation Myocardial Infarction	3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction.
other	36010296	hsa-mir-142	ST Elevation Myocardial Infarction	3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction.
other	36010264	hsa-mir-148b	Cognition Disorders	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
other	36010264	hsa-mir-7a	Multiple Sclerosis	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
other	36010264	hsa-mir-7a	Cognition Disorders	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
other	36010264	hsa-mir-7b	Multiple Sclerosis	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
other	36010264	hsa-mir-7b	Cognition Disorders	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
other	36010264	hsa-mir-148b	Multiple Sclerosis	Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction.
circulation_biomarker_diagnosis_up	36010252	hsa-mir-146a	Liver Cirrhosis	These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients.
circulation_biomarker_diagnosis_up	36010252	hsa-mir-146a	Schistosomiasis	These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients.
other	36009855	hsa-mir-21	Jaundice, Acute	MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05).
other	36009855	hsa-mir-133a	Jaundice, Acute	MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05).
other	36009855	hsa-mir-122	Jaundice, Acute	MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05).
other	36009075	hsa-mir-516b	Glioblastoma	Conclusions The OSMR-AS1/ miR-516b-5p axis was identified as the highest-potential upstream ncRNA-related pathway of H6PD in GBM.
circulation_biomarker_diagnosis_ns	36009063	hsa-mir-3123	Ischemic Stroke	Serum microRNA miR
circulation_biomarker_diagnosis_ns	36009063	hsa-mir-206	Ischemic Stroke	Higher serum miR-206 level independently increased the risk of spontaneous HT in AIS patients.
circulation_biomarker_diagnosis_ns	36009063	hsa-mir-21	Ischemic Stroke	Serum microRNA miR
circulation_biomarker_diagnosis_ns	36009063	hsa-mir-491	Ischemic Stroke	Serum microRNA miR
circulation_biomarker_diagnosis_ns	36009038	hsa-mir-135a	Endometriosis	This indicates that hsa-mir-135a is a putative noninvasive biomarker of endometriosis in both saliva and plasma, but further validation studies are required to assess its clinical value as a biomarker.
other	36009031	hsa-mir-449b	Brain Ischemia	Our study showed that LRIC promoted the proliferation and migration of neural stem cells after MCAO, and these effects were modulated by the miR-449b/Notch1 pathway.
genetics_overexpression_promote	36008842	hsa-mir-1254	Uterine Cervical Neoplasms	CD36 overexpression reversed the inhibitory effects of upregulated miR-1254 in the cervical cancer cells, suggesting that miR-1254 regulates cervical cancer progression by modulating CD36.
lncRNA target	36008700	hsa-mir-497	Carcinoma, Hepatocellular	5p played a tumor-inhibitory role in HCC cells by targeting ANXA11.
circRNA target	36008392	hsa-mir-6820	Carcinoma, Pancreatic Ductal	In conclusion, our findings reveal that hsa_circ_0007367 acts as an oncogene via modulating miR
genetics_overexpression_promote	36008375	hsa-mir-10b	Squamous Cell Carcinoma of Head and Neck	Overexpression of miR-10b was followed by enhanced OSCC invasion and migration and activated autophagic protein, such as LC3II/ATG5.
exosome	36007833	hsa-mir-122	Osteoarthritis	We concluded that OA-Exos may, through the miR-122/HO-1 pathway, reduce immune function and antioxidant defence in CIK cells.
other	36007832	hsa-mir-750	Lichen Sclerosus et Atrophicus	Penaeus monodon miR-750 (pmo-miR-750) was found to be strongly up-regulated in the late phase of white spot syndrome virus (WSSV) infection, but its function remains uncharacterized.
lncRNA target	36007832	hsa-mir-750	Werner Syndrome	Collectively, our findings reveal that up-regulated pmo-miR-750 suppresses Scp expression at both the transcript and protein levels in the late stage of WSSV infection, which contributes to modulating apoptosis and eventually enabling viral propagation.
transcription factor target	36007337	hsa-mir-767	Melanoma	3p was shown to inhibit ASF1B which will attenuate melanoma tumorigenesis, and by this it can be a potential new effective biomarker for the treatment of melanoma.
transcription factor target	36006565	hsa-mir-223	Brain Ischemia	Further, miR3p resulted in the decreased cell viability and glucose uptake and the increased cell apoptosis to cause ischemic brain damage.
exosome	36006542	hsa-mir-342	Venous Thrombosis	3p loaded by hucMSCs-exos attenuates DVT by downregulating EDNRA, offering a novel direction to treat DVT.
circulation_biomarker_diagnosis_ns	36006370	hsa-mir-155	Atherosclerosis	Moreover, detection of circulating EVs-carried miR-155 expression may reveal the progression of atherosclerosis. On the molecular level, blocking miR-155 biogenesis, which constituted a novel therapeutic approach, may protect against nicotine aggravating atherosclerosis.
circulation_biomarker_diagnosis_ns	36006370	hsa-mir-155	limb ischemia	Moreover, detection of circulating EVs-carried miR-155 expression may reveal the progression of atherosclerosis. On the molecular level, blocking miR-155 biogenesis, which constituted a novel therapeutic approach, may protect against nicotine aggravating atherosclerosis.
transcription factor target	36005571	hsa-mir-1	Hypothermia	Furthermore, transcriptional expression of key genes demonstrates hypothermia-activated AMPK signaling by miR-1 and subsequently inhibited the downstream glucogenic and glycogenic gene expression and gene expression of fatty acid synthesis. In conclusion, these results suggest that miR-1/AMPK is an important target for chronic hypothermia control.
other	36005478	hsa-mir-199a	Stomach Neoplasms	Our findings point toward the critical role of CAFs-derived EVs carrying miR-199a-5p in gastric cancer progression.
genetics_overexpression_promote	36004693	hsa-mir-576	Colonic Neoplasms	5p overexpression notably facilitated the proliferative, migratory, invasive abilities of colon adenocarcinoma cells.
transcription factor target	36004692	hsa-mir-944	Carcinoma, Hepatocellular	Our study demonstrated that ciRS-7 enhanced the proliferation, migration, and invasion of HCC through miR-944/NOX4 pathway.
genetics_overexpression_promote	36004691	hsa-mir-25	Thyroid Cancer, Papillary	miR-25 overexpression increased PTC cell proliferation.
lncRNA target	36004648	hsa-mir-214	Osteosarcoma	5p/SOX4 feedback loop performs an important role in OS progression and might be used as a new potential therapeutic target for the treatment of OS.
other	36004563	hsa-mir-449c	Carcinoma, Hepatocellular	Here, we found that ACOT9 expression is significantly elevated in HCC at least partially due to the down-regulation of miR-449c-3p.
genetics_knock down_promote	36004524	hsa-mir-433	Multiple Myeloma	3p downregulation or PBX3 overexpression reversed the inhibition effect of circ_0003489 knockdown on MM progression.
genetics_knock down_promote	36004511	hsa-mir-186	Leukemia, Myeloid, Acute	5p expression weakened circ_0044907 knockdown mediated suppression on AML cell viability, proliferation, and cycle progression.
other	36004323	hsa-mir-223	Chagas Cardiomyopathy	5p with CCM worsening.
lncRNA target	36003920	hsa-mir-29b	Lung Neoplasms	CONCLUSION: The results of this study indicate that miR-29b inhibits the proliferation and deterioration of NSCLC cells by targeting FEM1B and inhibiting the activation of the FOXO1/AKT pathway.
circulation_biomarker_diagnosis_ns	36003409	hsa-mir-23a	Osteoarthritis	The different temporal expressions of seven microRNAs in plasma and synovial fluid-derived extracellular vesicles, eca-miR-451, eca-miR-25, eca-miR-215, eca-miR-92a, eca-miR-let-7c, eca-miR5p, and eca-miR-23a, and four snoRNAs, U3, snord15, snord46, and snord58, represent potential biomarkers for early osteoarthritis.
other	36003405	hsa-let-7b	Uveal melanoma	Furthermore, LINC00665/hsa-let-7b-5p/RBM15B axis and LINC00638/hsa-miR-103a-3p/RBM15B axis were found to be potential prognostic biomarkers in UM.
other	36003405	hsa-mir-103a	Uveal melanoma	Furthermore, LINC00665/hsa-let-7b-5p/RBM15B axis and LINC00638/hsa-miR-103a-3p/RBM15B axis were found to be potential prognostic biomarkers in UM.
other	36003338	hsa-mir-200a	Urinary Bladder Neoplasms	Meanwhile, we identified lncRNA OCIAD1-AS1/miR3p/GPM6B and lncRNA OCIAD1-AS1/miR-200a-3p/AKAP11 regulatory axes, which may play a potential role in the progression of BC.
other	36003338	hsa-mir-141	Urinary Bladder Neoplasms	Meanwhile, we identified lncRNA OCIAD1-AS1/miR3p/GPM6B and lncRNA OCIAD1-AS1/miR-200a-3p/AKAP11 regulatory axes, which may play a potential role in the progression of BC.
transcription factor target	36003288	hsa-mir-204	Neuralgia	CONCLUSION: These results suggested that miR5p may alleviate neuropathic pain and inflammation through targeted regulation of BRD4 expression.
transcription factor target	36003151	hsa-mir-202	Pathologic Processes	Transcriptome comparison revealed >250 RNAs including both maternal and zygotic origins were dysregulated at MBT in the miR-202(-/-) embryos, corresponding with arrays of homeostatic disorders leading to massive apoptosis.
other	36003065	hsa-mir-210	Epilepsy	METHODS: In a pilocarpine-induced epileptic rat model, the expressions of microRNA-210 (miR-210), TLR4, NF-kappaB1 and caspase-3 were assessed by a quantitative polymerase chain reaction and Western blotting.
lncRNA target	36003065	hsa-mir-210	Seizures	This study aimed to determine whether microRNA-210 regulates seizure and apoptosis by targeting the TLR4 /NF-kappaB1 associated signaling pathway.
lncRNA target	36003063	hsa-mir-206	Carcinoma, Hepatocellular	In conclusion, our results revealed that miR-206 could down-regulate the expression of CREB5 and inhibit the activation of PI3K/AKT signaling pathway, thereby preventing HCC growth and metastasis.Abbreviations: HCC: hepatocellular carcinoma; HBV or HCV: hepatitis B or C virus; miRNAs: microRNAs; CREB: cAMP response element-binding protein; CRE: cAMP response elements.
genetics_knock down_promote	36002666	hsa-mir-495	Cataract, Age-Related	3p overexpression or HDAC4 knockdown reversed the inhibition effect of circ_HIPK3 on H(2)O(2)-induced lens epithelial cell injury.
genetics_overexpression_promote	36002606	hsa-mir-200	Carcinoma, Non-Small-Cell Lung	In conclusion, PFD-induced miR-200 overexpression in CAFs inhibits ZEB1 expression in NSCLC cells, and thus decelerates the migration, invasion and EMT process.
genetics_GWAS	36002591	hsa-mir-128a	Diabetic Neuropathies	CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN.
genetics_GWAS	36002591	hsa-mir-146a	Diabetes Mellitus, Type 1	CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN.
genetics_GWAS	36002591	hsa-mir-146a	Diabetic Neuropathies	CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN.
genetics_GWAS	36002591	hsa-mir-128a	Diabetes Mellitus, Type 1	CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN.
other	36002186	hsa-mir-21	Lung Neoplasms	Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo.
other	36002186	hsa-mir-21	Breast Neoplasms	Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo.
other	36002186	hsa-mir-21	Head and Neck Neoplasms	Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo.
lncRNA target	36002076	hsa-mir-620	Thyroid Neoplasms	Furthermore, IRF2BP2 was discovered to be a target of miR-620, which displayed low expression in THCA cells and tissues.
lncRNA target	36001751	hsa-mir-130b	Obesity	Together, these data identify the miR-130b/301b cluster as a new regulator that suppresses beige adipogenesis involving PGC-1alpha and AMPK signaling in iWAT and is therefore a potential therapeutic target against obesity and related metabolic disorders.
lncRNA target	36001751	hsa-mir-130b	Metabolic Diseases	The miRNA cluster miR-130b/301b is highly expressed in adipose tissues and has been implicated in metabolic diseases as a posttranscriptional regulator of mitochondrial biogenesis and lipid metabolism. Together, these data identify the miR-130b/301b cluster as a new regulator that suppresses beige adipogenesis involving PGC-1alpha and AMPK signaling in iWAT and is therefore a potential therapeutic target against obesity and related metabolic disorders.
other	36001412	hsa-mir-192	Cell Transformation, Neoplastic	Pearson's correlations revealed positive association between miR-192 expression and E-cadherin and Bax/Bcl2 as well, and it was negatively correlated to alpha-fetoprotein, NF-kappaB and TGF-beta and the cellular atypia score.
lncRNA target	36001412	hsa-mir-192	Carcinoma, Hepatocellular	Suppressed hepatic miR-192 and E-cadherin expression were detected in the HCC (DENA-CCL4) group accompanied by elevated tumor necrosis factor (TNF-alpha), interleukin (IL6)/NF-kappaB & TGF-beta1.
genetics_overexpression_promote	36001230	hsa-mir-488	Liver Cirrhosis	TET3 inhibition induced by the overexpression of miR
exosome	36001206	hsa-mir-214	Osteoarthritis	3p exosomes in treating OA.
exosome	36001206	hsa-mir-214	Inflammation	3p exosomes in treating OA.
other	36001185	hsa-mir-326	Breast Neoplasms	Circ_0008717 Sponges miR-326 to Elevate GATA6 Expression to Promote Breast Cancer Tumorigenicity.
other	36001113	hsa-mir-18a	Liver Cirrhosis	Meanwhile, UCA1 could competitively bind with miR18a to stabilize Smad3 to constitute a positive feedback pathway, which played a significant role in the promotion of liver fibrosis. UCA1 can competitively bind with miR18a, promote liver fibrosis by stabilizing Smad3, and form a UCA1-miR18a/Smad3 positive feedback.
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-144	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-133a	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-21	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-1	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-128	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
circulation_biomarker_diagnosis_ns	36000352	hsa-mir-206	Muscular Dystrophy, Duchenne	Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR
lncRNA target	36000339	hsa-mir-186	Postoperative Cognitive Complications	CONCLUSION: OIP5-AS1 plays a neuroprotective role in elderly POCD rats through sponging miR
transcription factor target	36000159	hsa-mir-106a	Asthma	After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls.
transcription factor target	36000159	hsa-mir-375	Asthma	After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls.
transcription factor target	36000159	hsa-mir-18a	Asthma	After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls.
transcription factor target	36000159	hsa-mir-144	Asthma	After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls.
other	35999259	hsa-mir-145	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy.
other	35999259	hsa-mir-708	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy.
other	35999259	hsa-mir-150	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy.
exosome	35999213	hsa-mir-1290	Prostatic Neoplasms	Cancer associated fibroblasts secreted exosomal miR-1290 contributes to prostate cancer cell growth and metastasis via targeting GSK3beta.
genetics_GWAS	35999071	hsa-mir-335	Hemorrhage	5p both could down-regulate dentin sialophosphoprotein expression, and both miRNAs could inhibit IGFBP7-AS1-mediated SHED odontogenetic differentiation via suppression of the extracellular signal-regulated kinase (ERK) pathway.
genetics_GWAS	35999071	hsa-mir-155	Hemorrhage	5p both could down-regulate dentin sialophosphoprotein expression, and both miRNAs could inhibit IGFBP7-AS1-mediated SHED odontogenetic differentiation via suppression of the extracellular signal-regulated kinase (ERK) pathway.
transcription factor target	35998789	hsa-mir-4813	Parkinson Disease	miR3p modulates ER(UPR), MT(UPR), autophagosome-lysosomal-pathway and the ubiquitin-proteasomal-system, making this molecule an interesting target for further studies towards therapeutically addressing multifactorial aspect of Parkinson's disease.
lncRNA target	35998761	hsa-mir-224	Esophageal Squamous Cell Carcinoma	5p/CPEB3 suppresses ESCC progression by inactivating EGFR/PI3K/AKT signaling, providing a basis for developing circ_0007624-targeted therapies for ESCC patients.
other	35998511	hsa-mir-19a	Diabetes Mellitus, Type 2	To assess the sensitivity and specificity of miR-19a and miR-221 expression as potential biomarkers for MI, the receiver operating characteristic curve (ROC) analysis was conducted for both diabetic groups. RESULTS: The diabetic MIDMet group exhibited a significant decrease in the expression levels of miR-221 (7.2 folds) and miR-19a (5.3 folds) as compared to the MIDMet- and MIND groups (p < 0.05).
other	35998511	hsa-mir-221	Diabetes Mellitus, Type 2	To assess the sensitivity and specificity of miR-19a and miR-221 expression as potential biomarkers for MI, the receiver operating characteristic curve (ROC) analysis was conducted for both diabetic groups. RESULTS: The diabetic MIDMet group exhibited a significant decrease in the expression levels of miR-221 (7.2 folds) and miR-19a (5.3 folds) as compared to the MIDMet- and MIND groups (p < 0.05).
other	35998503	hsa-mir-612	Thyroiditis, Autoimmune	mediated BRD4 expression.
lncRNA target	35998476	hsa-mir-155	Liver Injury	Here, we established a model of arsenic-induced chronic liver injury by providing rats with drinking water containing different concentrations of sodium arsenite (NaAsO(2)) and found that NaAsO(2) exposure decreased the mRNA and protein levels of AUF1 and the protein level of SOD1 and elevated the mRNA and protein levels of Dicer1 and miR-155 and the mRNA level of SOD1. A dual-luciferase reporter assay indicated that miR-155 decreased the mRNA and protein levels of SOD1 by targeting the SOD1 3'UTR, resulting in liver injury.
circulation_biomarker_diagnosis_ns	35998435	hsa-mir-34c	Adenocarcinoma, Sinonasal Intestinal	METHODS: MiR-34c-3p, lncRNA AF147447 and MUC2 were measured in tumors and normal mucosa, in nasal washings (NW) from the affected and non-affected nostril and in plasma from 17 ITAC patients.
genetics_knock down_promote	35998226	hsa-mir-17	Urinary Bladder Neoplasms	The exosomes derived from PTENP1-overexpressing BMSC (BMSC(OE-PTENP1)-Exo) abolished the promotive effects of miR-17 overexpression or SCARA5 knockdown on the malignant phenotypes of BC cells.
transcription factor target	35998069	hsa-mir-574	Colitis	CONCLUSIONS: Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR5p/CARD3-dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy.
circulation_biomarker_diagnosis_ns	35997718	hsa-mir-144	Uremia	5p elevation reduced BUN, Scr, beta2-MG, P, and iPTH levels, and increased free Ca concentration in blood in uremic rats.
target gene	35997665	hsa-mir-148a	Colonic Neoplasms	MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia.
exosome	35997581	hsa-mir-451	Acute Lung Injury	In the previous study, we have proved that exosomal miR-451 from human umbilical cord mesenchymal stem cells (hUC-MSCs) attenuated burn-induced acute lung injury (ALI). In conclusion, we indicated that hUC-MSCs-derived exosomal miR-451 alleviated ALI by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway, which provided great scientific significance and clinical application value for the treatment of burn-induced ALI.
lncRNA target	35997481	hsa-mir-223	Myocardial Infarction	In addition, we conducted a series of rescue experiments to affirm that ZNF561-AS1 regulated cell proliferation and apoptosis in MI through miR3p/NLRP3 axis.
other	35997316	hsa-mir-496a	Huntington Disease	Downregulation of TRAX enhanced 83 miRNAs (including miR3p, miR-496a-3p) and subsequently changed the corresponding mRNA networks critical for HD pathogenesis (eg, DARPP-32 and brain-derived neurotrophic factor).
circulation_biomarker_diagnosis_down	35997271	hsa-mir-155	Pulmonary Fibrosis	5p antagomir and si-FOXO3a lentivirus plasmids.
genetics_overexpression_promote	35997119	hsa-mir-612	Retinoblastoma	Results - Overexpression of ZFPM2-AS1 and NT5E and downregulation of miR-3612 expression levels were observed in RB cells and tissues.
genetics_overexpression_promote	35997118	hsa-mir-18b	Esophageal Squamous Cell Carcinoma	lncRNA ZNF667-AS1 overexpression accelerated RASA1 transcription by competitively binding to miR-18b-5p, thus suppressing ESCC cell proliferation and invasion.
genetics_knock down_suppress	35997116	hsa-mir-200b	Incontinentia Pigmenti	ZEB2 knockdown reversed the inhibitory effect of miR-200b-3p downregulation on IPC differentiation from UCMSCs in vitro.
lncRNA target	35997115	hsa-mir-335	Breast Neoplasms	In breast cancer, SDC1 was a target gene of miR
genetics_overexpression_promote	35997114	hsa-mir-10a	Carcinoma, Hepatocellular	In HCC cells, overexpression of PCED1B-AS1 decreases miR-10a expression and increases BCL6 expression.
lncRNA target	35997113	hsa-mir-15a	Liver Neoplasms	In vivo assays were further performed and miR-15a-5p inhibited the growth of liver cancer.
circulation_biomarker_diagnosis_up	35997022	hsa-mir-29	Pulmonary Arterial Hypertension	In the cytoplasm, circSMOC1 acted as a miR
lncRNA target	35996717	hsa-mir-21	Adenocarcinoma of Lung	CONCLUSION: Calycosin can inhibit colony formation, invasion, migration, and EMT process of LUAD cells via regulating the circ_0001946/miR-21/GPD1L/HIF-1alpha signaling axis and could be a promising therapeutic drug for LUAD.
genetics_GWAS	35996522	hsa-mir-499	Polycystic Ovary Syndrome	Conclusion: Single SNPs and haplotype combinations in certain SNPs in miR-126, miR-146a, miR-196a2 and miR-499 are strongly linked to PCOS, and so may be useful predictors of this condition.
genetics_GWAS	35996520	hsa-mir-137	Gastric And Colon Cancer	The aim of this study was to investigate the association of functional variable number tandem repeat (VNTR) polymorphism rs58335419 locating in the upstream of the MIR137 gene with the risk of colon and gastric cancers.
circulation_biomarker_diagnosis_up	35996513	hsa-mir-206	Carotid Stenosis	Conclusion: Serum miR-206 has high diagnostic accuracy for asymptomatic CAS and has predictive value for the incidence of CIEs in patients within 5 years.
transcription factor target	35996510	hsa-mir-640	Glioma	These results suggest that miR-640 mediates the radiosensitivity of glioma cells through SLIT1 and the Wnt/beta-catenin signaling pathway.
other	35996508	hsa-mir-124-1	Endometriosis	1 rs531564, are linked to endometriosis.
other	35996508	hsa-mir-423	Endometriosis	1 rs531564, are linked to endometriosis.
other	35996508	hsa-mir-27a	Endometriosis	1 rs531564, are linked to endometriosis.
circulation_biomarker_diagnosis_ns	35996507	hsa-mir-152	Diabetes Mellitus, Type 2	This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy.
circulation_biomarker_diagnosis_ns	35996507	hsa-mir-93	Diabetic Retinopathy	This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy.
circulation_biomarker_diagnosis_ns	35996507	hsa-mir-93	Diabetes Mellitus, Type 2	This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy.
circulation_biomarker_diagnosis_ns	35996507	hsa-mir-152	Diabetic Retinopathy	This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy.
lncRNA target	35996500	hsa-mir-650	Adenocarcinoma of Lung	CARD8-AS1/miR-650 may serve as novel prognostic biomarkers and potential therapeutic targets for the treatment of lung adenocarcinoma.
lncRNA target	35996496	hsa-mir-1179	Carcinoma, Non-Small-Cell Lung	Inhibited expression of LINC01929 significantly reduced the proliferation, migration, and invasion of NSCLC cells by targeting miR-1179.
circulation_biomarker_prognosis_ns	35996079	hsa-mir-130a	Cerebrovascular Disorders	CONCLUSION: All the findings indicated that high serum miR-130a-3p had diagnostic potential to screen cerebral AS, and predicted the probability of cerebrovascular events after AS.
circulation_biomarker_prognosis_ns	35996079	hsa-mir-130a	Atherosclerosis	CONCLUSION: All the findings indicated that high serum miR-130a-3p had diagnostic potential to screen cerebral AS, and predicted the probability of cerebrovascular events after AS.
circulation_biomarker_diagnosis_up	35995288	hsa-mir-21	Angelman Syndrome	Our findings suggest that occupational noise exposure is positively associated with AS, and plasma miR-92a-3p and miR
circulation_biomarker_diagnosis_up	35995288	hsa-mir-92a	Angelman Syndrome	Our findings suggest that occupational noise exposure is positively associated with AS, and plasma miR-92a-3p and miR
transcription factor target	35995138	hsa-mir-143	Triple Negative Breast Neoplasms	Previously, we demonstrated that adding targeting sequences (TS) of miR-145/143, which are downregulated in cancer compared with normal cells, into CVB3 genome drastically attenuates tissue toxicity, while retaining its oncolytic activity towards lung tumor.
transcription factor target	35995138	hsa-mir-145	Triple Negative Breast Neoplasms	Previously, we demonstrated that adding targeting sequences (TS) of miR-145/143, which are downregulated in cancer compared with normal cells, into CVB3 genome drastically attenuates tissue toxicity, while retaining its oncolytic activity towards lung tumor.
other	35995115	hsa-mir-134	Hearing Loss, Unilateral	3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05).
other	35995115	hsa-mir-425	Hearing Loss, Unilateral	3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05).
other	35995115	hsa-mir-199a	Hearing Loss, Unilateral	3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05).
other	35994808	hsa-mir-205	Breast Neoplasms	High miR-205 expression had a detrimental effect on BC patient outcome.
other	35994229	hsa-mir-1205	Glioma	Circ_0001982 accelerates glioma progression by modulating the miR-1205/E2F1 axis.
circulation_biomarker_diagnosis_down	35994228	hsa-mir-210	Pneumonia	In this study, expression of SNHG16 and microRNA (miR)-210 in pneumonia plasma samples (n = 56) and control samples (n = 60) was detected by RT-qPCR.
genetics_knock down_suppress	35994105	hsa-mir-30	Sepsis	CONCLUSION: Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR5p/ELK1, opening a new window into the pathogenesis AKI.
genetics_knock down_suppress	35994105	hsa-mir-30	Acute Kidney Injury	CONCLUSION: Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR5p/ELK1, opening a new window into the pathogenesis AKI.
lncRNA target	35993956	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	miR-1246 expression levels within clinical LSCC tissues and cell lines (TU212 and AMC-HN-8) were detected through quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay.
lncRNA target	35993945	hsa-mir-455	Carcinoma, Squamous Cell, Cutaneous	GAS5 suppresses cSCC cell proliferation, migration, and invasion by targeting the miR5p/CDKN1B axis.
transcription factor target	35993944	hsa-mir-532	Carcinoma, Non-Small-Cell Lung	In summary, this study demonstrated the tumor-suppressive role of miR
genetics_overexpression_promote	35993943	hsa-mir-488	Pre-Eclampsia	GATA3-AS1 is overexpressed in PE and promotes PE progression by the miR
lncRNA target	35993940	hsa-mir-98	Carcinoma, Non-Small-Cell Lung	In conclusion, Linc00511 was elevated in NSCLC, which might participate NSCLC postoperative distant recurrence and promoted NSCLC cell proliferation, migration and invasion via targeting and regulating miR5p/TGFBR1 axis.
lncRNA target	35993694	hsa-mir-125a	Angelman Syndrome	But the roles of microRNA-125a-3p (miR-125a-3p) in the pathogenesis of AS remain unknown. miR-125a-3p aggravates the dysfunction of HUVECs induced by ox-LDL via BAMBI, which implies that miR-125a-3p is involved in the pathogenesis of AS.
other	35993468	hsa-mir-4316	psoriasis 1	5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis.
other	35993468	hsa-mir-194	psoriasis 1	5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis.
other	35993468	hsa-mir-612	psoriasis 1	5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis.
transcription factor target	35993414	hsa-mir-29a	Inflammation	Ingenuity Pathway Analysis on miR-29a and 34a targets was associated with inflammation through interleukins, TGFbeta and Notch genes, and p53 signaling.
lncRNA target	35993364	hsa-mir-149	Bisphosphonate-Associated Osteonecrosis Of The Jaw	5p on skeletal angiogenesis and bone remolding, suggesting it as a promising preventive and therapeutic target for BRONJ.
other	35993243	hsa-mir-127	Osteoarthritis	CircSCAPER up-regulation in OA cartilages was discovered to be accompanied by decreased miR5p and increased TLR4.
circulation_biomarker_diagnosis_up	35993056	hsa-mir-497	Colorectal Neoplasms	The serum levels of miR-497, CEA, CA24-2, and HBsAg were compared between 60 patients with CRC (observation group) and another 60 patients with colorectal polyps (control group).
other	35993042	hsa-mir-2467	Urinary Bladder Neoplasms	3p) sponge to control the expression of IQ motif containing GTPase activating protein 3 (IQGAP3) and cell division cycle associated 5 (CDCA5), resulting in activation of the rat sarcoma virus (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and PI3K/AKT/mTOR signaling pathways.
other	35993042	hsa-mir-4435-2	Urinary Bladder Neoplasms	CONCLUSION: MIR4435-2HG involves in the progression of BCa, which might provide novel insights for BCa treatment.
other	35992914	hsa-mir-873a	Osteochondrodysplasias	5p.
target gene	35992869	hsa-mir-26a	Osteosarcoma	LncRNA SCAMP1 disrupts the balance between miR-26a-5p and ZEB2 to promote osteosarcoma cell viability and invasion.
lncRNA target	35992812	hsa-mir-625	Endometrial Neoplasms	We also showed that circ_0007534 enhanced endometrial cancer aggressiveness, progression, and paclitaxel resistance by sponging microRNA-625 (miR-625) and subsequently increasing the expression of the miR-625 target gene ZEB2. Targeting the circ_0007534/miR-625/ZEB2 pathway might be an effective strategy for overcoming paclitaxel resistance in endometrial cancer.
genetics_overexpression_promote	35992774	hsa-mir-429	Carcinoma, Endometrioid	LINC01541 interacts with miR-429 to promote the expression of each other, and both inhibit the synthesis of VEGFA in EAC cells after overexpression.
other	35992658	hsa-mir-451a	Inflammation	CONCLUSION: MiR-451a correlates with the Th1/Th2 ratio, and they both relate to inflammation, septic organ injury, and mortality risk in patients with sepsis.
other	35992658	hsa-mir-451a	Sepsis	CONCLUSION: MiR-451a correlates with the Th1/Th2 ratio, and they both relate to inflammation, septic organ injury, and mortality risk in patients with sepsis.
lncRNA target	35992546	hsa-mir-497	Osteoarthritis	Shortly, CircMELK promotes chondrocyte apoptosis and inhibits autophagy in OA by regulating MYD88/NF-kappaB signaling axis through miR
transcription factor target	35992541	hsa-mir-183	Sepsis	5p, which negatively modulated CTSB and Cur-mediated PI3K/AKT pathway via the miR
transcription factor target	35992154	hsa-mir-192	Diabetic Nephropathies	We demonstrate a novel role for miR-192 in directly regulating KL levels, and through that, senescence and oxidative stress, key pathological processes in the development of DN. miR-192 and/or KL levels are altered with severity and duration of diabetes and could serve as early biomarkers for DN.
transcription factor target	35992154	hsa-mir-192	Diabetes Mellitus	We demonstrate a novel role for miR-192 in directly regulating KL levels, and through that, senescence and oxidative stress, key pathological processes in the development of DN. miR-192 and/or KL levels are altered with severity and duration of diabetes and could serve as early biomarkers for DN.
transcription factor target	35992108	hsa-mir-148a	Osteoporosis	MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI. Our findings suggest that miR-148a-3p is a mediator of osteoporosis following spinal cord injury and a potential future therapeutic target.
transcription factor target	35992108	hsa-mir-148a	Spinal Cord Injuries	MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI. Our findings suggest that miR-148a-3p is a mediator of osteoporosis following spinal cord injury and a potential future therapeutic target.
circulation_biomarker_diagnosis_ns	35991513	hsa-mir-7	Carcinoma, Ovarian Epithelial	In addition, in plasma of EOC patients, ciRS-7 negatively correlated with has-miR
transcription factor target	35991122	hsa-mir-181a	Sepsis	Our study indicated miR-181a-5p as a new potential therapeutic target for S-AKI therapy.
transcription factor target	35990993	hsa-mir-205	Nasopharyngeal Carcinoma	5p, thereby it inhibited NPC cell proliferation and metastasis and enhanced radiosensitivity.
genetics_overexpression_suppress	35990825	hsa-mir-216b	Optic Neuritis	In addition, overexpression of FAS exacerbated experimental optic neuritis by promoting the inflammatory response and Th17 cell differentiation, and miR-216b-5p reversed this effect.
lncRNA target	35990372	hsa-mir-655	Nasopharyngeal Neoplasms	In addition, the increase of miR-655 may be a target for treating nasopharyngeal carcinoma.
other	35990342	hsa-mir-663a	Carcinoma, Hepatocellular	Transcriptome analysis of human hepatocellular carcinoma cells (HepG2) under leucine deprivation revealed that hsa-miR-663a and hsa-miR-1469 were altered in a transcription factor 4-dependent manner.
other	35990342	hsa-mir-1469	Carcinoma, Hepatocellular	Transcriptome analysis of human hepatocellular carcinoma cells (HepG2) under leucine deprivation revealed that hsa-miR-663a and hsa-miR-1469 were altered in a transcription factor 4-dependent manner.
other	35989496	hsa-mir-1287	COVID-19	CONCLUSION: The results of this in-vitro and in silico study show that hsa_circ_0004812/hsa-miR5p/IL6R, RIG-I can play an important role in the outcome of COVID-19.
lncRNA target	35989413	hsa-mir-145a	Spinal Cord Injuries	Tug1 contributes NLRP3 inflammasome-dependent pyroptosis through miR-145a-5p/Tlr4 axis post-stroke, providing a promising therapeutic strategy against inflammatory injury.
genetics_GWAS	35989410	hsa-mir-373	Colorectal Neoplasms	CONCLUSION: Considering the role of miR-31 and miR-373 in CRC tumor progression, it seems that the CRC patients bearing KRAS mutations have a poorer prognosis respective to patients without KRAS mutations.
genetics_GWAS	35989410	hsa-mir-1	Colorectal Neoplasms	CONCLUSION: Considering the role of miR-31 and miR-373 in CRC tumor progression, it seems that the CRC patients bearing KRAS mutations have a poorer prognosis respective to patients without KRAS mutations.
genetics_overexpression_promote	35989156	hsa-mir-455	Osteosarcoma	Likewise, overexpressing miR
transcription factor target	35988833	hsa-mir-149	Sepsis	5p may play a crucial role in vitamin-D inhibiting LPS/CLP induce ALI.
transcription factor target	35988833	hsa-mir-149	Acute Lung Injury	5p may play a crucial role in vitamin-D inhibiting LPS/CLP induce ALI.
other	35988655	hsa-mir-22	Osteoporosis, Postmenopausal	The results showed that the expression profiles of lncRNAs could help identify the novel ones involved in the progression of PMOP, and that MIR22HG could serve as a miRNA precursor to regulate FoxO signaling pathway in bone metabolism.
lncRNA target	35988424	hsa-mir-377	Osteoarthritis	Therefore, we concluded that ABPS could inhibit thapsigargin (TG)-induced chondrocyte ERS through the lncRNA NEAT1/miR
other	35988346	hsa-mir-143	Prostatic Neoplasms	miRNA-143 is reported to be associated with the development of prostate cancer.
circulation_biomarker_diagnosis_up	35988281	hsa-mir-214	Heart Failure	3p) on sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and its mechanism on heart failure (HF).
circulation_biomarker_diagnosis_ns	35988268	hsa-mir-21	Heart Neoplasms	In this study, miR-21 has an oncogenic role that can be measured in patients' serum to assess the progression of gastric cancer.
lncRNA target	35988105	hsa-mir-206	Uveomeningoencephalitic Syndrome	Furthermore, we mapped a network of competing endogenous RNAs for hsa-miR-206, which we used to identify putative targets for VKH treatment.
exosome	35988100	hsa-mir-625	Lung Neoplasms	Basing on the results from miRNA sequencing, qRT-PCR and wound healing assay, hsa-miR3p was discovered to be accumulated inside hypoxic exosomes and responsible for the metastasis of lung cancer cell.
lncRNA target	35987939	hsa-mir-29	Neoplasms, Multiple Primary	Dysregulation of programs associated with >80 RNA-binding proteins (RBPs) and microRNAs (miRNAs) drive these changes, including multi-cancer inactivation of RBFOX and miR-29 families.
exosome	35987860	hsa-mir-21	Polycystic Ovary Syndrome	AMSC-EXOs inhibited the expression of B-cell translocation gene 2 by transferring miR5p to the livers of rats with PCOS, thus activating the IRS1/AKT pathway and increasing hepatic metabolism.
other	35987859	hsa-mir-24	Carcinoma, Hepatocellular	We detected that high expression of miR-24, miR-10b and the low expression of miR-143 were independently and significantly associated with HCC in AFP-stable compared with AFP trending (P < .05). CONCLUSIONS: Although more clinical validations are needed for the diagnosis of HCC, our current results indicate that the coexistence of high expression of miR-10b and miR-24 may help clinicians adjust in the diagnosis of HCC in patients who are on the liver transplant list but awaiting biopsy for the diagnosis of HCC.
genetics_overexpression_promote	35987744	hsa-mir-182	Keloid	5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects.
exosome	35987145	hsa-mir-146b	Osteoarthritis	According to miRNA sequencing analysis of these exosomes and subsequent target activity assays, we confirmed DIG controls OA inflammatory microenvironment and promotes chondrogenesis by, at least partly, downregulating the M1-like macrophage-derived exosomal miR-146b-5p/Usp3&Sox5 axis in vitro and in vivo.
circRNA target	35987088	hsa-mir-198	Stomach Neoplasms	Collectively, our work suggests that the Exo-mediated transfer of circ_0038138 potentially facilitates the glycolysis, growth and metastasis of GAC cells via miR-198/EZH2 axis, which offers a potential prognostic marker and a therapeutic target for GAC.
circulation_biomarker_diagnosis_ns	35986985	hsa-mir-21	Breast Neoplasms	This approach further detects circulating ExoPD-L1 and ExomiR-21 in human plasma to differentiate breast cancer patients from healthy individuals with high accuracy, showing great potential of DCNPs for simultaneous profiling exosomal surface and inside biomarkers, and for clinical precision diagnosis.
other	35986741	hsa-mir-518a	Breast Neoplasms	An in-depth understanding of the role of the miR-518a-5p in BC can help clinicians to understand the pathogenic mechanism of breast cancer more accurately.
other	35986538	hsa-mir-130a	Colorectal Neoplasms	In addition, a few miRNAs (miR-27a-3p and miR-130a-3p) and drugs (triclosan, soman, reserpine, and isoproterenol, etc.) were found capable to alter the expression of hub genes and thus need to further be evaluated for their potential role in CRC treatment.
other	35986538	hsa-mir-27a	Colorectal Neoplasms	In addition, a few miRNAs (miR-27a-3p and miR-130a-3p) and drugs (triclosan, soman, reserpine, and isoproterenol, etc.) were found capable to alter the expression of hub genes and thus need to further be evaluated for their potential role in CRC treatment.
lncRNA target	35986526	hsa-mir-137	Esophageal Squamous Cell Carcinoma	CONCLUSION: These findings have uncovered the new function of miR-137 in ESCC via negatively regulating DAAM1, suggesting miR-137 as a potent therapeutic candidate for ESCC treatment.
lncRNA target	35986524	hsa-mir-490	Myocardial Infarction	3p alleviates cardiomyocyte injury via targeting FOXO1 in MI.
genetics_overexpression_promote	35986524	hsa-mir-490	Cardiomyopathy, Hypertrophic	3p overexpression inhibited HCM cell inflammatory responses and injury after hypoxia treatment.
other	35986524	hsa-mir-490	Cardiovascular Diseases	3p) plays a role in the pathogeneses of a variety of cardiovascular diseases.
target gene	35986482	hsa-mir-200a	Glucose Metabolism Disorders	Meanwhile, melatonin effectively inhibited miR-200a-3p and glucose metabolism disorder.
circulation_biomarker_diagnosis_up	35986376	hsa-mir-142	Rotator Cuff Injuries	RESULTS: Circulating exosomal miRNAs sequencing showed that, compared to exosomes from patients without adhesive capsulitis, miR-142 was significantly up-regulated in exosomes from adhesive capsulitis (Exo-S).
other	35986343	hsa-mir-548s	Carcinoma, Hepatocellular	CONCLUSION: LncMMPA plays an important role in regulating HCC malignancy and metabolic reprogramming of miR-548 s/ALDH1A3 pathway.
genetics_overexpression_promote	35986311	hsa-mir-29b	Leukemia, Myeloid, Acute	When miR-29b-3p was overexpressed in AML cells, HuR was down-regulated, accompanied by cell viability decreased, cell cycle arrest, apoptosis increased, invasion and migration weakened.
circulation_biomarker_diagnosis_up	35986010	hsa-mir-155	Glioma	5p in plasma exosomes from patients was associated with glioma diagnosis and grading.
lncRNA target	35985609	hsa-mir-21	Leukoencephalopathies	5p agomir inhibited the mRNA and protein expression of PTEN, increased p-Akt phosphorylation, and decreased the expression and activation of related apoptotic proteins.On the other hand, the administration of miR
target gene	35985238	hsa-mir-548d	Stomach Neoplasms	LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis.
lncRNA target	35985237	hsa-mir-1307	Carcinoma, Hepatocellular	Targeting a vicious feedback loop between HIF-1alpha/miR
genetics_overexpression_promote	35985176	hsa-mir-494	Triple Negative Breast Neoplasms	Finally, in a xenograft model, both miR-494 overexpression and the HIF-1alpha inhibitor PX-478 increased the sensitivity of TNBC to DTX by suppressing the HIF-1alpha/miR-494/Survivin signaling pathway in vivo.
genetics_GWAS	35984881	hsa-mir-501	Schizophrenia	The epigenetic and pathophysiological mechanism that links miR
genetics_knock down_promote	35984862	hsa-mir-2	Parkinson Disease	In support of this, we demonstrated that RNAi knockdown of multiple mir-2 targets enhanced alpha-syn-induced DA neurodegeneration.
exosome	35984761	hsa-mir-25	Substance Abuse, Intravenous	Extracellular vesicles derived from PRP containing miR3p may be a new method for IVD treatment.
genetics_overexpression_promote	35984761	hsa-mir-25	Nerve Degeneration	3p or overexpressing SOX4 or CXCR7 reversed the alleviating role of PRP-EVs in NP cell degeneration.
genetics_overexpression_promote	35984761	hsa-mir-25	Niemann-Pick Diseases	3p or overexpressing SOX4 or CXCR7 reversed the alleviating role of PRP-EVs in NP cell degeneration.
lncRNA target	35984706	hsa-mir-199a	Myocardial Reperfusion Injury	This study was to probe the role of penehyclidine hydrochloride (PHC) mediating the impact of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-kappaB) signalling pathway on myocardial ischaemia-reperfusion injury (MI/RI) in rats through miR-199a-3p. In conclusion, PHC suppresses TLR4/MyD88/NF-kappaB signalling pathway through miR-199a-3p, thereby improving MI/RI in rats.
epigenetics	35984699	hsa-mir-4717	Colorectal Neoplasms	Furthermore, we confirmed that methyltransferase-like 3 (METTL3)-dependent m(6) A methylation could methylate primary (pri)-miR-4717, which further promoted the maturation of pri-miR-4717, and METTL3 positively regulated CRC cell proliferation through miR-4717/MAP2K4 pathways.
lncRNA target	35984595	hsa-mir-148a	Fibrosis, Atrial	Collectively, Sal B can protect the Ang II-activated FBs from fibrosis and oxidative stress via AMPK/FoxO1/miRNA-148a-3p axis.
genetics_knock down_promote	35984539	hsa-mir-633	Arthritis, Rheumatoid	TRAF6 was a direct target of miR-633, and miR-633 overexpression suppressed the aggressive changes of RA-FLSs by down-regulating TRAF6.
target gene	35984538	hsa-mir-640	Glioblastoma	MicroRNA-640 Inhibition Enhances the Chemosensitivity of Human Glioblastoma Cells to Temozolomide by Targeting Bcl2 Modifying Factor.
other	35984199	hsa-mir-509	Osteosarcoma	Our study suggests that miR-509 may serve as a potential biomarker for evaluating OS prognosis and provides clues for tailoring OS immunotherapy strategies.
other	35984198	hsa-mir-21	lung squamous cell carcinoma	3p.
other	35984198	hsa-mir-650	lung squamous cell carcinoma	3p.
other	35984198	hsa-mir-4689	lung squamous cell carcinoma	3p.
other	35984198	hsa-mir-744	lung squamous cell carcinoma	3p.
other	35983819	hsa-let-7c	Prostatic Neoplasms	RESULTS: In our study, hsa-let7c-3p significantly 1,52 (p=0.018) and 1,84 (p=0.0095) fold down- regulated whereas, miR3p was significantly 2,36 (p=0.0006) and 2,24 (p=0.001) fold upregulated in the prostate cancer patients compared to benign prostate hyperplasia in group 1 and 2, respectively.
other	35983819	hsa-mir-143	Prostatic Neoplasms	CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs.
other	35983819	hsa-mir-141	Prostatic Neoplasms	RESULTS: In our study, hsa-let7c-3p significantly 1,52 (p=0.018) and 1,84 (p=0.0095) fold down- regulated whereas, miR3p was significantly 2,36 (p=0.0006) and 2,24 (p=0.001) fold upregulated in the prostate cancer patients compared to benign prostate hyperplasia in group 1 and 2, respectively.
other	35983819	hsa-mir-146a	Prostatic Neoplasms	CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs.
other	35983819	hsa-mir-17	Prostatic Neoplasms	CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs.
other	35983819	hsa-mir-221	Prostatic Neoplasms	CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs.
lncRNA target	35983126	hsa-mir-205	Melanoma	We demonstrated that SNHG16 promotes the metastasis and growth of melanoma through miR5p/PAK2 axis.
genetics_knock down_promote	35983051	hsa-mir-223	Mucocutaneous Lymph Node Syndrome	CONCLUSIONS: The horizontal transfer of platelet-derived miR-223 suppresses the expression of ICAM-1 in HCAECs, which at least in part attenuates leukocyte adhesion, thereby reducing endothelial damage in KD vasculitis.
genetics_knock down_suppress	35982896	hsa-mir-138	Osteoporosis	5p in aging-related bone loss and may provide a powerful therapeutic target for ameliorating senile osteoporosis.
circulation_biomarker_diagnosis_ns	35982888	hsa-mir-370	Glioblastoma	3p/ TGFBR2 and thus may be a potential serum biomarker of GBM.
lncRNA target	35982887	hsa-mir-520h	Urinary Bladder Neoplasms	Conclusions: Our research revealed that nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.
other	35981627	hsa-mir-146a	Neurodegenerative Diseases	CONCLUSIONS: Cel exerts neuroprotective activity against 6-OHDA-caused neurotoxicity by regulating miR-146a/PI3K/Akt/mTOR pathway, which provides a potential application of Cel for treating neurodegenerative diseases.
other	35981627	hsa-mir-146a	Neurotoxicity Syndromes	Moreover, a miR-146a mimic was synthesized and transfected into PC12 cells to further determine the mechanisms of Cel's neuronal protection against 6-OHDA-induced neurotoxicity. CONCLUSIONS: Cel exerts neuroprotective activity against 6-OHDA-caused neurotoxicity by regulating miR-146a/PI3K/Akt/mTOR pathway, which provides a potential application of Cel for treating neurodegenerative diseases.
genetics_overexpression_promote	35981137	hsa-mir-27a	Leukemia	Consequent to AF4 and MLL-AF4 downregulation, MiR-27a overexpression negatively affects transcription of HOXA9 and MEIS1 in different t(4;11) leukemia cell lines.
genetics_knock down_promote	35981103	hsa-mir-124	Glioma	3p or knockdown of CREBRF enhanced apoptosis and autophagy and diminished proliferation of glioma cells.
genetics_overexpression_suppress	35980563	hsa-mir-214	Hypoxia-Ischemia, Brain	3p and overexpressing TXNIP reversed the therapeutic effect of miR
transcription factor target	35980523	hsa-mir-21	salivary gland mucoepidermoid carcinoma	Increased expression of miR-21 (p < 0.001) and decreased expression of miR-145 (p < 0.001) were observed in MECs compared to normal salivary gland tissue. CONCLUSION: Our results support the tumor suppressor role of miR-145 and the oncogenic role of miR-21 in salivary gland MEC.
transcription factor target	35980523	hsa-mir-145	salivary gland mucoepidermoid carcinoma	Increased expression of miR-21 (p < 0.001) and decreased expression of miR-145 (p < 0.001) were observed in MECs compared to normal salivary gland tissue. CONCLUSION: Our results support the tumor suppressor role of miR-145 and the oncogenic role of miR-21 in salivary gland MEC.
exosome	35980503	hsa-mir-135a	Carcinoma, Non-Small-Cell Lung	It was found that cancer cell-derived exosomal LINC00313 promoted M2 macrophage differentiation in NSCLC by up-regulating STAT6 as miR-135a-3p sponge.
genetics_knock down_suppress	35980117	hsa-mir-582	Leukemia, Myeloid, Acute	3p inhibition ameliorated the impacts of circPTK2 knockdown on AML cell processes.
transcription factor target	35980063	hsa-mir-153	Nervous System Diseases	Given the growing interest in miR-153 as a biomarker and therapeutic target for neurological diseases as well as the lack of comprehensive investigation of miR-153 function in these disorders, it is necessary to identify the downstream and upstream targets and also it's potential as a therapeutic biomarker target.
genetics_overexpression_promote	35979756	hsa-mir-20b	Leukemia, Promyelocytic, Acute	Moreover, miR-320a/b upregulation promoted cell cycle arrest in the G1 phase and suppressed the viability of APL cells, and the impacts were reversed by ARNTL overexpression. In conclusion, miR-320a/b suppresses cell viability and leads to cell cycle arrest by suppressing ARNTL in APL.
genetics_overexpression_promote	35979756	hsa-mir-20a	Leukemia, Promyelocytic, Acute	Moreover, miR-320a/b upregulation promoted cell cycle arrest in the G1 phase and suppressed the viability of APL cells, and the impacts were reversed by ARNTL overexpression. In conclusion, miR-320a/b suppresses cell viability and leads to cell cycle arrest by suppressing ARNTL in APL.
other	35979583	hsa-mir-22	High Pressure Neurological Syndrome	3p was extensively expressed in dental pulp cells.
other	35979583	hsa-mir-22	Pulpitis	AIM: To investigate the synergetic regulatory effect of miR-22 on HIF-1alpha and NLRP3, subsequently regulating the production of the NLRP3/CASP1 inflammasome pathway-mediated proinflammatory cytokines IL-1beta and IL-18 in human dental pulp fibroblasts (HDPFs) during the progression of pulpitis. RESULTS: A decrease in miR-22 and an increase in HIF-1alpha and NLRP3 in HDPTs occurred during the transformation of reversible pulpitis into irreversible pulpitis compared with that in the healthy pulp tissues (p < .05).
circRNA target	35979014	hsa-mir-1	Sepsis Induced Liver Injury	CONCLUSION: Taken together, circ-Katnal1 enhanced inflammatory pyroptosis in sepsis-induced liver injury through the miR5p/GSDMD axis.
genetics_overexpression_suppress	35978929	hsa-mir-374a	Acute Lung Injury	In addition, ZEB1 was revealed to be a downstream target of miR-374a-5p, and overexpression of ZEB1 could reverse the anti-apoptotic and anti-inflammatory effects of miR-374a-5p on an LPS-induced sepsis cell model.
genetics_overexpression_promote	35978818	hsa-mir-124	Cholangiocarcinoma	5p was upregulated in serum exosomes from CHOL patients and exosomes from CHOL cells, and overexpression of miR
target gene	35978816	hsa-mir-24-1	Carcinoma, Renal Cell	FBP1 /miR-24-1/enhancer axis activation blocks renal cell carcinoma progression via Warburg effect.
epigenetics	35978806	hsa-mir-27a	Breast Neoplasms	MiR-27a-3p binds to TET1 mediated DNA demethylation of ADCY6 regulates breast cancer progression via epithelial-mesenchymal transition.
other	35978628	hsa-mir-212	Otitis Media	The mRNA and protein expression levels of hsa-miR5p, type 1 cannabinoid receptor (CNR1), alkaline phosphatase (ALP), Runx2, osteocalcin (OCN), and collagen 1 A1 (COL1A1) in the OM and PRP groups were detected by qRT-PCR and Western blot analyses.
lncRNA target	35978508	hsa-let-7	Atherosclerosis	Recently, studies have reported that the RNA binding protein Lin28b directly regulates the let-7 microRNA (miRNA), which participates in the process of atherosclerosis (AS) by regulating inflammation. Taken together, these findings indicate that Sirt6 inhibits vascular endothelial cell pyroptosis by negatively regulating the Lin28b/let-7 pathway in AS.
genetics_overexpression_suppress	35978504	hsa-mir-548d	Osteoarthritis	Furthermore, miR-548d-5p overexpression partially reversed papain-induced damages on OA rat's knee articular cartilage.
circRNA target	35978501	hsa-mir-940	Inflammation	RESULTS: Circ_0128846 and PTPN12 expression were significantly upregulated, whereas miR-940 was downregulated in the cartilage tissues of OA patients and IL-1beta-treated C28/I2 cells compared with controls. CONCLUSION: Circ_0128846 regulated human chondrocyte proliferation, apoptosis and inflammation through the miR-940/PTPN12 pathway in OA.
exosome	35978499	hsa-mir-223	Myocarditis	We probed into the mechanisms of MSC-EV-enclosed miR
exosome	35978499	hsa-mir-223	Syphilis	We probed into the mechanisms of MSC-EV-enclosed miR
other	35978360	hsa-mir-3976	Carcinoma, Hepatocellular	The aim of this study was to explore the relationship between rs6757 and the HCC risk in the South Chinese population, and the functional significance of rs6757 by affecting the efficacy of microRNA-3976 (miR-3976) binding to the CD147 3'-UTR.
genetics_knock down_promote	35978328	hsa-mir-215	Osteoporosis	Functional loss and acquisition experiments depicted that miR
circulation_biomarker_diagnosis_up	35978298	hsa-mir-148b	Diabetes Mellitus, Type 2	METHODS: We evaluated the expression of miR-148b-3p and miR-27a-3p in the plasma of three groups: 20 prediabetic patients, 20 T2D patients, and 20 healthy controls.
lncRNA target	35978049	hsa-mir-622	Colorectal Neoplasms	In conclusion, the present study indicates that SP100-AS1/miR-622/ATG3 axis contributes to radioresistance and autophagic activity in CRC patients, suggesting it has huge prospects as a therapeutic target for improving CRC response to radiation therapy.
transcription factor target	35977804	hsa-mir-34	Endometriosis	3p as a potential therapeutic target in endometriosis.
transcription factor target	35977075	hsa-mir-135a	Sepsis	CONCLUSIONS: Our study suggested that the protective effect of miR-135a inhibitor on LPS-induced THP-1 cells injury was realized by regulation of MYOM1, which might afford a pair of novel molecules for sepsis clinical diagnosis.
transcription factor target	35977046	hsa-mir-520c	Carcinoma, Non-Small-Cell Lung	Considering the critical role of sphingolipids in NSCLC, our study advocates the target CERS6 which can be potentially inhibited using hsa-miR-520c-3p to combat NSCLC for future precision medicine.
genetics_knock down_suppress	35976517	hsa-mir-140	Acute  Kidney Injury	CircZNF644 knockdown protected HK-2 cells from LPS-induced injury by altering miR5p/MLKL pathway, suggesting that circZNF644 may be a hopeful therapeutic target for AKI.
lncRNA target	35976514	hsa-mir-548	Stomach Neoplasms	Inhibition of miR-548 might be a novel therapeutic strategy for gastric cancer.
genetics_overexpression_promote	35976474	hsa-mir-339	Nasopharyngeal Carcinoma	3p overexpression inhibited NPC tumor growth in vivo.
exosome	35976364	hsa-mir-181c	Neuralgia	Here we investigated the therapeutic effect of exosomal miR-181c-5p (ExomiR-181c-5p) on a rat model of neuropathic pain induced by sciatic nerve chronic constriction injury (CCI).
other	35976169	hsa-mir-192	Diabetic Nephropathies	5p are associated with the development of DN and may be potential biomarkers for the early diagnosis of DN.
genetics_overexpression_promote	35975858	hsa-mir-299	Squamous Cell Carcinoma of Head and Neck	Moreover, FOXN3 overexpression partially reversed the promoting effects of miR
genetics_knock down_suppress	35975639	hsa-mir-588	Stomach Neoplasms	CONCLUSIONS: circ-LDLRAD3 knockdown reduced DDP resistance and blocked the malignant development of DDP-resistant GC by modulating the miR-588/SOX5 pathway.
circulation_biomarker_diagnosis_ns	35975539	hsa-mir-326	Polycystic Ovary Syndrome	CONCLUSIONS: The study showed that serum miR-184 and miR-326 are highly expressed in PCOS patients and can be used as molecular biomarkers for PCOS diagnosis.
circulation_biomarker_diagnosis_ns	35975539	hsa-mir-184	Polycystic Ovary Syndrome	CONCLUSIONS: The study showed that serum miR-184 and miR-326 are highly expressed in PCOS patients and can be used as molecular biomarkers for PCOS diagnosis.
circulation_biomarker_prognosis_ns	35975537	hsa-mir-221	Diabetes, Gestational	The high expression of miR-221 and miR-320 in the peripheral plasma of pregnant women may directly or indirectly participate in the occurrence and development of GDM or may become a new target for the diagnosis, treatment, and prognosis of GDM.
circulation_biomarker_prognosis_ns	35975537	hsa-mir-20	Diabetes, Gestational	The high expression of miR-221 and miR-320 in the peripheral plasma of pregnant women may directly or indirectly participate in the occurrence and development of GDM or may become a new target for the diagnosis, treatment, and prognosis of GDM.
lncRNA target	35975534	hsa-mir-155	Thrombocytopenia	The interaction network of core downstream target genes and ITP differentially expressed genes of miR-21 and miR-155 were constructed with the STRING database, and the associated factors were verified by qPCR.
other	35975529	hsa-mir-126	Pulmonary Embolism	CONCLUSIONS: Lower levels of miRNA-145 and higher levels of miRNA-126 associated with worse diagnosis PE in patients with COPD.
other	35975529	hsa-mir-126	Pulmonary Disease, Chronic Obstructive	CONCLUSIONS: Lower levels of miRNA-145 and higher levels of miRNA-126 associated with worse diagnosis PE in patients with COPD.
other	35975488	hsa-mir-641	Ischemic Stroke	In the study, we aimed to study the role and underlying mechanism of miR-641 in ischemic stroke. CONCLUSIONS: MiR-641 may be a novel therapeutic agent for ischemic stroke by modulating the MCL-1/Wnt/beta-catenin axis on neuronal damage in brain tissue in the ischemic region after ischemic stroke.
circulation_biomarker_diagnosis_up	35975247	hsa-mir-222	Polycystic Ovary Syndrome	Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group.
circulation_biomarker_diagnosis_up	35975247	hsa-mir-132	Polycystic Ovary Syndrome	Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group.
circulation_biomarker_diagnosis_up	35975247	hsa-mir-146a	Polycystic Ovary Syndrome	Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group.
transcription factor target	35975203	hsa-mir-1290	Colorectal Neoplasms	We demonstrated that miR-1290 enhanced proliferation, migration, and angiogenesis partially through suppression of THBS1, DKK3, and SCAI in CRC.
exosome	35974445	hsa-mir-518c	Short Stature, Idiopathic, Autosomal	CONCLUSIONS: The authors identified a novel pathogenesis in ISS that exosome-derived hsa_circ_0063476 retards the expression of markers of endochondral ossification and impairs longitudinal bone growth via miR-518c-3p/DDX6 axis, which may provide a unique therapeutic avenue for ISS.
genetics_overexpression_promote	35974419	hsa-mir-148a	Carcinoma, Non-Small-Cell Lung	When miR-148a-3p was overexpressed, this reversed the impact of knocking down circ_0009043 on the apoptotic death and proliferation of NSCLC cells.
genetics_overexpression_promote	35974258	hsa-mir-222	Pancreatic Carcinoma	3p overexpressing M2 MDEs were treated with gemcitabine and co-cultured with PCa cells for in vitro experiments.
transcription factor target	35974199	hsa-mir-155	Breast Neoplasms	Achieving the early diagnosis of breast cancer, through ultrasensitive detection of tumor marker miRNA-155, is a significant challenge.
lncRNA target	35972581	hsa-mir-29c	Carcinoma, Non-Small-Cell Lung	Moreover, RP11-79H23.3 siRNA facilitated the progression of NSCLC partially via regulating the expression of miR-29c and the activation of Wnt/beta-catenin signaling pathway.
transcription factor target	35972577	hsa-mir-210	Lung Neoplasms	3p modulated CELF2 expression, thus affecting cell phenotypes and cell cycle distribution in LUSC through PI3K/AKT pathway.
target gene	35972306	hsa-mir-196a	Thyroid Neoplasms	LncRNA-IQCH-AS1 sensitizes thyroid cancer cells to doxorubicin via modulating the miR-196a-5p/PPP2R1B signalling pathway.
other	35971931	hsa-let-7d	Obesity	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971931	hsa-mir-193b	Insulin Resistance	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971931	hsa-mir-193b	Obesity	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971931	hsa-mir-222	Insulin Resistance	CONCLUSIONS: Lower miR-222 levels are associated with IR, and PTEN and p53 expression; the implication of these genes in adipose tissue homeostasis needs more research.
other	35971931	hsa-mir-222	Werner Syndrome	mRNA expression of PTEN and p53 was lower in OW/OB subjects with and without IR, compared to NW group and its levels positively associated with miR-222.
other	35971931	hsa-mir-222	Obesity	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971931	hsa-mir-378	Insulin Resistance	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). RESULTS: miR-222 was lower in IR subjects, and miR-222 and miR-378 negatively correlated with HOMA-IR.
other	35971931	hsa-let-7d	Insulin Resistance	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971931	hsa-mir-378	Obesity	INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53).
other	35971848	hsa-mir-126	Asthma	5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma.
other	35971848	hsa-mir-16	Asthma	All of them, except miR5p were upregulated in MSA patients compared to MA.
other	35971848	hsa-mir-146a	Asthma	5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma.
other	35971848	hsa-mir-215	Asthma	5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma.
other	35971848	hsa-mir-21	Asthma	5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma.
lncRNA target	35971776	hsa-mir-7002	Fanconi Syndrome	These results demonstrated that HG-exo carries excessive miR5p and inhibits autophagy through targeting Atg9b; this process then induces renal tubular dysfunction and inflammation.
lncRNA target	35971776	hsa-mir-7002	Inflammation	These results demonstrated that HG-exo carries excessive miR5p and inhibits autophagy through targeting Atg9b; this process then induces renal tubular dysfunction and inflammation.
circRNA target	35971749	hsa-mir-885	Squamous Cell Carcinoma of Head and Neck	Collectively, circSERPINA3 promotes proliferation, migration, and invasion of LSCC cells by targeting miR
other	35971429	hsa-mir-190	Insulinoma	Taken together, our findings suggest that the miR-190/Cybb axis plays an important role in glucotoxicity-induced pancreatic beta-cell failure.
other	35971429	hsa-mir-190	Diabetes Mellitus, Type 2	Restoring miR-190 expression levels may be a possible therapeutic strategy to protect beta-cells in T2DM.
other	35971429	hsa-mir-190	Pancreatic Diseases	Taken together, our findings suggest that the miR-190/Cybb axis plays an important role in glucotoxicity-induced pancreatic beta-cell failure.
lncRNA target	35971175	hsa-mir-122	Infertility, Male	5p) showing consistent dysregulation in infertility across a minimum of four studies.
lncRNA target	35971159	hsa-mir-216b	Esophageal Squamous Cell Carcinoma	LIPH-4 played an oncogenic role in ESCC through the miR-216b/IGF2BP2 axis. CONCLUSIONS: This study suggested that LIPH-4 functions as a novel oncogenic lncRNA by acting as a ceRNA for miR-216b to regulate IGF2BP2, indicating LIPH-4 likely constitutes a prognostic biomarker and therapeutic target in ESCC.
genetics_knock down_promote	35970794	hsa-mir-17	Multiple Myeloma	After over expression or knockdown of miR
transcription factor target	35970246	hsa-mir-138	Prostatic Neoplasms	5p targeted and partially neutralized the role of WWC1 in Pca cells.
lncRNA target	35970245	hsa-mir-1229	Stomach Neoplasms	Circ_0005758 acts as a tumor suppressor to impede gastric cancer progression via miR3p/GCNT4 axis, implying that therapeutic targeting of circ_0005758 may better to prevent gastric cancer.
lncRNA target	35970002	hsa-mir-1271	Endometriosis	miR-1271 and its direct target gene, GRB2 (growth factor receptor-bound protein 2), expression have been studied in gynecologic cancers, while their role in endometriosis has not been studied.
genetics_overexpression_suppress	35969184	hsa-mir-499	Behcet Syndrome	5p overexpression contributes to dendritic impairments, deregulated calcium homeostasis, and neurocognitive dysfunction in BD.
transcription factor target	35969018	hsa-mir-320c	Norrie disease	Our study proposed to investigate the miR-320c expression and its function on the pathogenesis of DN in vitro. Therefore, inhibition of miR-320c could alleviate toxicity of HK-2 cells induced by HG via targeting PTEN and restraining the PI3K/AKT pathway, illustrating that miR-320c may act as a new biomarker in the diagnosis of DN.
genetics_overexpression_promote	35969010	hsa-mir-192	Stomach Neoplasms	5p was overexpressed in tumour and was associated with poor prognosis in GC.
genetics_overexpression_promote	35968984	hsa-mir-145	Breast Neoplasms	To conclude, p53-induced activation of miR-145 could be inhibited by CCAT2, while overexpression of CCAT2 could improve the drug resistance of BC cells to 5-Fu.
other	35968900	hsa-mir-139	Instent Restenosis	5p-SP1 axis pairs were found in the miRNA-mRNA network, which could promote ISR development.
other	35968900	hsa-mir-24	Instent Restenosis	5p-SP1 axis pairs were found in the miRNA-mRNA network, which could promote ISR development.
genetics_overexpression_promote	35968506	hsa-mir-99a	Atherosclerosis	In vivo, the specific overexpression of miR-99a-5p significantly reduced atherosclerotic lesions, accompanied by a significant downregulation of autophagy marker CD68 protein expression.
exosome	35968497	hsa-mir-520f	Aortic Aneurysm, Abdominal	Therefore, BMSC exosome-derived SBF2-AS1 promotes AAA formation through the miRNA-520f-3p/SMARCD1 axis.
target gene	35968353	hsa-mir-133a	Colorectal Neoplasms	MIR133A regulates cell proliferation, migration, and apoptosis by targeting SOX9 in human colorectal cancer cells.
target gene	35968334	hsa-mir-1297	Osteosarcoma	miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2.
circulation_biomarker_prognosis_down	35968285	hsa-mir-4297	Glioma	CONCLUSION: Our study uncovers sex-dependent characterization of serum miR-4297 in predicting glioma grade and the relapse risk for female patients, which underscores the clinical benefits of sex-specific analysis in non-coding RNA research.
lncRNA target	35967914	hsa-mir-23b	Keloid	CONCLUSION: These findings suggested that inhibition of miR-23b-3p/A20/RIPK1 axis induced apoptosis, limited proliferation and decreased extracellular matrix of KFs, providing a potential therapeutic target for treatment of keloid.
other	35967345	hsa-mir-144	Colitis	The manipulation of miR-144/451 expression and DCs activation in IBD patients may be a novel therapeutic approach for the treatment of inflammatory diseases.
circulation_biomarker_diagnosis_ns	35967275	hsa-mir-137	Substance Withdrawal Syndrome	Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.
circulation_biomarker_diagnosis_ns	35967275	hsa-mir-137	Cognition Disorders	Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.
genetics_overexpression_promote	35966888	hsa-mir-133a	Glioma	The IGFBP3 overexpression effectively counteracts the glioma cell proliferation-inhibiting impact of miR-133a-5p.
other	35966515	hsa-mir-26b	Primary Aldosteronism 	Unlike patients with NFA, miRNA-132, miRNA-143, miRNA-221, and miRNA-26b were less expressed in surrounding adrenal neoplasia AT compared to subcutaneous AT in patients with APA.
circulation_biomarker_prognosis_ns	35966511	hsa-mir-940	Adenocarcinoma of Lung	5p expression in LUAD and T stage (P=0.005), pathologic stage (P=0.047), race (White vs Asian &amp; Black or African American) (P=0.041), residual tumor (P=0.043), and anatomic neoplasm subdivision2 (P=0.030).
other	35966402	hsa-mir-653	Uterine Cervical Neoplasms	CONCLUSION: miR-3653, increased in CC, is related to HPV infection and may serve as a diagnostic and prognostic biomarker for CC patients.
other	35966325	hsa-mir-200	Ovarian Neoplasms	DISCUSSION: The miR-200 family may be a marker for the diagnosis evaluation of ovarian cancer patients.
other	35966312	hsa-mir-1269a	Esophageal Squamous Cell Carcinoma	hsa-miR-1269a is significantly upregulated in ESCA patients with poor prognostic features.
lncRNA target	35966295	hsa-mir-494	Sepsis-Associated Encephalopathy	The purpose of this study is to determine whether miRNA-494 can regulate the activation and oxidative stress of SAE microglia through SIRT3.
transcription factor target	35966249	hsa-mir-579	Adenocarcinoma of Lung	CONCLUSION: Our study reveals that miR-579 acts as a tumor suppressor in LUAD and miR-579 can target and regulate the expression of CRABP2 to mediate cell proliferation and invasion.
circulation_biomarker_diagnosis_up	35966195	hsa-mir-154	Dementia, Vascular	RESULTS: Exosomes isolated from serum of patients with VaD (n = 7) and age-matched control subjects (n = 7), and miRNA sequencing and bioinformatics analysis found that circulating exosome miRNA
transcription factor target	35965805	hsa-mir-194	Cardiomegaly	CONCLUSIONS: In conclusion, increasing the expression of miR-194 can alleviate CH by targeting can and inhibiting the CnA/NFATc2 pathway.
other	35965798	hsa-mir-122	Polycystic Ovary Syndrome	Among the patients with PCOS, miR5p was found to have more significant differences in the PCOS with insulin resistance group.
lncRNA target	35965793	hsa-mir-96	Carcinoma, Hepatocellular	Finally, through multi-data crossover analysis and data analysis of HCC samples further confirmed the existence of the hsa_circ_0039466/miR
other	35965679	hsa-mir-1245	Squamous Cell Carcinoma of Head and Neck	Intriguingly, we identified that miR-1245 simultaneously interacts with KRT80 and HNSCAT1, which bridges the regulatory function between KRT80 and HNSCAT1.
genetics_knock down_promote	35965521	hsa-mir-28	Cholangiocarcinoma	knockdown in these functions (all P &lt;0.05).
lncRNA target	35965517	hsa-mir-137	Glioblastoma	Mechanistically, we identified that XIAP is a bona fide target of miR-137, which is essential for miR
lncRNA target	35965327	hsa-mir-223	Ovarian Neoplasms	CONCLUSION: Circ-BNC2 suppresses the progression of OC via regulating miR
transcription factor target	35965273	hsa-mir-17	Polycystic Kidney Diseases	Remarkably, Pkd2 is also inhibited via its 3'-UTR miR-17 motif, and Pkd2(17)-induced Polycystin-2 derepression retards cyst growth in Pkd1-mutant models.
circRNA target	35964907	hsa-mir-384	Carcinoma, Hepatocellular	CONCLUSION: In this study, circ_0008285 could promote the malignant biological behaviors of HCC cells through miR-384/RRM2 axis and has the potential to become a therapeutic target for HCC, providing a new idea for targeted therapy of HCC.
transcription factor target	35964807	hsa-mir-378	Liver Failure, Acute	CONCLUSION: Together, the present results indicate that miR-378 is a previously unrecognised post-ALF hepatocyte apoptosis regulator and may be a potential therapeutic target in the context of ALF.
tissue_expression_ns	35964709	hsa-mir-3074	Parasitic Diseases	During ex vivo infection of canine and ovine placental explants, we evaluated the expression of 3 miRNAs (miR-30e-3p, miR
tissue_expression_ns	35964709	hsa-mir-127	Parasitic Diseases	During ex vivo infection of canine and ovine placental explants, we evaluated the expression of 3 miRNAs (miR-30e-3p, miR
lncRNA target	35964231	hsa-mir-139	Pre-Eclampsia	CONCLUSION: In summary, we confirmed that circ_0077109 inhibited trophoblast cell function through the regulation of miR5p/HOXD10 axis, which might be a potential target for PE treatment.
genetics_knock down_promote	35963709	hsa-mir-181c	Carcinoma, Non-Small-Cell Lung	Restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 restrained NSCLC cell progression and inactivated the NF-kappaB pathway.
genetics_overexpression_promote	35963185	hsa-mir-210	Carcinoma, Endometrioid	The level of RUNX1T1 in EC was downregulated after overexpressing miR
lncRNA target	35963157	hsa-mir-217	Inflammation	CONCLUSIONS: Our findings for the first time highlighted that Sal alleviated pancreatic injury and inhibited inflammation by regulating miR
lncRNA target	35963157	hsa-mir-217	Pancreatitis	CONCLUSIONS: Our findings for the first time highlighted that Sal alleviated pancreatic injury and inhibited inflammation by regulating miR
circulation_biomarker_diagnosis_up	35962993	hsa-mir-557	Hepatitis, Autoimmune	In addition, serum EV-miR-557 levels >7.69 copies/mul were associated with a significantly higher risk of relapse in patients with AIH (7-year incidence rate: 11.1 vs. 35.4%, log-rank test, p < 0.05).
genetics_knock down_promote	35962723	hsa-mir-219a	Osteoarthritis, Knee	CONCLUSION: miR-219a-5p suppressed the pyroptosis in KOA by inactivating the NLRP3 signaling via targeting FBXO3, which might be a promising target for ameliorating KOA in the clinic.
other	35962561	hsa-mir-19b	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-let-7c	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-29c	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-29c	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-25	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-140	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-140	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-22	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-25	Lewy Body Disease	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-22	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-let-7c	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
other	35962561	hsa-mir-19b	REM Sleep Behavior Disorder	5p, miR-4505, and miR-451a) (false discovery rate P < 0.05).
lncRNA target	35962465	hsa-mir-218	Osteoarthritis	5p/NUMB axis.
circulation_biomarker_diagnosis_ns	35962012	hsa-mir-492	Carcinoma, Non-Small-Cell Lung	qRT-PCR was used to measure expression levels of hsa_circ_0006423 and miR-492 in the plasma and tissue samples, and 3 NSCLC cell lines, respectively.
other	35961957	hsa-mir-596	Carcinoma, Non-Small-Cell Lung	Furthermore, these finding elucidated that miR3p exerts a critical role in brain metastasis of NSCLC by modulating the YAP1-IL8 network, and this miRNA axis may provide a potential therapeutic strategy for brain metastasis.
lncRNA target	35961529	hsa-mir-15b	Diabetic Neuropathies	CONCLUSION: These results suggested that AGEs induced Abeta(1-42) deposition andcognitive decline through H19/miR-15b/ BACE1 axis in DE.
lncRNA target	35961529	hsa-mir-15b	Cognition Disorders	CONCLUSION: These results suggested that AGEs induced Abeta(1-42) deposition andcognitive decline through H19/miR-15b/ BACE1 axis in DE.
other	35961472	hsa-mir-223	Retinopathy of Prematurity	mediated microglial polarization to the M2 phenotype.
other	35961236	hsa-mir-4668	Breast Neoplasms	Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer.
other	35961236	hsa-mir-20b	Breast Neoplasms	Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer.
other	35961236	hsa-let-7c	Breast Neoplasms	Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer.
exosome	35960898	hsa-mir-92a	Colorectal Neoplasms	Herein, a ratiometric fluorescent biosensor based on self-assembled fluorescent gold nanoparticles (Au NPs) and duplex-specific nuclease (DSN)-assisted signal amplification was fabricated for sensitive detection of colorectal cancer (CRC)-associated exosomal miR-92a-3p. This biosensor exhibits excellent specificity and can distinguish CRC patients from healthy individuals by detecting miR-92a-3p extracted from clinical exosome samples, showing the potential in CRC diagnosis.
transcription factor target	35960478	hsa-mir-22	Acute Kidney Injury	However, the mechanism of miR-22 on sepsis-induced AKI is not clearly understood. CONCLUSION: miR-22 can inhibit the inflammatory response, target the HMGB1, and inhibit the HMGB1/TLR4/NF-kB pathway, to attenuate the sepsis-induced AKI, which indicates that miR-22 may serve as a potential treatment target in sepsis-induced AKI.
other	35960478	hsa-mir-122	Sepsis	RESULTS: In AKI rats, kidney injury was observed, accompanied by the down-regulated miR-122 expression and up-regulated HMBG1 expression.
transcription factor target	35960478	hsa-mir-22	Sepsis	However, the mechanism of miR-22 on sepsis-induced AKI is not clearly understood. CONCLUSION: miR-22 can inhibit the inflammatory response, target the HMGB1, and inhibit the HMGB1/TLR4/NF-kB pathway, to attenuate the sepsis-induced AKI, which indicates that miR-22 may serve as a potential treatment target in sepsis-induced AKI.
other	35960478	hsa-mir-122	Acute Kidney Injury	RESULTS: In AKI rats, kidney injury was observed, accompanied by the down-regulated miR-122 expression and up-regulated HMBG1 expression.
circRNA target	35960460	hsa-mir-383	Alzheimer Disease	These findings indicated that circ_0003611 improved Abeta-triggered neuronal injury in AD through targeting the miR5p/KIF1B axis, which might deliver innovative therapy targeting for AD.
circRNA target	35960109	hsa-mir-15b	Intervertebral Disc Degeneration	Hsa_circ_0040039 may serve as a sponge of hsa-miR5p and hsa-miR-15b-5p, to regulate the expression of downstream genes (such as BRTC, SIAH1, and UBE2V1); thus, it may be involved in IDD-associated pathological processes via the Wnt/beta-catenin signaling pathway.
circRNA target	35960109	hsa-mir-424	Intervertebral Disc Degeneration	Hsa_circ_0040039 may serve as a sponge of hsa-miR5p and hsa-miR-15b-5p, to regulate the expression of downstream genes (such as BRTC, SIAH1, and UBE2V1); thus, it may be involved in IDD-associated pathological processes via the Wnt/beta-catenin signaling pathway.
other	35960057	hsa-mir-140	Rotator Cuff Injuries	Furthermore, in situ hybridization was performed to evaluate the presence of miR-140s in patients with massive tears and recurrent shoulder dislocation.
other	35960057	hsa-mir-140	Rotator Cuff	Furthermore, in situ hybridization was performed to evaluate the presence of miR-140s in patients with massive tears and recurrent shoulder dislocation.
lncRNA target	35959879	hsa-mir-505	Primary Graft Dysfunction	5p alleviates acute rejection of liver transplantation by inducing M2 polarization of macrophages via the Myd88/TRAF6 axis, which suggests a potential strategy based on miRNAs in the follow-up treatment of liver transplantation.
transcription factor target	35959614	hsa-mir-34a	Irritable Bowel Syndrome	In colonic mucosal tissues from IBS patients, we detected upregulated miR-34a-5p and suppressed glucose metabolism enzymes expressions. CONCLUSION: Summarily, our study reports the roles and mechanisms of ATL-I in the oxidative stress-induced colonic mucosal epithelial cell dysfunction during IBS through regulating the miR-34a-5p-LDHA-glucose metabolism axis.
target gene	35959437	hsa-mir-8485	Ovarian Neoplasms	Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis.
circulation_biomarker_diagnosis_up	35959150	hsa-mir-186	Diabetic Retinopathy	5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells.
circulation_biomarker_diagnosis_up	35959150	hsa-mir-186	Ischemic Stroke	5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells.
other	35959113	hsa-mir-508	Prostatic Neoplasms	3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage.
other	35959113	hsa-mir-10a	Prostatic Neoplasms	3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage.
other	35959113	hsa-mir-20a	Prostatic Neoplasms	3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage.
lncRNA target	35958914	hsa-mir-133a	Cardiovascular Diseases	Thus, lncRNA-HCG18 inhibited cell viability of cardiac fibroblasts via the hsa-miR-133a/EGFR axis, which was regarded as a regulator of cell proliferation of cardiac fibroblasts in cardiovascular diseases.
genetics_overexpression_promote	35958896	hsa-mir-148a	Carcinoma, Renal Cell	In the cell reverse experiment, overexpression of WNT10a was confirmed to offset the miR-148a mimics effect on metastasis and proliferation of RCC cells.
lncRNA target	35958620	hsa-mir-365	Asthma	stimuated inflammatory response by targeting ARRB2, which would shed new light to the understanding and therapeutics thereof of asthmatic inflammation.
lncRNA target	35958507	hsa-mir-136	Stomach Neoplasms	Mechanistically, circ_0001013 bound to miR-136, which negatively targeted TWSG1 in the GC cells.
other	35958506	hsa-mir-34a	Prostatic Neoplasms	HSA-miR-34a-5p regulates the SIRT1/TP53 axis in prostate cancer.
lncRNA target	35958482	hsa-mir-762	Stomach Neoplasms	It was also found that the effects of miR-762 on GC cells could be reversed by LZTS1, and miR-762 could upregulate the activation of the PI3K/AKT pathway but inhibit the Hippo pathway by targeting LZTS1.
lncRNA target	35958481	hsa-mir-34a	Adenocarcinoma of Lung	Whether MNX1-AS1 was involved in LAC by targeting miR-34a/SIRT1 axis was verified. These results showed that MNX1-AS1 contributes to LAC progression by targeting the miR-34a/SIRT1 axis.
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-1	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-124	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-182	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-23b	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-196a	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	35958461	hsa-mir-34a	Urinary Bladder Neoplasms	RESULTS: Six serum miRNAs (miR
lncRNA target	35958442	hsa-mir-222	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: MiR-222 was significantly upregulated in OSCC tissues and cells and regulated tumor progression by targeting CDKN1B.
circulation_biomarker_diagnosis_ns	35958438	hsa-mir-197	Venous Thrombosis	MATERIALS AND METHODS: Venous blood samples were collected from DVT patients and healthy controls, and peripheral blood mononuclear cells (PBMCs) were isolated to examine the expression patterns of miR
genetics_GWAS	35958297	hsa-mir-21	Multiple Sclerosis	This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions.
genetics_GWAS	35958297	hsa-mir-146a	Multiple Sclerosis	This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions.
other	35958213	hsa-mir-159a	Plant Poisoning	Furthermore, continuously higher expression of the miR159a.2 duplex in transgenic lines with the curly leaf phenotype indicates that miR159a.2 is functional in Arabidopsis and suggests that it is possible for a miRNA precursor to encode several regulatory small RNAs in plants.
other	35958213	hsa-mir-159	Plant Poisoning	Furthermore, continuously higher expression of the miR159a.2 duplex in transgenic lines with the curly leaf phenotype indicates that miR159a.2 is functional in Arabidopsis and suggests that it is possible for a miRNA precursor to encode several regulatory small RNAs in plants.
genetics_overexpression_promote	35958013	hsa-mir-27a	Hypoxia-Ischemia, Brain	Interestingly, the overexpression of miR-27a reduced the infarcted volume and edema induced by HIE.
genetics_overexpression_promote	35958013	hsa-mir-27a	Hypoxia-Ischemia, Brain, Newborn	Interestingly, the overexpression of miR-27a reduced the infarcted volume and edema induced by HIE.
other	35957917	hsa-mir-520a	Pancreatic Neoplasms	MiR-520a-5p/PPP5C regulation pattern is identified as the key to gemcitabine resistance in pancreatic cancer.
lncRNA target	35957833	hsa-mir-370	Stomach Neoplasms	Overall, our present study revealed that the LINC00659/miR-370/AQP3 axis contributes to GC progression, which may provide clues for the exploration of cancer biomarkers and therapeutic targets for GC.
lncRNA target	35957809	hsa-mir-26a	Non-alcoholic Fatty Liver Disease	CONCLUSION: Downregulation of GAS5 can activate the cAMP/CREB pathway through miR-26a-5p/PDE4B axis to mitigate hepatic lipid accumulation.
other	35957803	hsa-mir-4731	Urinary Bladder Neoplasms	Furthermore, an investigation of the downstream and upstream factors of CCDC183-AS1 identified a novel MITF/CCDC183-AS1/miR5p/TCF7L2 axis in BC progression, which might furnish novel insights for developing effective diagnostic and therapeutic strategies for BC.
epigenetics	35957725	hsa-mir-7212	Acute Kidney Injury	The mmu-miR5p-Hmox1 axis in ferroptosis and m6A RNA methylation regulators may have potential clinical significance for the future treatment of SA-AKI.
epigenetics	35957725	hsa-mir-7212	Sepsis	The mmu-miR5p-Hmox1 axis in ferroptosis and m6A RNA methylation regulators may have potential clinical significance for the future treatment of SA-AKI.
other	35957689	hsa-mir-21	Prostatic Neoplasms	A nomogram was constructed that contained four variables (ITGB8, hsa-miR-21, hsa-miR-30b and prostate-specific antigen (PSA) value) for predicting the risk of prostate cancer. The interaction network showed that hsa-miR-21, hsa-miR-30b, and ITGB8 may be utilized as new biomarkers for prostate cancer.
transcription factor target	35957539	hsa-mir-22	Liver Injury	5p as a therapeutic target for liver injury.Abbreviations: ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GSH: Glutathione, gamma-glutamyl cysteinel glycine; CCl(4): Carbon tetrachloride; HE: Haematoxylin and eosin; KEGG: Kyoto Encyclopedia of Genes and Genomes.
circulation_biomarker_diagnosis_up	35956043	hsa-mir-205	Esophageal Squamous Cell Carcinoma	Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR
circulation_biomarker_diagnosis_up	35956043	hsa-mir-375	Esophageal Squamous Cell Carcinoma	Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR
circulation_biomarker_diagnosis_up	35956043	hsa-mir-429	Esophageal Squamous Cell Carcinoma	Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR
other	35955622	hsa-mir-133a	Aphasia, Primary Progressive	In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 /- 0.89 mean /- SD vs.
other	35955622	hsa-mir-106b	Aphasia, Primary Progressive	In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 /- 0.89 mean /- SD vs.
lncRNA target	35955582	hsa-mir-143	Carcinoma, Renal Cell	(4) Conclusions: ERK5 is regulated by miR-143, and ERK5 inhibition is a promising target for ccRCC treatment.
lncRNA target	35955552	hsa-let-7g	Carcinoma, Hepatocellular	In conclusion, our studies demonstrate positive feedback regulation for chronic TLR4 activation in the modulation of TLR4 expression level through the LIN28A/let-7g pathway in HCC and suggest a connection between chronic inflammation and TLR4 expression level in HCC for promoting tumorigenesis.
lncRNA target	35955552	hsa-let-7	Carcinoma, Hepatocellular	In conclusion, our studies demonstrate positive feedback regulation for chronic TLR4 activation in the modulation of TLR4 expression level through the LIN28A/let-7g pathway in HCC and suggest a connection between chronic inflammation and TLR4 expression level in HCC for promoting tumorigenesis.
circulation_biomarker_diagnosis_ns	35955533	hsa-mir-625	Glioblastoma	5p was only identified in MVs isolated from GB patients before surgery and was not detected in plasma.
other	35955467	hsa-mir-34a	Osteoarthritis	RA and OA SF up-regulated miR-34a, -146a, -155, -181a, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, MMP-1, MMP-13, and ADAMTs-5 gene expression, while it down-regulated Col2a1.
other	35955467	hsa-mir-34a	Arthritis, Rheumatoid	RA and OA SF up-regulated miR-34a, -146a, -155, -181a, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, MMP-1, MMP-13, and ADAMTs-5 gene expression, while it down-regulated Col2a1.
other	35955412	hsa-mir-21	Genital Diseases, Female	Overall, this research enhances our understanding of miR-21 function in granulosa cells and the mechanisms of BPA-induced reproductive impairment.
lncRNA target	35954468	hsa-mir-29c	Breast Neoplasms	Elevated miR-29c-5p Expression in Nipple Aspirate Fluid Is Associated with High mammographic density (MD) is associated with an increased risk of breast cancer, however the underlying mechanisms are largely unknown. Further validation and exploration of targets and downstream pathways of has-miR-29c-5p will provide better insight into the processes involved in the development of high MD and in the associated increased risk of breast cancer.
lncRNA target	35954468	hsa-mir-29c	Muscular Dystrophies	Further validation and exploration of targets and downstream pathways of has-miR-29c-5p will provide better insight into the processes involved in the development of high MD and in the associated increased risk of breast cancer.
circulation_biomarker_diagnosis_ns	35954369	hsa-mir-1246	Melanoma	Evaluation of miR-1246 and miR3p baseline plasma levels might help clinicians to identify melanoma patients most likely to be unresponsive to targeted therapy or at higher risk for short-term PFS and mortality, thus improving their management.
circulation_biomarker_diagnosis_ns	35954369	hsa-mir-485	Melanoma	Evaluation of miR-1246 and miR3p baseline plasma levels might help clinicians to identify melanoma patients most likely to be unresponsive to targeted therapy or at higher risk for short-term PFS and mortality, thus improving their management.
genetics_overexpression_promote	35954265	hsa-mir-187	Colorectal Neoplasms	Overexpression of miR
transcription factor target	35954205	hsa-mir-192	Opitz GBBB Syndrome, X-Linked	Among the DEmiRNAs, mi-192 was most induced by H(2)O(2)-mediated OS, and the downregulation of miR-192 alleviated PGC oxidative injury.
lncRNA target	35953862	hsa-mir-520c	Osteosarcoma	CONCLUSIONS: Nectin-4 as an oncogene can promote OS progression and metastasis by activating PI3K/AKT/NF-kappaB signaling via down-regulation of miR-520c-3p, which could represent a novel avenue for identifying a potential therapeutic target for improving patient outcomes.
circulation_biomarker_diagnosis_ns	35953459	hsa-mir-15	Myocardial Infarction, Acute	We then used a rat AMI model to analyze myocardial infarction area by triphenyl tetrazolium chloride staining and assess serum cardiac troponin T level by ELISA and found that miR-15b-5p silencing reduced AMI injury in rats.
circulation_biomarker_diagnosis_ns	35953459	hsa-mir-15b	Myocardial Infarction, Acute	We then used a rat AMI model to analyze myocardial infarction area by triphenyl tetrazolium chloride staining and assess serum cardiac troponin T level by ELISA and found that miR-15b-5p silencing reduced AMI injury in rats.
genetics_overexpression_promote	35953439	hsa-mir-375	Squamous Cell Carcinoma of Head and Neck	Overexpression of CST1 could reverse the anti-cancer effect of miR-375 overexpression in LSCC cells.
other	35953026	hsa-mir-126	Rhinitis, Allergic	CONCLUSION: We propose that miR-126 may be involved in the pathogenesis of AR by positively regulating the expression of Treg cytokines and negatively regulating the expression of the Th1 and Th2 cytokines.
other	35953004	hsa-mir-3714	Encephalitis, Japanese	Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection.
other	35953004	hsa-mir-513a	Encephalitis, Japanese	Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection.
other	35953004	hsa-mir-193b	Encephalitis, Japanese	Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection.
genetics_knock down_promote	35952845	hsa-mir-140	Cerebral Hemorrhage	CONCLUSION: circAFF1 knockdown can suppress neuronal ferroptosis in vivo to attenuate ICH injury, which was associated with its targeting with miR
genetics_knock down_promote	35952595	hsa-mir-96	Wounds and Injuries	Gain- and loss-of-function studies were performed to examine the functions of the XIST/miR
other	35952470	hsa-mir-4261	Infertility	CONCLUSIONS: PPOS protocol could up-regulate the expression of miR5p and down-regulate the expression of miR-4261 in granulosa cells of follicular fluid in infertile patients which involves a lot of cellular and molecular mechanisms requiring follow-up studies.
other	35952470	hsa-mir-6869	Infertility	CONCLUSIONS: PPOS protocol could up-regulate the expression of miR5p and down-regulate the expression of miR-4261 in granulosa cells of follicular fluid in infertile patients which involves a lot of cellular and molecular mechanisms requiring follow-up studies.
transcription factor target	35952464	hsa-mir-7	Pituitary Diseases	CONCLUSIONS: Cav-1/miR5p/SQSTM1 signaling pathway was the mechanism underlying low SS inhibiting endothelial mitophagy that involves mitochondrial homeostasis impairment and endothelial dysfunction.
lncRNA target	35951458	hsa-mir-561	Multiple Myeloma	5p/DLC1 axis inhibited the development of multiple myeloma by Long non-coding RNA NBR2 exerts a tumor-suppressive effect in a variety of cancers, but its role in multiple myeloma (MM) is unclear.
genetics_knock down_promote	35951366	hsa-mir-200b	Breast Neoplasms	Suppression of Dicer inhibited miR-200b expression, whereas miR-200b suppression recovered Dicer knockdown-induced migration, invasion, and cancer stem cells (CSCs) properties of the breast cancer cells.
other	35951089	hsa-mir-1296	Glioma	Subsequently, a combination of a series of bioinformatics analyses, including correlation and survival analyses, identified miR5p as the most potent upstream miRNA of TMED3 in gliomas.Additionally, we analyzed the relationship between TMED3 level and tumor immune cell infiltration and immune checkpoint expression.
genetics_overexpression_promote	35951074	hsa-mir-187	Cataract	RESULTS: The expression of miR-187 increased significantly in patients with cataracts, and the overexpression of miR-187 promoted the oxidative stress response in HLECs.
lncRNA target	35950642	hsa-mir-29b	Skin Aging	CONCLUSION: Our study presented a novel role for BMSCs-exo-miR-29b-3p in improving skin photoaging function, and these findings may provide new insights into the targeted treatment of skin photoaging.
other	35950475	hsa-mir-21	Postoperative Cognitive Complications	The expression of miR-21, miR-132, and miR-200b in PSCI patients was higher than in PSCN patients. CONCLUSIONS: The miR-21 alone or combination of miR-21 and FA values are valuable diagnostic biomarkers in discriminating PSCI from PSCN.
transcription factor target	35950473	hsa-mir-129-1	Ischemic Stroke	CONCLUSIONS: miR1-3p may be a relevant biomarker for the diagnosis of stroke caused by large artery atherosclerosis and could represent a novel therapeutic target for stroke treatment.
other	35950473	hsa-mir-5196	Ischemic Stroke	3p, was significantly different between the AIS and AS/HC groups.
other	35950473	hsa-mir-4312	Ischemic Stroke	3p, was significantly different between the AIS and AS/HC groups.
genetics_overexpression_promote	35950472	hsa-mir-211	Glioma	Moreover, overexpression of RHBDD1 counteracted suppressive effects of miR
exosome	35950471	hsa-mir-152	Subarachnoid Hemorrhage	CONCLUSIONS: Our study confirmed that the CSF-derived exosome miR
genetics_knock down_promote	35950211	hsa-mir-20	Non-Ischemic Diabetic Heart Disease	Our study provides evidence that miR-320 is a late-responding miRNA that aggravates apoptosis and cardiac dysfunction in the diabetic heart, and that therapeutic knockdown of miR-320 is beneficial in partially restoring the deteriorated cardiac function.
other	35949612	hsa-mir-4668	Pancreatic Carcinoma	Thus, the present analysis identified 11 miRNAs associated with pancreatic cancer and further identified miR5p as a potential biomarker for pancreatic cancer diagnosis.
circulation_biomarker_diagnosis_ns	35949317	hsa-mir-499a	Pneumonia	Combination of azithromycin and methylprednisolone alleviates Mycoplasma pneumoniae induced pneumonia by regulating miR-499a-5p/STAT3 axis.
other	35949047	hsa-mir-155	Burns	3p and their related signaling pathways.
other	35949047	hsa-mir-506	Burns	3p and their related signaling pathways.
genetics_knock down_promote	35949038	hsa-mir-873	Colorectal Neoplasms	5p could be sponged by hsa_circ_0045932, and its inhibitor also reversed the inhibitory effect of hsa_circ_0045932 knockdown on CRC cell progression.
lncRNA target	35948893	hsa-mir-26a	Uterine Cervical Neoplasms	CONCLUSIONS: MiR-26a-5p alleviated progression of CC by suppressing proliferation, migration and invasion, promoting apoptosis through downregulating HSDL2.
other	35948417	hsa-mir-181a	Respiratory Distress Syndrome	CONCLUSION: miR-181a-PTEN-pSTAT5-SOCS1 axis is a novel pathway responsible for immunomodulatory effect of MSC EVs in ARDS.
other	35947965	hsa-mir-141	Adenomyosis	CONCLUSION: Circ_0061140 contributed to adenomyosis progression by binding to miR3p to induce LIN28B expression in vitro.
other	35947816	hsa-mir-192	Acquired Immunodeficiency Syndrome	CONCLUSION: Decreased expression levels of miRNA-192 in patients with ocular manifestations and IRU, could facilitate identification of the status of the disease in HIV patients.
other	35947816	hsa-mir-543	Acquired Immunodeficiency Syndrome	RESULTS: Hsa-miR5p and hsa-miR-543 levels were measured by qPCR using RNA isolated from PBMCs of HIVinfected patients.
transcription factor target	35947460	hsa-mir-514	Stomach Neoplasms	Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), functioned as a tumor suppress factor in GC, was found as the downstream target of miR3p, and their expressions were negatively correlated in GC tumor tissues.
lncRNA target	35947460	hsa-mir-514b	Stomach Neoplasms	Our study reveals a novel lncRNA-p21/miR-514b-3p/ARHGEF9 pathway that can be targeted for GC therapy.
genetics_overexpression_promote	35947339	hsa-mir-100	Osteoporosis	TMEM135 was downregulated in osteoporosis and upregulated in differentiated osteoblasts, as well as downregulated upon the overexpression of miR
lncRNA target	35947042	hsa-mir-199a	Carcinoma, Squamous Cell, Skin	CONCLUSIONS: Sulforaphane appears to inhibit sCC progression by impacting its growth and invasion ability, and regulates miR-199a-5p/Sirt1 and CD44ICD signaling pathways, and may be utilized to develop a curative approach for sSCC.
other	35946915	hsa-mir-7106	Dementia	5p).
lncRNA target	35946880	hsa-mir-222	Inflammatory Bowel Diseases	3p targets SOCS1 to aggravate the inflammatory response by suppressing VDR and activating STAT3 signaling in ulcerative colitis.
other	35946568	hsa-mir-1224	Carcinoma, Non-Small-Cell Lung	3p/HMGA2 axis.
circRNA target	35946546	hsa-mir-106b	Uterine Cervical Neoplasms	CircVPRBP and TRIM3 were decreased, and miR-106b-5p was increased in cervical cancer tissues and cell lines. CircVPRBP could inhibit the malignant biological behavior of cervical cancer cells by miR-106b-5p/TRIM3 axis, providing a promising therapeutic target for cervical cancer treatment.
target gene	35946541	hsa-mir-486	Adenocarcinoma of Lung	Circ_0001058 represses the progression of lung adenocarcinoma through governing of the miR-486-5p/TEK signaling axis.
lncRNA target	35946537	hsa-mir-4284	Ovarian Neoplasms	MiR-4284 targeted DMC1 which was downregulated in paclitaxel-resistant cells and reversed the inhibitory influence of miR-4284 silencing on the malignant characters of paclitaxel-resistant OC cells.
other	35946523	hsa-mir-651	Carcinoma, Hepatocellular	5p/TM4SF4 axis-mediated oncogenicity in HCC might shed new light on HCC diagnosis and therapy.
genetics_knock down_promote	35946509	hsa-mir-514a	Wilms Tumor	Changes in the proliferation, migration and apoptosis of WT cells after OSTM1-AS1, miR-514a-3p or MELK knockdown were assessed using the cell counting kit-8, Transwell and caspase-3 activity assays, respectively.
lncRNA target	35946473	hsa-mir-29a	Diabetes Mellitus	We showed microRNA-29a (miR-29a) modulates ADAM12 expression in the setting of diabetes and ischemia. Hence, elevated levels of miR-29a, as seen in diabetes and aging, likely contribute to vascular pathology, and modulation of miR-29a could be a therapeutic target.
other	35946384	hsa-mir-182	Hypoxia	5p/RGS5/RhoA axis regulated hypoxia-induced VSMCs phenotypic switch.
circulation_biomarker_diagnosis_ns	35944561	hsa-mir-142	Prostatic Neoplasms	3p has an ascendant one in prostate cancer serum samples and cells.
circRNA target	35943670	hsa-mir-600	Colorectal Neoplasms	Circ_0001821 regulated the developmental process of CRC through miR-600/ISOC1 axis.
other	35943151	hsa-let-7c	Pancreatic Carcinoma	We aimed to show that microRNAs let-7c and 7d can be used as independent predictive biomarkers for metastatic pancreatic cancer.
other	35943151	hsa-let-7d	Pancreatic Carcinoma	We aimed to show that microRNAs let-7c and 7d can be used as independent predictive biomarkers for metastatic pancreatic cancer.
other	35943150	hsa-mir-206	Carcinoma, Hepatocellular	RESULTS: The levels of miR-206 and miR-222 were significantly higher (P &lt; .05) and the level of miR-126 was lower (P &lt; .05) in patients with hepatocellular carcinoma than in healthy subjects.
other	35943150	hsa-mir-222	Carcinoma, Hepatocellular	RESULTS: The levels of miR-206 and miR-222 were significantly higher (P &lt; .05) and the level of miR-126 was lower (P &lt; .05) in patients with hepatocellular carcinoma than in healthy subjects.
other	35943150	hsa-mir-126	Carcinoma, Hepatocellular	RESULTS: The levels of miR-206 and miR-222 were significantly higher (P &lt; .05) and the level of miR-126 was lower (P &lt; .05) in patients with hepatocellular carcinoma than in healthy subjects.
target gene	35943044	hsa-mir-130a	Lung Neoplasms	Luteolin suppresses lung cancer progression through targeting the circ_0000190/miR-130a-3p/notch-1 signaling pathway.
transcription factor target	35942686	hsa-mir-424	Vesico-Ureteral Reflux	Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response.
transcription factor target	35942686	hsa-mir-516	Vesico-Ureteral Reflux	Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response.
transcription factor target	35942686	hsa-mir-34a	Vesico-Ureteral Reflux	Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response.
other	35942551	hsa-mir-633	Colorectal Neoplasms	KAI1 and miR-633 expression levels were significantly correlated with the prognosis of patients with melanoma combined with CRC.
other	35942551	hsa-mir-633	Melanoma	KAI1 and miR-633 expression levels were significantly correlated with the prognosis of patients with melanoma combined with CRC.
other	35942384	hsa-mir-1246	Chronic Periodontitis	CONCLUSION: Abnormally elevated levels of miR-1246 in saliva of patients with chronic periodontitis correlate with levels of periodontal indices, inflammatory cytokines, and protease molecules.
target gene	35942374	hsa-mir-125a	Prostatic Neoplasms	Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis.
genetics_overexpression_promote	35942174	hsa-mir-147a	Glioblastoma	In addition, cells with or without the miR-147a mimic treatment were also incubated with temozolomide (TMZ) to investigate whether miR-147a overexpression could sensitize human glioblastoma cells to TMZ chemotherapy in vitro.
genetics_overexpression_promote	35942174	hsa-mir-147a	Thyroid Cancer, Papillary	In addition, cells with or without the miR-147a mimic treatment were also incubated with temozolomide (TMZ) to investigate whether miR-147a overexpression could sensitize human glioblastoma cells to TMZ chemotherapy in vitro.
other	35941891	hsa-mir-21	Gastritis, Atrophic	CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls.
other	35941891	hsa-mir-155	Gastritis, Atrophic	We aimed to analyze the expression profile of selected miRNAs (miR21, miR142, miR223, miR155) in patients with autoimmune atrophic gastritis (AAG), patients with non-autoimmune multifocal atrophic gastritis (MAG), and healthy control subjects (HC).
other	35941891	hsa-mir-223	Gastritis, Atrophic	CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls.
other	35941891	hsa-mir-142	Gastritis, Atrophic	CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls.
target gene	35941331	hsa-mir-23b	Osteosarcoma	miRNA-23b-5p affects the proliferation, migration and invasion of osteosarcoma by targeting TMEM127.
exosome	35941326	hsa-mir-551b	Breast Neoplasms	Collectively, these findings indicated that BMSC-derived exosomal miR-551b-3p could suppress the development of breast cancer via downregulating TRIM31.
transcription factor target	35941302	hsa-mir-152	Reperfusion Injury, Renal Ischemia	Inhibition of miR
other	35941185	hsa-mir-502	Alzheimer Disease	5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages.
other	35941185	hsa-mir-877	Alzheimer Disease	5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages.
other	35941185	hsa-mir-501	Alzheimer Disease	5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages.
transcription factor target	35940944	hsa-mir-1294	Breast Neoplasms	In conclusion, MiRNA1294 acted as a tumor suppressor in BC, which might serve as a potential target for the development of anti-neoplastic therapies in BC.
transcription factor target	35940515	hsa-mir-155	Metabolic Associated Fatty Liver  Disease 	Collectively, altering high-fat dietary habits could protect against MAFLD motivated by air pollution, and miR-155 might be an effective preventive and therapeutic target for this process.
genetics_overexpression_promote	35940217	hsa-mir-122a	Reperfusion Injury, Intestinal Ischemia	Furthermore, in IEC-6 cells, a miR-122a inhibitor and an EGFR-overexpression plasmid significantly reduced pyroptosis and alleviated intestinal I/R injury via activating the EGFR-NLRP3 signaling pathway, showing that miR-122a is very essential for regulating intestinal I/R injury.
exosome	35940082	hsa-mir-195	Pre-Eclampsia	MicroRNA-195 (miR-195) was decreased in the patients with pre-eclampsia (PE), which was implicated to modulate PE. Exosomal miR-195 in hUC-MSCs alleviated hypoxia-induced cell damage through TFPI2, which might provide a potential therapeutic approach for pre-eclampsia.
lncRNA target	35940082	hsa-mir-195	Pneumonia, Mycoplasma	Moreover, tissue factor pathway inhibitor 2 (TFPI2), which was highly expressed in the placenta of PE patients, was negatively correlated with miR-195 levels.
genetics_overexpression_promote	35939970	hsa-mir-188	Prostatic Neoplasms	3p) is a direct target of hsa_circ_0102485, and cotransfection of hsa_circ_0102485 in PCa cells overexpressing miR
circRNA target	35939870	hsa-mir-144	Pulmonary Disease, Chronic Obstructive	Thus, our results conclude that the circRERE/miR3p/TLR2/MMP9 axis in COPD pulmonary monocytes is critical for CS-induced COPD and circRERE may serve as a potential target for COPD.
circRNA target	35939870	hsa-mir-144	Hamartoma Syndrome, Multiple	Thus, our results conclude that the circRERE/miR3p/TLR2/MMP9 axis in COPD pulmonary monocytes is critical for CS-induced COPD and circRERE may serve as a potential target for COPD.
epigenetics	35939560	hsa-mir-124a	Neoplasms, Second Primary	RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication.
epigenetics	35939560	hsa-mir-124a	Stomach Neoplasms	RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication.
epigenetics	35939560	hsa-mir-124a	Gastric Cancer, Metachronous	RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication.
circulation_biomarker_diagnosis_up	35939376	hsa-mir-19b	Shock, Hemorrhagic	METHODS: Blood samples from HS patients (blood pressure <90 mm Hg and >/=2 U blood) were collected upon admission, completion of hemostasis, and after 24 hours for miR-19b (quantitative reverse transcription PCR) and syndecan-1 (enzyme-linked immunosorbent assay) and compared with controls and minimally injured (Injury Severity Score, </=9).
circulation_biomarker_diagnosis_ns	35938956	hsa-mir-448	Multiple Myeloma	Besides, we observed that the abundance of miR-448 in the plasma of newly diagnosed MM patients was positively correlated with the proportion of plasma cells (PC) in the bone marrow and the concentration of serum M protein (MP), respectively.
circulation_biomarker_diagnosis_up	35938736	hsa-mir-148a	Lupus Erythematosus, Systemic	The Higher levels of circulating miR-148a in the SLE samples compared with the HCs suggest that this miRNA could be a reliable biomarker for SLE patients (with or without LN).
circulation_biomarker_diagnosis_up	35938736	hsa-mir-148a	Lupus Nephritis	The Higher levels of circulating miR-148a in the SLE samples compared with the HCs suggest that this miRNA could be a reliable biomarker for SLE patients (with or without LN).
lncRNA target	35938691	hsa-mir-497	Esophageal Squamous Cell Carcinoma	Importantly, we uncovered that miR-497 upregulation suppressed ESCC cell growth and tumor growth by inhibiting Smurf2.
circulation_biomarker_diagnosis_ns	35938548	hsa-mir-16	COVID-19	Thrombosis-related circulating miR
exosome	35938412	hsa-mir-150	Femur Head Necrosis	A rat model was established to assess the effects of exosomal miR-150 on ONFH in vivo.
genetics_overexpression_promote	35938134	hsa-mir-171e	Chills	The results showed that overexpression of Sly-miR171e (miR171e-OE) promoted postharvest chilling injury (CI) of tomato fruit at the mature red (MR) and mature green (MG) stage.
circulation_biomarker_diagnosis_ns	35938021	hsa-mir-138	Carcinoma, Renal Cell	3p) in serum were significantly dysregulated in RCC patients.
circulation_biomarker_diagnosis_ns	35938021	hsa-mir-363	Carcinoma, Renal Cell	3p) in serum were significantly dysregulated in RCC patients.
circulation_biomarker_diagnosis_ns	35938021	hsa-mir-18a	Carcinoma, Renal Cell	3p) in serum were significantly dysregulated in RCC patients.
circulation_biomarker_diagnosis_ns	35938021	hsa-mir-181b	Carcinoma, Renal Cell	3p) in serum were significantly dysregulated in RCC patients.
circulation_biomarker_diagnosis_ns	35938021	hsa-mir-200a	Carcinoma, Renal Cell	3p) in serum were significantly dysregulated in RCC patients.
other	35937995	hsa-mir-125a	uterine corpus endometrial carcinoma	The ceRNA network also identified lncRNA XIST/miR-125a-5p/CDKN2A regulatory axis for UCEC. The ceRNA network also identified that lncRNA XIST/miR-125a-5p/CDKN2A regulatory axis may be involved in the progression of UCEC.
other	35937842	hsa-mir-182	Obesity	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937842	hsa-mir-433	Metabolic Diseases	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937842	hsa-mir-182	Metabolic Diseases	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937842	hsa-mir-153	Metabolic Diseases	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937842	hsa-mir-433	Obesity	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937842	hsa-mir-153	Obesity	3p were under-expressed in the OBM patients with elevated HbA1c levels.
other	35937806	hsa-let-7g	Osteoporosis	The miRNAs-genes network showed that has-let-7g might play an important role in the common mechanisms between osteoporosis and atherosclerosis.
other	35937806	hsa-let-7g	Atherosclerosis	The miRNAs-genes network showed that has-let-7g might play an important role in the common mechanisms between osteoporosis and atherosclerosis.
other	35937783	hsa-mir-155	COVID-19	CONCLUSION: MiR-125b-5p, miR5p, STAT3, and TRIM32 could be useful biomarkers to predict the time nodes of the acute, turn-negative, and recovery stages of COVID-19.
other	35937783	hsa-mir-125b	COVID-19	CONCLUSION: MiR-125b-5p, miR5p, STAT3, and TRIM32 could be useful biomarkers to predict the time nodes of the acute, turn-negative, and recovery stages of COVID-19.
genetics_GWAS	35937778	hsa-mir-20a	Obesity	3p (p < 0.04), and the genetic predisposition for endurance and/or strength and obesity risk (ACE, ACTN3, and FTO), as well as between miRNAs and the body composition (p < 0.05).
lncRNA target	35937409	hsa-mir-374c	Uterine Cervical Neoplasms	Data of rescue assays proved that LINC00707 could promote CC cell malignancy via the miR-374c-5p/SDC4 axis, which revealed a potential treatment option for CC.
lncRNA target	35937000	hsa-mir-133a	Myocardial Reperfusion Injury	HAGLR promoted myocardial I/R injury by inhibiting miR-133a-3p to promote MAPK1 expression.
target gene	35936987	hsa-mir-623	Triple Negative Breast Neoplasms	miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells.
other	35936736	hsa-mir-1	Adenocarcinoma of Lung	Furthermore, our results also identified and verified the ceRNA of cuproptosis-related lncRNA MIR31HG/miR-193a-3p/TNFRSF21 regulatory axis using bioinformatics tools.
lncRNA target	35936736	hsa-mir-193a	Adenocarcinoma of Lung	In a word, lncRNA MIR31HG acts as an oncogene in LUAD by targeting miR-193a-3p to modulate TNFRSF21, which may be beneficial to the gene therapy of LUAD.
transcription factor target	35936681	hsa-mir-217	Carcinoma, Renal Cell	We found that miR-217 is differentially expressed in all contrasts; however, its targets were different depending on the ccRC stage.
transcription factor target	35936390	hsa-mir-145	Esophageal Neoplasms	3p may be a tumor suppressor in EC, and miR
exosome	35936223	hsa-mir-369	Fibrous Dysplasia, Polyostotic	Our research also showed that CD44+/CD105+ HuAFSC-exosomes carrying miR3p could specifically downregulate the expression of YAF2, inhibit the stability of PDCD5/p53, and reduce the apoptosis of ovarian granulosa cells (OGCs), thereby exerting therapeutic effects on POF.
other	35936219	hsa-mir-494	Parkinson Disease	3p significantly promotes ferroptosis by regulating the REST/SP1/ACSL4 axis in PD.
other	35936072	hsa-mir-128	Precursor Cell Lymphoblastic Leukemia-Lymphoma	An electrochemical nanocomposite-based aptasensor is fabricated for the determination of miRNA-128 concentration as the acute lymphoblastic leukemia (ALL) biomarker for the first time.
lncRNA target	35935584	hsa-mir-199a	Hypertension	CONCLUSION: miR-199a-5p may relieve OSAS-related hypertension by targeting HIF-1alpha and be a novel potential therapeutic target.
lncRNA target	35935584	hsa-mir-199a	Sleep Apnea, Obstructive	CONCLUSION: miR-199a-5p may relieve OSAS-related hypertension by targeting HIF-1alpha and be a novel potential therapeutic target.
lncRNA target	35935583	hsa-mir-6745	Breast Neoplasms	Mechanistically, LINC01574 competitively binds with miR-6745 to prevent the degradation of TTYH3, thereby promoting the development of BC. CONCLUSION: Our results unmasked a novel LINC01574/miR-6745/TTYH3 regulatory axis in BC progression and suggested that LINC01574 might be a promising prognostic indicator and therapeutic target for patients with BC.
circulation_biomarker_prognosis_up	35935308	hsa-mir-149	Prostatic Neoplasms	CONCLUSION: High expression of serum miRNA-149 is associated with PCa patients.
circulation_biomarker_diagnosis_ns	35935307	hsa-mir-130a	Carcinoma, Hepatocellular	Vitamin C combined with growth inhibitor was effective in the treatment of cirrhotic UGIB, which could effectively shorten the hemostasis time, reduce the transfusion volume and portal blood flow, and improve miR-130a, NO, and liver function levels of patients, with higher safety, and is worthy of clinical promotion.
circulation_biomarker_diagnosis_ns	35935307	hsa-mir-130a	Gastrointestinal Hemorrhage	Vitamin C combined with growth inhibitor was effective in the treatment of cirrhotic UGIB, which could effectively shorten the hemostasis time, reduce the transfusion volume and portal blood flow, and improve miR-130a, NO, and liver function levels of patients, with higher safety, and is worthy of clinical promotion.
exosome	35934785	hsa-mir-4474	Carcinoma, Hepatocellular	3p/ALOX15 and EMT axes and it promoted the expression of CTLA-4 in HSCs and PD-L1 in HCC cells, thus providing insights into the mechanism of tumor aggressiveness mediated by HSC-derived exosomal circWDR25.
circulation_biomarker_diagnosis_ns	35934407	hsa-mir-92a	Colorectal Neoplasms	As a colorectal cancer (CRC)-associated miRNA biomarker, miR-92a-3p possesses higher concentration in exosomes than in serum, causing it more feasible to diagnose CRC by measuring the concentration of miR-92a-3p inside exosomes.
other	35934354	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	Therefore, we designed a lateral flow strip biosensor platform (HRCA-strip) based on the cascade nucleic acid amplification technology (HRCA) for colorimetric analysis of OSCC-associated has-microRNA 31-5p (miRNA 31). Moreover, the designed HRCA-strip platform also enabled portable detection of miRNA 31 in clinical sample which might show good potential for early clinical diagnosis of OSCC.
circulation_biomarker_prognosis_ns	35934321	hsa-mir-372	Male Germ Cell Tumor	Detection of serum embryonic miRNAs miR-371a-3p and miR3p has been proposed to aid in diagnosis, prognosis, and management of patients with testicular germ cell tumors (GCTs).
circulation_biomarker_prognosis_ns	35934321	hsa-mir-371a	Male Germ Cell Tumor	Detection of serum embryonic miRNAs miR-371a-3p and miR3p has been proposed to aid in diagnosis, prognosis, and management of patients with testicular germ cell tumors (GCTs).
other	35934101	hsa-mir-1	Hypertension	We recently showed that miR5p promoted oxidative stress in spontaneously hypertensive rats.
transcription factor target	35934101	hsa-mir-1	Genetic Diseases, Inborn	Meanwhile, FNDC5 deficiency prevented the effects of miR5p inhibitor on VSMC proliferation and migration in Ang II-treated VSMCs.
genetics_overexpression_promote	35933883	hsa-mir-9	Carcinoma, Non-Small-Cell Lung	RT-qPCR was conducted to reveal that MIR9-3HG was observably overexpressed in LUSC cells.
lncRNA target	35933783	hsa-mir-135b	Osteoarthritis	Our previous research demonstrated that BMSCs-Exo(TGF-beta1) attenuated cartilage damage in osteoarthritis (OA) rats through carrying highly expressed miR-135b.
circulation_biomarker_prognosis_up	35933505	hsa-mir-411	Cerebral Infarction, Acute	RESULTS: Serum miR
tissue_expression_up	35933332	hsa-mir-92a	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-203a	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-15b	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-145	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-100	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-521	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-let-7d	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-196a	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-92a	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-521	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-200a	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1914	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-205	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-205	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1914	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-192	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1266	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1266	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-638	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-638	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-100	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-152	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1290	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-1290	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-152	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-196a	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-9	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-34a	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-15b	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-16-2	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-425	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-125b	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-16-2	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-2861	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-497	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-2861	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-let-7d	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-125b	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-497	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-203a	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-425	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-214	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-192	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-218	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-9	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-218	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-214	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-145	Precancerous Conditions	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-34a	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
tissue_expression_up	35933332	hsa-mir-200a	Uterine Cervical Neoplasms	Thirty three microRNAs were evaluated in the eligible studies and 17 (miR-196a, miR
circRNA target	35933226	hsa-mir-212	Periodontitis	CONCLUSIONS: Circ_0099630 curbed PDLC proliferation and osteogenic differentiation through elevating SPRY1 expression via sponging miR5p in periodontitis.
genetics_overexpression_promote	35933079	hsa-mir-431	Arthritis, Rheumatoid	FSTL1 overexpression largely overturned miR
genetics_overexpression_promote	35932495	hsa-mir-299	Urinary Bladder Neoplasms	3p was confirmed to bind with PTAR and its overexpression suppressed malignant behaviors of BC cells.
transcription factor target	35932362	hsa-mir-223	Acute Lung Injury	3p loaded in BALF-exo alleviates ALI by targeting STK39 in alveolar macrophages.
other	35931990	hsa-mir-125b-1	Periodontitis	3p expressions may be associated with the pathogenesis of periodontitis.
genetics_knock down_suppress	35931919	hsa-mir-224	Atherosclerosis	Knockdown of HCG11 alleviated cell pyroptosis and inflammation induced by ox-LDL via targeting the miR3p/JAK1 axis, indicating that HCG11 could be the latent target of diagnosis or treatment for AS.
circulation_biomarker_diagnosis_ns	35931409	hsa-mir-335	Polycystic Ovary Syndrome	The level of circulating miR
genetics_overexpression_suppress	35930907	hsa-mir-204	Esophageal Squamous Cell Carcinoma	5p could downregulate APLN level and its overexpression reduced the effect of APLN on EC cell functions.
transcription factor target	35930829	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: NMT1 and NMT2 can act as potential tumor suppressors in NSCLC, and the inhibition of miR-182 expression or therapeutic NMTs replenishment may be a promising treatment option for patients with NSCLC.
lncRNA target	35930398	hsa-mir-34a	Osteoarthritis	It was found that PMS2L2 over-expression caused increased miR-34a expression in OA patient chondrocytes but not in cells from healthy controls. Based on the findings that PMS2L2 is down-regulated during ongoing states of OA, and that changes in PMS2L2 expression can lead to increases in chondrocyte expression of miR-34a - resulting in inhibition of chondrocyte proliferation in OA.
other	35930289	hsa-mir-1910	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
other	35930289	hsa-mir-203b	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
other	35930289	hsa-mir-1273	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
other	35930289	hsa-mir-130b	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
other	35930289	hsa-mir-127	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
other	35930289	hsa-mir-4632	Dry Eye Syndromes	3p; all p < 0.049; fold regulation range = 1.43-1.67).
exosome	35930171	hsa-mir-338	Prostatic Neoplasms	Exosomal circKDM4A promoted PC malignant progression by the miR
lncRNA target	35930101	hsa-mir-137	Anorectal Malformations	In conclusion, aberrantly high circJag1 expression promotes epithelial apoptosis by suppressing the canonical Wnt/beta-catenin pathway via the miR
exosome	35930100	hsa-mir-199a	Atherosclerosis	CONCLUSION: EV-packaged inhibited miR-199a-5p from macrophages expedites endothelial cell pyroptosis and further accelerates atherosclerosis through the SMARCA4/PODXL/NF-kappaB axis, providing promising targets and strategies for the prevention and treatment of atherosclerosis.
lncRNA target	35929906	hsa-mir-218	Thyroid Cancer, Papillary	CONCLUSION: MCM3AP-AS1 may serve as a competing endogenous RNA of miR-218 to upregulate GLUT1 in PTC, thereby promoting cell proliferation. The MCM3APAS1/ miR-218/GLUT1 pathway characterized in the present study might serve as a potential target to treat PTC.
genetics_overexpression_suppress	35929837	hsa-mir-338	Adenocarcinoma of Lung	3p overexpression can modulate the ERK1/2 signaling pathway by targeting MAP3K2, thus inhibiting the migration, invasion and proliferation of human LUAD cells.
lncRNA target	35929619	hsa-mir-4443	Neurodegenerative Diseases	In addition, human microRNA-4433 (hsa-miR-4443), which targets 18 co-DEGs, was the only 1 co-up-regulated microRNA identified in the cortex of neurodegenerative diseases. Hsa-miR-4443 targets 18 co-DEGs and may be a potential molecular mechanism in neurodegenerative diseases' occurrence and development.
genetics_knock down_promote	35929525	hsa-mir-622	Stomach Neoplasms	Loss-of-function experiment revealed that overexpression of miR-622 decreased proliferation, migration, and invasion while it increased apoptosis in GC cells.
exosome	35929514	hsa-mir-124	Glioma	Thus, biocarrier NSCEXOs loaded with miR1243p suppressed glioma growth via the EXOmiR1243p/FLOT2/AKT1 pathway.
other	35929425	hsa-mir-146a	Neointimal   Hyperplasia	A single systemic administration of miR146a-5p attenuated NIH and vessel remodeling in a carotid artery balloon injury model in both male and female rats in vivo. Therefore, miR146a-5p delivery to the injury site demonstrated therapeutic potential against NIH after revascularization.
lncRNA target	35929417	hsa-mir-346	Leukemia	Interestingly, lncRNA-412.25 could directly bind to miR-346, which can target the gene of leukemia inhibitory factor (LIF).
lncRNA target	35929185	hsa-mir-339	Melanoma	CONCLUSION: Silencing LINC00665 inhibits in vitro CM progression and induces apoptosis via the miR
lncRNA target	35928970	hsa-mir-195	Stomach Neoplasms	miR-195/JAK2 may be a new molecular target for the treatment of gastrointestinal tumors.
circulation_biomarker_diagnosis_up	35928925	hsa-mir-155	Epilepsy	CONCLUSION: The expression of miR-155 in serum exosomes in children with epilepsy is up-regulated, and its level is related to the course of the disease and the degree of abnormal EEG, so miR-155 in serum exosomes may be used as a biomarker for the diagnosis and assessment of the severity of epilepsy.
target gene	35928803	hsa-mir-29b	Prostatic Neoplasms	miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis.
genetics_knock down_suppress	35928754	hsa-mir-149	Diabetic Nephropathies	5p, HL-1 cells were infected with the lentivirus of HFRL with or without simultaneous knockdown of miR
lncRNA target	35928615	hsa-mir-145	Esophageal Squamous Cell Carcinoma	5p acts as a tumor suppressor microRNA in ESCC and is an important noncoding RNA in the high M2-like tumor-associated macrophage infiltration of ESCC.
transcription factor target	35928115	hsa-mir-206	Leukemia Virus, Bovine Infection	In addition, Bta-miR-206 interacted with BLV regulatory genes rex and tax by targeting their coding regions.
other	35927800	hsa-mir-9	Neurodegenerative Diseases	In degenerative NP cell models, LINC01116 could competitively bind to miR5p to elevate ZIC5 expression.
circulation_biomarker_diagnosis_up	35927714	hsa-mir-934	Asthma	Next, the expression levels of miR-3934 in peripheral blood mononuclear cells of 50 asthma patients and 50 healthy volunteers were examined by RT-qPCR methods.
lncRNA target	35927640	hsa-let-7b	Ischemic Stroke	CONCLUSION: High-frequency rTMS could alleviate ischemic stroke injury through inhibiting M1 microglia polarization via regulating let-7b-5p/HMGA2/NF-kappaB signaling pathway in MCAO models.
transcription factor target	35927544	hsa-mir-383	Brain Ischemia	Thus, the CTCF/miR5p/HDAC9 pathway may present a target for drug development against ischemic brain injury.
transcription factor target	35927544	hsa-mir-383	Brain Injury, Ischemic	Thus, the CTCF/miR5p/HDAC9 pathway may present a target for drug development against ischemic brain injury.
exosome	35927251	hsa-mir-27b	Glioblastoma	There is growing evidence supporting the implications of exosomes-shuttled microRNAs (miRs) in the phenotypes of glioblastoma stem cells (GSCs), whilst the role of exosomal miR-27b-3p remains to be established.
other	35927233	hsa-mir-219a-2	Glioblastoma	Finally, by carrying out in vitro and in vivo functional assays, we uncovered a new regulatory axis circPOSTN/miR-219a3p/STC1 that promoted GBM neovascularization by increasing vascular endothelial growth factor A (VEGFA) secretion.
transcription factor target	35927086	hsa-mir-378a	Microvascular Obstruction	SAL reduced the expression of insulin-like growth factor 1 receptor (IGF1R), and increased the expressions of PI3K and Akt, however, these alterations were blocked by miR-378a-3p inhibitor. CONCLUSIONS: miR-378a-3p might participate in the protective effect of SAL in I/R-induced myocardial apoptosis via the IGF1R/PI3K/AKT signaling pathway.
transcription factor target	35926946	hsa-mir-182	Diabetic Retinopathy	CONCLUSIONS: BAE significantly inhibited the progression of DR via molecular regulation function between miR-182/OGG1 axis and ROS/ERS.
genetics_overexpression_promote	35926796	hsa-mir-195	Uterine Cervical Neoplasms	5p was partially restored by overexpressing PFKFB4, indicating that miR
genetics_knock down_promote	35926447	hsa-mir-3168	Carcinoma, Hepatocellular	Rescue assays demonstrated that p53 knockdown abrogates the discrepancies in proliferation, self-renewal, and tumorigenicity between miR-3168 knockdown HCC cells and control HCC cells.
genetics_knock down_promote	35926312	hsa-mir-200b	Breast Neoplasms	miR-200b-3p overexpression-induced effects in BC cells were largely counteracted by the accumulation of ANLN.
exosome	35926094	hsa-mir-148a	Diabetes, Gestational	Exosomal miR
exosome	35926094	hsa-mir-192	Diabetes, Gestational	Exosomal miR
genetics_overexpression_promote	35925680	hsa-mir-155	Breast Neoplasms	Mechanistically, miR-155 overexpression in breast cancer cells upregulated their CXCL9/10/11 production, which was mediated by SOCS1 inhibition and increased phosphorylated STAT1 (p-STAT1)/p-STAT3 ratios.
other	35924788	hsa-mir-383	Carcinoma, Hepatocellular	E2F7 facilitates HCC growth by repressing miR5p transcription and sequentially promoting SP1/SOX4/Anillin axis.
lncRNA target	35924724	hsa-mir-148b	Adenocarcinoma of Lung	In addition, HOXA11-AS inhibited LUAD xenograft growth and glycolysis via upregulation of miR-148b-3p expression and downregulation of PKM2 expression in vivo.
genetics_knock down_promote	35924589	hsa-mir-582	Leukemia, Myeloid, Acute	Circ_DLEU2 knockdown suppressed cell proliferation, whereas it induced cell arrest at G0/G1 phase and cell apoptosis in AML; however, these effects were attenuated by miR
transcription factor target	35924515	hsa-mir-21	Acute Lung Injury	CONCLUSIONS: Inhibition of STAT3 hyperactivation may suppress the inflammatory response, regulate oxidative stress, improve lung permeability through regulating the expression of miR-21, which exert lung protection in HALI.
circRNA target	35924466	hsa-mir-646	Diabetes Mellitus	CONCLUSION: CircCOL1A2 silencing can suppress HG-induced migration, proliferation, angiogenesis, BRB injury and inflammation in RMECs through miR-646/FGF7 axis, suggesting the potential involvement of circCOL1A2 in DR process.
lncRNA target	35924161	hsa-mir-506	Ovarian Neoplasms	3p expression may recapitulate a BRCAness phenotype sensitizing EOC cells to chemotherapy and helping in selecting patients susceptible to DNA damaging drugs in combination with new small molecules targeting DNA-damage repair pathway.
circulation_biomarker_diagnosis_up	35924109	hsa-mir-29b	Coronary Artery Disease	At present, real-time fluorescence quantitative PCR (qRT-PCR) was used to detect the expression levels of plasma miR-let-7b and miR-29b in patients with coronary artery calcification and noncoronary artery calcification and to analyze whether the expression levels of miR-let-7b and miR-29b were different between the two groups.
other	35924109	hsa-let-7b	Coronary Artery Disease	Cardiovascular diseases seriously endanger human physical and mental health and life safety, to investigate correlation between miR-let-7b and miR-29b and coronary artery calcification of various patients.
lncRNA target	35923244	hsa-mir-525	Breast Neoplasms	5p and suppression of CSDE1 inhibited BC cell growth and induced cell apoptosis.
lncRNA target	35922673	hsa-mir-124	Rhinitis, Allergic	3p may be a promising new target in AR treatment.
exosome	35922404	hsa-mir-34b	Colorectal Neoplasms	Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p/HuR/HOXC6 axis.
other	35921387	hsa-mir-132	Hidradenitis Suppurativa	miR-132 was significantly upregulated during the inflammation phase of wound repair, enhancing the activity of STAT3 and ERK pathways that promote keratinocyte proliferation.
other	35921387	hsa-mir-192	Hidradenitis Suppurativa	The miR-192 is implicated in non-alcoholic fatty liver disease.
other	35921382	hsa-mir-204	Ovarian Neoplasms	RESULTS: The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively. CONCLUSION: The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively).
transcription factor target	35921230	hsa-mir-26a-1	Carcinoma, Non-Small-Cell Lung	In addition, we identified that miR-26A1 could function as a tumor suppressor to inhibit proliferation and metastasis of NSCLC cells. To sum up, our findings revealed that enhancer-mediated TSGs regulation occured in NSCLC, suggesting that miR-26A1 could serve as a key regulator and may be a potential therapeutic target for NSCLC.
other	35921220	hsa-mir-23a	Hypertension	The downregulation of miRNA-23a in humans affected by essential hypertension corroborate our data and point to the potential role of miRNA-23a in the regulation of mTAL function following high salt intake.
transcription factor target	35920886	hsa-mir-497	Oral Submucous Fibrosis	This study was designed to explore the role of miR-497 in arecoline (AR)-induced OSF. CONCLUSION: miR-497 inhibition may attenuate OSF by inhibiting myofibroblast transdifferentiation in BMFs via the TGF-beta1/Smads signaling pathway, indicating that miR-497 might represent an underlying target for treating OSF.
lncRNA target	35920698	hsa-mir-15a	Carcinoma, Non-Small-Cell Lung	Mechanistically, circFARSA facilitated the malignant phenotype of NSCLC cells by enhancing B7H3 expression through sponging miR-15a-5p. In conclusion, circFARSA served as a sponge of miR-15a-5p to promote tumorigenesis and development of NSCLC by upregulation of B7H3 expression, which provided evidence of circFARSA maybe act as a novel therapeutic target for NSCLC.
other	35920610	hsa-mir-769	Carcinoma, Non-Small-Cell Lung	5p/EGFR axis.
other	35920438	hsa-mir-495	Myocardial Infarction	This work unveiled an innovative axis of circ-CBFB/miR3p/VDAC1 in H/R-challenged cardiomyocyte damage, exerting its potential in providing new thoughts in acute myocardial infarction management.
circRNA target	35920438	hsa-mir-495	Mitochondrial Diseases	Collectively, these observations demonstrated that absence of circ-CBFB offered cardio-protection against H/R-triggered cardiomyocyte injury by relieving apoptosis, oxidative stress, and mitochondria dysfunction through miR3p/VDAC1 axis.
genetics_knock down_promote	35920365	hsa-mir-383	Stomach Neoplasms	CONCLUSIONS: Knockdown of circLRCH3 alleviated OXA resistance of GC by modulating the miR
lncRNA target	35920180	hsa-mir-1	Pulmonary Hypertension, Thromboembolic, Chronic	In conclusion, GAS5 promoted SPinduced autophagy through miRNA315p/NAT8L signaling pathways in vitro and in vivo and GAS5 may be a promising molecular marker for therapies of CTEPH.1.
other	35919038	hsa-mir-1246	Atrial Fibrillation	HCK/CXCR4 regulatory axises may be associated with the immune mechanism of AF.
other	35919038	hsa-mir-623	Atrial Fibrillation	HCK/CXCR4 regulatory axises may be associated with the immune mechanism of AF.
circRNA target	35918767	hsa-mir-512	Prostatic Neoplasms	5p/XRCC5 signaling with Quercetin may help physicians to develop a novel RT to better suppress the progression of PCa.
other	35918733	hsa-mir-506	Prostatic Neoplasms, Castration-Resistant	CONCLUSION: Together, our results showed that a S100A9/circMID1/miR3p/MID1 axis existed in MDSC-Exo-regulated CRPC progression, which provided novel insights into MDSC-Exo regulatory mechanisms in CRPC progression.
lncRNA target	35918619	hsa-mir-548p	Breast Neoplasms	Our research demonstrated that LINC00052 is highly expressed in breast cancer and promotes breast cancer proliferation, migration, and invasion via the miR-548p/Notch2/Pyk2 axis.
genetics_overexpression_promote	35918602	hsa-mir-96	Carcinoma, Hepatocellular	5p transfection promoted proliferation, migration and invasion of SMMC-7721 and MHCC-97H hepatoma cells; whereas the function of oncogenic microRNA-96 was significantly inhibited in GPM6A-overexpressed hepatoma cells.
lncRNA target	35918398	hsa-mir-370	Diabetic Nephropathies	In conclusion, inhibition of circIgfbp2 alleviated mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after TBI through the miR3p/BACH1/HO-1 axis.
lncRNA target	35918398	hsa-mir-370	Anxiety Disorders	In conclusion, inhibition of circIgfbp2 alleviated mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after TBI through the miR3p/BACH1/HO-1 axis.
lncRNA target	35918398	hsa-mir-370	Brain Injuries, Traumatic	In conclusion, inhibition of circIgfbp2 alleviated mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after TBI through the miR3p/BACH1/HO-1 axis.
other	35918371	hsa-mir-93	Lentivirus Infections	5p was altered in BL of SRLV-SN goats.
lncRNA target	35917938	hsa-mir-200	Drug-Induced Kidney Injury	SIGNIFICANCE: Prophylactic administration of LCZ protected against CP-induced nephrotoxicity via up-regulating apelin-13/ACE2, miR-200, and down-regulating TGF-beta/SMAD 2/3 and miR-192.
lncRNA target	35917938	hsa-mir-192	Drug-Induced Kidney Injury	SIGNIFICANCE: Prophylactic administration of LCZ protected against CP-induced nephrotoxicity via up-regulating apelin-13/ACE2, miR-200, and down-regulating TGF-beta/SMAD 2/3 and miR-192.
other	35917800	hsa-mir-6875	Lung Neoplasms	Furthermore, except for the lowly expressed miR5p in lung cancer tissue, the other 4 miRNAs all expressed highly in cancer patients.
genetics_overexpression_suppress	35917658	hsa-mir-494	Carcinoma, Non-Small-Cell Lung	Circ_0000317 overexpression restrained the proliferation, migration, and invasion of NSCLC cells, but co-transfection of miR
other	35917643	hsa-mir-661	Esophageal Squamous Cell Carcinoma	Its promotion of ESCC progression is achieved by mediating the miR-661/HDAC11 axis.
other	35917569	hsa-mir-154	Carcinoma, Hepatocellular	Here, we for the first time demonstrated that miR-3154 was elevated in HCC and liver cancer stem cells (CSCs).
transcription factor target	35917569	hsa-mir-514	Carcinoma, Hepatocellular	In conclusion, we reveal the crucial role of miR-3514 in HCC progression and lenvatinib response, suggesting potential therapeutic targets for HCC.
lncRNA target	35917232	hsa-mir-20a	Cartilage Diseases	Accordingly, the knock-down of miR-20a-5p promoted cartilage regeneration in the osteochondral defects of rats. CONCLUSIONS: miR-20a-5p could target SMAD6 to activate NF-kappaB signaling pathway, and thus inhibit chondrogenesis of hDPSCs, which provided promising therapeutic target for cartilage defects clinically.
genetics_knock down_promote	35917008	hsa-mir-582	Leukemia, Myeloid, Acute	Circ_0035381 knockdown repressed cell proliferation and promoted cell apoptosis and mitochondrial damage via regulating the miR
genetics_knock down_promote	35916967	hsa-mir-411	Colorectal Neoplasms	5p absence or PRRG4 overexpression could rescue circ_0056618 knockdown-induced inhibition on proliferation, migration/invasion, and EMT in CRC cells.
other	35916504	hsa-mir-148b	Lung Neoplasms	In this study, we utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in human lung cancer (A549) cells.
genetics_overexpression_promote	35916453	hsa-mir-1322	Squamous Cell Carcinoma of Head and Neck	Overexpression of MED1 in OTSCC cells partially reversed the tumor suppression functions of si-circFNDC3B or miR-1322 mimics in vitro.
other	35916080	hsa-mir-873	Carcinoma, Non-Small-Cell Lung	Conclusion: This study revealed a novel machinery of circTTBK2/miR5p/TEAD1/DERL1 for NSCLC tumorigenesis.
circulation_biomarker_diagnosis_ns	35915976	hsa-mir-150	Lymphoma, Large B-Cell, Diffuse	The aim of the current study is to detect the biochemical and clinical impacts of miR-150 and miR-21 expression levels in DLBCL. Serum miR-150 and serum miR-21 can be used as diagnostic markers for DLBCL patients, but miR-21 is more sensitive than miR-150.
other	35915613	hsa-mir-19	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	TCGA analysis conferred a negative correlation between miR-19 level and leukemia patients' survival.
exosome	35915541	hsa-mir-155	Orchitis	Overall, we demonstrate that miR5p delivered by IT-exos plays an important role in the activation of TM1 in UPEC-induced orchitis.
genetics_overexpression_promote	35915318	hsa-mir-182	Hypertension, Pulmonary	In contrast, liver-specific overexpression of miR
lncRNA target	35915245	hsa-mir-200a	Urinary Bladder Neoplasms	Collectively, these results suggest that targeting the newly identified ADAR2/circ_0001005/miR-200a-3p/PD-L1 pathway to impact antitumor immunity may suppress progression and boost immunotherapeutic efficacy in BCa.
other	35914612	hsa-mir-145	Colorectal Neoplasms	5p was decreased in CRC samples compared with adjacent tissues (p < 0.05).
other	35914592	hsa-let-7	Cardiotoxicity	Furthermore, let-7a-5p regulated the cardiac hypertrophy signaling pathway, suggesting mechanisms of miRNA of let-7 family mediating cross-generational cardiotoxicity of antibiotics in zebrafish.
other	35914592	hsa-let-7a	Cardiotoxicity	Furthermore, let-7a-5p regulated the cardiac hypertrophy signaling pathway, suggesting mechanisms of miRNA of let-7 family mediating cross-generational cardiotoxicity of antibiotics in zebrafish.
genetics_overexpression_suppress	35914373	hsa-mir-532	Ovarian Neoplasms	3p-overexpressed ovarian cancer cells.
lncRNA target	35914269	hsa-mir-372	Colorectal Neoplasms	3p/EPHA2 in 5-Fu and DDP resistance of CRC, which may provide potential therapeutic targets for improving the chemosensitivity of CRC.
circRNA target	35913598	hsa-mir-485	Inflammation	Circ_0008529 targeted the miR5p/WNT2B pathway to regulate HG-induced HK-2 cell apoptosis and inflammatory injury, suggesting that circ_0008529 was a vital regulator in DN development.
lncRNA target	35912960	hsa-mir-133a	Squamous Cell Carcinoma of Head and Neck	miR-133a-5p was identified as a downstream target of XIST, which was downregulated in OSCC tissues.
lncRNA target	35912726	hsa-mir-96	Prostatic Neoplasms	5p promotes the migration and invasion of PCa by targeting NDRG1 and regulating the NF-kappaB pathway.
lncRNA target	35912726	hsa-mir-96	Prostate Cancer 	5p promotes the migration and invasion of PCa by targeting NDRG1 and regulating the NF-kappaB pathway.
genetics_overexpression_promote	35912216	hsa-mir-374b	Carcinoma, Ovarian Epithelial	HMGB3 overexpression weakened antitumor effects of GLA and miR-374b-5p in EOC cells.
transcription factor target	35912153	hsa-mir-135a	Acute Lung Injury	This investigation probed miR-135a-5p/TBK1 axis within ALI together with its new therapeutic target. CONCLUSION: miR-135a-5p targeted TBK1 to regulate inflammatory/oxidative stress responses in ALI.
genetics_overexpression_promote	35912140	hsa-mir-21	Endometrial Neoplasms	5p mimics reverses the effect of lncRNA NBAT1 overexpression on the proliferation and migration of EC cells.
circulation_biomarker_diagnosis_up	35912051	hsa-mir-1228	Colorectal Neoplasms	CONCLUSIONS: miR-1228 is recommended as a better endogenous control in quantification of circulating miRNAs in CRC patients.
genetics_knock down_promote	35912010	hsa-mir-423	Prostatic Neoplasms	While FEMD3 knockdown would reverse the repressive effect of silencing microRNA
exosome	35911777	hsa-mir-183	Pancreatitis	Therefore, a vicious cycle might exist between injured ACs and M1 macrophage polarization, which is fulfilled by EV-transported miR
other	35911380	hsa-mir-125b	Carcinoma, Hepatocellular	Finally, MIR4435-2HG/CYTOR were observed to be the most promising upstream lncRNAs for the miR-125b-5p/RRM2 axis in HCC.
other	35911380	hsa-mir-4435-2	Carcinoma, Hepatocellular	Finally, MIR4435-2HG/CYTOR were observed to be the most promising upstream lncRNAs for the miR-125b-5p/RRM2 axis in HCC.
lncRNA target	35910856	hsa-mir-15b	Diabetic Nephropathies	This study investigated the effect of MALAT1 on DN through the regulation of miR-15b-5p/TLR4 signaling.
lncRNA target	35910838	hsa-mir-654	Thrombosis	5p via SonoVue microbubbles was able to inhibit arterial thrombosis and stenosis by targeting TCF21.
lncRNA target	35910838	hsa-mir-654	Constriction, Pathologic	5p via SonoVue microbubbles was able to inhibit arterial thrombosis and stenosis by targeting TCF21.
lncRNA target	35910231	hsa-mir-378a	Stomach Neoplasms	Importantly, we found that the KCNQ1OT1/miR-378a-3p/RBMS1 axis may play a vital role in the diagnosis and prognosis of GC patients based on Cox regression analyses. Conclusion: Our findings suggest that the KCNQ1OT1/miR-378a-3p/RBMS1 axis may be a potential prognostic biomarker and therapeutic target for GC.
circulation_biomarker_diagnosis_ns	35910206	hsa-mir-27a	Ovarian Neoplasms	Conclusions: The serum exosomal DIO3OS-hsa-miR-27a-3p-HOXA10 competitive endogenous signaling axis affects ovarian cancer development and disease survival by targeting dysregulated transcriptional pathways in cancer.
genetics_knock down_promote	35909905	hsa-mir-42	Carcinoma, Squamous Cell, Cutaneous	The effect of overexpression or knockdown of miR
other	35909588	hsa-mir-3666	Polycystic Ovary Syndrome	These results indicate the role of miR-3666/IGF-1 in LEC-EMT that offers new strategies for the therapy and prevention of PCO.
epigenetics	35909537	hsa-mir-199a	Diabetes, Gestational	This suggests that miR-199a-5p may regulate the glucose pathway by regulating methylation levels, leading to the occurrence of GDM.
other	35909518	hsa-mir-130b	Diabetic Nephropathies	Based on the analysis of the ceRNA network, five differentially expressed lncRNAs (DElncRNAs) (SNHG6, KCNMB2-AS1, LINC00520, DANCR, and PCAT6), five DEmiRNAs (miR-130b-5p, miR-326, miR-374a-3p, miR-577, and miR-944), and five DEmRNAs (PTPRC, CD53, IRF8, IL10RA, and LAPTM5) were demonstrated to be related to the pathogenesis of DN.
other	35909518	hsa-mir-326	Diabetic Nephropathies	Based on the analysis of the ceRNA network, five differentially expressed lncRNAs (DElncRNAs) (SNHG6, KCNMB2-AS1, LINC00520, DANCR, and PCAT6), five DEmiRNAs (miR-130b-5p, miR-326, miR-374a-3p, miR-577, and miR-944), and five DEmRNAs (PTPRC, CD53, IRF8, IL10RA, and LAPTM5) were demonstrated to be related to the pathogenesis of DN.
other	35909518	hsa-mir-374a	Diabetic Nephropathies	Based on the analysis of the ceRNA network, five differentially expressed lncRNAs (DElncRNAs) (SNHG6, KCNMB2-AS1, LINC00520, DANCR, and PCAT6), five DEmiRNAs (miR-130b-5p, miR-326, miR-374a-3p, miR-577, and miR-944), and five DEmRNAs (PTPRC, CD53, IRF8, IL10RA, and LAPTM5) were demonstrated to be related to the pathogenesis of DN.
lncRNA target	35909488	hsa-mir-18b	Retinoblastoma	CONCLUSION: circ_0084811 modulated RB progression via the miR-18a-5p/miR-18b-5p/E2F5 axis.
lncRNA target	35909488	hsa-mir-18a	Retinoblastoma	CONCLUSION: circ_0084811 modulated RB progression via the miR-18a-5p/miR-18b-5p/E2F5 axis.
genetics_overexpression_promote	35909477	hsa-mir-149	Osteosarcoma	Subsequently, the experimental results showed that miR-149 could target negative regulation of NOTCH1, and further overexpression of NOTCH1 in cells with high miR-149 expression could promote the growth and metastasis of osteosarcoma cells in vitro.
other	35908953	hsa-mir-558	Pre-Eclampsia	Circ_0043610 induced RYBP production to promote trophoblast dysfunction by binding to miR-558 in PE.
other	35908953	hsa-mir-558	Trophoblast Dysfunction	Circ_0043610 induced RYBP production to promote trophoblast dysfunction by binding to miR-558 in PE.
circRNA target	35908770	hsa-mir-375	Adenocarcinoma of Lung	This interaction facilitated the expression of the downstream target of miR-375, ACVRL1, whose upregulation inhibited the development and malignancy of LUAD. CONCLUSION: These findings demonstrate that hsa_circ_0129047 functions as a tumor inhibitor in LUAD by modulating the miR-375/ACVRL1 axis.
lncRNA target	35908276	hsa-mir-128	Prostatic Neoplasms	Mechanistically, IFIT5, a unique downstream effector of JAK-STAT1 pathway, can facilitate the acquisition of stemness properties in PCa by accelerating the turnover of specific microRNAs (such as miR-128 and -101) that can target several CSC genes (such as BMI1, NANOG, and SOX2).
virus_miRNA	35907914	ebv-mir-BART-22	Nasopharyngeal Carcinoma	EBV-miR-BART-22 directly targets the 3'-UTR of MOSPD2 mRNA to promote the EMT and metastasis of NPC cells by activating the Wnt/β-catenin signaling pathway.
circulation_biomarker_diagnosis_up	35907902	hsa-let-7d	Sepsis	In a multiple logistic regression analysis, serum miRNA hsa-let-7d-3p was found to be an independent predictor of sepsis.
other	35907786	hsa-mir-1825	Adenocarcinoma of Lung	ROC curve result showed that miR-1825 was able to distinguish preoperative breast cancer patients from healthy people and postoperative patients.
circRNA target	35907337	hsa-mir-23b	Pulmonary Disease, Chronic Obstructive	These results reveal that circXPO1 plays a role in the pathogenesis of COPD by modulating TAB3 through sponging miR-23b-3p.
circRNA target	35907337	hsa-mir-23b	Inflammation	These results reveal that circXPO1 plays a role in the pathogenesis of COPD by modulating TAB3 through sponging miR-23b-3p.
exosome	35907132	hsa-mir-15a	Ischemic Stroke	CONCLUSIONS: Conclusively, BMSC-released exosomes might carry long noncoding RNA ZFAS1 to curb oxidative stress and inflammation related to ischemic stroke, which was possibly realized through miR-15a-5p inhibition.
genetics_knock down_promote	35907010	hsa-mir-663	Lung Neoplasms	SOCS6 overexpression annulled the promotion of miR-663 on LC cell growth.
genetics_GWAS	35906386	hsa-mir-218	Leukemia	Epigenetic inactivation of SLIT2-IT1/miR-218 by SLIT2 promoter hypermethylation could be a promising therapeutic target in MDS.
genetics_GWAS	35906386	hsa-mir-218	Myelodysplastic Syndromes	Epigenetic inactivation of SLIT2-IT1/miR-218 by SLIT2 promoter hypermethylation could be a promising therapeutic target in MDS.
transcription factor target	35906328	hsa-mir-193a	Brain Injury, Ischemic	Cerebral injury and neuroinflammation aggravated by miR-193a-5p inhibition were reversed by UBE2V2 silencing. In conclusion, miR-193a-5p protects against cerebral ischemic injury by restoring neutrophil N2 phenotype-associated neuroinflammation suppression, likely, in part, via UBE2V2 induction.
lncRNA target	35906204	hsa-mir-184	Diabetes Mellitus, Type 2	3p levels in human T2D pancreatic islets, whereas its direct target CREB regulated transcription coactivator 1 (CRTC1) was increased and protects beta-cells from lipotoxicity- and inflammation-induced apoptosis.
genetics_overexpression_suppress	35905576	hsa-mir-448	Breast Neoplasms	Upregulation of ZEB1 expression in cells overexpressing miR-448 can partially reverse the inhibition of BC cell growth induced by miR-448.
target gene	35905561	hsa-mir-548c	Stomach Neoplasms	Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1.
circulation_biomarker_diagnosis_up	35905021	hsa-mir-193a	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-128	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-205	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-25	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-7	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-9	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-15b	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-210	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-1	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-100	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-10a	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-16	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-10b	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-106b	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-200b	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-143	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
circulation_biomarker_diagnosis_up	35905021	hsa-mir-296	Tuberculosis, Pulmonary	3p in plasma samples of patients with pulmonary TB (p < 0.05).
genetics_knock down_suppress	35904670	hsa-mir-99a	Glioblastoma	Loss-of-function experiments demonstrated that MIR99AHG silencing enhanced TMZ sensitivity of GBM both in vitro and in vivo.
exosome	35904534	hsa-mir-21	Carcinoma, Hepatocellular	Exosome-transferred miR-21 might serve as a potential prognostic biomarker in HCC.
lncRNA target	35904444	hsa-mir-15a	Fanconi Anemia	Gene ontology analyses and identification of additional FA/HR factors as targets of miR-15a-5p, miR3p and miR-544a strongly suggested the widespread influence of these microRNAs on HR.
lncRNA target	35904444	hsa-mir-544a	Fanconi Anemia	Gene ontology analyses and identification of additional FA/HR factors as targets of miR-15a-5p, miR3p and miR-544a strongly suggested the widespread influence of these microRNAs on HR.
lncRNA target	35904444	hsa-mir-494	Fanconi Anemia	Gene ontology analyses and identification of additional FA/HR factors as targets of miR-15a-5p, miR3p and miR-544a strongly suggested the widespread influence of these microRNAs on HR.
circulation_biomarker_diagnosis_up	35904423	hsa-mir-675	Schizophrenia	CONCLUSIONS: We identified global miRNA changes in plasma EXO derived from patients with SCZ that were relevant to neuronal functions, among which, hsa-miR3p expression was upregulated by clozapine treatment.
transcription factor target	35904181	hsa-mir-98	Osteoporosis-pseudoglioma syndrome	In conclusion, the findings of the present study suggested that the inhibition of miR985p expression may activate PI3K/AKT/GSK3beta signaling to promote HGinduced suppression of preosteoblast viability and differentiation by targeting BMP2, which provides a novel insight into future potential molecular markers for OP treatment.
lncRNA target	35904180	hsa-mir-3180	Squamous Cell Carcinoma of Head and Neck	miR3180 inhibition reversed the lncKRT16P6 depletioninduced attenuation of TSCC malignancy and GATAD2A depletion reversed the miR3180 silencinginduced enhancement of TSCC malignancy. In summary, the present study revealed a potential competitive endogenous RNA (ceRNA) regulatory pathway in which lncKRT16P6 modulates GATAD2A expression by binding miR3180, ultimately promoting tumorigenesis and metastasis in TSCC.
genetics_knock down_promote	35904110	hsa-mir-650	Arthritis, Rheumatoid	Silencing of miR-650 could overturned above effects of circ_0025908 knockdown in FLS-RA, whereas its overexpression could mimic those effects by downregulating SCUBE2.
transcription factor target	35904008	hsa-mir-152	Vitreoretinopathy, Proliferative	These results indicate that miRNA-152 in HPAECs may be an excellent therapeutic target against PVR, and that framework nucleic acids with carefully designed sequences are promising nanomedicines for noncancerous cells and diseases.
lncRNA target	35903964	hsa-mir-761	Pulmonary Fibrosis	Whereas inhibition of miR-761 attenuated the degree of RIPF and inhibited fibroblast activation.
genetics_overexpression_suppress	35903922	hsa-mir-34a	Urinary Bladder Neoplasms	Moreover, the treatment of BC cells with CQ and Baf-A1 inhibited hsa-microRNA-34a (miR-34a) expression and miR-34a overexpression in BC cells prevented the autophagy blockade-induced PD-L1 expression; a negative correlation between miR-34a and PD-L1 expression was observed during treatment with autophagy inhibitors. Furthermore, miR-34a overexpression induced the cytotoxic activity of natural killer cells against BC cells.
genetics_GWAS	35903524	hsa-mir-21	Cardiovascular Diseases	Our research suggests that miR-21/TIPE2 pathway is involved in M1 macrophage apoptosis and inflammatory response, and genistein inhibits the progression of LPS-induced cardiovascular injury at the epigenetic level via regulating the promoter region of Vmp1 by NF-kappaB.
genetics_GWAS	35903524	hsa-mir-21	Vascular System Injuries	Our research suggests that miR-21/TIPE2 pathway is involved in M1 macrophage apoptosis and inflammatory response, and genistein inhibits the progression of LPS-induced cardiovascular injury at the epigenetic level via regulating the promoter region of Vmp1 by NF-kappaB.
circulation_biomarker_diagnosis_ns	35903462	hsa-let-7c	Melanoma	These miRNAs, including hsa-let-7c-5p, hsa-miR-130b-3p, and hsa-miR3p, and activated dendritic cells, naive CD4 T cells, M1 macrophages, and plasma cells may play vital roles in the pathogenesis of melanoma.
circulation_biomarker_diagnosis_ns	35903462	hsa-mir-130b	Melanoma	These miRNAs, including hsa-let-7c-5p, hsa-miR-130b-3p, and hsa-miR3p, and activated dendritic cells, naive CD4 T cells, M1 macrophages, and plasma cells may play vital roles in the pathogenesis of melanoma.
circulation_biomarker_diagnosis_ns	35903462	hsa-mir-142	Melanoma	These miRNAs, including hsa-let-7c-5p, hsa-miR-130b-3p, and hsa-miR3p, and activated dendritic cells, naive CD4 T cells, M1 macrophages, and plasma cells may play vital roles in the pathogenesis of melanoma.
circulation_biomarker_prognosis_up	35902998	hsa-mir-486	Lung Neoplasms	Results of subgroup analysis showed that high diagnostic efficacy might be obtained by miR-486 combined with other microRNAs (area under the curve (AUC): 0.9 (0.9-1.0)) to distinguish lung cancer patients from healthy controls (AUC: 1.0 (0.9-1.0)), especially for lung adenocarcinoma (AUC: 1.0 (1.0-1.0)) in the Asian population (AUC: 0.9 (0.9-1.0)). CONCLUSION: This study suggested circulating miR-486 combined with other microRNAs could be used as ideal biomarkers in early diagnosis and prognosis prediction for lung cancer, especially for lung adenocarcinoma in the Asian population.
exosome	35902972	hsa-mir-335	Inflammation	CONCLUSIONS: HucMSC-derived exosomal miR
genetics_overexpression_promote	35902926	hsa-mir-1178	Thyroid Cancer, Papillary	Furthermore, YWHAH overexpression overturned miR
target gene	35902921	hsa-mir-320c	Breast Neoplasms	CircPDSS1 promotes the proliferation, invasion, migration, and EMT of breast cancer cell via regulating miR-320c/CKAP5 axis.
genetics_GWAS	35902629	hsa-mir-144	Depression	3p as a novel target for diagnosis of MDD as well as for antidepressant treatment, and enhance our understanding of epigenetic processes associated with depression.
lncRNA target	35902548	hsa-mir-766	Spinal Cord Injuries	LncRNA RMRP may contribute to the pathogenesis of SCI via regulating miR
circulation_biomarker_diagnosis_up	35902459	hsa-mir-6089	Ischemic Stroke	In patients with asymptomatic intracranial artery stenosis, downregulated serum hsa-miR-6089 may be associated with the risk of ischemic stroke.
other	35902459	hsa-mir-1225	Ischemic Stroke	Hsa-miR5p, with a large fold change value and a reported relationship with cardiovascular or cerebrovascular diseases, was also validated.
genetics_knock down_promote	35901982	hsa-mir-217	Leukemia, Myeloid, Acute	Furthermore, miR-217 overexpression suppressed cell viability and cell cycle and facilitated apoptosis in rapamycin-exposed AML cells, which were abolished by increasing ATP1B1.
transcription factor target	35901958	hsa-mir-126	Breast Neoplasms	Moreover, the group in vivo treated with targeted OMV(tRNA-pre-miR-126) obviously inhibited the expression of target oncogenic CXCR4, and significantly restrain the proliferation of breast cancer tissues.
lncRNA target	35901619	hsa-mir-142	Endometriosis	Thus, this research sought to survey the impact of MALAT1 on endometrial stromal cell (ESC) proliferation, apoptosis, and inflammation via miR
other	35901329	hsa-mir-24-2	Breast Neoplasms	5p) were identified as potential biomarkers for patients with locally advanced breast cancer.
other	35901329	hsa-mir-664b	Breast Neoplasms	5p) were identified as potential biomarkers for patients with locally advanced breast cancer.
other	35901329	hsa-mir-192	Breast Neoplasms	5p) were identified as potential biomarkers for patients with locally advanced breast cancer.
other	35901329	hsa-mir-609	Breast Neoplasms	5p) were identified as potential biomarkers for patients with locally advanced breast cancer.
other	35901327	hsa-mir-145	Cholangiocarcinoma	3p expression level was observed in patients with perihilar CCA compared to those with distal CCA (0.51  0.41; 0.17  0.13; P = 0.0698).
other	35901327	hsa-mir-101	Cholangiocarcinoma	3p Expression in Patients with INTRODUCTION: Cholangiocarcinoma (CCA) is the second most common type of primary liver cancer.
genetics_GWAS	35900839	hsa-mir-3156	Multiple Endocrine Neoplasia Type 1	5p downregulation is a consequence of loss of MEN1 expression.
lncRNA target	35900705	hsa-mir-5194	Squamous Cell Carcinoma of Head and Neck	Collectively, our study identified an oncogenic role of circPARD3 in HNSCC through a novel machinery of circPARD3/miR-5194/ENO1 and provided a promising therapeutic target for HNSCC.
circRNA target	35900666	hsa-mir-223	Heart Failure	We confirmed that circSnap47 silencing inhibited HF progression via regulation of miR-223/MAPK axis, which will provide for a new therapeutic direction for the treatment of HF.
genetics_overexpression_promote	35900445	hsa-mir-125a	Optic Neuritis	Overexpression of miR-125a-5p suppressed inflammation of the optic nerve, protected retinal ganglion cells, and increased the percentage of Treg cells.
genetics_overexpression_promote	35900059	hsa-mir-874	Colorectal Neoplasms	3p, and overexpression of CCND1 was able to restore the malignant effects of 5-FU-resistant CRC cells that were repressed by miR
transcription factor target	35900049	hsa-mir-128	Inflammation	Moreover, miR3p inhibited HG-induced fibrosis and inflammation in PMCs by targeting PAK2.
lncRNA target	35900049	hsa-mir-128	Fibrosis	3p inhibited HG-induced PMCs fibrosis via PAK2/SyK/TGF-beta1 axis.
other	35900049	hsa-mir-128	Fibrous Dysplasia, Polyostotic	AIM: To elucidate the mechanism of miR3p in peritoneal fibrosis (PF).
other	35900049	hsa-mir-128	Peritoneal Fibrosis	AIM: To elucidate the mechanism of miR3p in peritoneal fibrosis (PF).
transcription factor target	35899982	hsa-mir-4443	Pre-Eclampsia	The present study investigated whether miR-4443 was significantly increased in the placentas of severe preeclamptic patients, and the upregulation of miR-4443 inhibited the migration and invasion of HTR-8/SVneo cells according to transwell assays. This inhibition might further affect the progression of preeclampsia through the HB-EGF/EGFR pathway, thus providing a new clue on the role of miR-4443 in the pathogenesis of preeclampsia.
other	35899951	hsa-mir-502	Carcinoma, Hepatocellular	5p) and cyclin D1 (CCND1) expressions in HCC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRTPCR).
genetics_knock down_promote	35899856	hsa-mir-29b	Osteosarcoma	MiR-29b-3p could directly act on LOXL2 and knockdown of LOXL2 restrained the proliferation, migration, and invasion of OS cells.
genetics_knock down_suppress	35899235	hsa-mir-320d	Chordoma	Moreover, miR-320d overexpression inhibited the proliferation, migration, invasion, and glycolysis of chordoma cells. CONCLUSION: XIST knockdown inhibited chordoma progression via regulating the miR-320d/ARF6 axis, providing a novel insight into chordoma pathogenesis.
lncRNA target	35899199	hsa-mir-15a	pancreatic adenocarcinoma	Based on a series of in silico analyses for reverse prediction of target genes associated with the prognosis of PAAD, a ceRNA network of mRNA (COL1A2, ITGA2, LAMA3, LAMB3, and LAMC2)-microRNA (miR-15a-5p)-long non-coding RNA (LINC00511, LINC01578, PVT1, and TNFRSF14-AS1) was constructed.
circulation_biomarker_diagnosis_ns	35898875	hsa-mir-92b	Melanoma	5p were also enriched in EVs derived from serum of melanoma patients.
circulation_biomarker_diagnosis_ns	35898875	hsa-mir-183	Melanoma	5p were also enriched in EVs derived from serum of melanoma patients.
circulation_biomarker_diagnosis_ns	35898875	hsa-mir-182	Melanoma	5p were also enriched in EVs derived from serum of melanoma patients.
lncRNA target	35898479	hsa-mir-124	Femur Head Necrosis	3p/TGFBR3 axis is supposed to be a latent therapeutic molecular target for GC-induced ONFH.
other	35898472	hsa-let-7c	Lung Neoplasms	The expression level of let-7c-5p and miR-181b-5p may show great significance for the early diagnosis of lung cancer.
other	35898472	hsa-mir-181b	Lung Neoplasms	The expression level of let-7c-5p and miR-181b-5p may show great significance for the early diagnosis of lung cancer.
target gene	35897733	hsa-mir-205	Embryo Loss	miR-205 may inhibit its expression by combining 3'-untranslated regions (3' UTR) of tubulointerstitial nephritis antigen-like 1 (TINAGL1).
other	35897722	hsa-let-7f	Dyslipidemias	We propose a three-miRNA predictive fingerprint (let-7f, miR-376a-3p and miR-376c-3p) and several clinical variables (non-HDLc and years of dyslipidemia) for SI discrimination; this model achieves sensitivity, specificity and area under the receiver operating characteristic curve (AUC) of 83.67%, 88.57 and 89.10, respectively.
other	35897722	hsa-mir-376a	Dyslipidemias	We propose a three-miRNA predictive fingerprint (let-7f, miR-376a-3p and miR-376c-3p) and several clinical variables (non-HDLc and years of dyslipidemia) for SI discrimination; this model achieves sensitivity, specificity and area under the receiver operating characteristic curve (AUC) of 83.67%, 88.57 and 89.10, respectively.
other	35897722	hsa-mir-376c	Dyslipidemias	We propose a three-miRNA predictive fingerprint (let-7f, miR-376a-3p and miR-376c-3p) and several clinical variables (non-HDLc and years of dyslipidemia) for SI discrimination; this model achieves sensitivity, specificity and area under the receiver operating characteristic curve (AUC) of 83.67%, 88.57 and 89.10, respectively.
lncRNA target	35897675	hsa-mir-489	Breast Neoplasms	Overall, our study unveiled the underlying molecular mechanism by which miR-489 regulates an estrogen signaling pathway through a negative feedback loop and uncovered its role in both the development of and overcoming of tamoxifen resistance in breast cancers.
other	35897048	hsa-mir-212	Carcinoma, Endometrioid	CONCLUSION: circWDR26 promoted EC progression by regulating miR3p/MSH2 axis and provided novel insights into anti-cancer treatment.
genetics_overexpression_promote	35896973	hsa-mir-532	Triple Negative Breast Neoplasms	Moreover, in TNBC cell, overexpressing ACTA2-AS1 was found to suppress cell proliferation and metastasis, which was reversed by the upregulation of miR
lncRNA target	35896532	hsa-mir-145	COVID-19	By using human respiratory epithelial cell lines, primary cultured human airway epithelial cells, and murine models of viral structural protein stimulation and SARS-CoV-2 direct challenge, we demonstrated that SARS-CoV-2 nucleocapsid (N) protein could interact with Smad3, which downregulated cystic fibrosis transmembrane conductance regulator (CFTR) expression via microRNA-145.
other	35896371	hsa-mir-409	Carcinoma, Non-Small-Cell Lung	3p/AQP4 axis.
lncRNA target	35896012	hsa-mir-497	Pancreatic Carcinoma	Moreover, we revealed that nuclear factor kappa B 1 (NFB1) was prominently upregulated in pancreatic cancer tissues and pancreatic CSCs, and NFB1 was also identified as a direct target of miR-497.
other	35895593	hsa-mir-21	Uterine Cervical Neoplasms	In addition, the upregulation of microRNA-21 could predict a worse outcome in terms of prognosis in cervical cancer patients.
lncRNA target	35895184	hsa-mir-513a	Uterine Cervical Neoplasms	Furthermore, the dual-luciferase reporter gene system and RNA pulldown assay validated that LINC01287 positively regulated SERP1 expressions by sponging miR-513a-5p, and LINC01287 inhibited cervical cancer progression by regulating miR-513a-5p/SERP1 axis. In conclusion, the current study first identified that LINC01287/miR-513a-5p/SERP1 axis played an important role in cervical cancer progression.
exosome	35894553	hsa-mir-1246	Lung Neoplasms	Additionally, inhibition of miR-1246 attenuated the stemness of lung cancer cells induced by exosomes from cisplatin-resistant cells and spheres.
circulation_biomarker_prognosis_ns	35894480	hsa-mir-138	Diabetes, Gestational	CONCLUSIONS: Circulating Lnc-UCA1/miR-138 axis might be involved in the pathogenesis of GDM and could function as a novel and effective biomarker for GDM risk and neonatal prognosis.
genetics_knock down_promote	35894463	hsa-mir-140	Nasopharyngeal Carcinoma	5p knockdown or BMP2 overexpression enhanced NPC cell proliferation and inhibited apoptosis, thus restoring NPC cell malignant behaviors inhibited by silencing CTBP1-AS2.
circRNA target	35894462	hsa-mir-30	Pancreatic Carcinoma	CONCLUSION: In PC, circ_0008768 can act as a tumor-suppressive factor to inhibit the development of PC by regulating the miR
circRNA target	35894157	hsa-mir-133a	Osteoarthritis	In conclusion, circ-NCX1 may serve as an important regulator of LPS-induced chondrocyte apoptosis through the miR-133a/Sirt1 axis, and may be involved in the development of OA.
other	35894132	hsa-mir-652	Esophageal Squamous Cell Carcinoma	Based on wound healing and Cell Counting Kit8 assays in TE1 human esophageal cancer cells, it was identified that representative miRNA miR652 and miR30a alter migration but not proliferation.
exosome	35893704	hsa-mir-192	Carcinoma, Ovarian Epithelial	Conclusion: Exosomal miR-1260a, miR-7977 and miR
exosome	35893704	hsa-mir-1260a	Carcinoma, Ovarian Epithelial	Conclusion: Exosomal miR-1260a, miR-7977 and miR
lncRNA target	35893593	hsa-mir-142	arteriosclerotic cardiovascular disease	The microbial metabolite IPA/miR5p/ABCA1 pathway may represent a promising therapeutic target for ASCVD.
other	35893235	hsa-mir-339	Diabetic Nephropathies	In-silico analyses also underline a relevant role of NEAT1 and hsa-miR5p in mesangial physiology, especially in the context of DKD.
other	35893230	hsa-mir-181	Plaque, Atherosclerotic	5p can be potential markers of the atherosclerosis process.
other	35893230	hsa-mir-143	Plaque, Atherosclerotic	5p can be potential markers of the atherosclerosis process.
target gene	35892859	hsa-mir-148a	Breast Neoplasms	HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance.
other	35892612	hsa-mir-126	Turner Syndrome	5p was linked with a significantly higher aortic stiffness.
lncRNA target	35892591	hsa-mir-1	Carcinoma, Pancreatic Ductal	MiR-31 may represent a promising therapeutic target for altering radiosensitivity in PDAC cells.
lncRNA target	35892230	hsa-mir-582	Carcinoma, Hepatocellular	It also upregulated (FOXC1), through sponging miR
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-494	Rift Valley Fever	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-494	Aggressive Periodontitis	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-145	Aggressive Periodontitis	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-21	Rift Valley Fever	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-145	Rift Valley Fever	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
circulation_biomarker_diagnosis_ns	35892150	hsa-mir-21	Aggressive Periodontitis	5p, and insulin-like growth factor-I (IGF-I) levels in PRP and platelet-poor plasma (PPP) samples with the pregnancy outcomes in RIF patients.
other	35892093	hsa-mir-4726	Nerve Degeneration	The results revealed interactions in the LINC01133-hsa-miR5p-NDUFA9 axis that may eventually help us understand cocaine- and HIV-1 Tat-induced astrocyte dysfunction that may ultimately result in neurodegeneration.
other	35892093	hsa-mir-4726	Acquired Immunodeficiency Syndrome	The results revealed interactions in the LINC01133-hsa-miR5p-NDUFA9 axis that may eventually help us understand cocaine- and HIV-1 Tat-induced astrocyte dysfunction that may ultimately result in neurodegeneration.
lncRNA target	35892090	hsa-mir-466	Hyperglycemia	Our study demonstrated the potentially effective approach of miR-200/miR-466 cocktail inhibition to restore vascular integrity and tissue repair in hyperglycemia.
genetics_knock down_promote	35892089	hsa-mir-212	Hypertension, Pulmonary	We found that smooth muscle cell (SMC)-specific knockout of miR
genetics_overexpression_promote	35892080	hsa-mir-212	Nasopharyngeal Carcinoma	5p overexpression inhibited the growth and promoted apoptosis of NPC cells; miR
lncRNA target	35892027	hsa-mir-26a	Carcinoma, Renal Cell	In conclusion, our data demonstrate that DLEU7-AS1 is an oncogene in RCC capable of regulating the growth and metastasis of RCC by silencing the miR-26a-5p/coronin-3 axis, suggesting that DLEU7-AS1 can be employed as a potential therapeutic target and prognostic biomarker for RCC.
circRNA target	35891968	hsa-mir-6775	Thyroid Cancer, Papillary	In PTMC tissue samples, compared with the metastasis group, the expression of hsa_circRNA_000121, hsa_circRNA_004183, SRC, and MMP-14 in the nonmetastasis group decreased, while the expression of hsa-miR-4763 and hsa-miR-6775 increased. Hsa_circRNA_000121 may upregulate SRC expression through hsa-miR-4763, while hsa_circRNA 000121 may upregulate MMP-14 expression through hsa-miR-6775, thereby promoting the aggressiveness of PTMC and ultimately leading to cervical lymph node metastasis.
circRNA target	35891968	hsa-mir-4763	Thyroid Cancer, Papillary	In PTMC tissue samples, compared with the metastasis group, the expression of hsa_circRNA_000121, hsa_circRNA_004183, SRC, and MMP-14 in the nonmetastasis group decreased, while the expression of hsa-miR-4763 and hsa-miR-6775 increased. Hsa_circRNA_000121 may upregulate SRC expression through hsa-miR-4763, while hsa_circRNA 000121 may upregulate MMP-14 expression through hsa-miR-6775, thereby promoting the aggressiveness of PTMC and ultimately leading to cervical lymph node metastasis.
lncRNA target	35891783	hsa-mir-4469	Colorectal Neoplasms	METHODS: In this study, we analyzed the miRNA expression profile of colorectal cancer (CRC), constructed a negative regulatory network of the miRNA-target genes, and identified miR-4469 as one of the key tumor suppressors miRNAs.
genetics_overexpression_promote	35891711	hsa-mir-30	ankylosing spondylitis 1	CONCLUSION: Circ_0018168 overexpression restrained fibroblast proliferation and osteogenic differentiation in AS by elevating DKK1 through adsorbing miR
genetics_overexpression_promote	35891465	hsa-mir-150	Porcine Reproductive and Respiratory Syndrome	Subsequently, we demonstrated that PRRSV induced the expression of miR-150 via activating the protein kinase C (PKC)/c-Jun amino-terminal kinases (JNK)/c-Jun pathway, and overexpression of miR-150 suppressed PRRSV replication.
circulation_biomarker_diagnosis_ns	35891387	hsa-mir-29b-1	Vitreoretinochoroidopathy	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2. The inhibition of AdV-C5 infection with miR-29b-1* mimic depended on the IFN-alpha receptor 2 (IFNAR2) and the RNA-helicase retinoic acid-inducible gene I (RIG-I) but not cytoplasmic RNA sensors MDA5 and ZNFX1 or MyD88/TRIF adaptors.
circulation_biomarker_diagnosis_ns	35891387	hsa-mir-29b	Vitreoretinochoroidopathy	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2. The inhibition of AdV-C5 infection with miR-29b-1* mimic depended on the IFN-alpha receptor 2 (IFNAR2) and the RNA-helicase retinoic acid-inducible gene I (RIG-I) but not cytoplasmic RNA sensors MDA5 and ZNFX1 or MyD88/TRIF adaptors.
other	35891387	hsa-mir-29b-1	Severe Acute Respiratory Syndrome	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2.
other	35891387	hsa-mir-29b-1	Influenza, Human	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2.
other	35891387	hsa-mir-29b	Severe Acute Respiratory Syndrome	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2.
other	35891387	hsa-mir-29b	Influenza, Human	Here we discovered that the transfection of human airway cell lines or non-transformed fibroblasts with 24mer dsRNA mimicking the cellular micro-RNA (miR)29b-1* gives strong anti-viral effects against human adenovirus type 5 (AdV-C5), influenza A virus X31 (H3N2), and SARS-CoV-2.
transcription factor target	35890169	hsa-mir-106a	Heart Failure	Here, we show that miRNA106a targets genes that, when misregulated, have been shown to cause hypertrophy and eventual HF. The addition of miRNA106a suppresses misexpressed HF genes and reverses hypertrophy.
lncRNA target	35890132	hsa-mir-181a	Oral Submucous Fibrosis	This study demonstrated that MEG3 exerts a profibrotic effect on OSF by targeting miR-181a/Egr1.
other	35890131	hsa-mir-17	Heart Failure, Acute	The biochemical analysis revealed that the ischemic liver injury following AHF significantly elevated the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) enzymes, the level of total and direct bilirubin, and the expression of hepatic mitogen-activated protein kinase (MAPK), dynaminlike protein (DNM1L), and hepatic miRNA-17.
other	35890121	hsa-mir-29c	Diabetic Cardiomyopathies	Our results elucidate a novel protective mechanism of melatonin on diabetic cardiomyocyte apoptosis, which involved the regulation of lncRNA H19/miR-29c and MAPK pathways, providing a promising strategy for preventing DCM in diabetic patients.
other	35887682	hsa-mir-146a	Acute Coronary Syndrome	Therefore, we explored whether ACS at an early age is a thromboinflammatory disease by analyzing NETs and rs2431697 of miR-146a (a miRNA considered as a brake of TLR/NF-kB pathway), elements previously related to higher rates of recurrence in atrial fibrillation and sepsis.
other	35887682	hsa-mir-146a	Myocardial Infarction	Therefore, we explored whether ACS at an early age is a thromboinflammatory disease by analyzing NETs and rs2431697 of miR-146a (a miRNA considered as a brake of TLR/NF-kB pathway), elements previously related to higher rates of recurrence in atrial fibrillation and sepsis.
other	35887651	hsa-mir-614	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-146a	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-548f-1	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-3170	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-4687	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-4758	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-616	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-934	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
other	35887651	hsa-mir-138-2	Endometrial Neoplasms	Survival analysis showed that high expression of hsa-mir2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients.
lncRNA target	35887339	hsa-mir-143	Alzheimer Disease	3p might play critical roles in regulating both aberrant tau phosphorylation and amyloidogenic processing of APP by targeting DAPK1 and thus offer a potential novel therapeutic strategy for AD.
other	35887269	hsa-mir-126	Arthritis, Rheumatoid	In OA patients, correlations between miR-126 and HIF1 expression and between miR-146 and RORc have been noted.
other	35887269	hsa-mir-26	Arthritis, Rheumatoid	miR-326 was significantly upregulated in RA patients with rheumatoid factor presence.
other	35887269	hsa-mir-146	Arthritis, Rheumatoid	In OA patients, correlations between miR-126 and HIF1 expression and between miR-146 and RORc have been noted.
other	35887223	hsa-mir-222	Prostatic Neoplasms	miR-221 is related to the PC-3 growth rate and MIR222HG is a known risk factor for glioma susceptibility.
other	35887223	hsa-mir-221	Prostatic Neoplasms	miR-221 is related to the PC-3 growth rate and MIR222HG is a known risk factor for glioma susceptibility.
other	35887096	hsa-mir-449	Ciliary Motility Disorders	Altogether, our study establishes a link between miR449, ciliary dysfunction, and COPD pathogenesis.
other	35887096	hsa-mir-449	Pulmonary Disease, Chronic Obstructive	Using transcriptome analysis in COPD-derived bronchial biopsies, we observed a positive correlation between cilia-related genes and microRNA-449 (miR449). Altogether, our study establishes a link between miR449, ciliary dysfunction, and COPD pathogenesis.
other	35887024	hsa-mir-379	Cushing Syndrome	MiR5p was found to be upregulated in PBMAH and CD (log2 fold change > 1.8, p < 0.05).
other	35887024	hsa-mir-1247	Cushing Syndrome	QPCR revealed the upregulated expression of miR5p in CPA and PBMAH (log2 fold change > 2.5, p < 0.05).
transcription factor target	35887021	hsa-mir-34c	Colorectal Neoplasms	We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a.
transcription factor target	35887021	hsa-mir-34a	Colorectal Neoplasms	We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a.
other	35886938	hsa-mir-125a	Deltaretrovirus Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-125a	HTLV-II Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-548d	HTLV-II Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-381	Deltaretrovirus Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-548d	Deltaretrovirus Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-502	Deltaretrovirus Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-502	HTLV-II Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886938	hsa-mir-381	HTLV-II Infections	5p) in both HTLV-2 infected PBMC and BJABGu cell lines.
other	35886863	hsa-mir-133a	Muscular Dystrophy, Duchenne	Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD.
other	35886863	hsa-mir-133b	Muscular Dystrophy, Duchenne	Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD.
other	35886863	hsa-mir-1	Muscular Dystrophy, Duchenne	Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD.
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-1	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-126a	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-378	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-21	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-195	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-206	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
circulation_biomarker_diagnosis_ns	35886860	hsa-mir-34a	Heart Failure	In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR
lncRNA target	35885930	hsa-mir-155	COVID-19	We speculated that microRNA-155 facilitates immune inflammation via targeting SOCS1, thus establishing its association with disease prognosis.
lncRNA target	35885665	hsa-mir-155	Fibrosis	The link between reactive oxygen species (ROS), tumour suppressor p53 (p53), and liver fibrosis-during the pathogenesis of TAA-induced liver injury-associated with miR-155 dysregulation with and without RES incorporation has not been previously studied.
transcription factor target	35885665	hsa-mir-155	Chemical and Drug Induced Liver Injury	The link between reactive oxygen species (ROS), tumour suppressor p53 (p53), and liver fibrosis-during the pathogenesis of TAA-induced liver injury-associated with miR-155 dysregulation with and without RES incorporation has not been previously studied. Liver injuries developed in the model group were confirmed by a significant (p < 0.0001) elevation of hepatic tissue levels of miR-155, ROS, p53, and the profibrogenic biomarkers: tissue inhibitor of metalloproteinases-1 and alpha-smooth muscle actin, as well as collagen deposition (fibrosis).
other	35885665	hsa-mir-155	Liver Diseases	MicroRNAs (miRs), such as miR-155, have been implied in the pathogenesis of liver disease, and regulated by the antioxidant and anti-inflammatory compound resveratrol (RES).
lncRNA target	35885439	hsa-mir-181a	Pre-Eclampsia	Through the performance of the training cohort (0.848 AUC, 0.73-0.96 95% CI, 80% sensitivity, 85% specificity, p < 0.001) and the validation cohort (0.852 AUC, 0.74-0.98 95% CI, 75% sensitivity, 87% specificity, p < 0.001) from one hundred and fifty-two women with a combination of miR-210, miR-181a and BMI, we established a preeclampsia prediction model for the first trimester.
lncRNA target	35885439	hsa-mir-210	Pre-Eclampsia	Through the performance of the training cohort (0.848 AUC, 0.73-0.96 95% CI, 80% sensitivity, 85% specificity, p < 0.001) and the validation cohort (0.852 AUC, 0.74-0.98 95% CI, 75% sensitivity, 87% specificity, p < 0.001) from one hundred and fifty-two women with a combination of miR-210, miR-181a and BMI, we established a preeclampsia prediction model for the first trimester.
transcription factor target	35884996	hsa-mir-506	Pancreatic Carcinoma	In PDAC, miR-506 is mainly considered as a tumor-suppressing miRNA.
transcription factor target	35884935	hsa-mir-375	Spinal Cord Injuries	Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR5p potentially improving neuroplasticity via its regulatory involvement with BDNF.
transcription factor target	35884935	hsa-mir-382	Spinal Cord Injuries	Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR5p potentially improving neuroplasticity via its regulatory involvement with BDNF.
other	35884866	hsa-mir-107	Depression	Additionally, miRNA analysis identified hsa-miR-107 as a possible biological link between APOE epsilon4, depressive symptoms, and cognitive impairment.
genetics_knock down_suppress	35884864	hsa-mir-138	Spinal Cord Injuries	5p downregulation correlates with the overexpression of its pro-apoptotic targets.
other	35884636	hsa-let-7c	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-mir-125b	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-mir-25	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-mir-1469	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-mir-29a	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-let-7f	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-let-7b	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-let-7e	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
other	35884636	hsa-let-7a	Tic Disorders	As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS.
lncRNA target	35884604	hsa-mir-200c	Triple Negative Breast Neoplasms	We demonstrated that NPC1 is directly targeted by microRNA-200c (miR-200c), a potent suppressor of EMT, providing a mechanism for its differential expression in breast cancer subtypes.
genetics_knock down_promote	35884594	hsa-mir-99a	Stomach Neoplasms	After knockdown of HOXC-AS1, miR-99a-3p was clearly overexpressed in GC cells. Finally, rescue experiments for CCK-8 were completed, disclosing that HOXC-AS1 promoted cell progression of GC through sponging miR-99a-3p followed by subsequent upregulation of MMP8.
circulation_biomarker_diagnosis_ns	35884554	hsa-mir-222	Triple Negative Breast Neoplasms	This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs.
circulation_biomarker_diagnosis_ns	35884554	hsa-mir-124	Triple Negative Breast Neoplasms	This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs.
circulation_biomarker_diagnosis_ns	35884554	hsa-mir-21	Triple Negative Breast Neoplasms	This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs.
other	35884524	hsa-mir-1	Pulmonary Fibrosis	Using an in vitro co-culture system, involving directly irradiated skeletal muscle and unirradiated ventricular cardiac human cells, we propose the role of miR-1/133a as mediators of the abscopal response, suggesting that miRNA-based strategies could be relevant for limiting tissue-dependent reactions in non-directly irradiated tissues.
exosome	35884336	hsa-mir-92a	Colorectal Neoplasms	Colorectal cancer (CRC)-associated miR-92a-3p extracted from exosomes was selected as the target.
lncRNA target	35883863	hsa-mir-155	Hypertension	5p/eNOS/NO/IkappaB cycle after the activation of AMPK/UCP2 and the subsequent inhibition of ROS in hypertensive rat renal artery endothelial cells.
lncRNA target	35883863	hsa-mir-155	Vascular Diseases	5p/eNOS/NO/IkappaB cycle after the activation of AMPK/UCP2 and the subsequent inhibition of ROS in hypertensive rat renal artery endothelial cells.
exosome	35883438	hsa-mir-21	Ischemic Stroke	These results suggest that BMSC-Exos could promote angiogenesis via miR
transcription factor target	35883205	hsa-mir-148a	Liver Cirrhosis	5p and inhibiting the Notch signaling pathway.
exosome	35883161	hsa-mir-126	Ovarian Failure, Premature 	3p promote angiogenesis and attenuate OGCs apoptosis in POF, which highlighted the potential of exosomes containing miR
transcription factor target	35883156	hsa-mir-152	Osteoporosis	5p is the first identified to regulate osteogenic differentiation by directly targeting autophagy-related protein ATG14 and regulating oxidative stress and therapeutic inhibition of miR
genetics_overexpression_promote	35883151	hsa-mir-17	Aortic Aneurysm, Abdominal	Furthermore, overexpression of miR
circulation_biomarker_diagnosis_ns	35882857	hsa-mir-670	Kidney Failure, Chronic	Elevated levels of plasma exosomal miR
circRNA target	35882184	hsa-mir-182	Rhinitis, Allergic	Furthermore, hsa_circRNA_404013 may regulate the expression level of BDNF through hsa-mir
genetics_overexpression_suppress	35882167	hsa-mir-498	Stomach Neoplasms	The stimulation of GC cell proliferation, migration, and EMT, which had been engendered by CEACAM5 overexpression, was reversible through the overexpression of miR-498.
other	35881155	hsa-mir-107	Alzheimer Disease	Circ_0049472 modulated KIF1B by serving as a miR-107 decoy, thereby mediating Abeta-induced neurotoxicity, suggesting that circ_0049472 may be involved in AD pathogenesis.
other	35881147	hsa-mir-222	Alcoholism	miR3p has been reported to play a key role in various neurological diseases and is strongly associated with alcohol dependence.
other	35881147	hsa-mir-222	Nervous System Diseases	miR3p has been reported to play a key role in various neurological diseases and is strongly associated with alcohol dependence.
genetics_GWAS	35881147	hsa-mir-222	Cataract, posterior polar, 3	Following adeno-associated virus (AAV)-mediated overexpression or knockdown of miR
other	35880950	hsa-mir-421	Reperfusion Injury, Cerebral Ischemia	Collectively, the regulation of lncRNA ZFAS1/miR3p/MEF2C axis showed protective effects on cerebral ischemia-reperfusion injury.
other	35880624	hsa-mir-185	Norrie disease	Taken together, our data suggested that circ_0114428 might promote DN progression by regulating the miR5p/SMAD3 axis.
other	35880619	hsa-mir-223	Pneumonia, Mycoplasma	CONCLUSIONS: All results manifested that circ_0005714 retarded the progression of PE by mediating the miR3p/ADAM9 signal network.
lncRNA target	35880572	hsa-mir-217	Pulmonary Disease, Chronic Obstructive	Collectively, these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR5p/PTEN axis, which may help develop novel therapeutic strategies against COPD.
lncRNA target	35880572	hsa-mir-217	Pneumonia	Collectively, these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR5p/PTEN axis, which may help develop novel therapeutic strategies against COPD.
circulation_biomarker_prognosis_up	35880500	hsa-mir-133b	Muscular Dystrophy, Duchenne	We found a significant upregulation of serum miR-1, miR-133a, miR-133b and miR-206 in our cohort of BMD patients, supporting the role of these miRNAs in the pathophysiology of the disease, and we identified serum cut-off levels discriminating patients from healthy controls, confiming the potential of circulating miRNAs as promising noninvasive biomarkers. Moreover, serum levels of miR-133b were found to be associated with fibrosis at muscle biopsy and with patients' motor performances, suggesting that miR-133b might be a useful prognostic marker for BMD patients.
circulation_biomarker_diagnosis_ns	35880306	hsa-mir-647	Atherosclerosis	Moreover, the expression of miR-647 increased in ox-LDL-treated vascular smooth muscle cells and peripheral blood of patients with coronary heart disease.
other	35880174	hsa-mir-548k	Pre-Eclampsia	Based on the transcriptome level of key genes, we proposed that RELA-miR-548K/miRTPBG may be a potential RNA regulatory pathway regulating the progression of early preeclampsia.
other	35880174	hsa-mir-1206	Pre-Eclampsia	Based on the transcriptome level of key genes, we proposed that RELA-miR-548K/miRTPBG may be a potential RNA regulatory pathway regulating the progression of early preeclampsia.
circulation_biomarker_prognosis_ns	35880009	hsa-mir-487b	Vitiligo	ROC curve analysis (area under curve = 0.840) indicated that hsa-miR-487b-3p could serve as a biomarker for the prognosis of vitiligo progression. CONCLUSION: Serum exosomal hsa-miR-487b-3p can be a biomarker to detect vitiligo progression.
circulation_biomarker_diagnosis_ns	35879917	hsa-mir-34a	Reperfusion Injury, Hepatic Ischemia	We constructed a rat HIRI model and treated it with an intraperitoneal injection of agomir-miR-34a-5p or agomir-normal control (NC) for 7 days after the surgery. HIRI+agomir-miR-34a-5p rats exhibited significantly higher miR-34a-5p expression, lower serum alanine aminotransferase, aspartate aminotransferase, alleviated hepatic necrosis, reduced hepa- tocyte apoptosis, and decreased expression of apoptosis-related proteins, when compared with HIRI+agomir-NC rats (P < .05).
circulation_biomarker_diagnosis_up	35879811	hsa-mir-204	Diabetic Foot	3p in peripheral blood and wound tissue of T2DM patients is closely related to the occurrence and poor wound healing of DFU.
transcription factor target	35879698	hsa-mir-29a	Adenocarcinoma of Lung	Subsequent experiments showed that miR-29a-3p could decrease the cell mobility and proliferation positive cell rates, as well as reduce the migratory and invasive possibilities in LUAD cells via downregulating C1QTNF6. CONCLUSION: Our study first demonstrated that downregulation of C1QTNF6 could inhibit tumorigenesis and progression in LUAD cells negatively regulated by miR-29a-3p.
circulation_biomarker_diagnosis_ns	35879425	hsa-mir-127	Osteoarthritis	We validated the assay to detect circulating miR5p in synovial fluid, recently indicated as a predictive biomarker for osteoarthritis disease.
lncRNA target	35878746	hsa-mir-143	Intervertebral Disc Degeneration	3p inhibits the transcriptional activity of SOX5 through targeted binding, thereby inducing intervertebral disc degeneration.
transcription factor target	35878435	hsa-mir-132	Temporomandibular Joint Osteoarthritis	3p and PTEN in TMJOA was verified, and rescue experiments were conducted via co-upregulation of the expression of both miR
transcription factor target	35877720	hsa-mir-193a	Drug Hypersensitivity	At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR
transcription factor target	35877720	hsa-mir-16	Drug Hypersensitivity	At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR
transcription factor target	35877720	hsa-mir-214	Drug Hypersensitivity	At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR
transcription factor target	35876890	hsa-mir-33a	Carcinoma, Non-Small-Cell Lung	We defined a signature of 13 miRNAs that strongly correlate with APE1 expression in human lung cancer: miR-1246, miR-4488, miR-24, miR-183, miR-660, miR-130b, miR-543, miR-200c, miR-376c, miR-218, miR-146a, miR-92b and miR-33a. Our findings, suggesting that APE1 modulates DICER1 expression via miR-33a and miR-130b, reveal new mechanistic insights on DICER1 regulation, which are of relevance in lung cancer chemoresistance and cancer invasiveness.
transcription factor target	35876890	hsa-mir-130b	Carcinoma, Non-Small-Cell Lung	We defined a signature of 13 miRNAs that strongly correlate with APE1 expression in human lung cancer: miR-1246, miR-4488, miR-24, miR-183, miR-660, miR-130b, miR-543, miR-200c, miR-376c, miR-218, miR-146a, miR-92b and miR-33a. Our findings, suggesting that APE1 modulates DICER1 expression via miR-33a and miR-130b, reveal new mechanistic insights on DICER1 regulation, which are of relevance in lung cancer chemoresistance and cancer invasiveness.
genetics_knock down_promote	35876480	hsa-mir-7	Keloid	Circ_0057452 knockdown suppressed keloid development by regulating miR
other	35876391	hsa-mir-145	Breast Neoplasms	For patients with luminal breast cancers, reduced Let-7a predicted achieving a pCR ( P =0.037) and reduced miR-145 predicted achieving a pCR to NAC in HER2+ ( P =0.027).
other	35876391	hsa-let-7a	Breast Neoplasms	For patients with luminal breast cancers, reduced Let-7a predicted achieving a pCR ( P =0.037) and reduced miR-145 predicted achieving a pCR to NAC in HER2+ ( P =0.027).
circulation_biomarker_diagnosis_ns	35876212	hsa-mir-8485	Heart Failure	It was found that miR-8485 level was markedly reduced in the plasma of CHF patients, compared with the healthy controls.
lncRNA target	35876160	hsa-mir-377	Endometrial Neoplasms	CONCLUSION: BBR was found to inhibit EC via the circ_ZNF608/miR3p/COX2 axis, which is helpful in endometrial carcinoma.
circulation_biomarker_diagnosis_ns	35876150	hsa-mir-607	Diabetes Mellitus, Type 2	The levels of lncRNA TUG1, hsa-miR-607 and hsa_circ_0071106 in peripheral blood have potential clinical diagnostic value for T2DM.
other	35876135	hsa-mir-96	Endometriosis	CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis.
other	35876135	hsa-mir-182	Endometriosis	CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis.
other	35876135	hsa-mir-183	Endometriosis	CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis.
circulation_biomarker_diagnosis_ns	35875355	hsa-mir-22	familial temporal lobe epilepsy 3	Moreover, the high area under the ROC curve (0.777; 95% CI 0.629-0.925; p = 0.001) suggests that low miR-22 serum levels may be a sensitive predictor of poor response to AEDs among MTLE-HS patients.
other	35875068	hsa-mir-34a	Colorectal Neoplasms	5p/ZG16, and hsa-miRNA 3064-5p/SH3BGRL3, were identified in samples of adenoma, IMC, and CRC with the MSS phenotype.
other	35875068	hsa-mir-22	Colorectal Neoplasms	In adenomatous lesions obtained from the same tumor with a carcinomatous lesion, we identified pairs of miRNA-130a-3p/HSPA8 and miRNA3p/RP53 that were linked to multiple pathways.
other	35875068	hsa-mir-130a	Colorectal Neoplasms	In adenomatous lesions obtained from the same tumor with a carcinomatous lesion, we identified pairs of miRNA-130a-3p/HSPA8 and miRNA3p/RP53 that were linked to multiple pathways.
other	35875068	hsa-mir-660	Colorectal Neoplasms	On the other hand, 2 pairs of miRNA/mRNA (miRNA5p and miRNA-664a-5p/APP) were found in isolated carcinomatous glands.
other	35875068	hsa-mir-664a	Colorectal Neoplasms	On the other hand, 2 pairs of miRNA/mRNA (miRNA5p and miRNA-664a-5p/APP) were found in isolated carcinomatous glands.
circulation_biomarker_prognosis_up	35874900	hsa-mir-106	Atrial Fibrillation	With the increase of the severity of atrial fibrillation, the level of serum miR-106 gradually increased and the level of MYL4 gradually decreased, which were statistically significant compared with the control group (P < 0.05).
transcription factor target	35874899	hsa-mir-22	Melanoma	This work was to investigate mechanism by which mir-22 targeting nod-like receptor protein 3 (NLRP3) inflammasome affected activity of human skin malignant melanoma (MM) A375 cells. Therefore, miR-22 may target and inhibit the activation of the NLRP3 inflammasome to reduce the activity of cutaneous malignant melanoma A375 cells.
circRNA target	35874898	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The current study revealed that circ_0000518 may have a prooncogenic function in the formation and progression of NSCLC, which might be achieved through moderating the miR3p/SLC1A5 axis.
lncRNA target	35874804	hsa-mir-622	Intervertebral Disc Degeneration	These data suggested that circ_0005918 played important roles in the development of IDD via sponging miR-622.
transcription factor target	35874782	hsa-mir-100	Dacryocystitis	CONCLUSION: Our data indicated that hUC-MSC-sEVs alleviated autoimmune dacryoadenitis by promoting M2 macrophage polarization and Treg generation possibly through shuttling miR5p.
target gene	35874630	hsa-mir-296	Colorectal Neoplasms	Long Noncoding XLOC_006390 Regulates the Proliferation and Metastasis of Human Colorectal Cancer via miR-296/ONECUT2 Axis.
other	35873767	hsa-mir-133b	Muscular Dystrophy, Duchenne	In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment.
other	35873767	hsa-mir-208b	Muscular Dystrophy, Duchenne	In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment.
other	35873767	hsa-mir-499	Muscular Dystrophy, Duchenne	In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment.
other	35873767	hsa-mir-133a	Muscular Dystrophy, Duchenne	In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment.
other	35873767	hsa-mir-1	Muscular Dystrophy, Duchenne	In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment.
genetics_overexpression_promote	35873641	hsa-mir-199	Cardiotoxicity	In this study, overexpression of miR-199 could promote cardiotoxicity.
genetics_overexpression_promote	35873635	hsa-mir-28	Lymphoma, Large B-Cell, Diffuse	The overexpression of hsa-miR
other	35873535	hsa-mir-21	Corneal Injuries	CONCLUSION: HUMSC-sEVs could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21 and may represent a promising novel therapeutic agent for corneal wound repair.
other	35873535	hsa-mir-21	Corneal Ulcer	CONCLUSION: HUMSC-sEVs could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21 and may represent a promising novel therapeutic agent for corneal wound repair.
other	35873473	hsa-mir-101	Urinary Bladder Neoplasms	NEAT1/MALAT1/XIST/PKD--Hsa-Mir3p--DLGAP5 Axis as a Novel Diagnostic and Background: The clinical value of the biomarkers of bladder cancer (BC) is limited due to their low sensitivity or specificity.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-23b	Acute-On-Chronic Liver Failure	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-339	Hepatitis B, Chronic	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-23b	Hepatitis B, Chronic	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-223	Acute-On-Chronic Liver Failure	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-339	Acute-On-Chronic Liver Failure	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
circulation_biomarker_diagnosis_ns	35873157	hsa-mir-223	Hepatitis B, Chronic	5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF.
genetics_overexpression_suppress	35873150	hsa-let-7	Influenza, Human	We found that influenza A virus (IAV) infection caused a significant decrease of microRNA let-7 expression in host cells; that overexpression of let-7 increased interferon expression and effectively inhibit IAV infection; and that let-7 targets the 3'-untranslated region (UTR) of the ribosomal protein 16 (RPS16) gene, decreasing its expression.
other	35873003	hsa-mir-15a	Obesity	Using an in vivo reductionist approach and POMC(Cre)-dependent CRISPR-Cas9, we demonstrate that miR-15a-5p protects from obesity.
other	35872948	hsa-mir-424	Neurotoxicity Syndromes	After exposure to ISO, induced neurotoxicity and a decreased miR5p production were identified in hESC-derived neurons.
other	35872948	hsa-mir-424	Nerve Degeneration	Although miR5p is considerably downregulated in ISO-treated rat brain samples, its physiological role in ISO-induced neuronal injury in human embryonic stem cell-derived neurons remains unknown (hESC-derived neurons).
lncRNA target	35872931	hsa-mir-760	Lung Neoplasms	The miR-760 and IDO1 levels in NSCLC were tested via real-time quantitative polymerase chain reaction (qRT-PCR) and western blotting (WB).
other	35872885	hsa-mir-223	Acute Coronary Syndrome 	An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS.
other	35872885	hsa-mir-125a	Acute Coronary Syndrome	An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS.
other	35872885	hsa-mir-223	Acute Coronary Syndrome	An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS.
other	35872885	hsa-mir-125b	Acute Coronary Syndrome	CONCLUSION: In this hypothesis generating study, lower values of miR-125b were related to improved long-term survival in patients with ACS and MVD.
other	35872885	hsa-mir-125b	Acute Coronary Syndrome 	CONCLUSION: In this hypothesis generating study, lower values of miR-125b were related to improved long-term survival in patients with ACS and MVD.
other	35872885	hsa-mir-125a	Acute Coronary Syndrome 	An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS.
lncRNA target	35872873	hsa-mir-29a	Keloid	CONCLUSION: The miRNA-mRNA network, especially miR-29a-3p and its targets, may provide insights into the underlying pathogenesis of keloid and serve as potential biomarkers for keloid treatment.
lncRNA target	35872698	hsa-mir-339	Glioma	5p inhibitory functions in glioma through PTP4A1/HMGB1 pathway.
transcription factor target	35872695	hsa-mir-622	Stomach Neoplasms	CONCLUSION: miR-622 and NUAK1 demonstrated potential for being targets and biomarkers for GC treatment.
lncRNA target	35872625	hsa-mir-588	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ_0010235 contributed to the malignant progression of NSCLC, but suppressed the radiation sensitivity via targeting miR- 588 to induce HOXA10 upregulation.
other	35872368	hsa-mir-433	Colorectal Neoplasms	CONCLUSION: We first revealed PCGEM1/miR3p/CTCF positive feedback loop as an oncogenic axis in CRC cells, which potentially provides new clues for the advancement of CRC treatment.
tissue_expression_up	35872110	hsa-mir-9	Ataxia Neuropathy Spectrum	These results showed that miR9-3 deficiency initiated the damage to the entire hematopoietic system.
tissue_expression_ns	35872110	hsa-mir-9	immunodeficiency 9	deficiency impaired the development of B cells in BM.
circRNA target	35871508	hsa-mir-106a	Diabetic Nephropathies	CONCLUSION: Our data indicated that circ_0068087 downregulation mitigated HG-induced HK2 cell injury through the miR-106a-5p/ROCK2 axis, providing a potential circRNA-targeted therapy for DN.
other	35871268	hsa-mir-149	Brain Ischemia 	Each group was divided into three subgroups to assess the volume of the tissue damage and neurological deficits scores (NDS) in subgroup 1, brain water content in subgroup 2, level of miRNA5p and CCC expressions in subgroup 3.
exosome	35870977	hsa-mir-106a	Diabetic Foot	Exosomal mmu_circ_0001052 was determined to sponge miR-106a-5p that targeted FGF4 in DFU.
genetics_overexpression_suppress	35869728	hsa-mir-223	Myelodysplastic Syndromes	overexpression of miR-223-3p can effectively inhibit the expression of NLRP3 and cell pyroptosis in MDS.
transcription factor target	35869720	hsa-mir-218	Uterine Cervical Neoplasms	As the second most common gynecological tumor in the world, cervical cancer has always been a female killer.Some studies have shown that miR-218 can inhibit the invasion and migration of cervical cancer cells through two target genes, SFMBT1and DCUNIDI. On this basis, this paper presents the study that miR-218 affects the invasion and migration of cervical cancer cells by inhibiting the expression of target genes, SFMBT1 and DCUNIDI.
genetics_overexpression_promote	35869716	hsa-mir-138	Breast Neoplasms	For this aim, the endometrial stem breast cancer cell line MCF-7 was cultured in vitro, and the overexpression mimic miR-138 mimics and the inhibitor anti-miR-138 were transfected into the endometrial stem breast cancer cell line MCF-7, which was set to overexpress miR-138 group and interfere with miR-138, and set up negative control of overexpression and negative control of inhibitor.
genetics_knock down_promote	35869629	hsa-mir-28	Acute Kidney Injury	Furthermore, we found that PT-METTL3-KO or METTL3 siRNA significantly suppressed ischemic, septic, and vancomycin-induced AKI via downregulation of the mmu-lncRNA 121686/miR
other	35869509	hsa-mir-127	Huntington Disease	Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step.
other	35869509	hsa-mir-212	Huntington Disease	Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step.
other	35869509	hsa-mir-196b	Huntington Disease	Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step.
other	35869509	hsa-mir-132	Huntington Disease	Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step.
other	35869509	hsa-mir-10b	Huntington Disease	Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step.
other	35868429	hsa-mir-29c	Liver Diseases, Alcoholic	miR-29c is differentially expressed in alcoholic liver disease.
other	35868352	hsa-mir-146	Leukemia-Lymphoma, Adult T-Cell	Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients.
other	35868352	hsa-mir-125	Leukemia-Lymphoma, Adult T-Cell	Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients.
other	35868352	hsa-mir-451	Leukemia-Lymphoma, Adult T-Cell	Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients.
other	35868352	hsa-mir-1	Leukemia-Lymphoma, Adult T-Cell	Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients.
lncRNA target	35868335	hsa-mir-148a	Prostatic Neoplasms	Finally, real-time PCR was used to evaluate the regulatory effects of curcumin and paclitaxel on miR-148a and its target genes.
genetics_GWAS	35867864	hsa-mir-221	Kidney Diseases	In CKD 2-3 patients, elevation of FGF23 was associated with increased pulse wave velocity and reduced plasma levels of miR-221/222.
genetics_GWAS	35867864	hsa-mir-221	Juvenile gout	In CKD 2-3 patients, elevation of FGF23 was associated with increased pulse wave velocity and reduced plasma levels of miR-221/222.
genetics_knock down_promote	35867177	hsa-mir-181a	Liver Neoplasms	Its levels were maintained in miR-181 KO liver tumours.
lncRNA target	35866931	hsa-mir-21	Osteoarthritis	In a nutshell, our study reported that the anti-OA effects of Rb1 relied on the inhibited expression of miR
transcription factor target	35866896	hsa-mir-708	Osteomyelitis	A bacteria-sensitive natural polymer hyaluronic-acid-based hydrogel (HA hydrogel) loaded with antagomiR5p exhibited promising effects in an in vivo study through antibacterial and pro-osteogenic differentiation functions in infected fractures.
circRNA target	35866672	hsa-mir-512	Lung Neoplasms	5p inhibited the malignant behaviors of lung cancer cells via downregulating KIAA0100.
other	35866630	hsa-mir-181d	Inflammation	Moreover, the regulatory relationships among circ_0035266, miR-181d-5p, and DDX3X were further confirmed using a group of lung cancer tissues.
lncRNA target	35866606	hsa-mir-335	Aortic Dissection	5p may be a potential therapeutic target in AD.
genetics_knock down_promote	35866595	hsa-mir-34b	Adenocarcinoma of Lung	Our study demonstrated that the regulation of RP11805J14.5 on LUAD was mediated by CCND2 whose expression was regulated by sponging miR34b3p and miR1395p. The expression of RP11805J14.5 was increased in LUAD, and the knockdown of RP11805J14.5 expression suppressed LUAD cell growth, invasion and migration by downregulating CCND2 by sponging miR34b3p and miR1395p, indicating that RP11805J14.5 could be a prospective target for LUAD therapy.
genetics_knock down_promote	35866595	hsa-mir-139	Adenocarcinoma of Lung	Our study demonstrated that the regulation of RP11805J14.5 on LUAD was mediated by CCND2 whose expression was regulated by sponging miR34b3p and miR1395p. The expression of RP11805J14.5 was increased in LUAD, and the knockdown of RP11805J14.5 expression suppressed LUAD cell growth, invasion and migration by downregulating CCND2 by sponging miR34b3p and miR1395p, indicating that RP11805J14.5 could be a prospective target for LUAD therapy.
genetics_overexpression_promote	35866594	hsa-mir-491	Carcinoma, Non-Small-Cell Lung	miR4913p overexpression suppressed the in vivo growth of NSCLC.
lncRNA target	35866591	hsa-mir-4429	Carcinoma, Renal Cell	By intervening microRNA (miR)4492 and UBE2C by the transfection of miR4429mimics or short interfering UBE2C2, the regulatory effect of lncRNA FTX/miR4429/UBE2C axis on the progression of RCC was evaluated. Overall, the present study showed that lncRNA FTX was upregulated in RCC and could significantly promote the proliferative, migratory and invasive capacities, enhancing the viability and accelerating the cell cycle progression of RCC cells by exerting the miRNA sponge effect on miR4429 and thus upregulating UBE2C.
circRNA target	35865464	hsa-mir-27b	Esophageal Squamous Cell Carcinoma	CircLONP2 promotes ESCC aggressiveness by directly interacting with miR-27b-3p, thus upregulating the expression levels of its target gene ZEB1 by suppressing miR-27b-3p activity. Therefore, we demonstrated that circLONP2/miR-27b-3p/ZEB1 axis promotes ESCC metastasis via regulating epithelial-to-mesenchymal transition (EMT)-related proteins.
other	35865405	hsa-mir-34a	Lymphoma, Mantle-Cell	CONCLUSION: Upregulation of circCTNNA1 in MCL predicts poor survival of patients and it may sponge miR-34a to promote cancer cell proliferation.
transcription factor target	35865391	hsa-mir-21	Cardiomyopathies	This study aimed to explore the roles of miR-208b, miR-21 and transforming growth factor-beta1 (TGF-beta1)/Smad-3 signaling pathway components in cardiac fibrosis development. CONCLUSION: MiR-208b and miR-21 promote cardiac fibrosis progression through TGF-beta1/Smad-3 signaling pathway activation.
transcription factor target	35865391	hsa-mir-208b	Cardiomyopathies	This study aimed to explore the roles of miR-208b, miR-21 and transforming growth factor-beta1 (TGF-beta1)/Smad-3 signaling pathway components in cardiac fibrosis development. CONCLUSION: MiR-208b and miR-21 promote cardiac fibrosis progression through TGF-beta1/Smad-3 signaling pathway activation.
transcription factor target	35865382	hsa-mir-21	Heart Failure, Chronic	CONCLUSION: Paeonol shows a cardioprotective effect on DOX-induced CHF via regulating the miR
lncRNA target	35864972	hsa-mir-149	Cholangiocarcinoma	These findings indicated that YY1-induced DLEU1 played a crucial role in CCA progression via miR
other	35864871	hsa-mir-23a	Prostatic Neoplasms	We also verified the SNHG17/miR-23a/OTUB1 axis in RV-1 and PC-3 cells by dual luciferase and RIP assays, and we further identified that SNHG17 promoted cellular invasive capacity by modulating OTUB1.
lncRNA target	35864552	hsa-mir-1	Urinary Bladder Neoplasms	CONCLUSIONS: This study reveals the pro-metastatic and proliferative function of upregulated glycosyltransferase C1GLAT1, and provides preliminary data on mechanisms underlying dysregulation of C1GALT1 via miR
lncRNA target	35864549	hsa-mir-200b	Adenocarcinoma of Lung	CONCLUSIONS: We confirmed that MARCKSL1-2 alleviated DTX resistance in LAD cells by abolishing the inhibitory effect of HDAC1 on miR-200b via the recruitment of SUZ12.
circRNA target	35864511	hsa-mir-1307	Stomach Neoplasms	RESULTS: CircDIDO1 inhibited GC progression by regulating the expression of the signal transducer inhibitor SOSC2 through sponging miR
circulation_biomarker_diagnosis_ns	35864328	hsa-mir-26	Atrial Fibrillation	CONCLUSIONS: RFA helped to restore circulating levels of miR-26, which were reduced in atrial fibrillation.
other	35863536	hsa-mir-24	Growth Hormone-Secreting Pituitary Adenoma	By profile sequencing, we further identified some antioxidant closely related miRNAs shared in the VE and PAP groups, including miR-30, miR-24, miR-19b, and miR-100.
other	35863536	hsa-mir-100	Growth Hormone-Secreting Pituitary Adenoma	By profile sequencing, we further identified some antioxidant closely related miRNAs shared in the VE and PAP groups, including miR-30, miR-24, miR-19b, and miR-100.
genetics_knock down_promote	35863454	hsa-mir-1249	Carcinoma, Non-Small-Cell Lung	CircHIPK2 knockdown or miR
circulation_biomarker_diagnosis_ns	35863239	hsa-mir-223	Cardiovascular Diseases	Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a.
circulation_biomarker_diagnosis_ns	35863239	hsa-mir-183	Cardiovascular Diseases	Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a.
circulation_biomarker_diagnosis_ns	35863239	hsa-mir-378a	Cardiovascular Diseases	Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a.
circulation_biomarker_diagnosis_ns	35863239	hsa-mir-150	Cardiovascular Diseases	Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a.
exosome	35863089	hsa-mir-10a	Leukemia, Myeloid, Acute	Down-regulation of miR-10a substantially increase chemosensitivity of AML cells treated with BMSCs-Exos.
genetics_overexpression_promote	35862727	hsa-mir-27a	Wilms Tumor	In addition, overexpression of PBOV1 antagonized the tumor-suppressive effect of miR-27a-5p in Wilms' tumor cells.
other	35862485	hsa-mir-1343	Bovine Virus Diarrhea-Mucosal Disease	In SER, the CO group had levels of miR3p significantly higher than the CT and MB groups (P = 0.0071).
other	35862468	hsa-mir-335	Hypertension, Pulmonary	mediated downregulation of Vangl2 and thereby promoting the expression of Vangl2 to prevent PH.
genetics_knock down_promote	35862252	hsa-mir-137	Glioblastoma	BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state.
genetics_knock down_promote	35862252	hsa-mir-128	Glioblastoma	BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state.
genetics_knock down_promote	35862252	hsa-mir-124	Glioblastoma	BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state.
other	35862223	hsa-mir-122	Angelman Syndrome	5p, which was related to cardiomyocyte dysfunction.
other	35862223	hsa-mir-26a	Angelman Syndrome	5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement.
other	35862223	hsa-mir-1274	Angelman Syndrome	5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement.
other	35862223	hsa-mir-192	Angelman Syndrome	5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement.
circRNA target	35861841	hsa-mir-340	Pulmonary Arterial Hypertension	5p to aggravate PH progression by promoting TCF4/beta-catenin/TWIST1 complex, which may provide potential therapeutic targets for PH.
genetics_knock down_promote	35861544	hsa-mir-133b	Uterine Cervical Neoplasms	Downregulation of miR-133b partly reversed the DDP sensitivity of circ_0005273 knockdown in DDP-resistant CC cells.
circulation_biomarker_diagnosis_ns	35860808	hsa-mir-1246	Intracranial Aneurysm	PRINCIPLE FINDINGS AND RESULTS: Serum levels of miR-1246 were elevated in intracranial aneurysm patients.
other	35860691	hsa-mir-26a	Carcinoma, Non-Small-Cell Lung	METHODS: The expression of miR-26a-5p in NSCLC cell lines was detected by qPCR and verified in NSCLC tissues from TCGA using Limma R package. RESULTS: The expression of miR-26a-5p was downregulated in the tumor tissues comparted to adjacent normal tissues as well as NSCLC cell lines compared to normal lung epithelial cell (BEAS2B).
lncRNA target	35860558	hsa-mir-6747	Small Cell Lung Carcinoma	lncRNAs (lncRNA-AC005005.4-201 and NEAT1-203) and circRNAs (circRNA-hsa_HLA-B_1 and hsa_VEGFC_8) may regulate the inhibited effects of hsa-miR
lncRNA target	35860558	hsa-mir-4525	Small Cell Lung Carcinoma	lncRNAs (lncRNA-AC005005.4-201 and NEAT1-203) and circRNAs (circRNA-hsa_HLA-B_1 and hsa_VEGFC_8) may regulate the inhibited effects of hsa-miR
tissue_expression_ns	35860182	hsa-mir-495	Sepsis	OBJECTIVE: This study is aimed at evaluating the miR3p and miR3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. ROC curve was performed to evaluate the diagnostic value of miR3p and miR3p for SA-AKI. The prognostic performance of miR3p and miR3p for SA-AKI was evaluated by survival curves. RESULTS: Compared with non-AKI invalids, miR3p and miR3p expressions were obviously lower in the urine of AKI invalids. Furthermore, the area under the curve (AUC) of miR3p and miR3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. CONCLUSIONS: A novel biomarker for the early diagnosis of SA-AKI may be miR3p and miR3p, which was clearly reduced in the urine of SA-AKI patients.
tissue_expression_ns	35860182	hsa-mir-370	Sepsis	OBJECTIVE: This study is aimed at evaluating the miR3p and miR3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. ROC curve was performed to evaluate the diagnostic value of miR3p and miR3p for SA-AKI. The prognostic performance of miR3p and miR3p for SA-AKI was evaluated by survival curves. RESULTS: Compared with non-AKI invalids, miR3p and miR3p expressions were obviously lower in the urine of AKI invalids. Furthermore, the area under the curve (AUC) of miR3p and miR3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. CONCLUSIONS: A novel biomarker for the early diagnosis of SA-AKI may be miR3p and miR3p, which was clearly reduced in the urine of SA-AKI patients.
transcription factor target	35860039	hsa-mir-142	Diabetic Retinopathy	Subsequently, through analyzing GSE84216 from the GEO database, miR5p was markedly upregulated by treatment of muscone in this cell model of cerebral hypoxia injury.
lncRNA target	35860023	hsa-mir-148b	Acute Kidney Injury	Additionally, Virofree elevated miR-148b-5p levels, inhibited the main protease of SARS-CoV-2 (M(pro)), and reduced LPS-induced TNF-alpha release.
genetics_overexpression_suppress	35859793	hsa-mir-100	Thyroid Cancer, Papillary	Thus, we suggest that overexpression of miR
exosome	35859725	hsa-mir-122a	Fibrosis, Renal	These findings indicate that the export of miRNA-122a via MSC-derived exosomes represents a novel strategy to alleviate renal fibrosis.
other	35859315	hsa-mir-137	Inhalant Abuse	In vitro experiments with Neuro2a cells showed that miR3p inversely regulated Nr3c1 mRNA expression, which was upregulated in the HAL group.
lncRNA target	35858900	hsa-mir-4739	Carcinoma, Hepatocellular	CONCLUSION: Our results demonstrate that circGPR137B inhibits HCC tumorigenesis and metastasis through the circGPR137B/miR-4739/FTO feedback loop.
exosome	35858897	hsa-mir-148a	Liver Cirrhosis	Administration of miR-148a-enriched MSC-EXOs or miR-148a agomir shows potent ameliorative effects on liver fibrosis. CONCLUSIONS: These findings suggest that MSC-EXOs protect against liver fibrosis via delivering miR-148a that regulates intrahepatic macrophage functions through KLF6/STAT3 signaling and provide a potential therapeutic target for liver fibrosis.
target gene	35858224	hsa-mir-372	Prostatic Neoplasms	PRDM16, negatively regulated by miR-372-3p, suppresses cell proliferation and invasion in prostate cancer.
exosome	35857905	hsa-mir-20a	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The achieved outcomes explain that CAFs can release miR-20a-containing exosomes capable of promoting NSCLC progression and chemoresistance, highlighting this pathway as a possible therapeutic target in NSCLC.
other	35857794	hsa-mir-552	Angelman Syndrome	SKI axis played critical roles in the proliferation and migration of HBVSMCs and mVSMCs, which were closely involved in atherosclerosis (AS).
other	35857780	hsa-mir-27a	Pyelonephritis	Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05).
other	35857780	hsa-mir-222	Pyelonephritis	Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05).
other	35857780	hsa-mir-27b	Pyelonephritis	Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05).
exosome	35856505	hsa-mir-145	Diabetic Retinopathy	We have also investigated 484 miRNAs in tear exosomes and show miR
exosome	35856505	hsa-mir-9	Diabetic Retinopathy	We have also investigated 484 miRNAs in tear exosomes and show miR
exosome	35856505	hsa-mir-214	Diabetic Retinopathy	We have also investigated 484 miRNAs in tear exosomes and show miR
exosome	35856505	hsa-mir-218	Diabetic Retinopathy	We have also investigated 484 miRNAs in tear exosomes and show miR
genetics_overexpression_suppress	35856354	hsa-mir-429	Carcinoma, Pancreatic Ductal	The overexpression of miR-429 significantly inhibited the proliferation, invasion, and migration of PDAC cells.
circRNA target	35856314	hsa-mir-876	Breast Neoplasms	3p/ACTN4 axis, hinting at a promising therapeutic target for the BC treatment.
other	35855852	hsa-mir-26b	Carcinoma, Hepatocellular	Moreover, we identified a potential lncRNA TUG1/miR-26b-5p/EZH2 regulatory axis in LIHC, which might affect the progression of LIHC. And our study also identified a lncRNA TUG1/miR-26b-5p/EZH2 regulatory axis, which might be of great significance in LIHC progression.
lncRNA target	35855826	hsa-mir-373	Glioma	CONCLUSIONS: ASP suppresses the malignant progression of glioma via regulating the miR
transcription factor target	35855629	hsa-mir-550a	Atherosclerosis	Thus, miR-550a-3p might play a role in atherosclerosis and, for the first time, normalised the function of injured vascular endothelial cells by simultaneous transfection of TM and miR-550a-3p. These results suggest that the miR-550a-3p/TM axis is a potential therapeutic target for atherosclerosis.
exosome	35854778	hsa-mir-766	Colorectal Neoplasms	5p/TRIM67 axis.
circulation_biomarker_diagnosis_down	35854669	hsa-let-7a	Cleft Palate, Non-Syndromic	5p) in plasma exosomes from pregnant women provided higher sensitivity/specificity for diagnosing fetal nsCLP than those in plasma.
genetics_knock down_promote	35853821	hsa-mir-29c	Carcinoma, Hepatocellular	Moreover, ADAM12 knockout or p53 overexpression reduced HCC tumor formation and metastasis, which were reversed by further silencing of miR-29c-3p.
lncRNA target	35853537	hsa-mir-495	Carcinoma, Non-Small-Cell Lung	3p reprograms sphingolipid rheostat towards ceramide by targeting Sphk1 and induces lethal mitophagy to suppress NSCLC tumorigenesis.
lncRNA target	35853280	hsa-mir-20a	Crohn Disease	CONCLUSIONS: Downregulation of miR-20a-5p improved the intestinal epithelial barrier function and prevented CD development through the STAT3/IL-17 signaling pathway.
lncRNA target	35852716	hsa-mir-212	Brain Diseases	5p, aggravated the injury and apoptosis of brain and hippocampus tissues through regulating AKT/GSK3beta/beta-catenin signaling pathway under the CO-poisoning and OGD-treated model, suggesting a selected therapeutic target of DEACMP.
other	35852605	hsa-mir-451b	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
other	35852605	hsa-mir-206	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
other	35852605	hsa-mir-4477a	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
other	35852605	hsa-mir-4796	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
other	35852605	hsa-mir-4311	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
other	35852605	hsa-mir-4795	Glioma	3p (p&lt;0.0001), and microRNA-451b (p&lt;0.0001) in glioma patients compared to controls.
genetics_overexpression_promote	35852131	hsa-mir-602	Stomach Neoplasms	Overexpression of HITT further increased GC cell apoptosis and suppressed the role of miR-602 in inhibiting GC cell apoptosis.
circRNA target	35852112	hsa-mir-940	Prostatic Neoplasms, Castration-Resistant	Conclusion: hsa_circ_0092339 plays a critical role in CRPC through targeting C-MYC indirectly by absorbing hsa-mir-940.
transcription factor target	35851970	hsa-mir-125b	Leukemia, Myeloid, Acute	We also load CD33-targeting RBCEVs with antisense oligonucleotides (ASOs) targeting FLT3-ITD or miR-125b, 2 common oncogenes in AML, and demonstrate that the engineered EVs improve leukaemia suppression in in vitro and in vivo models of AML.
other	35851561	hsa-mir-191	Pancreatic Carcinoma	The results showed that though LR model used to classify this data did not perform well as expected, miRNA-191 and miRNA-4306 still had high recalls (sensitivity), which laid a theoretical foundation for the purpose of using LR model to identify these two miRNAs to jointly diagnose of pancreatic cancer at miRNA level.
other	35851561	hsa-mir-4306	Pancreatic Carcinoma	The results showed that though LR model used to classify this data did not perform well as expected, miRNA-191 and miRNA-4306 still had high recalls (sensitivity), which laid a theoretical foundation for the purpose of using LR model to identify these two miRNAs to jointly diagnose of pancreatic cancer at miRNA level.
lncRNA target	35851058	hsa-let-7c	Mouth Neoplasms	Mechanistically, miR-let-7c in OSCC-derived sEVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived sEVs promote the precancerous transformation of normal epithelial cells, in which the miR-let-7c/p53/PTEN pathway plays an important role.
other	35850658	hsa-mir-224	Pituitary Diseases	CONCLUSION: This indicated a role of hepatic EVs identified by the miR5p in endothelial dysfunction in patients with Low CFR.
other	35850524	hsa-mir-4284	Triple Negative Breast Neoplasms	Innovation: We identified a novel role for miR-4284 in regulating mitochondrial basal proton leak in TNBC cells, and highlighted its significance in TNBC tumor oxidative DNA damage, and its direct correlation with TNBC patient survival.
genetics_knock down_suppress	35850243	hsa-mir-125a	Triple Negative Breast Neoplasms	SIGNIFICANCE: These results indicate that knockdown of ANRIL plays an active role in overcoming drug resistance in TNBC by inhibiting glycolysis through the miR-125a/ENO1 pathway, which may be useful for the development of novel therapeutic targets for treating patients with TNBC, especially those with drug resistance.
other	35850198	hsa-mir-210	Colorectal Neoplasms	A combination signature of these 4 miRNAs (miR-193a-5p, miR-210, miR-513a-5p, and miR3p) yielded an area under the curve of 0.92 (95% confidence interval, 0.85-0.96) for identification of EOCRC in the training cohort.
other	35850198	hsa-mir-193a	Colorectal Neoplasms	A combination signature of these 4 miRNAs (miR-193a-5p, miR-210, miR-513a-5p, and miR3p) yielded an area under the curve of 0.92 (95% confidence interval, 0.85-0.96) for identification of EOCRC in the training cohort.
genetics_knock down_promote	35849320	hsa-mir-197	Glioblastoma	3p inhibitor abolished the effect of circ_0060055 knockdown on GBM cell growth, invasion, and radiosensitivity.
circRNA target	35848890	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Mechanistically, circ_001678 led to the activation of the PD-1/PD-L1 pathway to promote CD8+ T cell apoptosis, thereby inducing NSCLC cell immune escape via regulation of the miR-326/ZEB1 axis. To conclude, our findings revealed that circ_001678 sponges miR-326 to up-regulate ZEB1 expression and induce the PD-1/PD-L1 pathway-dependent immune escape, thereby promoting the malignant progression of NSCLC.
genetics_overexpression_promote	35848848	hsa-mir-146a	Osteoarthritis	Overexpression of miR-146a-5p also reversed the function of BMPR2 overexpression in OA.
transcription factor target	35848125	hsa-mir-21	Colorectal Neoplasms	Together, our data indicated that a natural product, such as tangeretin, can modulate miR-21 expression and that this pathway might be a potential therapeutic target for CRC.
other	35847962	hsa-mir-192	Carcinoma, Hepatocellular	CircKIF5B Promotes Hepatocellular Carcinoma Progression by Regulating the miR-192 Family/XIAP Axis.
transcription factor target	35847904	hsa-mir-200a	Carcinoma, Hepatocellular	Targeting miR-200a-3p and the miR5p/HOXB5/EGFR signaling pathway may provide new options for the treatment strategies of HCC.
genetics_overexpression_suppress	35847592	hsa-mir-27b	Myocardial Reperfusion Injury	This study is aimed at investigating the effect and mechanism of miR-27b-3p underlying hypoxic CMECs-derived exosomes against I/R injury. CONCLUSIONS: These results demonstrated a great therapeutic efficacy of miR-27b-3p overexpression in hypoxic CMEC-derived exosomes in preventing the development of myocardial damage post I/R injury through inhibiting Foxo1/GSDMD signaling-induced oxidative stress and pyroptosis.
circulation_biomarker_diagnosis_ns	35847565	hsa-mir-124	Carotid Stenosis	Moreover, the CEUS parameters combined with serum miR-124 level could improve the performance in predicting ACI and had auxiliary value in evaluating the stability of carotid atherosclerotic plaques.
circulation_biomarker_diagnosis_ns	35847565	hsa-mir-124	Cerebral Infarction, Acute	Moreover, the CEUS parameters combined with serum miR-124 level could improve the performance in predicting ACI and had auxiliary value in evaluating the stability of carotid atherosclerotic plaques.
target gene	35847361	hsa-mir-193a	Uterine Cervical Neoplasms	Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4.
lncRNA target	35847359	hsa-mir-216a	Colonic Neoplasms	The predicted target genes of the LINC00114/miR-216a-5p axis include uromodulin Like 1 (UMODL1) and oncoprotein induced transcript 3 (OIT3), which are closely related to the survival and prognosis of COAD patients.
other	35846077	hsa-mir-146a	Carcinoma, Renal Cell	Association analysis of rs2910164 in the miRNA-146a gene demonstrated that CC genotype and C allele carriers had higher risk of developing severe irAEs (p = 0.03, OR = 6.12; p = 0.01, OR = 2.42, respectively) compare with GG and GC carriers.
other	35846077	hsa-mir-146a	Immune System Diseases	Association analysis of rs2910164 in the miRNA-146a gene demonstrated that CC genotype and C allele carriers had higher risk of developing severe irAEs (p = 0.03, OR = 6.12; p = 0.01, OR = 2.42, respectively) compare with GG and GC carriers.
circulation_biomarker_diagnosis_down	35845963	hsa-mir-16	Sepsis	The area under curve (AUC) of serum miR-4299 and miR
circulation_biomarker_diagnosis_down	35845963	hsa-mir-4299	Sepsis	The area under curve (AUC) of serum miR-4299 and miR
genetics_knock down_promote	35845947	hsa-mir-497	Colonic Neoplasms	Finally, our gain- and loss-of-function experiments evidenced that the lncRNA FGD5-AS1/miR
other	35845940	hsa-mir-182	Small Cell Lung Carcinoma	Furthermore, IHC and qPCR outcomes showed that the expression level of hsa-miR-182, hsa-miR-183, and IGF2BP3 was differentially expressed in normal lung tissues (NLTs) and SCLC tissues (SCLCTs). CONCLUSIONS: Our results concluded that hsa-miR-182, hsa-miR-183, and IGF2BP3 may take part in the development of SCLC.
other	35845940	hsa-mir-183	Small Cell Lung Carcinoma	Furthermore, IHC and qPCR outcomes showed that the expression level of hsa-miR-182, hsa-miR-183, and IGF2BP3 was differentially expressed in normal lung tissues (NLTs) and SCLC tissues (SCLCTs). CONCLUSIONS: Our results concluded that hsa-miR-182, hsa-miR-183, and IGF2BP3 may take part in the development of SCLC.
lncRNA target	35845923	hsa-mir-100	Ovarian Failure, Premature 	NOX4/NLRP3 signaling pathway affects the role of HUCMSCs in an in vitro model of premature ovarian failure through miR
other	35845594	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	5p may play core roles in the regulation of these three genes in HNSCC.
other	35845594	hsa-mir-335	Squamous Cell Carcinoma of Head and Neck	5p may play core roles in the regulation of these three genes in HNSCC.
lncRNA target	35845501	hsa-mir-99a	Uterine Cervical Neoplasms	This study sought to investigate the predictive value of miR-99a for lymphogenous spread and its effect on the survival of patients with early-stage cervical squamous cell cancer (CSCC). CONCLUSIONS: MiR-99a plays an inhibitory role in the pathogenesis of lymph node metastasis and may serve as a novel prognostic biomarker for patients with CSCC.
genetics_overexpression_suppress	35845132	hsa-mir-590	Melanoma	5p is underexpressed in melanoma cells, and its overexpression can inhibit Skp2 expression and proliferation and invasion of melanoma cells.
target gene	35845114	hsa-mir-26b	Ovarian Neoplasms	microRNA-26b inhibits growth and cellular invasion of ovarian cancer cells by targeting estrogen receptor alpha.
other	35845108	hsa-mir-200c	Urinary Bladder Neoplasms	Downregulation of NOTCH1 by hsa-mir-200c/mir-141 may also sensitize tumors to methotrexate thus suggesting potential chemotherapeutic options for bladder cancer subjects.
other	35845108	hsa-mir-141	Urinary Bladder Neoplasms	Downregulation of NOTCH1 by hsa-mir-200c/mir-141 may also sensitize tumors to methotrexate thus suggesting potential chemotherapeutic options for bladder cancer subjects.
transcription factor target	35845054	hsa-mir-206	Diabetes Mellitus, Type 2	CONCLUSIONS: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis.
lncRNA target	35844793	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	Collectively, these results prove that miR-199a-3p/5p can act as cancer suppressor genes to inhibit the mTOR signaling pathway by targeting Rheb, which in turn inhibits the regulatory process of NSCLC.
circulation_biomarker_diagnosis_up	35844239	hsa-mir-21	Postural Orthostatic Tachycardia Syndrome	In the 60-member validation group, the 13 miRNAs were verified again, and it turned out that miR-21 was significantly elevated and could diagnose POTS with a 100% specificity and 92.5% sensitivity. CONCLUSION: Elevated whole-blood miR-21 levels serve as an indicator for POTS and may explain the increased plasma H(2)S observed in POTS sufferers.
genetics_overexpression_promote	35844201	hsa-mir-143	Stomach Neoplasms	3p inhibition or PTBP3 overexpression.
exosome	35844005	hsa-mir-579	Nasopharyngeal Carcinoma	* Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced NPC-SP cell stemness and resistance by the miR
virus_miRNA	35844005	ebv-mir-BART4	Nasopharyngeal Carcinoma	Exosomes loaded with circPARD3 promoted EBV-miR-BART4-induced stemness and cisplatin resistance in NPC-SP cells through the miR-579-3p/SIRT1/SSRP1 axis.
other	35843524	hsa-mir-451	Sepsis	MiR-451 involved in septicemia progression has been reported. However, the underlying mechanism of miR-451 in septicemia induced inflammatory response remains to be revealed.
circulation_biomarker_diagnosis_ns	35843386	hsa-mir-1294	Polycystic Ovary Syndrome	CONCLUSIONS: Plasma miR-1294 along with members of the miR-17/92 cluster and miRNAs involved in insulin signaling may be associated with central obesity and insulin resistance in PCOS.
other	35842702	hsa-mir-502	Carcinoma, Renal Cell	CONCLUSIONS: COLGALT1 could act as a valid immune-related prognostic indicator for KIRC and participated in a ceRNA network of SLC16A1-AS1/hsa-mir3p/COLGALT1, offering one potential biomarker to investigate the mechanism and clinical therapeutic value of KIRC.
genetics_overexpression_promote	35842667	hsa-mir-761	Esophageal Neoplasms	Overexpression of FOXM1 or inhibiting miR-761 restored ESCC cell proliferation and invasion ability after silencing circ-ARAP2. In one word, the results demonstrated that abnormal circ-ARAP2 expression promoted ESCC progression by regulating miR-761/FOXM1 axis-mediated stemness and EMT.
lncRNA target	35842617	hsa-mir-218	Adenocarcinoma of Lung	CONCLUSIONS: Linc00511 acts as a competing endogenous RNA to regulate COL1A1 by targeting miR
lncRNA target	35842617	hsa-mir-126	Adenocarcinoma of Lung	CONCLUSIONS: Linc00511 acts as a competing endogenous RNA to regulate COL1A1 by targeting miR
other	35841247	hsa-mir-134	Alzheimer Disease	Mesenchymal Stem Cells Modulate SIRT1/MiR-134/ GSK3 Signaling Pathway in a Rat Prolonged exposure to environmental aluminum-containing substances is associated with the development of Alzheimer&#x27;s disease (AD).
lncRNA target	35841066	hsa-mir-574	Pancreatic Beta-Cell Dysfunction	CONCLUSIONS: miR3p suppresses glucose toxicity-induced pancreatic beta-cell dysfunction by targeting PRMT1.
exosome	35841008	hsa-mir-23a	Anterior Cruciate Ligament Injuries	CONCLUSIONS: BMSC-Exos promoted M1 macrophage to M2 macrophage polarization via miR-23a-3p, reduced the early inflammatory reaction at the tendon-bone interface, and promoted early healing after ACLR.
transcription factor target	35841005	hsa-mir-132	Cognition Disorders	CONCLUSIONS: Our studies suggest that miR3p cluster-enriched MSC EX promotes the recovery of cognitive function by improving neuronal and synaptic dysfunction through activation of the Ras/Akt/GSK-3beta pathway induced by downregulation of RASA1.
transcription factor target	35841005	hsa-mir-132	Dementia, Vascular	CONCLUSIONS: Our studies suggest that miR3p cluster-enriched MSC EX promotes the recovery of cognitive function by improving neuronal and synaptic dysfunction through activation of the Ras/Akt/GSK-3beta pathway induced by downregulation of RASA1.
lncRNA target	35840974	hsa-mir-27a	Esophageal Squamous Cell Carcinoma	CONCLUSION: Our research demonstrated that splicing factor QKI promotes circBCAR3 biogenesis, which accelerates esophageal cancer tumorigenesis via binding with miR-27a-3p to upregulate TNPO1. CircBCAR3 promoted the proliferation, migration, invasion, and ferroptosis of esophageal cancer cells by miR-27a-3p.
other	35840955	hsa-mir-185	Intervertebral Disc Degeneration	5p-SMAD2.
lncRNA target	35840896	hsa-mir-34a	Cervical Cancer, Hpv Infected	In this study, we report that a micro-RNA, miR-34a by suppressing HPV E6 protein, destabilizes Cdt2/DTL protein level in HPV infected cervical cancer cell lines. This study is the first-ever report to show that miR-34a regulates cell cycle factor Cdt2 by suppressing viral E6 protein level, thus opening up the possibility of exploring miR-34a as a specific therapy for cervical cancer treatment.
lncRNA target	35840794	hsa-mir-365b	Multiple Myeloma	Targets for two specific miRNAs, miR-125b-5p and miR-365b-3p, were functionally validated in MM cell line transfection experiments followed by RNA-sequencing and qPCR.
lncRNA target	35840794	hsa-mir-125b	Multiple Myeloma	Targets for two specific miRNAs, miR-125b-5p and miR-365b-3p, were functionally validated in MM cell line transfection experiments followed by RNA-sequencing and qPCR.
other	35840467	hsa-mir-589	Triple Negative Breast Neoplasms	5p/ HDAC3 axis could be considered as a possible therapeutic strategy in TNBC.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-155	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-451a	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-192	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-146b	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-21	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
circulation_biomarker_diagnosis_ns	35840148	hsa-mir-27a	Arthritis, Juvenile	5p and miR-451a, compared to JIA plasma.
genetics_knock down_promote	35839610	hsa-mir-33a	Colorectal Neoplasms	Moreover, CRC cell invasion and migration as well as xenograft CRC tumor growth suppressed by RASSF8-AS1 overexpression were entirely recovered by RASSF8 knockdown or partially rescued by miR-33a-5p augment. CONCLUSION: RASSF8-AS1 modulates miR-33a-5p/HNRNPC/RASSF8 axis to further impede CRC cell invasion and migration.
genetics_knock down_suppress	35839486	hsa-mir-582	Carcinoma, Hepatocellular	3p-knockdown-mediated promotion of malignant HCC cell phenotypes.
genetics_overexpression_promote	35839114	hsa-mir-17	Stomach Neoplasms	5p on the biological behavior of gastric cancer at the cellular level, by constructing a gastric-cancer cell model that uses overexpressing miR
genetics_knock down_promote	35839011	hsa-mir-194	Osteoporosis	NCF2-Leukocyte transendothelial migration were involved in osteoporosis pathogenesis.
lncRNA target	35838912	hsa-mir-208	Melanoma	Moreover, lncRNA MEG3 inhibited cancer stem cell differentiation and suppressed melanoma progression and metastasis through inhibition of miR-208 by SOX4.
genetics_GWAS	35838216	hsa-mir-124	Depression	Genetic knockdown of hippocampal miR-124 produced significant antidepressant-like effects in the CSDS model of depression.
lncRNA target	35838051	hsa-mir-223	Hepatitis, Alcoholic	RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA).
lncRNA target	35838051	hsa-mir-223	Liver Injury	RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA).
genetics_overexpression_promote	35837990	hsa-mir-630	Carcinoma, Non-Small-Cell Lung	Whereas, VIM overexpression partly attenuated the inhibitory effect of miR-630 on NSCLC cells.
other	35837786	hsa-mir-103	Diabetic Foot	To investigate the relationship between small noncoding microRNA-103 (miR-103) and wound healing of diabetic foot ulcers (DFU) and the underlying molecular mechanism, forty type 2 diabetes mellitus with DFU (DFU group), and 20 patients with a chronic skin ulcer of lower limbs and normal glucose tolerance (SUC group) were included.
other	35837763	hsa-mir-23a	Heart Failure	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
other	35837763	hsa-mir-210	Myocardial Infarction, Acute	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
other	35837763	hsa-mir-210	Heart Failure	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
other	35837763	hsa-mir-221	Myocardial Infarction, Acute	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
other	35837763	hsa-mir-23a	Myocardial Infarction, Acute	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
other	35837763	hsa-mir-221	Heart Failure	3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class.
lncRNA target	35837487	hsa-mir-373	Schimke immunoosseous dysplasia	3p appears to restrict the growth and migration of HTR8 trophoblast cells by targeting SLC38A1, as observed in the placental tissues associated with smaller sIUGR fetuses, and it could have utility in the diagnosis and treatment of this disorder.
target gene	35837196	hsa-mir-383	Stomach Neoplasms	Resveratrol inhibits the proliferation, invasion, and migration, and induces the apoptosis of human gastric cancer cells through the MALAT1/miR-383-5p/DDIT4 signaling pathway.
circulation_biomarker_prognosis_up	35837105	hsa-mir-374a	Colonic Neoplasms	Herein, we first confirmed hsa-miR-374a-3p as a tumor suppressor based on its lower expression in the plasma of patients with COAD with liver metastasis and association with more advanced local progression.
lncRNA target	35837070	hsa-mir-124	Inflammation	Lnc-NEAT1 shRNA or the negative control shRNA were transfected into MMC DN cells, followed by the measurement of cell viability, apoptosis, inflammation, fibrosis and microRNA (miR)-124 expression, a known target of lnc-NEAT1, using Cell Counting Kit-8, flow cytometry, ELISA, western blotting [Capain1 (capn1), beta-catenin (CTNNB1), cleaved caspase 3, cleaved poly-(ADP ribose) polymerase, fibronectin and Collagen] and reverse transcription-quantitative PCR (Capn1, CTNNB1, lnc-NEAT1, fibronectin, collagen and miR-124), respectively. Furthermore, transfection with the miR-124 inhibitor reduced cell apoptosis but increased cell viability, inflammation and fibrosis in lnc-NEAT1-downregulated MMC DN cells.
lncRNA target	35837070	hsa-mir-124	Diabetic Nephropathies	Lnc-NEAT1 shRNA or the negative control shRNA were transfected into MMC DN cells, followed by the measurement of cell viability, apoptosis, inflammation, fibrosis and microRNA (miR)-124 expression, a known target of lnc-NEAT1, using Cell Counting Kit-8, flow cytometry, ELISA, western blotting [Capain1 (capn1), beta-catenin (CTNNB1), cleaved caspase 3, cleaved poly-(ADP ribose) polymerase, fibronectin and Collagen] and reverse transcription-quantitative PCR (Capn1, CTNNB1, lnc-NEAT1, fibronectin, collagen and miR-124), respectively. Furthermore, transfection with the miR-124 inhibitor reduced cell apoptosis but increased cell viability, inflammation and fibrosis in lnc-NEAT1-downregulated MMC DN cells.
genetics_overexpression_promote	35837064	hsa-mir-146b	Diabetic Nephropathies	HIPK1 was validated as the direct target of miR-146b-5p and its overexpression could effectively reduce the effect of miR-146b-5p in contribution to the progression of HF.
other	35837047	hsa-mir-146a	Cardiomyopathies	The present study aimed to investigate the role of miR-146a-5p in isoproterenol (ISO)-induced cardiac fibrosis. Taken together, the results of the present study suggested that the miR-146a-5p/FGF2 pathway may be a novel therapy for cardiac fibrosis.
circulation_biomarker_diagnosis_ns	35837043	hsa-mir-5571	Granulomatous Mastitis	3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM.
circulation_biomarker_diagnosis_ns	35837043	hsa-mir-451a	Granulomatous Mastitis	3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM.
lncRNA target	35836925	hsa-mir-192	Pulmonary Fibrosis	5p alleviates fibrosis and inflammatory responses of tendon cells by targeting NFAT5.
exosome	35836922	hsa-mir-150	Urinary Bladder Neoplasms	Exosomes containing miR
other	35836907	hsa-mir-145	Angelman Syndrome	This study aimed to discuss the effect of miR-145 in AS occurrence and development.
circulation_biomarker_diagnosis_up	35836862	hsa-mir-126	Vasospasm, Intracranial, Postoperative	CONCLUSION: miR-126 is highly expressed in the serum of patients with intracranial aneurysm, so it may be used as a potential biomarker for the diagnosis of patients with intracranial aneurysm and the prediction of cerebral vasospasm after operation.
circulation_biomarker_diagnosis_up	35836862	hsa-mir-126	Intracranial Aneurysm	CONCLUSION: miR-126 is highly expressed in the serum of patients with intracranial aneurysm, so it may be used as a potential biomarker for the diagnosis of patients with intracranial aneurysm and the prediction of cerebral vasospasm after operation.
other	35836847	hsa-mir-661	Pre-Eclampsia	A lncRNA-miRNA-mRNA co-expression network analysis showed that ENST00000559730-hsa-miRNUDT16 was the most frequently associated with susceptibility-relation of PE.
target gene	35836846	hsa-mir-612	Ovarian Neoplasms	miRNA-612 suppresses ovarian cancer cell tumorigenicity by downregulating NOB1.
lncRNA target	35836842	hsa-mir-362	Squamous Cell Carcinoma of Head and Neck	OBJECTIVE: To investigate the mechanism of lncRNA MALAT1 (MALAT1) inhibiting the proliferation and invasiveness of laryngeal squamous cell carcinoma (LSCC) Hep-2 cells by modulating miR
lncRNA target	35836824	hsa-mir-144	Osteoporotic Fracture, Tibial	The bioinformatics website and double luciferase were used to predict the targeting relationship between MALAT1 and miR
lncRNA target	35836520	hsa-mir-614	Breast Neoplasms	3p in suppressing BC metastasis.
target gene	35836485	hsa-mir-1229	Colorectal Neoplasms	Circular RNA 0001666 inhibits colorectal cancer cell proliferation, invasion and stemness by inactivating the Wnt/β-catenin signaling pathway and targeting microRNA-1229.
exosome	35836229	hsa-mir-146a	Pain, Inflammatory	CONCLUSION: Huc-MSCs-derived exosomes attenuated inflammatory pain via miR-146a-5p/TRAF6, which increased the level of autophagy and inhibited pyroptosis.
other	35836137	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	5p/RAP1-NF-kappaB axis is identified to be closely associated with the process.
lncRNA target	35836108	hsa-mir-221	Cardiomegaly	CONCLUSIONS: Our findings suggest that METTL3 positively modulates the pri-miR221/222 maturation process in an m6A-dependent manner and subsequently activates Wnt/beta-catenin signaling by inhibiting DKK2, thus promoting Ang-II-induced cardiac hypertrophy.
lncRNA target	35836107	hsa-mir-145	Nasopharyngeal Carcinoma	5p could repress the proliferation, migration, and invasion of NPC cells via KLF5/FAK regulation, and could be a potential therapeutic target for patients with NPC.
other	35836014	hsa-mir-148a	Hirschsprung Disease	METHODS: The relative expression levels of LINC00346, miR-148a-3p and Dnmt1 in HSCR colon tissues were detected by quantitative real-time PCR.
lncRNA target	35835978	hsa-mir-21	Glioblastoma	We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM.
lncRNA target	35835978	hsa-mir-139	Glioblastoma	We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM.
lncRNA target	35835978	hsa-mir-490	Glioblastoma	We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM.
lncRNA target	35835978	hsa-mir-218	Glioblastoma	We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM.
lncRNA target	35835978	hsa-mir-138	Glioblastoma	We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM.
circRNA target	35835791	hsa-mir-667	Syphilis	5p had potential targeting effects with NLRC4.
circRNA target	35835791	hsa-mir-667	Diabetic Nephropathies	5p had potential targeting effects with NLRC4.
other	35835402	hsa-mir-21	Diabetic Nephropathies	3p) were highly expressed in diabetic kidneys compared to healthy ones.
other	35835402	hsa-mir-214	Diabetic Nephropathies	3p) were highly expressed in diabetic kidneys compared to healthy ones.
other	35835402	hsa-mir-342	Diabetic Nephropathies	3p) were highly expressed in diabetic kidneys compared to healthy ones.
other	35835402	hsa-mir-146a	Diabetic Nephropathies	Also, miR-146a, a marker of kidney inflammation, and mRNA levels of Fn-1 and Nphs, two markers of fibrosis and inflammation, were elevated in DM.
circulation_biomarker_diagnosis_ns	35835374	hsa-mir-148	Prostatic Neoplasms	Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC.
circulation_biomarker_diagnosis_ns	35835374	hsa-mir-185	Prostatic Neoplasms	Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC.
circulation_biomarker_diagnosis_ns	35835374	hsa-mir-145	Prostatic Neoplasms	Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC.
genetics_GWAS	35835333	hsa-mir-124	Leukemia, Myeloid, Acute	Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia.
other	35835254	hsa-mir-21	Nasal Polyps	RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP.
other	35835254	hsa-mir-21	Chronic Rhinosinusitis With Nasal Polyps	RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP.
other	35835254	hsa-mir-21	Nasopharyngitis	RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP.
lncRNA target	35835182	hsa-mir-34a	Coronary Microcirculation Dysfunction	Ligustrazine exerts endothelial-protective, anti-platelet and anti-inflammatory effects to prevent CMD via suppressing miR-34a-5p and promoting Sirt1.
other	35834955	hsa-mir-214	Diabetic Nephropathies	These results suggest that hyperglycemia represses miR3p by inducing lncRNA-CES1P1, which promotes the expression of the inflammatory factors IL-17, IkappaB, NF-kappaB and IL-6 ultimately leading to the development of DN.
other	35834877	hsa-mir-122	Trichohepatoenteric Syndrome	5p/OCLN signaling may be a candidate therapeutic pathway for diarrhea of piglets.
other	35834877	hsa-mir-122	Inflammation	Cytometry kit 8 (CCK-8), lactate dehydrogenase (LDH), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, flow cytometry and fluorescein isothiocyanate-dextran 4 (FITC-Dextran 4) flux assays were performed to study the effect of ALDB-898 and ssc-miR5p in apoptosis, inflammation and intestinal barrier damage and inflammatory in IPEC-J2 cells induced by CPB2.
other	35834877	hsa-mir-122	Enterocolitis, Pseudomembranous	There were lower expression levels of ALDB-898 and OCLN and higher expression levels of ssc-miR5p in diarrhea piglets caused by Clostridium perfringens type C.
other	35834877	hsa-mir-122	Intestinal Diseases	Cytometry kit 8 (CCK-8), lactate dehydrogenase (LDH), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, flow cytometry and fluorescein isothiocyanate-dextran 4 (FITC-Dextran 4) flux assays were performed to study the effect of ALDB-898 and ssc-miR5p in apoptosis, inflammation and intestinal barrier damage and inflammatory in IPEC-J2 cells induced by CPB2.
other	35834034	hsa-mir-155	Pulpitis	In this work, we discovered that the expression of miR-155 was associated with dental pulpal inflammation both in vivo and in vitro.
other	35833845	hsa-mir-26a	Leukemia, Lymphocytic, Chronic, B-Cell	This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL.
other	35833845	hsa-mir-197	Leukemia, Lymphocytic, Chronic, B-Cell	This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL.
genetics_knock down_promote	35833822	hsa-mir-150	late onset Parkinson's disease	Moreover, miR1505p overexpression suppressed ferroptosis in PD cell model. Taken together, knockdown of NEAT1 mitigated MPP+induced ferroptosis through regulating BAP1/SLC7A11 axis by sponging miR1505p, indicating the potential of NEAT1 as a promising therapeutic target for PD.
genetics_knock down_promote	35833822	hsa-mir-150	Siderosis	miR1505p inhibition or BAP1 overexpression mitigated the antiferroptosis effect meditated by shNEAT1.
lncRNA target	35833819	hsa-mir-155	Reperfusion Injury	This investigation aims to explore the neuroprotective role of PA in ischemia/reperfusion via miR155/NRF2/HO1 axis.
lncRNA target	35833665	hsa-mir-577	Colorectal Neoplasms	Furthermore, interference with Linc00883 restrained the proliferation, invasion, and migration of CRC cells through the miR-577/FKBP14 axis. Our results demonstrated that Linc00883 facilitated the proliferation, invasion, and migration of CRC cells by regulating the miR-577/FKBP14 axis.
lncRNA target	35833537	hsa-mir-22	Heart Failure	3p and miR-29a-3p by targeting AKT serine/threonine kinase 3 (AKT3) in HSCs were explored.
other	35833537	hsa-mir-22	Cholestasis	The HF model in cholestatic rats by ligating the common bile duct was induced and the differentially expressed miRNAs in the liver tissues were analyzed by microarray, which showed that miR3p and miR-29a-3p were significantly downregulated in bile-duct ligation (BDL) rat liver compared with the sham control.
other	35833537	hsa-mir-29a	Cholestasis	The HF model in cholestatic rats by ligating the common bile duct was induced and the differentially expressed miRNAs in the liver tissues were analyzed by microarray, which showed that miR3p and miR-29a-3p were significantly downregulated in bile-duct ligation (BDL) rat liver compared with the sham control.
lncRNA target	35833537	hsa-mir-29a	Esophageal Squamous Cell Carcinoma	In addition, cellular senescence was induced and the expressions of the LX-2 fibrosis markers COL1A1 and alpha-SMA were inhibited by miR
other	35833537	hsa-mir-22	De Lange Syndrome	3p and miR-29a-3p were downregulated in activated LX-2 and human primary normal hepatic fibroblasts (NFs), whereas AKT3 was found to be upregulated in BDL rat liver and activated LX-2 cells.
other	35833537	hsa-mir-29a	De Lange Syndrome	3p and miR-29a-3p were downregulated in activated LX-2 and human primary normal hepatic fibroblasts (NFs), whereas AKT3 was found to be upregulated in BDL rat liver and activated LX-2 cells.
lncRNA target	35833537	hsa-mir-22	Esophageal Squamous Cell Carcinoma	In addition, cellular senescence was induced and the expressions of the LX-2 fibrosis markers COL1A1 and alpha-SMA were inhibited by miR
lncRNA target	35833537	hsa-mir-29a	Heart Failure	3p and miR-29a-3p by targeting AKT serine/threonine kinase 3 (AKT3) in HSCs were explored.
genetics_overexpression_promote	35833267	hsa-mir-483	Alzheimer Disease	Finally, XPO1 overexpression rescued the suppressive effect of miR
transcription factor target	35833119	hsa-mir-3	Inflammation	5p to defend against MG infection by inhibiting the JNK signaling pathway.
circRNA target	35833065	hsa-mir-205	Breast Neoplasms	30, and MCF7 are cultured, and the mRNA expressions of hsa_circ_000 1429, miR-205, and KDM4A are detected by qRT-PCR; hsa_circ_000 1429 binds to miR-205, and miR-205 targets KDM4A.
circulation_biomarker_diagnosis_up	35832845	hsa-mir-6727	Stomach Neoplasms	miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients.
circulation_biomarker_diagnosis_up	35832845	hsa-mir-32	Stomach Neoplasms	miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients.
circulation_biomarker_diagnosis_up	35832845	hsa-mir-4741	Stomach Neoplasms	miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients.
circulation_biomarker_diagnosis_up	35832845	hsa-mir-149	Stomach Neoplasms	miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients.
lncRNA target	35832651	hsa-mir-125b	Arthritis, Rheumatoid	Taken together, our study revealed that HQT could attenuate RA through upregulating miR-125b to suppress NF-kappaB-induced inflammation by targeting CK2.
lncRNA target	35832124	hsa-mir-424	Carcinoma, Endometrioid	RESULTS: 1119 differential mRNAs, 14 differential lncRNAs, and 65 differential miRNAs were screened in TCGA; we constructed a ceRNA regulatory network composed of 5 DELs, 7 DEMs, and 90 DEGs; String combined with Cytoscape to screen out Top10 hub genes, namely: LEFTY1, LIN28A, LHX3, ST8SIA3, CEP55, FBXO32, DCN, ANGPTL1, ADRA1A, and KCNMA1; the StarBase database verification results show that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN are downregulated in endometrial cancer tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer; the constructed lncRNA-miRNA-hub Top10 mRNA network map identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis; survival analysis results show that CTD-2314B22, RP11-89 K21, hsa-miR-96, hsa-miR-211, LHX3, ST8SIA3, and DCN are all related to survival; RT-qPCR results indicate CTD-2314B22, RP11-89 K21, LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer cells, and hsa-miR-143 and hsa-miR-424 are downregulated in endometrial cancer cells. CONCLUSION: From the perspective of the lncRNA-miRNA-mRNA network, our study identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis, which can present considerably potent biomarkers and therapeutic targets for treating endometrial cancer.
lncRNA target	35832124	hsa-mir-143	Carcinoma, Endometrioid	RESULTS: 1119 differential mRNAs, 14 differential lncRNAs, and 65 differential miRNAs were screened in TCGA; we constructed a ceRNA regulatory network composed of 5 DELs, 7 DEMs, and 90 DEGs; String combined with Cytoscape to screen out Top10 hub genes, namely: LEFTY1, LIN28A, LHX3, ST8SIA3, CEP55, FBXO32, DCN, ANGPTL1, ADRA1A, and KCNMA1; the StarBase database verification results show that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN are downregulated in endometrial cancer tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer; the constructed lncRNA-miRNA-hub Top10 mRNA network map identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis; survival analysis results show that CTD-2314B22, RP11-89 K21, hsa-miR-96, hsa-miR-211, LHX3, ST8SIA3, and DCN are all related to survival; RT-qPCR results indicate CTD-2314B22, RP11-89 K21, LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer cells, and hsa-miR-143 and hsa-miR-424 are downregulated in endometrial cancer cells. CONCLUSION: From the perspective of the lncRNA-miRNA-mRNA network, our study identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis, which can present considerably potent biomarkers and therapeutic targets for treating endometrial cancer.
lncRNA target	35832084	hsa-mir-155	Acute Kidney Injury	Conclusion: We demonstrated that miR-155 deficiency could significantly attenuate pathological damage and mortality in cAKI through inhibition of TECs apoptosis, genome instability, and telomeric dysfunction, which is possibly regulated by the increasing expression of TRF1 and CDK12.
genetics_knock down_promote	35831436	hsa-mir-1224	Osteoporosis	Furthermore, knockdown of miRNA
genetics_overexpression_promote	35831436	hsa-mir-1224	Fractures, Bone	In addition, in vivo overexpression of miR
transcription factor target	35831436	hsa-mir-1224	Pseudarthrosis	Taken together, these results identify miR5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion.
genetics_overexpression_promote	35831436	hsa-mir-1224	Deficiency Diseases	In addition, in vivo overexpression of miR5p significantly promoted fracture healing and ameliorated the progression of osteoporosis caused by estrogen deficiency or aging.
other	35831411	hsa-let-7b	Sepsis	Sepsis-linked decrease transcription of the classical HLA gene such as HLA-DPB1 and its interplay with miR-let-7b-5p and transcription factor SPIB was observed.
lncRNA target	35831303	hsa-mir-192	Uterine Cervical Neoplasms	Further research showed that miR-192, which plays as a tumor suppressor in CC, was identified as a downstream target of RacGAP1 in CC cells.
genetics_knock down_suppress	35831154	hsa-mir-616	Angelman Syndrome	3p inhibitor stimulated cell proliferation, arrested apoptosis, and caused a decline in the levels of inflammatory factors, whereas knockdown of RFX7 abolished the effects.Circ_0030042 weakened ox-LDL-induced HUVEC injury by regulating the miR
circulation_biomarker_diagnosis_ns	35831141	hsa-mir-188	Myocardial Infarction	The serum levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, CDR1AS, miR
circulation_biomarker_diagnosis_ns	35831141	hsa-mir-188	Depression	The serum levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, CDR1AS, miR
genetics_overexpression_promote	35830966	hsa-mir-548d	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: DLBCL patients with downregulation of hsa-miR-548d-3p and overexpression of HOXA9 mRNA are more likely to experience R-CHOP therapy resistance and disease progression.
genetics_overexpression_promote	35829849	hsa-mir-5088	Squamous Cell Carcinoma of Head and Neck	Overexpression of SLC16A1-AS1 in OSCC cells resulted in inhibited maturation of miR
other	35822682	hsa-mir-155	Osteoarthritis	We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo.
other	35822682	hsa-mir-223	Osteoarthritis	We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo.
other	35822682	hsa-mir-146a	Osteoarthritis	We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo.
other	35822682	hsa-mir-21	Osteoarthritis	We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo.
other	35822676	hsa-mir-200c	COVID-19	Since ACE2 reduces the acute inflammatory effects in lung diseases and acts as a coronavirus receptor to invade the lung cells, this study investigates the relationship between miR-200c-3p and ACE2 expression in COVID -19 patients.
exosome	35822640	hsa-mir-378a	Wounds and Injuries	Conclusion: Exosomal MALAT1 accelerated skin wound healing by regulating the miR-378a/FGF2 axis, suggesting that MALAT1 might be used as a potential target for cutaneous wound treatment.
other	35821682	hsa-mir-26b	Prostatic Neoplasms	The receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p, miR-130a-3p, and miR3p as novel candidates for predicting PCa metastasis.
other	35821682	hsa-mir-130a	Prostatic Neoplasms	The receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p, miR-130a-3p, and miR3p as novel candidates for predicting PCa metastasis.
genetics_overexpression_promote	35821222	hsa-mir-146a	Stomach Neoplasms	The promotion of GC cell proliferation, migration and invasion mediated by LSECtin was largely inhibited by circFBXL4 overexpression or miR-146a-5p silencing. In conclusion, LSECtin might be involved in the lymphatic metastasis of GC by upregulating the expression of FN1 and CHD4 via the circFBXL4/miR-146a-5p/STAT1 axis, possibly indicating a newly discovered pathogenic mechanism.
other	35821197	hsa-mir-21	Breast Neoplasms	MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as being associated with poor prognosis in cancer, we investigated its contribution to mammary tumour growth and metastasis in tumours with capacity for spontaneous metastasis.
lncRNA target	35821145	hsa-mir-22	Alzheimer Disease	3p ameliorated AD by targeting Sox9 through the NF-kappaB signaling pathway in the hippocampus.
exosome	35821021	hsa-mir-139	Urinary Bladder Neoplasms	5p in bone marrow mesenchymal stem The emerging roles of extracellular vesicles (EVs) in bladder cancer have recently been identified.
lncRNA target	35821018	hsa-mir-143	Reperfusion Injury	Mechanistically, mmu_circ_0000021 involved in regulating microvascular dysfunction via miR3p by targeting NPY.
other	35820565	hsa-mir-145	Diabetes Mellitus, Type 1	5p and albuminuria that was mediated by systemic hypertension.
lncRNA target	35819589	hsa-mir-507	Stomach Neoplasms	MiR-507 has been confirmed as a tumor inhibitor which can suppress the progression of multiple cancers while its role in GC remains unknown.
lncRNA target	35819551	hsa-mir-195	Stomach Neoplasms	The downregulated SNHG1 hinders the biological behaviors of GC cells via the modulation of the miR
other	35819446	hsa-mir-146b	Leukemia, Lymphocytic, Chronic, B-Cell	MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells.
lncRNA target	35818964	hsa-mir-654	Stomach Neoplasms	Together, this study showed that circ_0067514 suppressed gastric cancer aggressive development and glycolysis via miR
other	35818915	hsa-mir-487a	Carcinoma, Renal Cell	CONCLUSION: The enhanced expression of miR-487a was related to the prognosis of ccRCC, and it also facilitated cell proliferation, migration, and invasion.
other	35818817	hsa-mir-24	Pre-Eclampsia	3p in regulating RBP4 during trophoblast dysfunction and PE development.
genetics_knock down_promote	35818779	hsa-mir-497	Colorectal Neoplasms	5p overexpression suppressed CRC cell growth, invasion and glutamine metabolism, and SLC7A5 was able to revoke this effect.
transcription factor target	35818586	hsa-mir-127	Meningioma	CONCLUSION: miR5p regulated meningioma formation and ferroptosis through JAM3, providing insights for the development of new treatments for meningioma.
other	35818274	hsa-mir-27b	Tuberculosis	tuberculosis-infected macrophages, the expression level of BAG2 decreased from (284.24+/-6.31) to (156.48.24+/-4.49), and the expression level of miR-27b was increased from (43.72+/-3.35) to (78.35+/- 4.17), the apoptosis rate increased by 17.8%, and the autophagy rate increased by 20.6%.
lncRNA target	35818268	hsa-mir-494	Uterine Cervical Neoplasms	The purpose of this article is to further explore the effectiveness of miR-494 in inhibiting the proliferation, migration and invasion of CC cells by regulating LETMD1, selecting 40 cases of CC admitted to a hospital from June 2015 to September 2018 Patients, tumor tissue specimens were taken from the primary tumor tissue of CC, and normal tissues near the cutting edge were collected as controls. After high expression of miR-494 in CC patients, the vascular invasion of CC cells was reduced by 33%, and distant metastasis was reduced by 11%, and the survival time of patients was significantly prolonged.
lncRNA target	35818262	hsa-mir-182	Bone Diseases	The results showed that protein expression levels of RANKL, OPG and CXCL10 in the miR-182 group were significantly higher than those in other groups (P>0.01). In general, miR-182 alleviates OP by inhibiting the activity of osteoclast via RANKL/NFkappaB signaling.
transcription factor target	35818261	hsa-mir-494	Uterine Cervical Neoplasms	This study focused on miR-494 inhibiting the proliferation, migration and invasion of cervical cancer cells by regulating HCCR1. The qRT-PCR results showed that compared with the normal cervical tissue cell line HCCR1, the expression levels of miR-494 in cervical cancer cell lines HCCR1 and C-33A were significantly reduced.
transcription factor target	35818253	hsa-mir-129	Colonic Neoplasms	5p had a more substantial effect on the proliferation and apoptosis of CC by targeting RSF1.
lncRNA target	35818245	hsa-mir-143	Breast Neoplasms	3p can increase the radiosensitivity of breast cancer cells through FGF1.
circulation_biomarker_diagnosis_up	35818240	hsa-mir-145	Thyroid Cancer, Papillary	In general, the expression of miRNA-22l in serum of PTC patients is significantly up-regulated, while the expression level of miR-145 is down-regulated, which can be used as effective indicators to judge the biological activity of the tumor, and the combined detection of the two can significantly enhance the diagnostic value of PTC. Upregulation of miR-145 inhibits PTC cell proliferation; arrests cell cycle and promotes apoptosis miR-145 may play an important role as a tumor suppressor gene.
other	35818240	hsa-mir-221	Thyroid Cancer, Papillary	This study aimed to investigate the expression of miR-221 and miR-145 in papillary thyroid carcinoma, and the effect of miR-221 and miR-145 on the invasion ability of thyroid cancer cells and its mechanism.
circulation_biomarker_prognosis_up	35818236	hsa-mir-27a	Heart Failure	The difference of miR-27a expression level in serum exosomes between the two groups of subjects was compared, so as to analyze the diagnostic value of miR-27a in CHF and the relationship between miR-27a expression level and patient prognosis.
lncRNA target	35818227	hsa-mir-124	Sepsis	The results showed that AKT1, MMP9, ARG1, ETS1 targeting AKT1, and has-miR3p targeting RPS6KA5 may have diagnostic value for patients with sepsis and septic shock.
other	35818213	hsa-mir-144	Glioma	The expressions of Mir-HCG11, Mir3p and COX-2 in each group were observed, and the proliferation and apoptosis of glioma cells were analyzed, and their drug resistance was analyzed.
other	35818205	hsa-mir-135a	Hepatoblastoma	In this experiment, we used in vitro culture of hepatoblastoma cells and flow cytometry to detect the effect of miRNA-135a on the tumor cell cycle.
circulation_biomarker_diagnosis_ns	35818203	hsa-mir-145	Ovarian Neoplasms	The miR-145 recombinant plasmid and the empty plasmid into OC cells were transfected, and qRT-PCR was used to detect the expression of miR-145 in the transfected OC cells.
other	35818196	hsa-mir-513b	Lung Neoplasms	The expressions of circ_UHRF1 and miR-513b-5p in lung cancer tissues were negatively correlated (r=-0.861, P<0.05).
target gene	35818076	hsa-mir-3173	Prostatic Neoplasms	LINC00893 inhibits the progression of prostate cancer through miR-3173-5p/SOCS3/JAK2/STAT3 pathway.
lncRNA target	35818041	hsa-mir-199a	Adenocarcinoma, Follicular	In addition, we found that PD-L1 expression was positively correlated with Claudin-1 expression and that miR-199a-5p affected the progression of FTC cells through the negative regulation of PD-L1 and Claudin-1.
circulation_biomarker_diagnosis_up	35817886	hsa-mir-671	Atherosclerosis	5p expression was decreased in the serum of patients with AS and in ox-LDL-treated HUVECs.
exosome	35817771	hsa-mir-370	Glioma	Our results demonstrate for the first time that exosome-mediated delivery of circWDR62 can promote TMZ resistance and malignant progression via targeting of the miR
lncRNA target	35817571	hsa-mir-155	Lupus Erythematosus, Systemic	In addition, we identified PSMB10, PSMB4, TAF10, NFKappaBIA and miR-155 involved in the common pathogenesis as potential biomarkers and therapeutic targets for DLBCL.
lncRNA target	35817571	hsa-mir-155	Lymphoma, Large B-Cell, Diffuse	In addition, we identified PSMB10, PSMB4, TAF10, NFKappaBIA and miR-155 involved in the common pathogenesis as potential biomarkers and therapeutic targets for DLBCL.
genetics_knock down_suppress	35817473	hsa-mir-29a	Uterine Cervical Neoplasms	CONCLUSION: In this research, knockdown of HOXA-AS3 could alleviate the process of cervical cancer by sponging miR-29a-3p, suggesting that HOXA-AS3 may be a potential prognostic target of cervical cancer, which could provide a theoretical basis for future clinical research of cervical cancer.
lncRNA target	35817112	hsa-mir-137	Prostatic Neoplasms	These findings suggest that endosulfan can indeed promote cell migration and invasion via the KCNQ1OT1/miR3p/PTP4A3 axis in PCa cells.
exosome	35816980	hsa-mir-29	Skeletal Muscle Injury	Here, a silk sericin patch delivering miRNAenriched extracellular vesicles-decorated myoblasts (SPEED) is designed for the rapid regeneration and functional repair after severe skeletal muscle injury.
other	35816613	hsa-mir-889	Carcinoma, Hepatocellular	5p/KLF9 axis for HCC progression, and we postulate that blocking this key signaling pathway may represent a promising strategy for HCC treatment.
other	35816558	hsa-mir-326	Carcinoma, Hepatocellular	CONCLUSIONS: E2F1-activated SNHG1 modulates the miR-326/PKM2 axis to facilitate glycolysis and the proliferation of HCC cells.
lncRNA target	35816228	hsa-mir-627	Colonic Neoplasms	5p suppressed colon cancer growth.
lncRNA target	35815670	hsa-mir-17	Arthritis, Rheumatoid	5p and inhibiting STAT3.
other	35815280	hsa-mir-491	Stomach Neoplasms	3p expression was found in gastric cancer, being a high diagnostic efficiency and an independent risk factor for gastric cancer, especially in those having LNM.
circulation_biomarker_diagnosis_up	35814945	hsa-mir-21	Coronary Artery  Disease	The expressions of plasma mir-21 were evidently and progressively higher while PDCD4 levels were significantly and steadily lower in single-, dual-, and multivessel occluded CAD patients than in healthy participants (P < 0.001).
transcription factor target	35814901	hsa-mir-451	Retinal Neovascularization	miRNA-451 can be a protective factor for neovascular disease of fundus via regulating choroid retinal endothelial cell function.
other	35814832	hsa-mir-486	Colonic Neoplasms	On the whole, the findings of the present study suggest that PVT1 promotes the resistance of colon cancer cells to 5-FU by regulating the miR5p/CDK4 axis.
lncRNA target	35814830	hsa-mir-1827	Prostatic Neoplasms	Notably, lncRNA SNHG3 promoted PCa progression through miR-1827 via the Wnt/AKT/mTOR pathway.
other	35814566	hsa-mir-675	Stomach Neoplasms	3p.
target gene	35814430	hsa-mir-658	Stomach Neoplasms	Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway.
lncRNA target	35814429	hsa-mir-378a	Colorectal Neoplasms	Silencing of miR-378a-3p targets, MALAT1 and NEAT1, significantly impairs tumorigenic properties of CRC-SCs, supporting the critical role of miR-378a-3p in CRC carcinogenesis as a tumor-suppressor factor by establishing a finely tuned crosstalk with lncRNAs MALAT1 and NEAT1.
exosome	35814269	hsa-mir-224	Colorectal Neoplasms	CONCLUSION: These findings suggested that SW620 cell-derived exosomal miR
exosome	35814268	hsa-mir-431	Intervertebral Disc Degeneration	Collectively, BMSC-EV-loaded circ_0072464 inhibited NPC ferroptosis to relieve IDD via upregulation of miR
transcription factor target	35814248	hsa-mir-96	Brain Injuries, Traumatic	5p, and up-expression of inflammatory cytokines, which were all inhibited by miR
target gene	35813866	hsa-mir-1178	Stomach Neoplasms	Circ_0110940 Exerts an Antiapoptotic and Pro-Proliferative Effect in Gastric Cancer Cells via the miR-1178-3p/SLC38A6 Axis.
tissue_expression_ns	35813630	hsa-mir-335	Dwarfism, Pituitary	3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment.
tissue_expression_ns	35813630	hsa-mir-199a	Dwarfism, Pituitary	3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment.
tissue_expression_ns	35813630	hsa-mir-494	Dwarfism, Pituitary	3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment.
other	35813482	hsa-mir-584	Squamous Cell Carcinoma of Head and Neck	Mechanistically, miR5p downregulation may lead to the upregulation of SQLE in HNSCC.
other	35813473	hsa-mir-340	Pancreatic Carcinoma	3p/HTR1D ceRNA axis acted a crucial part in the malignant biological behavior of pancreatic cancer in an AKT-dependent manner.
circulation_biomarker_diagnosis_up	35813421	hsa-mir-124	Depression	3p asponge lentiviral suspension was given to determine the weight of rats and open-field test, sugar preference experiment, Serum CORT, 5-HT, DA, and NE were measured, observe and record the behavior of rats, including behavior, diet, and hair.
other	35813414	hsa-mir-139	Gout	CONCLUSION: Characterization of ceRNA networks could be a promising approach for better understanding the pathogenesis of gout, with the TTTY10/hsa-miR5p/AP-1 axis likely to be of clinical significance.
lncRNA target	35813344	hsa-mir-187	Hemangioma	miR3p has previously been confirmed to promote or inhibit various malignancies, but its role in the development and progression of IH remains unclear.
other	35812757	hsa-mir-195	Breast Neoplasms	Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer.
other	35812757	hsa-mir-26b	Breast Neoplasms	Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer.
other	35812757	hsa-mir-26a	Breast Neoplasms	Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer.
other	35812757	hsa-let-7b	Breast Neoplasms	Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer.
lncRNA target	35812732	hsa-mir-223	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
lncRNA target	35812732	hsa-mir-16	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
lncRNA target	35812732	hsa-mir-15b	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
lncRNA target	35812732	hsa-mir-200c	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
lncRNA target	35812732	hsa-mir-130a	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
lncRNA target	35812732	hsa-mir-142	Papillomavirus Infections	5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes.
circulation_biomarker_diagnosis_ns	35812667	hsa-mir-199a	Colorectal Neoplasms	Further validation in an independent cohort revealed that both circulating miR5p and miR-199a-5p were sequentially increased from HCs and AAs to CRCs.
circulation_biomarker_diagnosis_up	35812667	hsa-mir-627	Colorectal Neoplasms	5p were markedly increased in patients with colorectal neoplasms and showed strong potential as minimally invasive biomarkers for the early screening of colorectal neoplasms.
transcription factor target	35812439	hsa-mir-513a	Carcinoma, Hepatocellular	Results of the cell counting kit 8 (CCK8), 5-ethynyl-2'-deoxyuridine (EdU), transwell, wound healing test, and flow cytometry showed that GUSB facilitated proliferation, invasion, as well as migration of human HCC cells and downregulated PD-L1 expression by promoting miR-513a-5p. In summary, this study reveals that increased GUSB downregulates PD-L1 expression by promoting miR-513a-5p, leading to primary resistance to anti-PD1 treatment in HCC, and amoxapine enhances the sensitivity of anti-PD1 therapy by inhibiting GUSB, providing a new strategy and method for improving the efficacy of anti-PD1 therapy and bringing new prospects for therapy of HCC.
other	35812382	hsa-mir-372	Cholestasis, Intrahepatic	Further evidence suggested that the expression of immune-related genes KLRD1, BRAF, and NFATC4 might have a potential ceRNA mechanism by individual lncRNA sponging miR372-3p, miR-371a-3p, miR3p, and miR-449a to control downstream the level of TNF-alpha, IFN-gamma, and IL-10, thereby regulating the pathophysiology of ICP.
lncRNA target	35812178	hsa-mir-21	Pancreatic Carcinoma	In the present study miR-21 was characterized and its upstream regulatory mechanism was investigated, as well as its functional effects and target genes in pancreatic ductal adenocarcinoma (PDAC).
lncRNA target	35812136	hsa-mir-195	Bone Diseases	CONCLUSION: These results demonstrate that CORM-3 promoted osteogenic differentiation of rat BMSCs via miR5p/Wnt3a, which bodes well for the application of CORM-3 in the treatment of periodontal disease and other bone-defect diseases.
lncRNA target	35812136	hsa-mir-195	Periodontal Diseases	CONCLUSION: These results demonstrate that CORM-3 promoted osteogenic differentiation of rat BMSCs via miR5p/Wnt3a, which bodes well for the application of CORM-3 in the treatment of periodontal disease and other bone-defect diseases.
genetics_overexpression_promote	35812061	hsa-mir-1200	Osteosarcoma	Moreover, miR-1200 overexpression significantly alleviated the inhibitory effect of circNRIP1 on OS cells.
other	35812058	hsa-mir-133b	Prostatic Neoplasms	In conclusion, the ceRNA network of lncHUPC1/miR-133b/SDCCAG3 affected the growth and apoptosis of PCa cells, and FOXA1 may be involved in the process as a transcription factor of lncHUPC1.
other	35812044	hsa-mir-1179	Triple Negative Breast Neoplasms	CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer.
transcription factor target	35811894	hsa-mir-603	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811894	hsa-mir-923	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811894	hsa-mir-2052	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811894	hsa-mir-365a	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811894	hsa-mir-7113	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811894	hsa-mir-3065	Hypertension	5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms.
transcription factor target	35811845	hsa-mir-204	Neuroblastoma	Our study demonstrates that TTF1 reduces tumor growth and induces neurogenic differentiation in NB by directly targeting TrkA and the miR-204/TrkB axis.
genetics_overexpression_promote	35811549	hsa-mir-99b	Prostatic Neoplasms	In PCa cell lines, overexpression of miR-99b inhibited cell proliferation and cell colony/spheroid formation; induced apoptosis, and increased sensitivity towards docetaxel (DTX).
circulation_biomarker_diagnosis_up	35811521	hsa-mir-150	Alzheimer Disease	5p is a promising clinical blood-based biomarker for DAT.
lncRNA target	35810770	hsa-mir-23b	Cataract, Age-Related	Circ_0060,144 and HIPK3 mRNA expression were decreased in ARC tissues, and miR-23b-3p was increased. Circ_0060,144 promoted ARC development via regulation of miR-23b-3p/HIPK3 axis.
lncRNA target	35810742	hsa-mir-181a	Small Cell Lung Carcinoma	CONCLUSION: Our data emphasized the anti-inflammatory actions of miR-181a by targeting TNF-alpha in the context of renal inflammation in DN.
lncRNA target	35810742	hsa-mir-181a	Diabetic Nephropathies	CONCLUSION: Our data emphasized the anti-inflammatory actions of miR-181a by targeting TNF-alpha in the context of renal inflammation in DN.
lncRNA target	35810709	hsa-mir-101	Rhabdomyosarcoma 1	In conclusion, our results revealed that LINC01347 suppresses the migratory ability and regulates the EMT processes in trophoblasts by regulating miR3p/PTEN/AKT axis, suggesting that targeting LINC01347 may serve as a strategy to ameliorate RM.
lncRNA target	35810663	hsa-mir-29b	Acute Lung Injury	CONCLUSION: Our results reveal that WIN inhibits macrophage glycolysis through the miR-29b-3p/ FOXO3/PFKFB3 axis, suggesting new therapeutic targets to alleviate sepsis-related ALI.
lncRNA target	35810662	hsa-mir-27b	Pulmonary Arterial Hypertension	In addition, in MCT-induced PAH rats, targeting ETAR/miR-27b-3p/FBXW7/KLF5/GLI1 pathway effectively prevented the pulmonary vascular remodeling and the development of PAH in rats. Our study indicates that interfering ETAR/miR-27b-3p/FBXW7/KLF5/GLI1 signaling axis might have a potential value in the prevention and treatment of PAH.
lncRNA target	35809813	hsa-mir-340	Pre-Eclampsia	Upregulation of lncRNA XIST exerted the inhibitory effects on the proliferation and invasion of trophoblast cells through the interactions with miR
genetics_knock down_suppress	35809451	hsa-mir-335	Bronchopulmonary Dysplasia	RESULTS: Firstly, SNHG6 was highly expressed and miR-335 was lowly expressed in BPD model, SNHG6 knockdown and miR-335 mimics both alleviated hyperoxia-induced lung cell injury, and SNHG6 targeted miR-335.
genetics_knock down_suppress	35809451	hsa-mir-335	Hyperoxia-Induced Lung Injury	RESULTS: Firstly, SNHG6 was highly expressed and miR-335 was lowly expressed in BPD model, SNHG6 knockdown and miR-335 mimics both alleviated hyperoxia-induced lung cell injury, and SNHG6 targeted miR-335.
other	35809377	hsa-mir-460a	Branchio-Oto-Renal Syndrome	The present study explored the molecular mechanism of CGA on chondrocytes' apoptosis with B-cell lymphoma 2 signaling under the effect of miR-460a. RESULTS: The CGA decreased the apoptosis rate with the deactivation of miR-460a, accompanied by the activation of Bcl-2.
circulation_biomarker_diagnosis_ns	35809332	hsa-mir-214	Carcinoma, Hepatocellular	MTT, cell cycle and construct recombinant plasmids analysis were used to explore the effects of miR-214 and PTK2b/Pyk2 on liver cancer cell proliferation.
other	35809331	hsa-mir-146a	Lumbar Disc   Herniation	Then upregulation of miR-146a could reduce the activity of the TLR4 signaling pathway and the release of pro-inflammatory factors, which may be a potential strategy for the treatment of lumbar disc herniation.
circulation_biomarker_diagnosis_up	35809326	hsa-mir-1	Hypertension	3p expression and low serum BDNF levels in patients with primary hypertension complicated with depression.
circulation_biomarker_diagnosis_up	35809326	hsa-mir-1	Depression	3p expression and low serum BDNF levels in patients with primary hypertension complicated with depression.
genetics_overexpression_suppress	35809318	hsa-mir-140	Osteosarcoma	Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/beta-catenin signaling.
genetics_overexpression_promote	35809317	hsa-mir-145	Myocardial Reperfusion Injury	Overexpression of miR5p can downregulate the expression of GIGYF1, further promote cell proliferation, inhibit cell apoptosis, alleviate inflammation and oxidative stress, and hence exert a protective role in myocardial infarction IRI.
lncRNA target	35809316	hsa-mir-19b	Osteoporosis	It was concluded the inhibition of miR-19b-3p has a suppressive effect on the development of OP and the function of miR-19b-3p in OP is likely to be achieved by regulating the expression of the IGF-1 gene.
genetics_GWAS	35809314	hsa-mir-191	Breast Neoplasms	Furthermore, NextSeq 500 revealed that a single nucleotide polymorphism (C>T) newly occurred in the mature sequence of miR5p seed region in BRCA samples.
other	35809313	hsa-mir-1	Colorectal Neoplasms	In general, miR -34a-3p, miR -31, and PLEK2 are closely associated with the occurrence and development of colorectal cancer, and they are all influential factors affecting the prognosis of patients with colorectal cancer, which can provide a basis for the evaluation and treatment of patients, and are worthy of widespread clinical application.
other	35809313	hsa-mir-34a	Colorectal Neoplasms	The expressions of miR -34a-3p, miR -31, and PLEK2 in colon cancer tissues and normal cancer tissues were compared, and the correlation between miR -34a-3p, miR -31, and PLEK2 and clinic-pathological characteristics of colorectal cancer patients were analyzed.
circulation_biomarker_diagnosis_up	35809311	hsa-mir-145	Pre-Eclampsia	Conclusion: the serum level of Gas6 was reduced in patients with early-onset preeclampsia, and TNF-a inhibited the invasion of SVneo cells by upregulating mir
tissue_expression_ns	35809289	hsa-mir-21	Abortion, Spontaneous	Therefore, the present study evaluated the effect of post-abortion care (PAC) on anxiety in women with spontaneous abortion based on MicroRNA-21 expression, cortisol level, and Fordyce happiness pattern.
tissue_expression_ns	35809289	hsa-mir-21	Anxiety Disorders	Therefore, the present study evaluated the effect of post-abortion care (PAC) on anxiety in women with spontaneous abortion based on MicroRNA-21 expression, cortisol level, and Fordyce happiness pattern.
other	35809285	hsa-mir-155	Diabetes Mellitus	It is concluded that PPARgamma, Abeta1-42, miR-155 are closely related to the occurrence and development of diabetes, and there are many influencing factors of diabetes.
lncRNA target	35808943	hsa-mir-144	Ovarian Neoplasms	3p inhibitor notably decreased autophagy.
lncRNA target	35807865	hsa-mir-21	Colitis	Taken together, our results revealed that GTP inhibits DSS-induced colonic inflammation by suppressing miR-21 expression and NF-kappaB activity, suggesting that it may be used as a potential functional material for improving colitis.
other	35807864	hsa-mir-21	Hypertension	In conclusion, hypovitaminosis D correction ameliorated the cardiovascular risk profiles in hypertensive patients treated with cholecalciferol but did not influence the miR-21 expression.
other	35807767	hsa-mir-145	Uremia	Vitamin D treatment from week 8 to 14 fully prevented the reductions in aortic miR-145 and attenuated by 50% the decreases in alpha-actin, despite uremia-induced hyperphosphatemia. In conclusion, vitamin D was able to prevent the reductions in aortic miR-145 and alpha-actin content induced by uremia, reducing the alterations in vascular contractility and osteogenic differentiation despite hyperphosphatemia.
other	35807767	hsa-mir-145	Hyperphosphatemia	Vitamin D treatment from week 8 to 14 fully prevented the reductions in aortic miR-145 and attenuated by 50% the decreases in alpha-actin, despite uremia-induced hyperphosphatemia. In conclusion, vitamin D was able to prevent the reductions in aortic miR-145 and alpha-actin content induced by uremia, reducing the alterations in vascular contractility and osteogenic differentiation despite hyperphosphatemia.
genetics_GWAS	35807118	hsa-mir-125a	Abortion, Habitual	A total of 150 women that had experienced two or more RPLs and 180 healthy controls (two or more full-term pregnancies) were recruited, along with 50 product of conception (POC) samples from the corresponding RPL patients, and evaluated for miR-125a SNPs by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), which was confirmed by high resolution melting (HRM)/DNA sequencing.
other	35806488	hsa-mir-17	Head and Neck Neoplasms	3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC).
other	35806488	hsa-mir-140	Head and Neck Neoplasms	3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC).
other	35806488	hsa-mir-874	Head and Neck Neoplasms	3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC).
transcription factor target	35806291	hsa-mir-497	Lung Neoplasms	We also demonstrated that SREBP-1/SCAP/FASN lipogenic signaling plays a key role in CSCs-like and chemoresistant NSCLC phenotypes, especially because the fatostatin or shRNA targeting of SREBP-1 significantly suppressed the viability, cisplatin resistance, and cancer stemness of NSCLC cells and because treatment induced the expression of hsa-miR-497. CONCLUSION: Targeting the SREBP-1/hsa-miR-497 signaling axis is a potentially effective anticancer therapeutic strategy for NSCLC.
exosome	35806142	hsa-mir-203a	Carcinoma, Non-Small-Cell Lung	In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients.
exosome	35806142	hsa-mir-203a	Small Cell Lung Carcinoma	In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients.
other	35806139	hsa-mir-574	Prostatic Neoplasms, Castration-Resistant	5p) could be used as potential biomarkers for the prognosis of CRPC.
other	35806139	hsa-mir-21	Prostatic Neoplasms, Castration-Resistant	5p) could be used as potential biomarkers for the prognosis of CRPC.
transcription factor target	35805966	hsa-mir-1183	Tachycardia	In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease.
other	35805964	hsa-mir-204	Alzheimer Disease	By combining different in vitro model systems of DA differentiation, we show that the levels of Lmx1a influence the expression of miR-204/211. We further demonstrated that miR-204/211 controls the timing of the DA differentiation by directly downregulating the expression of Nurr1, a late DA differentiation master gene.
lncRNA target	35805891	hsa-mir-181a	Brain Injury, Ischemic	Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.
genetics_knock down_promote	35805200	hsa-mir-9	Carcinoma, Hepatocellular	Gain- and loss-of-function studies demonstrated that miR
lncRNA target	35805086	hsa-mir-146b	Ataxia Neuropathy Spectrum	The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b, which are both known to suppress a variety of immune responses.
other	35805015	hsa-mir-137	Stomach Neoplasms	COL5A1 Promotes the Progression of Gastric Cancer by Acting as a ceRNA of miR-137-3p to Upregulate FSTL1 Expression.
genetics_overexpression_promote	35804897	hsa-mir-134	Nasopharyngeal Carcinoma	Lastly, using an in vivo lung metastasis assay, we showed that ICG-001 transient overexpression of miR-134 or stable overexpression of miR-134 could significantly reduce the lung metastasis of NPC cells.
other	35804809	hsa-mir-224	Carcinoma, Hepatocellular	These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients.
other	35804809	hsa-mir-607	Carcinoma, Hepatocellular	These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients.
other	35804809	hsa-mir-424	Carcinoma, Hepatocellular	These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients.
other	35804809	hsa-mir-150	Carcinoma, Hepatocellular	These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients.
other	35804809	hsa-mir-199a	Carcinoma, Hepatocellular	These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients.
genetics_knock down_suppress	35804263	hsa-mir-431	Thyroid Neoplasms	5p downregulation reversed the role of circRTN1 knockdown in TC cells.
genetics_overexpression_promote	35803492	hsa-mir-93	Hypoxia-Ischemia, Brain	Importantly, MSC-derived EVs overexpressing miR-93 suppressed HDAC4 expression and subsequently impeded the apoptosis of OGD-exposed hippocampal neurons in vitro, and also ameliorated HIBD in vivo. Taken together, miR-93 delivered by MSC-derived EVs can ameliorate HIBD by suppressing hippocampal neuron apoptosis through targeting the HDAC4/Bcl-2 axis, a finding which may be of great significance in the treatment of HIBD.
transcription factor target	35802903	hsa-mir-224	Fibrosis	In vivo results show that treatment with antagomir-224 or liposomes containing miR-224 inhibitors suppresses fibrosis and improves muscle recovery.
exosome	35802880	hsa-mir-375	Breast Neoplasms	The biomimetic vesicles prepared with MCF-7 cancer cell-derived membranes were shown to recognize estrogen receptor-positive breast cancer exosomes and exhibited a low detection limit of 557 particles mL(-1) with microRNA-375 used as the endogenous biomarker.
lncRNA target	35802304	hsa-mir-487b	Spinal Cord Injuries	For the first time, our results revealed that miR-487b may play an important regulatory role in SCI by targeted Ifitm3 and provide further evidence for SCI research.
lncRNA target	35802246	hsa-mir-34b	Depression, Post Stroke	Together, our data demonstrated that insufficient miR34b-3p after stroke cannot inhibit eIF4E translation, which causes PSD by the activation of microglia in the hippocampus. Therefore, miR34b-3p and eIF4E may serve as potential therapeutic targets for the treatment of PSD.
transcription factor target	35802043	hsa-mir-150	Osteoporosis	The data showed that diabetes upregulated miR-150 expression through oxidative stress and suppressed FNDC5/Irisin by binding to its 3'-untranslated region.
genetics_GWAS	35800619	hsa-mir-27b	Carcinoma, Hepatocellular	Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation.
genetics_GWAS	35800619	hsa-mir-27b	Hepatitis B, Chronic	Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation.
target gene	35800618	hsa-mir-139	Osteosarcoma	LINC01140 regulates osteosarcoma proliferation and invasion by targeting the miR-139-5p/HOXA9 axis.
other	35800215	hsa-mir-29b	Muscular Atrophy	Med1, Myod1, Nfkb1, Rela, and Camta1 were predicted and verified to be significantly upregulated in denervated muscle atrophy, from which 6 key TF-miRNA relationship pairs, including Med1-mir-1949, Med1-mir-146b, Myod1-mir-29b, Nfkb1-mir-21, Rela-mir-21, and Camta1-mir-132, were obtained. In the study, a potential miRNA-mRNA regulatory network was firstly constructed in denervated muscle atrophy, in which the mir-29b-COL1A1 and mir-133a-Ctgf pathways may provide new insights into the pathogenesis and treatment.
lncRNA target	35799888	hsa-mir-1224	Acute Lung Injury	5p is directly bound to the 3'-untranslated regions of PPAR-gamma and subsequently suppressed PPAR-gamma/AMPKalpha axis, thereby aggravating LPS-induced ALI in vivo and in vitro.
lncRNA target	35799888	hsa-mir-1224	Sepsis	5p is directly bound to the 3'-untranslated regions of PPAR-gamma and subsequently suppressed PPAR-gamma/AMPKalpha axis, thereby aggravating LPS-induced ALI in vivo and in vitro.
other	35799735	hsa-mir-210	Retinal Vein Occlusion	CONCLUSION: In patients with CRVO combined with macular edema, HIF-1alpha mRNA and miR-210 were highly expressed in the aqueous humor, which may play an important role in the occurrence and development of the disease.
other	35799735	hsa-mir-210	Macular Edema	CONCLUSION: In patients with CRVO combined with macular edema, HIF-1alpha mRNA and miR-210 were highly expressed in the aqueous humor, which may play an important role in the occurrence and development of the disease.
genetics_overexpression_suppress	35799645	hsa-mir-17	Neurotoxicity Syndromes	CONCLUSION: Overexpressed miR
genetics_knock down_suppress	35799601	hsa-mir-29c	Inflammation	For the function of miR-29c-5p in ischemic stroke, the miR-29c-5p knockdown decreased the permeability and the tight junction protein (TJP) destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes.
other	35799072	hsa-mir-187	Carcinoma, Renal Cell	Deciphering the role of miR-187-3p/LRFN1 axis in modulating progression, aerobic glycolysis and immune microenvironment of clear cell renal cell carcinoma.
genetics_knock down_suppress	35798695	hsa-mir-1277	Colorectal Neoplasms	5p was silenced, knockdown of HOTAIR was unable to reduce the oxaliplatin resistance in CRC cells.
other	35798238	hsa-mir-345	Carcinoma, Hepatocellular	Mechanistically, RP11-386G11.10 acted as a competing endogenous RNA (ceRNA) for miR3p to regulate the expression of HNRNPU and its downstream lipogenic enzymes, leading to lipid accumulation in HCC cells and promoting their growth and metastasis.
genetics_overexpression_promote	35797350	hsa-mir-130a	Breast Neoplasms	Overexpression of miR-130a-3p inhibited the expression of NRARP and some Wnt/beta-catenin signaling pathway genes, as well as exerted anti-tumor effects as evidenced by decreased cell proliferation, AIG, and migration of BC cells.
genetics_overexpression_promote	35796939	hsa-mir-17	Stomach Neoplasms	Thus, our data suggest that the overexpression of hsa_circ_0017252 suppresses GC malignancy by sponging miR
genetics_overexpression_promote	35796297	hsa-mir-326	Celiac Disease	Results: Although miR-326 mRNA expression was significantly lower in CD patients (P = 0.001), no significant difference was observed in ETS1 mRNA level between the two groups (P = 0.54), but IL-17A was significantly overexpressed in CD patients (P=0.002).
exosome	35795997	hsa-mir-155	Acute Kidney Injury	Thus, the present study demonstrated that exosomal miR155 mediated the communication between activated macrophages and injured tubules, leading to progression of AKI, which not only provide novel insights into the pathophysiology of AKI but also offer a new therapeutic strategy for kidney diseases.
genetics_overexpression_suppress	35795731	hsa-mir-887	Colorectal Neoplasms	From in vivo experiments, overexpression of miR
lncRNA target	35795552	hsa-mir-98	pancreatic adenocarcinoma	In conclusion, our study suggested that LINC02432/hsa-miR5p/HK2 axis may serve as a novel diagnostic, prognostic, and therapeutic target in PAAD treatment.
lncRNA target	35795482	hsa-mir-520c	Hepatitis B	Moreover, we discovered that HBV promoted EMT via the miR-520c-3p-PTEN to activate AKT-NFkappaB signaling pathway, leading to increased HCC migration and invasion.
other	35795226	hsa-mir-335	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
other	35795226	hsa-mir-1343	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
other	35795226	hsa-mir-495	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
other	35795226	hsa-mir-340	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
other	35795226	hsa-mir-708	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
other	35795226	hsa-mir-630	Pulmonary Fibrosis	Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343).
epigenetics	35795202	hsa-mir-454	Carcinoma, Non-Small-Cell Lung	Therefore, we concluded that promoter hypermethylation of the 4.1N/EPB41L1 gene and abnormally high expressed miR
epigenetics	35795047	hsa-mir-370	Carcinoma, Hepatocellular	Mechanistically, circASPH could regulate the methylation of the promoter and expression of hydrocyanic oxidase 2 (HAO2) to promote HCC progression by acting as a sponge for miR
target gene	35794978	hsa-mir-370	Pancreatic Neoplasms	Deoxyelephantopin Suppresses Pancreatic Cancer Progression In Vitro and In Vivo by Targeting linc00511/miR-370-5p/p21 Promoter Axis.
other	35794963	hsa-mir-92b	Venous Thromboembolism	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
other	35794963	hsa-mir-92b	Colorectal Neoplasms	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
other	35794963	hsa-mir-10	Colorectal Neoplasms	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
other	35794963	hsa-mir-652	Venous Thromboembolism	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
other	35794963	hsa-mir-652	Colorectal Neoplasms	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
other	35794963	hsa-mir-10	Venous Thromboembolism	Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated.
genetics_knock down_suppress	35794743	hsa-mir-99b	Ovarian Neoplasms	It was demonstrated in this study that knockdown of UCA1 inhibited ovarian cancer cell viability, which a miR-99b-3p inhibitor could reverse in vitro. Inhibition of UCA1/miR-99b-3p/SRPK1 axis may become a novel target for treating ovarian cancer.
lncRNA target	35794700	hsa-mir-885	Ovarian Neoplasms	5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques.
lncRNA target	35794700	hsa-let-7d	Ovarian Neoplasms	5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques.
lncRNA target	35794700	hsa-mir-1909	Ovarian Neoplasms	5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques.
transcription factor target	35794619	hsa-mir-32	Diabetes Mellitus, Type 2	CONCLUSIONS: These results reveal that EVs are the key pathway by which macrophages promote T2D VC, and that EVs miR-32 is a key cause of autophagy inhibition in VSMCs.
other	35794555	hsa-mir-139	Breast Neoplasms	And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC.
other	35794555	hsa-mir-375	Breast Neoplasms	And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC.
other	35794450	hsa-mir-576	Breast Neoplasms	3p/SOX4 axis in breast cancer, providing potential and exploitable diagnostic and therapeutic molecules for breast cancer.
genetics_overexpression_promote	35794445	hsa-mir-802	Femur Head Necrosis	Overexpression of TRG-AS1 restrained Dex-induced inhibition of osteogenic differentiation, promoted CAB39/AMPK/SIRT-1 and inhibited NF-kappaB, while overexpression of miR-802 bridled the inhibitory effect of TRG-AS1 on OP.
genetics_overexpression_promote	35794445	hsa-mir-802	Osteoporosis	Overexpression of TRG-AS1 restrained Dex-induced inhibition of osteogenic differentiation, promoted CAB39/AMPK/SIRT-1 and inhibited NF-kappaB, while overexpression of miR-802 bridled the inhibitory effect of TRG-AS1 on OP.
lncRNA target	35794253	hsa-mir-136	Stomach Neoplasms	CONCLUSION: By regulating the PTEN/AKT signaling pathway through competitively binding with hsa-miR5p, hsa_circ_0006282 suppresses the growth of gastric cancer.
circulation_biomarker_prognosis_up	35793786	hsa-mir-1246	Multiple Myeloma	CONCLUSION: This study demonstrates that circulating miR-1246 level is elevated in MM patients, which shows high values in the diagnosis and prognosis prediction in patients with MM.
genetics_GWAS	35793763	hsa-mir-223	Ischemic Stroke	The combined detection of plasma microRNA-223 and cYP2c19 gene polymorphisms may be effective in predicting the occurrence of clopidogrel HTPR in patients with AIS.
genetics_knock down_suppress	35793478	hsa-mir-136	Sepsis	Overall, lncRNA GAS6-AS2 knockdown has the potential to ameliorate sepsis-related AKI, and the mechanism is related to miR5p/OXSR1 axis.
genetics_knock down_suppress	35793478	hsa-mir-136	Acute Kidney Injury	Overall, lncRNA GAS6-AS2 knockdown has the potential to ameliorate sepsis-related AKI, and the mechanism is related to miR5p/OXSR1 axis.
circRNA target	35793013	hsa-mir-24	Glioma	Circ_0079593 triggered glioma development via miR
transcription factor target	35792987	hsa-mir-21	Fibrosis	However, the regulative effect of liraglutide on atrial fibrosis via miR-21 and the underlying mechanism are still unclear.
other	35792987	hsa-mir-21	Atrial Fibrillation	It has been reported that miR-21 modulated cardiac fibrosis in AF.
lncRNA target	35792605	hsa-mir-4458	Breast Neoplasms	In this study, miR-4458 was upregulated in ER+ breast cancer and could inhibit MCF-7 cell viability, colony formation, migration, and invasion. In conclusion, GNs can be potentially used to deliver siRNA or miRNA, and miR-4458 and COL11A1 can be possible targets for ER+ breast cancer treatment.
transcription factor target	35792203	hsa-mir-223	Dmd-Associated Dilated Cardiomyopathy	In summary, miR3p could be a potential therapeutic target for DCM.
other	35792203	hsa-mir-223	Hyperglycemia	The above findings inspired us to propose a new signaling pathway to regulate scoria of cardiomyocytes under hyperglycemia: miR3p upward arrow--> SPI1 downward arrow--> caspase-1 upward arrow --> IL-1beta and other pyroptosis-associated poteins upward arrow--> pyroptosis upward arrow.
transcription factor target	35792203	hsa-mir-223	Necrobiotic Disorders	3p leading to pyroptosis, we found inhibition of miR
genetics_overexpression_promote	35792156	hsa-mir-6071	Carcinoma, Hepatocellular	Further study showed that PTPN11 interference and specific inhibitors IACS-13909 abrogated the discrepancy of self-renewal ability, proliferation, migration and tumorigenicity capacity between miR-6071 overexpression HCC cells and control cells.
circulation_biomarker_prognosis_ns	35792028	hsa-mir-338	Cardiomyopathies	Besides, serum miR
lncRNA target	35791923	hsa-mir-27b	Osteoarthritis, Knee	CONCLUSION: Our findings demonstrate that miR-27b-3p has a key role in ECM regulation associated with synovial fibrosis during OA.
genetics_overexpression_promote	35791807	hsa-mir-200c	Non-alcoholic Fatty Liver Disease	Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR-200c/SIK2/PI3K/Akt axis.
genetics_knock down_suppress	35791576	hsa-mir-153	Hypoxia-Ischemia, Brain	In conclusion, knockdown of SNHG15 alleviated HI brain injury through modulating the miR3p/ SETD7 axis.
lncRNA target	35791460	hsa-mir-758	Cartilage Diseases	Mechanistically, circNFIX acted as a sponge of miR758-3p and played a role in the chondrogenesis and chondrocyte degeneration by targeting the miR3p/KDM6A axis.
exosome	35791342	hsa-mir-142	Retinoblastoma	Growth Inhibition of Retinoblastoma Cell Line by Exosome-Mediated Transfer of miR-142-3p.
other	35791074	hsa-mir-1286	Stomach Neoplasms	CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2. In sum, CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination.
other	35790551	hsa-mir-6720	Bronchopulmonary Dysplasia	Further, 455 circRNA/lncRNA-miRNA-mRNA interaction networks were predicted, including hsa_circ_0086913/hsa-miR-103a-3p/transmembrane 4 L six family member 1 (TM4SF1) and lncRNA-SNHG20/hsa-miR5p/spermine synthase (SMS) networks, which may take part in BPD.
other	35790551	hsa-mir-103a	Bronchopulmonary Dysplasia	Further, 455 circRNA/lncRNA-miRNA-mRNA interaction networks were predicted, including hsa_circ_0086913/hsa-miR-103a-3p/transmembrane 4 L six family member 1 (TM4SF1) and lncRNA-SNHG20/hsa-miR5p/spermine synthase (SMS) networks, which may take part in BPD.
genetics_knock down_promote	35790503	hsa-mir-375	Esophageal Squamous Cell Carcinoma	Furthermore, miR-375 upregulation phenocopied circ_0000654 knockdown in inhibiting ESCC progression. CONCLUSION: Our findings identify a new circ_0000654/miR-375/E2F3 ceRNA crosstalk for the oncogenic role of circ_0000654 in ESCC and establish a notion that targeting circ_0000654 and its pathways may have the potential to improve ESCC outcome.
transcription factor target	35790441	hsa-mir-146a	Glioma	CONCLUSION: AVT can inhibit the proliferation, invasion and migration and promote apoptosis of human glioma cells possibly by up-regulating miR-146a expression and inhibiting the PI3K/Akt signaling pathway.
circulation_biomarker_diagnosis_ns	35790263	hsa-mir-4257	Colorectal Neoplasms	CONCLUSION: miR-4257 level in plasma and cancer tissues is a biomarker of disease recurrence in patients with CRC.
genetics_GWAS	35789992	hsa-mir-205	Squamous Cell Carcinoma of Head and Neck	nucleatum ) impacts HNSCC epigenetic changes in tissues with deficient MMR to promote DNA damage and cell proliferation by suppressing MMRrelated gene expression via the TLR4/MYD88/miR
circulation_biomarker_diagnosis_ns	35789846	hsa-mir-411	Carcinoma, Hepatocellular	5p was decreased in serum exosomes of nonalcoholic steatohepatitis (NASH) patients as compared with that in healthy controls.
lncRNA target	35789750	hsa-mir-200a	COVID-19	Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated.
lncRNA target	35789750	hsa-let-7b	COVID-19	Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated.
lncRNA target	35789750	hsa-let-7b	Mucositis	Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated.
lncRNA target	35789750	hsa-mir-200a	Mucositis	Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated.
genetics_overexpression_promote	35789645	hsa-mir-155	Stomach Neoplasms	5p was overexpressed in gastric cancer cells and clinical tissues, while Res inhibited gastric cancer cell growth by regulating miR
transcription factor target	35789312	hsa-mir-106b	Status Epilepticus	The miRNA miR-106b-5p has been linked to epilepsy, but its specific role and mechanism of action remain unclear. Our results suggest that therapeutic strategies targeting miR-106b-5p or downstream factors can be effective in preventing epileptogenesis or treating epilepsy.
lncRNA target	35789225	hsa-mir-21	Pancreatic Carcinoma	Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy.
genetics_knock down_suppress	35789143	hsa-mir-9	Small Cell Lung Carcinoma	Notably, we found apparent de-repression of common target genes of different miRNAs following ASCL1 knockdown, suggesting combinatorial action of multiple miRNAs underlying molecular heterogeneity of SCLC (e.g., co-targeting of YAP1 by miR-9 and miR-375).
genetics_knock down_suppress	35789143	hsa-mir-375	Small Cell Lung Carcinoma	Notably, we found apparent de-repression of common target genes of different miRNAs following ASCL1 knockdown, suggesting combinatorial action of multiple miRNAs underlying molecular heterogeneity of SCLC (e.g., co-targeting of YAP1 by miR-9 and miR-375).
lncRNA target	35788944	hsa-mir-183	Urinary Bladder Neoplasms	5p modulated not only PNPT1 but also Bcl2 modifying factor (BMF) to inhibit the mitochondrial outer membrane permeabilization (MOMP) in BC cells.
exosome	35788900	hsa-mir-126	Myocardial Infarction	This study demonstrated that animal rat models' combination treatment with microRNA-126 and microRNA-146a mimics in exosomes is desirable for cardiac regeneration after myocardial infarction.
exosome	35788900	hsa-mir-146a	Myocardial Infarction	This study demonstrated that animal rat models' combination treatment with microRNA-126 and microRNA-146a mimics in exosomes is desirable for cardiac regeneration after myocardial infarction.
other	35788691	hsa-mir-146b	Mycosis Fungoides	However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides.
other	35788691	hsa-mir-150	Mycosis Fungoides	However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides.
other	35788691	hsa-mir-142	Mycosis Fungoides	However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides.
lncRNA target	35788362	hsa-mir-491	Stomach Neoplasms	To our knowledge, this is the first study to demonstrate that FOCAD is a tumor suppressor, higher FOCAD levels might be a better prognostic marker of gastric cancer, and FOCAD/miR
lncRNA target	35787669	hsa-mir-614	Breast Neoplasms	In contrast to CFAP20DC-AS1, miR3p was upregulated by Rh2, inhibiting proliferation but stimulating apoptosis of the MCF-7 cells.
lncRNA target	35787628	hsa-mir-1286	Carcinoma, Renal Cell	Taken together, our findings on COL18A1-AS1-miR-1286/KLF12 axis revealed a potential mechanism of abnormal accumulation of lipids in ccRCC and could be a promising therapeutic target for ccRCC patients.
other	35787258	hsa-mir-96	Osteosarcoma	LncRNA NDRG1 aggravates osteosarcoma progression and regulates the PI3K/AKT pathway by sponging miR-96-5p.
genetics_knock down_promote	35786646	hsa-mir-711	Stomach Neoplasms	The knockdown of CD44 showed similar effects as miR-711 overexpression in GC cells.
lncRNA target	35786456	hsa-mir-27a	Reperfusion Injury, Cerebral Ischemia	Objective To investigate the role and molecular mechanism of miR-27a in cerebral ischemia reperfusion injury model in rats. Conclusion In the process of cerebral ischemia and reperfusion, the up-regulated miR-27a may induce ferroptosis through inhibiting SLC7A11, thus causing brain tissue damage.
lncRNA target	35786454	hsa-mir-20	Sepsis	Conclusion LOC102640791 alleviates sepsis inflammatory response by sponging miR5p.
genetics_overexpression_promote	35786451	hsa-mir-151	Stomach Neoplasms	3p in exosomes of tumor cells overexpressing miR
lncRNA target	35786376	hsa-mir-29	Cognitive Dysfunction	CONCLUSIONS: All the results provide evidence for the protective role of TAB against sevoflurane-induced cognitive impairments, which was achieved by alleviating neurotoxicity and neuroinflammation through differentially regulating miR
exosome	35785218	hsa-mir-138	Osteosarcoma	Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma.
exosome	35785218	hsa-mir-1291	Osteosarcoma	Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma.
other	35785160	hsa-mir-9	Breast Neoplasms	Finally, we constructed a lncRNA KCNQ1OT1-LINC00665-TUG1/miR5p/CDH1 regulatory axis of the ceRNA network to explore the mechanism of BRCA progression.
genetics_overexpression_promote	35785045	hsa-mir-16	Osteosarcoma	E2F3 overexpression or miR
other	35785034	hsa-let-7b	Tuberculosis, Pulmonary	CONCLUSION: Our data shows that interleukin-27 and CXCL10 are significantly related in pulmonary tuberculosis, and has-let-7b-5p and has-miR-30a-3p are also related to interleukin-27 and CXCL10.
lncRNA target	35785031	hsa-mir-199a	Cardiomyopathies	miR-199a-3p is thought to be strongly linked with the development of some myocardial diseases, but the influence of miR-199a-3p in MIRI remains unclear. This study might be helpful for the therapeutic method of MIRI through by regulating miR-199a-3p/mTOR.
other	35784838	hsa-mir-486	Tuberous Sclerosis	Meanwhile, we found that the disorder of FGFR3, hsa-miR5p, and lnc-KCNH5-1 plays a key vital role in developing TLE+HS.
other	35784838	hsa-mir-486	Epilepsy, Temporal Lobe	Meanwhile, we found that the disorder of FGFR3, hsa-miR5p, and lnc-KCNH5-1 plays a key vital role in developing TLE+HS.
other	35784724	hsa-mir-92b	Hepatolenticular Degeneration	3p to regulate the expression of genes including Smad9, Mapk10, and Aldh3a2, which may participate in WD-related kidney injury.
epigenetics	35784716	hsa-mir-194	Coronary Artery Disease	Our team found that hypomethylation of miR-194 could be an important mechanism of CAD.
transcription factor target	35784690	hsa-mir-181a	Temporomandibular Joint Disorders	Intra-articular injection of miR-181a-5p antisense oligonucleotide (ASO) could reduce the cartilage damage and alleviate UAC-induced TMJOA progression, but it did not restore injured subchondral bone.
transcription factor target	35784690	hsa-mir-181a	Cartilage Diseases	Intra-articular injection of miR-181a-5p antisense oligonucleotide (ASO) could reduce the cartilage damage and alleviate UAC-induced TMJOA progression, but it did not restore injured subchondral bone.
other	35784469	hsa-mir-205	Shock, Septic	Moreover, enrichment of triplex-forming sequences was found upstream of MIR205HG/LEADR-bound genes, peaking at -1,500/-500 bp from TSS.
other	35784175	hsa-mir-299	Intervertebral Disc Degeneration	CONCLUSION: The SNHG5/miR5p/ATF2 can be used as biomarker of IDD, and infiltration of immune cells plays an important role in the pathological development of IDD.
circulation_biomarker_diagnosis_down	35783838	hsa-mir-181a	ST Elevation Myocardial Infarction	CONCLUSION: Circulating exosome miR
other	35783531	hsa-mir-192	Pneumonia	CONCLUSION: miR-223 and miR-192 can reflect coagulation function in children with SP, which can provide a certain reference basis for clinical guidance and treatment and prognosis.
other	35783531	hsa-mir-223	Pneumonia	CONCLUSION: miR-223 and miR-192 can reflect coagulation function in children with SP, which can provide a certain reference basis for clinical guidance and treatment and prognosis.
circulation_biomarker_diagnosis_ns	35783530	hsa-mir-411	Lymphoma, Large B-Cell, Diffuse	5p bound to LINC00461 and BNIP3 and was negatively correlated with LINC00461 and BNIP3 mRNA in blood of DLBCL patients.
genetics_knock down_promote	35783190	hsa-mir-376a	Osteosarcoma	Furthermore, knockdown of miR-376a reversed the influences of MALAT1 silencing in osteosarcoma cells.
target gene	35783157	hsa-mir-205	Uterine Cervical Neoplasms	LncRNA FAM13A-AS1 Regulates Proliferation and Apoptosis of Cervical Cancer Cells by Targeting miRNA-205-3p/DDI2 Axis.
lncRNA target	35783150	hsa-mir-5195	Pituitary Neoplasms	ST8SIA6-AS1 targets miR
target gene	35783137	hsa-mir-26a	Alzheimer Disease	PTGS2 can be used as a target for AD research, and miR-26a-5p/PTGS2 can be used as an axis of action to study the pathogenesis of AD
lncRNA target	35783018	hsa-mir-136	Pneumonia, Mycoplasma	More results indicated that high expression of miR-136 and low expression of N-cadherin appeared in PE. In terms of mechanism, circ_0055724 may induce the expression of N-cadherin and regulate the proliferation, migration, and invasion of trophoblast cells through decreasing miR-136, which can be a promising biomarker for early diagnosis and prognosis of patients with PE.
lncRNA target	35783017	hsa-mir-802	Colonic Neoplasms	CONCLUSION: circIFITM1 facilitates the proliferative and invasive abilities via miR-802/FOXP1 in Lovo cells.
other	35783013	hsa-mir-142	Colorectal Neoplasms	In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of beta-catenin and activation Wnt/beta-catenin pathway.
other	35783013	hsa-mir-634	Colorectal Neoplasms	In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of beta-catenin and activation Wnt/beta-catenin pathway.
circulation_biomarker_diagnosis_up	35782940	hsa-mir-27a	Obesity	The level of serum exosomal miR-27a in the non-exercise obese group was increased obviously, which was reduced in the exercise obese groups.
target gene	35782903	hsa-let-7c	Leukemia	miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages.
circulation_biomarker_diagnosis_up	35782895	hsa-mir-126	Breast Neoplasms	Notably, circulating miR-126 level was decreased in the BC and OC groups, but not in the CF group.
transcription factor target	35782645	hsa-mir-21	Acute Lung Injury	Therefore, this study was performed to examine the possible implication of NLRP3 inflammasome and miRNA-21 in the pathogenesis of the MTX-induced lung injury as well as the protective role of GB in ameliorating the induced lung injury. This study is the first report to reveal the involvement of NLRP3 inflammasome in the pathogenesis of MTX-induced lung injury and also to show that the administration of GB alleviates the lung injury induced by MTX via suppressing the oxidative stress, restoring the antioxidant activity, blocking the NLRP3/ASC/Caspase-1 signaling and downregulating the NF-kBp65 protein expression ae well as miRNA-21 expression in lung tissue.
genetics_overexpression_promote	35782228	hsa-mir-181c	Cartilage Diseases	Also, overexpression of SMAD7 inhibited the repairing effect of BMP2, and overexpression of BMP2 and miR-181c-5p further promoted the repair of cartilage injury in vivo.
lncRNA target	35782084	hsa-mir-1	Retinoblastoma	CONCLUSION: lncRNA FOXD2-AS1 inhibited cell proliferation and migration via the miRNA-31/PAX9 axis in retinoblastoma.
lncRNA target	35782062	hsa-mir-339	Glioma	5p in glioma can regulate the proliferative, apoptotic, invasive, and migratory abilities of glioma U87 cells and might suppress the occurrence and development of glioma.
circulation_biomarker_diagnosis_up	35781746	hsa-mir-146a	Sepsis	In this study, the miR-146a-5p level was elevated in the serum of sepsis patients and LPS-induced DCs but decreased in the serums of cured sepsis patients.
genetics_knock down_promote	35781593	hsa-mir-135b	Parkinson Disease	Besides, miR-135b-5p interacted with the 3' untranslated region (3'UTR) of KPNA4, and KPNA4 overexpression partly reversed miR-135b-5p overexpression-induced effects in PD cell model.
lncRNA target	35781592	hsa-mir-21	Cognition Disorders	Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus.
lncRNA target	35781592	hsa-mir-21	Diabetes Mellitus, Type 2	Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus.
other	35781287	hsa-mir-206	Cognition Disorders	In this study, we aimed to elucidate the role of hUCMSCs with down-regulated miRNA-206 (hUCMSCs anti-miR-206) on cognitive decline and the underlying mechanism.
transcription factor target	35781221	hsa-mir-26a	Cognition Disorders	Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified.
transcription factor target	35781221	hsa-mir-203a	Cognition Disorders	Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified.
transcription factor target	35781221	hsa-mir-155	Cognition Disorders	Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified.
other	35781028	hsa-mir-155	Intervertebral Disc Degeneration	Moreover, downregulation of total ERK1/2 in hASCs and oNP cells, after miR-155 LNC treatment, was demonstrated by Western blot and quantitative reverse-transcription PCR (qRT-PCR), thus confirming maintenance of its bioactivity after formulation and internalization.
other	35780970	hsa-mir-28	Down Syndrome	Among those, miR5p and let-7d-5p were found significantly decreased in physiological ageing ( oldest group ), thus they emerged as possible biomarkers of premature ageing in DS.
other	35780970	hsa-let-7d	Down Syndrome	Among those, miR5p and let-7d-5p were found significantly decreased in physiological ageing ( oldest group ), thus they emerged as possible biomarkers of premature ageing in DS.
circulation_biomarker_diagnosis_ns	35780970	hsa-mir-628	Down Syndrome	Moreover, measuring blood levels of beta amyloid peptides, Abeta-42 was assessed at the lowest levels in physiological ageing and correlated with miR
other	35780710	hsa-mir-34c	Influenza, Human	CONCLUSION: Our data elucidated that UA attenuated IAV-triggered inflammatory responses and oxidative stress in A549 cells by regulating the miR-34c-5p/TLR5 axis, suggesting that UA plays a protective role in IAV-induced pneumonia.
lncRNA target	35780585	hsa-mir-222	Leukemia, Myeloid, Acute	3p increased the viability and suppressed the apoptosis of AML cells.
transcription factor target	35780573	hsa-mir-1306	Leukemia, Myeloid, Acute	5p may function as an oncogene in AML, providing a promising therapeutic target for AML patients.
circulation_biomarker_diagnosis_up	35779817	hsa-mir-101	Ischemic Stroke	3p was downregulated in the plasma of patients with IS but upregulated in the patients with neurological recovery after rt-PA intravenous thrombolysis.
circulation_biomarker_diagnosis_up	35779817	hsa-mir-101a	Ischemic Stroke	3p was downregulated in the plasma of patients with IS but upregulated in the patients with neurological recovery after rt-PA intravenous thrombolysis.
lncRNA target	35779785	hsa-mir-140	Tuberculosis	CONCLUSION: The present results suggested that SNHG16 may be a new diagnostic biomarker for TB patients and SNHG16 silencing may alleviate TB by inhibiting the proliferation of macrophages in TB by regulation miR
genetics_overexpression_suppress	35779698	hsa-mir-214	Dry Eye Syndromes	Furthermore, KCNQ1OT1 knockdown and miR-214 overexpression reversed the effect of HS, promoted the migration of HCECs, and accelerated corneal wound healing.
other	35779530	hsa-mir-370	Uterine Cervical Neoplasms	In conclusion, this research premise identified the biological function of circEPSTI1-miR3p-MSH2 axis in cervical cancer progression.
target gene	35779335	hsa-mir-590	Encephalitis Virus, Japanese	miR-590-3p could directly target the expression levels of USP42 (Ubiquitin Specific Peptidase 42) resulting in increased cellular levels of USP42 upon JEV infection.
target gene	35779228	hsa-mir-134-2p	Breast Neoplasms	Reporter assays proved direct binding of miR-134-3p and miR-224-3p to the SOX9 3'-UTR in MDA-MB-231 and MCF-7 cells.
target gene	35779228	hsa-mir-224	Breast Neoplasms	Reporter assays proved direct binding of miR-134-3p and miR-224-3p to the SOX9 3'-UTR in MDA-MB-231 and MCF-7 cells.
target gene	35779228	hsa-mir-6859	Breast Neoplasms	Transfection of miR-134-3p, miR-224-3p, or miR-6859-3p reduced SOX9 expression on mRNA and protein level.
other	35779226	hsa-mir-146	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-7b	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-586	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-3596d	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-26a	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-1249	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-mir-328a	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
other	35779226	hsa-let-7i	Diabetic Cardiomyopathies	3p, miR-26a-3p) in diabetes-induced cardiac cells.
lncRNA target	35778962	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Circ_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR
circRNA target	35778952	hsa-mir-145	Diabetes Mellitus, Type 2	This study thus showed that hsa_circ_0115355 inhibits the occurrence and development of T2DM by regulating the expression of SIRT1 by adsorbing miR-145.
target gene	35778917	hsa-mir-363	T-cell acute lymphoblastic leukemia	we show that miR-363-3p enhances cell growth of T-ALL in vitro via inhibition of PTPRC and SOCS2, which are implicated in repression of the JAK-STAT pathway.
other	35778809	hsa-mir-200a	Erectile Dysfunction	In this study, aged rats were divided into AE group (aged rats with ED) and YN group (young normal rats) for evaluating the roles of miRNA-200a and RhoA/ROCK signalling pathway in A-ED.
genetics_overexpression_suppress	35778755	hsa-mir-874	Nasopharyngeal Carcinoma	Overexpression of miR-874-3p prevented cell growth, motility, glucose consumption, and lactate production in NPC cells, whereas miR-874-3p inhibition had the opposite effects.
target gene	35778656	hsa-mir-1307	Urinary Bladder Neoplasms	miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway.
other	35778654	hsa-mir-19b	Heart Defects, Congenital	RNA-seq profiling and dual-luciferase reporter assay revealed that NKX2-5 acts upstream of PYK2 via miR-19a and miR-19b (miR-19a/b) to regulate cardiomyocyte apoptosis.
other	35778654	hsa-mir-19a	Heart Defects, Congenital	RNA-seq profiling and dual-luciferase reporter assay revealed that NKX2-5 acts upstream of PYK2 via miR-19a and miR-19b (miR-19a/b) to regulate cardiomyocyte apoptosis.
lncRNA target	35778646	hsa-mir-204	Esophageal Squamous Cell Carcinoma	We further confirmed that FOXD2-AS1 was the upstream inhibitor of miR-204-3p and the down-regulation of miR-204-3p reversed the repressive effects of low expression of FOXD2-AS1 on ESCC progression.
lncRNA target	35778520	hsa-mir-10	Carcinoma, Hepatocellular	Moreover, we conduct upstream miRNAs and lncRNAs of TOP2A to establish ceRNA networks in kidney renal clear cell carcinoma (SNHG3-miR-139-5p), kidney renal papillary cell carcinoma (TMEM147-AS1/N4BP2L2-IT2/THUMPD3-AS1/ERICD/TTN-AS1 liver hepatocellular carcinoma (SNHG3/THUMPD3-AS1/NUTM2B-AS1/NUTM2A-AS1-miR-139-5 and SNHG6/GSEC/SNHG1/SNHG14/LINC00265/MIR3142HG-miR-10 and lung adenocarcinoma (TYMSOS/HELLPAR/SNHG1/GSEC/SNHG6-miR-101-3p).
lncRNA target	35778520	hsa-mir-101	Adenocarcinoma of Lung	Moreover, we conduct upstream miRNAs and lncRNAs of TOP2A to establish ceRNA networks in kidney renal clear cell carcinoma (SNHG3-miR-139-5p), kidney renal papillary cell carcinoma (TMEM147-AS1/N4BP2L2-IT2/THUMPD3-AS1/ERICD/TTN-AS1 liver hepatocellular carcinoma (SNHG3/THUMPD3-AS1/NUTM2B-AS1/NUTM2A-AS1-miR-139-5 and SNHG6/GSEC/SNHG1/SNHG14/LINC00265/MIR3142HG-miR-10 and lung adenocarcinoma (TYMSOS/HELLPAR/SNHG1/GSEC/SNHG6-miR-101-3p).
other	35777901	hsa-mir-155	Hypoxia	METHODS: Immunostaining, western blot and quantitative real-time reverse transcription PCR (qRT-PCR) were performed to detect the expression of glucose transporter 5 (GLUT5), ketohexokinase (KHK)-A and KHK-C in miR-155(-/-) and miR-155(wt) CFs under normoxia or hypoxia. RESULTS: When both miR-155(-/-) and miR-155(wt) CFs were exposed to hypoxia for 24 h, these two cells exhibited an increased glycolysis and decreased glycogen synthesis, and the expression of KHK-A and KHK-C, the central fructose-metabolizing enzyme, was upregulated.
lncRNA target	35777805	hsa-mir-497	Thyroid Cancer, Papillary	Our findings demonstrated that down-regulation of CERS6-AS1 reduced cell viability and amplified cell ferroptosis by modulating the miR-497-5p/LASP1 axis in papillary thyroid cancer.
target gene	35777802	hsa-mir-146a	Pancreatitis	Luciferase assay confirmed miR-146a-5p can directly target IRAK1 and TRAF6. Overexpression of miR-146a-5p ameliorates inflammation and autophagy in TLCs-treated AR42J cells by inhibiting IRAK1/ TRAF6/NF-kappaB pathway.
epigenetics	35777791	hsa-mir-186	Endometrial Neoplasms	CONCLUSION: Therefore, circSEPT9 is upregulated in EC and promotes cell invasion and migration by downregulating miR-186 through methylation.
genetics_overexpression_promote	35777757	hsa-mir-200c	Cardiomegaly	these effects then led to reduced binding of GAS5 to miR-495-3p, increased miR-495-3p expression, and repression of PHF8 transcription. Through these mechanisms, our data indicate that KDM3C-dependent epigenetic modification promotes CH.
target gene	35777757	hsa-mir-495	Cardiomegaly	KDM3C upregulated miR-200c-3p expression through demethylation of H3K9me2, leading to enhanced binding of miR-200c-3p to GAS5 and suppression of GAS5 expression; these effects then led to reduced binding of GAS5 to miR-495-3p, increased miR-495-3p expression, and repression of PHF8 transcription.
target gene	35777302	hsa-mir-25	Osteoporosis	miR-25-3p targets ITGB3, thereby suppressing osteogenic differentiation of BMSCs from OP patients.
circRNA target	35777132	hsa-mir-497	Prostatic Neoplasms	CircPDHX stimulated PCa development via miR-497-5p/ACSL1, which presented a new thought for PCa treatment.
transcription factor target	35776536	hsa-mir-210	Hypoxia	KEY RESULTS: Hypoxia increased mtROS and suppressed mitochondrial respiration in uterine arteries, which were also produced by miR-210 mimic to normoxic arteries and blocked by antagomir miRLNA in hypoxic arteries.
circRNA target	35776379	hsa-mir-1229	Glioblastoma	Moreover, miR-1229-3p could be targeted by circVPS18; inhibition of miR-1229-3p could invert the suppressive effect of circVPS18 knockdown on glioblastoma tumorigenesis.
lncRNA target	35776288	hsa-mir-629	Aortic Valve Disease	3p targeting TAGLN, validating that it is a potential therapeutic target for inhibiting CAVD.
other	35776220	hsa-let-7e	Thyroid Neoplasms	Elevated LINC00894 relieves the oncogenic properties of thyroid cancer cell by sponging let-7e-5p to promote TIA-1 expression.
circRNA target	35775884	hsa-mir-1182	Carcinoma, Hepatocellular	Silencing circ_0061395 inhibited the malignant behavior of HCC cells by releasing miR-1182. Circ_0061395 induced the changes of the expression of SPOCK1 by regulating miR-1182, thereby mediating the process of HCC, and at least partially promoting the development of HCC cells, providing a novel targeted therapy for HCC.
circulation_biomarker_diagnosis_down	35775826	hsa-mir-212	Atherosclerosis	As a result, DLEU2 and YWHAZ were up-regulated, and miR-212-5p was down-regulated in atherosclerosis serum.
circulation_biomarker_diagnosis_down	35775783	hsa-mir-141	Prostatic Neoplasms	The level of miR141 was significantly lower in PCa cases than healthy individuals (p=0,004), and miR155 was significantly higher (p=0,005) in PCa cases.
other	35775783	hsa-mir-125b	Prostatic Neoplasms	Tumor mass were found to be associated with the level of miR-125b and miR-145.
circulation_biomarker_diagnosis_up	35775783	hsa-mir-155	Prostatic Neoplasms	The level of miR141 was significantly lower in PCa cases than healthy individuals (p=0,004), and miR155 was significantly higher (p=0,005) in PCa cases.
other	35775783	hsa-mir-145	Prostatic Neoplasms	Tumor mass were found to be associated with the level of miR-125b and miR-145.
tissue_expression_up	35775773	hsa-mir-126	Heart Failure	Results Dramatic increase of ICAM-1 level in activated PBMCs of CHF patients, as well as an increase of the IL-10, ICAM-1 and TNF-alpha levels in the culture medium was observed. It was accompanied by CHF-related miRNA-126 overexpression in PBMCs.
other	35775701	hsa-mir-638	Breast Neoplasms	Alterations in miR-638 may be used with 5-FU chemotherapy during NAC for BC.
other	35774792	hsa-mir-146a	Multiple Sclerosis	We found an association between miR.146a.5p (r(s):0.434, p=0.03) and miR.9.5p (r(s):0.516, p=0.028) with EDSS;
other	35774792	hsa-mir-9	Multiple Sclerosis	We found an association between miR.146a.5p (r(s):0.434, p=0.03) and miR.9.5p (r(s):0.516, p=0.028) with EDSS; Regarding to the brain volume, miR.9.5p correlated with thalamus (r(s):-0.545,
other	35774792	hsa-mir-223	Multiple Sclerosis	and miR-223.3p with caudate (r(s):0.46, p=0.04).
other	35774792	hsa-mir-126	Multiple Sclerosis	and miR-146a.5p (r(s):-0.476, p=0.016) and miR-126.3p (r(s):-0.528, p=0.007) with SDMT.
other	35774792	hsa-mir-138	Multiple Sclerosis	miR-138.5p with amygdala (r(s):0.73, p=0.016) and pallidum (r(s):0.64, p=0.048);
other	35774792	hsa-mir-200c	Multiple Sclerosis	miR.200c.3p with pallidum (r(s):-0.68, p=0.002) and cerebellum (r(s):-0.472, p=0.048);
other	35774498	hsa-mir-4488	Precursor Cell Lymphoblastic Leukemia-Lymphoma	In AML, hsa-miR-4516 and hsa-miR-4488 correlated positively with HLA-G5 mRNA, but the HLA-G5 negatively correlated with sHLA-G.
other	35774498	hsa-mir-5096	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The hsa-miR-4488 and hsa-miR-5096 expression levels were lower in B-ALL than in AML, while that of hsa-miR5p was lower in T-ALL than in AML.
other	35774498	hsa-mir-486	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The hsa-miR-4488 and hsa-miR-5096 expression levels were lower in B-ALL than in AML, while that of hsa-miR5p was lower in T-ALL than in AML.
circulation_biomarker_diagnosis_up	35774277	hsa-mir-222	Mycoplasma pneumoniae pneumonia	We found that, compared to normal, MPP patients exhibited a significant up-regulated miR-222-3p.
other	35773744	hsa-mir-133b	Colorectal Neoplasms	CONCLUSIONS: Our findings not only reveal the pivotal roles of circEZH2 in modulating CRC progression, but also advocate for attenuating circEZH2/miR-133b/IGF2BP2/ CREB1 regulatory axis to combat CRC.
lncRNA target	35773374	hsa-mir-656	Colorectal Neoplasms	Therefore, RPL34-AS1 is downregulated in CRC and may sponge miR-3656 to suppress cell proliferation in CRC.
genetics_GWAS	35772782	hsa-mir-885	COVID-19	Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum.
genetics_GWAS	35772782	hsa-mir-145	COVID-19	Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum.
genetics_GWAS	35772782	hsa-mir-145	Thrombosis	Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum.
genetics_GWAS	35772782	hsa-mir-885	Thrombosis	Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum.
transcription factor target	35772682	hsa-mir-1184	Cardiomyopathies	Moreover, miR-1184 inhibited the H(2)O(2)-induced myocardial injury by targeting RIPK1.
transcription factor target	35772657	hsa-mir-34c	Femur Head Necrosis	Our results underline the critical importance of the miR-34c-5p/MDM4 pathway in regulating the adipogenic outcome of BMSCs, suggesting the miR-34c-5p as a potentially effective therapeutic target in SONFH.
lncRNA target	35772605	hsa-mir-661	Glioma	Moreover, siMdm2 reversed the effects of miR-661 inhibitor on the biological characteristics and Mdm2/p53/p21 expression of glioma cells.
genetics_knock down_promote	35772185	hsa-mir-127	Neuroblastoma	5p counteracted the inhibitory impact of circ_0135889 knockdown on the malignant behaviors of NB cells.
genetics_overexpression_promote	35771766	hsa-mir-4516	Vitreoretinopathy, Proliferative	MiR-4516 suppressed experimental PVR in vitro and in vivo. In conclusion, the overexpression of miR-4516 suppresses TGF-beta2-induced EMT in a PVR model, and its role in PVR depends on OTX1/ERK.
circRNA target	35771357	hsa-mir-11181	Carcinoma, Pancreatic Ductal	CONCLUSIONS: In conclusion, circ-0047078 plays a role in promoting PDAC via miR-11181 and then via CXCL12, MCAM and RGS16.
other	35771149	hsa-mir-613	Stomach Neoplasms	VEGFA served as an important effector for the NUTM2A-AS1/miRregulated resistance of GC cells to matrine.
lncRNA target	35770722	hsa-let-7c	Breast Neoplasms	In particular, let-7c-5p is designated as a tumor suppressor in breast cancer. Taken together, our study demonstrated WA-mediated miRNA expression, in particular, upregulation of miR-let-7c-5p, leads to the inhibition of breast cancer cells derived mammospheres.
other	35770405	hsa-mir-1	Insulin Resistance	Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes.
other	35770405	hsa-mir-1	Obesity	Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes.
other	35770405	hsa-mir-1	Diabetes Mellitus, Type 2	Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes.
genetics_GWAS	35770306	hsa-mir-196a-2	Myotonic Disorders	Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05).
lncRNA target	35770296	hsa-mir-603	Ovarian Neoplasms	DNMT3A was found to promote the Warburg effect, cell proliferation, migration, and invasion of ovarian cancer by inhibiting the expression of miR-603.
circulation_biomarker_diagnosis_ns	35769889	hsa-mir-122	Non-alcoholic Fatty Liver Disease	Our case-control study was to address the value of circulating miRNA-122 and serum pro-neurotensin as a potential non-invasive biomarker for the diagnosis of non-alcoholic fatty acid diseases.
lncRNA target	35769676	hsa-mir-205	Glioma	In conclusion, HCP5 silencing suppressed glioma progression through the HCP5-miR
genetics_knock down_suppress	35769514	hsa-mir-940	Carcinoma, Hepatocellular	downregulated expression was also found in HCC patients, and importantly, miR-940 inhibition reversed circACTG1 expression in 97H cells with circACTG1 knockdown.
lncRNA target	35769097	hsa-mir-206	Non-alcoholic Fatty Liver Disease	MALAT1 regulated PPARalpha/CD36 -mediated hepatic lipid accumulation in NAFLD through regulation of miR-206/ARNT axis. Thus, MALAT1/miR-206/ARNT might serve as a therapeutic target against NAFLD.
lncRNA target	35769053	hsa-mir-29a	Osteonecrosis	CONCLUSIONS: MiR-29a-3p can modulate FOXO3 expression and Wnt/beta-catenin signaling to inhibit viability and osteogenic differentiation of hBMSCs, thereby promoting the development of steroid-associated osteonecrosis.
lncRNA target	35768865	hsa-mir-96	Ovarian Neoplasms	CONCLUSIONS: Our findings indicate that circFBXO7 acts as a bone fide tumor suppressor in ovarian cancer and that the circFBXO7/miR5p/MTSS1 axis is an important regulator in the Wnt/beta-catenin signaling pathway which may provide a promising target for ovarian cancer therapy.
genetics_GWAS	35767710	hsa-mir-21	Myocardial Infarction	In this study, we systematically reviewed the results of published papers on the therapeutic effect of miR-21 for myocardial infarction. This review provides insights into the future advancement of safe miR-21 -based genetic therapy in the treatment of myocardial infarction.
transcription factor target	35767307	hsa-mir-150	Colorectal Neoplasms	In vivo and in vitro studies showed that the viability and invasion of CRC cells were both significantly suppressed by ExomiR-150.
transcription factor target	35767105	hsa-mir-19b	Lung Neoplasms	Among them, miR-19a/b exerts an oncogenic effect by suppressing tumor suppressor genes, including PTEN and TP53INP1in numerous types of cancers, including NSCLC.
transcription factor target	35767105	hsa-mir-19a	Lung Neoplasms	Among them, miR-19a/b exerts an oncogenic effect by suppressing tumor suppressor genes, including PTEN and TP53INP1in numerous types of cancers, including NSCLC.
genetics_knock down_promote	35766911	hsa-mir-136	Osteochondritis Dissecans	CONCLUSION: Circ_TLK1 knockdown ameliorated OGD/R-induced PC12 cell injury by modulating miR
lncRNA target	35766445	hsa-mir-145	Colorectal Neoplasms	5p was disclosed to block CRC via overturning MACC1.
lncRNA target	35765992	hsa-mir-143	Cardiomegaly	Inhibition of miRNA
transcription factor target	35765958	hsa-mir-652	Carcinoma, Non-Small-Cell Lung	3p-inhibitor to explore the role of PTEN ubiquitination and miR
lncRNA target	35765903	hsa-mir-222	Stomach Neoplasms	Our study demonstrates that EZH2 promotes GC development via the modulation of miR
other	35765893	hsa-mir-140	Adrenocortical Carcinoma	3p in ACC progress.
lncRNA target	35765408	hsa-mir-338	Leukemia, Myeloid, Acute	CONCLUSION: Casticin promotes AML cell apoptosis but inhibits AML cell proliferation in vitro and tumor growth in vivo by upregulating miR
genetics_overexpression_promote	35765282	hsa-mir-4735	Stomach Neoplasms	3p overexpression suppressed cell migration and invasion of GC cells, which were antagonized by overexpression of NEDD9.
target gene	35765275	hsa-mir-487a	Osteosarcoma	KLF5-induced miR-487a augments the progression of osteosarcoma cells by targeting NKX3-1 in vitro.
other	35765274	hsa-mir-21	Lung Neoplasms	Nicotine-induced miR-21-3p promotes chemoresistance in lung cancer by negatively regulating FOXO3a.
target gene	35765271	hsa-mir-409	Ovarian Neoplasms	MicroRNA-409-5p inhibits cell proliferation, and induces G(2)/M phase arrest and apoptosis by targeting DLGAP5 in ovarian cancer cells.
genetics_GWAS	35764886	hsa-mir-142	Myeloproliferative Disorders	To extend knowledge about the occurrence of MIR142 mutations, we sequenced the gene in a large panel of MPNs [~ 700 samples, including polycythemia vera, essential thrombocythemia, primary myelofibrosis (PMF), and chronic myeloid leukemia], neoplasm types in which such mutations have never been tested, and in panels of acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL). In summary, mutations in MIR142 are rare in MPNs; however, in specific subtypes, such as PMF, their frequency may be comparable to that observed in CLL or AML.
genetics_GWAS	35764155	hsa-mir-93	Urinary Bladder Neoplasms	This study also shows that the combination of genetic markers (PON1 and CYP17A1) and miRNA (miR
circulation_biomarker_diagnosis_ns	35764071	hsa-mir-146a	Arthritis, Rheumatoid	CONCLUSIONS: These results suggested that miR-146a may be used as a disease progression marker in the peripheral blood of elder RA patients.
other	35764065	hsa-mir-197	Osteoporosis-pseudoglioma syndrome	Circ_0062582 and SMAD5 were downregulated and miR3p was upregulated in OP patients and increased in osteoblast medium (OM)-induced hBMSCs in vitro.
other	35764020	hsa-mir-146a	Urinary Retention	Then, the in vitro effect of miR-146a-5p on the M1/M2 polarization and the secretion of inflammatory cytokines was investigated in Tamm-Horsfall protein-1 (THP-1)-induced macrophages.
lncRNA target	35764020	hsa-mir-146a	Cryopyrin-Associated Periodic Syndromes	In conclusion, miR-146a-5p enhances embryo survival in URSA by promoting decidual macrophage polarization toward an M2 phenotype, giving new ideas and potential targets for subsequent research on the pathogenesis and immunotherapeutic strategies of URSA.
circulation_biomarker_prognosis_up	35763793	hsa-mir-375	Respiratory Distress Syndrome, Newborn	CONCLUSION: Umbilical cord serum miR-375 is elevated and associated with NRDS onset and clinical outcomes in NRDS neonates.
other	35763386	hsa-mir-1207	Colonic Neoplasms	5p level and enhancing the Wnt6/beta-catenin2 pathway.
other	35763314	hsa-mir-484	Leukemia, Myeloid, Acute	We identified new multiomics molecular signatures of relevance to AML: miRNAs (e.g., mir-484 and miR-519d-3p), receptors (ACVR1 and PTPRG), transcription factors (PRDM14 and GATA3), and metabolites (in particular, amino acid derivatives).
other	35763314	hsa-mir-519d	Leukemia, Myeloid, Acute	We identified new multiomics molecular signatures of relevance to AML: miRNAs (e.g., mir-484 and miR-519d-3p), receptors (ACVR1 and PTPRG), transcription factors (PRDM14 and GATA3), and metabolites (in particular, amino acid derivatives).
circRNA target	35763173	hsa-mir-516b	Glioma	In addition, IFI30 was a direct target of miR-516b-5p, and miR-516b-5p inhibited glioma cell malignant behaviors by targeting IFI30 in propofol-treated cells.
genetics_overexpression_promote	35762276	hsa-mir-196a	Carcinoma, Hepatocellular	Overexpressed miR
genetics_overexpression_promote	35762276	hsa-mir-370	Carcinoma, Hepatocellular	Overexpressed miR
lncRNA target	35762105	hsa-mir-219	Glioblastoma	Given the tumour suppressing function of miR-219, and advantage of CS-NPs for gene delivery to the central nervous system, the presented NPs have a great potential for treatment of GBM.
other	35761975	hsa-mir-409	Prostatic Neoplasms	3p, and VEGF scales can provide reference value for clinical guidance of prostate carcinoma prognosis.
other	35761975	hsa-mir-23	Prostatic Neoplasms	3p, and VEGF scales can provide reference value for clinical guidance of prostate carcinoma prognosis.
circulation_biomarker_diagnosis_up	35761942	hsa-mir-204	Endometrial Neoplasms	5p expression is associated with lymph node metastasis in these SLN(+) EC tissues, indicating that the downregulation of serum miR
exosome	35761836	hsa-mir-146a	Diabetic Retinopathy	Our study demonstrated that BMSC exosomal miR-146a can regulate the inflammatory response of DR by mediating the TLR4/MyD88/NF-kappaB pathway, providing an experimental basis for the prevention and treatment of DR.
exosome	35761836	hsa-mir-146a	Inflammation	Our study demonstrated that BMSC exosomal miR-146a can regulate the inflammatory response of DR by mediating the TLR4/MyD88/NF-kappaB pathway, providing an experimental basis for the prevention and treatment of DR.
other	35761801	hsa-mir-124	Vitreoretinopathy, Proliferative	Collectively, these findings suggest that miR-124/LIN7C can modulate EMT and cell migration in RPE cells, which may have therapeutic implications in the management of PVR diseases.
other	35761801	hsa-mir-124	Retinal Neovascularization	Collectively, these findings suggest that miR-124/LIN7C can modulate EMT and cell migration in RPE cells, which may have therapeutic implications in the management of PVR diseases.
lncRNA target	35761386	hsa-mir-124	Osteosarcoma	CONCLUSION: EBF1 induced-FGA5-AS1 aggravated osteosarcoma cell malignancy by targeting miR
genetics_overexpression_promote	35761379	hsa-mir-493	Leukemia, Myeloid, Acute	5p reversed the effects of overexpressed MEG3 on AML cells.
exosome	35761332	hsa-mir-29b	Muscular Atrophy	In our previous study, repressing miR-29b has been shown to reduce muscle atrophy. Our work demonstrates an engineered extracellular vesicles delivery of the miR-29b editing system, which could be potentially used for muscle atrophy therapy.
lncRNA target	35761326	hsa-mir-346	Leishmaniasis	According to our results, the cfa-miR-346 appears to be linked to infection, and understanding its role and identifying its target genes could contribute to elucidate the mechanisms underlying the host-pathogen interaction in leishmaniasis.
lncRNA target	35761309	hsa-mir-144	Diabetes Mellitus, Type 2	CONCLUSION: The up-regulation of miR3p suppressed USP22/SIRT1 to induce ferroptosis, which causes pancreatic beta cells dysfunction, thereby promoting T2DM development.
genetics_knock down_promote	35761154	hsa-mir-21	Laryngeal Neoplasms	5p knockdown in developing laryngeal carcinoma cells.
other	35761105	hsa-mir-29	Diabetes Mellitus, Type 2	MiR-29 (P=0.001) changed significantly in the DD group compared to the control group.
other	35761105	hsa-mir-146a	Diabetes Mellitus, Type 2	MiR-146a changed significantly (P=0.006) in both SD and DD groups compared to the control group.
lncRNA target	35760798	hsa-mir-20b	Carcinoma, Hepatocellular	The results indicated that the deficiency of miR-15a and miR-20b contributed to sorafenib resistance, whereas exogenous expression of miR-15a and miR-20b enhanced sorafenib sensitivity of HCC cells by cell viability, colony formation, and flow cytometry analyses. Taken together, our findings reveal crucial roles of miR-15a, miR-20b, CDC37L1, and PPIA in sorafenib response of HCC cells.
genetics_overexpression_promote	35760009	hsa-mir-200a	Prostatic Neoplasms	Remarkably, colony formation and cell migration were suppressed while cell cycle arrest and apoptosis were induced in prostate cancer cells overexpressing miR-200a and miR-320a. miR-200a and miR-320a were found to be upregulated in TP73-AS1 suppressed prostate cancer cells.
genetics_overexpression_promote	35760009	hsa-mir-20a	Prostatic Neoplasms	Remarkably, colony formation and cell migration were suppressed while cell cycle arrest and apoptosis were induced in prostate cancer cells overexpressing miR-200a and miR-320a. miR-200a and miR-320a were found to be upregulated in TP73-AS1 suppressed prostate cancer cells.
other	35759812	hsa-mir-146a	Inflammation	We aimed to explore how microRNA(miR)-146a, a negative regulator of inflammation, influences osteogenesis in DO.
lncRNA target	35759812	hsa-mir-146a	Mandibular Diseases	First, we established canine right mandibular DO and bone fracture models to evaluate the expression level of miR-146a in response to these procedures. In summary, miR-146a regulates mandibular DO by improving osteogenesis, and can serve as a potential target to shorten the therapy period of DO.
lncRNA target	35759812	hsa-mir-146a	Disorders of Excessive Somnolence	In summary, miR-146a regulates mandibular DO by improving osteogenesis, and can serve as a potential target to shorten the therapy period of DO.
other	35759812	hsa-mir-146a	Fractures, Bone	First, we established canine right mandibular DO and bone fracture models to evaluate the expression level of miR-146a in response to these procedures.
lncRNA target	35759451	hsa-mir-19a	Nasopharyngeal Carcinoma	The rescue experiments showed that BAMBI downregulation reversed the role of miR-19a-3p inhibition in NPC cells.
genetics_knock down_promote	35759163	hsa-mir-1184	Nasopharyngeal Carcinoma	Circ_0000523 overexpression promoted NPC cell proliferation and accelerated cell cycle progression, whereas miR-1184 overexpression reversed these effects; circ_0000523 knockdown suppressed NPC cell proliferation and induced cell cycle arrest, while miR-1184 inhibition counteracted these effects.
genetics_knock down_promote	35759156	hsa-mir-432	Colorectal Neoplasms	MYH9 overexpression counteracted the inhibiting effects of miR
other	35758549	hsa-mir-126a	Multiple Sclerosis	Specifically, miR-126a-5p in microglia is positively correlated with BBB integrity in four types of MS plaques.
circRNA target	35758280	hsa-mir-889	Osteosarcoma	Besides, circ_0078767 positively regulated KLF9 expression in OS cells via repressing miR-889. In conclusion, circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression.
genetics_knock down_promote	35758158	hsa-mir-380	Pancreatic Carcinoma	Next, the gain and loss-of-function experiments verified that knockdown of miR
lncRNA target	35758024	hsa-mir-31	Osteosarcoma	3p acts as an critical tumor suppressor through inhibiting MGAT1, results in suppressed Wnt/beta-Catenin pathway and decreased proliferation of OS cells; leads to increased apoptosis via Bcl-2/Bax pathway and inhibited migration and invasion ability via the EMT.
genetics_overexpression_promote	35757999	hsa-mir-124a	Uveal melanoma	Additionally, overexpression of miR-124a in UM cells diminished NSUN2 expression levels indicating that it is an upstream regulator of this response.
other	35757507	hsa-mir-7	Osteoarthritis	MiR-7 has been recognized as an osteoarthritis (OA-)-promoting factor, but the specific downstream pathway of miR-7 still remains unknown. Further investigation of the molecular regulatory mechanism of miR-7 might help develop a novel therapeutic method for OA.
lncRNA target	35756932	hsa-mir-23b	Cardiomyopathies	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
lncRNA target	35756932	hsa-mir-3175	Sepsis	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
lncRNA target	35756932	hsa-mir-23b	Sepsis	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
lncRNA target	35756932	hsa-mir-3175	Cardiomyopathies	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
lncRNA target	35756932	hsa-mir-23a	Cardiomyopathies	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
lncRNA target	35756932	hsa-mir-23a	Sepsis	hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells.
transcription factor target	35756810	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: These findings indicate that miR-21 and miR-125b, associated with the 10 hub genes, jointly participate in OSCC tumorigenesis, offering insight into the molecular mechanisms underlying OSCC as potential targets for early diagnosis, treatment and prognosis.
transcription factor target	35756810	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: These findings indicate that miR-21 and miR-125b, associated with the 10 hub genes, jointly participate in OSCC tumorigenesis, offering insight into the molecular mechanisms underlying OSCC as potential targets for early diagnosis, treatment and prognosis.
lncRNA target	35756803	hsa-mir-21	Fibrosis	MicroRNA-21 (miR-21) is a well-known fibrosis non-coding RNA, and its role in the development of OSF remains largely unclear. CONCLUSION: Our results suggest that the miR-21/PDCD4 axis mediates the myofibroblast activation of BMFs, and targeting this axis may exert an anti-fibrosis effect.
other	35756803	hsa-mir-21	Opitz GBBB Syndrome, X-Linked	MicroRNA-21 (miR-21) is a well-known fibrosis non-coding RNA, and its role in the development of OSF remains largely unclear. We showed the expression of PDCD4 was downregulated in OSF specimens and negatively correlated with miR-21.
other	35756791	hsa-mir-375	Squamous Cell Carcinoma of Head and Neck	The detection of miR-372 and miR-375 expression using cytobrush samples may assist in differentiating between OPMD and OSCC.
other	35756787	hsa-mir-760	Oral Submucous Fibrosis	RESULTS: NEAT1 and Tropomyosin-1 (TPM1) were significantly increased in OSF specimens, but miR-760 was decreased.
other	35756782	hsa-mir-375	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our results indicate the potential application of salivary miR-375 as a biomarker for the detection and long-term follow-up of OPMD.
other	35756773	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	This study addressed whether frequent miR-31 and MIR31HG co-upregulation occurred in oral squamous cell carcinoma (OSCC) and its clinical implications.
circulation_biomarker_diagnosis_up	35756772	hsa-mir-223	Diabetes, Gestational	targeted messenger RNA (mRNA) expression levels in GCB compared to peripheral blood (PB).
circulation_biomarker_diagnosis_up	35756772	hsa-mir-223	Periodontitis	targeted messenger RNA (mRNA) expression levels in GCB compared to peripheral blood (PB).
lncRNA target	35756764	hsa-mir-509	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our results suggest that the miR-509/plk1 axis may mediate the cancer stemness in oral cancer, and targeting this axis may attenuate the progression of oral cancer.
genetics_knock down_promote	35756756	hsa-mir-1266	Mouth Neoplasms	The phenotypic assays including proliferation activity, migration capacity, invasion, wound healing, and colony-forming abilities were conducted in oral cancer cells after knockdown of miR
lncRNA target	35756697	hsa-mir-877	Lung Neoplasms	5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC.
lncRNA target	35756672	hsa-mir-183	Nasopharyngeal Carcinoma	We concluded that OIP5-AS1 performed its biological functions via targeting miR
other	35756646	hsa-mir-411	Thyroid Neoplasms	5p were significantly decreased in tumor tissues compared with normal tissues in THCA.
other	35756646	hsa-mir-299	Thyroid Neoplasms	5p were significantly decreased in tumor tissues compared with normal tissues in THCA.
other	35756646	hsa-mir-410	Thyroid Neoplasms	5p were significantly decreased in tumor tissues compared with normal tissues in THCA.
genetics_overexpression_promote	35756606	hsa-mir-4800	Carcinoma, Hepatocellular	3p was overexpressed in HCC cells.
lncRNA target	35756415	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	The LINC01116-miRMMP1 axis provides a novel insight into the OSCC pathogenesis and offers potential therapeutic targets against OSCC.
lncRNA target	35756165	hsa-mir-204	Melanoma	5p in melanoma metastasis target organs could be used to develop novel approaches for the treatment of disseminated forms of the disease.
genetics_GWAS	35756164	hsa-mir-146a	Lupus Erythematosus, Systemic	mir-146a genetic polymorphisms in systemic lupus erythematosus patients: This study aimed to investigate the genetic polymorphisms of miR-146a SNPs (rs2910164, rs57095329, and rs2431697) in systemic lupus erythematosus (SLE) patients and their association with clinical manifestations.
target gene	35756081	hsa-mir-450b	Colorectal Neoplasms	Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis.
genetics_GWAS	35756079	hsa-mir-373	Osteoarthritis	Taken together, our study showed that CREB alleviates OA injury through regulating the expression of miR-373, which directly targeted METTL3, and finally relieved TFEB from METTL3-mediated epigenetic suppression. The CREB/miR-373/METTL3/TFEB axis may be used as a potential target for the treatment of OA.
circulation_biomarker_diagnosis_ns	35755441	hsa-mir-200a	Adenocarcinoma in Situ	miR-200a-3p expression in the serum MV and platelets had increased to 1.41 (p < 0.05) and 3.29 times (p < 0.001), respectively, in AIS patients compared with healthy controls, and was modified by severity of AIS. Our results presented new evidence that activated platelets could remotely modulate ET-1 and VEGFA expression in HUVEC via releasing miR-200a-3p-enriched PMVs, which provides a potential miRNA-based predictive biomarker and therapeutic strategy for atherosclerosis and AIS.
other	35754188	hsa-mir-203	Burns	Both MVs and PRP significantly downregulated gene expression of miRNA-203 & alphaSMA and immunoblotting analysis of MMP-3 and TGF-beta compared with the burn group.
genetics_knock down_suppress	35754140	hsa-mir-145	Keloid	CONCLUSION: Hsa_circ_0043688 knockdown inhibited cell growth and metastasis of keloid fibroblasts via miR
other	35754121	hsa-mir-21	Dermatitis, Atopic	5p (R = .20, p = .022).
other	35754121	hsa-mir-375	Dermatitis, Atopic	5p (R = .20, p = .022).
transcription factor target	35753437	hsa-mir-142	Breast Neoplasms	3p inhibited migration, invasion and metastatic potential of breast cancer cells.
other	35753367	hsa-mir-124	Stress Disorders, Post-Traumatic	BACKGROUND: MicroRNA3p (miR-124) plays an important role in neuroprotective functions in various neurological disorders, but whether miR-124 participates in the pathological progression of posttraumatic stress disorder (PTSD) remains poorly understood.
lncRNA target	35753017	hsa-mir-145	Muscular Diseases	Taken together, we concluded that miR5p promoted cell death to facilitate muscle dysfunctions via inactivating the PI3K/Akt/mTOR pathway.
genetics_overexpression_promote	35752700	hsa-mir-7	Arthritis, Rheumatoid	Finally, we overexpressed miR-7 in RA-FLS and discovered that miR-7 inhibited RA-FLS hyperproliferation, migration, invasion, and apoptosis, whereas ciRS-7 overexpression reversed these effects.
circulation_biomarker_diagnosis_up	35752392	hsa-mir-29c	Cognition Disorders	CONCLUSION: The plasma NCAM/amphiphysin 1 dual-labeled exosomal miR-29c-3p had potential advantages in the diagnosis of SCD.
exosome	35751950	hsa-mir-3681	ST Elevation Myocardial Infarction	Exosomal miR
exosome	35751950	hsa-mir-152	ST Elevation Myocardial Infarction	Exosomal miR
other	35751896	hsa-mir-489	Carcinoma, Non-Small-Cell Lung	3p in lung carcinoma may be the key to the earlier diagnosis and treatment of lung carcinoma.
transcription factor target	35751784	hsa-mir-326	Uterine Cervical Neoplasms	Upregulation of miR-326 decreased SMO expression and its downstream proteins but does not affect the proliferation of CSCC cells. The upregulation of miR-326 increased radiation sensitivity of the CSCC cell through downregulating SMO and its downstream proteins in the Hedgehog (Hh) signaling pathway.
other	35751569	hsa-mir-146a	Pre-Eclampsia	CONCLUSION: The expression of miR-146a decreased in severe PE and was negatively correlated with SMAD4 expression.
other	35751015	hsa-mir-145	Coronary Artery Disease	The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD.
other	35751015	hsa-mir-126	Coronary Artery Disease	MiR-126 and miR-155 showed significance with BMI grade, while only miR-133a showed significance with the obese patients in general.
other	35751015	hsa-mir-133a	Coronary Artery Disease	The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD.
other	35751015	hsa-mir-205	Coronary Artery Disease	The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD.
other	35751015	hsa-mir-182	Coronary Artery Disease	The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD.
other	35751015	hsa-mir-155	Coronary Artery Disease	MiR-126 and miR-155 showed significance with BMI grade, while only miR-133a showed significance with the obese patients in general.
other	35750202	hsa-mir-145	Spinal Cord Injuries	Further studies are needed to investigate the potential interplay between Nrf2 and miRNA145-5p in neuroinflammatory condition.
other	35750139	hsa-mir-582	Biliary Tract Neoplasms	3p) were identified and validated as diagnostic of BTC on univariable analysis.
other	35750139	hsa-mir-145	Biliary Tract Neoplasms	3p) were identified and validated as diagnostic of BTC on univariable analysis.
other	35750139	hsa-mir-92b	Biliary Tract Neoplasms	3p) were identified and validated as diagnostic of BTC on univariable analysis.
other	35750139	hsa-let-7a	Biliary Tract Neoplasms	3p) were identified and validated as diagnostic of BTC on univariable analysis.
other	35750046	hsa-mir-139	Amyotrophic Lateral Sclerosis	We identify the downregulation of miR-139, an MN-enriched microRNA, in FUS and sporadic ALS MN. We discover that miR-139 downregulation leads to the activation of canonical WNT signaling and demonstrate that the WNT transcriptional mediator beta-catenin is a major driver of MN degeneration in ALS.
genetics_overexpression_promote	35749939	hsa-mir-651	Ovarian Neoplasms	3p was overexpressed and downregulated to study the functional changes in ovarian cancer cells.
other	35749917	hsa-mir-200a	uterine corpus endometrial carcinoma	OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs.
other	35749917	hsa-mir-183	uterine corpus endometrial carcinoma	OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs.
other	35749917	hsa-mir-182	uterine corpus endometrial carcinoma	OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs.
other	35749917	hsa-mir-205	uterine corpus endometrial carcinoma	OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs.
other	35749917	hsa-mir-200b	uterine corpus endometrial carcinoma	OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs.
circulation_biomarker_diagnosis_ns	35749663	hsa-mir-145	Bipolar Disorder	CONCLUSION: Differential expression of five miRNAs in peripheral blood may be associated with the pathogenesis of BD-I, and hsa-miR
genetics_knock down_suppress	35748916	hsa-mir-630	Carcinoma, Non-Small-Cell Lung	CONCLUSION: CircDLG1 knockdown could impede NSCLC advancement through modulating the miR-630/CENPF axis, manifesting as a promising molecular target for NSCLC treatment.
lncRNA target	35748914	hsa-mir-4268	Stomach Neoplasms	Collectively, our present results indicate that the miR-4268/KRT80 axis acts as a potential therapeutic target for patients with GC.Abbreviations: Gastric cancer (GC); MicroRNAs (miRNAs); Keratin 80 (KRT80); differentially expressed genes (DEGs); chemoradiotherapy (CRT); negative nonsense sequence (NC); radioimmunoprecipitation assay (RIPA); polyvinylidene fluoride (PVDF).
lncRNA target	35748489	hsa-mir-485	Carcinoma, Hepatocellular	5p or upregulation of LSM4 reversed the inhibition of HCC cell malignant behavior by LINC01419 interference.
other	35748299	hsa-mir-637	Stomach Neoplasms	Circ_0017274 downregulation boosted CDDP sensitivity by acting on miR-637/CDX2 in CDDP-resistant GC cells.
other	35748251	hsa-mir-4463	Arteriosclerosis Obliterans	BACKGROUND: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous.
other	35748251	hsa-mir-4463	Osteoarthritis	BACKGROUND: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous.
transcription factor target	35748251	hsa-mir-4463	Ischemia	Inhibition of miR-4463 might be a potential strategy to protect endothelial cells and maintain vascular function in patients with lower limb ischemia and its complications.
genetics_knock down_promote	35747966	hsa-mir-433	Carcinoma, Non-Small-Cell Lung	3p knockdown or GRB2 overexpression counteracted the repressive effect of LINC01234 silencing on NSCLC cell malignant proliferation.
circRNA target	35747942	hsa-mir-19a	Carcinoma, Hepatocellular	In addition, circ_0001649 suppressed the development of sevoflurane-induced HCC cells through miR-19a-3p/SGTB axis. CONCLUSION: Our study demonstrated that sevoflurane inhibited HCC cell development via circ_0001649/miR-19a-3p/SGTB axis.
circulation_biomarker_diagnosis_up	35747760	hsa-mir-124	Polycystic Ovary Syndrome	3p expression in the serum of obese and nonobese PCOS patients.
lncRNA target	35747689	hsa-mir-152	Stomach Neoplasms	CONCLUSION: AG can decrease GC multiplication, clone formation and migration and induce apoptosis via modulating circKIF4A/miR
lncRNA target	35747602	hsa-mir-4298	Keratoconus	Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC.
lncRNA target	35747602	hsa-mir-4494	Keratoconus	Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC.
lncRNA target	35747602	hsa-mir-4263	Keratoconus	Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC.
lncRNA target	35747602	hsa-mir-4257	Keratoconus	Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC.
other	35747400	hsa-mir-542	Osteosarcoma	circ-RANGAP1/MicroRNA-542-3p/Myosin Regulatory Light Chain Interacting Protein Axis Modulates the Osteosarcoma Cell Progression.
virus_miRNA	35746694	hbv-mir-6	Hepatitis B, Chronic	HBV-miR-6 may play a role in the process of viral excretion or particle formation in vivo.
genetics_overexpression_promote	35745075	hsa-mir-21	ovarian clear cell carcinoma	Functional analyses indicated that miR-21 overexpressed in CCCO cells targeted tumor suppressor genes PTEN, TPM1, PDCD4, and MASP1.
other	35743776	hsa-mir-29b	Breast Neoplasms	These findings may contribute to better classify breast tumors having the triple negative phenotype, and suggest that the activation of the Vav1/miR-29b axis, precisely regulating the amount of an Akt isozyme crucial for tumor dissemination, could have great potential for driving more accurate therapies to TNBCs, often not eligible or resistant to treatments.
lncRNA target	35743464	hsa-mir-376a	Tuberous Sclerosis 1	Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway.
lncRNA target	35743464	hsa-mir-150	Tuberous Sclerosis 1	Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway.
lncRNA target	35743464	hsa-mir-136	Tuberous Sclerosis 1	Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway.
other	35743416	hsa-mir-155	Gastritis	Dynamic evaluation of miR-155 might enlighten its prognostic role in pediatric gastritis.
other	35743416	hsa-mir-155	Gastritis, Pediatric	Dynamic evaluation of miR-155 might enlighten its prognostic role in pediatric gastritis.
other	35743308	hsa-mir-92a	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-4492	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-let-7i	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-146a	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-4497	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-4497	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-92a	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-342	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-4492	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-146a	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-181b	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-26a	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-26a	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-181b	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-148a	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-148a	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-let-7i	Dermatitis, Atopic	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
other	35743308	hsa-mir-342	Alzheimer Disease	The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492).
lncRNA target	35743223	hsa-mir-149	Lung Neoplasms	5p, cyclin D1, and forkhead box protein M1 (FOXM1) expression analysis via qPCR.
epigenetics	35743167	hsa-mir-155	Leukemia	In this work, we show that combinatorial treatment of acute myeloid leukemia (AML) cells with DNA methylation inhibitors (5-Azacytidine), MYB inhibitors (Celastrol), and anti-miR-155 (AM155) ideally leads to overproduction of PU.1.
genetics_knock down_promote	35742991	hsa-mir-133a	dilated cardiomyopathy 1FF	Furthermore, the T3-mediated transcriptional activation of mitoK-ATP in the myocardium and NRCM was associated with the repression of the TH-inactivating enzyme, deiodinase 3 (Dio3), and an up-regulation of the T3-responsive miR-133a-3p. Mechanistically, the loss and gain of function experiments and reporter gene assays performed in NRCM, have revealed a new regulatory axis whereby the silencing of Dio3 under the control of miR-133a-3p drives the T3-dependent modulation of cardiac mitoK and mitoSur transcription.
lncRNA target	35742854	hsa-mir-654	Lung Neoplasms	5p inhibited the lung cancer cell epithelial-mesenchymal transition (EMT) process, cell proliferation, and migration using target-based, abundance-based, and ssGSEA-based bioinformatic methods and in vitro validation.
other	35742854	hsa-mir-654	Syphilis	We found that miR5p abundance was significantly elevated in LUAD tissues and correlated with patients' survival.
other	35741700	hsa-mir-29a	systemic primary carnitine deficiency disease	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-363	Fetal Growth Retardation	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-6126	systemic primary carnitine deficiency disease	In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated.
other	35741700	hsa-mir-29a	Alopecia	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-29c	systemic primary carnitine deficiency disease	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-363	Alopecia	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-874	Fetal Growth Retardation	In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated.
other	35741700	hsa-mir-29a	Fetal Growth Retardation	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-6126	Fetal Growth Retardation	In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated.
other	35741700	hsa-mir-29c	Alopecia	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-874	systemic primary carnitine deficiency disease	In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated.
other	35741700	hsa-mir-23a	Alopecia	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-23a	systemic primary carnitine deficiency disease	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-363	systemic primary carnitine deficiency disease	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-23a	Fetal Growth Retardation	5p and miR-23a-5p were downregulated.
other	35741700	hsa-mir-29c	Fetal Growth Retardation	5p and miR-23a-5p were downregulated.
other	35741665	hsa-mir-30	Glaucoma	RESULTS: circXPO5 significantly decreased in the glaucoma model and a ceRNA network analysis revealed that circXPO5 can bind to miR5p, which also binds to GRIN2A (ionotropic receptor NMDA type subunit 2A).
other	35741223	hsa-let-7	Colorectal Neoplasms	Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential.
other	35741223	hsa-mir-16	Colorectal Neoplasms	Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential.
other	35741223	hsa-mir-23	Colorectal Neoplasms	Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential.
other	35741194	hsa-mir-4324	Thyroid Cancer, Papillary	This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies.
other	35741194	hsa-mir-221	Thyroid Cancer, Papillary	This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies.
other	35741194	hsa-mir-125a	Thyroid Cancer, Papillary	This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies.
other	35741194	hsa-mir-146b	Thyroid Cancer, Papillary	This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies.
epigenetics	35741046	hsa-mir-10b	Sarcoidosis	Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR
epigenetics	35741046	hsa-mir-101-1	Sarcoidosis	Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR
epigenetics	35741046	hsa-mir-200a	Sarcoidosis	Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR3p), which have also been established to play roles in neoplastic transformation.
epigenetics	35741046	hsa-mir-338	Sarcoidosis	Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR3p), which have also been established to play roles in neoplastic transformation.
epigenetics	35741046	hsa-mir-101	Sarcoidosis	Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR
other	35740455	hsa-mir-141	Colorectal Neoplasms	The fluorescein isothiocyanate (FITC) probe and biotinylated probe are designed for a two-pronged approach to the detection of the urinary miR-21 and miR-141, both of which have demonstrated significance in the development and progression of colorectal cancer, a leading cause of mortality and morbidity.
other	35740455	hsa-mir-21	Colorectal Neoplasms	The fluorescein isothiocyanate (FITC) probe and biotinylated probe are designed for a two-pronged approach to the detection of the urinary miR-21 and miR-141, both of which have demonstrated significance in the development and progression of colorectal cancer, a leading cause of mortality and morbidity.
other	35740420	hsa-mir-17	CREST Syndrome	5p.
other	35740420	hsa-mir-17	Chronic Rhinosinusitis With Nasal Polyps	5p.
other	35740420	hsa-mir-203a	CREST Syndrome	5p.
other	35740420	hsa-mir-145	Chronic Rhinosinusitis With Nasal Polyps	5p.
other	35740420	hsa-mir-145	CREST Syndrome	5p.
other	35740420	hsa-mir-203a	Chronic Rhinosinusitis With Nasal Polyps	5p.
other	35740375	hsa-mir-133a	Myocardial Infarction	Moreover, we assessed a known myocardial infarction-related miR-133a in acute myocardial infarct patients vs. healthy subjects.
circulation_biomarker_prognosis_ns	35740344	hsa-mir-20a	Lymphoma, Non-Hodgkin	Moreover, hsa-miR-20a-5p/SNHG16 and hsa-miR-181a-5p/SNHG6 pairs' plasma levels were associated with overall survival and progression-free survival of NHL patients, being independent prognostic factors in a multivariate Cox analysis.
circulation_biomarker_prognosis_ns	35740344	hsa-mir-181a	Lymphoma, Non-Hodgkin	Moreover, hsa-miR-20a-5p/SNHG16 and hsa-miR-181a-5p/SNHG6 pairs' plasma levels were associated with overall survival and progression-free survival of NHL patients, being independent prognostic factors in a multivariate Cox analysis.
other	35740327	hsa-mir-381	Ovarian Neoplasms	3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions.
other	35740327	hsa-mir-31	Ovarian Neoplasms	3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions.
other	35740327	hsa-mir-23a	Ovarian Neoplasms	3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions.
other	35740327	hsa-mir-23b	Ovarian Neoplasms	3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions.
transcription factor target	35740314	hsa-mir-222	Obesity	The WD group also presented lower expression of Insig1 (miR-26a's target) and Cxcr4 (miR-222's target) than the Rev group.
other	35740034	hsa-mir-181b	Diabetes Mellitus, Type 2	The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction.
other	35740034	hsa-mir-181b	Endothelial Dysfunction 	The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction.
other	35740034	hsa-mir-181b	Acute Lung Injury	The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction.
genetics_overexpression_promote	35738798	hsa-mir-21	Melanoma	3p overexpression in tumor synergized with anti-PD-1 antibody by promoting tumor cell ferroptosis.
other	35738418	hsa-mir-183	Subarachnoid Hemorrhage	5p/TCF7L2 signaling axis to attenuate neurological deficit and endothelial dysfunction after SAH.
other	35738418	hsa-mir-183	Endothelial Dysfunction 	5p/TCF7L2 signaling axis to attenuate neurological deficit and endothelial dysfunction after SAH.
circulation_biomarker_diagnosis_down	35737431	hsa-mir-361	Abortion, Habitual	Our results showed that the expression of BCL-2 and lncRNA SRA was significantly higher in the blood samples of RPL patients than in controls, while the expression of miR
circRNA target	35736860	hsa-mir-106b	limb ischemia	CONCLUSION: All these findings suggested that RSV acted as an inhibitory factor in ox-LDL-induced endothelial injury via downregulating circ_0091822 to upregulate miR-106b-5p-related TLR4.
circRNA target	35736860	hsa-mir-106b	Atherosclerosis	CONCLUSION: All these findings suggested that RSV acted as an inhibitory factor in ox-LDL-induced endothelial injury via downregulating circ_0091822 to upregulate miR-106b-5p-related TLR4.
other	35735607	hsa-mir-92a-2	Autism Spectrum Disorde	Our results suggest that miR-92a5p is a strong risk factor for ASD and potentially contributes to neuropsychiatric disorders.
other	35735454	hsa-mir-10a	Glioblastoma	Our 3-microRNA signature (hsa-miR-20a, hsa-miR-21, hsa-miR-10a) may further empower glioblastoma multiforme prognostic evaluation in clinical practice and enrich drug repurposing pipelines.
genetics_overexpression_promote	35735238	hsa-mir-24	Influenza, Human	5p overexpression attenuates IAV-associated necroptosis and enhances viral replication, whereas deletion of miR
other	35735229	hsa-mir-24	Pre-Eclampsia	3p to regulate HSD11B2; thereby, the growth of placental trophoblasts is promoted in PE.
other	35735115	hsa-mir-27a	Carcinoma, Renal Cell	Moreover, we determined that the AC093157.1/miR-27a-3p axis can potentially regulate ZNF268 function in ccRCC.
lncRNA target	35735114	hsa-mir-410	Inflammatory Bowel Diseases	In addition, microRNA3p was remarkedly suppressed in IECs from UC patients.
transcription factor target	35735031	hsa-mir-29b	Atherosclerosis	In conclusion, this study reveals that the Lss-sensitive miR-29b-3p/CX3CL1 axis is an important regulatory target that affects vascular endothelial inflammation and AS development.
transcription factor target	35734966	hsa-mir-221	Breast Neoplasms	3 in HER2-positive breast cancer contributes to cancer cell proliferation and migration by directly targeting the tumor suppressors LASS2 and MBD2.
other	35734958	hsa-mir-143	Metabolic Diseases	Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes.
other	35734958	hsa-mir-143	Fatty Liver	Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes.
other	35734958	hsa-mir-143	Diabetes Mellitus	Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes.
other	35734958	hsa-mir-143	Obesity	Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes.
circulation_biomarker_diagnosis_up	35734774	hsa-mir-451	Pulmonary Arterial Hypertension	CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum.
circulation_biomarker_diagnosis_up	35734774	hsa-mir-451	Heart Diseases, Congenital	CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum.
circulation_biomarker_diagnosis_up	35734774	hsa-mir-204	Pulmonary Arterial Hypertension	CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum.
circulation_biomarker_diagnosis_up	35734774	hsa-mir-204	Heart Diseases, Congenital	CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum.
circRNA target	35733856	hsa-mir-93	Diabetic Nephropathies	CONCLUSION: Circ_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD via the miR5p/NLRP3 inflammasome pathway, suggesting its potential for clinical diagnosis and treatment of DKD.
target gene	35733786	hsa-mir-625	Osteosarcoma	Circ_0051079 silencing inhibits the malignant phenotypes of osteosarcoma cells by the TRIM66/Wnt/β-catenin pathway in a miR-625-5p-dependent manner.
other	35733784	hsa-mir-20	Lipodystrophy	In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation.
other	35733784	hsa-mir-320d	Lipodystrophy	In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation.
other	35733784	hsa-mir-20a	Lipodystrophy	In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation.
lncRNA target	35733703	hsa-mir-206	Polycystic Ovary Syndrome	Our report was designed to explore whether liquiritin play a role in PCOS by regulating human ovarian granulosa cell-like KGN cells proliferation and apoptosis through miR-206/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway, and to further elucidate the underlying molecular mechanisms. In conclusion, our findings suggested that liquiritin exerted anti-proliferative and apoptosis-inducing roles in KGN cells via miR-206/PI3K/AKT pathway, suggesting that liquiritin may be an effective therapeutic target for PCOS treatment.
lncRNA target	35733354	hsa-mir-195	Osteoarthritis	CONCLUSIONS: Our study is a proof-of-concept demonstration for targeting m6A-modified circRERE and its target miR5p/IRF2BPL/beta-catenin as potential therapeutic strategies for OA treatment.
genetics_knock down_promote	35733309	hsa-mir-626	Carcinoma, Endometrioid	Besides, CDKN1B overexpression of miR-626 knockdown reversed the effects of knocking down circ_0000437 on EC cells.
transcription factor target	35733144	hsa-mir-218	Chediak-Higashi Syndrome	Interestingly, we identified that CH-SEVs were enriched in miRNA-218 and ITGBL1 protein, which played important roles in promoting fibroblast activity via activation of the downstream TGFbeta1-SMAD2/3 pathway in vitro.
other	35733067	hsa-mir-155	Inflammation	MicroRNA(miR)5p is reportedly increased significantly in OLP and is known to regulate inflammation.
genetics_knock down_promote	35733067	hsa-mir-155	Osteoporosis-pseudoglioma syndrome	5p in OLP AFs augmented IL-6 and IL-8 release and decreased SOCS1 expression, whereas knockdown of miR
other	35733067	hsa-mir-155	Osteochondromatosis	This study aimed to investigate the role of miR5p in fibroblasts of OLP lesions.
lncRNA target	35732999	hsa-mir-1291	Pancreatic Carcinoma	The efficacy of a BioRNA, miR-1291, in the inhibition of pancreatic cancer PDO and PDX growth is exemplified in this chapter.
other	35732605	hsa-mir-28	Cardiomyopathy, Hypertrophic, Familial	Methods Real-time quantitative PCR was used to detect the expressions of miR3p, FOXP3, and IL-17 mRNA in FHC colorectal epithelial cells and colorectal cancer cells (HCT116, Caco-2, and LoVo).
other	35732605	hsa-mir-28	Colorectal Neoplasms	3p in colorectal cancer cells decreased, while the levels of FOXP3 and IL-17 increased.
exosome	35732322	hsa-mir-34a	Colorectal Neoplasms	Re-analysis of published miRNA profiles of CRC tumours or CRC exosomes revealed that only 2 out of 29 miRNAs were up-regulated in all datasets including ours (miR-34a and miR3p).
exosome	35732322	hsa-mir-25	Colorectal Neoplasms	Re-analysis of published miRNA profiles of CRC tumours or CRC exosomes revealed that only 2 out of 29 miRNAs were up-regulated in all datasets including ours (miR-34a and miR3p).
lncRNA target	35732230	hsa-mir-155	Osteoarthritis	In conclusion, PCB153 could promote the degradation of the extracellular matrix of chondrocytes by upregulating miR-155 via a mechanism related to the activation of the PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling pathway, which suppressed autophagy and facilitated the development of OA. MiR-155 may represent potential therapeutic targets to alleviate the development of OA.
transcription factor target	35732226	hsa-mir-135	Hepatitis B	Immunohistochemical staining and HBV core particle DNA analysis confirmed that HBV replication in the liver was strongly inhibited by AAV8-amiRNA135.
transcription factor target	35732048	hsa-mir-15a	Obesity	Furthermore, our findings suggested that miR-15a and its target gene(s) might represent new targets for investigating intramuscular fat deposits in cattle and treating human obesity.
lncRNA target	35732008	hsa-mir-34a	External Auditory Canal Squamous Cell Carcinoma	SIGNIFICANCE: The expression level of miR-34a may predict a prognosis in patients with advanced-stage EACSCC.
other	35731831	hsa-mir-223	Abortion, Spontaneous	Moreover, miR-223 was downregulated in the villous tissues of patients with SA and was further predicted and shown to negatively interact with circ-CCNB1, which is involved in trophoblast proliferation and invasion. CONCLUSION: Circ-CCNB1 served as a modulator of trophoblast proliferation and invasion by sponging miR-223, thus forming a regulatory network of circ-CCNB1/miR-223/SIAH1 in modulating CCNB1 nuclear translocation, which enabled us to elucidate the molecular mechanisms involved in normal embryo implantation or in SA.
other	35731638	hsa-mir-103a	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-15a	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-208a	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-141	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-124	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-155	Carcinoma, Hepatocellular	No significant difference was observed in miRNA expression between advanced fibrosis and early hepatic fibrosis apart from a significant downregulation of miR5p in advanced fibrosis.
other	35731638	hsa-mir-499a	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731638	hsa-mir-205	Carcinoma, Hepatocellular	RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients.
other	35731336	hsa-mir-621	Esophageal Squamous Cell Carcinoma	In conclusion, circ_0000705 promoted proline metabolism and malignant progression of ESCC by regulating the miR621/PYCR1 axis.
lncRNA target	35731327	hsa-mir-223	Hepatitis B, Chronic	The microRNA MiR-223 is expressed in several diseases, including HBV-associated disease, while the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a major role in pyroptosis. Thus, miR-223 downregulation plays an important role in HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome, suggesting that miR-223 is a potential therapeutic target for alleviating HBV-GN inflammation.
genetics_overexpression_suppress	35731327	hsa-mir-223	Necrobiotic Disorders	Moreover, transfection with HBx and NLRP3 overexpression plasmids increased the expression of pyroptosis-related proteins, especially in the presence of miR-223 inhibitors.
lncRNA target	35731049	hsa-mir-675	Wilms Tumor	RESULTS: The gene expression levels of lncRNA H19 and miR-675 were markedly downregulated in nephroblastoma tissues (p<0.05), while that of TGFBI was notably upregulated (p<0.05). CONCLUSIONS: LncRNA H19 may inhibit TGFBI expression by regulating miR-675 level, so as to weaken the proliferation and enhance the apoptosis of nephroblastoma cells.
genetics_overexpression_promote	35731017	hsa-mir-2765	Lipidoses	Overexpression of miR
lncRNA target	35730908	hsa-mir-1297	Squamous Cell Carcinoma of Head and Neck	TFAP2A-AS1 exerts an oncogenic effect in OSCC via the TFAP2A-AS1/miR-1297/TFAP2A axis, which may provide new targets and strategies for OSCC treatments.
lncRNA target	35730670	hsa-mir-19a	Fractures, Bone	CONCLUSION: This study is the first to demonstrate that the miR-19a-3p/FOXF2 axis has a pivotal role in alcohol-impaired fracture healing, and may be a potential therapeutic target.
lncRNA target	35730574	hsa-mir-206	Osteosarcoma	Inhibition of miR-206 in EVs partially reversed the inhibitory effect of EVs on malignant behaviors of OS cells.
transcription factor target	35730531	hsa-mir-489	Reperfusion Injury, Cerebral Ischemia	Taken together, by targeting SIRT1, elevated miR
circulation_biomarker_diagnosis_up	35730503	hsa-mir-106a	Hearing Loss, Sensorineural	Firstly, upregulated miR-106a was observed in the peripheral blood sample of SNHL patients.
genetics_overexpression_promote	35730500	hsa-mir-4739	Esophageal Squamous Cell Carcinoma	We demonstrated that miR-4739 overexpression exerted an inhibitory effect on ESCC cells by preventing the expression of homeobox C10 via the vascular endothelial growth factor A/phosphatidylinositol 3-kinase/AKT pathway, indicating the potential of this microRNA as a treatment target in ESCC.
lncRNA target	35730485	hsa-mir-145	Triple Negative Breast Neoplasms	CONCLUSION: ST8SIA6-AS1 exerts an oncogenic role in TNBC by interacting with miR5p to up-regulate CDCA3 expression and inactivate the p53/p21 signaling, highlighting ST8SIA6-AS1 as a promising molecular target to combat TNBC.
other	35730470	hsa-mir-873	Colorectal Neoplasms	This study demonstrated a novel TDRG1/miR5p/PRKAR2 signaling in CRC progression.
genetics_knock down_promote	35730423	hsa-mir-125b	Colorectal Neoplasms	Knockdown of MIR4435-2HG/Sema4D or overexpression of miR-125b-5p inhibited CRC cell proliferation and aggressiveness; overexpression of MIR4435-2HG/Sema4D or knockdown of miR-125b-5p prompted the malignant behaviors of cancer cells.
transcription factor target	35730258	hsa-mir-144	Heart Failure	3p alleviated Dox-induced cardiac dysfunction and cell apoptosis via targeting SOCS2, providing a novel evidence of miR
lncRNA target	35730141	hsa-mir-520d	Aortic Aneurysm, Thoracic	CONCLUSIONS: HOXA-AS2 up-regulates KIAA1522 through targeting miR-520d-3p/IGF2BP3 to drive VSMC growth in TAA.
exosome	35729564	hsa-mir-762	Burns	Moreover, the enrichment of miR-762 was detected in iPSCs-KCs-Exos and was found to target promyelocytic leukemia (PML) as a means of regulating cell migration through a mechanism tie to integrin beta1 (ITGB1).
other	35729178	hsa-mir-125a	Acute Kidney Injury	Pre-operative miR-125a-5p was expressed at lower levels in urine from patients with AKI when adjusted for urinary creatinine. Pre-operative levels of podocalyxin EVs, urinary particle concentrations and miR-125a-5p had moderate AKI predictive value and, in a logistic model together with ICU lactate levels, offered good (AUC = 82%) AKI prediction.
genetics_overexpression_promote	35729160	hsa-mir-18b	Osteosarcoma	The results showed that miR-18b-5p was overexpressed in human OS tissues and cell lines.
transcription factor target	35729047	hsa-mir-221	Arthritis, Rheumatoid	The expression levels of RA-related miRs and target genes were subsequently detected, and the target of miR-221 was confirmed by the dual-luciferase reporter assay.
lncRNA target	35728587	hsa-mir-95	Stomach Neoplasms	LINC01088 inhibits gastric cancer cells' proliferation, invasion, and migration by regulating the miR-95/LATS2 pathway via the ceRNA mechanism.
genetics_knock down_promote	35728571	hsa-mir-1228	Uterine Cervical Neoplasms	This study aimed to investigate the functional effect of UTMD-mediated miR-1228 knockdown in cervical-cancer cells.
lncRNA target	35728350	hsa-mir-564	Aortic Dissection	In particular, animal experiments demonstrated that miR-564 can alleviate the progression of AD mainly through mediating phenotypic swithing and inflammation which was consistent with clinical evaluation.
other	35727952	hsa-mir-146a	Myocardial Infarction	Aging impairs this miR-146a-5p-regulated MMP2/16-MLCK3-p-MLC2 contractile axis, leading to compromised contractile function and increased susceptibility to heart failure.
lncRNA target	35727063	hsa-mir-451a	Nerve Degeneration	3zeta transcript upon being targeted by miR-451a promotes JNK phosphorylation hence culminating into neuronal death by activation of apoptotic machinery.
transcription factor target	35727063	hsa-mir-451a	West Nile Fever	Inhibition of miR-451a upon neuronal infection by JEV/WNV helped reduce apoptotic machinery activation hence providing us with possible future therapeutic strategy in ameliorating flavivirus-induced neurological manifestations and overall disease burden in terms of morbidity.
transcription factor target	35727063	hsa-mir-451a	Encephalitis, Japanese	Inhibition of miR-451a upon neuronal infection by JEV/WNV helped reduce apoptotic machinery activation hence providing us with possible future therapeutic strategy in ameliorating flavivirus-induced neurological manifestations and overall disease burden in terms of morbidity.
transcription factor target	35727063	hsa-mir-451a	Death	3zeta transcript upon being targeted by miR-451a promotes JNK phosphorylation hence culminating into neuronal death by activation of apoptotic machinery.
genetics_overexpression_promote	35726535	hsa-mir-181a	Hypertrophy	Cardiac hypertrophy was suppressed by overexpression of a miR-181a inhibitor and enhanced by overexpression of a miR-181a mimic.
circulation_biomarker_diagnosis_ns	35726148	hsa-mir-375	Esophageal Squamous Cell Carcinoma	Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls.
circulation_biomarker_diagnosis_ns	35726148	hsa-mir-1	Esophageal Squamous Cell Carcinoma	Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls.
circRNA target	35726081	hsa-mir-185	Parkinson Disease	Hsa_circ_0004381 could contribute to MPP(+)-triggered neuron injury by targeting the miR5p/RAC1 axis, which provided a novel insight into the pathogenesis and treatment of PD.
genetics_knock down_promote	35725976	hsa-mir-448	Colorectal Neoplasms	Knockdown of XIST upregulates miR-448 to impede malignant behaviors of CRC cells via inhibiting GRHL2.
other	35725663	hsa-mir-200a	Anorectal Malformations	Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis.
other	35725663	hsa-mir-200b	Anorectal Malformations	Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis.
other	35725663	hsa-mir-200	Anorectal Malformations	Notably, compared to the control, the relative expression of miR-200 family members was highly upregulated in ARM fetal rats. CONCLUSIONS: Our findings suggest the involvement of ncRNAs, especially the miR-200 family members, in the pathogenesis of lumbosacral spinal cord dysplasia in ARM fetal rats.
other	35725663	hsa-mir-429	Anorectal Malformations	Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis.
other	35725663	hsa-mir-200c	Anorectal Malformations	Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis.
other	35725615	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	Taken togeter, these data revealed the important role of circ-EPB41 in regulating NSCLC cell invasion and proliferation by modifying miR3p/eIF5A axis-mediated stemness.
transcription factor target	35725311	hsa-mir-200c	Chronic  Rhinosinusitis With Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
transcription factor target	35725311	hsa-mir-200c	Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
transcription factor target	35725311	hsa-mir-200b	Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
transcription factor target	35725311	hsa-mir-200b	Chronic  Rhinosinusitis With Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
transcription factor target	35725311	hsa-mir-429	Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
transcription factor target	35725311	hsa-mir-429	Chronic  Rhinosinusitis With Nasal Polyps	GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP.
genetics_GWAS	35724768	hsa-mir-26b	Pulmonary Arterial Hypertension	In addition, it was found that SNPs influenced the COX-2, miR-26b-5p, and miR-146a-5p levels in PAH.
genetics_GWAS	35724768	hsa-mir-146a	Pulmonary Arterial Hypertension	In addition, it was found that SNPs influenced the COX-2, miR-26b-5p, and miR-146a-5p levels in PAH.
transcription factor target	35724605	hsa-mir-203a	Colitis	CONCLUSION: HucMSC-Ex ameliorates colitis through the suppression of casp11/4-induced macrophage pyroptosis, and hucMSC-Ex carrying miR-203a-3p.2 inhibits casp4-induced macrophage pyroptosis in an inflammatory environment.
other	35724459	hsa-let-7c	Lip Neoplasms	Particularly, we identified three miRNA signatures in which miR-128a was significantly upregulated and miR-23a and let-7c were significantly downregulated in patients with lower lip cancer. Remarkably, let-7c identified to be a promising prognostic factor for lip cancer.
exosome	35724457	hsa-mir-497	Cardiomyopathies	Therefore, we determine that MSCs-derived exosomes prevent sepsis-induced myocardial injury by a circRTN4/miR5p/MG53 pathway.
exosome	35724457	hsa-mir-497	Sepsis	Therefore, we determine that MSCs-derived exosomes prevent sepsis-induced myocardial injury by a circRTN4/miR5p/MG53 pathway.
lncRNA target	35724456	hsa-mir-371a	Liver Neoplasms	The above results revealed that PTEN functioned as a key target to regulate the autophagy in the process where emodin inhibited the malignant outcome of LCCLs via miR-371a-5p, which further provided a theoretical basis for the application of traditional Chinese medicine (TCM) on clinical tumors.
circRNA target	35723810	hsa-mir-526b	Carcinoma, Hepatocellular	Functionally, circEIF3I regulation in HCC cell progression was associated with miR-526b-5p sponging function and HGF upregulation could attenuate tumor-inhibiting roles of miR-526b-5p. CONCLUSION: CircEIF3I was an oncogenic circRNA in HCC-, and interfering circEIF3I exhibited anti-HCC activity via circEIF3I-miR-526b-5p-HGF/c-Met pathway.
genetics_knock down_promote	35723715	hsa-mir-128	Pulpitis	CONCLUSION: This study revealed that knockdown of PVT1 may suppress the damage in pulpitis cell models induced by LPS via targeting miR
other	35723551	hsa-mir-1183	Osteoarthritis	RESULTS: CircCDK14 and KLF5 expression were significantly decreased, while miR-1183 was increased in OA cartilage tissues and IL-1beta-treated chondrocytes in comparison with controls. CONCLUSION: CircCDK14 reintroduction assuaged IL-1beta-caused chondrocyte damage by the miR-1183/KLF5 pathway, providing a diagnostic biomarker for OA.
genetics_overexpression_promote	35723400	hsa-mir-1290	Carcinoma, Ovarian Epithelial	In the EOC group, miRNA-1290 was significantly overexpressed in serum exosomes and tissues as compared to benign ovarian neoplasm group (fold change >/= 2, p < 0.05). Serum exosomal miR-1290 could be considered as a biomarker for differential diagnosis of EOC from benign ovarian neoplasm and SOCS4 might be potential target gene of miR-1290 in EOC.
other	35723379	hsa-mir-93	Squamous Cell Carcinoma of Head and Neck	5p and H19 in OSCC.
other	35723379	hsa-mir-205	Squamous Cell Carcinoma of Head and Neck	5p and H19 in OSCC.
other	35723379	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	5p and H19 in OSCC.
other	35723379	hsa-mir-200c	Squamous Cell Carcinoma of Head and Neck	5p and H19 in OSCC.
target gene	35723348	hsa-mir-22	Carcinoma, Hepatocellular	MicroRNA-22-3p and MicroRNA-149-5p Inhibit Human Hepatocellular Carcinoma Cell Growth and Metastasis Properties by Regulating Methylenetetrahydrofolate Reductase.
target gene	35723348	hsa-mir-149	Carcinoma, Hepatocellular	MicroRNA-22-3p and MicroRNA-149-5p Inhibit Human Hepatocellular Carcinoma Cell Growth and Metastasis Properties by Regulating Methylenetetrahydrofolate Reductase.
other	35723300	hsa-mir-1270	Osteoporosis-pseudoglioma syndrome	A previous study showed that miR-1270 was upregulated in monocytes derived from postmenopausal women with OP.
exosome	35723199	hsa-mir-222	Carcinoma, Small Cell	3p/PDLIM2/PFKL axis in LSCC tumorigenesis, and in concert with the importance of TAM exosomes and glycolysis, could be potentially translated to LSCC clinics.
genetics_knock down_promote	35723188	hsa-mir-635	Carcinoma, Non-Small-Cell Lung	Additionally, miR-635 re-expression suppressed NSCLC cell malignant phenotypes mentioned above and immune escape, which were attenuated by PDL1 overexpression. In all, circ_0092012 knockdown suppressed NSCLC cell oncogenic phenotypes and immune escape by miR-635/PDL1 axis.
lncRNA target	35723058	hsa-mir-145	Glomerulonephritis, Membranous	5p inhibitor and LY294002 encouraged proliferation and inflammation through PI3K/AKT pathway in HMCs.
genetics_overexpression_promote	35723009	hsa-mir-221	Carcinoma, Hepatocellular	3p was overexpressed.
genetics_knock down_suppress	35722996	hsa-mir-664b	Colorectal Neoplasms	CAFs-sEV circN4BP2L2 knockdown restrained CRC cell proliferation and migration by regulating miR-664b-3p/HMGB3 pathway.
lncRNA target	35722872	hsa-mir-22	Heart Defects, Congenital	CONCLUSIONS: Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration.
lncRNA target	35722872	hsa-mir-503	Heart Defects, Congenital	CONCLUSIONS: Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration.
circRNA target	35722711	hsa-mir-370	Acute Kidney Injury	Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR3p/NR4A3 axis.
lncRNA target	35722429	hsa-mir-505	Ovarian Neoplasms	Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR
transcription factor target	35722425	hsa-mir-145	Cerebral Hemorrhage	5p protects against brain injury following HICH by targeting MMP2, suggesting a possible therapeutic mechanism for HICH.
lncRNA target	35722406	hsa-mir-81	Dementia, Vascular	In this study, we investigated the effect of EA at the Baihui (GV 20) and Shenting (GV 24) acupoints on spatial learning and memory ability, and the expression level of microRNA-81 (miR-81), interleukin-16 (IL-16), and postsynaptic density protein-95 (PSD-95) in the frontal cortex of VaD rats. CONCLUSIONS: In VaD rats, EA may improve spatial learning and memory through miR-81/IL-16/PSD-95 pathway.
virus_miRNA	35722385	hbv-mir-3	Hepatitis B, Chronic	HBV-miR-3 was positively correlated with HBV DNA, pgRNA, and particularly HBsAg in TN CHB patients.
circRNA target	35722376	hsa-mir-548m	Hyperglycemia	CONCLUSIONS: In hyperglycemia, the TTR-induced increase in circ_0007411 could repress retinal neovascularization via the miR-548m/PTPN12/SKP1/EGFR pathway.
other	35722357	hsa-mir-203b	Stomach Neoplasms	Long non-coding RNA (FALEC) promotes malignant behaviors of gastric cancer cells by regulating miR-203b/PIM3 axis.
lncRNA target	35722355	hsa-mir-199	Osteoarthritis	Our findings may lead to the development of miR-199a-5p-based targeted therapy for OA.
lncRNA target	35722355	hsa-mir-199a	Osteoarthritis	Our findings may lead to the development of miR-199a-5p-based targeted therapy for OA.
other	35722091	hsa-mir-181b	Aortic Valve Disease	The LINC00702-miR-181b-5p-SPP1 axis might participate in the development of CAVD.
lncRNA target	35721888	hsa-mir-3121	Colorectal Neoplasms	CONCLUSION: TNFRSF10A-AS1 exerts a tumor-promoting function through the miR3p/HuR axis in CRC, indicating that it may be a novel target for CRC therapy.
other	35721535	hsa-mir-142	Diabetic Nephropathies	Conclusion: Ferroptosis existed in glomerular intrinsic cells of ADN group and its potential key candidate gene was ALOX15 which may be regulated by miR-142 and miRNA-650, TFs (CREBBP, EP300, HDAC1, MTA1, SPI1, STAT6) and E3 ligases related to ubiquitination (PML, ZMIZ1, MARCHF1, MARCHF3, MARCHF8, MARCHF11).
other	35721225	hsa-mir-98	COVID-19	negative controls.
other	35721225	hsa-mir-423	COVID-19	negative controls.
other	35721225	hsa-mir-1246	COVID-19	negative controls.
other	35721225	hsa-mir-32	COVID-19	negative controls.
lncRNA target	35721175	hsa-mir-19b	Liver Cirrhosis	BMSC and FA treatment attenuated HSC activation and liver fibrosis by inhibiting cytoskeletal rearrangement and delivering miR-19b-3p to activated HSCs, inactivating RhoA/ROCK signalling.
lncRNA target	35720932	hsa-mir-130a	Diabetes Mellitus, Type 2	XIST has the capacity to promote iron overload and iron overload-related T2D initiation and development through inhibition of ALK2 expression by sponging miR-130a-3p, and that targeting this axis may be an effective strategy for treating patients with T2D.
genetics_knock down_suppress	35720634	hsa-mir-488	Cicatrix	In conclusion, the knockdown of lncRNA-NEAT1 expression can inhibit hypoxia-induced scar fibroblasts proliferation through regulation of the miR3p/COL3A1 axis, which will provide a novel therapeutic target for the treatment of hypertrophic scars.
genetics_knock down_promote	35720620	hsa-mir-382	Adenocarcinoma of Lung	3p inhibition promoted proliferation and inhibited apoptosis in LA cell lines, which was restored by SAE1 knockdown.
genetics_overexpression_suppress	35720506	hsa-mir-99a	Uterine Cervical Neoplasms	The overexpression of miR-99a-5p induced apoptosis and inhibited glycolysis in CC cells by targeting RRAGD.
other	35720471	hsa-mir-148a	Colonic Neoplasms	HLA-G is one of the prognostic factors in colon cancer, and decreased miR-148a expression in colon cancer tissues may be associated with HLA-G-mediated carcinogenesis.
other	35720471	hsa-mir-148	Colonic Neoplasms	HLA-G is one of the prognostic factors in colon cancer, and decreased miR-148a expression in colon cancer tissues may be associated with HLA-G-mediated carcinogenesis.
other	35720314	hsa-mir-363	pancreatic adenocarcinoma	Subsequently, hsa-miR3p was recognized as a critical microRNA regulating SQLE expression and thereby influencing PAAD patient outcome.
genetics_overexpression_promote	35720183	hsa-mir-29a	Reperfusion Injury, Steatotic Liver Ischemia	Overexpression of miR-29a-3p downregulated the expression of Ireb2 and inhibited ferroptosis. HO-1/BMMSCs could suppress ferroptosis by targeting Ireb2 via the exosomal transfer of miR-29a-3p.
other	35720085	hsa-mir-940	Intracranial Hemorrhages	From the constructed miRNA-TF-mRNA regulatory network, we identified three axes, hsa-miR-940/RUNX1/TIMP1, hsa-miR-571/SP3/TIMP1, and hsa-miR-571/SP3/PLAUR, which may be involved in the development of ICH.
other	35719399	hsa-mir-125a	Zika Virus Infection	3p were related to signaling pathways modulated during infection and immune response.
other	35719399	hsa-mir-146	Zika Virus Infection	3p were related to signaling pathways modulated during infection and immune response.
other	35719399	hsa-mir-142	Zika Virus Infection	3p were related to signaling pathways modulated during infection and immune response.
other	35719385	hsa-mir-140	Respiratory Distress Syndrome	In conclusion, we demonstrated a new potential regulatory mechanism underlying ARDS (the TUG1/miR5p/NFE2L2 ceRNA regulatory pathway), which may help in further exploring the pathogenesis of ARDS.
other	35719192	hsa-mir-149	uterine corpus endometrial carcinoma	miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma.
other	35719137	hsa-mir-206	Neuralgia	CONCLUSIONS: EA can relieve neuropathic pain by regulating the miR3p/BDNF pathway, thus exerting anti-inflammatory and antiapoptotic effect.
lncRNA target	35718954	hsa-mir-214	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718954	hsa-mir-543	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718954	hsa-mir-125	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718954	hsa-mir-378	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718954	hsa-mir-142	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718954	hsa-let-7	Periodontitis	Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis.
lncRNA target	35718922	hsa-mir-193b	Pancreatic Carcinoma	CONCLUSIONS: Our findings suggest that miR-193b expression suppresses PDAC cell proliferation, migration, invasion, and EMT through inhibition of eEF2K/MAPK-ERK oncogenic axis and that miR-193b-based RNA therapy might be an effective therapeutic strategy to control the growth of PDAC.
other	35718188	hsa-mir-125b	Diabetic Retinopathy	To summarize, our study revealed that crocetin has a protective effect on Hg-induced DR by regulating the lncRNA NEAT1/miR-125b-5p/SOX7 molecular axis.
genetics_overexpression_promote	35718122	hsa-mir-150	Nasopharyngeal Neoplasms	The function of overexpression of miR
genetics_overexpression_promote	35717938	hsa-mir-107	Cardiomyopathies	miR-107 overexpression remarkably improved cardiac function and histological changes, decreased inflammatory factors, and alleviated the sepsis-induced myocardial injury in rats.
genetics_overexpression_promote	35717938	hsa-mir-107	Sepsis	miR-107 overexpression remarkably improved cardiac function and histological changes, decreased inflammatory factors, and alleviated the sepsis-induced myocardial injury in rats.
genetics_knock down_promote	35717759	hsa-mir-488	Endometriosis	Circ_0004712 knockdown suppressed the proliferation and metastasis of ectopic endometrial epithelial cells via miR3p/ROCK1 axis in vitro, suggesting a new insight into the pathogenesis of endometriosis.
circulation_biomarker_diagnosis_ns	35717586	hsa-mir-122	Alcohol Withdrawal Syndrome	Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity.
target gene	35717572	hsa-mir-346	Carcinoma, Non-Small-Cell Lung	Hsa_circ_0006427 Suppresses Multiplication, Migration and Invasion of Non-Small Cell Lung Cancer Cells through miR-346/VGLL4 Pathway.
genetics_knock down_promote	35717565	hsa-mir-138	Squamous Cell Carcinoma of Head and Neck	5p, and EZH2 knockdown could counteract the promotional impact of miR
transcription factor target	35717485	hsa-mir-34c	Hypertension, Pulmonary	Provides preliminary data to conduct studies targeting miR34c expression in vivo in animal models of pulmonary hypertension to identify the mechanistic role of miR34c in angiogenesis in the lung vasculature.
transcription factor target	35717476	hsa-mir-143	Lung Neoplasms	CONCLUSION: The findings showed that miR-143 could reduce cell proliferation, invasion, and migration by reducing CXCR4, Vimentin, MMP-1, Snail-1, C-myc expression level, and increasing E-cadherin expression levels in lung cancer cells and might be a potential target in NSCLC's targeted therapy.
genetics_GWAS	35717150	hsa-mir-208b	Cardiomyopathy, Hypertrophic, Familial	These findings suggest that FHCM patients with MYBPC3 gene mutations have a specific miRNA expression profile, and that miR-208b-3p is significantly upregulated in cardiac hypertrophy. Our results also indicate that miRNA-208b-3p activates the Wnt signaling pathway through its target gene to promote cardiac hypertrophy.
transcription factor target	35717088	hsa-mir-466h	Alzheimer Disease	Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Ralpha/TGF-betaR2/Abeta-42/AChE pairs) were demonstrated that they were more related to PM(2.5)-induced brain injury.
transcription factor target	35717088	hsa-mir-125b	Alzheimer Disease	Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Ralpha/TGF-betaR2/Abeta-42/AChE pairs) were demonstrated that they were more related to PM(2.5)-induced brain injury.
other	35716750	hsa-mir-20a	Neurodevelopmental Disorders	The placenta sEVs derived miRNAs, especially miR-320a-3p, might contribute to an increased risk of neurodevelopmental delays.
other	35716541	hsa-mir-200a	Neurotic Disorders	RESULTS: XYS reduced the anxiety and depression-like behaviors associated with chronic stress and reduced the expression of miR-200a/b-3p and neuronal apoptosis in the prefrontal cortex (PFC).
other	35716513	hsa-mir-367	Schizophrenia	SMAD7-EGR1 may be promising biomarkers for SCZ.
circulation_biomarker_diagnosis_down	35716001	hsa-mir-195	Pneumonia, Mycoplasma	5p was decreased in PE serum samples and cell lines, serving as a potential biomarker in protecting PE exacerbation by targeting FGF2.
lncRNA target	35715921	hsa-mir-233	Uterine Cervical Neoplasms	This study suggests that XIAP MMSNs with miR-233 material suppress cervical cancer cell progression and tumor growth when augmenting radiosensitization of cancer cells, providing evidence for targeted therapy for the disease.
circulation_biomarker_diagnosis_up	35715903	hsa-mir-153	Lung Neoplasms	The study's purpose was to predict micro-nodular lung cancer (mnLC), such as adenocarcinoma in situ (AIS), micro-invasive adenocarcinoma (MIA), and invasive adenocarcinoma stage 1 (IA(1)) based on serum extracellular nano-vesicles (sEVs) miR
transcription factor target	35715868	hsa-mir-181a	Cardiotoxicity	Finally, upregulation or downregulation of miR-181a-5p levels in MSC-EVs enhanced or weakened therapeutic effects on Dox-induced cardiotoxicity through modulating ER stress-induced apoptosis.
other	35715818	hsa-mir-888	Langer-Giedion Syndrome	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-1248	Langer-Giedion Syndrome	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-888	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-376a	Langer-Giedion Syndrome	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-376a	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-1248	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression.
other	35715818	hsa-mir-1248	high grade glioma	We also highlighted a critical oncogenic role for miR-1248 in gliomas tumours.
transcription factor target	35715772	hsa-mir-498	Breast Neoplasms	The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR.
transcription factor target	35715772	hsa-mir-146a	Breast Neoplasms	The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR.
transcription factor target	35715772	hsa-mir-182	Breast Neoplasms	The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR.
transcription factor target	35715580	hsa-mir-212	Glioma	5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells.
lncRNA target	35715546	hsa-mir-155	Testicular Diseases	cereus) as well as the potential role of miR-155/SIRT1/FOXO1 network in DOX-induced testicular injury. Taken together, this study reveals the prophylactic role of these two regimens on male fertility by exhibiting antioxidant, anti-inflammatory, and anti-apoptotic effects against DOX-elicited testicular damage, possibly via modulating miR-155/SIRT1/FOXO1 network.
other	35715331	hsa-mir-370	Triple Negative Breast Neoplasms	5p and miR-940, resulting in increasing the expression of a cohort of oncogenes, thus accelerating TNBC progression.
transcription factor target	35715027	hsa-mir-190	Fanconi Anemia	5p can combine with the 3'UTR of CYP6K2 to suppress its expression.
other	35714798	hsa-mir-37	Multiple Sclerosis	3p, -300, -539, -668, and -323b-5p - were upregulated in MS men, but not women when compared to controls, regardless of conflicting RNA-seq data.
other	35714798	hsa-mir-370c	Multiple Sclerosis	3p, -300, -539, -668, and -323b-5p - were upregulated in MS men, but not women when compared to controls, regardless of conflicting RNA-seq data.
other	35714705	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	5p/LDH-A/lactate/NF-kappaB as an important link between metabolism and NSCLC cells tumorigenesis.
circulation_biomarker_diagnosis_ns	35714213	hsa-mir-451	beta-Thalassemia	CONCLUSION: miRNA-451 has a protective role against CKD development, and low plasma expression levels are associated with CKD in children with beta-TM DOI: 10.52547/ijkd.6756.
transcription factor target	35713801	hsa-mir-126a	Insulin Resistance	We assessed the effects of expression of adipogenic (miR-200c) and metabolic (miR-126a) miRNAs in retroperitoneal white adipose tissue (rWAT) on IR development. CONCLUSIONS: MiR-200 family dysregulation has been related to IR, and miR-126a downregulation could be associated with the improvement in IR observed after a 12-week HSD feeding period.
transcription factor target	35713801	hsa-mir-200	Insulin Resistance	CONCLUSIONS: MiR-200 family dysregulation has been related to IR, and miR-126a downregulation could be associated with the improvement in IR observed after a 12-week HSD feeding period.
other	35713801	hsa-mir-200c	Insulin Resistance	We assessed the effects of expression of adipogenic (miR-200c) and metabolic (miR-126a) miRNAs in retroperitoneal white adipose tissue (rWAT) on IR development.
circulation_biomarker_diagnosis_ns	35713553	hsa-mir-138	Colorectal Neoplasms	5p methylated DNA in plasma as a diagnostic biomarker.
genetics_overexpression_promote	35713481	hsa-mir-200c	Osteosarcoma	MiR-200c overexpression suppressed the role of circCSPP1 in OS cells.
transcription factor target	35713208	hsa-mir-21	Hypertension, Pulmonary	The abnormal expression of RhoA, ROCK2, Rac1 and c-Jun in the lungs of MCT-PH rats was inhibited by E(2) and miR
lncRNA target	35713138	hsa-mir-633	Stomach Neoplasms	CONCLUSION: The low expression level of KAI1 and high expression of miRNA-633 are significantly correlated with the poor overall survival prognosis of malignant melanoma with gastric cancer, to provide a basis for KAI1 and miRNA-633 to become novel molecular targets for malignant melanoma with gastric cancer.
lncRNA target	35713138	hsa-mir-633	Melanoma	CONCLUSION: The low expression level of KAI1 and high expression of miRNA-633 are significantly correlated with the poor overall survival prognosis of malignant melanoma with gastric cancer, to provide a basis for KAI1 and miRNA-633 to become novel molecular targets for malignant melanoma with gastric cancer.
circulation_biomarker_diagnosis_up	35712950	hsa-mir-1	Irritable Bowel Syndrome	RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01).
circulation_biomarker_diagnosis_up	35712950	hsa-mir-29b	Irritable Bowel Syndrome	RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01).
circulation_biomarker_diagnosis_up	35712950	hsa-mir-18a	Irritable Bowel Syndrome	RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01).
circulation_biomarker_diagnosis_up	35712950	hsa-mir-125b	Irritable Bowel Syndrome	RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01).
circulation_biomarker_diagnosis_up	35712950	hsa-mir-155	Irritable Bowel Syndrome	RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01).
transcription factor target	35712865	hsa-mir-372	Diabetes, Gestational	CONCLUSION: Our results further suggested that the downregulations of miR-22 and miR-372 may contribute to GDM through regulating the PI3K/GLUT4 pathway.
transcription factor target	35712865	hsa-mir-22	Diabetes, Gestational	CONCLUSION: Our results further suggested that the downregulations of miR-22 and miR-372 may contribute to GDM through regulating the PI3K/GLUT4 pathway.
lncRNA target	35712514	hsa-mir-140	Endometrial Neoplasms	This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression.
lncRNA target	35712514	hsa-mir-143	Endometrial Neoplasms	This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression.
other	35712508	hsa-mir-221	Carcinoma, Hepatocellular	Mechanistically, ASAP1-IT1 might exert its role in HCC progression, at least in part, by directly interacting with miR3p.
genetics_knock down_promote	35712504	hsa-mir-576	Stomach Neoplasms	CONCLUSION: These findings demonstrated that circDNMT1 knockdown inhibited GC proliferation, migration, invasion and glycolysis through sponging miR
lncRNA target	35712476	hsa-mir-148a	Pancreatic Carcinoma	CONCLUSIONS: Our study suggests that hsa_circ_0046523/miR-148a-3p/PD-L1 regulatory axis mediates PC immunosuppressive microenvironment and these molecules are expected to be new targets for remodeling tumor immune microenvironment of PC.
other	35712349	hsa-mir-205	lung squamous cell carcinoma	The miRNA-mRNA network of miR5p (up) and PTPRM (down) was validated in 30 pairs of LUSC tissues.
other	35712307	hsa-mir-548e	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-548y	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-199a	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-626	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-200a	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-183	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-378h	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-203a	Post-Concussion Syndrome	Among these 13 miRNAs, one (i.e., hsa-miR-203a-5p) was also identified in a prior study, with significantly different expression levels between children with and without PPCS.
other	35712307	hsa-mir-585	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-888	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-95	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-1323	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
other	35712307	hsa-mir-199b	Post-Concussion Syndrome	5p, hsa-miR-199a-3p+hsa-miR-199b-3p).
circulation_biomarker_diagnosis_ns	35712251	hsa-mir-193b	Diabetes Mellitus, Type 2	RESULTS: miR-193b-3p was differentially expressed in type 2 diabetes cases compared to healthy controls (fold change = 2.01, P = 0.006). CONCLUSION: Plasma miR-193b-3p levels increased in type 2 diabetes cases, and TPI1 levels decreased in both plasma and HepG2 cells with increased miR-193b-3p levels, while extracellular lactate levels did not significantly changed.
circulation_biomarker_diagnosis_ns	35712057	hsa-mir-21	Breast Neoplasms	Prognosticating 2-Year Survival Rate of Breast Cancer Patients Through Plasma BACKGROUND: miRNA-21, one of breast cancer (BC) predictive markers, is now gaining cardinal attention from researchers worldwide to evaluate BC patients&#x27; survival rate. We aim to determine the relationship between miRNA-21 and associating factors such as BC staging, other tumor markers, and hormonal status to predict the 2-year survival rate of BC patients.
other	35711934	hsa-mir-185	Intervertebral Disc Degeneration	Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs.
other	35711934	hsa-mir-4306	Intervertebral Disc Degeneration	Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs.
other	35711934	hsa-mir-663a	Intervertebral Disc Degeneration	Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs.
lncRNA target	35711847	hsa-mir-489	Carcinoma, Non-Small-Cell Lung	Conclusion: Taken together, our findings revealed that IL-1beta-induced elevation of lncRNA CHRF aggravated NSCLC through modulation of miR-489/Myd88 axis, which provides a novel direction for NSCLC therapy development.
target gene	35711826	hsa-mir-29b-1	Stomach Neoplasms	The Curcumin Analog Da0324 Inhibits the Proliferation of Gastric Cancer Cells via HOTAIRM1/miR-29b-1-5p/PHLPP1 Axis.
transcription factor target	35711801	hsa-mir-216	Fatty Liver	Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens.
transcription factor target	35711801	hsa-mir-217	Fatty Liver	Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens.
transcription factor target	35711801	hsa-mir-216a	Fatty Liver	Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens.
transcription factor target	35711428	hsa-mir-182	Asthma	In summary, targeting miRNA
exosome	35711020	hsa-mir-626	Mouth Neoplasms	CONCLUSIONS: Our data demonstrate that exosomal miR-626 can facilitate the development of oral cancer by inhibiting the expression of its target NFIB.
circulation_biomarker_diagnosis_down	35710817	hsa-mir-628	Prostatic Neoplasms	5p (miR-628) as a potential biomarker in serum samples from men with prostate cancer (PCa) (Srivastava et al.
circulation_biomarker_prognosis_up	35710767	hsa-mir-141	Gallbladder Neoplasms	Elevated expression of circulating miR-141 in peripheral blood might be a potential novel biomarker for diagnosis and prognosis of GBC patients.
genetics_overexpression_promote	35710754	hsa-mir-107	Colorectal Neoplasms	Overexpression of RUNX3, circMETTL3, or PER3 suppressed while miR-107 mimics promoted, CRC cell proliferation and invasion, as well as tumor growth and metastasis in vivo.
genetics_overexpression_promote	35710537	hsa-mir-140	Postoperative Cognitive Complications	3p or HTR2A overexpression or activation of ERK/Nrf2 pathway elevated neuron viability and diminished their apoptosis and pyroptosis while alleviating Sevo-induced POCD in rats.
genetics_overexpression_promote	35710537	hsa-mir-140	Cognition Disorders	3p or HTR2A overexpression or activation of ERK/Nrf2 pathway elevated neuron viability and diminished their apoptosis and pyroptosis while alleviating Sevo-induced POCD in rats.
transcription factor target	35710416	hsa-mir-188	Azoospermia, Nonobstructive	3p may regulate its target gene ATG7 to participate in autophagy anDual luciferase experiment d affect the development of NOA.
lncRNA target	35710311	hsa-mir-28	Ovarian Neoplasms	CircAHNAK deficiency resulted in the amassing of miR-28, which was elevated in ovarian cancer and promoted cancer cell malignancy. In conclusion, circAHNAK targets miR-28 to upregulate EIF2B5 expression, thus inhibits progression of ovarian cancer by suppressing JAK2/STAT3 signaling pathway.
lncRNA target	35710093	hsa-mir-16	Carcinoma, Hepatocellular	Thus, we revealed that circPTTG1IP is a novel tumor suppresser circRNA in HCC and that a low circPTTG1IP level promotes HCC development via the miR5p/RNF125/JAK1 axis.
other	35710089	hsa-mir-677	Lung Diseases	Guinea pigs showed no obvious pathological changes and less severe lung lesions in bta-miR-677 agomir treated group at 7 dpi.
genetics_overexpression_promote	35710089	hsa-mir-677	Cataract, posterior polar, 3	Bta-miR-677 overexpression promoted type I interferon (IFN-I) and IFN-stimulated genes (ISGs) production, thereby inhibiting CPIV3 replication, while bta-miR-677 inhibitor suppressed the antiviral innate immune response to promoted viral replication in MDBK cells.
circulation_biomarker_diagnosis_ns	35709892	hsa-mir-132	Alzheimer Disease	Finally, using peripheral blood samples of human study participants, we found that the miR
transcription factor target	35708762	hsa-mir-125b	Diabetic Angiopathies	Through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, high glucose induced miR-125b-5p, which in turn targeted SIRT7 in myeloid cells and was directly associated with coronary calcification.
genetics_overexpression_promote	35708677	hsa-mir-194	Stomach Neoplasms	5p overexpression attenuated the malignant phenotypes of GC cells.
exosome	35708510	hsa-mir-31	Uterine Cervical Neoplasms	The aim of this study is to investigate if extracellular vesicles (EVs) from bone marrow mesenchymal stem cells (BMSCs) deliver microRNA (miR)
other	35708203	hsa-mir-126	Dengue	CmiR3p expression during febrile and convalescent phases in dengue-infected patients was significantly lower than AFI (p < 0.05).
genetics_knock down_suppress	35708150	hsa-mir-29a	Inflammation	Collectively, these data demonstrated that NEAT1 knockdown inhibited hypoxia-induced cell apoptosis, inflammation, and fibrosis by targeting the miR-29a/NFATc3 axis in PF, suggesting that NEAT1 might be a potential therapeutic target for relieving PF progression.
genetics_knock down_suppress	35708150	hsa-mir-29a	Diabetic Nephropathies	Collectively, these data demonstrated that NEAT1 knockdown inhibited hypoxia-induced cell apoptosis, inflammation, and fibrosis by targeting the miR-29a/NFATc3 axis in PF, suggesting that NEAT1 might be a potential therapeutic target for relieving PF progression.
genetics_overexpression_promote	35707935	hsa-mir-1288	Squamous Cell Carcinoma of Head and Neck	3p, whose upregulation promoted OSCC progression and eliminated the effects of overexpression of hsa_circ_0096042 on OSCC cells.
genetics_GWAS	35707883	hsa-mir-21	Lupus Erythematosus, Systemic	This study evaluated the association between the genetic variants of microRNA-21 (miR-21) and microRNA-155 (miR-155) and SLE.
genetics_GWAS	35707883	hsa-mir-155	Lupus Erythematosus, Systemic	This study evaluated the association between the genetic variants of microRNA-21 (miR-21) and microRNA-155 (miR-155) and SLE.
lncRNA target	35707849	hsa-mir-23a	Myasthenia Gravis	CONCLUSION: Collectively, our results indicate that GAS5 can regulate the Th17/Treg balance by targeting miR-23a expression, providing a scientific basis for clinical therapeutic development for MG.
transcription factor target	35707845	hsa-mir-20a	Osteoarthritis	In conclusion, miR-20a-5p facilitates BMSC chondrogenic differentiation and contributes to cartilage repair in OA by suppressing Map3k2.
epigenetics	35707350	hsa-mir-23	Multiple Myeloma	Hypermethylation of the Promoter Region of miR-23 Enhances the Metastasis and Proliferation of Multiple Myeloma Cells via the Aberrant Expression of uPA.
epigenetics	35706811	hsa-mir-657	Carcinoma, Hepatocellular	ROC curve analysis revealed that the mean methylation level of the miR-657 promoter region could distinguish cancerous tissues from paired normal tissues of HCC patients (area under the curve: 0.847, P<0.001).
exosome	35706810	hsa-mir-142	Liver Neoplasms	HBV-positive liver cancer cell exosomal miR-142-3p can promote the progression of liver cancer by inducing iron death of M1-type macrophages.
circRNA target	35706804	hsa-mir-1290	Glioblastoma	Hsa-miR-1248 and hsa-miR-1290 were up regulated and related to glioblastoma poor prognosis. In this network, hsa_circ_0001073, hsa_circ_0070700, hsa_circ_0000219, hsa-miR-1248, hsa-miR-1290, and RNF11 may have the potential being emerging glioblastoma therapeutic targets.
circRNA target	35706804	hsa-mir-1248	Glioblastoma	Hsa-miR-1248 and hsa-miR-1290 were up regulated and related to glioblastoma poor prognosis. In this network, hsa_circ_0001073, hsa_circ_0070700, hsa_circ_0000219, hsa-miR-1248, hsa-miR-1290, and RNF11 may have the potential being emerging glioblastoma therapeutic targets.
circulation_biomarker_diagnosis_ns	35706801	hsa-mir-148b	Urinary Bladder Neoplasms	5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs.
circulation_biomarker_diagnosis_ns	35706801	hsa-mir-132	Urinary Bladder Neoplasms	5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs.
circulation_biomarker_diagnosis_ns	35706801	hsa-mir-7	Urinary Bladder Neoplasms	5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs.
target gene	35706791	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	LncRNA OXCT1-AS1 promotes the proliferation of non-small cell lung cancer cells by targeting the miR-195/CCNE1 axis.
other	35706417	hsa-mir-383	Venous Thrombosis	Therefore, the lncRNA-MALAT1/miR5p/BCL2L11 axis may be effective for DVT treatment.
lncRNA target	35706403	hsa-mir-1225	Keloid	Therefore, our results show that hsa_circ_0057452 promotes keloid progression by targeting miR
genetics_overexpression_suppress	35706019	hsa-mir-485	Mouth Neoplasms	5p inhibited OSCC sphere formation and caused sensitization of cancer cells towards cisplatin and carboplatin, which could be significantly rescued by KRT17 overexpression.
circulation_biomarker_diagnosis_up	35706002	hsa-mir-613	Carcinoma, Hepatocellular	BACKGROUND: This study aimed to explore the specific pathogenesis of lncRNA MALAT1 promoting the invasion and metastasis of hepatocellular carcinoma (HCC) through peripheral blood vessels by regulating the expression of miRNA-613 molecule.
circulation_biomarker_diagnosis_up	35705894	hsa-mir-200a	Hypertension	High serum miR-200a-3p expression in HDCP patients was associated with increased adverse pregnancy outcomes.
lncRNA target	35705830	hsa-mir-188	Vasculitis	5p suppressed Dox-induced vascular inflammation in vitro.
circulation_biomarker_diagnosis_ns	35705319	hsa-mir-1229	Cardiomyopathies	5p inhibitor under serum-EVs treatment reduced the protective effect of serum-EVs on myocardial cell injury, decreased cell proliferation, increased the number of apoptotic cells, and increased myocardial injury indicator concentration.
genetics_knock down_promote	35705019	hsa-mir-30	Uterine Cervical Neoplasms	CONCLUSIONS: BCYRN1 knockdown could disrupt the DDP-resistance of CC cells through upregulating miR
other	35704723	hsa-mir-29b	COVID-19	5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases.
other	35704723	hsa-mir-6501	COVID-19	5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases.
other	35704723	hsa-mir-5695	COVID-19	5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases.
genetics_GWAS	35704669	hsa-mir-1	Lumbar Disc Herniation	Our results shown that in the Chinese Han population, the MIR31HG polymorphism rs10965059 was involved in a risk to symptomatic LDH, which provides a scientific basis for early screening, prevention, diagnosis and treatment of local LDH high-risk populations.
other	35704638	hsa-mir-33a	Esophageal Neoplasms	ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC.
other	35704638	hsa-mir-1	Esophageal Neoplasms	ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC.
other	35704638	hsa-mir-133a	Esophageal Neoplasms	ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC.
other	35704597	hsa-mir-199	Diabetes Mellitus	Further studies are needed to confirm Klotho and hsa-miR5p as markers for T2DM complications.
transcription factor target	35704246	hsa-mir-375	Plaque, Atherosclerotic	CONCLUSION: METTL3-mediated m(6)A modification promoted VSMC phenotype transformation and made AS plaques more vulnerable via the miR3p/PDK1 axis.
genetics_overexpression_promote	35704145	hsa-mir-25	Sepsis-Associated Encephalopathy	3p overexpression attenuated the activation of microglia in SAE by inhibiting the NLRP3/IL-1beta/IL-18 axis by directly targeting TLR4, suggesting that miR
other	35703738	hsa-mir-34a	Myocardial Reperfusion Injury	This study was designed to investigate whether microRNA-34a (miR-34a) influences cardiac I/R or hypoxia/reoxygenation (H/R) injury by regulating the mitochondrial apoptotic pathway from oxidative injury.In vivo, myocardial infarction size was examined by Evan blue/TTC staining.
lncRNA target	35703693	hsa-mir-589	Spinal Cord Injuries	In summary, these data revealed that KCNQ1OT1 promoted inflammatory response and apoptosis of microglia by regulating the miR5p/NPTN axis after SCI, which may offer a novel promising therapeutic target for SCI.
circulation_biomarker_diagnosis_ns	35703473	hsa-mir-122	Liver Diseases	Serum concentrations of microRNA (miR)-122 have been shown in humans, dogs and rodents to be a sensitive and specific biomarker for liver injury. This work highlights the potential diagnostic utility of miR-122 as a biomarker of liver damage in cats and encourages further investigation to determine the sensitivity and specificity of miR-122 as a biomarker of hepatocellular injury in this species.
circulation_biomarker_diagnosis_ns	35703473	hsa-mir-122	Chemical and Drug Induced Liver Injury	Serum concentrations of microRNA (miR)-122 have been shown in humans, dogs and rodents to be a sensitive and specific biomarker for liver injury. This work highlights the potential diagnostic utility of miR-122 as a biomarker of liver damage in cats and encourages further investigation to determine the sensitivity and specificity of miR-122 as a biomarker of hepatocellular injury in this species.
lncRNA target	35703357	hsa-mir-205	Melanoma	Cell Counting Kit8 and flow cytometry assays indicated the suppression of proliferation of melanoma cells following inhibition of MIR205HG expression.
genetics_overexpression_promote	35703312	hsa-mir-138	Triple Negative Breast Neoplasms	Decreased proliferation rate of TNBC cells was observed after overexpression of MT1JP and miR-138.
exosome	35703190	hsa-mir-490	Esophageal Squamous Cell Carcinoma	In conclusion, exosomal circFNDC3B drove ESCC progression via regulating the miR5p/TXNRD1 axis.AbbreviationsEC: esophageal cancer; ESCC: esophageal squamous cell carcinoma; circRNA: circular RNA; WB: western blot; TEM: transmission electron microscopy; NTA: nanoparticle tracking analysis; TXNRD1: thioredoxin reductase 1; IHC: immunohistochemistry; RT-qPCR: reverse transcription-polymerase quantitative chain reaction; GLUT1: glucose transport protein type 1; LDHA: lactate dehydrogenase A.
genetics_overexpression_promote	35702784	hsa-mir-1202	Lung Neoplasms	CERS6-AS1 silencing or miR-1202 overexpression reversed the impacts induced by IGF2BP3 on lung cancer.
transcription factor target	35702326	hsa-mir-5682	Dmd-Associated Dilated Cardiomyopathy	Additionally, visualization of the interactions between miRNAs and the hub genes revealed that hsa-miR-5682 and hsa-miR-4500 interacted with both COL3A1 and COL1A2, and thus these miRNAs might play roles in DCM. CONCLUSION: COL1A2 and COL3A1 and their targeting miRNAs, hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM, which are closely related to the IL-17 signaling pathway and acute inflammatory response.
transcription factor target	35702326	hsa-mir-4500	Dmd-Associated Dilated Cardiomyopathy	Additionally, visualization of the interactions between miRNAs and the hub genes revealed that hsa-miR-5682 and hsa-miR-4500 interacted with both COL3A1 and COL1A2, and thus these miRNAs might play roles in DCM. CONCLUSION: COL1A2 and COL3A1 and their targeting miRNAs, hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM, which are closely related to the IL-17 signaling pathway and acute inflammatory response.
other	35702258	hsa-mir-105	Carcinoma, Hepatocellular	CONCLUSIONS: Our findings could provide insights into the selection of novel LINC00261/MiR105-5p/SELL pathway which is associated with overall survival and may impact on efficacy of immunotherapy in HCC.
target gene	35702180	hsa-mir-144	Colorectal Neoplasms	Dysregulation of MiR-144-5p/RNF187 Axis Contributes To the Progression of Colorectal Cancer.
transcription factor target	35702088	hsa-mir-135a	Arthritis, Rheumatoid	Moreover, STAT6 was involved in the regulation of miR-135a-5p on cell growth, apoptosis and inflammatory response of RA FLSs. CONCLUSION: miR-135a-5p/STAT6 is a potential novel therapeutic target for RA treatment.
other	35702084	hsa-mir-129	Glioma	CONCLUSION: LINC00665 functions as an oncogenic lncRNA in glioma, to accelerate glioma progression by modulating miR5p and increasing HMGB1 expression.
lncRNA target	35702078	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	CONCLUSION: In our study, we elaborated that LncRNA PCAT7 could promote the development of NSCLC cells by accelerating cell cycle via miR
transcription factor target	35701740	hsa-mir-335	Corneal Neovascularization	CONCLUSIONS: In general, our data confirmed that miR-335 facilitated the process of CRNV by targeting EGFR.
circulation_biomarker_diagnosis_up	35700796	hsa-mir-221	Osteoporosis	METHODS: Serum from patients with postmenopausal osteoporosis and healthy controls was collected for determination of miR
circulation_biomarker_diagnosis_ns	35700789	hsa-mir-1225	familial temporal lobe epilepsy 3	CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR
circulation_biomarker_diagnosis_ns	35700789	hsa-mir-629	familial temporal lobe epilepsy 3	CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR
circulation_biomarker_diagnosis_ns	35700789	hsa-mir-1202	familial temporal lobe epilepsy 3	CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR
other	35700742	hsa-mir-27a	Prostatic Neoplasms	These findings offer the possibility of employing the miR-124 and miR-27a-3p as therapeutic agents for prostate cancer treatment.
other	35700742	hsa-mir-124	Prostatic Neoplasms	These findings offer the possibility of employing the miR-124 and miR-27a-3p as therapeutic agents for prostate cancer treatment.
genetics_knock down_promote	35700738	hsa-mir-690	Diabetic Nephropathies	KC-specific KO of miR-690 promotes NASH pathogenesis.
genetics_knock down_promote	35700738	hsa-mir-690	non-alcoholic steatohepatitis	KC-specific KO of miR-690 promotes NASH pathogenesis.
other	35700709	hsa-mir-181a	Carcinoma, Non-Small-Cell Lung	miR-181a-5p restrains non-small cell lung cancer cell invasion and migration by regulating the GTSE1/p53/NF-κB axis.
genetics_overexpression_suppress	35700579	hsa-mir-340	Laryngeal Neoplasms	5p overexpression reduced lncRNA NEAT1 stability via binding to lncRNA NEAT1, which declined lncRNA NEAT1 expression and reduced the binding of lncRNA NEAT1 to HSF1 to further inhibit MMP11 transcription, thus repressing LC cell proliferation and invasion.
lncRNA target	35700516	hsa-mir-485	Nasopharyngeal Carcinoma	3p/SOX9, indicating that circSOX9 can be used as a potential therapeutic target and predictive marker for nasopharyngeal carcinoma.
circulation_biomarker_prognosis_down	35700456	hsa-mir-15a	Subarachnoid Hemorrhage	The expression of miR-15a was significantly repressed in the peripheral blood and CSF of SAH patients carrying the AT allele when compared with that in patients carrying the AA allele. CONCLUSIONS: The findings demonstrated that the presence of the minor allele of rs17427875 in lncRNA-HOXA11-AS could increase the expression level of lncRNA-HOXA11-AS, thus elevating the expression level of STAT3 via down-regulating miR-15a, and increased STAT3 expression could aggravate inflammation to cause poor prognosis of SAH.
other	35700382	hsa-mir-375	Neoplasms, Germ Cell and Embryonal	Statistically significant and high expression of microRNA375 attributable for yolk sac tumors and immature teratomas.
genetics_overexpression_promote	35699870	hsa-mir-29b	Myocardial Infarction	ADAMTS16 overexpression accelerated MI in rats, and ADAMTS16 upregulation reversed the protective effects of miR-29b-3p upregulation on MI rats.
other	35699802	hsa-mir-3551	Spinal Cord Injuries	Our study revealed that circHecw1 regulates SCI neuronal cell inflammation imbalance by regulating the miR3p/LRRTM1 signaling.
lncRNA target	35699307	hsa-mir-21	Carcinoma, Pancreatic Ductal	Here we specifically evaluate the capability of PSD to enhance RNA nanomedicine delivery, using a NP carrying an inhibitor of miR5P, a PDAC oncomiR.
transcription factor target	35699095	hsa-mir-665	Carcinoma, Hepatocellular	It also inhibited miR-665 expression in HCC cells. We further observed that sevoflurane inhibited HCC metastasis via miR-665.
circulation_biomarker_diagnosis_ns	35698951	hsa-mir-20	Lung Diseases	CONCLUSION: Our findings demonstrate that miR-320c inhibits SERPINA1 expression in a hepatic cell line and its levels in blood are associated with lung disease in a cohort of patients with different AAT serum levels.
circulation_biomarker_diagnosis_ns	35698951	hsa-mir-320c	Lung Diseases	CONCLUSION: Our findings demonstrate that miR-320c inhibits SERPINA1 expression in a hepatic cell line and its levels in blood are associated with lung disease in a cohort of patients with different AAT serum levels.
circRNA target	35698314	hsa-mir-1290	Pre-Eclampsia	CONCLUSION: Hsa_circ_000872 can regulate LHX6 by adsorbing miR-1290 to inhibit PE progression, thus establishing hsa_circ_000872 as a potential target for predicting and treating PE.
other	35698305	hsa-mir-4262	Colorectal Neoplasms	CONCLUSION: Hsa_circ_0001550 facilitated CRC progression by binding to miR-4262 to positively regulate NUCKS1 abundance.
other	35697826	hsa-mir-125a	Chronic Rhinosinusitis With Nasal Polyps 	In summary, the constructed novel MIAT/miR-125a/IRF4 axis may play a critical role in the development and progression of CRSwNP.
other	35697826	hsa-mir-125a	Nasal Polyps	In summary, the constructed novel MIAT/miR-125a/IRF4 axis may play a critical role in the development and progression of CRSwNP.
other	35697130	hsa-mir-499	Myocardial Ischemia	Further miRNA microarray and bioinformatics analysis revealed that miR-499 was significantly down-regulated, while PTEN was remarkably upregulated after Tan IIA administration post-MI.
lncRNA target	35696757	hsa-mir-363	Glioma	The changes in the target microRNA-363 sequence were standardized to identify glioma.
lncRNA target	35696408	hsa-mir-212	Diarrhea, Bacterial	coli F18 susceptibility via histone H4 modifications or miR-212/FUT3 axis, which will provide theoretical guidance to develop novel strategies for combating bacterial diarrhea in piglets.
transcription factor target	35696095	hsa-mir-143	Diabetes Mellitus	In conclusion, acarbose reduces VSMC migration and proliferation via upregulating miR-143 to inhibit Ras-related signaling, and potentially prevention of atherosclerosis.
transcription factor target	35696058	hsa-mir-17	Colonic Neoplasms	5p facilitated malignant progression of colon cancer through targeting CADM2 at a post-transcriptional level.
genetics_overexpression_promote	35695668	hsa-mir-1179	Pancreatic Carcinoma	Overexpression of both GAS8-AS1 and miR-1179 inhibited PC cell migration and invasion.
other	35695667	hsa-mir-671	Carcinoma, Hepatocellular	5p fostered the proliferation, migration and invasion of HCC cells by restraining ALDH2.
other	35695665	hsa-mir-21	Uterine Cervical Neoplasms	CCK-8 cell proliferation analysis and cell apoptosis analysis were applied to study the roles of MCM3AP-AS1, miR-21, and PTEN in regulating cell proliferation and apoptosis in CSCC. Therefore, MCM3AP-AS1 may regulate the miR-21/PTEN axis to regulate CSCC cell proliferation and apoptosis.
genetics_overexpression_promote	35695664	hsa-mir-505	Endometrial Neoplasms	In EC cells, circRIMS overexpression decreased miR-505 expression and increased miR-505 gene methylation.
genetics_knock down_promote	35695663	hsa-mir-137	Stomach Neoplasms	The gain/loss-of-function indicates that miR-137 regulates the proliferation, apoptosis, migration and epithelial-mesenchymal transition of GC cells.
genetics_knock down_promote	35695651	hsa-mir-29b	Glioma	circRNA_104948 could regulate the proliferation/apoptosis of astrocytes through miR-29b-3p/DNMT3B/MTSS1 signaling, and the biological behavior changes induced by glioma-Exo were reversed by miR-29b-3p mimics; upregulated cell growth caused by miR-29b-3p inhibitors was abrogated by the knockdown of DNMT3B; the effects induced by miR-29b-3p mimics were abolished by the overexpression of DNMT3B. Our findings revealed the important roles of circRNA_104948 on the development of glioma, and circRNA_104948/miR-29b-3p/MTSS1/DNMT3B pathway may be a potential candidate for the target therapy of glioma patients.
genetics_overexpression_promote	35695612	hsa-mir-1285	Stomach Neoplasms	Overexpressing miR-1285 restrained GC cell multiplication and accelerated apoptosis, whereas suppressing miR-1285 facilitated cell growth and restrained apoptosis.
circulation_biomarker_diagnosis_up	35695610	hsa-mir-21	Leukemia, Myeloid, Acute	CONCLUSION: In conclusion, SCIRT was downregulated in AML and it sponged miR-21 in cytoplasm to increase the chemosensitivity to Dox.
genetics_knock down_suppress	35695608	hsa-mir-98	Breast Neoplasms	In addition, LINC01287 knockdown and miR-98 overexpression significantly stagnated progression of BC cells.
genetics_overexpression_promote	35695605	hsa-mir-124	Carcinoma, Hepatocellular	In addition, miR-124 overexpression decreased HCC cell proliferation, while DSCAM-AS1 increased HCC cell proliferation.
other	35695486	hsa-mir-532	Mesothelioma, Malignant	5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively.
other	35695486	hsa-mir-29c	Mesothelioma, Malignant	5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively.
other	35695486	hsa-mir-484	Mesothelioma, Malignant	5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively.
other	35695486	hsa-mir-125a	Mesothelioma, Malignant	5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively.
other	35695486	hsa-mir-20a	Mesothelioma, Malignant	5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively.
circulation_biomarker_diagnosis_ns	35695478	hsa-mir-375	Prostatic Neoplasms	Here we describe how a ligation-free version of this technique performed in a single tube can be used to improve the limit of detection for microRNA-375, an important blood biomarker for prostate cancer.
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	Retinal Diseases	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	osteogenesis imperfecta type 1	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	Retinopathy of Prematurity	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	Hypertrophy, Right Ventricular	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	Benign Paroxysmal Positional Vertigo	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
circulation_biomarker_diagnosis_up	35695424	hsa-mir-17	Retinal Neovascularization	5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol
other	35695264	hsa-mir-9	Heart Arrest	3p are peaking 48 hours following cardiac arrest.
lncRNA target	35695254	hsa-mir-448	Colorectal Neoplasms	Knocking down of nuclear paraspeckle assembly transcript 1 can suppress colorectal cancer proliferation and invasion, and caused a reduction of ZEB1 expression and an increase of miR-448 expression. Conclusion: Our result demonstrated that long noncoding RNA nuclear paraspeckle assembly transcript 1 promotes proliferation and invasion of colorectal cancer by targeting miR-448 to promote the expression of ZEB1, which may play a significant role in the tumorigenesis of colorectal cancer.
transcription factor target	35695083	hsa-mir-21	Hypoxia-Ischemia, Brain	CONCLUSION: DZ enhanced miR-21 level and inhibited PDCD4 level via PI3K/AKT pathway to resisted HIE.
circulation_biomarker_prognosis_up	35694659	hsa-mir-200b	Shock, Cardiogenic	Future studies are required to delineate the impact of serum miRNA-200b levels as a prognostic marker in patients with acute CS and pVAD unloading.
exosome	35693981	hsa-mir-579	Osteosarcoma	Additionally, the promoting function of exosomal CTCF-mediated IGF2-AS/miR
other	35693941	hsa-mir-101	Carcinoma, Hepatocellular	Then, we constructed a ceRNA network consisting of MELK, miR3p, and two lncRNAs (SNHG1 and SNHG6) after evaluating the expression and impact on prognosis in HCC of these RNAs.
other	35693719	hsa-mir-142	Kidney Neoplasms	As a natural vector of miR3p, RCSC-sEVs return to the kidney cells and interfered with the expression of ERp44, inducing ERS and ultimately leading to apoptosis of normal renal cells and renal function impairment.
other	35693619	hsa-mir-145	Cardiomegaly	In hypertrophic cardiomyocytes, after up-regulating the expression of miR-145, the relative messenger ribonucleic acid (mRNA) and protein expressions of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) induced by PE decreased. CONCLUSIONS: The lncRNA ROR can promote the expression of HAX-1 by competitive binding with miR-145, so as to promote the pathophysiological process of myocardial hypertrophy.
genetics_GWAS	35693293	hsa-mir-494	Carcinoma, Non-Small-Cell Lung	3p was significantly elevated in plasma sampled at disease progression compared to plasma sampled at treatment baseline in a cohort of 21 EGFR T790M-mutation positive NSCLC patients receiving osimertinib.
other	35693096	hsa-mir-137	Stomach Neoplasms	In addition, according to the lncRNA/miRNA/mRNA regulatory relationships among the 43 ceRNAs, we identified four axes that might play important roles in the progression of GC and investigated the potential mechanism of the most promising axis (POU6F2-AS2/hsa-mir-137/OPCML) in promoting the proliferation and invasiveness of GC.
circRNA target	35693080	hsa-mir-491	Esophageal Squamous Cell Carcinoma	In conclusion, hsa_circ_0001741 promotes ESCC stemness, invasion, and migration by sponging tumor suppressor miR5p to upregulate NOTCH3 expression.
other	35693013	hsa-mir-17	Adenocarcinoma of Lung	According to the results of our study, the ferroptosis-related ceRNA HCP5 /hsa-miR5p/HOXA7 axis may contribute to the development of BNM in LUAD patients.
other	35693013	hsa-mir-17	Thyroid Cancer, Papillary	According to the results of our study, the ferroptosis-related ceRNA HCP5 /hsa-miR5p/HOXA7 axis may contribute to the development of BNM in LUAD patients.
circulation_biomarker_diagnosis_up	35692876	hsa-mir-144	Crohn Disease	These findings suggested that circulating exosomal miR
target gene	35692754	hsa-mir-485	Osteosarcoma	Long Intergenic Noncoding RNA00265 Enhances Cell Viability and Metastasis via Targeting miR-485-5p/USP22 Axis in Osteosarcoma.
other	35692583	hsa-mir-28	lung squamous cell carcinoma	3p/IL1B regulatory axis for LUSC.
circulation_biomarker_diagnosis_up	35692504	hsa-mir-635	Stomach Neoplasms	In addition, AC restrained gastric cancer proliferation and migration ability and induced endoplasmic reticulum stress by upregulating miR-635 expression. CONCLUSION: AC suppressed gastric cancer progression and induced endoplasmic reticulum stress via the miR-635/HMGA1 axis, providing a valuable drug against gastric cancer.
genetics_overexpression_suppress	35692501	hsa-mir-214	Squamous Cell Carcinoma of Head and Neck	Moreover, to further determine the impacts of miR-214 and ULK1 on oral cancer cell growth after chemotherapy, the two were overexpressed or silenced in CAL-27 cells after transfection.
other	35692373	hsa-mir-22	Iron Metabolism Disorders	The current study was aimed at exploring the function and mechanism of MIR22HG in I/R injury.
genetics_knock down_suppress	35692373	hsa-mir-9	Cardiomyopathies	In summary, MIR22HG knockdown alleviates myocardial injury through the miR3p/SH2B3 axis.
genetics_knock down_suppress	35692373	hsa-mir-9	Myocardial Infarction	In summary, MIR22HG knockdown alleviates myocardial injury through the miR
genetics_knock down_promote	35692373	hsa-mir-22	Myocardial Infarction	In summary, MIR22HG knockdown alleviates myocardial injury through the miR
genetics_knock down_suppress	35692373	hsa-mir-22	Cardiomyopathies	In summary, MIR22HG knockdown alleviates myocardial injury through the miR3p/SH2B3 axis.
exosome	35691812	hsa-mir-603	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
exosome	35691812	hsa-mir-548ad	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
exosome	35691812	hsa-mir-122	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
exosome	35691812	hsa-mir-215	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
exosome	35691812	hsa-mir-4477a	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
exosome	35691812	hsa-mir-583	Pancreatitis	CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR
lncRNA target	35691339	hsa-mir-134	Osteoporosis	5p/Itgb1/MAPK pathway might be a potential target for osteoporosis therapy.
lncRNA target	35691099	hsa-mir-194	Colonic Neoplasms	3p could overcome DCT resistance in CC cells through negatively regulating KLK10.
circulation_biomarker_prognosis_ns	35691029	hsa-mir-21	Primary Gastrointestinal Diffuse Large B-Cell Lymphoma 	RESULTS: Compared with healthy controls, serum miR-21 levels were significantly elevated in the PGI-DLBCL patients (n=156).
exosome	35690961	hsa-mir-7	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-181a	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-9	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-642	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-4417	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-125b	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
exosome	35690961	hsa-mir-455	Small Cell Lung Carcinoma	The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content.
circulation_biomarker_prognosis_up	35690861	hsa-mir-654	Heart Failure	5p for the first time as a novel biomarker of HF, but also developed a novel 2-circulating miRNA model with promising potentials for diagnosis and prognosis of HF patients, and in association with therapeutic effects as well.
lncRNA target	35690612	hsa-mir-27a	Squamous Cell Carcinoma of Head and Neck	Mechanistically, a dual-luciferase reporter assay, FISH, RIP, RNA pull-down, RNA-seq, and western blot experiments were employed and found that circRFWD3 served as a miRNAs sponge for miR-27a/27b, leading to the upregulation of PPARgamma, and then promoted HNSCC metastasis via NF-kappaB/MMP13 pathway.
circulation_biomarker_diagnosis_ns	35690607	hsa-mir-96	Scoliosis, Adolescent	Our results showed significantly higher plasma levels of miR
circulation_biomarker_diagnosis_ns	35690607	hsa-mir-96	idiopathic scoliosis	Our results showed significantly higher plasma levels of miR
circulation_biomarker_diagnosis_ns	35690607	hsa-mir-96	Bone Diseases, Metabolic	Our results showed significantly higher plasma levels of miR
other	35690602	hsa-mir-129	Migraine Disorders	Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection.
other	35690602	hsa-mir-24	Migraine Disorders	Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection.
other	35690602	hsa-mir-19a	Migraine Disorders	Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection.
lncRNA target	35690295	hsa-mir-184	Macular Degeneration	Taken together, miR-184 attenuates retinal cell damage induced by severe AMD pathologies through suppressing hypoxia, angiogenesis and apoptosis.
genetics_GWAS	35690283	hsa-mir-149	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Similarly, miR-149 (rs2292832) was positively associated with ALL according to the codominant and dominant genetic models.
transcription factor target	35690236	hsa-mir-146a	Diabetes Mellitus	Luminex assay was performed on conditioned media at 6- and 20-h post-wounding in miR-146a mimic/inhibitor transfected normal and diabetic cultured LECs.
circulation_biomarker_diagnosis_ns	35690140	hsa-mir-493	Segmental Vitiligo	Hence, circulating exosomal miR
exosome	35689956	hsa-mir-129	Pulmonary Fibrosis	Furthermore, the in vivo experiment confirmed that the exosomes of M2 macrophages could carry miR
lncRNA target	35689751	hsa-mir-148b	Adrenocorticotropic hormone deficiency	The expression levels of circ_0021001 and GREM1 were increased, and that of miR-148b-3p was decreased in IA tissues and HUASMCs. Circ_0021001 silencing could suppress cell growth and induce apoptosis of HUASMCs partially through modulating the miR-148b-3p/GREM1, presented circ_0021001 as a promising therapeutic target for IA.
other	35689735	hsa-mir-146a	Fetal Growth Retardation	The alleles related to reduced miRNA-146a (C) and ADIPOQ (A) activity showed increased frequency in SGA. CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk.
other	35689735	hsa-mir-146a	Obesity	CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk.
lncRNA target	35689735	hsa-mir-146a	Polycystic Ovary Syndrome	The mature miR-146a targets 319 genes, been the CXCR4, TMEM167A and IF144L common targets and contributes to PCOS. CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk.
circRNA target	35689709	hsa-mir-24	Polycystic Ovary Syndrome	3p/MAP2K6, which provided a promising therapeutic target for PCOS.
lncRNA target	35689522	hsa-mir-199a	Squamous Cell Carcinoma of Head and Neck	Importantly, CUR-NEs cloud effectively counteract the influence on cell proliferation of OSCC cells and the proliferative phases of cell cycle caused by miR-199a inhibitor a time-dependent manner.
exosome	35689381	hsa-mir-124	Parkinson Disease	Our findings reveal a novel promising therapeutic application of small extracellular vesicles as delivery agents for miR3p in the context of Parkinson's disease.
other	35689264	hsa-mir-181a	Osteoarthritis	CONCLUSIONS: Conclusively, Gm37494 elevated GABRA1 expression by binding to miR-181a-5p, thus ameliorating OA-induced chondrocyte damage.
other	35689189	hsa-mir-485	Reperfusion Injury, Cerebral Ischemia	5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE.
other	35689189	hsa-mir-485	Sepsis-Associated Encephalopathy	5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE.
other	35689189	hsa-mir-1197	Reperfusion Injury, Cerebral Ischemia	5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE.
other	35689189	hsa-mir-1197	Sepsis-Associated Encephalopathy	5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE.
genetics_overexpression_promote	35688263	hsa-mir-129-2	Triple Negative Breast Neoplasms	DARS-AS1 overexpression significantly enhanced the migration and invasion of TNBC tumors by inhibiting miR2-3p and upregulated CDK1 to activate the NF-kappaB/STAT3 signaling pathway both in vitro and in vivo.
circRNA target	35687903	hsa-mir-24	Abortion, Habitual	3p/TJP1 axis is involved in the occurrence and progression of RSA and may be a promising therapeutic target in RSA.
circRNA target	35687899	hsa-mir-1276	Ovarian Neoplasms	CONCLUSION: Circ_0063804 promoted OC cells proliferation and resistance to cisplatin by enhancing CLU expression via sponging miR-1276.
genetics_overexpression_promote	35687898	hsa-mir-122	Urinary Bladder Neoplasms	We picked up miRNA miR-3122, which substantially interacted with NEAT1.1, and found that histone H3K79me3 was reduced in bladder cancer T24, BIU-87 and EJ-1 cells after miR-3122 overexpression, and rescued by NEAT1.1 additional compensation. Taken together, we demonstrated that NEAT1.1 weakened the effect of miR-3122 on H3K79me3 suppression in bladder cancer.
exosome	35687301	hsa-mir-34a	Insulin Resistance	The in vitro and in vivo functional experiments revealed that MSC secreted exosomal miR-34a-5p and ameliorated IIRI through METTL3/IGF2BP3-mediated m(6)A modification of pre-miR-34A.
genetics_overexpression_promote	35687299	hsa-mir-544	Inflammation	Also, either miR3p inhibition or TLR4 overexpression weakened circ-Ncam2 silencing-mediated effects on LPS-induced BV2 cell activation and inflammation.
lncRNA target	35687299	hsa-mir-544	Spinal Cord Injuries	circ-Ncam2 silencing lowered LPS-induced microglia activation and neuronal apoptosis via blocking the TLR4/NF-kappaB pathway through acting as a miR3p sponge, suggesting that circ-Ncam2 may be involved in secondary SCI.
other	35687145	hsa-mir-339	Nephritis	The purpose of this study was to investigate the role of miR5p in lipopolysaccharide (LPS)-induced nephritis injury in vitro.
other	35687145	hsa-mir-339	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	However, the role of miR5p in CGN remains unclear.
genetics_GWAS	35687049	hsa-mir-616	Squamous Cell Carcinoma of Head and Neck	In summary, our findings revealed that the risk SNP rs3113503 G > C in LINC01614 altered the binding to miR3p, which led to increased LINC01614 expression and promoted HNSCC progression by activating the PI3K/AKT signaling pathway.
lncRNA target	35686740	hsa-mir-944	Osteoarthritis	In our study, LEMD1-AS1 and post-GPI attachment to protein (PGAP1) were lowly expressed, but miR-944 was highly expressed both in OA tissues and in Lipopolysaccharide (LPS) -treated chondrocytes detected by qRT-PCR. To conclude, the LEMD1-AS1/miR-944/PGAP1 axis may be a novel therapeutic candidate to target in OA treatment.
genetics_knock down_suppress	35686503	hsa-mir-129-2	Stomach Neoplasms	CONCLUSIONS: Circ_0081143 knockdown weakened DR resistance and blocked the development of DR-resistant GC by regulating the miR
lncRNA target	35686454	hsa-mir-96	Myocardial Infarction	Collectively, USP7 upregulated SOX9 expression through deubiquitination, and SOX9 suppressed miR
lncRNA target	35686454	hsa-mir-96	Sepsis	Collectively, USP7 upregulated SOX9 expression through deubiquitination, and SOX9 suppressed miR
other	35686336	hsa-mir-218	Prostatic Neoplasms	3p were downregulated in human PCa cells compared with normal prostate epithelial cells.
other	35686336	hsa-mir-483	Prostatic Neoplasms	3p were downregulated in human PCa cells compared with normal prostate epithelial cells.
epigenetics	35686306	hsa-mir-124-2	Uterine Cervical Dysplasia	CONCLUSIONS: Compared with HPV16/18 genotyping, the FAM19A4/miR124-2 methylation test detects nonproductive, transforming CIN2/3 lesions with high specificity in women aged <30 years, providing clinicians supportive information about the need for treatment of CIN2/3 in young HPV-positive women.
epigenetics	35686306	hsa-mir-124-2	Papillomavirus Infections	CONCLUSIONS: Compared with HPV16/18 genotyping, the FAM19A4/miR124-2 methylation test detects nonproductive, transforming CIN2/3 lesions with high specificity in women aged <30 years, providing clinicians supportive information about the need for treatment of CIN2/3 in young HPV-positive women.
other	35686126	hsa-mir-125a	Arthritis, Rheumatoid	Furthermore, circNUP214 functioned as a ceRNA for miR-125a-3p in RA patients.
other	35685465	hsa-mir-743a	Cardiotoxicity	In addition, the expression profile of miR-743a and Mob1b are consistent with skeletal muscle recovery after Cardiotoxin (CTX) injury.
circulation_biomarker_diagnosis_ns	35685351	hsa-mir-92a	Carcinoma, Non-Small-Cell Lung	CONCLUSION: By assessing the expression and functional profile of DEmiRs in the plasma exosomes of NSCLC patients after radiotherapy, miR-92a-3p was identified as a promising target affecting radiotherapy outcomes through the Ras signaling pathway.
other	35683791	hsa-mir-200c	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-150	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-9	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-125a	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-34a	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-148b	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
other	35683791	hsa-mir-133a	Breast Neoplasms	3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT.
circulation_biomarker_diagnosis_up	35683018	hsa-mir-153	Prostatic Neoplasms	Being upregulated in high GS human PC, miR-153 could be proposed as a circulating biomarker for PC diagnosis.
other	35682971	hsa-mir-21	Colorectal Neoplasms	Our findings suggest that a combination of coffee compounds reduces early-stage colon carcinogenesis by the modulation of miR-21a-5p expression, highlighting the importance of coffee intake to prevent CRC.
lncRNA target	35682879	hsa-mir-224	Osteosarcoma	A mechanistic study showed that circSRSF4 can be used as an miR-224 sponge to up-regulate the expression of Rac1, thereby promoting the development of osteosarcoma. (4) Conclusions: CircSRSF4 acting as a ceRNA promotes the malignant behavior of osteosarcoma through the circSRSF4/miR-224/Rac1 axis, which provides a new theoretical basis for the clinical prevention and treatment of osteosarcoma and the study of related markers and intervention targets.
other	35682732	hsa-mir-205	Cervical Intraepithelial Neoplasia	The expression of miR5p was lower in both CIN and cancer samples compared to normal samples.
other	35682732	hsa-mir-205	Uterine Cervical Neoplasms	The expression of miR5p was lower in both CIN and cancer samples compared to normal samples.
other	35682716	hsa-mir-378f	Stomach Neoplasms	Hsa-miR-378f was identified as showing a statistically significant correlation in GC patients receiving XELOX chemotherapy according to the analysis of differentially expressed (DE) miRNAs.
lncRNA target	35682670	hsa-mir-10b	Glioblastoma	aryl-1H-imidazole scaffold, used in combination with a miRNA inhibitor molecule targeting the oncomiRNA miR-10b-5p.
other	35682668	hsa-mir-143	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-100	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-22	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-495	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-18a	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-576	Obesity	3p (rs = -0.308).
other	35682668	hsa-mir-18b	Obesity	3p (rs = -0.308).
other	35682646	hsa-mir-21	Cardiotoxicity	Additionally, cardiac mirR-21 and miR-26a were assessed.
other	35682646	hsa-mir-26a	Cardiotoxicity	Additionally, cardiac mirR-21 and miR-26a were assessed.
lncRNA target	35682592	hsa-mir-126	Alzheimer Disease	However, 158 microRNAs were significantly dysregulated in AD NMV compared to controls, some of which were associated with BBB dysfunction, including miR-210, miR-20b-5p and miR5p.
lncRNA target	35682592	hsa-mir-210	Alzheimer Disease	However, 158 microRNAs were significantly dysregulated in AD NMV compared to controls, some of which were associated with BBB dysfunction, including miR-210, miR-20b-5p and miR5p.
lncRNA target	35682548	hsa-mir-375	Neuroblastoma	These results indicate that IH stress increases levels of DBH and PNMT via the inhibition of miRmediated mRNA degradation, potentially playing a role in the emergence of hypertension in SAS patients.
circulation_biomarker_diagnosis_up	35682544	hsa-mir-451a	Endometriosis	BACKGROUND: miR-451a can function as a tumor suppresser and has been shown to be elevated in both endometriotic lesion tissue and serum from women with endometriosis.
lncRNA target	35682544	hsa-mir-25	Endometriosis	3p and PTEN, while in vitro cell transfection studies suggest that miR-451a may regulate PTEN expression via modulating miR
lncRNA target	35681793	hsa-mir-378a	Prostatic Neoplasms	Herein, we first demonstrated how miR-378 exerts anti-prostate cancer (PCa) actions by influencing multiple target genes, including KLK2, KLK4, KLK6, and KLK14, which are implicated in PCa development, cell proliferation, and cell survival. The results showed high significance after EPA induced tumor cells containing higher expression levels of miR-378, and led the PCa cells having low cell viabilities, and they progressed to apoptosis when compared with normal prostate cells (p < 0.001).
lncRNA target	35681793	hsa-mir-378	Prostatic Neoplasms	Herein, we first demonstrated how miR-378 exerts anti-prostate cancer (PCa) actions by influencing multiple target genes, including KLK2, KLK4, KLK6, and KLK14, which are implicated in PCa development, cell proliferation, and cell survival. The results showed high significance after EPA induced tumor cells containing higher expression levels of miR-378, and led the PCa cells having low cell viabilities, and they progressed to apoptosis when compared with normal prostate cells (p < 0.001).
other	35681658	hsa-mir-152	Thyroid Cancer, Papillary	5p (FDR < 0.05; |fold change (FC)| >/= 1.5).
other	35681658	hsa-mir-551b	Thyroid Cancer, Papillary	5p (FDR < 0.05; |fold change (FC)| >/= 1.5).
other	35681658	hsa-mir-7	Thyroid Cancer, Papillary	5p (FDR < 0.05; |fold change (FC)| >/= 1.5).
other	35681658	hsa-mir-146b	Thyroid Cancer, Papillary	5p (FDR < 0.05; |fold change (FC)| >/= 1.5).
other	35681658	hsa-mir-221	Thyroid Cancer, Papillary	5p (FDR < 0.05; |fold change (FC)| >/= 1.5).
lncRNA target	35681518	hsa-let-7e	Myocardial Infarction	Additionally, given its involvement in modulating endothelial cell function and vascularization, altered let-7e-5p expression may constitute a therapeutic biomarker and target for ischemic heart disease.
other	35680981	hsa-mir-1273f	Osteoporosis	Besides, the two axes of hsa_circR_0028877/hsa-miR-1273f/CAMK2A and hsa_circR_0028877/hsa-miR-1273f/DIRAS2 conformed to be closely associated with OP.
circulation_biomarker_diagnosis_up	35680806	hsa-mir-34a	Thrombocytopenia	RESULTS: Among the 69 DLBCL patients, 36 patients developed thrombocytopenia after 2 cycles of R-CHOP 21 regimen for chemotherapy, the incidence was 52.17%; the level of serum IL-11 and the relative expression of miR-34a mRNA in the reduction group were significantly lower than the non reduction group (P<0.05), compared other data between groups, there was no statistical significant difference (P>0.05); after Logistic regression analysis, the results showed that the level of serum IL-11 and the relative expression of miR-34a mRNA were related to thrombocytopenia after chemotherapy in DLBCL patients, low expression of each index may be a risk factor of thrombocytopenia after chemotherapy in DLBCL patients (OR>1, P<0.05); ROC curve was drawn, and the results showed that the AUC of serum IL-11 level and miR-34a mRNA relative expression before chemotherapy alone and in combination predicted the risk of thrombocytopenia after chemotherapy in DLBCL patients were all >0.80, and the predictive value was ideal, when the cut-off value of serum IL-11 level before chemotherapy was 42.094 pg/ml, and the cut-off value of miR-34a mRNA relative expression was 3.894, the combined prediction value was the best.
circulation_biomarker_diagnosis_up	35680806	hsa-mir-34a	Lymphoma, Large B-Cell, Diffuse	RESULTS: Among the 69 DLBCL patients, 36 patients developed thrombocytopenia after 2 cycles of R-CHOP 21 regimen for chemotherapy, the incidence was 52.17%; the level of serum IL-11 and the relative expression of miR-34a mRNA in the reduction group were significantly lower than the non reduction group (P<0.05), compared other data between groups, there was no statistical significant difference (P>0.05); after Logistic regression analysis, the results showed that the level of serum IL-11 and the relative expression of miR-34a mRNA were related to thrombocytopenia after chemotherapy in DLBCL patients, low expression of each index may be a risk factor of thrombocytopenia after chemotherapy in DLBCL patients (OR>1, P<0.05); ROC curve was drawn, and the results showed that the AUC of serum IL-11 level and miR-34a mRNA relative expression before chemotherapy alone and in combination predicted the risk of thrombocytopenia after chemotherapy in DLBCL patients were all >0.80, and the predictive value was ideal, when the cut-off value of serum IL-11 level before chemotherapy was 42.094 pg/ml, and the cut-off value of miR-34a mRNA relative expression was 3.894, the combined prediction value was the best.
genetics_knock down_suppress	35680727	hsa-mir-1253	Nasopharyngeal Carcinoma	RESULTS: CircFIP1L1 overexpression and miR-1253 knockdown repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity.
genetics_overexpression_promote	35680520	hsa-mir-122	Pediatric Obesity	Overexpression of miR
genetics_knock down_promote	35680373	hsa-mir-22	Meningioma	In vitro studies showed that IMAT1 promoted meningioma cell invasion through the inactivation of the Kruppel-like factor 4 (KLF4)/hsa-miR22-3p/Snai1 pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor suppressive properties of KLF4 by preserving its tumor suppressor pathway.
genetics_knock down_promote	35680372	hsa-mir-558	ankylosing spondylitis 1	In summary, our key findings demonstrated that knockdown of MALAT1 served as a potential suppressor of AS by upregulating miR-558 via the downregulation of GSDMD expression.
circRNA target	35679712	hsa-mir-291a	Acute Lung Injury	Therefore, our results suggested that circNCLN/miR-291a-3p/TSLP axis may be an important signaling in LPS-induced ALI and circNCLN inhibition may serve as a potential treatment of ALI.
other	35679261	hsa-mir-146a	Respiratory Distress Syndrome	However, the role of miR-146a-5p and TLR7 signaling in pulmonary inflammation, endothelial activation, and sepsis-associated acute respiratory distress syndrome remains unclear. Together, these data demonstrate that TLR7 activation elicits pulmonary inflammation and endothelial barrier disruption by sensing extracellular miR-146a-5p and contributes to sepsis-associated acute respiratory distress syndrome.
other	35679261	hsa-mir-146a	Sepsis	However, the role of miR-146a-5p and TLR7 signaling in pulmonary inflammation, endothelial activation, and sepsis-associated acute respiratory distress syndrome remains unclear. Together, these data demonstrate that TLR7 activation elicits pulmonary inflammation and endothelial barrier disruption by sensing extracellular miR-146a-5p and contributes to sepsis-associated acute respiratory distress syndrome.
genetics_knock down_suppress	35678981	hsa-mir-98	Inflammation	CONCLUSIONS: SNHG14 knockdown alleviated OGD/induced N2A cell apoptosis, ER stress, inflammation and oxidative stress by depleting BCL2L13 via increasing miR
transcription factor target	35678979	hsa-mir-138	Epilepsy	ZNF883 inhibits NLRP3 ubiquitination and promotes EP through upregulating USP47 by sponging miR
lncRNA target	35678943	hsa-mir-127	Breast Neoplasms	CONCLUSION: In summary, our results reported the regulatory mechanism of FOXD3-AS1 in breast cancer progression by targeting miR3p/ARF6 axis to affect cell proliferation, migration, invasion and tumor growth.
genetics_knock down_promote	35678942	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	3p upregulation on NSCLC cell proliferation, invasion and migration were reversed by BRD9 overexpression.
genetics_knock down_suppress	35678923	hsa-mir-424	Diabetic Nephropathies	CONCLUSION: Circ_0000064 knockdown ameliorated HG-induced HRMC dysfunctions through miR5p enrichment-mediated WNT2B inhibition, hinting that circ_0000064 contributed to DN development.
transcription factor target	35678909	hsa-mir-1224	Glioblastoma	5p could be a potential target for the prognosis and treatment in GBM.
lncRNA target	35678907	hsa-mir-206	Memory Disorders	CONCLUSION: The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR
lncRNA target	35678907	hsa-mir-1	Memory Disorders	CONCLUSION: The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR
circulation_biomarker_diagnosis_ns	35678691	hsa-mir-155	Lung Neoplasms	Using ANX-bead capturing and reverse transcription and quantitative PCR, we detected significantly higher levels of CK19 mRNA, MALAT1 lncRNA, and miR155 miRNA in the plasma of lung cancer patients.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-20a	Post-Concussion Syndrome	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-127	Platelet Storage Pool Deficiency	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-20a	Platelet Storage Pool Deficiency	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-20a	Papillon-Lefevre Disease	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-127	Papillon-Lefevre Disease	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. In order to validate the miRNAs 127 and 320a methodologically, as PSL biomarkers in a large number of PC bags, we also evaluated important immunological markers involved in the platelet activation/aggregation process-the CD62P receptor (P-selectin), the surface glycoproteins (GP) IIb/IIIa, and the purinergic P2Y12 receptor-via flow cytometry.
circulation_biomarker_diagnosis_up	35678655	hsa-mir-127	Post-Concussion Syndrome	Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs.
target gene	35677888	hsa-mir-182	Thyroid Neoplasms	CircSND1/miR-182-5p Axis Promotes Proliferative and Invasive Abilities of Thyroid Cancer via Binding Targeting MET.
other	35677715	hsa-mir-465	Infertility	Despite abundant expression in the testis, ablation of the miR-465 miRNA cluster using CRISPR-Cas9 did not cause infertility.
other	35677668	hsa-mir-24	Ovarian Neoplasms	Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression.
exosome	35677105	hsa-mir-23a	Thyroid Cancer, Papillary	Inhibitor-miR-23a-3p protected h9c2 cells from ferroptosis accompanying with upregulation of SLC7A11. In conclusion, our results suggest that CF-exos-miR-23a-3p may promote ferroptosis.
exosome	35677105	hsa-mir-23a	Atrial Fibrillation	Inhibitor-miR-23a-3p protected h9c2 cells from ferroptosis accompanying with upregulation of SLC7A11. In conclusion, our results suggest that CF-exos-miR-23a-3p may promote ferroptosis.
other	35676651	hsa-mir-10a	Glioma	RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE.
other	35676651	hsa-mir-10b	Glioma	RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE.
other	35676651	hsa-mir-629	Glioma	RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE.
exosome	35676597	hsa-mir-130b	Diabetes, Gestational	CONCLUSION: Conclusively, GDM-MSCs-derived exosomes shuttling miR-130b-3p repressed proliferation, migration, and angiogenesis of HUVECs by regulating ICAM-1 expression.
other	35676585	hsa-mir-199a	Cardiovascular Diseases	The two miRNAs with the highest interaction and expression in the development of CVDs were hsa-miR-199a-5p and hsa-miR-199a-3p.
genetics_overexpression_promote	35676548	hsa-mir-630	Carcinoma, Ovarian Epithelial	CircCERS6 overexpression hampered the proliferation, migration, invasion, and EMT of EOC cells by up-regulating RASSF8 via sponging miR-630.
lncRNA target	35675666	hsa-mir-1226	Nasopharyngeal Carcinoma	Conclusion: These findings indicate that downregulation of GUSBP11 alleviates NPC development by regulating the miR
exosome	35674868	hsa-mir-128	Stomach Neoplasms	Conclusively, LINC01091 shuttled by tumor-derived Exos might expedite GC development by activating the ELF4/CDX2 axis via miR
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-21	Hyperlipidemias	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-126	Hyperlipidemias	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
other	35674773	hsa-mir-29a	Hyperlipidemias	miR-29a might serve as a potential early diagnostic biomarker of endothelial injury-related diseases.
circulation_biomarker_diagnosis_ns	35674773	hsa-let-7a	Hyperlipidemias	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
other	35674773	hsa-mir-29a	Myocardial Infarction, Acute	miR-29a might serve as a potential early diagnostic biomarker of endothelial injury-related diseases.
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-26a	Myocardial Infarction, Acute	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
circulation_biomarker_diagnosis_ns	35674773	hsa-let-7a	Myocardial Infarction, Acute	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-26a	Hyperlipidemias	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-126	Myocardial Infarction, Acute	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
circulation_biomarker_diagnosis_ns	35674773	hsa-mir-21	Myocardial Infarction, Acute	The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased.
genetics_overexpression_promote	35674441	hsa-mir-675	Nasopharyngeal Carcinoma	5p and results in p53 protein overexpression in EBVaGC and NPC cells.
genetics_overexpression_promote	35674441	hsa-mir-675	Epstein-Barr Virus Infections	5p and results in p53 protein overexpression in EBVaGC and NPC cells.
genetics_overexpression_promote	35674441	hsa-mir-675	Corneal dystrophy, epithelial basement membrane	5p and results in p53 protein overexpression in EBVaGC and NPC cells.
other	35674190	hsa-mir-1205	Colorectal Neoplasms	Reverse transcriptionquantitative PCR analysis was performed to detect circ_0006174, miR1205 and calciumbinding epidermal growth factor domaincontaining protein 1 (CCBE1) expression levels in CRC tissues and cell lines. Circ_0006174 is an oncogenic circRNA, which participates in the promotion of CRC progression by regulating the miR1205/CCBE1/Wnt pathway.
lncRNA target	35674159	hsa-mir-28	Reperfusion Injury, Renal Ischemia	On the whole, the findings of the present study revealed a regulatory pathway modulating miR3283p in IRI, demonstrating that the GATA1mediated regulation of circITGB1 enhanced the H/Rinduced inflammatory response via the miR3283p/PIM1 axis.
genetics_knock down_suppress	35674016	hsa-mir-455	Inflammation	SOX2-OT knockdown or miR
lncRNA target	35673973	hsa-mir-144	Hepatorenal Syndrome	This study investigated the potential beneficial effects of resveratrol on diclofenac-induced hepatorenal toxicity and explored the role of miR-144 and its relationship to oxidative stress and inflammation triggered by diclofenac. In conclusion, this study demonstrates a potential therapeutic role of resveratrol in mitigating diclofenac-induced hepatorenal insult, possibly via modulating miR-144/Nrf2/GSH axis.
genetics_overexpression_promote	35673915	hsa-mir-744	Carcinoma, Renal Cell	5p overexpression on ccRCC cell proliferation, migration, and invasion (all P < 0.05).
other	35673634	hsa-mir-339	Prostatic Neoplasms	5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis.
other	35673634	hsa-mir-125a	Prostatic Neoplasms	5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis.
other	35673634	hsa-mir-30	Prostatic Neoplasms	5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis.
other	35673634	hsa-mir-613	Prostatic Neoplasms	5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis.
circulation_biomarker_diagnosis_ns	35673562	hsa-mir-144	limb ischemia	Conclusion: The results expand the scope of blood-borne substances involved in vascular homeostasis and suggest that anti-miR
other	35673452	hsa-mir-126	Diabetes Mellitus	The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes.
other	35673452	hsa-mir-222	Diabetes Mellitus	The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes.
other	35673452	hsa-mir-29a	Diabetes Mellitus	The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes.
genetics_knock down_promote	35672774	hsa-mir-18a	Ovarian Neoplasms	miR-18a-5p knockdown and NACC1 overexpression both annulled the inhibition of hMSC-EVs on OC cell growth.
other	35672444	hsa-mir-19a	Colonic Neoplasms	Then, sequencing platelet miRNome, we identify miR-19a as the highest expressed miRNA in obese subjects and prove that miR-19a is induced in colon cancer. Last, administration of miR-19a per se in the xenograft colon cancer model is able to promote colon cancer growth.
other	35672444	hsa-mir-19a	Obesity, Abdominal	Then, sequencing platelet miRNome, we identify miR-19a as the highest expressed miRNA in obese subjects and prove that miR-19a is induced in colon cancer. Last, administration of miR-19a per se in the xenograft colon cancer model is able to promote colon cancer growth.
other	35672285	hsa-mir-181d	Fibrosis, Renal	In vivo, treatment with miR-181d-containing BMSC-derived EVs was able to restrict the progression of fibrosis in UUO-induced rats.
genetics_GWAS	35672274	hsa-mir-149	Carcinoma, Hepatocellular	CONCLUSION: miR-149 rs2292832 polymorphism might be a novel prognostic biomarker for HCC patients with bone metastasis.
genetics_overexpression_promote	35670956	hsa-mir-203a	Carcinoma, Non-Small-Cell Lung	Overexpression of miR-203a-3p inhibits NSCLC cell proliferation, migration and invasion, and promotes cellular apoptosis in vitro.
genetics_knock down_promote	35670955	hsa-mir-433	Amyloidosis	In conclusion, circ-HUWE1 knockdown alleviates Amyloid-beta-induced neuronal injury in SK-N-SH cells via miR
genetics_knock down_promote	35670955	hsa-mir-433	Plaque, Amyloid	In conclusion, circ-HUWE1 knockdown alleviates Amyloid-beta-induced neuronal injury in SK-N-SH cells via miR
lncRNA target	35670535	hsa-mir-9a	Inflammatory Bowel Diseases	This study found that miRNA-9a-5p could inhibit the TLR4 signaling activation by targeting FOXO1, thereby exerting a protective effect on the mucosal barrier injury in IBD.
genetics_overexpression_promote	35670491	hsa-mir-28	Cholangiocarcinoma	5p-overexpression CCA cells and their control cells, which further confirmed that CD44 was required in miR
circulation_biomarker_diagnosis_ns	35670145	hsa-mir-1	Myocardial Infarction	Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown.
circulation_biomarker_diagnosis_ns	35670145	hsa-mir-208b	Myocardial Infarction	Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown.
circulation_biomarker_diagnosis_ns	35670145	hsa-mir-499	Myocardial Infarction	Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown.
lncRNA target	35669642	hsa-mir-223	Stomach Neoplasms	Our results showed that Celecoxib could reverse invasion and metastasis of gastric cancer through Lnc_AC006548.28-miRLAMC2 pathway.
other	35669607	hsa-mir-155	Chronic Periodontitis	RESULTS: The level of miR-155 was significantly higher in patients with chronic periodontitis (P < 0.001). CONCLUSION: As the expression level of miR-155, TNF-alpha, and IL-6 genes was higher in subjects with chronic periodontitis than healthy individuals, it might suggest a role for miR-155 in patients with chronic periodontitis.
exosome	35669425	hsa-mir-411	Colonic Diseases	Upon entering OL cells, exosomal miR
genetics_overexpression_promote	35669376	hsa-mir-339	Colonic Neoplasms	COL11A1 upregulation promoted colon carcinoma cell functions, while overexpressing miR
target gene	35669244	hsa-mir-205	Stomach Neoplasms	MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.
genetics_knock down_promote	35669195	hsa-mir-363	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-340	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-29b	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-6807	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-142	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-451a	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-144	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669195	hsa-mir-486	Moyamoya Disease	Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA
genetics_knock down_promote	35669102	hsa-mir-28	gastric adenocarcinoma	3p overexpression.
lncRNA target	35669101	hsa-mir-138	Carcinoma, Hepatocellular	5p may serve as a useful therapeutic target for miRNA-based HCC therapy.
other	35668995	hsa-mir-130b	Polycystic Ovary Syndrome	Forced expression of ZNF217 in PCOS theca cells reduced androgen production, CYP17A1 and DENND1A.V2 mRNA, while increasing mIR-130b-3p. These observations suggest that ZNF217 is part of a network of PCOS candidate genes regulating thecal cell androgen production involving DENND1A.V2 and miR-130b-3p.
other	35668916	hsa-mir-455	Carotid Stenosis	5p is an independent risk factor for the degree of CAS, and has a certain predictive value for the development of CIEs.
exosome	35668915	hsa-mir-142	Rhinitis, Allergic	CONCLUSION: Tfh-derived exosomes induce DC maturation by regulating miR5p/CDK5/STAT3 signaling pathway, thereby promoting the occurrence of AR.
other	35668777	hsa-mir-590	Myocardial Reperfusion Injury	5p and the heart development transcription factor KBTBD7.
lncRNA target	35668775	hsa-mir-410	Arthritis, Rheumatoid	Our data suggest that TSC can inhibit the excessive proliferation of FLS to treat RA, the mechanism of which may be closely related to regulation of the lncRNA OIP5-AS1/miR
circRNA target	35668527	hsa-mir-494	Small Cell Lung Carcinoma	CONCLUSIONS: CircVAPA promotes SCLC progression via the miR
circRNA target	35668527	hsa-mir-377	Small Cell Lung Carcinoma	CONCLUSIONS: CircVAPA promotes SCLC progression via the miR
other	35668388	hsa-mir-19b	Metabolic Diseases	Seminal miR19b levels were also negatively correlated with metabolic syndrome.
other	35668388	hsa-mir-19a	Metabolic Diseases	Seminal miR19b levels were also negatively correlated with metabolic syndrome.
other	35668364	hsa-mir-218-1	Abortion, Spontaneous	CONCLUSIONS: TCS regulated miR1-3p/SLC35C1 axis to modulate the proliferation, migration, invasion and inflammatory response of trophoblast cells in vitro, which might provide novel insights for spontaneous abortion prevention.
other	35668364	hsa-mir-218	Abortion, Spontaneous	CONCLUSIONS: TCS regulated miR1-3p/SLC35C1 axis to modulate the proliferation, migration, invasion and inflammatory response of trophoblast cells in vitro, which might provide novel insights for spontaneous abortion prevention.
other	35668332	hsa-mir-137	Breast Neoplasms	While miR-124a levels increased (p = 0.021) in the tumor tissue, the expression of miR-137 was downregulated (p = 0.041) after NACT in HR positive BC. Although miRs levels did not impact the response to NACT, we found miR-124a and miR-137 levels to be related to hormonal sensitivity of BC.
other	35668131	hsa-mir-221	Pulmonary Arterial Hypertension	5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction.
other	35668131	hsa-mir-218	Pulmonary Arterial Hypertension	5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction.
other	35668131	hsa-mir-873	Pulmonary Arterial Hypertension	5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction.
transcription factor target	35667855	hsa-mir-199a	Lung Injury	In summary, the BMSC-exo could participate in the regulation of ENaC through miR-199a-3p originated from BMSC-exo, thereby providing a new pharmacological tool for the treatment of ALI.
lncRNA target	35667653	hsa-mir-20b	Breast Neoplasms	Conclusion: Overall, this study highlights the important role of LINC00680 in docetaxel resistance through the miR-320b/CDKL5 pathway and provides a novel therapeutic strategy for BC drug resistance.
genetics_overexpression_promote	35667541	hsa-mir-424	Acute Lung Injury	Overexpression of miR
other	35667514	hsa-mir-432	Carcinoma, Non-Small-Cell Lung	Mechanistically, circASCC3 sponged miR5p to increase complement C5a levels, which enhanced the progression and dysfunctional immune status of NSCLC.
other	35667342	hsa-mir-410	Abortion, Habitual	5p and lower ITGA6 expression.
transcription factor target	35667086	hsa-mir-132	Colorectal Neoplasms	3p inhibits the proliferation, migration and invasion of CRC cells.
lncRNA target	35666685	hsa-mir-140	Leukemia, Myeloid, Acute	CONCLUSION: MiR-140 may target FAM230B to suppress cell proliferation in AML.
transcription factor target	35666636	hsa-mir-548d	Stomach Neoplasms	Dual-fluorescence and quantitative PCR assays clarified that miR-548d-3p may be one of the target miRNAs of GKN1, which was up-regulated in GC tissues. CONCLUSIONS: In summary, we clarified that miR-548d-3p regulates GKN1 to participate in GC cell migration and invasion, and provides a possible target for the prognostic diagnosis and treatment of GC.
circulation_biomarker_diagnosis_up	35666610	hsa-mir-22	Carcinoma, Hepatocellular	METHODS: Real-time reverse transcription polymerase chain reaction (RT-PCR) was carried out to detect serum miR-16, miR-22, and miR-122 expression in 100 HCC patients and 100 controls (including hepatitis B, liver cirrhosis, liver metastases, hepatic hemangioma, health group, and each of them had 20 subjects).
circulation_biomarker_diagnosis_up	35666610	hsa-mir-122	Carcinoma, Hepatocellular	CONCLUSION: Our findings illustrate that both circulating miR-16 and miR-122 can provide value for early diagnosis of HCC and they are potential biomarkers for the early-stage HCC.
circulation_biomarker_diagnosis_up	35666610	hsa-mir-16	Carcinoma, Hepatocellular	CONCLUSION: Our findings illustrate that both circulating miR-16 and miR-122 can provide value for early diagnosis of HCC and they are potential biomarkers for the early-stage HCC.
epigenetics	35666529	hsa-mir-124-2	Cervical Intraepithelial Neoplasia	A negative FAM19A4/miR124-2 methylation test can rule out progressive CIN disease in pregnant women diagnosed with CIN3.
transcription factor target	35666424	hsa-mir-424	Breast Neoplasms	3p is more effective in inhibiting MCF-7 breast cancer development than monotherapies with miR
transcription factor target	35666424	hsa-mir-142	Breast Neoplasms	3p is more effective in inhibiting MCF-7 breast cancer development than monotherapies with miR
genetics_knock down_promote	35666423	hsa-mir-517b	Carcinoma, Hepatocellular	Meanwhile, miR-517b-3p has overexpression in PVTT samples, and serves as a candidate diagnostic and prognostic biomarker in HCC patients with PVTT.
exosome	35666058	hsa-mir-92b	Ventricular Premature Complexes	Real-Time quantitative PCR (RT-qPCR) experiments showed that miR-92b-3p, which is important for alleviating VC, was expressed highly in both VSMCs and exosomes after CUR intervention. In addition, in the rat calcification models, CUR attenuated vitamin D3-induced VC by increasing miR-92b-3p expression and decreasing KLF4 expression in the aorta.
circulation_biomarker_diagnosis_up	35664973	hsa-mir-27b	Alopecia Areata	Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls.
circulation_biomarker_diagnosis_up	35664973	hsa-mir-101	Alopecia Areata	Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls.
circulation_biomarker_diagnosis_up	35664973	hsa-mir-2355	Alopecia Areata	Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls.
circulation_biomarker_diagnosis_up	35664973	hsa-mir-103	Alopecia Areata	Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls.
epigenetics	35664920	hsa-mir-155	Pre-Eclampsia	This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Results showed that miR-155 was remarkably upregulated and inversely correlated with the promoter methylation level in the placental tissue from PE patients.
lncRNA target	35664787	hsa-mir-30	Urinary Bladder Neoplasms	5p inhibitor.
other	35664767	hsa-mir-181a	Lung Neoplasms	More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD.
other	35664767	hsa-mir-181a	Adenocarcinoma of Lung	More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD.
other	35664431	hsa-mir-29b	Neurogenic Inflammation	CONCLUSION: CGA upregulates MIR497HG to curb miR-29b-3p expression, hence initiating the SIRT1/NF-kappaB signaling pathway and repressing OGD-elicited inflammation, oxidative stress, and neuron apoptosis.
other	35664431	hsa-mir-497	Neurogenic Inflammation	CONCLUSION: CGA upregulates MIR497HG to curb miR-29b-3p expression, hence initiating the SIRT1/NF-kappaB signaling pathway and repressing OGD-elicited inflammation, oxidative stress, and neuron apoptosis.
other	35663991	hsa-mir-146a	psoriasis 1	In addition, estrogen was found to affect the expression of certain genes (vgll3 and cebpb), microRNAs (miR146a and miR21), and immune cells (DCs and gammadelta T cells) as well as chemokines (CCL5 and CXCL10) and cytokines (TNF-alpha, IL-6, IL-22, IL-23, and IL-17 family), which promoted the skin inflammation.
other	35663991	hsa-mir-21	psoriasis 1	In addition, estrogen was found to affect the expression of certain genes (vgll3 and cebpb), microRNAs (miR146a and miR21), and immune cells (DCs and gammadelta T cells) as well as chemokines (CCL5 and CXCL10) and cytokines (TNF-alpha, IL-6, IL-22, IL-23, and IL-17 family), which promoted the skin inflammation.
lncRNA target	35663842	hsa-mir-423	Stomach Neoplasms	CONCLUSION: CircPVT1 modulated cell growth, invasion and migration through EMT mediation in gastric cancer through miR5p/Smad3 pathway.
genetics_overexpression_suppress	35663593	hsa-mir-132	Retinoblastoma	3p inhibition or PAX6 overexpression reversed circRNF20 deficiency-mediated effects on RB cell malignant behaviors.
other	35663558	hsa-mir-10b	Amyotrophic Lateral Sclerosis	The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE ALS.
other	35663558	hsa-mir-10b	Brain Injury, Chronic	The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE ALS.
other	35663309	hsa-mir-1224	Myocardial Ischemia	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-147	Diabetes Mellitus, Type 2	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-615	Myocardial Ischemia	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-147	Myocardial Ischemia	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-615	Diabetes Mellitus, Type 2	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-5196	Diabetes Mellitus, Type 2	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-1224	Diabetes Mellitus, Type 2	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-5196	Myocardial Ischemia	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-548b	Myocardial Ischemia	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
other	35663309	hsa-mir-548b	Diabetes Mellitus, Type 2	3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD.
lncRNA target	35663229	hsa-mir-15a	Neuroblastoma	These findings demonstrate that miR-15a and miR-15b induce an anti-tumor immune response by targeting PD-L1 in NB.
lncRNA target	35663229	hsa-mir-15b	Neuroblastoma	These findings demonstrate that miR-15a and miR-15b induce an anti-tumor immune response by targeting PD-L1 in NB.
other	35663198	hsa-mir-432	Carcinoma, Hepatocellular	In this study, using bioinformatic analysis as well as cellular and animal models, we screened the differentially expressed (DE) miRNA-432 and SLC38A1 gene in ASH.
other	35663198	hsa-mir-432	Fatty Liver, Alcoholic	In this study, using bioinformatic analysis as well as cellular and animal models, we screened the differentially expressed (DE) miRNA-432 and SLC38A1 gene in ASH.
lncRNA target	35663194	hsa-mir-664a	Cardiovascular Diseases	And lncRNA Punisher and miR-664a-5p could serve as the novel and potential targets in the diagnosis and treatment of cardiovascular diseases.
genetics_GWAS	35662862	hsa-mir-21	Breast Neoplasms	Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell (CSC) population after 3 cycles of standard chemotherapy. The miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR (real-time PCR) using the standard protocol.
circRNA target	35662705	hsa-mir-132	Colorectal Neoplasms	Furthermore, we found quercetin can notably suppress the progression of CRC via mediation of the hsa_circ_0006990/miR3p/MUC13 axis.
genetics_overexpression_promote	35662671	hsa-mir-542	Tuberculosis	Overexpression of VPS11 or depletion of miR
transcription factor target	35662508	hsa-mir-143	Schizophrenia	Notably, miR143-3p is a critical NRG-1 target related to mitochondrial dysfunction, and miR143-3p levels in neural stem cells associate with severity to olanzapine resistance in TRS. CONCLUSIONS: Our findings provide direct evidence of olanzapine resistance resulting from NRG-1 deficiency-induced mitochondrial dysfunction, and they link olanzapine resistance and NRG-1 deficiency-induced mitochondrial dysfunction to an NRG-1/miR143-3p axis, which constitutes a novel biomarker and target for TRS.
transcription factor target	35662287	hsa-mir-200c	Non-alcoholic Fatty Liver Disease	Collectively, our results suggest that HAS2 is negatively regulated by miR-200c and contributes to the development of acute liver injury and chronic liver inflammation via hyaluronan-mediated immune signaling.
genetics_overexpression_promote	35662219	hsa-mir-181b	Brain Injuries, Traumatic	We found that miR181b overexpression effectively reduced apoptosis and neuroinflamatory response after traumatic brain injury and promoted the transformation of microglia to the anti-inflammatory phenotype.
circRNA target	35662113	hsa-mir-665	Angelman Syndrome	CONCLUSIONS: Circ_ARHGAP32 might be a potential target for AS treatment, which promoted ox-LDL-induced VSMCs proliferation and migration by regulating miR-665/FGF2 network.
other	35662106	hsa-mir-204	Breast Neoplasms	CONCLUSIONS: Our findings suggested that CREB5 could be a potential biomarker of disease progression in basal subtype of breast cancer, and that perturbations of the miR-204/CREB5 axis plays an important role in VM development in breast cancer cells.
lncRNA target	35662010	hsa-mir-19a	pancreatic adenocarcinoma	MiR-19a-3p was a downstream target of LINC01857, and miR-19a-3p levels were significantly decreased in PDAC cells. CONCLUSION: LINC01857 promotes malignant phenotypes of PDAC cells via upregulation of SMOC2 by interacting with miR-19a-3p.
circRNA target	35661832	hsa-mir-655	Stomach Neoplasms	Collectively, circXRCC5 facilitates GC progression through the HNRNPC/circXRCC5/miR
other	35661648	hsa-mir-148b	Glomerulonephritis, IGA	METHODS: We measured renal megalin mRNA and miR-148b, previously identified as a regulator of megalin, in a retrospective cohort of 417 IgAN patients at the time of biopsy, and evaluated their associations with chronic kidney disease (CKD) progression event, defined as end-stage renal disease or >/=40% decline in estimated glomerular filtration rate, using Cox proportional hazard models.
other	35661648	hsa-mir-148b	Renal Insufficiency, Chronic	METHODS: We measured renal megalin mRNA and miR-148b, previously identified as a regulator of megalin, in a retrospective cohort of 417 IgAN patients at the time of biopsy, and evaluated their associations with chronic kidney disease (CKD) progression event, defined as end-stage renal disease or >/=40% decline in estimated glomerular filtration rate, using Cox proportional hazard models.
lncRNA target	35661494	hsa-mir-451	Inferior Wall Myocardial Infarction	The results showed that IMI exposure induced autophagy accompanied by advanced autophagy markers BNIP3, Beclin1 and LC3/ in CIK cells, reduced the levels of miR-451, increased the expression of Cab39 and AMPK, inhibited AKT/mTOR signaling, and activated the JNK pathway. These results indicate that eucalyptol could alleviate IMI-induced autophagy through the miR-451/Cab39/AMPK axis in fish kidney cells.
other	35661455	hsa-let-7b	COVID-19	At the same time, MIRLET7BHG and MALAT1 are upregulated in excitatory neurons of FC and neurons of CP, respectively. Here, it is hypothesized that downregulation of NORAD, NEAT1, and STXBP5-AS1, and upregulation of MIRLET7BHG and MALAT1 might deregulate respectively 51, 6, and 37, and 31 and 19 mRNAs in cell types of FC and CP.
circRNA target	35661247	hsa-mir-135b	Adenocarcinoma of Lung	To summarize, we demonstrated that melatonin decreases the expression of circ_0017109 and suppresses the non-small-cell lung cancer cell migration, invasion, and proliferation through decreasing TOX3 expression via direct activation of miR-135b-3p.
lncRNA target	35660716	hsa-mir-1	Adenocarcinoma of Lung	3p/E2F8 constrained LUAD malignant progression through NF-kappaB pathway, which may provide possible targets for LUAD diagnosis and treatment.
exosome	35660458	hsa-mir-21	Breast Neoplasms	5p and miRNA-10b-5p, both of which are involved in EMT, in breast cancer-derived exosomes of various grades in order to identify new biomarkers involved in breast cancer progression.
exosome	35660458	hsa-mir-10b	Breast Neoplasms	5p and miRNA-10b-5p, both of which are involved in EMT, in breast cancer-derived exosomes of various grades in order to identify new biomarkers involved in breast cancer progression.
circulation_biomarker_diagnosis_up	35659970	hsa-mir-483	Carcinoma, Hepatocellular	5p or plasma hsa-miR
lncRNA target	35659969	hsa-mir-134	Depression	5p exerts an enormous effect on dendritic deficits by promoting AMPK-mediated mitophagy and provides a potential new target for antidepressant drug research and development.
circulation_biomarker_diagnosis_up	35659599	hsa-mir-27a	Alzheimer Disease	CONCLUSIONS: The expression trends of NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of AD patients are consistent, the level of NEAT1 is increased, and the level of miR-27a-3p is decreased.
other	35659483	hsa-mir-34a	Upper Tract Urothelial Carcinoma	Other non-coding RNAs, i.e.,: miR-34a, DLGAP1-AS1, USP39, and RNA5SP479, were highlighted by network analyses to have potential in the pathogenesis of UTUC.
other	35659238	hsa-mir-450a-2	Depressive Disorder, Major	3p and emotional abuse could effectively diagnose MDD in adolescents with 82.4% sensitivity and 81.6% specificity.
lncRNA target	35659199	hsa-mir-199b	Pancreatic Carcinoma	It was also discovered that myelin regulatory factor (MYRF) was targeted by miR-199b-5p and positively correlated with LINC01133 expression in PC, and LINC01133 modulated PC progression through miR-199b-5p/MYRF pathway. In conclusion, we demonstrated that YY1-mediated the upregulation of LINC0113 increased MYRF expression by sponging miR-199b-5p, resulting in the accelerated development of PC.
genetics_knock down_promote	35659193	hsa-mir-129	Periodontitis	Knockdown lncZFY's improvement effect on periodontitis was reversed by depressive miR
lncRNA target	35659191	hsa-mir-125a	Venous Thrombosis	All in all, suppression of LINC01123 restrains LEDVT via miR-125a-3p to target IL1R1.
lncRNA target	35658886	hsa-mir-296	Breast Neoplasms	CONCLUSION: Our results indicate that lncRNA ORLNC1 acts as a tumor suppressor by regulating the miR-296/PTEN axis in HER2+ breast cancer.
transcription factor target	35658330	hsa-mir-181b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The miRNA-181b-5p/SSX2IP axis may be a promising target for intervention against the malignant behaviors of ALL.
lncRNA target	35658236	hsa-mir-1298	Myocardial Reperfusion Injury	CONCLUSION: TNA has demonstrated a potential ability to alleviate the cardiac injury and attenuate the inflammatory response following ischemia-reperfusion in the rat model through modulation of the expression of RNA panel (VAV3 mRNA/miR-1298/lncRNA JRKL-AS1) and TNF- alpha protein.
lncRNA target	35658112	hsa-mir-210	Adenocarcinoma of Lung	3p could be a promising target for immunomodulatory therapeutic strategies against lung adenocarcinoma.
other	35657974	hsa-mir-222	Colonic Neoplasms	These findings identify a novel mechanism whereby post-M3R PKC/p38 MAPK signaling stimulates miR-222 expression and colon cancer cell proliferation.
circulation_biomarker_diagnosis_ns	35657638	hsa-mir-19a	Breast Neoplasms	Compared with normal subjects, miR-19a-3p was highly expressed in plasma of patients with breast cancer.
exosome	35657460	hsa-mir-16	Spinal Cord Injuries	CONCLUSIONS: Exosomal circZFHX3 inhibited LPS-induced BV-2 cell injury partly by regulating the miR
circulation_biomarker_diagnosis_ns	35657082	hsa-mir-375	Insulin Resistance	RESULTS: Circulating miR3p was related to fasting insulin and insulin resistance in participants with prediabetes.
circulation_biomarker_diagnosis_ns	35657082	hsa-mir-375	Prediabetic State	RESULTS: Circulating miR3p was related to fasting insulin and insulin resistance in participants with prediabetes.
lncRNA target	35656441	hsa-mir-452	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: MAGI2-AS3 inhibits ALL development via modulating miR
circRNA target	35656024	hsa-mir-668	Colorectal Neoplasms	3p/ID4 axis in CRC progression and provided potential therapeutic targets and clinical prognostic markers for CRC.
circulation_biomarker_diagnosis_ns	35655924	hsa-mir-196a	Abortion, Habitual	RESULTS: We first demonstrated that miR-196a-5p expression was higher in the cytotrophoblasts of villous tissues and plasma EVs from RM patients.
exosome	35655918	hsa-mir-887	Breast Neoplasms	3p in MDA-MB-231 cells, BC cells were treated with EV-inhi to observe drug resistance.
other	35655761	hsa-mir-4728	Breast Neoplasms	We showed here that mir-4728 was the most significantly upregulated pre-miRNA in HER2-positive breast cancer patients (fold-change: 4.37), and it could serve as a strong diagnostic factor for the HER2 status in breast cancer patients (p < 0.0001).
circulation_biomarker_diagnosis_ns	35655754	hsa-mir-153	Parkinson Disease	The plasma miR-153 level in de novo PD was lower than that in treated patients (p = 0.006), its level increased gradually with disease duration (r = 0.358, p = 0.002) and Unified Parkinson's Disease Rating Scale Part III score (r = 0.264, p = 0.022).
circulation_biomarker_diagnosis_ns	35655754	hsa-mir-223	Parkinson Disease	RESULTS: The expression levels of plasma miR-153 and miR-223 were significantly decreased in patients with PD relative to NCs.
other	35655727	hsa-mir-141	Urinary Bladder Neoplasms	In addition, the above two indicators are closely related to and related to the tumor grade of bladder cancer patients, and the high expression of miR-141 and CD147 brings the poor prognosis effect to bladder cancer patients.
genetics_knock down_suppress	35655441	hsa-mir-590	Esophageal Squamous Cell Carcinoma	Importantly, it was confirmed that LRP6 was miR-590's downstream target and LRP6 over-expression also partly abolished the role of miR-590 overexpression in ESCC cells.
genetics_overexpression_promote	35655310	hsa-mir-183	Breast Neoplasms	Phenotypic effects of miR-183 overexpression in triple-negative breast cancer (TNBC) cell lines were investigated in vitro and in vivo by quantifying migration, proliferation, tumor growth and metastasis.
genetics_overexpression_promote	35655310	hsa-mir-183	Triple Negative Breast Neoplasms	Phenotypic effects of miR-183 overexpression in triple-negative breast cancer (TNBC) cell lines were investigated in vitro and in vivo by quantifying migration, proliferation, tumor growth and metastasis. However, TNBC cell lines displayed reduced proliferation and invasion upon overexpression of pre-miR-183.
circRNA target	35655258	hsa-mir-1248	Prostatic Neoplasms	CONCLUSIONS: These results demonstrated that circ_0004585 played an oncogenic role during PCa invasion and metastasis by targeting the miR-1248/TM9SF4 axis while providing new insight into therapeutic strategy development for metastatic PCa.
circulation_biomarker_diagnosis_up	35655254	hsa-mir-382	Carcinoma, Hepatocellular	Upregulation of PTEN expression by plasmid transfection can reverse the invasive effect of miR
lncRNA target	35654787	hsa-mir-140	Prostatic Neoplasms	Collectively, our findings demonstrate that circSCAF8 contributes to PCa progression through the circSCAF8-miR
lncRNA target	35654787	hsa-mir-335	Prostatic Neoplasms	Collectively, our findings demonstrate that circSCAF8 contributes to PCa progression through the circSCAF8-miR
other	35654454	hsa-mir-183	Lung Neoplasms	We have previously reported that in different cancer types, including nonsmall cell lung cancer (NSCLC), the microRNA-183/96/182 cluster (m96cl) is highly repressed in cells that have undergone EMT.
other	35654124	hsa-mir-211	Parkinson Disease	Conclusively, these results emphasize the neurotherapeutic impact of empagliflozin in PD by moderating the GRP78/PERK/eIF2alpha/CHOP ER stress pathway, downregulating miR5p, resolving oxidative stress, lessening astrocyte/microglial activation and neuroinflammation, along with augmenting autophagy.
lncRNA target	35653827	hsa-mir-612	Breast Neoplasms	Besides, FKBP4 could activate the cell proliferation and inhibit cell apoptosis and autophagy, which could relieve the inhibitory effect of miR-3612 on breast cancer cells.
genetics_knock down_suppress	35653494	hsa-mir-185	Alveolar Bone Loss	CONCLUSION: As a target gene of miR5p, MZB1 plays a crucial role in inhibiting the migration of hPDLCs through NF-kappaB signaling pathway and deteriorating alveolar bone loss.
circulation_biomarker_diagnosis_ns	35653294	hsa-mir-1260b	Pediatric Obesity	We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR
circulation_biomarker_diagnosis_ns	35653294	hsa-mir-194	Pediatric Obesity	We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR
circulation_biomarker_diagnosis_ns	35653294	hsa-mir-130a	Pediatric Obesity	We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR
circulation_biomarker_diagnosis_ns	35653294	hsa-mir-516	Pediatric Obesity	We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR
circulation_biomarker_diagnosis_ns	35653294	hsa-mir-4709	Pediatric Obesity	We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR
other	35652400	hsa-mir-128	Prostatic Neoplasms	The study's question is: can miR-128/193a- 5p/494 be related to imatinib resistance in PCa? METHODS: LNCaP and PC3 cells were treated with imatinib in IC50 doses.
circulation_biomarker_diagnosis_ns	35652182	hsa-mir-582	Glioblastoma	CONCLUSION: High serum levels of miRNA
circulation_biomarker_diagnosis_ns	35652182	hsa-mir-363	Glioblastoma	CONCLUSION: High serum levels of miRNA
genetics_overexpression_promote	35652063	hsa-mir-613	Colorectal Neoplasms	RESULTS: CircEA-2a was overexpressed in CRC, while miR
target gene	35652045	hsa-mir-191	Colonic Neoplasms	Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p.
genetics_GWAS	35651980	hsa-mir-222	Thyroid Cancer, Papillary	3p in PTC tissues harboring BRAF(V600E) mutation compared with BRAF wild type (BRAF(WT) ) from collected PTC clinical samples.
genetics_knock down_promote	35651928	hsa-mir-153	Ovarian Neoplasms	3p attenuated the inhibitory influence of knockdown FOXR2 on cisplatin resistance of OC cells.
other	35651814	hsa-mir-483	Carcinoma, Hepatocellular	miR-483 presented the best diagnostic potential because it showed the highest diagnostic accuracy for distinguishing HCV-related HCC patients from controls (AUC = 0.98) with 100% sensitivity.
circulation_biomarker_diagnosis_up	35651814	hsa-mir-335	Carcinoma, Hepatocellular	In conclusion, studied microRNAs (miR-122, miR-483, and miR-335) could serve as potential non-invasive early diagnostic biomarkers for HCC, and we identified a panel of three serum microRNAs with high accuracy in HCC diagnosis.
circulation_biomarker_diagnosis_up	35651814	hsa-mir-122	Carcinoma, Hepatocellular	In conclusion, studied microRNAs (miR-122, miR-483, and miR-335) could serve as potential non-invasive early diagnostic biomarkers for HCC, and we identified a panel of three serum microRNAs with high accuracy in HCC diagnosis.
exosome	35651811	hsa-mir-199a	Osteosarcoma	Exosomal MiR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in Osteosarcoma.
other	35651789	hsa-mir-532	Adenocarcinoma of Lung	Finally, we constructed a ceRNA network that includes hsa-miR5p and four mRNAs (GALNT3, CYCS, EIF5A, and ITGB4) specific to AL139385.1 in LUAD.
circulation_biomarker_diagnosis_up	35651785	hsa-mir-620	Esophageal Neoplasms	Through the Gene Expression Omnibus (GEO) database, miR-620 was selected as a serum miRNA highly expressed in ESCC, but its detailed role in ESCC has not been explored.
circRNA target	35650643	hsa-mir-23a	Carcinoma, Ovarian Epithelial	Furthermore, it revealed that circRHOBTB3 could serve as the ceRNA of miR23a-3p to facilitate PTEN expression, suppress proliferation, G1/S transition, invasion, and promote apoptosis in EOC.
circRNA target	35650603	hsa-mir-449b	Carcinoma, Pancreatic Ductal	CONCLUSIONS: Our findings indicate that circSTX6 facilitates proliferation and metastasis of PDAC cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway.
genetics_knock down_suppress	35650160	hsa-mir-93	Cardiomegaly	Overall, MALAT1 knockdown ameliorated cardiac hypertrophy partly by regulating the miR5p/SIRT4 network, indicating that MALAT1 was a substantial indicator of cardiac hypertrophy.
lncRNA target	35650158	hsa-mir-335	Reperfusion Injury	Moreover, SNHG15 regulated the TLR4/nuclear factor-kappaB (NF-kappaB) signaling pathway through miR
exosome	35649477	hsa-mir-197	Multiple Myeloma	In conclusion, MM-exosomes could inhibit cardiomyocyte viability and promote apoptosis partially through circ-CACNG2/miR3p/caspase3 axis.
circulation_biomarker_diagnosis_ns	35649328	hsa-mir-146a	Lupus Erythematosus, Systemic	We investigated three EV biomarkers, namely, programmed cell death protein-1 (PD-1), microRNA-146a (miRNA-146a) and sialic acid (SA), in serum and urine from SLE patients and healthy controls.
genetics_overexpression_promote	35649317	hsa-mir-520a	Leukemia, Myeloid, Acute	CONCLUSION: Overexpression miR-520a-3p inhibited AML cell proliferation, and promoted apoptosis via inhibiting MUC1 expression and repressing Wnt/beta-catenin pathway activation.
genetics_GWAS	35648632	hsa-mir-1270	Pre-Eclampsia	Our findings suggest that downregulation of miR-1270 contributes to impaired ECFC function via the associated ATM overexpression, which further identifies ATM as a novel and critical factor for ECFC defects in preeclampsia.
genetics_overexpression_promote	35648436	hsa-mir-155	Breast Neoplasms	Despite the great progress in the control of primary tumor growth, metastasis remains the major challenge of breast cancer therapy in clinics, which is highly related to the upregulation of reactive oxygen species (ROS) and overexpression of its relevant pro-survival miR-155 gene. Therefore, we fabricated a poly-antioxidant (FTP) to deliver anti-miR-155 for synergistic treatment of metastatic breast cancer by ROS scavenging and miR-155 inhibition.
lncRNA target	35648221	hsa-mir-26b	Osteosarcoma	RESULTS: CircPVT1 and CCNB1 were significantly upregulated in OS cells, while miR-26b-5p was downregulated. CONCLUSION: Silencing of circPVT1 notably suppressed the tumorigenesis and metastasis of OS via miR-26b-5p/CCNB1 axis.
transcription factor target	35648115	hsa-mir-765	Breast Neoplasms	TRG16, negatively regulated by miR-765, may inhibit the BC progression through regulating BC stem cell-like properties and this inhibition may be mediated by the NF-B pathway.
lncRNA target	35647304	hsa-mir-22	Epilepsy	5p significantly inhibited the TLR4/TRAF6/NF-kappaB-associated inflammation and reduced neuronal apoptosis, suggesting that its induction may be of potential interest for novel antiseizure medications.
target gene	35647303	hsa-mir-1273h	Stomach Neoplasms	miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis.
genetics_overexpression_promote	35647294	hsa-mir-197	Colonic Neoplasms	3p overexpression and DKC1 restoration on regulating CC cell functions and L-OHP resistance.
transcription factor target	35647205	hsa-mir-326	Skin Diseases	3p mimic/inhibitor and siRNA-TLR4 can demonstrate a nonnegligible link between miR
lncRNA target	35647200	hsa-mir-671	Osteoarthritis	These results suggested that DLEU1 acts as one destructive role in OA development via regulating miR
other	35647022	hsa-mir-497	Breast Neoplasms	Thus, the current study aimed to investigate the correlation of miR-497/FGF-23 with neoadjuvant/adjuvant trastuzumab-induced cardiotoxicity in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients. CONCLUSION: The MiR-497/FGF-23 axis serves as a potential indicator predicting trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients.
other	35647022	hsa-mir-497	Cardiotoxicity	Thus, the current study aimed to investigate the correlation of miR-497/FGF-23 with neoadjuvant/adjuvant trastuzumab-induced cardiotoxicity in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients. CONCLUSION: The MiR-497/FGF-23 axis serves as a potential indicator predicting trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients.
circulation_biomarker_diagnosis_up	35646947	hsa-mir-503	Kidney Diseases	CONCLUSION: The serum levels of miRNA
lncRNA target	35646922	hsa-mir-4316	Adenocarcinoma of Lung	Conclusion: Our present research suggested that LUCAT1 facilitate LUAD cell metastasis and glycolysis via serving as a competing endogenous RNA to regulate miR-4316/VEGFA axis, which provided a novel diagnostic marker and therapeutic target for LUAD patients.
lncRNA target	35646686	hsa-let-7f	Colorectal Neoplasms	In summary, FAM222A-AS1, as a novel oncogene in CRC, may promote the CRC progression by inhibiting miR-let-7f/MYH9 axis. The FAM222A-AS1/miR-let-7f/MYH9 signaling pathway may be a novel valuable target for inhibiting CRC.
other	35646670	hsa-mir-101	Adenocarcinoma of Lung	3p and a higher expression of ESPL1, AURKB, BUB3, and FAM83D, were associated with adverse clinical outcomes in patients with LUAD.
other	35646642	hsa-mir-6875	Urinary Bladder Neoplasms	5p, COL6A1, and CDH11, were measured in accordance with DE analysis in LCS-BCa, compared with normal bladder urothelium.
other	35646642	hsa-mir-6784	Urinary Bladder Neoplasms	5p, COL6A1, and CDH11, were measured in accordance with DE analysis in LCS-BCa, compared with normal bladder urothelium.
genetics_overexpression_promote	35646642	hsa-mir-6785	Urinary Bladder Neoplasms	Overexpression of LINC01929 promoted bladder cancer development, while overexpression of miR5p inhibited bladder cancer development.
genetics_overexpression_promote	35646622	hsa-mir-155	high grade glioma	RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group.
genetics_overexpression_promote	35646622	hsa-mir-410	high grade glioma	RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group.
genetics_overexpression_promote	35646622	hsa-mir-181b	high grade glioma	RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group.
genetics_overexpression_promote	35646622	hsa-mir-181a	high grade glioma	RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group.
genetics_overexpression_promote	35646516	hsa-mir-4735	Carcinoma, Renal Cell	3p, and SLC40A1 overexpression significantly attenuated iron overload and ferroptosis in the miR
exosome	35646124	hsa-mir-223	Reperfusion Injury, Renal Ischemia	CONCLUSION: In conclusion, the protective role of BMSC-derived EVs and exosome-delivered miR3p in RIRI was validated.
genetics_knock down_promote	35646117	hsa-mir-653	Thyroid Cancer, Papillary	Knockdown of circNRIP1 attenuated the PTC tumor progression via miR
target gene	35646112	hsa-mir-543	Esophageal Neoplasms	circRNA TCFL5 Promote Esophageal Cancer Progression by Modulating M2 Macrophage Polarization via the miR-543-FMNL2 Axis.
other	35645614	hsa-mir-133a-1	Tendinopathy	CONCLUSIONS: Seven important lncRNAs, particularly MIR133A1HG and C10orf71-AS1, were found associated with tendinopathy according to the lncRNA-associated ceRNA network.
other	35645131	hsa-mir-499	Stomach Neoplasms	Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC).
genetics_GWAS	35645131	hsa-mir-146a	Stomach Neoplasms	Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006).
other	35645131	hsa-mir-196a-2	Stomach Neoplasms	Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC).
transcription factor target	35644411	hsa-mir-27a	Scleroderma, Systemic	MiR-27a-3p/SPP1/ERK1/2 axis may be an important target for delaying the progression of SSc fibrosis.
lncRNA target	35644224	hsa-mir-92b	Stomach Neoplasms	CONCLUSIONS: Circ-MYBL2 may absorb precursor miR-92b in the nucleus to suppress its role in promoting gastric cancer cell proliferation.
lncRNA target	35644004	hsa-mir-141	Reperfusion Injury, Hepatic Ischemia	3p plays a major role in hepatic IRI through the Keap1 signaling pathway, and the present study suggests that miR
lncRNA target	35643814	hsa-mir-25	Glioma	In conclusions, Exo-circBTG2 secreted from RBP-J OE Mphi inhibits tumor progression through the circBTG2/miR3p/PTEN pathway, and circBTG2 is probably a diagnostic biomarker and potential target for glioma therapy.
transcription factor target	35643269	hsa-mir-223	Aortic Aneurysm, Abdominal	loaded nanoparticles targeting macrophage polarization may mitigate AAA progression via downregulating of NLRP3.
other	35642971	hsa-mir-22	Endometrial Hyperplasia	Our findings indicate that balloons coated with PEI/PAA/miR-22 have great potential to be promising DCBs in the treatment of cardiovascular disease.
circulation_biomarker_diagnosis_ns	35642704	hsa-mir-451a	Multiple Myeloma	RESULTS: In the plasma of patients with MM, miR-451a expression was low and IL-6R expression was high.
genetics_overexpression_promote	35642665	hsa-mir-423	Fibrosis, Airway	In summary, overexpression of miR4235P promoted the EMT process in AF by downregulating FOXP4 expression and the underlying mechanism may partly involve activation of the PI3K/AKT/mTOR pathway.
transcription factor target	35642054	hsa-mir-189	Triple Negative Breast Neoplasms	RESULTS: Although c-MYC is not a predicted gene target for miR
circulation_biomarker_diagnosis_up	35641805	hsa-mir-452	Brain Injuries	3p expression; reduced the neurological score; increased blood-brain barrier permeability, brain water content, and neuronal apoptosis; elevated pro-inflammatory factors; and reduced anti-inflammatory factors.
circulation_biomarker_diagnosis_up	35641805	hsa-mir-452	Subarachnoid Hemorrhage	3p expression; reduced the neurological score; increased blood-brain barrier permeability, brain water content, and neuronal apoptosis; elevated pro-inflammatory factors; and reduced anti-inflammatory factors.
genetics_overexpression_promote	35641154	hsa-mir-584	Carcinoma, Non-Small-Cell Lung	Rescue function experiments corroborated that the anticancer activities of TFAP2A AS1 deficient on the oncogenicity of NSCLC cells were reversed by downregulating miR 584 3p or overexpressing CDK4. To sum up, TFAP2A AS1 exhibits cancer promoting roles in NSCLC through the adjustment of miR 584 3p/CDK4 axis.
lncRNA target	35641124	hsa-mir-124	Arthritis, Rheumatoid	OBJECTIVE: This phase 2a randomised, double blind, placebo controlled, parallel group study evaluated the safety and efficacy of a first-in-class drug candidate ABX464 (obefazimod, 50 mg and 100 mg per day), which upregulates the biogenesis of the mRNA inhibitor micro-RNA (miR)-124, in combination with methotrexate (MTX) in 60 patients (1:1:1 ratio) with moderate-to-severe active rheumatoid arthritis (RA) who have inadequate response to MTX or/and to an anti-tumour necrosis factor alpha (TNFalpha) therapy.
lncRNA target	35640631	hsa-mir-590	Stomach Neoplasms	5p, thus inhibiting the progression of GC.
genetics_knock down_promote	35640247	hsa-let-7	Anovulation	To investigate the functional role of lncR17454, dsRNAs of lncR17454 were injected into the hemolymph of 1-d-old third-instar larvae of Bombyx mori, repression of lncR17454 led to molting arrestment during the larval-larval and larval-pupal transition of silkworm, which was consistent to the result as let-7 knockdown in other studies.
other	35639779	hsa-mir-105	Liver Neoplasms	Specifically, in liver and lung cancers, high expression of miR-105 and miR-767 was indicative of poor prognosis.
other	35639779	hsa-mir-767	Liver Neoplasms	Specifically, in liver and lung cancers, high expression of miR-105 and miR-767 was indicative of poor prognosis.
other	35639251	hsa-mir-4697	Ovarian Neoplasms	In the end, we validated the expression, regulation, binding, and effect on chemotherapy response for selected MNX1-AS1/hsa-miR3p/HOXB13 in OC cell lines.
genetics_overexpression_suppress	35639219	hsa-mir-143	Carcinoma, Non-Small-Cell Lung	USP28 overexpression partly overturned the inhibitory effect of miR
other	35639035	hsa-mir-29b	Stomach Neoplasms	Patients with cancer had the lowest expression of miR-29b in stomach body and it was the highest in the patients with inactive gastritis in this location.
other	35639035	hsa-mir-106b	Stomach Neoplasms	Expression of miR-106b in the antrum and body was the highest in the group of cancer patients and the lowest in patients with chronic active gastritis.
other	35638909	hsa-mir-208b	Myocardial Infarction	Results and Conclusion: Several miRNAs were elevated in MI patients, including miR-208b, miR-499, and miR-375.
other	35638909	hsa-mir-499	Myocardial Infarction	Results and Conclusion: Several miRNAs were elevated in MI patients, including miR-208b, miR-499, and miR-375.
genetics_knock down_promote	35638591	hsa-mir-130a	Angelman Syndrome	After that, the knockdown of FAS and overexpression of miR-130a-5p together were observed to aggregate ox-LDL-induced reduction of cell viability and apoptosis, cell cycle progression, cell proliferation, cell migration and invasion.
lncRNA target	35638462	hsa-mir-133b	Pancreatic Carcinoma	Therefore, we propose that targeting the lncRNA-TTN-AS1/miR-133b/SQLE axis is expected to provide new ideas for the clinical treatment of PC patients.
other	35638388	hsa-mir-1290	Asthma	miR-1290 was associated with asthma and atopy during pregnancy (p < 0.05; |B(regression)| >0.2).
lncRNA target	35637792	hsa-mir-19a	Respiratory Syncytial Virus Infections	CONCLUSIONS: These results suggested that the RSV NS1 might play an important role in the pathogenesis of RSV by activating the 5-LO and subsequent inflammatory cytokines through miR-19a-3p.
circulation_biomarker_diagnosis_up	35637648	hsa-mir-15b	Obesity	Circulating miR-15b, Annexin A1, procalcitonin and interleukin-6 levels The present study assessed serum miR-15b, Annexin A1, procalcitonin, and interleukin-6 (IL-6) levels in children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and compared them to these levels in a non-obese healthy control group. In conclusion, determination of serum miR-15b, Annexin A1, and procalcitonin levels could differentiate children with MUO from those with MHO.
lncRNA target	35637630	hsa-mir-27a	Carcinoma, Hepatocellular	Above results suggest that the abnormally over-expressed miR-27a-3p in liver promotes the proliferation of cancer cells and accelerates the development of HCC by targeting inhibition the expression of USP46.
exosome	35637388	hsa-mir-539	Inflammatory Bowel Diseases	CONCLUSION: The present study demonstrated that BMSCs-derived exosomal miR5p suppresses pyroptosis through NLRP3/caspase-1 signalling to inhibit IBD progression.
lncRNA target	35636640	hsa-mir-760	Brain Ischemia	CONCLUSIONS: circNup188 might up-regulate Map3k8 expression through sponging miR
transcription factor target	35636636	hsa-mir-223	Kidney Calculi	CONCLUSION: The expression of miR3p is significantly higher in urinary sEVs derived from CaOx stone patients and may affect stone formation via regulating oxidative stress, focal adhesion and inflammation process.
transcription factor target	35636172	hsa-mir-24	Carcinoma, Renal Cell	Overall, our results suggested that ICS II-induced ferroptosis via the miR3p/GPX4 axis in RCC cells could be a promising therapeutic agent for RCC.
circulation_biomarker_diagnosis_ns	35636162	hsa-let-7a	Pneumonia, Mycoplasma	In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p.
circulation_biomarker_diagnosis_ns	35636162	hsa-mir-150	Pneumonia, Mycoplasma	In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p.
circulation_biomarker_diagnosis_ns	35636162	hsa-let-7b	Pneumonia, Mycoplasma	In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p.
other	35635974	hsa-mir-122	Chemical and Drug Induced Liver Injury	In conclusion, the optimized arrangements of our EIS biosensor system enabled us to detect microRNA-122, a known biomarker for liver injury, as well as three common isoforms to a 1 nM (equivalent to 80 fmole) detection limit.
circulation_biomarker_diagnosis_up	35635855	hsa-mir-125b	Pre-Eclampsia	RESULTS: ET-1 messenger RNA expression levels and immunoreactivity were found significantly higher in the PE group while microRNA-1 and microRNA-125b (miR-125b) levels were significantly decreased in placenta compared to control. miR-125b levels were found significantly higher in maternal and umbilical cord blood samples of the PE group.
lncRNA target	35635748	hsa-mir-524	Thyroid Cancer, Papillary	In addition, NEAT1 promoted PTC development by regulating ID1 expression via sponging miR
lncRNA target	35635083	hsa-mir-378a	Tendinopathy	Our results therefore indicate that targeting the MALAT1/miR-378a-3p/MAPK1 axis may be a promising avenue for the treatment of tendinopathy.
lncRNA target	35635081	hsa-mir-1323	Osteoarthritis	Collectively, the results showed that ZFAS1 promoted chondrocyte proliferation and repressed oxidative stress, possibly by regulating the novel miRNrf2 axis of the inflammation and apoptosis triggered by LPS, indicating that ZFAS1 is a promising therapeutic target for OA.
circulation_biomarker_diagnosis_up	35635080	hsa-mir-532	Cardiomegaly	KaplanMeier and multivariate Cox regression analysis suggested that low ACR predicted overall survival of CHF patients and ACR was inversely correlated with miR-532 across plasma samples.
transcription factor target	35635065	hsa-mir-122	Arthritis	3p represses RA progression by reducing cell viability and increasing synoviocyte apoptosis.
lncRNA target	35635053	hsa-mir-153	Squamous Cell Carcinoma of Head and Neck	3p/AGK axis.Abbreviations: OSCC: Oral squamous cell carcinoma; AGK: Acylgycerol kinase; CircRNA: Circular RNA; KATNAL1: Katanin p60 ATPase-containing subunit A-like 1; qRT-PCR: Quantitative real-time polymerase chain reaction; miRNAs/miRs: MicroRNAs; RIP: RNA immunoprecipitation; 3'UTR3': -untranslated region; HK2: Hexokinase 2; LDHA Lactate dehydrogenase A; IHC: Immunohistochemistry; CCK8: Cell counting kit-8; GAPDH: Glyceraldehyde
other	35635016	hsa-mir-205	Rhinitis, Allergic	miR5p plays a vital role in the inflammation of allergic rhinitis (AR).
other	35634846	hsa-mir-128	Neuroblastoma	3p and TERT represent a novel prognostic biomarker for neuroblastoma.
circulation_biomarker_prognosis_up	35634597	hsa-mir-21	Ovarian Neoplasms	CONCLUSION: Elevated expression of miR-21, HE4, and CA125 in serum is closely associated with the disease status of ovarian cancer.
genetics_knock down_promote	35634507	hsa-mir-1278	Deficiency Diseases	Of those miRNAs that were upregulated with estrogen deficiency and downregulated after estrogen therapy, miR-422a correlated with serum beta-carboxy-terminal type I collagen crosslinks (beta-CTX) and procollagen 1 N-terminal propeptide (P1NP); and miR-1278 correlated with serum beta-CTX, P1NP, osteocalcin, sclerostin, and Dickkopf-1(Dkk1).
exosome	35634460	hsa-mir-155	Heat Stroke	CONCLUSION: Increased miR-155 in microglial exosomes after heat stroke can induce neuronal autophagy via their transfer into neurons. Therefore, miR-155 could be a promising target for interventions of neuronal autophagy after heat stroke.
circRNA target	35634241	hsa-mir-520c	Carcinoma, Non-Small-Cell Lung	RESULTS: The study revealed functional prominence on miR-520c-3p, down-regulated during NSCLC. CONCLUSIONS: The therapeutic usage by designing a synthetic circuit of miR-520c-3p was explored, which may help in suppressing tumors in NSCLC.
lncRNA target	35633990	hsa-mir-802	Breast Neoplasms	In this study, we investigated the probable molecular functions that are related to microRNA-802 (miR-802) and evaluated its prognostic value in breast cancer utilizing bioinformatics tools. Furthermore, representing candidate target genes by prognostic values indicates the potential clinical application of miR-802 in breast cancer.
genetics_GWAS	35633562	hsa-mir-196a-2	Ovarian Neoplasms	So, miR-196a-2 polymorphism can be a possible prognostic factor in ovarian cancer.
genetics_overexpression_suppress	35633539	hsa-mir-191	Carcinoma, Non-Small-Cell Lung	It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer.
genetics_overexpression_suppress	35633539	hsa-mir-24	Carcinoma, Non-Small-Cell Lung	It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer.
genetics_overexpression_suppress	35633539	hsa-mir-133	Carcinoma, Non-Small-Cell Lung	It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer.
genetics_overexpression_suppress	35633539	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer.
other	35633501	hsa-mir-223	Demyelinating Diseases	Herein, we investigated the NLRP3 (NBD-, LRR- and pyrin domain-containing protein 3) inflammasome and its endogenous regulator microRNA3p within the demyelinated CNS in both MS and an animal model of focal demyelination.
other	35633501	hsa-mir-223	Multiple Sclerosis	Herein, we investigated the NLRP3 (NBD-, LRR- and pyrin domain-containing protein 3) inflammasome and its endogenous regulator microRNA3p within the demyelinated CNS in both MS and an animal model of focal demyelination.
lncRNA target	35632705	hsa-mir-28	Hamartoma Syndrome, Multiple	Our results suggest that MINCR might regulate the expression of RAP1B through the inhibition of miR
transcription factor target	35632672	hsa-mir-122	Sveinsson Chorioretinal Atrophy	The increased MIR122HG expression inhibited the production of the antiviral immune-related genes IFN-1, ISG15 and Viperin upon SCRV treatment. Additionally, we found that MIR122HG can promote the replication of SCRV.
other	35632672	hsa-mir-122	Immune System Diseases	In addition, MIR122HG can act as a pivotally negative regulator involved in the MAVS-mediated NF-kappaB and IRF3 signaling pathways, which can effectively avoid an excessive immune response.
target gene	35631544	hsa-mir-145	Ovarian Neoplasms	Peptide Targeted Gold Nanoplatform Carrying miR-145 Induces Antitumoral Effects in Ovarian Cancer Cells.
circulation_biomarker_diagnosis_up	35629399	hsa-mir-486	Prostatic Neoplasms	Our study aimed to assess the applicability of miR-486 in combination with soluble GP88 protein as a diagnostic and/or predictive biomarker for prostate cancer (PCa) patients. Altogether, combined miR-486 and GP88 serum levels are associated with and are therefore suggested as supportive biomarkers for therapy decisions, particularly in elderly PCa patients.
lncRNA target	35628650	hsa-mir-195	Inflammatory Bowel Diseases	In conclusion, our data revealed the role of miR5p in intestinal inflammation in ulcerative colitis, suggesting a potential pharmacological target for new therapeutic approaches.
other	35628433	hsa-mir-22	Uterine Cervical Neoplasms	MiR3p might be a metastamiR, which was gradually further downregulated in SqC-NM &gt; SqC-M &gt; ML-SqC.
genetics_GWAS	35628426	hsa-mir-499	Cardiovascular Diseases	In the STAT cohort, nine SNPs (in the MIR499, CETP, CYP2C9, IL6, ABCC2, PON1, IL10, and VEGFA genes) were associated with lipid traits, three of which were in common with the TN cohort.
genetics_GWAS	35628426	hsa-mir-499a	Cardiovascular Diseases	In the STAT cohort, nine SNPs (in the MIR499, CETP, CYP2C9, IL6, ABCC2, PON1, IL10, and VEGFA genes) were associated with lipid traits, three of which were in common with the TN cohort.
transcription factor target	35628416	hsa-mir-210	Carcinoma, Renal Cell	Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC.
transcription factor target	35628416	hsa-mir-155	Carcinoma, Renal Cell	Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC.
lncRNA target	35628336	hsa-mir-29a	Uterine Cervical Neoplasms	Herein, we established two pairs of parental wild-type (WT) and radioresistant (RR) cervical cancer cells (CaSki and C33A), and we found that constant suppressed miR-29a, but not miR-29b/c, was exhibited in RR-clones that underwent a dose of 6-Gy radiation treatment.
other	35628294	hsa-mir-126	Breast Neoplasms	We have previously shown that physiological delivery of platelet MVs enriched in miR-126 exerted anti-tumor effects in different breast cancer (BC) cell lines.
circulation_biomarker_diagnosis_up	35628259	hsa-mir-370	Sepsis	BAM15 attenuated sepsis as indicated by survival, organ histology (kidneys and livers), spleen apoptosis (activated caspase 3), brain injury (SHIRPA score, serum s100beta, serum miR370-3p, brain miR370-3p, brain TNF-alpha, and apoptosis), systemic inflammation (cytokines, cell-free DNA, endotoxemia, and bacteremia), and blood-brain barrier (BBB) damage (Evan's blue dye and the presence of green fluorescent E.
circulation_biomarker_diagnosis_up	35628259	hsa-mir-370	Sepsis-Associated Encephalopathy	BAM15 attenuated sepsis as indicated by survival, organ histology (kidneys and livers), spleen apoptosis (activated caspase 3), brain injury (SHIRPA score, serum s100beta, serum miR370-3p, brain miR370-3p, brain TNF-alpha, and apoptosis), systemic inflammation (cytokines, cell-free DNA, endotoxemia, and bacteremia), and blood-brain barrier (BBB) damage (Evan's blue dye and the presence of green fluorescent E.
transcription factor target	35628233	hsa-mir-29c	Liver Cirrhosis	The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively.
transcription factor target	35628233	hsa-mir-219a	Liver Cirrhosis	The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively.
transcription factor target	35628233	hsa-mir-22	Liver Cirrhosis	The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively.
other	35628106	hsa-mir-20	Coronary Artery Disease	Among the 14 differentially expressed microRNAs in epicardial fat between patients with and without coronary artery disease, the hsa-miR-320 family was the most highly represented.
other	35627270	hsa-mir-1293	Adenocarcinoma of Lung	CONCLUSIONS: hsa_circ_0008234/hsa-miR3p/SYT1 and hsa_circ_0002360/hsa-miR-1293/ (ADCY9, NMUR1) networks were established, and identified molecules may be involved in pathogenesis and prognosis in patients with LUAD.
other	35627270	hsa-mir-490	Adenocarcinoma of Lung	CONCLUSIONS: hsa_circ_0008234/hsa-miR3p/SYT1 and hsa_circ_0002360/hsa-miR-1293/ (ADCY9, NMUR1) networks were established, and identified molecules may be involved in pathogenesis and prognosis in patients with LUAD.
other	35627262	hsa-mir-101	Carcinoma, Hepatocellular	CONCLUSION: SNHG6 or MALAT1/hsa-miR3p/EZH2 axis were identified as potential regulatory pathways in the progression of HCC.
other	35627259	hsa-mir-143	Colorectal Neoplasms	CONCLUSIONS: miR-143 may be associated with the development of colorectal cancer.
circRNA target	35627232	hsa-mir-205	Lung Neoplasms	This study revealed that hsa_circ_0006692 promoted NSCLC progression via enhancing cell growth, invasion, and metastasis through sponging mir
circulation_biomarker_diagnosis_ns	35627221	hsa-mir-29b	Lung Neoplasms	A total of 132 lung cancer patients and 132 healthy controls were recruited to measure miR-29b and DNMT3B mRNA expression in whole blood.
other	35627132	hsa-mir-4513	Coronary Artery Disease	The study is aimed to investigate the impact of rs895819, rs11614913, and rs2168518 variants in MIR27A, MIR196A2, and MIR4513, respectively, in CAD using allele-specific PCR.
other	35626751	hsa-mir-423	Fibrosis	In addition, miR5p was shown to be involved in HSCs differentiation and hence, fibrosis development.
lncRNA target	35626709	hsa-mir-18a	Breast Neoplasms	A microarray-based gene expression analysis performed in miR-18a over-expressed ER+ breast cancer cell lines demonstrated dysregulation and suppression of immune-related pathways.
exosome	35626040	hsa-mir-625	Carcinoma, Non-Small-Cell Lung	EV-miR5p is an independent biomarker of response and survival in ICI-treated NSCLC patients, in particular in patients with PD-L1 expression >/=50%.
circulation_biomarker_prognosis_ns	35625994	hsa-mir-200c	Breast Neoplasms	Our findings suggest that plasmatic miR-200c-3p levels could be useful for BC staging, while the tumor expression of miR-200c-3p might provide further prognostic information beyond residual disease in BC treated with neoadjuvant chemotherapy.
other	35625926	hsa-mir-140	Endometrial Neoplasms	3-changed their expressions regardless of the chemotherapeutic agent used, which suggests the possibility of their use in monitoring the severity of oxidative stress in endometrial cancer.
other	35625926	hsa-mir-144	Endometrial Neoplasms	3-changed their expressions regardless of the chemotherapeutic agent used, which suggests the possibility of their use in monitoring the severity of oxidative stress in endometrial cancer.
target gene	35625769	hsa-mir-16	Colorectal Neoplasms	Carbonic Anhydrase VIII (CAVIII) Gene Mediated Colorectal Cancer Growth and Angiogenesis through Mediated miRNA 16-5p.
other	35625530	hsa-mir-34a	Alopecia Areata	In conclusion, the MIR34A rs2666433 (A/G) variant is associated with AA risk and severity in the studied population.
other	35625525	hsa-mir-5144	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35625525	hsa-mir-5493	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35625525	hsa-mir-5487	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35625525	hsa-mir-172b	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35625525	hsa-mir-6245	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35625525	hsa-mir-168b	Dehydration	The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade.
other	35624761	hsa-mir-873	Dehydration	In our study, we demonstrate a GNMT and methionine cycle activity restoration by the anti-miR5p that reduces mitochondrial dysfunction and oxidative stress.
other	35624761	hsa-mir-873	Mitochondrial Diseases	5p appears to be an effective therapy against APAP-induced liver injury, where the restoration of GNMT and the methionine cycle may prevent mitochondrial dysfunction while activating hepatocyte proliferative response.
other	35624761	hsa-mir-873	Chemical and Drug Induced Liver Injury	In summary, anti-miR5p appears to be an effective therapy against APAP-induced liver injury, where the restoration of GNMT and the methionine cycle may prevent mitochondrial dysfunction while activating hepatocyte proliferative response.
other	35624629	hsa-mir-21	Neoplasms, Multiple Primary	By monitoring slight increases in miRNA-21 levels, the possibilities of multi-type malignancy can be evaluated more precisely and earlier.
transcription factor target	35624466	hsa-mir-22	Polyposis Syndrome, Hereditary Mixed, 1	Inhibition of miR3p or ectopic MDC1 expression reversed the increased senescence, DNA damage, CIN and defective HR observed in AP4-deficient CRC cells.
transcription factor target	35624466	hsa-mir-22	Colorectal Neoplasms	Inhibition of miR
tissue_expression_ns	35624466	hsa-mir-22	Canavan Disease	AP4-deficiency also sensitized CRC cells to 5-FU treatment, whereas ectopic AP4 conferred resistance to 5-FU in a miR3p and MDC1-dependent manner.
genetics_GWAS	35624451	hsa-mir-31	Prostatic Neoplasms	CONCLUSIONS: Our findings showed that the epigenetic regulator PRMT5 aggravates PCa progression by inhibiting the transcription of CAMK2N1 and is modulated by the circSPON2/miR
exosome	35624329	hsa-mir-144	Reperfusion Injury, Intestinal Ischemia	CONCLUSIONS: BMSC-exos carrying miR
genetics_knock down_promote	35624316	hsa-mir-143	Squamous Cell Carcinoma of Head and Neck	Knockdown of circPVT1 impeded OSCC progression via the miR
lncRNA target	35624111	hsa-mir-494	Spinal Cord Injuries	This study identified a novel KLF2/lncRNA SNHG12/miR3p/RAD23B axis in SNI-induced neuropathic pain, which might provide a new insight for developing novel diagnosis, or therapeutic targets of SCI-induced neuropathic pain in the future.
lncRNA target	35624111	hsa-mir-494	Neuralgia	This study identified a novel KLF2/lncRNA SNHG12/miR3p/RAD23B axis in SNI-induced neuropathic pain, which might provide a new insight for developing novel diagnosis, or therapeutic targets of SCI-induced neuropathic pain in the future.
genetics_overexpression_promote	35623612	hsa-mir-29a	Corneal Injuries	Overexpression of miR-29a and 381-5p significantly prevented M1 phenotype transition in RAW264.7 cells after lipopolysaccharide treatment, suppressed transforming growth factor 1-induced fibrosis marker expression in keratocytes, and reduced scarring after corneal injury.
other	35623291	hsa-mir-199a	Arthritis, Rheumatoid	RESULTS: Data showed that the expression level of MALAT1, H19, miR-199a-5p, and miR3p was significantly higher in the newly diagnosed patients with RA than the healthy subjects, but the increase in the expression level of HSPA5 and MMD genes in the new cases was not significant compared to healthy controls.
other	35623291	hsa-mir-1	Arthritis, Rheumatoid	RESULTS: Data showed that the expression level of MALAT1, H19, miR-199a-5p, and miR3p was significantly higher in the newly diagnosed patients with RA than the healthy subjects, but the increase in the expression level of HSPA5 and MMD genes in the new cases was not significant compared to healthy controls.
lncRNA target	35622250	hsa-mir-1236	Stomach Neoplasms	Our findings suggest that LINC00839 promotes GC progression through sponging miR3p.
transcription factor target	35622214	hsa-mir-338	Glioma	Intriguingly, TPT1suppressed the miR-338 gene, which targets SMO in hESC-NSPCs and BTICs.
transcription factor target	35622213	hsa-mir-377	Squamous Cell Carcinoma of Head and Neck	3p-SESN1-SMAD3 regulatory axis that contributes to proliferation, migration, and invasion in HNSCC development, which may represent an interventional target for HNSCC therapy.
lncRNA target	35621109	hsa-mir-4728	Colorectal Neoplasms	5p as Tumor Suppressors in Pathogenesis of Colorectal MicroRNAs (miRNAs) are a class of small noncoding RNAs that have major functions in the development and progression of colorectal cancer (CRC) as tumor suppressors or oncogenes.
lncRNA target	35621109	hsa-mir-485	Colorectal Neoplasms	5p as Tumor Suppressors in Pathogenesis of Colorectal MicroRNAs (miRNAs) are a class of small noncoding RNAs that have major functions in the development and progression of colorectal cancer (CRC) as tumor suppressors or oncogenes.
other	35620639	hsa-mir-186	Myocardial Infarction	CONCLUSION: Circ_ROBO2 played a promoting role in ox-LDL-induced CMECs injury by sponging miR5p and regulating TRIM14, providing a promising treatment strategy for CAD.
lncRNA target	35620576	hsa-mir-503	Myocardial Reperfusion Injury	It is concluded that miR-503 exacerbated I/R injury via inactivation of PI3K/Akt and STAT3 pathways and may become a therapeutic target in preventing myocardial I/R injury.
other	35620289	hsa-mir-124	Nerve Degeneration	This study is pioneer in elucidating that neuronal miR-124 reshapes microglia plasticity and in revealing the relevance of neuronal survival in mechanisms underlying inflammation in AD-associated neurodegeneration.
genetics_knock down_promote	35620289	hsa-mir-124	Sjogren's Syndrome	Treatment of SWE cells with the miR-124 inhibitor led to RAGE overexpression and loss of neuronal viability, while the mimic caused RAGE/HMGB1 downregulation and prevented mitochondria membrane potential loss.
other	35620289	hsa-mir-124	Alzheimer Disease	We also reported miR-124 colocalization with microglia in AD patient hippocampi. This study is pioneer in elucidating that neuronal miR-124 reshapes microglia plasticity and in revealing the relevance of neuronal survival in mechanisms underlying inflammation in AD-associated neurodegeneration.
circulation_biomarker_diagnosis_ns	35620197	hsa-mir-126	Intestinal Fistula	CONCLUSIONS: These data confirm that circulating MMP9 can be used for the identification of cases with intra-abdominal fistulas and suggest that miR-126 may be also involved in the pathogenesis of this complication and that it may be further investigated as a new therapeutic strategy or for monitoring therapeutic response in these patients.
other	35619921	hsa-mir-93	Esophageal Squamous Cell Carcinoma	5p or the miR-106b-5p-SOCS4 axis may provide great potential in establishing ESCC therapy.
other	35619921	hsa-mir-106b	Esophageal Squamous Cell Carcinoma	5p or the miR-106b-5p-SOCS4 axis may provide great potential in establishing ESCC therapy.
target gene	35619625	hsa-mir-130a	Breast Neoplasms	LncRNA HOTAIR promotes the proliferation and invasion/metastasis of breast cancer cells by targeting the miR-130a-3p/Suv39H1 axis.
genetics_knock down_suppress	35619575	hsa-mir-103a	Colorectal Neoplasms	Additionally, the effect of miR-103a-3p knockdown in CRC cells and the molecular mechanism of miR-103a-3p targeting GREM2 were also studied.
lncRNA target	35619281	hsa-mir-223	Multiple Sclerosis	Our literature research showed that miR-223 could affect different pathways involved in M.S. MiR-223 was also identified as a potential biomarker, distinguishing relapsing-remitting multiple sclerosis (RRMS) from progressive multiple sclerosis (PMS), and thus, it may be an attractive target for further investigations.
lncRNA target	35619019	hsa-mir-520a	uterine corpus endometrial carcinoma	Our studies revealed that VPS9D1-AS1 contributed to the UCEC development and progression by binding to miR-520a-5p competitively and inducing BIRC5 expression, indicating that VPS9D1-AS1 might act as a therapeutic target to develop new therapies for UCEC patients.
genetics_knock down_promote	35618996	hsa-mir-221	Acute Kidney Injury	Finally, knockdown of lncRNA ENSMUST_147219 markedly attenuated the ischemic AKI by targeting the miR
other	35617983	hsa-mir-1228	Carcinoma, Renal Cell	hsa-let-7i-5p/hsa-miR5p-TRIM26-SNRPB was a potential mechanism axis that may play a role on the KIRC cells.
other	35617983	hsa-let-7i	Carcinoma, Renal Cell	hsa-let-7i-5p/hsa-miR5p-TRIM26-SNRPB was a potential mechanism axis that may play a role on the KIRC cells.
other	35617639	hsa-mir-101	Nerve Degeneration	MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown.
other	35617639	hsa-mir-101	Neurotoxicity Syndromes	MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity.
other	35617639	hsa-mir-101	Neurogenic Inflammation	MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity.
other	35617639	hsa-mir-101	Reperfusion Injury	However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown.
other	35617639	hsa-mir-101	Iron Metabolism Disorders	However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown.
circulation_biomarker_diagnosis_up	35617369	hsa-mir-122	Hepatitis C, Chronic	In conclusion, our findings confirm that serum miR-122 levels are significantly upregulated in the HCV cirrhotic patients serving in particular as a biomarker for the non-advanced stages of cirrhosis, independently of the HCV genotype.
circulation_biomarker_diagnosis_ns	35617312	hsa-mir-103a	Larva Migrans, Visceral	We investigated the expression levels of circulating miRNA 21 and miRNA 103a as potential biomarkers for the prediction and diagnosis of toxocariasis in Wistar rats infected with Toxocara canis.Methodology.
circulation_biomarker_diagnosis_ns	35617312	hsa-mir-21	Larva Migrans, Visceral	We investigated the expression levels of circulating miRNA 21 and miRNA 103a as potential biomarkers for the prediction and diagnosis of toxocariasis in Wistar rats infected with Toxocara canis.Methodology.
other	35617207	hsa-mir-22	Brugada Syndrome	3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001).
other	35617207	hsa-mir-423	Brugada Syndrome	3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001).
other	35617207	hsa-mir-23a	Brugada Syndrome	3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001).
other	35617207	hsa-mir-223	Brugada Syndrome	3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001).
lncRNA target	35617032	hsa-mir-185	Colorectal Neoplasms	5p/CCND2 axis may be targetable for CRC diagnosis and therapy.
genetics_overexpression_suppress	35616949	hsa-mir-7a	Diabetic Neuropathies	This study aimed to investigate the mechanism of miR-7a-5p in DPN. CONCLUSION: MiR-7a-5p overexpression ameliorated mitochondrial dysfunction and inhibited apoptosis in DPN by regulating VDAC1/JNK/c-JUN pathway.
genetics_GWAS	35616822	hsa-mir-144	Esophageal Squamous Cell Carcinoma	These data suggest that LINC00886 may act as a tumor suppressor gene in ESCC and its down-regulation through epigenetic mechanisms promotes EMT process via SIRT7/ELF3/miR-144 pathway in ESCC.
circRNA target	35616807	hsa-mir-127	Colorectal Neoplasms	Taken together, these findings indicated that hsa_circ_0006732 might be an oncogene in CRC through the regulation of the miR5p/RAB3D axis.
circulation_biomarker_diagnosis_ns	35616664	hsa-mir-21	Colorectal Neoplasms	OBJECTIVE: This systematic analysis aimed to explore the individual efficacy of the most investigated blood-based miRNAs for CRC diagnosis, namely miR-21, miR-29a and miR-92a. Based on these findings, circulating miR-21 levels may have a potential value for early detection and might be used as a novel diagnostic biomarker for CRC.
transcription factor target	35616621	hsa-mir-342	Glioblastoma	3p/CDK6 might be a treatment target in glioblastoma development.
genetics_overexpression_promote	35616620	hsa-mir-145	Stomach Neoplasms	However, tuftelin 1 overexpression attenuated the tumor-suppressive effect of miR-145 in MGC-803 gastric cancer cells.
lncRNA target	35616619	hsa-mir-942	Nasopharyngeal Carcinoma	3p could sensitize NPC to X-rays via a downstream target BARD1, offering potential new strategies for radiotherapy of NPC.
genetics_overexpression_promote	35616230	hsa-mir-612	Carcinoma, Renal Cell	Migration and invasion of KIRC cells were promoted when the cells were transfected with LINC00174 overexpression or miR-612 inhibitor (p < .05).
lncRNA target	35616155	hsa-mir-2113	Prostatic Neoplasms	The present study demonstrated that MNX1AS1 promoted prostate cancer progression through regulating miR2113/ MDM2 axis.
lncRNA target	35616132	hsa-mir-141	Femur Head Necrosis	In conclusion, miR141 inhibits the osteogenic differentiation of BMSCs in ONFH by targeting E2F3.
lncRNA target	35615948	hsa-mir-145	Colonic Neoplasms	5p repressed colon cancer cell cycle progression and cell proliferation via targeting PSAT1.
exosome	35615580	hsa-mir-342	Myocardial Infarction, Acute	This implies that EV-circITGB1 is involved in dendritic cell maturation and cardiac damage via miR
lncRNA target	35615577	hsa-mir-3200	Carcinoma, Hepatocellular	In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR
lncRNA target	35615577	hsa-mir-3200	Thyroid Cancer, Papillary	In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR
other	35615532	hsa-mir-139	Carcinoma, Hepatocellular	RESULT: SNHG3 was observed to be the most promising upstream lncRNA for the hsa-miR5p/LPCAT1 axis in LIHC.
transcription factor target	35615474	hsa-mir-142	Diabetic Angiopathies	The inhibition of miR
lncRNA target	35615401	hsa-mir-25	Lung Neoplasms	Collectively, our findings show that upregulated PCAT19 suppresses proliferation yet promotes the apoptosis of LC cells through modulating the miR
circulation_biomarker_diagnosis_ns	35615399	hsa-mir-296	Diabetic Nephropathies	In this study, the role of circ_000166/miR-296/SGLT2 in the process of DN-related renal fibrosis was studied by constructing an animal model of DN renal fibrosis via lentiviral transfection, plasmid transfection, and dual-luciferase reporting techniques. We postulate that circ_000166/miR-296/SGLT2 may become a new target in the progression of DN renal fibrosis, and the regulation of this pathway may be a promising strategy for clinical treatment of DN renal fibrosis.
other	35614883	hsa-mir-192	Nephrotic Syndrome	Ultimately, in this study, diabetes led to up-regulation of TGF-beta while troxerutin proved to have a protective effect on the kidney by increasing SIP and lowering miR-192 levels.
other	35614883	hsa-mir-192	Diabetic Nephropathies	Ultimately, in this study, diabetes led to up-regulation of TGF-beta while troxerutin proved to have a protective effect on the kidney by increasing SIP and lowering miR-192 levels.
genetics_knock down_promote	35614065	hsa-mir-199a	Esophageal Squamous Cell Carcinoma	The fractionated irradiation-induced irradiation-resistant cell line KYSE150R was subjected to gain- and loss-of function studies to explore the effect of SOX17 and downstream effectors MALAT1, miR-199a, and HIF1alpha on the malignant phenotypes of ESCC.
circulation_biomarker_prognosis_ns	35614030	hsa-mir-92	Respiratory Distress Syndrome, Newborn	PURPOSE: To explore the value of the expression of serum miR-92 and miR-122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). CONCLUSIONS: The increased expression of serum miR-92 and miR-122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS.
circulation_biomarker_prognosis_ns	35614030	hsa-mir-122	Respiratory Distress Syndrome, Newborn	PURPOSE: To explore the value of the expression of serum miR-92 and miR-122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). CONCLUSIONS: The increased expression of serum miR-92 and miR-122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS.
circulation_biomarker_diagnosis_ns	35613957	hsa-mir-21	Carcinoma, Pancreatic Ductal	A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%.
circulation_biomarker_diagnosis_ns	35613957	hsa-mir-25	Carcinoma, Pancreatic Ductal	A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%.
circulation_biomarker_diagnosis_ns	35613957	hsa-mir-210	Carcinoma, Pancreatic Ductal	A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%.
circulation_biomarker_diagnosis_ns	35613957	hsa-mir-16	Carcinoma, Pancreatic Ductal	A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%.
genetics_overexpression_promote	35613309	hsa-mir-200b	Pre-Eclampsia	Moreover, increased expression of miR-200b-3p was revealed in the placental tissues of preeclampsia patients, and overexpression of miR-200b-3p suppressed cell proliferation and migration but promoted apoptosis of trophoblast cells.
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-125a	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-92b	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-100	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-92a	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-192	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-122	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circulation_biomarker_diagnosis_ns	35613088	hsa-mir-451a	Diabetes, Gestational	Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR
circRNA target	35612554	hsa-mir-149	Squamous Cell Carcinoma of Head and Neck	Inhibition of miR-149 can rescue the inhibitory effects of circ_0014359 knock down on OSCC cells. The circ_0014359-miR-149 pathway may be a novel target for developing strategies for the diagnosis and treatment of OSCC.
circulation_biomarker_diagnosis_ns	35612288	hsa-mir-21	Lung Neoplasms	As a proof of principle, we measure the level of plasma miRNA-21 in 20 lung cancer patients and 10 healthy participants.
genetics_knock down_promote	35611986	hsa-mir-370	Siderosis	Additionally, miR-370 targeting the transferrin receptor protein and upregulated transferrin receptor (TFRC) abolished the effects of overexpressed miR-370 on cell viability and ferroptosis of PDLSCs.
circulation_biomarker_diagnosis_ns	35611880	hsa-mir-181a	Femur Head Necrosis	The results showed a notable decrease in the serum of miR-181a-5p in methylprednisolone-induced ONFH rats.
other	35611851	hsa-mir-155	Hypertension, Pulmonary	miR5p/PYGL pathway was revealed to play a crucial role in PAH by weighted gene co-expression network analysis (WGCNA).
genetics_knock down_promote	35611803	hsa-mir-455	Carcinoma, Non-Small-Cell Lung	Knockdown of CRNDE attenuated NSCLC progression via modulation of the miR
lncRNA target	35611785	hsa-mir-495	Asthma	CONCLUSION: We concluded that FABP5, CXCL3, suppressor of cytokine signaling 3 (SOCS3), E1A binding protein P300 (EP300), NFATc2, microRNA 495 (miR-495), and miR-30 may play important roles in treating asthma.
circRNA target	35611768	hsa-mir-2355	Myocardial Reperfusion Injury	In summary, these results demonstrated circRBMS1 played a protective role in myocardial I/R injury though inhibition of miR
lncRNA target	35611752	hsa-mir-15a	Heart Failure	Nevertheless, the biological role and function of microRNA (miR)-15a in HF are still unknown. Overall, miR-15a could inhibit LX-2 cell viability and HF pathogenesis by targeting SOX9 in vitro and in vivo.
circRNA target	35611720	hsa-mir-30	Leukemia, Myeloid, Acute	CONCLUSION: All these findings revealed that circRNF220 contributed to AML cell development in vitro via upregulating SOX4 expression by targeting miR
lncRNA target	35611706	hsa-mir-181c	Breast Neoplasms	In ESCC cells and tissues, BCAR4 and microRNA -181c-5p (miR-181c-5p) expression, and phosphorylated signal transducer and activator of transcription (p-STAT3) and COX2 expression were evaluated by real-time reverse transcription PCR (qRT-PCR) and Western blot analysis. In conclusion, BCAR4 promotes ESCC tumorigenesis by targeting the miR-181c-5p/LASP1 axis, which may act as a treatment and diagnosis biomarker for ESCC.
lncRNA target	35611706	hsa-mir-181c	Esophageal Squamous Cell Carcinoma	In ESCC cells and tissues, BCAR4 and microRNA -181c-5p (miR-181c-5p) expression, and phosphorylated signal transducer and activator of transcription (p-STAT3) and COX2 expression were evaluated by real-time reverse transcription PCR (qRT-PCR) and Western blot analysis. In conclusion, BCAR4 promotes ESCC tumorigenesis by targeting the miR-181c-5p/LASP1 axis, which may act as a treatment and diagnosis biomarker for ESCC.
genetics_overexpression_promote	35611688	hsa-mir-34c	Hodgkin Disease	Importantly, the number of viable cells in the blood vessels following HLI was increased by miR-34c overexpression.
circulation_biomarker_diagnosis_ns	35611688	hsa-mir-34c	Hypoxia-Ischemia, Brain	Collectively, our findings show that miR-34c plays a protective role in hypoxia, suggesting a novel therapeutic target for hypoxic and ischemic diseases in the blood vessels.
circulation_biomarker_diagnosis_up	35611688	hsa-mir-34c	Ischemia	We identified a hypoxia-induced miRNA, miR-34c, that was significantly upregulated in hypoxic human umbilical cord vein endothelial cells (HUVECs) and in murine blood vessels on day 3 of hindlimb ischemia (HLI).
lncRNA target	35611687	hsa-mir-153	Adenocarcinoma of Lung	3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments.
lncRNA target	35611601	hsa-mir-22	Prostatic Neoplasms	In summary, MIR22HG acts as an anticancer gene in prostate cancer via inhibiting cell proliferation and promoting apoptosis by sponging miR
lncRNA target	35611599	hsa-mir-409	Breast Neoplasms	All these results indicated that miR-409 regulates breast cancer proliferation and invasion by targeting SATB1 and might be a potential therapeutic target for the treatment of breast cancer.
target gene	35611368	hsa-mir-223	Colorectal Neoplasms	Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis.
genetics_overexpression_suppress	35611198	hsa-mir-1246	Colorectal Neoplasms	Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. The downstream genes of miR-1182 and miR-1246 were enriched in some CRC-associated pathways, such as the Wnt signaling pathway.
genetics_overexpression_suppress	35611198	hsa-mir-1182	Colorectal Neoplasms	Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. The downstream genes of miR-1182 and miR-1246 were enriched in some CRC-associated pathways, such as the Wnt signaling pathway.
other	35610981	hsa-mir-155	COVID-19	Also, the method remains sensitive to fM magnitude lung cancer marker (miRNA-155).
other	35610725	hsa-mir-135a	Abortion, Spontaneous	RESULTS: Relative to normal pregnancy (NP), villus tissue samples from pregnancies that ended in unexplained sporadic miscarriage (USM) or unexplained recurrent SA (URSA) exhibited miR-135a-5p upregulation.
circRNA target	35610079	hsa-mir-181a	Keloid	CONCLUSION: Our data showed that circSLC8A1 regulates the miR-181a-5p/HIF1AN axis to restrain HKFs biological functions, confirming that circSLC8A1 might serve as a novel therapeutic target for keloids.
exosome	35609783	hsa-mir-23a	Cardiomyopathies	Prevention of abnormal adipocyte exosome production, inhibition of miR-23a-3p biogenesis, and treatment with a miR-23a-3p antagonist are novel strategies for treating cardiac fibrosis.
circulation_biomarker_diagnosis_ns	35609481	hsa-mir-21	Breast Neoplasms	Under the optimal experimental conditions, the fluorescence system achieved a limit-of-detection of 0.025 amol miR-21 in a 40 muL sample and successfully applied to miR-21 detection in serum samples from breast cancer patients, showing good agreement with the results of RT-PCR, which exhibited great potential in biomedical research and clinical diagnosis.
genetics_overexpression_promote	35609416	hsa-mir-30	Colorectal Neoplasms	Conversely, overexpression of SND1 facilitated the malignant phenotypes of CRC cells and restored miR
circulation_biomarker_diagnosis_ns	35609397	hsa-mir-423	Uterine Cervical Neoplasms	MiR3p was found to be with low expression in the plasma exosomes of patients with CC.
circRNA target	35609334	hsa-mir-1236	Inflammatory Bowel Diseases	Our data confirmed that circ_0001187 facilitated UC progression through miR3p/MYD88 axis, which might be a potential treatment and diagnosis biomarker for UC.
genetics_knock down_promote	35609331	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Taken together, knockdown of lncRNA PCAT6 suppressed the growth of NSCLC cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis.
other	35609320	hsa-mir-1269	Glioblastoma	Overall, miR-1269 is downregulated in GBM and its maturation is regulated by SLC16A1-AS1.
other	35609320	hsa-mir-1296	Glioblastoma	MicroRNA-1269 (miR-1296) promotes esophageal cancer.
target gene	35609318	hsa-mir-582	Carcinoma, Hepatocellular	MicroRNA-582-3p targeting ribonucleotide reductase regulatory subunit M2 inhibits the tumorigenesis of hepatocellular carcinoma by regulating the Wnt/β-catenin signaling pathway.
circRNA target	35609310	hsa-mir-197	Uterine Cervical Neoplasms	CC tumorigenesis was suppressed by OMT via targeting circ_0008460/miR
lncRNA target	35609226	hsa-mir-519d	Pulmonary Disease, Chronic Obstructive	All four were identified as target genes of hsa-miR-519d-3p, which was significantly down-regulated in COPD patients. The results from this study proposed that regulatory network of hsa-miR-519d-3p/CDKN1A, HIF1A, MXD1, and SOD2 closely associated with the progression of COPD, which provides a theoretical basis to link aging effectors with COPD progression, and may suggest new diagnostic and therapeutic targets of this disease.
lncRNA target	35608718	hsa-mir-1297	Acquired Immunodeficiency Syndrome	To explore the role of the miRNA-1297/phospholipase Cbeta1 (PLCbeta1) axis in intestinal barrier injury. miR-1297 could restrain the repair of intestinal barrier injury via negatively regulating PLCbeta1 and its tight junction downstream protein ZO-1 in CCC-HIE-2 cells injured by LPS, which indicated that PLCbeta1 and miR-1297 might be important targets for the repair of intestinal barrier injury.
lncRNA target	35608340	hsa-mir-361	Arthritis, Rheumatoid	5p in both synovial tissues of RA patients and cultured RA-FLS cells.
genetics_overexpression_promote	35608154	hsa-mir-223	Trigeminal Neuralgia	3p overexpression by an intracerebroventricular injection of Lv-miR
other	35608068	hsa-mir-33	Arthritis, Rheumatoid	DISCUSSION AND CONCLUSIONS: Our results suggest that EMS may reduce macrophage polarisation to the M1 inflammatory phenotype by downregulating the miRNA-33/NLRP3 pathway in AA rats.
genetics_overexpression_suppress	35608059	hsa-mir-379	Breast Neoplasms	Overexpression of miR
lncRNA target	35607960	hsa-mir-632	Rectal Neoplasms	Overall, our findings reveal that FEZF1-AS1/miR-632/FAM83A axis plays an oncogenic role in rectal cancer progression, suggesting that it may be a novel therapeutic target for rectal cancer.
lncRNA target	35607443	hsa-mir-532	Colonic Neoplasms	The ceRNA axis MIAT/miR3p/STC1 could serve as a promising therapeutic target for colon adenocarcinoma.
circulation_biomarker_prognosis_up	35607440	hsa-mir-208a	Myocardial Infarction	qRT-PCR assay was carried out to quantify serum miR-208a in the patients and receiver-operating characteristic (ROC) curves for analysing its diagnostic value in AMI patients and its predictive value in clinical efficacy and adverse events in the patients after therapy.
other	35607378	hsa-mir-122	Hearing Disorders	Unveiling the mechanism of miR5p in the mediation of forkhead box O3 (FOXO3) in regards to cochlear hair cell damage provides an effective solution for the treatment of ear hearing disorders.
lncRNA target	35607288	hsa-mir-200c	Diabetic Retinopathy	The objective of this study was to elucidate the underlying molecular mechanisms by which miR-200c-3p regulates the pyroptosis of DR cell. CONCLUSION: The results suggest that miR-200c-3p might be a promising interference target for DR prevention and treatment.
other	35606727	hsa-mir-21	Pancreatic Carcinoma	MiR-10b, miR-21, and GPC1 were the most frequently reported RNA and protein for PC diagnosis.
other	35606727	hsa-mir-10b	Pancreatic Carcinoma	MiR-10b, miR-21, and GPC1 were the most frequently reported RNA and protein for PC diagnosis.
lncRNA target	35606572	hsa-mir-454	Neuroblastoma	3p to up-regulate NEUROD1 expression, deepening our comprehension of lncRNA involved in NB and providing access to the possibility of LINC00839 as a therapeutic target for NB.
transcription factor target	35606547	hsa-mir-122	Aortic Aneurysm, Thoracic	In summary, this study demonstrates that miR-122 in the aortic wall inhibits inflammatory responses and matrix remodeling, which is suppressed by deficient fibrillincell interaction and hypoxia in TAA.
other	35606527	hsa-mir-21	Glioblastoma	Based on miR-21 and miR-10b expression z-scores, approximately 30% of GBM patients were classified as having the GBM BVZ-responsive subtype.
other	35606527	hsa-mir-10b	Glioblastoma	Based on miR-21 and miR-10b expression z-scores, approximately 30% of GBM patients were classified as having the GBM BVZ-responsive subtype.
exosome	35606376	hsa-mir-22	ankylosing spondylitis 1	The current study aimed to elucidate the mechanisms regarding extracellular vesicle (EV)-packaged microRNA
circulation_biomarker_diagnosis_up	35606305	hsa-mir-222	Carcinoma, Hepatocellular	On the other hand, the mean serum value of microRNA 222-3p was significantly raised in the HCC post DAA therapy group than in the control group (P = 0.007), whereas no statistically significant difference was observed between both groups with HCC and between the group with HCV-related HCC without prior exposure to DAAs and control group.
lncRNA target	35605595	hsa-mir-29a	Scleral Diseases	CONCLUSION: MiR-29a inhibits the expression of PTEN, MMP-2, and collagen I on scleral fibroblasts, which may provide a basis studies in sclera.
transcription factor target	35605149	hsa-mir-146a	Diabetic Retinopathy	In summary, miR-146a could inhibit VEGF expression and inflammation in DR.
lncRNA target	35604743	hsa-mir-593	Squamous Cell Carcinoma of Head and Neck	In conclusion, appropriate diagnostic biomarkers and therapies for OSCC can be identified by targeting the TUG1/miR
transcription factor target	35604451	hsa-mir-16	Diabetes Mellitus	"Destabilizing these inflammatory mRNAs by the miR-16 could reduce inflammation. Cholesterol-tagged miR-16 and its mimic are novel anti-inflammatory molecules that can be specifically targeted to, via through CD36 expressing, ""inflamed"" cells and thus serve as therapeutic candidates to alleviate inflammatory diseases."
genetics_overexpression_promote	35604113	hsa-mir-146a	Diabetes Mellitus	The results revealed that overexpression of miR-146a promoted the M2 macrophage polarization by suppressing the TLR4/nuclear factor-kappaB (NF-kappaB) axis, so as to enhance wound healing in diabetic ulcers.
genetics_overexpression_promote	35604113	hsa-mir-146	Diabetes Mellitus	The results revealed that overexpression of miR-146a promoted the M2 macrophage polarization by suppressing the TLR4/nuclear factor-kappaB (NF-kappaB) axis, so as to enhance wound healing in diabetic ulcers.
lncRNA target	35603999	hsa-mir-155	Non-alcoholic Fatty Liver Disease	5p expression to inhibit STC1 expression, thus inducing hepatic mitochondrial dysfunction and promoting the occurrence and development of NAFLD.
lncRNA target	35603775	hsa-mir-613	Polycystic Ovary Syndrome	Therefore, HLA-F-AS1 may inhibit the maturation of miR-613 in PCOS to promote ovarian granulosa cell proliferation and inhibit cell apoptosis.
other	35603556	hsa-mir-3163	Adenocarcinoma of Lung	Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was performed to detect the expression of long non-coding (lnc)RNA AFAP1-AS1, the microRNA (miR)-3163, and secreted phosphoprotein 1 (SPP1) in LUAD tissues, or of A549 and H3122 cells.
transcription factor target	35603476	hsa-mir-29b	Spinal Cord Injuries	After the cells were cultured with EVs without any treatment, uptake of EVs by SCI neurons, miR-29b-3p expression, cell viability, apoptosis, caspase-3, cleaved caspase-3, caspase 9, Bcl-2, PTEN, PI3K, AKT, and p-Akt protein levels, caspase 3 and caspase 9 activities, and inflammatory factors IL-6 and IL-1beta levels were detected by immunofluorescence labeling, RT-qPCR, MTT, flow cytometry, Western blot, caspase 3 and caspase 9 activity detection kits, and ELISA. CONCLUSION: hUC-MSCs-EVs activated the PI3K/AKT pathway by carrying miR-29b-3p into SCI neurons and silencing PTEN, thus reducing neuronal apoptosis.
other	35603405	hsa-mir-218	Osteoarthritis	In potential mRNA-miRNA regulatory network, hsa-miR-449a and hsa-miR5p may be involved in the development of OA.
other	35603405	hsa-mir-449a	Osteoarthritis	In potential mRNA-miRNA regulatory network, hsa-miR-449a and hsa-miR5p may be involved in the development of OA.
transcription factor target	35602576	hsa-mir-585	Ovarian Neoplasms	3p may serve as a potential biomarker and therapeutic target for OC.
circulation_biomarker_diagnosis_up	35602517	hsa-mir-4745	sporatic amyotrophic lateral sclerosis	Among them, the analysis of expression levels of the couple of blood miR-193b/miR
circulation_biomarker_diagnosis_up	35602517	hsa-mir-193b	sporatic amyotrophic lateral sclerosis	Among them, the analysis of expression levels of the couple of blood miR-193b/miR
circulation_biomarker_diagnosis_up	35602517	hsa-mir-193b-1	sporatic amyotrophic lateral sclerosis	Among them, the analysis of expression levels of the couple of blood miR-193b/miR
circulation_biomarker_diagnosis_ns	35602301	hsa-mir-937	Colorectal Neoplasms	To assess the expression levels and predictive usefulness of plasma exosomal hsa-miR-3937 in CRC, we performed RT-qPCR to identify hsa-miR-3937 levels in all samples.
circRNA target	35602296	hsa-mir-583	Colorectal Neoplasms	CONCLUSION: We demonstrated that hsa_circ_0001955 facilitated CRC progression via miR-583/FGF21 axis, suggesting that hsa_circ_0001955 may provide a novel insight for therapy of CRC.
lncRNA target	35602292	hsa-mir-128	Nasopharyngeal Carcinoma	3p, which might serve as a potential therapy target of NPC.
genetics_GWAS	35602094	hsa-mir-299a	Spinal Cord Injuries	The PHLPP1 overexpression of AMPK inhibition with either genetic or pharmacologic methods dramatically abolished the miR-299a-5p agomir-mediated protective effects against SCI.
genetics_overexpression_promote	35601153	hsa-mir-708	Laryngeal Neoplasms	5p overexpression and MALAT1 suppression had synergistic inhibitory effects on the malignant phenotypes of laryngocarcinoma cells and the expression of BRD4, YAP1, and EMT.
genetics_GWAS	35601073	hsa-mir-196a	COVID-19	The present study investigated the association of the ACE2 rs4343 G>A and miR-196a2 rs11614913 C>T gene polymorphisms with severity and mortality of COVID-19 using amplification refractory mutation system PCR in 117 COVID-19 patients and 103 healthy controls from three regions of Saudi Arabia. The results also showed that the CT genotype and T allele of the miR-196a2 rs11614913 C>T were associated with decreased risk to COVID-19 with OR=0.76, P=0.006 and OR=0.54, P=0.005, respectively.
other	35601073	hsa-mir-196	COVID-19	Gene variations of ACE2 and microRNA (miR)-196 are associated with viral infection and other diseases.
circRNA target	35600959	hsa-mir-145	Adenocarcinoma of Lung	Circ_0001998 regulates the proliferation, invasion, and apoptosis of LUAD via sponging miR-145.
lncRNA target	35600767	hsa-mir-134	Neurotic Disorders	CONCLUSION: These data provide strong evidence that Rb1 rescued CUMS-induced depression-like effects by modulating hippocampal synaptic plasticity via the miRmediated BDNF signaling pathway.
circulation_biomarker_diagnosis_ns	35600587	hsa-mir-6891	Intrahepatic Cholestasis of Pregnancy	5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR
circulation_biomarker_diagnosis_ns	35600587	hsa-mir-4271	Intrahepatic Cholestasis of Pregnancy	5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR
circulation_biomarker_diagnosis_ns	35600587	hsa-mir-1275	Intrahepatic Cholestasis of Pregnancy	5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR
genetics_overexpression_suppress	35600383	hsa-mir-195	Adenocarcinoma of Lung	5p, and overexpression of miRNA
circulation_biomarker_diagnosis_ns	35600346	hsa-mir-371a	Seminoma	Serum levels of microRNA-371a-3p (M371) involve high specificity and sensitivity for the primary diagnosis of seminoma.
genetics_knock down_promote	35600345	hsa-mir-133a	Colorectal Neoplasms	RP9P knockdown decreased FOXQ1 expression levels in CRC cells by directly targeting miR-133a-3p via a sponge mechanism.
other	35600155	hsa-mir-9	Angelman Syndrome	Circ_0090231 could attenuate ox-LDL-mediated HUVEC damage by the miR5p/TXNIP axis, providing a promising therapeutic strategy for AS treatment.
genetics_knock down_promote	35600150	hsa-mir-22	Sepsis	3p/CXCL12/NF-kappaB signaling pathway, suggesting that NEAT1 knockdown might be a potential pathway for alleviating sepsis-induced AKI.
genetics_knock down_promote	35600150	hsa-mir-22	Acute Kidney Injury	3p/CXCL12/NF-kappaB signaling pathway, suggesting that NEAT1 knockdown might be a potential pathway for alleviating sepsis-induced AKI.
other	35600044	hsa-mir-9	Carcinoma, Hepatocellular	5p-mediated downregulation of TSPAN9 was associated with poor HCC prognosis, immune-related signaling pathway, and tumor immune infiltration.
other	35599631	hsa-mir-19a	Colorectal Neoplasms	Thus, we proposed a novel mechanism of ferroptosis mediated by miR-19a in CRC cells, which could give rise to a new strategy for the therapy of CRC.
transcription factor target	35599617	hsa-mir-663	Plaque, Atherosclerotic	This study probed into the function of miR-663 in AS. CONCLUSION: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment.
transcription factor target	35599617	hsa-mir-663	Atherosclerosis	This study probed into the function of miR-663 in AS. CONCLUSION: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment.
transcription factor target	35599576	hsa-mir-27b	Sepsis	Therefore, this study revealed that Chrysophanol guarded against sepsis-mediated acute myocardial injury through dampening inflammation and apoptosis via the miR-27b-3p-PPARG axis, adding to the references for treating sepsis-AMI.
transcription factor target	35599576	hsa-mir-27b	Myocardial Infarction, Acute	Therefore, this study revealed that Chrysophanol guarded against sepsis-mediated acute myocardial injury through dampening inflammation and apoptosis via the miR-27b-3p-PPARG axis, adding to the references for treating sepsis-AMI.
lncRNA target	35599572	hsa-mir-524	Diabetic Retinopathy	Taken together, suppressing TUG1 impairs vascular function in diabetic retinas via controlling miR5p and FGFR2, suggesting a possible therapy method for DR.
genetics_overexpression_promote	35599447	hsa-mir-485	Carcinoma, Non-Small-Cell Lung	RRM2 overexpression partly reversed miR-200c-3p or miR
genetics_overexpression_promote	35599447	hsa-mir-200c	Carcinoma, Non-Small-Cell Lung	RRM2 overexpression partly reversed miR-200c-3p or miR
circulation_biomarker_diagnosis_up	35599383	hsa-mir-21	Colorectal Neoplasms	The present nano-genosensor shows superior performance for miR-21 in human serum samples and demonstrates a potential application for the diagnosis of early stage colorectal cancer.
lncRNA target	35599309	hsa-mir-4428	Carcinoma, Non-Small-Cell Lung	Finally, in vitro and in vivo assays jointly validated that LINC01806 exerted its function in NSCLC development via miR-4428/NOTCH2 pathway. CONCLUSION: LINC01806 enhanced NOTCH2 expression to stimulate Notch signaling via sponging miR-4428, thereby facilitating NSCLC progression, which provided a novel mechanism for NSCLC therapeutic approaches.
circulation_biomarker_diagnosis_ns	35599275	hsa-mir-4467	Schizophrenia	5p and miR-4467 hold promise in blood diagnosis for SCZ, and miR
circulation_biomarker_diagnosis_ns	35599275	hsa-mir-9	Schizophrenia	5p and miR-4467 hold promise in blood diagnosis for SCZ, and miR
other	35598655	hsa-mir-200a	Alzheimer Disease	Although the idea of sponging of miRNAs by lncRNAs in other pathologies is gradually gaining credibility, this novel MALAT1- miR-200a/26a/26b - EPHA2 regulation mechanism in the context of AD pathophysiology promises to become a significant strategy in controlling the disease.
circulation_biomarker_diagnosis_up	35598633	hsa-mir-124	Lupus Erythematosus, Systemic	3p was an independent predictor for SLE, and the plasma miR
circulation_biomarker_diagnosis_up	35598633	hsa-mir-377	Lupus Erythematosus, Systemic	3p was an independent predictor for SLE, and the plasma miR
exosome	35598413	hsa-mir-455	Hippocampal Neuronal   Injury	CONCLUSION: MSCs-derived exosomal miR
transcription factor target	35598381	hsa-mir-9	Glioma	GSC-derives EVs could promote GBM growth and migration Moreover, inhibition of miR-9 in GSCs showed the reverse anti-tumor effects through secreted EVs.
lncRNA target	35598218	hsa-mir-183	Thyroid Cancer, Papillary	Collectively, our findings suggest that circ_FAM53B affects PTC cell biological behaviors via the miR5p-CCDC6 axis.
other	35597927	hsa-mir-182	Hyperphosphatemia	RNA-seq analysis of HP-EC-EVs illustrated that one known miR (hsa-miR-3182) was statistically up-regulated and twelve miRs were significantly down-regulated, which was verified by qRT-PCR.
genetics_knock down_promote	35597500	hsa-mir-1178	Breast Neoplasms	The inhibition of miR-1178 and overexpression of PRMT7 reversed the effect of circ_0039960 knockdown on BC cell growth and Warburg effect.
lncRNA target	35597494	hsa-mir-145	Atherosclerosis	5p and then activating autophagy in HAVSMCs through the AMPK/mTOR/ULK1 signalling pathway to affect the AS progress.
genetics_knock down_promote	35597301	hsa-mir-136	Carcinoma, Renal Cell	5p was increased, and MAT2B expression was decreased after CYTOR knockdown, thereby inhibiting the development of RCC.
genetics_overexpression_promote	35597125	hsa-mir-4742	Stomach Neoplasms	5p expression, whereas overexpression of miR
transcription factor target	35596947	hsa-mir-44438	Parkinson Disease	The miRNA, novel_miR_44438, was significantly increased in the PD group, which promoted alpha-syn accumulation and neuronal degeneration in a dose-dependent manner. INTERPRETATION: Novel_miR_44438 in PD-derived L1CAM-purified EVs inhibits the alpha-syn efflux from neurons thereby promoting the pathological accumulation and aggregation of alpha-syn.
other	35596257	hsa-let-7a	Pre-Eclampsia	CONCLUSIONS: High let-7a and IFN-gamma expressions were correlated with clinical features, and could be used as biomarkers for treatment and poor prognosis of PECsf.
other	35596173	hsa-mir-15a	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-223	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-15b	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-34a	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-16	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-126	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-106a	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596173	hsa-mir-129-2	Diabetes Mellitus, Type 2	METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126.
other	35596172	hsa-mir-675	Colorectal Neoplasms	This study aims to investigate the role of the hypoxia-induced miR5p in 5-Fluorouracil (5-FU) resistance on colorectal cancer (CRC) cells.
virus_miRNA	35596131	hcmv-mir-US33	Acute Aortic Dissection	HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway
circulation_biomarker_diagnosis_ns	35596051	hsa-mir-642	Pancreatic Carcinoma	METHODS AND RESULTS: In the current study, we assessed expression levels of miR-8073 and miR-642 in the circulation of 50 patients with pancreatic cancer and 50 controls. Plasma levels of miR-8073 and miR-642 were significantly higher in patients with pancreatic cancer compared with controls (P value < 0.0001 and P value = 0.0068, respectively).
genetics_overexpression_suppress	35595956	hsa-mir-133	Arthritis, Rheumatoid	Overexpression of miR-133 reduced cell viability and migration of RA FLS, with decreased levels of FSCN1, EGFR, and MET.
other	35595718	hsa-mir-200	Colorectal Neoplasms	This was driven by miR-200 (miR-200a/b/c, -141), which was enriched in epithelial CRC EVs and transferred to recipient fibroblasts. Supporting these findings, there was a strong negative correlation between miR-200 and myofibroblastic markers in a cohort of CRC patients in the TCGA dataset.
other	35595039	hsa-mir-223	Inflammatory Bowel Diseases	In conclusion, our study provided a novel protective impact for MFE against UC, in which miRNA-223 and TNFalpha/NFkappaB/NLRP3 pathway are involved.
other	35594893	C19MC cluster	Carcinoma, Embryonal	METHODS: The authors evaluated 4 patients with ETMR at their institution who showed varied clinical features and also conducted clinical characterization and prognostic analysis of previously reported cases of the ETMR-presenting locus 19q13.42 with a chromosome 19 microRNA cluster (C19MC) amplification, which is known to be a diagnostic hallmark of the tumor.
lncRNA target	35594842	hsa-mir-10b	Glioblastoma	(2022) demonstrates how two long non-coding RNAs (lncRNAs) link a distal enhancer to the HOXD3/D4/miR-10b gene promoter, leading to transcriptional activation of the therapeutic target miR-10b in glioblastoma multiforme.
circulation_biomarker_diagnosis_up	35594307	hsa-mir-199a	Acquired Immunodeficiency Syndrome	Our findings suggest that even though ART uptake and viral suppression might help in maintaining miR3181 and miR199a levels in the placenta of women with HIV at comparative levels to those of their HIV negative counterparts, the significantly higher levels of miR-199a in the plasma of women with HIV compared to the placenta might highlight lurking systemic dangers and requires further investigation.
circulation_biomarker_diagnosis_ns	35594307	hsa-mir-3181	Acquired Immunodeficiency Syndrome	There was no significant difference in the levels of miR-3181 (p>0.05) in the placenta and plasma amongst HIV-infected and HIV uninfected women.
other	35593591	hsa-mir-619	Carcinoma, Squamous Cell, Cutaneous	Circ_TNFRSF21 and ROCK2 were upregulated in cSCC tissue, while miR5p was downregulated.
transcription factor target	35593587	hsa-mir-181b	Cardiovascular Diseases	Collectively, this study unveils an important role of miR-181b in regulating vascular endothelial aging via an MAP3K3-MAPK signaling pathway, providing new potential therapeutic targets for antiaging therapy in CVD.
tissue_expression_ns	35593504	hsa-mir-382	Pneumonia	LINC00707 deficiency could relieve LPS-triggered WI-38 cell damage by regulating the miR5p/NKAP axis, providing a new therapeutic strategy for IP treatment.
other	35593364	hsa-mir-124	Tetralogy of Fallot	CONCLUSION: Hsa-mir-16 and hsa-mir-124 are the key miRNAs of TOF, which mainly regulate the expression of NT5DC1, ECHDC1, HSDL2, FCHO2, and ACAA2 involved in the conversion of ATP in the mitochondria and the metabolic rate of fatty acids (FA).
other	35593364	hsa-mir-16	Tetralogy of Fallot	CONCLUSION: Hsa-mir-16 and hsa-mir-124 are the key miRNAs of TOF, which mainly regulate the expression of NT5DC1, ECHDC1, HSDL2, FCHO2, and ACAA2 involved in the conversion of ATP in the mitochondria and the metabolic rate of fatty acids (FA).
other	35593324	hsa-mir-21	Osteoporosis	BMD, BALP, BGP, and miR-21 levels in OVX rats were decreased.
lncRNA target	35593126	hsa-mir-6838	Nasopharyngeal Carcinoma	CONCLUSION: CircKIAA0368 upregulates HOXA10 expression via miR
transcription factor target	35593122	hsa-mir-744	Osteosarcoma	5p is a negative regulator of TGFB1 and suppresses OS progression and metastasis via the p38 MAPK signaling pathway.
lncRNA target	35592920	hsa-mir-103	Muscular Atrophy	Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR
lncRNA target	35592920	hsa-mir-205	Muscular Atrophy	Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR
lncRNA target	35592920	hsa-mir-23a	Muscular Atrophy	Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR
other	35592680	hsa-mir-4435-2	Adenocarcinoma of Lung	Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD.
other	35592680	hsa-mir-125a	Adenocarcinoma of Lung	Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD.
other	35592674	hsa-mir-20b	Ovarian Neoplasms	In our study, ceRNA networks including miR-320b and miR-320d probably provided novel insights for platinum resistance in ovarian cancer patients.
other	35592674	hsa-mir-320d	Ovarian Neoplasms	In our study, ceRNA networks including miR-320b and miR-320d probably provided novel insights for platinum resistance in ovarian cancer patients.
lncRNA target	35592615	hsa-mir-124	Incontinentia Pigmenti	Moreover, inhibiting miR
other	35592536	hsa-mir-361	Uterine Cervical Neoplasms	5p/TNF regulatory axis, which may play a vital role in the progression of cervical cancer.
transcription factor target	35592504	hsa-mir-23b	Alzheimer Disease	In the present study, we investigated the potential therapeutic effects and mechanisms of miR-23b-3p in AD. Collectively, our findings strongly support the hypothesis that miR-23b-3p plays a neuroprotective role in AD, thereby identifying miR-23b-3p as a promising therapeutic target for AD.
lncRNA target	35592503	hsa-mir-145a	Myocardial Infarction	In summary, circERBB2IP can promote angiogenesis after myocardial infarction through the miR-145a-5p/Smad5 axis.
target gene	35592388	hsa-mir-140	Osteosarcoma	LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway.
lncRNA target	35592246	hsa-mir-545	Carcinoma, Hepatocellular	Collectively, our data revealed that circFGGY inhibits the proliferation and invasion of HCC cells by sponging miR3p and promote the expression of Smad7, indicating that circFGGY functions as a tumor suppressor and could be a prognostic biomarker for HCC.
other	35592126	hsa-mir-4739	Stomach Neoplasms	The expression level of miR-4739 has certain diagnostic value for patients with GC, and the prognosis of patients in LE group was worse than that in HE group.
other	35592108	hsa-mir-506	Stomach Neoplasms	LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer.
target gene	35591840	hsa-mir-145	Stomach Neoplasms	5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone up-regulates miR-145 expression and inhibits proliferation of gastric cancer cells.
lncRNA target	35591837	hsa-mir-485	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: LINC01296 promote the cell cycle, proliferation, migration and invasion, and inhibit apoptosis of OSCC cells through activating the MAPK/ERK signaling pathway via sponging miR
lncRNA target	35591820	hsa-mir-125b	Polycystic Ovary Syndrome	CONCLUSIONS: Since miR-125b controls the proliferation rate of granulosa cells in polycystic ovaries, it might be addressed as a potential therapeutic target for PCOS patients.
genetics_overexpression_promote	35591810	hsa-mir-221	Depression	3p overexpression or Gab1 downregulation reversed the role of silencing METTL3 in CUMS rats.
other	35590240	hsa-mir-214	Liver Neoplasms	5p may be potential gene signatures related to liver cancer hypoxia.
other	35590240	hsa-mir-296	Liver Neoplasms	5p may be potential gene signatures related to liver cancer hypoxia.
other	35590240	hsa-mir-483	Liver Neoplasms	5p may be potential gene signatures related to liver cancer hypoxia.
other	35590240	hsa-mir-4739	Liver Neoplasms	5p may be potential gene signatures related to liver cancer hypoxia.
genetics_overexpression_promote	35590122	hsa-mir-6511b	Colorectal Neoplasms	In vitro, overexpression of miR-6511b-5p inhibited metastasis by decreasing CD44 expression via directly targeting BRG1 in colorectal cancer.
circulation_biomarker_diagnosis_up	35590121	hsa-mir-27a	Obesity	RESULTS: The study results revealed that miR-27a was upregulated in the plasma of MetS group compared to the healthy controls, while miR-320a was downregulated (p </= 0.005).
circulation_biomarker_diagnosis_up	35590121	hsa-mir-20a	Obesity	RESULTS: The study results revealed that miR-27a was upregulated in the plasma of MetS group compared to the healthy controls, while miR-320a was downregulated (p </= 0.005).
genetics_GWAS	35590046	hsa-mir-1256	Stomach Neoplasms	CONCLUSION: Knockdown of circ_0003506 suppressed radioresistance in GC through the regulation of miR-1256/bone morphogenetic protein type 2 receptor axis.
genetics_overexpression_promote	35589691	hsa-mir-7a	Parkinson Disease	We found that circ-Pank1 could adsorb miR-7a-5p and upregulate the expression of alpha-synuclein (alpha-syn), which is a molecular hallmark closely related to PD. In conclusion, circ-Pank1 is overexpressed in PD and enhances the locomotor dysfunction via the miR-7a-5p/alpha-syn signaling axis.
exosome	35589002	hsa-mir-1290	Brain Neoplasms	Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis.
exosome	35589002	hsa-mir-1290	Breast Neoplasms	Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis.
exosome	35589002	hsa-mir-1246	Brain Neoplasms	Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis.
exosome	35589002	hsa-mir-1246	Breast Neoplasms	Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis.
circulation_biomarker_diagnosis_up	35588895	hsa-mir-223	Venous Thrombosis	RESULTS: The levels of 22 circulating plasma miRNAs (12 up-regulated, 10 down-regulated) were significantly changed in patients with DVT before and after endovascular interventions, especially miR-125a-5p (up-regulation) and miR
circulation_biomarker_diagnosis_up	35588895	hsa-mir-125a	Venous Thrombosis	RESULTS: The levels of 22 circulating plasma miRNAs (12 up-regulated, 10 down-regulated) were significantly changed in patients with DVT before and after endovascular interventions, especially miR-125a-5p (up-regulation) and miR
circulation_biomarker_diagnosis_ns	35588772	hsa-mir-146a	Fetal Alcohol Spectrum Disorders	Our findings suggested that certain phthalates exposure was related to plasma miRNAs alterations in a dose-response manner and miR-146a might partly mediate phthalate-associated ABI reduction.
circulation_biomarker_diagnosis_down	35588695	hsa-mir-142	Acute Lung Injury	Collectively, serum-derived EVs-loaded miR5p downregulated PTEN and activated PI3K/Akt to inhibit ALI in sepsis following RIPC, thus highlighting potential therapeutic molecular targets against ALI in sepsis.
genetics_overexpression_promote	35588441	hsa-mir-223	Carcinoma, Non-Small-Cell Lung	3p inhibition or PTN overexpression might reverse the inhibitory effects of PITPNA-AS1 suppression on LUSC progression, as demonstrated by rescue experiments.
lncRNA target	35588255	hsa-mir-135b	Pre-Eclampsia	Therefore, miR-135b-5p may regulate trophoblast function by targeting PIK3R2 in PE and could serve as a novel therapeutic target for PE.
lncRNA target	35587844	hsa-mir-195	Colorectal Neoplasms	5p could be used as a tumor suppressor in colorectal cancer (CRC).
lncRNA target	35587748	hsa-mir-128	Colorectal Neoplasms	Altogether, our results showed that LINC00467 contributes to CRC progression and angiogenesis via the miR
other	35587747	hsa-mir-203a	Endometriosis	It is also suggested that miR-203a-3p, ABL1, and TP63 might be candidate factors for the pathogenesis of endometriosis and suggesting its therapeutic potential in endometriosis.
circulation_biomarker_diagnosis_up	35587745	hsa-mir-20a	Fibromyalgia	METHODS: The included patients were subjected to detailed history taking, assessment of severity of fibromyalgia symptoms using the Fibromyalgia Impact Questionnaire Revised (FIQR), assessment of pain intensity using the Neuropathic Pain Symptom Inventory (NPSI), measurement of the serum level of miR-320a in addition to of measurement peak latencies and amplitudes of middle latency SSEPs.
lncRNA target	35587661	hsa-mir-100	Arthritis, Temporomandibular	5p) on mammalian target (mTOR) of rapamycin in temporomandibular arthritis.
genetics_overexpression_promote	35587154	hsa-mir-644	Stomach Neoplasms	Overexpression of circPFKP enhances the expression of ADAMTSL5 by decreasing the expression of miR-644 to suppress the growth of xenograft GC tumors in vivo and in vitro. In conclusion, the circPFKP/miR-644/ADAMTSL5 regulatory pathway inhibited the malignant progression of GC.
lncRNA target	35587058	hsa-mir-572	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: MiR-572 is closely linked to metastasis and prognosis in NSCLC patients, and it promotes the malignant development of NSCLC via targeting KLF2.
circulation_biomarker_diagnosis_up	35586674	hsa-mir-155	Osteoarthritis, Knee	Lysholm knee joint score scale and osteoarthritis index (WOMAC) scale of Western Ontario and McMaster University were used to evaluate the knee joint function of the two groups, and the levels of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), serum superoxide dismutase (SOD), serum malondialdehyde (MDA), serum miR-155, and NLRP3 were detected in the two groups, and the comprehensive quality of life assessment questionnaire-74 was used, and the adverse reactions were compared between the two groups.
other	35586205	hsa-mir-205	Liver Neoplasms	DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p.
other	35586071	hsa-mir-25	Tuberculosis	This study demonstrates that the role of miR-25 during Mtb infection contributes to a better understanding of the pathogenesis of tuberculosis (TB).
lncRNA target	35586052	hsa-mir-21	Corneal Neovascularization	Collectively, our results suggested that targeting HMGB1-NFkappab axis and miR-21 by GLY could introduce a therapeutic approach to counter CNV.
transcription factor target	35585990	hsa-mir-382	Fibrosis, Renal	However, whether miR-382 is implicated in macrophage activation in AA-induced kidney fibrosis remains elusive. Taken together, our data suggest that miR-382 is a critical mediator in M2-like macrophage polarization and can be a promising therapeutic target for kidney fibrosis.
lncRNA target	35585935	hsa-mir-222	Melanoma	In addition, inhibition of miR
other	35585886	hsa-mir-106a	Carcinoma, Hepatocellular	Moreover, miR3p and miR-106a-5p significantly increased the ROS level and stagnated cell cycle at G2/M in HCC; the results were more obvious in cells after ionizing radiation (IR).
other	35585886	hsa-mir-210	Carcinoma, Hepatocellular	Moreover, miR3p and miR-106a-5p significantly increased the ROS level and stagnated cell cycle at G2/M in HCC; the results were more obvious in cells after ionizing radiation (IR).
other	35585716	hsa-mir-877	Adenocarcinoma of Lung	Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD.
other	35585716	hsa-mir-29c	Adenocarcinoma of Lung	Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD.
other	35585716	hsa-mir-103b	Adenocarcinoma of Lung	Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD.
exosome	35585044	hsa-mir-342	Liver Cirrhosis	Altogether, our study proved that silence of NEAT1 in the macrophage exosomes exerted protective roles against HF through the miR-342/Sp1/TGF-beta1/Smad signaling pathway, suggesting a potential therapeutic target in HF treatment.
lncRNA target	35584745	hsa-mir-27a	Reperfusion Injury, Cerebral Ischemia	Furthermore, miR-27a-3p mimic could relieve cerebral infarct and neurologic deficit after CIR. Taken together, our results suggest that miR-27a-3p protects against CIR by relieving inflammation, neuronal damage, and neurologic deficit via regulating LITAF and the TLR4/NF-kappaB pathway.
lncRNA target	35584745	hsa-mir-27a	Inflammation	Furthermore, miR-27a-3p mimic could relieve cerebral infarct and neurologic deficit after CIR. Taken together, our results suggest that miR-27a-3p protects against CIR by relieving inflammation, neuronal damage, and neurologic deficit via regulating LITAF and the TLR4/NF-kappaB pathway.
other	35583533	hsa-mir-421	Stomach Neoplasms	These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC.
other	35583533	hsa-mir-223	Stomach Neoplasms	These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC.
other	35583533	hsa-mir-21	Stomach Neoplasms	These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC.
other	35583533	hsa-mir-106	Stomach Neoplasms	These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC.
other	35583104	hsa-mir-515	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
other	35583104	hsa-mir-604	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
other	35583104	hsa-let-7d	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
other	35583104	hsa-mir-29a	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
other	35583104	hsa-mir-590	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
other	35583104	hsa-mir-24	Allograft Rejection, Antibody-Mediated	3p and miR-29a-3p were downregulated.
genetics_overexpression_promote	35583065	hsa-mir-335	Triple Negative Breast Neoplasms	Overexpression of miR
lncRNA target	35583006	hsa-mir-223	Pulmonary Disease, Chronic Obstructive	The present study concluded that lncRNA GAS5 promoted pyroptosis in COPD by targeting the miR2233p/NLRP3 axis, implying that GAS5 could be a potential target for COPD.
lncRNA target	35583000	hsa-mir-142	Neuralgia	In summary, the present study demonstrated that SNHG5 silencing could alleviate the neuropathic pain induced by chronic constriction injury via sponging miR1425p and regulating the expression of CAMK2A.
lncRNA target	35582879	hsa-mir-206	Hepatitis C	In conclusion, miR-206 could inhibit HCV proliferation through depressing ACC1 lipogenesis pathway and decreasing the lipid droplet numbers.
genetics_knock down_promote	35582765	hsa-mir-378a	Inflammatory Bowel Diseases	After loss- and gain-of-function assays, the regulatory role of MSCs-derived EVs loaded with manipulated miR-378a-3p in IBD in relation to GATA2/AQP4/PPAR-alpha were explored.
genetics_overexpression_promote	35582664	hsa-mir-15b	Diabetic Nephropathies	miR-15b-5p inhibition or TLR4 overexpression averted the inhibitory effect of silencing XIST on HG-induced RTEC pyroptosis.
other	35582589	hsa-mir-126	Colonic Neoplasms	The aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy. Conclusion: MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy.
other	35582584	hsa-mir-203	Breast Neoplasms	miR-200c and miR-203 exert a negative modulating effect on the activity of ABCB1 associated with doxorubicin resistance
other	35582584	hsa-mir-200c	Breast Neoplasms	miR-200c and miR-203 exert a negative modulating effect on the activity of ABCB1 associated with doxorubicin resistance
other	35582270	hsa-mir-16	Mesothelioma, Malignant	Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells.
other	35582270	hsa-mir-15a	Mesothelioma, Malignant	Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells.
other	35582270	hsa-mir-34a	Mesothelioma, Malignant	Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells.
lncRNA target	35582235	hsa-mir-126	Cerebral Hemorrhage	CONCLUSION: miR-126 is downregulated in ICH rats, and miR-126 can reduce brain injury in ICH rats by inhibiting ZEB1 expression.
lncRNA target	35582235	hsa-mir-126	Brain Injuries	CONCLUSION: miR-126 is downregulated in ICH rats, and miR-126 can reduce brain injury in ICH rats by inhibiting ZEB1 expression.
circulation_biomarker_diagnosis_up	35582197	hsa-mir-27b	Carcinoma, Non-Small-Cell Lung	Serum exosomal miR-27b was diminished in NSCLC and was further decreased in the NSCLS-terminal group.
genetics_knock down_promote	35582196	hsa-mir-1258	Carcinoma, Non-Small-Cell Lung	Collectively, the knockdown of exosomal circ_0000519 repressed the cell growth and metastasis in NSCLC through the miR-1258/RHOV axis, which provided a new insight into NSCLC development and treatment.
lncRNA target	35581960	hsa-mir-143	Stomach Neoplasms	CONCLUSION: Our findings indicate that CASC20 serves as a tumor promoter by regulating metastasis in GC via the miR5p/MEMO1 axis.
genetics_knock down_promote	35581421	hsa-mir-30	prostate adenocarcinoma	3p inhibition blocked the functions of KDM5A knockdown in PRAD.
genetics_knock down_promote	35581180	hsa-mir-624	Carcinoma, Hepatocellular	Loss and gain of function experiments demonstrated that regulation of the expression of miR
lncRNA target	35581162	hsa-mir-10a	Pancreatitis	Circ_0000284 depletion could protect caerulein-induced AR42J cells from apoptosis and inflammation by upregulating miR-10a-5p expression and activating Wnt/beta-catenin pathway, underscoring a potential target for AP therapy.
epigenetics	35580699	hsa-let-7b	Carcinoma, Non-Small-Cell Lung	Additionally, KDM2B repressed the expression of microRNA (miR)-let-7b-5p through demethylation modification of H3K36me2, thereby promoting the expression of zester homolog 2 (EZH2), the target gene of let-7b-5p in NSCLC. In conclusion, KDM2B induces the EZH2/PKMYT1/Wnt/beta-catenin axis by inhibiting the let-7b-5p expression, which promotes NSCLC growth.
circRNA target	35580464	hsa-mir-142	Angelman Syndrome	CONCLUSIONS: Circ_0,003,423 protected HUVECs from ox-LDL-induced dysfunction by sponging miR3p and activating SIRT3/SOD2 signaling, which provided new potential targets for AS intervention and treatment.
genetics_overexpression_promote	35579981	hsa-mir-144	Thyroid Neoplasms	3p reduced proliferation, migration, invasion, and EMT of FRO and KTC3 cells, which was nullified by overexpressing E2F2 or TNIK expression.
other	35579934	hsa-mir-125b	Tuberculosis	In summary, negative pressure treatment after MTB infection can promote the polarization of macrophages to the proinflammatory M1 phenotype by regulating the XIST/miR-125b-5p/A20/NF-kappaB axis.
genetics_overexpression_promote	35579835	hsa-mir-624	Carcinoma, Hepatocellular	Circ_0006404 sponged miR-624 in HCC cell, and the overexpression of circ_0006404 suppressed miR-624 expression in HCC cell.
genetics_knock down_promote	35579772	hsa-mir-24	Multiple Myeloma	5p suppressed the malignant behaviors of MM cells, which were largely counteracted by the overexpression of HGF in MM cells.
other	35579738	hsa-mir-515	Osteosarcoma	5p-SLC7A11 axis in OS cell proliferation and metastasis, which is important in OS monitoring and treatment.
other	35579419	hsa-mir-34a	Carcinoma	This study is aimed to produce and utilize a new biologic miR-34a-5p (or miR-34a) molecule, namely, hBERA/miR-34a, to delineate the role of miR-34a-5p in the regulation of mitochondrial functions in human carcinoma cells. These results demonstrate the presence and involvement of the miR-34a-5p-MPV17L2 pathway in the control of mitochondrial functions in human carcinoma cells and support the utility of novel bioengineered miRNA molecules for functional studies.
lncRNA target	35579419	hsa-mir-34a	Lung Neoplasms	hEBRA/miR-34a was processed to target miR-34a-5p in human osteosarcoma and lung cancer cells, as determined by selective stem-loop reverse transcription quantitative polymerase chain reaction analysis.
lncRNA target	35579419	hsa-mir-34a	Osteosarcoma	hEBRA/miR-34a was processed to target miR-34a-5p in human osteosarcoma and lung cancer cells, as determined by selective stem-loop reverse transcription quantitative polymerase chain reaction analysis.
target gene	35579168	hsa-mir-802	Esophageal Neoplasms	Long Non-coding RNA SNHG16 Facilitates Esophageal Cancer Cell Proliferation and Self-renewal through the microRNA-802/PTCH1 Axis.
genetics_knock down_promote	35579106	hsa-mir-145	Acute Lung Injury	In contrast, loss of miR
genetics_knock down_promote	35579082	hsa-mir-33a	Lymphoma, B-Cell	Knockdown of circPCBP2 or miR-33a/b overexpression inhibited the stemness of DLBCL cells and promoted cancer cell apoptosis upon CHOP treatment.
other	35579073	hsa-mir-200c	Myocardial Reperfusion Injury	In this study, we investigated the effect of ozone on miR-200c expression and the potential role of miR-200c in an I/R myocardial injury model.
lncRNA target	35579073	hsa-mir-200	Myocardial Reperfusion Injury	Cell death detected by LDH release and apoptosis assay in the I/R model could also be inhibited by miR-200c inhibitor or ozone treatment.
other	35578792	hsa-mir-143	Infertility, Female	Our study highlights a functional micro-regulatory network composed of deubiquitinase (USP9X), small noncoding RNA (miR-143) and the TGF-beta signaling pathway, which plays a crucial role in the regulation of GC apoptosis and female fertility.
other	35578599	hsa-mir-98	Stomach Neoplasms	PITPNA-AS1/miR-98-5p to Mediate the Cisplatin Resistance of Gastric Cancer.
other	35578440	hsa-mir-515	Atherosclerosis	CONCLUSIONS: HOXA11-AS contributed to atherosclerotic injuries by directly regulating the miR5p/ROCK1 axis.
genetics_knock down_promote	35578338	hsa-mir-494	Esophageal Squamous Cell Carcinoma	Furthermore, silencing HDAC3 or overexpressing miR-494 was demonstrated to suppress aggressive phenotypes of ESCC cells both in vitro through the activated TGFbeta signaling pathway and in vivo, while TGIF1 overexpression induced opposite results.
genetics_GWAS	35578240	hsa-mir-129	Carcinoma, Hepatocellular	CONCLUSIONS: This study provides detailed insights into the regulatory network of the tumor-suppressive, epigenetically regulated miR
other	35578189	hsa-mir-379	gastric adenocarcinoma	3p).
other	35578189	hsa-mir-2681	gastric adenocarcinoma	3p).
other	35578189	hsa-mir-6807	gastric adenocarcinoma	3p).
other	35578189	hsa-mir-6499	gastric adenocarcinoma	3p).
circulation_biomarker_diagnosis_ns	35578107	hsa-mir-340	Diabetes, Gestational	3p in peripheral blood mononuclear cells (PBMCs) obtained from patients with GDM (n = 42) and healthy controls (n = 34) were evaluated, together with their correlation to the clinical parameters of participants and their newborns.
lncRNA target	35578071	hsa-mir-184	Adenocarcinoma of Lung	CONCLUSION: MiR-184 repressed LUAD cell processes via mediating C1QTNF6.
circRNA target	35577924	hsa-mir-19b	beta-Thalassemia	In conclusion, a novel hsa-circRNA-100466miR-19b-3pSOX6 pathway was identified, providing insight into HbF induction and suggesting targets beta-thalassemia treatment.
other	35577881	hsa-mir-124	Brain Neoplasms	Expression analysis of TPD52, KLF14, miR-124, and PKCepsilon provided useful information on the differences existing between the normal brain and SOL, in addition to gliomas; thus, might prove to be useful having diagnostic or prognostic value.
exosome	35577544	hsa-mir-455	Myocardial Reperfusion Injury	CONCLUSION: miR3p, shuttled by exosomes from MSCs, targets the MEKK1-MKK4-JNK signaling pathway to guard against myocardial ischemia-reperfusion damage.
other	35577542	hsa-mir-181a	Ischemic Stroke	3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene.
other	35577542	hsa-mir-16	Ischemic Stroke	3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene.
other	35577542	hsa-mir-124	Ischemic Stroke	3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene.
genetics_knock down_promote	35576990	hsa-mir-148b	Diabetic Nephropathies	Gain- and loss-of-function experiments were performed to verify the effects of miR-148b-3p on oxygen-glucose deprivation (OGD)-induced BMEC apoptosis and mitochondrial dysfunction. Mechanistically, circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction.
genetics_knock down_promote	35576990	hsa-mir-148b	Ischemic Stroke	Gain- and loss-of-function experiments were performed to verify the effects of miR-148b-3p on oxygen-glucose deprivation (OGD)-induced BMEC apoptosis and mitochondrial dysfunction. Mechanistically, circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction.
epigenetics	35576907	hsa-mir-148b	Acute Kidney Injury	circHIPK3 upregulated DNMT1/3a expression by competitively binding to miR-148b-3p, thus elevating the methylation level of Klotho promoter and accelerating SAKI cell senescence.
other	35576835	hsa-mir-6884	Esophageal Squamous Cell Carcinoma	In summary, our study elucidated that E2F1-activated LINC01224 regulated miR5p/DVL3 to actuate the Wnt/beta-catenin signaling pathway, which facilitates multiple phenotype of ESCC cells, including proliferation, migration, and invasion.
genetics_overexpression_promote	35576499	hsa-mir-424	Squamous Cell Carcinoma of Head and Neck	5p overexpression on the process of OSCC cells.
circRNA target	35576496	hsa-mir-143	Osteosarcoma	CONCLUSION: The regulation of malignant behaviors such as proliferation, invasion, migration, and multidrug resistance of OS cells by hsa_circ_0001982 may be achieved by targeting miR-143.
other	35576078	hsa-mir-146b	Schistosomiasis mansoni	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
other	35576078	hsa-mir-223	Liver Diseases	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
other	35576078	hsa-mir-146b	Liver Diseases	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
other	35576078	hsa-mir-146b	Schistosomiasis	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
other	35576078	hsa-mir-223	Schistosomiasis	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
other	35576078	hsa-mir-223	Schistosomiasis mansoni	We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni.
circRNA target	35575762	hsa-mir-25	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our results indicate that has_circ_0069313 induces OSCC immunity escape via the miR3p-Foxp3 axis in both OSCC cells and Treg cells.
genetics_GWAS	35575749	hsa-mir-1275	Colorectal Neoplasms	The current study results suggested that HAND2-AS1 gene rs2276941 polymorphism affecting the binding of hsa-miR-1275 was associated with CRC risk and might serve as a CRC susceptibility biomarker.
genetics_overexpression_promote	35575588	hsa-mir-29a	Osteosarcoma	Overexpressing miR-29a-3p aggravated apoptosis, dampened cell proliferation, colony formation, migration and invasion, and promoted autophagy of OS cells.
lncRNA target	35574307	hsa-mir-17	Colonic Neoplasms	Our study suggested that DNMBP-AS1 inhibited the progression of colon cancer through the miR5p/17-5p/NHLRC3 axis, which could be potential therapeutic targets for CC.
lncRNA target	35574307	hsa-mir-93	Colonic Neoplasms	Our study suggested that DNMBP-AS1 inhibited the progression of colon cancer through the miR5p/17-5p/NHLRC3 axis, which could be potential therapeutic targets for CC.
other	35574298	hsa-mir-29c	Carcinoma, Hepatocellular	The CRNDE/LINC00511/SNHG17/HCG18-miR-29c-3p axis was identified as the most likely ncRNA-associated pathway upstream of COMMD2 in LIHC.
lncRNA target	35573679	hsa-mir-21	Reperfusion Injury, Renal Ischemia	MiR-21 alleviated renal ischemia-reperfusion injury by inhibiting renal tubular epithelial cell apoptosis.
target gene	35572884	hsa-mir-223	Myocarditis	MiR-223-3p affects myocardial inflammation and apoptosis following myocardial infarction via targeting FBXW7.
circRNA target	35572733	hsa-mir-1283	Leukemia, Lymphocytic, Chronic, B-Cell	The functional roles of the circZNF91/miR-1283/WEE1 axis in CLL progression were examined by cell proliferation, apoptosis, and EdU incorporation assays. CONCLUSIONS: The circZNF91/miR-1283/WEE1 axis is engaged in the pathological phenotypes of CLL cells, which could serve as potential targets for future therapy development.
transcription factor target	35572727	hsa-mir-489	Neuroblastoma	Further studies showed that GPF treatment upregulated miR-489 in NBM cells via activating AMP-activated protein kinase (AMPK).
transcription factor target	35572723	hsa-mir-18a	Asthma	These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation.
transcription factor target	35572723	hsa-mir-498	Asthma	These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation.
transcription factor target	35572723	hsa-mir-99a	Asthma	These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation.
transcription factor target	35572197	hsa-mir-21	Glioma	Overall, we identified miR-21 as a potential target for CRISPR-based therapeutics in glioma.
other	35571741	hsa-mir-29c	Colonic Neoplasms	CONCLUSION: miR-488, miR-29c-3p, and GDF15 in colon cancer tissue are related to the clinicopathological features of patients in varying degrees and may become markers after early warning of colon cancer, which can provide effective guidance for clinical diagnosis and treatment.
transcription factor target	35571739	hsa-mir-124	Breast Neoplasms	3p/TNF-alpha/TRAF6-related pathway and inhibiting neuronal cell pyroptosis and subsequent inflammation.
transcription factor target	35571739	hsa-mir-124	Depression	3p/TNF-alpha/TRAF6-related pathway and inhibiting neuronal cell pyroptosis and subsequent inflammation.
genetics_overexpression_promote	35571651	hsa-mir-655	Pancreatic Carcinoma	Hypomethylation of promoter (P<0.01) and the regulation of hsa-miR-3655 may contribute to the overexpression of GABRP in pancreatic cancer.
genetics_overexpression_promote	35571488	hsa-mir-146b	Colonic Neoplasms	Overexpressed lncRNA LINC00893 Suppresses Progression of Colon Cancer by Binding with miR-146b-3p to Upregulate PRSS8.
other	35571440	hsa-mir-34a	Osteoarthritis	CONCLUSIONS: lncRNA MEG3 regulated the expression of FGF23, Bcl-2, Bax, TGF-beta1, Caspase 3, and Caspase 8 by regulating the miR-34a/Klotho axis, thereby affecting the progress of OA.
transcription factor target	35571376	hsa-mir-634	Squamous Cell Carcinoma of Head and Neck	mediated targeting of multiple cytoprotective process-related genes, including cellular inhibitor of apoptosis protein 1 (cIAP1), can effectively increase cisplatin (CDDP)-induced cytotoxicity and overcome CDDP resistance in OSCC cells.
other	35571371	hsa-mir-9	Brain Ischemia	5p.
other	35571371	hsa-mir-143	Brain Ischemia	5p.
other	35571371	hsa-mir-124	Brain Ischemia	3p were closely correlated with the evolution of ischemic brain injury, as their expression increased at 0.5 days after the onset of ischemia, peaked at day 1 or 3, and returned to normal levels at day 7 and 14.
other	35571371	hsa-mir-93	Brain Ischemia	5p.
other	35571371	hsa-mir-98	Brain Ischemia	5p.
circulation_biomarker_diagnosis_down	35571250	hsa-mir-122	Respiratory Distress Syndrome	In conclusion, adipose-derived circulating exosomal miR5p protects against ARDS by reinforcing pulmonary endothelial barrier through inhibition of EndMT and oxidative stress via down-regulation of the TGF-beta pathway, which propose a potential explanation for the obesity paradox in ARDS and indicate promising prospects for adipose-derived exosomes in cell-free therapies for ARDS.
circulation_biomarker_diagnosis_down	35571250	hsa-mir-122	Obesity	In conclusion, adipose-derived circulating exosomal miR5p protects against ARDS by reinforcing pulmonary endothelial barrier through inhibition of EndMT and oxidative stress via down-regulation of the TGF-beta pathway, which propose a potential explanation for the obesity paradox in ARDS and indicate promising prospects for adipose-derived exosomes in cell-free therapies for ARDS.
other	35571247	hsa-mir-3960	Brain Injuries, Traumatic	Further analyses revealed that circHtra1 functions as a miR-3960 sponge and increases the expression of GRB10, which is involved in NK cell infiltration after TBI.
other	35571241	hsa-mir-30	Pars Planitis	A rescue experiment further showed that circPTP4A2-miR5p-PDK2 signaling was critical to HuMSCs-SF-SIS in decreasing the fibrosis area and increasing the number of glands in the IUA model.
circulation_biomarker_diagnosis_down	35571237	hsa-mir-150	Pulmonary Disease, Chronic Obstructive	The plasma miR
circulation_biomarker_diagnosis_ns	35571214	hsa-mir-200c	psoriasis 1	Furthermore, NPM positively correlates with miR-200c circulating levels, which we previously showed to increase in Pso and correlate with CVD progression.
circulation_biomarker_diagnosis_ns	35571214	hsa-mir-200c	Cardiovascular Diseases	Furthermore, NPM positively correlates with miR-200c circulating levels, which we previously showed to increase in Pso and correlate with CVD progression.
other	35571119	hsa-mir-34a	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
other	35571119	hsa-mir-429	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
other	35571119	hsa-mir-31	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
other	35571119	hsa-mir-24	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
other	35571119	hsa-mir-449a	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
other	35571119	hsa-mir-491	Acute Pulmonary Embolism	5p, and miR-449a are downregulated.
lncRNA target	35571024	hsa-mir-25	Carcinoma, Non-Small-Cell Lung	Therefore, the LINC01128/miR3p/PTEN axis may promote EGFR-TKI resistance via the PI3K/Akt signaling pathway, which provides new insights into the underlying molecular mechanisms of drug resistance to EGFR-TKIs in NSCLC.
lncRNA target	35571014	hsa-mir-338	Esophageal Squamous Cell Carcinoma	Taken together, the circ-0007022/miR3p/NRP1 axis enhances the radiation resistance of ESCC cells via regulating EMT and PI3K/Akt pathway.
circulation_biomarker_diagnosis_up	35570854	hsa-mir-193a	Sarcoma, Kaposi	Subjects with latent KS infection had a differential upregulation of circulating miR-193a compared to HIV-positive, KS-negative subjects for whom circulating HHV-8 DNA was not detected.
genetics_GWAS	35570745	hsa-mir-1206	Adenocarcinoma of Lung	Furthermore, the inhibitory effects of circ_0129047 or BMPR2 overexpression on the malignant phenotype of LAC cells could be reversed by the overexpression of miR-1206.
other	35570481	hsa-mir-370	Wounds and Injuries	CONCLUSION: All results revealed that circ_0124644 accelerated endothelial injury in ox-LDL-treated HUVECs by mediating miR3p-related FOXO4 expression.
other	35570299	hsa-mir-211	Diabetic Retinopathy	CONCLUSION: MCM3AP-AS1 is downregulated in DR and promotes cell apoptosis by regulating miR-211/SIRT1.
other	35570080	hsa-mir-4523	Obesity	Furthermore, in silico analysis revealed generation of new miRNA (hsa-miR-4523) binding site and change in mRNA structure/stability which needs to be further investigated for possible role in altering TLR-2 gene regulation/expression in obesity.
genetics_knock down_suppress	35569812	hsa-mir-1322	Carcinoma, Hepatocellular	Circ_0000291 knockdown-mediated anti-tumor impacts in HCC cells were largely overturned by the interference of miR-1322.
genetics_knock down_promote	35569717	hsa-mir-338	Carcinoma, Renal Cell	3p RNA overexpression repressed the malignant phenotypes of RCC cells, while NUCB2 protein elevation could abrogate the effect.
lncRNA target	35569696	hsa-mir-1290	Ovarian Neoplasms	Notably, miR-1246 and miR-1290 shuttled in malignant ascites-derived EVs were identified to promote the invasion and migration of ovarian cancer cells through regulating a common target RORalpha.
lncRNA target	35569696	hsa-mir-1246	Ovarian Neoplasms	Notably, miR-1246 and miR-1290 shuttled in malignant ascites-derived EVs were identified to promote the invasion and migration of ovarian cancer cells through regulating a common target RORalpha.
lncRNA target	35568971	hsa-mir-618	Tuberculosis, Pulmonary	NORAD is a potential diagnostic biomarker for PTB and is involved in Mtb-infected macrophage activity and inflammation by targeting miR-618.
lncRNA target	35568918	hsa-mir-144	Lung Neoplasms	3p may function as a potential therapeutic target in lung cancer treatment in the future.
genetics_knock down_promote	35568813	hsa-mir-214	Osteoporosis	5p knockdown suppressed osteoclast differentiation and prevented bone loss.
other	35568745	hsa-mir-34a	Triple Negative Breast Neoplasms	In this regard, tsEV could be considered a proper vehicle for miR-34a replacement therapy and could exacerbate its anti-cancer effects in triple-negative breast cancer.
exosome	35568721	hsa-mir-27a	Glioblastoma	We demonstrated that EV-derived hsa-miR-27a-3p may promote M2 macrophage polarization to induce GBM.
lncRNA target	35567907	hsa-mir-503	Colorectal Neoplasms	5p downregulation suppressed in vitro CRC progression via promoting SALL1 expression.
lncRNA target	35567714	hsa-mir-503	Colorectal Neoplasms	5p/KANK1 axis has critical role in the progression of colorectal cancer, providing an effective prognostic indicator and promising target in treatment of colorectal cancer.
lncRNA target	35567596	hsa-mir-1200	Urinary Bladder Neoplasms	This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades.
genetics_overexpression_suppress	35567340	hsa-mir-622	Esophageal Squamous Cell Carcinoma	The inhibitory effects of miR-622 enrichment on EC cell proliferation, migration, EMT and glutamine metabolism were recovered by SLC1A5 overexpression. CONCLUSION: Circ_0001273 high expression contributed to EC progression via modulating the miR-622/SLC1A5 signaling axis.
other	35566730	hsa-mir-143	Intestinal Neoplasms	The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors.
other	35566730	hsa-mir-145	Intestinal Neoplasms	The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors.
other	35566730	hsa-mir-145	Colorectal Neoplasms	The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors.
other	35566730	hsa-mir-143	Colorectal Neoplasms	The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors.
circulation_biomarker_prognosis_ns	35566526	hsa-mir-21	Colorectal Neoplasms	This study investigated the expressions of plasma/exosomal microRNA-21 (miR-21) in 113 CRC patients by qPCR, their values of predicting CRC recurrence, and the possibility to improve the prognostic efficacy in early CRC recurrence in stratified patients by combined biomarkers including circulating miR-21s, circulating tumour cells/microemboli (CTCs/CTM), and serum carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9). However, stage IV patients stratified by a high level of exosomal miR-21 and stage I to III patients stratified by a high level of plasma miR-21 displayed significantly worse survival outcomes in predicting CRC recurrence, suggesting their different values to predict CRC recurrence in stratified patients.
genetics_overexpression_promote	35565830	hsa-mir-222	Muscular Atrophy	In C2C12 myotubes, both dexamethasone and miR-222 overexpression promoted muscle atrophy, however, this function was significantly reduced after genistein treatment.
other	35565434	hsa-mir-155	Lymphoma, B-Cell	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-155	Lymphoma	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-19a	Lymphoma, B-Cell	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-20a	Lymphoma, B-Cell	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-21	Lymphoma	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-21	Lymphoma, B-Cell	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-92a	Lymphoma, B-Cell	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-92a	Lymphoma	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-19a	Lymphoma	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
other	35565434	hsa-mir-20a	Lymphoma	We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma.
target gene	35565270	hsa-mir-1305	Ovarian Neoplasms	Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I.
other	35565239	hsa-mir-195	Colorectal Neoplasms	Conclusion: MiR-195 has strong value in predicting time to recurrence in CRC patients.
circulation_biomarker_diagnosis_ns	35563859	hsa-mir-150	Multiple Sclerosis	This study identifies miR5p and let-7b-5p packaged in blood myeloid EVs as possible biomarkers for cognitive deficits in MS.
circulation_biomarker_diagnosis_ns	35563859	hsa-let-7b	Multiple Sclerosis	This study identifies miR5p and let-7b-5p packaged in blood myeloid EVs as possible biomarkers for cognitive deficits in MS.
lncRNA target	35563834	hsa-mir-143a	Carcinoma, Hepatocellular	The LINC00152-miR-143a-3p-KLC2 axis may represent a therapeutic target in human HCC.
circulation_biomarker_diagnosis_ns	35563810	hsa-mir-126	Inflammation	In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	35563810	hsa-mir-146a	Inflammation	In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	35563810	hsa-mir-181a	Inflammation	In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	35563810	hsa-mir-21	Inflammation	In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR
other	35563647	hsa-mir-185	Fatigue	The findings herein point to a promising protein biomarker, phosphoglycerate kinase 1 (PGK1), that was associated with fatigue and displayed changes in abundance in saliva, and we suggest a possible biological mechanism whereby the expression of the PGK1 gene is regulated by miR3185 in response to fatigue.
transcription factor target	35563621	hsa-mir-122	non-alcoholic steatohepatitis	Our results suggest that the activation of glycolysis in Kupffer cells during NASH was partially induced by the upregulation of PKM2 via miR5p suppression.
lncRNA target	35563522	hsa-mir-449a	Triple Negative Breast Neoplasms	The induced expression of microRNA-449a elevated CIN beyond tolerable levels and induced apoptosis in TNBC cell lines by two different mechanisms: (I) promoting chromatid mis-segregation by targeting endonuclease EME1 and (II) inhibiting HDR by downregulating key players of the HDR network such as E2F3, BIRC5, BRCA2 and RAD51.
other	35563501	hsa-mir-669a	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-148a	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-1274a	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-377	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-199a	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-690	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
other	35563501	hsa-mir-9	Periodontitis	Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis.
lncRNA target	35563442	hsa-mir-205	Colonic Neoplasms	An inhibitor of miR-205 could recover Bcl2 expression and promoted the survival of CC cells upon DET treatment.
tissue_expression_ns	35563413	hsa-mir-20a	Hypercholesterolemia	In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture.
tissue_expression_ns	35563413	hsa-mir-106a	Hypercholesterolemia	In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture.
tissue_expression_ns	35563413	hsa-mir-17	Hypercholesterolemia	In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture.
other	35563410	hsa-mir-27b	Leukemia	The results showed that the level of selected miRNAs correlates with the level of proteins, especially p27, Bak1, NFkappaB, and CYP24A1, and miR-27b and miR-125b could be responsible for the anticancer activity of active forms of vitamin D(3) in human leukemia and lymphoma.
other	35563410	hsa-mir-125b	Leukemia	The results showed that the level of selected miRNAs correlates with the level of proteins, especially p27, Bak1, NFkappaB, and CYP24A1, and miR-27b and miR-125b could be responsible for the anticancer activity of active forms of vitamin D(3) in human leukemia and lymphoma.
genetics_overexpression_promote	35563301	hsa-mir-155	Cholangitis, Sclerosing, Primary	In contrast, the absence of miR-155 overexpression in the sigmoid colon of PSC-UC patients activated the Il-6/S1PR1 signalling pathway and imbalanced the IL17/FOXP3 ratio, which reinforces chronic colitis.
other	35563269	hsa-mir-196b	Adenocarcinoma, Sebaceous, Ocular	At least two miRNAs, miR-196b-5p (p 0.05) and miR-107 (p 0.001), displayed a statistically significant differential expression between OSCs and SCCCs with miR-196b-5p upregulated in SCCCs and miR-107 upregulated in OSCs. In conclusion, the combined testing of miR-196b-5p and miR-107, can be of additional use in routine diagnostics to discriminate OSCs from SCCCs.
other	35563269	hsa-mir-107	Adenocarcinoma, Sebaceous, Ocular	At least two miRNAs, miR-196b-5p (p 0.05) and miR-107 (p 0.001), displayed a statistically significant differential expression between OSCs and SCCCs with miR-196b-5p upregulated in SCCCs and miR-107 upregulated in OSCs. In conclusion, the combined testing of miR-196b-5p and miR-107, can be of additional use in routine diagnostics to discriminate OSCs from SCCCs.
other	35563178	hsa-mir-5100	Stomach Neoplasms	The effect and regulatory mechanism of DEK on autophagy and apoptosis in gastric cancer (GC), and the role between miR-5100 and DEK or miR-5100 and LEF1-AS1 are still unclear. In conclusion, our results found that LEF1-AS1 and miR-5100 sponge function, and the miR-5100/DEK/AMPK/mTOR axis regulates autophagy and apoptosis in gastric cancer cells.
exosome	35563123	hsa-mir-221	Aortic Aneurysm, Thoracic	TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222.
exosome	35563123	hsa-mir-146a	Aortic Aneurysm, Thoracic	TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222.
exosome	35563123	hsa-mir-222	Aortic Aneurysm, Thoracic	TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222.
other	35563053	hsa-mir-125b-1	endometriosis in scar of skin	3p are consistent with the benign nature of SE.
other	35563053	hsa-mir-1	endometriosis in scar of skin	3p are consistent with the benign nature of SE.
lncRNA target	35563023	hsa-mir-29b	Hand, Foot and Mouth Disease	We further predicted that novel_circ_0002006 might act as a molecular sponge for miR3p through the IFN-I pathway to inhibit CVB5 replication, and that novel_circ_0001066 might act as a molecular sponge for miR-29b-3p via the NF-kappaB pathway and for the inhibition of CVB5 replication.
lncRNA target	35563023	hsa-mir-152	Hand, Foot and Mouth Disease	We further predicted that novel_circ_0002006 might act as a molecular sponge for miR3p through the IFN-I pathway to inhibit CVB5 replication, and that novel_circ_0001066 might act as a molecular sponge for miR-29b-3p via the NF-kappaB pathway and for the inhibition of CVB5 replication.
other	35562921	hsa-mir-19a	Ischemic Stroke	Patients with moderate stroke had significantly elevated miR-19a-3p expression levels compared to patients with minor stroke at the first day of IS.
genetics_overexpression_promote	35562411	hsa-mir-148a	Nasopharyngeal Carcinoma	Silencing of SRGN and CREB1, as well as miR-148a-5p overexpression, repressed NPC tumor progression in vitro and in vivo.
other	35562351	hsa-mir-17	Alzheimer Disease	TARBP2/SNHG7/miR5p/NFATC3 pathway implied a potential mechanism in studies of BBB changes in AD pathological progression.
lncRNA target	35562348	hsa-mir-147a	Prostatic Neoplasms	Collectively, RP1-59D14.5 promoted yes-associated protein (YAP) degradation to activate the Hippo pathway in PCa progression via targeting the miR-147a/LATS1/2 axis and recruiting HUR to promote the interaction of CK1 and -transducin repeat-containing protein (TrCP).
lncRNA target	35562342	hsa-mir-378a	Carcinoma, Renal Cell	Our results support that the DMDRMR/miR-378a-5p/DAB2IP axis may serve as a novel target for combination diagnosis or therapy of ccRCC patients.
lncRNA target	35562181	hsa-mir-221	Thyroid Neoplasms	We have identified a likely operative post-transcriptional regulatory network in which the downregulated lncRNA, SPTY2D1-AS1, is predicted to target the most abundant and upregulated miRNAs in thyroid cancer, particularly miR-221, a well-known oncomiRNA in cancer. Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221.
circulation_biomarker_diagnosis_ns	35561893	hsa-mir-532	Multiple Myeloma	RESULTS: MM serum increased the expressions of TF and miR-532, induced thrombin generation, inhibited EPCR and protein C activation in HUVECs. And metformin could reverse the effects of MM serum on the expressions of TF, EPCR and miR-532, thrombin generation, protein C activation in HUVECs.
genetics_GWAS	35561450	hsa-mir-4423	Multiple Sclerosis	On the other hand, the MS risk allele A of SNP rs817478, which substitutes the first C in a CNNC sequence motif, was found to cause a markedly lower efficiency in the processing of hsa-mir-4423.
other	35561231	hsa-mir-503	Obesity	miR-130a (pro-angiogenic) was approximately 1.4-fold (P = 0.011) and miR-503 (anti-angiogenic) approximately 1.8-fold (P = 0.017) greater in OB compared with LN subjects at all time points.
other	35560511	hsa-let-7c	Lung Diseases	Collectively, CuE protected against nicotine-induced airway remodelling and partially depended on the induction of let-7c-5p; our future work would pay more attention to other downstream effectors of the miR to promote the treatment of nicotine-induced pulmonary disorders.
lncRNA target	35560511	hsa-let-7c	Tobacco Use Disorder	Changes in viability, inflammation and let-7c-5p/NGF pathway in nicotine-treated bronchial epithelial cells (BECs) were detected under CuE treatment (5 muM).
genetics_GWAS	35560017	hsa-let-7b	Endometriosis	CONCLUSION(S): We identified differential Let-7b methylation in endometriosis, demonstrating that the epigenetic nature of the disease extends to the regulation of miRNAs.
other	35559743	hsa-mir-23b	Uterine Hemorrhage	CONCLUSION(S): Reduced expression of the miR-23b-3p/24-3p/27b-3p cluster is associated with elevated expression of CXCL12, which may contribute to the pathophysiology of AUB.
other	35559420	hsa-mir-671	Breast Neoplasms	YY1 as a promoter regulating the circ_0001946/miR-671-5p/EGFR axis to promote chemotherapy resistance in breast cancer cells.
target gene	35559394	hsa-mir-107	Breast Neoplasms	LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway.
lncRNA target	35559382	hsa-mir-122	Liver Cirrhosis	CONCLUSION: Circ_MTM1 could serve as a promoter in HBV-related LF through miR
lncRNA target	35559382	hsa-mir-122	Hepatitis B, Chronic	CONCLUSION: Circ_MTM1 could serve as a promoter in HBV-related LF through miR
other	35559021	hsa-mir-199a	Pleomorphic Sarcoma, Undifferentiated	After verification, the relative expressions of hsa-miR-199a-3p and hsa-miR-34a-5p were increased and decreased in the UPS tumor tissue compared with those in the adjacent normal tissue, respectively. Conclusion: NF1 and NF1-related microRNAs including hsa-miR-199a-3p and hsa-miR-34a-5p may be novel biomarkers in the diagnosis of undifferentiated pleomorphic sarcoma (UPS).
other	35559021	hsa-mir-34a	Pleomorphic Sarcoma, Undifferentiated	After verification, the relative expressions of hsa-miR-199a-3p and hsa-miR-34a-5p were increased and decreased in the UPS tumor tissue compared with those in the adjacent normal tissue, respectively. Conclusion: NF1 and NF1-related microRNAs including hsa-miR-199a-3p and hsa-miR-34a-5p may be novel biomarkers in the diagnosis of undifferentiated pleomorphic sarcoma (UPS).
therapeutic target	35558599	hsa-mir-4516	Stomach Neoplasms	A microRNA-4516 inhibitor sensitizes chemo-resistant gastric cancer cells to chemotherapy by upregulating ING4.
lncRNA target	35558291	hsa-mir-873	Granulomatosis with Polyangiitis	5p inhibitor activated the p38/Nrf2/HO-1 signaling pathway in KGN cells.
lncRNA target	35558291	hsa-mir-873	Polycystic Ovary Syndrome	The findings may provide insightful evidence for preventing and treating PCOS by targeting miR
lncRNA target	35558099	hsa-mir-125b	Growth Hormone-Secreting Pituitary Adenoma	Interestingly, microRNA (miR)-125b, which is one of the most abundantly expressed small RNAs in U-exo, was found to suppress IFV replication possibly via the induction of IFN-stimulated genes (ISGs).
other	35558077	hsa-mir-10b	nonpapillary renal cell carcinoma	Finally, we predicted a key SNHG3/AL513497.1-miR-10b-5p-TRPV3 axis linking to carcinogenesis and progression of ccRCC.
exosome	35557942	hsa-mir-122	Rectal Injury	Hypoxic EV-derived miR5p plays a critical pathologic role in radiation-induced rectal injury and may be a potential therapeutic target.
target gene	35557905	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	LncRNA CASC2 inhibits autophagy and promotes apoptosis in non-small cell lung cancer cells via regulating the miR-214/TRIM16 axis.
genetics_overexpression_suppress	35557748	hsa-mir-217	Fibrosis, Renal	Overexpressed ZEB1-AS1 may inhibit renal fibrosis in diabetic nephropathy by regulating the miR-217/MAFB axis, identifying novel therapeutic targets for renal fibrosis in diabetic nephropathy.
genetics_overexpression_suppress	35557748	hsa-mir-217	Diabetic Nephropathies	Overexpressed ZEB1-AS1 may inhibit renal fibrosis in diabetic nephropathy by regulating the miR-217/MAFB axis, identifying novel therapeutic targets for renal fibrosis in diabetic nephropathy.
exosome	35557596	hsa-mir-142	Carcinoma, Hepatocellular	Exosomal miR-142-3p secreted by hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) cells promotes ferroptosis of M1-type macrophages through SLC3A2 and the mechanism of HCC progression.
circulation_biomarker_diagnosis_ns	35557515	hsa-mir-21	limb ischemia	In patients with limb ischemia, the high expression of circulating miR-21 was associated with less subsequent MALE. Additionally, abolishing miR-21 impairs angiogenesis and promotes apoptosis post limb ischemia.
circulation_biomarker_diagnosis_ns	35557032	hsa-mir-34a	Carcinoma, Ovarian Epithelial	The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively.
circulation_biomarker_diagnosis_ns	35557032	hsa-let-7f	Carcinoma, Ovarian Epithelial	The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively.
circulation_biomarker_diagnosis_ns	35557032	hsa-mir-1	Carcinoma, Ovarian Epithelial	The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively.
lncRNA target	35554780	hsa-mir-26a	Osteoporosis, Diabetic	In a word, USCs-EVs-miR-26a-5p is a promising therapy for DOP by activating HIF-1alpha/VEGFA pathway through HDAC4 inhibition.
other	35553409	hsa-mir-6884	Ovarian Neoplasms	In summary, our research verified the PART1/miR5p/RACGAP1/RRM2 axis in OC cells, which signified that PART1 might act as a novel biomarker in OC.
circulation_biomarker_diagnosis_up	35553331	hsa-mir-34a	Coronary Artery Disease	However, the expression of miR-34a, miR-149 in the plasma of CAD patients was not significantly different with the control group.
circulation_biomarker_diagnosis_up	35553331	hsa-mir-149	Coronary Artery Disease	However, the expression of miR-34a, miR-149 in the plasma of CAD patients was not significantly different with the control group.
other	35553329	hsa-let-7a	nephrotic syndrome type 1	The differential expression of microRNA let-7a is useful to discriminate SSNS and SRNS.
other	35552758	hsa-mir-4486	Endometrial Hyperplasia	To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways.
other	35552758	hsa-mir-4486	Polycystic Ovary Syndrome	To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways.
other	35552758	hsa-mir-223	Endometrial Hyperplasia	To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways.
other	35552758	hsa-mir-223	Polycystic Ovary Syndrome	To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways.
other	35552175	hsa-mir-204	Hypertension, Pulmonary	RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion.
other	35552175	hsa-mir-223	Hypertension, Pulmonary	RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion.
other	35552175	hsa-mir-210	Hypertension, Pulmonary	RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion.
other	35552172	hsa-mir-423	Heart Failure	5p was implicated in left ventricular hypertrophy and might be a potential biomarker for assessing the therapeutic effect of cardiac rehabilitation on hypertensive patients with heart failure with a moderately reduced ejection fraction.
other	35552172	hsa-mir-423	Hypertension	5p was implicated in left ventricular hypertrophy and might be a potential biomarker for assessing the therapeutic effect of cardiac rehabilitation on hypertensive patients with heart failure with a moderately reduced ejection fraction.
other	35552087	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	5p/HMGA2 axis.
lncRNA target	35551606	hsa-mir-144	Breast Neoplasms	CONCLUSION: LINC00662 enhances cell proliferation, migration, invasion and stemness in BC by targeting miR
lncRNA target	35551487	hsa-mir-155	Inflammation	Based on the specific patterns of expression in gastritis and cancer, CD9, MST1R, and ADAM10 were candidates for the most probable targets of miR
transcription factor target	35551348	hsa-mir-146a	Fibrosis, Renal	5p may play an inhibitory role.
transcription factor target	35551348	hsa-mir-148a	Fibrosis, Renal	5p may play an inhibitory role.
transcription factor target	35551348	hsa-mir-362	Fibrosis, Renal	5p may play an inhibitory role.
transcription factor target	35551348	hsa-mir-122	Fibrosis, Renal	5p may play an inhibitory role.
transcription factor target	35551348	hsa-mir-130a	Fibrosis, Renal	5p may play an inhibitory role.
lncRNA target	35550840	hsa-mir-223	Parkinson Disease	Overall, DLX6-AS1 promotes the microglial inflammatory response in PD through the ceRNA mechanism of miR3p/NRP1.
other	35550634	hsa-mir-126	Diabetes Mellitus, Type 1	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
other	35550634	hsa-mir-29b	Diabetes Mellitus, Type 1	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
other	35550634	hsa-mir-155	Diabetes Mellitus, Type 1	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
other	35550634	hsa-mir-29b	Diabetic Nephropathies	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
other	35550634	hsa-mir-126	Diabetic Nephropathies	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
other	35550634	hsa-mir-155	Diabetic Nephropathies	METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, </= 2.5 years (SD, n = 25) or of long-duration, >/= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls.
circRNA target	35549985	hsa-mir-582	Adenocarcinoma of Lung	3p inhibitor decreased lung cancer cell proliferation and promoted apoptosis.
exosome	35549815	hsa-mir-21	Osteoporosis	Bone mesenchymal stem cells (BMSCs)-derived exosomes (Exos) play important roles in osteoporosis, while the regulation of microRNA (miR)5p remains unclear.
genetics_overexpression_promote	35549813	hsa-mir-661	Melanoma	miR-661 overexpression partially reversed hsa_circ_0103232 promoting effect on melanoma cells viability, proliferation, migration, invasion, and EMT (P < 0.01).
lncRNA target	35549806	hsa-mir-1290	Esophageal Neoplasms	Thus, circ_0086414 inhibited EC cell malignancy through the miR-1290/SPARCL1 pathway, providing a reliable target for the therapy of EC.
lncRNA target	35549803	hsa-mir-4306	Osteoarthritis	CONCLUSION: CircPDE4D and miR-4306 were important regulators in regulating IL-1beta-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction.
transcription factor target	35549788	hsa-mir-140	Arthritis, Rheumatoid	CONCLUSION: SP can alleviate RA by promoting the expression of miR
genetics_overexpression_promote	35549691	hsa-mir-107	Breast Neoplasms	Overexpression of miR-107 suppressed the expression of NEDD9, thereby inhibiting the invasion, migration and proliferation of BC cells, but interference with miR-107 promoted the expression of NEDD9 as well as invasion, migration and proliferation.
lncRNA target	35549643	hsa-mir-24	Ovarian Neoplasms	Hence, we demonstrate that miR3p suppressed ovarian cancer progression by targeting the WNK2/RAS pathway.
lncRNA target	35549631	hsa-mir-148b	Carcinoma, Non-Small-Cell Lung	In summary, circ_0120376 contributes to the malignancy of NSCLC cells through a ceRNA mechanism via regulating miR-148b-3p/CEP55 axis.
target gene	35549438	hsa-mir-626	Squamous Cell Carcinoma of Head and Neck	miR-626 Inhibition Enhanced the Radiosensitivity to Oral Squamous Cell Carcinoma via the Downregulation of Nuclear Factor Kappa-B Signaling.
transcription factor target	35548888	hsa-mir-26a	Osteoarthritis	CONCLUSION: Our study suggested that hypoxic USC-EVs may represent a promising strategy for osteoarthritis by promoting the proliferation and migration of chondrocytes via miR-26a-5p transfer.
exosome	35548775	hsa-mir-146a	Myocardial Infarction	Initially, we found that exosomes with low expression of miR-146a-5p derived from myocardial infarction tissues modulated macrophage polarization. Exosomal miR-146a-5p plays important roles in macrophages, illuminating a novel potential therapeutic target in myocardial infarction.
lncRNA target	35547763	hsa-mir-23a	Brain Ischemia	Conclusion: Our results demonstrated that M2 microglia could communicate to OPCs through M2-EVs and promote white matter repair via miR-23a-5p possibly by directly targeting Olig3 after ischemic stroke, suggesting M2-EVs is a novel and promising therapeutic strategy for white matter repair in stroke and demyelinating disease.
lncRNA target	35547289	hsa-mir-613	Squamous Cell Carcinoma of Head and Neck	SNAI2 axis on EMT and drug resistance in LSCC, providing new targets for LSCC diagnosis and treatment.
other	35547243	hsa-mir-495	Coronary Occlusion	The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients.
other	35547243	hsa-mir-494	Coronary Occlusion	The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients.
other	35547243	hsa-mir-29	Coronary Occlusion	The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients.
lncRNA target	35546848	hsa-mir-155	Breast Neoplasms	MicroRNA-155 regulates the expression of 147 target genes that are involved in cancer pathways, and its expression level has been shown to be up-regulated in breast cancer.
circRNA target	35546509	hsa-mir-195	Endometrial Neoplasms	5p, which could provide pivotal potential therapeutic targets for the treatment of EC.
lncRNA target	35545863	hsa-mir-143	Stomach Neoplasms	3p/IGF1R axis, suggesting that circ_0006089 may serve as a promising therapeutic target for GC.
genetics_knock down_promote	35545774	hsa-mir-155	Dermatitis, Atopic	The interaction among IL-32, JAK1 and miR-155 was identified with their roles in AD analyzed through loss- and gain-of-function assays.
circRNA target	35545766	hsa-mir-513a	Nasopharyngeal Carcinoma	CONCLUSION: Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of NPC cells via miR-513a-3p/PTEN axis, thereby suppressing the progression of NPC.
other	35545753	hsa-mir-155	Scleroderma, Systemic	5p are critical for SSc progression, which may provide novel insights into the pathogenesis of SSc.
genetics_overexpression_promote	35545731	hsa-mir-27a	Squamous Cell Carcinoma of Head and Neck	Smad4 was downregulated in LSCC tissues, and simultaneous overexpression of miR-27a and Smad4 resulted in reduced cell activity and tumorigenicity.
lncRNA target	35545654	hsa-mir-214	Glioma	Collectively, our research discovered the potential signaling mechanism associated with C3G-mediated suppression of TMZ resistance in LN-18/TR cells through miR
lncRNA target	35545535	hsa-mir-508	Diabetes, Gestational	Collectively, circ_FOXP1 promotes the growth and survival of HG-treated human trophoblast cells through the miR3p/SMAD2 pathway, hinting that circ_FOXP1 was involved in GDM progression.
lncRNA target	35545369	hsa-mir-23a	Colorectal Neoplasms	5p, can compete for endogenous RNA through direct interaction with miR-323a-3p and miR
lncRNA target	35545369	hsa-mir-532	Colorectal Neoplasms	5p, can compete for endogenous RNA through direct interaction with miR-323a-3p and miR
other	35545365	hsa-mir-1	Alopecia	CONCLUSIONS: HSP27 could combine with miR-1 to up-regulate AR levels, which is closely related to the development of AGA.
other	35545360	hsa-mir-16	Autoimmune polyendocrinopathy syndrome, type 1	CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats.
other	35545360	hsa-mir-16	Adenine phosphoribosyltransferase deficiency	CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats.
other	35545337	hsa-mir-450b	Colorectal Neoplasms	Real-time PCR results showed that the expression levels of hsa_circRNA_0065173, ADCY5, CHRM2, CNR1 and LPAR1 in the CRC tissues were significantly reduced compared with the adjacent normal tissues (all P<0.05); the expression levels of hsa-mir-450b and hsa-miR-582 were significantly increased (both P<0.05).
genetics_knock down_promote	35545336	hsa-mir-133b	Urinary Bladder Neoplasms	Both overexpression of miR-133b and knockdown of SOX4 significantly inhibited the proliferation, colony formation, and invasion capacity of bladder cancer cells in vitro.
lncRNA target	35545320	hsa-mir-223	Acute Lung Injury	Compared with the model group, the W/D value of lungs, lung injury score, and levels of inflammatory factors in bronchoalveolar lavage fluid were significantly decreased in the chlorogenic acid group, the chlorogenic acid+miR-223 NC group, and the chlorogenic acid+miR-223 antagomir group (all P<0.05); lung tissues damage was alleviated; the numbers of EOS, lymphocytes, and neutrophils in bronchoalveolar lavage fluid were significantly decreased (all P<0.05); the expression levels of miR-223 in lung tissues were significantly increased (P<0.05); and the expression levels of NLRP3 protein were significantly decreased (P<0.05).
genetics_overexpression_promote	35543855	hsa-mir-19a	Stomach Neoplasms	TCGA-based expression analysis and qRT-PCR assay illustrated that microRNA-19a-3p was overexpressed in gastric cancer.
other	35543802	hsa-mir-4685	Schizophrenia	3p/UBE2K axes have the greatest probability of being involved in the pathophysiology of SCZ.
other	35543802	hsa-mir-127	Schizophrenia	3p/UBE2K axes have the greatest probability of being involved in the pathophysiology of SCZ.
exosome	35543792	hsa-mir-556	Cardiomyopathies	CONCLUSION: Lnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury.
genetics_overexpression_suppress	35543644	hsa-mir-143	Cancer Pain	Overexpression of miR
circRNA target	35543435	hsa-mir-22	Lupus Erythematosus, Systemic	CONCLUSIONS: Collectively, circRACGAP1 regulated the AKT signalling pathway via binding to miR3p in the progression of SLE, suggesting therapeutic targets for SLE treatment.
lncRNA target	35543383	hsa-mir-139	Depression	5p inhibition plays an antidepressant-like role and might serve as an effective depression target (Fig.
lncRNA target	35543246	hsa-mir-1247	Carcinoma, Squamous Cell, Cutaneous	5p suppressed CSCC cell progression by inhibiting CSF3.
target gene	35542225	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Long non-coding RNA CASC2 enhanced cisplatin-induced viability inhibition of non-small cell lung cancer cells by regulating the PTEN/PI3K/Akt pathway through down-regulation of miR-18a and miR-21.
target gene	35542225	hsa-mir-18a	Carcinoma, Non-Small-Cell Lung	Long non-coding RNA CASC2 enhanced cisplatin-induced viability inhibition of non-small cell lung cancer cells by regulating the PTEN/PI3K/Akt pathway through down-regulation of miR-18a and miR-21.
lncRNA target	35542211	hsa-mir-155	Acute Kidney Injury	The present results suggest that miR-155 inhibitor could be used in an effective targeting strategy for the treatment of acute kidney injury (AKI).
genetics_knock down_promote	35541941	hsa-mir-449a	Stomach Neoplasms	Furthermore, in vitro knockdown of miR-449a by siRNA significantly inhibited MKN-28 cell proliferation, migration and invasion as well as tumorigenesis via inducing G0/G1 arrest of GC cells.
lncRNA target	35541917	hsa-mir-494	Carcinoma, Hepatocellular	Mechanistically, in p53-expressing hepatoma cells, Linc01612 acts as a competitive endogenous RNA and promotes the expression of activation transcription factor 3 (ATF3) by sponging microRNA-494 (miR-494), which in turn inhibits MDM2-mediated ubiquitination of p53 and activates the p53 pathway.
lncRNA target	35541914	hsa-mir-106b	Colorectal Neoplasms	Then, silencing LINC01559 restored the malignant phenotype of CRC cells, while cotransfection of miR-106b-5p inhibitor neutralized this effect. The results revealed a negative functional regulation of the LINC01559/miR-106b-5p/PTEN axis in CRC progression and explored a new mechanism of METTL3-mediated m6A modification on LINC01559.
other	35541892	hsa-mir-193a	Stomach Neoplasms	In conclusion, our results illustrated that palmitic acid/p-STAT3/miR-193a-3p/LAMC1 pathway promotes preadipocyte differentiation, pre-metastatic niche formation and gastric cancer cell colonization to peritoneum.
other	35541422	hsa-mir-16	hereditary diffuse gastric cancer	Herein, we report a multiplex detection platform based on a suspension array with aggregation-induced emission luminogen (AIEgen) barcodes for simultaneous quantitative measurement of let-7b-5p, miR5p and miR-19b-3p, which are associated with gastric cancer.
other	35541422	hsa-mir-19b	hereditary diffuse gastric cancer	Herein, we report a multiplex detection platform based on a suspension array with aggregation-induced emission luminogen (AIEgen) barcodes for simultaneous quantitative measurement of let-7b-5p, miR5p and miR-19b-3p, which are associated with gastric cancer.
other	35540851	hsa-mir-122	Myocardial Infarction	MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure.
lncRNA target	35540851	hsa-mir-122	Cardiovascular Diseases	MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure. We therefore believe that microRNA-122 and Sestrin-2 can be developed as potential therapeutic targets against apoptosis in cardiovascular diseases.
other	35540851	hsa-mir-122	Heart Failure	MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure.
other	35540477	hsa-mir-19b	late onset Parkinson's disease	Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD).
other	35540477	hsa-mir-19b	Parkinson Disease	Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD).
other	35540477	hsa-mir-19b	Nervous System Diseases	Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD).
other	35540218	hsa-mir-137	Spinal Cord Injuries	Thus, the objective of this study is to determine the role of miRNA (miR)3p during curcumin treatment after SCI.
other	35540209	hsa-mir-137	Colorectal Neoplasms	Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis.
lncRNA target	35539318	hsa-mir-34a	Triple Negative Breast Neoplasms	In the present study, nanodiamond (ND), protamine (PS) and folic acid (FA) were used to construct ND-based layer-by-layer nanohybrids through a self-assembly approach for targeted miR-34a delivery in TNBC cells and xenograft TNBC tumors.
transcription factor target	35538494	hsa-mir-3178	Pancreatic Carcinoma	These findings suggest that hsa-miR-3178 could be a novel therapeutic target for overcoming gemcitabine resistance in PC.
lncRNA target	35538293	hsa-mir-665	Ischemic Stroke	This paper aimed to explore the regulatory mechanism of DEX in ischemic stroke through miR-665/ROCK2 axis. DEX has a protective effect in ischemic stroke by promoting miR-665 expression to downregulate ROCK2/NF-B axis, suggesting DEX has a beneficial effect on ischemic stroke and miR-665 is a conceivable target for the therapeutics and diagnosis of ischemic stroke.
other	35538197	hsa-mir-218	Colorectal Neoplasms	5p/SKAP1 axis.
other	35538149	hsa-mir-6891	Sjogren's Syndrome	Moreover, the HLA-locus-expressed miRNA miR6891-5p was decreased in pSS MSCs. pSS MSCs show decreased levels of miR6891-5p, a HLA-expressed miRNA.
target gene	35538053	hsa-mir-494	T-cell acute lymphoblastic leukemia	CircFBXW7 inhibits the tumorigenesis of T-cell acute lymphoblastic leukemia through modulating miR-494-3p/SOX1 axis.
lncRNA target	35538030	hsa-mir-1207	Uterine Cervical Neoplasms	5p and inhibits miR
genetics_overexpression_promote	35538027	hsa-mir-545	Ovarian Neoplasms	Overexpression of PTP4A1 abrogates the inhibitory function of miR
transcription factor target	35537355	hsa-mir-223	Asthma	Taken together, our study suggests that miR3p is a regulator of allergic inflammation and could potentially be used to develop novel and targeted therapy for asthma.
lncRNA target	35537198	hsa-mir-1269	Colorectal Neoplasms	HOXC-AS3 directly interacted with miR-1269 in CRC cells. CONCLUSIONS: Upregulation of HOXC-AS3 inhibited TGF-beta2-induced colorectal cancer (CRC) cell migration and invasion possibly by sponging miR-1269.
other	35537095	hsa-mir-181a	Alzheimer Disease	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35537095	hsa-mir-146a	Alzheimer Disease	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35537095	hsa-mir-181a	Cognitive Dysfunction	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35537095	hsa-mir-146a	Cognitive Dysfunction	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35537095	hsa-mir-148a	Alzheimer Disease	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35537095	hsa-mir-148a	Cognitive Dysfunction	A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med.
other	35536760	hsa-mir-10b	Multiple Myeloma	Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM.
other	35536760	hsa-mir-192	Multiple Myeloma	Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM.
other	35536760	hsa-mir-492	Multiple Myeloma	Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM.
other	35536760	hsa-mir-24	Multiple Myeloma	Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM.
transcription factor target	35536531	hsa-mir-425	Arthritis, Rheumatoid	Overall, Tofacitinib exerted inhibitory effect on proliferation and inflammation of RA-FLS through modulating STAT6/miR
other	35536524	hsa-mir-17	Leukemia, Myeloid, Acute	CONCLUSIONS: High expression of miR-17 in de novo AML patients pointed to dismal clinical outcome and disease recurrence, which could serve as novel prognostic biomarker for AML patients.
genetics_knock down_promote	35536149	hsa-mir-16	Colorectal Neoplasms	5p overexpression or FOXK1 knockdown reduced CRC cell proliferation and angiogenesis of human umbilical vein endothelial cells co-cultured with the supernatant of CRC cells, whereas miR
genetics_overexpression_suppress	35536095	hsa-mir-30	Osteoarthritis	5p depletion and FSHR overexpression diminished the effects of silencing LINC00707 in OA progression.
other	35536066	hsa-mir-488	Venous Thrombosis	miR-488 combined with SIRT1 has a high predictive value for the occurrence of DVT.
other	35535987	hsa-mir-335	Multiple Myeloma	CircKCNQ5 controls proliferation, migration, invasion, apoptosis, and glycolysis of multiple myeloma cells by modulating miR-335-5p/BRD4 axis.
lncRNA target	35535903	hsa-mir-24	Brain Ischemia	3p reduces ischemic brain damage via the GATA2/A1R axis.
genetics_overexpression_promote	35535453	hsa-mir-367	Breast Neoplasms	Therefore, we aimed to investigate whether overexpression of miR-302/367 cluster and aspirin treatment cooperate in the induction of reprogramming and tumor suppression in breast cancer cells.
other	35535387	hsa-mir-577	Heart Valve Diseases	These phenomena may result from hsa_circ_0003748 promoting RVHD after sponging miR-577.
circRNA target	35535385	hsa-mir-1278	Stomach Neoplasms	MiR-1278 targeted FN1, and silencing FN1 neutralized the effects of miR-1278 inhibitors on GC progression.
genetics_GWAS	35535334	hsa-mir-146a	Environmental Illness	This is the first study reporting that miR146a rs57095329 A/G, rs2961920A/C, and rs6864584 T/C polymorphisms are associated with the risk of IRSM in a southern Iranian population.
lncRNA target	35534923	hsa-mir-3	Atherosclerosis	CONCLUSIONS: This study provides proof of principle for the application of pHLIP for treating advanced atherosclerosis via pharmacological inhibition of miR-33 in macrophages that avoid the deleterious effects in other metabolic tissues.
other	35534828	hsa-mir-20a	Diabetes Mellitus, Type 1	The ROC curves showed that ADM (0.9375), RRAGD (0.8958), and hsa-mir-320a (0.9417) had high accuracy in T1D diagnosis. CONCLUSION: The constructed regulatory networks, including miR-320a/ADM/SOX5 and miR-320a/RRAGD/SOX5, may provide new insight into the mechanisms of development and progression in T1D.
lncRNA target	35533989	hsa-mir-1249	Influenza, Human	5p played an important role in ALI, and further investigation of its target gene SLC4A1 and NF-kappaB signaling pathway provides ideas for new therapeutic targets and strategies for ALI.
lncRNA target	35533989	hsa-mir-1249	Acute Lung Injury	5p played an important role in ALI, and further investigation of its target gene SLC4A1 and NF-kappaB signaling pathway provides ideas for new therapeutic targets and strategies for ALI.
lncRNA target	35533615	hsa-mir-526b	Uterine Cervical Neoplasms	Hsa_circ_0001495/miR-526b-3p/TMBIM6 axis also regulated the phosphorylation of mammalian target of rapamycin (mTOR) in CC cells.
other	35533171	hsa-mir-145	Multiple Sclerosis	Therefore, an ultrasensitive optical biosensor based on hybridization chain reaction (HCR) was developed to detect microRNA-145 (miRNA-145) as an MS biomarker.
lncRNA target	35533015	hsa-mir-375	Fatty Liver	In this study, the differentially expressed miR-375 as well as its target gene MAP3K1 (mitogen-activated protein kinase kinase kinase 1) were screened out by interaction network analysis of microRNA sequencing results and transcriptome profiling in the fatty liver group of the F0-F3 generation (p < 0.05 or p < 0.01).
other	35532940	hsa-mir-122	Alzheimer Disease	5p were differentially expressed compared with CN or PD.
other	35532940	hsa-mir-210	Alzheimer Disease	5p were differentially expressed compared with CN or PD.
lncRNA target	35532870	hsa-mir-99a	Uterine Cervical Neoplasms	In addition, cellular experiments including CCK8, wound healing, Transwell and flow cytometry assays disclosed that transfection of miR-99a-5p mimic could suppress the cell activity, cell migratory, and invasive abilities, and promote cell apoptosis, thus inhibiting the tumor progression of CSCC cells.
other	35532548	hsa-mir-20a	Osteoporosis	ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures.
other	35532548	hsa-mir-23a	Osteoporosis	ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture.
other	35532548	hsa-mir-20a	Fractures, Bone	ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures.
other	35532548	hsa-mir-23a	Fractures, Bone	ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture.
lncRNA target	35532539	hsa-mir-375	Prostatic Neoplasms	miR-375 mimic could partially reverse the inhibitory effects of sh-BACH1 on the proliferation, invasion, and migration of isoflurane-treated PC cells.
circRNA target	35532376	hsa-mir-139	Ischemic Stroke	In summary, we reveal for the first time that circUSP36 attenuates ischemic stroke injury through the miR3p/SMAD3/Bcl2 signal axis, which make circUSP36 a potential therapeutic target for IS.
other	35532294	hsa-mir-27a	Carcinoma, Hepatocellular	The oncogenic miR-27a/BTG2 axis promotes obesity-associated hepatocellular carcinoma by mediating mitochondrial dysfunction.
circRNA target	35532261	hsa-mir-223	Stomach Neoplasms	Importantly, ICA inhibited GC cell viability and triggered GC cell pyroptosis by regulating the hsa_circ_0003159/miR
other	35532186	hsa-mir-21	Hepatoblastoma	For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis.
other	35532186	hsa-mir-34a	Hepatoblastoma	For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis.
other	35532186	hsa-mir-34c	Hepatoblastoma	For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis.
other	35532186	hsa-mir-34b	Hepatoblastoma	For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis.
genetics_overexpression_suppress	35532178	hsa-mir-205	Bulimia Nervosa	Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes.
transcription factor target	35532075	hsa-mir-149	Endotoxemia	Collectively, resveratrol upregulated miR-149, downregulated HMGB1, and inhibited the ferroptosis pathway, thus improving cardiomyocyte injury in LPS-induced endotoxemia.NEW & NOTEWORTHY Sepsis is an unusual systemic reaction. This study explored the mechanism of resveratrol in sepsis by regulating the miR-149/HMGB1 axis.
other	35532070	hsa-mir-194	Kidney Diseases	5p in both age groups.
other	35532070	hsa-mir-24	Nephrosclerosis	5p in both age groups.
other	35532070	hsa-mir-194	familial febrile seizures 1	5p in both age groups.
other	35532070	hsa-mir-20a	Nephrosclerosis	5p in both age groups.
other	35532070	hsa-mir-24	familial febrile seizures 1	5p in both age groups.
other	35532070	hsa-mir-20a	Kidney Diseases	5p in both age groups.
other	35532070	hsa-mir-194	Nephrosclerosis	5p in both age groups.
other	35532070	hsa-mir-24	Kidney Diseases	5p in both age groups.
other	35532070	hsa-mir-20a	familial febrile seizures 1	5p in both age groups.
genetics_overexpression_promote	35531876	hsa-mir-146	Ovarian Insufficiency, Premature	In summary, we reveal the up-regulation of miRNA-146 expression mitigated ovarian dysfunction by negatively regulating expression of the IL-6 and TNF-a, which may shed light on the potential molecular mechanisms of overexpression of miRNA-146 may reversed the ovarian dysfunction by inhibiting the TLR4/ NF-kappaB signaling pathway.
lncRNA target	35531688	hsa-mir-148	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
lncRNA target	35531688	hsa-mir-181	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
lncRNA target	35531688	hsa-mir-350	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
lncRNA target	35531688	hsa-mir-20	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
lncRNA target	35531688	hsa-mir-21	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
lncRNA target	35531688	hsa-mir-155	Liver Cirrhosis	mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR
circulation_biomarker_diagnosis_ns	35531134	hsa-mir-33a	Diabetes Mellitus	The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM).
circulation_biomarker_diagnosis_ns	35531134	hsa-mir-33a	Diabetes Mellitus, Type 2	The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM).
circulation_biomarker_diagnosis_ns	35531134	hsa-mir-122	Diabetes Mellitus	The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM).
circulation_biomarker_diagnosis_ns	35531134	hsa-mir-122	Diabetes Mellitus, Type 2	The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM).
transcription factor target	35530951	hsa-mir-21	Colitis	Intravenous injection of miR-21 antagonists can effectively relieve the symptoms of colitis and inhibit colonic angiogenesis.
circulation_biomarker_diagnosis_ns	35530650	hsa-mir-1247	Pancreatic Diseases	RESULTS: The methylation rate of miR-1247 was significantly higher in patients with BTC than in those with BD, and tended to be higher in patients with PC than in those with BD. CONCLUSION: Methylation of miR-1247 in plasma may be useful to distinguish BTC from BD.
lncRNA target	35530496	hsa-mir-195	Leukemia, Myeloid, Acute	Conclusion: Our data indicated that ZFAS1 silencing alleviated ADR resistance of AML cells in vitro through acting as a sponge for miR-195 and regulating Myb expression.
circRNA target	35530358	hsa-mir-1263	Carcinoma, Hepatocellular	Mechanistic investigations revealed that circERBIN regulated HCC proliferation by acting as a sponge of miR-1263, which subsequently targeted cyclin dependent kinase 6 and controlled G1/S transition.
genetics_overexpression_promote	35530352	hsa-mir-29b	Thyroid Cancer, Papillary	Functional assays revealed that overexpression of COL1A1 or COL5A1 reversed the suppressive role of miR-29b-3p in migration, invasion, and EMT of PTC cells.
transcription factor target	35529491	hsa-mir-9	Muscular Diseases	In conclusion, the miR5p/Dlx3/Myf5 axis is a novel pathway for the regulation of myogenic differentiation, and can be a potential target to treat the diseases related to muscle dysfunction.
lncRNA target	35529258	hsa-mir-138	Hemangioma, Infantile	CONCLUSION: Hsa_circ_0003570 promotes IH cell proliferation and inhibits IH cell apoptosis through hsa-miR5p/RGS5 axis.
other	35529221	hsa-mir-205	Nasopharyngeal Carcinoma	Since microRNA-205 (miR-205) is a predictive biomarker for anti-radiation of nasopharyngeal carcinoma (NPC), quantitative detection of miR-205 is important for developing personalized strategies for the treatment of NPC.
target gene	35528911	hsa-mir-141	Osteosarcoma	Long non-coding RNA DLX6-AS1/miR-141-3p axis regulates osteosarcoma proliferation, migration and invasion through regulating Rab10.
transcription factor target	35528843	hsa-mir-21	Sepsis	CONCLUSIONS: The differentiation and function of Th17/Treg cells were regulated by miR-21 in sepsis through caspase pathway.
circulation_biomarker_diagnosis_ns	35528840	hsa-mir-181b	Diabetic Foot	Several datasets suggest that miR-181b-5p expression might be enriched in exosomes from DFU; this was verified using quantitative real-time PCR (qRT-PCR). In conclusion, this study indicated that circulating exosomal miR-181b-5p promoted cell senescence and inhibited angiogenesis to impair wound healing in DFU by regulating the NRF2/HO-1 pathway.
other	35528830	hsa-mir-451	Acute Lung Injury	RESULTS: LPS significantly increased lung inflammation, neutrophil infiltration, and oxidative stress and downregulated lung miR-451 expression.
other	35528669	hsa-mir-107	Alzheimer Disease	Berberine protected against Abeta(25-35)-induced inflammatory injury, apoptosis and phosphorylation of tau by regulating miR-107 and ZNF217, indicating berberine as a promising neuroprotective agent for therapeutics of AD.
genetics_overexpression_suppress	35528616	hsa-mir-615	Carcinoma, Hepatocellular	CONCLUSION: HAO2 was found to be underexpressed in HCC tissues and cells, and HAO2 overexpression inhibited HCC cell motility, which was negatively regulated by miR
circulation_biomarker_diagnosis_ns	35528582	hsa-mir-16	Arthritis, Rheumatoid	In this study, we firstly examined the miR-16 expression in the serum and synovial fluid from RA patients who were unresponsive to methotrexate monotherapy (UR-MTX patients) and responsive RA patients (R-MTX patients).
circulation_biomarker_diagnosis_up	35528582	hsa-mir-16	Uremia	In this study, we firstly examined the miR-16 expression in the serum and synovial fluid from RA patients who were unresponsive to methotrexate monotherapy (UR-MTX patients) and responsive RA patients (R-MTX patients). MiR-16 was upregulated in the in serum and synovial fluid from UR-MTX patients as well as in FLS-MTX cells.
other	35528544	hsa-mir-6088	Neurodegenerative Diseases	Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms.
other	35528544	hsa-mir-184	Neurodegenerative Diseases	Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms.
other	35528544	hsa-mir-4649	Neurodegenerative Diseases	Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms.
exosome	35528244	hsa-mir-6838	Thyroid Neoplasms	These results suggest that FGD5-AS1 in tumor-derived exoskeleton promotes angiogenesis, vascular permeability, and metastasis by regulating the endothelial miR5p/VAV2 axis and ultimately promotes the occurrence and development of TC.
other	35527788	hsa-let-7b	Colorectal Neoplasms	hsa_circ_0000523/miR-let-7b/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line.
lncRNA target	35527652	hsa-mir-125b	Rhinitis, Allergic	CONCLUSION: lnc-THRIL and its target (miR-125b) relate to disease risk, symptom severity, and Th1/Th2 imbalance of AR, suggesting their potential as biomarkers for AR management.
other	35527543	hsa-mir-758	Atherosclerosis	CONCLUSION: Circ_0093887 demonstrated its diagnostic and therapeutic value in AS by promoting the role of the miR3p/BAMBI axis in the ox-LDL-induced endothelial injury of HAECs.
lncRNA target	35527493	hsa-mir-20a	Lung Neoplasms	[miR-20a-5p inhibits proliferation of lung cancer A549 cells by down-regulating OBJECTIVE: To investigate the molecular mechanism by which miR-20a-5p regulates HOXB13 gene expression and inhibits lung cancer cell proliferation. CONCLUSION: miR-20a-5p inhibits proliferation of lung cancer cells by down-regulating the expression of HOXB13.
circulation_biomarker_diagnosis_up	35527417	hsa-mir-106b	Thrombocytopenia	The correlation analysis showed that in the children with ITP, the expression level of plasma miR-106b-5p was positively correlated with the Th17 level and the Th17/Treg ratio (r=0.730 and 0.816 respectively; P&lt;0.001) and was negatively correlated with the Treg level (r=-0.774, P&lt;0.001).
transcription factor target	35527277	hsa-mir-504	Alzheimer Disease	CONCLUSIONS: Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies.
transcription factor target	35527005	hsa-mir-34a	Liver Injury	Collectively, DEX could alleviate acute stress-induced liver injury through ROS/JNK/p38 signaling pathway via downregulation of miR-34a-5p.
other	35526722	hsa-mir-665	Osteoarthritis	CONCLUSION: Our findings unraveled that circ_0136474 promoted chondrocyte injury in IL-1beta-induced OA model by depending on the regulation of miR-665/FGFR1 axis.
circRNA target	35525959	hsa-mir-181a	Adenocarcinoma of Lung	Mechanistically, circHMGB2 relieves the inhibition of downstream CARM1 by sponging miR-181a-5p, thus inactivating the type 1 interferon response in the LUAD and LUSC.
other	35525840	hsa-mir-10b	Glioblastoma	MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients.
other	35525840	hsa-mir-34a	Glioblastoma	MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients.
circulation_biomarker_diagnosis_ns	35525722	hsa-mir-124	Carcinoma, Hepatocellular	AIMS: To correlate miRNA-29a and miRNA-124 expression levels with the clinical features and survival rates of HCC patients. RESULTS: The expression levels of serum miRNA-29a were higher and the levels of miRNA-124 were lower in patients with HCC than in patients with liver cirrhosis and controls.
circulation_biomarker_diagnosis_ns	35525722	hsa-mir-29a	Carcinoma, Hepatocellular	AIMS: To correlate miRNA-29a and miRNA-124 expression levels with the clinical features and survival rates of HCC patients. RESULTS: The expression levels of serum miRNA-29a were higher and the levels of miRNA-124 were lower in patients with HCC than in patients with liver cirrhosis and controls.
other	35524996	hsa-let-7a	Schizophrenia	5p/let-7a-5p-IL6 networks in course of the treatment of SZ.
other	35524996	hsa-mir-155	Schizophrenia	5p/let-7a-5p-IL6 networks in course of the treatment of SZ.
other	35524977	hsa-mir-873	Cardiomyopathies	To conclude, TDRG1 aggravates DCM progression by binding with miR5p to upregulate PRKAR2.
transcription factor target	35524907	hsa-mir-133a	Cardiotoxicity	The data suggest that miR-133a is associated with DOX-based cardiotoxicity during chemotherapy in breast cancer patients through ErbB2 signaling pathway. Moreover, miR-133a may be a future marker of DOX-induced cardiotoxicity in women with breast cancer.
transcription factor target	35524907	hsa-mir-133a	Breast Neoplasms	The data suggest that miR-133a is associated with DOX-based cardiotoxicity during chemotherapy in breast cancer patients through ErbB2 signaling pathway. Moreover, miR-133a may be a future marker of DOX-induced cardiotoxicity in women with breast cancer.
genetics_knock down_promote	35524876	hsa-mir-181a	Ovarian Neoplasms	The results reveal the knockdown of LINC00665 facilitates ovarian cancer via development by sponging miR-181a-5p and up-regulating FHDC1 expression.
genetics_GWAS	35524830	hsa-mir-17	Hepatitis C	3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR.
genetics_GWAS	35524830	hsa-mir-24	Hepatitis C	3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR.
genetics_GWAS	35524830	hsa-mir-223	Hepatitis C	3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR.
other	35524480	hsa-mir-125a	Inflammatory Bowel Diseases	CONCLUSION: Dioscin modulated macrophage polarization by increasing miR-125a-5p, thereby improving the intestinal epithelial barrier function and reducing IBD.
other	35524422	hsa-mir-203a	Thyroid Cancer, Papillary	In PTC, the role of miR-203a-3p and the underlying mechanisms remain not completely understood. RESULTS: We found that the levels of miRNA-203a-3p were statistically decreased in PTC tissues.
other	35524416	hsa-mir-137	Gout	The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout.
other	35524416	hsa-mir-23b	Gout	The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout.
other	35524416	hsa-mir-217	Gout	The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout.
other	35524416	hsa-mir-139	Gout	The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout.
other	35524416	hsa-mir-429	Gout	The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout.
circulation_biomarker_diagnosis_down	35524373	hsa-mir-155	Breast Neoplasms	The expression rate of miR-155 and its downstream target gene, SOCS-1, as well as the plasma levels of IL-6, were evaluated in peripheral blood mononuclear cells of NDBC patients; using real-time PCR and enzyme-linked immunosorbent assay, respectively.
circRNA target	35524319	hsa-mir-346	Carcinoma, Hepatocellular	CONCLUSIONS: CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis.
circRNA target	35524319	hsa-mir-874	Carcinoma, Hepatocellular	CONCLUSIONS: CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis.
lncRNA target	35524230	hsa-mir-17	Teratoid Rhabdoid Tumor, Atypical	5p may be a pivotal event in AT/RT and miRNAs that may represent potential therapeutic targets and diagnostic biomarkers.
other	35524161	hsa-mir-383	Esophageal Squamous Cell Carcinoma	5p to promote ESCC progression by upregulating KIAA0101, which provided a potential therapeutic strategy for ESCC treatment.
other	35523949	hsa-mir-513a	Lupus Nephritis	Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.
other	35523945	hsa-mir-128	Angelman Syndrome	Our study demonstrates that LSS could regulate the expression of EPHB2 in HAECs, and the LOC107986345/miR3p/EPHB2 axis plays a vital role in AS development.
lncRNA target	35523945	hsa-mir-128	Leigh Disease	Further research revealed the anti-inflammatory effect of LSS depends on autophagy activation resulting from the nuclear translocation of HMGB1 via the LOC107986345/miR
circulation_biomarker_diagnosis_up	35522909	hsa-mir-769	Stomach Neoplasms	5p was upregulated in GC tissues and enriched in the serum exosomes of cisplatin-resistant patients.
lncRNA target	35522362	hsa-mir-1294	Esophageal Squamous Cell Carcinoma	circ_0023984 facilitates the malignant biological behaviors of ESCC cells through inhibiting miR-1294 and activating PI3K/Akt/c-myc pathway.
other	35522176	hsa-mir-20a	Atherosclerosis	MiR-320a was highly expressed, whereas RGS5 showed low levels of expression in the arterial plaque tissues.
other	35521936	hsa-mir-217	Head and Neck Neoplasms	In addition, copy number alterations (CNAs) of INHBA and miR5p downregulation are potential mechanisms for elevated INHBA expression in HNSC.
genetics_GWAS	35521898	hsa-mir-485	Adenocarcinoma of Lung	3p-NEK4 axis might halt the tumor-inhibiting role of propofol in LUAD cells in vitro, suggesting a potential epigenetic pathway of propofol.
circulation_biomarker_diagnosis_ns	35521768	hsa-mir-146b	Thyroid Neoplasms	Among the six candidates, only miR-146b-5p and miR-21a-5p displayed a significant differential abundance in purified plasma-derived EVs from patients with PTC and benign disease.
circulation_biomarker_diagnosis_ns	35521768	hsa-mir-21	Thyroid Neoplasms	Among the six candidates, only miR-146b-5p and miR-21a-5p displayed a significant differential abundance in purified plasma-derived EVs from patients with PTC and benign disease.
lncRNA target	35521747	hsa-mir-6509	Stomach Neoplasms	Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR
other	35521691	hsa-mir-4715	Non-alcoholic Fatty Liver Disease	The miR3p/GSDMD axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD.
other	35521691	hsa-mir-4715	Diabetic Nephropathies	The miR3p/GSDMD axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD.
target gene	35521597	hsa-mir-425	Triple Negative Breast Neoplasms	miR-425 suppresses EMT and the development of TNBC (triple-negative breast cancer) by targeting the TGF-β 1/SMAD 3 signaling pathway.
genetics_knock down_promote	35520918	hsa-mir-148b	Leukemia, Myeloid, Acute	Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b.
genetics_knock down_promote	35520918	hsa-mir-148	Leukemia, Myeloid, Acute	Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b.
genetics_knock down_promote	35520918	hsa-mir-148a	Leukemia, Myeloid, Acute	Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b.
genetics_knock down_suppress	35520785	hsa-mir-126	Thyroid Cancer, Papillary	Conclusion: CircPVT1 knockdown inhibited PTC progression by sponging miR-126.
circulation_biomarker_diagnosis_up	35519896	hsa-mir-486	Sepsis	Our data supported that miR-486 was upregulated in the serum of sepsis patients.
target gene	35519367	hsa-let-7d	Pulmonary Fibrosis	miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis.
target gene	35519332	hsa-mir-185	Colorectal Neoplasms	Long non coding RNA UCA1 contributes to the autophagy and survival of colorectal cancer cells via sponging miR-185-5p to up-regulate the WISP2/β-catenin pathway.
target gene	35518787	hsa-mir-21	Carcinoma, Hepatocellular	JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.
lncRNA target	35517895	hsa-mir-122	non-alcoholic steatohepatitis	Conclusion: trans-Chalcone could inhibit the transition from steatosis to NASH through the modulation of miR-122, 21, 34a, and 451 expression levels in the liver.
target gene	35517889	hsa-mir-193a	Stomach Neoplasms	microRNA-193a-5p Suppresses the Migratory Ability of Human KATO III Gastric Cancer Cells through Inhibition of Vimentin and MMP-9.
target gene	35517885	hsa-mir-143	Stomach Neoplasms	Restoration of miRNA-143 Expression Inhibits Growth and Migration of MKN-45 Gastric Cancer Cell Line.
other	35517862	hsa-mir-335	Colonic Neoplasms	Five hub genes co-expressed with SLC7A11 that induce ferroptosis were identified, and mir5p, RELA, and securinine have regulatory effects on it.
other	35517418	hsa-mir-1247	Adenocarcinoma of Lung	Conclusions: miR3p acted as a potential governor monitoring cell migration and chemotherapy resistance of LUAD by interacting with STAT5A.
target gene	35517414	hsa-mir-4723	Pancreatic Neoplasms	CAV2 Regulates Mir-4723/Wnt7A Signalling Axis through Endocytosis and Epithelial-Mesenchymal Transition to Promote Proliferation, Invasion, and Metastasis of Pancreatic Cancer Cells.
lncRNA target	35517408	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	The data suggests that miR-199a-5p can inhibit glucose metabolism in NSCLC by targeting SLC2A1.This study proves that miR-199a-5p / SLC2A1 can play an essential role in the development of NSCLC by targeting SLC2A1.
lncRNA target	35517406	hsa-mir-873	Glioma	Moreover, WZY-321 treatment decreased miR-873 expression and increased lncRNA MTM expression in glioma cells, and down-regulated miR-873 or up-regulated MTM lead to glioma cell apoptosis. Taken together, these data indicate that WZY-321 triggers glioma cell apoptosis via XAF1 up-regulation caused by MTM-mediated miR-873 down-regulation.
lncRNA target	35516861	hsa-mir-377	Melanoma	3p suppressed melanoma cell growth partly mediated via the ARMC8 expression.
other	35516838	hsa-mir-210	Skeletal Muscular Injury, Non-Ischemic	The increase in hif1alpha level was observed just after the muscular injury in this non-ischemic tissue injury model, and the elevation in microRNA-210 level was noted at the initiation of tissue regeneration, indicating its effects on tissue protection and repair.
lncRNA target	35516319	hsa-mir-34a	Angelman Syndrome	Conclusion: Metformin facilitated proliferation and inhibited apoptosis of macrophages treated with Ox-LDL through the miR-34a/Bcl2 axis, indicating the potential value of metformin in AS therapy.
lncRNA target	35515212	hsa-mir-346	Stomach Neoplasms	Collectively, circSMARCA5 exhibited a tumor suppressor-like activity in gastric cancer via regulating the miR-346/FBXL2 axis.
genetics_overexpression_promote	35514986	hsa-mir-582	Precursor Cell Lymphoblastic Leukemia-Lymphoma	overexpressing BCP-ALL cells.
target gene	35514612	hsa-mir-124	Carcinoma, Non-Small-Cell Lung	miR-124 and miR-142 enhance cisplatin sensitivity of non-small cell lung cancer cells through repressing autophagy via directly targeting SIRT1.
target gene	35514612	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	miR-124 and miR-142 enhance cisplatin sensitivity of non-small cell lung cancer cells through repressing autophagy via directly targeting SIRT1.
lncRNA target	35514319	hsa-mir-205	Lung Neoplasms	Taken together, our findings suggest that miR2055p is a key gene targeted by ICA to inhibit lung cancer progression.
lncRNA target	35513844	hsa-mir-15a	Endometriosis	AFAP1-AS1 bound to BCL9, which was targeted by miR-15a-5p in EMS.
circRNA target	35513835	hsa-mir-5003	Uterine Cervical Neoplasms	CONCLUSIONS: As a tumour suppressor, circ_0087429 regulated by EIF4A3 can reverse EMT and inhibit the progression of cervical cancer through the miR
other	35513595	hsa-mir-151a	Atrial Fibrillation	5p and miR-151a-5p.
other	35513595	hsa-mir-155	Atrial Fibrillation	5p and miR-151a-5p.
other	35513595	hsa-mir-181a	Atrial Fibrillation	5p and miR-151a-5p.
other	35513595	hsa-mir-191	Atrial Fibrillation	5p and miR-151a-5p.
other	35513595	hsa-mir-122	Atrial Fibrillation	5p and miR-151a-5p.
circulation_biomarker_diagnosis_ns	35513513	hsa-mir-141	Carcinoma, Non-Small-Cell Lung	The developed biosensor can be successfully used in the early detection of non-small cell lung cancer (NSCLC) by directly measuring miR-141 in human plasma samples.
epigenetics	35512257	hsa-mir-124-2	Cervical Intraepithelial Neoplasia	In this multicenter longitudinal cohort study of women with untreated CIN2/3, the prognostic value of FAM19A4/miR124-2 methylation was evaluated for clinical regression. CONCLUSION: Most women with untreated CIN2/3 and a negative baseline FAM19A4/miR124-2 methylation test showed clinical regression.
other	35511922	hsa-mir-210	Leukemia, Myeloid, Acute	5p is found in AML patients in complete remission.
other	35511922	hsa-mir-28	Leukemia, Myeloid, Acute	5p is found in AML patients in complete remission.
transcription factor target	35511493	hsa-mir-21	Breast Neoplasms	5p/Tiam1/PFKL signaling pathway may serve as a target for new anti-BC therapeutic strategies.
genetics_GWAS	35511436	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	We also found that CLL cells directly regulated miR155 levels in Tn cells, thereby affecting Th17 differentiation, by documenting that coculturing Tn cells with resting or activated (Bact) CLL cells altered the magnitude and direction of T cell miR155 levels; CLL Bact cells promoted IL-17A+ and IL-17F+ T cell generation by an miR155-dependent mechanism, confirmed by miR155 inhibition; coculture of Tn cells with CLL Bact cells led to a linear correlation between the degree and direction of T cell miR155 expression changes and production of IL-17F but not IL-17A; and Bact cell-mediated changes in Tn cell miR155 expression correlated with outcome, irrespective of IGHV mutation status, a strong prognostic indicator.
circulation_biomarker_diagnosis_up	35511316	hsa-mir-203a	Colorectal Neoplasms	CONCLUSION: This study's findings revealed that serum miR-203a-3p is a fair non-invasive molecular biomarker for diagnosing and progressing tumor grade, tumor stage, and lymph node metastasis in colorectal cancer.
other	35511299	hsa-mir-21	Lung Neoplasms	PURPOSE: MicroRNA-21 (miR-21) is a well-known oncomiR and plays key roles in regulating various biological processes related to pulmonary diseases, especially lung carcinoma.
other	35511299	hsa-mir-21	Lung Diseases	PURPOSE: MicroRNA-21 (miR-21) is a well-known oncomiR and plays key roles in regulating various biological processes related to pulmonary diseases, especially lung carcinoma.
other	35511171	hsa-mir-101	Carcinoma, Hepatocellular	(2) The noncoding RNA miR3142HG and the LINC00265/has-miR3p axis were found to regulate MELK expression in HCC tissue.
other	35511171	hsa-mir-142	Carcinoma, Hepatocellular	(2) The noncoding RNA miR3142HG and the LINC00265/has-miR3p axis were found to regulate MELK expression in HCC tissue.
genetics_knock down_promote	35510828	hsa-mir-31	Pancreatic Carcinoma	Gain- and loss-of-function assays were also implemented to assess the role of miR
other	35510812	hsa-mir-455	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: CHRDL1 plays a vital role in promoting cancer in OSCC and is down-regulated at the mRNA levels by hsa-miR3p.
other	35510740	hsa-mir-133a	Muscular Atrophy, Spinal	CONCLUSIONS: Lower miR-206 and miR-133a-3p in the CSF predict more robust clinical response to nusinersen treatment in later onset SMA patients.
other	35510740	hsa-mir-206	Muscular Atrophy, Spinal	CONCLUSIONS: Lower miR-206 and miR-133a-3p in the CSF predict more robust clinical response to nusinersen treatment in later onset SMA patients.
lncRNA target	35510522	hsa-mir-7	Stomach Neoplasms	Microarray analysis suggested that microRNA-7 (miR-7) was the most upregulated miRNA in GC cells after curcumol treatment. In summary, this study suggests that curcumol sensitizes GC cells to cisplatin via miR-7 and the suppression of the NF-kappaB/SNAIL axis.
lncRNA target	35510394	hsa-mir-340	Reperfusion Injury, Cerebral Ischemia	All in all, this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA5p/DEAD-box helicase 5 axis.
circRNA target	35510365	hsa-mir-578	Sepsis	These results indicate that circSTRN3 upregulation in sepsis-induced AKI modulates miR-578/TLR4 axis to promote the pathogenesis of AKI, which could serve as future therapeutic targets for AKI treatment.
circRNA target	35510365	hsa-mir-578	Acute Kidney Injury	These results indicate that circSTRN3 upregulation in sepsis-induced AKI modulates miR-578/TLR4 axis to promote the pathogenesis of AKI, which could serve as future therapeutic targets for AKI treatment.
transcription factor target	35510354	hsa-mir-103a	Acute Kidney Injury	MiR-103a-3p was significantly repressed in the sepsis model, while CXCL12 was elevated. Collectively, miR-103a-3p heightens renal cell damage caused by sepsis by targeting CXCL12.
transcription factor target	35510354	hsa-mir-103a	Sepsis	MiR-103a-3p was significantly repressed in the sepsis model, while CXCL12 was elevated. Collectively, miR-103a-3p heightens renal cell damage caused by sepsis by targeting CXCL12.
other	35510269	hsa-mir-6325	Neuralgia	CONCLUSION: In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP.
other	35510208	hsa-mir-146	Prostatic Neoplasms	CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth.
other	35510208	hsa-mir-142	Prostatic Neoplasms	CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth.
circulation_biomarker_diagnosis_up	35510208	hsa-mir-21	Prostatic Neoplasms	In this study, we determined the levels of circulating miR-21, miR-142, miR-143, miR-146a, and RNU 44 levels as controls for early diagnosis of PCa.
other	35510208	hsa-mir-143	Prostatic Neoplasms	CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth.
other	35510208	hsa-mir-146a	Prostatic Neoplasms	CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth.
genetics_overexpression_promote	35509860	hsa-mir-377	Triple Negative Breast Neoplasms	3p were overexpressed or knocked down in the TNBC cells, respectively.
other	35509844	hsa-mir-429	Stomach Neoplasms	RESULTS: In gastric cancer, the circ-0007707/miR-429/PDGFD pathway had a differential expression. CONCLUSION: The circ-0007707/miR-429/PDGFD pathway may play a regulatory role in the progression and prognosis of gastric cancer by interfering with the tumor microenvironment, and the PDGFD-related immune-gene signature could be considered a moderator of prognostic factor for gastric cancer and to guide immunotherapy programs.
transcription factor target	35509839	hsa-mir-9	Parkinson Disease	5p might be a potential therapeutic target against Parkinson's disease.
epigenetics	35509266	hsa-mir-495	Periodontitis	3p expression by demethylation of H3K4me3 to enhance HOXC8 transcription, thereby increasing the HOXC8 and limiting OD, proliferation, and migration of hPDLSCs with periodontitis.
circRNA target	35509064	hsa-mir-516a	Carcinoma, Hepatocellular	Moreover, circTOLLIP sponged miR-516a-5p to elevate the expression of PBX3, thereby activating the epithelial-to-mesenchymal transition (EMT) pathway and facilitating tumor progression in HCC. CONCLUSIONS: Our findings indicate that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis.
other	35508523	hsa-mir-421	Colorectal Neoplasms	Additionally, SP1 could facilitate the tumorigenesis of CRC cells in vivo by regulating the TUG1/miR-421/KDM2A/ERK axis. Altogether, the current study emphasizes the oncogenic role of TUG1 in CRC, and illustrates its interactions with the upstream transcription factor SP1 and the downstream modulatory axis miR-421/KDM2A/ERK, thus offering novel insights into the cancerogenic mechanism in CRC.
lncRNA target	35508470	hsa-mir-17	Osteoarthritis	Supplementation of exogenous miR-17 or its endogenous induction by growth differentiation factor 5, effectively prevented OA by simultaneously targeting pathological catabolic factors including matrix metallopeptidase-3/13 (MMP3/13), aggrecanase-2 (ADAMTS5), and nitric oxide synthase-2 (NOS2).
lncRNA target	35508298	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	Moreover, the expression analysis, correlation analysis, and survival analysis revealed that POSTN-targeted miRNAs, downregulation of has-miR3p and has-miR-30e-3p, were significantly linked to poor prognosis in patients with LUSC.
genetics_GWAS	35507777	hsa-mir-125b	Hypertension, Pulmonary	miRNA-sequencing analysis of the genetic cargo of MSC-NVs revealed that miR-125b-5p and miR
genetics_GWAS	35507777	hsa-mir-100	Hypertension, Pulmonary	miRNA-sequencing analysis of the genetic cargo of MSC-NVs revealed that miR-125b-5p and miR
lncRNA target	35507744	hsa-mir-144	Microvascular Obstruction	3p targeted ROCK1 to radically activate the PI3K/AKT/mTOR pathway.
circulation_biomarker_diagnosis_up	35507256	hsa-mir-203	ST Elevation Myocardial Infarction	Logistic regression analysis showed that miRNA-203 and white blood cell counts were independent risk factors for STEMI (P<0.05), and their ORs (95% CI) were 3.913 (1.574-9.728) and 2.13 (1.247-3.641), respectively.
genetics_GWAS	35506422	hsa-mir-130a	Carcinoma, Renal Cell	Furthermore, exogenetic expression of CEP55 counteracted miR-130a-3p overexpression-mediated effects on malignant phenotypes and angiogenesis of RCC cells.
circulation_biomarker_diagnosis_up	35506414	hsa-mir-24	Pre-Eclampsia	3p and 11beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) was analyzed in the blood and cells.
circRNA target	35506311	hsa-mir-148a	Duane Retraction Syndrome	miR-148a-3p is downregulated in DR patients. As the molecular sponge of miR-148a-3p, circFTO regulated cell viability and apoptosis and promoted the progression of DR through regulating the expression of TGFA.
other	35506305	hsa-mir-101	Respiratory Distress Syndrome	3p plays a role in PARDS, providing a novel angle to study the disease.
circulation_biomarker_diagnosis_up	35506298	hsa-mir-155	Respiratory Distress Syndrome	We found significant upregulation of miR5p expression in serum samples from patients with ARDS compared with the control group (p < 0.01).
genetics_overexpression_promote	35506252	hsa-mir-940	Squamous Cell Carcinoma of Head and Neck	BBOX1-AS1 and LAMC2 were notably overexpressed in OSCC, while miR
other	35506187	hsa-mir-218	Norrie disease	OBJECTIVES: Since inflammation plays a key role in DN, and SPRED2 is known to facilitate cell autophagy, the present study aimed to investigate the role and molecular mechanism of miR-218 and SPRED2-mediated autophagy in high glucose (HG)-induced renal tubular epithelial cells using an in vitro model.
other	35506187	hsa-mir-218	Diabetes Mellitus	MicroRNA (miR)-218 is associated with the development of diabetes.
transcription factor target	35506187	hsa-mir-218	Inflammation	Besides, sprouty-related EVH1 domain containing 2 (SPRED2), the downstream target of miR-218, is involved in insulin resistance and inflammation.
lncRNA target	35506168	hsa-mir-491	Glioblastoma	Silencing H19 inhibited growth and promoted apoptosis in GBM cells both in vitro and in vivo, and miR
exosome	35506070	hsa-mir-210	Hypertension, Pulmonary	We found that the amount of pro-proliferative miR3p was increased in PVEC-derived EV in hypoxia (H-EV), which contributes to the H-EV-induced proliferation of PASMC and the development of PH.
other	35505969	hsa-mir-766	Thyroid Cancer, Papillary	A diagnostic and predictive lncRNA lnc-MPEG1-1 promotes the proliferation and metastasis of papillary thyroid cancer cells by occupying miR-766-5p.
genetics_overexpression_suppress	35505968	hsa-mir-10a	Diabetic Nephropathies	Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD.
genetics_overexpression_suppress	35505968	hsa-mir-10b	Diabetic Nephropathies	Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD.
genetics_overexpression_suppress	35505968	hsa-mir-10a	Fibrosis, Renal	Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD.
genetics_overexpression_suppress	35505968	hsa-mir-10b	Fibrosis, Renal	Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD.
genetics_overexpression_promote	35505304	hsa-mir-618	Colorectal Neoplasms	CONCLUSION: Circ-ATAD1 is overexpressed in CRC and may suppress miR-618 maturation to participate in CRC.
other	35505296	hsa-mir-33a	Diabetes, Gestational	qPCR analysis indicated that LINC00667, YTHDF3 and MYC levels were upregulated in the GDM placentas, while miR-33a-5p was downregulated. In a support-vector machine classifier, an m6A-related module composed of LINC00667, YTHDF3, MYC, and miR-33a-5p showed excellent classifying power for GDM in both the training and the testing dataset, with an accuracy of 76.19 and 71.43%, respectively.
epigenetics	35505294	hsa-mir-138	Uterine Cervical Neoplasms	CONCLUSION: We demonstrated that miR-138 suppresses tumor progression by targeting EZH2 in cervical cancer and uncovered the role of DNA methylation in the miR-138 promoter in its downregulation.
lncRNA target	35504804	hsa-mir-21	Intestinal Diseases	RESULTS: Compared to the controls, miR-21 was significantly upregulated in the intestinal tissues from CD patients with fibro stenosis, followed by decreased PTEN expression, increased EMT markers, and mTOR expression, and imbalanced ratio of MMP9(matrix metalloproteinase 9)/TIMP1(tissue inhibitor of metalloproteinase 1).
lncRNA target	35504804	hsa-mir-21	Crohn Disease	RESULTS: Compared to the controls, miR-21 was significantly upregulated in the intestinal tissues from CD patients with fibro stenosis, followed by decreased PTEN expression, increased EMT markers, and mTOR expression, and imbalanced ratio of MMP9(matrix metalloproteinase 9)/TIMP1(tissue inhibitor of metalloproteinase 1).
lncRNA target	35504332	hsa-mir-217	Pancreatic Carcinoma	Therefore, hsa-miR-217 abrogates pancreatic cancer progression through inactivation of the AKT signaling pathway and this might be partly due to miR-217 mediated suppression of ATAD2 expression. SIGNIFICANCE: The application of hsa-miR-217 mimic could be a promising therapeutic strategy for the treatment of pancreatic cancer patients in near future.
lncRNA target	35504176	hsa-mir-1290	Esophageal Squamous Cell Carcinoma	Collectively, our study demonstrates that ZNF667-AS1 can function as a tumor suppressor in ESCC by upregulating PRUNE2 and downregulating miR-1290.
lncRNA target	35504053	hsa-mir-103a	Endometriosis	Given the existing literature and our predictions through starBase in this research, it was assumed that circATRNL1 might orchestrate the microRNA (miR)- 103a-3p/acid-sensing ion channel 1 (ASIC1) axis to control EMT in endometriosis.
lncRNA target	35503998	hsa-mir-183	Urinary Bladder Neoplasms	OBJECTIVE: To uncover novel prognostic and therapeutic targets for BLCA, our study is the first to investigate the role of hsa-mir-183 and its up-regulated predicted target genes in bladder urothelial carcinoma. METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases.
other	35503860	hsa-mir-21	Breast Neoplasms	Herein, the upconversion nanoparticle@Au (UCNP@Au) core-satellite nanostructures are rationally fabricated for isothermal amplification detection and in situ imaging of microRNA-21 (miR-21) in living cells based on the toehold-mediated strand displacement (TMSD) reaction, which is further applied to miRNA-responsive combined photothermal and photodynamic therapy of breast cancer.
transcription factor target	35503501	hsa-mir-1273d	Pre-Eclampsia	EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia.
transcription factor target	35503501	hsa-mir-4492	Pre-Eclampsia	EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia.
transcription factor target	35503501	hsa-mir-4417	Pre-Eclampsia	EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia.
genetics_overexpression_suppress	35503407	hsa-mir-196b	Esophageal Neoplasms	Overexpressed ADAMTS9-AS2 regulated the tumor-forming ability of EC cells in vivo through miR-196b-5p/PPP1R12B/cell cycle signaling pathway axis.
lncRNA target	35503215	hsa-mir-182	Myocardial Reperfusion Injury	5p regulates the apoptosis and ROS and protects against myocardial I/R injury by targeting STK17A.
exosome	35503135	hsa-mir-130a	Myocardial Reperfusion Injury	The protective action of EV-carried miR-130a-3p was further re-produced in a rat model serving as in vivo validation as evidenced by improved cardiac function, tissue injury, myocardial fibrosis, and myocardial infarction.
other	35503041	hsa-mir-195	Aortic Aneurysm, Thoracic	Tissue expression of microRNA 195 was 2.72-fold higher in the dissection (P < .001) and 2.00-fold lower in the aneurysm group (P = .08), compared with to the control group.
genetics_overexpression_promote	35502885	hsa-mir-766	Squamous Cell Carcinoma of Head and Neck	5p inhibition and overexpression of HMGA2 rescued the tumor-suppressing roles of circSHKBP1 downregulation in LSCC.
target gene	35502349	hsa-mir-124	Melanoma	LncRNA LNCOC1 is Upregulated in Melanoma and Serves as a Potential Regulatory Target of miR-124 to Suppress Cancer Cell Invasion and Migration.
circulation_biomarker_diagnosis_up	35501921	hsa-mir-21	Ovarian Neoplasms	METHODS: Databases, such as PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China WanFang, were searched for relevant studies upon the correlation between the expression of serum miR-21 and the diagnostic value of ovarian cancer from inception to March 7, 2022.
genetics_knock down_promote	35501825	hsa-mir-600	Ovarian Neoplasms	Si-KLF9 partially abolished the discrepancy of self-renewal, growth and metastasis capacity between miR-600 knockdown ovarian cancer cells and control cells.
circulation_biomarker_prognosis_ns	35501813	hsa-mir-182	Cardiomegaly	ROC curve indicated the diagnostic value of serum miR
lncRNA target	35501800	hsa-mir-144	Urinary Bladder Neoplasms	CONCLUSION: Our data demonstrate that ZBTB7A, a targeted gene of miR
circulation_biomarker_diagnosis_up	35501673	hsa-mir-196b	Colorectal Neoplasms	In plasma, miR-196b-5p was the most sensitive (0.97; p &lt; .001) and specific (0.94; p &lt; .001) in detecting CRC.
circRNA target	35501594	hsa-mir-93	Uterine Cervical Neoplasms	5p, and down-regulated FRMD6 reversed the cell viability, migration and invasion of cervical cancer cells inhibited by anti-miR
other	35501543	hsa-mir-214	Heart Failure, Chronic	Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation.
other	35501543	hsa-let-7i	Heart Failure, Chronic	Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation.
other	35501543	hsa-let-7g	Heart Failure, Chronic	Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation.
transcription factor target	35501542	hsa-mir-16	Graft Occlusion, Vascular	The miR5p/zyxin axis is a novel, potentially therapeutic target for preventing and treating venous graft intimal hyperplasia.
transcription factor target	35501542	hsa-mir-16	Endometrial Hyperplasia	The miR5p/zyxin axis is a novel, potentially therapeutic target for preventing and treating venous graft intimal hyperplasia.
genetics_knock down_promote	35501464	hsa-mir-622	Prostatic Neoplasms	In addition, miR-3622 KO inhibited the epithelial-mesenchymal transition involved in prostate cancer metastasis via upregulation of vimentin.
exosome	35501306	hsa-mir-1298	Glioma	Interestingly, exosomal miR
genetics_overexpression_suppress	35500803	hsa-mir-1283	Carcinoma, Hepatocellular	MiR-1283 inhibitor incompletely counteracted the effect of si-circ_0005397 on HCC cell progression, while HEG1 overexpression partially overturned the effect of miR-1283 on HCC cell progression. CONCLUSIONS: Circ_0005397 regulated HEG1 by targeting miR-1283, thereby promoting HCC development.
other	35500644	hsa-mir-155	COVID-19	The aim of this study was to investigate the expression patterns of inflammation-related non-coding RNAs (ncRNAs) including MALAT-1, NEAT-1, THRIL, and miR5p from the acute phase to the recovery phase of COVID-19.
other	35500644	hsa-mir-150	COVID-19	DISCUSSION: Inflammation-related ncRNAs (MALAT-1, THRIL, and miR5p) can act as hopeful biomarkers for the monitoring and diagnosis of COVID-19 disease.
circRNA target	35500159	hsa-mir-615	Carcinoma, Non-Small-Cell Lung	5p/PAK1 axis, which might provide a new therapeutic target for NSCLC treatment.
other	35500065	hsa-mir-299	Thyroid Cancer, Papillary	5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance.
other	35500065	hsa-mir-376a	Thyroid Cancer, Papillary	5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance.
other	35500065	hsa-mir-154	Thyroid Cancer, Papillary	5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance.
other	35499677	hsa-mir-6024	Necrobiotic Disorders	With the elucidation of the necrotrophic disease-synergistic role played by miR6024, it becomes a potent candidate for biotechnological manipulation for the rapid development of pathogen-tolerant solanaceous plants.
genetics_overexpression_promote	35499320	hsa-mir-149	Triple Negative Breast Neoplasms	In rescue assays, it was proven that overexpressing CTCF and CTNNB1 or inhibiting miR
genetics_GWAS	35499218	hsa-mir-196a-2	Esophageal Neoplasms	To investigate the relationship between miR-146a rs2910164 C&gt;G, miR-196a2 rs11614913 T&gt;C, and miR-499 rs3746444 A&gt;G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study.
genetics_GWAS	35499218	hsa-mir-146a	Esophageal Neoplasms	To investigate the relationship between miR-146a rs2910164 C&gt;G, miR-196a2 rs11614913 T&gt;C, and miR-499 rs3746444 A&gt;G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study.
genetics_GWAS	35499218	hsa-mir-499	Esophageal Neoplasms	To investigate the relationship between miR-146a rs2910164 C&gt;G, miR-196a2 rs11614913 T&gt;C, and miR-499 rs3746444 A&gt;G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study.
lncRNA target	35499148	hsa-mir-34c	Pulmonary Fibrosis	Dysregulation of microRNA-34c (miR-34c) is highly correlated with organ fibrosis including pulmonary fibrosis.
genetics_overexpression_suppress	35499128	hsa-mir-145	Breast Neoplasms	Meanwhile, miR-145 overexpression facilitated the docetaxel sensitivity of BC cells in vivo and in vitro, while the miR-145 inhibitor decreased the sensitivity of BC cells to docetaxel.
genetics_overexpression_promote	35499081	hsa-mir-21	Lupus Erythematosus, Systemic	Using human cells and murine models, the authors demonstrated that miR-21 was overexpressed in lupus T cells and inhibited 3-hydroxybutyrate dehydrogenase-2 (BDH2).
other	35499057	hsa-mir-532	Uterine Cervical Neoplasms	5p/orlistat as novel strategy for treating patients with LNM in CC.
lncRNA target	35498540	hsa-mir-185	Laryngeal Neoplasms	In conclusion, LINC01278 plays an oncogenic role in laryngeal cancer by suppressing miR5p to enhance CST1 expression, which enriches the molecular mechanism for the carcinogenesis of laryngeal cancer.
circulation_biomarker_diagnosis_ns	35498403	hsa-mir-21	Non-alcoholic Fatty Liver Disease	5p levels were higher in children with IR and NAFLD, and their expression levels correlated with hepatic fat and serum triglyceride.
circulation_biomarker_diagnosis_ns	35498403	hsa-mir-155	Non-alcoholic Fatty Liver Disease	3p levels correlated with plasma adiponectin (r = -0.71 and r = -0.75, respectively, p<0.05) and fibroblast growth factor-21 (r = -0.73 and r = -0.89, respectively, p<0.01).
circulation_biomarker_diagnosis_ns	35498403	hsa-mir-22	Non-alcoholic Fatty Liver Disease	3p levels correlated with plasma adiponectin (r = -0.71 and r = -0.75, respectively, p<0.05) and fibroblast growth factor-21 (r = -0.73 and r = -0.89, respectively, p<0.01).
other	35498402	hsa-mir-155	Diabetes Of The Exocrine Pancreas 	5p-TLR4 might lead to TLR4 signaling pathway activation in DEP.
other	35498402	hsa-mir-21	Diabetes Of The Exocrine Pancreas 	5p-TLR4 might lead to TLR4 signaling pathway activation in DEP.
other	35498402	hsa-mir-27a	Diabetes Of The Exocrine Pancreas 	5p-TLR4 might lead to TLR4 signaling pathway activation in DEP.
lncRNA target	35498204	hsa-mir-375	Cardiomyopathies	3p promoted fibrosis by accelerating the ferroptosis of cardiomyocytes through mediating glutathione peroxidase 4 (GPX4).
circulation_biomarker_diagnosis_ns	35498136	hsa-mir-24	Blood Coagulation Disorders, Traumatic, Acute	Both the liver tissues of ATC rats and peripheral blood samples from ATC patients showed increased hsa-miR
circulation_biomarker_diagnosis_ns	35498018	hsa-let-7c	Hypertension	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
circulation_biomarker_diagnosis_ns	35498018	hsa-mir-145	Hypertrophy, Left Ventricular	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
circulation_biomarker_diagnosis_ns	35498018	hsa-mir-145	Hypertension	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
circulation_biomarker_diagnosis_ns	35498018	hsa-mir-451	Hypertrophy, Left Ventricular	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
circulation_biomarker_diagnosis_ns	35498018	hsa-mir-451	Hypertension	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
circulation_biomarker_diagnosis_ns	35498018	hsa-let-7c	Hypertrophy, Left Ventricular	CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling.
transcription factor target	35497882	hsa-mir-3918	Glioma	The results of KEGG revealed that the targeting genes of hsa-miR-3918 were primarily related to MAPK signal pathway, PI3K-Akt signal pathway, and human papillomavirus infection.
transcription factor target	35497882	hsa-mir-3918	Primary Central Nervous System Lymphoma	The results of KEGG revealed that the targeting genes of hsa-miR-3918 were primarily related to MAPK signal pathway, PI3K-Akt signal pathway, and human papillomavirus infection.
lncRNA target	35497876	hsa-mir-22	Colorectal Neoplasms	Taken together, SETDB1 could activate the BATF3/PD-L1 axis by inhibiting FOSB-mediated miR-22 and promote immune evasion in CRC, which provides a better understanding of the mechanisms underlying immune evasion in CRC.
lncRNA target	35497503	hsa-mir-122	Hepatitis C	Formerly, we were able to inhibit hepatitis C virus propagation by applying a circular RNA decoy strategy against microRNA-122, which is essential for the viral life cycle.
genetics_overexpression_promote	35495878	hsa-mir-93	Urinary Bladder Neoplasms	5p overexpression promoted BUC cell abilities.
other	35495611	hsa-mir-20a	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495611	hsa-mir-146a	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495611	hsa-mir-204	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495611	hsa-let-7c	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495611	hsa-let-7b	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495611	hsa-let-7d	Chronic Pelvic Pain Syndrome	Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed.
other	35495596	hsa-mir-125b	Abortion, Habitual	In the present study, the expression of NEAT1 and Bcl-2 was reduced and that of miR-125b was increased in clinical samples of villus tissues from patients with RSAs.
other	35495318	hsa-mir-21	Kidney Diseases	MicroRNA-21 (miRNA-21) is a significant biomarker which is closely related to some kinds of diseases, such as cancer, cardiovascular disease and kidney disease.
other	35495318	hsa-mir-21	Cardiovascular Diseases	MicroRNA-21 (miRNA-21) is a significant biomarker which is closely related to some kinds of diseases, such as cancer, cardiovascular disease and kidney disease.
genetics_GWAS	35495171	hsa-let-7a	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-149	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-219a	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-132	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-10b	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-26a	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-143	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-mir-499	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
genetics_GWAS	35495171	hsa-let-7i	Uterine Cervical Neoplasms	Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed.
other	35495167	hsa-mir-429	Rectal Neoplasms	Fourthly, we constructed a rectal cancer-related ceRNA network and detected several typical lncRNA-miRNA-mRNA crosstalk, such as HAND2-AS1, HAND2 and miR-20a-5p crosstalk and MBNL1-AS1, miR-429 and LONRF2 crosstalk, which were validated to function in improving overall survival of rectal cancer patients.
circulation_biomarker_diagnosis_up	35494527	hsa-mir-100	Pulmonary Disease, Chronic Obstructive	CONCLUSION: miR-100 and TRIB2 were expressed abnormally in serum of COPD patients, and miR-100 could inhibit proliferation of pulmonary fibroblasts and promote their apoptosis.
lncRNA target	35494514	hsa-mir-129	Arthritis, Rheumatoid	5p, and BRD4 upregulation could partly rescue the inhibition of miR
lncRNA target	35494512	hsa-mir-4504	Colorectal Neoplasms	NBAT-1 bound miR-4504 and decreased miR-4504 expression in CRC cells. CONCLUSIONS: These findings demonstrated that lncRNA NBAT-1 suppresses OXA-resistant CRC cell growth via inhibition of miR-4504 to regulate the WWC3/LATS1/YAP axis.
other	35494481	hsa-mir-103a	Postoperative Cognitive Complications	Taken together, the data show that miR-103a-3p/VAMP1 is critical for surgery-induced microglial activation of POCD.
other	35494201	hsa-mir-135b	Infertility	The microRNA-135b is a potential biomarker to predict IVF embryo quality.
genetics_GWAS	35494025	hsa-mir-126	Carcinoma, Non-Small-Cell Lung	The Polymorphism and Expression of EGFL7 and miR-126 Are Associated With NSCLC Susceptibility.
lncRNA target	35493998	hsa-mir-1294	Osteosarcoma	qRT-PCR was used to assess the expressions of circOMA1, miR-1294, and c-Myc in osteosarcoma tissues. CONCLUSION: circOMA1 played the role of an oncogene in osteosarcoma and promoted osteosarcoma progression by mediating the miR-1294/c-Myc pathway, which might be a new target for treating osteosarcoma.
target gene	35493691	hsa-mir-384	Osteosarcoma	Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384.
lncRNA target	35493459	hsa-mir-101	Carcinoma, Hepatocellular	This study aimed to investigate the potential role of CCDC88A on malignancies and stemness by regulating VEGF via miR-101 in HCC.
genetics_knock down_promote	35493425	hsa-mir-148a	ankylosing spondylitis 1	DKK1 knockdown averted the effect of silencing miR-148a-3p in AS fibroblasts.
circRNA target	35492076	hsa-mir-543	Glioma	The circ-ASB3/miR-543/Twist1 axis was discovered to be a possible regulatory pathway in glioma, circ-ASB3 could adsorb and targeted bind to miR-543, down-regulate miR-543 expression, thus release its targeted inhibition to Twist1.
lncRNA target	35491874	hsa-mir-26a	Sepsis	Thus, our study indicated that the miR-26a-5p/IL-6 axis can alleviate sepsis-induced acute kidney injury by inhibiting renal inflammation.
lncRNA target	35491874	hsa-mir-26a	Acute Kidney Injury	Thus, our study indicated that the miR-26a-5p/IL-6 axis can alleviate sepsis-induced acute kidney injury by inhibiting renal inflammation.
other	35491723	hsa-mir-139	Carcinoma, Non-Small-Cell Lung	Conclusion: We thus conclude that circPTPRM promotes the progression of NSCLC by regulating the miR5p/SETD5 axis.
genetics_overexpression_promote	35491288	hsa-mir-188	Keloid	In addition, VEGFA overexpression also abolished the suppressive effect of miR
transcription factor target	35490917	hsa-mir-214	Carcinoma, Hepatocellular	Our data suggest that miRNA-214 regulates DNA replication by targeting MCM5/7 and has the potential to be developed into a liver cancer drug. Furthermore, the potential of miR-214 as an anticancer agent, with activity against liver cancer cells but not normal livre cells, may be of high significance.
genetics_knock down_promote	35490895	hsa-mir-374b	Glioma	What's more, overexpression of miR-374b or knockdown of SALL1 reversed the inhibitory effect of lncRNA PART1 on the proliferation, migration, and EMT of glioma cells.
other	35490865	hsa-mir-29a	Obesity	RESULTS: Here we found that mature neurons originating from the POMC lineage employ miR-29a to protect against insulin resistance obesity, hyperphagia, decreased energy expenditure and obesity. Moreover, POMC(Cre)-dependent co-deletion of Nras in mature neurons attenuated miR-29 depletion-induced obesity.
other	35490865	hsa-mir-29	Obesity	RESULTS: Here we found that mature neurons originating from the POMC lineage employ miR-29a to protect against insulin resistance obesity, hyperphagia, decreased energy expenditure and obesity. Moreover, POMC(Cre)-dependent co-deletion of Nras in mature neurons attenuated miR-29 depletion-induced obesity.
transcription factor target	35490837	hsa-mir-223	Dry Eye Syndromes	This inverse regulation between miR-223 and NLRP3 expression levels suggests that selective upregulation of miR-223 expression may be a novel option to suppress chronic inflammation in DE.
lncRNA target	35490654	hsa-mir-629	Cholangiocarcinoma	CONCLUSION: Upregulation of circ_0059961 augmented SFRP2 expression by targeting miR5p, which blocked cholangiocarcinoma tumor cell proliferation, migration, and invasion.
other	35490653	hsa-mir-23a	Pituitary Neoplasms	By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR5p to enhance the expression of RCN2 in PA.
other	35490653	hsa-mir-136	Pituitary Neoplasms	By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR5p to enhance the expression of RCN2 in PA.
other	35490305	hsa-mir-206	Glioblastoma	5p suggested the association with poor prognosis in glioblastoma patients.
genetics_overexpression_promote	35490208	hsa-mir-371b	Triple Negative Breast Neoplasms	In patients with TNBC, miR-371b-5p expression was reduced, and miR-371b-5p overexpression significantly mitigated TNBC cell growth, migration, and invasion.
lncRNA target	35490173	hsa-mir-3163	Nasopharyngeal Carcinoma	Using whole-transcript expression arrays and bioinformatic analysis, we identified scinderin (SCIN) and miR-3163 as potential downstream targets of MEX3A in NPC. In summary, our results demonstrate that MEX3A may promote NPC development and progression via the miR-3163/SCIN axis by regulating NF-kappaB signaling, thus providing a potential target for NPC treatment.
other	35490164	hsa-mir-20a	Colonic Neoplasms	5p and miR-20a-5p are independent predictors of favorable prognosis.
other	35490164	hsa-mir-17	Colonic Neoplasms	5p and miR-20a-5p are independent predictors of favorable prognosis.
other	35489420	hsa-mir-199a	Cardiovascular Diseases	Our findings point to an important role for miR-199a-3p in the early stage of cardiovascular disease.
lncRNA target	35489420	hsa-mir-199a	Inflammation	CONCLUSIONS: Our results suggested that miR-199a-3p suppressed endothelial inflammation and adhesion by targeting mTOR signaling and increasing autophagy.
other	35489290	hsa-mir-196b	Endometritis	As a result, we found miR-196b up-regulated in the endometritis tissue and the high concentration lipopolysaccharide (LPS)-stimulated bovine endometrial epithelial (BEND) cell line, but down-regulated in the low concentration.
lncRNA target	35489022	hsa-mir-142	Ovarian Neoplasms	3p and its targets gene FAM83D may be potential diagnostic and prognostic biomarkers for patients with OC.
lncRNA target	35488374	hsa-let-7f	Carcinoma, Non-Small-Cell Lung	Then the relative gene and protein expressions of let-7f and its target genes, including HMGA2, ARID3B, SMARCAD1, and FZD3, were measured in lung tissues of NSCLC patients and A549 cell line using qRT-PCR and Western blotting.
other	35488248	hsa-mir-93	Ventricular Dysfunction, Right	5p have potential value in the diagnosis of CTEPH based on the correlation between the abnormal expression of these miRNAs and echocardiographic parameters in CTEPH patients.
other	35488248	hsa-mir-17	Ventricular Dysfunction, Right	5p have potential value in the diagnosis of CTEPH based on the correlation between the abnormal expression of these miRNAs and echocardiographic parameters in CTEPH patients.
other	35488248	hsa-mir-20a	Ventricular Dysfunction, Right	5p individually (P = 0.0337 and 0.0453, respectively).
lncRNA target	35488217	hsa-mir-17	Osteochondritis Dissecans	CONCLUSION: DEX inhibits OGD/R-induced inflammation and apoptosis in PC12 cells by increasing miR
other	35488128	hsa-mir-182	Cardiotoxicity	5p could serve as a potential biomarker of structural cardiotoxicity and/or an additional endpoint to characterize cardiac injury in vitro.
other	35488128	hsa-mir-187	Cardiotoxicity	5p could serve as a potential biomarker of structural cardiotoxicity and/or an additional endpoint to characterize cardiac injury in vitro.
exosome	35488079	hsa-let-7e	Alzheimer Disease	Our study suggests that sNDEV-resident let-7e is a potential biomarker for AD diagnosis, and that AD patient-derived sNDEVs induce a neuroinflammatory response in microglia.
circulation_biomarker_diagnosis_ns	35487317	hsa-mir-21	Tetralogy of Fallot	METHODS: Serum biomarkers [metalloproteinases MMP1 and MMP9, galectin-3, micro-RNA21 (miR21)), ST2, procollagen type I carboxy-terminal propeptide (PICP), and NTproBNP] were measured in TOF patients undergoing CMR.
circulation_biomarker_diagnosis_ns	35487317	hsa-mir-21	Cardiomyopathies	METHODS: Serum biomarkers [metalloproteinases MMP1 and MMP9, galectin-3, micro-RNA21 (miR21)), ST2, procollagen type I carboxy-terminal propeptide (PICP), and NTproBNP] were measured in TOF patients undergoing CMR.
other	35487268	hsa-mir-155	Breast Neoplasms	MiR-21 and miR-155 are two significant biomarkers that act as oncomir in breast cancer.
other	35487268	hsa-mir-21	Breast Neoplasms	MiR-21 and miR-155 are two significant biomarkers that act as oncomir in breast cancer.
other	35487029	hsa-mir-129	Stomach Neoplasms	In addition, two constructed regulatory axes (include FAM66C/miR5p/7 mRNAs and SFTA1P/miR-206/FN1 or NRP1) were successfully validated by the Genomic Data Commons (GDC) GC data.
other	35487029	hsa-mir-206	Stomach Neoplasms	In addition, two constructed regulatory axes (include FAM66C/miR5p/7 mRNAs and SFTA1P/miR-206/FN1 or NRP1) were successfully validated by the Genomic Data Commons (GDC) GC data.
lncRNA target	35487027	hsa-mir-193a	Adenocarcinoma of Lung	The last rescue assays displayed that SNHG11 affecting LUAD cell malignant behaviors via regulating miR-193a-5p/SNHG11. CONCLUSION: SNHG11 regulated miR-193a-5p/Notch3 axis to activate Notch pathway, consequently facilitating the proliferation and migration in LUAD.
other	35486965	hsa-mir-1a	Pulmonary Fibrosis	Further research found that attenuation of miR-1a-3p plays an important role in TWMP-induced lung injury.
genetics_overexpression_promote	35486941	hsa-mir-873	Thyroid Neoplasms	5p on TC cells was abolished through CXCL5 overexpression.
other	35486636	hsa-mir-21	Uterine Cervical Neoplasms	Previous work has demonstrated that the expression of microRNA-21 (miR-21) is implicated in cervical cancer (CC). In this study, bioinformatic tools and meta-analysis validated that miR-21 may function as a highly sensitive and specific marker for the diagnosis of CC, which may provide a novel approach to the diagnosis and treatment of CC.
other	35486353	hsa-mir-128	Neurotoxicity Syndromes	3p.
lncRNA target	35486287	hsa-mir-128	Breast Neoplasms	3p mimics in suppressing EMT of breast cancer cell lines by regulating the TGF-beta1/SP1 axis.
other	35486213	hsa-mir-96	Glioblastoma	Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1.
other	35486213	hsa-mir-182	Glioblastoma	Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1.
other	35486213	hsa-mir-183	Glioblastoma	Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1.
genetics_GWAS	35485699	hsa-mir-34b	Carcinoma, Hepatocellular	OBJECTIVE: We aimed to demonstrate the frequency of miRNA 196a2 rs11614913 and miRNA 34 b/c rs4938723 gene polymorphisms in HCC patients and their correlation with the clinical features and laboratory findings at diagnosis. CONCLUSIONS: This study identified miR-196a2 rs11614913 CC genotype as a risk factor for HCC development while we failed to document similar relation for miR-34b/c rs4938723 polymorphism.
other	35485699	hsa-mir-196a-2	Carcinoma, Hepatocellular	RESULTS: HCC patients had significantly higher frequency of miR2a rs11614913 CC genotype when compared with cirrhotic patients (60.0 % versus 30.0 %, p=0.013).
lncRNA target	35485648	hsa-mir-876	Endometrial Neoplasms	5p/HKDC1 signal transduction axis in EC cell pyroptosis at the molecular level, which may provide an effective therapeutic target for patients with diabetes who are diagnosed with EC.
circulation_biomarker_diagnosis_ns	35485364	hsa-mir-199	Osteoarthritis	In conclusion, LINC00707 can be detected in cytoplasm and it may sponge miR
genetics_overexpression_promote	35485355	hsa-mir-2392	Carcinoma, Hepatocellular	Overexpression of miR-2392 suppressed proliferation, clonogenicity, mobility, spheroid formation and maintenance of cancer stem cells (CSC)-like characteristics in HCC cells.
exosome	35485349	hsa-mir-34a	Squamous Cell Carcinoma of Head and Neck	Here, we aimed to explore whether exosomes could be used to load microRNA-34a via co-incubation and further used to treat OSCC.
transcription factor target	35485293	hsa-mir-497	Carcinoma, Non-Small-Cell Lung	5p mimic and inhibitor were, respectively, transfected into human NSCLC cells A549 and H460, CCK-8 assay, transwell assay, and flow cytometry were used to detect the capacities of cell proliferation, invasion and apoptosis.
lncRNA target	35485286	hsa-mir-143	Fibrosis, Renal	Thus, targeting CCL20 by miR5p could alleviate renal fibrosis progression by regulating fibroblast proliferation and ECM deposition via the Smad2/3 and AKT signaling, providing a potential therapeutic target for environmental lead contamination-evoked fibrotic kidney disease.
genetics_overexpression_promote	35485281	hsa-mir-4730	Liver Neoplasms	The effects of miR4730 overexpression were examined in LC cell lines, and the target genes of miR4730 were evaluated using microarray analysis and TargetScan data.
transcription factor target	35485239	hsa-mir-1	Heart Failure	This processing is limited in HFrEF patients via the downregulation of proANP production, corin, and meprin B activities by miR-425 and miR1-3p.
transcription factor target	35485239	hsa-mir-425	Heart Failure	This processing is limited in HFrEF patients via the downregulation of proANP production, corin, and meprin B activities by miR-425 and miR1-3p.
lncRNA target	35485164	hsa-mir-125b	Carcinoma, Hepatocellular	LINC00978/microRNA-125b-5p/SOX12 axis promoted liver cancer migration, invasion, and proliferation, which could be used as a possible therapeutic target for the treatment of hepatocellular carcinoma.
circulation_biomarker_prognosis_up	35485050	hsa-mir-4429	Carcinoma, Non-Small-Cell Lung	RESULT: The expression of LINC00313 was significantly up-regulated while the expression of miR-4429 was down-regulated in NSCLC serum, tissue and cell lines.
circRNA target	35484994	hsa-mir-212	Carcinoma, Hepatocellular	circ_0003528 contributes to the development of HCC in vitro and in vivo via the miR
other	35484886	hsa-mir-29a	Hypopharyngeal Neoplasms	CONCLUSION: MiR-29a-3p and Cdc42 mRNA could be potential diagnostic biomarkers of hypopharyngeal carcinoma.
lncRNA target	35484885	hsa-mir-34a	Carcinoma, Hepatocellular	CONCLUSION: These results suggest that miR-34a-5p could inhibit the occurrence and development of HCC by targeting VEGFA.
circRNA target	35484574	hsa-mir-34c	Nasopharyngeal Carcinoma	RESULTS: CircCRIM1 and FOSL1 were upregulated in NPC cells, while miR-34c-5p was downregulated. The miR-34c-5p inhibitor notably promoted the malignant behaviour of NPC cells, while miR-34c-5p mimics exerted the opposite effect.
lncRNA target	35484565	hsa-mir-642a	Gallbladder Neoplasms	5p were identified as invasion-metastasis associated miRNAs via bioinformatics and experimental validation, and both up-regulation of miR-642a-3p and down-regulation of miR
lncRNA target	35484565	hsa-mir-145	Gallbladder Neoplasms	5p were identified as invasion-metastasis associated miRNAs via bioinformatics and experimental validation, and both up-regulation of miR-642a-3p and down-regulation of miR
other	35484551	hsa-mir-486	Pulmonary Fibrosis	To investigate the molecular mechanism of how radiation induces pulmonary fibrosis by altering miR3p content and thus inducing EMT.
exosome	35484432	hsa-mir-17	Liver Cirrhosis	CONCLUSION: hMSCs-derived exosome circCDK13 inhibited liver fibrosis by regulating the expression of MFGE8 through miR
other	35484171	hsa-mir-369	COVID-19	In conclusion, miR3p was altered in patients with mechanical ventilation requirement in comparison with COVID-19 patients without this requirement.
other	35484171	hsa-mir-369	Respiratory Distress Syndrome	In conclusion, miR3p was altered in patients with mechanical ventilation requirement in comparison with COVID-19 patients without this requirement.
genetics_GWAS	35484165	hsa-mir-26a	Upper Tract Urothelial Carcinoma	BFTC-909 UTUC cells were used to examine the effects of miR-26a-5p genetic delivery on proliferation, migration and expression of epithelial-to-mesenchymal transition (EMT) markers.
other	35484121	hsa-mir-766	Osteoarthritis	Expression of circ_0000205 was up-regulated in OA tissues and IL-1beta-induced primary chondrocytes, accompanied with miR3p down-regulation and ADAMTS5 up-regulation.
genetics_overexpression_promote	35484046	hsa-mir-34a	Colorectal Neoplasms	Overexpression of AK077216 inhibited CRA cell migration and invasion, while overexpression of miR-34a accelerated cancer cell migration and invasion and attenuated the effects of overexpression on AK077216 on cell behaviors.
genetics_overexpression_promote	35483716	hsa-mir-155	psoriasis 1	Previously, we found that MSCs from psoriatic lesions overexpress the proinflammatory microRNA, miR-155 and exhibit a decreased immunosuppressive capacity.
other	35483451	hsa-mir-27b	Hepatitis C	The miRNA miR-27b is known to regulate lipid regulatory pathways in the human liver and is also induced by the hepatitis C virus (HCV).
lncRNA target	35483343	hsa-mir-569	Pancreatic Carcinoma	These data demonstrated that microRNA-569 may exert a tumor-suppressing effect in PC and maybe a potential therapeutic target for PC patients.
genetics_knock down_promote	35483305	hsa-mir-4487	Angelman Syndrome	Also, RASA1 knockdown reversed the effects of miR-4487 inhibition on VSMCs.
other	35483234	hsa-mir-200b	Inflammation	Our findings suggest a crucial role for the miR-200b-3p/FSTL1 axis in regulating asthmatic's airway remodeling and inflammation phenotype.
other	35483234	hsa-mir-200b	Asthma	Our findings suggest a crucial role for the miR-200b-3p/FSTL1 axis in regulating asthmatic's airway remodeling and inflammation phenotype.
lncRNA target	35482822	hsa-mir-516b	Carcinoma, Non-Small-Cell Lung	Circ-OXCT1 promoted SLC1A5 expression by target binding with miR-516b-5p.Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC.
other	35482720	hsa-mir-101	Carcinoma, Hepatocellular	3p/SNX16/PAPOLG axis of the ceRNA network axis might be an important factor associated with HCC prognosis and immune infiltration.
lncRNA target	35482482	hsa-mir-378a	Acute Kidney Injury	In conclusion, lncRNA136131 protected against I/R-induced AKI progression by targeting miR-378a-3p/Rab10 and may be utilized as a novel target for AKI therapeutics.
genetics_knock down_suppress	35482475	hsa-mir-151	Diabetic Nephropathies	CONCLUSION: CircNUP98 knockdown alleviates HG-induced proliferation, fibrosis inflammation and oxidative stress in HMCs by regulating the miR3p-HMGA2 axis, which might provide a potential approach for DN therapeutics.
genetics_knock down_suppress	35482475	hsa-mir-151	Inflammation	CONCLUSION: CircNUP98 knockdown alleviates HG-induced proliferation, fibrosis inflammation and oxidative stress in HMCs by regulating the miR3p-HMGA2 axis, which might provide a potential approach for DN therapeutics.
other	35482409	hsa-mir-10b	fibrolamellar carcinoma	We identified miR-10b-5p as the top candidate pro-proliferative microRNA in FLC.
other	35482130	hsa-mir-665	Ischemic Stroke	The expression levels of hsa_circ_0010729, miR-665, and ING5 in ischemic stroke were detected by quantitative real-time polymerase chain reaction (qRT-PCR).
other	35482130	hsa-mir-665	Stroke	The expression levels of hsa_circ_0010729, miR-665, and ING5 in ischemic stroke were detected by quantitative real-time polymerase chain reaction (qRT-PCR).
lncRNA target	35481944	hsa-mir-124	Brain Injuries, Traumatic	Moreover, the combined use of BDNF and miR-124 inhibitors might lead to better outcomes in TBI than BDNF treatment alone.
lncRNA target	35481549	hsa-mir-214	Parkinson Disease	Further analyses revealed that MPP(+) inhibited cell viability; enhanced cell apoptosis, Cleaved Caspase-3 expression and Cleaved Caspase-3/GAPDH ratio; induced oxidative stress and inflammation in SH-SY5Y cells were inhibited by lncRNA BACE1-AS-siRNA transfection; and all these inhibitions were reversed by miR
lncRNA target	35481488	hsa-mir-378b	Fatty Liver	This work aimed to clarify further mechanism of CADE in improving hepatic lipid accumulation in ALD through the microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-AMPK signaling pathway. MiR-378b escalation exacerbated hepatic steatosis and inhibited CaMKK2-AMPK signaling, while miR-378b deficiency alleviated lipid accumulation and activated the CaMKK2 cascade.
lncRNA target	35481488	hsa-mir-378b	Alcoholism	This work aimed to clarify further mechanism of CADE in improving hepatic lipid accumulation in ALD through the microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-AMPK signaling pathway. MiR-378b escalation exacerbated hepatic steatosis and inhibited CaMKK2-AMPK signaling, while miR-378b deficiency alleviated lipid accumulation and activated the CaMKK2 cascade.
circRNA target	35481460	hsa-mir-1299	Squamous Cell Carcinoma of Head and Neck	Inhibition of the circGOLPH3/miR-1299/LIF axis suppressed the growth, migration, and invasion of OSCC cells. These findings indicate that the circGOLPH3/miR-1299/LIF axis promotes OSCC cell growth, migration, and invasion and that this axis is a potential therapeutic target for OSCC.
genetics_overexpression_promote	35481453	hsa-mir-381	Inflammation	MiR3p suppressed LPS-induced WI-38 cell inflammatory injury, and this effect was revoked by TRAF3 overexpression.
genetics_knock down_promote	35481447	hsa-mir-9	Stomach Neoplasms	CONCLUSIONS: These results suggested that NFIC was highly expressed in gastric cancer cells, and knockdown of NFIC suppressed the growth and mobility of gastric cancer cells; miR
transcription factor target	35481399	hsa-mir-4287	Osteoarthritis	In conclusion, miR-4287 is a critical molecule in OA development, which attenuates inflammatory response in vivo and in vitro by targeting RIPK1.
genetics_overexpression_promote	35481398	hsa-mir-374b	Iris Diseases	Overexpression of MEF2D activated the Wnt/beta-catenin pathway and attenuated the supporting effects of miR-374b-5p on renal IRI.
genetics_overexpression_promote	35481398	hsa-mir-374b	Nephritis, Interstitial	Overexpression of MEF2D activated the Wnt/beta-catenin pathway and attenuated the supporting effects of miR-374b-5p on renal IRI. CONCLUSION: Sev promotes MEF2D and activates the Wnt/beta-catenin pathway through inhibition of miR-374b-5p expression to affect renal IRI.
other	35481271	hsa-mir-135b	Ischemic Cerebral Infarction	5p/hsa-miR-3135b may regulate the REL/SOD2 pathway in ICI progression.
other	35481271	hsa-mir-518	Ischemic Cerebral Infarction	5p/hsa-miR-3135b may regulate the REL/SOD2 pathway in ICI progression.
lncRNA target	35480984	hsa-mir-760	Intervertebral Disc Degeneration	Therefore, miR-760 was found to play an important role in IDD and can be used as a promising therapeutic target for the treatment of patients with IDD.
other	35480884	hsa-mir-27b	nonpapillary renal cell carcinoma	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
other	35480884	hsa-mir-27b	Carcinoma, Hepatocellular	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
other	35480884	hsa-mir-22	Adenocarcinoma of Lung	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
other	35480884	hsa-mir-22	Carcinoma, Hepatocellular	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
other	35480884	hsa-mir-27b	Adenocarcinoma of Lung	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
other	35480884	hsa-mir-22	nonpapillary renal cell carcinoma	5p/CCNA2) by expression analysis, survival analysis, and correlation analysis.
transcription factor target	35480873	hsa-mir-874	Intervertebral Disc Degeneration	3p in IDD, thereby relieving the inhibition of ATF3 by miR
lncRNA target	35480871	hsa-mir-122	Osteoarthritis	Taken altogether, BMSC-EVs containing NEAT1 activated the Sesn2/Nrf2 axis via binding to miR
target gene	35480301	hsa-mir-107	Stomach Neoplasms	miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1.
other	35480196	hsa-mir-21	Heart Failure	MicroRNA 21 (miRNA-21) is reported to be closely associated with the development of heart failure, cardiac fibrosis and hypertrophy, which could be a promising biomarker for the early-diagnosis of heart failure.
genetics_knock down_promote	35480113	hsa-mir-124a	Melanoma	miR-124a overexpression did not inhibit tumor growth in vivo, underscoring that miR-124a specifically controls processes required for melanoma metastatic growth, such as seeding and growth post-extravasation.
other	35478990	hsa-mir-933	Carcinoma, Hepatocellular	METHODS: The level of TFAP2A-AS1 and miR-933 in HCC cell and samples were detected by qRT-PCR assay. However, miR-933 was upregulated in HCC cell lines and HBV-infected HCC samples compared with nontumor tissues, and miR-933 was negatively associated with the expression of TFAP2A-AS1 in HBV-correlated HCC samples.
circulation_biomarker_diagnosis_up	35478972	hsa-mir-146a	Atherosclerosis	The results indicated that by comparison with the HH group, the treatment with EVs(ADSCs) or EVs(MSCs) alone or in combination with Smad2/3siRNA of HH animals induced a significant decrease in the main plasma parameters and a noticeable improvement in the structure and function of the thoracic aorta and carotid artery along with a decrease in the selected molecular and cellular targets mediating their changes in atherosclerosis: 1) a decrease in expression of structural and inflammatory markers COL1A1, alpha-SMA, Cx43, VCAM-1, and MMP-2; 2) a slight infiltration of total/M1 macrophages and T-cells; 3) a reduced level of cytosolic ROS production; 4) a significant diminution in plasma concentrations of TGF-beta1 and Ang II proteins; 5) significant structural and functional improvements (thinning of the arterial wall, increase of the inner diameter, enhanced distensibility, diminished VTI and Vel, and augmented contractile and relaxation responses); 6) a reduced protein expression profile of Smad2/3, ATF-2, and NF-kBp50/p65 and a significant decrease in the expression levels of miR-21, miR-29a, miR-192, miR-200b, miR-210, and miR-146a.
other	35478963	hsa-mir-29b	Heart Diseases, Congenital	In this study, we found that miR-29b-3p expression was inversely correlated with DNMT expression in the heart tissues of patients with congenital heart disease (CHD), but whether it interacts with DNMTs in cardiomyocytes remains unknown.
genetics_knock down_promote	35478295	hsa-mir-497	Diabetic Neuropathies	Using gain- and loss-of-function assays, we analyzed the critical role of miR
genetics_GWAS	35478113	hsa-mir-145	Aortic Aneurysm, Abdominal	Literature indicates that the differentially expressed miRNA-145 in patients' serum is an essential biomarker for abdominal aortic aneurysm (AAA). However, the correlation between specific miR-145 genetic polymorphisms with AAA susceptibility is inadequately studied.
tissue_expression_ns	35478111	hsa-mir-1	Breast Neoplasms	CONCLUSION: MiR-31 was expressed at low levels in BC tissues and correlated with adverse clinical and pathological features, and poor survival.
lncRNA target	35477946	hsa-mir-21	Diabetes Mellitus, Type 2	We built a TF-miRNA-mRNA regulatory network to reveal the novel mechanism (miRPPARA-NCOA6) of dysregulated keratinocyte proliferation, differentiation, and migration in diabetic skin, which may provide new insights into the susceptibility of skin disorders in T2DM patients.
lncRNA target	35477702	hsa-mir-625	Colonic Neoplasms	It is summarized that down-regulated LINC00511 obstructs tumorigenesis of CC through restoring miR
transcription factor target	35477552	hsa-mir-146a	Diabetic Nephropathies	Mechanistically, miR-146a-5p was significantly downregulated and negatively correlated with renal injury in DN rats as determined through high-throughput RNA sequencing.
circulation_biomarker_diagnosis_up	35477546	hsa-mir-491	Atherosclerosis	5p was abnormally expressed in the plaques and serum from AS patients.
other	35477450	hsa-mir-100	Uterine Cervical Neoplasms	CircCASC15-miR-100-mTOR may influence the cervical cancer radioresistance.
circulation_biomarker_diagnosis_ns	35477045	hsa-mir-486	Pre-Eclampsia	5p was reportedly increased within exosomes derived from maternal circulation in preeclamptic pregnancy.
circRNA target	35477026	hsa-mir-20b	Diabetic Retinopathy	CONCLUSION: Circ_NNT protected ARPE-19 cells against HG-evoked apoptosis and inflammation via elevating TIMP3 through sequestering miR-320b, indicating that up-regulation of circ_NNT might contribute to the inhibition of DR process.
other	35477008	hsa-mir-1915	Hepatitis B, Chronic	TSPEAR-AS1 may bind to miR5p in HCC.
other	35476966	hsa-mir-132	Alzheimer Disease	3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(.
other	35476966	hsa-mir-146a	Alzheimer Disease	3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(.
other	35476966	hsa-mir-124	Alzheimer Disease	3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(.
other	35476966	hsa-mir-26a	Alzheimer Disease	3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(.
other	35476966	hsa-mir-181b	Alzheimer Disease	In conclusion, our study suggest that the neuroprotective effects of insulin on memory observed in AD-like rats could be partially due to the restoration of miR-132, miR-181b, and miR-125b expression in the brain.
other	35476966	hsa-mir-29a	Alzheimer Disease	3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(.
other	35476966	hsa-mir-125b	Alzheimer Disease	In conclusion, our study suggest that the neuroprotective effects of insulin on memory observed in AD-like rats could be partially due to the restoration of miR-132, miR-181b, and miR-125b expression in the brain.
transcription factor target	35476233	hsa-mir-144	Colorectal Neoplasms	The miR-144/NUDCD1/IGF1R-ERK1/2 signaling axis may be crucial in the progression of CRC.
other	35475887	hsa-mir-29a	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-155	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-23b	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-146b	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-92a	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-16	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-25	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-20b	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-223	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-221	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-338	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-146a	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
other	35475887	hsa-mir-15b	Keratitis, Herpetic	5p were significantly upregulated in patients with HEK.
transcription factor target	35475886	hsa-mir-34	Corneal Endothelium   Failure	CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.
transcription factor target	35475886	hsa-mir-34a	Corneal Endothelium   Failure	CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.
transcription factor target	35475886	hsa-mir-34b	Corneal Endothelium   Failure	CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure.
genetics_knock down_promote	35475590	hsa-mir-15b	Esophageal Squamous Cell Carcinoma	The effects of hsa_circ_0039929 knockdowns on PI3K/AKT pathways and EMT progress resembled the hsa-miR-15b-3p_R-1 overexpression.
other	35475590	hsa-mir-15b	Inflammation	All above suggested that ceRNA hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 played an important role in the inflammation and EMT caused by LMW-PAHs.
lncRNA target	35475502	hsa-mir-216b	Lung Neoplasms	In brief, LINC01578 suppresses miR-216b-5p and enhances TBL1XR1 expression, thus to promote biological functions of radiation-resistant NSCLC cells.
other	35475470	hsa-mir-96	Carcinoma, Hepatocellular	In conclusion, lncRNA PLAC2 negatively regulates the chemosensitivity of HCC cells to cisplatin, possibly by sponging miR-96 to upregulate miR-96.
lncRNA target	35475457	hsa-mir-577	Carcinoma, Non-Small-Cell Lung	In contrast, miR-577, which was a downstream target of RFX3-AS1, dramatically impeded the malignant biological behaviors of NSCLC cells. In brief, RFX3-AS1 aggravated NSCLC progression by regulating the miR-577/STAT3 axis.
other	35475453	hsa-mir-498	Urinary Bladder Neoplasms	In conclusion, our study showed that circMCTP2 regulates the expression of MDM2 by sponging miR-498 to promote the development of BC.
genetics_overexpression_promote	35475447	hsa-mir-1301	Stomach Neoplasms	In addition, miR13013p was regulated by circ_0067934, and miR13013p overexpression suppressed GC cell migration, invasion and proliferation.
genetics_knock down_suppress	35475415	hsa-mir-367	Myocardial Ischemia	circ_0000080 knockdown alleviated myocardial hypoxia injury through the miR5p/COX2 axis.
circulation_biomarker_diagnosis_ns	35475253	hsa-mir-21	Uterine Cervical Neoplasms	Using miRNA expression data in the public domain, we identified miR5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening.
circulation_biomarker_diagnosis_ns	35475253	hsa-mir-20a	Uterine Cervical Neoplasms	Using miRNA expression data in the public domain, we identified miR5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening.
lncRNA target	35475028	hsa-mir-146a	Hypertrophy	Therefore, this translational study determined the effectiveness of a hUCMSC-EVs-based approach for the treatment of LFH and revealed the critical target of miR-146a-5p and miR3p.
lncRNA target	35475028	hsa-mir-221	Hypertrophy	Therefore, this translational study determined the effectiveness of a hUCMSC-EVs-based approach for the treatment of LFH and revealed the critical target of miR-146a-5p and miR3p.
lncRNA target	35474736	hsa-mir-378	Osteoarthritis	In conclusion, miR-378 amplified OA development via repressing chondrocyte autophagy and by inhibiting BMSCs chondrogenesis, thus indicating miR-378 may be a potential therapeutic target for OA treatments.
lncRNA target	35474604	hsa-mir-1261	Adenocarcinoma of Lung	CONCLUSIONS: Circ_0072088-dependent regulation of miR-1261/PIK3CA is important for cell proliferation, migration, and invasion during the tumorigenesis and progression of LUAD, warranting the need to consider the circ_0072088/miR-1261/PIK3CA regulatory pathway as a potential therapeutic target in patients with lung adenocarcinoma.
genetics_overexpression_suppress	35474406	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	5p could repress LSCC progression, and OTX1 overexpression also eliminated this effect.
other	35474387	hsa-mir-34a	Esophageal Squamous Cell Carcinoma	In analyzable cancer types, miR-34a does not appear to be down-regulated in primary tumors relatively to normal adjacent tissues.
genetics_overexpression_promote	35474040	hsa-mir-671	Glioma	METTL3 overexpression repressed the malignant proliferation of glioma via circDLC1/miR
transcription factor target	35473892	hsa-mir-888	Carcinoma, Hepatocellular	RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs.
transcription factor target	35473892	hsa-mir-548	Carcinoma, Hepatocellular	RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs.
transcription factor target	35473892	hsa-mir-196a-1	Carcinoma, Hepatocellular	RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs.
transcription factor target	35473892	hsa-mir-548ah	Carcinoma, Hepatocellular	RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs.
other	35473752	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	5p/SP1 axis and the complex regulatory loops influence NSCLC progression.
other	35473687	hsa-mir-221	Carcinoma, Hepatocellular	Furthermore, both let7-g and miR-221 may be potential biomarkers for the outcomes of HCC patients.
other	35473680	hsa-mir-223	Acute Lung Injury	CONCLUSION: In general, our work illustrates that sevoflurane regulates the LINC00839/miR-223/NLRP3 axis to ameliorate LPS-induced ALI, which might provide a novel promising candidate for the prevention of ALI.
lncRNA target	35473552	hsa-mir-655	Adenocarcinoma of Lung	In conclusion, this study demonstrated that EBLN3P silencing inhibits bioactivity and induces apoptosis via the miR3p/Bcl-2 axis, providing a potential therapeutic target for lung adenocarcinoma.
other	35473531	hsa-mir-22	Heart Failure, Chronic	CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects.
other	35473531	hsa-mir-499	Heart Failure, Chronic	CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects.
other	35473531	hsa-mir-92a	Heart Failure, Chronic	CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects.
lncRNA target	35473519	hsa-mir-483	Osteoporosis	Furthermore, our research demonstrated that mitogen-activated protein kinase 1 (MAPK1) and SMAD family member 5 (Smad5) were direct targets of miR
transcription factor target	35473503	hsa-mir-126	Arthritis, Rheumatoid	These results reveal that curcumin protects against RA by regulating the inc00052/miR5p/PIAS2 axis through JAK2/STAT3 signaling pathway.
lncRNA target	35472619	hsa-mir-100	Pulmonary Fibrosis	The MIR100HG/miR-29a-3p/Tab1 axis could modulate TGF-beta1-induced fibrotic changes in type II alveolar epithelial cells and, thus, might be promising targets for pulmonary fibrosis therapy.
lncRNA target	35472619	hsa-mir-29a	Pulmonary Fibrosis	The MIR100HG/miR-29a-3p/Tab1 axis could modulate TGF-beta1-induced fibrotic changes in type II alveolar epithelial cells and, thus, might be promising targets for pulmonary fibrosis therapy.
genetics_overexpression_promote	35471684	hsa-mir-1290	Triple Negative Breast Neoplasms	Moreover, the involvement of the miR-1290/NLRP3 axis in TNBC radioresistance was analyzed by experiments with a miR-1290 mimic and NLRP3 overexpression.
circulation_biomarker_diagnosis_up	35470961	hsa-mir-384	Alzheimer Disease	RESULTS: The Abeta42, Abeta(42/40) , Tau, P-T181-tau, and miR-384 levels in NCAM single-labeled and NCAM/ABCA1 double-labeled exosomes of the aMCI and AD groups were significantly higher than those of the SCD, control, and vascular dementia (VaD) groups (all p < 0.05). The plasma NCAM/ABCA1 dual-labeled exosomal Abeta(42/40) and miR-384 had potential advantages in the diagnosis of SCD.
lncRNA target	35470783	hsa-mir-21	Breast Neoplasms	The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer.
lncRNA target	35470783	hsa-mir-125a	Breast Neoplasms	The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer.
lncRNA target	35470783	hsa-mir-20b	Breast Neoplasms	The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer.
other	35470728	hsa-mir-139	Asthma	5p/TRIM8 axis, hinting at an underlying therapeutic strategy for asthma.
other	35469231	hsa-mir-139	Intracranial Aneurysm	Despite further research being needed to determine the exact functions of miR5p in the formation of CA, our new findings contribute to a comprehensive understanding of the treatment mechanism of IA.
exosome	35468879	hsa-mir-21	Femur Head Necrosis	5p shuttled by hucMSC-Exos, in promoting angiogenesis and osteogenesis, which may be a potential therapeutic target for ONFH.
lncRNA target	35468741	hsa-mir-375	Colorectal Neoplasms	CONCLUSIONS: LINC00022 may up-regulate FOXF1 expression via competitively binding miR3p, thereby promoting the development of CRC.
lncRNA target	35468721	hsa-mir-429	Carcinoma, Hepatocellular	MiR-429 was validated to be the target of MAPKAPK5-AS1, and miR-429 inhibitors could partially offset the effects of knocking down MAPKAPK5-AS1 on HCC cells.
transcription factor target	35468468	hsa-mir-145	Lupus Nephritis	CONCLUSION: Our data reveals that miR-145 regulates LN progression via CSF1 mediated JAK/STAT signaling pathway, and miR-145 may be a new therapeutic target for LN treatment.
other	35468339	hsa-mir-130a	Prostatic Neoplasms	Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients. Notably, we found that miR-301a and miR-454 were significantly upregulated whereas miR-130a were downregulated in cancerous tissues of prostate cancer patients compared to adjacent healthy tissue samples.
other	35468339	hsa-mir-454	Prostatic Neoplasms	Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients. Notably, we found that miR-301a and miR-454 were significantly upregulated whereas miR-130a were downregulated in cancerous tissues of prostate cancer patients compared to adjacent healthy tissue samples.
genetics_knock down_promote	35468304	hsa-mir-4731	Stomach Neoplasms	5p inhibition and HOXC6 overexpression could reverse the biological behavior of GC cells induced by LINC01857 knockdown.
transcription factor target	35468097	hsa-mir-181a	Esophageal Squamous Cell Carcinoma	In short, repressed ERK-MMP pathway mediated by miR-181a-5p can inhibit cell migration, invasion and proliferation by targeting MAP2K1 (MEK1) in ESCC.
lncRNA target	35468096	hsa-mir-206	Depression	These miRNAs can activate or inhibit the T cell receptor signal pathway, JAK-STAT and other signal pathways, govern immune-inflammatory response, neuronal remodeling, and mediate the onset and development of MMD Conclusions: The results of a thorough bioinformatics investigation of miRNAs and mRNAs in MDD showed that miR3P and miR-206 might be effective biomarkers and possible therapeutic targets for the treatment of MDD via nerve-immunity interaction.
lncRNA target	35468096	hsa-mir-338	Depression	These miRNAs can activate or inhibit the T cell receptor signal pathway, JAK-STAT and other signal pathways, govern immune-inflammatory response, neuronal remodeling, and mediate the onset and development of MMD Conclusions: The results of a thorough bioinformatics investigation of miRNAs and mRNAs in MDD showed that miR3P and miR-206 might be effective biomarkers and possible therapeutic targets for the treatment of MDD via nerve-immunity interaction.
exosome	35467477	hsa-mir-524	Carcinoma, Non-Small-Cell Lung	5p-METTL3/SOX2 axis in A549/DDP and H1299/DDP cells.Exosomal circVMP1 transmits the malignant properties and DDP resistance to DDP-sensitive cells.
circulation_biomarker_diagnosis_up	35467432	hsa-mir-222	Carcinoma, Hepatocellular	AIMS: This study was conducted to assess the ability of the serum expression of exosomal miR-18a and miR-222 to differentiate and diagnose patients with HCC, patients with liver cirrhosis, and healthy controls.
other	35467432	hsa-mir-18a	Carcinoma, Hepatocellular	Moreover, miR-18a and miR-222 could be useful in identifying liver injuries, including fibrosis and cirrhosis.
lncRNA target	35467292	hsa-mir-106a	Vascular Calcification	CircHIPK3 regulated osteogenic and cartilage differentiation of VSMC via miR-106a-5p/MFN2 axis, indicating a target for treating vascular calcification.
genetics_GWAS	35467177	hsa-mir-145	Urinary Bladder Neoplasms	At the end, blood samples and bladder tissues were collected and checked for the presence of malignancy, markers of angiogenesis (VEGF relative gene expression), inflammation (IL-6), proliferation (KI-67 expressions), oxidative stress (serum MDA and serum SOD) and epigenetic control (miRNA-145 level).
genetics_overexpression_promote	35467063	hsa-mir-224	Squamous Cell Carcinoma of Head and Neck	Overexpression of MALAT1 and KDM2A or miR
lncRNA target	35467005	hsa-mir-486	Adenocarcinoma of Lung	5p suppressed cell malignant progression in LUAD by targeting SAPCD2, suggesting that the two may be targets for LUAD treatment.
genetics_knock down_suppress	35466471	hsa-mir-103a	Carcinoma, Renal Cell	In addition, SNHG1 knockdown and miR-103a overexpression significantly inhibited progression of RCC.
lncRNA target	35466323	hsa-mir-196	Cholangiocarcinoma	5p inhibition notably suppressed cell proliferation as well as metastasis in CCA cell line HuCCT1.
lncRNA target	35466322	hsa-mir-135a	Osteosarcoma	High expression levels of miR-135a promoted transplanted tumor development in vivo and the proliferation and migration of OS cells by targeting SMAD2.
genetics_knock down_suppress	35466320	hsa-mir-145	Colorectal Neoplasms	5p reverted the effects of CBR3-AS1 knockdown on CRC cells.
lncRNA target	35466317	hsa-mir-513	Carcinoma, Hepatocellular	qRT-PCR experiments confirmed that olaparib could increase PD-L1 expression through inhibiting miR-513 in HCC cells. CONCLUSION: The present study reveals that inhibition of PARP potentiates immune checkpoint therapy through the miR-513/PD-L1 pathway in HCC and the combination of PARP inhibitor olaparib and anti-PD1 is beneficial to HCC therapy.
genetics_knock down_promote	35466313	hsa-mir-144	Stomach Neoplasms	3p inhibition or EZH2 restoration largely blocked the effects of circKIF4A knockdown on the malignant behaviors of GC cells.
other	35465986	hsa-mir-424	Enzootic Bovine Leukosis	5p in milk sEV could be one of the characteristic trends in cattle that are high risk for BLV transmission.
genetics_overexpression_promote	35465967	hsa-mir-520	Stomach Neoplasms	3p overexpression on the proliferation of GC cells.
genetics_overexpression_suppress	35465835	hsa-mir-23a	Uterine Cervical Neoplasms	In addition, SLC7A11 rescued the effect of miR-23a-5p overexpression on progression of CC cells.
lncRNA target	35465051	hsa-mir-200	Graft Occlusion, Vascular	Our study unraveled the substantial contribution of miRNAs in regulating the SMC transcriptome and identified the miR-200 cluster as a pro-quiescence mechanism and a potential inhibitor of vascular restenosis.
lncRNA target	35465017	hsa-mir-552	Ovarian Neoplasms, High-Grade Serous	Collectively, these findings suggest that Linc00261, a mediator of EMT progression, can target oncogenic miR-552, elevating ATG10 expression, to prevent high-grade serous ovarian cancer tumorigenesis and may serve as a potential novel therapeutic target.
other	35464137	hsa-mir-122	Liver Injury	MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet.
genetics_overexpression_promote	35464065	hsa-mir-22	Diabetes Mellitus, Type 1	By RNA sequencing, we noticed that Tumor necrosis factor (TNF) signaling was the only pathway that was significantly and oppositely altered in these two experimental sets, with it upregulated in DM1 and inhibited by miR-322/-503 overexpression.
circulation_biomarker_diagnosis_ns	35463986	hsa-mir-34a	Coronary Occlusion	OBJECTIVE: By detecting the levels of external counterpulsation combined with exercise therapy on the levels of moesin, angiopoietin-like protein2 (Angptl 2), angiopoietin-like protein (Angptl 3), hypoxia inducible factor-1alpha (HIF-1alpha), and RNA-34a (miR-34a) in patients with coronary artery occlusive disease, the effect of external counterpulsation combined with exercise therapy on the establishment of occluded coronary collateral circulation was studied.
transcription factor target	35463769	hsa-mir-3925	Dmd-Associated Dilated Cardiomyopathy	Furthermore, the higher OGDHL protein expression, except the change of PLA2G2, was also found in DCM hearts, and its mRNA expression was negatively correlated with myocardial Masson's scores (r = -0.84, P = 0.009) and left ventricular end-diastolic diameter (LVEDd; r = -0.82, P = 0.014), which might be regulated by miR5p through further bioinformatics prediction and qRT-PCR verification.
circulation_biomarker_diagnosis_up	35463692	hsa-mir-103a	Parkinson Disease	To explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (BDNF), and serum miR-103a and miR-30b and inflammatory factors in rats with Parkinson's disease. Pramipexole may up-regulate the expressions of BDNF, miR-103a and miR-30b to inhibit the apoptosis and inflammation in Parkinson's disease model rats.
lncRNA target	35463310	hsa-mir-490	Nasopharyngeal Carcinoma	3p, which may contribute to new prognostic markers and promising therapeutic targets.
other	35463276	hsa-mir-296	Glioma	We also identify the lncRNA/miR5p/GSDMD regulatory axis as an important player in glioma progression.
other	35463266	hsa-mir-149	Pulmonary Disease, Chronic Obstructive	OBJECTIVE: To study the mechanism of chronic obstructive pulmonary disease (COPD) in diagnosing alveolar factors and analyze the effect of miR3p on alveolar inflammatory factors and the expression of surfactant protein D (SP-D) and SP-A on the lung surface mediated by Wnt pathway.
transcription factor target	35463073	hsa-mir-3912	Osteosarcoma	CONCLUSION: Our data clearly indicate that GN is a candidate drug for OS treatment, and GN plays its role through miR3p/ANGPTL4 in OS.
circulation_biomarker_diagnosis_down	35462367	hsa-mir-654	Coronary Artery Disease	5p was significantly downregulated in the plasma of CAD patients and tumor necrosis factor-a/platelet-derived growth factor (PDGF)-BB-stimulated VSMCs.
other	35462331	hsa-mir-9	Leukemia, Myeloid, Acute	Furthermore, we report a direct linkage of miR-9 to ABCB1 efflux activity in the PBMC and propose miR-9 as a useful prognostic marker in AML. Moreover, we suggest miR-9 as a predictive ABCB1-related biomarker that could be immensely helpful in identifying ABCB1-resistant AML phenotype to enable optimized therapeutic regimen and improved treatment outcome.
tissue_expression_ns	35462240	hsa-mir-181a	Atherosclerosis	Endothelial miR-181a2b2 deficiency regulates multiple key pathways related to endothelial inflammation, cell adhesion, cell cycle, and immune response involved in the development of atherosclerosis.
genetics_GWAS	35462240	hsa-mir-181b	Atherosclerosis	The aim of this study is to examine the role of genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis.
other	35462006	hsa-mir-200c	Acquired Immunodeficiency Syndrome	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-200c	Depressive Disorder, Major	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-429	Depressive Disorder, Major	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-183	Depressive Disorder, Major	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-183	Acquired Immunodeficiency Syndrome	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-183	Osteoarthropathy, Primary Hypertrophic	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-429	Osteoarthropathy, Primary Hypertrophic	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-200c	Osteoarthropathy, Primary Hypertrophic	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35462006	hsa-mir-429	Acquired Immunodeficiency Syndrome	3p, known to be associated with MDD and CI; all were normalized by PDDC.
other	35461401	hsa-mir-146a	developmental and epileptic encephalopathy	3p can be used as epileptic encephalopathy biomarkers.
other	35461401	hsa-mir-138	developmental and epileptic encephalopathy	3p can be used as epileptic encephalopathy biomarkers.
other	35461401	hsa-mir-187	developmental and epileptic encephalopathy	3p can be used as epileptic encephalopathy biomarkers.
circulation_biomarker_diagnosis_ns	35461393	hsa-mir-380	Diabetic Retinopathy	3p expression increased 2.6-fold in the serum of DR patients.
circulation_biomarker_diagnosis_ns	35461372	hsa-let-7b	Carcinoma, Non-Small-Cell Lung	These findings suggest that the expression levels of circulating hsa-miR
exosome	35461336	hsa-mir-17	Colorectal Neoplasms	Upregulated CRCSC-exosomal miR
lncRNA target	35461324	hsa-mir-601	Osteosarcoma	The results of in vitro and in vivo assay revealed that elevated miR-601 inhibited the proliferative, migratory and invasive capacities in OS cells.
transcription factor target	35461040	hsa-mir-377	Carcinoma, Hepatocellular	3p facilitates the proliferation and suppresses the cell cycle arrest and apoptosis in HCC by affecting transcription factor EGR1-mediated p53 activation.
other	35461010	hsa-mir-200a	Autoimmune Diseases	Previous research has demonstrated that microRNA-200a regulates cell apoptosis, tumor progression, and autoimmune disease.
genetics_overexpression_promote	35460876	hsa-mir-1263	Arthritis, Rheumatoid	Functionally, overexpression of miR-1263 suppressed the development of HFLS-RA by blocking the NF-kappaB pathway, and this phenomenon was reversed by the upregulation of REL.
exosome	35460835	hsa-mir-124	Breast Neoplasms	3p, the local miRNA sponged by the exosomal circHIPK3.circHIPK3 enclosed in the BC cell-derived exosomes enhanced MTDH expression in the endothelial cell by sponging miR
other	35460694	hsa-mir-200c	Fatty Liver, Alcoholic	Taken together, these results suggest that miR-200c contributes to the modulation of lipid homeostasis in AFL disease by cooperatively regulating Hnf1b and ApoO functions.
genetics_knock down_promote	35460538	hsa-mir-515	Nasopharyngeal Carcinoma	CONCLUSION: Circ_0004788 knockdown restrained the progression of NPC via the miR
lncRNA target	35460500	hsa-mir-128	Glioma	CONCLUSION: The overall results indicated that LINC02381 exerts its oncogenic effect in glioma cells through sponging miR-128 and miR-150 to upregulate the IGF1R signaling pathway. Our results introduce LINC02381 and miR-128, and miR-150 as potential prognosis and therapy targets for the treatment of glioma.
lncRNA target	35460500	hsa-mir-150	Glioma	CONCLUSION: The overall results indicated that LINC02381 exerts its oncogenic effect in glioma cells through sponging miR-128 and miR-150 to upregulate the IGF1R signaling pathway. Our results introduce LINC02381 and miR-128, and miR-150 as potential prognosis and therapy targets for the treatment of glioma.
exosome	35460420	hsa-mir-431	Colorectal Neoplasms	5p serves as a prognostic biomarker in CRC, and hUCMSC-Exos transfer of miR
genetics_overexpression_promote	35460386	hsa-mir-1323	Carcinoma, Non-Small-Cell Lung	Circ_0030998 overexpression-mediated effects on the DDP resistance and malignant properties of NSCLC cells were largely based on its negative regulation of miR-1323.
lncRNA target	35460325	hsa-mir-708	Ventricular Premature Complexes	5p has a crucial effect on VC via targeting Pit-1 and inhibiting Wnt8b/beta-catenin pathway, it may serve as a new target for VC treatment.
other	35460089	hsa-mir-223	Ataxia Telangiectasia	The present results discovered that a combination of AT DE intervention improves the miR-33 and miR-223 in the liver of obese rats.
circulation_biomarker_diagnosis_ns	35460089	hsa-mir-3	Obesity	These findings show that long-term AT combined with the intake of DE may improve the plasma levels of Apo B, and TC and HDL-C levels in the liver, which is probably due to AT and DE positive effects on miR-33 and miR-223 in the liver of obese rats.
circulation_biomarker_diagnosis_ns	35460089	hsa-mir-223	Obesity	These findings show that long-term AT combined with the intake of DE may improve the plasma levels of Apo B, and TC and HDL-C levels in the liver, which is probably due to AT and DE positive effects on miR-33 and miR-223 in the liver of obese rats.
other	35460089	hsa-mir-3	Ataxia Telangiectasia	The liver expression of miR-33 was lower in the AT, DE, AT DE, and NC groups compared with the OC group. The present results discovered that a combination of AT DE intervention improves the miR-33 and miR-223 in the liver of obese rats.
lncRNA target	35459765	hsa-mir-27b	Fetal Macrosomia	MiR-27b was probably involved in non-GDM macrosomia through negative regulation of PPARalpha/gamma protein.
lncRNA target	35459441	hsa-mir-513a	Adenocarcinoma of Lung	miR-513a-3p has been found to sensitize human lung adenocarcinoma cells to chemotherapy by targeting glutathione S-transferase P1 (GSTP1).
exosome	35459211	hsa-mir-124	Reperfusion Injury	miR3p in HM-exos downregulates Steap3 expression to inhibit ferroptosis, thereby attenuating graft IRI, which might be a promising strategy to treat IRI in steatotic grafts.
transcription factor target	35459188	hsa-mir-4701	Arthritis, Rheumatoid	5p is evidenced to be participated in synovial invasion and joint destruction.
transcription factor target	35459188	hsa-mir-4701	Osteoarthritis	5p could alleviate the inflammatory injury of IL-1beta-treated CHON-001 cells via down-regulating HMGA1, indicating that miRNA
circRNA target	35459186	hsa-mir-615	Carcinoma, Pancreatic Ductal	CONCLUSION: Circ-MTHFD1L maintains PDAC gemcitabine resistance through the miR3p/RPN6 signal axis.
other	35458670	hsa-mir-16	Diabetes Mellitus, Type 2	Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients.
other	35458670	hsa-mir-16	Diabetes Mellitus	Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients.
other	35458670	hsa-mir-208b	Diabetes Mellitus	5p (1.0006; 1.00011.0012, p = 0.016), miR-208b-3p (2.82; 0.918.71, p = 0.071), and hypertension (0.27, 0.080.95, p = 0.042) were associated with MACCE.
other	35458670	hsa-mir-134	Diabetes Mellitus, Type 2	Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients.
other	35458670	hsa-mir-134	Diabetes Mellitus	Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients.
other	35458670	hsa-mir-208b	Diabetes Mellitus, Type 2	5p (1.0006; 1.00011.0012, p = 0.016), miR-208b-3p (2.82; 0.918.71, p = 0.071), and hypertension (0.27, 0.080.95, p = 0.042) were associated with MACCE.
other	35458112	hsa-mir-451	Obesity	These results may provide insights into the functions of miR-451 and food-derived phytoestrogens in ameliorating and preventing gluconeogenesis-related diseases.
transcription factor target	35457185	hsa-mir-200b	Esophageal Squamous Cell Carcinoma	Conversely, the suppression of miR-200b and miR-200c in ESCC cells attenuated E-cadherin, and that converted cells to mesenchymal type by elevating N-cadherin expression, and impaired cell sensitivity to CCRT treatment. Conclusively, miR-200b and miR-200c can modulate the conversion of epithelial-mesenchymal phenotype in ESCC, and thereby altering the response of cells to CCRT treatment.
transcription factor target	35457185	hsa-mir-200c	Esophageal Squamous Cell Carcinoma	Conversely, the suppression of miR-200b and miR-200c in ESCC cells attenuated E-cadherin, and that converted cells to mesenchymal type by elevating N-cadherin expression, and impaired cell sensitivity to CCRT treatment. Conclusively, miR-200b and miR-200c can modulate the conversion of epithelial-mesenchymal phenotype in ESCC, and thereby altering the response of cells to CCRT treatment.
circulation_biomarker_diagnosis_ns	35457094	hsa-mir-222	Diabetes, Gestational	3p are two circulating biomarkers that could improve GDM classification power and act in the context of the molecular events leading to the metabolic alterations observed in GDM.
circulation_biomarker_diagnosis_ns	35457094	hsa-mir-409	Diabetes, Gestational	3p are two circulating biomarkers that could improve GDM classification power and act in the context of the molecular events leading to the metabolic alterations observed in GDM.
transcription factor target	35457012	hsa-mir-614	Prostatic Neoplasms	5p exerts a significant inhibitory effect on cell viability and colony formation and induces sub-G1 cell cycle arrest and apoptosis in human prostate cancer cells.
other	35456995	hsa-mir-133a	Heart Diseases	Despite additional unexplored factors being possible contributors to this negative feedback mechanism, miR-133a might also be considered as a potential therapeutic tool for the diagnosis, therapy and prognosis of cardiac diseases.
lncRNA target	35456497	hsa-mir-200	Breast Neoplasms	Breast cancer cells with mesenchymal characteristics, particularly the claudin-low subtype, express extremely low levels of miR-200s. This is the first study to implicate MXRA8 in human breast cancer, and our data suggests that miR-200s inhibit growth and metastasis of claudin-low mammary tumor cells in vivo through downregulating MXRA8 expression.
genetics_GWAS	35456485	hsa-mir-129	Heart Failure	5p overexpression was found to significantly inhibit the expression of hair follicle development-related genes (HFDRGs), such as BCL2, WNT2, CCND1, and LEF1 (p &lt; 0.01), and promoted the expression of SFRP2, TGF-1, and FGF2 (p &lt; 0.01), which was the same as the knockdown of HOXC13.
genetics_GWAS	35456485	hsa-mir-129	Hair Diseases	These results will help to understand the role and mechanism of miR5p in the periodic development of HF, and will provide support for subsequent studies, not only providing a theoretical basis for genetically improving the quality of hair in animals in the future, but also a new theory and method for diagnosing and treating hair loss in humans.
transcription factor target	35456471	hsa-mir-132	Telangiectasia, Hereditary Hemorrhagic	3p, in HHT MACs was identified.
transcription factor target	35456441	hsa-mir-24	Endomyocardial Fibrosis	In brief, we revealed that miR3p promoted proliferation but inhibited differentiation of intramuscular preadipocytes by blocking ANXA6 expression, thus dominating IMF deposition in broilers.
other	35456428	hsa-mir-27a	Prostatic Neoplasms	Conversely, in the CaP cases, higher levels of miR 27a-3p and AR were observed.
other	35456428	hsa-mir-124	Prostatic Neoplasms	RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples.
other	35456428	hsa-mir-488	Prostatic Neoplasms	RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples.
other	35456428	hsa-mir-130a	Prostatic Neoplasms	RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples.
other	35456388	hsa-mir-671	Exfoliation Syndrome	5p expression in PEX are needed.
other	35456388	hsa-mir-1307	Exfoliation Syndrome	5p expression in PEX are needed.
other	35456388	hsa-mir-374a	Exfoliation Syndrome	5p expression in PEX are needed.
other	35456388	hsa-mir-708	Exfoliation Syndrome	5p expression in PEX are needed.
other	35455956	hsa-mir-182	Fibromyalgia	qRT-PCR validated miR5p upregulation, distinguishing FMS patients from healthy controls.
other	35455702	hsa-mir-196a-2	Polycystic Ovary Syndrome	The distribution of Kruppel-like factor 14 rs972283 G > A, miR-27a rs895819 A > G, and miR-196a-2 rs11614913 C > T genotypes analyzed within PCOS patients and healthy controls in the considered population was significant (p < 0.05), except for miR-423 rs6505162 C > A genotypes (p > 0.05). Moreover, allele A of KLF-14 and allele T of miR-196a2 were strongly associated with PCOS susceptibility in the considered population.
other	35455702	hsa-mir-196a	Polycystic Ovary Syndrome	The distribution of Kruppel-like factor 14 rs972283 G > A, miR-27a rs895819 A > G, and miR-196a-2 rs11614913 C > T genotypes analyzed within PCOS patients and healthy controls in the considered population was significant (p < 0.05), except for miR-423 rs6505162 C > A genotypes (p > 0.05). Moreover, allele A of KLF-14 and allele T of miR-196a2 were strongly associated with PCOS susceptibility in the considered population.
circulation_biomarker_diagnosis_up	35455065	hsa-mir-212	COVID-19	This study aims to investigate the serum level of sACE2 and 4 miRNAs (miR-421, miR-3909, miR
other	35455042	hsa-mir-138	Atherosclerosis	Altogether, this study demonstrated that the miRAPT1 axis may be partially responsible for atherosclerosis development by regulating the H-Ras-MAPK signaling pathway and hBP transportation.
circulation_biomarker_diagnosis_up	35454929	hsa-let-7i	Hepatitis C	After Cox's regression model was used to adjust for age, sex, HCV genotype, and FIB-4 >/= 3.25, patients with CHC with let-7i median >/= -1.696 (adjusted hazard ratio [aHR] = 0.31, 95% CI: 0.08-0.94, p = 0.0372) in the sustained virologic response (SVR) groups and >/=-1.696 (aHR = 0.09, 95% CI: 0.08-0.94, p = 0.0022) in the non-SVR group were less likely to develop HCC. Thus, circulating let-7i can be used for early CHC surveillance in patients with HCC risk after antiviral treatment.
circulation_biomarker_diagnosis_up	35454929	hsa-let-7i	Carcinoma, Hepatocellular	After Cox's regression model was used to adjust for age, sex, HCV genotype, and FIB-4 >/= 3.25, patients with CHC with let-7i median >/= -1.696 (adjusted hazard ratio [aHR] = 0.31, 95% CI: 0.08-0.94, p = 0.0372) in the sustained virologic response (SVR) groups and >/=-1.696 (aHR = 0.09, 95% CI: 0.08-0.94, p = 0.0022) in the non-SVR group were less likely to develop HCC. Thus, circulating let-7i can be used for early CHC surveillance in patients with HCC risk after antiviral treatment.
target gene	35454815	hsa-mir-34a	Neuroblastoma	Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of Neuroblastoma via Novel miR-34a/tRiMetF31/PFKFB3 Axis.
genetics_overexpression_promote	35454146	hsa-mir-107	Diabetes Mellitus, Type 2	Finally, the overexpression of miR-107 was associated with higher HOMA-IR in the diabetic group (r = 0.373, p = 0.035).
circulation_biomarker_diagnosis_up	35453838	hsa-mir-34a	Breast Neoplasms	Conclusions: Circulating serum miR-155, miR-373, miR-10b, and miR-34a are potential biomarkers for early BC detection in Egyptian patients and their combination shows high sensitivity and specificity.
lncRNA target	35453669	hsa-mir-195	Inflammatory Bowel Diseases	Our data support a previously unreported role of miR5p in intestinal tight junctions' regulation and suggest a potential pharmacological target for new therapeutic approaches in IBD.
lncRNA target	35453643	hsa-mir-92b	ankylosing spondylitis 1	In PsA, a unique regulatory pathway exists through miR-26a
lncRNA target	35453643	hsa-mir-223	ankylosing spondylitis 1	In PsA, a unique regulatory pathway exists through miR-26a
lncRNA target	35453643	hsa-mir-92b	Arthritis, Psoriatic	In PsA, a unique regulatory pathway exists through miR-26a
lncRNA target	35453643	hsa-mir-223	Arthritis, Psoriatic	In PsA, a unique regulatory pathway exists through miR-26a
lncRNA target	35453643	hsa-mir-223	Arthritis, Rheumatoid	In PsA, a unique regulatory pathway exists through miR-26a
other	35453643	hsa-mir-10b	ankylosing spondylitis 1	3p in AS, and let-7d-5p in RA.
other	35453643	hsa-mir-10b	Arthritis, Psoriatic	3p in AS, and let-7d-5p in RA.
other	35453643	hsa-mir-10b	Arthritis, Rheumatoid	3p in AS, and let-7d-5p in RA.
lncRNA target	35453643	hsa-mir-92b	Arthritis, Rheumatoid	In PsA, a unique regulatory pathway exists through miR-26a
other	35453608	hsa-mir-371a	COVID-19	The upregulation of the miR-371a-3p is responsible for the downregulation of the AR in SARS-CoVpositive patients, resulting in decreased spermatogenesis.
lncRNA target	35453537	hsa-mir-665	Optic Atrophy, Hereditary, Leber	Predicted by bioinformatics approaches, hsa_circ_0087207 acts as the sponge of miR-665 to induce the expression of a variety of apoptosis-related genes in LHON patient iPSC-derived RGCs. Targeting the hsa_circ_0087207/miR-665 axis might hold therapeutic promises for the treatment of LHON.
other	35452958	hsa-mir-147	Myocardial Infarction	A recent report indicates that miR-147 expression is decreased in the myocardium of a myocardial infarction model, suggesting a potential role of this miRNA in DOX-induced cardiomyocyte toxicity.
genetics_overexpression_promote	35452863	hsa-mir-142	Porcine Reproductive and Respiratory Syndrome	Subsequently, we showed that overexpression of miR
circRNA target	35452749	hsa-mir-124	Reperfusion Injury, Cerebral Ischemia	This is the first time that circRNAs have been shown to be closely related to brain IR injury and RIPostC and suggests that targeting the circRNA_0002286-miR3p-VLCAD pathway might attenuate brain IR injury.
circulation_biomarker_diagnosis_ns	35452574	hsa-mir-218	Obesity	5p levels are significantly (p<0.05) increased in accordance with serum leptin levels in obese children.
lncRNA target	35452510	hsa-mir-34a	Necrobiotic Disorders	MiR-34a (a Bcl-2 inhibitor), G-CSF (a miR-34a inhibitor), MAPK activation (pro-cell death), and citrulline (a biomarker of entroepithelial proliferation), active caspase-3 (a biomarker of apoptosis) and caspase-1 activated gasdermin D (a pyroptosis biomarker) were measured in the sternum, femur BM and ileum.
lncRNA target	35452205	hsa-mir-15b	Adenocarcinoma of Lung	In conclusion, LINC00342 promotes metastasis of lung adenocarcinoma through inducing TPBG targeted by miR-15b.
lncRNA target	35452205	hsa-mir-15	Adenocarcinoma of Lung	In conclusion, LINC00342 promotes metastasis of lung adenocarcinoma through inducing TPBG targeted by miR-15b.
exosome	35452193	hsa-mir-503	Myocardial Infarction, Acute	EV-encapsulated miR-503, which is enriched during the early phase of AMI, is a critical molecule that mediates myocardial injury.
circulation_biomarker_diagnosis_down	35451884	hsa-mir-21	Endometriosis	Cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a potential target of miR5p, is downregulated in endometriotic specimens.
circulation_biomarker_diagnosis_up	35451808	hsa-mir-214	Cognition Disorders	RESULTS: We identified 76 differentially expressed plasma exosomal miRNAs in PND patients after surgery (P<0.05, mid R:log2FCmid R:>0.58), including the upregulated hsa-miR
genetics_overexpression_promote	35451652	hsa-mir-584	Lung Neoplasms	3p could reverse the repressive effects of reduced LINC00174 on the development of LC cells; while RPS24 overexpression inverted the repressive effects of miR
lncRNA target	35451651	hsa-mir-222	Ovarian Neoplasms	3p inhibited the migration and proliferation of OC cells.
lncRNA target	35451584	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	CONCLUSION: LINC00174, as a competitive endogenous RNA, elevates LATS2 expression by adsorbing miR5p, thereby inhibiting the viability and migration of NSCLC cells, and promoting apoptosis.
target gene	35451580	hsa-mir-205	Liver Neoplasms	miR-205 Reverses MDR-1 Mediated Doxorubicin Resistance via PTEN in Human Liver Cancer HepG2 Cells.
lncRNA target	35451558	hsa-mir-450a	Breast Neoplasms	We revealed that miR-450a mimic transfected breast cancer cells (T47D and BT474) exhibited attenuated capacities of proliferation, migration, and invasion in vitro, and miR-450a suppressed T47D cell growth in a xenograft tumor model.
lncRNA target	35451420	hsa-mir-10b	Ischemic Stroke	Thus, lncRNA NEAT1 inhibited inflammasome activation by NLRP3 in microglia via the NEAT1/ miR10b5p/BCL6/NLRP3 regulatory axis, which alleviated deleterious outcomes of ischemic stroke.
other	35450554	hsa-mir-212	Diabetes Mellitus, Type 2	Several microRNAs, including miR3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood.
other	35449863	hsa-mir-129	Encephalomyelitis, Autoimmune, Experimental	As a result, we may assume the autoimmune disease illness has progressed once concentrations of HMGB1, TLR4/NF-kappaB, and miR5p have decreased.
transcription factor target	35449817	hsa-mir-584	Inflammation	TargetScan software analysis showed that miR5p can bind to the 3' noncoding region of TLR4, which is involved in the occurrence and development of ALI, thereby affecting the inflammatory pathway and inflammation development.
transcription factor target	35449817	hsa-mir-584	Acute Lung Injury	TargetScan software analysis showed that miR
other	35449729	hsa-mir-181a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	After validating in international cohorts, the joint quantification of miR-181a and VEGF-A might provide a novel tool to precisely diagnose CNS involvement and adjust CNS-directed therapy in pALL.
genetics_overexpression_promote	35449370	hsa-mir-561	Fibrosis, Renal	Knocking down circACTR2 and overexpressing miR-561 may, thus, benefit the treatment of renal fibrosis.
genetics_knock down_promote	35449340	hsa-mir-106a	Ovarian Neoplasms	OC cells were treated with SKOV3-EVs or SKOV3-EVs overexpressing miR-106a-5p to detect the proliferation, migration, and invasion.
circRNA target	35449053	hsa-mir-6795	Diabetes, Gestational	CONCLUSION: circMAP3K4 could suppress the insulin-PI3K/Akt signaling pathway via miR
other	35448502	hsa-mir-277	Colorectal Neoplasms	We also investigated miR-277 effects on ISC in a benign and our newly developed CRISPR-Cas9-based colorectal cancer model and found effects on ISC survival, which as a consequence affects tumor growth, further underlining the importance of FAO in a pathological context.
other	35447890	hsa-mir-532	Pulmonary Disease, Chronic Obstructive	5p and miR-451b) replicated.
other	35447890	hsa-mir-296	Asthma	5p and miR-451b) replicated.
other	35447890	hsa-mir-451b	Asthma	5p and miR-451b) replicated.
other	35447890	hsa-mir-7	Pulmonary Disease, Chronic Obstructive	5p and miR-451b) replicated.
other	35447890	hsa-mir-296	Pulmonary Disease, Chronic Obstructive	5p and miR-451b) replicated.
other	35447890	hsa-mir-7	Asthma	5p and miR-451b) replicated.
other	35447890	hsa-mir-451b	Pulmonary Disease, Chronic Obstructive	5p and miR-451b) replicated.
other	35447890	hsa-mir-532	Asthma	5p and miR-451b) replicated.
lncRNA target	35447001	hsa-mir-127	Thyroid Neoplasms	Mechanistically, hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR
other	35446623	hsa-mir-29a	Virus Diseases	Here, we interrogated the role of microRNAs (miRs) in CD8 T cells responding to acutely resolved or chronic viral infection and identified miR-29a as a key regulator of TEX. Enforced expression of miR-29a improved CD8 T cell responses during chronic viral infection and antagonized exhaustion.
lncRNA target	35446199	hsa-mir-760	Carcinoma, Renal Cell	Additionally, we found that linc01133 promotes RCC cell proliferation, migration and invasion through sponging miR-760.
circulation_biomarker_diagnosis_ns	35446157	hsa-mir-200b	Arteriovenous Fistula	CONCLUSION: Our study indicates that serum exosome-derived miR-200b-3p regulate VEGF and Ang-II to increase intimal hyperplasia to induce AVF thrombosis.
other	35446157	hsa-mir-200	Arteriovenous Fistula	Besides miR-200b-3p, miR-200 family may also play a regulatory role in AVF thrombosis.
other	35446157	hsa-mir-429	Arteriovenous Fistula	RESULTS: There are 43 miRNA down-regulation and 15 miRNA up-regulation between MHD group and MHD+Thrombus group, the expression levels of miR-200b-3p and miR-429 in MHD with thrombus were significantly increased (p < 0.001, p < 0.05).
circulation_biomarker_diagnosis_ns	35445913	hsa-mir-203	Urinary Bladder Neoplasms	miR-203 expression was considerably higher in serum of UBC patients but non-significant as compared to BPH controls.
other	35445913	hsa-mir-34a	Urinary Bladder Neoplasms	This study aimed to identify a CD44-linked microRNAs (miRNAs) (miR-9, miR-34a, miR-203) for non-invasive diagnosis of bladder cancer from other urinary tract malignancies.
other	35445913	hsa-mir-9	Urinary Bladder Neoplasms	This study aimed to identify a CD44-linked microRNAs (miRNAs) (miR-9, miR-34a, miR-203) for non-invasive diagnosis of bladder cancer from other urinary tract malignancies.
genetics_overexpression_promote	35445786	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of miR
lncRNA target	35445231	hsa-mir-223	Osteosarcoma	A series of in vitro anti-tumor assays illustrate that the PGEA-2 vector can efficiently deliver miR-223 into osteosarcoma cells for impressive anti-tumor effects via inhibiting malignant behavior of osteosarcoma cells, including proliferation, migration, and invasion.
circulation_biomarker_diagnosis_ns	35445179	hsa-mir-490	Breast Neoplasms	3p in peripheral blood mononuclear cells (PBMCs) and plasma of patients with BC.
other	35445044	hsa-mir-145	Retinopathy of Prematurity	Intravitreal injection of miR5p mimics reduced the degree of retinopathy.
transcription factor target	35445025	hsa-mir-513c	Venous Thrombosis	Collectively, these results revealed that the pyroptosis of VECs induced by decreased miR-513c-5p was involved in DVT progression and indicated a potential therapeutic strategy of targeting the miR-513c-5p/caspase-1/GSDMD signal axis for DVT management.
lncRNA target	35444864	hsa-mir-34a	Herpesviridae Infections	CONCLUSION: Upregulated miR-34a-5p in KSHV-infected SH-SY5Y cells suppressed cell proliferation and migration through down-regulating c-fos.
lncRNA target	35444785	hsa-mir-520a	Carcinoma, Non-Small-Cell Lung	More importantly, the suppression of SBF2-AS1 silencing on the proliferation, migration, and invasion in NSCLC cells was counteracted by miR-520a-3p inhibition.
circulation_biomarker_prognosis_ns	35444778	hsa-mir-184	Carcinoma, Non-Small-Cell Lung	The expression level of miR-184 in serum exosomes of NSCLC patients is significantly increased, which has a certain value for the differential diagnosis of the nature of benign and malignant lung diseases and is closely related to the prognosis of patients.
other	35444696	hsa-mir-29	Stomach Neoplasms	RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001).
other	35444696	hsa-mir-29a	Stomach Neoplasms	RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001).
other	35444696	hsa-mir-101	Stomach Neoplasms	CONCLUSION: It seems that determining the expression level of miR-101, -103, and -29, as the novel diagnostic biomarkers, has diagnostic value to distinguish GC patients from healthy individuals.
other	35444696	hsa-mir-103	Stomach Neoplasms	RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001).
genetics_knock down_promote	35444695	hsa-mir-520a	Carcinoma, Hepatocellular	Overexpression of miR-520a-3p and E2F7 knockdown reversed the role of circLATS2 in promoting malignant behavior of HCC cells and affected phosphorylation of VEGFR2.
circulation_biomarker_diagnosis_ns	35444657	hsa-mir-146a	Lupus Erythematosus, Systemic	However, miR146a was significantly decreased in SLE patients compared to healthy controls and was negatively correlated with plasma estradiol levels and with SLE disease activity scores (SLEDAI). In addition, we found that levels of miR21, miR25, and miR186 positively correlated with SLEDAI and miR146a was negatively correlated in SLE patients.
exosome	35444548	hsa-mir-20a	Uterine Cervical Neoplasms	Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.
transcription factor target	35444435	hsa-mir-138	Diabetic Foot	CONCLUSION: Down-regulation of miR-138 could alleviate inflammatory response and promote wound healing in DFU rats by activating PI3K/AKT pathway and hTERT.
other	35444105	hsa-mir-15a	Stomach Neoplasms	In GC tissues, the expression of SNCG was negatively correlated with that of miR-15a-5p, but was positively correlated with that of SLC25A21-AS1.
lncRNA target	35443866	hsa-mir-4733	Gallbladder Neoplasms	5p was upregulated in GBC and promoted GBC cell proliferation via directly binding to 3' untranslated region (UTR) of KLF, which was downregulated and prohibited the proliferation and migration of GBC cells.
genetics_knock down_suppress	35443864	hsa-mir-124	Fibrosis, Renal	In conclusion, KCNQ1OT1 knockdown plays an anti-fibrotic effect through promotion of miR3p expression in renal fibrosis, which provides a promising therapeutic target for the treatment of renal fibrosis.
lncRNA target	35443748	hsa-mir-125a	Squamous Cell Carcinoma of Head and Neck	Collectively, our study addresses that MIR600HG downregulation elevates miR-125a-5p and reduces RNF44 expression, thereby improving DDP sensitivity and inhibiting glycolysis in DDP-resistant OSCC cells.
lncRNA target	35443748	hsa-mir-600	Squamous Cell Carcinoma of Head and Neck	Collectively, our study addresses that MIR600HG downregulation elevates miR-125a-5p and reduces RNF44 expression, thereby improving DDP sensitivity and inhibiting glycolysis in DDP-resistant OSCC cells.
genetics_overexpression_promote	35443745	hsa-mir-146a	Colorectal Neoplasms	5p in CXCR7-overexpressing CRC cells and their exosomes.
genetics_overexpression_promote	35443745	hsa-mir-155	Colorectal Neoplasms	5p in CXCR7-overexpressing CRC cells and their exosomes.
genetics_overexpression_promote	35443670	hsa-mir-1	Thyroid Neoplasms	RESULTS: MIR31HG was overexpressed in human thyroid cancer, and its overexpression predicted poor prognosis.
circulation_biomarker_diagnosis_ns	35443588	hsa-mir-335	Diabetic Retinopathy	CONCLUSIONS: We concluded that plasma miR
other	35443023	hsa-mir-365	Bronchiolitis Obliterans Syndrome	3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD.
other	35443023	hsa-mir-148	Bronchiolitis Obliterans Syndrome	3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD.
other	35443023	hsa-mir-378	Bronchiolitis Obliterans Syndrome	3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD.
other	35442818	hsa-mir-130a	Alzheimer Disease	CONCLUSION: HOTAIR participated in the regulation of exercises on AD by sponging miR-130a-3p.
other	35442769	hsa-mir-888	Carcinoma, Ductal, Breast	Conclusions: Our study indicated that elevated eXpression of miR-888 may be a negative prognostic factor in breast cancer.
genetics_overexpression_promote	35442509	hsa-mir-298	Osteosarcoma	Overexpression of JMJD6 reversed the effect of overexpressed miR-298 on alleviating the malignant progression of osteosarcoma.
other	35442501	hsa-mir-1275	Carcinoma, Non-Small-Cell Lung	MiR-1275 promotes non-small cell lung cancer cell proliferation and metastasis by regulating LZTS3 expression.
transcription factor target	35442485	hsa-mir-543	Acute Kidney Injury	The downregulation of miR-543 remarkably inhibited the inflammation and apoptosis, which was manifested by the reduction of inflammatory cytokines (TNF-, IL-6, IL-1), the reversal of apoptosis-related proteins expression (Bcl-1, Bax), the increase of cell viability and the decrease of the proportion of apoptotic cells.
transcription factor target	35442485	hsa-mir-543	Sepsis	The downregulation of miR-543 remarkably inhibited the inflammation and apoptosis, which was manifested by the reduction of inflammatory cytokines (TNF-, IL-6, IL-1), the reversal of apoptosis-related proteins expression (Bcl-1, Bax), the increase of cell viability and the decrease of the proportion of apoptotic cells.
transcription factor target	35442159	hsa-mir-183	Skin Pigmentation	Thus, miR5p is an important regulator of melanocytes homeostasis and may be a novel target for autoimmune depigmentation therapy.
circulation_biomarker_prognosis_up	35442113	hsa-mir-200b	Multiple Organ Failure	Moreover, serum HMGB1 level was increased in MODS patients, and was negatively correlated with miR-200b-3p level.
lncRNA target	35441953	hsa-mir-761	Colorectal Neoplasms	LOXL1-AS1 contributed to CRC progression via modulating miR
lncRNA target	35441953	hsa-mir-1224	Colorectal Neoplasms	LOXL1-AS1 contributed to CRC progression via modulating miR
lncRNA target	35441676	hsa-mir-21	Lung Neoplasms	CONCLUSION: MiRNA-21 has potential clinical value in the diagnosis and prognosis of lung cancer and may serve as an effective diagnostic marker and therapeutic target in the future.
lncRNA target	35441583	hsa-mir-124	Polycystic Ovary Syndrome	These findings suggested that LINC00173 could be a latent regulating factor for PCOS progression via modulating the miR
lncRNA target	35441579	hsa-mir-1299	Carcinoma, Non-Small-Cell Lung	Through the luciferase activity assay to explore the relationship between MELTF-AS1 and miR-1299, to further understand the effect of silencing MELTF-AS1 on NSCLC. In addition, through luciferase activity analysis and bioinformatics analysis, MELTF-AS1 has a negative effect on miR-1299, and silencing MELTF-AS1 enhanced miR-1299 expression in NSCLC cells.
other	35441575	hsa-mir-192	Diabetic Retinopathy	Although microRNA-192 (miR-192) has been demonstrated to be involved in diabetic retinopathy progression, to the best of our knowledge, its potential and mechanism in cell pyroptosis in diabetic retinopathy have not been studied.
genetics_overexpression_promote	35441565	hsa-mir-218	Adenocarcinoma of Lung	ERO1A overexpression reversed the suppressive impacts of miR
circRNA target	35441564	hsa-mir-145	Small Cell Lung Carcinoma	Our data indicated that circMYC upregulates the expression of MMP-2 by inhibiting miR-145, which functions to promote the proliferation, migration, and invasion and inhibit the apoptosis of SCLC. These findings suggest that targeting circMYC/miR-145/MMP-2 could serve as a potential therapeutic strategy for SCLC treatment.
exosome	35441482	hsa-mir-138	Urinary Bladder Neoplasms	5p is a promising therapeutic agent for BC treatment.
genetics_overexpression_promote	35441352	hsa-mir-125b	Osteoarthritis	Inhibiting miR-23a/b-3p or overexpressing Grem1 activated transforming growth factor-beta/solvated metal atom dispersed 3 (TGF-beta/Smad) signaling to prevent OA development.
genetics_overexpression_promote	35441352	hsa-mir-23a	Osteoarthritis	Inhibiting miR-23a/b-3p or overexpressing Grem1 activated transforming growth factor-beta/solvated metal atom dispersed 3 (TGF-beta/Smad) signaling to prevent OA development.
transcription factor target	35440867	hsa-mir-146a	Endothelial Dysfunction	DISCUSSION: Effects of RUS on sepsis-induced impairments in endothelium relied on the suppression of miR-146a-5p.
circRNA target	35440759	hsa-mir-20a	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
circRNA target	35440759	hsa-mir-136	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
circRNA target	35440286	hsa-mir-134	Esophageal Squamous Cell Carcinoma	Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies.
lncRNA target	35440106	hsa-mir-532	Stomach Neoplasms	MiR-532 was decreased and negatively correlated with E2F1 in GC tissues. This study demonstrates the significant roles of the E2F1-miR-532 double-negative feedback loop in GC progression and may represent a potential target for GC therapy.
genetics_overexpression_promote	35439853	hsa-mir-503	Precursor Cell Lymphoblastic Leukemia-Lymphoma	induced increased sensitivity of ALL-resistant cells and CCRF/ CEM-R to dexamethasone was attenuated by overexpression of WNT3A.
other	35439827	hsa-mir-21	Spinal Cord Injuries	We aimed to elucidate the regulatory role of miR-21 and test methylprednisolone as a disease-modifying agent on experimental SCI tissues. CONCLUSIONS: miR-21 supports the beneficial aspects of the body's healing mechanisms following SCI.
lncRNA target	35439733	hsa-mir-27b	Osteoarthritis	These findings confirmed that the Circ_0000423-miRNA-27b-3p-MMP-13 axis could affect the pathogenesis of OA which might lead to a novel target for diagnostic molecular biological indicators and potential OA treatments.
other	35439640	hsa-mir-520a	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: The study revealed the roles of TTTY15/miR-520a-3p/IRF9 signaling pathway in regulating cerebral ischemia/reperfusion injury.
other	35439323	hsa-mir-93	Diabetes Mellitus, Type 2	5p and maybe involved in the pathogenesis of T2D.
other	35438846	hsa-mir-139	Carcinoma, Hepatocellular	5p negatively regulates the expression of NME1 in HCC cell lines.
lncRNA target	35438468	hsa-mir-155	Carcinoma, Hepatocellular	LPS-MIR155HG-PD-L1 regulatory axis provides a new target for the treatment of HCC.
lncRNA target	35438362	hsa-mir-187	Colorectal Neoplasms	CircCDC6, acting as a tumor inhibitor, repressed tumor growth and glycolysis metabolism in CRC via targeting the miR
transcription factor target	35437466	hsa-mir-27	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-34	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-9	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-29	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-21	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-26	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-146	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-181	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-140	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
transcription factor target	35437466	hsa-mir-155	Osteoarthritis	Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis.
other	35437351	hsa-mir-149	Aortic Dissection	qRT-PCR demonstrated that hsa_circRNA_082317 and ITGA5 were significantly up-regulated, and hsa-miR3p was dramatically down-regulated in AD (n = 3).
circRNA target	35436983	hsa-mir-661	Esophageal Squamous Cell Carcinoma	Our findings suggest that circFAM120B is a promising biomarker of ESCC, which acts as a tumor suppressor via the circFAM120B/miR-661/PPM1L axis and PKR/p38 MAPK/EMT pathway, supporting its significance as a candidate therapeutic target.
circulation_biomarker_diagnosis_ns	35436801	hsa-mir-126a	Brain Ischemia	Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and OBJECTIVE: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not.
circulation_biomarker_diagnosis_ns	35436801	hsa-mir-126a	Persistent Fetal Circulation Syndrome	Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and OBJECTIVE: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not.
other	35436780	hsa-mir-486	Lung Neoplasms	This biosensor can absolutely quantify the miR5p expression in different lung cancer cells and distinguish non-small cell lung cancer (NSCLC) patients from healthy individuals, holding great potential in biomedical research and clinical diagnosis.
other	35436733	hsa-mir-106b	Squamous Cell Carcinoma of Head and Neck	Herein, we proposed a pump-free surface-enhanced Raman scatting (SERS) microfluidic chip for the rapid and ultrasensitive detection of miR-106b and miR-196b, laryngeal squamous cell carcinoma (LSCC)-related miRNAs.
other	35436733	hsa-mir-196b	Squamous Cell Carcinoma of Head and Neck	Herein, we proposed a pump-free surface-enhanced Raman scatting (SERS) microfluidic chip for the rapid and ultrasensitive detection of miR-106b and miR-196b, laryngeal squamous cell carcinoma (LSCC)-related miRNAs.
other	35436654	hsa-mir-455	Pulmonary Arterial Hypertension	CONCLUSIONS: Elevated SOX2-OT is a feasible diagnostic marker for PAH, and its silencing may attenuated hypoxia-induced hPASMCs proliferation, migration, anti-apoptosis, and inflammation by modulating the miR3p/SUMO1 axis, preventing vascular remodeling and PAH progression.
circRNA target	35436629	hsa-mir-222	Diabetic Nephropathies	So, the axis of circ608-miR222-PINK1 was proved to participate in NASH-related liver fibrosis by regulating mitophagy. CONCLUSION: Circ608 could promote PINK1-mediated mitophagy of HSCs though inhibiting miR222 in NASH-related liver fibrosis.
circRNA target	35436629	hsa-mir-222	Carcinoma, Hepatocellular	So, the axis of circ608-miR222-PINK1 was proved to participate in NASH-related liver fibrosis by regulating mitophagy. CONCLUSION: Circ608 could promote PINK1-mediated mitophagy of HSCs though inhibiting miR222 in NASH-related liver fibrosis.
other	35436578	hsa-mir-193a	Neurofibromatosis 2	Moreover, hsa-miR-193a and hsa-miR-504 were identified as specifically upregulated miRNAs in sporadic NF2 and familial NF2, respectively.
other	35436578	hsa-mir-504	Neurofibromatosis 2	Moreover, hsa-miR-193a and hsa-miR-504 were identified as specifically upregulated miRNAs in sporadic NF2 and familial NF2, respectively.
circRNA target	35436516	hsa-mir-490	Glioma	3p/XRCC5/CLC3 ceRNA network, providing a novel prognostic biomarker and a prospective target for glioma treatment.
transcription factor target	35436510	hsa-mir-150	Hypoxia-Ischemia, Brain	Our results suggest that NSCs-Ex prevent cerebral injury by transferring miR3p which promotes neurons proliferation by inhibiting CASP2 signaling pathway.
lncRNA target	35436415	hsa-mir-199a	Carcinoma, Hepatocellular	The dual-luciferase assay showed that miR-199a-3p is not only a target for NRAV but also interacts with the 3' UTR of CISD2 in HCC cells. NRAV may trigger the Wnt/beta-catenin signaling via the modulation of the miR-199a-3p/CISD2 axis in HCC.
circulation_biomarker_diagnosis_ns	35436050	hsa-mir-92a-1	Multiple Sclerosis	hsa-miR-454 and hsa-miR-92a-1* relative expression was measured in the plasma of 31 MS patients, relapsing remitting MS (RRMS, n=21) and progressive MS (PMS, n=10) and 20 age and sex matched normal controls by using reverse transcription followed by real time PCR.
circulation_biomarker_prognosis_ns	35436050	hsa-mir-454	Multiple Sclerosis	hsa-miR-454 and hsa-miR-92a-1* relative expression was measured in the plasma of 31 MS patients, relapsing remitting MS (RRMS, n=21) and progressive MS (PMS, n=10) and 20 age and sex matched normal controls by using reverse transcription followed by real time PCR.
circulation_biomarker_diagnosis_ns	35435753	hsa-mir-451a	Tuberculosis	The baseline circulating levels of hsa-miR
circulation_biomarker_diagnosis_ns	35435604	hsa-mir-4442	Coronary Artery Disease	5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls.
circulation_biomarker_diagnosis_ns	35435604	hsa-mir-197	Coronary Artery Disease	5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls.
circulation_biomarker_diagnosis_ns	35435604	hsa-mir-24	Coronary Artery Disease	5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls.
circulation_biomarker_diagnosis_ns	35435604	hsa-mir-6069	Coronary Artery Disease	5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls.
circulation_biomarker_diagnosis_ns	35435604	hsa-mir-6879	Coronary Artery Disease	5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls.
lncRNA target	35435532	hsa-mir-130b	Intervertebral Disc Degeneration	These data demonstrated that the miR-130b-3p inhibition could upregulate the autophagic flux and alleviate the IVDD via targeting ATG14 and PRKAA1.The translational potential of this article: The suppression of miR-130b-3p may become an effective therapeutic strategy for IVDD.
lncRNA target	35435136	hsa-mir-183	Adenocarcinoma of Lung	5p, and regulates LATS1 to activate Hippo/YAP pathway, thereby inhibiting the process of LUAD cells.
other	35435133	hsa-mir-138	Vascular Calcification	In conclusion, this study demonstrates that the H19/miR-138/TLR3 axis is involved in high phosphorus-mediated vascular calcification in rats with CKD.
other	35435133	hsa-mir-138	Renal Insufficiency, Chronic	In conclusion, this study demonstrates that the H19/miR-138/TLR3 axis is involved in high phosphorus-mediated vascular calcification in rats with CKD.
other	35435130	hsa-mir-181a	Squamous Cell Carcinoma of Head and Neck	Quantitative real-time PCR and Western blotting were conducted for detecting the expressions of LINC00847, microRNA-181a-5p (miR-181a-5p) and zinc finger E-box binding homeobox 2 (ZEB2) in LSCC cell lines and tissue samples. Our data suggest that LINC00847 promotes LSCC progression by regulating the miR-181a-5p/ZEB2 axis.
lncRNA target	35435120	hsa-mir-421	Cholangiocarcinoma	These findings demonstrate that circSETD3 inhibits proliferation and induces apoptosis in CCA cells by regulating the miR-421/BMF axis, indicating its potential as a promising candidate for CCA therapy.
genetics_knock down_promote	35435118	hsa-mir-5590	Esophageal Neoplasms	3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR
genetics_knock down_promote	35435118	hsa-mir-5590	Urinary Bladder Neoplasms	3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR
circRNA target	35435117	hsa-mir-489	Stomach Neoplasms	AS-IV inhibited the development of GC through circDLST/miR
genetics_knock down_suppress	35435110	hsa-mir-613	Uterine Cervical Neoplasms	Knockdown of circ_0001823 inhibited the malignant behaviors of the CC cells via regulating the miR-613/RAB8A axis.
genetics_knock down_promote	35435107	hsa-mir-6888	Osteosarcoma	Changes in the proliferation and migration of OS cells were detected by Cell Counting Kit-8 (CCK-8) and transwell assays after the knockdown of HOTAIR, miR
genetics_overexpression_suppress	35435104	hsa-mir-27a	Cylindromatosis	LncRNA GAS5 overexpression inhibited proliferation of PitNETs cell line MMQ and GH3 cells and induced cell apoptosis, simultaneously, inhibited miR-27a-5p expression and increased CYLD expression.
genetics_overexpression_promote	35434854	hsa-mir-4701	Colorectal Neoplasms	5p to overexpress TUSC1, indicating that the circ_PLXNB1/miR
genetics_GWAS	35434480	hsa-mir-23b	Abortion, Habitual	OBJECTIVE: We surveyed the association between polymorphisms in pre-miR-125a, pre-miR-10a, pre-miR-323b, GPX4, and GPX4 in Iranian women with idiopathic RPL.
genetics_GWAS	35434480	hsa-mir-10a	Abortion, Habitual	RESULTS: The frequencies of polymorphisms in pre-miR-125a (p < 0.001) and pre-miR-10a (p = 0.04) were calculated among the case and control groups, which showed a statistical difference (p < 0.05), indicating an association between these polymorphisms and the symptoms of RPL.
genetics_GWAS	35434480	hsa-mir-125a	Abortion, Habitual	RESULTS: The frequencies of polymorphisms in pre-miR-125a (p < 0.001) and pre-miR-10a (p = 0.04) were calculated among the case and control groups, which showed a statistical difference (p < 0.05), indicating an association between these polymorphisms and the symptoms of RPL.
lncRNA target	35434335	hsa-mir-144	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: CircLPAR3 exerted a tumor-promoting effect on OSCC growth through elevating LPCAT1 expression via functioning as a miR
other	35434044	hsa-mir-371a	Atherosclerosis	This article will explore the role of the lncRNA COLCA1 (colorectal cancer associated 1)/hsa-miR-371a-5p/SPP1 (secreted phosphoprotein 1) pathway in oxLDL in causing human coronary artery endothelial cells (HCAECs) inflammation and related biological function changes.
other	35434020	hsa-mir-146a	Conjunctivitis, Allergic	CONCLUSIONS: We demonstrated a possible protective mechanism by the miR-146a/HIPK3/STAT3 axis, by which decrease of miR-146a could aggravate the inflammation of AC.
lncRNA target	35433983	hsa-mir-19a	Carcinoma, Pancreatic Ductal	Subsequently, we found that miR-19a-3p binds to TBK1 in PDAC and LINC00483 could regulate PDAC cell progression by regulating miR-19a-3p via the TBK1/MAPK pathway. CONCLUSIONS: The results of our study suggested that the LINC00483/miR-19a-3p/TBK1/MAPK axis contributed to PDAC progression, which provides a potential therapeutic target for PDAC treatment.
lncRNA target	35433983	hsa-mir-19a	Pancreatic Carcinoma	Subsequently, we found that miR-19a-3p binds to TBK1 in PDAC and LINC00483 could regulate PDAC cell progression by regulating miR-19a-3p via the TBK1/MAPK pathway. CONCLUSIONS: The results of our study suggested that the LINC00483/miR-19a-3p/TBK1/MAPK axis contributed to PDAC progression, which provides a potential therapeutic target for PDAC treatment.
other	35433971	hsa-mir-198	Aortic Aneurysm	RT-qPCR and TSA-ISH assays showed the upregulation of miR-4306 and the downregulation of miR-3198 in AA tissue samples.
other	35433971	hsa-mir-4306	Aortic Aneurysm	RT-qPCR and TSA-ISH assays showed the upregulation of miR-4306 and the downregulation of miR-3198 in AA tissue samples.
genetics_overexpression_promote	35433959	hsa-mir-28	Carcinoma, Non-Small-Cell Lung	Overexpressed miR
transcription factor target	35433958	hsa-mir-129	Dmd-Associated Dilated Cardiomyopathy	CONCLUSIONS: In conclusion, we speculate that miR5p might target ASPN in regulating DCM via the ECM signaling pathway.
other	35433957	hsa-mir-3163	Pancreatic Carcinoma	Mechanistically, DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells.
lncRNA target	35433915	hsa-mir-29c	Epstein-Barr Virus Infections	The functional enrichment of the above DEGs indicates that miR-29c is a potential regulator of oxidative stress and inflammatory response in bMECs through multiple genes, such as forkhead box O1 (FOXO1), tumor necrosis factor-alpha (TNF-alpha), and major histocompatibility complex, class II, DQ alpha 5 (BoLA-DQA5) in the various biological process and signaling pathways of stress-activated mitogen-activated protein kinase (MAPK) cascade, Epstein-Barr virus infection, inflammatory bowel disease, etc.
lncRNA target	35433915	hsa-mir-29c	Inflammatory Bowel Diseases	The functional enrichment of the above DEGs indicates that miR-29c is a potential regulator of oxidative stress and inflammatory response in bMECs through multiple genes, such as forkhead box O1 (FOXO1), tumor necrosis factor-alpha (TNF-alpha), and major histocompatibility complex, class II, DQ alpha 5 (BoLA-DQA5) in the various biological process and signaling pathways of stress-activated mitogen-activated protein kinase (MAPK) cascade, Epstein-Barr virus infection, inflammatory bowel disease, etc.
transcription factor target	35433915	hsa-mir-29c	Mastitis	The results imply that miR-29c plays an important role in a steady state of bMECs or cow mammary gland and may be a potential therapeutic target for mastitis in dairy cows.
epigenetics	35433692	hsa-mir-211	Anxiety Disorders	5p via Trpm1 demethylation, and miR
lncRNA target	35433661	hsa-mir-195	Esophageal Squamous Cell Carcinoma	Conclusion: In summary, elevated LINC00662 transferred by ESCC cells-derived EVs induces angiogenesis through downregulating miR
target gene	35433535	hsa-mir-34a	Bronchopulmonary Dysplasia	Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway.
other	35433464	hsa-mir-139	Breast Neoplasms	miR-139-5p Was Identified as Biomarker of Different Molecular Subtypes of Breast Carcinoma.
circulation_biomarker_prognosis_ns	35433428	hsa-mir-199a	Uveal melanoma	5p (p < 0.001) were found in serum of metastatic UM patients compared to patients with localized spindle-shaped melanoma, and significantly higher levels of miR-199a-3p (p < 0.001) were detected in serum of metastatic UM patients compared to healthy controls.
circulation_biomarker_diagnosis_up	35433428	hsa-mir-214	Uveal melanoma	3p and, conversely, were significantly downregulated in serum of epithelioid cell melanoma patients.
circulation_biomarker_prognosis_ns	35433428	hsa-mir-21	Uveal melanoma	Our preliminary data indicate promising diagnostic utility of circulating miR-199a-3p and promising prognostic utility of circulating miR
genetics_overexpression_suppress	35433237	hsa-mir-1266	Colonic Neoplasms	3p inhibited the growth and metastasis of colon cancer in vitro as well as in vivo, and this effect could be alleviated by overexpressing P4HA3.
circulation_biomarker_diagnosis_ns	35432916	hsa-mir-214	Parkinson Disease	5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD.
circulation_biomarker_diagnosis_ns	35432916	hsa-mir-31	Parkinson Disease	5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD.
circulation_biomarker_diagnosis_ns	35432916	hsa-mir-485	Parkinson Disease	5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD.
circulation_biomarker_diagnosis_ns	35432916	hsa-mir-24	Parkinson Disease	5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD.
circulation_biomarker_diagnosis_ns	35432916	hsa-mir-151a	Parkinson Disease	5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD.
other	35432732	hsa-mir-224	Cardiomyopathies	We showed miRNA224-5p, the most upregulated miRNA in HP-EVs, directly combined the 3' untranslated region of TXNIP and demonstrated its critical protective role against hypoxia-mediated CM injury.
transcription factor target	35432725	hsa-mir-199a	Diabetic Foot	miR-199a-5p and its targets showed therapeutic effect on diabetic wounds.
exosome	35432524	hsa-mir-133a	Carcinoma, Hepatocellular	We examined the metastatic ability of HCC cells after IL-6 treatment and found that miR-133a-3p was sorted into exosomes after IL-6 stimulation and was subsequently released into the tumor microenvironment. In vitro analysis confirmed that exosomal miR-133a-3p acted as a tumor suppressor in HCC.
lncRNA target	35432472	hsa-mir-372	Colonic Neoplasms	3p Functions as a Tumor Suppressor in Colon Cancer by Targeting MAP3K2.
other	35432462	hsa-mir-126	Hypertension	We identified the combination of miR3p and 126-5p as potential endogenous control in studies of hypertension.
other	35432462	hsa-mir-223	Hypertension	We identified the combination of miR3p and 126-5p as potential endogenous control in studies of hypertension.
other	35432445	hsa-mir-617	Prostatic Neoplasms	Using normal tissue models, we identified two significant TWAS microRNA associations with PrCa risk: over-expression of mir-941 family microRNAs (P(TWAS) = 2.9E-04) and reduced expression of miR5p (P(TWAS) = 1.0E-03).
other	35432445	hsa-mir-941	Prostatic Neoplasms	Using normal tissue models, we identified two significant TWAS microRNA associations with PrCa risk: over-expression of mir-941 family microRNAs (P(TWAS) = 2.9E-04) and reduced expression of miR5p (P(TWAS) = 1.0E-03).
other	35432384	hsa-mir-181d	Sjogren's Syndrome	Further dissection of the pathophysiological mechanisms underlying the hsa-miR-181d-5p-mediated action in inflammatory conditions could be useful to evaluate the benefits of increasing hsa-miR-181d-5p levels for restoration of salivary gland epithelial cell architecture and function.
circulation_biomarker_diagnosis_ns	35432357	hsa-mir-144	Asthma	3p is associated with severe diseases in both the airways and serum of asthmatics, and this association is related to corticosteroid treatment.
other	35432149	hsa-mir-204	Myasthenia Gravis with Thymus Hyperplasia	CONCLUSIONS: In this research, we constructed a ceRNA network involved in the progression of TAMG, discovered that thymic Tregs were significantly decreased in patients with TAMG, and assumed that the LINC00452/miR-204/CHST4 axis may regulate thymic Tregs in the development of TAMG.
genetics_overexpression_promote	35431959	hsa-mir-133c	Arthritis	Overexpression of NR-133666 and MAPK1 can promote the proliferation and migration of CIA FLS, and overexpression of miR-133c can reverse this phenomenon. Collectively, we identified that lncRNA NR-133666 acted as a miR-133c sponge that can promote the proliferation and migration of CIA FLS through regulating the miR-133c/MAPK1 axis.
other	35431948	hsa-mir-199	Lung Injury	Conclusion: Paraquat induces ALI by affecting miRmediated SET.
other	35431233	hsa-mir-497	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: ELFN1-AS1 acts as an independent prognostic biomarker and tumor promoter of NSCLC by sponging miR-497/CCNE1 axis.
circulation_biomarker_diagnosis_ns	35431230	hsa-mir-195	Adenocarcinoma of Lung	MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors.
circulation_biomarker_diagnosis_ns	35431230	hsa-mir-15b	Adenocarcinoma of Lung	MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors.
circulation_biomarker_diagnosis_ns	35431230	hsa-mir-193b	Adenocarcinoma of Lung	MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors.
circulation_biomarker_diagnosis_ns	35431230	hsa-mir-148a	Adenocarcinoma of Lung	MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors.
lncRNA target	35430766	hsa-mir-125b	Drug Hypersensitivity	We evaluate the anti-cancer activity of two novel RIG-I agonists, the immunomodulatory RNA (immRNA) with a unique secondary structure for efficient RIG-I activation, and a 5' triphosphorylated antisense oligonucleotide with dual function of RIG-I activation and miR-125b inhibition (3p-125b-ASO).
genetics_knock down_promote	35430713	hsa-mir-381	Uterine Cervical Neoplasms	FLVCR1-AS1 or MAGT1 knockdown or miR
lncRNA target	35430618	hsa-mir-1227	Fetal Growth Retardation	3p may participate in the development of FGR via regulating trophoblast cell proliferation and apoptosis by targeting genes involved in the insulin pathway.
lncRNA target	35430304	hsa-mir-99a	Obesity	CONCLUSIONS: MIR99AHG enhances adipogenesis by regulating miR-29b-3p and PPARgamma, providing a new target for therapeutic intervention in obesity.
circulation_biomarker_diagnosis_up	35430138	hsa-mir-2909	Urinary Bladder Neoplasms	On multivariate analysis, serum free testosterone (hazards ratio [HR]: 8.9; 95% CI: 1.8-45.1; P=0.008), serum AR1 (HR: 0.5; 95% CI: 0.3-0.9; P=0.02), and plasma miRNA-2909 (HR: 5.8; 95% CI: 2.3-14.7; P=0.0002), and tissue AR2 (HR: 2.6; 95% CI: 1.4-4.7; P=0.002) were independent predictor for NMIBC recurrence.
lncRNA target	35429679	hsa-mir-1538	Colorectal Neoplasms	Functional and mechanism experiments showed that miR-1538 decreased the protein level of DNA methyltransferases 3A (DNMT3A) and inhibited the proliferation, migration and invasion of CRC cells by targeting the 3'-UTR of DNMT3A mRNA.
genetics_knock down_suppress	35429078	hsa-mir-411	Carcinoma, Hepatocellular	5p reversed STAT3 and PD-L1 expression inhibited by MIAT knockdown in HCC cells.
genetics_overexpression_promote	35428780	hsa-mir-15a	Cholangiocarcinoma	Overexpression of miR-15a-5p promoted apoptosis but suppressed malignancy and tumorigenicity of CCA cells as well as EMT through downregulating CHEK1.
circRNA target	35428519	hsa-mir-874	Nasopharyngeal Carcinoma	3p alleviated the suppressive effects of circ_0081534 silencing on NPC cell malignant phenotypes.
other	35428200	hsa-mir-374b	Arteriosclerosis Obliterans	5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO.
other	35428200	hsa-mir-21	Arteriosclerosis Obliterans	5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO.
other	35428200	hsa-mir-29b	Arteriosclerosis Obliterans	5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO.
other	35428200	hsa-mir-150	Arteriosclerosis Obliterans	5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO.
other	35428200	hsa-mir-142	Arteriosclerosis Obliterans	5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO.
genetics_overexpression_promote	35427992	hsa-mir-223	Sezary Syndrome	Consequently, overexpression of miR
other	35427886	hsa-mir-381	Attention Deficit Disorder with Hyperactivity	Although microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR3p on the osteogenic differentiation in MBDMSCs is still unclear.
other	35427886	hsa-mir-381	Multiple Mitochondrial Dysfunctions Syndrome	Although microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR3p on the osteogenic differentiation in MBDMSCs is still unclear.
genetics_overexpression_promote	35427425	hsa-mir-1306	Melanoma	Functional assays further sustained that overexpressed miR
genetics_overexpression_promote	35427373	hsa-mir-542	Colorectal Neoplasms	Thus, we further verified that overexpression of integrin-linked kinase on down-regulated long non-coding RNA cancer susceptibility candidate 9 or up-regulated miR
genetics_knock down_suppress	35426617	hsa-mir-410	Colorectal Neoplasms	Furthermore, circTMEM59 inhibited CRC tumor growth by overexpressing HOXD8 through sponging miR
other	35426476	hsa-mir-124	Alzheimer Disease	3p/BACE1 pathway modulation is critically involved in Pb-induced AD-like amyloidogenic processing.
transcription factor target	35426328	hsa-mir-224	Carcinoma, Hepatocellular	CONCLUSION: PS-T increases the sensitivity of human hepatoma cells to OXA via the miR5p/ABCB1/P-gp axis.
other	35426258	hsa-mir-34c	Parkinson Disease	CONCLUSION: Our study first proved LINC00667, miR-34c-5p, and HNF4A constructed a positive feedback loop in MPP(+) -treated SH-SY5Y cells, enriching our understanding of PD.
lncRNA target	35426242	hsa-mir-429	Adenocarcinoma of Lung	LINC00365, miR-429, and KCTD12 expression in the LAD clinical tissues and cells were detcetd by qRT-PCR and Western blot. Thus, LINC00365 inhibited LAD progression and glycolysis via targeting miR-429/KCTD12 axis.
circulation_biomarker_diagnosis_ns	35426182	hsa-mir-125b	Sepsis	RESULTS: In the serum of sepsis patients and lipopolysaccharide(LPS)-induced U937 cells, MALAT1, STAT3, and PCT gene expression levels were significantly increased, while miR-125b expression level was decreased.
other	35425712	hsa-mir-10a	Kidney Neoplasms	BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells.
other	35424703	hsa-mir-155	Breast Neoplasms	Their over-expression correlates with various pathologies: for instance, miRNA-155 (miR-155) is over-expressed upon the development of breast cancers.
lncRNA target	35422914	hsa-mir-199a	Triple Negative Breast Neoplasms	Ectopic miR-199a-3p in TNBC cells exerted inhibitory effects on cell proliferation, migration and xenograft tumor growth.
genetics_knock down_suppress	35422898	hsa-mir-124	Retinoblastoma	miR-124 inhibition or c-myc overexpression partially reversed the effects of UCA1 knockdown on retinoblastoma cells. Overall, lncRNA UCA1 may exert an oncogenic effect on retinoblastoma progression through the miR-124/c-myc axis, which might serve as a promising retinoblastoma treatment target.
genetics_overexpression_suppress	35422889	hsa-mir-532	Osteosarcoma	3p overexpression inhibits luciferase activity of DARS-AS1-WT, not DARS-AS1-MUT in MG-63 cell.
other	35422846	hsa-mir-142	Myocardial Infarction, Acute	3p/BCL6 axis.
other	35422846	hsa-mir-139	Myocardial Infarction, Acute	3p/BCL6 axis.
other	35422846	hsa-mir-545	Myocardial Infarction, Acute	3p/BCL6 axis.
other	35422840	hsa-mir-27a	familial temporal lobe epilepsy 3	miR-27a-3p was capable of regulating multiple mTLE ion channel-related DEGs. Moreover, the network of miR-27a-3p regulating ion channel genes will be of great value in mTLE.
other	35422807	hsa-mir-21	Neuroaxonal Dystrophies	Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422807	hsa-mir-21	Autoimmune Diseases	Based on the microarray findings, we subsequently focused on two miRNAs (miRNA-21 and miRNA-690), which are known to be involved in inflammation and autoimmune response. Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422807	hsa-mir-690	Inflammation	Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422807	hsa-mir-21	Inflammation	Based on the microarray findings, we subsequently focused on two miRNAs (miRNA-21 and miRNA-690), which are known to be involved in inflammation and autoimmune response. Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422807	hsa-mir-690	Neuroaxonal Dystrophies	Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422807	hsa-mir-690	Autoimmune Diseases	Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs.
other	35422654	hsa-mir-486	Arthritis, Rheumatoid	5p-XIST) related to the pathogenesis of RA.
other	35422654	hsa-mir-1226	Arthritis, Rheumatoid	5p-XIST) related to the pathogenesis of RA.
other	35422654	hsa-mir-5581	Arthritis, Rheumatoid	5p-XIST) related to the pathogenesis of RA.
other	35422654	hsa-mir-338	Arthritis, Rheumatoid	5p-XIST) related to the pathogenesis of RA.
exosome	35422485	hsa-mir-182	Myocardial Reperfusion Injury	Furthermore, MSC-derived exosomes carrying miR5p improved cardiac function and reduced myocardial infarction, accompanied with reduced inflammation and cell pyroptosis in vivo.
genetics_GWAS	35422450	hsa-mir-181b	Crohn Disease	CONCLUSIONS: In conclusion, our study demonstrated that two SNPs, rs322931 (C>T) in miR-181b and rs7158663 (G>A) in MEG3, could aggravate the inflammatory response of anal abscess in patients with Crohn's disease via modulating the MEG3/miR-181b/TNF-alpha signaling pathway.
transcription factor target	35422233	hsa-mir-7	Diabetes, Gestational	CONCLUSION: Thus, an elevated level of miRNA7 may be associated with the progression of GDM by altering the multiple pathways like insulin, GnRH, and inflammatory signaling pathways via targeting IRS1, IRS2, and RAF1, implicating a new therapeutic target for GDM.
genetics_overexpression_promote	35422021	hsa-mir-377	Osteoarthritis	RESULTS: PRNCR1 was overexpressed in OA, while miR
exosome	35421904	hsa-mir-17	Ischemic Stroke	Alterations of miRNA-17 family and miRNA92 cluster were identified in preclinical, clinical and MSC-EV-mediated neuroprotection in experimental stroke.
genetics_overexpression_suppress	35421879	hsa-let-7a	Breast Neoplasms	In response to the overexpressed miR-155 in breast cancer cells, the hybrids disintegrate and release let-7a and the complementary DNA of miR-155 to inhibit the expression of HMGA1 and relieve the inhibition of SOX1, respectively.
genetics_overexpression_suppress	35421879	hsa-mir-155	Breast Neoplasms	In response to the overexpressed miR-155 in breast cancer cells, the hybrids disintegrate and release let-7a and the complementary DNA of miR-155 to inhibit the expression of HMGA1 and relieve the inhibition of SOX1, respectively.
circulation_biomarker_prognosis_up	35421866	hsa-mir-138	Cerebral Infarction, Acute	The ROC curve demonstrated the diagnostic potential of serum miR
transcription factor target	35421737	hsa-mir-449c	Sepsis	RT-PCR, Western blotting, ELISA, CCK8, EDU and luciferase reporter genes were used to verify whether miR-449c-5p could alleviate the apoptosis of vascular endothelial cells and the release of inflammatory factors during the progression of sepsis by inhibiting the expression of TAK1.
circulation_biomarker_diagnosis_ns	35421672	hsa-mir-21	hereditary diffuse gastric cancer	The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40).
circulation_biomarker_diagnosis_ns	35421672	hsa-mir-21	Corneal dystrophy, epithelial basement membrane	The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40).
circulation_biomarker_diagnosis_ns	35421672	hsa-mir-21	Precancerous Conditions	The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40).
genetics_knock down_promote	35421264	hsa-mir-26a	Nasopharyngeal Carcinoma	CONCLUSION: LINC00240 knockdown restrained cell proliferation, invasion, migration, and angiogenesis, while it advanced apoptosis via miR-26a-5p in NPC by EZH2 inhibition.
other	35421166	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	For miR-21 detection, matched tissue samples from 30 head and neck squamous cell carcinoma (HNSCC) patients and 8 head and neck cancer (HNC) cell lines were obtained. Compared to the corresponding normal control (NC) tissues, 25 cancer tissues had miR-21 upregulation among the 30 matched pair tissues (25/30, 83.8%); furthermore, among the 8 HNC cell lines, miR-21 expression that was notably upregulated in three: UPCI-4B, UMSCC-1, and UPCI-15B.
circulation_biomarker_diagnosis_up	35421066	hsa-mir-148a	Pre-Eclampsia	To study the relationship between miR-148a and preeclampsia (PE), and clarify that miR-148a can regulate the endoplasmic reticulum stress (ERS) of placental trophoblasts by targeting the ERS protein X box binding protein 1 (XBP1).Fifty patients with hypertension during pregnancy, patients with mild PE, patients with severe PE, and normal pregnant women were selected, and their placental tissues were collected. GRP78, CHOP, and caspase-12 expression result in anti-miR-148a group was decreased.miR-148a can regulate the ERS-mediated apoptosis by targeting XBP1, thereby intervening in the occurrence and development of PE.
genetics_knock down_promote	35420507	hsa-mir-4284	Uterine Cervical Neoplasms	However, the inhibitory effect of PGM5-AS1 overexpression on CC cells was partly relieved by DCN knockdown because of the targeting interaction between PGM5-AS1, miR-4284, and DCN.
lncRNA target	35420127	hsa-mir-124	Cleft Palate	5p inhibitors rescued atRA-induced CP with almost complete penetrance.
genetics_GWAS	35419790	hsa-mir-124	Leiomyoma	This study demonstrates that MED12 exon 2 mutations and probably microRNA-124 gene expressions might contribute to uterine leiomyoma pathology.
lncRNA target	35419295	hsa-mir-497	Nasopharyngeal Carcinoma	Mechanism research confirmed CASC9 regulated the malignant biological behavior of nasopharyngeal carcinoma cells by targeting miR5p/Wnt3a/beta-catenin signaling pathway.
genetics_overexpression_suppress	35419056	hsa-mir-129	Triple Negative Breast Neoplasms	5p or overexpression of POM121 reversed the inhibitory effect of sh-circints4 on the development of ADR-resistant TNBC cells.
other	35419033	hsa-mir-19b	Metabolic Diseases	Unexpectedly, in the same line of experiments, sperm RNA from animals raised on a normal diet when mixed with the sperm RNA from animals raised on a diet high in fat or synthetic miR-19b (inducer of obesity) affects or prevents the development of obesity and diabetes.
other	35418653	hsa-mir-6777	Glaucoma	5p was commonly downregulated in both PEX glaucoma and NTG patients.
other	35418237	hsa-mir-126	Vascular Diseases	For vascular tissues, miR-126 is one of the most important regulators and might have substantial application potential in maintaining vascular homeostasis.
lncRNA target	35418193	hsa-mir-130b	Pancreatic Carcinoma	In conclusion, the current study indicated that LINC00857 promotes PC tumorigenesis and metastasis by modulating the miR-130b/RHOA axis, implying that LINC00857 might be a new therapeutic target for PC.
genetics_overexpression_promote	35418191	hsa-mir-5581	Urinary Bladder Neoplasms	3p partially rescued the effects of the overexpressing SMAD3 and FTO in BCa cells.
other	35418181	hsa-mir-92a	Osteolysis	In summary, our study suggests the key role of miR-92a/KLF4/p110delta signal in TiPs-induced macrophages inflammation and osteolysis.
circRNA target	35418175	hsa-mir-510	Gastric Cancer, Early	In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients.
circRNA target	35418175	hsa-mir-942	Gastric Cancer, Early	In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients.
circulation_biomarker_diagnosis_up	35418162	hsa-mir-526b	Glioblastoma	In GBM cells, HOTAIR competitively bound to miR-526b-3p and weakened miR-526b-3p's binding ability to EVA1, thus increasing the expression of EVA1. GBM-serum-EV-enclosed HOTAIR may augment GBM progression and chemoresistance through miR-526b-3p downregulation and EVA1 upregulation.
genetics_overexpression_suppress	35417749	hsa-mir-1294	Carcinoma, Hepatocellular	Overexpression of IRGQ restored miR
genetics_GWAS	35417465	hsa-mir-21	Fatty Liver	In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c).
transcription factor target	35417465	hsa-mir-122	Fatty Liver	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).
transcription factor target	35417465	hsa-mir-34a	Fatty Liver	Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL).
lncRNA target	35416858	hsa-mir-126	Myocardial Reperfusion Injury	CONCLUSIONS: Naringin preconditioning can reduce myocardial I/R injury via regulating miR-126/GSK-3beta/beta-catenin signaling pathway, and this chemical can be used to treat acute myocardial infarction.
transcription factor target	35416554	hsa-mir-145	Cardiomyopathies	CONCLUSION: These results indicated that miR-145 upregulation could improve cardiac dysfunction and cardiac fibrosis by inhibiting MAP3K3 in heart failure. Thus, upregulating miR-145 or blocking MAP3K3 can be used to treat heart failure and cardiac fibrosis.
lncRNA target	35416273	hsa-mir-384	Neurotoxicity Syndromes	5p regulates ketamine-induced neurotoxicity in hippocampal neurons by targeting GABRB1.
lncRNA target	35416269	hsa-mir-29c	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1.
genetics_overexpression_suppress	35416128	hsa-mir-1306	Colorectal Neoplasms	Overexpression of miR
genetics_overexpression_promote	35416122	hsa-mir-18	Stomach Neoplasms	In this research, gastric cancer cell lines with stable overexpression of miR-18 were constructed through lentivirus infection.
other	35415740	hsa-mir-7111	Esophageal Squamous Cell Carcinoma	5p both showed lower expression levels in ESCC patients than those in healthy individuals.
other	35415740	hsa-mir-6763	Esophageal Squamous Cell Carcinoma	5p both showed lower expression levels in ESCC patients than those in healthy individuals.
transcription factor target	35415462	hsa-mir-92b	Acquired Immunodeficiency Syndrome	Our findings also suggest that out of a pool of dysregulated miRNAs studied by us, hsa-miR-92b-5p regulates coronin 1A expression under the effect of HIV-1 Tat.
transcription factor target	35415251	hsa-mir-22	Cryptorchidism	5p regulates SSCs' self-renewal by targeting EZH2, which indicated that miR
transcription factor target	35415251	hsa-mir-22	Infertility	5p regulates SSCs' self-renewal by targeting EZH2, which indicated that miR
other	35415250	hsa-mir-1283	Adenocarcinoma of Lung	In conclusion, circ_0020123 interacts with miR-1283 as a ceRNA to regulate PDZD8 expression, thus promoting the proliferation and migration of LUAD cells.
circRNA target	35415249	hsa-mir-942	Pre-Eclampsia	To sum up, our results revealed that circ_0085296 could inhibit trophoblast cells proliferation, migration, invasion, and angiogenesis by regulating miR5p/THBS2, confirming that circ_0085296 might be a potential therapeutic target for PE.
other	35415247	hsa-mir-340	Endometriosis	5p in endometriosis is unclarified.
genetics_knock down_suppress	35415236	hsa-mir-377	Carcinoma, Hepatocellular	Moreover, overexpression of miR
lncRNA target	35415017	hsa-mir-145	Stomach Neoplasms	We hypothesize that hsacirc_004413 makes gastric cancer cells resistant to 5-Fu mainly through adsorption of miR5p.
genetics_overexpression_promote	35414782	hsa-mir-148a	Carcinoma, Hepatocellular	We found that miR-148a-3p was downregulated in co-cultured HSCs and overexpression of miR-148a-3p in HSCs impaired the proliferation and invasiveness of HCC both in vitro and in vivo.
genetics_knock down_promote	35414500	hsa-mir-561	Carcinoma, Pancreatic Ductal	CONCLUSION: The overexpression of miR
genetics_knock down_suppress	35414334	hsa-mir-1252	Uterine Cervical Neoplasms	Rescue experiments found that miR5p overexpression or EIF4EBP2 knockdown could reverse the influence on CC cells caused by circ_0000190 overexpression.
lncRNA target	35414313	hsa-mir-139	Endometriosis	Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR
genetics_knock down_promote	35414011	hsa-mir-142	Cardiomyopathies	3p overexpression attenuated apoptosis and pyroptosis in cardiomyocytes, which was partly counteracted by ATXN1L overexpression.
transcription factor target	35413838	hsa-mir-489	Carcinoma, Non-Small-Cell Lung	3p promotes the malignant progression of NSCLC cells via targeting USP48, which might offer a new perspective into NSCLC treatment.
genetics_knock down_suppress	35413678	hsa-mir-24	Myocardial Reperfusion Injury	CONCLUSION: Circ_0050908 knockdown protects cardiomyocytes against I/R injury by reducing apoptosis, inflammatory response, and oxidative stress through miR
genetics_overexpression_suppress	35413598	hsa-mir-338	Stomach Neoplasms	CONCLUSION: The overexpression of circ_0051620 is found to be associated with progress and poor prognosis of GC, promoting the development and metastasis via sponging miR
virus_miRNA	35413475	kshv-mir-K12-1	Sarcoma, Kaposi	Kaposi's sarcoma-associated herpes virus-derived microRNA K12-1 over-activates the PI3K/Akt pathway to facilitate cancer progression in HIV-related gastrointestinal Kaposi's sarcoma
lncRNA target	35413439	hsa-mir-215	Inflammation	5p might be novel potential treatment targets in bacterial infection-related myocardial damages.
genetics_overexpression_promote	35413430	hsa-mir-193a	Ovarian Neoplasms	Rescue experiments exhibited two results: miR-193a-5p hindered proliferation, migration and invasion of ovarian cancer cells, and this suppression was counteracted by overexpression of RAB11A and miR-193a-5p.
genetics_overexpression_suppress	35413218	hsa-mir-622	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MiR-622 restoration inhibited AML cell proliferation and induced cell apoptosis, while RAB10 overexpression abolished these effects. CONCLUSION: : Circ_KCNQ5 high expression was associated with childhood AML malignant development, and circ_KCNQ5 participated in AML progression by regulating the miR-622/RAB10 pathway.
genetics_knock down_promote	35413135	hsa-mir-182	Prostatic Neoplasms	N6-methyladenosine (m6A) RNA immunoprecipitation assay (MeRIP) and co-immunoprecipitations assays were performed to verified that METTL3 upregulated the m6A level, interacted with microprocessor protein DGCR8, recognized the m6A modification of pre-miR-182 to regulate its maturation.METTL3 was highly expressed in prostate cancer, and knockdown of METTL3 significantly inhibited cell proliferation, migration, invasion and tumorigenesis, while overexpression of METTL3 promoted cell proliferation, migration, invasion and tumorigenesis in PCa.
lncRNA target	35412956	hsa-mir-642b	Stomach Neoplasms	Overall, miR-642b-3p acts as an oncomiR promoting tumor development in GC through suppressing CSMD1 expression and inactivating the Smad signaling pathway, which may enable the development of new therapeutic strategies for treatment of GC.
lncRNA target	35412955	hsa-mir-4731	Carcinoma, Renal Cell	In conclusion, circEHD2 enhances RCC resistance to SU via acting as a miR
lncRNA target	35412954	hsa-mir-876	Triple Negative Breast Neoplasms	Additionally, miR5p was demonstrated to be a target of LINC01315 and regulate the expression of GRK5, through which LINC01315 modulated the progression of TNBC.
lncRNA target	35412951	hsa-mir-378a	Ovarian Neoplasms	Furthermore, via inhibition of Wnt5a, miR-378a-3p alleviated DDP resistance in OC cells.
other	35412947	hsa-mir-129	Prostatic Neoplasms	5p.
genetics_overexpression_promote	35412941	hsa-mir-134	Leukemia, Myeloid, Acute	Functionally, circ_0004277 overexpression or inhibition of miR
other	35412895	hsa-mir-126	Leukemia	Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth.
other	35412895	hsa-mir-126	Leukemia, Myeloid, Acute	Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth.
other	35412895	hsa-mir-155	Leukemia	Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth.
other	35412895	hsa-mir-155	Leukemia, Myeloid, Acute	Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth.
lncRNA target	35412486	hsa-mir-552	Inflammatory Bowel Diseases	CONCLUSION: NORAD participates in TNF-alpha-induced FHC apoptosis, inflammation, and oxidative stress via the NF-kappaB signaling via the miR3p/MYD88 axis, offering new insights into the pathogenesis of UC.
genetics_knock down_promote	35412358	hsa-mir-143	Colorectal Neoplasms	3p inhibitor or overexpression rescues defects in cell invasion.
circulation_biomarker_diagnosis_ns	35412111	hsa-mir-193a	Autism Spectrum Disorder	The levels of EDNRA, SLC17A6, HTR3A, OSTC, TMEM165, PC-5p-139289_26, and hsa-miR-193a-5p were validated in at least 15 ASD and 15 TD individual serum samples, which were consistent with the results of transcriptome analysis.
other	35412062	hsa-mir-29	Postoperative Cognitive Complications	3p/CREB1/IL1RA axis.
lncRNA target	35411930	hsa-mir-497	Postoperative Cognitive Complications	CONCLUSIONS: Induction of miR-497 was involved in isoflurane anesthesia-induced cognitive impairment and neuronal cell apoptosis by targeting PLD1.
other	35411833	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	Therefore, OIP5-AS1 was upregulated to enhance the expression of oncogenic PD-L1 by sponging miR-34a in NSCLC, leading to promoted NSCLC cell proliferation. Our study also demonstrated that OIP5-AS1 was upregulated while miR-34a was downregulated in NSCLC.
other	35411716	hsa-mir-1290	Esophageal Squamous Cell Carcinoma	CONCLUSION: Our findings uncover an undescribed molecular mechanism, the circ_0001946/miR-1290/SOX6 ceRNA crosstalk, for the anti-ESCC activity of circ_0001946.
exosome	35411604	hsa-mir-184	Glioma	On the other hand, miR-3184 in glioma-derived exosomes polarizes macrophages to an M2-like phenotype, which further aggravates tumour progression.
exosome	35411299	hsa-mir-10a	Stomach Neoplasms	Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively.
exosome	35411299	hsa-mir-18a	Stomach Neoplasms	Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively.
exosome	35411299	hsa-mir-215	Stomach Neoplasms	Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively.
exosome	35411299	hsa-mir-19b	Stomach Neoplasms	Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively.
other	35411175	hsa-mir-770	Dmd-Associated Dilated Cardiomyopathy	3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM.
other	35411175	hsa-mir-363	Dmd-Associated Dilated Cardiomyopathy	3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM.
other	35411175	hsa-mir-551b	Dmd-Associated Dilated Cardiomyopathy	3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM.
lncRNA target	35410813	hsa-mir-570	Breast Neoplasms	CONCLUSION: MALAT1 functions as a novel oncogenic lncRNA in regulating the progression and doxorubicin resistance of BC by targeting miR
circRNA target	35410505	hsa-mir-31	Spinal Cord Injuries	Thus, our results suggested that in SCI pathogenesis, hsa_circ_0026646 correlates with PLXNB2 by targeting miR
lncRNA target	35410500	hsa-mir-497	Neurotoxicity Syndromes	In conclusion, our findings indicated that SNHG12 might relieve BV-associated neurotoxicity by upregulating NLRX1 via miR
target gene	35410355	hsa-mir-146a	Liver Neoplasms	MicroRNA-146a promotes proliferation, migration, and invasion of HepG2 via regulating FLAP.
other	35410298	hsa-mir-33a	Atrial Fibrillation	Taking into consideration both the ceRNA theory and inference scores from the comparative toxicogenomics database (CTD) database, the ceRNA axis FAM201A-miR-33a-3p-RAC3 was identified as mostly relevant to AF susceptibility.
other	35409311	hsa-mir-20b	Premature Birth	3p appeared just in PTB pregnancies.
other	35409311	hsa-mir-16	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-24	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-221	Premature Birth	3p appeared just in PTB pregnancies.
other	35409311	hsa-mir-92a	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-210	Premature Birth	3p was a common feature of PTB and PPROM pregnancies.
other	35409311	hsa-mir-145	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-126	Premature Birth	3p appeared just in PTB pregnancies.
other	35409311	hsa-mir-26a	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-133a	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-342	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-146a	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409311	hsa-mir-155	Premature Birth	3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR.
other	35409278	hsa-mir-338	Hemorrhagic Fever with Renal Syndrome	Decreased TA C-IV subunit expression in HFHS-S was reverted in HFHS-E, concomitantly with the downregulation of miR-338.
other	35409234	hsa-mir-483	Depressive Disorder, Major	A total of 228 miRNAs were significantly correlated with depressive symptoms improvements after 2 weeks of SSRIs treatment, with miR-483.5p showing the most robust correlation.
genetics_GWAS	35409153	hsa-mir-499a	Cardiomyopathy, Hypertrophic	Circulating miR-499a-5p Is a Potential Biomarker of MYH7-Associated Hypertrophic Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disease with significant genetic and phenotypic heterogeneity.
exosome	35409043	hsa-mir-130a	Triple Negative Breast Neoplasms	Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively.
exosome	35409043	hsa-mir-130a	Breast Neoplasms	Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively.
exosome	35409043	hsa-mir-576	Triple Negative Breast Neoplasms	Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively.
exosome	35409043	hsa-mir-576	Breast Neoplasms	Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively.
other	35409006	hsa-let-7c	Myopia, High	A miRNA-Array analysis revealed that let-7c was significantly up-regulated and miR-200a was significantly down-regulated in high myopic MH eyes compared to those in MH eyes.
other	35409006	hsa-mir-200a	Myopia, High	A miRNA-Array analysis revealed that let-7c was significantly up-regulated and miR-200a was significantly down-regulated in high myopic MH eyes compared to those in MH eyes.
lncRNA target	35408903	hsa-mir-326	Colorectal Neoplasms	In terms of mechanism, kaempferol promotes the expression of microRNA-326 (miR-326) in colon cancer cells, and miR-326 could inhibit the process of glycolysis by directly targeting pyruvate kinase M2 isoform (PKM2) 3'-UTR (untranslated region) to inhibit the expression of PKM2 or indirectly block the alternative splicing factors of PKM mRNA, and then reverse the resistance of colorectal cancer cells to 5-Fu.
lncRNA target	35408829	hsa-mir-125b	Leukemia	miRNAs with the highest number of MTIs were miR-125b-5p, miR5p, miR-181a-5p and miR-19a-3p, while target genes with the highest number of MTIs were TP53, BCL2, KIT, ATM, RUNX1 and ABL1.
lncRNA target	35408829	hsa-mir-155	Leukemia	miRNAs with the highest number of MTIs were miR-125b-5p, miR5p, miR-181a-5p and miR-19a-3p, while target genes with the highest number of MTIs were TP53, BCL2, KIT, ATM, RUNX1 and ABL1.
lncRNA target	35408691	hsa-mir-877	Pancreatic Carcinoma	(4) Conclusions: our findings indicate that rutin plays an important role in anti-pancreatic cancer effects through a rutin-miR
lncRNA target	35406786	hsa-mir-338	Adenocarcinoma of Lung	FAM111/ZWINT pathways as potential diagnostic biomarkers or therapeutic targets of LUAD.
circulation_biomarker_diagnosis_down	35406680	hsa-mir-146a	Bronchiolitis Obliterans	We observed a significant downregulation of circulating hsa-miR
circulation_biomarker_diagnosis_down	35406680	hsa-mir-1	Bronchiolitis Obliterans	We observed a significant downregulation of circulating hsa-miR
circulation_biomarker_diagnosis_down	35406680	hsa-mir-155	Bronchiolitis Obliterans	We observed a significant downregulation of circulating hsa-miR
lncRNA target	35406629	hsa-mir-29b-2	Colorectal Neoplasms	Our findings suggest that, LOC550643-miR-29b5p axis was determined to participate in the growth and metastasis of colon cancer cells; this could serve as a useful molecular biomarker for cancer diagnosis and as a potential therapeutic target for CRC.
transcription factor target	35406534	hsa-mir-214	Sarcoma, Ewing	3p is constitutively repressed by both EWS-FLI1 and CD99 because it acts as an oncosuppressor limiting the dissemination of EWS cells.
lncRNA target	35406446	hsa-mir-26b	Leukemia, Lymphocytic, Chronic, B-Cell	Specifically, up-regulation of miR-26b-5p in CLL cells blocks TGF-beta/SMAD pathway by down-modulation of SMAD-4, resulting in lower expression of p21(-Cip1) kinase inhibitor and higher expression of c-Myc oncogene.
lncRNA target	35406401	hsa-mir-139	Carcinoma, Hepatocellular	CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway.
target gene	35406397	hsa-mir-199a	Prostatic Neoplasms	Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway.
target gene	35406397	hsa-let-7a	Prostatic Neoplasms	Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway.
other	35406086	hsa-mir-551a	Carcinoma	The hsa-miR-551a upregulation, which has been linked to a reduced cell migration and invasion in several carcinomas, suggests a novel mechanism of walnuts in cancer risk.
circulation_biomarker_diagnosis_ns	35405462	hsa-mir-21	Lung Neoplasms	In addition, the feasibility is confirmed by performing the detection of miRNA-21 extracted from non-small cell lung cancer (NSCLC) A549 cells, and a good recovery is achieved in complex human serum sample.
lncRNA target	35405317	hsa-mir-21	Neuroblastoma	RESULTS: Downregulated expression of FOXO3a was observed in neuroblastoma cells, with a negative correlation between FOXO3a and miR-21 expression. CONCLUSIONS: In conclusion, FOXO3a may inhibit the progression of neuroblastoma by suppressing the miR-21 expression and facilitating SPRY2-dependent ERK pathway inactivation.
lncRNA target	35404759	hsa-mir-7-2	Endometrial Neoplasms	2-3p/DCLK1 axis contributes to the proliferation and metastasis of endometrial cancer cells via the PI3K/Akt/NF-kappaB pathway.
lncRNA target	35404727	hsa-mir-15a	Gallbladder Neoplasms	AFAP1-AS1 may regulate GBC cell proliferation and apoptosis via has-miR-15a-5p to mediate bcl-2 expression.
lncRNA target	35404476	hsa-mir-155	Asthma	However, no specific cell-intrinsic role has yet been elucidated for miR-155 in T cells in the course of Th2-eosinophilic and Th17-neutrophilic airway inflammation using actual in vivo asthma models. Conclusively, our data revealed that miR-155 could promote Th2 and Th17-mediated airway inflammation via the regulation of several different target genes, depending on the context of asthmatic diseases.
other	35404333	hsa-mir-1	Inflammatory Bowel Diseases	We confirmed miR-31, -106a, and -135b to be significantly deregulated between normal mucosa and dysplasia, as well as across the UC-associated CRC sequence (all P < 0.01).
circulation_biomarker_diagnosis_ns	35404278	hsa-mir-34c	hypoglycemic encephalopathy	The serum levels of miR-34c were increased in patients with DE comparing with normal controls.
circulation_biomarker_diagnosis_ns	35404278	hsa-mir-34c	Diabetic Neuropathies	The serum levels of miR-34c were increased in patients with DE comparing with normal controls.
genetics_knock down_suppress	35404176	hsa-mir-16	Rhinitis, Allergic	5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction.
genetics_overexpression_promote	35403775	hsa-mir-107	Squamous Cell Carcinoma of Head and Neck	miR-107 directly targeted the 3' untranslated region of FZD4, and FZD4 overexpression largely reversed the anti-tumor effects of circ_0001971 in OSCC cells.
other	35402824	hsa-mir-214	Anemia, Aplastic	Abnormal miR-214/A20 expression might play a role in T cell activation in patients with aplastic anemia.
other	35402661	hsa-mir-20a	Heart Failure	RESULTS: Expression of miRNA-320a was up-regulated while RUNX2 expression was down-regulated in TIONFH than Normal control.
other	35402587	hsa-mir-206a	Glioma	Validated by Chinese Glioma Genome Atlas and our LGG patients of gene expression and survival, and the colorectal neoplasia differentially expressed (CRNDE), HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1)/miRNA-206a/hepatocyte nuclear factor 4 (HNF4G) axis was determined.
exosome	35402583	hsa-mir-432	late onset Parkinson's disease	This study was designed to investigate if there is a correlation between PDE exosomal miRNA (miR
circulation_biomarker_diagnosis_up	35402577	hsa-mir-21	Crohn Disease	RESULTS: Our data revealed that the circulating exosomes of patients with CD have a remarkable effect on the proliferation and migration of human umbilical vein endothelial cells (HUVECs), and that exosomal miR-21 levels were highly elevated in exosomes derived from the plasma of CD patients.
other	35402537	hsa-mir-16	Ventricular Remodeling	Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients.
other	35402537	hsa-mir-21	Ventricular Remodeling	Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients.
other	35402537	hsa-mir-29a	Ventricular Remodeling	Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients.
other	35402517	hsa-mir-141	Carcinoma, Renal Cell	In summary, our results demonstrate the oncogenic role of FAM13A-AS1 in RCC and suggest that it promotes tumorigenesis by upregulating the expression of NEK6 by competitively binding to miR3p.
other	35402226	hsa-mir-216	Glioma	In summary, our study shows that the HOXC-AS3/miR-216/F11R axis plays an important role in the malignant progression of glioma, and may provide new ideas for the treatment of glioma.
lncRNA target	35402187	hsa-mir-150	Nasopharyngeal Carcinoma	CONCLUSIONS: The progression of NPC tumors is facilitated by lncRNA IGBP1-AS1 via miR5p and regulates ZEB1 expression.
lncRNA target	35402183	hsa-mir-595	Carcinoma, Non-Small-Cell Lung	Additionally, we demonstrated that circPTN upregulated LYRM5 expression by sponging miR-595, which promoted NSCLC angiogenesis in NSCLC. CONCLUSIONS: We found that circPTN serves as a competing endogenous ribonucleic acid that promotes angiogenesis via the miR-595/LYRM5 signaling pathway in NSCLC.
target gene	35402178	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	LncRNA B4GALT1-AS1 promotes non-small cell lung cancer cell growth via increasing ZEB1 level by sponging miR-144-3p.
transcription factor target	35402074	hsa-mir-130b	Diabetic Nephropathies	Additionally, the inhibition of miR-130b-3p with an antagomir in vivo effectively enhanced glomerular podocyte injury and mitotic dysfunction, eventually exacerbating proteinuria.
lncRNA target	35402073	hsa-mir-25	Femur Head Necrosis	Results showed that circHGF suppressed the proliferation and osteogenic differentiation of BMSCs in ONFH by targeting miR3p/SMAD7 axis.
circulation_biomarker_diagnosis_ns	35401927	hsa-mir-206	Cardiomyopathy, Hypertrophic	ACTB, miR-206, circFN1, and ADAMTS9-AS1 expression in peripheral blood samples from HCM patients and normal healthy controls were detected using RT-qPCR.
other	35401881	hsa-mir-4713	Pediatric Obesity	The expression of GATA3, miR-452, and miR-4713 was also significantly lower in the obesity and the obesity with fracture groups when compared to the NC group. Therefore, NPY1R, TCF4, HEY1, GATA3, miR-452, and miR-4713 may be risk factors for fracture in obese children.
other	35401881	hsa-mir-452	Pediatric Obesity	The expression of GATA3, miR-452, and miR-4713 was also significantly lower in the obesity and the obesity with fracture groups when compared to the NC group. Therefore, NPY1R, TCF4, HEY1, GATA3, miR-452, and miR-4713 may be risk factors for fracture in obese children.
genetics_overexpression_promote	35401845	hsa-mir-525	Colorectal Neoplasms	5p could be sponged by circ_0000423, and its overexpression also abolished the regulation of circ_0000423 on the progression of SEV-treated CRC cells.
lncRNA target	35401844	hsa-mir-625	Carcinoma, Hepatocellular	CONCLUSION: LINC00852 regulates HCC cell activities via the miR-625/E2F1 axis.
other	35401746	hsa-mir-4713	Squamous Cell Carcinoma of Head and Neck	Bioinformatics analysis revealed that miR3p is a key miRNA of EPHX3 in HNSCC.
circulation_biomarker_prognosis_up	35401744	hsa-mir-13	Leukemia, Promyelocytic, Acute	CONCLUSION: Serum miR
circulation_biomarker_prognosis_up	35401744	hsa-mir-126	Leukemia, Promyelocytic, Acute	CONCLUSION: Serum miR
other	35401696	hsa-mir-376c	Esophageal Neoplasms	3p/YTHDF1 axis, respectively.
other	35401696	hsa-mir-655	Esophageal Neoplasms	3p/YTHDF1 axis, respectively.
other	35401675	hsa-mir-16	Amelogenesis Imperfecta	Thus, our study shows that miR5p and miR-27b-3p are candidate pathogenic miRNAs for amelogenesis imperfecta.
other	35401675	hsa-mir-27b	Amelogenesis Imperfecta	Thus, our study shows that miR5p and miR-27b-3p are candidate pathogenic miRNAs for amelogenesis imperfecta.
other	35401659	hsa-mir-125b	Ischemic Stroke	We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells.
other	35401659	hsa-mir-148b	Ischemic Stroke	We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells.
other	35401659	hsa-mir-125a	Ischemic Stroke	We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells.
transcription factor target	35401251	hsa-mir-124	Morphine Dependence	CONCLUSION: MiR-124 and its target protein IQGAP1 are involved in the regulation of addiction and cognitive function in patients with morphine dependence.
other	35401251	hsa-mir-124	Cognition Disorders	The level of miR-124 was an independent factor influencing the severity of cognitive impairment in patients with morphine dependence.
other	35401251	hsa-mir-124	Osteoarthritis	MiR-124, IQGAP1, the average intake last year were related to OASI scores.MiR-124, IQGAP1, PHQ-9 were associated with MOCA scores.
epigenetics	35401185	hsa-mir-27	lung squamous cell carcinoma	In addition of inhibiting activation of the Notch pathway by repressing methylation of the miR
exosome	35401112	hsa-let-7a	Spinal Cord Injuries	Further study found that let-7a-5p exerted a similar biological effect as MSC-EVs in regulating the differentiation of NSCs and leading to neurological improvement in SCI rats. In conclusion, MSC-EV-secreted let-7a-5p promoted the regrowth of neurons and improved neurological recovery in SCI rats by targeting the HMGA2/SMAD2 axis.
circulation_biomarker_diagnosis_up	35400999	hsa-mir-126	Myocardial Infarction	We demonstrated that exosomes from the peripheral serum of AMI patients promote angiogenesis via the miR
other	35400282	hsa-mir-205	Colorectal Neoplasms	This study demonstrated that the circ_0007331/miR5p/HMGA2 axis promotes CRC development.
genetics_overexpression_promote	35400275	hsa-mir-184	Carcinoma, Hepatocellular	Mechanistically, miR-184 could be sponged by circITCH, and its overexpression could mitigate the suppressive effects of circITCH overexpression on HCC progression. Our findings reveal that circITCH served as a repressor to restrain HCC malignancy via miR-184.
circRNA target	35400271	hsa-mir-421	Carcinoma, Hepatocellular	Silencing circSEC24A mitigated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, which was abrogated by downregulation of miR-421. circSEC24A interference suppressed HCC cell EMT by sponging miR-421, further regulating MMP3, and inhibiting tumor growth in vivo.
genetics_overexpression_promote	35399733	hsa-mir-188	Pancreatic Carcinoma	Besides, overexpression of miR
genetics_knock down_promote	35399726	hsa-mir-454	Wilms Tumor	3p was identified as the reason of WTX loss in HCC.
genetics_knock down_promote	35399726	hsa-mir-454	Carcinoma, Hepatocellular	3p was identified as the reason of WTX loss in HCC.
target gene	35399723	hsa-mir-216a	Uterine Cervical Neoplasms	LncRNA HCP5 enhances the proliferation and migration of cervical cancer via miR-216a-5p/CDC42 axis.
other	35399713	hsa-mir-338	Osteosarcoma	KLF9 regulates miR-338-3p/NRCAM axis to block the progression of osteosarcoma cells.
other	35399708	hsa-mir-339	Adenocarcinoma of Lung	Taken together, our results uncovered a Uc.339/miR-339/SLC7A11 axis that leads to defects in the ferroptosis in lung cancer, and constitutes a potential mechanism that drives the metastasis of lung adenocarcinoma.
exosome	35399607	hsa-mir-760	Breast Neoplasms	Next, ARF6 was confirmed as a target gene of miR-760 in exosomes derived from CCL18-stimulated high metastatic BC cells. Together, our results support that exosomal miR-760 secreted by CCL18-stimulated high metastatic BC cells promoted the malignant behaviors in low metastatic BC cells by up-regulating the ARF6-mediated Src/PI3K/Akt signaling pathway.
other	35399604	hsa-let-7b	Carcinoma, Ovarian Epithelial	Decrease in Let7b miRNA levels in clinical ovarian cancer has been associated with chemoresistance, increased proliferation, invasion, and relapse in EOC. We demonstrate that a therapeutic combination of Let7b miRNA and PTX leads to significant improvement in anti-tumor efficacy in the relapsed model of EOC.
lncRNA target	35399564	hsa-mir-1184	Adenocarcinoma of Lung	Furthermore, circP4HB protects LUAD from ferroptosis via modulation of the miR-1184/SLC7A11 axis.
genetics_overexpression_promote	35399330	hsa-mir-217	Breast Neoplasms	5p overexpression may inhibit cell migration, invasion, the EMT and NF-kappaB signaling pathway in BC via targeting of MTDH.
other	35399328	hsa-mir-1	Colorectal Neoplasms	5p-DMD axis may serve as a novel biomarker in predicting the development of SEOCRC, and DMD can be used as a promising biomarker for the prognosis of SEOCRC.
genetics_overexpression_promote	35399229	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	5p inhibitor or BCLCL2-overexpression reversed LINC00152 siRNA-induced NSCLC cell growth inhibition.
circulation_biomarker_diagnosis_up	35399150	hsa-mir-21	Breast Neoplasms	Regarding the early stages of BC, the median levels of the fold change of serum miR21 and miR10b were statistically significantly higher in patients with BC (stages I and IIa) than in the control group (P < 0.001).
circulation_biomarker_diagnosis_up	35399150	hsa-mir-10b	Breast Neoplasms	Regarding the early stages of BC, the median levels of the fold change of serum miR21 and miR10b were statistically significantly higher in patients with BC (stages I and IIa) than in the control group (P < 0.001).
lncRNA target	35399101	hsa-mir-145	Endometriosis	Furthermore, erastin-induced ferroptosis shrunk endometriotic lesions via the MALAT1/miR5p/MUC1 axis in vivo.
other	35399100	hsa-mir-140	Osteoarthritis	CONCLUSION: To sum up, this study showed that PVT1 promoted expressions of ADAMTS-5 and MMP-13 as a competing endogenous RNA (ceRNA) of miR-140 in OA, which eventually led to aggravation of ECM degradation, thus providing a new and promising strategy for the treatment of OA.
lncRNA target	35399076	hsa-mir-195	Adenocarcinoma of Lung	CONCLUSION: Silencing LINC00511 promotes GCNT3 expression by inhibiting miR
lncRNA target	35399004	hsa-mir-183	Nonsyndromic Deafness	The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96.
lncRNA target	35399004	hsa-mir-182	Nonsyndromic Deafness	The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96.
lncRNA target	35399004	hsa-mir-96	Nonsyndromic Deafness	The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96.
genetics_knock down_suppress	35398813	hsa-mir-145	Biliary Atresia	This work validated that ligustrazine-regulated miR-145 mediated TGF-beta/Smad signaling to inhibit the progression of liver fibrosis in a biliary atresia rat model and provided a new therapeutic strategy for liver fibrosis. In addition, overexpression and knockdown of miR-145 confirmed that miR-145 is involved in the ligustrazine inhibition of liver fibrosis through the TGF-beta/SMAD signaling pathway.
genetics_knock down_suppress	35398813	hsa-mir-145	Liver Cirrhosis	This work validated that ligustrazine-regulated miR-145 mediated TGF-beta/Smad signaling to inhibit the progression of liver fibrosis in a biliary atresia rat model and provided a new therapeutic strategy for liver fibrosis. In addition, overexpression and knockdown of miR-145 confirmed that miR-145 is involved in the ligustrazine inhibition of liver fibrosis through the TGF-beta/SMAD signaling pathway.
lncRNA target	35398468	hsa-mir-34a	Prostatic Neoplasms	In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
lncRNA target	35398468	hsa-mir-155	Prostatic Neoplasms	In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
lncRNA target	35398468	hsa-mir-21	Prostatic Neoplasms	In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
lncRNA target	35398468	hsa-mir-150	Prostatic Neoplasms	In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
lncRNA target	35398468	hsa-mir-19a	Prostatic Neoplasms	5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
lncRNA target	35398468	hsa-mir-23b	Prostatic Neoplasms	5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples.
transcription factor target	35398394	hsa-mir-125a	Diabetic Neuropathies	Non-DN patients had significantly lower expression levels of miR-125a-5p, SEMA4D, ATG14, and ATG16L1 compared to the HC. Dysregulated expression of SEMA4C, PLXNB2, and ATG16L1, targeted by miR-19b-3p and miR-125a-5p, showed that they probably play a role in the DN development.
transcription factor target	35398208	hsa-mir-29a	Carcinoma, Adenoid Cystic, Lacrimal Gland	Current studies have identified differentially expressed miRNAs associated with LACCs of variable proliferation ability, and found that AKT2 is a direct target gene of miR-29a-3p, which will contribute to target gene therapy in patients with high proliferation LACC in the future.
lncRNA target	35398178	hsa-mir-2113	Glioblastoma	To conclude, circPOLR2A enhanced the transcription of SOX9 through miR-2113/POU3F2 axis, thus exacerbating GBM cells growth.
lncRNA target	35398161	hsa-mir-221	Parkinson Disease	In conclusion, HOTAIR attenuated the injury of SH-SY5Y cells induced by MPP(+) via miR
genetics_overexpression_promote	35397570	hsa-mir-143	Diabetes Mellitus, Type 2	While miR-143 was overexpressed in the SAT of obese and morbidly obese individuals compared to the normal-weight group, the pairwise comparison showed no significant difference in the miR-34a expression of SAT between the four BMI groups (P>0.01).
genetics_overexpression_promote	35397570	hsa-mir-34a	Diabetes Mellitus, Type 2	While miR-143 was overexpressed in the SAT of obese and morbidly obese individuals compared to the normal-weight group, the pairwise comparison showed no significant difference in the miR-34a expression of SAT between the four BMI groups (P>0.01). A negative association was observed between the VAT PPARgamma expression and miR-34a expression in obese cases (beta = - 0.594, P=0.039).
lncRNA target	35397427	hsa-mir-142	Obesity	Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats.
lncRNA target	35397427	hsa-mir-495	Burns	Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats.
lncRNA target	35397427	hsa-mir-495	Obesity	Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats.
lncRNA target	35397427	hsa-mir-142	Burns	Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats.
transcription factor target	35397366	hsa-mir-636	Osteoporosis	CONCLUSIONS: In summary, this paper proposed that IRF4/miR-636/DOCK9 may be considered as targets for the treatment of osteoporosis (OP).
transcription factor target	35397366	hsa-mir-636	Osteoporosis-pseudoglioma syndrome	CONCLUSIONS: In summary, this paper proposed that IRF4/miR-636/DOCK9 may be considered as targets for the treatment of osteoporosis (OP).
genetics_overexpression_promote	35397087	hsa-mir-211	Squamous Cell Carcinoma of Head and Neck	3p overexpression (OE) group was significantly higher than negative control (NC) group treated with paclitaxel, suggesting miR
exosome	35397056	hsa-mir-148a	Atrial Fibrillation	In our study, exosomes derived from BMSCs inhibited the development of AF, and miR-148a acted a vital role in this segment.
genetics_knock down_promote	35397054	hsa-mir-613	Carcinoma, Non-Small-Cell Lung	The loss-of-functional experiments suggested that knockdown of circFAM126A suppressed proliferation, migration and invasion, as well as caused apoptosis and cell cycle arrest in NSCLC cells, which was abolished by silencing of miR-613.
circRNA target	35397013	hsa-mir-548b	Colorectal Neoplasms	has_circ_0001944 downregulation can slow the progression of CRC partly by targeting miR-548b-3p.
lncRNA target	35396910	hsa-mir-98	Asthma	In conclusion, ANRIL indirectly up-regulates CCND1 expression by targeting miR5p to promote ASMC proliferation, migration and ECM deposition, thus facilitating the pathogenesis of asthma.
exosome	35396771	hsa-mir-24	Carcinoma, Hepatocellular	Collectively, we revealed that exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes the progression of HCC by inducing Tregs expansion via regulating the miR5p/TGFBR1/Smad3 axis.
circRNA target	35396749	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ_0011298 elevated Taxol resistance of NSCLC by sponging miR3p and upregulating CRABP2, providing a possible circRNA-targeted therapy for NSCLC.
genetics_knock down_suppress	35396504	hsa-mir-140	Urinary Bladder Neoplasms	Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR3p/FOXQ1 signaling, suggesting that hsa_circRNA_0088036 is a potential biomarker and therapeutic target for BCa.
circulation_biomarker_diagnosis_up	35395980	hsa-mir-424	Multiple Myeloma	CONCLUSION: The serum levels of miR-424 and miR-765 in MM patients are significantly increased in the pattern increasing with the progression of MM stage.
circulation_biomarker_diagnosis_up	35395980	hsa-mir-765	Multiple Myeloma	CONCLUSION: The serum levels of miR-424 and miR-765 in MM patients are significantly increased in the pattern increasing with the progression of MM stage.
other	35395974	hsa-mir-211	Acute Lymphoblastic Leukemia, T-Cell	CONCLUSION: The expressions of miR-211, miR-155, and C-myc are up-regulated in T-ALL patients, closely related to prognosis, and linearly positively correlated with disease risk.
other	35395974	hsa-mir-155	Acute Lymphoblastic Leukemia, T-Cell	CONCLUSION: The expressions of miR-211, miR-155, and C-myc are up-regulated in T-ALL patients, closely related to prognosis, and linearly positively correlated with disease risk.
lncRNA target	35395973	hsa-mir-155	Acute Lymphoblastic Leukemia, B-Cell	RESULTS: Compared with normal tissues and cells, the expression level of miR-155 in B-ALL bone marrow tissue/cell line was increased (P&lt;0.05); Compared with drug sensitive B-ALL tissues/cell lines, the expression level of miR-155 in drug resistant B-ALL tissues and cell lines was increased (P&lt;0.05); Inhibition of miR-155 expression decreased the proliferation of REH/Ara-C cells (P&lt;0.05), promoted apoptosis (P&lt;0.05), enhanced the cytotoxicity of Ara-C (P&lt;0.05), and inhibited Wnt/-Catenin signaling pathway related protein and MDR1 gene expression (P&lt;0.05), which could be reversed by activating Wnt expression (P&lt;0.05).
other	35395969	hsa-mir-217	Leukemia	OBJECTIVE: To explore the effect of carvacrol on the biological behavior of leukemia cells and its regulation to circ-0008717/miR-217 molecular axis. CONCLUSION: Carvacrol can promote the expression of miR-217 by down-regulating the expression of circ-0008717, thereby reducing the proliferation and cloning ability of leukemia cells and promoting cell apoptosis.
lncRNA target	35395756	hsa-mir-30	Urinary Bladder Neoplasms	Expression profiles of miR-330 targets in BC cells were assessed via western blotting.
lncRNA target	35395550	hsa-mir-214	Leukemia, Myeloid, Acute	This study showed that hsa-miR3p-regulates aberrant lipolysis by promoting ATGL expression, which causes AML progression through the PPARalpha pathway.
circulation_biomarker_diagnosis_ns	35395459	hsa-mir-223	Inflammatory Bowel Diseases	Herein, we established a fluorescent probe for ulcerative colitis (UC) activity-associated two serum biomarkers (miR-23a and miR-223) simultaneous detection, which used multi-color fluorescent DNA-stabilized silver nanoclusters (DNA-AgNC) illuminated by a close guanine (G)-rich sequence as a signal transducer and two split DNA probes as recognition units.
circulation_biomarker_diagnosis_ns	35395459	hsa-mir-23a	Inflammatory Bowel Diseases	Herein, we established a fluorescent probe for ulcerative colitis (UC) activity-associated two serum biomarkers (miR-23a and miR-223) simultaneous detection, which used multi-color fluorescent DNA-stabilized silver nanoclusters (DNA-AgNC) illuminated by a close guanine (G)-rich sequence as a signal transducer and two split DNA probes as recognition units.
genetics_overexpression_promote	35395444	hsa-mir-432	Stomach Neoplasms	5p overexpression counteracted the promoting effect of circ_0075825 on the malignancy of GC cells.
exosome	35394683	hsa-mir-184	Stomach Neoplasms	Exosome miR-3184-5p inhibits gastric cancer growth by targeting XBP1 to regulate the AKT, STAT3, and IRE1 signalling pathways.
genetics_overexpression_promote	35394639	hsa-mir-320d	Colorectal Neoplasms	Interference with miR-320d or overexpression of c-Myc reversed the increased chemotherapeutic sensitivity of CRC-SCs induced by synergistic therapy with 5-FU and MR. In conclusion, the combined chemotherapy with MR can enhance the chemotherapeutic sensitivity of CRC-SCs by up-regulation of miR-320d to inhibit c-Myc expression, which lays a molecular basis for MR regulation of chemotherapeutic sensitivity of CRC-SCs.
genetics_knock down_suppress	35394558	hsa-mir-638	Glioma	SZRD1 was a target of miR-318, and its overexpression overturned the inhibition effect of miR-638 mimic on glioma progression and angiogenesis.
lncRNA target	35394175	hsa-mir-1229	Breast Neoplasms	3p, and it inhibited tumor growth of BC in vivo by mediating the miR
other	35393569	hsa-mir-122	Rift Valley Fever	To enhance specificity of NSs for use in hepatocellular carcinoma, we incorporated four miR-122 binding sites in the 3' untranslated region (UTR) of the NSs mRNA to achieve cell type specific expression.
other	35393513	hsa-mir-16	Urinary Bladder Neoplasms	3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker.
other	35393513	hsa-mir-335	Urinary Bladder Neoplasms	3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker.
other	35393513	hsa-mir-124	Urinary Bladder Neoplasms	3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker.
other	35393513	hsa-let-7b	Urinary Bladder Neoplasms	3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker.
circulation_biomarker_diagnosis_ns	35393236	hsa-mir-206	Muscular Dystrophies	3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR
circulation_biomarker_diagnosis_ns	35393236	hsa-mir-363	Muscular Dystrophies	3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR
circulation_biomarker_diagnosis_ns	35393236	hsa-mir-223	Muscular Dystrophies	3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR
circulation_biomarker_diagnosis_ns	35393236	hsa-mir-143	Muscular Dystrophies	3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR
circulation_biomarker_diagnosis_ns	35393236	hsa-mir-25	Muscular Dystrophies	3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR
circulation_biomarker_diagnosis_up	35392987	hsa-mir-506	Diabetic Nephropathies	3p was downregulated in the serum of DN patients and HG-induced HK-2 cells.
exosome	35392967	hsa-mir-466f	Fibrosis, Renal	CONCLUSIONS: Our findings indicated that exosomal miR-466f-3p derived from mMSCs may possess anti-fibrotic properties and prevent radiation-induced EMT through inhibition of AKT/GSK3beta via c-MET, providing a promising therapeutic modality for radiation-induced lung fibrosis.
circulation_biomarker_diagnosis_up	35392782	hsa-mir-140	Pneumonia	RESULTS: LncRNA H19 and TLR4 were up-regulated, while miR5p was downregulated in peripheral blood of patients with pneumonia and LPS-treated WI-38 cells compared with their controls.
lncRNA target	35392747	hsa-mir-214	Cataract	CONCLUSION: Circ_0060640 is a novel cataract-related gene and its silencing could block TGF-beta2-evoked hLECs proliferation, motility and EMT in vitro via targeting miR3p-COL1A2 axis.
other	35392075	hsa-mir-27a	Urinary Bladder Neoplasms	Competing endogenous RNA network analysis suggested that lncRNA AC107027.3 may upregulate FASN by competitively binding miR-27A-3p, thereby regulating the immunotherapy response in BC.
other	35392023	hsa-mir-148a	Pulmonary Disease, Chronic Obstructive	The expression of CXCR1, HBEGF, TREM-1, and hsa-miR-148a-3p was more elevated in patients with COPD than in normal controls, whereas NFAT5 was decreased.
genetics_overexpression_promote	35391781	hsa-mir-543	Ovarian Neoplasms	Furthermore, the overexpression of miR-543 resulted in the suppression of OvCa cell proliferation in vitro and in vivo.
genetics_overexpression_suppress	35391656	hsa-mir-432	Uterine Cervical Neoplasms	Besides, overexpressed MCL1 also could reverse the enhancing effect of miR
other	35391605	hsa-mir-208b	Wounds and Injuries	RESULTS: Circ_0001445 and ABCG1 were decreased, and miR-208b-5p was increased in CAD patients and ox-LDL-treated HAECs. CONCLUSION: Circ_0001445 could abate ox-LDL-mediated HAEC damage by the miR-208b-5p/ABCG1 axis, providing a novel insight into the pathogenesis and treatment of CAD.
lncRNA target	35390275	hsa-mir-10b	Glioma	We demonstrate that the entire miR-10b-hosting HOXD locus is activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping.
circRNA target	35389936	hsa-mir-1305	Uterine Cervical Neoplasms	Finally, miR-1305 could target CREBRF, and circ_0009035 could regulate CREBRF expression by targeting miR-1305, thereby affecting cervical cancer tumorigenesis. In summary, our study confirmed that circ_0009035 could influence the development of cervical cancer through the targeted regulation of miR-1305/CREBRF.
genetics_knock down_suppress	35388975	hsa-mir-512	Carcinoma, Non-Small-Cell Lung	CORO1C overexpression largely reversed miR
genetics_knock down_promote	35388952	hsa-mir-16	Uterine Cervical Neoplasms	CONCLUSION: Knockdown of DLG1-AS1 promoted GEM sensitivity in cervical cancer cells by regulating miR
transcription factor target	35388757	hsa-mir-16	Glioblastoma	CONCLUSIONS: MT inhibits the malignant progression of GBM via regulating miR5p-mediated PIM1.
circulation_biomarker_diagnosis_up	35388602	hsa-mir-181b	Tuberculosis	In addition, miR-181b-5p is significantly up-regulated in the peripheral blood plasma of tuberculosis patients, which has a high diagnostic value (AUC = 0.969).
genetics_overexpression_suppress	35388387	hsa-mir-4732	Adenocarcinoma of Lung	5p significantly inhibits the migration, invasion, and metastasis of LUAD in vitro and in vivo, which can be reversed by overexpression of XPR1.
circulation_biomarker_diagnosis_ns	35388333	hsa-mir-181b	Angelman Syndrome	RESULTS: In human AS serum and ox-LDL-induced VSMCs, circ_TNPO1 was increased, whereas miR-181b was decreased.
epigenetics	35388129	hsa-mir-148a	Adenocarcinoma of Lung	In the LUAD cell lines and tumor tissues from patients, miR-148a-3p was found to be significantly downregulated, while the methylation of miR-148a-3p promoter was notably increased.
transcription factor target	35387564	hsa-mir-26a	Carcinoma, Hepatocellular	In summary, our findings uncover a novel mechanism behind the anti-tumor effects of emodin that regulates M2 polarization via miR-26a/TGF-beta1/Akt to suppress HCC growth.
genetics_overexpression_promote	35387554	hsa-mir-19a	pancreatic adenocarcinoma	Overexpression of circ-MYBL2 decreased PA cell proliferation and movement, while overexpression of miR-19a showed an opposite effect.
genetics_overexpression_promote	35387544	hsa-mir-378	Rhinitis, Allergic	Moreover, overexpression of CCL5 reversed miR-378g-induced effects.Conclusion: In conclusion, depletion of JP X promoted Treg/Th17 balance in AR via regulating the miR-378g/CCL5 axis.
genetics_overexpression_suppress	35386623	hsa-mir-23a	Sepsis	HMGB1 expression was increased and miR-23a-3p expression significantly reduced in patients with sepsis and in LPS-treated RAW264.7 cells in comparison with controls. miR-23a-3p is expressed at reduced levels during inflammation in sepsis, and overexpression of miR-23a-3p inhibits LPS-induced inflammation in murine macrophages in vitro by directly downregulating HMGB1.
other	35386538	hsa-mir-335	Mandibulofacial Dysostosis	Furthermore, from the regulatory level perspective, TNC could be significantly impressed by miR5p.
other	35386454	hsa-mir-150	Multiple Myeloma	Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS(2) (QD-MB @MoS(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150.
other	35386454	hsa-mir-155	Multiple Myeloma	Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS(2) (QD-MB @MoS(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150.
lncRNA target	35386284	hsa-mir-150	Carcinoma, Hepatocellular	The ceRNA network is expected to provide potential biomarkers and therapeutic targets for HCC management, especially the ZFAS1/hsa-miR5p/GINS1 regulatory axis.
genetics_GWAS	35386109	hsa-mir-449b	Diabetes Mellitus	The present study revealed an association between miR-27a A>G and miR-449b A>G polymorphisms and the risk of DM in Koreans, which suggests that these gene polymorphisms could represent potential markers for predicting T2DM risk.
genetics_overexpression_promote	35386035	hsa-mir-146b	Glioma	Overexpression of miR-146b-5p partly reversed the effects of circ_VCAN in Sev-treated glioma cells.
other	35385896	hsa-mir-9	Atrial Fibrillation	OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation.
other	35385896	hsa-mir-142	Atrial Fibrillation	OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation.
transcription factor target	35385779	hsa-mir-135a	Parkinson Disease	On the whole, the miR-135a-5p/Mst1 axis might serve as a potential therapeutic target in PD treatment.
other	35385711	hsa-mir-96	Sepsis	CONCLUSIONS: Down-regulation of lncRNA ZFAS1 attenuated LPS-induced ALI in HSAECs by regulating the miR5p/OXSR1 axis.
other	35385711	hsa-mir-96	Acute Lung Injury	CONCLUSIONS: Down-regulation of lncRNA ZFAS1 attenuated LPS-induced ALI in HSAECs by regulating the miR5p/OXSR1 axis.
circulation_biomarker_diagnosis_down	35384929	hsa-mir-199a	Cervical Cancer, Hpv Infected	Serum circMTO1 and miR-199a expressions were detected by reverse transcription-quantitative polymerase chain reaction, and the diagnostic efficacy of circMTO1 for CC and HR-HPV infection was analyzed by the receiver operating characteristic curve. Serum miR-199a was downregulated in HR-HPV-positive CC patients and inversely correlated with circMTO1.
circulation_biomarker_diagnosis_down	35384929	hsa-mir-199a	Uterine Cervical Neoplasms	Serum circMTO1 and miR-199a expressions were detected by reverse transcription-quantitative polymerase chain reaction, and the diagnostic efficacy of circMTO1 for CC and HR-HPV infection was analyzed by the receiver operating characteristic curve. Serum miR-199a was downregulated in HR-HPV-positive CC patients and inversely correlated with circMTO1.
other	35384910	hsa-mir-26	Coronary Artery Disease	Downregulation of circLDLR was associated with increased miR5p in coronary artery disease tissues.
genetics_knock down_suppress	35384084	hsa-mir-206	Glioma	circTCF25 was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reverses the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells. In summary, our findings demonstrate that the circTCF25/miR-206/CypB axis plays a vital role in glioma progression, migration, invasion, and tumorigenesis.
other	35383130	hsa-mir-885	Breast Neoplasms	3p to regulate the NTRK2/PIK3CA/AKT axis.
circRNA target	35382824	hsa-mir-579	Carcinoma, Hepatocellular	Circ_0036412 up-regulates GLI2 expression by competitively binding to miR3p, thus promoting the proliferation and inhibiting cell cycle arrest of HCC cells.
other	35382692	hsa-mir-4723	Triple Negative Breast Neoplasms	QRT PCR showed that the expression of hsa-mir5p was down regulated in TNBC cell line MDA-MB-231 with low expression of c-myc, which was positively correlated with the expression.
other	35382622	hsa-mir-514a	Angelman Syndrome	CONCLUSIONS: Our study stated the vital role of the hsa_circ_0030042/miR-514a-3p/FOXO1 axis and provides a profound understanding about the circRNA in AS.
circulation_biomarker_diagnosis_ns	35382374	hsa-mir-142	Fibromyalgia	Only plasma levels of miR-320a, miR-320b, and miR
circulation_biomarker_diagnosis_ns	35382172	hsa-mir-144	Crohn Disease	RESULTS: A 3.33-fold increase in serum exosomal miR
other	35381856	hsa-mir-214	Fatty Liver, Alcoholic	LncRNA UCA1 regulated the biological behavior of ethanol-induced L02 cells by sponging miR-214, which may provide novel therapeutic strategies for alcoholic fatty liver.
other	35381789	hsa-mir-2117	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
other	35381789	hsa-mir-2115	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-548q	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC.
other	35381789	hsa-mir-449c	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
other	35381789	hsa-mir-2114	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC.
other	35381789	hsa-mir-2115	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-449c	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
other	35381789	hsa-mir-2117	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-2117	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
other	35381789	hsa-mir-2115	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-449c	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-2114	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-2114	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC.
other	35381789	hsa-mir-548q	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC.
other	35381789	hsa-mir-2116	Carcinoma, Squamous Cell	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
other	35381789	hsa-mir-548q	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-2116	Granuloma	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples.
other	35381789	hsa-mir-2116	Pfeiffer type acrocephalosyndactyly	Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases.
circulation_biomarker_diagnosis_up	35381590	hsa-mir-4639	Glomerulonephritis, IGA	With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN.
circulation_biomarker_diagnosis_up	35381590	hsa-mir-210	Glomerulonephritis, IGA	With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN.
lncRNA target	35381577	hsa-mir-216a	Osteoporosis, Postmenopausal	The lncMIAT/miR-216a/p38MAPK signaling contributed predominantly to the increased inflammatory cytokine secretion in the PBMCs from postmenopausal osteoporosis. lncMIAT/miR-216a axis was critical for the regulation of AMPK/p38MAPK signaling, which may be a promising therapeutic target for osteoporosis treatment by inflammatory cytokine inhibition.
other	35381488	hsa-mir-103	Langer mesomelic dysplasia	It has been reasonably hypothesized that miR-103 may play a crucial role, which regulate skeletal muscle development of LMB.
circulation_biomarker_diagnosis_ns	35381457	hsa-mir-155	Breast Neoplasms	Here, a biosensor based on surface enhanced Raman spectroscopy (SERS) combined with catalytic hairpin assembly (CHA) amplification technology was developed for ultra-sensitive detection of miRNA-21 and miRNA-155 in breast cancer serum.
circulation_biomarker_diagnosis_ns	35381457	hsa-mir-21	Breast Neoplasms	Here, a biosensor based on surface enhanced Raman spectroscopy (SERS) combined with catalytic hairpin assembly (CHA) amplification technology was developed for ultra-sensitive detection of miRNA-21 and miRNA-155 in breast cancer serum.
other	35381016	hsa-mir-628	COVID-19	5p) independently classifies COVID-19 cases with 100% accuracy.
other	35381016	hsa-mir-93	COVID-19	5p) independently classifies COVID-19 cases with 100% accuracy.
exosome	35380635	hsa-mir-23b	salivary gland adenoid cystic carcinoma	We investigated the effect of exosomal miR-23b-3p on the progression of SACC.
genetics_knock down_suppress	35380509	hsa-mir-532	Ovarian Neoplasms	Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner.
other	35380290	hsa-mir-140	Hypoxia-Ischemia, Brain	5p attenuates HIBD and supplies a novel perspective for HIBD management.
other	35380163	hsa-mir-223	Granulomatosis with Polyangiitis	A distinction between GPA and healthy controls was the best for miR3p, whereas miR-664a-3p discriminated between active vs.
other	35380163	hsa-mir-664a	Granulomatosis with Polyangiitis	A distinction between GPA and healthy controls was the best for miR3p, whereas miR-664a-3p discriminated between active vs.
genetics_GWAS	35379867	hsa-mir-27a	Bipolar Disorder	Our study highlights the importance of miR-27a and its polymorphism at rs895819 in bipolar disorder.
other	35379844	hsa-mir-1	Pulmonary Disease, Chronic Obstructive	Additionally, in patients with COPD, we identified miR3p as a miRNA induced by smoking.
other	35379829	hsa-mir-125b	Coronary Artery Disease	Interestingly, miRNAs as miR-125b playing a role in vascular calcification were differentially expressed in the classical subset in patients suffering from CAD and not MI in comparison to control samples.
target gene	35379785	hsa-mir-4731	Breast Neoplasms	Tumor suppressive role of microRNA-4731-5p in breast cancer through reduction of PAICS-induced FAK phosphorylation.
other	35379653	hsa-mir-6125	Hepatitis, Autoimmune	Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity.
other	35379653	hsa-mir-4634	Hepatitis, Autoimmune	Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity.
other	35379653	hsa-mir-196	Hepatitis, Autoimmune	Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity.
lncRNA target	35379225	hsa-mir-218	Ventricular Premature Complexes	5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1.
other	35379225	hsa-mir-218	Endometriosis	METHODS: Herein, qPCR was performed to analyze the expression levels of LASP1 and miR5p between endometriosis (Ems) cells and control cells.
other	35379158	hsa-mir-24-1	Carcinoma, Hepatocellular	1-5p was a novel biomarker for HCC diagnosis identified in this study.
genetics_knock down_suppress	35379058	hsa-mir-653	Adenocarcinoma of Lung	Furthermore, miR-653 silence or HK2 addition neutralized the effects of circ_0061140 knockdown on LUAD progression under hypoxia. This study elaborated that circ_0061140 accelerated hypoxia-triggered glycolysis, migration and invasion in LUAD cells via downregulating miR-653 and increasing HK2 expression.
transcription factor target	35379056	hsa-mir-222	Medulloblastoma	3p suppressed cell viability, altered cell cycle distribution, and inhibited the formation of MB stem-like cells via the Notch2/c-myc pathway.
other	35378915	hsa-mir-105-2	Adenocarcinoma of Lung	2 were closely related to the TME and affected the prognosis of LUAD by altering the abundance of TICs.
other	35378915	hsa-mir-873	Adenocarcinoma of Lung	2 were closely related to the TME and affected the prognosis of LUAD by altering the abundance of TICs.
other	35378789	hsa-mir-363	Endometriosis	In our research, we aim to investigate the role of miR-363 in the pathogenesis of endometriosis.
genetics_knock down_promote	35378711	hsa-mir-1305	Uterine Cervical Neoplasms	Knockdown of circ_0005576 suppressed the proliferation, migration, and invasion of CC cells, while the silence of miR-1305 facilitated the development of CC cells.
genetics_overexpression_promote	35378649	hsa-mir-338	Uterine Cervical Neoplasms	Overexpression of DSCAM-AS1 promoted cervical carcinoma cell growth and cycle via regulating miR
genetics_overexpression_promote	35378445	hsa-mir-600	Colorectal Neoplasms	Overexpression of MIR600HG affected the expression of downstream molecules, such as miR
transcription factor target	35378380	hsa-mir-142	Inflammation	Taken together, our results suggest that miR3p and miR-451 released in EVs by activated neutrophils can target EC to trigger an inflammatory cascade and induce direct vascular damage, and that therapeutic strategies based on the inhibition of these miRNAs in ECs will have implications for neutrophil-mediated inflammatory diseases.
other	35378380	hsa-mir-223	Inflammation	Importantly, miR-223, miR3p and miR-451 are markedly increased in kidney biopsies from patients with active ANCA-associated vasculitis, a severe autoimmune disease that is prototypical of a neutrophil-induced microvascular damage.
transcription factor target	35378380	hsa-mir-451	Inflammation	Taken together, our results suggest that miR3p and miR-451 released in EVs by activated neutrophils can target EC to trigger an inflammatory cascade and induce direct vascular damage, and that therapeutic strategies based on the inhibition of these miRNAs in ECs will have implications for neutrophil-mediated inflammatory diseases.
other	35378300	hsa-mir-495	Osteoarthritis	Collectively, these findings revealed a protective effect of circVMA21in OA by intercepting the miR3p/FBWX7 crosstalk.
epigenetics	35378241	hsa-mir-182	Inflammatory Bowel Diseases	5p aggravates UC by inactivating the Wnt/beta-catenin signaling pathway through DNMT3A-mediated SMARCA5 methylation.
other	35378210	hsa-mir-142	Gout	In addition, the results suggested that the lncRNA-NEAT1-miR3p-IL-6 pathway may be a potential RNA regulatory pathway that controls the progression of gout disease.
other	35378083	hsa-mir-34a	Chemical and Drug Induced Liver Injury	These results indicated that imbalance in macrophages M1/M2 polarization mediated by activation of Notch signaling due to reduced miR-34a-5p level may contribute to additive effects on disorder of inflammatory factors secretion and subsequent liver injury following long-term DBP and BaP co-exposure.
genetics_overexpression_promote	35377982	hsa-mir-34a	Triple Negative Breast Neoplasms	Overexpression of WTAPP1 and EEF2K increased proliferation, invasion and migration of TNBC cells, while overexpression of miR-34a showed different results.
genetics_overexpression_promote	35377981	hsa-mir-203	Osteosarcoma	FAM230B overexpression in OS cells increased premature miR-203 level and decreased mature miR-203 level.
exosome	35377980	hsa-mir-92a	Liver Neoplasms	Tumor fibroblast-derived exosome marker proteins and miR-92a-3p have good diagnostic value in liver cancer, indicating that they may be new diagnostic markers for liver cancer.
lncRNA target	35377979	hsa-mir-93	Carcinoma, Hepatocellular	5p on HCC cell growth may be carried out by inhibiting the PCK1 expression, suggesting that miR
other	35377267	hsa-mir-375	Diabetes Mellitus	MicroRNA-375 (miR-375) is upregulated in the islets of some diabetics and is correlated with poor outcome.
lncRNA target	35377130	hsa-mir-559	Atherosclerosis	With high level of ASLNC18810 in ECs, ASLNC18810 binds to miR-559 as a miRNA sponge and suppresses the inhibition effect of miR-559 on Bax protein, this direct positive transcriptional regulation between HIF-1alpha and Bax endows the apoptotic property in ECs induced by Ox-LDL.
lncRNA target	35373434	hsa-mir-185	Diabetic Retinopathy	Collectively, our findings reveal a novel lncRNA FAF/miR5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI.
lncRNA target	35373434	hsa-mir-185	Syphilis	Collectively, our findings reveal a novel lncRNA FAF/miR5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI.
circRNA target	35373391	hsa-mir-873	Thyroid Cancer, Papillary	CONCLUSION: Circ_0058129 expedited PTC progression through the miR
lncRNA target	35373390	hsa-mir-421	Colorectal Neoplasms	CONCLUSION: Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR
lncRNA target	35373390	hsa-mir-195	Colorectal Neoplasms	CONCLUSION: Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR
circRNA target	35372340	hsa-mir-451a	Thyroid Cancer, Papillary	We further found that miR-451a inhibited PTC cell proliferation, migration, and invasion by regulating S1PR2.
lncRNA target	35372039	hsa-mir-552	Breast Neoplasms	SLC16A1-AS1 inhibits BC carcinogenesis and progression via the SLC16A1-AS1/miR
circulation_biomarker_diagnosis_down	35371977	hsa-mir-181a	Glioblastoma	Furthermore, miR-181a-5p was detected in GBM cell-derived extracellular vesicles (EVs) as well as patient serum-derived EVs.
lncRNA target	35371970	hsa-mir-138	Mouth Neoplasms	MiR-138 mimics and inhibitors were used to functionally investigate the role of miR-138 on CAF phenotype and the resulting change in their ability to support OSCC invasion.
lncRNA target	35371970	hsa-mir-138	Squamous Cell Carcinoma of Head and Neck	This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its effects on their phenotype and invasion of adjacent OSCC cells.
transcription factor target	35371347	hsa-mir-130b	Hydrocephalus	Moreover, upregulated hsa-miR-130b-3p might mediate the downregulation of the phosphatase and tensin homolog gene (PTEN), which has been associated with hydrocephalus, via binding to its 3'-untranslated region by dual-luciferase reporter assay.
circulation_biomarker_prognosis_up	35371343	hsa-mir-200a	Carcinoma, Ovarian Epithelial	ROC analysis showed that the expression of serum miR-200a/b can distinguish EOC patients from the control group.
circulation_biomarker_prognosis_up	35371343	hsa-mir-200b	Carcinoma, Ovarian Epithelial	ROC analysis showed that the expression of serum miR-200a/b can distinguish EOC patients from the control group.
lncRNA target	35371339	hsa-mir-221	Squamous Cell Carcinoma of Head and Neck	In conclusion, for the first time, we demonstrated lncRNA LEF1-AS1 as a novel biomarker for HNSCC and suggested LEF1-AS1/miR5p/GJA1 axis as promising diagnostic and therapeutic target for HSCC treatment.
lncRNA target	35371326	hsa-mir-184	Carcinoma, Renal Cell	5p regulated A-498 and 786-O cell proliferation, invasion and apoptosis by directly targeting NUS1.
genetics_knock down_promote	35371319	hsa-mir-421	Adenocarcinoma of Lung	Gain- and loss-of-function assays showed that miR-421 promoted LUAD cell migration and invasion.
transcription factor target	35371310	hsa-mir-145	Glioma	Taken together, these results suggest that miR5p could be a novel therapeutic target for gliomas through the suppression of TCTP in GSCs.
circulation_biomarker_prognosis_down	35371309	hsa-mir-34a	Carcinoma, Hepatocellular	Conclusions: Collectively, serum exosomal miR-34a is significantly down-regulated in HCC patients and might be a novel noninvasive biomarker for diagnosis and prognosis of HCC.
lncRNA target	35371308	hsa-mir-130b	Glioblastoma	Conclusions: CircASPM can promote GBM progression via regulating miR-130b-3p/E2F1 axis, suggesting that circAPSM could provide an effective biomarker for GBM diagnosis and prognostic evaluation and possibly being used for molecular targeted therapy.
target gene	35371298	hsa-let-7b	Ovarian Neoplasms	Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b.
other	35370692	hsa-mir-802	Diabetic Nephropathies	Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys.
other	35370692	hsa-mir-132	Diabetic Nephropathies	Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys.
other	35370692	hsa-mir-101a	Diabetic Nephropathies	Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys.
other	35370692	hsa-mir-379	Diabetic Nephropathies	Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys.
other	35370692	hsa-mir-34a	Diabetic Nephropathies	Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys.
epigenetics	35370461	hsa-mir-571	Hypertension	Conclusions: Our study suggested that hydroxymethylation in the promoter regions controlled the level of miR-3571 and revealed the important roles of miR-3571 and CLDN1 in VSMCs during the development of hypertension.
lncRNA target	35370458	hsa-mir-204	Esophageal Squamous Cell Carcinoma	5p inhibited cell proliferation and induced cell apoptosis in ESCC through targeting Nestin, which might provide novel therapeutic targets for ESCC therapy.
other	35369902	hsa-mir-31	Multiple Myeloma	CONCLUSION: Our findings highlight a novel mechanism, in which circPSAP functions as a miR3p sponge to impact MM cell proliferation, apoptosis and BTZ sensitivity by regulating HDAC4 expression.
lncRNA target	35369850	hsa-mir-145	Hypertension, Pulmonary	5p/Akt3 was supposed to perform as a prospective molecular target for the treatment of PH.
other	35369634	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: Detection of miRNA-125b expression level is complementary to MRI diagnosis of head and neck SCC.
circulation_biomarker_diagnosis_ns	35368948	hsa-mir-92a	Urinary Bladder Neoplasms	OBJECTIVE: To study the clinical value of Xiaozheng decoction combined with bladder perfusion treating bladder cancer after the operation and its effect on serum miR-143 and miR-92a.
circulation_biomarker_diagnosis_ns	35368948	hsa-mir-143	Urinary Bladder Neoplasms	OBJECTIVE: To study the clinical value of Xiaozheng decoction combined with bladder perfusion treating bladder cancer after the operation and its effect on serum miR-143 and miR-92a.
lncRNA target	35368896	hsa-mir-454	Carcinoma, Renal Cell	CONCLUSION: ZONs treatment notably impeded proliferation, lipid accumulation, and oxidation in RCC cells, through upregulating miR
other	35368799	hsa-mir-182	Colorectal Neoplasms	Increased levels of miR-223 and miR-182 were associated with increased risk of disease progression, and the more accurate the value of miR-223 and miR-182, the earlier the diagnosis of colorectal cancer.
other	35368799	hsa-mir-223	Colorectal Neoplasms	Increased levels of miR-223 and miR-182 were associated with increased risk of disease progression, and the more accurate the value of miR-223 and miR-182, the earlier the diagnosis of colorectal cancer.
lncRNA target	35368795	hsa-mir-708	Osteoporosis	Therefore, we hypothesized that TMC3-AS1 could inhibit osteoblast apoptosis and interact with miR-708, a regulator of osteoblast apoptosis in OS.
other	35368701	hsa-mir-20b	Arthritis, Rheumatoid	The networks containing tissue-specific expressed hub genes are as follows: ARAP1-AS2/miR-20b-3p/TRIM3, ARAP1-AS2/miR-30c-3p/FRZB.
lncRNA target	35368699	hsa-mir-145	Prostatic Neoplasms	5p can inhibit NED and tumor growth by targeting SOX11, which regulates the expression of MYCN, and that this could be a novel therapeutic strategy for preventing the progression of PCa.
circulation_biomarker_diagnosis_up	35368523	hsa-mir-1	Diabetic Neuropathies	3p was downregulated (Fold change = 0.9, P = 0.028) in whole blood samples from DN patients compared to the control group.
lncRNA target	35367965	hsa-mir-34b	Mental Disorders	RESULTS: miRNA array data and correlation analysis showed that miR-34b was the most relevant miRNA among Pb neurotoxicity and neuropsychiatric disorders, and synapse-associated membrane protein 2 (VAMP2) was the target gene regulating synapse function. CONCLUSION: Early-life Pb exposure might exert synapse-toxic effects via inhibiting VAMP2 mediated by upregulation of miR-34b and shed a light on the underlying relationship between Pb neurotoxicity and developmental neuropsychiatric disorders.
lncRNA target	35367965	hsa-mir-34b	Neurodevelopmental Disorders	CONCLUSION: Early-life Pb exposure might exert synapse-toxic effects via inhibiting VAMP2 mediated by upregulation of miR-34b and shed a light on the underlying relationship between Pb neurotoxicity and developmental neuropsychiatric disorders.
lncRNA target	35367362	hsa-mir-27a	Carcinoma, Non-Small-Cell Lung	MALAT1 facilitated tumor growth in vivo via targeting miR-27a-5p/PBOV1 and enhanced resistance of NSCLC cells to GEM.
genetics_knock down_promote	35367291	hsa-mir-34a	Hearing Loss, Age-Related	Our previous studies revealed that miR-34a suppresses autophagy in the ageing cochlea, which correlates with cochlear hair cell loss and age-related hearing loss (AHL). These findings open new avenues for protection against AHL through miR-34a/ATG9a/TFEB modulation of autophagy.
other	35366907	hsa-mir-125a	Adenocarcinoma of Lung	Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients.
other	35366907	hsa-mir-500a	Adenocarcinoma of Lung	Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients.
other	35366907	hsa-mir-99a	Adenocarcinoma of Lung	Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients.
other	35366766	hsa-mir-3	Diabetic Nephropathies	It is suggested that miR-33 and ABCA1 genes evaluation could be a new therapeutic strategy for nephropathy diabetes remediation.
other	35366759	hsa-mir-149	Genital Diseases, Male	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-1246	Genital Diseases, Male	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-149	Asthenozoospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-149	Oligospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-638	Oligospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-1246	Oligospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-638	Asthenozoospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-1246	Asthenozoospermia	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
other	35366759	hsa-mir-638	Genital Diseases, Male	Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia.
transcription factor target	35366755	hsa-mir-214	Acute Kidney Injury	According to these findings, inhibiting miR3p would alleviate TEC ferroptosis in cis-AKI via GPX4.
circulation_biomarker_diagnosis_down	35366691	hsa-mir-17	Endometriosis	This study investigated the diagnostic value of serum miR
circulation_biomarker_diagnosis_down	35366691	hsa-mir-424	Endometriosis	This study investigated the diagnostic value of serum miR
circulation_biomarker_diagnosis_ns	35366615	hsa-mir-518	Diabetes, Gestational	CONCLUSION: High expression of miR-518 assists the diagnosis of GDM and GDM&HDCP, and miR-518 regulates the serum inflammatory factors by inhibiting PPARalpha.
genetics_knock down_promote	35366388	hsa-mir-223	Carcinoma, Hepatocellular	Both knockdown of miR-223 and overexpression of ECT2 and FAT1 reversed FGD5-AS1 silencing-mediated suppression of HCC cell proliferation and stemness.
genetics_overexpression_promote	35366327	hsa-mir-215	Breast Neoplasms	5p or overexpression of SREBP1 promoted the tumorigenic behaviors of BC cells by stimulating lipid metabolism and counteracted the antitumor effect of Al-MPS.
other	35365601	hsa-mir-592	Neurodevelopmental Disorders	The findings demonstrate that miR-592 might play a novel role in treating the neurodevelopmental-associated disorder.
exosome	35365456	hsa-let-7d	Down Syndrome	CONCLUSION: Let-7d-5p in amniotic fluid exosomes may promote oxidative stress events in the brain of fetuses with DS by regulating BACH1 expression.
lncRNA target	35365349	hsa-mir-135b	Osteolysis	Taken together, our findings suggest that LINC01534/miR-135b-5p/PTPRT axis might be a valuable therapeutic target for the treatment of debris-induced osteolysis.
lncRNA target	35365168	hsa-mir-362	Mouth Neoplasms	5p and miR-500b-5p and recruiting CEBPB, thereby promoting OSCC progression via NFkappaB signaling pathway.
other	35365098	hsa-mir-205	Urinary Bladder Neoplasms	3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually.
other	35365098	hsa-mir-210	Urinary Bladder Neoplasms	3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually.
other	35365098	hsa-mir-34a	Urinary Bladder Neoplasms	3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually.
genetics_overexpression_suppress	35364459	hsa-mir-205	Angelman Syndrome	5p in the progression of human aortic vascular smooth muscle cells (HAVSMCs) METHODS: Use ox-LDL to induce HAVSMCs to construct an in vitro cell model of AS, and silence/overexpress miR
lncRNA target	35364458	hsa-mir-106b	Adenocarcinoma of Lung	In conclusion, HNRNPA2B1 inhibits SFRP2 and activates Wnt-beta/catenin via m6A-mediated maturing of miR-106b-5p to aggravate stemness and LUAD progression, which potentially offered HNRNPA2B1 as a potential marker in CSCs-targeted treatment for LUAD.
lncRNA target	35364057	hsa-mir-940	Esophageal Squamous Cell Carcinoma	CONCLUSION: Our findings suggested that GATA2-AS1, expressed at low levels in ESCC, plays a crucial role in the progression of ESCC by targeting the miR-940/PTPN12 axis and could be a potential drug target to treat ESCC patients.
transcription factor target	35363937	hsa-mir-126	Colorectal Neoplasms	Previously, we showed that miR-126 functions as a tumour suppressor in CRC and is inversely correlated with tumour proliferation, metastasis and patient prognosis.
genetics_overexpression_promote	35363355	hsa-mir-490	Colonic Neoplasms	In addition, overexpression of miR
other	35363256	hsa-mir-374a	Inflammatory Bowel Diseases	Our findings suggest that miR-374a-5p reduction is a central driver of inflammation in IBD, and its therapeutic supplementation could reduce monocyte-driven inflammation in IBD or other immune-mediated diseases.
genetics_overexpression_promote	35363093	hsa-mir-625	Carcinoma, Non-Small-Cell Lung	Furthermore, LRRC8E overexpression abolished the promotive effect of miR-625 abundance on the DDP sensitivity in DDP-resistant NSCLC cells.
lncRNA target	35363088	hsa-mir-143	Retinal Neovascularization	Intravitreal injection of synthetic miR-143 mimics significantly ameliorate retinal neovascularization in OIR rats. These findings suggest that miR-143 appears to be essential for limiting endothelial cell-matrix adhesion, thus suppressing retinal neovascularization.
other	35363088	hsa-mir-143	osteogenesis imperfecta type 1	Intravitreal injection of synthetic miR-143 mimics significantly ameliorate retinal neovascularization in OIR rats.
other	35363088	hsa-mir-143	Retinal Diseases	In this study, we show that miR3p is significantly downregulated in the retina of a rat model of oxygen-induced retinopathy (OIR) by miRNA-sequencing.
lncRNA target	35362879	hsa-mir-186	Urinary Bladder Neoplasms	Our study identified that circ3323 modulates metastasis of BCa through miR5p/APP axis and may serve as a promising prognostic biomarker for BCa, which provides novel insights into treatment of BCa.
genetics_overexpression_promote	35362548	hsa-mir-129	Colorectal Neoplasms	5p overexpression reduced TRIP13 expression.
other	35362387	hsa-mir-668	Diabetes Mellitus, Type 2	Our findings showed that Tincr sponged miR3p, which attenuated abnormal IESC differentiation in DM by regulating Klf3 expression.
lncRNA target	35362116	hsa-mir-451	Osteoarthritis	The goals of this study were to evaluate crosstalk between these signaling pathways and determine if miR-122 and miR-451 exert their protective/destructive effects through these pathways in an in vitro model of OA.
lncRNA target	35362116	hsa-mir-122	Osteoarthritis	The goals of this study were to evaluate crosstalk between these signaling pathways and determine if miR-122 and miR-451 exert their protective/destructive effects through these pathways in an in vitro model of OA.
other	35361385	hsa-mir-202	Pre-Eclampsia	MATERIALS AND METHODS: Quantitative real-time PCR was utilized to determine the expression of NORAD, microRNA (miR)5p, and fragile X-related gene 1 (FXR1) in PE and normal placenta tissues.
genetics_overexpression_promote	35361384	hsa-mir-599	Uterine Cervical Neoplasms	Functionally, overexpression of miR-599 suppressed cell proliferation, migration, and invasion of cervical cancer cells, while downregulation of miR-599 had opposite effects.
other	35360844	hsa-mir-152	Craniosynostoses	Moreover, the luciferase reporter assay revealed that the regulatory axis and HOTAIR-miRCAMKIIalpha were the regulatory mechanisms of HOTAIR in the osteoclast function and development of craniosynostosis.In this study, our data showed that HOTAIR could promote osteoclast differentiation by binding miR-152.
other	35360454	hsa-mir-206	Muscular Injury	Experimental results indicated that injury caused by radiation persisted despite gradual healing of the TVP muscle and miR-206 regulatory pathway plays a key role in regulating radiation-induced muscle injury.
other	35360081	hsa-mir-1247	Osteoporosis, Postmenopausal	5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP.
other	35360081	hsa-mir-766	Osteoporosis, Postmenopausal	5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP.
other	35360081	hsa-mir-24	Osteoporosis, Postmenopausal	5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP.
other	35360081	hsa-mir-124	Osteoporosis, Postmenopausal	5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP.
other	35360081	hsa-mir-30	Osteoporosis, Postmenopausal	5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP.
circulation_biomarker_diagnosis_down	35359635	hsa-mir-126	Multiple Sclerosis	Serum miR
other	35359454	hsa-mir-210	psoriasis 1	Importantly, IFNgamma-sEVs significantly improved the delivery efficiency and stability of ASO-210, the antisense oligonucleotides of miR-210 block the immune imbalance and subsequent psoriasis development.
transcription factor target	35359405	hsa-mir-223	Lymphoma, Large B-Cell, Diffuse	Our study uncovers a negative functional loop consisting of a Fbw7-mediated LDHA/lactate/miR-223 axis, which may support the future ABC-DLBCL therapy by targeting LDHA-related inhibition.
lncRNA target	35359381	hsa-mir-370	Glioma	CONCLUSIONS: Silencing of CHRM3-AS2 expression inhibited the malignant progression of glioma by regulating miR
genetics_knock down_promote	35359342	hsa-mir-138	Carcinoma, Hepatocellular	5p inhibition partially suppressed the effects of circ-TLK1 knockdown on the malignant behaviors of HCC cells.
circulation_biomarker_diagnosis_ns	35359267	hsa-mir-92a	Colorectal Neoplasms	A Prussian blue nanoparticles-based fluorescent nanoprobe for monitoring Since microRNA-92a (miR-92a) and microRNA-21 (miR-21) are crucial biomarkers for colorectal cancer (CRC), monitoring miR-92a and miR-21 in serum is very significant for the early diagnosis of CRC.
circulation_biomarker_diagnosis_ns	35359267	hsa-mir-21	Colorectal Neoplasms	A Prussian blue nanoparticles-based fluorescent nanoprobe for monitoring Since microRNA-92a (miR-92a) and microRNA-21 (miR-21) are crucial biomarkers for colorectal cancer (CRC), monitoring miR-92a and miR-21 in serum is very significant for the early diagnosis of CRC.
lncRNA target	35359242	hsa-mir-671	Parkinson Disease	5p to inhibit NF-kappaB in IS models, which provided a theoretical foundation for the protective effect of downregulating ANRIL for IS patients.
lncRNA target	35359242	hsa-mir-671	Ischemic Stroke	5p to inhibit NF-kappaB in IS models, which provided a theoretical foundation for the protective effect of downregulating ANRIL for IS patients.
other	35358781	hsa-mir-197	Neuroblastoma	5p-E2F1 axis in neuroblastoma metastasis and growth.
lncRNA target	35358777	hsa-mir-205	Liver Diseases, Alcoholic	mediated importinalpha5 inhibition via the NF-kappaB signaling pathway, highlighting a promising therapeutic target for ALD treatment with the help of traditional Chinese medicine.
lncRNA target	35358766	hsa-mir-20a	Stomatognathic Diseases	CONCLUSION: MiR-20a up-regulation accelerated the viability, migration and osteogenic/odontoblastic differentiation potential of DPSCs by regulating NF-kappaB/p65 signaling pathway via targeting IL-8, which might be a potential treatment target for dental diseases.
other	35358709	hsa-mir-130a	Arthritis, Rheumatoid	MiR-130a-3p is a disease-related miRNA and Kruppel-like factor 9 (KLF9) is a zinc finger transcription factor, which are involved in RA pathogenesis.
lncRNA target	35358540	hsa-mir-128	Gastrointestinal Stromal Tumors	In summary, SNHG16 up-regulated by CTCF facilitated the progression of GIST through miR
other	35358479	hsa-mir-96	Colorectal Neoplasms	Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment.
other	35358479	hsa-mir-182	Colorectal Neoplasms	Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment.
other	35358479	hsa-mir-183	Colorectal Neoplasms	Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment.
genetics_GWAS	35358276	hsa-mir-499	Autoimmune Diseases	Association between miRNA-499 gene polymorphism and autoimmune diseases: A INTRODUCTION: The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. CONCLUSIONS: Our meta-analysis suggested that the miRNA-499 rs3746444 polymorphism was associated with an elevated risk of autoimmune diseases in the overall analysis as well as Caucasian and Asian populations.
lncRNA target	35358000	hsa-mir-584	Urinary Bladder Neoplasms	CircLONP2 depletion inhibited cell viability, proliferation, and invasion of BC cell lines, which could be partially rescued by miR
other	35357625	hsa-mir-150	Myocardial Infarction	METHODS AND RESULTS: A myocardial ischemia (MI) injury rat model was constructed to detect miR5p and tetratricopeptide repeat domain 5 (TTC5) expression during heart ischemia injury.
other	35357625	hsa-mir-150	Myocardial Ischemia	METHODS AND RESULTS: A myocardial ischemia (MI) injury rat model was constructed to detect miR5p and tetratricopeptide repeat domain 5 (TTC5) expression during heart ischemia injury.
lncRNA target	35357586	hsa-mir-548c	Colorectal Neoplasms	Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. CONCLUSION: Overall, these findings suggested that LINC01088 directly targeted miR-548b-5p and miR-548c-5p, promoting G3BP1 and PD-L1 expression, which facilitated colorectal cancer progression and immune escape.
lncRNA target	35357586	hsa-mir-548b	Colorectal Neoplasms	Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. CONCLUSION: Overall, these findings suggested that LINC01088 directly targeted miR-548b-5p and miR-548c-5p, promoting G3BP1 and PD-L1 expression, which facilitated colorectal cancer progression and immune escape.
lncRNA target	35357550	hsa-mir-214	Carcinoma, Hepatocellular	ALKBH5-induced NEAT1 promoted cell proliferation and migration of HCC by sponging miR-214 in vitro, which may provide a potential therapeutic target for HCC.
genetics_knock down_promote	35357059	hsa-mir-217	Carcinoma, Renal Cell	The inhibitory effects of circ_0008717 knockdown on RCC cell malignant behaviors were reversed by miR-217 inhibition or FBXO17 overexpression. CONCLUSIONS: Circ_0008717 aggravated the progression of RCC by activating FBXO17 through targeting miR-217, which provided a novel mechanism for circ_0008717 to participate in RCC progression.
transcription factor target	35356885	hsa-mir-100	Femur Head Necrosis	5p may be involved in the pathogenesis of NONFH by inhibiting the migration and osteogenic differentiation of rBMSCs.
circRNA target	35356749	hsa-mir-370	Colorectal Neoplasms	CONCLUSION: In summary, our data highlight circRNA_101277 as a novel driver of CRC cell cisplatin resistance that functions by sequestering miR-370 and thereby enhancing IL-6 expression. These findings suggest that this circRNA_101277/miR-370/IL-6 axis may represent a critical axis of chemoresistance in CRC that can be targeted to diagnose and/or treat this cancer.
transcription factor target	35356421	hsa-mir-532	Carotid Artery Diseases	Therefore, FBLN5 may play an important role in carotid atherosclerosis via hsa-mir-128 and hsa-mir3p as well as become an essential target for treatment.
transcription factor target	35356421	hsa-mir-128	Carotid Artery Diseases	Therefore, FBLN5 may play an important role in carotid atherosclerosis via hsa-mir-128 and hsa-mir3p as well as become an essential target for treatment.
target gene	35356209	hsa-mir-216b	Leukemia, Myeloid, Acute	Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun.
exosome	35356153	hsa-mir-200a	Colorectal Neoplasms	sEV-derived miR
exosome	35356153	hsa-mir-21	Colorectal Neoplasms	sEV-derived miR
lncRNA target	35355424	hsa-mir-223	Breast Neoplasms	3p to regulate FABP7, thereby promoting proliferation, migration, invasion, and EMT of BC cells, and inhibiting cell apoptosis.
transcription factor target	35355364	hsa-mir-155	Pneumonia	BMSCs may protect lung tissues from MV-induced injury, inhibit lung inflammation, promote autophagy through upregulating of miR5p.
genetics_knock down_suppress	35355231	hsa-mir-1179	Uterine Cervical Neoplasms	In addition, circ_0000263 knockdown reduced CC tumor growth by miR-1179/ABL2 axis.
circulation_biomarker_diagnosis_down	35354913	hsa-mir-204	Arthritis, Rheumatoid	Furthermore, Spearman correlation analysis indicated that plasma exosomal miR
other	35354890	hsa-mir-423	Myocardial Infarction, Acute	3p.
other	35354890	hsa-mir-146a	Myocardial Infarction, Acute	3p.
target gene	35354791	hsa-mir-411	Stomach Neoplasms	Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis.
other	35354691	hsa-mir-181a	Carcinoma, Non-Small-Cell Lung	Two types of NSCLC cell lines, A549 and H69, and their CDDP-resistant cell lines, A549R and H68R, were used to investigate PD-L1 expression and microRNA mir-181a expression. Increased PD-L1 expression in acquired cisplatin-resistant lung cancer cells is dependent on mir-181a in NSCLC.
lncRNA target	35354145	hsa-mir-1913	Stomach Neoplasms	In addition, miR-1913 targeted SETD1A, which was highly expressed in GC cells.
transcription factor target	35353669	hsa-mir-196b	Glioma	The miR-196b-5p altered the migration, proliferation, invasion, and apoptosis of glioma cells by regulating target genes, according to in vitro experiments.Conclusions: A miRNA-based individualized prognostic prediction model was constructed for glioma and miR-196b-5p was identified as a potential biomarker of glioma development.
genetics_overexpression_suppress	35353623	hsa-mir-32	Neuralgia	5p agomir or overexpression of miR
genetics_overexpression_suppress	35353623	hsa-mir-32	Trigeminal Neuralgia	5p agomir or overexpression of miR
genetics_overexpression_promote	35353623	hsa-mir-32	Hyperalgesia	Conversely, miR5p overexpression in injured TG suppressed the increased expression of Cav3.2 and reversed mechanical allodynia.
epigenetics	35353623	hsa-mir-32	Cranial Nerve Injuries	Nerve injury increased the methylated histone occupancy of binding sites for the transcription factor glucocorticoid receptor in the miR5p promoter region.
lncRNA target	35353555	hsa-mir-29b	Osteoarthritis	An aging-related miRNA, miR-29b-5p, was first found to be markedly down-regulated in OA cartilage, and their up-regulation suppressed the expression of matrix metalloproteinases and senescence-associated genes (P16(INK4a)/P21) via ten-eleven-translocation enzyme 1 (TET1).
circulation_biomarker_diagnosis_ns	35353360	hsa-mir-128	Asthma	Our results revealed the serum of circ 001372 against inflammation in ovalbumin-induced asthma through Sirt1/NFAT5 by miRNA3p.
circulation_biomarker_diagnosis_ns	35353339	hsa-mir-183	Carotid Artery Diseases	In serum samples from individuals with carotid atherosclerosis, Higher levels of miR
circRNA target	35353073	hsa-mir-149	Glomerulonephritis, Membranous	Our results confirmed that circ_CDYL specifically targeted miR
lncRNA target	35353027	hsa-mir-631	Carcinoma, Non-Small-Cell Lung	In brief, BMSC-Exo mediated E2F2 via delivering miR-631 to NSCLC cells to modulate the malignant behavior of NSCLC.
other	35352891	hsa-mir-494	Brain Ischemia	CONCLUSION: MiR3p exacerbates brain injury and neuronal injury by regulating Bhlhe40 after I/R.
genetics_knock down_suppress	35352818	hsa-mir-200a	Hepatitis B	CONCLUSION: CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis.
genetics_knock down_suppress	35352818	hsa-mir-200a	Carcinoma, Hepatocellular	CONCLUSION: CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis.
lncRNA target	35352617	hsa-mir-495	Lymphoma, Large B-Cell, Diffuse	However, inhibiting miR
lncRNA target	35352613	hsa-mir-502	Osteoarthritis	CONCLUSION: Circ-PRKCH contributed to IL-1beta-treated cell phenotypic changes in chondrocytes via modulating miR
genetics_knock down_promote	35352610	hsa-mir-326	Arthritis, Rheumatoid	FZD4 overexpression largely diminished miR-326 accumulation-mediated influences in TNF-alpha-treated RA-FLSs.
circRNA target	35352283	hsa-mir-520h	Medulloblastoma	circSKA3 expression in medulloblastoma tissues was negatively correlated with miR-520 h expression and positively correlated with CDK6 expression. circSKA3 facilitates medulloblastoma progression through miR-520 h/CDK6.
lncRNA target	35352023	hsa-mir-550a	Diffuse Malignant Peritoneal Mesothelioma	Through a gain-of-function approach using miRNA mimics in 3 DMPM cell lines, we demonstrated the tumor-suppressive role of miR-550a-3p.
transcription factor target	35351860	hsa-mir-381	Renal Insufficiency, Chronic	Collectively, our findings proved that BMSC-Exo plays anti-calcification and anti-apoptosis roles in CKD by delivering enclosed miR3p, which directly targets NFAT5 mRNA, and leads to a better understanding of the mechanism of CKD-VC.
other	35351581	hsa-mir-655	Breast Neoplasms	3p axis in breast cancer were successively screened out, consisting of 11 lncRNAs, 17 circRNAs and 12 pseudogene-derived RNAs.
other	35351581	hsa-mir-186	Breast Neoplasms	3p axis in breast cancer were successively screened out, consisting of 11 lncRNAs, 17 circRNAs and 12 pseudogene-derived RNAs.
other	35351580	hsa-mir-10b	Breast Neoplasms	miR-10b-5p downregulation was partially responsible for PIEZO1 upregulation in breast cancer.
genetics_overexpression_promote	35351345	hsa-mir-206	Aortic Dissection	CONCLUSION: SENCR overexpression suppressed VMSC proliferation and migration, maintained the contractile phenotype and suppressed aortic dilatation via the miR-206/myocardin axis.
other	35351157	hsa-mir-223	Asthma	CONCLUSION: We identified a novel mechanism that lTSLP could promote inflammatory cytokines production by miR-223/VHL/HIF-1alpha pathway to upregulate aerobic glycolysis in airway epithelial cells in asthma.
lncRNA target	35351042	hsa-mir-20a	Thyroid Cancer, Papillary	Targeting CALML3-AS1/ miR-20a-5p/RBM38 axis may represent a novel therapeutic strategy in the treatment of PTC.
epigenetics	35350838	hsa-mir-195	Osteosarcoma	The methylation of miR-195 was related to decreased miR-195, it might promote osteosarcoma.
other	35350836	hsa-mir-223	Pars Planitis	3p expression in IUA tissue samples.
genetics_overexpression_promote	35350778	hsa-mir-1972	Arthritis, Rheumatoid	The blockage of miR-1972 significantly abrogated the angiogenesis stimulative ability of RA FLSs derived EVs in ECs, while the overexpression of miR-1972 reversed the effect in ECs. Collectively, RA FLSs derived EVs can promote ECs angiogenesis via miR-1972 targeted p53/mTOR signaling, targeting on RA FLSs derived EVs or miR-1972 provides a promising strategy for the treatment of patients with RA.
lncRNA target	35350667	hsa-mir-338	Carcinoma, Renal Cell	3p, regulated the proliferation, migration and invasion of ccRCC cells via the PI3K/Akt pathway; this finding not only enriches our understanding of the mechanism underlying ccRCC development, but also demonstrates a potential novel therapeutic target for this disease.
target gene	35350655	hsa-mir-519a	Neuroblastoma	Propofol inhibited oxidative stress and inflammation in MPP+-induced neuroblastoma cells by targeting the HOTAIRM1/miR-519a-3p axis
circulation_biomarker_prognosis_up	35350590	hsa-mir-143	Breast Neoplasms	5p in BC tissue of the GSE42072 and serum of the GSE41922 datasets by GEO chip analysis.
lncRNA target	35350588	hsa-mir-20a	Carcinoma, Non-Small-Cell Lung	It is suggested that miR-20a could be used as a biomarker and therapeutic target for the treatment of NSCLC.
lncRNA target	35350563	hsa-let-7c	Carcinoma, Hepatocellular	Then the most potential upstream microRNA contributing to PUDP was identified as let-7c-5p through expression analysis, correlation analysis, and survival analysis.
other	35350177	hsa-mir-139	Ischemia	In conclusion, HA facilitates angiogenesis of MSCs-ECFCs, and this positive effect be associated with activation of the CD44/miR5p pathway, providing a promising strategy for improving severe limb ischemia.
lncRNA target	35349725	hsa-mir-28	Pulmonary Arterial Hypertension	CONCLUSIONS: Silencing of LINC00963 ameliorates PAH via modulating miR
transcription factor target	35349487	hsa-mir-29c	Food Addiction	3p inhibition promoted compulsion-like behavior and also enhanced food addiction vulnerability.
transcription factor target	35349487	hsa-mir-665	Food Addiction	3p inhibition promoted compulsion-like behavior and also enhanced food addiction vulnerability.
genetics_knock down_promote	35349390	hsa-mir-485	Colorectal Neoplasms	Knockdown circPCLE1 refrained CRC proliferation, glucose consumption, lactic acid and pyruvate production, M2 macrophage markers (IL-10, MRC1), N-cadherin, Snail, reduced the proportion of CD206+ and CD168+ macrophages, but expedited M1 macrophage markers (TNF-alpha, IL-6) and E-cadherin, while descending miR
other	35349375	hsa-mir-146a	Intervertebral disc disease	Conclusion: Overall, SLC20A1-1, an IDD regulator, is involved in TNF-alpha-induced NPC apoptosis by sponging miR-146a-5p.
circulation_biomarker_diagnosis_ns	35349355	hsa-mir-7	Atherosclerosis	Consistently, plasma levels of HDAC7-AS1 and MIR5p were found to be significantly associated individuals diagnosed with CHD.
other	35349097	hsa-mir-519a	Fever	We further explored its role in 1-methylphenylpyridinium (MPP(+))-damaged dopaminergic neurons (DAn) and the possible mechanism involving SNHG14, microRNA (miR)-519a-3p, and autophagy-related 10 (ATG10).
genetics_overexpression_suppress	35348974	hsa-mir-195	Breast Neoplasms	miR-195 showed an IDC-specific downregulation, causing overexpression of CCNE1.
circulation_biomarker_diagnosis_ns	35348584	hsa-mir-99	Obesity, Abdominal	Our study suggests that changes in circulating adipose-related miR
circulation_biomarker_diagnosis_ns	35348584	hsa-mir-100	Obesity, Abdominal	Our study suggests that changes in circulating adipose-related miR
lncRNA target	35348441	hsa-mir-27a	Cardiomegaly	Inhibiting miR-27a-3p mitigated cardiac hypertrophy phenotype induced by Ang II.
genetics_overexpression_promote	35348293	hsa-mir-589	Liver Neoplasms	Overexpressed miR
other	35348192	hsa-mir-423	Atrial Fibrillation	In the AF cell model transfected with miR423, the expression of calcium handling proteins, including phosphorylated calmodulindependent protein kinase II, was reduced. The findings highlight the importance of calcium handling protein phosphorylation changes in fibrosisinduced AF and support miR423 detection in human urine as a potential novel approach of AF diagnosis.
lncRNA target	35347965	hsa-mir-34a	Esophageal Neoplasms	MicroRNA-34 a(miR-34 a) expression in esophageal carcinoma tissue is significantly lower than that in normal tissue. This study aims to investigate the inhibitory effect of PAMR on esophageal carcinoma cells, and the relationship between its inhibitory effect on PD-L1 expression and miR-34 a, which is expected to clarify the anti-tumor mechanism of PAMR.
circulation_biomarker_diagnosis_ns	35347894	hsa-mir-16	Adenocarcinoma of Lung	OBJECTIVES: We aimed at investigating whether serum exosomal miR5p could be utilized as an immunotherapy biomarker in lung adenocarcinoma (LUAD) patients administered by programmed cell death ligand-1 (PD-L1) inhibitors, and to evaluate its functions in LUAD progression.
genetics_knock down_promote	35347818	hsa-mir-361	Stomach Neoplasms	3p, and its overexpression reversed the effects of miR
other	35347579	hsa-mir-7	Thyroid Nodule	Differential expression of miRNA in wild-type nodules highlighted that two miRNAs, namely miR5p and miR-548ar-5p, were downregulated in FV-PTCs compared to FAs.
other	35347579	hsa-mir-548ar	Thyroid Nodule	Differential expression of miRNA in wild-type nodules highlighted that two miRNAs, namely miR5p and miR-548ar-5p, were downregulated in FV-PTCs compared to FAs.
circulation_biomarker_diagnosis_ns	35347537	hsa-mir-299	Multiple Sclerosis, Relapsing-Remitting	Moreover, the results showed that there was an increased negative association between Tr1 frequency and plasma-OPN levels in RRMS patients in comparison to HCs and also, we found a moderate positive correlation between plasma-IL-10 and miR
tissue_expression_ns	35347477	hsa-mir-155	nonsyndromic congenital nail disorder 7	In vivo, exposing the developing vasculature to miR-155 promoted hypersprouting, thus phenocopying defects associated with Notch deficiency.
lncRNA target	35347427	hsa-mir-15b	Diabetes Mellitus	CONCLUSION: Kcnq1ot1 regulated beta-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis, which is worthy of further investigation considering its potential in diabetes treatment.
circulation_biomarker_diagnosis_ns	35347106	hsa-mir-613	Osteosarcoma	Besides, serum-EVs could transfer MIAT (EV-MIAT) into osteosarcoma cells, where it is competitively bound to miR-613 to elevate GPR158, thus promoting osteosarcoma cell proliferation and angiogenesis.
lncRNA target	35346892	hsa-mir-744	Cholangiocarcinoma	TM4SF1-AS1 served as tumor promoter of CCA via modulating miR
other	35346790	hsa-mir-106a	Alzheimer Disease	5p).
other	35346790	hsa-mir-204	Alzheimer Disease	5p).
other	35346790	hsa-let-7a	Alzheimer Disease	5p).
other	35346790	hsa-mir-26a	Alzheimer Disease	5p).
other	35346790	hsa-mir-144	Alzheimer Disease	5p).
other	35346790	hsa-mir-101	Alzheimer Disease	5p).
other	35346790	hsa-mir-9	Alzheimer Disease	5p).
other	35346790	hsa-mir-17	Alzheimer Disease	5p).
other	35346790	hsa-mir-26b	Alzheimer Disease	5p).
other	35346790	hsa-mir-1	Alzheimer Disease	5p).
other	35346790	hsa-mir-20a	Alzheimer Disease	5p).
other	35346790	hsa-mir-128	Alzheimer Disease	5p).
other	35346790	hsa-mir-34a	Alzheimer Disease	5p).
other	35346790	hsa-mir-199a	Alzheimer Disease	5p).
other	35346790	hsa-mir-16	Alzheimer Disease	5p).
other	35346790	hsa-mir-335	Alzheimer Disease	5p).
lncRNA target	35346765	hsa-mir-731	Heart Diseases	In addition, mechanistic study demonstrated that Calcineurin/Nfatc3a signaling involved in miR-731 depletion induced abnormal cardiac function and developmental defects. CONCLUSION: MiR-731 regulates cardiac function and morphogenesis through Calcineurin/Nfatc3a signaling.
tissue_expression_ns	35346765	hsa-mir-731	Blind Loop Syndrome	RESULTS: The depletion of miR-731 in zebrafish embryos caused the deficiency of cardiac development and function, which was associated with reduced heart rate, ventricular enlargement and heart looping disorder.
tissue_expression_ns	35346765	hsa-mir-731	Cardiomegaly	The miR-731 morphants show pericardium enlargement, and many DEGs (differentially expressed genes) are enriched in 'Cardiac muscle contraction' and 'Calcium signaling pathway', implying that miR-731 plays a potential role in heart function and development. RESULTS: The depletion of miR-731 in zebrafish embryos caused the deficiency of cardiac development and function, which was associated with reduced heart rate, ventricular enlargement and heart looping disorder.
other	35346765	hsa-mir-731	Developmental Disabilities	In addition, mechanistic study demonstrated that Calcineurin/Nfatc3a signaling involved in miR-731 depletion induced abnormal cardiac function and developmental defects.
exosome	35346324	hsa-mir-21	Esophageal Squamous Cell Carcinoma	CONCLUSION: PABPC1 plays a critical role in ESCC malignant progression by interacting with eIF4G to regulate IFI27 mRNA stability and promote angiogenesis via exosomal miR5p/CXCL10.
circRNA target	35346268	hsa-mir-145	Osteosarcoma	CONCLUSIONS: In conclusion, our study suggested that circ_0001017 may be a novel oncogenic factor during the progression and development of OS by targeting miR
genetics_overexpression_suppress	35346060	hsa-mir-1	Stomach Neoplasms	Overexpressing miR
lncRNA target	35346026	hsa-mir-742	Myocardial Infarction	CONCLUSION: CircRbms1 regulated the miR3p/FOXO1 axis to mediate hypoxia-induced cardiomyocyte injury, suggesting that circRbms1 might be an effective target for MI treatment.
genetics_overexpression_promote	35346026	hsa-mir-742	Cardiomyopathies	3p on hypoxia-induced cardiomyocyte injury was reversed by FOXO1 overexpression.
genetics_overexpression_promote	35345980	hsa-mir-326	Stomach Neoplasms	Through rescue assays, inhibition of GC progression caused by LINC01270 suppression was found to be reversed by the application of miR-326 inhibitor or EFNA3 overexpression.
genetics_overexpression_promote	35345650	hsa-mir-1270	Breast Neoplasms	miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells.
genetics_overexpression_promote	35345511	hsa-mir-506	Carcinoma, Hepatocellular	Furthermore, circSYPL1 overexpression could upregulate EZH2 expression, while miR
other	35345489	hsa-mir-885	Sepsis	5p/HMBOX1 axis in myocardial cell pyroptosis and provide new directions for the treatment of septic myocardial depression.
other	35345380	hsa-mir-27b	Triple Negative Breast Neoplasms	CONCLUSION: The results suggest the possible utilization of miR-27b and miR-451a expression levels as potential predictive risk markers for TNBC patients undergoing TAC chemotherapy.
other	35345380	hsa-mir-451a	Triple Negative Breast Neoplasms	CONCLUSION: The results suggest the possible utilization of miR-27b and miR-451a expression levels as potential predictive risk markers for TNBC patients undergoing TAC chemotherapy.
lncRNA target	35344194	hsa-mir-186	Reperfusion Injury, Cerebral Ischemia	Therefore, these results suggest that FTX might ameliorate CI/RI by regulating the miR5p/MDM4 pathway, providing a new target for stroke impairment treatment.
lncRNA target	35344140	hsa-mir-28	Atherosclerosis	miR-28 inhibitor reversed the effects of FENDRR silencing and reduced atherosclerotic plaque formation. FENDRR competed with TEAD1 to bind to miR-28, thereby reducing HUV-EC-C injury and atherosclerotic plaque formation.
lncRNA target	35343646	hsa-mir-362	Triple Negative Breast Neoplasms	CONCLUSION: CircDHDDS expedited TNBC by swelling DDX5 via adapting miR
target gene	35343645	hsa-mir-1	Autoimmune Diseases	miPEP31 downregulates miR-31 expression, enhances peripheral T(reg) induction, and dramatically suppresses experimental autoimmune encephalomyelitis.
genetics_knock down_promote	35343383	hsa-mir-488	Pancreatic Carcinoma	ERBB2 knockdown in MIA PaCa-2 and PANC-1 cell lines suppressed, but miR-488 inhibition enhanced the cancer cell biological malignant behavior; the effects of miR-488 inhibition on pancreatic cancer cells were significantly reversed by ERBB2 knockdown.
genetics_overexpression_suppress	35343265	hsa-mir-1827	Carcinoma, Ductal, Breast	In summary, our results indicated that overexpression of LINC00092 inhibited the development of IDC through modulating miR-1827/SFRP1 axis, suggesting new therapeutic targets to treat IDC.
transcription factor target	35343021	hsa-mir-130a	Heart Diseases	Recently we indicated that cardiac toxicity of Dox was due to upregulation of miR-130a and further suppressive effect on cardiac Ppargamma in vitro.
transcription factor target	35342753	hsa-mir-206b	Thyroid Cancer, Papillary	CONCLUSION: hsa-miR-206b might be involved in promoting TNM staging in PTC via targeting of LMX1B.
other	35342419	hsa-mir-224	Lung Neoplasms	circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer.
genetics_overexpression_suppress	35342412	hsa-mir-34c	Carcinoma, Renal Cell	The treatment of miR-34c-5p mimic attenuated the cell viability, proliferation, invasion, and migration of RCC cells, in which MMP2 overexpression restored the phenotypes.
other	35342411	hsa-mir-146b	Carcinoma, Renal Cell	Mechanically, LINC01535/miR-146b-5p/TRIM2 axis affected ccRCC progression by mediating the PI3K/Akt signaling. All in all, our observations suggest the LINC01535/miR-146b-5p/TRIM2 axis as a crucial role in ccRCC.
transcription factor target	35342408	hsa-mir-106b	Carcinoma, Hepatocellular	Herein, we found that miR-106b-5p is upregulated in both HCC patients' tumor tissues and HCC cell lines. Altogether, these data suggest that miR-106b-5p promotes cell proliferation and cell cycle and increases HCC cells' resistance to sorafenib through the BTG3/Bcl-xL/p27 signaling pathway.
other	35342404	hsa-mir-194	Gastric Precancerous Lesion	5p/FoxO3a pathway may provide an efficient strategy for the prevention and treatment of GPL.
genetics_overexpression_suppress	35342401	hsa-mir-23a	Squamous Cell Carcinoma of Head and Neck	Overexpression of miR-23a-3p inhibits the growth of oral cancer tumors.
genetics_overexpression_promote	35342398	hsa-mir-4731	Carcinoma, Non-Small-Cell Lung	5p mimic could remarkably restrain cell viability, invasion, and the translational expression level of vimentin and e-cadherin, with promoted cell apoptosis in NSCLC, which were notably reversed by RPLP0 overexpression.
other	35342355	hsa-mir-24	Ovarian Neoplasms	This study first described a miR-23b-3p/miR3p-mediated positive feedback loop between CASC15 and SMAD3, which may reflect the underlying molecular mechanism of CASC15's oncogenic function in ovarian cancer.
other	35342355	hsa-mir-23b	Ovarian Neoplasms	This study first described a miR-23b-3p/miR3p-mediated positive feedback loop between CASC15 and SMAD3, which may reflect the underlying molecular mechanism of CASC15's oncogenic function in ovarian cancer.
transcription factor target	35342350	hsa-mir-200c	Alzheimer Disease	Conclusion and Implications: Our results strongly suggest that dysregulation of miR-200c expression contributes to the pathogenesis of AD, including cognitive impairment through hyperphosphorylated tau.
genetics_knock down_promote	35342341	hsa-mir-1236	Adenocarcinoma of Lung	3p was upregulated and ZEB1 expression reduced after circRAPGEF5 knockdown, and the proliferation, migration, and invasion of LAD cells was inhibited.
transcription factor target	35342340	hsa-mir-122	Liver Neoplasms	In addition, we demonstrated that ILneutralizing strategies limit CSC occurrence and liver tumor progression through miR-122 restored-expression.
exosome	35342334	hsa-mir-197	Nasopharyngeal Carcinoma	Interestingly, exosomal miR
other	35342284	hsa-mir-122	Adenocarcinoma of Lung	CONCLUSIONS: Our data showed that hsa-mir-122 and a number of related genes may affect the prognosis of patients with lung adenocarcinoma by regulating the cytoskeleton, thus promoting tumor angiogenesis and the metastasis of tumor cells.
transcription factor target	35342027	hsa-mir-214	Glioblastoma	However, use of an miR-214 inhibitor reversed the simvastatin suppressive effect on GBM cells.
genetics_overexpression_promote	35341975	hsa-mir-21	Primary Myelofibrosis	Overexpressed PARP-1 reversed the effects of miR-21 on HASM cells, somewhat dependently on PARP
other	35341776	hsa-mir-205	Osteoporosis	QPCR results indicated that KCNQ1OT1 and RICTOR were down-regulated, while miR5p was up-regulated in the osteoporotic patients, as compared with non-osteoporotic controls.
genetics_overexpression_promote	35341446	hsa-mir-132	Stomach Neoplasms	3p overexpression downregulated the protein levels of Wnt1, c-Myc, beta-catenin, proliferating cell nuclear antigen (PCNA) and N-cadherin, and upregulated E-cadherin expression in GC cells, which were all alleviated after KIF21B overexpression.
circRNA target	35341378	hsa-mir-149	Triple Negative Breast Neoplasms	CONCLUSION: Circ_0041732 silencing suppressed TNBC cell tumor properties by decreasing FGF5 expression through miR
other	35341140	hsa-mir-27a	Stomach Neoplasms	pylori-positive patients, the frequency of miR-27a CT genotype at the rs895819 locus and its expression in the gastric cancer group were higher than those in other pathological groups. CONCLUSION: The C allele at miR-27a rs895819 locus may be an oncogene in gastric cancer.
lncRNA target	35340746	hsa-mir-145	Colorectal Neoplasms	5p negatively regulates the proliferation of CRC colo320 cells through downregulating msln gene expression in CRC colo320 cells.
genetics_knock down_promote	35340708	hsa-mir-665	Carcinoma, Non-Small-Cell Lung	In addition, the GPX3 overexpression decreased the promoting effects of miR-665 upregulation on proliferation, migration, and invasion of NSCLC cells.
target gene	35340555	hsa-mir-29c	Osteosarcoma	TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway.
transcription factor target	35340237	hsa-mir-375	Carcinoma, Hepatocellular	In conclusion, this study suggests that miR3p functions as a tumor suppressor which could inhibit the progression of HCC via targeting YWHAZ and CDC42.
other	35340229	hsa-mir-93	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
other	35340229	hsa-mir-34a	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
other	35340229	hsa-mir-154	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
other	35340229	hsa-mir-22	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
other	35340229	hsa-mir-485	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
other	35340229	hsa-mir-9	Osteosarcoma	5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma.
lncRNA target	35340210	hsa-mir-17	Intervertebral Disc Degeneration	Altogether, our findings substantiated that downregulation of GAS5 reduced NPC apoptosis and promoted ECM remodeling, ultimately ameliorating the IVDD via miR
other	35340004	hsa-mir-342	Hypoxia-Ischemia, Brain	3p.
other	35340004	hsa-mir-30	Hypoxia-Ischemia, Brain	3p.
genetics_overexpression_promote	35339891	hsa-mir-499a	Carcinoma, Renal Cell	MiR-499a-5p overexpression suppressed RCC cell growth.
transcription factor target	35339759	hsa-mir-181a	Retinoblastoma	CONCLUSION: miR-181a-5p was significantly downregulated during the development of RB, and it suppressed the malignant behaviors of RB cells by targeting NRAS.
genetics_overexpression_promote	35339367	hsa-let-7i	Granulomatosis with Polyangiitis	Overexpression of let-7i inhibited KGN cell proliferation and decreased oestradiol production in an IMP2-dependent manner, providing a new molecular mechanism for PCOS.
genetics_overexpression_promote	35339367	hsa-let-7i	Polycystic Ovary Syndrome	Overexpression of let-7i inhibited KGN cell proliferation and decreased oestradiol production in an IMP2-dependent manner, providing a new molecular mechanism for PCOS.
other	35339120	hsa-mir-21	Amebiasis	Out of 60 stool samples from amoebic patients, 17 (28.3%) were positive for microRNA-21 of E.
other	35339120	hsa-mir-22	Amebiasis	Out of 60 stool sample from amoebic patients, 27 (45.0%) were positive for microRNA-22 of E.
other	35339026	hsa-mir-24	Pre-Eclampsia	Expression levels of miR3p, was significantly elevated in preeclamptic placentas.
genetics_knock down_suppress	35338913	hsa-mir-1179	Polycystic Ovary Syndrome	Taken together, this study revealed that circ_0043533 knockdown restrained the malignant progression of PCOS via targeting miR-1179.
lncRNA target	35338769	hsa-mir-370	Urinary Bladder Neoplasms	To summarize, our study manifested that LINC01232 accelerates BC progression by targeting miR
transcription factor target	35338412	hsa-mir-326	Triple Negative Breast Neoplasms	miR-326 was downregulated by increased hypoxia/HIF1A and ECM stiffness in chemoresistant tumors, leading to upregulation of ITGA5 and activation of the downstream FAK/Src signaling pathways. In chemoresistant tumors, hypoxia and resulting ECM stiffness repress the expression of the tumor suppressor miRNA, miR-326.
genetics_knock down_promote	35338123	hsa-mir-495	Pre-Eclampsia	In conclusion, miR-495 knockdown can suppress p53/PUMA axis by targeting HDAC2 to enhance biological behaviors of trophoblast cells, which may prevent occurrence of PE.
other	35337919	hsa-mir-15b	Depression	Meanwhile, LBRD also improved the reduced GABA levels in depression by increasing the expression of lncRNA Neat1 and Malat1, as well as decreasing miRNA3p and miRNA-15b-5p.
other	35337919	hsa-mir-144	Depression	Meanwhile, LBRD also improved the reduced GABA levels in depression by increasing the expression of lncRNA Neat1 and Malat1, as well as decreasing miRNA3p and miRNA-15b-5p.
other	35337805	hsa-mir-155	Carcinoma, Ductal, Breast	We aim to study whether miRNA-155 (miR-155), miR-19a and miR-15a can predict inherent RS according to cellular RS in breast cancer (BC) patients. miR-155 and miR-19a discriminate between BC patients with and without cellular RS with area under the ROC curve 0.98 and 0.68.
other	35337805	hsa-mir-15a	Carcinoma, Ductal, Breast	We aim to study whether miRNA-155 (miR-155), miR-19a and miR-15a can predict inherent RS according to cellular RS in breast cancer (BC) patients.
circulation_biomarker_diagnosis_up	35337805	hsa-mir-19a	Carcinoma, Ductal, Breast	However, miR-19a showed upregulation in the blood of BC patients.
circulation_biomarker_prognosis_up	35337261	hsa-mir-27a	Sepsis	CONCLUSIONS: This study showed that circulating miR-27a level is correlated with oxidative stress and mortality in patients with sepsis, and may serve as a potential non-invasive molecular biomarker.
target gene	35337159	hsa-mir-342	Osteosarcoma	Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells.
target gene	35337159	hsa-mir-491	Osteosarcoma	Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells.
target gene	35337095	hsa-mir-486	Lung Neoplasms	MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway.
transcription factor target	35336965	hsa-mir-192	Hypertrophy, Right Ventricular	The miR-192 family and miR-181a were capable of suppressing the RV infection via targeting of the Wnt/beta-catenin pathway.
transcription factor target	35336965	hsa-mir-181a	Hypertrophy, Right Ventricular	The miR-192 family and miR-181a were capable of suppressing the RV infection via targeting of the Wnt/beta-catenin pathway.
other	35336723	hsa-mir-10b	Ethylmalonic encephalopathy	A total of 16,534 circRNAs and 271 miRNAs (125 novel miRNAs and 146 annotated miRNAs) were screened, and 214 differentially expressed (DE) circRNAs and 53 DE miRNAs were detected between the AN and SE lambs (i.e., novel_circ_0025840, novel_circ_0022779, novel_miR_107, miR-10b).
other	35336723	hsa-mir-107	Ethylmalonic encephalopathy	A total of 16,534 circRNAs and 271 miRNAs (125 novel miRNAs and 146 annotated miRNAs) were screened, and 214 differentially expressed (DE) circRNAs and 53 DE miRNAs were detected between the AN and SE lambs (i.e., novel_circ_0025840, novel_circ_0022779, novel_miR_107, miR-10b).
other	35336723	hsa-mir-192	Ethylmalonic encephalopathy	Then, a two-step machine learning approach combining Random Forest (RF) and XGBoost (candidates were first selected by RF and further assessed by XGBoost) was performed, which identified 44 circRNAs and 39 miRNAs as potential biomarkers (i.e., novel_circ_0000180, novel_circ_0000365, novel_miR_192, oar-miR3p) for E.
transcription factor target	35336043	hsa-mir-155	Pulmonary Fibrosis	Overall, our data support the use of Chol-PCX as a carrier for anti-miR-155 for the combined therapeutic inhibition of CXCR4 and miR-155 expression as a way to improve fibrotic damage in the liver.
transcription factor target	35336043	hsa-mir-155	Liver Diseases, Alcoholic	Overall, our data support the use of Chol-PCX as a carrier for anti-miR-155 for the combined therapeutic inhibition of CXCR4 and miR-155 expression as a way to improve fibrotic damage in the liver.
transcription factor target	35334501	hsa-mir-126	Pulpitis	miR-126 may be a potential target to attenuate the inflammation of pulpitis.
circulation_biomarker_diagnosis_up	35334496	hsa-mir-21	Lung Neoplasms	circ_SAR1A was located predominantly in the cytoplasm; it inhibited lung cancer growth in vitro and in vivo by sponging to miR
circulation_biomarker_prognosis_ns	35334494	hsa-mir-20	Sepsis	CONCLUSIONS: The expression level of serum miR
circulation_biomarker_prognosis_ns	35334494	hsa-mir-20	Acute Kidney Injury	CONCLUSIONS: The expression level of serum miR
circRNA target	35334414	hsa-mir-21	Carcinoma, Pancreatic Ductal	Our study demonstrates that circ_0047744 acts as an anti-oncogene to inhibit PDAC metastasis by regulating the miR-21/SOCS5 axis, indicating that circ_0047744 may be a potential novel therapeutic target for PDAC patients.
transcription factor target	35334283	hsa-mir-126	Mesothelioma, Malignant	Autophagy is involved in these processes; miR-126 accumulation induced a protective autophagy and the inhibition of this process by GW4869 generates a metabolic crisis that promotes necroptosis, which was associated with PARP-1 over-expression and cyt-c and AIF release.
exosome	35334101	hsa-mir-1323	Uterine Cervical Neoplasms	Functional assays indicated that miR-1323 was transferred by cancer-associated fibroblasts-secreted (CAFs-secreted) exosomes and miR-1323 downregulation suppressed cell proliferation, migration, invasion, and increased cell radiosensitivity in CCa.
lncRNA target	35334070	hsa-mir-4652	Carcinoma, Non-Small-Cell Lung	5p targeted RND1 to modulate cell adhesion and the progression of LUSC cells.
genetics_knock down_suppress	35334040	hsa-mir-627	Glioma	CONCLUSION: Circ_RPPH1 knockdown inhibited glioma tumorigenesis by downregulating SDC1 by binding to miR
genetics_knock down_suppress	35334040	hsa-mir-663a	Glioma	CONCLUSION: Circ_RPPH1 knockdown inhibited glioma tumorigenesis by downregulating SDC1 by binding to miR
other	35333695	hsa-mir-23a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Restoration of miR-23a by chidamide may therefore have a therapeutic effect in controlling the sensitivity of CML cells to imatinib.
genetics_knock down_suppress	35333693	hsa-mir-1287	Carcinoma, Non-Small-Cell Lung	Circ_0008717 knockdown inhibited NSCLC tumorigenesis via miR
genetics_overexpression_promote	35332852	hsa-mir-125a	Uterine Cervical Neoplasms	Functionally, the overexpression of miR-125a greatly prevented the proliferation, migration and invasion of CSCC cells, and the inhibition of miR-125a expression strongly enhanced these behaviors in CSCC cells.
lncRNA target	35332770	hsa-mir-451a	Squamous Cell Carcinoma of Head and Neck	BACKGROUND: The miR-144/451a cluster acts as a tumor suppressor in various tumors by synergistically inhibiting the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC).
lncRNA target	35332770	hsa-mir-144	Squamous Cell Carcinoma of Head and Neck	BACKGROUND: The miR-144/451a cluster acts as a tumor suppressor in various tumors by synergistically inhibiting the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC).
genetics_overexpression_promote	35332577	hsa-mir-144	Rectal Neoplasms	CONCLUSIONS: Our data suggest that overexpression of miR-144/miR-451 cluster promotes LVI via repression of PTEN and p19 in rectal NET-G1 cells. miR-144/451 cluster may be a novel biomarker for predicting invasion/metastasis in rectal NET-G1.
lncRNA target	35332412	hsa-mir-762	Osteosarcoma	CONCLUSION: In this study, LncRNA BACE1-AS regulates proliferation, migration and invasion of osteosarcoma cells by miR-762/SOX7 axis, implying that LncRNA BACE1-AS is a potential target for osteosarcoma therapy.
tissue_expression_ns	35332065	hsa-mir-140	Craniofacial Abnormalities	miR-140 deficiency causes dwarfism and craniofacial deformity.
tissue_expression_ns	35332065	hsa-mir-140	Dwarfism	miR-140 deficiency causes dwarfism and craniofacial deformity.
tissue_expression_ns	35332065	hsa-mir-140	Warburg micro syndrome 1	miR-140 deficiency causes dwarfism and craniofacial deformity.
lncRNA target	35331106	hsa-mir-199b	Wounds and Injuries	CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS.
lncRNA target	35331106	hsa-mir-199b	Angelman Syndrome	CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS.
lncRNA target	35331106	hsa-mir-199b	Hyperlipidemias	CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS.
genetics_overexpression_promote	35330997	hsa-mir-520d	Osteosarcoma	miR-520d-3p overexpression suppressed the proliferation, migration, invasion, VM, and promotes the adhesion of OS cells in vitro.
lncRNA target	35330559	hsa-mir-182	Diabetes, Gestational	3p effectively alleviated the development of GDM through INSR1, suggesting a potential therapeutic strategy for GDM.
other	35330543	hsa-mir-196a	Liver Neoplasms	BACKGROUND: MiR-196a is particularly noticeable in the development of liver cancer.
genetics_knock down_promote	35329958	hsa-mir-22	Diabetic Neuropathies	Following a q-PCR-based analysis of total plasma microRNAs, we found that miR-92b-3p (p = 0.008) was significantly downregulated, while miR3p (p = 0.0001) was significantly upregulated in T2DM patients with corneal nerve loss.
genetics_knock down_promote	35329958	hsa-mir-92b	Diabetic Neuropathies	Following a q-PCR-based analysis of total plasma microRNAs, we found that miR-92b-3p (p = 0.008) was significantly downregulated, while miR3p (p = 0.0001) was significantly upregulated in T2DM patients with corneal nerve loss.
other	35328807	hsa-mir-451a	Ischemic Stroke	Moreover, in samples collected one month following stroke, we found sustained upregulation of hsa-miR-451a and downregulation of another 5 miRNAs.
other	35328750	hsa-mir-21	Lung Neoplasms	Data show the developed MB approach potential for miR5p detection in PBMCs from clinical samples towards NSCLC.
exosome	35328425	hsa-mir-21	Carcinoma, Renal Cell	Taken together, our results demonstrate that M2-Exos carries miR
other	35328424	hsa-mir-148a	Tuberculosis	Our data indicate that miR-148a may protect against tuberculous pleural fibrosis by regulating NOX4 and POLDIP2.
other	35328400	hsa-mir-183	Obesity	5p plays a crucial role in the pathogenesis of hepatic insulin resistance in the background of obesity.
other	35328400	hsa-mir-183	Insulin Resistance	5p plays a crucial role in the pathogenesis of hepatic insulin resistance in the background of obesity.
other	35328383	hsa-mir-21	Lung Neoplasms	To demonstrate its usefulness, we chose miR-21, which is upregulated and implicated in lung cancer. We constructed a miR-21 sponge and inserted it into a vector that facilitates circular RNA production (Circ-21) to study its effect on growth, colony formation, and migration in lung cancer cell lines and multicellular tumor spheroids (MTS).
other	35328346	hsa-mir-96	Prostatic Neoplasms	5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells.
other	35328346	hsa-mir-34a	Prostatic Neoplasms	5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells.
other	35328346	hsa-mir-99b	Prostatic Neoplasms	5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells.
lncRNA target	35328298	hsa-mir-126	Breast Neoplasms	Overall, our study suggests that miR-126 might play a tumor suppressor role in ER+ BC.
other	35328182	hsa-let-7a	Lymphoma, Non-Hodgkin	We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD.
other	35328182	hsa-mir-124	Lymphoma, Non-Hodgkin	We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD.
circulation_biomarker_diagnosis_ns	35328059	hsa-mir-17	Alopecia Areata	We evaluated, for the first time, the miR92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR.
other	35328023	hsa-mir-185	Chronic Disease	Emerging evidence implicates miR5p in chronic inflammation diseases.
other	35327987	hsa-mir-27b	Sleep Apnea, Obstructive	miR-27b-3p decreased in OSAs and ESCs.
lncRNA target	35327612	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	Furthermore, miR-34a induces senescence and apoptosis in breast, glioma, cervical cancer including NSCLC by targeting Myc.
other	35327520	hsa-mir-181a	Fetal Growth Retardation	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-20a	Fetal Growth Retardation	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-145	Pre-Eclampsia	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-20a	Pre-Eclampsia	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-574	Pre-Eclampsia	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-146a	Pre-Eclampsia	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-342	Cardiovascular Diseases	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-146a	Fetal Growth Retardation	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-145	Fetal Growth Retardation	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-20a	Cardiovascular Diseases	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-146a	Cardiovascular Diseases	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-181a	Pre-Eclampsia	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-181a	Cardiovascular Diseases	3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-145	Cardiovascular Diseases	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-342	Pre-Eclampsia	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-342	Fetal Growth Retardation	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-574	Cardiovascular Diseases	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
other	35327520	hsa-mir-574	Fetal Growth Retardation	3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation.
lncRNA target	35327465	hsa-mir-133b	Squamous Cell Carcinoma of Head and Neck	3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens.
lncRNA target	35327465	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens.
lncRNA target	35327465	hsa-mir-133a	Squamous Cell Carcinoma of Head and Neck	3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens.
lncRNA target	35327465	hsa-mir-206	Squamous Cell Carcinoma of Head and Neck	3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens.
other	35327461	hsa-mir-7	Melanoma	Acidification of metastatic melanoma environment made EVs more prooncogenic with increased expression of prooncogenic mi221 RNA, stemless factor CD133, and pro-migration factor SNAI1, as well as with downregulated antitumor mir7 RNA.
lncRNA target	35327430	hsa-let-7d	Pulmonary Arterial Hypertension	RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels.
lncRNA target	35327430	hsa-mir-26	Scleroderma, Systemic	RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels.
lncRNA target	35327430	hsa-mir-26	Pulmonary Arterial Hypertension	RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels.
lncRNA target	35327430	hsa-let-7d	Scleroderma, Systemic	RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-4454	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-181a	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. Circulating miRNAs showed a tendency to increase in obese subjects, except for miR-181a expression.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-142	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-199a	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-223	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed.
circulation_biomarker_diagnosis_ns	35327332	hsa-mir-33a	Pediatric Obesity	To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed.
other	35326280	hsa-mir-155	Glioma	A significant correlation was found between the miR-155 concentration and the level of PD-L1 expression in p-HGG tumor tissue.
transcription factor target	35325806	hsa-mir-33a	Abortion, Habitual	MiR-33a, miR-33b, and miR-181a were reduced in the placenta from patients with RPL, which were identified to repress S1PR1 expression by targeting the 3'UTR.
transcription factor target	35325806	hsa-mir-181a	Abortion, Habitual	MiR-33a, miR-33b, and miR-181a were reduced in the placenta from patients with RPL, which were identified to repress S1PR1 expression by targeting the 3'UTR.
lncRNA target	35325570	hsa-mir-765	Breast Neoplasms	In this study, we prove that LINC00982 regulates the growth and development of BC through STAT3/NF-kappaB signal pathway, mediated by the miR-765/DPF3 axis.
lncRNA target	35325441	hsa-mir-365a	Inflammation	In conclusion, lncRNA NEAT1 was involved in AP progression by sponging miR-365a-3p and may thus be a novel target for treating patients with AP.
lncRNA target	35325441	hsa-mir-365a	Pancreatitis	In conclusion, lncRNA NEAT1 was involved in AP progression by sponging miR-365a-3p and may thus be a novel target for treating patients with AP.
genetics_knock down_promote	35324917	hsa-mir-21	De Lange Syndrome	The miR-21 inhibitor decreased IL-10 levels in culture supernatants from splenic leukocytes in the CanL group.
other	35324773	hsa-mir-221	Carcinoma, Pancreatic Ductal	Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased.
other	35324773	hsa-mir-126	Carcinoma, Pancreatic Ductal	Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased.
other	35324773	hsa-mir-155	Carcinoma, Pancreatic Ductal	Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased.
lncRNA target	35324533	hsa-mir-30	Thyroid Neoplasms	circ_0058063 can act as a carcinogen in cases with TC via the miR
lncRNA target	35324527	hsa-mir-657	Retinoblastoma	miR-657 enhanced the retinoblastoma tumorigenesis by directly inhibiting PPARA expression, suggesting that PPARA targeting by miR-657 facilitates retinoblastoma development by enhancing cell growth.
lncRNA target	35324526	hsa-mir-361	Pituitary Neoplasms	3p-mediated cell invasion, proliferation and apoptosis in BBOX1-AS1-dysregulated pituitary adenoma cells in rescue tests.
lncRNA target	35324519	hsa-mir-429	Thyroid Cancer, Papillary	Downregulation of RNF185-AS1 may suppress PTC progression through functioning as a sponge of miR-429 to hinder the expression of LRP4. The RNF185-AS1/miR-429/LRP4 axis will lay the groundwork for future therapeutic strategies in PTC.
other	35324518	hsa-mir-485	Carcinoma, Non-Small-Cell Lung	CONCLUSION: CircFOXK2 sponged miR5p to stimulate PD-L1 and expedited NSCLC development.
genetics_overexpression_suppress	35324517	hsa-mir-1207	Colorectal Neoplasms	Overexpression of miR
lncRNA target	35322864	hsa-mir-205	Intervertebral disc disease	These results suggested that targeting LINC00284 to rescue miR2053p expression may be a potential method for IDD management.
genetics_overexpression_promote	35322757	hsa-mir-29a	Non-alcoholic Fatty Liver Disease	Moreover, GAS5 overexpression enhanced NOTCH2 levels in liver cells and promoted NAFLD progression by sponging miR-29a-3p in vivo.
lncRNA target	35322738	hsa-mir-21	Inflammation	Taken together, we can conclude that MEG3 mediates inflammation, oxidative stress and apoptosis in TNF-alpha-treated ICC via the miR-21/IKKB-NF-kappaB axis.
genetics_knock down_promote	35322736	hsa-mir-142	Osteoarthritis	5p, and circ_0005526 knockdown suppressed IL-1beta-induced OA progression through upregulating miR
lncRNA target	35322735	hsa-mir-627	Hepatitis B	Together, our data suggest that HMMR-AS1 regulates HBV-HCC progression via miR
lncRNA target	35322735	hsa-mir-627	Carcinoma, Hepatocellular	Together, our data suggest that HMMR-AS1 regulates HBV-HCC progression via miR
genetics_knock down_promote	35322553	hsa-mir-29b	Ischemic Stroke	CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.
lncRNA target	35322532	hsa-mir-126	Adenocarcinoma of Lung	5p downregulated EZH2 to facilitate the sensitivity of lung adenocarcinoma cells to radiotherapy via KLF2/BIRC5.
genetics_overexpression_suppress	35322290	hsa-mir-29b	Atrial Fibrillation	TGFbetaRIota overexpression overcame the improving effect of miR-29b overexpression on AF.
genetics_overexpression_suppress	35322290	hsa-mir-29b	Fibrosis, Atrial	TGFbetaRIota overexpression overcame the improving effect of miR-29b overexpression on AF.
genetics_knock down_promote	35322289	hsa-mir-579	Esophageal Squamous Cell Carcinoma	Furthermore, the inhibitory effects of circ_0001093 knockdown on the invasion, migration and glutamine metabolism were partly rescued by miR
lncRNA target	35321971	hsa-mir-9a	Arthritis, Rheumatoid	We further showed that miR-9a-5p specifically interacts with KLF7 to negatively regulate the expression of KLF7 in RA-FLSs. Taken together, our results demonstrated that KLF7 which targeted by miR-9a-5p might participate in the pathogenesis of RA by promoting cell proliferation, pro-inflammatory cytokine release and MMP expression through the activation of NF-kappaB and JNK pathways in RA-FLSs.
other	35321689	hsa-mir-335	Urinary Bladder Neoplasms	5p.
circulation_biomarker_diagnosis_down	35321519	hsa-mir-485	Osteoporosis	The plasma expression levels of miR
circulation_biomarker_diagnosis_down	35321519	hsa-mir-491	Osteoporosis	The plasma expression levels of miR
target gene	35321435	hsa-mir-4291	Uterine Cervical Neoplasms	Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis.
target gene	35321434	hsa-mir-192	Prostatic Neoplasms	BK002 Induces miR-192-5p-Mediated Apoptosis in Castration-Resistant Prostate Cancer Cells via Modulation of PI3K/CHOP.
circulation_biomarker_diagnosis_up	35321390	hsa-mir-122	Hepatitis B, Chronic	Finally, it was found that the miR-122 serum concentration correlated with HBV DNA and serum ALT (p=0.001).
transcription factor target	35321102	hsa-mir-194	Cardiotoxicity	CONCLUSION: Our findings revealed that silencing miR5p could alleviate DOX-induced cardiotoxicity via PAK2 and XBP1s in vitro and in vivo.
other	35321102	hsa-mir-194	Heart Diseases	Silencing of miR5p also improved DOX-induced cardiac dysfunction.
other	35321102	hsa-mir-194	Myocardial Infarction	MiR5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is still unclear.
other	35321102	hsa-mir-194	Cardiomyopathies	MiR5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is still unclear.
exosome	35321026	hsa-mir-761	Endometriosis	CONCLUSION: Exosomal HOTAIR promoted the progression and angiogenesis of endometriosis by regulating the miR-761/HDAC1 axis and activating STAT3-mediated inflammation in vitro and in vivo, which may provide promising treatment for endometriosis.
lncRNA target	35321017	hsa-mir-1251	Hirschsprung Disease	The novel RMST/SOX2/miR-1251/AHNAK axis provided potential targets for the diagnosis and treatment of HSCR during embryonic stage.
circRNA target	35320976	hsa-mir-589	Stomach Neoplasms	We also showed that circCASP9 can regulate the growth and metastasis of GC via the miR
lncRNA target	35320950	hsa-mir-1271	Carcinoma, Renal Cell	In addition, we explored the relationship between the crucial genes and TIICs via coexpression analysis, which revealed that the interactions between MALAT1, miR
other	35320929	hsa-mir-101	Thyroid Cancer, Papillary	3p axis in the setting of LUAD and suggests diagnostic and therapeutic biomarkers potentially useful in the clinical management of this illness.
other	35320929	hsa-mir-101	Adenocarcinoma of Lung	3p axis in the setting of LUAD and suggests diagnostic and therapeutic biomarkers potentially useful in the clinical management of this illness.
other	35320579	hsa-mir-106b	Infertility, Male	In conclusion, our findings showed that miR-106b-5p enhances the proliferative potential of SSCs, making it a substantial factor for therapeutic strategies of male infertility.
genetics_knock down_promote	35320491	hsa-mir-338	Siderosis	3p inhibitor and SLC1A5 overexpression vectors were delivered into the RPE cells, and the following gain- and loss-of-function experiments validated that both miR
other	35320453	hsa-mir-125b	Breast Neoplasms	MiR-125b-5p/TPD52 Axis Affects Proliferation, Migration and Invasion of Breast Cancer Cells.
exosome	35319370	hsa-mir-210	Brain Ischemia	CONCLUSION: EA treatment could activate the HIF-1alpha/VEGF/Notch 1 signal pathway to facilitate angiogenesis after ischemic stroke via exosomal miR-210.
genetics_knock down_promote	35319228	hsa-mir-155	Inflammatory Bowel Diseases	5p inhibitors, whereas knockdown of GATA3 by RNA interference enhanced IBDV growth, and this enhancement could be blocked with gga-miR
lncRNA target	35319228	hsa-mir-155	Fused Teeth	5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens.
lncRNA target	35319228	hsa-mir-155	Bird Diseases	5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens.
target gene	35319228	hsa-mir-155	Immune System Diseases	IMPORTANCE Gga-miR5p acts as an important antivirus factor against IBDV infection, which causes a severe immunosuppressive disease in chicken.
lncRNA target	35319228	hsa-mir-155	Bursitis	5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens.
lncRNA target	35319018	hsa-mir-16	Breast Neoplasms	We found that tumor hypoxia can transcriptionally induce HIF1alpha and post-transcriptionally inhibit the expression of miR5p to promote YTHDF1 expression, which could sequentially enhance tumor glycolysis by upregulating PKM2 and eventually increase the tumorigenesis and metastasis potential of breast cancer cells.
transcription factor target	35319011	hsa-mir-23a	Colorectal Neoplasms	MiR-323a-3p promotes CRC cells apoptosis by targeting ErbB3-phosphoinositide 3-kinases (PI3K)/PKB protein kinase (Akt)/glycogen synthase kinase 3 beta (GSK3beta)/EGFR-extracellular regulated MAP kinase (Erk1/2) signaling directly. MiR-323a-3p reverses ErbB3/EGFR signaling activation in gefitinib-resistant CRC cell lines and blocks acquired gefitinib resistance.
circulation_biomarker_diagnosis_ns	35318442	hsa-mir-409	Neuroblastoma	MiRNA5p interacted with HNF4A-AS1 to facilitate sPEP1 translation via recruiting eukaryotic translation initiation factor 3 subunit G, while sPEP1 repressed serum deprivation-induced senescence and promoted sphere formation, growth, or metastasis of NB stem cells.
other	35318393	hsa-mir-16	Uterine Cervical Neoplasms	miR-16 has been shown to influence autophagy in cervical cancer.
target gene	35318311	hsa-mir-542	Breast Neoplasms	CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1α axis.
lncRNA target	35318304	hsa-mir-508	Endometrial Neoplasms	5p/SOX2 axis has potential value in modulating ECSC maintenance, chemoresistance, and tumorigenesis in EC, which highlights a novel promising target for EC treatment.
circRNA target	35318303	hsa-mir-198	Prostatic Neoplasms	The consequences of high-dose-DHT suppressed circRNA-BCL2/miRNA-198/AMBRA1 signaling likely result in induction of the autophagic cell death to suppress the EnzR CRPC cell growth.
lncRNA target	35317841	hsa-mir-346	Prostatic Neoplasms	Importantly, miR-346 sensitises PC cells to DNA-damaging drugs including PARP inhibitor and chemotherapy, and induces tumour regression as a monotherapy in vivo, indicating that targeting miR-346:NORAD balance is a valid therapeutic strategy.
lncRNA target	35317822	hsa-mir-874	Endometrial Neoplasms	3p to regulate EMT in endometrial cancer via the miR
transcription factor target	35317779	hsa-mir-106b	Esophageal Squamous Cell Carcinoma	Furthermore, miR-106b-5p inhibited HPGD expression, thereby suppressing ESCC tumorigenesis.
circulation_biomarker_diagnosis_up	35317728	hsa-mir-20	Emergence Delirium	Compared with NPOD patients, the expressions of plasma miR-320 and APP protein were increased and the expression of plasma IGF-1 mRNA was decreased in POD patients after surgery.
circulation_biomarker_prognosis_ns	35317445	hsa-mir-200a	Carcinoma, Non-Small-Cell Lung	Collectively, it was revealed that miR-200a-3p and GATA6 were abnormally expressed in the peripheral blood of patients with NSCLC.
genetics_knock down_promote	35317442	hsa-mir-1205	salivary gland adenoid cystic carcinoma	The knockdown of hsa_circ_0011946 expression inhibited the proliferation, invasion and migration of SACC cells, thereby inhibiting the EMT process, which was achieved by downregulating miR-1205 expression.
genetics_overexpression_suppress	35317439	hsa-mir-150	ankylosing spondylitis 1	5p overexpression decreased osteogenic transformation of fibroblasts by decreasing VDR expression in AS.
circulation_biomarker_diagnosis_down	35317427	hsa-mir-129-1	Stomach Neoplasms	1-3p was significantly down-regulated in GC compared to AG (P = 0.0021 and P = 0.024, tissue and plasma, respectively).
other	35317427	hsa-mir-215	Stomach Neoplasms	Moreover, analysis revealed that hsa-miR3p/5p and hsa-miR-934 were significantly deregulated in GC based on Helicobacter pylori (H.
other	35317427	hsa-mir-934	Stomach Neoplasms	Moreover, analysis revealed that hsa-miR3p/5p and hsa-miR-934 were significantly deregulated in GC based on Helicobacter pylori (H.
other	35317418	hsa-mir-132	Fetal Growth Retardation	Further studies are needed to investigate the role of miR-132 in the management of late-onset FGR.
lncRNA target	35317281	hsa-mir-10b	Arthritis	Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4(+) T cells. The present findings suggest that miR-10b could disrupt the balance of CD4(+) T subsets, while suppressed miR-10b could attenuate the severity of experimental arthritis, which provided us a novel mechanistic and therapeutic insight into the RA.
exosome	35317202	hsa-mir-652	Breast Neoplasms	synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state.
exosome	35317202	hsa-mir-1246	Breast Neoplasms	synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state.
exosome	35317202	hsa-mir-185	Breast Neoplasms	synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state.
circulation_biomarker_diagnosis_up	35316914	hsa-mir-21	Enterocolitis, Necrotizing	MATERIAL AND METHODS: Collecting 30 pairs of newborn and NEC children and measuring the miRNA-21 expression in the serum of 30 pairs.
transcription factor target	35316906	hsa-mir-29b	Pre-Eclampsia	CONCLUSIONS: The down-regulation of miR-29b-3p could improve HTR-8/SVneo cell biological activities in a preeclampsia cell model by targeting B2R.
circulation_biomarker_diagnosis_up	35316895	hsa-mir-18a	Polycystic Ovary Syndrome	MATERIAL AND METHODS: Real-time PCR was performed to compare the levels of irisin, blood glucose, UCA1 and miR-18a among PCOS, PCOS Met, and control groups using area under curve (AUC) values.
other	35316894	hsa-mir-29b	Dmd-Associated Dilated Cardiomyopathy	Except for a single measurement of miR-29b at 3 months (DCM with fibrosis: 6.03 0.72 vs. DCM without fibrosis: 6.4 0.75 Cq; p &lt; 0.05), baseline, 3- and 12-month kinetics of microRNAs did not differ between the two groups.
other	35316894	hsa-mir-29	Dmd-Associated Dilated Cardiomyopathy	Except for a single measurement of miR-29b at 3 months (DCM with fibrosis: 6.03 0.72 vs. DCM without fibrosis: 6.4 0.75 Cq; p &lt; 0.05), baseline, 3- and 12-month kinetics of microRNAs did not differ between the two groups.
lncRNA target	35316874	hsa-mir-4484	Stomach Neoplasms	Both miR-4484 and ITGA6 may be the new prognostic markers and potential therapeutic targets of gastric cancer.
lncRNA target	35316873	hsa-mir-153	Lymphoma, Large B-Cell, Diffuse	Conclusion: Down-regulation of circZNF609 inhibits the proliferation of diffuse large B-cell lymphoma OCI-LY19 cells and induces apoptosis by targeting miR-153.
exosome	35316648	hsa-mir-9	Spinal Cord Injuries	In conclusion, our findings indicated that exosomal miR
circulation_biomarker_diagnosis_ns	35316486	hsa-mir-152	Histiocytic Sarcoma	After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations.
circulation_biomarker_diagnosis_ns	35316486	hsa-mir-143	Histiocytic Sarcoma	After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations.
circulation_biomarker_diagnosis_ns	35316486	hsa-mir-27a	Histiocytic Sarcoma	After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations.
genetics_overexpression_suppress	35316152	hsa-mir-376a	Leukemia, Myeloid, Acute	The rescue experiments further confirmed that miR-376a-3p could reverse the promotion of MT1X overexpression on the progress of AML cells.
lncRNA target	35316129	hsa-mir-182	Triple Negative Breast Neoplasms	CONCLUSION: SLC16A1-AS1 may inhibit cell cycle progression and restrain TNBC cell proliferation by regulating the miR-182/PDCD4 axis.
genetics_overexpression_suppress	35315499	hsa-mir-450b	Myocardial Reperfusion Injury	Subsequently, the regulatory mechanism underlying the lncRNA SNHG1/miR450b5p/IGF1 axis in MIRI was investigated by overexpressing miR450b5p and knocking down IGF1 expression in H/Rinduced cells.
lncRNA target	35315366	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	Therefore, we believe that APS could inhibit the proliferation and migration of NSCLC cells by regulating miR
exosome	35315295	hsa-mir-424	Squamous Cell Carcinoma of Head and Neck	ER-stressed HNSCC cell-induced exosomal miR5p inhibits angiogenesis and migration of HUVEC cells through LAMC1-mediated Wnt/beta-catenin signaling pathway.
genetics_GWAS	35315037	hsa-mir-146a	Stomach Neoplasms	The rs2910164 polymorphism of the miR-146a gene may reduce the risk of gastric cancer by influencing the processing of mature miR-146a.
genetics_overexpression_promote	35314531	hsa-mir-152	Cystadenocarcinoma, Serous, Endometrial	MiR-152 overexpression increased apoptosis and inhibited the proliferation of the two ESC cell lines.
other	35314529	hsa-let-7d	Glomerulonephritis, IGA	Here, hsa-miR-451a and hsa-let-7d-3p were upregulated in IgAN patients compared with healthy controls. These findings suggest that hsa-miR-451a and hsa-let-7d-3p may serve as noninvasive biomarkers for the evaluation of IgAN.
other	35314529	hsa-mir-451a	Glomerulonephritis, IGA	Here, hsa-miR-451a and hsa-let-7d-3p were upregulated in IgAN patients compared with healthy controls. These findings suggest that hsa-miR-451a and hsa-let-7d-3p may serve as noninvasive biomarkers for the evaluation of IgAN.
circulation_biomarker_diagnosis_ns	35314361	hsa-mir-24	Dermatitis, Atopic	The plasma miR-24 and miR-191 levels of the AD patients were correlated with their serum thymus and activation-regulated chemokine levels.
circulation_biomarker_diagnosis_ns	35314361	hsa-mir-191	Dermatitis, Atopic	The plasma miR-24 and miR-191 levels of the AD patients were correlated with their serum thymus and activation-regulated chemokine levels.
other	35313857	hsa-let-7d	Carcinoma, Non-Small-Cell Lung	LUSC patients with high let-7d-3p expression had poor overall survival rates (OS).
circulation_biomarker_diagnosis_ns	35313857	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	5p in peripheral blood of NSCLC patients was higher than the healthy controls.
lncRNA target	35313857	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	3p, and hsa-let-7d-3p) were screened from 3 databases, and 6 upstream transcription factors and 2253 downstream target genes were predicted.
lncRNA target	35313857	hsa-mir-28	Carcinoma, Non-Small-Cell Lung	3p, and hsa-let-7d-3p) were screened from 3 databases, and 6 upstream transcription factors and 2253 downstream target genes were predicted.
lncRNA target	35313796	hsa-mir-23a	Medulloblastoma	We identified GLS (glutaminase), a glutamine metabolism enzyme, was directly targeted by miR-23a-3p in MB cells.
other	35313568	hsa-mir-133b	Stomach Neoplasms	CONCLUSION: Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.
genetics_overexpression_promote	35313299	hsa-mir-199a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Both miR-199a-3p overexpression and mTOR silencing inhibited CML cell proliferation, promoted CML cell apoptosis, and sensitized these cells to imatinib.
lncRNA target	35313261	hsa-mir-493	Ovarian Neoplasms	3p through targeting DPY30 in ovarian cancer, indicating that miR
circulation_biomarker_diagnosis_ns	35313225	hsa-mir-204	Pre-Eclampsia	5p levels were higher in PE serum.
lncRNA target	35313071	hsa-mir-575	Head and Neck Neoplasms	Collectively, our study provides mechanistic insights into the role of DRP1 in HNC and highlights the potential of targeting the miR-575/DRP1/FOXM1/MMP12 axis as a novel therapy for the prevention of HNC progression.
genetics_knock down_promote	35312836	hsa-mir-145	Colorectal Neoplasms	Moreover, proliferation, clone formation, and apoptosis in CRC cells treated with 5-FU were assessed after gain- or loss-of-function of ATF4, miR-145, and/or HDAC4.
other	35312280	hsa-mir-342	Triple Negative Breast Neoplasms	3p in the miRNA-extracts from cancer cell lines and TNBC patient-derived xenografts.
genetics_knock down_promote	35312228	hsa-mir-21	Osteoporosis	After confirming that miR-21 deficiency retards the beta1/2-AR agonist isoproterenol (ISO)-induced osteopenia, it is shown that the pharmacological inhibition of exosome release by two clinically-relevant drugs, dimethyl amiloride and omeprazole, suppresses osteoblastic miR-21 transfer and ameliorates bone loss under both ISO and chronic variable stress (CVS)-induced depression conditions. A targeted delivery approach to specifically silence osteoblastic miR-21 is further applied, which is effective in rescuing the bone remodeling balance and ameliorating ISO- and CVS-induced osteopenias.
lncRNA target	35312153	hsa-mir-140	Acute Kidney Injury	These results cumulatively show that HIF-1alpha regulates mitophagy during AKI through the regulation of miR
circRNA target	35312115	hsa-mir-494	Esophageal Squamous Cell Carcinoma	CONCLUSION: Circ_0007142 improved DDP resistance of ESCC by upregulating LASP1 via sponging miR3p.
other	35312113	hsa-mir-1294	Uterine Cervical Neoplasms	CONCLUSION: Hsa_circ_0018289 contributes to malignant development by regulating the miR-1294/ICMT axis, affording novel insight into CC therapy.
lncRNA target	35311623	hsa-mir-424	Stomach Neoplasms	5p/Smad7 axis and thus could be a promising target for GC therapy.
lncRNA target	35311457	hsa-mir-587	Carcinoma, Ovarian Epithelial	Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting results showed that ADAMTS9-AS1 expression was elevated in EOC cells; microRNA-587 expression was up-regulated and SLC7A11 expression was down-regulated after knocking down ADAMTS9-AS1 by transfection with siRNAs; however, microRNA-587 inhibitor reversed SLC7A11 expression in ADAMTS9-AS1 knocking down cells. In conclusion, our study found that ADAMTS9-AS1 attenuated ferroptosis by targeting miR-587/SLC7A11 axis in EOC.
lncRNA target	35311456	hsa-mir-1305	Uterine Cervical Neoplasms	In conclusion, circ_0072008 facilitated CESC cell proliferation, migration, and invasion through increasing HELLS expression by regulating miR-1305, which also offered an underlying targeted therapy for CESC treatment.
genetics_GWAS	35311447	hsa-mir-1	Urinary Bladder Neoplasms	We also focused on the role of epigenetics in bladder tumors and verified that KRT6A was a miR
lncRNA target	35311115	hsa-mir-29a	Acute Lymphoblastic Leukemia, B-Cell	Through bioinformatics analyses and RT-qPCR validation, the lncRNA DUXAP8/miR-29a/PIK3CA network and PI3K-AKT-mTOR signaling were identified as significantly associated with B-ALL chemotherapy resistance. CONCLUSION: Targeting the lncRNA DUXAP8/miR-29a/PIK3CA network not only induced an apoptotic effect on Dox-resistant B-ALL and restored Dox chemosensitivity via PI3K-AKT-mTOR signaling but also showed synergism with inotuzumab ozogamicin treatment.
other	35311096	hsa-mir-211	Retinoblastoma	5p promotes carboplatin resistance in human retinoblastoma Y79 cells, and this process can be affected by GDNF-LIF interaction.
genetics_knock down_suppress	35310934	hsa-mir-590	Alzheimer Disease	Our results showed that knockdown of miR
lncRNA target	35310933	hsa-mir-181a	Osteosarcoma	Moreover, we observed that miR-181a-5p mimic further inhibited growth of human osteosarcoma cells in the presence of adriamycin or cisplatin.
genetics_overexpression_promote	35310917	hsa-mir-217	Uterine Cervical Neoplasms	The investigation of the mechanism showed that hsa-miR-217 silencing or HIF-1a overexpression rescued hsa_circ_0004543, and silencing inhibited malignant phenotypes of CC cells.
lncRNA target	35310916	hsa-mir-1178	Carcinoma, Non-Small-Cell Lung	3p sponge by targeting APITD1 that alleviated NSCLC progression.
other	35310909	hsa-mir-140	Ovarian Neoplasms	The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built.
other	35310909	hsa-mir-429	Ovarian Neoplasms	The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built.
other	35310909	hsa-mir-199a	Ovarian Neoplasms	The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built.
lncRNA target	35310907	hsa-mir-1251	Carcinoma, Renal Cell	5p constrained ccRCC cell advancement, migration, and immune evasion via targeting NPTX2, providing novel insights into ccRCC target treatment.
circulation_biomarker_diagnosis_ns	35310355	hsa-mir-182	Glioma	As a result, it could quantify miRNA-182 in serum of glioma patients, the concentration of which was significantly higher than that of healthy people and obviously decreased after surgery.
lncRNA target	35310196	hsa-mir-195	Squamous Cell Carcinoma of Head and Neck	miR-195 blocks the NF-kappaB pathway via inhibiting the expression of TLR4 in OSCC cells, thereby exerting an antitumor effect.
lncRNA target	35309842	hsa-mir-217	Carcinoma, Hepatocellular	inhibitor-transfected HCC cells were distinctly enhanced and the apoptosis rate (flow cytometry) was noticeably reduced.
other	35309364	hsa-mir-203a	Sjogren's Syndrome	When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients.
other	35309364	hsa-mir-181b	Sjogren's Syndrome	When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients.
other	35309364	hsa-mir-181a	Sjogren's Syndrome	When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients.
transcription factor target	35309179	hsa-mir-340	Breast Neoplasms	Taken together, sinomenine inhibits hypoxia-caused VM formation and metastasis of breast cancer SP cells by regulating the miR5p/SIAH2 axis.
lncRNA target	35309146	hsa-mir-1291	Intervertebral Disc Degeneration	In the DEMis-DEMs network of IDD, miR-1291, miR-4270, and miR-320b had high connectivity with targeted DEMs. The area under the curve (AUC) of 10 DEMs including miR-1273e, miR-623, miR-518b, and miR-1291 in ROC analysis was more than 0.8, which indicated that those 10 DEMs had diagnostic value in distinguishing IDD from normal individuals.
circulation_biomarker_diagnosis_ns	35309127	hsa-mir-105	Esophageal Squamous Cell Carcinoma	5p entered ESCC cells and promoted tumor-relevant functions by mediating SPARCL1 and the FAK/Akt signaling pathway, which indicated that the treatment of ESCC via serum EVs might be a novel therapy and that miRNA
other	35309118	hsa-mir-195	Carcinoma, Hepatocellular	Overall, the hsa_circ_0017264-hsa-miR5p-CHEK1/CDC25A/FOXK1 network might provide novel insights into the potential mechanisms underlying LIHC onset and progression.
target gene	35309116	hsa-mir-429	Stomach Neoplasms	Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429.
genetics_GWAS	35309115	hsa-mir-608	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
genetics_GWAS	35309115	hsa-mir-26	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
genetics_GWAS	35309115	hsa-mir-100	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
genetics_GWAS	35309115	hsa-let-7a-1	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
genetics_GWAS	35309115	hsa-mir-499	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
genetics_GWAS	35309115	hsa-mir-423	Tuberculosis	The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population.
other	35309064	hsa-mir-224	Abortion, Habitual	CONCLUSION: In this study, we found that circ-CYP24A1 plays a role in RM by impairing the balance of cell proliferation and apoptosis by sponging miR-224, thereby regulating PRLR.
other	35308338	hsa-mir-164	CLAPO Syndrome	The primary miR164-NAC1 network is potentially involved in plant defense responses against CLas from the early infection stage to symptom development.
circRNA target	35308166	hsa-mir-183	Thyroid Neoplasms	Initial results revealed that circRNA_0057209 and STK4 were both reduced, while miR-183 was up-regulated in thyroid cancer tissues and cells. Altogether, our findings indicated that circRNA_0057209 may serve as a competing endogenous RNA of miR-183 to increase STK4 expression, thus inhibiting the development of thyroid cancer.
genetics_overexpression_promote	35307984	hsa-mir-10b	Esophageal Neoplasms	CONCLUSIONS: Overexpression of circATIC hampered ESCA progression and promoted radiosensitivity depending on the regulation of miR-10b-3p and RHCG.
lncRNA target	35307914	hsa-mir-4742	Carcinoma, Non-Small-Cell Lung	In conclusion, LINC01140 inhibited NSCLC progression and cisplatin resistance via functioning as a ceRNA for miR
other	35307828	hsa-mir-29	Cognition Disorders	This study also examined the prevalence of variants at the miR-29 binding site of COL4A1 in 73 Finnish VCI patients.
genetics_overexpression_promote	35307709	hsa-mir-942	Carcinoma, Renal Cell	Besides that, propofol decreased miR-942 expression, and miR-942 overexpression attenuated the effects of propofol on ccRCC cells.
epigenetics	35307582	hsa-mir-451	Leukemia, Myeloid, Acute	In the future, we will continue to include more cases and exclude the others factor influencing ABO antigen expression, promoter methylation and oxidative stress, to replicate the results of this study and investigate the underlying mechanism of decreasing miR-16 and miR-451 in AML patients with varied ABO antigen expression levels.
epigenetics	35307582	hsa-mir-16	Leukemia, Myeloid, Acute	In the future, we will continue to include more cases and exclude the others factor influencing ABO antigen expression, promoter methylation and oxidative stress, to replicate the results of this study and investigate the underlying mechanism of decreasing miR-16 and miR-451 in AML patients with varied ABO antigen expression levels.
lncRNA target	35307379	hsa-mir-30	Osteosarcoma	Through in vivo experiments, we further confirmed that circ_0078767 targeted miR
genetics_knock down_promote	35307327	hsa-mir-100	Carcinoma, Non-Small-Cell Lung	HAGLROS repressed miR-100 expression to promote SMARCA5 expression in NSCLC cells, and miR-100 overexpression or SMARCA5 knockdown counteracted the oncogenic functions of HAGLROS. CONCLUSIONS: These results conclude that HAGLROS is a tumor promoter in NSCLC, and it regulates the malignant phenotypes of NSCLC cells via miR-100/SMARCA5 axis.
lncRNA target	35307061	hsa-mir-499	Cardiomyopathies	Targeted regulation of miR-499 expression may be an effective way to treat SMD.
other	35306965	hsa-mir-543	Nasopharyngeal Carcinoma	CONCLUSION: CP restrains the growth, migration and invasion of NPC cells and is negatively regulated by miR-543.
target gene	35306579	hsa-mir-93	Ovarian Neoplasms	miR-93-5p suppresses ovarian cancer malignancy and negatively regulate CCND2 by binding to its 3'UTR region.
genetics_overexpression_promote	35306563	hsa-mir-22	Carcinoma, Hepatocellular	3p inhibition or YARS overexpression partially blocked the function of NCK1-AS1 deficiency in HCC cells.
circRNA target	35306484	hsa-mir-214	Cardiomegaly	CONCLUSIONS: Our data demonstrated that circRNA_0001006 exacerbates cardiac hypertrophy via suppressing miR3p leading to enhanced PAK6 levels.
genetics_overexpression_promote	35306455	hsa-mir-141	Brain Injuries	3p overexpression alleviated ICH-induced brain injury and protected BBB integrity in vivo.
genetics_overexpression_promote	35306455	hsa-mir-141	Cerebral Hemorrhage	3p overexpression alleviated ICH-induced brain injury and protected BBB integrity in vivo.
circulation_biomarker_diagnosis_up	35306433	hsa-mir-17	Diabetes, Gestational	5p was upregulated in human GDM plasma and placentas along with the reduced Mfn1/Mfn2.
lncRNA target	35306368	hsa-mir-7	Stomach Neoplasms	PURPOSE: To investigate the molecular mechanism and effects of BAI inhibiting progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
other	35306280	hsa-mir-155	Hepatitis B	CONCLUSIONS: Thus, MALAT1 may play an important role in NK cell-mediated immunity in TDF-treated pregnant women with HBV infection by regulating the has-miR5p/HIF-1alpha axis.
transcription factor target	35306215	hsa-mir-296	Fluorosis, Dental	5p, AMPK/ULK1 may be potential therapeutic targets under the higher fluoride stimulation.
other	35306215	hsa-mir-296	Fluoride Poisoning	Our purpose is to explore the function of miR5p in regulating autophagy of excessive fluoride development.
lncRNA target	35306001	hsa-mir-2208b	Tauopathies	Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy.
lncRNA target	35306001	hsa-mir-4	Tauopathies	Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy.
lncRNA target	35306001	hsa-mir-4805	Tauopathies	Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy.
lncRNA target	35306001	hsa-mir-786	Tauopathies	Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy.
transcription factor target	35305977	hsa-mir-153	Ischemic Stroke	Thus, miR-203a-3p and miR3p confers neuroprotective effects against ischemic stroke via attenuation of apoptosis, oxidative stress and inflammatory pathways through inhibiting SRC-dependent MAPK signaling pathway in vivo and in vitro, suggesting new therapeutic targets for the prevention and treatment of stroke.
transcription factor target	35305977	hsa-mir-203a	Ischemic Stroke	Thus, miR-203a-3p and miR3p confers neuroprotective effects against ischemic stroke via attenuation of apoptosis, oxidative stress and inflammatory pathways through inhibiting SRC-dependent MAPK signaling pathway in vivo and in vitro, suggesting new therapeutic targets for the prevention and treatment of stroke.
exosome	35305974	hsa-mir-181a-2	Diabetes Mellitus, Type 2	In this study, we pointed out that exosomal miR-181a
exosome	35305974	hsa-mir-181a-2	Fibrosis	In this study, we pointed out that exosomal miR-181a3p from CIT-treated hepatocytes induced mitochondrial calcium accumulation and activated HSC subsequently through inhibiting the expression of MICU1, shedding new light on the mechanism underlying liver fibrosis and CIT hepatotoxicity.
circulation_biomarker_diagnosis_up	35305574	hsa-mir-378	Tuberculosis, Pulmonary	Serum miR-378 expression > 1.490 had high sensitivity and specificity in TB diagnosis.
other	35305556	hsa-mir-155	Sepsis	5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic.
other	35305556	hsa-mir-423	Sepsis	5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic.
other	35305556	hsa-mir-15a	Sepsis	By day 7 of gentamicin treatment miR-15a-5p provided good discrimination between AKI and non-AKI (area under curve, 0.828).
other	35305556	hsa-mir-192	Sepsis	5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic.
lncRNA target	35305236	hsa-mir-584	Neuroblastoma	5p and miR-34a-5p, which also offered an underlying targeted therapy for NB treatment.
lncRNA target	35305236	hsa-mir-34a	Neuroblastoma	5p and miR-34a-5p, which also offered an underlying targeted therapy for NB treatment.
lncRNA target	35305106	hsa-mir-27b	Ovarian Neoplasms	MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells.
lncRNA target	35305106	hsa-mir-23a	Ovarian Neoplasms	MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells.
lncRNA target	35305106	hsa-mir-590	Ovarian Neoplasms	MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells.
lncRNA target	35304834	hsa-mir-23b	Cardiomyopathies	CONCLUSIONS: This study supported that silencing Sox2OT inhibited CME-induced MI by eliminating Sox2OT/miR-23b binding and down-regulating the TLR4/NF-kappaB pathway.
circulation_biomarker_diagnosis_ns	35304668	hsa-mir-98	Asthma	5p expression in plasma of asthmatic patients and IL
other	35304514	hsa-mir-206	Breast Neoplasms	MiR-206 is reported to be down-regulated in Luminal-A type of breast cancer.
other	35304180	hsa-mir-462	Walker-Warburg Syndrome	The teleost specific miR-462/miR-731 cluster was strongly induced in POMV infected fish and deemed a potential biomarker of early infection.
other	35304180	hsa-mir-731	Walker-Warburg Syndrome	The teleost specific miR-462/miR-731 cluster was strongly induced in POMV infected fish and deemed a potential biomarker of early infection.
other	35304174	hsa-mir-489	Neuropathic Allodynia	3p/DEK/TET1 transcriptional axis may contribute to neuropathic allodynia.
other	35304162	hsa-mir-34a	Diabetic Retinopathy	In severe NPDR group along with highly increased levels of both miR-146a and miR-21, a marked decrease in miR-34a. In PDR group miR-34a was almost diminished along with very high levels of both miR-146a and miR-21.
circulation_biomarker_prognosis_up	35304162	hsa-mir-21	Diabetic Retinopathy	RESULTS: Serum relative expressions of miR-146a and miR-21 were increased with increased severity of DR.
circulation_biomarker_prognosis_up	35304162	hsa-mir-146a	Diabetic Retinopathy	RESULTS: Serum relative expressions of miR-146a and miR-21 were increased with increased severity of DR.
genetics_knock down_suppress	35304105	hsa-mir-142	Alzheimer Disease	CONCLUSION: These data illustrated that knockdown of RMRP inhibited autophagy and apoptosis via regulating miR-3142/TRIB3 axis in AD, suggesting that inhibition of RMRP maybe a therapeutic strategy for AD.
lncRNA target	35303885	hsa-mir-539	Osteoarthritis	MiR3p may have significant clinical applications for use as a targeted therapy of OA.
genetics_overexpression_promote	35303795	hsa-mir-140	Arthritis, Rheumatoid	Overexpression of SGK1 reversed the inhibition of RASF growth caused by overexpression of miR
genetics_knock down_suppress	35303564	hsa-mir-23a	Reperfusion Injury	Here, we investigated the effects of exosomal miR-23a-3p on gut damage using primary IECs that underwent oxygen-glucose deprivation (OGD) as well as II/R rats. Injection of miR-23a-3p knockdown exosomes aggravated the II/R injury, whereas PF-6260933, a small-molecule inhibitor of MAP4K4, partly reversed the injury.
genetics_overexpression_promote	35303413	hsa-mir-122	Fibrosis	In summary, miR5p overexpression exerted anti-fibrosis effect and inhibited HSC activation by suppressing the c-Abl/HDAC2 pathway.
genetics_knock down_promote	35303365	hsa-mir-363	Prostatic Neoplasms	3p along with Dickkopf 3 (DKK3) were assessed in clinical PCa specimens.
circulation_biomarker_diagnosis_up	35302725	hsa-mir-126	Lung Neoplasms	The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions).
circulation_biomarker_diagnosis_up	35302725	hsa-mir-143	Lung Neoplasms	The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions).
circulation_biomarker_diagnosis_up	35302725	hsa-let-7a	Lung Neoplasms	The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions).
circulation_biomarker_diagnosis_up	35302725	hsa-let-7g	Lung Neoplasms	The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions).
circulation_biomarker_diagnosis_up	35302725	hsa-mir-145	Lung Neoplasms	The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions).
genetics_knock down_promote	35302673	hsa-mir-520a	Carcinoma, Non-Small-Cell Lung	Knockdown of hsa_circ_0017620 inhibited cell proliferation, migration, and invasion in NSCLC cells, which was reversed by downregulating miR-520a-5p or upregulating KRT5 in NSCLC.
circulation_biomarker_diagnosis_up	35302437	hsa-mir-497	Acute Coronary Syndrome	Our study suggests that serum miR
circRNA target	35302432	hsa-mir-423	Stomach Neoplasms	In conclusion, circRNA-0000081 promotes the function of GC through sponging hsa-miR5p to influence PDPK1 expression, which has a promising therapeutic potential for treating patients with GC.
circulation_biomarker_diagnosis_ns	35302299	hsa-mir-21	Sciatica	OBJECTIVES: To explore the relationship between the plasma and local expression of miR-21 with disease severity of lumbar disc herniation (LDH) patients with sciatic pain. CONCLUSIONS: Increased local miR-21 expressions are linked with clinical severity of LDH in patients with sciatic pain.
other	35302183	hsa-mir-25	Leukemia, Myeloid, Acute	SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-α upregulation in HQ-treated U937 cells.
transcription factor target	35302171	hsa-mir-33a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	In conclusion, it was demonstrated that TRIB2 regulates miR33a5p to reverse IM resistance in CML, which may help identify novel targets and therapeutic strategies for the clinical treatment of IM resistance.
other	35301863	hsa-mir-124	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-21	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-34a	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-25	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-1	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-9	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-29b	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-485	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
other	35301863	hsa-mir-23a	Atrial Fibrillation	A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485.
lncRNA target	35301686	hsa-mir-1179	Carcinoma, Non-Small-Cell Lung	Mechanistically, circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge miR-375 and miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis.
lncRNA target	35301686	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	Mechanistically, circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge miR-375 and miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis.
genetics_knock down_promote	35301291	hsa-mir-495	Nasopharyngeal Carcinoma	miR-495 knockdown enhanced the expression of c-Myc, Cyclin D1, and survivin and accelerated NPC cell proliferation, migration, invasion, and EMT through targeting MET and activating the MET-eIF4G1 axis.
circulation_biomarker_diagnosis_up	35301154	hsa-mir-193b	Pre-Eclampsia	RESULTS: LncRNA MIR193BHG was upregulated in the serum of PE patients, and MIR193BHG expression in mPE patients was lower than that in sPE patients.
circulation_biomarker_diagnosis_ns	35301154	hsa-mir-345	Pre-Eclampsia	3p was poorly expressed and SASH was highly expressed in serum of PE patients.
genetics_knock down_suppress	35300972	hsa-mir-16	Vertigo	Furthermore, circ_0000831, AdipoR2, or PPARgamma overexpression or miR
genetics_knock down_suppress	35300972	hsa-mir-16	Brain Ischemia	Furthermore, circ_0000831, AdipoR2, or PPARgamma overexpression or miR
circulation_biomarker_diagnosis_ns	35300960	hsa-mir-4793	Stomach Neoplasms	Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR
circulation_biomarker_diagnosis_ns	35300960	hsa-mir-1273g	Stomach Neoplasms	Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR
circulation_biomarker_diagnosis_ns	35300960	hsa-mir-619	Stomach Neoplasms	Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR
circulation_biomarker_diagnosis_up	35300771	hsa-mir-29b	Myocarditis	Results Compared with healthy controls,the FM patients had up-regulated expression levels of miR-29b(t=18.925,P<0.001)and miR-125b(t=5.981,P=0.029)in the plasma.After treatment,the expression levels of miR-29b(t=12.943,P<0.001)and miR-125b(t=14.016,P<0.001)were significantly down-regulated.KEGG pathway enrichment showed that the targets of miR-29b were involved in inflammatory response and apoptosis pathways.The results of cell proliferation and apoptosis assay demonstrated the transfection of miR-29b mimic had a more significant inducing effect on cardiomyocyte apoptosis than that of miR-125b mimic(chi (2)=6.168,P=0.047),whereas there was no significant difference in the inhibition of cell proliferation between the two groups(chi(2)=1.452,P=0.417).The expression levels of miR-29b and miR-125b were negatively correlated with left ventricular ejection fraction(r=-0.67,P=0.071;r=-0.49,P=0.003).They were positively correlated with cardiac troponin I level(r=0.61,P=0.019;r=0.52,P=0.016),interferon beta level(r=0.42,P=0.014;r=0.36,P=0.021),and myocardial edema area(r=0.86,P=0.005;r=0.73,P=0.013).The ROC curve analysis demonstrated that miR-29b had higher sensitivity for the diagnosis of FM(93.6% vs.89.2%;t=0.896,P=0.795)and specificity(72.4% vs.59.6%;t=9.478,P=0.002)than miR-125b. Conclusion The circulating miR-29b may be a potential biomarker for the diagnosis of FM.
circulation_biomarker_diagnosis_up	35300771	hsa-mir-125b	Myocarditis	Results Compared with healthy controls,the FM patients had up-regulated expression levels of miR-29b(t=18.925,P<0.001)and miR-125b(t=5.981,P=0.029)in the plasma.After treatment,the expression levels of miR-29b(t=12.943,P<0.001)and miR-125b(t=14.016,P<0.001)were significantly down-regulated.KEGG pathway enrichment showed that the targets of miR-29b were involved in inflammatory response and apoptosis pathways.The results of cell proliferation and apoptosis assay demonstrated the transfection of miR-29b mimic had a more significant inducing effect on cardiomyocyte apoptosis than that of miR-125b mimic(chi (2)=6.168,P=0.047),whereas there was no significant difference in the inhibition of cell proliferation between the two groups(chi(2)=1.452,P=0.417).The expression levels of miR-29b and miR-125b were negatively correlated with left ventricular ejection fraction(r=-0.67,P=0.071;r=-0.49,P=0.003).They were positively correlated with cardiac troponin I level(r=0.61,P=0.019;r=0.52,P=0.016),interferon beta level(r=0.42,P=0.014;r=0.36,P=0.021),and myocardial edema area(r=0.86,P=0.005;r=0.73,P=0.013).The ROC curve analysis demonstrated that miR-29b had higher sensitivity for the diagnosis of FM(93.6% vs.89.2%;t=0.896,P=0.795)and specificity(72.4% vs.59.6%;t=9.478,P=0.002)than miR-125b.
transcription factor target	35300770	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	Conclusion Puerarin could inhibit the proliferation,invasion,and migration of non-small cell lung cancer cells by up-regulating miR-490 and down-regulating DTL.
transcription factor target	35300572	hsa-mir-7	Urinary Bladder Neoplasms	5p as a cancer suppressor gene in BCa and provide new opportunities for the treatment of BCa.
genetics_overexpression_suppress	35300565	hsa-mir-124	Carcinoma, Hepatocellular	Overexpression of miR
genetics_overexpression_suppress	35300558	hsa-mir-124	Nasopharyngeal Carcinoma	3p overexpression-induced NPC cell radiosensitivity.
exosome	35300408	hsa-mir-483	Multiple Myeloma	In summary, our study indicated that MM-MSCs promote MM malignant progression via the release of exosomes and regulation of miR
exosome	35300348	hsa-mir-132	Hepatoblastoma	CONCLUSION: HB-derived exosomal lncRNA NEAT1 induced BMSCs differentiation into tumor-supporting myofibroblasts via modulating miR-132/MMP9 axis, which provided a new target for HB treatment.
genetics_knock down_suppress	35300347	hsa-mir-194	Thyroid Cancer, Papillary	Moreover, miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells.
lncRNA target	35300139	hsa-mir-30	Myocardial Infarction	The experimentally constructed miRNA-mRNA regulatory network found that hsa-miR-190b targets to inhibit FGF2, while hsa-miR3p targets to regulate MMP2, which may mediate Integrins in angiogenesis, Angiopoietin receptor Tie2-mediated signaling pathway to induce AMI pathogenesis, providing strong data support and a research direction for the prevention and treatment of AMI.
lncRNA target	35300139	hsa-mir-190b	Myocardial Infarction	The experimentally constructed miRNA-mRNA regulatory network found that hsa-miR-190b targets to inhibit FGF2, while hsa-miR3p targets to regulate MMP2, which may mediate Integrins in angiogenesis, Angiopoietin receptor Tie2-mediated signaling pathway to induce AMI pathogenesis, providing strong data support and a research direction for the prevention and treatment of AMI.
lncRNA target	35300071	hsa-mir-142	Osteoarthritis	5p to inhibit chondrocyte autophagy and promote chondrocyte proliferation in osteoarthritis.
genetics_knock down_promote	35300063	hsa-mir-760	Carcinoma, Non-Small-Cell Lung	CONCLUSION: SLC9A3-AS1 was upregulated in NSCLC, and SLC9A3-AS1 knockdown hindered NSCLC progression through targeting miR-760, suggesting that it may prove to be a novel biomarker and therapeutic target for NSCLC.
genetics_overexpression_promote	35300057	hsa-mir-183	Prostatic Neoplasms	5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer.
genetics_overexpression_promote	35300057	hsa-mir-20b	Prostatic Neoplasms	5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer.
genetics_overexpression_promote	35300057	hsa-mir-96	Prostatic Neoplasms	5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer.
transcription factor target	35299961	hsa-mir-200c	Non-alcoholic Fatty Liver Disease	The findings suggested that miR-200c-3p should be further explored as a potential target for the treatments of NAFLD.
other	35299889	hsa-mir-218	Glioma	Furthermore, we shed light on the underlying mechanism of PTBP1 by constructing a miRTCF3-PTBP1 transcriptional network in glioma.
genetics_knock down_promote	35298438	hsa-mir-92a	Encephalomyelitis, Autoimmune, Experimental	miR-92a was elevated in experimental autoimmune encephalomyelitis (EAE), and its loss attenuated EAE.
lncRNA target	35298438	hsa-mir-92a	Autoimmune Diseases of the Nervous System	Here, we report a major disease-promoting role for microRNA-92a (miR-92a) in CNS autoimmunity. Together, our results demonstrate that miR-92a drives CNS autoimmunity by sustaining the Treg/Th17 imbalance and implicate miR-92a as a potential therapeutic target for MS.
genetics_overexpression_promote	35297352	hsa-mir-221	Ovarian Neoplasms	CONCLUSION: Collectively, overexpression of LINC00936 suppressed the development of ovarian cancer by competitively binding to miR
lncRNA target	35297315	hsa-mir-940	Osteosarcoma	Overall, these findings indicated that miR-940/ZDHHC19 axis played a significant role in OS progression and might be considered as a novel target for OS treatment.Abbreviations: OS, osteosarcoma; miRNAs, microRNAs; 3'-UTR, 3'- untranslated region; TARGET, Therapeutically Applicable Research To Generate Effective Treatments; qRT-PCR, quantitative real-time PCR; IHC, Immunohistochemistry; GSVA, Gene Set Variation Analysis; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes.
lncRNA target	35297212	hsa-mir-940	Esophageal Squamous Cell Carcinoma	CONCLUSION: Circ_0003340 downregulation mitigated esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis.
genetics_GWAS	35296964	hsa-mir-211	Breast Neoplasms	Our findings revealed that TUSC7 functions as a tumor suppressor in BC potentially via miR-211/Nurr1, which might be disturbed by the cer-SNP rs2615499.
other	35296567	hsa-mir-9	Glomerulonephritis, Membranous	5p may become new non-invasive biomarkers of IMN.
genetics_overexpression_promote	35296211	hsa-mir-637	Neurodegenerative Diseases	This study investigated the mechanism of miR-637 inhibiting osteogenic differentiation of human CESC by regulating WNT5A.Methods: The degenerative CEP (N = 10) and non-degenerative CEP (N = 6) were obtained from patients undergoing disk fusion surgery. After simultaneous overexpression of miR-637/WNT5A, the effect of miR-637 on osteogenic differentiation of CESCs was assessed.Results: miR-637 was down-expressed in degenerative CESCs (D-CESCs), and miR-637 overexpression inhibited the osteogenic differentiation of D-CESCs, while inhibition of miR-637 promoted the osteogenic differentiation ability of D-CESCs.
lncRNA target	35296211	hsa-mir-637	Porphyria, Erythropoietic	This study investigated the mechanism of miR-637 inhibiting osteogenic differentiation of human CESC by regulating WNT5A.Methods: The degenerative CEP (N = 10) and non-degenerative CEP (N = 6) were obtained from patients undergoing disk fusion surgery.
genetics_knock down_suppress	35296158	hsa-mir-210	Myocardial Infarction	phosphate dehydrogenase is a novel target of microRNA-210 in the heart, and loss-of-function and gain-of-function experiments revealed that glycerol
transcription factor target	35295962	hsa-mir-129-1	Triple Negative Breast Neoplasms	1-3p was illustrated to serve as a tumor repressor via targeting GRIN2D in TNBC cells and highlight that the restoration of miR
lncRNA target	35295711	hsa-mir-25	Carcinoma, Renal Cell	In summary, circPSD3 inhibits tumor metastasis by repressing the miR3p/FBXW7-EMT axis and might be developed as a potential diagnostic and therapeutic target for ccRCC.
exosome	35295267	hsa-mir-210	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-133a	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-15a	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-210	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-155	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-18a	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-19a	Myocardial Ischemia	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-18a	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-155	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-133a	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-19a	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
exosome	35295267	hsa-mir-15a	Diabetes Mellitus, Type 2	Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR
transcription factor target	35295173	hsa-mir-27a	Intervertebral Disc Degeneration	CONCLUSION: MiR-27a-3p may target RASSF5 and enhance cell proliferation and imped cell apoptosis of the nucleus pulposus cells via the MST1/LATS1 and RAS/RAC1 pathway, lessening the degeneration of intervertebral discs.
lncRNA target	35295003	hsa-mir-18a	Prostatic Neoplasms	Moreover, mechanistic analysis revealed a novel regulatory network of GAS5/miR-18a-5p/serine/threonine kinase 4 (STK4) that inhibits epithelial-to-mesenchymal transition (EMT) and enhances tumor stem cell-like-mediated sensitivity to paclitaxel in PCa.
other	35294699	hsa-mir-22	Triple Negative Breast Neoplasms	PURPOSE: Downregulation of miRNA-22 in triple-negative breast cancer (TNBC) is associated with upregulation of eukaryotic elongation 2 factor kinase (eEF2K) protein, which regulates tumor growth, chemoresistance, and tumor immunosurveillance. More importantly, drug synergy was identified between miRNA-22 and standard-of-care drugs against TNBC, providing a basis for rational therapeutic combinations for improved response CONCLUSIONS: The present study highlights the translational potential of miRNA-22 nanotherapy for TNBC in combination with standard-of-care drugs.
lncRNA target	35294601	hsa-mir-155	Depression	Collectively, these findings suggested that SM exerted antidepressant actions by targeting the miRNA
lncRNA target	35294329	hsa-mir-107	Squamous Cell Carcinoma of Head and Neck	The above findings revealed that miR-107 could suppress FaDu cell proliferation, migration, invasion and induced apoptosis by targeting NOB1 through the PI3K/Akt pathway, suggesting that miR-107/NOB1 axis may exert a key role in FaDu HSCC development.
exosome	35294195	hsa-mir-155	Diabetes Mellitus	inhibitor-loaded MSC-derived exosomes in diabetic wound healing and opened the doors for encapsulating miRNAs along with antibiotics within the MSC-derived exosomes toward improved management of chronic, nonhealing diabetic wounds.
genetics_knock down_suppress	35293807	hsa-mir-30	psoriasis 1	CONCLUSION: Circ_0060531 knockdown assuaged IL
lncRNA target	35293774	hsa-mir-10a	Porcine Reproductive and Respiratory Syndrome	Our previous work has indicated that the expression level of miR-10a increased in porcine alveolar macrophages (PAMs) during porcine reproductive and respiratory syndrome virus (PRRSV) infection and further inhibited viral replication through downregulates the expression of host molecule signal-recognition particle 14 (SRP14) protein.
transcription factor target	35293661	hsa-mir-146a	Prostatic Neoplasms	A dual luciferase reporter gene assay identified the regulatory relationship between APIP and miR-146a-3p in prostate cancer, suggesting that APIP is a direct target of miR-146a-3p. miR-146a-3p reduced cell proliferation and migration in prostate cancer.
genetics_GWAS	35293603	hsa-mir-423	Diabetes Mellitus, Type 2	In the present study, the association of the single nucleotide polymorphisms (SNPs) in the GCK, MIR196A2 and MIR423 genes with susceptibility to T2DM in patients from two regions of Saudi Arabia were examined, using the tetraprimer amplification refractory mutation system.
therapeutic target	35293593	hsa-mir-218	Osteosarcoma	miR-218 targets multiple oncogenes and is a therapeutic target for osteosarcoma.
transcription factor target	35293311	hsa-mir-122	Sepsis	Mannan binding lectin serine peptidase 1(MASP1) was a direct target gene of miR5p, and levels of MASP1, C3, and C4 were all significantly lower in the sepsis with disseminated intravascular coagulopathy (DIC) group than in the sepsis without DIC group.
other	35293311	hsa-mir-122	Blood Coagulation Disorders	MiR5p is a diagnostic and prognostic biomarker of sepsis and is correlated with coagulation abnormalities in sepsis.
transcription factor target	35293311	hsa-mir-122	Disseminated Intravascular Coagulation	Mannan binding lectin serine peptidase 1(MASP1) was a direct target gene of miR5p, and levels of MASP1, C3, and C4 were all significantly lower in the sepsis with disseminated intravascular coagulopathy (DIC) group than in the sepsis without DIC group.
genetics_knock down_suppress	35293286	hsa-mir-455	Carcinoma, Hepatocellular	In conclusion, HCC cell proliferation, invasion, and migration were restrained by knockdown of HUMT, which was related to the miR
transcription factor target	35293283	hsa-mir-26b	Urinary Bladder Neoplasms	MI significantly suppressed the proliferation, colony formation, invasion, and migration and induced apoptosis of human bladder cancer cells, and MI significantly increased miR-26b expression. Overall, MI showed a potent anti-tumor effect against bladder cancer partially via modulating the miR-26b/Nox4 axis.
circRNA target	35293280	hsa-mir-585	Carcinoma, Non-Small-Cell Lung	Our study demonstrated that silencing of circ_0002360 enhanced the Taxol sensitivity and suppressed the malignant behaviors of Taxol-resistant NSCLC cells by miR
other	35293246	hsa-mir-26a	Obesity	Moreover, a different expression of miR-26a and miR-338 in the obese group was found.
other	35293246	hsa-mir-338	Obesity	Moreover, a different expression of miR-26a and miR-338 in the obese group was found.
genetics_knock down_promote	35293097	hsa-mir-106a	Nasopharyngeal Carcinoma	Exosomal miR-106a-5p could enter NPC cells, and its overexpression promoted the proliferation, migration, invasion, and metastasis of NPC cells, which were suppressed by knockdown of exosomal miR-106a-5p.
genetics_knock down_suppress	35293026	hsa-mir-411	Carcinoma, Hepatocellular	MATERIAL AND METHODS: The expression of SLC16A1-AS1 and miR-411 was examined in clinical HCC tissues. In addition, SLC16A1-AS1 knockdown and miR-411 overexpression significantly stagnated the progression of HCC cells.
circulation_biomarker_prognosis_up	35292840	hsa-mir-370	Colorectal Neoplasms	CONCLUSION: Our data suggest that miR-370 with its clear expression in plasma samples may be a potential diagnostic marker to determine the severity of the disease in patients at a later stage of colorectal cancer.
other	35292776	hsa-mir-124	Spinal Cord Injuries	There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury.
other	35292776	hsa-mir-544a	Spinal Cord Injuries	There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury.
other	35292776	hsa-mir-124	Ischemic Stroke	There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury.
other	35292776	hsa-mir-544a	Ischemic Stroke	There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury.
genetics_overexpression_promote	35292240	hsa-mir-335	Osteoporosis-pseudoglioma syndrome	In vivo experiments also found that overexpression of miR
other	35292022	hsa-mir-199a	Small Cell Lung Carcinoma	CONCLUSIONS: The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance.
lncRNA target	35291921	hsa-mir-26b	Carcinoma, Hepatocellular	In conclusion, our results demonstrated that HAGLROS contributed to the malignant progression of HCC via serving as a sponge for miR-26b-5p to facilitate KPNA2 expression and inactivate p53 signaling. Targeting HAGLROS/miR-26b-5p/KPNA2 axis might be an alternative therapeutic strategy for HCC patients.
exosome	35291915	hsa-mir-93	Norrie disease	In summary, our study demonstrated that M2 macrophage-secreted exosomes attenuated LPS-induced podocyte apoptosis by regulating the miR5p/TLR4 axis, which provides a new perspective for the treatment of patients with DN.
genetics_knock down_suppress	35291714	hsa-mir-338	Acute Lung Injury	Overall, circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR3p/DUSP16 axis.
lncRNA target	35291619	hsa-mir-124a	Arthritis, Rheumatoid	Targeting circHIPK3 and microRNA-124a, and their downstream adaptor molecules, poses a new challenge for RA therapy.
circulation_biomarker_diagnosis_up	35291612	hsa-mir-374	Colorectal Neoplasms	This study investigated the effect of radiotherapy on miR-374 expression, and APC and GSK-3beta, two of its target genes, in the WNT pathway, in peripheral blood samples from radiotherapy-treated colorectal cancer (CRC) patients. RESULTS: Quantitative RT-PCR revealed significant down-regulation of miR-374 (0.63-fold) and up-regulation of APC (1.12-fold) and GSK-3beta (1.22-fold) in CRC patients after five weeks of radiotherapy.
circulation_biomarker_diagnosis_up	35290882	hsa-mir-155	Lung Neoplasms	For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively.
circulation_biomarker_diagnosis_up	35290882	hsa-mir-21	Lung Neoplasms	For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively.
circulation_biomarker_diagnosis_up	35290882	hsa-mir-205	Lung Neoplasms	For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively.
circulation_biomarker_diagnosis_up	35290882	hsa-let-7b	Lung Neoplasms	For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively.
lncRNA target	35290861	hsa-mir-124	Canine Mammary Carcinoma	In conclusion, miR-124 regulates CMC tumor growth and EMT by targeting CDH2, maybe a potential therapeutic strategy against CMC.
transcription factor target	35289984	hsa-mir-221	Obesity, Abdominal	CONCLUSIONS: Bioinformatic analysis evidenced that miR3p participates in several obesity-related pathways, and more interestingly, this miRNA targets several candidate genes to childhood obesity according to DisGeNet database.
exosome	35289974	hsa-mir-155	Diabetic Nephropathies	AIM: Evaluate the expression of exomiRs-126, -146, and -155 in urinary exosomes of patients with T2DM and diabetic kidney disease to establish a predictive classification model with exomiRs and clinical variables in order to determine their contribution to DKD.
other	35289974	hsa-mir-126	Diabetic Nephropathies	In addition, T2DM patients with albuminuria presented a significant increase in miR-126 contrasted to controls and patients without albuminuria.
exosome	35289974	hsa-mir-146	Diabetic Nephropathies	AIM: Evaluate the expression of exomiRs-126, -146, and -155 in urinary exosomes of patients with T2DM and diabetic kidney disease to establish a predictive classification model with exomiRs and clinical variables in order to determine their contribution to DKD.
other	35289769	hsa-mir-182	Depression	miR-182 was poorly expressed in patients with CHD. Our results demonstrated that HDAC1 repressed miR-182 and activated the TGF-beta/Smad pathway to promote CHD.
genetics_knock down_promote	35289739	hsa-mir-193a	Lung Neoplasms	Circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR
genetics_knock down_promote	35289739	hsa-mir-98	Lung Neoplasms	Circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR
other	35289275	hsa-mir-134	Carcinoma, Renal Cell	VEGFA, FLT1, EGLN3, DLL4, and miR5p may be novel biomarkers for RCC.
other	35289243	hsa-mir-1290	Esophageal Squamous Cell Carcinoma	As a result, circCDR1 was low-expressed in ESCC tissues and cells, while miR-1290 was high-expressed. Collectively, circCDR1 sponged miR-1290 to regulate the progression of ESCC both in vitro and in vivo.
genetics_overexpression_suppress	35288979	hsa-mir-197	Colorectal Neoplasms	Similarly, overexpression of PFKFB3 can regulate CRC cell behavior and 5-FU resistance caused by miR
exosome	35288625	hsa-mir-143	Polycystic Ovary Syndrome	3p-containing exosomes derived from PCOS follicular fluid promoted granulosa cell apoptosis by targeting BMPR1A and blocking the Smad1/5/8 signaling pathway.
circRNA target	35288538	hsa-mir-766	Pancreatic Carcinoma	In conclusion, our results demonstrated that circATG7 accelerates PC progression via miR5p/ATG7 and that HUR/ATG7 depends on autophagic flux.
circulation_biomarker_diagnosis_down	35288364	hsa-mir-210	Peripheral Arterial Disease	Previous studies have demonstrated that circulating microRNA (miR)-210 levels are elevated in peripheral artery disease (PAD) patients.
exosome	35288170	hsa-mir-127	Choriocarcinoma	This research aimed to study the effects of miR3p-enriched EVs (EV-miR3p) on CC and underlying mechanisms. RESULTS: The expression of miR3p was downregulated, while that of ITGA6 was upregulated in CC cell lines. EV-miR3p could inhibit the proliferation, invasion, migration, and promote the apoptosis of CC cells. We observed that EV-miR3p suppressed EMT of CC cells by targeting ITGA6. CONCLUSION: These results indicate that EV-miR3p from hUCMSCs exhibits anti-tumor effects by targeting ITGA6, which may be used as a novel therapeutic strategy for CC treatment.
genetics_overexpression_promote	35287604	hsa-mir-335	Carcinoma, Hepatocellular	5p overexpression partly counteracted the effect of circ_0064288 overexpression on HCC cells.
other	35287556	hsa-let-7a	Stomach Neoplasms	In conclusion, TTTY15 promotes GC progression, by regulating the let-7a-5p/Wnt1 axis to activate the Wnt/beta-catenin pathway.
genetics_overexpression_suppress	35287547	hsa-mir-3200	Glioma	3p, and CAMK2A overexpression reversed the anticancer roles of miR
genetics_knock down_promote	35287543	hsa-mir-1296	Carcinoma, Non-Small-Cell Lung	Furthermore, SIX1 overexpression counteracted the inhibiting impact of miR
genetics_overexpression_promote	35287147	hsa-mir-20a	Hypoxia-Ischemia, Brain	Besides, overexpressed MAT2B reversed the effect of overexpressed miR-20a-5p on the levels of MAT2B, Bcl-2 and Bax, brain tissue damage, as well as the learning and memory abilities in rats with HIBD.
circulation_biomarker_diagnosis_ns	35286944	hsa-mir-155	Breast Neoplasms	Based on this consistency, two circulating miRNA markers for breast cancer (miR-21 and miR-155) were used as the SERS diagnostic target.
circulation_biomarker_diagnosis_ns	35286944	hsa-mir-21	Breast Neoplasms	Based on this consistency, two circulating miRNA markers for breast cancer (miR-21 and miR-155) were used as the SERS diagnostic target.
transcription factor target	35286917	hsa-mir-34a	Nephritis, Interstitial	miR-34a mimic inhibits Foxp3 expression via targeting 3' untranslated region (3'UTR) whereas its inhibitor promotes Foxp3 expression in vitro.
other	35286916	hsa-mir-149	Aortic Aneurysm, Abdominal	Then, we constructed ceRNA network of circRNA-miRNA-mRNA (IL-6/CCL2/NF-kappaB) in AAA and found that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR5p in macrophages.
circulation_biomarker_diagnosis_ns	35286868	hsa-mir-124	Acute Kidney Injury	We also found that in the serum of SA-AKI patients, LPCAT3 activity was increased, and miR
circulation_biomarker_diagnosis_ns	35286626	hsa-mir-101	Atherosclerosis	In summary, these data indicate that CTRP15 inhibits the development of atherosclerosis by enhancing RCT efficiency and increasing plasma HDL-C levels via the T-cadherin/miR3p/ABCA1 pathway.
genetics_overexpression_promote	35286539	hsa-mir-181a	Osteoarthritis	OPN overexpression exerted opposite effects on OA chondrocytes and significantly attenuated the roles of miR-181a-5p overexpression in OA chondrocytes.
transcription factor target	35286466	hsa-mir-625	Amyotrophic Lateral Sclerosis	We also assayed the expression profile of these miRNAs in the cerebrospinal fluid (CSF) of familial (fALS) and sporadic patients (sALS) and we identified a significant dysregulation of miR-34a-3p and miR3p levels in ALS compared to controls.
transcription factor target	35286466	hsa-mir-34a	Amyotrophic Lateral Sclerosis	We also assayed the expression profile of these miRNAs in the cerebrospinal fluid (CSF) of familial (fALS) and sporadic patients (sALS) and we identified a significant dysregulation of miR-34a-3p and miR3p levels in ALS compared to controls.
genetics_overexpression_promote	35286011	hsa-mir-455	Carcinoma, Hepatocellular	And overexpression of miR
circRNA target	35285770	hsa-mir-1	Diabetic Nephropathies	CONCLUSION: In summary, our data showed that hsa_circ_0037128 could promote HG-induced podocytes injury via regulating miR5p/KLF9 axis, showing that hsa_circ_0037128 might be a target for DN treatment.
transcription factor target	35285580	hsa-mir-7114	Colorectal Neoplasms	5p pairs play an important role in early CRC development, and may help identify potential molecular targets for early detection of CRC.
transcription factor target	35285580	hsa-mir-6780	Colorectal Neoplasms	5p pairs play an important role in early CRC development, and may help identify potential molecular targets for early detection of CRC.
exosome	35285412	hsa-mir-106a	Lymphoma	Lymphoma cell-derived extracellular vesicles inhibit autophagy and apoptosis to promote lymphoma cell growth via the microRNA-106a/Beclin1 axis.
other	35285410	hsa-mir-1294	Carcinoma, Renal Cell	Furthermore, we identified a novel circZKSCAN1/miR-1294/PIM1 axis was identified in RCC progression, showing that the expression of circZKSCAN1 expression in RCC cells was transcriptionally regulated by Kruppel-like factor 2.
lncRNA target	35285389	hsa-mir-582	Osteoporosis	3p may be a therapeutic target of osteoporosis treatment.
other	35285386	hsa-mir-106a	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-20b	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-15b	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-20a	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-15a	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-106a	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-16	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-15a	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-20a	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-20b	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-195	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-92a	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-92a	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-15b	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-16	Hypertension	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
other	35285386	hsa-mir-195	Alzheimer Disease	5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension.
genetics_knock down_promote	35285372	hsa-mir-1287	Retinoblastoma	5p, thus acting as a contributor to RB carcinogenesis.HighlightsCirc_0075804 is overexpressed in RB.Circ_0075804 knockdown inhibits RB cell malignant phenotypes and tumor growth in vivo.Circ_0075804 regulates RB cell behaviors by targeting miR
genetics_knock down_promote	35284960	hsa-mir-876	Triple Negative Breast Neoplasms	3p was confirmed as a target of circ_0062558, and circ_0062558 knockdown repressed TNBC cell malignant behaviors by increasing miR
transcription factor target	35284668	hsa-mir-20a	Colorectal Neoplasms	In vitro assays demonstrated that elevated miR-20a up-regulated FA synthesis enzymes via Wnt/beta-catenin signaling, and finally promoted proliferative and migration of metabolic CRC cells.
lncRNA target	35284630	hsa-mir-548i	Carcinoma, Non-Small-Cell Lung	Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment.
lncRNA target	35284630	hsa-mir-1184	Carcinoma, Non-Small-Cell Lung	Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment.
circulation_biomarker_diagnosis_up	35284624	hsa-mir-205	Nasopharyngeal Carcinoma	We found that up-regulated serum exosomal miR
lncRNA target	35284500	hsa-mir-762	Myocardial Infarction	In addition, bioinformatics analysis, luciferase activity, and western blot assay proved UCP2 was a direct target gene of microRNA-762, a up-regulated microRNA after MI. In conclusion, UCP2 plays a protective role after MI and the mechanism is involved in microRNA-762 upstream and DRP1-dependent mitochondrial fission downstream.
other	35284413	hsa-mir-212	Cartilage Diseases	Excessive chondrocyte degeneration and inflammation are the pathological features of osteoarthritis (OA), and altered miR5p may contribute to meniscus and cartilage degeneration.
other	35284413	hsa-mir-212	Inflammation	Excessive chondrocyte degeneration and inflammation are the pathological features of osteoarthritis (OA), and altered miR5p may contribute to meniscus and cartilage degeneration.
transcription factor target	35284238	hsa-mir-203a	Pericardial Effusion	Embryos treated with the miR-203a inhibitor and Phe exhibited a reduced heart rate by 48 h post fertilization (hpf), with an increased incidence of developmental deformities (including pericardial edema, altered eye development, and spinal deformities) and reduced caudal fin length by 72 hpf.
transcription factor target	35284238	hsa-mir-203a	Spinal Diseases	Embryos treated with the miR-203a inhibitor and Phe exhibited a reduced heart rate by 48 h post fertilization (hpf), with an increased incidence of developmental deformities (including pericardial edema, altered eye development, and spinal deformities) and reduced caudal fin length by 72 hpf.
other	35284238	hsa-mir-203a	Cardiovascular Diseases	Early studies evaluating the effects of oil on developmental toxicity in early life stages of fish showed that reductions in expression of miR-203a were associated with enhanced expression of downstream mRNAs that predicted altered eye development, cardiovascular disease, and improper fin development.
target gene	35284123	hsa-mir-448	Carcinoma, Hepatocellular	MiR-448 suppresses cell proliferation and glycolysis of hepatocellular carcinoma through inhibiting IGF-1R expression.
lncRNA target	35284121	hsa-mir-17	Colorectal Neoplasms	Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR
lncRNA target	35284121	hsa-mir-193a	Colorectal Neoplasms	Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR
lncRNA target	35284121	hsa-mir-92a	Colorectal Neoplasms	Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR
lncRNA target	35284121	hsa-mir-485	Colorectal Neoplasms	Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR
other	35283744	hsa-mir-128	Nondisjunction, Genetic	By analogy, reducing miR-128 could enhance the capacity to learn to speak in patients with non-verbal ASD.
transcription factor target	35283744	hsa-mir-128	Heart Septal Defects, Atrial	By analogy, reducing miR-128 could enhance the capacity to learn to speak in patients with non-verbal ASD. To our knowledge, this study is the first to directly link miR-128 to learned vocal communication and provides support for miR-128 as a potential therapeutic target for ASD.
genetics_overexpression_promote	35283536	hsa-mir-1	psoriasis 1	CONCLUSIONS: Our findings indicate that overexpression of miR-31 causes upregulation of STAT3, which further brings about upregulation of p53, and eventually leads to serious psoriasis skin lesion.
lncRNA target	35283358	hsa-mir-181a	Inflammation	Thus, we evaluated the effects of miR-181a-5p on inflammation in PC12 cells and the underlying mechanism in play. Upregulation of miR-181a-5p (via transfection) inhibited inflammation of, and HMGB1 expression by, LPS-induced PC12 cells.
transcription factor target	35283358	hsa-mir-181a	Spinal Cord Injuries	CONCLUSIONS: miR-181a-5p attenuated the inflammatory response of LPS-induced PC12 cells by directly inhibiting HMGB1; thus, miR-181a-5p may serve as a therapeutic target in SCI.
genetics_knock down_promote	35283197	hsa-mir-16	Breast Neoplasms	Knockdown of EPHA1 or inhibition of NF-kappaB signaling reversed the effects of down-regulated miR
other	35283179	hsa-mir-484	Mental Disorders	3p).
other	35283179	hsa-mir-106b	Mental Disorders	3p).
other	35283179	hsa-mir-33a	Mental Disorders	3p).
other	35283179	hsa-mir-24	Mental Disorders	3p).
other	35283179	hsa-mir-25	Mental Disorders	3p).
other	35282774	hsa-mir-150	Osteoporosis-pseudoglioma syndrome	Compared with controls, the expression of MIAT was significantly increased, whereas that of miR5p was markedly decreased in patients with OP.
lncRNA target	35282764	hsa-mir-874	Stomach Neoplasms	3p downregulation on GDPD5 expression, viability, migration and invasion of DDP-resistant GC cells.
lncRNA target	35282648	hsa-mir-423	Essential Hypertension	CONCLUSION: FENDRR played an energetic role in EH and contributed to HUVECs dysfunction by restricting cell proliferation, suppressing cell migration, and accelerating cell apoptosis by manipulating the miR
other	35282644	hsa-mir-22	Carcinoma, Hepatocellular	3p were identified as the most promising RRM1 upstream ncRNA-related pathways in HCC.
other	35282644	hsa-mir-4435-2	Carcinoma, Hepatocellular	3p were identified as the most promising RRM1 upstream ncRNA-related pathways in HCC.
genetics_GWAS	35282462	hsa-mir-21	Thyroid Cancer, Papillary	5p) were substantially overexpressed in the hobnail variant.
genetics_GWAS	35282462	hsa-mir-146b	Thyroid Cancer, Papillary	5p) were substantially overexpressed in the hobnail variant.
other	35282268	hsa-mir-34c	Crohn Disease	CONCLUSION: By constructing a ceRNA network with lncRNA-miRNA-mRNA, PCR verification, and KEGG analysis, we revealed that LOC102550026/miRNA-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways might regulate the intestinal immune-inflammatory response, and HPM may regulate the lncRNA LOC102550026/miR-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways, thus improving intestinal inflammation in CD.
transcription factor target	35282137	hsa-mir-26a	Fractures, Bone	Therefore, we propose that targeting miR-26a may be a novel therapeutic method for bone regeneration and treating fractures.
lncRNA target	35282101	hsa-mir-100	Uterine Cervical Neoplasms	3p is an inhibiting factor and miR
lncRNA target	35282101	hsa-mir-142	Uterine Cervical Neoplasms	3p is an inhibiting factor and miR
lncRNA target	35282018	hsa-mir-335	Mucocutaneous Lymph Node Syndrome	CONCLUSIONS: Together, these results indicated that lncRNA Slco4a1 could regulate the progression of HUVECs in KD by targeting the miR5p/POU5F1 axis, providing new insights for KD treatment.
genetics_overexpression_suppress	35281946	hsa-mir-448	Glioblastoma	Furthermore, overexpression of ROCK1 abolished the antitumor effect of miR-448 in GBM.
lncRNA target	35281864	hsa-mir-497	Glioblastoma	5p-RSPO2 axis controls Wnt/beta-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings.
other	35281863	hsa-mir-27b	Stomach Neoplasms	However, down-regulated miR-27b-3p could reverse the effects of weakenTP73-AS1 on the progression of GC. Conclusion: TP73-AS1 promoted GC proliferation, migration, and invasion by sponging miR-27b-3p to regulate TMED5.
target gene	35281858	hsa-mir-137	Lung Neoplasms	LncRNA LASTR promote lung cancer progression through the miR-137/TGFA/PI3K/AKT axis through integration analysis.
target gene	35281849	hsa-mir-152	Ovarian Neoplasms	CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.
genetics_GWAS	35281840	hsa-mir-27a	Esophageal Neoplasms	Furthermore, many biological functions and pathways related to immunity and ferroptosis were enriched in the high-risk group, and the role of the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 network in ESCA is supported. Biological processes related to immune functions, KMT2D mutation, CNV and the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 network were involved in ESCA progression.
lncRNA target	35281537	hsa-mir-665	Acute Kidney Injury	We revealed that miR-665 expression was increased in septic AKI, and silencing miR-665 could inhibit LPS-induced inflammation and apoptosis of the kidney by targeting Bcl-2, thereby improving renal function.
lncRNA target	35281530	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	5p was a key downstream target inducing the oncogenic role of SNHG1 in the OSCC process with KLF5 as its downstream gene.
lncRNA target	35281529	hsa-mir-1305	Lung Neoplasms	This paper aims to explore the lncRNA PROX1-AS1 effect on proliferation, migration, invasion, and apoptosis of lung cancer cells together with its targeted regulation on miR-1305.
genetics_knock down_promote	35281523	hsa-mir-107	Ovarian Neoplasms	The luciferase reporter assay proved overexpression of LINC-DUBR repressed cells proliferation and invasion via binding to miR-107 in ovarian cancer.
genetics_overexpression_promote	35281474	hsa-mir-877	Osteosarcoma	3p downregulation or CREBBP overexpression partly inverted the inhibitory effect of EVs by silencing NORAD on OS cell proliferation, invasion, migration, and angiogenesis.
lncRNA target	35281083	hsa-mir-381	Retinal Degeneration	Taken together, our study demonstrated that miR3p regulated RPCs proliferation and differentiation by targeting Hes1, which provides an experimental basis of RPCs transplantation therapy for retinal degeneration.
other	35281074	hsa-mir-155	Arthritis, Rheumatoid	INTRODUCTION: We previously reported a specific defect of rheumatoid arthritis (RA) monocyte polarization to anti-inflammatory M2-like macrophages related to increased miR-155 expression in all RA patients except those receiving adalimumab (ADA).
other	35281056	hsa-mir-218	DiGeorge Syndrome	We report miR5p upregulation in KP-EV of kidney transplant recipients with DGF.
other	35280778	hsa-mir-485	Stomach Neoplasms	3p-LYN-neurons.
other	35280778	hsa-mir-1269b	Stomach Neoplasms	3p-LYN-neurons.
other	35280778	hsa-mir-3686	Stomach Neoplasms	3p-LYN-neurons.
other	35280778	hsa-mir-5584	Stomach Neoplasms	3p-LYN-neurons.
other	35280778	hsa-mir-145	Stomach Neoplasms	3p-LYN-neurons.
other	35280778	hsa-mir-4537	Stomach Neoplasms	3p-LYN-neurons.
lncRNA target	35280693	hsa-mir-186	Colonic Neoplasms	Our study revealed that M2-EVs facilitates the growth and motility of CC cells by delivering the enclosed miR5p, which directly targets DLC1 mRNAs and facilitates their degradation, which could provide a potential biomarker and therapeutic target for CC.
circRNA target	35280687	hsa-mir-412	Carcinoma, Renal Cell	3p/PCDH7 axis, and suggest that circDVL1 could be a novel diagnostic and prognositc marker and therapeutic target for ccRCC.
lncRNA target	35280407	hsa-mir-874	Intervertebral Disc Degeneration	3p can inhibit the cell death of IDD, and not only participate in caspase-3 and Fas-associating protein with a novel death domain (FADD)-mediated apoptosis through targeted regulation of exogenous MMP2/MMP3 pathway, but also play a role in cell apoptosis through mitochondrial pathway.
lncRNA target	35280401	hsa-mir-199b	Melanoma	MiR-199b is a target gene of SNHG12, which was expressed at low levels in melanoma cell lines, and SNHG12 regulated melanoma cell proliferation, migration, and invasion through miR-199b. CONCLUSIONS: SNHG12 is highly expressed in melanoma, and promotes the expression of ETS1, PXN, JAG1, and DDR1 through targeted regulation of miR-199b, thereby promoting the proliferation, migration, and invasion of melanoma cells.
circulation_biomarker_diagnosis_ns	35280383	hsa-mir-93	Breast Neoplasms	5p directly targets the PD-L1/CCND1 signaling pathway to influence their accumulation and distribution in the cell membrane, nucleus, and cytoplasm, mediating tumor progression and immune regulation in BRCA.
lncRNA target	35280029	hsa-mir-3907	Meibomian Gland Carcinoma  	miR-3907 over-expression, miR-3907 knock-down, target gene knock-down and miR-3907 knock-down with target gene knock-down were respectively performed in MGC cell.
lncRNA target	35279965	hsa-mir-337	Uterine Cervical Neoplasms	CONCLUSION: Circ_0000228 up-modulates TGFBR1 by targeting miR
target gene	35279963	hsa-mir-625	Leukemia, Myeloid, Acute	Upregulation of hsa-miR-625-5p Inhibits Invasion of Acute Myeloid Leukemia Cancer Cells through ILK/AKT Pathway.
other	35279909	hsa-mir-486	Kidney Diseases	miR5p is implicated in cisplatin-induced kidney damage in vivo.
circRNA target	35279761	hsa-mir-129-2	Breast Neoplasms	Silencing of circ-TFF1 inhibited the malignant behavior of BC cells by releasing miR
lncRNA target	35279660	hsa-mir-590	Glioma	CONCLUSIONS: HCG11 suppresses glioma cells proliferation and migration through regulating the miR
other	35279605	hsa-mir-21	Intrahepatic Cholestasis of Pregnancy	CONCLUSION: Circ_0060731 mediated miR5p-PDCD4/ESR1 pathway could induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy.
lncRNA target	35279586	hsa-mir-124	late onset Parkinson's disease	In conclusion, SOS1-IT1 regulated the miR3p/PTEN/AKT/mTOR pathway to participate in the regulation of MPP(+)-induced neuronal cell injury, indicating the SOS1-IT1 might be an effective therapeutic target for PD.
lncRNA target	35279480	hsa-mir-664b	Pancreatic Carcinoma	Quantitative reverse transcription (qRTPCR) was used to measure the expression levels of HOXD-AS1, miR-664b-3p, and PLAC8. In conclusion, HOXD-AS1 was upregulated in PC tissues, promoting the proliferation, invasion, and migration of PC cells via the miR-664b-3p/PLAC8 axis.
other	35279460	hsa-mir-9	Anemia, Refractory, with Excess of Blasts	Furthermore, NFATC2 upregulated the phosphorylation of p65, thus activating the NF-kappaB pathway in RIOM; while miR3p reduced this effect.
genetics_knock down_promote	35279406	hsa-mir-197	Breast Neoplasms	Knockdown of miR-197 or activation of PPARG in BCSCs-EVs-treated cells significantly counteracted the promoting effect of BCSCs-EVs on BC cell growth and metastasis.
exosome	35279183	hsa-mir-21	Atherosclerosis	CONCLUSIONS: Our study demonstrated that ECFC-exosomes protect against atherosclerosis- or PTCA-induced vascular injury by rescuing autophagic flux and inhibiting SIAP1L2 expression through delivery of miR5p.
lncRNA target	35279164	hsa-mir-206	Intervertebral Disc Degeneration	These data suggested that miR-206/GJA1 might be potential therapeutic targets for IDD.
circRNA target	35279159	hsa-mir-186	Osteosarcoma	CONCLUSIONS: Abnormally high expression of circ_0001174 may promote the proliferation, migration, and invasion of OS cells through up-regulating MACC1 by sponging miR5p.
target gene	35279146	hsa-mir-149	Triple Negative Breast Neoplasms	LRP11-AS1 promotes the proliferation and migration of triple negative breast cancer cells via the miR-149-3p/NRP2 axis.
lncRNA target	35279145	hsa-mir-100	Colorectal Neoplasms	CONCLUSIONS: MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of TCF7L2 mRNA stability.
circulation_biomarker_diagnosis_down	35279129	hsa-mir-133a	Sepsis	Pearson's correlation coefficient analysis was utilized to analyze the correlation between circFADS2 and miR-133a levels across plasma samples from sepsis patients.
transcription factor target	35279083	hsa-mir-20a	Pulmonary Fibrosis	CONCLUSIONS: Our findings suggest that ALKBH5 promotes silica-induced lung fibrosis via the miR-320a-3p/FOXM1 axis or targeting FOXM1 directly.
genetics_overexpression_promote	35278814	hsa-mir-532	Colon   Adenocarcinoma	Overexpression of FJX1 could stimulate cell malignant behaviors of colon adenocarcinoma, whereas forced expression of miR
lncRNA target	35278613	hsa-mir-146a	Urinary Bladder Neoplasms	Moreover, METTL3/miR-146a-5p/NUMB/NOTCH2 axis plays an oncogenic role in bladder cancer pathogenesis and could be a potential therapeutic target for recurrent bladder cancer treatment.
circulation_biomarker_diagnosis_ns	35278480	hsa-mir-431	Alzheimer Disease	CONCLUSION: Our findings establish circ_0002945 as a crucial regulator of Abeta-induced neuron apoptosis and endoplasmic reticulum stress and uncover a novel circ_0002945/miR5p/TNFAIP1 ceRNA network for the Abeta pathogenic pathway in AD.
transcription factor target	35278407	hsa-mir-106a	Glomerulonephritis, IGA	At the cut-off >/= 800 copy per 1000 copies of housekeeping gene, urinary miR-106a has 100% sensitivity and 14.8% specificity in detecting IgA nephropathy. Conclusions We identified 6 miRNA targets whose urinary levels are significantly elevated in IgAN, and urinary miR-106a level has an excellent sensitivity for the identification of IgAN.
lncRNA target	35278365	hsa-mir-141	Angelman Syndrome	OIP5-AS1 indirectly increased HMGB1 expression in VSMCs by targeting miR
other	35278177	hsa-mir-192	Diabetic Nephropathies	In addition, the expression of miR-29a is significantly increased, whereas miR-192 decreased after treatment with KSCs (P < 0.05).
other	35278177	hsa-mir-29a	Diabetic Nephropathies	In addition, the expression of miR-29a is significantly increased, whereas miR-192 decreased after treatment with KSCs (P < 0.05).
transcription factor target	35278152	hsa-mir-629	Asthma	induced 16HBE cells' injury and inflammation by targeting FOXA2.
transcription factor target	35278152	hsa-mir-629	Inflammation	induced 16HBE cells' injury and inflammation by targeting FOXA2.
lncRNA target	35278064	hsa-mir-362	Carcinoma, Hepatocellular	In conclusion, this study demonstrates that ZC3H13 is a direct target of miR
lncRNA target	35278064	hsa-mir-425	Carcinoma, Hepatocellular	In conclusion, this study demonstrates that ZC3H13 is a direct target of miR
transcription factor target	35277920	hsa-mir-27b	Equine Infectious Anemia	RNA-sequencing analysis indicates that high miR-27b-3p expression levels in IAE may regulate macrophages by targeting macrophage colony-stimulating factor-1 (CSF-1).
circRNA target	35277867	hsa-mir-558	Pneumonia, Mycoplasma	Circ-OPHN1 and THBS2 levels were enhanced, while miR-558 level was declined in PE placental tissues. Circ-OPHN1 inhibited trophoblast cell proliferation, migration, and invasion through mediating miR-558/THBS2 axis, providing a novel pathway for PE pathogenesis.
lncRNA target	35277830	hsa-mir-95	Acute Lung Injury	In conclusion, MIR3142HG is increased in sepsis-induced ALI, and MIR3142HG could accelerate the progression of sepsis-induced ALI through miR5p/JAK2 axis, providing theoretical evidence for MIR3142HG to be a promising target for the therapeutics of ALI.
genetics_knock down_promote	35277830	hsa-mir-142	Acute Lung Injury	Knockdown of MIR3142HG facilitated cell viability but impaired cell apoptosis and inflammatory response via targeting miR
other	35277182	hsa-mir-199a	Carcinoma, Hepatocellular	CONCLUSIONS: Circ-ZEB1 promoted the expression of PIK3CA by depleting miR-199a-3p, thereby affecting HCC proliferation and apoptosis.
lncRNA target	35276698	hsa-mir-1272	Carcinoma, Renal Cell	The current findings demonstrated that circ_0003146 contributed to the malignant progression of ccRCC via inducing SCARB1 upregulation by targeting miR-1272.
genetics_overexpression_promote	35276697	hsa-mir-21	Ovarian Neoplasms	Meanwhile, PEG3 overexpression abrogated miR
circRNA target	35276696	hsa-mir-545	Colorectal Neoplasms	CircSAMD4A contributed to 5-Fu resistance of CRC cells partly through upregulating PFKFB3 expression by sponging miR3p, providing a possible circRNA-targeted therapy for CRC.
genetics_knock down_promote	35276693	hsa-mir-612	Nasopharyngeal Carcinoma	ZFPM2-AS1 knockdown considerably restrained NPC development via targeting the miR-3612/DTL signaling.
lncRNA target	35276351	hsa-mir-200a	Venous Thromboembolism	Moreover, miR-200a-5p might be a therapeutic target for VTE.
other	35276240	hsa-mir-122	Polycystic Ovary Syndrome	5p in the development of granulosa cells (GCs).
other	35276240	hsa-mir-122	Ovarian Diseases	In present study, we found that miR5p was highly expressed in chicken atrophic ovaries.
other	35276183	hsa-mir-142	Myopia	We aimed to explore the effect and regulatory mechanism of hsa-miR3p on collagen I in human scleral fibroblasts in high myopia.
other	35275699	hsa-mir-491	Gluteal Muscle Contracture	5p might be a potentially effective biomarker for predicting GMC, providing a novel therapeutic strategy for GMC.
other	35275699	hsa-mir-491	Diabetic Nephropathies	5p might be a potentially effective biomarker for predicting GMC, providing a novel therapeutic strategy for GMC.
circulation_biomarker_diagnosis_ns	35275615	hsa-mir-135b	Urinary Bladder Neoplasms	Furthermore, the simultaneous analysis of BC-related exosomal miR-133b and miR-135b in clinical serum specimens was achieved and consistent with qRT-PCR, suggesting it is a potential method for the diagnosis of BC and other cancers.
lncRNA target	35275525	hsa-mir-223	Angelman Syndrome	3p inhibited ox-LDL-mediated NLRP3 inflammasome activation via directly targeting NLRP3 and FOXO3 in THP-1 cells, which offered a prospective therapeutic target for AS therapy.
exosome	35275523	hsa-mir-138	Melanoma	5p from exosomes released by human mesenchymal stem cells (HMSCs) on the pathogenesis of melanoma.
lncRNA target	35275522	hsa-mir-224	Carcinoma, Non-Small-Cell Lung	Moreover, molecular mechanistic research suggested that miR-224 enhanced NSCLC by directly targeting the tumor suppressor angiopoietin-like protein (ANGPTL).
lncRNA target	35275356	hsa-mir-196	Adenocarcinoma of Lung	In conclusion, our findings suggest that MAFG-AS1/miR-3196/SOX12 axis regulates LUAD progression and is a potential therapeutic target for LUAD.
genetics_knock down_suppress	35275355	hsa-mir-483	Glioma	3p expression and SOX3 overexpression reversed the biological effects of LINC00662 knockdown on glioma cells.
genetics_overexpression_suppress	35275273	hsa-mir-518c	Endometriosis	A rat model of EMs overexpressing miR-518c-3p alone or ZNF608 simultaneously was constructed to detect ectopic endometrial cell apoptosis and cyst volume in rats.
lncRNA target	35274813	hsa-mir-582	Cholangiocarcinoma	Finally, we showed that YAP1 was a target of NKILA via miR3p and NKILA functioned partially via YAP1 in CCA.
circRNA target	35274779	hsa-mir-217	Uterine Cervical Neoplasms	CONCLUSION: circ_0119412 functioned as an oncogenic driver to promote the malignant development of cervical cancer by targeting the miR-217/AGR2 pathway.
other	35274778	hsa-mir-7974	Femur Head Necrosis	CONCLUSIONS: hsa_circ_0058122/miR-7974/IGFBP5 was proposed to be a key regulatory pathway for SONFH.
genetics_knock down_promote	35274735	hsa-mir-19b	Carcinoma, Non-Small-Cell Lung	Whilst overexpression of miR-19b-3p was demonstrated to promote the proliferation and invasion of NSCLC cells, knockdown of miR-19b-3p showed an opposite inhibitory effect.
lncRNA target	35274504	hsa-mir-92a	Acute Lung Injury	CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively.
lncRNA target	35274504	hsa-mir-92a	Erectile Dysfunction, Diabetic	CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively.
lncRNA target	35274504	hsa-mir-92a	Diabetes Mellitus, Type 2	CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively.
lncRNA target	35274492	hsa-mir-660	Melanoma	The mechanism study showed that circITCH-sponged miR-660 to upregulate TFCP2 and suppress melanoma progression. CONCLUSIONS: The circITCH/miR-660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma.
other	35274397	hsa-mir-141	Osteosarcoma	In summary, this study suggested that the expression of SNHG10 markedly elevated within OS, and the SNHG10/miR3p/WTAP axis facilitated OS progression.
genetics_overexpression_promote	35274138	hsa-mir-29a	Diabetic Cardiomyopathies	Compared with control group, the protein expression of Bax, cleaved-caspase3 and Bak1 in DCM and HG groups were significantly upregulated, and the expression of Bcl-2 and Mcl-1 was downregulated, while miR-29a overexpression exerted opposite effect.
transcription factor target	35274048	hsa-mir-29a	Breast Neoplasms	They were targeted by hsa-miR-29a/c, and the expression levels of hsa-miR-29a/c were associated with a poor prognosis of BCa.
circulation_biomarker_diagnosis_up	35274002	hsa-mir-29b	Inflammatory Bowel Diseases	Excessive plasma exosomal miR-29b suppresses critical proteins like BDNF in IBD, leading to cardiac impairment.
target gene	35273739	hsa-mir-193a	Colorectal Neoplasms	Over-expression of miR-193a-3p regulates the apoptosis of colorectal cancer cells by targeting PAK3.
other	35273726	hsa-mir-24	Melanoma	HCG18 was found to reverse the effect of miR5p by upregulating CDK16 expression in melanoma cell proliferation, apoptosis, migration and invasion in vitro.
other	35273698	hsa-mir-24	Colonic Neoplasms	VPS9D1-AS1, a novel long-non-coding RNA, acts as a tumor promoter by regulating the miR-324-5p/ITGA2 axis in colon adenocarcinoma.
other	35273693	hsa-let-7c	Down Syndrome	In order to further understand the potential roles of miRNAs in the pathogenesis of AD, we analyzed Down syndrome (DS), a special model of AD, by using a TaqMan microRNA array and found that miRNA let-7c was up-regulated in both DS and AD.
lncRNA target	35273692	hsa-mir-127	Carcinoma, Non-Small-Cell Lung	BACKGROUND: This study set out to explore the regulatory relationship between LINC00961/miR-3127 axis and non-small-cell lung carcinoma (NSCLC), so as to provide a new and effective molecular target for targeted therapy of NSCLC.
lncRNA target	35273690	hsa-mir-409	Colonic Neoplasms	Our results confirmed that LINC00630 regulates proliferation, glycolysis, and apoptosis mainly through targeting the miR
other	35273684	hsa-mir-1275	Multiple Sclerosis	Finally, by analyzing LINC00649-miRCD20, we identified 6 drugs that may represent novel drugs for MS.
circulation_biomarker_diagnosis_up	35273615	hsa-mir-140	Encephalitis, Viral	5p combined with serum C3 would be a promising marker in the differential diagnosis of anti-NMDAR encephalitis with VE.
other	35273591	hsa-mir-423	lung squamous cell carcinoma	5p axes.
genetics_knock down_promote	35272674	hsa-mir-889	Stomach Neoplasms	Moreover, GC cells were subjected to ectopic expression and knockdown manipulations of circDYRK1A, miR
genetics_knock down_promote	35272621	hsa-mir-185	Myocardial Reperfusion Injury	CONCLUSION: LINC00461 knockdown attenuates myocardial I/R injury via elevating miR
genetics_GWAS	35272550	hsa-mir-140	Vascular Calcification	5p, toll like receptor 4 (TLR4) and vascular calcification-related proteins (alpha-smooth muscle actin, alpha-SMA; Msh Homeobox 2, MSX2; bone morphogenetic protein 2, BMP2; Kruppel-like factor 4, KLF4; Runt-related transcription factor 2, RUNX2) were measured through quantitative real time polymerase chain reaction (qRT-PCR) and western blot.
circulation_biomarker_diagnosis_ns	35272213	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Moreover, the developed method is successfully applied to evaluate the expression level of miRNA-21 in serum of NSCLC patients.
other	35272010	hsa-mir-223	Conjunctivitis, Allergic	This study aims to explore the clinical implications of miR-223 in allergic conjunctivitis (AC) and the related factors affecting disease recurrence. These results indicate that miR-223 plays an important role in the pathology of allergic conjunctivitis.
exosome	35271999	hsa-mir-140	Obesity	In summary, the current study provides evidence that obese ATM-exosomal miR
exosome	35271999	hsa-mir-140	Heart Injuries	In summary, the current study provides evidence that obese ATM-exosomal miR
other	35271943	hsa-mir-101	Silicotuberculosis	3p and then up-regulate the expression of ZEB1, thus promoting the EMT process of alveolar epithelial cells in the process of silicosis-related pulmonary fibrosis EMT.
lncRNA target	35271760	hsa-mir-16	Cholangitis, Sclerosing, Primary	Targeting the FGF1 and miR-16 axis may provide therapeutic options in treating cholangiopathies such as PSC.
lncRNA target	35271760	hsa-mir-16	Liver Cirrhosis	Targeting the FGF1 and miR-16 axis may provide therapeutic options in treating cholangiopathies such as PSC.
other	35271662	hsa-mir-155	Diabetes Mellitus, Type 2	In addition, according to the TF-gene interactions network and TF-miRNA coregulatory network, part of TF and miRNA may be identified as key regulator in sarcopenia and T2DM at the same time (e.g., CREM and miR-155).
other	35271662	hsa-mir-155	Sarcopenia	In addition, according to the TF-gene interactions network and TF-miRNA coregulatory network, part of TF and miRNA may be identified as key regulator in sarcopenia and T2DM at the same time (e.g., CREM and miR-155).
other	35271544	hsa-mir-541	Acute Lung Injury	5p is a key effector in ALI tissue, and that LPS-induced ATII cells act by regulating HMGB1 expression.
genetics_GWAS	35270805	hsa-mir-146a	Polycystic Ovary Syndrome	This study has characterized the clinical parameters in PCOS patients with comprehensive biochemical profiling compared to healthy controls and further examined the influence of allelic variations for estrogen receptor-alpha (ESR1 PvuII-rs2234693 T>C) and miRNA-146a (rs2910164 C>G) gene polymorphism on the risk of and susceptibility to PCOS. On the contrary, the study found strong association of miRNA-146a (rs2910164 C>G) gene polymorphism with an enhanced risk of PCOS.
transcription factor target	35270010	hsa-mir-124	ACTH-Secreting Pituitary Adenoma	5p and lower expression of their target genes NR3C1 and NR3C2.
transcription factor target	35269968	hsa-mir-661	Glioblastoma	This process was inhibited in gliomas due to the low expression of miR-661.
other	35269913	hsa-mir-200c	Cytomegalovirus Infections	We used miR-200b-3p/miR-200c-3p mimics to counteract the downregulation of these miRNA after acute HCMV infection. Overall, miR-200b-3p and miR-200c-3p-together with p-Ser(536) RelA/p65-can prevent lytic HCMV replication during acute and latent infection.
other	35269913	hsa-mir-200b	Cytomegalovirus Infections	We used miR-200b-3p/miR-200c-3p mimics to counteract the downregulation of these miRNA after acute HCMV infection. Overall, miR-200b-3p and miR-200c-3p-together with p-Ser(536) RelA/p65-can prevent lytic HCMV replication during acute and latent infection.
lncRNA target	35269749	hsa-mir-124	Pancreatic Carcinoma	We also elucidated the mechanism underlying SEMA6C downregulation in pancreatic cancer and demonstrated a novel regulatory role of miR3p in suppressing SEMA6C.
genetics_overexpression_suppress	35269556	hsa-mir-375	Pheochromocytoma	We also demonstrated miR-375 overexpression and downregulated (Wnt) signaling and identified the Hippo pathway as a new potentially oncogenic feature of Pheo.
other	35269443	hsa-let-7	Carcinoma, Ovarian Epithelial	We confirmed this finding and observed that T308 phosphorylation was yet further reduced in EOC spheroids and that the transition from adherent to spheroid growth is accompanied by significantly increased levels of let-7 miRNAs.
other	35267449	hsa-mir-24-1	Prostatic Neoplasms	1-5p in prostate cancer cases.
other	35267420	hsa-mir-1271	Carcinoma, Renal Cell	5p, and miR-15b-5p levels and three controls.
other	35267420	hsa-mir-15b	Carcinoma, Renal Cell	5p, and miR-15b-5p levels and three controls.
other	35267420	hsa-mir-122	Carcinoma, Renal Cell	5p, and miR-15b-5p levels and three controls.
transcription factor target	35267120	hsa-mir-148a	Carcinoma, Hepatocellular	These data suggest that miR-148a may serve as a therapeutic target for HCC cancer therapy in the future.
other	35266915	hsa-mir-7a	Heart Diseases	Ppp1r16b networks), which may be a novel mechanism of sevoflurane-induced cardioprotection.
lncRNA target	35266884	hsa-mir-1236	Breast Neoplasms	3p could suppress BC cell proliferation, metastasis and glycolysis, while this effect could be abolished by PFKFB3.
genetics_knock down_promote	35266852	hsa-mir-98	Stomach Neoplasms	TTTY15 knockdown inhibited gastric cancer cell proliferation but promoted apoptosis by sponging miR
lncRNA target	35266447	hsa-mir-320d	Osteosarcoma	Additionally, repressive LINC00641 blocked MCL1 via emulative interaction with miR-320d, thus expediting DDP-sensitivity of OS cells. All in all, it is found that LINC00641 is available to escalate drug resistance of DDP-resistant OS cells via mediation of miR-320d/MCL1 axis.
lncRNA target	35266446	hsa-mir-125a	Adenocarcinoma of Lung	Overall, our study revealed that LINC01426 might regulate the malignant phenotype of LUAD via the miR-125a-5p/CSNK2A1 axis.
genetics_overexpression_promote	35266369	hsa-mir-19a	Colorectal Neoplasms	In conclusion, our results revealed that miR-19a overexpression decreases CLCA4 levels to promote CRC oncogenesis, suggesting that miR-19a inhibitors have potential applications for future therapeutic of CRC.
genetics_overexpression_promote	35266110	hsa-mir-221	Glioma	Overexpression of SLC25A21-AS1 inhibited glioma progression via miR
genetics_overexpression_promote	35266110	hsa-mir-222	Glioma	Overexpression of SLC25A21-AS1 inhibited glioma progression via miR
other	35265764	hsa-mir-191	Malaria, Vivax	The expression of miR-191 was 1.405 times higher in patients with malaria compared to that in the controls, although the difference was statistically insignificant.
other	35265629	hsa-mir-137	Colonic Neoplasms	The microRNA shared by BCL2A1 and PD-L1, hsa-miR-137, were significantly associated with CCL18, BCL2A1, and PD-L1, and downregulated in low-IC50 group.
genetics_knock down_suppress	35265621	hsa-mir-124	Choroidal Neovascularization	Mechanistically, through the lncRNA-RNA binding protein-miRNA interaction analysis involving loss of function and gain-of-function experiments, we found that lncRNA PNKY inhibited the binding of miR124 to PTBP1 and maintained the homeostasis of choroidal vascular function by promoting Bcl-2 like protein 11 (BIM), and its dysfunction led to exacerbation of CNV lesion. Therefore, this study suggests that the lncPNKY/PTBP1-miR-124 axis is involved in regulating the development of CNV, providing a potential therapeutic target for the treatment of CNV.
circulation_biomarker_diagnosis_ns	35265305	hsa-mir-196b	Pregnancy, Ectopic	qRT-PCR showed that miR-196b expression in peripheral blood of EP patients was lower than that of normal people.
exosome	35265076	hsa-mir-885	Graves Ophthalmopathy	Exosome mir
exosome	35265076	hsa-mir-4474	Graves Ophthalmopathy	3p were downregulated in the exosomes of SI patients.
exosome	35265076	hsa-mir-615	Graves Ophthalmopathy	3p were downregulated in the exosomes of SI patients.
lncRNA target	35264957	hsa-mir-18a	Carcinoma, Hepatocellular	In addition, a rescue experiment found miR-18a-3p mimic partly reversed the suppression of hsa_circ_0098181 on proliferation, invasion, and migration of HCC cell lines. In conclusion, hsa_circ_0098181 can repress the development of HCC through sponging miR-18a-3p and promoting the expression of PPARA in vitro and in vivo, and hsa_circ_0098181 might be a therapeutic target for HCC.
circulation_biomarker_diagnosis_ns	35264879	hsa-mir-96	Carcinoma, Hepatocellular	These findings suggested that serum miRNA
circulation_biomarker_diagnosis_ns	35264879	hsa-mir-99a	Carcinoma, Hepatocellular	These findings suggested that serum miRNA
circulation_biomarker_diagnosis_ns	35264708	hsa-mir-155	Brucellosis	Taken together, data from this study indicate that Brucella infection affects miR-155 expression and that human brucellosis patients show decreased serum levels of miR-155.
circulation_biomarker_diagnosis_ns	35264203	hsa-mir-9	Depression	5p expression levels in serum exosomes from MDD patients than healthy control (HC) subjects.
transcription factor target	35264186	hsa-mir-378	Glomerulonephritis, Membranoproliferative	CONCLUSION: UcMSC-Evs ameliorate pathological process in MsPGN through the delivery of miR-378, which suppresses PSMD14-mediated TGFBR1 stability and inactivates the TGF-beta1/Smad2/3 signaling pathway to reduce tissue hyperplasia and rMC proliferation.
lncRNA target	35264092	hsa-mir-29a	Osteoarthritis	CONCLUSION: In conclusion, this work highlights the role of the POU3F3/miR-29a-3p/FOXO3 axis in the OA pathogenesis, suggesting this axis as a potential therapeutic target for OA.
genetics_overexpression_promote	35264071	hsa-mir-515	Thyroid Neoplasms	5p repressed the Smad4 expression level, consequently reversed the inhibiting effect of overexpressed CATIP-AS1 on the proliferation, and migration of THCA cell.
other	35264070	hsa-mir-26b	Osteosarcoma	In conclusion, Circ_ANKIB1 binds miR-26b-5p and modulates EZH2 to accelerate the chemo-resistance of osteosarcoma.
lncRNA target	35264067	hsa-mir-409	Glioma	PDK1 acted as a target gene of miR
lncRNA target	35264065	hsa-mir-129	Thyroid Cancer, Papillary	LARP1, a downstream target of miR
other	35264058	hsa-mir-338	Acute Lung Injury	Collectively, our study indicates that circ_0001679/miR3p/MAPK1 axis may play an important role in the pathogenesis of acute lung injury (ALI).
other	35263585	hsa-mir-130a	Leukemia, Myeloid, Acute, T-Cell	Moreover, we report that miR-130a is highly expressed in t(8;21) acute myeloid leukemia (AML), where it is critical for maintaining the oncogenic molecular program mediated by the AML1-ETO complex.
circulation_biomarker_diagnosis_up	35263556	hsa-mir-181a	Fractures, Bone	The binding between SNHG1/miR-181a-5p/PTEN was detected by dual-luciferase reporter gene assay.Results: Serum SNHG1 and PTEN expression were upregulated and miR-181a-5p expression was downregulated in patients with delayed fracture healing. Finally, elevated SNHG1 was a feasible predictive biomarker in patients with delayed fracture healing.Conclusion: The current study revealed that SNHG1/miR-181a-5p/PTEN axis inhibited osteoblast differentiation and proliferation and promoted apoptosis, thus leading to the inhibition of tibial fracture healing.
lncRNA target	35263556	hsa-mir-181a	Tibial Fractures	Finally, elevated SNHG1 was a feasible predictive biomarker in patients with delayed fracture healing.Conclusion: The current study revealed that SNHG1/miR-181a-5p/PTEN axis inhibited osteoblast differentiation and proliferation and promoted apoptosis, thus leading to the inhibition of tibial fracture healing.
other	35262985	hsa-mir-139	Mouth Neoplasms	5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue.
other	35262985	hsa-mir-1	Mouth Neoplasms	5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue.
lncRNA target	35262876	hsa-mir-559	Ovarian Neoplasms	MiR-559 expression was remarkably reduced in OC tissues and cell lines, and miR-559 markedly suppressed the malignant characteristics of OC cells. CCNB1, of which expression is modulated by miR-559, facilitates proliferation, migration, and invasion of OC cells, therefore, working as a potential therapeutic target of OC.
lncRNA target	35262384	hsa-mir-143	Corneal Injuries	In addition, either LINC00963 promotion or miR3p inhibition could significantly decrease myofibroblast contractility and collagen I and III secretion, which are the key to contribute to corneal fibrosis.
target gene	35261900	hsa-mir-450b	Carcinoma, Non-Small-Cell Lung	Circular RNA circTADA2A promotes the proliferation, invasion, and migration of non-small cell lung cancer cells via the miR-450b-3p/HMGN5 signaling pathway.
lncRNA target	35261804	hsa-mir-335	Opitz GBBB Syndrome, X-Linked	In addition, SNHG15 suppresses cisplatin-induced apoptosis and ROS accumulation through the miR3p/ZNF32 pathway.
lncRNA target	35261562	hsa-mir-9	Non-alcoholic Fatty Liver Disease	5p in NAFLD-EVs alleviated macrophage inflammation and M1 polarization as evidenced by reduced levels of macrophage inflammatory factors, positive rates of CD86(+) CD11b(+), and levels of macrophage surface markers in vitro.
circulation_biomarker_diagnosis_ns	35261213	hsa-mir-200b	Ischemic Attack, Transient	CONCLUSION: Serum miR-200b-3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls.
circulation_biomarker_diagnosis_ns	35261213	hsa-mir-200b	Cerebral Infarction	CONCLUSION: Serum miR-200b-3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls.
transcription factor target	35260928	hsa-mir-21	Carcinoma, Squamous Cell	PDCD4 axis via (1)O(2) induced by HMME-PDT.
circulation_biomarker_diagnosis_up	35260775	hsa-mir-126	Kidney Failure, Chronic	This study showed for the first time that there is a dysregulation of whole blood miR
lncRNA target	35260554	hsa-mir-556	Stomach Neoplasms	KCNQ1OT1, microRNA (miR)3p and CLIC1 expression of GC tissues was detected through RT-qPCR.
genetics_knock down_promote	35260183	hsa-mir-189	Glioblastoma	mediated GLUT3 inhibition shows an anti-tumorigenic effect and cell death by regulating glucose metabolism in HDAC2 knockdown GBM.
genetics_overexpression_promote	35260141	hsa-mir-765	Colonic Neoplasms	The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765.
genetics_overexpression_suppress	35260066	hsa-mir-129-2	Esophageal Neoplasms	2-3p repressed EC cell progression while further overexpressing DNMT3B would restore the above inhibitory effect.
lncRNA target	35260044	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	FAM83H-AS1 favors non-small cell lung cancer by targeting the miR3p/HS6ST2 axis, supporting the possibility of developing FAM83H-AS1 as a target for NSCLC intervention.
other	35260041	hsa-mir-29b	Osteoarthritis	RESULTS: MiR-29b-3p level was upregulated in cartilage tissues of OA patients (3.5-fold change, p < 0.001) and IL-1beta stimulated chondrocytes (two fold change, p < 0.001).
circRNA target	35259622	hsa-mir-19a	Pneumonia, Mycoplasma	Oxidative injury-mediated placental trophoblast dysfunction in PE was through competing endogenous RNA (ceRNA) mechanism of CircFN1-miR-19a/b-3p-ATF2 axes.
circRNA target	35259622	hsa-mir-19b	Pneumonia, Mycoplasma	Oxidative injury-mediated placental trophoblast dysfunction in PE was through competing endogenous RNA (ceRNA) mechanism of CircFN1-miR-19a/b-3p-ATF2 axes.
transcription factor target	35259612	hsa-mir-134	Hypoxia-Ischemia, Brain	CONCLUSION: This study demonstrates that Dex treatment can alleviate HIBD in neonatal rats through restoring NLRX1 expression by suppressing miR
lncRNA target	35259352	hsa-mir-153	Stress Disorders, Post-Traumatic	The downregulation of miR-153 could alleviate the PTSD-like behaviors in the rats exposed to SPS, and this effect might be related to the upregulation of sigma-1R and PSD95. The results of this study indicated that miR-153 might alleviate PTSD-like behaviors by regulating cell morphology and reducing cell apoptosis in the hippocampus of rats exposed to SPS by targeting sigma-1R, which might be related to the mTOR signaling pathway.
lncRNA target	35259061	hsa-mir-1	Pre-Eclampsia	Collectively, our study demonstrated that lncRNA SNHG5 alleviated the PE phenotype and inhibited trophoblast autophagy by sponging miR5p and promoting SPARC transcription.
transcription factor target	35259053	hsa-mir-103a	Syphilis	All in all, BBR represses Wnt/beta-catenin pathway activation via modulating the miR-103a-3p/BRD4 axis, thereby mitigating colitis-stimulated pyroptosis and the intestinal mucosal barrier defect.
transcription factor target	35259053	hsa-mir-103a	Colitis	All in all, BBR represses Wnt/beta-catenin pathway activation via modulating the miR-103a-3p/BRD4 axis, thereby mitigating colitis-stimulated pyroptosis and the intestinal mucosal barrier defect.
genetics_knock down_promote	35259051	hsa-mir-141	Retinoblastoma	3p overexpression increased retinoblastoma growth and angiogenesis, which is partially reversed when SUSD2 is over-expressed both in vivo and in vitro.
lncRNA target	35259044	hsa-mir-16	Endometrial Neoplasms	Results indicated hsa-miR-497/16-5p expression were down-regulated, and mechanistic target of rapamycin kinase (mTOR) was up-regulated in EC. In conclusion, hsa_circ_0011324 could sponge hsa-miR-497/16-5p targeted mTOR to participate in EC progress.
lncRNA target	35259044	hsa-mir-497	Endometrial Neoplasms	Results indicated hsa-miR-497/16-5p expression were down-regulated, and mechanistic target of rapamycin kinase (mTOR) was up-regulated in EC. In conclusion, hsa_circ_0011324 could sponge hsa-miR-497/16-5p targeted mTOR to participate in EC progress.
lncRNA target	35258413	hsa-mir-186	Colonic Neoplasms	3p/KRT18 axis may be a promising therapeutic target for colon carcinoma.Abbreviations: KRT18: keratin 18; NC: negative control; si: small interfering RNA; inhibitor: miR
genetics_knock down_suppress	35258410	hsa-mir-455	Squamous Cell Carcinoma of Head and Neck	3p or ELF3 knockdown was shown to be capable of reversing the anti-tumor effects of LINC00472 in OSCC.
genetics_overexpression_promote	35258403	hsa-mir-486	Glioblastoma	5p overexpression suppressed cell growth, migration, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis in GBM cells in vitro and in vivo.
genetics_knock down_promote	35258395	hsa-mir-1301	Carcinoma, Hepatocellular	3p overexpression or METTL3 knockdown could partially counteract hsa_circ_0008583 overexpression-mediated influence on HCC cell behaviors.
genetics_knock down_promote	35258173	hsa-mir-130a	Carcinoma, Renal Cell	Both miR-130a-3p inhibitor and ESCO2 overexpression could rescue the inhibitory effects of ZFPM2-AS1 knockdown in RCC cells.
other	35257808	hsa-mir-551b	Reperfusion Injury, Cerebral Ischemia	Taken together, experimental data reveals a direct link between miR-551b-5p and BDNF-mediated signaling cascade in early convalescence of stroke.
lncRNA target	35257356	hsa-mir-21	Premature Birth	Overall, the study findings indicate that miR-21 may contribute to the pathogenesis of infection-induced PTB by upregulating the target NF-B and that miR-21 may be a new potential therapeutic target for infection-induced PTB.
other	35257310	hsa-mir-221	Thyroid Neoplasms	Our study provided the new insights into the mechanism by which miR3p functions in the development of TC.
exosome	35257299	hsa-mir-5627	Spinal Cord Injuries	In conclusion, MSCs-exosomes lncGm36569 inhibited neuronal cell ferroptosis through miR5p/FSP1 axis, thereby attenuating neuronal dysfunction.
other	35257270	hsa-mir-191	Cardiomyopathies	"5p/TRAF3 signaling, which might provide some convincing evidences for further understanding the influences of ""lncRNA-miRNA-mRNA"" network in the development of MI."
circulation_biomarker_diagnosis_ns	35257132	hsa-mir-486	Lung Neoplasms	The sensor can achieve single, dual, and triple biomarker detections of three lung cancer-related nucleic acid and protein biomarkers, i.e., miRNA-21, miRNA-486 and carcinoembryonic antigen (CEA) in human serum.
exosome	35256956	hsa-mir-29	Lung Neoplasms	Indeed, our clinical lung tumor data shows that miR-29a-3p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients' outcomes. In this study, we found that the chemotherapy drug cisplatin facilitated miR-29a-3p accumulation in the exosomes of lung tumor cells, and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.
exosome	35256956	hsa-mir-29a	Lung Neoplasms	Indeed, our clinical lung tumor data shows that miR-29a-3p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients' outcomes. In this study, we found that the chemotherapy drug cisplatin facilitated miR-29a-3p accumulation in the exosomes of lung tumor cells, and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.
other	35256892	hsa-mir-551b	Pancreatitis, Acute Hemorrhagic	OBJECTIVE: This study focused on investigating the effects of microRNA551b-5p (miR-551b-5p) on severe acute pancreatitis.
transcription factor target	35256888	hsa-mir-136	Epilepsy, Temporal Lobe	CONCLUSION: miR-136 could exert its neuroprotective influence on temporal lobe epilepsy rats by inhibiting the Wnt/beta-catenin signaling pathway.
lncRNA target	35256884	hsa-mir-1301	Pancreatic Carcinoma	3p suppressed the proliferation and migration abilities of PC cells.
lncRNA target	35256585	hsa-mir-185a	Osteoarthritis	Interestingly, we found that the anabolic activities of melatonin involved the MT(1) receptor, which upregulated microRNA-185a through the PI3K/Akt and ERK signaling pathways in OA synovial fibroblasts.
lncRNA target	35256570	hsa-mir-5194	Melanoma	Finally, LINC01063 was tested to facilitate the malignant behaviors of melanoma cells via targeting miR-5194/SOX12. Our study revealed the oncogenic effects of LINC01063 on melanoma cell/tumor growth and its molecular mechanism involving miR-5194/SOX12, which might support LINC01063 to be the potential prognostic or therapeutic biomarker against melanoma.
transcription factor target	35255935	hsa-mir-875	Stomach Neoplasms	5p inhibited the proliferation, migration and invasion of GC cells in vitro and inhibited tumorigenesis in vivo.
lncRNA target	35255921	hsa-mir-423	Esophageal Squamous Cell Carcinoma	5p/PAK6 axis may serve as promising diagnostic and prognostic biomarkers and therapeutic targets for ESCC.
therapeutic target	35255904	hsa-mir-497	Breast Neoplasms	DNA methyltransferase 1 inhibits microRNA-497 and elevates GPRC5A expression to promote chemotherapy resistance and metastasis in breast cancer.
circulation_biomarker_diagnosis_up	35255856	hsa-mir-204	Hypertension	miR-204 level in the serum was positively correlated with TNF-alpha, IL-6, and hs-CRP concentrations in HDCP patients.
other	35255782	hsa-mir-21	Carcinoma, Renal Cell	CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC.
other	35255782	hsa-mir-1233	Carcinoma, Renal Cell	CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC.
other	35255782	hsa-mir-378	Carcinoma, Renal Cell	CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC.
other	35255782	hsa-mir-210	Carcinoma, Renal Cell	CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC.
tissue_expression_down	35255737	hsa-mir-379	Osteoarthritis	Safranin O-fast green staining, immunohistochemistry, and WB were performed to observe the effect of miR
other	35255686	hsa-mir-153	Myocardial Infarction	3p by nHA-CLPs.
transcription factor target	35254877	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	In conclusion, RSV prevents HFD-induced insulin resistance and hepatic steatosis by suppressing miR-34a-induced activation of SIRT1.
transcription factor target	35254825	hsa-mir-383	Dengue	Herein, we discovered that miR5p targets certain lipid and cholesterol biosynthetic pathways and restricts Dengue virus (DENV) infection in hepatic cells.
lncRNA target	35254597	hsa-mir-139	Carcinoma, Hepatocellular	5p/ENAH is hopefully to be the possible target for HCC patients.
transcription factor target	35254116	hsa-mir-518a-2	Lung  Adenocarcinoma	We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD).
transcription factor target	35254116	hsa-mir-188	Lung  Adenocarcinoma	We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD).
transcription factor target	35254116	hsa-mir-23	Lung  Adenocarcinoma	We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD).
lncRNA target	35253975	hsa-mir-155	Retinoblastoma	The data in this study suggest that MIR17HG exerts oncogenic effects in RB via the miR
other	35253734	hsa-mir-1	Colorectal Neoplasms	MiR5p and RAB27B could also predict the overall survival of MSS CRCs.
lncRNA target	35253605	hsa-mir-21	Pancreatic Carcinoma	Curcumol inhibited growth of xenograft-tumors and the biological activities of pancreatic cancer cells by regulating the miR
other	35253371	hsa-mir-29	Intestinal Diseases	CONCLUSIONS: We reveal that M-sEVs and miR-29 can accelerate intestinal stem cell-mediated epithelial regeneration and repair epithelial damage.
other	35253371	hsa-mir-29a	Intestinal Diseases	CONCLUSIONS: We reveal that M-sEVs and miR-29 can accelerate intestinal stem cell-mediated epithelial regeneration and repair epithelial damage.
other	35253153	hsa-mir-199a	Spinal Cord Injuries	CONCLUSION: LncRNA MALAT1 promotes neuronal apoptosis during SCI by regulating the miR-199a-5p/PRDM5 axis.
other	35252868	hsa-mir-486-1	Tongue Neoplasms	We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples.
other	35252868	hsa-mir-451a	Tongue Neoplasms	We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples.
other	35252868	hsa-mir-675	Tongue Neoplasms	We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples.
circRNA target	35252543	hsa-mir-153	Hyalinosis, Systemic	Ultimately, we showed that circRNA-0100 promoted the differentiation of SHF-SCs into hair lineage, which might be achieved via sequestering miR
other	35252169	hsa-mir-762	Stomach Neoplasms	Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis.
circRNA target	35252056	hsa-mir-128	Carcinoma, Hepatocellular	3p/c-Met axis may be potential therapeutic targets for circumventing lenvatinib resistance in HCC and warrant further investigation.
exosome	35251967	hsa-mir-125a	Nasopharyngeal Carcinoma	Overall, the current study shows that MSCs can be utilized to generate exosomes with high miR-125a level, which could be therapeutic nanoparticles targeting VM formation in nasopharyngeal carcinoma and used as a complement to anti-angiogenic therapy in the future.
lncRNA target	35251919	hsa-mir-7	Lung Neoplasms	Our study not only delineates how acidification directly affects tumorigenesis, but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer (NSCLC) treatment.
circulation_biomarker_diagnosis_ns	35251580	hsa-mir-122	Hepatitis B	In HBV sufferers, the serum miR-122 expression level is related to liver disease progression, hence making it an underlying molecular biomarker for predicting the development of CHB.
genetics_overexpression_suppress	35251568	hsa-mir-186	Breast Neoplasms	Overexpression of CXCL13 can significantly neutralize the inhibitory effects of miRNA
other	35251503	hsa-mir-21	Hip Fractures	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-122	Hip Fractures	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-21	Osteoporosis	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-125b	Osteoporosis	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-122	Osteoporosis	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-140	Hip Fractures	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-140	Osteoporosis	5p and miR-125b-5p were down-regulated.
other	35251503	hsa-mir-125b	Hip Fractures	5p and miR-125b-5p were down-regulated.
lncRNA target	35251377	hsa-mir-1	Nasopharyngeal Neoplasms	miR-1 has the potential to be a therapeutic target for NPC.
target gene	35251354	hsa-mir-148a	Carcinoma, Non-Small-Cell Lung	miR-148a promotes cell sensitivity through downregulating SOS2 in radiation-resistant non-small cell lung cancer cells.
genetics_overexpression_suppress	35251300	hsa-mir-498	Carcinoma, Hepatocellular	miR-498 was overexpressed in hepatoma cells, and then, flow cytometry was used to analyze the cell apoptosis rate.
other	35251139	hsa-mir-181c	Breast Neoplasms	We then constructed a ceRNA network, which identified an lncRNA LINC00665/miR-181c-5p/BCL2 regulatory axis for BRCA. We also constructed a ceRNA network and identified an lncRNA LINC00665/miR-181c-5p/BCL2 regulatory axis for BRCA.
other	35250545	hsa-mir-155	Cognitive Dysfunction	Some of the associated genes and miRNAs were shown to interact within the signaling pathways of APP (Amyloid Precursor Protein), ACE2 (Angiotensin Converting Enzyme 2), miR-155 and PPARG (Peroxisome Proliferator Activated Receptor Gamma), which are known to contribute to neuroinflammation and neurodegeneration.
other	35250545	hsa-mir-155	Alzheimer Disease	Some of the associated genes and miRNAs were shown to interact within the signaling pathways of APP (Amyloid Precursor Protein), ACE2 (Angiotensin Converting Enzyme 2), miR-155 and PPARG (Peroxisome Proliferator Activated Receptor Gamma), which are known to contribute to neuroinflammation and neurodegeneration.
lncRNA target	35250291	hsa-mir-126	Pulmonary Disease, Chronic Obstructive	This study aimed to explore the potential role of endothelial microparticles (EMPs) derived from primary pulmonary microvascular endothelial cells in regulating lung inflammation of chronic obstructive pulmonary disease (COPD) through transferring microRNA-126 (miR-126). CONCLUSION: The present study reveals that EMPs are capable of alleviating lung inflammation and transferring miR-126 can magnify the anti-inflammatory effect of EMPs, which may provide a novel therapeutic alternative for COPD.
lncRNA target	35250291	hsa-mir-126	Pneumonia	This study aimed to explore the potential role of endothelial microparticles (EMPs) derived from primary pulmonary microvascular endothelial cells in regulating lung inflammation of chronic obstructive pulmonary disease (COPD) through transferring microRNA-126 (miR-126). CONCLUSION: The present study reveals that EMPs are capable of alleviating lung inflammation and transferring miR-126 can magnify the anti-inflammatory effect of EMPs, which may provide a novel therapeutic alternative for COPD.
circulation_biomarker_diagnosis_ns	35250259	hsa-mir-221	Concussion, Sports-Related	CONCLUSION: Circulating levels of miR-27a-3p and miR
circulation_biomarker_diagnosis_ns	35250259	hsa-mir-27a	Concussion, Sports-Related	CONCLUSION: Circulating levels of miR-27a-3p and miR
lncRNA target	35249882	hsa-mir-132	Atherosclerosis	CONCLUSION: MiR-132 promotes atherosclerosis by inducing mitochondrial oxidative stress-mediated ferroptosis, which may serve as a promising therapeutic target for AS.
other	35249869	hsa-mir-221	Carcinoma, Hepatocellular	CONCLUSION: Fatty acid metabolism might be one of the most crucial pathways that mediate the effect of the oncomiRNAs in HCC, and the hsa-miR5p/GCDH axis is an important molecular mechanism for HCC progression.
genetics_overexpression_promote	35249453	hsa-mir-193b	Reperfusion Injury, Cerebral Ischemia	Overexpression of SIAH1 partially reversed the protection of miR-193b-3p overexpression against cerebral I/R injury. Overall, overexpression of miR-193b-3p targeted SIAH1 to inhibit the activation of the JNK pathway and protect rats against cerebral I/R injury.
target gene	35249109	hsa-mir-27b	Stomach Neoplasms	Long intergenic non-protein coding RNA 467 inhibition elevates microRNA-27b-3p to repress malignant behaviors of gastric cancer cells via reducing STAT3.
genetics_knock down_promote	35249038	hsa-mir-384	Carcinoma, Renal Cell	Furthermore, a series of rescue experiments showed that miR-384 inhibition reversed the anticancer effects of circ_0037866 knockdown on RCC cells; besides that, miR-384 restoration suppressed RCC cell growth and mobility, which were attenuated by CBX5 overexpression. CONCLUSION: Circ_0037866 knockdown restrains the tumorigenesis of RCC by miR-384/CBX5, revealing a promising molecular target for RCC therapy.
circRNA target	35248826	hsa-mir-326	Cholangiocarcinoma	Functionally, circ_0000591 induced the proliferation, migration and invasion of CCA cells through sponging miR-326. In conclusion, this study revealed a novel regulatory mechanism that circ_0000591 contributed to the progression of CCA via miR-326/TLR4/MyD88/IL6 axis.
other	35248795	hsa-mir-18a	hereditary diffuse gastric cancer	On analyzing the gastric cancer miRNA expression data, FS-DANI identified two miRNAs (hsa-miR-18a* and hsa-miR-381), whose AUCs for distinguishing gastric cancer samples and normal samples are 0.959 and 0.879 in the discovery set and an independent validation set, respectively.
other	35248795	hsa-mir-381	hereditary diffuse gastric cancer	On analyzing the gastric cancer miRNA expression data, FS-DANI identified two miRNAs (hsa-miR-18a* and hsa-miR-381), whose AUCs for distinguishing gastric cancer samples and normal samples are 0.959 and 0.879 in the discovery set and an independent validation set, respectively.
other	35248692	hsa-mir-6506	Pancreatic Carcinoma	Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients.
other	35248692	hsa-mir-944	Pancreatic Carcinoma	Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients.
other	35248692	hsa-mir-136	Pancreatic Carcinoma	Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients.
other	35248692	hsa-mir-570	Pancreatic Carcinoma	Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients.
lncRNA target	35248684	hsa-mir-140	Cognition Disorders	5p inhibits neurogenesis and neuroplasticity via downregulation of Prox1 and aggravates VCI.
lncRNA target	35248684	hsa-mir-140	Cognitive Impairment, Vascular	5p inhibits neurogenesis and neuroplasticity via downregulation of Prox1 and aggravates VCI.
exosome	35248611	hsa-mir-181a	Hair Diseases	The exosomal miR-181a-5p might, therefore, act as the novel biomarker and therapeutic target for treating hair-related diseases and wool production in mammals.
exosome	35248611	hsa-mir-181a	Heart Failure	This study identified a high expression of miR-181a-5p in the low-passage DPC-Exos (exosomes derived from dermal papilla cell), revealing the transportation patterns of the DPC-Exos-derived miR-181a-5p entering the HFSC (hair follicle stem cell).
other	35248525	hsa-mir-29a	Stomach Neoplasms	The gastric cancer (GC) cell line MKN45 was utilized to verify the regulation of KDM5B using the transcription factor (TF) Yin Yang 1 (YY1) and miR-29a-3p.
genetics_GWAS	35248404	hsa-mir-148a	Squamous Cell Carcinoma of Head and Neck	14 base pair Insertion/Deletion polymorphism (rs371194629) and 3142 G/C SNP (rs1063320) of 3'UTR of HLA-G were investigated in conjunction with miR-148A, miR-152 and HLA-G expression in SAB (Spontaneous abortion) history placenta and HNSCC tumor in a hospital-based case control study.
genetics_GWAS	35248404	hsa-mir-152	Squamous Cell Carcinoma of Head and Neck	14 base pair Insertion/Deletion polymorphism (rs371194629) and 3142 G/C SNP (rs1063320) of 3'UTR of HLA-G were investigated in conjunction with miR-148A, miR-152 and HLA-G expression in SAB (Spontaneous abortion) history placenta and HNSCC tumor in a hospital-based case control study.
genetics_overexpression_promote	35248107	hsa-mir-20b	Retinoblastoma	miR-20b-5p downregulation or RRM2 overexpression facilitated RB cell-cycle and proliferation, suppressed apoptosis, and reversed the protective effect of sh-HOTAIR on RB.
lncRNA target	35247910	hsa-mir-183	Breast Neoplasms	Here, we report for the first time the aberrant expression of the putative metastasis suppressing gene SIN3A in human breast cancers and propose a mechanism of SIN3A suppression by miR-183.
other	35247197	hsa-mir-132	Leukemia, Myeloid, Acute	ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy.
other	35247197	hsa-mir-129	Leukemia, Myeloid, Acute	ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy.
other	35247197	hsa-mir-101	Leukemia, Myeloid, Acute	ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy.
other	35247197	hsa-mir-124	Leukemia, Myeloid, Acute	ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy.
other	35247197	hsa-mir-143	Leukemia, Myeloid, Acute	ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy.
genetics_overexpression_promote	35247196	hsa-mir-520a	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Overexpression of miR-520a-3p can target and downregulate the expression of AKT1 to inhibit the invasion and metastasis of NSCLC via suppressing the activation of NF-kappaB signaling pathway.
genetics_knock down_promote	35246517	hsa-mir-335	Adenocarcinoma of Lung	Furthermore, the knockdown of LINC00518 exhibited a synergistic effect with VS6063, an inhibitor of FAK protein, in the suppression of LUAD indicating that miR
circRNA target	35246505	hsa-mir-7682	Pulmonary Fibrosis	In conclusion, we for the first time demonstrated that circRNA_37492 attenuated renal fibrosis via targeting miR3p/Fgb axis, and the homologous hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis, suggesting that circRNA_37492/hsa_circ_0012138 may serve as potent therapy target for obstructive renal fibrosis disease.
circulation_biomarker_diagnosis_down	35246384	hsa-mir-150	Dengue	demonstrated that human microRNA hsa-miR5p is acquired by mosquitoes during blood meals and protects the Dengue virus by downregulation of chymotrypsin AaCT-1 mRNA.
lncRNA target	35246224	hsa-mir-4324	Ovarian Neoplasms	CONCLUSION: Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells.
genetics_GWAS	35246121	hsa-mir-21	Hyperglycemia	CONCLUSIONS: Our findings demonstrated that HI influenced the epigenetic changes related to miR-21 axis, and sustain the concept of reversibility from dysglycemia.
other	35246121	hsa-mir-21	Albuminuria	RESULTS: After HI, we observed a significant reduction of miR-21/ROS/HNE axis in dysglycemic subjects, concomitantly with ameliorating of metabolic parameters, including insulin resistance, BMI, microalbuminuria, reactive hyperemia index and skin fluorescence.
other	35246121	hsa-mir-21	Hyperemia	RESULTS: After HI, we observed a significant reduction of miR-21/ROS/HNE axis in dysglycemic subjects, concomitantly with ameliorating of metabolic parameters, including insulin resistance, BMI, microalbuminuria, reactive hyperemia index and skin fluorescence.
lncRNA target	35246069	hsa-mir-543	Diabetic Nephropathies	CONCLUSIONS: Our study indicate that miR-543 mediates high-glucose induced DN via targeting TSPAN8.
genetics_knock down_promote	35246019	hsa-mir-142	Cicatrix, Hypertrophic	In conclusion, circHECTD1 knockdown interrupts TGF-beta/Smad signaling through miR3p/HMGB1 and suppresses scar fibrosis.
exosome	35246006	hsa-mir-5189	Angelman Syndrome	In conclusion, BMSCs-derived exosomes suppress miR3p to facilitate the apoptosis of FLSs via the BATF2/JAK2/STAT3 signaling pathway, which facilitates the understanding of the therapeutic effect of BMSCs on AS and the underlying molecular mechanism.
exosome	35246006	hsa-mir-5189	Freeman-Sheldon syndrome	In conclusion, BMSCs-derived exosomes suppress miR
other	35245871	hsa-mir-144	Neurodegenerative Diseases	Therefore, TCS acts on GPER to activate the downstream PKC/MAPK signaling pathway, further up-regulating miR-144 expression and causing abnormal modulation of these nerve-related genes to trigger neurodevelopmental toxicity.
transcription factor target	35245628	hsa-mir-150	Cardiac Dysfunction	CONCLUSION: Collectively, LSZ protects Ang II-induced cardiac dysfunction and remodeling via upregulation of miR5p to target MMP14.
other	35244999	hsa-mir-659	Prostatic Hyperplasia	CONCLUSIONS: The expression ratio of urinary miR-H9 to miR-3659 could be a relevant non-invasive biomarker for PCa diagnosis, particularly for patients within the PSA gray zone.
other	35244999	hsa-mir-659	Prostatic Neoplasms	CONCLUSIONS: The expression ratio of urinary miR-H9 to miR-3659 could be a relevant non-invasive biomarker for PCa diagnosis, particularly for patients within the PSA gray zone.
genetics_GWAS	35244769	hsa-mir-1258	Carcinoma, Hepatocellular	Next, we identified transcription factor 7 like 2 (TCF7L2 or TCF4) as a target of miR-1258 and found that Kindlin-2 upregulated TCF4 expression by epigenetically suppressing miR-1258 in HCC.
other	35244768	hsa-mir-345	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
other	35244768	hsa-mir-200c	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
other	35244768	hsa-mir-203	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
other	35244768	hsa-mir-200b	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
other	35244768	hsa-mir-200a	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
other	35244768	hsa-mir-210	Colonic Neoplasms	"RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas."
circulation_biomarker_diagnosis_up	35244512	hsa-mir-509	Pulmonary Arterial Hypertension	5p in serum samples of patients with PAH as well as hypoxia-induced PASMCs was significantly down-regulated, whereas DNMT1 was markedly up-regulated.
genetics_overexpression_promote	35244469	hsa-mir-19b	Carcinoma, Non-Small-Cell Lung	Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies.
genetics_overexpression_promote	35244469	hsa-mir-125b	Carcinoma, Non-Small-Cell Lung	Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies.
genetics_overexpression_promote	35244469	hsa-mir-19a	Carcinoma, Non-Small-Cell Lung	Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies.
genetics_GWAS	35244224	hsa-mir-159	Dehydration	Therefore, our results uncover a new role for the miR159-MYB33-ABI5 module in the regulation of drought response and seed germination in plants.
circulation_biomarker_diagnosis_up	35244069	hsa-mir-28	Atrial Fibrillation	3p levels in plasma/atrial tissue and patients with AF.
genetics_overexpression_suppress	35243940	hsa-mir-498	Melanoma	The overexpression of UBE2T reversed the inhibitory effects of miR-498 on the progression of malignant melanoma cells.
other	35243101	hsa-mir-1269a	Carcinoma, Hepatocellular	Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively.
other	35243101	hsa-mir-199a	Carcinoma, Hepatocellular	Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively.
other	35243101	hsa-mir-182	Carcinoma, Hepatocellular	Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively.
other	35243101	hsa-mir-422a	Carcinoma, Hepatocellular	Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively.
genetics_overexpression_promote	35242856	hsa-mir-6838	Osteosarcoma	Overexpression of circRASSF2 not only promoted the malignant biological behavior of OS cells, but also blocked the anticancer effects of miR
genetics_knock down_promote	35242851	hsa-mir-429	Spinal Cord Injuries	Both the mean of adding exosomes extracted from SCI-patients' plasma and knockdown of miR-429 in the culture of SH-SY5Y cells promoted their apoptosis.
other	35242280	hsa-mir-22	Pain, Inflammatory	Mtf1 signaling axis in the dorsal horn plays a critical role in the induction and maintenance of inflammatory pain.
lncRNA target	35242202	hsa-mir-195	Carcinoma, Endometrioid	CONCLUSIONS: Our research shows the function of sevoflurane in inhibiting the development of endometrial tumors via miRNA
other	35242200	hsa-mir-130b	Carcinoma, Hepatocellular	Moreover, lncRNA MIR17HG/hsa-miRNA-130b-3p/CASP8 regulatory axis in LIHC was also detected.
other	35242200	hsa-mir-17	Carcinoma, Hepatocellular	Moreover, lncRNA MIR17HG/hsa-miRNA-130b-3p/CASP8 regulatory axis in LIHC was also detected.
genetics_overexpression_promote	35242164	hsa-mir-21	Alopecia	Conclusion: These results reveal that overexpression of AC010789.1 suppresses AGA progression via downregulation of hsa-miR5p and TGF-beta1 and promotion of the Wnt/beta-catenin signaling pathway, highlighting a potentially promising strategy for AGA treatment.
circulation_biomarker_diagnosis_down	35242102	hsa-mir-29b	Subarachnoid Hemorrhage	CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR
circulation_biomarker_diagnosis_down	35242102	hsa-mir-142	Subarachnoid Hemorrhage	CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR
circulation_biomarker_diagnosis_down	35242102	hsa-mir-20b	Subarachnoid Hemorrhage	CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR
circulation_biomarker_diagnosis_down	35242102	hsa-mir-590	Subarachnoid Hemorrhage	CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR
circulation_biomarker_diagnosis_down	35242102	hsa-mir-23b	Subarachnoid Hemorrhage	CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR
lncRNA target	35241735	hsa-mir-96	Carcinoma, Renal Cell	These results highlight the direct suppression of PTEN by miR
genetics_overexpression_suppress	35241728	hsa-mir-146a	Respiratory Syncytial Virus Infections	Overexpression of miR-146a targeted down-regulation of TRAF-6 expression and JNK/ERK/MAPK/NF-kappaB pathway induced by RSV infection, reduced the production of inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and alleviate lung injury in young rats.
genetics_overexpression_suppress	35241728	hsa-mir-146a	Lung Injury	Overexpression of miR-146a targeted down-regulation of TRAF-6 expression and JNK/ERK/MAPK/NF-kappaB pathway induced by RSV infection, reduced the production of inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and alleviate lung injury in young rats.
transcription factor target	35241643	hsa-mir-146a	Aging, Premature	This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases.
transcription factor target	35241643	hsa-mir-146a	Aicardi-Goutieres syndrome 5	Furthermore, our results showed that miR-146a impedes the anti-aging effect of AMPK. This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases.
lncRNA target	35241511	hsa-mir-1	Prostatic Neoplasms	MATERIALS AND METHODS: LNCaP or PC3 cells were treated with androgens or transfected with vectors containing microRNA-1 (miR-1), HSP60, HSP60-specific short-hairpin RNA (shHSP60), or a miR-1 inhibitor.
exosome	35241153	hsa-mir-100	Hemorrhage	Mechanistically, our data suggested that SHED-Exos are enriched with miR5p and miR-1246 and are transferred to endothelial cells, which results in decreased tube formation via the down-regulation of VEGFA expression.
exosome	35241153	hsa-mir-1246	Hemorrhage	Mechanistically, our data suggested that SHED-Exos are enriched with miR5p and miR-1246 and are transferred to endothelial cells, which results in decreased tube formation via the down-regulation of VEGFA expression.
other	35241117	hsa-mir-17	Urinary Bladder Neoplasms	The pairs of miR5p (upregulated in BLCA tissues) and TGFBR2 (downregulated in BLCA tissues) were verified in the external validation cohort (28 BLCA vs.
genetics_overexpression_promote	35241106	hsa-mir-500a	Colorectal Neoplasms	Overexpression of CDK6 phenotypically rescued the inhibitory effect of miR-500a-3p on the proliferation and glycolysis of CRC cells.
lncRNA target	35241028	hsa-mir-873	Esophageal Squamous Cell Carcinoma	CONCLUSION: These findings unraveled that hsa_circ_0000277 promoted ESCC progression and DDP resistance via miR
exosome	35240953	hsa-mir-29a	Cardiomegaly	Studies have reported an important role for miR-29a in regulating angiogenesis and pathological myocardial hypertrophy. However, whether CMderived exosomal miR-29a is involved in regulating cardiac microvascular endothelial cell (CMEC) homeostasis during myocardial hypertrophy has not been determined.
lncRNA target	35240924	hsa-mir-4311	Squamous Cell Carcinoma of Head and Neck	Our study provides evidence that LINC00472 plays an essential role in inhibiting oral squamous cell carcinoma progression and affecting immune responses by directly binding to hsa-miR-4311 to regulate the expression of GNG7 positively.
lncRNA target	35240920	hsa-mir-146a	Stomach Neoplasms	Altogether, HCG18 promotes GC progression via the miR-146a-5p/TRAF6 axis and could be a GC treatment target.
circRNA target	35240495	hsa-mir-296	Breast Neoplasms	In conclusion, the tumor-promoting role of circ_002172 in BC was achieved by inducing immune escape via the miR
genetics_knock down_promote	35240453	hsa-mir-149	Uterine Cervical Neoplasms	5p overexpression on angiogenesis and malignant behaviors of CC cells.
transcription factor target	35240295	hsa-mir-190	Autoimmune Diseases	Collectively, these results provide strong evidence for an important regulatory mechanism of miR-103 and miR-190 targeting the IL-1R1 gene, thereby preventing excessive inflammatory immune responses from causing autoimmunity.
transcription factor target	35240295	hsa-mir-103	Autoimmune Diseases	Collectively, these results provide strong evidence for an important regulatory mechanism of miR-103 and miR-190 targeting the IL-1R1 gene, thereby preventing excessive inflammatory immune responses from causing autoimmunity.
other	35240232	hsa-mir-193b	Colorectal Neoplasms	Among the miRNAs regulated by TRF2, we focused on miR-193b-3p, an oncomiRNA that positively correlates with TRF2 expression in human colorectal cancer patients from The Cancer Genome Atlas dataset.
other	35240034	hsa-mir-155	Myocarditis	Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590.
other	35240034	hsa-mir-221	Myocarditis	Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590.
other	35240034	hsa-mir-10a	Myocarditis	Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590.
transcription factor target	35239776	hsa-mir-23a	Sepsis	Upregulation of miR-23a-3p may alleviate LPS-induced cell injury by targeting wnt5a and inactivating Wnt/beta-catenin pathway, which may serve as a novel therapeutic target for sepsis-associated AKI.
circulation_biomarker_diagnosis_ns	35239506	hsa-mir-382	Renal Insufficiency, Chronic	Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum.
circulation_biomarker_diagnosis_ns	35239506	hsa-mir-146	Renal Insufficiency, Chronic	Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum.
circulation_biomarker_diagnosis_ns	35239506	hsa-mir-21	Renal Insufficiency, Chronic	Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum.
circulation_biomarker_diagnosis_ns	35239506	hsa-mir-199	Renal Insufficiency, Chronic	Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum.
circulation_biomarker_diagnosis_ns	35239506	hsa-mir-235	Renal Insufficiency, Chronic	Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum.
target gene	35239148	hsa-mir-25	Esophageal Neoplasms	Mir-25 Promotes Metastasis of Esophageal Cancer by Targeting BTG2.
genetics_overexpression_promote	35239093	hsa-mir-656	Nasopharyngeal Carcinoma	3p overexpression restrained NPC cell malignant phenotypes, while ELF2 elevation reversed the effects.
circRNA target	35239092	hsa-mir-876	Carcinoma, Non-Small-Cell Lung	Circ_0016760 could promote the malignant development of NSCLC through miR
lncRNA target	35239064	hsa-mir-758	Breast Neoplasms	In conclusion, circ_0008500 inhibition promoted the radiosensitivity and restrained the development of breast cancer by downregulating PFN2 expression via targeting miR
lncRNA target	35238915	hsa-mir-466b	Leukoencephalopathies	We conclude that miR-466b-5p is involved in the regulation of WMI pathogenesis, partly through the Lpar1/Edg2/Sox10 and Lpar1/Edg2/PLP signaling pathways.
other	35238896	hsa-mir-558	Gestational Trophoblastic Disease	Circ_0007611 aggravated trophoblast cell disorders by the miR-558/IL1RAP pathway in PE.
other	35238896	hsa-mir-558	Pneumonia, Mycoplasma	Circ_0007611 and IL1RAP expressions were significantly upregulated, while miR-558 was downregulated in the placental tissues of PE women in comparison with normal placental tissues. Circ_0007611 aggravated trophoblast cell disorders by the miR-558/IL1RAP pathway in PE.
lncRNA target	35238350	hsa-let-7f	Atherosclerosis	Here, we investigated the role of let-7f in hMSC tropism to human atheromas and the effects of the plaque microenvironment on cell fate and release of soluble factors. CONCLUSIONS: Our findings indicate that let-7f promotes hMSC tropism towards atheromas through the LL-37/FPR2 axis and demonstrate that hMSCs upon contact with human plaque environment develop a potentially athero-protective signature impacting the pathophysiology of atherosclerosis.
other	35238312	hsa-mir-1276	Aortic Valve Stenosis	CONCLUSIONS: Our analysis suggested that IBSP, NCAM1, MMP9, FCGR3B, COL4A3, FCGR1A, THY1, RUNX2, ITGA4, and COL10A1 might be hub genes associated with AS, and hsa-miR-1276 was potential miRNA.
other	35238277	hsa-mir-340	Pancreatitis	5p to promote HMGB1 expression, which activates TLR4 expression and promotes myocardial injury in rats with SAP.
other	35238277	hsa-mir-340	Cardiomyopathies	5p to promote HMGB1 expression, which activates TLR4 expression and promotes myocardial injury in rats with SAP.
lncRNA target	35238066	hsa-mir-411	Prostatic Neoplasms	5p directly targeted PGK1, and miR
genetics_knock down_promote	35238054	hsa-mir-497	Prostatic Neoplasms	In conclusion, TRPM2-AS knockdown suppressed cell progression and PTX resistance in PTX-resistant PCa cells by miR
circulation_biomarker_prognosis_ns	35237856	hsa-mir-200a	Breast Neoplasms	Our results encourage the use of circulating miR-200s as valuable prognostic biomarkers during metastatic breast cancer therapy.
lncRNA target	35237695	hsa-mir-582	Carcinoma, Hepatocellular	CONCLUSION: TUG1 increases the Siglec-15 level in HCC cells as a sponge to hsa-miR5p, resulting in enhanced immunosuppression.
circulation_biomarker_diagnosis_ns	35237654	hsa-mir-106a	Ischemic Stroke	At the same time, we found marked increases of serum TUG1, LINC00657, and miR-9 and a marked decrease of serum miR-106a in diabetic patients who had stroke relative to those without stroke.
circulation_biomarker_diagnosis_ns	35237654	hsa-mir-106a	Diabetes Mellitus, Type 2	At the same time, we found marked increases of serum TUG1, LINC00657, and miR-9 and a marked decrease of serum miR-106a in diabetic patients who had stroke relative to those without stroke.
lncRNA target	35237522	hsa-mir-493	Esophageal Squamous Cell Carcinoma	Using bioinformatics tools, we saw miR5p as the direct molecular target of LINC00324 and interacted with the MAPK signaling pathway in ESCC pathogenesis.
transcription factor target	35237382	hsa-mir-672	Spinal Cord Injuries	These results indicated that sh-miR3p exerted a neural restoration effect in vivo and in vitro by inhibiting ferroptosis via the FSP1 pathway.
lncRNA target	35237322	hsa-mir-200	Carcinoma, Hepatocellular	CONCLUSION: Our study showed meloxicam inhibited HCC progression and enhanced the sensitivity of immunotherapy via the microRNA-200/PD-L1 pathway.
genetics_knock down_promote	35237319	hsa-mir-766	Prostatic Neoplasms	5p inhibition largely restores NEAT1 downregulation-mediated function on PCa progression, while E2F3 knockdown partly removes the effects of miRNA
other	35237223	hsa-mir-24	Friedreich Ataxia	3p-CD28 may be the potential RNA regulatory pathway related to the pathogenesis of child and adult FRDA.
other	35237086	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	5p, and miR-21) for the detection of TSCC was confirmed.
other	35237086	hsa-mir-139	Squamous Cell Carcinoma of Head and Neck	5p, and miR-21) for the detection of TSCC was confirmed.
other	35237086	hsa-mir-486	Squamous Cell Carcinoma of Head and Neck	5p, and miR-21) for the detection of TSCC was confirmed.
genetics_overexpression_promote	35236936	hsa-mir-10b	Carcinoma, Hepatocellular	RESULTS: Sorafenib-induced apoptosis in HCC cells was significantly enhanced by miR-10b-3p overexpression and partially abrogated by miR-10b-3p depletion.
lncRNA target	35236826	hsa-mir-183	Carcinoma, Hepatocellular	Collectively, our findings suggest the crucial role of the miR5p.1/MUC15/c-MET/PI3K/AKT/SOX2 regulatory circuit in regulating liver T-ICs properties, suggesting potential therapeutic targets for HCC.
genetics_knock down_promote	35236654	hsa-mir-127	Ovarian Neoplasms	3p could restore the effects of mifepristone on the proliferation and apoptosis of SKOV3 cells and A2780 cells, as well as the expression of PD-L1, CyclinD1, Cl-caspase-3 and Bax protein; our study confirmed that mifepristone can regulate the expression of VAMP2 and PD-L1 through miR
circulation_biomarker_diagnosis_ns	35236644	hsa-mir-148a	Endometriosis	The expression of miR-148a in serum of EMS patients was decreased, and miR-148a targets ADAMTS5 to promote apoptosis in EMS cells.
genetics_overexpression_promote	35236339	hsa-mir-140	Diabetes Mellitus	3p overexpressed-Exos accelerated diabetic wound healing by promoting the osteoblastogenesis function of BMSCs through inhibition plexin B1 expression which is the receptor of Sema4D and the plexin B1/RhoA/ROCK pathway compared with diabetes mellitus-Exos.
genetics_overexpression_promote	35236289	hsa-mir-152	Carcinoma, Hepatocellular	3p mimics were counteracted by overexpression of ROBO1 in HCC cells.
lncRNA target	35236255	hsa-mir-137	Intervertebral Disc Degeneration	This study aimed to investigate the role played by microRNA (miR)-137 in intervertebral disc degeneration via targeting activin A receptor type I (ACVR1) and the underlying mechanism.
genetics_knock down_promote	35236250	hsa-mir-134	Squamous Cell Carcinoma of Head and Neck	In addition, knockdown of EGFR or overexpression of miR
lncRNA target	35236239	hsa-mir-136	Dehydration	This research aims to explore whether Res inhibits miR5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ).
transcription factor target	35235816	hsa-mir-200c	Breast Neoplasms	The purpose of this paper is to examine the outcome of miR-200c restoring on enhancing the BC cells' sensitivity to Doxorubicin through downregulating the MDR1 expression.
other	35235759	hsa-mir-144	Heart Failure	In addition, hsa-miR3p and CCNE2 may be considered as potential diagnostic gene biomarkers in HF.
other	35235759	hsa-mir-144	Cardiomyopathies	In addition, hsa-miR3p and CCNE2 may be considered as potential diagnostic gene biomarkers in HF.
lncRNA target	35235755	hsa-mir-335	Atherosclerosis	Herein, it appears that the LncRNA DANCR was closely associated with the progression of atherosclerosis by targeting miR5p, which might be a potential detective predictor and target for the treatment of atherosclerosis.
genetics_overexpression_promote	35235752	hsa-mir-940	Stomach Neoplasms	5p were overexpressed in GA, while mature miR
genetics_overexpression_suppress	35235474	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	5p was significantly overexpressed in HNSCC compared to healthy tissues (P < .05) and showed potent predictive power with a summary receiver operating characteristic of 0.90.
lncRNA target	35235468	hsa-mir-21	Wounds and Injuries	By investigating the healing mechanism, it was found that CPPM increased the hydroxyproline content in granulation tissue and had an excellent antioxidant ability, and then inhibited lipid peroxidation, in addition, it significantly increased the transcript levels of VEGF and miRNA-21 genes, indicating that CPPM play an influential role in vascular remodeling during wound healing by up-regulating the expression of VEGF and miRNA-21 genes.
other	35235435	hsa-let-7	Memory Disorders	The LPS group also showed an increase in the inflammatory markers tumor necrosis factor-alpha and nuclear factor kappa B and downregulation of miR-146a and miR-let 7 expressions in the brain cells compared to the normal group, P value <.05.
other	35235435	hsa-let-7	Neurogenic Inflammation	The LPS group also showed an increase in the inflammatory markers tumor necrosis factor-alpha and nuclear factor kappa B and downregulation of miR-146a and miR-let 7 expressions in the brain cells compared to the normal group, P value <.05.
genetics_overexpression_suppress	35235424	hsa-mir-195	Wounds and Injuries	Decreased ARP-2 levels by miR-195 overexpression were associated with an inhibition of early epithelial restitution, as indicated by a decrease in cell migration over the wounded area.
genetics_overexpression_promote	35235236	hsa-mir-654	Breast Neoplasms	5p, resulting in overexpression of MEF2D in BCSCs.
circRNA target	35235125	hsa-mir-532	Uterine Cervical Neoplasms	The circWHSC1-mediated miR3p/LTBP2 signaling axis might be a novel therapeutic target for CaCx.
lncRNA target	35234989	hsa-mir-136	Triple Negative Breast Neoplasms	Si-circPTK2, mimic and inhibitor of miR-136 were transfected in TNBC cells to confirm the mechanism of circPTK2 and miR-136 in TNBC cells.
other	35234284	hsa-mir-203b	Obesity	miRNA-mRNA pairing analysis identified an association between 4 miRNAs (miR-759, miR-9a-3p, miR-203b-3p, and miR-878) that were differentially expressed in the obesity and control groups and 7 genes (Ly86, Arid5b, Rgs18, Mlana, P2ry13, Kif1b, and Myt1) expressed in gingival tissue.
other	35234284	hsa-mir-9a	Obesity	miRNA-mRNA pairing analysis identified an association between 4 miRNAs (miR-759, miR-9a-3p, miR-203b-3p, and miR-878) that were differentially expressed in the obesity and control groups and 7 genes (Ly86, Arid5b, Rgs18, Mlana, P2ry13, Kif1b, and Myt1) expressed in gingival tissue.
genetics_overexpression_suppress	35234260	hsa-mir-374c	Carcinoma, Hepatocellular	In vivo, it was found that overexpression of miR374c5p significantly inhibited the growth and proliferation of HCC cells.
circulation_biomarker_diagnosis_ns	35234251	hsa-mir-885	Liver Diseases	Specifically, the authors profiled circulating miRNAs in patients with hepatocellular carcinoma (HCC), liver cirrhosis (LC), and healthy controls and found that serum miR5p levels were significantly higher in samples of patients with HCC (6.5-fold increase) and LC (8.8-fold increase).
genetics_overexpression_promote	35234205	hsa-mir-130a	Sepsis-Associated Encephalopathy	Results: Here our results described that YY1 and TREM-2 were downregulated and miR-130a-3p was upregulated in SAE. Conclusion: Taken together, YY1 promoted microglia M2 polarization via upregulating TREM-2 by interacting with miR-130a-3p promoter, suggesting YY1 overexpression might be a novel therapeutic strategy of SAE.
lncRNA target	35233882	hsa-mir-147a	Uterine Cervical Neoplasms	CONCLUSION: LncRNA OIP5-AS1 promotes the migration, invasion and EMT of cervical cancer cells via targeting miR-147a/IGF1R pathway.
genetics_knock down_promote	35233464	hsa-mir-206	Stomach Neoplasms	CONCLUSION: circ_AKT3 knockdown suppressed cisplatin resistance using miR-206/PTPN14 axis in cisplatin-resistant GC cells.
genetics_overexpression_promote	35233463	hsa-mir-4673	Pancreatic Carcinoma	The overexpression of SLCO4A1-AS1 aggravated the malignant behaviors of PC via the upregulation of KIF21B by sponging miR-4673.
circulation_biomarker_diagnosis_ns	35232961	hsa-mir-486	Pulmonary Disease, Chronic Obstructive	The combination of plasma miR
other	35232557	hsa-mir-153	Diabetic Nephropathies	3p was lower in diabetic nephropathy patients, while the expression of PAQR3 was concomitantly higher.
genetics_overexpression_promote	35232010	hsa-mir-151	Glioma	Additionally, overexpression of miR-151 also suppressed the migration and invasion of the human glioma cells.
other	35231919	hsa-mir-17	Carcinoma, Transitional Cell	5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs.
other	35231919	hsa-mir-224	Carcinoma, Transitional Cell	5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs.
other	35231919	hsa-mir-145	Carcinoma, Transitional Cell	5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs.
circulation_biomarker_diagnosis_ns	35231918	hsa-mir-338	psoriasis 1	5p was highly expressed in the clinical serum samples from psoriasis patients.
lncRNA target	35231647	hsa-mir-183	Adenomyosis	CONCLUSION: In general, we are the first to disclose the distinction of miR-183 and MMP-9 expressions in adenomyosis after we elucidated miR-183's role in epithelium's viability, migration and invasion .
other	35231462	hsa-mir-9	Neurotoxicity Syndromes	Here, RSV was found to upregulate miR5p expression and downregulate MeHg-induced neurotoxicity, thereby minimizing cytotoxicity in primary hippocampal neurons and effectively attenuating MeHg-induced neurotoxicity.
genetics_overexpression_suppress	35231441	hsa-mir-125	Intervertebral disc disease	5p was low expression, while SUV39H1 was overexpressed in IDD.
other	35231061	hsa-mir-590	Myocardial Infarction, Acute	By searching the literature in PubMed, we concluded that AQP9, IL1B, and IL1RN could be used as gene markers for AMI, while FSTL3-miR3303p-IL1B/IL1RN and ACSL4-miR5905p-IL1B could be used as RNA regulatory pathways affecting AMI disease progression.
circRNA target	35230926	hsa-mir-1200	Colonic Neoplasms	In conclusion, circRNA_0085315 serves as a ceRNA and promotes CC progression through the activation of the MAPK signaling pathway mediated via the miR-1200/MAP3K1 axis, suggesting that circRNA_0085315 may be a promising diagnostic and therapeutic target for CC.
genetics_knock down_promote	35230916	hsa-mir-615	Fibrosis, Renal	This study demonstrated that the overexpression of lncRNA4474 may attenuate fibrosis progression, accompanied by the downregulation of miR-615 and upregulation of HNF-1beta.
lncRNA target	35230909	hsa-mir-27b	Ovarian Neoplasms	LINC01234 regulates miR-27b-5p to induce the migration, invasion and self-renewal of OCSCs through targeting SIRT5.
circulation_biomarker_diagnosis_down	35230891	hsa-mir-501	Sepsis	5p expression was down-regulated in peripheral blood samples of septic patients with cardiac dysfunction, lipopolysaccharide (LPS)-induced cardiomyocytes, and the myocardium and peripheral blood in the septic model.
other	35230810	hsa-mir-141	Prostatic Neoplasms	In this work, a new electrochemiluminescence (ECL) platform was constructed for detecting the prostate cancer marker microRNA-141 (miRNA-141) on a constant resistor-integrated closed bipolar electrode (BPE).
lncRNA target	35230201	hsa-mir-942	Carcinoma, Non-Small-Cell Lung	circPTK2 (hsa_circ_0008305) and TRIM16 were low expressed, while miR-942 was significantly highly expressed in NSCLC tissues and cell lines. Furthermore, circPTK2 weakened CDDP resistance of NSCLC through modulating miR-942/TRIM16 axis, providing a novel sight for the treatment of NSCLC and improving the understanding of the CDDP resistance mechanism of NSCLC.
other	35230198	hsa-mir-197	Lung Neoplasms	3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma.
other	35230198	hsa-mir-375	Lung Neoplasms	3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma.
exosome	35229987	hsa-mir-122	osteogenesis imperfecta type 1	miRNA-seq found that exosomal miR
lncRNA target	35229638	hsa-mir-223	COVID-19	These results confirmed the contribution of miRNA-223 to the regulation of SARS-CoV-induced pathogenic processes and support the therapeutic potential of inhibiting miRNAs during coronavirus infection using RNA interference approaches.
lncRNA target	35229638	hsa-mir-223	Acute Kidney Injury	These results confirmed the contribution of miRNA-223 to the regulation of SARS-CoV-induced pathogenic processes and support the therapeutic potential of inhibiting miRNAs during coronavirus infection using RNA interference approaches.
circulation_biomarker_diagnosis_ns	35229538	hsa-mir-143	Aortopathies	Further, the multivariate logistic regression analysis revealed an association between blood and aortic tissue miR-143 levels each other (Odds Ratio [OR] 1.29, 95% Confidence Interval [CI] 1.11-1.67, p = 0.02; OR 1.36, 95% CI 1.19-2.01, p = 0.03, respectively) and a blood/aortic miR-143 level to dilated aorta (OR 3.61, 95% CI 1.62-9.02, p = 0.01; OR 2.92, 95% CI 1.81-7.05, p = 0.02, respectively).
circulation_biomarker_diagnosis_ns	35229538	hsa-mir-1	Aortopathies	Further, the multivariate logistic regression analysis revealed an association between blood and aortic tissue miR-143 levels each other (Odds Ratio [OR] 1.29, 95% Confidence Interval [CI] 1.11-1.67, p = 0.02; OR 1.36, 95% CI 1.19-2.01, p = 0.03, respectively) and a blood/aortic miR-143 level to dilated aorta (OR 3.61, 95% CI 1.62-9.02, p = 0.01; OR 2.92, 95% CI 1.81-7.05, p = 0.02, respectively).
other	35229372	hsa-let-7c	Colorectal Neoplasms	Expressions of miRNA, miR-200a and let-7c were significantly higher in adenomas than normal tissues (p = .008 and p = .045 respectively).
other	35229372	hsa-mir-200a	Colorectal Neoplasms	Expressions of miRNA, miR-200a and let-7c were significantly higher in adenomas than normal tissues (p = .008 and p = .045 respectively).
genetics_knock down_suppress	35229272	hsa-mir-1306	Alzheimer Disease	CircAXL knockdown alleviates Abeta(1-42)-induced neurotoxicity in AD pathology via repressing PDE4A by releasing miR
genetics_overexpression_promote	35229031	hsa-mir-876	Nasopharyngeal Carcinoma	5p overexpression or NETO2 downregulation had inhibitory effects on cell proliferation, migration, and invasion in NPC.
exosome	35229026	hsa-mir-1294	Carcinoma, Non-Small-Cell Lung	Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis.
transcription factor target	35228896	hsa-mir-141	Colorectal Neoplasms	Our study indicates that ANG regulates CRC progression by disrupting miR-141 and its regulation on angiogenesis-related target genes, not only revealing a new mechanism of ANG action but also newly identifying miR-141 as a substrate of ANG.
circulation_biomarker_diagnosis_ns	35228564	hsa-mir-126	ST Elevation Myocardial Infarction	Plasma miR-30e can indicate the risk of no-reflow during primary percutaneous coronary intervention (pPCI), while miR-126 can be used as a predictor of coronary slow flow phenomenon.
circulation_biomarker_diagnosis_up	35228564	hsa-mir-155	ST Elevation Myocardial Infarction	Elevated MALAT1, CRP, HPSE, and EDN1 expression and suppressed miR-30e, miR-155 and miR-126 expression was found in the plasma of STEMI patients receiving pPCI who were diagnosed with no-reflow phenomenon.
lncRNA target	35228520	hsa-mir-32	Prostatic Neoplasms	In conclusion, we show that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR
exosome	35228162	hsa-mir-1287	Carcinoma, Non-Small-Cell Lung	Exosome circ_0048856 promoted the NSCLC development by targeting miR
circRNA target	35227787	hsa-mir-339	Prostatic Neoplasms	5p/STAT5A axis, and it may function as a potential prognostic biomarker or therapeutic target for PCa treatment.
genetics_overexpression_suppress	35227681	hsa-mir-340	Squamous Cell Carcinoma of Head and Neck	3p overexpression inhibited while down-regulation of miR
other	35227173	hsa-mir-106a	Nasopharyngeal Carcinoma	In addition, downregulation of microRNA 106a-5p (miR-106a-5p) expression and upregulation of SRY-box transcription factor 4 (SOX4) expression were observed in DDP-resistant NPC tissues and cells. In summary, HOTAIR enhanced DDP resistance in NPC cells by regulating the miR-106a-5p/SOX4 axis.
genetics_GWAS	35227165	hsa-mir-146a	COVID-19	Then, miRNA-146a rs2910164 GC single-nucleotide polymorphism (SNP) was genotyped in a larger group of COVID-19 patients (n = 129), and its relationship with severe disease [Intensive Care Unit (ICU) support or survival/death] was assessed.
lncRNA target	35226830	hsa-mir-200b	Stomach Neoplasms	In conclusion, miR-200b-3p inhibited GC progression via regulating CXCL12/CXCR7 axis.
circulation_biomarker_diagnosis_up	35226820	hsa-mir-29b	Sjogren's Syndrome	Our results revealed that KCNQ1OT1 was downregulated while miR-29b-3p was upregulated in the serum samples of OM patients, as well as in SpA-infected hBMSCs.
circulation_biomarker_diagnosis_up	35226820	hsa-mir-29b	Otitis Media	We first examined the expression of lncRNA KCNQ1OT1 and miR-29b-3p in the serum samples of OM patients and healthy controls. Our results revealed that KCNQ1OT1 was downregulated while miR-29b-3p was upregulated in the serum samples of OM patients, as well as in SpA-infected hBMSCs.
other	35226820	hsa-mir-29b	Pneumonia, Staphylococcal	In the present study, we investigated the role of KCNQ1OT1/miR-29b-3p axis in osteogenic differentiation in staphylococcus aureus (SpA)-infected human bone mesenchymal stem cells (hBMSCs).
other	35226820	hsa-mir-29b	Bone Diseases	In the present study, we investigated the role of KCNQ1OT1/miR-29b-3p axis in osteogenic differentiation in staphylococcus aureus (SpA)-infected human bone mesenchymal stem cells (hBMSCs).
circulation_biomarker_diagnosis_ns	35226566	hsa-mir-199a	Plaque, Atherosclerotic	Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR
other	35226566	hsa-mir-93	Plaque, Atherosclerotic	Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden.
circulation_biomarker_diagnosis_ns	35226566	hsa-mir-222	Plaque, Atherosclerotic	Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR
other	35226566	hsa-mir-451a	Plaque, Atherosclerotic	Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden.
circulation_biomarker_diagnosis_ns	35226566	hsa-mir-221	Plaque, Atherosclerotic	Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR
other	35226566	hsa-mir-15a	Plaque, Atherosclerotic	Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden.
circulation_biomarker_diagnosis_ns	35226566	hsa-mir-92a	Plaque, Atherosclerotic	Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR
transcription factor target	35226449	hsa-mir-139	Kidney Neoplasms	The expression of miR-139 was found to be significantly (P<0.05) downregulated in human kidney cancer cells lines. Taken together, the results revealed that CXCR/miR-139 axis regulates the proliferation, migration, and invasion of human kidney cancer cells and may act as a therapeutic target.
other	35226160	hsa-mir-383	Polycystic Ovary Syndrome	5p had sufficient potential for prediction of PCOS.
other	35225755	hsa-mir-613	Osteoarthritis	Collectively, circ_0020014 acted as a miR-613 sponge to regulate ADAMTS5 expression, thereby protecting chondrocytes from IL-1beta-induced inflammatory damage, which might be a novel diagnostic marker for OA.
genetics_knock down_promote	35225648	hsa-mir-193a	Lung Neoplasms	And IRF4 overexpression reversed miR-193a-3p mimic-mediated effects on NSCLC cell malignancy, autophagy, and glycolysis.
genetics_knock down_promote	35225648	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	And IRF4 overexpression reversed miR-193a-3p mimic-mediated effects on NSCLC cell malignancy, autophagy, and glycolysis.
genetics_overexpression_promote	35225486	hsa-mir-92a	Colorectal Neoplasms	RESULTS: Statistically significant overexpression of serum miR-92a was observed in CRC patients as compared to adenoma and control groups (p&lt;0.001 each) and lower serum Bim in CRC patients as compared to adenoma and control groups (p=0.001, p &lt;0.001 respectively).
lncRNA target	35224785	hsa-mir-940	Carcinoma, Hepatocellular	LncRNA THEMIS2-211 exerts its biological function as an oncogene that promotes the proliferation, migration, invasion, EMT of HCC cells by physically interacting with miR-940 and therefore promoting SPOCK1 expressions. The discovery of lncRNA THEMIS2-211 further illuminates the molecular pathogenesis of HCC and the THEMIS2-211/miR-940/SPOCK1 axis may act as a potential therapeutic target for HCC.
other	35224615	hsa-mir-144	Diabetes, Gestational	In those regulatory axes, the MALAT1/hsa-miR3p/IRS1 axis was predicted to be the key axis and was identified as being associated with GDM for the first time.
other	35224317	hsa-mir-122	Liver Cirrhosis	The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis.
other	35224317	hsa-mir-150	Carcinoma, Hepatocellular	The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis.
other	35224317	hsa-mir-150	Liver Cirrhosis	The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis.
other	35224317	hsa-mir-122	Carcinoma, Hepatocellular	The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis.
target gene	35224289	hsa-mir-19b	Lung Neoplasms	Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis.
other	35223986	hsa-mir-106b	Squamous Cell Carcinoma of Head and Neck	Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC).
other	35223986	hsa-mir-196b	Squamous Cell Carcinoma of Head and Neck	Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC).
circulation_biomarker_diagnosis_ns	35223564	hsa-mir-21	Asthma	BACKGROUND: This research was designed to probe into the role of miRNA-21 in the pathogenesis of childhood asthma and its correlation with the severity. RESULTS: Compared with that of healthy children, the miR-21 expression in peripheral blood serum of asthmatic children was higher (P<0.001).
transcription factor target	35223454	hsa-mir-100	Urinary Bladder Neoplasms	5p in BC, that might represent not only a useful biomarker for improved diagnosis and patients' stratification but also as a promising axis that might be therapeutically targeted in situ.
transcription factor target	35223454	hsa-mir-138	Urinary Bladder Neoplasms	5p in BC, that might represent not only a useful biomarker for improved diagnosis and patients' stratification but also as a promising axis that might be therapeutically targeted in situ.
genetics_overexpression_suppress	35223452	hsa-mir-22	Carcinoma, Mucoepidermoid	Two overexpressed miRNAs in MEC (miR-22 and miR-205) were selected for inhibition by the CRISPR-Cas9 method.
genetics_overexpression_suppress	35223452	hsa-mir-205	Carcinoma, Mucoepidermoid	Two overexpressed miRNAs in MEC (miR-22 and miR-205) were selected for inhibition by the CRISPR-Cas9 method.
other	35223094	hsa-mir-197	Sepsis	Studies have found that miR-197 is correlated with the prognosis of patients with inflammatory heart disease, but its effect on sepsis-induced cardiomyocyte injury remains unclear. miR-197 contributed to LPS-induced cardiomyocyte injury by modulating SIRT1, which might be used as a molecular marker in the management of sepsis.
other	35223094	hsa-mir-197	Myocarditis	Studies have found that miR-197 is correlated with the prognosis of patients with inflammatory heart disease, but its effect on sepsis-induced cardiomyocyte injury remains unclear.
other	35223093	hsa-mir-654	Coronary Artery Disease	5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2).
other	35223093	hsa-mir-411	Coronary Artery Disease	5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2).
other	35223093	hsa-mir-136	Coronary Artery Disease	5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2).
other	35223093	hsa-mir-376c	Coronary Artery Disease	5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2).
lncRNA target	35222878	hsa-mir-146a	Pancreatic Carcinoma	In summary, we found miR-146a reduced the cell proliferation of pancreatic cancer through targeting SOX7.
other	35222845	hsa-mir-142	Prostatic Neoplasms	3p in PC samples with GS 9.
other	35222845	hsa-mir-296	Prostatic Neoplasms	3p in PC samples with GS 9.
other	35222845	hsa-mir-155	Prostatic Neoplasms	3p in PC samples with GS 9.
lncRNA target	35222806	hsa-mir-155	Hypoxia-Ischemia, Brain	5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI.
lncRNA target	35222806	hsa-mir-155	Inflammation	5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI.
lncRNA target	35222806	hsa-mir-15	Hypoxia-Ischemia, Brain	5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI.
lncRNA target	35222806	hsa-mir-15	Inflammation	5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI.
transcription factor target	35222797	hsa-mir-483	Hypertension	These findings suggest that miR3p exerts a protective effect on EC function during the onset of hypertension and thus may be considered a potential therapeutic target for hypertension-related cardiovascular diseases.
lncRNA target	35222741	hsa-mir-24	Coronary Artery Disease	CONCLUSIONS: LINC00460 regulates the proliferative ability of ECs and thus the occurrence and development of coronary atherosclerotic diseases by targeting miRNA3p.
lncRNA target	35222723	hsa-mir-425	Squamous Cell Carcinoma of Head and Neck	Collectively, the findings of the present study demonstrated that lncRNA HCG22 may inhibit the proliferation, invasion and migration of OSCC cells by downregulating miR
target gene	35222721	hsa-mir-455	Colorectal Neoplasms	Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p.
other	35222718	hsa-mir-615	Alzheimer Disease	3p may be potential biomarkers in the early diagnosis of AD.
lncRNA target	35222713	hsa-mir-9	Diabetic Nephropathies	At the molecular level, TUG1 was revealed to promote sirtuin 1 (SIRT1) expression by sponging microRNA (miR)-9, and SIRT1 OE reversed the HG-induced apoptosis and mitochondrial dysfunction increased by TUG1 KD. The present data indicated that downregulation of TUG1 induced by HG was associated with HG-induced apoptosis and mitochondrial dysfunction in podocytes, and that TUG1 protected HG-induced podocytes by promoting SIRT1 expression via miR-9 inhibition.
target gene	35222708	hsa-mir-146b	Colorectal Neoplasms	miR-146b-5p promotes colorectal cancer progression by targeting TRAF6.
other	35222688	hsa-mir-16	Multiple Myeloma	After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05).
other	35222688	hsa-mir-21	Multiple Myeloma	After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05).
other	35222688	hsa-mir-15a	Multiple Myeloma	After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05).
target gene	35222643	hsa-mir-524	Carcinoma, Non-Small-Cell Lung	EGFR-AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR-524-5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal Degradation.
lncRNA target	35222538	hsa-mir-466	Myocardial Infarction	Mirt1 acts as a ceRNA to bind to miR-466i-5p to further regulate the expression levels of the target gene, thereby aggravating cardiac remodeling after MI.
other	35222538	hsa-mir-466	Ichthyosis, Lamellar	Co-expression network analysis identified two core lncRNAs (Mirt1 and AC125351.1) and two core microRNAs (miR-466i-5p and miR5p) during the development of CIH-exaggerated post-MI remodeling, and they were verified by quantitative real-time PCR (qRT-PCR).
exosome	35222263	hsa-mir-26b	Polycystic Ovary Syndrome	The study indicates that adipose tissue-derived extracellular vesicles-miR-26b may play a key role in the PCOS and also provides insight into developing new therapeutic strategies for PCOS.
lncRNA target	35222075	hsa-mir-122	Inflammation	This study provides a novel finding that FOXO3 was the target gene of miR
lncRNA target	35222033	hsa-mir-21	Lipid Metabolism Disorders	Inhibition of miR-21 expression or Fenofibrate (PPARalpha agonist) administration prevented the decrease of PPARalpha in renal tubular epithelial cells under high glucose (HG) and high fat (Palmitic acid, PA) conditions, alleviating lipid metabolism disorders and reducing mitochondrial dynamics and inflammation. Based on these observations, we conclude that Atorvastatin inhibits tubular epithelial cell injury in T1DM with concomitant induction of lipid metabolism disorders by a mechanism involving inhibition of miR-21 expression and consequent upregulation of PPARalpha expression.
lncRNA target	35222033	hsa-mir-21	Diabetic Nephropathies	Inhibition of miR-21 expression or Fenofibrate (PPARalpha agonist) administration prevented the decrease of PPARalpha in renal tubular epithelial cells under high glucose (HG) and high fat (Palmitic acid, PA) conditions, alleviating lipid metabolism disorders and reducing mitochondrial dynamics and inflammation. Based on these observations, we conclude that Atorvastatin inhibits tubular epithelial cell injury in T1DM with concomitant induction of lipid metabolism disorders by a mechanism involving inhibition of miR-21 expression and consequent upregulation of PPARalpha expression.
other	35221916	hsa-mir-150	Epilepsy	5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy.
other	35221916	hsa-mir-342	Epilepsy	5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy.
other	35221916	hsa-mir-584	Epilepsy	5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy.
genetics_overexpression_promote	35220908	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	3p facilitated cell apoptosis rate and autophagy substrates LC3BII and Beclin-1, but curbed the colony-formation and DNA replication ability of NSCLC, glucose consumption, lactic acid production, glycolytic rate-limiting enzyme HK-2 and glutamine hydrolase GLS1 and P62, while overexpressed circEHD2 was adverse.
other	35220907	hsa-mir-326	Carcinoma, Hepatocellular	The data illustrated that circ_0008043 and RAB21 were highly expressed, while miR-326 was expressed at less levels in HCC tissues and cells. In summary, silencing of circ_0008043 impeded HCC progression by regulating the miR-326/RAB21 axis.
lncRNA target	35220889	hsa-mir-4262	Nasopharyngeal Carcinoma	Salidroside can significantly inhibit the proliferation and promote the apoptosis of NPC cells via regulating miR-4262/GRP78 signal axis.
genetics_knock down_promote	35220878	hsa-mir-655	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	In conclusion, we confirmed for the first time that lncRNA EBLN3P is dysregulated in T-ALL cell lines, and lncRNA EBLN3P knockdown inhibited the malignant biological behaviors of T-ALL cells by up-regulating miR
genetics_knock down_suppress	35220873	hsa-mir-1256	Stomach Neoplasms	The inhibition effect of circ_0008035 knockdown on the malignant behavior of GC cells could be reversed by miR-1256 inhibitor. Collectively, circ_0008035 regulated the expression of CEACAM6 by sponging miR-1256, thereby promoting the development of GC.
lncRNA target	35220863	hsa-mir-142	Acute Kidney Injury	Our data revealed that p53 inhibition could attenuate cisplatin-induced acute kidney injury by up-regulating miR
genetics_knock down_promote	35220610	hsa-mir-1290	Prostatic Neoplasms	We performed CCK-8, clone forming, Transwell, and sphere formation assays for examining PC cells' malignant phenotypes following miR-1290 knockdown.
other	35220397	hsa-mir-646	Squamous Cell Carcinoma of Head and Neck	Functional experiments further revealed that miR-646 reversed the autophagy and apoptosis effects of circ-PKD2 in OSCC cells treated with cisplatin.
transcription factor target	35220277	hsa-mir-375	Carcinoma, Pancreatic Ductal	In conclusion, amplification of AK4P1 may fuel the onset and development of PDAC by targeting YAP1 through competitively binding to miR-375, and serve as a promising biomarker and therapeutic target for PDAC.
genetics_knock down_promote	35219894	hsa-mir-29a	Fibrosis	Consistently, hepatic miR-29a loss and increased LC3 expression in myofibroblastic HSC were associated with increased serum miR-29a levels in CCl(4)-treated murine liver fibrosis and specimens of hepatitis C virus patients with chronic liver disease.
circulation_biomarker_diagnosis_ns	35219894	hsa-mir-29a	Hepatitis C, Chronic	Hepatic and serum miR-29a levels were quantified by using both liver tissue and serum samples from a cohort of chronic hepatitis C virus patients and a murine CCl(4) induced liver fibrosis model.
other	35219767	hsa-mir-34b	Azoospermia, Nonobstructive	In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA.
other	35219767	hsa-mir-449a	Azoospermia, Nonobstructive	In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA.
other	35219767	hsa-mir-34c	Azoospermia, Nonobstructive	In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA.
genetics_overexpression_promote	35219754	hsa-mir-142	Alzheimer Disease	RESULTS: Overexpressed miR
genetics_knock down_promote	35219686	hsa-mir-182	Glioma	5p overexpression.
genetics_knock down_promote	35219069	hsa-mir-361	Osteosarcoma	3p was demonstrated to promote the proliferation, migration and invasion of osteosarcoma cells; knockdown of miR
genetics_overexpression_promote	35218724	hsa-mir-198	Osteosarcoma	E2F2 was a direct target of miR-198, and miR-198 overexpression regulated OS cell progression in vitro by down-regulating E2F2.
epigenetics	35218115	hsa-mir-141	Leukemia, Prolymphocytic, T-Cell	Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks.
epigenetics	35218115	hsa-mir-200c	Leukemia, Prolymphocytic, T-Cell	Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks.
lncRNA target	35218109	hsa-mir-1270	Uterine Cervical Neoplasms	CONCLUSION: KCNQ1OT1/miR-1270/LOXL2 axis modulated viability and apoptosis of cervical cancer cells.
genetics_knock down_promote	35217880	hsa-mir-376a	Heart Failure	Both miR-376a-3p knockdown and TRAF6 overexpression annulled the protective role of CREB1 overexpression in cardiac function of HF rats.
lncRNA target	35217336	hsa-mir-224	Cardiomyopathies	CONCLUSION: Our study demonstrates that the KCNQ1OT1 suppresses myocardial injury via mediating miR
lncRNA target	35217336	hsa-mir-224	Myocardial Injury	CONCLUSION: Our study demonstrates that the KCNQ1OT1 suppresses myocardial injury via mediating miR
other	35217024	hsa-mir-27b	Fibrosis	Cytochrome P(450) family 1, subfamily B, polypeptide 1 (CYP1B1), involved in metabolism of dietary toxins is negatively regulated by miR-27b and linked with the nuclear factor kappa B (NF-kappaB) pathway and peroxisome proliferator activated receptor gamma (PPAR) in renal fibrosis.
lncRNA target	35216934	hsa-mir-539	Triple Negative Breast Neoplasms	CONCLUSION: LINC00466 promotes the progression of TNBC via regulating miR
genetics_overexpression_promote	35216636	hsa-mir-365	Squamous Cell Carcinoma of Head and Neck	Overexpression of CASC15 and cyclin D1 led to promoted, while overexpression of miR-365 led to inhibited LSCC cell proliferation.
genetics_GWAS	35216394	hsa-mir-193a	Ovarian Neoplasms	When applied to estrogen receptor signaling pathways, the miR-193a targets E2F6 (a target of estrogen receptor), c-KIT (a marker for cancer stemness), and PBX1 (a transcriptional activator for immunosuppressive cytokine, IL-10) in ovarian cancer, such that epigenetic silencing of miR-193a by E2F6 protein is required for the significant change of c-KIT and PBX1 mRNA level for cancer stemness and immunoevasion, respectively, in ovarian cancer carcinogenesis.
circulation_biomarker_diagnosis_down	35216319	hsa-mir-199b	Rectal Neoplasms	Altogether, our findings here demonstrate the functional relevance of miR-199b in this disease and its potential value as a novel circulating marker in LARC.
genetics_overexpression_promote	35216284	hsa-mir-99b	Wilms Tumor	In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups.
genetics_overexpression_promote	35216284	hsa-mir-200a	Wilms Tumor	In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups.
genetics_overexpression_promote	35216284	hsa-mir-182	Wilms Tumor	In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups.
lncRNA target	35216222	hsa-mir-1246	Colonic Neoplasms	To conclude, the present study revealed possible involvement of hsa-miR-1246 in early colorectal cancer development and regulation of tumor suppressors AXIN2 and CFTR.
circulation_biomarker_diagnosis_ns	35215330	hsa-mir-21	Pulmonary Disease, Chronic Obstructive	Carbocysteine Modifies Circulating miR-21, IL-8, sRAGE, and fAGEs Levels in Mild Patients with Chronic Obstructive Pulmonary Disease (COPD) periodically experience acute exacerbation (AECOPD).
other	35215172	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	3p can distinguish cancer and control patients with high sensitivity.
other	35215172	hsa-mir-424	Squamous Cell Carcinoma of Head and Neck	3p can distinguish cancer and control patients with high sensitivity.
other	35215172	hsa-mir-345	Squamous Cell Carcinoma of Head and Neck	3p can distinguish cancer and control patients with high sensitivity.
other	35215154	hsa-mir-548	Squamous Cell Carcinoma of Head and Neck	3p expression increased in the OSCC group compared to the control group.
lncRNA target	35213977	hsa-mir-539	Choroidal Neovascularization	iRGD-PLGA.NPs are promising approaches that reduced the viability of HRMECs, suggesting their therapeutic potential in the treatment of CNV.
lncRNA target	35213720	hsa-mir-205	Thyroid Cancer, Papillary	mimics or GGCT inhibitors as potential therapeutics for PTC may have remarkable applications.
circulation_biomarker_diagnosis_ns	35213638	hsa-mir-146a	Arthritis	In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively.
circulation_biomarker_diagnosis_ns	35213638	hsa-mir-146a	Collagen Diseases	In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively.
circulation_biomarker_diagnosis_ns	35213638	hsa-mir-155	Arthritis	In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively.
circulation_biomarker_diagnosis_ns	35213638	hsa-mir-155	Collagen Diseases	In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively.
other	35213356	hsa-mir-218	Gastrointestinal Stromal Tumors	Our findings indicate that a small number of miRNAs, with hsa-miR218-5p as a focus, may strongly affect the prognosis of GISTs.
lncRNA target	35213273	hsa-mir-143	Thyroid Cancer, Papillary	Next, over-expression of miR-143 suppressed PTC cell growth as analyzed by MTT, clone formation, and Ki-67 immunofluorescence staining assays.
genetics_knock down_suppress	35213267	hsa-mir-7	Glioma	In our experiments, the relative expression level of circRNA_0067934 and miR-7 in glioma tissue was detected by qRT-PCR, and specific gene knockdown was mediated by siRNA and miRNA-inhibitor.
exosome	35212942	hsa-mir-155	Human Herpesvirus 6 encephalitis	Comparative analysis determined that some miRNAs (miR3p, miR-155) were exclusively expressed in the CSF exosomes of AED but not of FS patients, suggesting their potential application as novel diagnostic biomarkers for AED.
exosome	35212942	hsa-mir-381	Human Herpesvirus 6 encephalitis	Comparative analysis determined that some miRNAs (miR3p, miR-155) were exclusively expressed in the CSF exosomes of AED but not of FS patients, suggesting their potential application as novel diagnostic biomarkers for AED.
circulation_biomarker_diagnosis_ns	35212793	hsa-mir-26a	Esophageal Squamous Cell Carcinoma	There were positive and negative strong correlations between miRNAs (miR-26a-5p and miR-205), target genes (LHCGR and CASP3) during different stages of CL, and steroid hormones in the serum.
circulation_biomarker_diagnosis_ns	35212793	hsa-mir-205	Esophageal Squamous Cell Carcinoma	There were positive and negative strong correlations between miRNAs (miR-26a-5p and miR-205), target genes (LHCGR and CASP3) during different stages of CL, and steroid hormones in the serum.
circRNA target	35212614	hsa-mir-30	Prostatic Neoplasms	In conclusion, our data confirmed that circMID1 might play a pro-cancer role in PCa, which promoted PCa progression through regulating the miR
other	35212610	hsa-mir-633	Atherosclerosis	Taken together, hsa_circ_0008896 regulated the expression of CDC20B by sponging hsa-miR-633, and then enhanced proliferation, migration, and invasion of VSMCs to promote the progression of atherosclerosis.
lncRNA target	35212607	hsa-mir-449a	Neuroblastoma	In conclusion, Silencing of PEG10 could inhibit proliferation, migration, and invasion via the miR-449a/RPS2 axis in NB cells.
genetics_overexpression_promote	35212603	hsa-mir-124	Carcinoma, Hepatocellular	Moreover, circHIPK3 overexpression reversed the inhibitory effect of miR-124 or miR-506 on HCC progression.
genetics_overexpression_promote	35212603	hsa-mir-506	Carcinoma, Hepatocellular	Moreover, circHIPK3 overexpression reversed the inhibitory effect of miR-124 or miR-506 on HCC progression.
circRNA target	35212425	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	Together, results demonstrated that hsa_circ_0041268 acted as tumor promoter through novel hsa_circ_0041268/miR5p/ROCK1 axis, which highlighted its potential as NSCLC therapeutic agent.
transcription factor target	35211763	hsa-mir-200c	Myocardial Reperfusion Injury	Together, the results of the present study demonstrated that propofol postconditioning inhibited miR200c3p, upregulated AdipoR2 and activated the STAT3 signaling pathway, thus alleviating diabetic MI/RI and therefore highlighting its potential as a treatment of diabetic MI/RI.
genetics_knock down_promote	35211755	hsa-mir-141	Osteosarcoma	In summary, the present study determined that circLRP6 knockdown inhibited the proliferation, migration and invasion of OS cells by regulating the miR1413p/HDAC4/HMGB1 axis.
lncRNA target	35211508	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	3p/NCAPG axis in NSCLC may shed light on how NCAPG may act as a therapeutic target for NSCLC.
exosome	35211463	hsa-mir-218	Sciatic Neuropathy	Furthermore, in a sciatic nerve injury model, exosomes delivering miR-218 combined with engineered scaffold facilitated the regeneration of injured sciatic nerves.
exosome	35211463	hsa-mir-218	Hypocapnia	In the present study, we analyzed the functional differences of secreted exosomes in response to hypocapnia stimulation, and explored the application in combination with miR-218 to facilitate sciatic nerve regeneration. Our results indicated that the delivery system of engineered exosomes derived from ASCs remarkably loads upregulated miR-218 and promotes cellular activity in the recipient cells (PC12 cells), and hypocapnia stimuli-responsive exosomes exhibit strengthening properties.
other	35211156	hsa-mir-378a	Cardiomegaly	Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy.
other	35211156	hsa-mir-27b	Cardiomegaly	Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy.
other	35211156	hsa-mir-20a	Cardiomegaly	Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy.
other	35211156	hsa-mir-342	Cardiomegaly	Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy.
target gene	35211152	hsa-mir-103a	Prostatic Neoplasms	Upregulation of miR-103a-3p and interference with TRIM66 can inhibit DTX resistance and glycolysis of PCa cells.
other	35211114	hsa-mir-126	Otofaciocervical Syndrome	Hsa-miR5p is potentially a very promising diagnostic biomarker for CE.
circulation_biomarker_diagnosis_ns	35210895	hsa-mir-126	Leukemia, Myeloid, Acute	5p was measured in the plasma of 43 adult AML patients and 35 age- and sex-matched controls by quantitative reverse transcriptase PCR.
circulation_biomarker_diagnosis_ns	35210895	hsa-mir-423	Leukemia, Myeloid, Acute	5p was measured in the plasma of 43 adult AML patients and 35 age- and sex-matched controls by quantitative reverse transcriptase PCR.
other	35210837	hsa-mir-3199	Colonic Neoplasms	This research intended to evaluate the prognostic values of LINC01006 and miR-3199 for colon cancer and their effects on cell physiology. High LINC01006 level (HR = 4.048, 95%: 1.502-10.911, P = 0.006) or low miR-3199 level (HR = 3.421, 95% CI: 1.254-9.330, P = 0.016) was outstanding for predicting poor prognosis in patients with colon cancer.
other	35210471	hsa-mir-10b	Huntington Disease	We found that hsa-mir-10b-5p was edited to have an additional cytosine at 5'-end in HD-PC, and the edited hsa-mir-10b repressed GTPBP10 that was often downregulated in HD.
exosome	35210436	hsa-mir-19b	Squamous Cell Carcinoma of Head and Neck	The corresponding data demonstrated that the M1 exosomal lncRNA HOTTIP suppresses HNSCC progression by upregulating the TLR5/NF-kappaB signaling pathway through competitively sponging miR-19a-3p and miR-19b-3p.
transcription factor target	35210412	hsa-mir-509	Ovarian Neoplasms	In conclusion, our results suggested that SF3B4, negatively regulated by miR3p, promoted OC progression through effective splicing of RAD52.
transcription factor target	35210391	hsa-mir-150	Neuralgia	In conclusion, we demonstrated an essential function of METTL3-regulated N6-methyladenosine during NP progression via modulating primiR-150 maturation. Therefore, the METTL3/miR-150/BDNF pathway may be a promising therapeutic target for NP patients.
other	35209928	hsa-mir-326	Pneumonia, Mycoplasma	In this study, placental tissues taken from healthy donors and PE patients were used to evaluate the miR-326 expression; CCK8 and colony formation assays were used to confirm the effect of miR-326 on cell proliferation; transwell assay was used to demonstrate the effect of miR-326 on cell invasion capability; western blot was used to investigate the underlying mechanism; and luciferase assay was used to detect the effect of miR-326 on YAP/TAZ-mediated transcription activity. It was revealed the miR-326 expression was higher in placentas from PE patients than from healthy donors.
other	35208504	hsa-mir-192	Celiac Disease	5p, miR-449a and miR-638) in adult patients with CD.
other	35208504	hsa-mir-194	Celiac Disease	Among the miRNAs, the closest to a statistically significant value was miR5p when the newly diagnosed group versus control (p = 0.0510) and GFD group versus control (p = 0.0671) were compared.
other	35208504	hsa-mir-638	Celiac Disease	5p, miR-449a and miR-638) in adult patients with CD.
other	35208504	hsa-mir-449a	Celiac Disease	5p, miR-449a and miR-638) in adult patients with CD.
circulation_biomarker_diagnosis_up	35207812	hsa-mir-155	COVID-19	We found that mild COVID-19 patients had 2.5-fold less circulating miR-155 than healthy people, and patients with a severe COVID-19 disease had 5-fold less circulating miR-155 than healthy people.
other	35207076	hsa-mir-6727	Wound Healing	Homo Sapiens (Hsa)-microRNA (miR)-6727-5p Contributes to the Impact of High-Density Lipoproteins on Fibroblast Wound Healing In Vitro.
transcription factor target	35205813	hsa-mir-1244	Lymphoma, Large B-Cell, Diffuse	In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability.
transcription factor target	35205813	hsa-mir-1231	Lymphoma, Large B-Cell, Diffuse	In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability.
transcription factor target	35205813	hsa-mir-193b	Lymphoma, Large B-Cell, Diffuse	In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability.
other	35205713	hsa-mir-143	Urinary Bladder Neoplasms	Long Noncoding RNA LINC02470 Sponges MicroRNA-143-3p and Enhances SMAD3-Mediated Epithelial-to-Mesenchymal Transition to Promote the Aggressive Properties of Bladder Cancer.
other	35205710	hsa-mir-101	Lung Neoplasms	3p is associated with tumorigenesis.
other	35205648	hsa-mir-195	Colorectal Neoplasms	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-375	Adrenocortical Carcinoma	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-210	Colorectal Neoplasms	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-483	Colorectal Neoplasms	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-195	Adrenocortical Carcinoma	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-503	Colorectal Neoplasms	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-503	Adrenocortical Carcinoma	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-210	Adrenocortical Carcinoma	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-483	Adrenocortical Carcinoma	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205648	hsa-mir-375	Colorectal Neoplasms	We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%.
other	35205607	hsa-mir-126	Carcinoma, Renal Cell	The hsa-miR3p/hsa-miR-200b-3p panel identified the most common RCC subtype (clear cell, ccRCC) with 74.78% sensitivity.
other	35205607	hsa-mir-200b	Carcinoma, Renal Cell	The hsa-miR3p/hsa-miR-200b-3p panel identified the most common RCC subtype (clear cell, ccRCC) with 74.78% sensitivity.
lncRNA target	35205327	hsa-mir-874	Carcinoma, Hepatocellular	The study goal was to examine VEGFA (vascular endothelial growth factor A) expression in hepatocellular carcinoma (HCC) cell lines upon transfection miR-612, miR-637, or miR-874. Methods: MiR-612 mimics, miR-637 mimics, or miR-874 inhibitors were transfected using Lipofectamine RNAiMax in both HCC cell lines, HepG2 and HuH-7.
lncRNA target	35205327	hsa-mir-637	Carcinoma, Hepatocellular	The study goal was to examine VEGFA (vascular endothelial growth factor A) expression in hepatocellular carcinoma (HCC) cell lines upon transfection miR-612, miR-637, or miR-874. Methods: MiR-612 mimics, miR-637 mimics, or miR-874 inhibitors were transfected using Lipofectamine RNAiMax in both HCC cell lines, HepG2 and HuH-7.
other	35205276	hsa-mir-101	Frailty	5p were found to be downregulated in the frail vs.
other	35205276	hsa-mir-142	Frailty	5p were found to be downregulated in the frail vs.
other	35205216	hsa-mir-142	Hashimoto Disease	3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT.
other	35205216	hsa-mir-22	Hashimoto Disease	3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT.
other	35204817	hsa-mir-199a	Leg Ulcer	Furthermore, in silico analyses indicated interactions of miR-199a-5p with HIF1A, Ets-1, and TGFB2 genes, which are associated with vasculopathy and reduced NO.
circulation_biomarker_diagnosis_ns	35204817	hsa-mir-126	Leg Ulcer	The circulating miR-126 may play a protective role in SLU.
other	35204816	hsa-mir-193b	Osteoarthritis	Moreover, when both conditions were analyzed together, miR3p resulted the most stable RGs, allowing for a sharper comparison of EVs content, further validated on the OA-related miRNA-193b-5p.
other	35204816	hsa-mir-24	Osteoarthritis	Moreover, when both conditions were analyzed together, miR3p resulted the most stable RGs, allowing for a sharper comparison of EVs content, further validated on the OA-related miRNA-193b-5p.
other	35204460	hsa-mir-374c	Tuberculosis	Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels.
other	35204460	hsa-mir-199a	Tuberculosis	Among them, miR-199a-3p and miR3p can differentiate between ATB and LTBI.
other	35204460	hsa-mir-199b	Tuberculosis	Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels.
other	35204460	hsa-mir-16	Tuberculosis	Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels.
other	35204460	hsa-mir-6886	Tuberculosis	Among them, miR-199a-3p and miR3p can differentiate between ATB and LTBI.
circulation_biomarker_diagnosis_ns	35203931	hsa-mir-206	Schizophrenia	were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment.
circulation_biomarker_diagnosis_ns	35203931	hsa-mir-132	Schizophrenia	were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment.
circulation_biomarker_diagnosis_ns	35203931	hsa-mir-124	Schizophrenia	were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment.
other	35203692	hsa-mir-29a	Diabetes, Gestational	The change over time only differed for miR-29a-3p when comparing women with GDM with those remaining NGT (p = 0.044).
other	35203467	hsa-mir-20a	Growth Disorders	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-20a	Pre-Eclampsia	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-20a	Hypertension, Pregnancy-Induced	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-20a	Cardiovascular Diseases	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-146a	Pre-Eclampsia	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-146a	Hypertension, Pregnancy-Induced	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-146a	Cardiovascular Diseases	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-146a	Growth Disorders	3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation.
other	35203467	hsa-mir-181a	Cardiovascular Diseases	Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR).
other	35203467	hsa-mir-181a	Hypertension, Pregnancy-Induced	Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR).
other	35203467	hsa-mir-181a	Pre-Eclampsia	Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR).
other	35203467	hsa-mir-181a	Growth Disorders	Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR).
circulation_biomarker_prognosis_ns	35203396	hsa-mir-8074	Multiple Myeloma	Circulating Serum MiRNA-8074 as a Novel Prognostic Biomarker for Multiple MiRNA-8074 is a molecule with the potential to regulate the expression of key genes related to the pathogenesis of multiple myeloma (MM), i.e., TP53, MYC, MAPK1, and KIAA.
other	35203389	hsa-mir-150	Myasthenia Gravis	Levels of miR-30e-5p and miR5p significantly differed between MG patients and healthy controls; however, no difference was seen compared with patients affected by other neuroimmune diseases.
genetics_overexpression_suppress	35203290	hsa-mir-429	Carcinoma, Transitional Cell	METHODS: Quantitative RT-PCR, immunoblotting assay and tube formation examined the effect of hsa-miR-429 mimic or/and inhibitor on VEGFA expression and angiogenesis in CEBPD-overexpressing UC-derived cells.
other	35203245	hsa-mir-21	Nephritis, Hereditary	These results support the addition of anti-miR-21 to the current standard of care (ACEi) in ongoing clinical trials in patients with Alport syndrome.
circRNA target	35203042	hsa-mir-1	Arthritis	Additionally, consecutive rescue experiments indicated that the inhibitory impacts of TPL on RA-FLSs were dependent on the circ0003353/miR
circRNA target	35203042	hsa-mir-1	Arthritis, Rheumatoid	Additionally, consecutive rescue experiments indicated that the inhibitory impacts of TPL on RA-FLSs were dependent on the circ0003353/miR
lncRNA target	35202986	hsa-mir-149	Osteoarthritis	CONCLUSION: These finding demonstrated that SOX4-activated MCM3AP-AS1 aggravated OA progression by modulating autophagy and ECM degradation via targeting miR5p/Notch1 axis.
other	35202801	hsa-mir-1	Bronchiolitis Obliterans Syndrome	Among the core miRNAs, miR3p and miR-335 were differentially expressed in IRI rats.
other	35202801	hsa-mir-335	Bronchiolitis Obliterans Syndrome	Among the core miRNAs, miR3p and miR-335 were differentially expressed in IRI rats.
lncRNA target	35202706	hsa-mir-20a	Diabetic Retinopathy	In conclusion, MALAT1 inhibits HIF-1alpha expression and MRMECs angiogenesis in DR through spongy miR-320a.
genetics_GWAS	35202641	hsa-mir-454	Carcinoma, Non-Small-Cell Lung	Interestingly, SNP rs1127317 locating in the ADAR 3'-untranslated region regulates gene expression in an allele-specific manner via modulating binding of miR5p in cells.
circRNA target	35202487	hsa-mir-548b	Glioblastoma	In conclusion, the present study demonstrated that a circBFAR/miR-548b/FoxM1 axis regulates the development of GBM and highlights potentially novel therapeutic targets for the treatment of GBM.
lncRNA target	35202090	hsa-mir-410	Immune System Diseases	This research provides novel insights into immune dysfunction contributing to infection outcomes and suggests the use of the antagomiRs/inhibitors of miR-294 and miR-410 as new therapeutic strategies to modulate inflammation and to decrease parasitism.
lncRNA target	35202090	hsa-mir-294	Immune System Diseases	This research provides novel insights into immune dysfunction contributing to infection outcomes and suggests the use of the antagomiRs/inhibitors of miR-294 and miR-410 as new therapeutic strategies to modulate inflammation and to decrease parasitism.
other	35202085	hsa-mir-183	Prostatic Neoplasms	Overall, cell adhesion was uncovered as a major pathway controlled by miR-183 in prostate cancer, and ITGB1 was identified as a relevant mediator of this effect.
other	35202022	hsa-mir-370	Pre-Eclampsia	One of the differentially expressed miRNAs, hsa-miR3p, which was upregulated in the preeclampsia group, was shown to bind to the 3' untranslated region of C-X-C motif chemokine 12, a chemokine that plays important role during preeclampsia process.
circulation_biomarker_diagnosis_up	35202004	hsa-mir-451a	Anaphylaxis	Blood samples were taken upon emergency room arrival and 1 month later.ResultsNext-generation sequencing of 18 samples (6 patients with anaphylaxis in both acute and nonacute condition, for 12 total samples, and 6 healthy controls) identified hsa-miR-451a to be elevated during anaphylaxis, which was verified by quantitative real-time PCR in the remaining cohort. We identified tryptase, 9alpha,11beta-PGF2, apolipoprotein A1, and hsa-miR-451a as serological biomarkers of anaphylaxis.
other	35202001	hsa-mir-223	Atherosclerosis	3p.
genetics_overexpression_promote	35201653	hsa-mir-186	Squamous Cell Carcinoma of Head and Neck	The overexpression of miR
other	35201491	hsa-mir-1	Carcinoma, Hepatocellular	3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development.
other	35201491	hsa-mir-29	Carcinoma, Hepatocellular	3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development.
other	35201491	hsa-mir-4435-2	Carcinoma, Hepatocellular	3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development.
exosome	35201481	hsa-mir-20a	Ovarian Neoplasms	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer.
target gene	35201478	hsa-mir-26a	Pancreatic Neoplasms	microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7.
target gene	35201476	hsa-mir-376a	Osteosarcoma	Silencing long intergenic non-protein coding RNA 00987 inhibits proliferation, migration, and invasion of osteosarcoma cells by sponging miR-376a-5p to regulate FNBP1 expression.
transcription factor target	35201360	hsa-mir-199a	Lung Diseases	After ozone exposure, miR-199a-3p, but not precursor miR-199a-3p, was increased in lung macrophages, indicating that it is derived from MV-mediated delivery. Furthermore, lung macrophage mRNA expression of IL-1beta was upregulated after administration of MVs containing miR-199a-3p mimic but downregulated by miR-199a-3p inhibitor.
other	35200555	hsa-mir-127	Breast Neoplasms	Upregulation of miR-127 correlated with pCR in triple-negative breast cancer (TNBC).
genetics_overexpression_promote	35200157	hsa-mir-942	Urinary Bladder Neoplasms	Rescue experiments showed that suppression of miR-942 or BARX2 overexpression could significantly abrogate the promoting effects of circSHPRH silencing on BCa cell proliferation and invasion.
genetics_knock down_promote	35200111	hsa-mir-1298	Stomach Neoplasms	5p interference or ZBED3 overexpression showed the opposite trend.
exosome	35200105	hsa-mir-15a	Wilms Tumor	Moreover, tumor formation tests further assessed the role of exosomal miR-15a-5p in WT.
exosome	35200104	hsa-mir-23a	Cholangiocarcinoma	Exosomal microRNA-23a-3p contributes to the progression of cholangiocarcinoma by interaction with Dynamin3.
lncRNA target	35200103	hsa-mir-495	Fibrosis	In summary, NORAD silencing inhibited hepatic fibrosis by suppressing HSC activation via the miR
other	35200096	hsa-mir-1269b	Hemangioma	The expression of BRCAT54 and miR-1269b in hemangioma samples, as well as hemangioma-derived endothelial cells (HDECs) and human umbilical vein endothelial cells (HUVECs) were detected by RT-qPCR.
genetics_overexpression_suppress	35199943	hsa-mir-421	Sepsis	Our data demonstrated that in the LPS-induced sepsis model of myocardial cells, SNHG16 overexpression downregulated the expression level of miR-421, which sustained the expression of SOCS5 to alleviate the adverse effects of LPS, such as apoptosis, pro-inflammatory cytokines, and oxidative stress. Targeting miR-421 or modulating lncRNA SNHG16 level may be leveraged as a beneficial strategy against sepsis-induced cellular damage in cardiomyocytes.
genetics_overexpression_suppress	35199943	hsa-mir-421	Cardiomyopathies	Our data demonstrated that in the LPS-induced sepsis model of myocardial cells, SNHG16 overexpression downregulated the expression level of miR-421, which sustained the expression of SOCS5 to alleviate the adverse effects of LPS, such as apoptosis, pro-inflammatory cytokines, and oxidative stress. Targeting miR-421 or modulating lncRNA SNHG16 level may be leveraged as a beneficial strategy against sepsis-induced cellular damage in cardiomyocytes.
genetics_knock down_promote	35199939	hsa-mir-627	Thyroid Cancer, Papillary	Overexpression of miR-627 in PTC inhibited the proliferation, migration, and invasion by down-regulating the expression of TRIM44.
lncRNA target	35199935	hsa-mir-195	Pancreatic Carcinoma	In summary, CERS6-AS1 facilitates PC cell proliferation while inhibiting PC cell apoptosis by upregulating WIPI2 via miR
other	35199873	hsa-mir-190a	Carcinoma, Hepatocellular	CONCLUSION: Our results suggested that circ_0008194 may act as a sponge to adsorb miR-190a, thereby promoting the expression of AHNAK and promoting the metastasis of liver cancer tumors.
exosome	35199612	hsa-mir-618	Liver Cirrhosis	These findings indicated that treatment of exosomal miR-618 derived from MSCs might serve as a new strategy for HF.
circRNA target	35199365	hsa-mir-6165	Carcinoma, Hepatocellular	Mechanistically, we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC.
circulation_biomarker_diagnosis_ns	35199358	hsa-mir-34a	Cardiotoxicity	This association between plasma and heart may suggest miR-34a-5p as a potential early circulating marker of early-onset DOX cardiotoxicity. In addition, higher expression of miR-34a-5p (FDR &lt; 0.1) in plasma and heart compared with SAL-treated controls 24 weeks after 24 mg/kg total cumulative DOX dose, when cardiac function was altered in our recently established delayed-onset cardiotoxicity model, indicated its potential as an early biomarker of delayed-onset cardiotoxicity.
target gene	35198876	hsa-mir-1273g	Colorectal Neoplasms	p73-regulated FER1L4 lncRNA sponges the oncogenic potential of miR-1273g-3p and aids in the suppression of colorectal cancer metastasis.
epigenetics	35198364	hsa-mir-451a	Osteosarcoma	MiR-451a promotes cell growth, migration and EMT in osteosarcoma by regulating YTHDC1-mediated m6A methylation to activate the AKT/mTOR signaling pathway.
genetics_overexpression_promote	35198058	hsa-mir-15a	Liver Injury	Conclusions: Galpha(12) overexpression by ER stress facilitates hepatocyte ferroptosis through ROCK1-mediated dysregulation of ALOX12, and miR-15a, supporting the concept that inhibition of Galpha(12) overexpression and/or ROCK1 axis may constitute a promising strategy for acute liver injury.
genetics_overexpression_promote	35198024	hsa-mir-526b	Glioma	Overexpression of miR-526b-3p within ADR-resistant glioma cells obtained similar results, which suggested miR-526b-3p suppressed glioma cell resistance to ADR.
other	35197661	hsa-mir-21	Prostatic Neoplasms, Castration-Resistant	CONCLUSION: There is a significant difference in the expression values of miRNA-21 between BPH with CRPC and Prostate cancer and CRPC, therefore, miRNA-21 cut-off point is potential to differentiate the diagnosis.
other	35197055	hsa-mir-199a	Carcinoma, Hepatocellular	RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed.
other	35197055	hsa-mir-126	Carcinoma, Hepatocellular	RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed.
other	35197055	hsa-mir-15a	Carcinoma, Hepatocellular	RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed.
other	35197055	hsa-mir-148a	Carcinoma, Hepatocellular	RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed.
other	35196982	hsa-mir-424	Neurotoxicity Syndromes	miR-424 has the potential to regulate the neurotoxicity caused by isoflurane anesthesia, and it has a complementary sequence with the 3'UTR region of TLR4. Thus, our study aims to explore whether sevoflurane directly causes neurotoxicity, the effects of miR-424 on sevoflurane induced apoptosis and inflammation, and the underlying mechanism.
genetics_knock down_promote	35196944	hsa-mir-532	Ovarian Neoplasms	3p, and circ_0025033 knockdown blocked the malignant activities of PTX-resistant OC cells by enriching miR
lncRNA target	35196925	hsa-mir-189	Osteoarthritis	CONCLUSION: Circ_0110251 protected chondrocytes from IL-1beta-induced apoptosis and ECM degradation in OA via sponging miR3p and elevating SPRY1.
target gene	35196780	hsa-mir-24	Leukemia, Myeloid, Acute	lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells
genetics_overexpression_promote	35196590	hsa-mir-214	Intervertebral Disc Degeneration	Collectively, these data suggest that ADIRF-AS1 overexpression could mitigate IDD by binding to miR
circulation_biomarker_diagnosis_up	35196550	hsa-mir-155	Carcinoma, Hepatocellular	METHODS: Exosomal miR-155 quantity was analyzed by sampling serum exosomes of patients with hepatocellular carcinoma and normal subjects.
lncRNA target	35196388	hsa-mir-206	chikungunya	METHODS: We evaluated the vaccine potential of a recently described LAV, skeletal muscle-restricted virus (SKE), that exhibits diminished replication in skeletal muscle due to insertion of target sequences for skeletal muscle-specific miR-206.
genetics_overexpression_promote	35196205	hsa-mir-147a	Nasopharyngeal Carcinoma	The promotion effect of circSETD3 overexpression on NPC proliferation and DDP resistance and inhibition effect on apoptosis was reversed by elevated miR-147a. In conclusion, the results of this study confirm that circSETD3 promotes NPC proliferation and DDP resistance by regulating miR-147a, and circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC in the future.
other	35196197	hsa-mir-376a	Carcinoma, Non-Small-Cell Lung	These results suggest that circ-UBE2D2 promotes the proliferation, migration and invasion but restrains apoptosis of lung cancer cells by regulating miR-376a-3p/EIF4G2 axis.
genetics_knock down_promote	35196196	hsa-mir-4461	Gallbladder Neoplasms	Special EGFR siRNA or AKT overexpression virus abolishes the discrepancy of self-renewal, tumorigenesis, growth, and metastasis between miR-4461 overexpression GBC cells and their control cells.
circRNA target	35196193	hsa-mir-940	Carcinoma, Non-Small-Cell Lung	In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment.
genetics_overexpression_promote	35196185	hsa-mir-646	Adenocarcinoma of Lung	MiR-3646 overexpression stimulated the proliferation and adhesion of LUAD cells but inhibite d apoptosis, whereas a miR-3646 inhibitor produced the opposite results.
lncRNA target	35195809	hsa-mir-146a	Plaque, Atherosclerotic	However, the effect of miR-146a on the stability of atherosclerotic plaque remains to be elucidated. CONCLUSIONS: We display for the first time that miR-146a inhibits the formation of foam cells, RAW264.7 macrophage apoptosis and pro-inflammatory reaction through negative regulation of IRAK1 and TRAF6 expression, thereby enhancing the stability of atherosclerotic plaques.
other	35195734	hsa-mir-153	Hyperphosphatemia	3p decreased calcium deposition in both uremia rats treated with HP-EMPs or not.
other	35194770	hsa-mir-25	Inflammation	CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states.
other	35194770	hsa-mir-92b	Diabetes Mellitus	This study reported here specifically assessed the association between miR-25/miR-92b family and beta-cell failure in diabetes. CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states.
other	35194770	hsa-mir-25	Diabetes Mellitus	This study reported here specifically assessed the association between miR-25/miR-92b family and beta-cell failure in diabetes. CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states.
other	35194770	hsa-mir-92b	Inflammation	CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states.
other	35194759	hsa-mir-192	Neonatal hemochromatosis	Placental miR5p expression was lower among NHB people and was positively associated with neonatal adiposity, suggesting it may be sensitive to structural racism with potential impacts on fetal growth.
other	35194735	hsa-mir-27	Myocardial Infarction, Acute	3p was downregulated after AMI.
transcription factor target	35194732	hsa-mir-512	Melanoma	3p by suppressing growth of melanoma both in vitro and in vivo targeting the p27 Kip1 axis.
genetics_overexpression_promote	35194440	hsa-mir-142	Glioblastoma	The miR-142 was overexpressed in U-87 glioblastoma cells via lentiviral transduction, and the way it influences proliferation and migration of cells was investigated through MTT assay and wound healing assay. The miR-142 significantly suppressed cell proliferation and migration and induced apoptosis and cell-cycle arrest in U-87 glioblastoma cells.
target gene	35194440	hsa-mir-424	Glioblastoma	Overall, miR-424 acts as tumor suppressor miRNA in glioblastoma cells.
circulation_biomarker_diagnosis_up	35194091	hsa-mir-4645	Cholangitis, Sclerosing, Primary	One of the newly identified miRNAs, miR3p, was significantly up-regulated fourfold in PSC-derived EVs compared to circulating EVs isolated from healthy controls.
other	35193668	hsa-mir-147a	Diabetic Nephropathies	CONCLUSION: In total, our research pointed out that lncRNA HOTAIR could mediate miR-147a/WNT2B axis to promote DN progression.
lncRNA target	35193602	hsa-mir-146a	Esophageal Neoplasms	Moreover, our findings revealed that HDAC4 conferred radioresistance of EC by downregulating microRNA-146a (miR-146a). Silencing of HDAC4 radiosensitized EC cells both in vitro and in vivo via the miR-146a/IRAK1 axis.
lncRNA target	35193567	hsa-mir-561	Pancreatic Carcinoma	5p/LDHA axis, suggesting LINC01128 may be a new prognostic marker and therapeutic target in PC.
exosome	35193488	hsa-mir-524	Liver Neoplasms	CONCLUSIONS: CAFs-derived exosomal TUG1 promoted migration, invasion, and glycolysis in HCC cells via the miR
genetics_overexpression_promote	35193469	hsa-mir-545	Retinoblastoma	3p treatment phenocopied the effect of AFAP1-AS1 overexpression and promoted RB cell growth in vivo.
epigenetics	35193115	hsa-mir-34a	Colonic Neoplasms	BACKGROUND: LncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported to promote resistance to chemotherapy in colon cancer by inhibiting the expression of miR-34a. RESULTS: Carrier of allele 10 and methylated promoter in KCNQ1OT1 was associated with decreased KCNQ1OT1/ATG4B expression, increased miR-34a expression and enhanced apoptosis in colon cancer tissue samples.
transcription factor target	35192930	hsa-mir-1298	Stomach Neoplasms	5p, through which miR
genetics_overexpression_promote	35192807	hsa-mir-205	von Willebrand Diseases	In summary, our findings provide experimental evidence that overexpression of vWF in breast cancer cells down-regulates the expression of miR5p and up-regulates the expression of VEGF-A through the PI3K/Akt signaling pathway, thereby promoting tumor angiogenesis and metastasis.
genetics_overexpression_promote	35192807	hsa-mir-205	Breast Neoplasms	In summary, our findings provide experimental evidence that overexpression of vWF in breast cancer cells down-regulates the expression of miR5p and up-regulates the expression of VEGF-A through the PI3K/Akt signaling pathway, thereby promoting tumor angiogenesis and metastasis.
other	35192776	hsa-let-7	Fanconi Anemia	Our data show that the Fanconi anemia pathway and the H19/let-7/LIN28B axis may be involved in gamma- to beta-globin gene switching.
transcription factor target	35192632	hsa-mir-19b	non-alcoholic steatohepatitis	Therefore, ipragliflozin can improve NASH development likely through the antioxidative stress pathway and by regulating miR-19b-3p.
transcription factor target	35192356	hsa-mir-371b	Colonic Neoplasms	Altogether, these results demonstrated that dietary CE induces CRC cellular senescence via modulating the miR-371b-5p/TFAP4 axis and presents opportunities for potential therapeutic strategies against CRC.
lncRNA target	35191809	hsa-mir-886	Osteosarcoma	Overall, OXCT1-AS1 suppresses miR-886 maturation to promote OS cell proliferation.
circRNA target	35191807	hsa-mir-136	Osteoarthritis	5p/NAMPT axis is momentous in OA progression and is supposed to be a promising therapeutic target for some time.
transcription factor target	35191804	hsa-mir-21	Glioblastoma	In short, Rop exerted an anti-tumor impact on GBM via mediating the miR
genetics_overexpression_promote	35191803	hsa-mir-130b	Triple Negative Breast Neoplasms	In TNBC cells, downregulation of BRCAT54 was observed after the overexpression of miR-130b.
genetics_overexpression_promote	35191745	hsa-mir-148a	Carcinoma, Squamous Cell, Cutaneous	Moreover, miR-148a-3p overexpression inhibited the malignant phenotypes of CSCC cells, with EGFR elevation abrogating the effects.
genetics_knock down_promote	35191420	hsa-mir-217	Carcinoma, Non-Small-Cell Lung	Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells, while the effects were abrogated by elevating APPBP2.
lncRNA target	35191145	hsa-mir-150	Pancreatic Diseases	3p and suppressed expression of PDX1.
transcription factor target	35191055	hsa-mir-451	Prostatic Hyperplasia	We found that TvMIF can enhance RWPE-1 cell proliferation and activate inflammatory factors by suppressing miR-451, thus taking part in the development and proliferation of diseases such as prostatic hyperplasia and prostatitis.
transcription factor target	35191055	hsa-mir-451	Prostatitis	We found that TvMIF can enhance RWPE-1 cell proliferation and activate inflammatory factors by suppressing miR-451, thus taking part in the development and proliferation of diseases such as prostatic hyperplasia and prostatitis.
transcription factor target	35190902	hsa-mir-22	autosomal recessive congenital bilateral absence of vas deferens	These results indicate that miR-22 is an important accelerator of the osteogenic differentiation of VICs, and a potential therapeutic target in CAVD.
other	35190902	hsa-mir-22	Heart Valve Diseases	miR-22 was highly expressed in calcified valve tissues (P < 0.01), and the expression was positively correlated with the expression of OPN (r(s) = 0.820, P < 0.01) and Runx2 (r(s) = 0.563, P < 0.01) in VICs isolated from mild or moderately calcified valves.
lncRNA target	35190765	hsa-mir-296	Femur Head Necrosis	CONCLUSION: lncRNA FGD5-AS1 promotes cell proliferation and inhibits apoptosis in steroid-induced ONFH through acting as a sponge for miR5p and upregulation of STAT3.
other	35190587	hsa-mir-18b	Colorectal Neoplasms	3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration.
other	35190587	hsa-mir-145	Colorectal Neoplasms	3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration.
other	35190587	hsa-mir-718	Colorectal Neoplasms	3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration.
other	35190587	hsa-mir-376b	Colorectal Neoplasms	3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration.
other	35190587	hsa-mir-676	Colorectal Neoplasms	3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration.
other	35190532	hsa-mir-1184	Adenocarcinoma of Lung	Collectively, the circNEIL3/miR-1184/PIF1 axis that mediate pyroptosis induction may be a novel, promising therapeutic strategy for the clinical treatment of lung cancer.
lncRNA target	35189958	hsa-mir-203a	Carcinoma, Pancreatic Ductal	Mechanistically, circCUL2 functioned as a ceRNA and modulated the miR-203a-3p/MyD88/NF-kappaB/IL6 axis, thereby further activating the STAT3 signaling pathway in pancreatic cancer cells to induce PDAC progression. CONCLUSIONS: We showed that the circCUL2/miR-203a-5p/MyD88/NF-kappaB/IL6 axis contributes to the induction of iCAFs and established a distinct fibroblast niche for PDAC progression, which could help the development of strategies that selectively target tumor-promoting CAFs in PDAC.
exosome	35189518	hsa-let-7i	Silicotuberculosis	The study demonstrates that hucMSCs-Exos act as a mediator that transfers let-7i-5p to inhibit the activation of fibroblasts, which alleviates PF through the TGFBR1/Smad3 signaling pathway.
other	35189426	hsa-mir-1	Colonic Neoplasms	3p couldn&#x27;t identify a subgroup of patients with right-sided RAS-wt mCRC who might benefit from anti-EGFR and suggest that Beva is the TT of choice in first-line treatment of these patients.
lncRNA target	35189053	hsa-mir-526b	Melanoma	OBJECTIVE: To investigate the mechanism of LINC00518 affecting the proliferation, invasion, and migration of cutaneous malignant melanoma (CMM) cells via miR-526b-3p/EIF5A2 axis. Transfection of si-LINC00518, miR-526b-5p mimic or si-EIF5A2 weakened the proliferative, migratory, and invasive abilities of melanoma cells, while transfection of miR-526b-5p inhibitor or pcDNA-LINC00518 enhanced the progression of melanoma cells.
other	35189048	hsa-mir-24	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-29c	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-29b	Scleroderma, Systemic	However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples.
other	35189048	hsa-mir-29b	Diabetic Nephropathies	However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples.
other	35189048	hsa-mir-21	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-125b	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-125b	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-27b	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-27b	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-21	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-29a	Scleroderma, Systemic	However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples.
other	35189048	hsa-mir-181b	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-24	Scleroderma, Systemic	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-181b	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-29c	Diabetic Nephropathies	Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera.
other	35189048	hsa-mir-29a	Diabetic Nephropathies	However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples.
circulation_biomarker_diagnosis_up	35188889	hsa-mir-92a	Liver Cirrhosis	CONCLUSION: Serum exosomal miR-92a-3p and miR-146a-5p are superior to APRI, FIB-4, and LSM for diagnosing significant fibrosis in CHB patients and offer a promising non-invasive alternative to liver biopsy.
circulation_biomarker_diagnosis_up	35188889	hsa-mir-146a	Liver Cirrhosis	CONCLUSION: Serum exosomal miR-92a-3p and miR-146a-5p are superior to APRI, FIB-4, and LSM for diagnosing significant fibrosis in CHB patients and offer a promising non-invasive alternative to liver biopsy.
lncRNA target	35188875	hsa-mir-512	Osteoarthritis	AFAP1-AS1 could be a potential target to treat osteoarthritis by inhibiting miR
other	35188872	hsa-mir-146b	Ovarian Failure, Premature 	Therefore, BBOX1-AS1 may increase the apoptosis of granulosa cells in POF by sponging miR-146b.
other	35188689	hsa-mir-137	Alzheimer Disease	Gold nanourchin enhances detection of Alzheimer&#x27;s disease biomarker &quot;miRNA-137&quot; Diagnosis of Alzheimer&#x27;s disease (AD) is a complex task, and at present, neuroimaging such as magnetic resonance imaging and positron emission tomography is commonly used for the diagnosis of AD. This research work developed a new biosensing method with gold nanomaterial to identify AD biomarker of miRNA-137.
circulation_biomarker_diagnosis_ns	35188624	hsa-mir-98	Liver Cirrhosis	Serum miR
circulation_biomarker_diagnosis_down	35188450	hsa-mir-211	Osteoporosis, Postmenopausal	5p was down-regulated in the PMOP patients' plasma (in contrast with the healthy controls), and it was positively correlated with Vit-D and BMD levels.
genetics_overexpression_promote	35188403	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	Overexpression of MAP3K9 attenuated the inhibitory effect of miR-125b-5p on viability and glycolysis, and the pro-apoptosis effect of miR-125b-5p in LSCC cells.
genetics_overexpression_promote	35188072	hsa-mir-2355	Carcinoma, Non-Small-Cell Lung	Mechanically, we showed that silencing of CircSOD2 and overexpression of miR
lncRNA target	35187800	hsa-mir-128	Pre-Eclampsia	In conclusion, BNIP3P1 inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia by targeting the miR3p/BNIP3/mTOR signaling pathway.
genetics_knock down_suppress	35187761	hsa-mir-503	Carcinoma, Hepatocellular	MiR5p inhibition reversed the effects of circ_0011232 knockdown on HCC cell development.
circRNA target	35187741	hsa-mir-558	Intervertebral Disc Degeneration	CONCLUSIONS: hsa_circ_0083756 promoted IVDD via targeting the miR-558/TREM1 axis, and hsa_circ_0083756 may serve as a potential therapeutic target for the treatment of IVDD.
genetics_knock down_suppress	35187630	hsa-mir-223	Carcinoma, Hepatocellular	CONCLUSION: Hsa_circ_0048674 knockdown decelerated HCC progression through the mediation of the miR
circulation_biomarker_diagnosis_ns	35187084	hsa-mir-483	Sepsis	Conclusion: The present study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and the utility of combining miR
circulation_biomarker_diagnosis_ns	35187084	hsa-let-7d	Sepsis	Conclusion: The present study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and the utility of combining miR
genetics_overexpression_suppress	35187068	hsa-mir-125b	Adenocarcinoma of Lung	Moreover, in vitro experiments indicated that the overexpression of miR-125b-5p significantly inhibited cell proliferation, migration, and invasion and induced cell apoptosis of LUAD.
target gene	35187064	hsa-mir-130a	Rhabdomyosarcoma	Down-Regulated miR-130a/b Attenuates Rhabdomyosarcoma Proliferation via PPARG.
target gene	35187064	hsa-mir-130b	Rhabdomyosarcoma	Down-Regulated miR-130a/b Attenuates Rhabdomyosarcoma Proliferation via PPARG.
other	35186962	hsa-mir-199a	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-199a	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-133a	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-27a	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-222	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-27a	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-222	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-133a	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-486	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-221	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-214	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-221	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-214	Critical Illness	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
other	35186962	hsa-mir-486	COVID-19	3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared.
transcription factor target	35186915	hsa-mir-205	Myocardial Reperfusion Injury	Bioinformatics analyses and luciferase, pull-down, and RNA-binding immunoprecipitation assays further revealed that lncAABR07025387.1 interacted with miR-205, which directly targeted ACSL4, a known contributor to ferroptosis. These findings suggest that, mechanistically, lncAABR07025387.1 negatively regulates miR-205 expression and subsequently upregulates ACSL4-mediated ferroptosis.
transcription factor target	35186909	hsa-mir-16	Bone Diseases	Thus, Mg-HA-C/C composites promote osteogenic differentiation and repair bone defects through inhibiting miR-16.
other	35186758	hsa-mir-934	pancreatic adenocarcinoma	To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients.
other	35186758	hsa-mir-4444-2	pancreatic adenocarcinoma	To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients.
other	35186758	hsa-mir-655	pancreatic adenocarcinoma	To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients.
other	35186758	hsa-mir-1301	pancreatic adenocarcinoma	To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients.
lncRNA target	35186455	hsa-mir-128	Pancreatic Carcinoma	3p inhibitor in AsPC-1 cells.
circulation_biomarker_prognosis_up	35186240	hsa-mir-1254	Uterine Cervical Neoplasms	ABHD11-AS1 decreased and miR-1254 increased in serum of cervical carcinoma patients after treatment (P < 0.05).
lncRNA target	35186236	hsa-mir-511	Breast Neoplasms	5p was a biomarker event for breast cancer, and CCNE1 and CHEK1 served as potential targets of miR
transcription factor target	35186224	hsa-mir-221	Sepsis	This experiment mainly discusses the effect of miR-221 on acute liver and kidney injury in septic rats. CONCLUSION: MiR-221 promotes the expression of HECTD2 in septic rats, and inhibition of miR-221 expression can reduce the degree of liver and kidney injury in septic rats.
lncRNA target	35186188	hsa-mir-488	Cardiotoxicity	3p/CyclinG1 as therapeutic targets in doxorubicin-induced cardiovascular diseases.
other	35186170	hsa-mir-7152	Carcinoma, Hepatocellular	AC007099.1/miR-7152/FAP was found to be associated with immune infiltration in patients with hepatocellular carcinoma.
circRNA target	35186081	hsa-mir-1290	Stomach Neoplasms	CONCLUSION: circACVR2A competitively sponged miR-1290 and was exerted as a tumor suppressor gene oncogene via a circACVR2A/miR-1290 axis, suggesting it as a possible biomarker for GC therapy.
lncRNA target	35186067	hsa-mir-1301	Liver Neoplasms	The purpose of this article is to use an improved CNN neural network model algorithm combined to contrast the experimental groups and use deep learning medical imaging technology to study the mechanism by which miR-1301 inhibits the proliferation of carcinoma YD-38 cells through the PI3K/AKT pathway.
other	35186067	hsa-mir-1	Liver Neoplasms	3p on the proliferation ability of liver cancer cells.
target gene	35185415	hsa-mir-873	Uterine Cervical Neoplasms	MiRNA-873-5p Acts as a Potential Novel Biomarker and Promotes Cervical Cancer Progression by Regulating ZEB1 via Notch Signaling Pathway.
circulation_biomarker_diagnosis_ns	35185369	hsa-mir-21	Lung Allograft Dysfunction	Circulating miR-21 was determined in collected serum samples of CLAD and matched stable recipients.
other	35185288	hsa-mir-139	Stomach Neoplasms	hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells.
transcription factor target	35185286	hsa-mir-21	Bone Diseases	Collectively, our findings suggested that high-magnitude mechanical strain affected osteoclastic differentiation through modulating the miR-21/PTEN/PI3K/Akt signaling cascade, which provided potential strategies for the treatment of bone-related diseases.
genetics_knock down_promote	35184918	hsa-mir-877	Keloid	5p on the biological functions of keloid fibroblasts could be abolished by EGR1 overexpression.
circulation_biomarker_diagnosis_ns	35184688	hsa-mir-552	Diabetes Mellitus, Type 2	3pin the serum of T2DM patients.
genetics_overexpression_promote	35184686	hsa-mir-144	Thyroid Neoplasms	5p overexpression enhanced the anti-tumor effect of PTX on thyroid carcinoma by targeting STON2.
genetics_knock down_suppress	35184666	hsa-mir-149	Inflammation	LINC00917 knockdown restored NPC cellular functions and inhibited IDD progression by modulating the miR5p/NLRP1 axis.
genetics_knock down_suppress	35184666	hsa-mir-149	Syphilis	LINC00917 knockdown restored NPC cellular functions and inhibited IDD progression by modulating the miR5p/NLRP1 axis.
genetics_overexpression_suppress	35184646	hsa-mir-378a	Carcinoma, Hepatocellular	Furthermore, the overexpression of miR-378a-3p hindered cell proliferation and migration but facilitated apoptosis by repressing STAT3 signaling in HCC cells.
genetics_overexpression_suppress	35184643	hsa-mir-489	Retinoblastoma	3p overexpression, respectively.
genetics_knock down_promote	35184456	hsa-mir-1290	Endometrial Neoplasms	Knockdown of miR1290 expression can promote the proliferation of endometrial cancer cells, but inhibit cell invasion, migration and EMT ability through the PI3K/Akt and Wnt/beta-catenin pathways.
lncRNA target	35184431	hsa-mir-22	Dementia	5p alleviates vascular dementia development by targeting TSPAN5.
lncRNA target	35184431	hsa-mir-22	Dementia, Vascular	5p alleviates vascular dementia development by targeting TSPAN5.
genetics_overexpression_promote	35184427	hsa-mir-21	Vascular Calcification	Our results suggest that overexpression of miR
genetics_overexpression_promote	35184427	hsa-mir-21	Kidney Failure, Chronic	Our results suggest that overexpression of miR
genetics_overexpression_promote	35184139	hsa-mir-483	Acute Kidney Injury	5p directly targeted to GPX3, overexpression of which rescued cisplatin-induced AKI by inhibiting oxidative stress and apoptosis of tubular cells, but not by regulating autophagy.
lncRNA target	35184134	hsa-mir-124	Stomach Neoplasms	These results primarily demonstrated TGF-beta1 can regulate cancer cell migration, invasion and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC.
other	35184133	hsa-mir-486	Attention Deficit Disorder with Hyperactivity	5p showed differential trends of DeltaCt values between treatment responders and non-responders.
other	35184133	hsa-mir-27a	Attention Deficit Disorder with Hyperactivity	5p showed differential trends of DeltaCt values between treatment responders and non-responders.
other	35184133	hsa-mir-140	Attention Deficit Disorder with Hyperactivity	5p showed differential trends of DeltaCt values between treatment responders and non-responders.
transcription factor target	35183672	hsa-mir-345	Liver Injury	5p, and miR-30e-5p might be involved in CdCl(2)-induced liver injury, in part by dysregulation of lipid metabolism and inflammation.
transcription factor target	35183672	hsa-mir-34a	Liver Injury	5p, and miR-30e-5p might be involved in CdCl(2)-induced liver injury, in part by dysregulation of lipid metabolism and inflammation.
circulation_biomarker_diagnosis_up	35183243	hsa-mir-205	Ovarian Neoplasms	CONCLUSION: The level of miR-205 in plasma exosomes is a valuable tumor biomarker to improve OC diagnosis.
lncRNA target	35183226	hsa-mir-5586	Pancreatic Carcinoma	Moreover, our data revealed that YTHDF3 was a critical target for miR5p, by which forming a negative feedback with DICER1-AS1 to regulate glycolysis of PC.
other	35183135	hsa-mir-6815	Adenocarcinoma of Lung	CONCLUSIONS: This study, for the first time, deciphered the regulatory role of FENDRR/miR5p axis in the progression of early-stage LUAD, which is needed to be established in vitro and in vivo.
other	35183057	hsa-mir-93	Stomach Neoplasms	Mechanistically, we demonstrated that GPC5-AS1 stabilizes GPC5 mRNA by acting as a molecular sponge for miR-93 and miR-106a, thereby reducing GC tumor progression.
other	35183057	hsa-mir-106a	Stomach Neoplasms	Mechanistically, we demonstrated that GPC5-AS1 stabilizes GPC5 mRNA by acting as a molecular sponge for miR-93 and miR-106a, thereby reducing GC tumor progression.
transcription factor target	35183007	hsa-mir-214	Cardiomegaly	CONCLUSIONS: Collectively, these findings indicate that FTZ is a protective factor for cardiac hypertrophy due to its regulation of the miRSIRT3 axis, which suggests that FTZ may be a therapeutic target for cardiac hypertrophy.
transcription factor target	35183007	hsa-mir-214	Atherosclerosis	CONCLUSIONS: Collectively, these findings indicate that FTZ is a protective factor for cardiac hypertrophy due to its regulation of the miRSIRT3 axis, which suggests that FTZ may be a therapeutic target for cardiac hypertrophy.
lncRNA target	35182679	hsa-mir-431	Carcinoma, Pancreatic Ductal	5p acts as a tumour suppressor in PDAC cells, with BxPC-3 cells being most responsive.
genetics_overexpression_promote	35182329	hsa-mir-378b	Hemangioma, Cavernous	Moreover, FOLS1 was the target of miR-378b, and its overexpression reversed the inhibitory effect of miR-378b overexpression on IH cell tumor-like behaviors in vitro.
target gene	35182064	hsa-mir-181a	Leukemia, Myeloid, Acute	The Inhibitory Effect of Sulforaphane on The Proliferation of Acute Myeloid Leukemia Cell Lines through Controlling miR-181a.
other	35182062	hsa-mir-29a	Diabetic Nephropathies	There was a decrease in miRNA-377 (P<0.01) and increase in miRNA-29a (P<0.001) in the diabetic rats.
other	35182062	hsa-mir-377	Diabetic Nephropathies	There was a decrease in miRNA-377 (P<0.01) and increase in miRNA-29a (P<0.001) in the diabetic rats.
other	35182016	hsa-mir-124	Alzheimer Disease	MicroRNA-124 (miR-124) is the most abundant miRNA in the normal brain with great potency to ameliorate AD-like pathology, while it is deficient in AD brain. Herein, the authors develop a DNA nanoflowers (DFs)-based delivery system to realize exogenous supplementation of miR-124 for AD therapy.
other	35181997	hsa-mir-137	Aortic Diseases	Increases in miR-34a and miR-137 with ageing downregulate the expression of Src and paxillin, leading to impaired ERK signalling and aortic contractile dysfunction.
other	35181997	hsa-mir-34a	Aortic Diseases	Increases in miR-34a and miR-137 with ageing downregulate the expression of Src and paxillin, leading to impaired ERK signalling and aortic contractile dysfunction.
transcription factor target	35181869	hsa-mir-139	Adenocarcinoma of Lung	Mechanistically, miR5p might negatively regulate CCNB1 in LUAD, thereby suppressing cell proliferation, migration, invasion and cell cycle.
circRNA target	35181843	hsa-mir-361	Ovarian Neoplasms	RAB1A was a downstream target of miR
circulation_biomarker_diagnosis_ns	35181820	hsa-mir-92a	Infertility	Elevated expression of miR-92a-3p in post-pubertal testes results into functionally compromised Sc, leading to impairment of the blood-testis barrier formation and apoptosis of pre-meiotic Gc, ultimately culminating into infertility.
other	35181820	hsa-mir-92a	Infertility, Male	Collectively, our data suggest that regulation of miR-92a-3p expression is crucial for Sc-mediated induction of active spermatogenesis at puberty and regulation of male fertility.
circRNA target	35181624	hsa-mir-485	Carcinoma, Non-Small-Cell Lung	5p plays a crucial role in the progression of non-small cell lung cancer by regulating HSP90 function, thereby may be an inhibition therapeutic target of non-small cell lung cancer.
other	35181620	hsa-mir-126	Carcinoma, Hepatocellular	Also, we detected a low expression level of miR-126 in HCC and CCA cell lines.
circulation_biomarker_diagnosis_up	35181618	hsa-mir-142	Osteoporosis	METHODS: Clinical serum samples collected from 30 osteoporosis patients were utilized to obtain circ_0006873 and miR
genetics_overexpression_suppress	35181613	hsa-mir-654	Wilms Tumor	Overexpression of miR
circulation_biomarker_diagnosis_ns	35181587	hsa-mir-371a	Testicular Neoplasms	3p nor miR-371a-3p are suitable as circulating teratoma markers.
circulation_biomarker_diagnosis_up	35180915	hsa-mir-124	Cerebral Infarction, Lacunar	MSN-encapsulated miR-124 inhibitor increased the expression of SCF/c-kit protein by targeting P2Y(12), thereby enhancing regeneration of cerebral blood vessels in LCI.
lncRNA target	35180913	hsa-mir-455	Myocardial Infarction	5p significantly inhibited the expression of SOCS3 and resulted in the increased protection of cells damaged by H(2)O(2), which was used as a model of myocardial infarction.
transcription factor target	35180673	hsa-mir-18b	Shock, Hemorrhagic	MiR-18b-5p was highly expressed in the spleen of hemorrhagic shock rats detected by the qRT-PCR assay. Taken together, miR-18b-5p may be a novel therapeutic candidate target in splenic hemorrhagic shock treatment.
circRNA target	35180547	hsa-mir-299	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our present findings first demonstrate that circ_OSBPL10 can regulate the functional behaviors of OSCC cells at least partially by miR3p/CDK6 axis, highlighting circ_OSBPL10 as a promising therapeutic target for OSCC.
lncRNA target	35180020	hsa-mir-34a	Cataract, Age-Related Nuclear	PURPOSE: MiR-34a-5p is reported to be related with age-related nuclear cataract. These data suggest that miR-34a-5p may be a potential novel therapeutic target for the prevention and treatment of age-related cataract.
lncRNA target	35180001	hsa-mir-203a	Osteoarthritis	We elucidated how maclurin promotes the chondrogenic differentiation of BMSCs by regulating miR-203a-3p/Smad1, which provides a strategy for future exploration of osteoarthritis therapy through cell transplantation.
lncRNA target	35179718	hsa-mir-9	Triple Negative Breast Neoplasms	5p/LZTS2 axis may be a novel biomarker and therapeutic target for TNBC patients.
genetics_overexpression_promote	35179516	hsa-mir-154	Hepatoblastoma	3p inhibitor and ROCK1 overexpression were able to reverse the effect of downregulated Linc00205 on proliferation, migration, invasion, and apoptosis of HB cells by rescue assays via mitogen-activated protein kinase (MAPK) signaling.
circulation_biomarker_diagnosis_up	35179443	hsa-mir-181	Diabetic Retinopathy	CONCLUSIONS: MiR-181 is upregulated in plasma and aqueous humor of DR patients.
genetics_knock down_promote	35179434	hsa-mir-545	Ovarian Neoplasms	Gain- and loss-of functions of circ_0067934, miR
genetics_knock down_promote	35179324	hsa-mir-155	Cancer-Associated Cachexia	Moreover, overexpression of miR-155 in GC exosomes improved CAC in vivo, which was characterized by fat loss, suppressed expressions of C/EPB, C/EPB, and PPAR in A-MSCs, and high expression of UCP1 (P &lt; 0.05).
genetics_knock down_promote	35179324	hsa-mir-155	Stomach Neoplasms	Moreover, overexpression of miR-155 in GC exosomes improved CAC in vivo, which was characterized by fat loss, suppressed expressions of C/EPB, C/EPB, and PPAR in A-MSCs, and high expression of UCP1 (P &lt; 0.05).
circRNA target	35179220	hsa-mir-182	Kidney Neoplasms	Overall, the circKL/miR1825p/FBXW7 axis was indicated to have a key role in the growth and metastasis of kidney cancer and may be targeted as a novel therapeutic strategy.
other	35178994	hsa-mir-17	Atherosclerosis	astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway
lncRNA target	35178162	hsa-mir-423	Osteochondritis Dissecans	It was concluded that HBO attenuated NSC pyroptosis via lncRNA-H19/miR
circulation_biomarker_diagnosis_up	35178127	hsa-mir-125a	Depression	Small RNA sequencing revealed 11 deregulated circulating miRNAs in MDD and BD plasma, of which expression of 5, hsa-miR
circulation_biomarker_diagnosis_up	35178127	hsa-let-7e	Depression	Small RNA sequencing revealed 11 deregulated circulating miRNAs in MDD and BD plasma, of which expression of 5, hsa-miR
circulation_biomarker_diagnosis_up	35177926	hsa-mir-139	Colonic Neoplasms	RESULTS: Compared with control group, significantly lower expression level of serum miR
tissue_expression_ns	35177192	hsa-mir-21	Myocardial Infarction, Acute	MZB cell deficiency and MZB cell-specific deletion of miR21 or Hif1a improved cardiac function after acute MI.
other	35177076	hsa-mir-423	Polycystic Ovary Syndrome	RESULTS: Circ_FURIN and MTM1 expressions were significantly upregulated, whereas miR5p was downregulated in the ovarian cortex tissues of PCOS patients and TTR-treated KGN cells compared with controls.
lncRNA target	35177060	hsa-mir-497	Poikiloderma with Neutropenia	CONCLUSIONS: GAS promotes the recovery of PNI via modulating miR-497 / BDNF axis and inhibiting oxidative stress.
lncRNA target	35177003	hsa-mir-214	Atherosclerosis	5p/COX20 axis, suggesting that DANCR might be a potential therapeutic target for AS.
lncRNA target	35176945	hsa-mir-143	Nasopharyngeal Carcinoma	It is concluded that the down-regulated LHFPL3-AS1 retards the development of radiation-resistant NPC cells via sponging miR
genetics_knock down_promote	35176937	hsa-mir-633	Colorectal   Adenocarcinoma	Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis.
other	35176332	hsa-mir-34a	Head and Neck Neoplasms	Profiling of the radiation response in the UM-SCC-1 head and neck cancer cell line confirmed reduced metabolic activity and increased radiation induced apoptosis upon treatment with miR-34a-HDL NPs. The radio-sensitising properties of miR-34a-HDL NPs were further confirmed in a more biologically relevant co-culture spheroid model of head and neck cancer.
lncRNA target	35176309	hsa-mir-373	Pancreatic Carcinoma	PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer.
lncRNA target	35176309	hsa-mir-373	Muscular Atrophy	PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer.
circulation_biomarker_diagnosis_ns	35175475	hsa-mir-221	Breast Neoplasms	We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer.
circulation_biomarker_diagnosis_ns	35175475	hsa-mir-429	Breast Neoplasms	We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer.
circulation_biomarker_diagnosis_ns	35175475	hsa-mir-222	Breast Neoplasms	We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer.
circulation_biomarker_diagnosis_ns	35175475	hsa-mir-21	Breast Neoplasms	We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer.
other	35175428	hsa-mir-491	Glioblastoma	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-485	Glioblastoma	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-1290	Brain Neoplasms	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-491	Brain Neoplasms	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-485	Brain Neoplasms	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-338	Brain Neoplasms	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-338	Glioblastoma	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-21	Glioblastoma	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-21	Brain Neoplasms	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35175428	hsa-mir-1290	Glioblastoma	5p and hsa-miR-1290, were solely associated to glioblastoma.
other	35174774	hsa-mir-197	Glioma	3p/CKS1B axis, highlighting a novel competing endogenous RNA circuit of glioma progression.
lncRNA target	35174753	hsa-mir-130b	Osteoarthritis	CONCLUSION: This study provided evidence that EVs alleviate chondrocyte damage during OA through miR-130b-3p-mediated inhibition of the LRP12/AKT/beta-catenin axis.
circRNA target	35174654	hsa-mir-1299	Breast Neoplasms	CONCLUSIONS: Circ_0001955 was found to promote breast cancer malignant development via targeting of the miR-1299/GLUT1 pathway, which contributes to our understanding of the pathogenesis of breast cancer.
other	35174434	hsa-mir-122	Hypertension	5p exacerbates myocardial fibrosis and dysfunction in hypertensive rats by modulating the elabela/apelin-ACE2-GDF15 signaling.
other	35174434	hsa-mir-122	Myocardial Fibrosis	5p exacerbates myocardial fibrosis and dysfunction in hypertensive rats by modulating the elabela/apelin-ACE2-GDF15 signaling.
lncRNA target	35174294	hsa-mir-25	Reperfusion Injury, Renal Ischemia	3p may target DKK3 to reduce renal cell damage caused by hypoxia and that miR
other	35174066	hsa-mir-1269a	Carcinoma, Hepatocellular	Survival analysis of clinical samples showed that hsa-mir-1269a, hsa-mir-421 were associated with prognosis (p<0.05).This study revealed the general expression characteristics of specific differentially expressed miRNAs using a ceRNA network constructed from HCC samples.
other	35174066	hsa-mir-421	Carcinoma, Hepatocellular	Survival analysis of clinical samples showed that hsa-mir-1269a, hsa-mir-421 were associated with prognosis (p<0.05).This study revealed the general expression characteristics of specific differentially expressed miRNAs using a ceRNA network constructed from HCC samples.
circulation_biomarker_diagnosis_up	35173872	hsa-mir-384	Spinal Cord Injuries	OBJECTIVE: To explore the mechanism of circ_014260 regulating neuronal apoptosis, oxidative stress, and endoplasmic reticulum stress in rats with spinal cord injury (SCI) via miR-384/THBS1 axis.
circulation_biomarker_prognosis_ns	35173845	hsa-mir-124	Brain Injuries	OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis.
circulation_biomarker_prognosis_ns	35173845	hsa-mir-124	Craniocerebral Trauma	OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis.
circulation_biomarker_prognosis_ns	35173845	hsa-mir-210	Craniocerebral Trauma	OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis.
circulation_biomarker_prognosis_ns	35173845	hsa-mir-210	Brain Injuries	OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis.
genetics_overexpression_promote	35173840	hsa-mir-1179	Carcinoma, Hepatocellular	Overexpression of NUAK2 can reverse the effect of miR-1179 on hepatocellular carcinoma cells.
genetics_overexpression_promote	35173832	hsa-mir-122	Fibrosis, Renal	5p or overexpression of PKM could promote apoptosis of TGF-beta1-treated HK2 cells, inhibit their viability, aggravate fibrosis, and attenuate the protective effect of RR on the cells.
other	35173821	hsa-mir-532	Prostatic Diseases	5p showed a significant differential expression within the group of patients with PCa in a training subset of the data containing 32 patients.
other	35173821	hsa-mir-6749	Prostatic Diseases	5p showed a significant differential expression within the group of patients with PCa in a training subset of the data containing 32 patients.
other	35173610	hsa-mir-342	Carcinoma, Hepatocellular	Rescue assays validated the LINC01134/miR3p/MAPK1 axis in the radio-resistant HCC cells.
transcription factor target	35173533	hsa-mir-484	dystonia 5	We found that miR-484 was highly expressed in GCs from DOR patients and was correlated with decreasing AMH levels and AFC, as well as increasing FSH levels, but not with LH, progesterone, or estradiol. The present study indicates that miR-484 can directly target the mRNA of YAP1, induce mitochondrial dysfunction, and consequently reduce the viability and promote the apoptosis of granulosa cells, which contributes to the pathogenesis of DOR.
transcription factor target	35173533	hsa-mir-484	Mitochondrial Diseases	Moreover, we found that miR-484 repressed the proliferation of GCs and induced apoptosis, which can in part be attributed to mitochondrial dysfunction. The present study indicates that miR-484 can directly target the mRNA of YAP1, induce mitochondrial dysfunction, and consequently reduce the viability and promote the apoptosis of granulosa cells, which contributes to the pathogenesis of DOR.
lncRNA target	35173533	hsa-mir-484	Corneal dystrophy, epithelial basement membrane	Multiple approaches, including bioinformatic analysis, RNA-seq, qPCR, immunofluorescence, western blotting and luciferase reporter assays, identified YAP1 as a direct target of miR-484 in GCs.
circulation_biomarker_diagnosis_ns	35173476	hsa-mir-155	Hepatitis C	BACKGROUND: To investigate the expression of serum miR-155 and miR-224 among patients with hepatitis C virus (HCV) infection and analyze their clinical values.
circulation_biomarker_diagnosis_ns	35173476	hsa-mir-224	Hepatitis C	BACKGROUND: To investigate the expression of serum miR-155 and miR-224 among patients with hepatitis C virus (HCV) infection and analyze their clinical values.
genetics_overexpression_promote	35173455	hsa-mir-24	Uterine Diseases	CONCLUSION: Our findings demonstrate that the overexpression of miR3p attenuates endometrial inflammation and the expression of pro-inflammatory mediators via suppressing TRAF6.
other	35173455	hsa-mir-24	Endometritis	The present study intends to investigate the regulatory role of miR3p in the innate immune response involved in endometritis and evaluate its therapeutic potential.
lncRNA target	35173453	hsa-mir-155	psoriasis 1	Inhibitions of both TLR4 pathway and miR-155 further corrected abnormalities of proliferation and the above biomarkers in CD14(+) monocytes from psoriatic patients.
exosome	35173168	hsa-let-7	Breast Neoplasms	Moreover, Lin28B-induced breast cancer stem cells are the main sources of low-let-7s exosomes.
lncRNA target	35173146	hsa-mir-374b	Carcinoma, Renal Cell	In conclusion, the circAFAP1/miR-374b-3p/VEGFA axis played a critical role in the progression and development of ccRCC which might be novel biological marks and therapeutical targets.
other	35173110	hsa-mir-363	Acute Lung Injury	3p/S1PR1 axis-mediated protective effect on septic ALI.
genetics_GWAS	35172717	hsa-mir-486	Osteosarcoma	5p represents a highly cancer relevant, epigenetically regulated miRNA in osteosarcoma, and this knowledge contributes to the understanding of osteosarcoma biology.
epigenetics	35172677	hsa-mir-29b	Depression	EZH2 inhibited miR-29b-3p expression by combining with miR-29b-3p promoter and trimethylation of histone H3-lysine 27-trimethylated upregulation, and then elevated MMP2 transcription and triggered microglia M1-type polarization, thus exacerbating depression-like behaviors and neuroinflammation of depression.
circRNA target	35172672	hsa-mir-497	Sepsis	In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI.
circRNA target	35172672	hsa-mir-497	Lung Injury	In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI.
genetics_overexpression_promote	35172671	hsa-mir-15b	spondyloepimetaphyseal dysplasia, Strudwick type	Notably, YAP1 overexpression attenuated the inhibitory effects of miR-15b-5p up-regulation on the proliferation, migration, and inflammatory response, as well as ECM deposition of TNF-alpha-induced ASM cells.
other	35172671	hsa-mir-15b	Asthma	In conclusion, miR-15b-5p/YAP1 axis modulates the growth, migration, inflammatory response, and ECM deposition of ASM cells, thus participating in the pathogenesis of asthma.
genetics_GWAS	35172669	hsa-mir-24	Osteoarthritis	5p/BMPR2 axis.Abbreviations OA: osteoarthritis; BMPR2: bone morphogenetic protein type 2 receptor.
genetics_knock down_promote	35172608	hsa-mir-493	Fibrosis, Renal	Overexpression of circPlekha7 or knockdown of miR
transcription factor target	35172278	hsa-mir-185	Atherosclerosis	5p effectively alleviates atherosclerosis and lipid accumulation by regulating the miR
transcription factor target	35172278	hsa-mir-185	Lipidoses	5p effectively alleviates atherosclerosis and lipid accumulation by regulating the miR
other	35171545	hsa-mir-146a	Arthritis, Rheumatoid	In conclusion, data of this study suggested a possible association between miRNA 146a-5p expression level and the incidence of RA in Egyptian patients.
lncRNA target	35171433	hsa-mir-125	Cerebral Hemorrhage	The present findings demonstrate that IRE1alpha inhibition attenuates mast cells degranulation and neuroinflammation, at least partially, through IRE1alpha/miR-125/Lyn signaling pathway after ICH.
lncRNA target	35171433	hsa-mir-125b-2	Cerebral Hemorrhage	Inhibition of IRE1alpha, with STF083010, remarkably reduced brain water content, improved neurological function, decreased hematoma volume, upregulated the expression of miR-125b3p, decreased the number of mast cells, and downregulated the protein expression of Lyn kinase, XBP1s (spliced X-box binding protein-1), tryptase, IL-17A and TNF-alpha.
genetics_overexpression_promote	35171402	hsa-mir-466	Colorectal Neoplasms	LINC 01436 is overexpressed in CRC and promotes cancer cell proliferation by suppressing miR-466 maturation.
genetics_overexpression_suppress	35171359	hsa-mir-24	Osteosarcoma	3p overexpression inhibited the proliferation and chemoresistance of OS cells.
circulation_biomarker_diagnosis_ns	35171328	hsa-mir-371a	Neoplasms, Germ Cell, Intracranial	CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma.
circulation_biomarker_diagnosis_ns	35171328	hsa-mir-372	Neoplasms, Germ Cell, Intracranial	CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma.
circulation_biomarker_diagnosis_ns	35171328	hsa-mir-367	Neoplasms, Germ Cell, Intracranial	CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma.
transcription factor target	35171066	hsa-mir-29b	Asthma, Severe	OBJECTIVE: To examine the relationship between Nrf2-miR-29b axis and SA, and to detect whether preventive use of GSPE relieves SA via it.
lncRNA target	35171050	hsa-mir-30	Acute Lung Injury	5p/ROCK2 pathway, providing a therapeutic target for ALI.
other	35170486	hsa-mir-23c	Norrie disease	Using quantitative polymerase chain reaction and western blotting, we found that circ-GNB4 and early growth response factor 1 (EGR1) were upregulated, whereas microRNA (miR)-23c was downregulated in DN patients' sera and HG-stimulated HRMCs. Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress.
other	35170486	hsa-mir-23c	Inflammation	Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress.
lncRNA target	35170388	hsa-mir-675	Subarachnoid Hemorrhage	Therefore, the administration of MT increased the levels of H19 and miR-675 which have been inhibited by SAH. Therefore, the treatment with MT could ameliorate post-SAH DBI.Running title: Melatonin ameliorates post-SAH DBI via H19/miR-675/HIF1A/TLR4 signaling pathways.
genetics_overexpression_promote	35170385	hsa-mir-122	Peritoneal Fibrosis	5p overexpression showed a deterioration effect on PD-related PF by targeting Smad5 to activate Wnt/beta-catenin pathway.
lncRNA target	35170375	hsa-mir-421	Inflammation	Up-regulation of miR-421 or down-regulation of XIAP could reverse the suppressive effects of SNHG16 on OS and cell inflammation.
target gene	35170374	hsa-mir-1299	Stomach Neoplasms	Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.
genetics_overexpression_promote	35170372	hsa-mir-140	Carcinoma, Non-Small-Cell Lung	Overexpression of HOXB5 mitigated miR
genetics_GWAS	35170354	hsa-mir-137	Alzheimer Disease	Aims: In this study, the authors hypothesized that, in an in vitro Alzheimer's disease model, the epigenetic axis of SNHG19/hsa-miR-137 functionally regulates amyloid beta peptide 25-35 (Abeta(25-35))-induced SH-SY5Y cytotoxicity. Conclusions: The authors concluded that the epigenetic axis of SNHG19/hsa-miR-137/TNFAIP1 may functionally regulate Abeta(25-35)-induced SH-SY5Y cytotoxicity, thus making it a potential molecular target for Alzheimer's disease treatment.
circRNA target	35170199	hsa-mir-34c	Carcinoma, Hepatocellular	Mechanistically, Circ_0003945 might exert as a miR-34c-5p sponge to upregulate the expression of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), activating the beta-catenin pathway, and finally facilitating HCC progression. In conclusion, Circ_0003945 exerts a tumour-promoting role in HCC cells by regulating the miR-34c-5p/LGR4/beta-catenin axis, which may be a potential target for HCC therapy.
genetics_knock down_suppress	35169903	hsa-mir-597	Carcinoma, Hepatocellular	5p was demonstrated to function in HCC progression by targeting TEAD1 via TEAD1 expression gain and loss.
genetics_knock down_promote	35169864	hsa-mir-497	Breast Neoplasms	By contrast, knockdown of DDX11AS1 expression inhibited PTX resistance of breast cancer cells, and suppressed the proliferation, invasion and migration of breast cancer cells, which was achieved via upregulation of miR497 expression. In conclusion, knockdown of lncRNA DDX11AS1 could inhibit the proliferation, migration and PTX resistance of breast cancer cells by upregulating miR497 expression.
other	35169383	hsa-mir-146	Prediabetic State	CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes.
other	35169383	hsa-mir-126	Prediabetic State	CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes.
other	35169383	hsa-mir-15	Prediabetic State	CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes.
other	35169383	hsa-mir-146a	Prediabetic State	CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes.
circulation_biomarker_diagnosis_ns	35169355	hsa-mir-21	Prostatic Neoplasms	CONCLUSION: miRNA-21 could serve as biomarkers of prostate cancer progressivity since remarkable diagnostic value of circulating miRNA-21 in prostate cancer metastasis process.
lncRNA target	35168722	hsa-mir-122	Liver Injury	Herein, by coupling the target sequence recycling with the primer exchange reaction (PER), a highly sensitive and non-label approach is constructed to detect miRNA-122, the biomarker for drug-induced liver injury.
genetics_knock down_promote	35168653	hsa-mir-1294	Uterine Cervical Neoplasms	CONCLUSION: CircCDK17 knockdown repressed cell proliferation, migration, invasion and glycolysis, and promoted cell apoptosis via miR-1294/YWHAZ axis in CC.
lncRNA target	35168644	hsa-mir-92a	Ovarian Neoplasms	Inhibited OIP5-AS1 or downregulated ITGA6 or elevated miR-92a repressed EMT, viability, migration and invasion, and promoted apoptosis of OC cells.
genetics_knock down_promote	35168468	hsa-mir-383	Colorectal Neoplasms	Interfering with miR-383 expression reversed the inhibitory effect of circ_0068464 knockdown on CRC cells.
other	35168080	hsa-mir-377	Acute Kidney Injury	CONCLUSION: This study suggested that mmu_circ_0000943 participated in progression of renal IRI by sponging miR3p with Egr2, providing a new insight into AKI treatment.
genetics_knock down_suppress	35167942	hsa-mir-28	Alzheimer Disease	Moreover, BACE1 overexpression aggravated neuron injury and inflammation, as well as attenuated the effect of miR-328 overexpression on these functions in cellular AD models.
genetics_GWAS	35167433	hsa-mir-4429	Carcinoma, Non-Small-Cell Lung	Additionally, miR-4429 is associated with EGFR mutation in NSCLC patients.
lncRNA target	35167383	hsa-mir-143	Thyroid Cancer, Papillary	Conclusion: The present results suggest that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR3p/SLC7A11 signaling in renal cancer.
lncRNA target	35167383	hsa-mir-143	Carcinoma, Renal Cell	Conclusion: The present results suggest that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR3p/SLC7A11 signaling in renal cancer.
genetics_knock down_promote	35167195	hsa-mir-636	Lung Neoplasms	CONCLUSION: Circ_0010235 knockdown inhibited lung cancer progression and increased antitumor immunity by regulating the miR-636/PDL1 axis.
genetics_knock down_promote	35166986	hsa-mir-423	Ovarian Neoplasms	Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR
other	35166984	hsa-mir-145	Ovarian Neoplasms	Furthermore, the miR5p/ELF2 axis was involved in the regulation of PRNCR1 in OC progression in vivo.
genetics_overexpression_promote	35166647	hsa-mir-363	Colorectal Neoplasms	3p was markedly under-expressed in CRC tissues and cells, and its overexpression suppressed the viability, migration, and invasion of CRC cells, and promoted cell apoptosis, whereas inhibiting miR
genetics_knock down_promote	35166635	hsa-mir-661	Osteosarcoma	The suppression of circ_0016347 impeded proliferation, migration, invasion, and cell cycle and induced apoptosis in osteosarcoma cells, which was overturned by knockdown of miR-661.
genetics_knock down_promote	35166634	hsa-mir-545	Carcinoma, Pancreatic Ductal	3p mimicked the effects of circ_0072088 knockdown in PDAC cell in vitro.
other	35166206	hsa-mir-188	Lung Neoplasms	Further research to explore the potential therapeutic value of miR5p, both as a biomarker and as a drug candidate for the management of metastatic lung cancer may be warranted.
lncRNA target	35166173	hsa-mir-122	Diabetic Nephropathies	5p suppressed the expression of factor inhibiting hypoxia-inducible factor-1 (FIH-1) in vitro models of DN.
genetics_knock down_promote	35166172	hsa-mir-654	Uterine Cervical Neoplasms	Hence, circRNA_0000285 knockdown suppressed cell viability and promoted apoptosis by targeting miR
lncRNA target	35166074	hsa-mir-205	Rotator Cuff Injuries	OBJECTIVES: To investigate the function and mechanism of miR-205/MeCP2 pathway on the proliferation, migration and fibrosis of rotator cuff tenocytes, in order to provide a new perspective on the repair of rotator cuff tear injury. CONCLUSIONS: The inhibition of MECP2 reversed the effect of miR-205 inhibitor on tenocytes, including the proliferation and migration of tenocytes, indicating that miR-205 may be valuable in miRNA-based therapies for rotator cuff injury.
other	35166053	hsa-mir-516a	Carcinoma, Non-Small-Cell Lung	Our newly identified RNASEH1-AS1/miR-516a-5p/FOXK1/Wnt/beta-catenin network may offer an interesting foundation for NSCLC treatment in the clinic.
circRNA target	35166026	hsa-mir-6751	Lung Neoplasms	CONCLUSION: Circ_0002360 targeted miR3p to regulate ZNF300 level, thus elevating DDP resistance and promoting the malignant progression of lung cancer cells.
other	35166006	hsa-mir-34	Nerve Degeneration	Reduced Utx activity enhanced neurodegeneration and mimicked the protein accumulation seen in miR-34 mutant brains.
other	35165827	hsa-mir-361	Myocardial Infarction	3p.
transcription factor target	35165827	hsa-mir-361	Heart Diseases	This study revealed that miR3p has a cardioprotective effect on hypoxia-induced cardiomyocyte injury, suggesting it may be a novel therapeutic target for hypoxia-related cardiac diseases.
genetics_knock down_suppress	35165827	hsa-mir-361	Hypoxia	3p overexpression markedly reduced hypoxia-induced cardiomyocyte injury; however, its downregulation had an opposite effect.
transcription factor target	35165519	hsa-mir-193a	Carcinoma, Hepatocellular	These findings revealed an important role of Mig-6 in the apoptosis and autophagy of HCC cells by regulating miR-193a-3p, providing a novel insight into the therapeutic target in HCC.
transcription factor target	35165511	hsa-mir-25	Carcinoma, Hepatocellular	Therefore, miR-25 may represent a novel therapeutic target for the treatment of HCC.
other	35165388	hsa-mir-192	non-alcoholic steatohepatitis	Overall, our data highlights the central role of Dicer-associated miR3p in the etiopathogenesis of macrophage M1 polarization in NASH and HCC.
other	35165388	hsa-mir-192	Carcinoma, Hepatocellular	Overall, our data highlights the central role of Dicer-associated miR3p in the etiopathogenesis of macrophage M1 polarization in NASH and HCC.
virus_miRNA	35165282	ebv-mir-BART17	stomach carcinoma	EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC.
virus_miRNA	35165282	ebv-mir-BART11	stomach carcinoma	EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC.
virus_miRNA	35165282	ebv-mir-BART17	Nasopharyngeal Carcinoma	EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC.
virus_miRNA	35165282	ebv-mir-BART11	Nasopharyngeal Carcinoma	EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC.
genetics_overexpression_promote	35165280	hsa-mir-652	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	In our previous studies, we found that overexpression of the ARRB1-derived miR-223 sponge repressed T-ALL progress and reduced the expression of miR
genetics_knock down_promote	35164998	hsa-mir-155	psoriasis 1	mediated regulation of glycolysis, changes in glycolysis were assessed in psoriatic MSC (PM) with either overexpression or knockdown of TP53INP1, or activation/inhibition of p53 signaling pathway.
genetics_overexpression_promote	35164979	hsa-mir-345	Lymphoma, Large B-Cell, Diffuse	RESULTS: Silencing of lncRNA NORAD and overexpression of miR
lncRNA target	35164915	hsa-mir-1226	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: miR-1226, which was regulated by ASCL1, inhibited tumor growth and migration by targeting FGF2, indicating that the ASCL1/miR-1226/FGF2 axis could be a potential therapeutic target for NSCLC.
genetics_overexpression_suppress	35164763	hsa-mir-603	Breast Neoplasms	Also, the repressive effects of miR-603 mimic on the malignant behaviors of BC cells were weakened by KIF2A overexpression.
genetics_overexpression_promote	35164743	hsa-mir-378c	gastric adenocarcinoma	Furthermore, it was validated that miR-378c inhibition accelerated STAD cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), while they were suppressed by miR-378c overexpression.
other	35164656	hsa-mir-1298	Arthritis, Rheumatoid	The results illustrated the biological mechanism of OSER1-AS1/miR59/E2F1 axis in RA progression.
genetics_knock down_suppress	35164653	hsa-mir-141	Adenocarcinoma of Lung	3p inhibitor partly abolished the FAM83A-AS1 knockdown-induced inhibition on EMT, cell growth, invasion and migration in LUAD cells.
lncRNA target	35164634	hsa-mir-7	Cognition Disorders	Decreased MEG3 alleviates cognitive dysfunction caused by ISO by targeting miR
lncRNA target	35164480	hsa-mir-939	Inflammatory Bowel Diseases	Therefore, from the experimental results, it can be concluded that using miR-939 and miR-376a to trap NF-kappaB and NFAT inhibits the activation of transcription factors NF-kappaB and NFAT, which in turn inhibits the expression of inflammatory factors and results in partial recovery of the intestinal barrier in UC.
lncRNA target	35164480	hsa-mir-376a	Inflammatory Bowel Diseases	Therefore, from the experimental results, it can be concluded that using miR-939 and miR-376a to trap NF-kappaB and NFAT inhibits the activation of transcription factors NF-kappaB and NFAT, which in turn inhibits the expression of inflammatory factors and results in partial recovery of the intestinal barrier in UC.
lncRNA target	35163809	hsa-mir-760	cone-rod dystrophy 6	CK2alpha pathway plays essential roles in senescence and CR, thereby suggesting that KCNQ1OT1 is a novel therapeutic target for an alternative treatment that mimics the effects of anti-aging and CR.
circRNA target	35163797	hsa-mir-10391	Influenza, Human	The results of this study suggested that TCONS_00166432 and novel_circ_0004733 could competitively bind miR-10391 to target the MAN2A1 gene to regulate swine influenza virus infecting 3D4/21 cells.
lncRNA target	35163786	hsa-mir-132	Inflammation	3p might participate in inflammation and PGE2 release via targeting DUSP9-dependent p38 and JNK signaling pathways to cause preterm birth.
lncRNA target	35163786	hsa-mir-132	Premature Birth	3p might participate in inflammation and PGE2 release via targeting DUSP9-dependent p38 and JNK signaling pathways to cause preterm birth.
transcription factor target	35163707	hsa-mir-196a	Lung Neoplasms	In this study, we found that miR-196a expression was greatly induced in gefitinib-resistant lung cancer cells. Our studies identified a new role and mechanism of NRF2/miR-196a/GLTP pathway in TKI resistance and lung tumor development, which may be used as a new biomarker (s) for TKI resistance or as a new therapeutic target in the future.
lncRNA target	35163556	hsa-mir-29a	Carcinoma, Hepatocellular	This study insight into a novel molecular pathway by which miR-29a targeting HIF-1alpha and ANGPT2 counteracts the incidence of HCC development.
epigenetics	35163224	hsa-mir-193a	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. We also identified three miRNA genes (MIR148A, MIR9-1, and MIR193A) that likely regulate EMT-MET reversion in the colonization of PMM.
epigenetics	35163224	hsa-mir-129-2	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-339	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-124	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-107	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-137	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-127	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-34b	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-132	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-1258	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-34c	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-125b-1	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-148a	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. We also identified three miRNA genes (MIR148A, MIR9-1, and MIR193A) that likely regulate EMT-MET reversion in the colonization of PMM.
epigenetics	35163224	hsa-mir-9-1	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. According to the Kaplan-Meier analysis, hypermethylation of several examined miRNA genes was associated with poorer overall survival of OvCa patients, and high methylation levels of MIR130B and MIR9-1 were related to the greatest relative risk of death.
epigenetics	35163224	hsa-mir-375	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-124-2	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
epigenetics	35163224	hsa-mir-130b	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. According to the Kaplan-Meier analysis, hypermethylation of several examined miRNA genes was associated with poorer overall survival of OvCa patients, and high methylation levels of MIR130B and MIR9-1 were related to the greatest relative risk of death.
epigenetics	35163224	hsa-mir-9	Ovarian Neoplasms	Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM.
exosome	35163219	hsa-mir-26a	Prostatic Neoplasms	Additionally, transcriptomic profiling of PCa-EVs revealed the abundance of three microRNAs, miR-26a-5p, miR-27a-3p, and miR-30e-5p involved in the suppression of BMPinduced osteogenesis in vivo, suggesting the critical role of these EV-derived miRNAs in PCa-mediated suppression of osteoblast activity.
exosome	35163219	hsa-mir-27a	Prostatic Neoplasms	Additionally, transcriptomic profiling of PCa-EVs revealed the abundance of three microRNAs, miR-26a-5p, miR-27a-3p, and miR-30e-5p involved in the suppression of BMPinduced osteogenesis in vivo, suggesting the critical role of these EV-derived miRNAs in PCa-mediated suppression of osteoblast activity.
lncRNA target	35163214	hsa-mir-425	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-132	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-135a	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-16	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-26a	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-24	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-mir-124	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
lncRNA target	35163214	hsa-let-7a	Depressive Disorder, Major	Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR
other	35163198	hsa-mir-21	Carcinoma, Pancreatic Ductal	In this study, we investigated the role of miR-21, which is highly expressed in Panc-1 and MiaPaCa-2 PDAC cells in association with CSCs. Our data suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and that miR-21 poses as a novel, functional biomarker for PDAC aggressiveness.
other	35163102	hsa-mir-1	Sveinsson Chorioretinal Atrophy	Muscle-miRNAs (miR-1, -133, -206 and -499) were up-regulated, especially in AA samples, and we identified molecular networks with omics integration.
other	35163102	hsa-mir-338	Sveinsson Chorioretinal Atrophy	Two pairs of genes and miRNAs demonstrated a high-level relationship, and involvement in myogenesis and muscle growth: marcksb and miR-29b in AA, and mmp14b and miR5p in IGF1.
other	35163102	hsa-mir-29b	Sveinsson Chorioretinal Atrophy	Two pairs of genes and miRNAs demonstrated a high-level relationship, and involvement in myogenesis and muscle growth: marcksb and miR-29b in AA, and mmp14b and miR5p in IGF1.
lncRNA target	35163020	hsa-mir-150	Vascular Diseases	5p expression and counteracts the inhibitory effect of miR
transcription factor target	35162959	hsa-mir-16	Heart Diseases	We also find that, in response to tunicamycin-induced ER stress, miR5p suppression decreases apoptosis, inflammation and cardiac damage via activating the ATF6-mediated cytoprotective pathway.
circulation_biomarker_diagnosis_ns	35162959	hsa-mir-16	Dmd-Associated Dilated Cardiomyopathy	Previously, we demonstrated that miR5p is enriched in the plasma of ischemic dilated cardiomyopathy (ICM) patients and promotes ER stress-induced apoptosis in cardiomyocytes in vitro.
transcription factor target	35162959	hsa-mir-16	Heart Injuries	5p might contribute to oxidative stress through ER stress induction and that targeting miR
genetics_overexpression_promote	35162959	hsa-mir-16	Dehydration	5p overexpression promotes oxidative stress in AC16 cardiomyoblasts.
circulation_biomarker_diagnosis_up	35162959	hsa-mir-16	Glycogen Storage Disease Type VI	5p is enriched in the plasma of ischemic dilated cardiomyopathy (ICM) patients and promotes ER stress-induced apoptosis in cardiomyocytes in vitro.
circulation_biomarker_diagnosis_up	35160300	hsa-mir-223	Instent Restenosis	CONCLUSION: Elevated serum level of miRNA-223 might be helpful in predicting the occurrence of ISR.
other	35160257	hsa-mir-511	Head and Neck Neoplasms	3p may be a useful biomarker of nutritional deficiencies in patients subjected to IMRT due to HNC.
circulation_biomarker_diagnosis_ns	35160116	hsa-let-7a	Carcinoma, Non-Small-Cell Lung	In NSCLC patients, lower miR let-7a expression level was observed in tumor tissue compared to serum; however, miR-335 expression level was higher (p < 0.05). Changes in miR-335 and miR let-7a expression levels in the serum exosomes of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression.
circulation_biomarker_diagnosis_ns	35160116	hsa-mir-335	Carcinoma, Non-Small-Cell Lung	In NSCLC patients, lower miR let-7a expression level was observed in tumor tissue compared to serum; however, miR-335 expression level was higher (p < 0.05). Changes in miR-335 and miR let-7a expression levels in the serum exosomes of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression.
circulation_biomarker_diagnosis_ns	35159951	hsa-mir-451a	Malaria	Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases.
circulation_biomarker_diagnosis_ns	35159951	hsa-mir-451a	Anemia, Sickle Cell	Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases.
circulation_biomarker_diagnosis_ns	35159951	hsa-let-7i	Malaria	Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases.
circulation_biomarker_diagnosis_ns	35159951	hsa-let-7i	Anemia, Sickle Cell	Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases.
other	35159373	hsa-mir-21	Pulmonary Arterial Hypertension	Collectively, our study revealed that the upregulation of miR-21 in the early phase (RV hypertrophy) and downregulation in the late phase (RV dysfunction) under PAH triggered a biphasic regulation of cardiac remodeling and cardiomyocyte apoptosis.
other	35159373	hsa-mir-21	Ventricular Dysfunction, Right	Collectively, our study revealed that the upregulation of miR-21 in the early phase (RV hypertrophy) and downregulation in the late phase (RV dysfunction) under PAH triggered a biphasic regulation of cardiac remodeling and cardiomyocyte apoptosis.
lncRNA target	35159335	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR
lncRNA target	35159335	hsa-let-7a	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR
lncRNA target	35159335	hsa-mir-1	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR
lncRNA target	35159335	hsa-mir-708	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR
lncRNA target	35159261	hsa-mir-100	Lipoma	Previously, microRNA-100 (miR-100) and its putative mRNA target, insulin-like growth factor receptor-1 (IGF1R) were identified as differentially and inversely expressed in bovine longissimus dorsi (LD) muscles with divergent intramuscular fat (IMF) content by our group.
genetics_overexpression_promote	35159062	hsa-mir-21	Carcinoma, Renal Cell	First, in a cohort of 52 primary ccRCC samples, using RT-qPCR and immunohistochemistry, we showed that miR-21 overexpression was correlated with PPAR-alpha downregulation.
other	35159038	hsa-mir-151a	Adenocarcinoma of Lung	We specifically investigated an edited miRNA, miR-151a-3p with an A-to-I editing event at position 3, to determine how its altered expression may be associated with activation of divergent biological pathways between W and B/AA LUAD patients.
other	35159038	hsa-mir-151a	Lung Neoplasms	We specifically investigated an edited miRNA, miR-151a-3p with an A-to-I editing event at position 3, to determine how its altered expression may be associated with activation of divergent biological pathways between W and B/AA LUAD patients.
other	35158368	hsa-mir-21	Choroidal Neovascularization	CONCLUSION: miR-21 correlated with HIF-1alpha-VEGF signaling pathway may promote CNV formation in high-myopia guinea.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-145	Diabetes Mellitus, Type 2	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-101	Albuminuria	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-101	Diabetes Mellitus, Type 2	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-874	Diabetes Mellitus, Type 2	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-145	Albuminuria	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_up	35158353	hsa-mir-874	Albuminuria	3p in the serum of T2DM patients, was found in this study.
circulation_biomarker_diagnosis_ns	35157730	hsa-mir-192	Hepatitis B, Chronic	The serum miR5p level was useful as a biomarker for the therapeutic efficacy of Peg-IFN in CHB treatment.
circulation_biomarker_diagnosis_up	35157721	hsa-mir-21	Carcinoma, Hepatocellular	Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor.
circulation_biomarker_diagnosis_up	35157721	hsa-mir-29c	Carcinoma, Hepatocellular	Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor.
circulation_biomarker_diagnosis_up	35157721	hsa-mir-155	Carcinoma, Hepatocellular	Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor.
genetics_knock down_promote	35157222	hsa-mir-155	Acute Lung Injury	Whether miR-155/SOCS1 axis could regulate the acute lung injury caused by C. Knockdown of miR-155 improved the acute lung injury, suppressed inflammatory factors and fungus loading through SOCS1.
other	35157005	hsa-mir-182	Cholangiocarcinoma	5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases.
other	35157005	hsa-mir-1	Cholangiocarcinoma	5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases.
other	35157005	hsa-mir-92a	Cholangiocarcinoma	5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases.
lncRNA target	35156900	hsa-mir-197	Adenocarcinoma of Lung	In summary, this research demonstrated that circular RNA circMMD_007 could promote the oncogenic effects in the progression of LC through miR3p/PTPN9 axis.
circulation_biomarker_diagnosis_down	35156897	hsa-mir-885	Asthma	3p expression in acute asthma patients' plasma was significantly downregulated.
circulation_biomarker_diagnosis_up	35156729	hsa-mir-182	Coronary Artery Disease	5p, and TLN1 in the serum samples of CAD and non-CAD individuals was assessed via a real-time quantitative polymerase chain reaction.
circulation_biomarker_diagnosis_up	35156729	hsa-mir-9	Coronary Artery Disease	5p, and TLN1 in the serum samples of CAD and non-CAD individuals was assessed via a real-time quantitative polymerase chain reaction.
other	35156543	hsa-mir-484	Colorectal Neoplasms	Also, DLK1 silencing reversed the effects of downregulated miR-484 on migration, invasion, sphere formation, and CSC molecules expressions in CRC cells.
circulation_biomarker_diagnosis_ns	35156517	hsa-mir-23a	Sepsis, Intensive Care Unit-Acquired	Rs12196996 GG and rs2232365 AA were also correlated with increased level of miR-23a, IL-10 and decreased level of TNF, IL-2, IFN, IL-6 and IL-1beta in the peripheral blood cell samples of patients with ICU-acquired sepsis.
lncRNA target	35156516	hsa-mir-664b	Colonic Neoplasms	The study indicated that miR-664b-3p plays a significant role in colon cancer and could regulate the progression of colon cancer tumor growth by suppressing the expression of BUB3 protein.
lncRNA target	35156514	hsa-let-7a	Liver Neoplasms	Therefore, LncRNA RSU1P2 promotes tumorigenesis and cancer stem cell-like properties in liver cancer through let-7a/Tex10 pathway.
genetics_overexpression_promote	35156513	hsa-mir-656	Melanoma	Rescue assays indicated that miR-656 overexpression inhibited the aforementioned cellular activities in melanoma cells, which were reversed by SERBP1 overexpression.
exosome	35156510	hsa-mir-154	Esophageal Squamous Cell Carcinoma	In conclusion, our study identified that exosomes-derived miR
lncRNA target	35156509	hsa-mir-138	Esophageal Squamous Cell Carcinoma	Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR
lncRNA target	35156509	hsa-mir-1291	Esophageal Squamous Cell Carcinoma	Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR
lncRNA target	35156509	hsa-mir-6852	Esophageal Squamous Cell Carcinoma	Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR
lncRNA target	35156508	hsa-mir-339	Glioma	3p/IP6K2 regulatory axis might be a potential therapeutic target for glioma.
genetics_knock down_suppress	35156507	hsa-mir-18b	Squamous Cell Carcinoma of Head and Neck	However, inhibiting miR-18b-5p or overexpression of Y-box protein 2 (YBX2) can reverse the effect of circ-CLK1 knockdown on OSCC cells. Therefore, circ-CLK1 inhibited the apoptosis of OSCC cells through the miR-18b-5p/YBX2 axis, and these findings suggest that circ-CLK1 could be a potential therapeutic target for OSCC patients.
exosome	35156506	hsa-mir-15b	Laryngeal Neoplasms	Overall, tumor-derived exosomal miR-15b-5p augments LCa through targeting down-regulation of TXNIP.
genetics_overexpression_promote	35156481	hsa-mir-497	Uterine Cervical Neoplasms	5p was at low level in human CC cell lines, while FASN was overexpressed and demonstrated as a target of miR
other	35156321	hsa-mir-145	Melanoma	Upregulation of the miR-143/-145 cluster under BRAFi/MAPKi therapy was observed in melanoma cells in vitro and in vivo and was associated with an invasive/undifferentiated profile.
genetics_knock down_promote	35156240	hsa-mir-650	Carcinoma, Hepatocellular	Moreover, miR-650 down-regulation or TIMP3 up-regulation reversed the effects of lncRNA NBR2 knockdown that caused an enhancement of cell viability, migration and invasiveness in remifentanil-treated HCC cells.
exosome	35155688	hsa-mir-22	Alopecia	CONCLUSION: ADSC-Exos therapy positively affected the promotion of hair regrowth by regulating miR-22, the Wnt/beta-catenin signaling pathway, and the TNF-alpha signaling pathway, implying that ADSC-Exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia.
lncRNA target	35155576	hsa-mir-135b	Diabetic Cardiomyopathies	Ranolazine treatment of diabetic cardiac fibrosis inhibited pyroptosis and collagen deposition by upregulating miR-135b.
virus_miRNA	35155300	hsv1-mir-H9	Prostatic Neoplasms	Expression of hsv1-miR-H18 and hsv2-miR-H9 was significantly higher in primary tumors from PCa patients than in BPH controls (P < 0.0001).
virus_miRNA	35155300	hsv1-mir-H18	Prostatic Neoplasms	Expression of hsv1-miR-H18 and hsv2-miR-H9 was significantly higher in primary tumors from PCa patients than in BPH controls (P < 0.0001).
other	35155200	hsa-mir-145	gastric adenocarcinoma	After performing bioinformatics analysis, the CCDC144NL-AS1/hsa-miR5p/SERPINE1 ceRNA network associated to STAD prognosis of STAD was obtained.
target gene	35154537	hsa-mir-524	Thyroid Neoplasms	Ginsenoside Rh2 inhibits thyroid cancer cell migration and proliferation via activation of miR-524-5p.
other	35154526	hsa-mir-499b	Carcinoma, Hepatocellular	There was a significant association between rs10061133 miR-499b and the risk of HCC.
circRNA target	35154515	hsa-mir-326	Urinary Bladder Neoplasms	CONCLUSION: hsa_circ_0139402 plays a oncogene in BC and that can effectively promote cell proliferation, migration, invasion, and EMT by targeting Paired Box Protein Pax-8 (PAX8) via hsa-miR-326 and provides a potential therapeutic target for BC patients.
target gene	35154460	hsa-mir-506	Ovarian Neoplasms	MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2.
genetics_overexpression_promote	35154459	hsa-mir-17	Colorectal Neoplasms	Overexpression of miR
target gene	35154447	hsa-mir-181	Lymphoma, Large B-Cell, Diffuse	LncRNA SNHG5 can Regulate the Proliferation and Migration of Diffuse Large B Cell Lymphoma Progression via Targeting miR-181-5p/XIAP.
lncRNA target	35154444	hsa-mir-363	Colorectal Neoplasms	3p/GALNT7 axis exerts on key roles in cell proliferation and presents an emerging target for CRC therapy and prognostic biomarker.
transcription factor target	35154347	hsa-mir-24	Myocardial Ischemia	In addition, the study explored the possible mechanism through which SYD could reduce myocardial ischemia apoptosis and regulate the expression of the miR-24/Bim pathway.
circulation_biomarker_diagnosis_up	35154347	hsa-mir-24	Chorea	These cardiomyocytes were transfected with an miR-24 mimic and an miR-24 inhibitor and then cocultured with SYD-containing serum.
other	35154259	hsa-mir-1299	Ovarian Neoplasms	Our findings interpret the underlying mechanisms of the CDR1as/miR-1299/PPP1R12B axis and shed light on the clinical applications for CDDP-chemoresistant OC.
target gene	35154253	hsa-mir-378a	Osteosarcoma	Hypoxia-Induced miR-378a-3p Inhibits Osteosarcoma Invasion and Epithelial-to-Mesenchymal Transition via BYSL Regulation.
other	35154084	hsa-mir-133	Lichen Sclerosus et Atrophicus	In this study, we showed that the expression of miR-133 was significantly up-regulated in the mud crab Scylla paramamosain after infection by white spot syndrome virus (WSSV) or Vibrio parahaemolyticus.
genetics_knock down_promote	35154084	hsa-mir-133	Werner Syndrome	miR-133 Knockdown enhanced the apoptosis or phagocytosis of crab hemocytes, and increased the mortality of mud crabs after WSSV or V.
other	35153496	hsa-mir-132	Diabetic Retinopathy	RESULTS: We observed that levels of miR-126 and miR-132 were decreased in NPDR subjects in comparison to DNR.
circulation_biomarker_diagnosis_ns	35153496	hsa-mir-126	Diabetic Retinopathy	CONCLUSION: Circulating miRs 126 and 132 in plasma or vitreous may serve as biomarkers for early diabetic retinopathy risk prediction, provided validated in a larger cohort and other forms of retinal vasculopathy or retinopathy in the future.
circulation_biomarker_diagnosis_up	35152853	hsa-mir-148b	Osteosarcoma	miR-148b-3p mimic or inhibitor, pcDH-SOS1 plasmid or si-SOS1 and agomir-miR-148b-3p were constructed for cell transfection.
lncRNA target	35152842	hsa-mir-486	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Altogether, silencing of PVT1 inhibited ALL cell growth and induced cell apoptosis through sponging miR
circRNA target	35152839	hsa-mir-449a	Uterine Cervical Neoplasms	The circCDK6 participated in tumorigenesis and cancer progression and might serve as a tumor suppressive factor in cervical cell progression via Epithelial-MesenchymalTransition (EMT) process by regulating miR-449a.
lncRNA target	35152838	hsa-mir-641	Breast Neoplasms	In conclusion, LINC00665 could promote the survival and metastasis of breast cancer cells through sponging miR-641 and targeting SRCAP.
other	35152718	hsa-mir-190	Aortic Valve Insufficiency	Results: miR-136, miR-208 and miR-190 were upregulated in the AR group.
other	35152718	hsa-mir-136	Aortic Valve Insufficiency	Results: miR-136, miR-208 and miR-190 were upregulated in the AR group.
other	35152718	hsa-mir-208	Aortic Valve Insufficiency	Results: miR-136, miR-208 and miR-190 were upregulated in the AR group.
lncRNA target	35152537	hsa-mir-495	Cardiotoxicity	3p as an endogenous protectant against Dox-induced cardiotoxicity through activating AKT pathway in vivo and in vitro.
genetics_overexpression_promote	35152529	hsa-mir-203a	Squamous Cell Carcinoma of Head and Neck	Transwell assays showed that invasion and migration of OSCC cells were enhanced by HOXD-AS1 and Annexin A4 overexpression but were reduced by miR-203a-5p overexpression.
genetics_overexpression_promote	35152215	hsa-mir-769	Osteosarcoma	5p upregulation accelerated the viability and mobility of osteosarcoma cells, which can be blocked by RARRES1 overexpression.
lncRNA target	35151688	hsa-mir-673	Tuberous Sclerosis	5p targets the regulator of mechanistic target of the rapamycin (mTOR) complex 1 (mTORC1) tuberous sclerosis complex 2 in SCs, leading to the activation of downstream signaling pathways including mTORC1 and sterol-regulatory element binding protein 2.
lncRNA target	35151575	hsa-mir-339	Polycystic Ovary Syndrome	5p inhibitor group had higher protein expressions of PI3K, AKT and SIRT1 but lower expression of PGC-1alpha in PCOS patients (P < 0.001, P=0.030, P=0.047, P=0.003).
other	35151325	hsa-mir-338	Osteosarcoma	Further, in association with immune cell infiltration, hsa-circ-0010220, hsa-miR-326, hsa-miR3p, and FAM98A were identified as potential novel biomarkers for OS diagnosis.
other	35151325	hsa-mir-326	Osteosarcoma	Further, in association with immune cell infiltration, hsa-circ-0010220, hsa-miR-326, hsa-miR3p, and FAM98A were identified as potential novel biomarkers for OS diagnosis.
other	35151110	hsa-mir-125b	Celiac Disease	5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity.
other	35151110	hsa-mir-192	Celiac Disease	5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity.
other	35151110	hsa-mir-215	Celiac Disease	5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity.
other	35150890	hsa-mir-485	Tuberculosis, Pulmonary	"5p, SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid may collectively constitute the ""integrative pattern"" of multiple biomarkers, which may provide an accurate diagnosis of TB."
transcription factor target	35150797	hsa-mir-9	Genital Diseases, Male	In summary, the present study highlights the role of the SC-Exo/miR3p/StAR signaling pathway in PFOS-induced suppression of testosterone biosynthesis, advancing our understanding of molecular mechanisms for PFOS-induced male reproductive disorders.
genetics_overexpression_promote	35150479	hsa-mir-212	Alzheimer Disease	3p overexpression was linked to improved learning and memory capacities of AD rats and reduced neuronal pyroptosis linked to neuroinflammation attenuation.
genetics_overexpression_promote	35150405	hsa-mir-139	Carcinoma, Non-Small-Cell Lung	3p on the LUSC cell phenotypes could be blocked by overexpressing CHEK1.
circulation_biomarker_diagnosis_up	35150402	hsa-mir-181b	Carcinoma, Non-Small-Cell Lung	RESULTS: We demonstrated that miR-181b was up-regulated in exosomes derived from NSCLC patients' serum and NSCLC cells.
epigenetics	35149775	hsa-mir-152	Heart Failure	3p by promoting the methylation of miR
lncRNA target	35149732	hsa-mir-520a	Lung Neoplasms	Targeting miR-520a-5p could be an approach to restoring FZD9 expression and improving response to iloprost lung cancer chemoprevention.
lncRNA target	35149697	hsa-mir-200a	Carcinoma, Ovarian Epithelial	Therefore, the SNHG10/miR-200a-3p/BIN1 axis may act as a potential predictive biomarker and therapeutic target for treating EOC.
lncRNA target	35149188	hsa-mir-24	Cardiomyopathies	3p contributes to the reduction of cardiac fibrosis and that it might be targeted therapeutically to alleviate cardiac fibrosis.
genetics_overexpression_promote	35148687	hsa-mir-18a	Osteoarthritis	MiR-18a-3p overexpression suppressed OA progression in vivo.
genetics_knock down_suppress	35148669	hsa-mir-338	Sepsis	In sum, our results elaborated that circHIPK3 knockdown attenuated LPS-triggered HK2 cell injury by regulating FOXA1 expression via interacting with miR-338, suggesting that circHIPK3 might be a potential biomarker and therapeutic target for sepsis-induced AKI patients.
genetics_knock down_suppress	35148669	hsa-mir-338	Acute Kidney Injury	In sum, our results elaborated that circHIPK3 knockdown attenuated LPS-triggered HK2 cell injury by regulating FOXA1 expression via interacting with miR-338, suggesting that circHIPK3 might be a potential biomarker and therapeutic target for sepsis-induced AKI patients.
transcription factor target	35148667	hsa-mir-135a	Heart Diseases	Moreover, over-expression of miR-135a-5p resulted in inhibition of inflammatory infiltration and almost eliminated cardiac fibrosis, as evidenced by decreased Collagen (COL)-I, COL-III, a-smooth muscle actin, NLRP3, tumor necrosis factor-alpha, and interleukin-6. Collectively, our findings indicated that miR-135a-5p over-expression inhibited TXNIP expression to block the binding of TXNIP and NLRP3, thereby alleviating hypertensive cardiac inflammation and fibrosis.
transcription factor target	35148667	hsa-mir-135a	Diabetic Nephropathies	Moreover, over-expression of miR-135a-5p resulted in inhibition of inflammatory infiltration and almost eliminated cardiac fibrosis, as evidenced by decreased Collagen (COL)-I, COL-III, a-smooth muscle actin, NLRP3, tumor necrosis factor-alpha, and interleukin-6. Collectively, our findings indicated that miR-135a-5p over-expression inhibited TXNIP expression to block the binding of TXNIP and NLRP3, thereby alleviating hypertensive cardiac inflammation and fibrosis.
lncRNA target	35148461	hsa-mir-99a	Urinary Bladder Neoplasms	In summary, tumor-suppressive miR-99a-5p induced cellular senescence in gemcitabine-resistant bladder cancer cells by targeting SMARCD1.
other	35147479	hsa-mir-216a	Diabetic Nephropathies	RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased.
other	35147479	hsa-mir-192	Diabetic Nephropathies	RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased.
other	35147479	hsa-mir-217	Diabetic Nephropathies	RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased.
other	35147479	hsa-mir-224	Diabetic Nephropathies	RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased.
genetics_overexpression_promote	35147250	hsa-mir-146a	Osteoarthritis	Overexpression of miR-146a diminished the protective effects of melatonin by inhibiting NRF2 expression and aggravating OA-induced cartilage degradation.
transcription factor target	35146917	hsa-mir-129-2	Carcinoma, Non-Small-Cell Lung	2 can serve as a potential diagnostic and therapeutic target in NSCLC.
circulation_biomarker_diagnosis_up	35146790	hsa-mir-210	Varicocele	Seminal plasma MIR210HG expression is upregulated in VC patients, is associated with the severity of VC and may function as an independent predictor of VC-related dyszoospermia.
circulation_biomarker_diagnosis_up	35146790	hsa-mir-210	Azoospermia	Seminal plasma MIR210HG expression is upregulated in VC patients, is associated with the severity of VC and may function as an independent predictor of VC-related dyszoospermia.
other	35145966	hsa-mir-127	Breast Neoplasms	3p, RPL36 and RPL27A mRNAs.
other	35145966	hsa-mir-2114	Breast Neoplasms	3p, RPL36 and RPL27A mRNAs.
lncRNA target	35145900	hsa-mir-18a	Carcinoma, Hepatocellular	In Huh-7 (R) and HCCLM3 (R) cells, CASC2 affected cell proliferation through the miR-18a/RIPK1 axis and the NF-kappaB signaling. In conclusion, CASC2 affects cell growth mainly via the miR-24/caspase-8 and miR-221/caspase-3 axes in TRAIL-sensitive HCC cells; while in TRAIL-resistant HCC cells, CASC2 affects cell growth mainly via miR-18a/RIPK1 axis and the NF-kappaB signaling.
other	35145896	hsa-mir-126	Diabetes Mellitus	Also, vitamin D3+ATRA can be considered a new therapeutic agent that can elevate miR-126 expression and prevent diabetes-related cardiovascular complications.
other	35145563	hsa-mir-4	Uterine Cervical Neoplasms	5p to regulate HMGB1.
other	35145542	hsa-mir-186	Carcinoma, Renal Cell	Next, we successfully constructed a ceRNA network of two mRNA (NR3C2 and VAV3), miRNA (hsa-miR5p), and lncRNA (NNT-AS1) for ccRCC based on numerous online bioinformatics tools and Cytoscape.
other	35145534	hsa-mir-167	Li-Fraumeni Syndrome	A new network of ceRNAs correlated with LF was constructed, and it consisted of one mRNA (PsTPS1), one lncRNA (TCLR, LTCONS_00034157), and one miRNA (miR167h).
other	35145514	hsa-mir-194	Graft vs Host Disease	In the present study, we further investigated the role of the expression profile of membrane proteins and their microRNA (miRNA) cargo (miRNA100, miRNA155, and miRNA194) in predicting the onset of aGvHD in haploidentical transplant recipients with PT-Cy. This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975).
circulation_biomarker_prognosis_ns	35145164	hsa-mir-1290	Colorectal Neoplasms	miR-1246 and miR-1290 levels were significantly higher in the plasma of patients with CRC than in the plasma of healthy controls (P < 0.05). The tissue expression of miR-200c-3p and plasma levels of miR-1290 measured by ddPCR indicate their potential as prognostic biomarkers for CRC.
target gene	35144475	hsa-mir-200c	Wilms Tumor	microRNA-200c-3p suppresses proliferation and invasion of nephroblastoma cells by targeting EP300 and inactivating the AKT/FOXO1/p27 pathway.
other	35144146	hsa-mir-721	Myocarditis	Herein, we propose a generic and non-enzymatic electrochemical strategy integrated molecular beacon-like catalyzed hairpin assembly (mCHA) circuit with MOF@Au@G-triplex/hemin nanozyme for ultrasensitive detection of miR-721 (a novel diagnostic biomarker of acute myocarditis). The proposed biosensor has been successfully used in miR-721 detection in real biological samples, which provided a promising potential method for acute myocarditis early diagnosis.
lncRNA target	35144130	hsa-mir-223	Inflammation	Then, the change of inflammatory injury and activation of NLRP3 inflammasomes in B(a)P-induced A549 cells were detected after inhibiting of GSDMD or miR-223 using siRNA-GSDMD (siGSDMD) or miR-223 inhibitor, respectively.
transcription factor target	35144130	hsa-mir-223	Gerstmann-Straussler-Scheinker Disease	In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells.
transcription factor target	35144130	hsa-mir-223	Pneumonia	However, whether GSDMD regulate NLRP3 inflammasome through miR-223 in B(a)P induced lung inflammatory injury remain unknown.
genetics_overexpression_promote	35143426	hsa-mir-20a	Carcinoma, Hepatocellular	RUNX3 was not only reduced in HCC specimens but also drastically reduced in HCC cells overexpressing miR-20a-5p.
genetics_overexpression_promote	35143103	hsa-mir-515	Colorectal Neoplasms	5p overexpression on the biological behaviors of CRC cells above.
lncRNA target	35143052	hsa-mir-513c	Squamous Cell Carcinoma of Head and Neck	These studies verified that CDK5 regulates the occurrence and development of TSCC cells through the microRNA 513c-5p/cell division cycle 25B pathway. In addition, the authors observed that CDK5 regulated the growth of TSCC through the microRNA 513c-5p/cell division cycle C25B pathway.
circRNA target	35142978	hsa-mir-520h	Diabetic Nephropathies	CONCLUSION: GEC-circTAOK1-Exo could boost proliferation, fibrosis, and EMT of GMC through targeting the miR-520h/SMAD3 axis, providing new insights into the pathogenesis of DN.
genetics_knock down_promote	35142935	hsa-mir-30	Squamous Cell Carcinoma of Head and Neck	3p partly reversed circ_0120175 knockdown-induced effects in LSCC cells.
lncRNA target	35142692	hsa-mir-101a	Spinal Cord Ischemia	These findings suggest that the miR-101a-3p mimic improved spinal ischemia/reperfusion injury-induced nerve cell apoptosis and inflammation by inhibiting MYCN and the p53 signaling pathway. Therefore, miR-101a-3p mimic therapy may be a potential treatment option for spinal ischemia/reperfusion injury.
genetics_knock down_promote	35142595	hsa-mir-136	Pancreatic Carcinoma	Overall, DSCAM-AS1 knockdown inhibits pancreatic cancer progression by modulating the miR
circulation_biomarker_diagnosis_up	35142592	hsa-mir-29c	Polycystic Ovary Syndrome	PCOS rats were injected with plasmids vectors interfering with miR-29 c-3p or Foxo3 expression, respectively.
lncRNA target	35142579	hsa-mir-128-2	Pancreatitis	2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-kappaB65, and p-IkappaB-alpha expression levels, suppressed NF-kappaB65 and the TLR4 expression levels, reduced MPO activity, reduced TNF-alpha, IL-1beta, IL-6, and ICAM-1 levels in BALF, and alleviated SAP-induced ALI.
lncRNA target	35142579	hsa-mir-128-2	Acute Lung Injury	2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-kappaB65, and p-IkappaB-alpha expression levels, suppressed NF-kappaB65 and the TLR4 expression levels, reduced MPO activity, reduced TNF-alpha, IL-1beta, IL-6, and ICAM-1 levels in BALF, and alleviated SAP-induced ALI.
genetics_knock down_suppress	35142578	hsa-mir-24	Pneumonia	Circ_0026579 knockdown alleviated LPS-induced WI-38 cells inflammation by miR3p/IGF2 axis, suggesting that circ_0026579 might contribute to infantile pneumonia progression.
circulation_biomarker_prognosis_ns	35141939	hsa-mir-21	Acute Lung Injury	3p in plasma are correlated with the severity and prognosis of ALI patients, and their combination has a high value for the prognostic assessment of ALI patients.
lncRNA target	35141790	hsa-mir-206	Non-alcoholic Fatty Liver Disease	RMRP inhibition prevented NAFLD progression in rats via targeting the miR-206/PTPN1 axis.
other	35141302	hsa-mir-490	Atrial Fibrillation	3p/LRRC2 network based on ceRNA theory in AF in the bioinformatic analyses of public datasets.
circRNA target	35141166	hsa-mir-31	Enterovirus B, Human	In conclusion, this study found that circSIAE can target TAOK2 through sponge adsorption of miR
lncRNA target	35141164	hsa-mir-497	Pancreatic Carcinoma	Rescue experiments demonstrated that the effects of SNHG1 downregulation on PC cells were attenuated when simultaneously inhibiting the levels of miR-497. CONCLUSIONS: SNHG1 upregulates FGFR1 expression by sponging miR-497, which promotes the progression of PC.
other	35140604	hsa-mir-34a	Osteoarthritis	Furthermore, changes of miR-146a-5p and miR-34a-5p in the cellular models were recovered by DHJSD administration, which synergistically contributed to OA therapy.
other	35140604	hsa-mir-146a	Osteoarthritis	Furthermore, changes of miR-146a-5p and miR-34a-5p in the cellular models were recovered by DHJSD administration, which synergistically contributed to OA therapy.
other	35140551	hsa-mir-615	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
other	35140551	hsa-mir-92b	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
other	35140551	hsa-mir-3180	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
other	35140551	hsa-mir-4433b	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
other	35140551	hsa-mir-490	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
other	35140551	hsa-mir-1908	Sarcoma, Kaposi	5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique.
exosome	35140333	hsa-mir-940	Carcinoma, Hepatocellular	Apart from the downregulation of HIF-1a/VEGF expression in HCC cells, PBLD also blocks VEGF receptor 2 (VEGFR2) on endothelial cells via HCC-derived exosomal miR-940.
other	35139769	hsa-mir-145	Cardiomegaly	Collectively, our findings have indicated that the H19/miR3p/SMAD4 axis should be a negative regulator involved in CH progression.
circulation_biomarker_diagnosis_up	35139491	hsa-mir-601	Glioblastoma	The effects of miR-601 dysregulation on GBM cell proliferation by mean transit time (brain tissue blood flow) (MTT) assays, colony formation, anchorage-independent growth assay, bromodeoxyuridine (BrdU) labeling and immunofluorescence assay.
transcription factor target	35138580	hsa-mir-103	Osteoarthritis	In this study, the levels of VMA21, pre-miR-103, and mature miR-103 in synovial fluid samples from OA patients (n = 56) and controls (n = 56) were analyzed using RT-qPCR.
genetics_overexpression_promote	35138469	hsa-mir-586	Stomach Neoplasms	Exosomal circ_0001190 overexpression inhibited the development of GC by miR-586/SOSTDC1 axis, which proposed a potential targeted therapy for GC cure.
other	35138425	hsa-mir-137	Neurotic Disorders	Duration of methamphetamine use or abstinence, cigarette smoking status, depressive disorder, or antidepressant treatment did not interact with the methamphetamine abstinence-induced reduction of cEV miR-137.
other	35137927	hsa-mir-1262	Sepsis	These findings highlighted the importance of the hsamiR1262/SLC2A1 signaling pathway in septic myocardial injury and provided novel insights into therapeutic strategies for septic myocardial depression.
exosome	35137672	hsa-mir-374a	Fibrosis, Renal	In conclusion, exosomal miR-374a-5p inhibited the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis.
other	35137671	hsa-mir-17	Parkinson Disease	Here, we addressed the role of lncRNA miR92a-1 cluster host gene (MIR17HG) in Parkinson's disease (PD).
lncRNA target	35137671	hsa-mir-153	Parkinson Disease	Overall, MIR17HG, by targeting miR
lncRNA target	35137670	hsa-mir-139	Stomach Neoplasms	3p inhibited proliferative, migratory, and invasive abilities of GC cells, while caused cell-cycle arrest.
circRNA target	35137664	hsa-mir-15b	Wounds and Injuries	circCHFR expression was upregulated in patients with atherosclerosis and oxidized low-density lipoprotein (ox-LDL)-exposed HUVECs, whereas miR-15b-5p expression was downregulated. In conclusion, circCHFR promotes atherosclerosis progression via the miR-15b-5p/GADD45G axis and may be an important target for atherosclerosis treatment.
lncRNA target	35137654	hsa-mir-21	Neuroma, Acoustic	BRCAT54 suppressed primary VS cell proliferation and inhibited the role of miR-21 in promoting cell proliferation.
lncRNA target	35137650	hsa-mir-10a	Carcinoma, Non-Small-Cell Lung	In NSCLC cells, LINRIS silencing showed no role in miR-10a precursor accumulation but downregulated mature miR10a level. Overall, LINRIS silencing may inhibit NSCLC cell proliferation by suppressing miR-10a maturation.Abbreviations: Non-small cell lung cancer (NSCLC); Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR); LncRNA long intergenic noncoding RNA for IGF2BP2 stability (LINRIS).
lncRNA target	35137600	hsa-mir-139	Carcinoma, Hepatocellular	3p regulated cell behaviors in HCC through targeting UCK2.
transcription factor target	35137483	hsa-mir-520c	Pre-Eclampsia	RESULTS: Low expression of MT1, MT2, and miR-520c-3p and high expression of SETD7 and HtrA1 were observed in the placental tissues of PE patients and H/R-treated HTR8/Svneo cells. CONCLUSION: Melatonin may inhibit HtrA1 transcription through the miR-520c-3p/SETD7 axis to promote trophoblast invasion and migration and reduce trophoblast pyroptosis in PE.
exosome	35137328	hsa-mir-200a	Esophageal Squamous Cell Carcinoma	Our results suggest that exosome-shuttled miR-200a might be useful as a biomarker for prognosis in patients with ESCC.
lncRNA target	35137264	hsa-mir-23a	Subarachnoid Hemorrhage	Overall, suppression of miR-23a-3p improves cognitive function after SAH by targeting VCAN.
other	35137158	hsa-mir-26	Alcohol Withdrawal Delirium	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-221	Muscular Dystrophy, Duchenne	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-23	Muscular Dystrophy, Duchenne	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-17	Alcohol Withdrawal Delirium	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-19	Alcohol Withdrawal Delirium	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-17	Muscular Dystrophy, Duchenne	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-23	Alcohol Withdrawal Delirium	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-26	Muscular Dystrophy, Duchenne	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-19	Muscular Dystrophy, Duchenne	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
other	35137158	hsa-mir-221	Alcohol Withdrawal Delirium	We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs.
lncRNA target	35136398	hsa-mir-21	Myocardial Reperfusion Injury	5p/PDCD4 signaling pathway that mediates the apoptosis of cardiomyocytes and successfully alleviates IRI in myocardial cells by co-culture with miR
genetics_GWAS	35136075	hsa-mir-125a	Intracranial Aneurysm	Therefore, an increased level of miR-125a can lead to the increased risk of IA re-bleeding. Since miR-125a level is higher in CC-genotyped patients, it can be concluded that the presence of T allele in the rs12976445 polymorphism is associated with a lower risk of IA re-bleeding, and miR-125a may be used as a novel diagnostic and therapeutic target for IA rupture.
exosome	35136055	hsa-mir-494	Lung Neoplasms	3p inhibitor blocked sEV-mediated effects by targeting tyrosine-protein phosphatase nonreceptor type 12 (PTPN12), a tumor suppressor.
lncRNA target	35136049	hsa-mir-578	Intervertebral Disc Degeneration	These data suggested that circ_0134111 could promote the progression of IDD through enhancing aberrant NP cell growth, inflammation, and ECM degradation partly via regulating miR-578.
lncRNA target	35136034	hsa-mir-10b	Glioblastoma	We further identify a SOX2:miR-10b-5p:TET2 axis that represses TET2 expression, represses 5hmC, increases 5mC levels, and induces GBM cell stemness and tumor-propagating potential. In vivo delivery of a miR-10b-5p inhibitor that normalizes TET2 expression and 5hmC levels inhibits tumor growth and prolongs survival of animals bearing pre-established orthotopic GBM xenografts.
lncRNA target	35136029	hsa-mir-150	Myelodysplastic Syndromes	5p/MYB positive feedback loop promoted the proliferation of MDS cells and is expected to be a potential biomarker and therapeutic target in MDS.
exosome	35136028	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	5p loaded exosomes from NSCLC cells in Rab27A and Rab27B dependent manners.
circulation_biomarker_diagnosis_ns	35135571	hsa-mir-21	Ataxia Neuropathy Spectrum	CONCLUSIONS: Furthermore, the proposed assay was applied for detecting microRNA-21 in dilute human serum samples with satisfactory recovery and also in MCF-7 cell lines in the range 3000 to 45,000 (cell mL(-1)) with a detection limit (3 cells in 10 muL), demonstrating the potential of the assay for clinic diagnosis of microRNA-associated disease.
transcription factor target	35135443	hsa-mir-99a	Spinal Cord Injuries	To sum up, miR-99a suppresses NOX4 expression to relieve the LPS-induced inflammation, apoptosis and the progression of oxidative stress in SCI.
transcription factor target	35135443	hsa-mir-99a	Inflammation	To sum up, miR-99a suppresses NOX4 expression to relieve the LPS-induced inflammation, apoptosis and the progression of oxidative stress in SCI.
genetics_knock down_promote	35135416	hsa-mir-514a	Thyroid Neoplasms	Besides, circ-ZNF609 sponged miR-514a-5p and miR-514a-5p knockdown reversed the suppressed impacts of circ-ZNF609 knockdown on TC cell malignant biological behaviors.
other	35134991	hsa-mir-1305	Nerve Degeneration	Of the 39 miRNAs, 5 miRNAs, 3 downregulated (miR-20a, miR-30b, and miR-30d) and 3 upregulated (miR-1243 and miR-1305), correlated well with morphological changes induced by multiple neurotoxicants and were notable based on their relationship to various neurodegenerative conditions and/or key pathways, such as TGF-beta signaling.
other	35134991	hsa-mir-20a	Nerve Degeneration	Of the 39 miRNAs, 5 miRNAs, 3 downregulated (miR-20a, miR-30b, and miR-30d) and 3 upregulated (miR-1243 and miR-1305), correlated well with morphological changes induced by multiple neurotoxicants and were notable based on their relationship to various neurodegenerative conditions and/or key pathways, such as TGF-beta signaling.
lncRNA target	35134495	hsa-mir-198	Carcinoma, Non-Small-Cell Lung	Circ_0004015 conferred DDP resistance and promoted NSCLC progression by miR-198/KLF8 pathway, proving a potential target for studying DDP-mediated treatment of NSCLC.
lncRNA target	35133561	hsa-mir-122	Cardiomyopathies	Collectively, these data indicated that miRNA5p is an essential regulator of autophagy and apoptosis in rat CFs via the apelin/AMPK/mTOR signaling pathway, which may be potentially used as a therapeutic target in myocardial fibrosis and related diseases.
transcription factor target	35133054	hsa-mir-16	Lymphoma, T-Cell, Cutaneous	We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL).
transcription factor target	35133054	hsa-mir-150	Lymphoma, T-Cell, Cutaneous	We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL).
genetics_knock down_promote	35133054	hsa-mir-26	Lymphoma, T-Cell, Cutaneous	In vitro analysis of IL22 and IL22RA knockdown and miR-26 transduction demonstrated inhibited CTCL cell migration.
transcription factor target	35133054	hsa-mir-29	Lymphoma, T-Cell, Cutaneous	We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL).
genetics_knock down_promote	35133000	hsa-mir-377	Adenocarcinoma of Lung	3p was able to promote gefitinib resistance in spite of hsa_circ_0000567 knockdown.
other	35132928	hsa-mir-1182	Carcinoma, Non-Small-Cell Lung	Together, our findings reveal a novel mechanism by which the circCAMSAP1/miR-1182/BIRC5 axis promotes NSCLC progression.
lncRNA target	35132819	hsa-mir-579	Carcinoma, Hepatocellular	3p was identified as a novel tumor suppressor regulating phosphoinositide 3-kinase-AKT signaling at the early stages of HCC development.
transcription factor target	35132534	hsa-mir-485	Sleep Apnea, Obstructive	5p alleviates OSAS with hypertension by inhibiting the PI3K/Akt pathway via downregulating HIF3A expression through the PI3K/AKT pathway.
genetics_overexpression_promote	35132352	hsa-mir-21	Peripheral Nerve Injuries	Furthermore, the effects of Schwann cells- (SC-) derived exosomes on the overexpression of miR-21 for the treatment of PNI were investigated.
other	35132320	hsa-mir-580	Ovarian Neoplasms	Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling.
lncRNA target	35131594	hsa-mir-22	Liver Diseases	The objective of this study is to investigate the internal mechanism by which microRNA-22 (miR-22) targets family with sequence similarity 49 member B (FAM49B), thus aggravating hepatic I/R injury. Here, we found that miR-22 was upregulated while FAM49B was reduced in hepatic I/R injury.
transcription factor target	35131475	hsa-mir-146a	Condylomata Acuminata	Subsequently, we verified four up-regulated hub genes IFIT1, IFI27, OASL, SAMD9L and down-regulated mir-146a-5p in CA tissues by RT-qPCR. Our study revealed that mir-146a-5p contribute to CA progression through PI3K/AKT and p38/MAPK signaling pathway.
other	35131296	hsa-mir-34a	Neurotic Disorders	AAV-miR-34a in PL produced antidepression-behavioral effects and rescued stress-induced depressive-like behaviors. Intra-PL application of miR-34a rapidly produced antidepression-like effects and reversed stress-evoked depressive-like behaviors.
lncRNA target	35130798	hsa-mir-197	Carcinoma, Endometrioid	Collectively, hsa_circ_0039569 may promote the development of endometrial carcinoma by serving as an endogenous sponge of miR-197, increasing HMGA1 expression and identifying a novel target for endometrial carcinoma treatment.
other	35130632	hsa-mir-1205	Triple Negative Breast Neoplasms	Utilizing qRT-PCR analysis, we discovered that miR-1205 is gradually downregulated in human triple negative breast carcinoma MDA-MB-231 and docetaxel-resistant MDA-MB-231 (MDA-MB-231/DOC) cells compared with Hs 578Bst normal human breast fibroblasts. Our findings demonstrate the role of the miR-1205/DNAJB1 axis in the docetaxel resistance of TNBC, which may offer a promising therapeutic approach to resolve docetaxel resistance in TNBC.
other	35130629	hsa-mir-493	Osteosarcoma	5p.
exosome	35130628	hsa-mir-27b	Tendon Injuries	Taken together, our findings highlight a critical role of hucMSC exosomes in reducing tendon injury via miR-27b-3p-mediated suppression of ARHGAP5, resulting in RhoA activation, and leading to increased cell proliferation and invasion of primary injured tenocytes.
lncRNA target	35130616	hsa-mir-665	Carcinoma, Hepatocellular	A rescue experiment demonstrated that silencing of eliminats the inhibitory effect of the miR-665 inhibitor on sorafenib resistance in HCC cells.
circulation_biomarker_diagnosis_ns	35130573	hsa-mir-128	Duane Retraction Syndrome	3p, and there was a negative correlation in the serum of DR patients.
genetics_overexpression_promote	35130572	hsa-mir-551b	Thyroid Cancer, Papillary	The overexpression of miR-551b exerted promoted effect on the development-related cellular processes of PTC, which was reversed by the overexpression of ERBB4.
other	35129856	hsa-mir-21	Carcinoma, Renal Cell	3p predicted reduced survival (p < 0.05).
other	35129856	hsa-mir-221	Carcinoma, Renal Cell	3p predicted reduced survival (p < 0.05).
other	35129856	hsa-mir-222	Carcinoma, Renal Cell	3p predicted reduced survival (p < 0.05).
transcription factor target	35129808	hsa-mir-182	Carcinoma, Renal Cell	5p inhibited UBE2T protein expression by targeting UBE2T mRNA and then inhibited the proliferation, migration and invasion of ccRCC cell.
other	35129780	hsa-mir-146a	Breast Neoplasms	MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC subtypes.
other	35129780	hsa-mir-155	Breast Neoplasms	MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC subtypes.
genetics_knock down_promote	35129574	hsa-mir-33a	Ovarian Neoplasms	Notably, silencing of LINC00974 suppressed cell proliferation, invasion and EMT of OC cells, whereas miR-33a knockdown partially reversed the phenotypes of LINC00974 on OC cells.
other	35129424	hsa-mir-29b-2	Diabetic Nephropathies	Finally, the hsa_circRNA_012448-hsa-miR-29b5p-GSK3beta pathway, involved in the oxidative stress response, was identified as an important pathway mediating the action of dapagliflozin against DKD.
circulation_biomarker_diagnosis_up	35129398	hsa-mir-485	Norrie disease	5p and upregulation of YAP1 were also observed in the serum of DN patients.
transcription factor target	35129398	hsa-mir-485	Inflammation	CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR
genetics_overexpression_promote	35129056	hsa-mir-149	Esophageal Squamous Cell Carcinoma	RNF2 overexpression blocked the inhibitory effect of miR-149 on ESCC cell growth.
circulation_biomarker_diagnosis_up	35129049	hsa-mir-154	Mycoses	We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01).
circulation_biomarker_diagnosis_up	35129049	hsa-let-7c	Mycoses	We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01).
circulation_biomarker_diagnosis_up	35129049	hsa-mir-215	Mycoses	We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01).
circulation_biomarker_diagnosis_up	35129049	hsa-mir-193a	Mycoses	We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01).
circulation_biomarker_diagnosis_up	35128324	hsa-mir-155	Arthritis, Rheumatoid	CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease.
circulation_biomarker_diagnosis_up	35128324	hsa-mir-146a	Arthritis, Rheumatoid	CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease.
circulation_biomarker_diagnosis_up	35128324	hsa-mir-103a	Arthritis, Rheumatoid	CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease.
genetics_overexpression_suppress	35128082	hsa-mir-29b	Osteoarthritis	microRNA-29b-3p (miR-29b-3p) is downregulated by TGF-beta1 and overexpressed in OA cartilage. Furthermore, implying that miR-29b-3p expression may be involved in reduced chondrocyte proliferation in OA.
lncRNA target	35127996	hsa-mir-194	Intervertebral Disc Degeneration	5p derived from MSCs-EVs protects TNF-alpha-intervened NP cells through restricting TRAF6, replenishing a potential target for IDD treatment.
target gene	35127818	hsa-mir-142	Urinary Bladder Neoplasms	MIR100HG Regulates CALD1 Gene Expression by Targeting miR-142-5p to Affect the Progression of Bladder Cancer Cells in vitro.
other	35127724	hsa-mir-124	Urinary Bladder Neoplasms	5p) involved in GEM-resistant BCa.
other	35127724	hsa-mir-26b	Urinary Bladder Neoplasms	5p) involved in GEM-resistant BCa.
other	35127724	hsa-mir-192	Urinary Bladder Neoplasms	5p) involved in GEM-resistant BCa.
exosome	35127706	hsa-mir-151	Spinal Cord Injuries	3p is the key molecule in microglia-derived exosomes that mediates the neuroprotective effects of SCI treatments.
target gene	35127703	hsa-mir-188	Myocardial Infarction	The circRNA_0002113/miR-188-3p/RUNX1 axis mediated alleviation of apoptosis serves as a novel strategy to treat myocardial I/R injury.
tissue_expression_up	35127575	hsa-mir-549a	Multiple Sclerosis	Due to the presence of a possible relationship between expressed miRNAs and heterogeneous appearances of the pathological processes in MS, the present study attempts to evaluate the expression of miR-129 and miR-549a in patients with MS in comparison with healthy control (HC) group. After RNA extraction and complementary DNA synthesis, the expression of miR-129 and miR-549a was evaluated in patients with MS in comparison with the HC group using a quantitative real-time polymerase chain reaction assay. RESULTS: The results showed that the expression of miR-129 and miR-549a was not significant in patients with MS in comparison with the HC group.
tissue_expression_up	35127575	hsa-mir-129	Multiple Sclerosis	Due to the presence of a possible relationship between expressed miRNAs and heterogeneous appearances of the pathological processes in MS, the present study attempts to evaluate the expression of miR-129 and miR-549a in patients with MS in comparison with healthy control (HC) group. After RNA extraction and complementary DNA synthesis, the expression of miR-129 and miR-549a was evaluated in patients with MS in comparison with the HC group using a quantitative real-time polymerase chain reaction assay. RESULTS: The results showed that the expression of miR-129 and miR-549a was not significant in patients with MS in comparison with the HC group.
other	35127565	hsa-mir-34	Lymphomatoid Granulomatosis	There was no significant difference in the expression of PMK-1 for LGG exposure in miR-34 mutants, suggesting that miR-34 may regulate PMK-1.
genetics_overexpression_promote	35127344	hsa-mir-375	Carcinoma, Hepatocellular	miR-375 was downregulated in HCC, and overexpression of miR-375 suppressed HCC cell growth.
genetics_overexpression_promote	35127343	hsa-mir-138	Glioma	RESULTS: Functional studies indicated that overexpression of miR
genetics_knock down_suppress	35127342	hsa-mir-944	Uterine Cervical Neoplasms	circ_ZFR knockdown significantly reduced IL-10 expression via sponging miR-944, increasing PTX sensitivity in PTX-resistant CC cells. CONCLUSION: circ_ZFR knockdown has a considerable role in overwhelming CC-associated PTX resistance by modifying the axis of miR-944/IL-10 axis, suggesting that developing a circRNA target-based treatment could be considered prevent CC progression.
genetics_knock down_promote	35127282	hsa-mir-148a	Urinary Bladder Neoplasms	miR-148a-3p overexpression inhibited bladder cancer cell proliferation and migration, whereas miR-148a-3p knockdown promoted bladder cancer cell proliferation and migration.
other	35127170	hsa-mir-4521	Carcinoma, Hepatocellular	These discoveries suggest that miR-4521/FAM129A might play a vital role in hepatic cancer progression and could be a candidate for its therapy.
lncRNA target	35126948	hsa-mir-206	Endometriosis	Hence, miR-206 was suggested to be a possible target for EM treatment.
transcription factor target	35126933	hsa-mir-98	Intervertebral Disc Degeneration	We concluded that miR-98 inhibited apoptosis of NP cells by inactivating the TRAIL pathway via targeting TRAIL in IVDD NP cells.
genetics_knock down_promote	35126911	hsa-mir-25	Diabetic Nephropathies	More importantly, downregulation of miR-325 and upregulation of CCNG1 can attenuate the protective effect of lncRNA MSC-AS1 knockdown on DN.
other	35126901	hsa-mir-149	Thyroid Neoplasms	Additionally, miR5p weakened the effect of CCL18 in the progression of TC.
transcription factor target	35126820	hsa-mir-154	Pulmonary Fibrosis	CONCLUSION: miR5p regulates the TGFbeta1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease.
transcription factor target	35126820	hsa-mir-154	Diabetic Nephropathies	CONCLUSION: miR5p regulates the TGFbeta1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease.
circRNA target	35126807	hsa-mir-138	Myocardial Reperfusion Injury	Overall, our findings suggest that circ_SMG6 may deteriorate myocardial I/R injury by promoting neutrophil recruitment via the miR
other	35126805	hsa-mir-19b	Heart Diseases	The QK/miR-19b/Socs6 axis plays a vital role in regulation of mitochondrial fission and cardiomyocyte apoptosis and could form the basis of future research in the development of therapies for the management of cardiac diseases.
transcription factor target	35126805	hsa-mir-19b	familial febrile seizures 1	CONCLUSIONS: Our results indicate that the inhibition of mitochondrial fission through downregulating Socs6 via the QK/miR-19b/Socs6 pathway attenuated the damage sustained by I/R.
circulation_biomarker_diagnosis_ns	35126729	hsa-mir-26a	Colorectal Neoplasms	Overall, the present study revealed serum miR-26a-5p as a potential early detection marker for CRC.
target gene	35126724	hsa-mir-224	Carcinoma, Hepatocellular	E2F1-induced microRNA-224-5p expression is associated with hepatocellular carcinoma cell migration, invasion and epithelial-mesenchymal transition via MREG.
genetics_knock down_suppress	35126706	hsa-mir-214	Maxillary Fractures	Altogether, it was revealed that TUG1 expression was decreased in patients with maxillary fractures and TUG1 knockdown repressed the biological process of osteoblasts by sponging miR-214.
lncRNA target	35126697	hsa-mir-98	Osteoporosis	Kcnq1ot1, miR5p and Tbx5 may therefore serve as promising targets for the treatment of osteoporosis.
lncRNA target	35126637	hsa-let-7b	Rotator Cuff Injuries	CONCLUSIONS: A hyperglycemic microenvironment inhibits TDSC proliferation in vitro via the let-7b-5p/CFTR pathway, and this is a potential mechanism in diabetes-induced poor tendon-to-bone healing.
genetics_overexpression_promote	35126623	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	After interference with or overexpressing miR
lncRNA target	35126622	hsa-mir-204	Breast Neoplasms	5p inhibitor on cell functions of BC.
lncRNA target	35126619	hsa-mir-143	Urinary Bladder Neoplasms	3p repressed bladder cancer cell functions and EMT through downregulating TBX3 expression.
other	35126595	hsa-mir-25	Adenocarcinoma of Lung	CONCLUSIONS: The interaction of miR-25 and PTEN in young LUAD may define a subgroup of patients, highlighting the concept of molecular testing in different age subtypes.
other	35126571	hsa-mir-10b	Melanoma	The current study is aimed to assess the values of microRNA-10b (miRNA-10b) in the discrimination of metastatic melanomas. CONCLUSION: Based on this study, metastatic melanoma was associated with elevated levels of miRNA-10b.
circulation_biomarker_prognosis_ns	35126518	hsa-mir-1246	Lung Neoplasms	Finally, exosomal miR-1246 serum may be a useful prognosis biomarker for non-small-cell lung cancer.
other	35126169	hsa-mir-34a	Fibrosis	"These findings suggest that age-related fibrosis and muscle atrophy mediated by ROS may result at least in part from an increase in miR-34a bioavailability resulting from a decline in miR-34a ""sponging"" due to ceRNA MALAT1 depletion."
other	35126169	hsa-mir-34a	Muscular Atrophy	"These findings suggest that age-related fibrosis and muscle atrophy mediated by ROS may result at least in part from an increase in miR-34a bioavailability resulting from a decline in miR-34a ""sponging"" due to ceRNA MALAT1 depletion."
lncRNA target	35126113	hsa-let-7	Non-alcoholic Fatty Liver Disease	The present data suggest that the protective effects of fenofibrate against insulin resistance and its suppressive activity against excessive hepatic lipid accumulation may be related to the alteration of the let-7/SERCA2b axis and alleviation of ER stress.
exosome	35125496	hsa-mir-133b	Diabetic Retinopathy	This study has elucidated that exosomal miR-133b-3p from BMSCs suppresses angiogenesis and oxidative stress in DR via FBN1 repression.
genetics_GWAS	35124585	hsa-mir-135a	Polycystic Ovary Syndrome	CONCLUSION: The results revealed the two SNPs as rs2289046 and rs1865434 in the IRS-2 binding region of miRNA-135a have correlations with the clinical features of PCOS in Chinese population.
genetics_overexpression_suppress	35124548	hsa-mir-4269	Colorectal Neoplasms	The nuclear overexpressed TEAD4 and downregulated miR-4269 and miR
genetics_overexpression_suppress	35124548	hsa-mir-1343	Colorectal Neoplasms	The nuclear overexpressed TEAD4 and downregulated miR-4269 and miR
lncRNA target	35124415	hsa-mir-21	Lupus Erythematosus, Systemic	In conclusion, inhibiting miR-21 in vivo improves intracellular iron homeostasis and inhibits Tfh cell overexpansion, contributing to reduced autoimmune responses and the remission of disease symptoms in murine lupus.
lncRNA target	35124344	hsa-mir-624	Ovarian Neoplasms	High expression of miR5p was recorded in ovarian drug resistant cancer cells and it also boosted the cell viabilities.
genetics_knock down_promote	35123924	hsa-mir-338	Parkinson Disease	CONCLUSION: To sum up, our data revealed that knockdown LINC00943 might alleviate PD progression through regulating the miR3p/SP1 axis.
other	35123634	hsa-mir-181a	Thrombocytopenia	CONCLUSION: The expression of miR-181a-5p is significantly decreased in ITP patients, which is closely related to the imbalance of Treg/Th17 cells.
epigenetics	35123558	hsa-mir-935	Urinary Bladder Neoplasms	RESULTS: All nine urinary methylation markers (FAM19A4, GHSR, MAL, miR-129, miR-935, PHACTR3, PRDM14, SST and ZIC1) showed significantly higher methylation levels in bladder cancer patients than in controls (p < 0.001).
epigenetics	35123558	hsa-mir-129	Urinary Bladder Neoplasms	RESULTS: All nine urinary methylation markers (FAM19A4, GHSR, MAL, miR-129, miR-935, PHACTR3, PRDM14, SST and ZIC1) showed significantly higher methylation levels in bladder cancer patients than in controls (p < 0.001).
lncRNA target	35123415	hsa-mir-152	Prostatic Neoplasms	It was noted that SNHG3 as a molecular sponge of miR3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of PCa cells via targeting SLC7A11.
exosome	35123060	hsa-mir-382	Fluoride Poisoning	Conclusions PVAT-EXOs reduce macrophage foam cell formation through miR
transcription factor target	35122989	hsa-mir-9	Pulmonary Fibrosis	Up-regulated C-MYC promoted proliferation and differentiation of pulmonary fibroblasts by inhibiting TBPL1 via activation of miR
circRNA target	35122957	hsa-mir-383	Osteoarthritis	CONCLUSION: Circ_Rapgef1 suppressed AD-mediated protective effects in OA partly by regulating miR3p/NLRP3 signaling.
circulation_biomarker_diagnosis_ns	35122770	hsa-mir-483	COVID-19	In conclusion, high levels of circulating miR-320b and miR
circulation_biomarker_diagnosis_ns	35122770	hsa-mir-20b	COVID-19	In conclusion, high levels of circulating miR-320b and miR
circulation_biomarker_prognosis_ns	35122598	hsa-mir-126	Sepsis	CONCLUSION: This study confirmed that miR-126 can regulate the differentiation of Th17/Treg, change the infiltration of inflammatory factors in peripheral blood, lung, liver and kidney of septic rats, alleviate MODS, and improve the organ function and prognosis of septic rats.
other	35122570	hsa-mir-16	Rhinitis, Allergic	induced dysfunction of NECs by lncRNA HCP5 depended on miR-16/ATXN2L in the inflammatory response of AR.
lncRNA target	35121826	hsa-mir-135	Breast Neoplasms	Collectively, our findings highlighted the role of the miR-135/ZNF217/METTL3/NANOG axis in the progression of BC, emphasizing potential therapeutic targets ZNF217 silencing and miR-135 upregulation in preventing or treating BC.
lncRNA target	35121558	hsa-mir-183	X-linked juvenile retinoschisis 1	In conclusion, we found that SNHG1 plays a critical role in the progression of RSA via miR5p/ZEB2 and Wnt/beta-catenin signaling.
circulation_biomarker_diagnosis_up	35121374	hsa-mir-448	Lupus Erythematosus, Systemic	In our study, we found high expression of miR-448 in peripheral blood mononuclear cells (PBMCs) of SLE patients, and miR-448 level was positively associated with disease severity.
other	35121166	hsa-mir-760	Pre-Eclampsia	5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE.
other	35121166	hsa-mir-532	Pre-Eclampsia	5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE.
other	35121166	hsa-mir-188	Pre-Eclampsia	5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE.
genetics_overexpression_promote	35121085	hsa-mir-143	Urinary Bladder Neoplasms	The influence of miR-143 overexpression on BC cells migration, proliferation, and apoptosis was detected using wound-healing assay, MTT assay, and DAPI and Annexin V/PI staining, respectively.
other	35120971	hsa-mir-452	Allergic Airway Inflammation	5p provided an alternative approach for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
transcription factor target	35120580	hsa-mir-26a	Colonic Neoplasms	RESULTS: Cordycepin inhibited colon cancer cell proliferation by down-regulating MYC mRNA/protein expression and up-regulating miR-26a in both HCT116 and Caco-2 cells. CONCLUSION: Cordycepin is able to suppress colon cancer cell proliferation, likely mediated by the MYC/miR-26a pathway, supporting its potential for the treatment of colon cancer.
lncRNA target	35120571	hsa-mir-19a	Lupus Erythematosus, Systemic	CONCLUSIONS: The circGARS sponges miR-19a to regulate YTHDF2 expression to promote SLE progression through the A20/NF-kappaB axis and may act as an independent biomarker to help the treatment of SLE patients.
other	35120526	hsa-mir-140	Fibroadenoma	CONCLUSION: miR3p could become potential differential biomarker for BPT and FA.
other	35120526	hsa-mir-140	Phyllodes Tumor	CONCLUSION: miR3p could become potential differential biomarker for BPT and FA.
lncRNA target	35119849	hsa-mir-21	Central Nervous System Diseases	In this contribution, we demonstrate a palindrome-based hybridization chain reaction (PHCR) upon the stimuli of a short oligonucleotide trigger to perform the autonomous assembly of cross-linked network structures (CNSs) for the amplification detection of miRNA-21 and sensitive fluorescence imaging of cancerous cells. Utilizing the CHA-PHCR assay system, a small amount of miRNA-21 can activate many triggers via CHA and in turn induce the PHCR-based CNS assembly from more DNA building blocks, bringing Cy3 and Cy5 into close proximity to each other and generating ultrasensitive fluorescence resonance energy transfer signals.
lncRNA target	35119587	hsa-mir-9	Adenocarcinoma of Lung	5p fostered malignant behaviors of LUAD cells by targeting STARD13.
circulation_biomarker_diagnosis_down	35119164	hsa-mir-1304	Periodontitis	CONCLUSIONS: Plasma-derived exosomal miRs (miR
circulation_biomarker_diagnosis_down	35119164	hsa-mir-200c	Periodontitis	CONCLUSIONS: Plasma-derived exosomal miRs (miR
lncRNA target	35119030	hsa-mir-1	Diabetic Nephropathies	3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published.
lncRNA target	35119030	hsa-mir-23	Diabetic Nephropathies	3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published.
lncRNA target	35119030	hsa-mir-206	Diabetic Nephropathies	3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published.
other	35118954	hsa-mir-199	Epstein-Barr Virus Infections	We hypothesize that an EBV infection is responsible for the upregulation of the miRNA 199-3p, which binds to the 3'UTR of endothelin-1 (ET-1).
lncRNA target	35118606	hsa-mir-181	Necrosis	Our study provided evidence that Cd may act through miR5p/TNF-alpha to induce necroptosis in swine lung.
transcription factor target	35118493	hsa-mir-29b	Liver Cirrhosis	The present study attempts to reveal the effect and mechanism of XSSJS via regulating miR-29b-3p/VEGFA axis against pathological angiogenesis in HF. In conclusion, XSSJS could modulate miR-29b-3p/VEGFA axis to inhibit the pathological angiogenesis of HF.
other	35118144	hsa-mir-29	Cardiomyopathies	In vitro analysis of miR-29a effects on fibroblast and cardiac muscle cells pointed toward a protective role of miR-29a on aging-related fibrosis, by reducing cell migration and proliferation. In conclusion, our study indicates an adaptive increase of miR-29 in the natural aging process and suggests its role as a transcriptional repressor of SERPINH1, with a potential therapeutic value against adverse matrix remodeling and aging-associated tissue fibrosis.
other	35118144	hsa-mir-29a	Cardiomyopathies	In vitro analysis of miR-29a effects on fibroblast and cardiac muscle cells pointed toward a protective role of miR-29a on aging-related fibrosis, by reducing cell migration and proliferation. In conclusion, our study indicates an adaptive increase of miR-29 in the natural aging process and suggests its role as a transcriptional repressor of SERPINH1, with a potential therapeutic value against adverse matrix remodeling and aging-associated tissue fibrosis.
other	35118144	hsa-mir-18a	Cardiomyopathies	Among the miRNAs with documented roles in aging-related cardiac diseases, miR-18a, -21a, -22, and -29a were mainly associated with hypertrophy and/or fibrosis; however, their relationship to aging was not fully addressed before.
exosome	35118066	hsa-mir-486	Pituitary Neoplasms	In conclusion, exosomal hsa-miR
lncRNA target	35117926	hsa-mir-153	Melanoma	3p exhibited suppressive effects via directly binding and downregulating ATG5 expression, which subsequently increased sensitivity to dacarbazine and inhibited proliferation, and enhanced apoptosis and autophagy in melanoma cells.
circulation_biomarker_diagnosis_ns	35117918	hsa-mir-17	Adenocarcinoma of Lung	CONCLUSIONS: In conclusion, circulating miR-17 may be a quality diagnostic biomarker for LUAD screening, but confirmation by a large, rigorous clinical validation in a longitudinal setting is warranted.
lncRNA target	35117903	hsa-mir-101	Carcinoma, Hepatocellular	Finally, treatment of BEL-7402 cells, an HCC cell line, with miR101-loaded MSCs led to significant proliferation inhibition and apoptosis of BEL-7402 cells.
exosome	35117898	hsa-mir-150	Osteosarcoma	Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1.
target gene	35117890	hsa-mir-215	Colorectal Neoplasms	low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway.
target gene	35117886	hsa-mir-195	Thyroid Neoplasms	hsa-miR-195-5p inhibits cell proliferation of human thyroid carcinoma cells via modulation of p21/cyclin D1 axis.
lncRNA target	35117854	hsa-mir-448	Carcinoma, Ovarian Epithelial	CONCLUSIONS: Our study suggests that miR-448 has an inhibitory role in OC.
target gene	35117853	hsa-mir-214	Osteosarcoma	Formononetin inhibits osteosarcoma cell proliferation and promotes apoptosis by regulating the miR-214-3p/phosphatase and tensin homolog pathway.
target gene	35117808	hsa-mir-132	Ovarian Neoplasms	microRNA-132 inhibits the proliferation, migration, and invasion of ovarian cancer cells by regulating CT10 oncogenic gene homolog II-related signaling pathways.
genetics_knock down_promote	35117781	hsa-mir-494	Osteosarcoma	Gain of miR-494 function suppressed OS tumor growth and promoted apoptosis of OS cells, while loss of miR-494 inhibited apoptosis and promoted invasion of osteoblastic cells.
target gene	35117763	hsa-mir-7	Carcinoma, Hepatocellular	MicroRNA-7 inhibits hepatocellular carcinoma cell invasion and metastasis by regulating Atg5-mediated autophagy.
target gene	35117758	hsa-mir-152	Stomach Neoplasms	H19/miR-152-3p/TCF4 axis increases chemosensitivity of gastric cancer cells through suppression of epithelial-mesenchymal transition.
circulation_biomarker_prognosis_ns	35117730	hsa-mir-10a	Laryngeal Neoplasms	Lower serum level of microRNA-21 and higher serum level of microRNA-10a predict better prognosis in LSCC patients.
circulation_biomarker_prognosis_ns	35117730	hsa-mir-21	Laryngeal Neoplasms	CONCLUSIONS: The serum levels of microRNA-21 and microRNA-10a are associated with long-term prognosis in laryngeal cancer patients.
target gene	35117718	hsa-mir-567	Stomach Neoplasms	The miR-567/RPL15/TGF-β/Smad axis inhibits the stem-like properties and chemo-resistance of gastric cancer cells.
genetics_overexpression_promote	35117716	hsa-mir-106a	Prostatic Neoplasms	Overexpression of miR-106a in PCa cells triggered cell apoptosis and suppressed cell proliferation, migration, and invasion.
lncRNA target	35117684	hsa-mir-4428	Uterine Cervical Neoplasms	CONCLUSIONS: RGMB-AS1 regulated miR-4428/PBX1 axis to aggravate CC development, indicating that targeting RGMB-AS1 could be a potent way for developing the novel therapeutic methods for CC patients.
lncRNA target	35117649	hsa-mir-28	Colonic Neoplasms	5p plays an important role in ferroptosis by targeting N4BP1 and could serve as a potential therapeutic approach for colon cancer.
target gene	35117640	hsa-mir-378	Colorectal Neoplasms	MicroRNA-124 and microRNA-378 inhibit the proliferation and invasion of colorectal cancer by upregulating KiSS1.
target gene	35117640	hsa-mir-124	Colorectal Neoplasms	MicroRNA-124 and microRNA-378 inhibit the proliferation and invasion of colorectal cancer by upregulating KiSS1.
genetics_knock down_promote	35117631	hsa-mir-181	Osteosarcoma	CONCLUSIONS: IL-1beta secreted by M2-TAMs contributed to OS metastasis, which could be suppressed by knockdown of miR-181alpha-5p or overexpression of RASSF1A through NF-kappaB/miR-181alpha-5p/RASSF1A/Wnt pathway.
lncRNA target	35117624	hsa-mir-216a	Adenocarcinoma of Lung	Rescue experiment showed that miR-216a-3p inhibitor promoted cell viability, migration and invasion, and inhibited apoptosis of lung adenocarcinoma cells, partly reversed the effects of siCOPB2. CONCLUSIONS: High-expressed COPB2 promotes metastasis and inhibits apoptosis of lung adenocarcinoma cells through functioning as a target of miR-216a-3p.
other	35117623	hsa-mir-491	Colorectal Neoplasms	Interaction between linc01615 and miR-491-5p regulates the survival and metastasis of colorectal cancer cells.
exosome	35117617	hsa-mir-29b	Carcinoma, Hepatocellular	Exosomal miR-29b from cancer-associated fibroblasts inhibits the migration and invasion of hepatocellular carcinoma cells.
lncRNA target	35117607	hsa-mir-124	Bulimia Nervosa	This study was designed to study whether denosumab inhibits human BC cells (MCF-7) cell line-induced spontaneous osteoclastogenesis via RANKL/metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-124 axis.
lncRNA target	35117607	hsa-mir-124	Adenocarcinoma	This study was designed to study whether denosumab inhibits human BC cells (MCF-7) cell line-induced spontaneous osteoclastogenesis via RANKL/metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-124 axis.
genetics_overexpression_suppress	35117532	hsa-mir-193b	Tongue Neoplasms	MiR-193b-5p mimics were transfected into tongue cancer cell lines CAL27 and TCA-8113 to generate miR-193b-5p overexpression cells.
target gene	35117528	hsa-mir-574	Pancreatic Neoplasms	LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p.
target gene	35117524	hsa-mir-26a	Carcinoma, Non-Small-Cell Lung	miRNA-26a blocks interleukin-2-mediated migration and proliferation of non-small cell lung cancer cells via vascular cell adhesion molecule-1.
lncRNA target	35117516	hsa-mir-93	Urinary Bladder Neoplasms	CONCLUSIONS: lncRNA MEG3 could function as a competing endogenous RNA of miR-93 to regulate the tumorigenesis of BC via PI3K/AKT/mTOR pathway.
transcription factor target	35117503	hsa-mir-378a	Carcinoma, Hepatocellular	CONCLUSIONS: miR-378a-5p improved the HCC prognosis and suppressed HCC progression by targeting the VEGF pathway.
other	35117497	hsa-mir-877	Multiple Myeloma	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-449c	Multiple Myeloma	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-449c	Kidney Diseases	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-103a	Multiple Myeloma	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-877	Kidney Diseases	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-103a	Kidney Diseases	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-let-7a	Kidney Diseases	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-let-7a	Multiple Myeloma	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-455	Multiple Myeloma	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
other	35117497	hsa-mir-455	Kidney Diseases	3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients.
circulation_biomarker_diagnosis_up	35117494	hsa-mir-643	Thyroid Cancer, Papillary	Patients with larger diameter tumors or moderate-poorly differentiated tumors were more likely to have higher miR-643 expression levels in both PTC tissue and serum.
target gene	35117490	hsa-mir-185	Pancreatic Neoplasms	LncRNA XIST acts as a ceRNA sponging miR-185-5p to modulate pancreatic cancer cell proliferation via targeting CCND2.
circulation_biomarker_prognosis_down	35117475	hsa-mir-596	Stomach Neoplasms	The MTT assay assessed MNK28 and SGC7901 cell proliferation after transfection with miR-596 plasmids.
lncRNA target	35117454	hsa-mir-148b	Endometrial Neoplasms	Importantly, we determined that DNMT1 is a target gene of miR-148b in EC cells, and silencing of DNMT1 reversed the effects of miR-148b inhibitor on cell proliferation, cell cycle progression, and apoptosis in EC.
lncRNA target	35117441	hsa-mir-543	Nasopharyngeal Carcinoma	RESULTS: The results showed that MEG3 was decreased and miR-543 was increased in NPC cell lines, and upregulated MEG3 inhibited cell proliferation, migration, and invasion and promoted apoptosis, suggesting that MEG3 acts as a tumor suppressor in NPC cells.
other	35117431	hsa-mir-4284	Prostatic Neoplasms	Two miRNAs (hsa-miR-428 and hsa-miR-4284) involve in PCa by regulating BMP5-BAMBI interaction and TGF-beta signaling pathway.
other	35117431	hsa-mir-428	Prostatic Neoplasms	Two miRNAs (hsa-miR-428 and hsa-miR-4284) involve in PCa by regulating BMP5-BAMBI interaction and TGF-beta signaling pathway.
other	35117416	hsa-mir-24	Urinary Bladder Neoplasms	microRNA-324 plays an oncogenic role in bladder cancer cell growth and motility.
other	35117412	hsa-mir-425	Carcinoma, Endometrioid	Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05).
other	35117412	hsa-mir-425	Uterine Neoplasms	Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05).
other	35117412	hsa-mir-211	Carcinoma, Endometrioid	Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05).
other	35117412	hsa-mir-211	Uterine Neoplasms	Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05).
other	35117358	hsa-mir-504	Uterine Cervical Neoplasms	HPV16 E6 regulates the proliferation, invasion, and apoptosis of cervical cancer cells by downregulating miR-504.
other	35117327	hsa-mir-449a	Esophageal Squamous Cell Carcinoma	Down-regulation of miR-449a-5p promoted the proliferation of ESCC cells.
other	35117327	hsa-mir-449a	Esophageal Neoplasms	Down-regulation of miR-449a-5p promoted the proliferation of ESCC cells.
target gene	35117325	hsa-mir-143	Urinary Bladder Neoplasms	Long noncoding RNA MAFG-AS1 facilitates bladder cancer tumorigenesis via regulation of miR-143-3p/SERPINE1 axis.
target gene	35117305	hsa-mir-185	Stomach Neoplasms	MiR-185-3p regulates epithelial mesenchymal transition via PI3K/Akt signaling pathway by targeting cathepsin D in gastric cancer cells.
genetics_GWAS	35117288	hsa-mir-146a	Lung Neoplasms	RESULTS: In conclusion, the frequency of miR-146a GC genotype mutation in normal people and patients with lung cancer is 44% and 47% respectively and the rate of miR-146a CC genotype mutation in the normal people and patients with lung cancer is 17% and 22% respectively. What's more, the frequency of miR-146a C allele mutation in normal people and patients with lung cancer is 40% and 46% respectively.
target gene	35117240	hsa-mir-137	Stomach Neoplasms	EDIL3 regulates gastric cancer cell migration, invasion and epithelial-mesenchymal transition via TGF-β1/XIST/miR-137 feedback loop.
other	35117225	hsa-mir-34a	Leukemia, Lymphocytic, Chronic, B-Cell	Up-regulated expression of miR-34a or down-regulated expression of MDM4 could increase apoptosis of CLL cells
lncRNA target	35117177	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: These results indicated that BMSCs could blocked the proinflammatory pathway of macrophage through miR-21 over-expression, thus could be a potential therapeutic strategy for RILI.
circulation_biomarker_prognosis_ns	35117168	hsa-mir-138	Stomach Neoplasms	5p expression in cancer tissues or plasma could be a useful predictive biomarker for the efficacy of platinum-based chemotherapy and prognoses in advanced gastric cancer patients.
other	35117163	hsa-mir-486	Carcinoma, Non-Small-Cell Lung	miR-486 could be used as an unfavorable prognostic biomarker for NSCLC patients.
transcription factor target	35117048	hsa-mir-29c	Colorectal Neoplasms	Last but not least, we analyzed the TargetScan dataset and found that Girdin was a regulated target of hsa-miR-29c-3p in CRC. CONCLUSIONS: Our fi ndings suggest that Girdin has a crucial role in CRC progression via miR-29c-3p/Girdin axis, highlighting Girdin as a therapeutic target for CRC.
target gene	35117036	hsa-mir-203a	Esophageal Neoplasms	miR-203a-3p regulates the cellular processes of esophageal cancer cells via targeting CtBP2.
target gene	35117034	hsa-mir-145	Colonic Neoplasms	LncRNA CASC9 regulates cell proliferation, apoptosis and cell cycle via sponging miR-145-5p in colon cancer cells.
other	35117029	hsa-mir-200c	Urinary Bladder Neoplasms	MicroRNA-200c affects bladder cancer angiogenesis by regulating the Akt2/mTOR/HIF-1 axis.
other	35117027	hsa-mir-4705	Stomach Neoplasms	Furthermore, hsa-mir-4705 (miRNA) and BMPR1B (mRNA) at the downstream of hsa_circ_0067934 were found differentially expressed in gastric cancer by expression data from TCGA database. Moreover, we discovered that the hsa_circ_0067934/hsa-mir-4705/BMPR1B axis might be involved in the carcinogenesis of gastric cancer.
genetics_knock down_promote	35117016	hsa-mir-139	Colonic Neoplasms	5p were found in circ-STAT3.46 knockdown cells.
genetics_knock down_promote	35117009	hsa-mir-505	Leukemia, Myeloid, Acute	CONCLUSIONS: Lnc-MVIH knockdown inhibits cell proliferation but promotes cell apoptosis via regulating miR-505 mediated HMGB1 and CCNE2 in AML.
target gene	35116999	hsa-mir-497	Carcinoma, Non-Small-Cell Lung	MicroRNA-497-5p negatively regulates the proliferation and cisplatin resistance of non-small cell lung cancer cells by targeting YAP1 and TEAD1.
epigenetics	35116985	hsa-mir-34a	Osteosarcoma	The regulatory role of aberrant methylation of microRNA-34a promoter CpGs in osteosarcoma.
lncRNA target	35116967	hsa-mir-29b	Adrenocortical Carcinoma	Finally, through Kaplan-Meier survival analysis, we identified five lncRNAs (LINC00887, MEIS1-AS2, MIR29B2CHG, MIR503HG, and SREBF2-AS1) associated with prognosis in patients with ACC.
lncRNA target	35116967	hsa-mir-503	Adrenocortical Carcinoma	Finally, through Kaplan-Meier survival analysis, we identified five lncRNAs (LINC00887, MEIS1-AS2, MIR29B2CHG, MIR503HG, and SREBF2-AS1) associated with prognosis in patients with ACC.
lncRNA target	35116964	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	3p/ROCK2 signaling in cisplatin resistance of NSCLC cells.
target gene	35116952	hsa-mir-204	Melanoma	MicroRNA-204-3p modulates epithelial-mesenchymal transition by targeting paired box gene 2 in human melanoma A-375 cells.
target gene	35116927	hsa-let-7a	Breast Neoplasms	MicroRNA let-7a inhibits proliferation of breast cancer cell by downregulating USP32 expression.
other	35116921	hsa-mir-21	Thyroid Cancer, Papillary	Multivariate logistic regression confirmed the association between miR-138/miR-21 expression and PTC diagnosis.
other	35116921	hsa-mir-138	Thyroid Cancer, Papillary	METHODS: miR-138/miR-21 expression was tested in 101 PTC and 51 benign thyroid nodule (control) patients using quantitative real-time PCR.
other	35116873	hsa-mir-21	Carcinoma, Hepatocellular	BACKGROUND: This study was conducted to investigate the effects of c[RGDyk]-coated liposomes loaded with Adriamycin (nanodrug) and miR-21 mimics on hepatoma cell line SMCC-7721.
lncRNA target	35116871	hsa-mir-221	Colonic Neoplasms	To uncover potential targets for treatment, the present study investigated PDZRN4 in colon cancer development, and explored the role of miR
lncRNA target	35116858	hsa-mir-222	Thyroid Cancer, Papillary	CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma.
lncRNA target	35116858	hsa-mir-214	Thyroid Cancer, Papillary	CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma.
lncRNA target	35116858	hsa-mir-34a	Thyroid Cancer, Papillary	CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma.
lncRNA target	35116858	hsa-mir-138-2	Thyroid Cancer, Papillary	CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma.
lncRNA target	35116858	hsa-mir-221	Thyroid Cancer, Papillary	CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma.
lncRNA target	35116852	hsa-mir-17	Colonic Neoplasms	Furthermore, the Wnt/beta-catenin signaling, activated by miR-17 and miR-18a, was required for the oncogenic role of MIR17HG in colon cancer. CONCLUSIONS: MIR17HG mediated upregulation of miR-17 and miR-18a promotes the progression of colon cancer via activating Wnt/beta-catenin signaling.
lncRNA target	35116852	hsa-mir-18a	Colonic Neoplasms	Furthermore, the Wnt/beta-catenin signaling, activated by miR-17 and miR-18a, was required for the oncogenic role of MIR17HG in colon cancer. CONCLUSIONS: MIR17HG mediated upregulation of miR-17 and miR-18a promotes the progression of colon cancer via activating Wnt/beta-catenin signaling.
lncRNA target	35116817	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	Moreover, in consideration of the meta-analysis, 1,012 clinical specimens were systematically analyzed via meta-analysis, clinical specimens were systematically analyzed via meta-analysis, and the results showed that the expression of miR
target gene	35116797	hsa-mir-451	Prostatic Neoplasms	MiR-451 suppresses the growth, migration, and invasion of prostate cancer cells by targeting macrophage migration inhibitory factor.
genetics_overexpression_promote	35116795	hsa-mir-210	Carcinoma, Hepatocellular	Moreover, miR-210 overexpression prevented the effects of cisplatin and rescued HCC cell growth, and miR-210 inhibition contributed to improved chemosensitivity of cisplatin in HCC cells.
genetics_overexpression_promote	35116786	hsa-mir-1290	Chordoma	RESULTS: In vitro functional analysis, including clone formation, and Transwell assays indicated overexpression of miR-1290 significantly suppressed chordoma cell proliferation and invasion.
target gene	35116709	hsa-mir-23a	Carcinoma, Non-Small-Cell Lung	Long non-coding RNA ZNF674-AS1 regulates miR-23a/E-cadherin axis to suppress the migration and invasion of non-small cell lung cancer cells.
lncRNA target	35116702	hsa-mir-134	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p conferred protection against TNF-alpha-induced mucus hypersecretion through repressing NF-kappaB and p38 MAPK signaling, indicating that miR
lncRNA target	35116702	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	5p and miR-146a-5p conferred protection against TNF-alpha-induced mucus hypersecretion through repressing NF-kappaB and p38 MAPK signaling, indicating that miR
other	35116678	hsa-mir-204	Colorectal Neoplasms	Downregulating miR-204 expression plays a vital role in upregulating ANGPTL2 expression and promoting the pathogenesis of CRC.
genetics_overexpression_promote	35116677	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	5p were overturned by overexpression of DLX6-AS1 or BMI1 in NSCLC cells.
lncRNA target	35116675	hsa-mir-137	Uterine Cervical Neoplasms	CONCLUSIONS: MiR-137 targets Notch1 and regulates CC through the PI3K/Akt/mTOR pathway.
genetics_knock down_suppress	35116658	hsa-mir-138	Colorectal Neoplasms	We also found that the level of SIRT1 in CRC tissues and cell lines is higher, and through Dual-luciferase reporter assay, we found that SIRT1 is a new target of miR-138 in CRC, and SIRT1 knockdown could inhibit CRC proliferation, migration and invasion in vitro.
target gene	35116655	hsa-mir-339	Stomach Neoplasms	MiRNA-339 targets and regulates ZNF689 to inhibit the proliferation and invasion of gastric cancer cells.
circulation_biomarker_prognosis_ns	35116650	hsa-mir-27a	Carcinoma, Non-Small-Cell Lung	Serum miR-27a is a biomarker for the prognosis of non-small cell lung cancer patients receiving chemotherapy.
other	35116608	hsa-mir-134	Carcinoma, Hepatocellular	CONCLUSIONS: In summary, propofol appears to upregulate the expression level of miR-134, decrease the BCL-2 level, and induce HCC cell apoptosis by promoting the cleaved caspase-3 expression level.
genetics_overexpression_promote	35116581	hsa-mir-19a	Esophageal Squamous Cell Carcinoma	CONCLUSIONS: Overexpression of miR-19a-3p increased the invasion and migration of ESCC cells via the RAC1/CDC42-PAK1 pathway, suggesting that this pathway mediates the effect of miR-19a-3p on promoting LNM in ESCC.
transcription factor target	35116553	hsa-mir-7	Carcinoma, Ovarian Epithelial	The evidence showed that miR7 functioning as a tumor suppressor gene in EOC.
other	35116508	hsa-mir-138	Glioma	In summary, the CircWEE1/miR-138 axis may regulate SIRT1 to promote malignant progression in glioma.
circulation_biomarker_diagnosis_ns	35116507	hsa-mir-126	Mesothelioma, Malignant	Considering that the available studies have a high risk of bias, further rigorous studies are needed to assess the diagnostic value of circulating miR-126 for MPM.
target gene	35116505	hsa-mir-30	Carcinoma, Hepatocellular	3p may inhibit AQP9 expression in HCC.
target gene	35116505	hsa-mir-23a	Carcinoma, Hepatocellular	3p may inhibit AQP9 expression in HCC.
target gene	35116434	hsa-mir-221	Glioblastoma	MicroRNA-221 promotes tumor progression by targeting HHIP in human glioblastoma.
genetics_overexpression_suppress	35116432	hsa-mir-19a	Multiple Myeloma	The effects of miR-19a-3p on cell proliferation, migration, and invasion in U226 and RPMI-8226 MM cells were evaluated by miR-19a-3p overexpression.
circulation_biomarker_diagnosis_ns	35116424	hsa-mir-210	Carcinoma, Hepatocellular	MCP-1 and miR-210 levels were measured in 40 HCC patients at baseline before TACE and compared with 17 healthy controls by immunoassay and reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). RESULTS: The serum MCP-1 and miR-210 levels were significantly elevated in HCC patients compared to healthy subjects.
lncRNA target	35116405	hsa-mir-516b	Retinoblastoma	Moreover, TUG1 could bind with miR-516b-5p, which targeted H6PD in RB.
circulation_biomarker_prognosis_up	35116367	hsa-mir-203	Esophageal Squamous Cell Carcinoma	Moreover, the serum level of miR-25/miR-203 in 57 ESCC patients was higher than that in 31 healthy volunteers.
circulation_biomarker_prognosis_up	35116367	hsa-mir-25	Esophageal Squamous Cell Carcinoma	Moreover, the serum level of miR-25/miR-203 in 57 ESCC patients was higher than that in 31 healthy volunteers.
target gene	35116366	hsa-mir-625	Carcinoma, Non-Small-Cell Lung	Long non-coding RNA LINC00511 promotes proliferation, invasion, and migration of non-small cell lung cancer cells by targeting miR-625-5p/GSPT1.
other	35116358	hsa-mir-29a	Breast Neoplasms	Furthermore, we first predicted miR-29a-3p was a potential upstream regulator of SETDB1 in BRCA. CONCLUSIONS: This study suggested that miR-29a-3p can mediate the expression of SETDB1 with poor prognosis and tumor immune infiltration in BRCA.
transcription factor target	35116342	hsa-mir-425	Lymphoma, Large B-Cell, Diffuse	5p is responsible for the oncogenic progression and relapse of DLBC tumorigenesis via PTEN/PI3K signaling, which can thus be effectively used to achieve better therapeutic outcomes.
target gene	35116341	hsa-mir-20a	Ovarian Neoplasms	LINC00641 inhibits the proliferation and invasion of ovarian cancer cells by targeting miR-320a.
other	35116336	hsa-mir-15a	Carcinoma, Endometrioid	Furthermore, the expression of miR-15a-5p was significantly decreased in endometrial cancer patients with recurrence or metastasis and thus, miR-15a-5p may have certain value in predicting postoperative recurrence or metastasis in such patients.
target gene	35116334	hsa-mir-199a	Breast Neoplasms	Dexmetomidine promotes the activity of breast cancer cells through miR-199a/HIF-1α axis.
other	35116328	hsa-mir-218	Glioblastoma	C10orf25/miR-218/DCBLD2 may be an important regulatory pathway in GBM. C10orf25/miR-218/DCBLD2 may be an important regulatory pathway associated with the pathogenesis of GBM.
lncRNA target	35116306	hsa-mir-10b	Carcinoma, Renal Cell	CONCLUSIONS: Our findings suggest that SNHG3 plays a vital role in promoting ccRCC via the microRNA-10b-5p/BIRC5 axis and may serve as a novel therapeutic target for the treatment of patients with ccRCC.
other	35116269	hsa-mir-3176	lung squamous cell carcinoma	RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma.
other	35116269	hsa-mir-2278	lung squamous cell carcinoma	RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma.
other	35116269	hsa-mir-654	lung squamous cell carcinoma	RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma.
other	35116241	hsa-mir-196b	Adenocarcinoma of Lung	We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC.
other	35116241	hsa-mir-223	Adenocarcinoma of Lung	We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC.
other	35116241	hsa-mir-196a	Adenocarcinoma of Lung	We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC.
lncRNA target	35116239	hsa-mir-133b	Colorectal Neoplasms	The result of our previous research has found a statistically significant downregulation of microRNA-133b expression in human CRC cells, microRNA-133b can block the growth and metastatic progression of CRC cells in vitro and in vivo by targeting and repressing mesenchymal to epithelial transition factor.
other	35116078	hsa-mir-138	Hypertension, Pulmonary	Furthermore, bioinformatics and Luciferase assay showed that circWDR37 directly sponged hsa-miR5p (miR-138) and was involved in the immunoregulatory and inflammatory processes of PAH.
lncRNA target	35116071	hsa-mir-32	Colonic Neoplasms	5p/PER2/CRY2 regulatory axis in COAD was also detected through a mRNA-miRNA-lncRNA network.
circRNA target	35116004	hsa-mir-144	Diabetes Mellitus, Type 2	CONCLUSION: hsa_circ_0111707 is associated with risk of T2D development via sponging miR3p.
exosome	35115831	hsa-mir-204	Ovarian Neoplasms	Exosomal lncRNA ATB Derived from Ovarian Cancer Cells Promotes Angiogenesis via Regulating miR-204-3p/TGFβR2 Axis.
circulation_biomarker_prognosis_up	35115787	hsa-mir-362	Nasopharyngeal Carcinoma	3p expression was decreased in the serum and tissues of NPC patients and had diagnostic value for screening NPC.
genetics_overexpression_promote	35115487	hsa-mir-214	Squamous Cell Carcinoma of Head and Neck	Notably, overexpression of LINC01123 or B7-H3 or downregulation of miR
other	35114922	hsa-mir-335	Alzheimer Disease	The topological analyses of the constructed regulatory networks suggested that TF - FOXC1 and miRNA - hsa-mir5p might be vital co-regulators of gene expression in AD and epilepsy.
other	35114922	hsa-mir-335	Epilepsy	The topological analyses of the constructed regulatory networks suggested that TF - FOXC1 and miRNA - hsa-mir5p might be vital co-regulators of gene expression in AD and epilepsy.
circRNA target	35114894	hsa-mir-98	Cerebral Infarction, Acute	Furthermore, acyl-CoA synthetase long-chain family member 4 (ACSL4) was confirmed to be a downstream target of miR
genetics_overexpression_promote	35114891	hsa-mir-1294	Carcinoma, Non-Small-Cell Lung	And circPLK1 overexpression facilitates the progression of NSCLC by negatively regulating miR-1294 level and maintaining a high-level expression of HMGA1 (High Mobility Group Protein A1). Our study suggests that circPLK1 upregulation plays an important role in NSCLC progression by targeting miR-1294/HMGA1 axis.
virus_miRNA	35114606	ebv-mir-BHRF1-2	Multiple Sclerosis	ebv-miR-BHRF1-2-5p directly targeting MALT1
virus_miRNA	35114606	ebv-mir-BART11	Multiple Sclerosis	ebv-miR-BART11 directly targeting FOXP1
genetics_overexpression_promote	35114192	hsa-mir-6874	Osteosarcoma	3p overexpression markedly inhibited the progression of OS cells.
other	35114139	hsa-mir-9	Inflammation	The present study aimed to investigate the expression of miR9 and its correlation with cytokines, proteolytic enzymes and apoptosis in an experimental model of 6-mer HA induced inflammation in human chondrocytes. We suggested that the up regulation of miR9, induced by 6-mer HA, could be a cellular attempt to limit cell damage during inflammation.
lncRNA target	35113786	hsa-mir-628	Glioma	5p in glioma cells as the biological functions of DLGAP1-AS1 are partially mediated via miR
other	35113418	hsa-mir-18	Myocardial Infarction	5p) in myocardial infarction (MI) and its potential mechanism.
transcription factor target	35113417	hsa-mir-486	Myocardial Ischemia	Therefore, miR-486 may become a new target for myocardial IRI therapy.
transcription factor target	35113417	hsa-mir-486	Iris Diseases	Therefore, miR-486 may become a new target for myocardial IRI therapy.
transcription factor target	35113040	hsa-mir-29	Leiomyoma	Furthermore, miR-29 inhibitors promoted the protein expression of MMP-2 and MMP-9 (P < 0.01), and EMT promoting proteins N-cadherin, snail, vimentin, and Transwell assay showed that miR-29 inhibitors promoted cell migration in uterine leiomyoma (P < 0.01).
genetics_knock down_suppress	35113007	hsa-mir-193a	Squamous Cell Carcinoma of Head and Neck	In conclusion, these findings suggest that knockdown of AGAP2-AS1 inhibited the proliferation and invasion of LSCC cells through regulating the miR-193a-3p/LOXL4 axis.
lncRNA target	35113000	hsa-mir-146a	Cerebral Hemorrhage	All the effects of MALAT1-shRNA on ICH rats were reversed by miR-146a inhibitor co-treatment.
genetics_knock down_promote	35112991	hsa-mir-1225	Breast Neoplasms	3p overexpression worked oppositely.
lncRNA target	35112985	hsa-mir-190a	Uterine Cervical Neoplasms	KLF6 was a target of miR-190a-3p and inhibited miR-190a-3p-induced CC tumor growth.
lncRNA target	35112982	hsa-mir-19a	Osteosarcoma	Furthermore, we found that miR-19a-3p might exert its oncogenic function by inhibiting PHLDA3 expression in osteosarcoma. These results demonstrated miR-19a-3p/ PHLDA3/ Akt/GSK3beta axis has a pivotal role in osteosarcoma, and PHLDA3 is a prospective therapeutic target for treating osteosarcoma.
lncRNA target	35112981	hsa-mir-146a	Sepsis	Therefore, GAS5 is downregulated in sepsis-ALI and inhibits cell apoptosis by up-regulating the expression of miR-146a.
lncRNA target	35112981	hsa-mir-146a	Acute Lung Injury	Therefore, GAS5 is downregulated in sepsis-ALI and inhibits cell apoptosis by up-regulating the expression of miR-146a.
genetics_overexpression_suppress	35112979	hsa-mir-212	Arthritis, Rheumatoid	In conclusion, TSPEAR-AS2 is downregulated in RA and its overexpression can decrease the apoptosis of RA HFLSs by downregulating miR
lncRNA target	35112970	hsa-mir-335	Sepsis	Based on our results, it seemed that YY1-activated LINC00472 might contribute to SICD progression via the miR3p/MAOA pathway.
transcription factor target	35112252	hsa-mir-21	Carcinoma, Renal Cell	5p, a stimulator in RCC, and it deteriorated this cancer via repressing its downstream target gene ARHGAP24 expression.
circulation_biomarker_diagnosis_up	35111850	hsa-mir-148a	Breast Neoplasms	Serum levels of miR
circulation_biomarker_diagnosis_ns	35111850	hsa-mir-9	Breast Neoplasms	Serum miR5p levels were markedly higher in patients with human epidermal growth factor receptor 2- (HER2-) positive breast cancer than in those with HER2-negative breast cancer (P = 0.049).
lncRNA target	35111808	hsa-let-7b	Intervertebral Disc Degeneration	Results suggested that NPSC-exo exacerbated cell degeneration of AFCs via let-7b-5p, accompanied by inhibition of IGF1R expression, and PI3K-Akt pathway activation.
lncRNA target	35111759	hsa-mir-223	Cardiotoxicity	3p mimic exhibits potential value in the treatment of RIHD.
other	35111747	hsa-mir-409	Parkinson Disease	3p in CSF as a diagnostic marker of PD.
circulation_biomarker_prognosis_up	35111539	hsa-mir-489	Cardiomyopathy, Dilated	Additionally, the quantification of circulating miR-489 may have value as a potential prognostic marker for patients with DCM.
target gene	35111226	hsa-mir-652	Osteosarcoma	miR-652 Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting HOXA9 and Regulating the PI3K/Akt Signaling Pathway.
transcription factor target	35111054	hsa-mir-671	Wilms Tumor	5p) plays a crucial role in mediating beta-catenin-triggered podocyte injury by targeting Wilms tumor 1 (WT1).
lncRNA target	35111054	hsa-mir-671	Proteinuria	Targeting miR
transcription factor target	35111054	hsa-mir-671	Nephrosclerosis	In contrast, miR5p antagomir alleviated podocyte injury and attenuated proteinuria and renal fibrotic lesions after glomerular injury in vivo.
transcription factor target	35110471	hsa-mir-17	Acute Lung Injury	FA inhibits PMVECs apoptosis induced by LPS via miR-17/PTEN to further regulate the activation of the PI3K/Akt pathway in ALI.
transcription factor target	35110470	hsa-mir-128	Neurotoxicity Syndromes	3p might be a potential therapeutic target for the prevention or treatment of sevoflurane-induced neurotoxicity by targeting with NOVA1.
transcription factor target	35110406	hsa-mir-27a	Triple Negative Breast Neoplasms	The DEL-derived pri-miR-27a ligand was cell active, potently and selectively inhibiting pri-miR-27a processing to reprogram gene expression and halt an otherwise invasive phenotype in triple-negative breast cancer cells.
lncRNA target	35109849	hsa-mir-506	Prostatic Neoplasms	3p is downregulated in prostate cancer cell lines and functions as a tumor suppressor.
epigenetics	35109842	hsa-mir-494	Breast Neoplasms	DNMT1 induced methylation of MEG3 promoter, and played a key role in breast cancer growth through miR-494-3p/OTUD4 axis.
lncRNA target	35109802	hsa-mir-138	autosomal recessive congenital bilateral absence of vas deferens	5p can act as a positive regulator of osteogenic differentiation in CAVD patients to involve in inhibiting valve calcification, which is achieved through RUNX2 and Wnt/beta-catenin signaling pathway.
circulation_biomarker_diagnosis_ns	35109781	hsa-mir-192	Hepatitis B, Chronic	3p positively correlated with the serum levels of HBV DNA and HBsAg.
lncRNA target	35109756	hsa-mir-96	Coronary Artery Disease	5p would ameliorate AMI-associated cardiomyocytes injury by targeting BCL2L13, hence contributing to the clinical treatment of AMI-CAD.
lncRNA target	35109756	hsa-mir-96	Myocardial Infarction, Acute	5p would ameliorate AMI-associated cardiomyocytes injury by targeting BCL2L13, hence contributing to the clinical treatment of AMI-CAD.
transcription factor target	35108712	hsa-mir-126	Parkinson Disease	CONCLUSION: Our results suggested that miR5p attenuated the neurotoxicity induced by MPP+ in vitro through targeting SP1 (Graphical abstract), which further enhanced our understanding of the pathological mechanism of PD.
circulation_biomarker_diagnosis_up	35108421	hsa-mir-448	Lupus Erythematosus, Systemic	3p level were observed in peripheral blood mononuclear cells (PBMCs) from SLE patients.
other	35108097	hsa-mir-573	Acute Lung Injury	Our study provides a novel insight into miRmediated regulation of endothelial function during DENV2 infection, which can be further translated into a potential therapeutic and prognostic agent for severe dengue patients.
other	35108097	hsa-mir-573	Dengue	Our study provides a novel insight into miRmediated regulation of endothelial function during DENV2 infection, which can be further translated into a potential therapeutic and prognostic agent for severe dengue patients.
lncRNA target	35107852	hsa-mir-206	Ovarian Neoplasms	We tested the hypothesis that miR-206 and mir-26b, emerging onco-suppressors targeting PFKFB3 in estrogen-dependent tumors, would regulate proliferation and migration of serous epithelial ovarian cancer (EOC) cells via common glycolytic proteins, i.e., GLUT1 and PFKFB3, and downstream FAK. Overall, these results support the inverse relation between endogenous miRNA levels and their tumor-suppressive effects and suggest that restoring miR-206 expression represents a potential dual anti-PFKFB3/FAK strategy to control ovarian cancer progression.
lncRNA target	35107852	hsa-mir-26b	Ovarian Neoplasms	We tested the hypothesis that miR-206 and mir-26b, emerging onco-suppressors targeting PFKFB3 in estrogen-dependent tumors, would regulate proliferation and migration of serous epithelial ovarian cancer (EOC) cells via common glycolytic proteins, i.e., GLUT1 and PFKFB3, and downstream FAK.
lncRNA target	35107755	hsa-mir-194	Squamous Cell Carcinoma of Head and Neck	5p/MTFR1 axis promotes TGFbeta1-induced EMT, migration and invasion of cells in TSCC, which could be potential targets for treating TSCC patients.
lncRNA target	35107754	hsa-mir-29a	Colorectal Neoplasms	CBR3-AS1 is downregulated in CRC and inhibits miR-29a-mediated cell migration and invasion by sponging miR-29a.
other	35107490	hsa-mir-203a	Pancreatic Carcinoma	The miR-203a-3p is involved in the stimulation of epithelial-to-mesenchymal transition (EMT) and is related to worse OS in pancreatic cancer (TCGA data).
genetics_knock down_promote	35106926	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Circ-RAD23B knockdown inhibited NSCLC development by regulating the miR3p/MAP4K3 axis, which might be associated with the inactivation of the MAPK signaling pathway.
genetics_knock down_promote	35106879	hsa-mir-944	Carcinoma, Non-Small-Cell Lung	Functionally, circ_0072088 knockdown improved CDDP sensitivity and repressed NSCLC cell malignancy, whereas miR-944 inhibitor hindered these effects.
lncRNA target	35106863	hsa-mir-125a	Breast Neoplasms	CONCLUSIONS: HOXA11-AS regulates the tumorigenic ability of BC via the miR-125a-5p/TMPRSS4 axis.
circulation_biomarker_prognosis_up	35106794	hsa-mir-183	Cholangiocarcinoma	Finally, clinical data showed that up-regulated levels of plasma exosomal miR
other	35105862	hsa-mir-29a	Brain Diseases	We identified miR-29a-3p and miR3p as novel and robust contributors to cognitive trajectory independently of the eight known cerebral pathologies.
other	35105862	hsa-mir-132	Brain Diseases	We identified miR-29a-3p and miR3p as novel and robust contributors to cognitive trajectory independently of the eight known cerebral pathologies.
other	35104452	hsa-mir-34c	Cicatrix	Here, we identify a p53-induced lncRNA suicidal PARP-1 cleavage enhancer (SPARCLE) adjacent to miR-34b/c required for p53-mediated apoptosis.
other	35104452	hsa-mir-34b	Cicatrix	Here, we identify a p53-induced lncRNA suicidal PARP-1 cleavage enhancer (SPARCLE) adjacent to miR-34b/c required for p53-mediated apoptosis.
other	35104050	hsa-mir-203	Myocardial Infarction, Acute	CONCLUSIONS: miR3p availability is antagonized by Snhg8 for Postn and Vegfa-induced AMI progression.
circRNA target	35103839	hsa-mir-27a	Osteoarthritis	CONCLUSION: CircTMOD3 suppresses miR-27a maturation in OA to promote chondrocyte apoptosis induced by LPS.
circRNA target	35103833	hsa-mir-126	Carcinoma, Endometrioid	5p, negatively regulating MACC1 expression, was a functional target of circ_0002577 in EC cells.
lncRNA target	35103493	hsa-mir-140	Osteoarthritis	CONCLUSION: CircSCAPER promoted IL-1beta-evoked ECM degradation, proliferation arrest, and apoptosis enhancement in chondrocytes via regulating miR3p/EZH2 axis, which gained a new insight into the pathogenesis of OA.
circulation_biomarker_diagnosis_ns	35103454	hsa-mir-21	Diabetic Nephropathies	CONCLUSIONS: We suggest the potential of serum GDF15 and circulating-hsa-miR-21 to serve as clinically important biomarkers and therapeutic targets for controlling advancement of diabetes to DN.
circulation_biomarker_diagnosis_ns	35103454	hsa-mir-21	Diabetes Mellitus, Type 2	CONCLUSIONS: We suggest the potential of serum GDF15 and circulating-hsa-miR-21 to serve as clinically important biomarkers and therapeutic targets for controlling advancement of diabetes to DN.
other	35103365	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: The expression profile and functions of miR-145 in canine oral SCC are similar to those in human HNSCC.
genetics_overexpression_promote	35103069	hsa-mir-10b	Colorectal Neoplasms	Rescue experiments showed that overexpressed miR-10b could reverse GAS5-mediated antitumor effect on CRC cells in vivo and in vitro.
genetics_overexpression_promote	35102025	hsa-mir-106b	Esophageal Neoplasms	miR-106b-5p mimics reversed the effect of CPEB3 overexpression on KYSE150 cells, and miR-106b-5p inhibitor reversed the effect of siRNA-CPEB3 on EC9706 cells. CPEB3 overexpressed by miR-106b-5p inhibition suppressed EC progression involved in EGFR and STAT3 signaling.
transcription factor target	35101688	hsa-mir-133a	Carcinoma, Non-Small-Cell Lung	Collectively speaking, luteolin inhibits the migration and invasion of NSCLC-VECs via miR-133a-3p/PURB- mediated MAPK and PI3K/Akt pathways.
other	35101680	hsa-mir-204	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101680	hsa-mir-181a	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101680	hsa-mir-212	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101680	hsa-mir-202	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101680	hsa-mir-182	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101680	hsa-mir-27a	Li-Fraumeni Syndrome	5p were significantly downregulated.
other	35101080	hsa-mir-431	Colonic Neoplasms	CONCLUSION: Taken together, the findings of the present study indicated that circCSPP1 may function as a competing endogenous RNA in the progression of colon cancer by regulating the miR-431/ROCK1 and miR-431/ZEB1 signaling axes.
genetics_knock down_promote	35101035	hsa-mir-138	Colorectal Neoplasms	5p could offset the repressed function of LINC00665 knockdown on CRC progression.
target gene	35100978	hsa-mir-503	Ovarian Neoplasms	Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis.
exosome	35100464	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	5p inhibits TGF-beta signaling-mediated fibroblast phenotypic transformation through NOX4, which is related to the excellent prognosis of HPV patients.
genetics_overexpression_promote	35100092	hsa-mir-135b	Colorectal Neoplasms	Inhibition of miR-135b-5p in EVs or overexpression of FOXO1 partially reversed the effect of EVs on promoting COAD-induced angiogenesis.
circRNA target	35100091	hsa-mir-532	Glioma	3p/c-MET/PI3K/AKT axis is a potential treatment target for glioma.
lncRNA target	35100082	hsa-mir-130b	Colorectal Neoplasms	MiR-130b-3p promotes the progression and tumorigenesis of CRC at least partially by targeting CHD9.Abbreviations: CRC: Colorectal cancer; miR-130b-3p: microRNA 130b-3p; CHD9: chromodomain helicase DNA binding protein 9; UTR: untranslated region; FIT: fecal immunochemical test; AAs: advanced adenomas.
lncRNA target	35100080	hsa-mir-15b	Osteosarcoma	In conclusion, this study suggests that TRPM2-AS could promote OS cell malignancy by sponging miR-15b-5p/PPM1D axis.
genetics_overexpression_promote	35100076	hsa-mir-149	Stomach Neoplasms	5p overexpression limited the growth of GC tumors in vivo.
circRNA target	35099761	hsa-mir-192	Myocardial Infarction	Circ-SWT1 ameliorates H(2)O(2)-induced apoptosis, oxidative stress and ER stress in cardiomyocytes via miR5p/SOD2 axis, suggesting the potential involvement of circ-SWT1 in AMI process.
genetics_overexpression_promote	35099637	hsa-mir-216b	Endometrial Neoplasms	Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development.
exosome	35099348	hsa-mir-141	Liver Cirrhosis	Transfer of circDIDO1 mediated by MSC-isolated exosomes suppressed HSC activation through the miR3p/PTEN/AKT pathway, gaining a new insight into the prevention of liver fibrosis in liver failure patients.
lncRNA target	35098480	hsa-mir-185	Ischemic Stroke	These findings demonstrated that ADAMTS9-AS2 promoted angiogenesis through regulating miR5p/IGFBP-2 axis, suggesting that ADAMTS9-AS2 may be a potential marker for the diagnosis and treatment of neurological diseases.
genetics_knock down_promote	35098439	hsa-mir-34b	Lymphoma, B-Cell	Knockdown of Foxp1 partially reversed the effects of miR-34b-5p inhibitor on DLBCL cell proliferation and apoptosis.
circRNA target	35098413	hsa-mir-214	Glioma	5p and inhibited miR
circRNA target	35098410	hsa-mir-361	Stomach Neoplasms	Our data showed that circ_0009910 might be a target for GC treatment, which could promote GC proliferation, metastasis, and glycolysis by the miR3p/SNRPA axis.
other	35098408	hsa-mir-520	Sepsis	GAS5 regulated inflammatory response by the miR3p/SOCS3 axis in LPS-induced macrophages, which furnished a novel therapeutic idea in clinical treatment of inflammation-induced sepsis.
other	35098407	hsa-mir-187	Opium Dependence	5p in opioid use disorder.
other	35098407	hsa-mir-155	Opium Dependence	5p in opioid use disorder.
genetics_overexpression_promote	35097136	hsa-mir-338	Prostatic Neoplasms	We found that most patients with prostate cancer overexpressed MMP-9; on the other hand, most of them underexpressed TIMP-1, RECK, and miR
lncRNA target	35097124	hsa-mir-548o	Breast Neoplasms	In this work, hsa_circ_0047604 expressed lower in breast cancer tissue and played the role of sponge of miR-548o. In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604-miR-548o-DACH1 axis, which might provide a therapeutic method for breast cancer.
transcription factor target	35096965	hsa-mir-155	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
transcription factor target	35096965	hsa-mir-182	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
transcription factor target	35096965	hsa-mir-183	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
transcription factor target	35096965	hsa-mir-96	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
transcription factor target	35096965	hsa-mir-200b	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
transcription factor target	35096965	hsa-mir-145	Neuralgia	Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP.
other	35096820	hsa-mir-122	Alcoholism	We found that hepatocyte enriched miR-192 and miR-122 levels were significantly decreased in alcohol treated hepatocytes whereas their levels were increased in the cell-free supernatant. The primary transcripts of miR-192 and miR-122 were reduced in alcohol treated hepatocytes, suggesting alcohol partially affects these miRNAs at the transcriptional level.
exosome	35096820	hsa-mir-192	Carcinoma, Hepatocellular	Inhibition of miR-192 in human hepatoma cells caused a significant increase in Rab27a, Rab35, syntaxin7 and syntaxin16 and a concurrent increase in exosome secretion, suggesting miR-192 regulates exosomes release in hepatocytes.
exosome	35096820	hsa-mir-192	Alcoholism	Collectively, our results reveal that alcohol modulates Rabs, VAMPs and syntaxins directly and partly via miR-192 to induce exosome machinery and release.
exosome	35096570	hsa-mir-101	Colorectal Neoplasms	HIPK3 Inhibition by Exosomal hsa-miR-101-3p Is Related to Metabolic Reprogramming in Colorectal Cancer.
genetics_knock down_suppress	35096564	hsa-mir-590	Urinary Bladder Neoplasms	Interestingly, we demonstrated that MED10 interacts with and is co-expressed with the microRNA, hsa-miR-590, and that CRISPR-mediated knockout of MED10 elicits the downregulation of miR-590 preferentially in metastatic UC cells, compared to their primary tumor peers. CONCLUSION: These data provide preclinical evidence that dysregulated MED10/MIR590 signaling drives onco-aggression, disease progression, and recurrence of bladder UC and that this oncogenic signal is therapeutically actionable for repressing the metastatic/recurrent phenotypes, enhancing therapy response, and shutting down stemness-driven disease progression and relapse in patients with BLCA/UC.
lncRNA target	35096421	hsa-mir-338	Diabetic Nephropathies	CONCLUSION: Circ-ADAM9 contributed to HG-induced ARPE9 cell injury by regulating miR3p/CARM1 axis, which provided effective targets for DR treatment.
other	35096344	hsa-let-7a	Diabetes Mellitus	Based on the obtained results in this study, the gene expression level of miRNA let-7a was lower in diabetic patients compared to healthy individuals in the group of control.
circulation_biomarker_prognosis_up	35096206	hsa-mir-125b	Acute Kidney Injury	Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b.
circulation_biomarker_prognosis_up	35096206	hsa-mir-125b	Heart Failure	Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b.
genetics_knock down_suppress	35096186	hsa-mir-146a	Osteoporosis	RESULTS: miR-146a-Exo administration presented the most potent effect on inhibition of pro-inflammatory cytokines production in high glucose-treated osteoclasts, restraint bone resorption, and restoration of the bone loss in streptozotocin-induced diabetic osteoporosis rats.
genetics_overexpression_promote	35096137	hsa-mir-124a	Aortic Aneurysm, Abdominal	Overexpressing miR-124a could effectively inhibit the proliferation and migration and promote the apoptosis of the AAA cells.
lncRNA target	35096064	hsa-mir-23a	Colonic Neoplasms	These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6.
exosome	35096062	hsa-mir-4792	Urinary Bladder Neoplasms	Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect.
lncRNA target	35096015	hsa-mir-654	Paranasal Sinus Neoplasms	3p as an antitumor gene targeted CREB1 to hamper malignant progression of SNSCC through miR
other	35095999	hsa-mir-143	Adenocarcinoma of Lung	PCAT19/miR3p plays a very important regulatory role in the occurrence and development of LUAD.
other	35095996	hsa-mir-93	Prostatic Neoplasms	Here we report the relevant role of IGF2 and miR5p as non-invasive biomarker for PC.
lncRNA target	35095879	hsa-mir-30	Ovarian Neoplasms	Additionally, according to public data, the LRRC75A-AS1-hsa-miR5p axis could inhibit the immune response of OC patients by upregulating CDK4/6, leading to a poor prognosis.
other	35095769	hsa-mir-1225	Adenocarcinoma of Lung	Finally, we constructed a ceRNA network that included two microRNAs (hsa-miR5p, hsa-miR-575) and five mRNAs (BARX2, BCL9, KCNK1, KIAA1324, TMEM182) specific to LINC00467 in LUAD.
other	35095769	hsa-mir-575	Adenocarcinoma of Lung	Finally, we constructed a ceRNA network that included two microRNAs (hsa-miR5p, hsa-miR-575) and five mRNAs (BARX2, BCL9, KCNK1, KIAA1324, TMEM182) specific to LINC00467 in LUAD.
other	35095494	hsa-mir-92a	Uterine Cervical Neoplasms	MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer.
other	35094988	hsa-mir-650	Carcinoma, Hepatocellular	RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases.
other	35094988	hsa-mir-512	Hcv Associated Disorders	5p were positively correlated in the cirrhotic group and in (f0-f4) group.
other	35094988	hsa-mir-512	Hepatitis C	5p were positively correlated in the cirrhotic group and in (f0-f4) group.
other	35094988	hsa-mir-512	Carcinoma, Hepatocellular	5p were positively correlated in the cirrhotic group and in (f0-f4) group.
other	35094988	hsa-mir-650	Hepatitis C	RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases.
other	35094988	hsa-mir-650	Hcv Associated Disorders	RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases.
circulation_biomarker_diagnosis_up	35094987	hsa-mir-370	Leukemia, Myeloid, Acute	CONCLUSION: miR-370 level in peripheral blood can serve as a potential non-invasive diagnostic biomarker and was significantly correlated with AML risk.
lncRNA target	35094653	hsa-mir-423	Breast Neoplasms	As a result, our work illustrated the tumor suppressor role of MBNL1-AS1 in breast cancer via upregulating miR
lncRNA target	35094651	hsa-mir-145	Substance Abuse, Intravenous	This study confirms that NR2F1-AS1 modulates IVDD progression by up-regulating the FOXO1 pathway through the sponge of miR
transcription factor target	35094634	hsa-mir-26	Stomach Neoplasms	Therefore, PFKFB3 down-regulated by miR5p inhibited the malignant phenotype of GC with hyperglycemia.
transcription factor target	35094593	hsa-mir-21	Precancerous Conditions	Presumptively, RUc may inhibit the angiogenesis of breast precancerous lesions by inhibiting Ras/Raf/MEK/ERK signaling pathway, thus relieving the inhibition of miR-21 on TIMP-3 and RECK, then down-regulating the secretion of angiogenic factors.
genetics_knock down_promote	35094303	hsa-mir-135b	Nasopharyngeal Carcinoma	Notably, knockdown of SIRT1 partially reversed the miR-135b-5p-induced change of EMT markers and metastasis of NPC cells.
genetics_knock down_promote	35094292	hsa-mir-103a	Uterine Cervical Neoplasms	Moreover, FBXW7 knockdown efficiently abrogated the influences of CC cells proliferation caused by miR-103a-3p inhibition.
lncRNA target	35094286	hsa-mir-124	Endometriosis	CONCLUSIONS: NEAT1 is significantly upregulated in EM, promoting malignant behavior in EM through targeting miR
genetics_overexpression_suppress	35094251	hsa-mir-25	Pancreatitis	Characteristic western blot, immunohistochemistry, and transmission electron microscopy results revealed that overexpression of miR
genetics_overexpression_promote	35093879	hsa-mir-378	Carcinoma, Renal Cell	Second, overexpression of miR-378 significantly suppressed the expression of POLR2A and RUNX2 in sRCC cells (p<0.01) and enhanced apoptosis (p<0.05).
transcription factor target	35093804	hsa-mir-190a	Liver Cirrhosis	Our study aims to investigate whether resveratrol (Res) can alleviate liver fibrosis through miR-190a-5p /HGF axis.
exosome	35093789	hsa-mir-342	Breast Neoplasms	Extracellular vesicles extracted from bone marrow mesenchymal stem cells carrying MicroRNA-342-3p inhibit the INHBA/IL13Rα2 axis to suppress the growth and metastasis of breast cancer.
lncRNA target	35093695	hsa-mir-34c	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our findings revealed a novel strategy to upregulate erastin-induced ferroptosis in OSCC through the miR-34c-3p/SLC7A11 axis, suggesting new insights into OSCC and a potentially useful therapeutic strategy for OSCC.
other	35093630	hsa-mir-107	Nervous System Diseases	OBJECTIVES: The aberrant expression of miR-107 has been confirmed in some neurological diseases, including ischemic stroke (IS).
other	35093630	hsa-mir-107	Infarction, Middle Cerebral Artery	RESULTS: Bioinformatics analysis revealed that miR-107 expression was elevated in rats with middle cerebral artery occlusion (MCAO), which was confirmed in OGD/R-treated PC12 cells.
other	35093630	hsa-mir-107	Ischemic Stroke	OBJECTIVES: The aberrant expression of miR-107 has been confirmed in some neurological diseases, including ischemic stroke (IS). RESULTS: Bioinformatics analysis revealed that miR-107 expression was elevated in rats with middle cerebral artery occlusion (MCAO), which was confirmed in OGD/R-treated PC12 cells.
genetics_knock down_promote	35093599	hsa-mir-578	Carcinoma, Hepatocellular	CONCLUSIONS: Circ-LARP1B knockdown restrained HCC tumorigenicity and enhanced radiosensitivity by regulating miR-578/IGF1R axis, providing a new target for the treatment of HCC.
genetics_overexpression_promote	35093591	hsa-mir-24-1	Liver Cirrhosis	CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis.
genetics_overexpression_promote	35093591	hsa-mir-27b	Liver Cirrhosis	CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis.
genetics_overexpression_promote	35093591	hsa-mir-23b	Liver Cirrhosis	CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis.
genetics_overexpression_promote	35093109	hsa-mir-671	Arthritis, Rheumatoid	5p overexpression restrained RA-FLS growth, invasion, migration and inflammation and promoted apoptosis, but STAT3 upregulation reversed the impacts.
genetics_knock down_promote	35092863	hsa-mir-3680	Osteoarthritis	Moreover, our in vivo study found that after knockdown of miR
transcription factor target	35092734	hsa-mir-376c	Reperfusion Injury, Renal Ischemia	Consequently, miR-376c-3p played an important role in renal IRI by promoting angiogenesis via targeting HIF-1alpha/VEGF pathway in male rats.
epigenetics	35092653	hsa-mir-4442	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-155	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-1273g	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-663	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-1273g	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-1304	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-4442	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-1304	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-3909	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-3909	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-663	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
epigenetics	35092653	hsa-mir-155	Developmental Disabilities	The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909.
circulation_biomarker_diagnosis_up	35092573	hsa-mir-18b	Polycystic Ovary Syndrome	Based on that, circulating miR-18b-5p levels can contribute to the progression of PCOS complications.
lncRNA target	35092560	hsa-mir-206	Myocardial Infarction	Therefore, targeting the HOTAIR/miR-206/FN1 axis may be a promising therapeutic method for MI.
other	35091894	hsa-mir-148a	Enterocolitis, Necrotizing	Collectively, our present study demonstrated that the miR-148a-3p/p53/SIRT1 axis has a considerable protective effect on NEC, and the agomir therapy provides a new treatment strategy for NEC.
genetics_overexpression_promote	35091706	hsa-mir-146b	Hirschsprung Disease	CONCLUSION: Circ-ITCH overexpression facilitated cell proliferation and migration in HSCR by regulating miR-146b-5p/RET/MAPK axis.
other	35091542	hsa-mir-146a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	A mechanism study indicated that USP6 regulation of IM resistance of CML cells was GLS1 dependent and regulated by miR-146a-5p.
lncRNA target	35091542	hsa-mir-146a	Leukemia	Dysregulation of miR-146a has been found in both adult and pediatric patients with acute leukemia.
genetics_overexpression_promote	35091535	hsa-mir-432	Cholangiocarcinoma	In contrast, overexpression of transcription factor E2F3 in CCA cells restored the CCA cellular activities that were inhibited by miR
lncRNA target	35091534	hsa-mir-124	Sepsis	3p improves myocardial injury in septic rats through targeted regulation of SP1 to mediate HDAC4/HIF-1alpha.
lncRNA target	35091534	hsa-mir-124	Cardiomyopathies	3p improves myocardial injury in septic rats through targeted regulation of SP1 to mediate HDAC4/HIF-1alpha.
genetics_overexpression_promote	35091088	hsa-mir-30	Colorectal Neoplasms	3p inhibitor or MYO6 overexpression attenuated the repressive impacts of circ_0011385 silencing on CRC process.
lncRNA target	35090549	hsa-mir-588	Diabetic Nephropathies	CONCLUSIONS: Altogether, our data suggest that ZFAS1 regulates the proliferation, oxidative stress, fibrosis, and inflammation of high glucose-induced diabetic nephropathy through the miR-588/ROCK1 axis.
lncRNA target	35090549	hsa-mir-588	Inflammation	CONCLUSIONS: Altogether, our data suggest that ZFAS1 regulates the proliferation, oxidative stress, fibrosis, and inflammation of high glucose-induced diabetic nephropathy through the miR-588/ROCK1 axis.
lncRNA target	35090460	hsa-mir-199b	Colorectal Neoplasms	CONCLUSIONS: Our findings suggest miR-199b-3p might serve as a promising therapeutic target against CTx resistant CRC, and provide scientific information for exploring novel strategies of improving the efficacy of CTx for CRC patients.
other	35090416	hsa-mir-4443	Adenocarcinoma of Lung	ENST00000630242 ceRNA network was identified in LUAD.
transcription factor target	35090386	hsa-mir-1	Intestinal Diseases	3p, and then blocking the Smad pathway to alleviate intestinal epithelial inflammation and oxidative stress injury caused by sepsis.
transcription factor target	35090386	hsa-mir-1	Sepsis	3p, and then blocking the Smad pathway to alleviate intestinal epithelial inflammation and oxidative stress injury caused by sepsis.
lncRNA target	35090377	hsa-mir-33a	Uterine Cervical Neoplasms	TP53TG1 accelerates the CC development via regulating miR-33a-5p to target FOXK2 with the involvement of PI3K/AKT/mTOR signaling pathway.
other	35090094	hsa-mir-218	Parkinson Disease	3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH.
other	35090094	hsa-mir-369	Parkinson Disease	3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH.
other	35090094	hsa-mir-539	Parkinson Disease	3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH.
lncRNA target	35089659	hsa-mir-4516	Carcinoma, Hepatocellular	In addition, the inhibition of miR-4516 partly reversed the inhibitory effect of LINC00520 silencing on HCC cell proliferation, migration and invasion. In conclusion, the inhibition of LINC00520 suppressed HCC cell proliferation, migration and invasion through mediating miR-4516/SOX5 axis.
genetics_overexpression_promote	35089495	hsa-mir-24	Cardiotoxicity	Overexpression of miR
lncRNA target	35089454	hsa-mir-433	Carcinoma, Non-Small-Cell Lung	CircZCCHC6 inhibited the progression of NSCLC cells partly by regulating the miR3p/LPCAT1 axis, implying a promising therapeutic target for the NSCLC treatment.
genetics_overexpression_suppress	35089329	hsa-mir-223	Fusarium   Solani-Induced Keratitis	3p attenuated inflammation in FK, reduced P62 expression, and increased the ratio of LC3-II/LC3-I, whereas the overexpression of miR
lncRNA target	35088877	hsa-mir-432	Colorectal Neoplasms	Thus, the LINC00649/miR4325p/HDGF pathway may be a promising target for CRC therapy.
lncRNA target	35088561	hsa-mir-195	Diabetes Mellitus, Type 2	OBJECTIVE: The aim of this study was to research the role and underlying mechanism of miR-195 involved in pancreatic beta-cell dedifferentiation induced by hyperlipemia in type 2 diabetes mellitus. CONCLUSIONS: MiR-195 promoted beta-cell dedifferentiation through negatively regulating Mfn2 expression and inhibiting the IRS-1/2/Pi3k/Akt pathway, providing a promising treatment for type 2 diabetes mellitus.
circulation_biomarker_diagnosis_ns	35088558	hsa-mir-2	Diabetes Mellitus, Type 2	5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose).
circulation_biomarker_diagnosis_ns	35088558	hsa-mir-1	Diabetes Mellitus, Type 2	5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose).
circulation_biomarker_diagnosis_ns	35088558	hsa-mir-21	Diabetes Mellitus, Type 2	5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose).
other	35088373	hsa-mir-7	Brain Diseases	Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke.
other	35088373	hsa-mir-7a	Stroke	We previously showed that treatment with miR-7 mimic prevents alpha-Syn induction and protects brain after stroke in rodents irrespective of age and sex. Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke.
other	35088373	hsa-mir-7	Stroke	We previously showed that treatment with miR-7 mimic prevents alpha-Syn induction and protects brain after stroke in rodents irrespective of age and sex. Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke.
other	35088373	hsa-mir-7a	Brain Diseases	Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke.
genetics_overexpression_promote	35088289	hsa-mir-455	Osteochondritis Dissecans	miR-455 overexpression also promoted SH-SY5Y cell viability and rescued them from OGD/R-induced apoptosis by binding to GPER1.
circulation_biomarker_diagnosis_up	35088229	hsa-mir-128	Constriction, Pathologic	3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients.
circulation_biomarker_diagnosis_up	35088229	hsa-mir-128	Coronary Disease	3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients.
lncRNA target	35088224	hsa-mir-153	Stomach Neoplasms	3p suppressed the growth and metastasis in GC cells by regulating SphK2, which might facilitate the search for novel biomarkers to treat GC.
exosome	35088190	hsa-mir-514a	Stomach Neoplasms	Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p.
lncRNA target	35087989	hsa-mir-34a	Parkinson Disease	We therefore suggest that 7-BIO inhibition of GSK3beta alleviates the MPP(+) induced neurotoxicity by regulating miR-29a-3p and miR-34a-5p expressions in Parkinson's disease model SH-SY5Y cells.
lncRNA target	35087989	hsa-mir-29a	Parkinson Disease	We therefore suggest that 7-BIO inhibition of GSK3beta alleviates the MPP(+) induced neurotoxicity by regulating miR-29a-3p and miR-34a-5p expressions in Parkinson's disease model SH-SY5Y cells.
lncRNA target	35087744	hsa-mir-195	Leukoplakia, Oral	Hsa_circ_0060927 was expected to be a molecular marker for the prevention and treatment of OLK carcinogenesis through the hsa_circ_0060927/miR
lncRNA target	35087744	hsa-mir-195	Squamous Cell Carcinoma of Head and Neck	Hsa_circ_0060927 was expected to be a molecular marker for the prevention and treatment of OLK carcinogenesis through the hsa_circ_0060927/miR
target gene	35087570	hsa-mir-557	Osteosarcoma	Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS.
other	35087281	hsa-mir-195	Diabetes Mellitus, Type 2	Moreover, the rs78312845 in miR-195 contributed to the level of FPG and HbA1C in nondiabetic group in the Han Chinese population.
genetics_GWAS	35087281	hsa-mir-144	Diabetes Mellitus, Type 2	METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway.
genetics_GWAS	35087281	hsa-mir-155	Diabetes Mellitus, Type 2	METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway.
genetics_GWAS	35087281	hsa-mir-222	Diabetes Mellitus, Type 2	METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway.
genetics_GWAS	35087281	hsa-mir-93	Diabetes Mellitus, Type 2	METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway.
genetics_GWAS	35087281	hsa-mir-126	Diabetes Mellitus, Type 2	METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway.
lncRNA target	35087196	hsa-mir-20b	Alzheimer Disease	Network analysis of protein-protein interactions and gene coexpression revealed other important potential miR-20b-5p targets among AD-related proteins/genes.
genetics_knock down_suppress	35086110	hsa-mir-133b	Carcinoma, Renal Cell	Importantly, miR-133b inhibition or MARCKS knockdown attenuated the anticancer effects of circ_0039569 knockdown on RCC growth. CONCLUSION: Diminished circ_0039569 restrains the growth and propagation of RCC cells via miR-133b/MARCKS axis, indicating an underlying effective therapeutic target for RCC patients.
lncRNA target	35085910	hsa-mir-520h	Polycystic Ovary Syndrome	Collectively, miR-520h hindered the proliferation and promoted the apoptosis of KGN cells via targeting IL6R to inhibit the development of PCOS, and these effects were possibly realized by JAK/STAT pathway.
lncRNA target	35085892	hsa-mir-4746	Colorectal Neoplasms	As revealed by function and mechanism experiments, targeting CCND1 mRNA 3'-UTR, mir-4746 can promote the degradation of CCND1 mRNA, thus reducing the protein level of CCND1, leading to cell G0-G1 phase arrest, and ultimately inhibiting the proliferation of CRC cells.
transcription factor target	35085590	hsa-mir-34a	Thyroid Cancer, Papillary	Results showed that crocin inhibited the viability and miR-34a-5p expression in papillary thyroid cancer (PTC) cells in a dose-dependent manner.
transcription factor target	35085578	hsa-mir-19b	Osteoporosis	The results show that miRNA-19b-3p plays an important role in the osteoporosis process after SCI through regulating EBF2 expression.
transcription factor target	35085578	hsa-mir-19b	Spinal Cord Injuries	The results show that miRNA-19b-3p plays an important role in the osteoporosis process after SCI through regulating EBF2 expression.
lncRNA target	35084673	hsa-mir-183	Thyroid Neoplasms	FOXO1 silencing reversed the inhibitory effect of miR
genetics_overexpression_promote	35084661	hsa-mir-192	Hypoxia-Ischemia, Brain	5p or overexpressed YAP1 in HIBD rats alleviated neurobehavioral impairment and neuronal damage, and decreased the expression levels of p-TAZ and VEGF expression in vivo.
lncRNA target	35084640	hsa-mir-206	Diabetic Nephropathies	The current study analyzes the role played by NEAT2/miR-206 upon cell death of renal tubular epithelial cells (RTECs), high glucose (HG)-induced inflammation and oxidative stress in diabetic nephropathy (DN). This miR-206 is predicted to be a latent target in the clinical treatment of DN.
exosome	35084622	hsa-mir-660	Breast Neoplasms	Interestingly, EV-loaded miR-660 from TAMs could be internalized by breast cancer cells.
other	35084609	hsa-mir-136	Myocardial Infarction	This study investigated how miR5p partially affected cardiomyocyte pyroptosis in rats with coronary microembolization (CME).
genetics_overexpression_promote	35084609	hsa-mir-136	Costello Syndrome	5p was under-expressed, whereas ATXN1L was overexpressed in rats with CME and in LPS-treated primary cardiomyocytes.
transcription factor target	35084609	hsa-mir-136	Heart Diseases	In conclusion, miR5p suppressed pyroptosis by upregulating PYDC1 via ATXN1L/CIC axis, thereby attenuating cardiac damage caused by CME.
circRNA target	35084579	hsa-mir-532	Angelman Syndrome	CONCLUSION: To sum up, our data showed that circCHMP5 regulated the miR5p/ROCK2 axis to accelerate ox-LDL-induced HUVECs injury, confirming that circCHMP5 might be a potential target for AS treatment.
other	35084460	hsa-mir-205	Diabetic Nephropathies	Here, we describe a novel feedback loop composed of HDAC2 and miR-205 that regulates ECM production in tubular epithelial cells in individuals with DKD. In conclusion, the HDAC2/SP1/miR-205 feedback loop may be crucial for the pathogenesis of DKD.
other	35084431	hsa-mir-299	Retinopathy of Prematurity	We used this model and human retinal endothelial cells (HRECs) under hypoxia to explore the relationship between taurine upregulated gene-1 (TUG1), vascular endothelial growth factor (VEGF), and miR3p on retinopathy of prematurity (ROP).
lncRNA target	35084431	hsa-mir-299	Retinal Neovascularization	CONCLUSIONS: TUG1 reduces the expression of VEGFA by competitively adsorbing miR3p and facilitates the regulation of retinal neovascularization, suggesting that it may serve as a new therapeutic target for retinal neovascular diseases.
transcription factor target	35084199	hsa-mir-146a	Colitis	In conclusion, our findings showed that hucMSC-Ex is effective in alleviating the deterioration of colitis via the miR-146a-mediated inhibition of SUMO1, which is crucial in this disease process.
genetics_knock down_promote	35083866	hsa-mir-493	Esophageal Neoplasms	Moreover, circFIG 4 knockdown inhibited EC tumorigenesis by targeting miR
transcription factor target	35083664	hsa-mir-876	Glioma	5p-targeted GNG12 contributes to the malignant development of glioma by increasing the PI3K/AKT signaling activity.
other	35083632	hsa-mir-92b	Polycystic Ovary Syndrome	We observed that circ-PRDM5 and COL1A2 were upregulated in PCO tissues and TGF-beta2-treated LECs, while miR-92b-3p was downregulated. In summary, TGF-beta2-induced circ-PRDM5 facilitated LEC migration, invasion, and EMT by adsorbing miR-92b-3p and increasing COL1A2 expression, offering new insights into the development of PCO.
transcription factor target	35083625	hsa-mir-26a	Inflammation	Collectively, these results suggest that miR-26a may function as a novel feedback negative regulator of the hyperinflammatory response and as a drug target for the progression of inflammation.
lncRNA target	35083615	hsa-let-7a	Pulmonary Fibrosis	5p contribute a pivotal role in pulmonary fibrosis and may be considered as possible therapeutic target for the clinical management of lung fibrosis.
lncRNA target	35083615	hsa-mir-503	Pulmonary Fibrosis	5p contribute a pivotal role in pulmonary fibrosis and may be considered as possible therapeutic target for the clinical management of lung fibrosis.
circulation_biomarker_diagnosis_up	35083607	hsa-mir-146b	Abortion, Habitual	Statistical analysis indicated miR-146b-5p expression was significantly up-regulated in URSA patients compared to normal pregnant women (P = 0.018). The circulating levels of miR-520 h and miR-146b-5p could be considered biomarkers for URSA diagnosis.
genetics_overexpression_promote	35083555	hsa-mir-22	Arthritis, Rheumatoid	3p or overexpression of CYR61 annulled the inhibitory effect of EZH2 silencing on RA-FLS proliferation, migration, and invasion.
other	35083300	hsa-mir-190a	Arrhythmias, Cardiac	This study aimed to investigate the molecular mechanism underlying the regulation of IL-2 and the sodium channel current of sodium voltage-gated channel beta subunit 3 (SCN3B) by miR-190a-5p in the progression of CAs. We, therefore, concluded that the miR-190a-5p/IL-2/SCN3B pathway could be involved in the pathogenesis of CAs and miR-190a-5p might acts as a potential protective factor in pathogenesis of CAs.
exosome	35083214	hsa-mir-140	Iris Diseases	SW-exo exerted a stronger therapeutic effect on H/R injury in H9c2 cells possibly via delivering exosomal miR3p, which might be a novel promising strategy for the myocardial IRI.
exosome	35083214	hsa-mir-140	Myocardial Ischemia	SW-exo exerted a stronger therapeutic effect on H/R injury in H9c2 cells possibly via delivering exosomal miR3p, which might be a novel promising strategy for the myocardial IRI.
transcription factor target	35083181	hsa-mir-766	Colonic Neoplasms	3p/TGFBI axis suppressed malignant behaviors and facilitated apoptosis of colon cancer cells.
other	35083143	hsa-mir-361	Uterine Cervical Neoplasms	SOX9, lncRNA ANXA2P2, and miR-361-3p form a regulatory loop, modulating DDP-resistant cervical cancer cell growth and response to DDP treatment.
transcription factor target	35083134	hsa-mir-136	Glioma	Hereby, we aim to explore the role of LINC00883 as a regulator of miR-136 and its target, NIMA-related kinase 1 (NEK1), thus, its involvement in the drug resistance of glioma cells.
other	35083026	hsa-mir-641	Breast Neoplasms	Moreover, miR-641 was negatively correlated with NR2F1-AS1 in BC tissues.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-223	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-221	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-139	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-377	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-200c	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-145	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
circulation_biomarker_diagnosis_ns	35083018	hsa-mir-424	Pancreatitis, Chronic	OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model.
lncRNA target	35083006	hsa-mir-21	Breast Neoplasms	CONCLUSION: It appears that aerobic exercise training reduces tumor size and ameliorates breast cancer by reducing miR-21 gene expression, suppressing the apoptosis process, and reducing angiogenesis.
genetics_overexpression_suppress	35082967	hsa-mir-126	Coronary Artery Disease	Overexpression of miR-126 significantly improved HUVEC cellular viabilities by downregulation of LRP6 protein expression, suggesting a potential therapeutic target for CAD patients.
other	35082915	hsa-mir-128	Asthma	CONCLUSION: lncRNA-NEAT1 sponges miR-128 to boost PDGF-BB-induced inflammatory reaction and phenotypic transformation of ASMCs to aggravate the occurrence and development of childhood bronchial asthma.
genetics_overexpression_promote	35082911	hsa-mir-335	Leiomyoma	Furthermore, overexpression of ARGLU1 partly restores the effects of miR
lncRNA target	35082831	hsa-mir-1343	Stomach Neoplasms	3p could be introduced as a valuable target for studies on the GC diagnosis using reliable biomarkers.
lncRNA target	35082786	hsa-mir-23	Acute Coronary Syndrome	5p inhibitor greatly promoted levels of PPP-related genes, reduced the macrophage phagocytosis of ACs, and increased inflammatory response during efferocytosis, suggesting that miR
other	35082517	hsa-mir-4636	Colorectal Neoplasms	RESULTS: Six clinicopathologic factors and expressions of six microRNAs (miR-614, miR-1197, miR-4770, miR-3136, miR-3173, and miR-4636) differed significantly between TDs and non-TDs CRC patients from the SEER and TCGA training sets.
other	35082517	hsa-mir-4770	Colorectal Neoplasms	RESULTS: Six clinicopathologic factors and expressions of six microRNAs (miR-614, miR-1197, miR-4770, miR-3136, miR-3173, and miR-4636) differed significantly between TDs and non-TDs CRC patients from the SEER and TCGA training sets.
other	35082509	hsa-mir-196a	Carcinoma, Squamous Cell, Cutaneous	More importantly, miR-196a was shown to have potential as a prognostic marker for CSCC.
genetics_knock down_promote	35082399	hsa-mir-28	Lymphoma, Large B-Cell, Diffuse	5p inhibition could reverse the effect of CDK12 knockdown on proliferation and apoptosis of DLBCL cells.
other	35082354	hsa-mir-145	Immune System Diseases	Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p.
other	35082354	hsa-mir-145	Chagas Disease	Thus, miR5p and miR-146b-5p deserve to be further investigated as biomarkers of parasite control and tools to identify therapeutic adjuvants to etiological treatment in Chagas disease.
other	35082354	hsa-mir-145	Chagas Cardiomyopathy	Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p.
other	35082354	hsa-mir-146b	Chagas Cardiomyopathy	Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p.
other	35082354	hsa-mir-146b	Chagas Disease	Thus, miR5p and miR-146b-5p deserve to be further investigated as biomarkers of parasite control and tools to identify therapeutic adjuvants to etiological treatment in Chagas disease.
other	35082354	hsa-mir-146b	Immune System Diseases	Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p.
circulation_biomarker_diagnosis_ns	35082326	hsa-let-7f	Amyotrophic Lateral Sclerosis	Receiver operating characteristic (ROC) analysis also highlighted the let-7f-5p and miR3p potential as robustness plasma biomarkers for diagnosis and potential therapeutic targets of sALS disease.
circulation_biomarker_diagnosis_ns	35082326	hsa-mir-338	Amyotrophic Lateral Sclerosis	Receiver operating characteristic (ROC) analysis also highlighted the let-7f-5p and miR3p potential as robustness plasma biomarkers for diagnosis and potential therapeutic targets of sALS disease.
lncRNA target	35082283	hsa-mir-29a	Stomach Neoplasms	LncRNA NR2F1-AS1 plays crucial roles in GC progression by modulating miR-29a-3p/VAMP7 axis, suggesting that NR2F1-AS1 may serve as a potential therapeutic target in GC.
lncRNA target	35081873	hsa-mir-125a	Carcinoma, Hepatocellular	MiR-125a-5p was downregulated in HCC cells and a target of CYTOR in regulating HCC progression.
lncRNA target	35081872	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Besides, PCAT6 could directly target miR-326 in gefitinib-resistant NSCLC cells and augment NSCLC resistance to gefitinib by serving as ceRNA of miR-326. Our investigation identified that PCAT6 enhanced gefitinib resistance of NSCLC via miR-326/IFNAR2 axis, which might offer a new therapeutic strategy against gefitinib resistance of NSCLC patients.
lncRNA target	35081869	hsa-mir-1245a	Carcinoma, Non-Small-Cell Lung	In conclusion, circ_0006677 regulated SATB2-mediated tumor-suppressive effect via acting as a miR-1245a sponge in NSCLC, providing a new mechanism for understanding the progression of NSCLC.
other	35081862	hsa-mir-217	Angelman Syndrome	All in all circ_0033596 aggravates ox-LDL-induced HUVEC apoptosis by regulating the miR5p/CLIC4 axis, by which circ_0033596 participates in the pathogenesis of AS.
lncRNA target	35081855	hsa-mir-656	Colorectal Neoplasms	3p could regulate cell proliferation and chemoresistance in the colorectal cancer that associate to downstream target with SGPP1.
other	35081125	hsa-mir-122	Carcinoma, Hepatocellular	In addition, the levels of tumor markers including alpha-fetoprotein, arginase-1, alpha-L-fucosidase, and ferritin were significantly increased, whereas the hepatic miR-122 level was significantly decreased in induced-HCC rats.
genetics_knock down_promote	35080988	hsa-mir-588	Nasopharyngeal Carcinoma	Inhibition of miR-588 could partially reverse the knockdown of SNHG8 in NC cells, and miR-588 targeted HMGA2. In conclusion, SNHG8 promotes proliferation, migration, and invasion of NC cells through miR-588/HMGA2 in NC as an oncogene.
other	35080329	hsa-mir-557	Carcinoma, Hepatocellular	The expression levels of circ_0040705 and SOX2 mRNA were markedly increased in HCC tissues, but miR-557 expression was down-regulated. Circ_0040705 facilitates HCC cell growth, migration, and invasion by down-modulating miR-557 expression and up-modulating SOX2 expression.
genetics_overexpression_suppress	35080031	hsa-mir-101	Carcinoma, Hepatocellular	3p inhibition or WEE1 overexpression could reverse the effect of Verbascoside on the viability and apoptosis of HCC cells.
circulation_biomarker_diagnosis_up	35079982	hsa-mir-155	Carotid Stenosis	Compared with those of the NC group, the expression of miR-155 in the miR-155 mimic group increased significantly (P < 0.05), the degree of carotid plaque formation increased, the plasma levels of TC and LDL also increased significantly (P < 0.05); the expression levels of NLRP3 inflammasome-related proteins, interleukin-1beta, interleukin-18, and MEK/ERK/NF-kappaB signaling pathway-related proteins were also significantly increased.
other	35079927	hsa-mir-661	Lymphoma, B-Cell	Transcriptional and translational levels of circPDE7B, microRNA (miR)-661, fibroblast growth factor 2 (FGF2), cleaved caspase3, B-cell lymphoma (bcl)-2, and bclassociated X protein (bax) were detected by real-time quantitative PCR and western blotting.
lncRNA target	35079927	hsa-mir-661	Keloid	Expression of circPDE7B was upregulated in human keloid tissues and HKFs, accompanied with miR-661 downregulation and FGF2 upregulation. In conclusion, circPDE7B might contribute to HKFs progression via functioning as ceRNA for miR-661, suggesting a novel circPDE7B/miR-661/FGF2 pathway underlying keloid formation and treatment.
genetics_knock down_promote	35079927	hsa-mir-661	Hyalinosis, Systemic	Deleting miR-661 and re-expressing FGF2 both abrogated the suppression of circPDE7B knockdown in HKFs progression.
genetics_overexpression_promote	35079913	hsa-mir-200c	Thyroid Cancer, Papillary	The effects of miR-200c-3p mimics on promoting the malignant behaviors of PTC cells were remarkably reversed by the overexpression of ATP2A2, as a downstream target of miR-200c-3p.
other	35079871	hsa-mir-613	Neurogenic Inflammation	Altogether, these results suggest that lncRNA MIAT functioned as a ceRNA for miR-613 to modulate NFAT5 expression in LPS-induced BV2 cells, which may contribute to a better understanding of the mechanism of neuroinflammatory diseases.
other	35079352	hsa-mir-221	Breast Neoplasms	CONCLUSION: miR-221 expression was higher in tamoxifen-resistant BC cases.
circulation_biomarker_diagnosis_up	35079347	hsa-mir-29b	Asthma	RESULTS: MiR-29b levels were decreased in the peripheral blood mononuclear cells from children with asthma.
genetics_GWAS	35079080	hsa-mir-34b	Squamous Cell Carcinoma of Head and Neck	Pre-miR-34b/c polymorphism was not associated with oral cancer risk.
other	35079043	hsa-mir-144	Parkinson Disease	These promising results ask for further research to unveil the functional details of the involvement of hsa-mir144-3p in Parkinson's Disease.
other	35078502	hsa-mir-29c	Carcinoma, Ductal, Breast	Furthermore, we identified that miR-29c negatively regulated a stemness promoting gene, ID2, and diminished self-renewal ability of DCIS cells. CONCLUSION: Our findings revealed a critical role of the IPW-miR-29c-ID2 axis in DCIS formation and suggested potential clinical use of toyocamycin for the treatment of DCIS.
genetics_overexpression_promote	35078498	hsa-mir-497	Ovarian Neoplasms	Studies have demonstrated that overactivation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is involved in tumor chemoresistance and that overexpression of microRNA-497 (miR497) may overcome OC chemotherapy resistance by inhibiting the mTOR pathway. RESULTS: Herein, whether the combined application of miR497 and TP could further overcome OC chemoresistance by synergically suppressing the mTOR signaling pathway was investigated.
genetics_overexpression_promote	35078194	hsa-mir-155	Carcinoma, Renal Cell	RESULTS: Experimental data suggested that overexpression or silencing of microRNA
lncRNA target	35077859	hsa-mir-486	Myocardial Reperfusion Injury	In conclusion, miR-486 is protective against cardiac I/R injury and myocardial apoptosis through targeting of PTEN and FoxO1 and activation of the AKT/mTOR pathway, and mediates the beneficial effect of exercise for myocardial protection. Increasing miR-486 might be a promising therapeutic strategy for myocardial protection.
other	35077391	hsa-mir-98	pancreatic adenocarcinoma	Moreover, CASKIN2, TLE2, USP20, SPRN, ARSG, MIR106B, and MIR98 might be associated with low-risk patients with PAAD.
other	35077391	hsa-mir-106b	pancreatic adenocarcinoma	Moreover, CASKIN2, TLE2, USP20, SPRN, ARSG, MIR106B, and MIR98 might be associated with low-risk patients with PAAD.
genetics_knock down_suppress	35076987	hsa-mir-877	Carcinoma, Non-Small-Cell Lung	CONCLUSION: CircPRH1-PRR4 knockdown impeded NSCLC cell malignancy by the miR
lncRNA target	35076913	hsa-mir-4500	Glioma	CONCLUSION: Down-regulating TTTY15 targeting miR-4500 can inhibit the proliferation, migration, invasion and induce apoptosis of the A172 glioma cells.
target gene	35076912	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	Silencing circ-SFMBT2 can suppress the proliferation, clone formation, invasion ability and induce apoptosis of NSCLC cells by regulating the miR-7-5p/ADAM10 axis.
other	35076836	hsa-mir-623	Carcinoma, Non-Small-Cell Lung	RT-qPCR was carried out to detect CTBP1-AS2 and miR-623 expression in NSCLC cells and tissues. Moreover, the miR-623 level was lower in NSCLC specimens than in paired non-tumor specimens, and CTBP1-AS2 expression was negatively correlated with miR-623 expression in NSCLC samples.
other	35076819	hsa-mir-885	Alzheimer Disease	These experimental data demonstrated that circ_0003611 enhanced the Abeta-induced neuronal cell injury in AD by serving as the miR5p sponge to regulate the level of KREMEN1.
circRNA target	35076816	hsa-mir-107	Inflammation	Circ-LTBP1 was found to enhance DOX-induced effects on proliferation inhibition, inflammation, apoptosis, and oxidative stress in AC16 cells through competitively sponging miR-107 and elevating ADCY1.
other	35076814	hsa-mir-1249	Adenocarcinoma of Lung	Our findings demonstrate that the circ_0010235/miR3p/HOXA13 axis is implicated in the pathogenesis of LUAD.
circulation_biomarker_diagnosis_ns	35076541	hsa-mir-27a	Kidney Failure, Chronic	We first determined the association between the vascular injury markers and specific heart conditions and observed that ESKD patients with coronary heart disease have significantly higher levels of circulating ADMA and miR-27a.
exosome	35076227	hsa-mir-129	Diabetes Mellitus, Type 1	miR-129 was shown as a candidate related to both resveratrol and wound healing in T1DM. Resveratrol exerts promotive role in wound healing in T1DM through downregulation of TRAF6 via MSC-EV-carried miR-129, suggesting a regulatory network involved in the wound healing process in T1DM.
circulation_biomarker_diagnosis_up	35076188	hsa-mir-21	Diabetes Mellitus, Type 2	miR-21 expression was positively associated with glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and triglyceride (TG) and might have diagnostic value for T2DM and pre-T2DM.
circulation_biomarker_diagnosis_ns	35076182	hsa-mir-205	Lung Neoplasms	The area under the ROC curve of serum miR
lncRNA target	35075728	hsa-mir-215	Inflammation	Our findings provide a rationale for targeting miR-215 as a therapeutic intervention for inflammatory conditions in the small intestine.
transcription factor target	35075615	hsa-mir-375	Infertility	It provides evidence that miR-375 is a negative regulator of decidualization and could serve as a potential target for combating infertility.
other	35075615	hsa-mir-375	Endometriosis	Previous studies have revealed altered expression of miR-375 in the endometrium of patients with recurrent implantation failure and the ectopic stromal cells of patients with endometriosis.
genetics_overexpression_promote	35075610	hsa-mir-200b	Endometriosis	We found an upregulation of the miR-200b-3p in endometriosis MenSCs (P = 0.0207), with a 7.93-fold change (ratio of geometric means) compared to control. Overexpression of miR-200b has been associated with increased cell proliferation, stemness, and accentuated mesenchymal-epithelial transition process in eutopic endometrium of endometriosis.
genetics_overexpression_promote	35075603	hsa-mir-1	Esophageal Squamous Cell Carcinoma	In ESCC cells, NRON overexpression decreased miR-31 expression, while miR-31 failed to alter NRON expression.
lncRNA target	35075548	hsa-mir-20	Depression	3p to target CRHR1.
lncRNA target	35075501	hsa-mir-185	Schizophrenia	Nonetheless, the miR-185 expression profile and its corresponding target genes in animal models and patients with 22q11.2 deletion syndrome (22q11.2DS) imply that more study is required about miR-185 and its corresponding downstream pathways within idiopathic SCZ. Our findings suggest that gene expression alterations mediated by miR-185 may play a role in the pathogenesis of idiopathic and 22q11.2DS SCZ.
other	35075375	hsa-mir-133a	Prostatic Neoplasms	The most interesting 8 prognostic biomarkers for prostate cancer included lncRNA LINC01082, miRNA hsa-miR-133a-3p, and genes TTLL12, PTGDS, GAS6, CYP27A1, PKP3, and ZG16B.
target gene	35075362	hsa-mir-223	Uterine Cervical Neoplasms	HDAC10 Inhibits Cervical Cancer Progression through Downregulating the HDAC10-microRNA-223-EPB41L3 Axis.
circulation_biomarker_diagnosis_up	35075166	hsa-mir-363	Pre-Eclampsia	Serum miR-17, miR-363 and MALAT-1 could have utility as new biomarkers of PE diagnosis.
other	35075166	hsa-mir-17	Pre-Eclampsia	In PE, miR-17 and MALAT-1 were significantly correlated with gestational age (r = - 0.328 and r = 0.322, respectively) and albuminuria (r = 0.312, and r = - 0.35, respectively).
exosome	35075150	hsa-mir-181a-2	Parkinson Disease	Collectively, our findings revealed that MSC-derived EV-loaded miR-181a
other	35075117	hsa-mir-4693	Colorectal Neoplasms	miR5p was significantly downregulated in CRC tumor tissues and bound to the 3' untranslated region (3'UTR) of TRIP13, downregulating TRIP13 expression.
circulation_biomarker_diagnosis_ns	35075115	hsa-mir-582	Prostatic Neoplasms	Mechanistically, DLEU2 promoted serum and glucocorticoid-induced protein kinase 1 (SGK1) expression by acting as an miR
other	35074681	hsa-mir-21	Lung Neoplasms	Paper-based electrodes modified with molybdenum disulfide (MoS(2)) in the form of bulk crystals or exfoliated nanosheets were developed and used as a biosensing platform for the impedimetric detection of miRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer.
other	35074681	hsa-mir-155	Lung Neoplasms	Paper-based electrodes modified with molybdenum disulfide (MoS(2)) in the form of bulk crystals or exfoliated nanosheets were developed and used as a biosensing platform for the impedimetric detection of miRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer.
genetics_overexpression_promote	35074616	hsa-mir-197	Multiple Myeloma	Overexpression of miR
circulation_biomarker_diagnosis_ns	35074547	hsa-mir-140	Osteoarthritis	METHOD: Primary (passage 1/2) human OA chondrocytes were isolated from arthroplasty samples (six donors) and transfected with ribonuclear protein complexes or plasmids using single guide RNAs (sgRNAs) targeting miR-140, in combination with Cas9 endonuclease.
circRNA target	35074490	hsa-mir-599	Absent corpus callosum cataract immunodeficiency	CONCLUSION: CircANKRD36 can inhibit the expression of miR-599 and the activation of TGF-beta signaling pathway, thus inhibiting the expression of differentiation-related factors of VIC osteogenesis and the formation of calcified nodules.
other	35074490	hsa-mir-599	autosomal recessive congenital bilateral absence of vas deferens	TGF-beta axis can be a new theoretical basis for treating CAVD.
exosome	35073936	hsa-mir-494	Carcinoma, Hepatocellular	3p expression level in exosomes derived from HCC cells without affecting total cellular miR
other	35073841	hsa-mir-133b	Esophageal Neoplasms	Both CREB1 and miR-133b was involved in the beta3GNT2-mediated ESCA progression.
genetics_overexpression_suppress	35073820	hsa-mir-26a	Nasopharyngeal Carcinoma	The overexpression of miR-26a-5p inhibited the viability, proliferation, migration, and invasion of NPC cells.
other	35073575	hsa-mir-222	Diabetes Mellitus, Type 2	3p: HR 1.97, P = 9.10E-03) in the highest versus lowest tertile of expression.
other	35073542	hsa-mir-34b	Hypoxia-Ischemia, Brain	5p at the time of admission to the NICU.
other	35073542	hsa-mir-338	Hypoxia-Ischemia, Brain	5p at the time of admission to the NICU.
other	35073542	hsa-mir-142	Hypoxia-Ischemia, Brain	5p at the time of admission to the NICU.
other	35073542	hsa-mir-497	Hypoxia-Ischemia, Brain	5p at the time of admission to the NICU.
other	35073542	hsa-mir-145	Hypoxia-Ischemia, Brain	At 48 h, infants suffering from moderate/severe HIE with a poor long-term neurodevelopmental outcome showed a significant increase in hsa-mir5p.
other	35073542	hsa-mir-98	Hypoxia-Ischemia, Brain	5p at the time of admission to the NICU.
lncRNA target	35072892	hsa-mir-153	Colorectal Neoplasms	Finally, ARCR suppressed the polarization of M2 macrophages to inhibit the tumor growth and tumor metastasis in CRC by mediating the Sp1/ZFAS1/miR
lncRNA target	35072651	hsa-mir-203a	Nasopharyngeal Carcinoma	Furthermore, miR-203a-3p regulated the PI3K/AKT signal pathway by downregulating the expression of VEGF-C, thereby inhibiting the proliferation, migration, invasion, vasculogenic mimicry, epithelial-mesenchymal transition, and other malignant biological characteristics of nasopharyngeal carcinoma cells.
genetics_overexpression_promote	35072529	hsa-mir-582	Nasopharyngeal Carcinoma	In the final rescue assays, we observed that the effect of HOXA10-AS depletion on NPC cell growth could be fully reversed by RAB31 overexpression or miR
other	35072021	hsa-mir-19b	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
other	35072021	hsa-mir-320c	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
other	35072021	hsa-mir-320d	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
other	35072021	hsa-mir-20b	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
circulation_biomarker_diagnosis_ns	35072021	hsa-mir-193a	Non-alcoholic Fatty Liver Disease	CONCLUSIONS: Serum miR-193a-5p levels correlate strongly with NAFLD activity grade and fibrosis stage.
other	35072021	hsa-mir-378e	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
other	35072021	hsa-mir-320e	Non-alcoholic Fatty Liver Disease	Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity.
lncRNA target	35071928	hsa-mir-141	Prostatic Neoplasms	Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis.
lncRNA target	35071928	hsa-mir-21	Prostatic Neoplasms	Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis.
lncRNA target	35071928	hsa-let-7c	Prostatic Neoplasms	Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis.
lncRNA target	35071928	hsa-mir-200b	Prostatic Neoplasms	Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis.
lncRNA target	35071928	hsa-let-7a	Prostatic Neoplasms	Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis.
lncRNA target	35071776	hsa-mir-199a	Leiomyoma	These findings broaden the current findings on the function of miR-199a-5p into the ULM pathogenesis, and miR-199a-5p may serve as a prognosis and therapeutic target for the ULM and its related diseases.
genetics_overexpression_promote	35071744	hsa-mir-23a-2	Carcinoma, Non-Small-Cell Lung	In addition, in vitro and in vivo experiments show that overexpression or inhibition of all miRNAs in the miR-23a/27a/24-2 cluster significantly stimulated or inhibited NSCLC cell stemness, tumorigenicity and metastasis.
circulation_biomarker_diagnosis_up	35071600	hsa-mir-126	Hypertension	We evaluated the effects of MitoQ supplementation and endurance training (ET), alone and in combination, on functional indices of the heart and serum levels of miR-126, miR-27a, antioxidants, and NO, in patients with HTN.
circulation_biomarker_diagnosis_up	35071600	hsa-mir-27a	Hypertension	We evaluated the effects of MitoQ supplementation and endurance training (ET), alone and in combination, on functional indices of the heart and serum levels of miR-126, miR-27a, antioxidants, and NO, in patients with HTN.
genetics_knock down_promote	35071487	hsa-mir-629	Carcinoma, Non-Small-Cell Lung	5p inhibition or TXNIP overexpression.
circulation_biomarker_diagnosis_ns	35071475	hsa-mir-223	Cerebral Small Vessel Diseases	CONCLUSIONS: The expression of plasma exosomal miRNA
genetics_overexpression_promote	35071464	hsa-mir-96	Ovarian Neoplasms	GAS5 overexpression could significantly reduce OC cell proliferation and invasion ability via suppression of miR
target gene	35071456	hsa-mir-7641	Cerebral Small Vessel Diseases	LncRNA MALAT1 induced by hyperglycemia promotes microvascular endothelial cell apoptosis through activation of the miR-7641/TPR axis to exacerbate neurologic damage caused by cerebral small vessel disease.
therapeutic target	35071455	hsa-let-7a	Breast Neoplasms	5-FU@DHA-UIO-66-NH(2) potentiates chemotherapy sensitivity of breast cancer cells through a microRNA let-7a-dependent mechanism.
other	35071451	hsa-mir-611	Adenocarcinoma of Lung	The expression of miR-3611, which is regulated by hsa_circ_0031968, was found to significantly affect the survival and prognosis of patients with LUAD (P</=0.05). CONCLUSIONS: The ceRNA regulatory network hsa_circ_0031968/miR-3611/GCG was successfully constructed and this provided novel insights into the identification of biomarkers and the pathogenesis of LUAD.
transcription factor target	35071422	hsa-mir-214	Coronary Artery Disease	CONCLUSIONS: Our data suggested that the PDGF/miR-214/Pim-1 axis could be a potential target for coronary atherosclerotic heart disease.
target gene	35070952	hsa-mir-155	Squamous Cell Carcinoma of Head and Neck	MicroRNA-155-5p Contributes to 5-Fluorouracil Resistance Through Down-Regulating TP53INP1 in Oral Squamous Cell Carcinoma.
other	35070947	hsa-mir-195	Breast Neoplasms	5p/FASN/AMPK/mTOR pathway.
target gene	35070838	hsa-mir-143	Neuroblastoma	CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis.
genetics_overexpression_promote	35070756	hsa-mir-4306	Adenocarcinoma of Lung	The effects of miR-4306 overexpression on cancer cell viability and invasive abilities were also partially attenuated by IGF2R overexpression in lung adenocarcinoma cells with irradiation.
lncRNA target	35070430	hsa-mir-144	Carcinoma, Hepatocellular	EIF2S2 target networks in HCC were identified in kinase, miRNA, and transcription factor networks, including the mitogen-activated protein kinase 1 (MAPK1), miRNAs (Mir-144), and transcription factors (GGAANCGGAANY_UNKNOWN) using GeneMANIA.
other	35070428	hsa-mir-3960	Carcinoma, Hepatocellular	Transfection of miR-634, miR-638, and miR-3960 reversed the enhanced invasion and proliferation in HCC cells with a high level of NEAT1 expression.
other	35070246	hsa-mir-506	Breast Neoplasms	CONCLUSION: miR-451 and miR-506 could be used as biomarker for the diagnosis and prognosis of breast cancer.
other	35070246	hsa-mir-451	Breast Neoplasms	CONCLUSION: miR-451 and miR-506 could be used as biomarker for the diagnosis and prognosis of breast cancer.
genetics_overexpression_promote	35070212	hsa-mir-140	Leukemia, Myeloid, Acute	DISCUSSION: Reduced expression levels of DNAJC3-AS1 were observed after overexpression of miR-140 in AML cells.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-146a	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-29a	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-126	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-195	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-15a	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
circulation_biomarker_diagnosis_ns	35070159	hsa-mir-125b	Depressive Disorder, Major	METHOD: The basal levels (T0) of seven candidate miRNAs (miR-15a/miR-29a/miR-125b/miR-126/miR-146a/miR-195 were measured in the whole blood of 41 TRD patients.
target gene	35070046	hsa-mir-125b	Stomach Neoplasms	Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis.
circulation_biomarker_diagnosis_up	35070014	hsa-mir-519d	Carcinoma, Hepatocellular	AIM: To determine whether serum microRNA, hsa-miR-519d, is linked to SQSTM1 gene and whether they could be used as diagnostic biomarkers for early-stage HCC.
lncRNA target	35069980	hsa-mir-4735	Uterine Cervical Neoplasms	Using bioinformatics analysis, RNA pull-down, ChIP, and luciferase reporter assays, we verified the molecular mechanisms of lncRNA SNHG15 in CC progression and found that lncRNA SNHG15 expression in CC cells is transcriptionally regulated by SOX12; moreover, lncRNA SNHG15 promotes CC progression via the miR3p/HIF1a axis.
genetics_overexpression_promote	35069901	hsa-mir-1285	Uterine Cervical Neoplasms	Conclusion: The overexpressed circRNA_400029 promoted CC proliferation, migration and invasion while deduced apoptosis by sponging miR
target gene	35069876	hsa-mir-15a	Prostatic Neoplasms	MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression.
genetics_overexpression_promote	35069846	hsa-mir-195	Hemangioma	SKI overexpression alleviated the miR
lncRNA target	35069821	hsa-mir-340	Pancreatic Beta-Cell Dysfunction	Thus, the therapeutic application of miR5p may be a useful strategy in AP via upregulation of HMGB1 and subsequent promotion of inflammation and apoptosis.
lncRNA target	35069793	hsa-mir-370	Colorectal Neoplasms	The expression of circCCDC66 in CRC tissues was positively correlated with MDM4 and negatively correlated with miR-370. circCCDC66 upregulates MDM4 through competitive binding to miR-370, thereby enhancing the metastatic ability of CRC cells and promoting the development of CRC.
lncRNA target	35069784	hsa-mir-641	Breast Neoplasms	CONCLUSION: miR-641 functioned as a tumor suppressor through the PI3K/AKT signaling pathway via targeting NUCKS1 in breast cancer.
other	35069734	hsa-mir-451a	Pancreatic Carcinoma	In our study, qRT-PCR was conducted for examining microRNA (miR)-451a and myocyte enhancer factor 2D (MEF2D) expressions in PANC-1 cells. In a word, our results revealed that the acidic microenvironment regulated PC progression by affecting the miR-451a/MEF2D axis, indicating a novel avenue for the future treatment of PC.
other	35069696	hsa-mir-29c	Carcinoma, Non-Small-Cell Lung	The circACC1/miR-29c-3p/MCL-1 axis is important in NSCLS proliferation.
transcription factor target	35069685	hsa-mir-27a	Osteoporosis	Hence, unearthing the downstream target gene of miR-27a-3p is of great significance to understand the molecular mechanism of osteoporosis. Conclusion: The miR-27a-3p/GLP1R regulatory axis in pre-osteoblasts contributes to understanding the molecular mechanism of osteoporosis.
lncRNA target	35069550	hsa-mir-18a	Myositis	Therefore, miR-18a-3p and its target protein HuR may be responsible for modulating the myogenic process in IMNM and can thus be therapeutic targets for the same.
exosome	35069547	hsa-mir-25	Periodontitis	Taken together, these data suggest that exosomal miR
other	35069510	hsa-let-7a	Herpesviridae Infections	Collectively, these findings indicate that RTA and LANA compete for let-7a/RBPJ signal to control the KSHV replication.
exosome	35068871	hsa-mir-135a	Carcinoma, Hepatocellular	Functional assays showed that exosomal miR-135a-5p induced apoptosis protection, cell proliferation, and chemotherapy resistance in HCC.
exosome	35068445	hsa-mir-143	Neuroblastoma	In conclusion, these findings demonstrate that exosome-delivered circDLGAP4 promotes the glycolysis, proliferation, and invasion of sensitive NB cells by regulating miR-143 and HK2, providing a novel link between drug resistance and circDLGAP4/miR-143/HK2 axis in drug-resistant NB.
transcription factor target	35068373	hsa-mir-140	Multiple Myeloma	3p could act as a new target for treating MM.
genetics_overexpression_promote	35068341	hsa-mir-214	Colorectal Neoplasms	Finally, overexpressed heparin-binding growth factor (HDGF) overturned the effects on viability, metastasis, and apoptosis of CRC cells induced by SPINT1-AS1 depletion or miR-214 upregulation.
other	35068339	hsa-mir-92a	Myocardial Reperfusion Injury	circRbms1 participated in myocardial I/R injury by regulating the miR-92a/BCL2L11 signaling pathway, which may provide a new strategy for the treatment of AMI.
genetics_overexpression_promote	35068331	hsa-mir-223	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Moreover, miR-223 inhibitor or FLT3 overexpression partially annulled the effect of 2-ME AA on CML cells.
lncRNA target	35068326	hsa-mir-888	Carcinoma, Non-Small-Cell Lung	All in all, Circ-CUL2 is anti-NSCLC via miR
lncRNA target	35068324	hsa-mir-21	Keloid	Silencing circPTPN12 targeted miR
genetics_overexpression_promote	35068192	hsa-mir-16	Insulin Resistance	In in vitro experiments, although inhibition of miR-16 induced impaired insulin signaling (P = 0.002) and glucose uptake (P = 0.014), overexpression of miR-16 did not attenuate lipid overload-induced insulin resistance using the diacylglycerol analog 1-oleoyl
lncRNA target	35068192	hsa-mir-16	Diabetes Mellitus, Type 2	Lower miR-16 content is consistent across different models of T2DM; however, the role of miR-16 in muscle metabolic health is still elusive. Our findings suggest distinct sex differences in muscle adaptation in response to miR-16 deletion and miR-16 may serve as a key regulator for metabolic dysregulation in T2DM.NEW & NOTEWORTHY We set to investigate the role of miR-16 in skeletal muscle during diet-induced insulin resistance.
lncRNA target	35068192	hsa-mir-16	Metabolic Diseases	Our findings suggest distinct sex differences in muscle adaptation in response to miR-16 deletion and miR-16 may serve as a key regulator for metabolic dysregulation in T2DM.NEW & NOTEWORTHY We set to investigate the role of miR-16 in skeletal muscle during diet-induced insulin resistance. Interestingly, miR-16 deletion leads to insulin resistance in males and exacerbated glucose intolerance in females, suggesting different mechanisms of metabolic dysregulation with a lack of miR-16 between sexes.
genetics_knock down_promote	35068163	hsa-mir-182	Urinary Bladder Neoplasms	Gain- and loss-of-function studies showed that the overexpression of miR
transcription factor target	35067807	hsa-mir-361	Reperfusion Injury, Cerebral Ischemia	3p could improve ischemia brain injury by targeting NACC1 through the PINK1/Parkin pathway.
transcription factor target	35067796	hsa-mir-204	Brain Ischemia	5p and inhibiting BRD4.
circulation_biomarker_diagnosis_ns	35067470	hsa-mir-1	Atrial Fibrillation	CONCLUSIONS: In this cohort, plasma levels of miR
genetics_knock down_suppress	35067172	hsa-mir-26a	Ischemic Stroke	circTLK1 and PTEN were highly expressed while miR-26a-5p was under-expressed in IS models. In conclusion, circTLK1 knockdown relieved IS via the miR-26a-5p/PTEN/IGF-1 R/GLUT1 axis.
other	35067169	hsa-mir-19b	Choroidal Melanoma	The results showed that the levels of TINCR and ERK-2 were markedly increased in DDP-resistant CM tissues and cells, while miR-19b-3p level was significantly reduced. Further experiments revealed that TINCR enhanced DDP resistance in CM cells by regulating the miR-19b-3p/ERK-2/NF-kb axis.
genetics_overexpression_promote	35067167	hsa-mir-124	Hypoxia-Ischemia, Brain	3p-overexpressing BMSCs-Exo.
lncRNA target	35067156	hsa-mir-34a	Lung Neoplasms	CONCLUSIONS: XIST/miR-34a-5p/PDL1 axis was involved in the malignant biological behavior of lung cancer cells and the immune function of CD8(+) T cells.
circRNA target	35066780	hsa-mir-424	Carcinoma, Hepatocellular	5p and upregulates ATG14, thus promoting HCC cell proliferation and autophagy.
epigenetics	35066776	hsa-mir-497	Thyroid Neoplasms	This study suggested that hypermethylation of miR
circulation_biomarker_diagnosis_up	35066768	hsa-mir-192	Pulmonary Fibrosis	METHODS: We investigated the plasma levels of miR-21, miR-590, miR-192, and miR-215 in IPF (n = 88) and healthy control (n = 20) groups in this study. There was no significant difference between the miR-192 and miR-215 expression levels of the IPF and control group.
circulation_biomarker_diagnosis_up	35066768	hsa-mir-215	Pulmonary Fibrosis	METHODS: We investigated the plasma levels of miR-21, miR-590, miR-192, and miR-215 in IPF (n = 88) and healthy control (n = 20) groups in this study. There was no significant difference between the miR-192 and miR-215 expression levels of the IPF and control group.
circRNA target	35066758	hsa-mir-140	Uterine Cervical Neoplasms	3p to suppress the expression of PDZK1, providing a promising therapeutic target.
transcription factor target	35066738	hsa-mir-143	Myocardial Reperfusion Injury	3p expression to inhibit PRKCE transcription and further aggravating cardiomyocyte pyroptosis and MI/R injury.
genetics_overexpression_suppress	35066566	hsa-mir-185	Myocardial Reperfusion Injury	Moreover, overexpression of CDK6 significantly inhibited the effects of miR
lncRNA target	35066501	hsa-mir-138	Pneumonia	CONCLUSION: Anthocyanins inhibited the NF-kappaB pathway by regulating the miR
lncRNA target	35066501	hsa-mir-138	Asthma	CONCLUSION: Anthocyanins inhibited the NF-kappaB pathway by regulating the miR
lncRNA target	35066433	hsa-mir-423	Colorectal Neoplasms	The effect of OGFRP1 suppression in CRC cells could be counteracted by miR
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-1	Diabetes Complications	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-19b-1	Diabetes Mellitus, Type 2	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-19b-1	Diabetes Complications	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-203a	Diabetes Mellitus, Type 2	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-203a	Diabetes Complications	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_ns	35066213	hsa-mir-1	Diabetes Mellitus, Type 2	We found that 3 serum miRNAs were significantly associated with incident diabetic fragility fracture: while low expression of miR-19b
circulation_biomarker_diagnosis_up	35066205	hsa-mir-29c	Venous Thrombosis	METHODS: QRT-PCR and western blot were performed to detect the expression of hsa_circ_0001020, miR-29c-3p, and MDM2 expression in human peripheral blood of DVT and endothelial progenitor cells (EPCs), respectively.
other	35066091	hsa-mir-497	Medulloblastoma	CONCLUSIONS: miR-497/ARHGDIA axis participates in the in vitro migration and invasion of human medulloblastoma cell lines.
other	35065761	hsa-let-7b	Radiation Injuries	The computational analysis identified hsa-miR-762, hsa-let-7c-5p, and has-let-7b-5p regulate the highest number of genes being associated with cognitive, mental, and motor delay.
other	35065761	hsa-let-7c	Radiation Injuries	The computational analysis identified hsa-miR-762, hsa-let-7c-5p, and has-let-7b-5p regulate the highest number of genes being associated with cognitive, mental, and motor delay.
other	35065761	hsa-mir-762	Radiation Injuries	The computational analysis identified hsa-miR-762, hsa-let-7c-5p, and has-let-7b-5p regulate the highest number of genes being associated with cognitive, mental, and motor delay.
other	35064892	hsa-mir-1226	Breast Neoplasms	lncRNA PPP1R26-AS1 could act as ceRNA to bind with miR3p in breast cancer.
circRNA target	35064875	hsa-mir-760	Obesity	The ceRNA network included circORC5/miR5p/TNFRSF10D and circNTRK2/miR-760/LAT, which were dysregulated in obese patients.
circRNA target	35064875	hsa-mir-197	Obesity	The ceRNA network included circORC5/miR5p/TNFRSF10D and circNTRK2/miR-760/LAT, which were dysregulated in obese patients.
circulation_biomarker_diagnosis_ns	35064698	hsa-mir-125a	Rhinitis, Allergic	Aberrant expressions of circulating lncRNA NEAT1 and microRNA-125a are linked OBJECTIVE: Long noncoding RNA nuclear enriched abundant transcript 1 (lnc-NEAT1) and its target microRNA-125a (miR-125a) are reported to regulate immune and inflammation process in allergic rhinitis (AR). CONCLUSION: Circulating lnc-NEAT1 and miR-125a are aberrantly expressed and linked with Th2 cells and symptom severity in pediatric allergic rhinitis.
circulation_biomarker_diagnosis_ns	35064606	hsa-mir-126	Pulmonary Disease, Chronic Obstructive	CONCLUSION: Dysregulated circulating miR-126 not only relates to COPD susceptibility and its acute exacerbation risk but also links with disease severity and inflammatory cytokines in COPD patients.
genetics_overexpression_promote	35064454	hsa-mir-4463	Colonic Neoplasms	Western blotting assay was used to determine the protein level of the target gene PPP1R12B in CRC cells under the transfections of miR-4463 mimic, inhibitor and vectors overexpressing PPP1R12B.
genetics_overexpression_suppress	35064360	hsa-mir-326	Esophageal Squamous Cell Carcinoma	The rescue experiments revealed that miR-326 inhibitor could reverse the negative regulation of circ-ATIC silencing on ESCC progression, and ID1 overexpression also inverted the inhibitory effect of miR-326 on ESCC progression. Our study showed that circ-ATIC facilitated the progression of ESCC by regulating the miR-326/ID1 axis, indicating that circ-ATIC might be a target for ESCC treatment.
genetics_knock down_suppress	35064359	hsa-mir-654	Squamous Cell Carcinoma of Head and Neck	3p knockdown mitigated the influence of circ_CORO1C silence on LSCC cell progression.
genetics_knock down_promote	35064304	hsa-mir-1184	Triple Negative Breast Neoplasms	Knockdown of hsa_circ_0000732 inhibited TNBC cell proliferation, migration, and invasion by upregulating miR-1184. CONCLUSION: Our present study found that ERbeta2 is upregulated in some TNBC cells and promotes TNBC cell growth, migration and invasion by regulating hsa_circ_0000732 targeting miR-1184.
other	35064290	hsa-mir-10b	Brain Neoplasms	The selected signature of miR-7, miR-21, miR-10b and miR-491 could be used as a highly accurate diagnostic, grading and prognostic biomarker in differentiating various types of brain tumours.
other	35064290	hsa-mir-491	Brain Neoplasms	The selected signature of miR-7, miR-21, miR-10b and miR-491 could be used as a highly accurate diagnostic, grading and prognostic biomarker in differentiating various types of brain tumours.
genetics_GWAS	35064090	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	In addition, approximately 40% of CLL cases bearing T12, 17p(-), and 11q(-) showed unidentified microdeletions of miR-15a/16-1, suggesting that miR-15a/16-1 loss cooperates with such chromosomal alterations in CLL.
genetics_GWAS	35064090	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	In addition, approximately 40% of CLL cases bearing T12, 17p(-), and 11q(-) showed unidentified microdeletions of miR-15a/16-1, suggesting that miR-15a/16-1 loss cooperates with such chromosomal alterations in CLL.
lncRNA target	35063752	hsa-mir-124	Acute Lung Injury	3p targeting PDE4B had a protective effect on LPS-induced ALI by inhibiting the TLR4/NF-kappaB signaling pathway.
lncRNA target	35063587	hsa-mir-145	Cardiomyopathies	CONCLUSION: PVT1 contributed to cardiac fibrosis by increasing HCN1 expression via sponging miR-145, which suggested that targeting PVT1 may be a therapeutic option for cardiac fibrosis and cardiac diseases.
circulation_biomarker_diagnosis_ns	35063208	hsa-mir-375	Hyperglycemia	CONCLUSIONS: A single HFHC meal orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia.
transcription factor target	35063135	hsa-mir-122	Diabetic Nephropathies	5p targeted FOXP2.
lncRNA target	35063035	hsa-mir-1243	Diabetic Retinopathy	CONCLUSION: circZNF532 facilitated HG-induced angiogenesis and inflammation in hRMECs via modulating the miR-1243/CARM1 pathway, suggesting that circZNF532 might be a potential biomarker for DR treatment.
genetics_knock down_promote	35062989	hsa-mir-875	Osteosarcoma	Gain/loss-of-function and rescue assays further indicated that hsa_circ_0069117 could significantly promote the expression of PF4V1 by sponging miR
other	35062922	hsa-mir-181a	Cerebral Palsy	Moreover, hsa_circ_0086354 was predicted as a competitive endogenous RNA for miR-181a, and hsa_circ_0086354 expression was negatively correlated to miR-181a expression in children with CP.
lncRNA target	35062330	hsa-mir-541	Porcine Reproductive and Respiratory Syndrome	Since previous studies have shown that type I interferon could effectively inhibit the replication of PRRSV-2, the present work explored whether miR
other	35062066	hsa-mir-125b	Coronary Artery Disease	APPROACH AND RESULTS: We demonstrated that miR-125b is up-regulated in the human aortas of patients with CAD and is located in macrophages and vascular smooth muscle cells (VSMCs).
lncRNA target	35061559	hsa-mir-21	Fatty Liver	This study evaluated if salidroside (SAL) alleviates high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) by downregulating miR-21.
lncRNA target	35061326	hsa-mir-34b	Carcinoma, Renal Cell	Together, these results suggest that ERbeta may increase CSC population in ccRCC via altering ERbeta/circPHACTR4/miR-34b-5p/c-Myc signaling and that targeting this newly identified signal pathway may help physicians to better suppress ccRCC progression.
genetics_overexpression_promote	35060646	hsa-mir-599	Glioma	CONCLUSION: Hsa_circ_0000285 is overexpressed in the glioma and promotes its progression by directly regulating the miR-599/GNG12 axis. This novel mechanism, therefore, shows that the hsa_circ_0000285/miR-599/GNG12 axis may be a promising therapeutic target for glioma treatment.
genetics_overexpression_promote	35060474	hsa-mir-505	Borna Disease	The expression of HMGB1 was up-regulated after BoDV-1 infection, and overexpression of miR-505 could inhibit the expression of HMGB1.
genetics_overexpression_promote	35060363	hsa-mir-125a	Neuroblastoma	Overexpression of HDAC2 or PHOX2B rescued the effects of miR-125a on NB cell proliferation, apoptosis, and differentiation.
target gene	35060347	hsa-mir-204	Cardiomegaly	The microRNA-204-5p inhibits APJ signalling and confers resistance to cardiac hypertrophy and dysfunction.
genetics_overexpression_promote	35060207	hsa-mir-21	Brain Ischemia	Both RLIPostC and overexpression of miR
lncRNA target	35060203	hsa-mir-218	Pancreatic Carcinoma	CONCLUSION: Hsa_circ_0050102 expedited the expansion of PC through growing PPME1 abundance by adjusting miR
genetics_overexpression_promote	35060189	hsa-mir-186	Squamous Cell Carcinoma of Head and Neck	5p, and FNDC3B, FNDC3B overexpression relieved the negative function of silencing circRNA_0001971 in OSCC cells.
other	35060166	hsa-mir-1254	Breast Neoplasms	Then, reverse-transcription quantitative polymerase chain reaction (RT-qPCR) analysis indicated a lower expression level of miR-1254 in breast cancer specimens, compared to their normal pairs. These results suggest miR-1254 as a potential therapeutic candidate for breast cancer subtypes.
lncRNA target	35060113	hsa-mir-516b	Lung Neoplasms	Circ_PDZD8 and GOLT1A were increased, miR-516b-5p was decreased in lung carcinoma tissues and cell lines. Circ_PDZD8 might mitigate the inhibitory effect of Lido on tumor cell malignancy by modulating the miR-516b-5p/GOLT1A axis, providing a novel insight for lung carcinoma treatment.
genetics_overexpression_suppress	35060072	hsa-mir-130b	Down Syndrome	Children with DS presented six differentially expressed miRNAs (DEmiRs): four overexpressed (miR-378a-3p, miR-130b-5p, miR
genetics_overexpression_suppress	35060072	hsa-mir-452	Down Syndrome	Children with DS presented six differentially expressed miRNAs (DEmiRs): four overexpressed (miR-378a-3p, miR-130b-5p, miR
genetics_overexpression_suppress	35060072	hsa-mir-942	Down Syndrome	Children with DS presented six differentially expressed miRNAs (DEmiRs): four overexpressed (miR-378a-3p, miR-130b-5p, miR
genetics_overexpression_suppress	35060072	hsa-mir-668	Down Syndrome	Children with DS presented six differentially expressed miRNAs (DEmiRs): four overexpressed (miR-378a-3p, miR-130b-5p, miR
genetics_overexpression_suppress	35060072	hsa-mir-378a	Down Syndrome	Children with DS presented six differentially expressed miRNAs (DEmiRs): four overexpressed (miR-378a-3p, miR-130b-5p, miR
circulation_biomarker_diagnosis_up	35060046	hsa-mir-576	Alzheimer Disease	3p expression in serum was downregulated in the AD group compared to the health control group.
genetics_overexpression_promote	35059968	hsa-mir-1246	Breast Neoplasms	Overexpression of PGRN and DYRK1A promoted cell proliferation and migration of TNBC, but this effect was reversed by co-expression of miR-1246 mimics.DYRK1A and PGRN act together to regulate the occurrence and development of breast cancer through miR-1246.
genetics_knock down_suppress	35059934	hsa-mir-186	Stomach Neoplasms	In vivo, circZNF131 knockdown hindered GC tumor growth by regulating the miR
lncRNA target	35059924	hsa-mir-214	Nasopharyngeal Carcinoma	Total RNAs were isolated from NPC and adjacent non-tumor tissues from 60 NPC patients and subjected to RT-qPCR to analyze differential expression of lncAMPC and miR-214. Therefore, lncAMPC might downregulate PTEN via miR-214 to increase NPC cell proliferation.
genetics_knock down_promote	35059468	hsa-mir-224	Glioblastoma	5p knockout cells.
lncRNA target	35059460	hsa-mir-21	Breast Neoplasms	In conclusion, we found that lncRNA GAS5 sensitized breast cancer cells to ionizing radiation by inhibiting DNA repair and suppressing miR-21, identifying novel targets for breast cancer radiosensitization.
transcription factor target	35059323	hsa-mir-155	Chlamydia Infections	The data indicates that NK cells promote M1 polarization through up-regulation of miR-155 in macrophages by producing IFN-gamma during chlamydial infection, and NK-regulated macrophage polarization is functionally relevant to host defense against the infection.
epigenetics	35058921	hsa-mir-23b	Asthma, Chronic	Our results indicated that promotor hypomethylation mediated upregulation of miR-23b-3p targets PTEN to promote EMT in chronic asthma.
epigenetics	35058523	hsa-mir-124-2	Breast Neoplasms	Experimental validation on our initially identified genes, in an independent cohort of BP and in BBM and their originating primary breast tumours using Combined Bisulphite and Restriction Analysis (CoBRA) and Methylation Specific PCR identified three genes (RP11-713P17.4, MIR124-2, NUS1P3) that are hypermethylated and three genes (MIR3193, CTD-2023M8.1 and MTND6P4) that are hypomethylated in breast to brain metastases.
epigenetics	35058523	hsa-mir-193	Breast Neoplasms	Experimental validation on our initially identified genes, in an independent cohort of BP and in BBM and their originating primary breast tumours using Combined Bisulphite and Restriction Analysis (CoBRA) and Methylation Specific PCR identified three genes (RP11-713P17.4, MIR124-2, NUS1P3) that are hypermethylated and three genes (MIR3193, CTD-2023M8.1 and MTND6P4) that are hypomethylated in breast to brain metastases.
circulation_biomarker_diagnosis_ns	35057921	hsa-mir-1246	Breast Neoplasms	With this system, we have detected piR-651 and miR-1246 in 10(6) particles muL(-1) MCF-7 cell-secreted exosomes, and successfully performed a direct plasma biopsy to diagnose breast cancer with sensitivity and specificity both at 100% in cohorts of 21 breast cancer patients and 13 healthy controls.
circulation_biomarker_diagnosis_down	35057893	hsa-let-7b	Carcinoma, Hepatocellular	Targeted nanoparticle Ab-miR-NPs mediated the delivery of miR let-7b-5p to the HCC cytoplasm and released miRNA after being broken down, down-regulating the expression of IGF1R and inhibiting AKT/mTOR and Ras/Raf signal transmission.
target gene	35057866	hsa-mir-125b	Breast Neoplasms	Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis.
lncRNA target	35057851	hsa-mir-377	Carcinoma, Hepatocellular	3p suppresses fatty acid oxidation by preventing fatty acid from entering into mitochondria and decreasing ATP production in HCC cells.
transcription factor target	35056756	hsa-mir-126	Carcinoma, Hepatocellular	5p is a biomarker and a potential new treatment target in the progression of HCC via promoting the expression of TDO2.
other	35055320	hsa-mir-200b	Breast Neoplasms	We discovered that high expression levels of miR-190b in breast tumor tissue indicate a positive ER status, and miR-423 and miR-200b levels differ between patients with and without HER2 amplification.
other	35055320	hsa-mir-190b	Breast Neoplasms	We discovered that high expression levels of miR-190b in breast tumor tissue indicate a positive ER status, and miR-423 and miR-200b levels differ between patients with and without HER2 amplification.
other	35055320	hsa-mir-21	Breast Neoplasms	We also found that miR-21 expression depends on HER2 expression in ER- and/or PR-positive BC.
other	35055320	hsa-mir-423	Breast Neoplasms	We discovered that high expression levels of miR-190b in breast tumor tissue indicate a positive ER status, and miR-423 and miR-200b levels differ between patients with and without HER2 amplification.
transcription factor target	35055127	hsa-mir-125b	Abortion	Overall, our results demonstrated that miR-125b can affect embryo implantation through modulating placenta angiogenesis and trophoblast cell invasion capacity that can lead to PL.
other	35054986	hsa-mir-20	Muscular Atrophy	3p is a significant mediator of muscle wasting in obesity.
other	35054986	hsa-mir-20	Obesity	3p is a significant mediator of muscle wasting in obesity.
circulation_biomarker_diagnosis_ns	35054494	hsa-mir-27b	Pre-Eclampsia	The findings show that miR-27b-3p and miR-92b-3p expression was significantly changed at 11-14 and 24-26 weeks of gestation in the blood plasma of pregnant women with early-onset PE, which subsequently manifested.
other	35054341	hsa-mir-124	Endometriosis	Among the 57 miRNAs with an AUC >/= 0.6: 20 had never been reported before; one (miR3p) had previously been observed in endometriosis; and the remaining 36 had been reported in benign and malignant disorders.
other	35054253	hsa-mir-222	Leukemia, Myeloid, Acute	This is the first study focused on examining the GAS5 and miR-222 expression pattern in AML patients.
other	35053622	hsa-mir-566	Colorectal Neoplasms	1-3p and miR-566 enables noninvasive and early detection of CRC.
other	35053622	hsa-mir-129-1	Colorectal Neoplasms	1-3p and miR-566 enables noninvasive and early detection of CRC.
genetics_overexpression_promote	35053428	hsa-mir-21	Stomach Neoplasms	MicroRNA-21 (miR-21) is a small, non-coding RNA overexpressed in gastric cancer and many other solid malignancies, where it exhibits both pro-and anti-tumourigenic properties.
other	35053317	hsa-mir-214	Kartagener Syndrome	5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs.
other	35053317	hsa-mir-218	Kartagener Syndrome	5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs.
other	35053317	hsa-mir-195	Kartagener Syndrome	5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs.
other	35052873	hsa-mir-122	Non-alcoholic Fatty Liver Disease	The expressions of miR-122, -192, and 3p were quantified in total cell-free RNA, global EVs, and liver-specific EVs from control, NAFL, and NASH subjects.
other	35052821	hsa-mir-200c	Colorectal Neoplasms	miR-200c showed a positive correlation with DCN, and the aforementioned lncRNAs exhibited a significant positive correlation with miR-200c expression in metastatic CRC. Our results suggest that DCN as well as miR-200c, MALAT1, lncTCF7 and ZFAS1 contribute to the development of metastases in CRC and that regulation of DCN expression in CRC by ncRNAs is accomplished in an indirect manner.
other	35052815	hsa-mir-146a	Neurogenic Inflammation	Increased expression of the full miR-146a profile, and 3'tRF-IleAAT and 3'tRF-LysTTT was associated with a worse behavioral outcome in animals with chronic neuroinflammation.
other	35052815	hsa-mir-146a	Chronic Disease	Increased expression of the full miR-146a profile, and 3'tRF-IleAAT and 3'tRF-LysTTT was associated with a worse behavioral outcome in animals with chronic neuroinflammation.
lncRNA target	35052738	hsa-mir-92a	Diabetes Complications	Furthermore, additional analysis of potential in silico-identified miR-92a targets in diabetic HCMEC revealed the miR-92a dependent downregulation of an essential metalloprotease, ADAM10.
lncRNA target	35052738	hsa-mir-92a	Diabetes Mellitus	Furthermore, additional analysis of potential in silico-identified miR-92a targets in diabetic HCMEC revealed the miR-92a dependent downregulation of an essential metalloprotease, ADAM10.
lncRNA target	35052701	hsa-mir-671	Glioblastoma	5p inhibition to increasing STAT3 and TRAF2 presentation.
circulation_biomarker_diagnosis_ns	35052352	hsa-mir-4798	Atrial Fibrillation	CONCLUSIONS: Plasma levels of miR
other	35051729	hsa-mir-196a	Barrett Esophagus	In contrast, miR-196a-5p is confirmed as a specific BE marker.
circRNA target	35051313	hsa-mir-520c	Carcinoma, Hepatocellular	miR-520c-3p sponged by circKCNN2 could reverse the inhibitory effect of circKCNN2 on HCC cells and down-regulate the expression of methyl-DNA-binding domain protein 2 (MBD2). CONCLUSIONS: circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis.
genetics_overexpression_suppress	35050556	hsa-mir-1321	Carcinoma, Non-Small-Cell Lung	Functional rescue experiments showed that CDC20 overexpression averted the anti-tumor effects of miR-1321 and miR-7515 on NSCLC cells.
genetics_overexpression_suppress	35050556	hsa-mir-7515	Carcinoma, Non-Small-Cell Lung	Functional rescue experiments showed that CDC20 overexpression averted the anti-tumor effects of miR-1321 and miR-7515 on NSCLC cells.
lncRNA target	35050465	hsa-mir-149	Stomach Neoplasms	Overall, OGFRP1 was determined to promote GC cell proliferation while suppressing cell apoptosis and radiosensitivity by regulating the miR
transcription factor target	35050429	hsa-mir-4510	Stomach Neoplasms	Oxaliplatin treatment may become a specific therapeutic drug for patients with miR-4510 inhibition and GPC3-GC.
genetics_knock down_promote	35050425	hsa-mir-1294	Mesothelioma, Malignant	MiR-1294 restoration also suppressed the proliferation, migration, invasion and stemness of MPM cells, while these effects were abolished by HMGA1 overexpression. CircPLK1 knockdown inhibited MPM cell proliferation, migration, invasion and stemness by targeting the miR-1294/HMGA1 pathway.
circulation_biomarker_diagnosis_ns	35049226	hsa-mir-148	Carcinoma, Non-Small-Cell Lung	OBJECTIVE: To evaluate the diagnostic value of the blood miR-148/152 family to NSCLC by meta-analysis.
circulation_biomarker_diagnosis_ns	35049226	hsa-mir-152	Carcinoma, Non-Small-Cell Lung	OBJECTIVE: To evaluate the diagnostic value of the blood miR-148/152 family to NSCLC by meta-analysis.
lncRNA target	35049152	hsa-mir-137	late onset Parkinson's disease	Collectively, lncRNA OIP5-AS1 promoted NIX expression through competitively binding to miR-137, and promoted mitochondrial autophagy, thus protecting neurons from degeneration which might be seen in patients with PD.
epigenetics	35049148	hsa-mir-424	Carcinoma, Hepatocellular	5p promoter methylation reduced miR
genetics_overexpression_promote	35048795	hsa-mir-133b	Uterine Cervical Neoplasms	miR-133b was overexpressed or silenced in the cervical cancer cell line C33A.
other	35048790	hsa-mir-502	Carcinoma, Hepatocellular	This study demonstrated that the circ-SOX5/miR5p/SYVN1 axis promotes the development of HCC by regulating cell apoptosis.
other	35048507	hsa-mir-149	Triple Negative Breast Neoplasms	5p to increase CDT1 expression.
other	35048477	hsa-mir-1276	Urinary Bladder Neoplasms	The regulatory effects of circ_0002623 and miR-1276 on the expression levels of TGF-beta, WNT1, and SMAD2 in BCa cells were detected by Western blot. We reported that, in BCa tissues and cell lines, circ_0002623 was upregulated, whereas miR-1276 was downregulated.
lncRNA target	35048354	hsa-mir-20b	Stomach Neoplasms	Finally, rescue assays demonstrated that NR2F2-AS1 down-regulated PDCD4 expression to restrain the development of gastric cancer by competitively binding to miR-320b. On the whole, our study revealed the role of NR2F2-AS1/miR-320b/PDCD4 regulatory network in gastric cancer, suggesting NR2F2-AS1 may represent a novel therapeutic target for patients with gastric carcinoma.
other	35048271	hsa-mir-370	Non-alcoholic Fatty Liver Disease	CONCLUSION: Hepatic miR122-Let7 miRNA modulation could be the first insult to NAFLD development, preceding changes in glycemic homeostasis and adiposity.
other	35048271	hsa-let-7	Non-alcoholic Fatty Liver Disease	CONCLUSION: Hepatic miR122-Let7 miRNA modulation could be the first insult to NAFLD development, preceding changes in glycemic homeostasis and adiposity.
other	35048092	hsa-mir-15a	Carcinoma, Renal Cell	Previous work on RCC demonstrated the miRNA15a to be reliable and novel biomarker with 98.1% specificity and 100% sensitivity.
circulation_biomarker_diagnosis_ns	35047559	hsa-mir-96	Colorectal Neoplasms	The High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer.
circulation_biomarker_diagnosis_ns	35047559	hsa-mir-99b	Colorectal Neoplasms	The High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer.
transcription factor target	35047556	hsa-mir-587	Thyroid Cancer, Papillary	In conclusion, these preliminary results indicate that inhibition of miR-3587 promotes HO-1 upregulation, thereby protecting renal tissues from IR-induced ferroptosis.
transcription factor target	35047452	hsa-mir-1246	Breast Neoplasms	To determine the classification performance of a set of miRNA biomarkers (miR-1246, 202, 21, and 219B) useful for breast cancer screening, we determined whether there was a significant difference between the breast cancer and healthy control groups through box plots and the Mann-Whitney U-test, which was further examined in detail by age group.
transcription factor target	35047423	hsa-mir-222a	Hepatitis A	Moreover, upregulated miR-222a could negatively regulate DHAV-1 replication in DEFs and downregulate integrin subunit beta 3 (ITGB3) expression by targeting the 3' untranslated region (3'UTR), indicating that miR-222a may modulate DHAV-1 replication via interaction with ITGB3. In conclusion, the results reveal changes of mRNAs and miRNAs during DHAV-1 infection and suggest miR-222a as an antiviral factor against DHAV-1.
circulation_biomarker_prognosis_ns	35047407	hsa-mir-223	Uterine Cervical Neoplasms	Elevated expressions of TPD52 and miR-223 and reduced expressions of KLF9 and PKC in peripheral blood of cervical cancer patients may serve as predictors of disease diagnosis and prognosis.
genetics_knock down_promote	35046889	hsa-mir-222	Tuberous Sclerosis	Ddit4 is a direct target of Mir221 and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway.
genetics_knock down_promote	35046889	hsa-mir-221	Tuberous Sclerosis	Ddit4 is a direct target of Mir221 and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway.
lncRNA target	35046806	hsa-mir-216a	Atherosclerosis	Conclusion: Our findings indicated that Rb2 might be a potential therapeutic molecule for atherosclerosis by attenuating the atherosclerosis plaque lesion, lipid accumulation, and M1 macrophages polarization by targeting miR-216a.
lncRNA target	35046724	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Our findings suggest that miR-3195 may be used as a prognostic biomarker for NSCLC and is likely to act as a tumor suppressor for NSCLC.
circulation_biomarker_diagnosis_ns	35046680	hsa-mir-26a	Diabetes Mellitus, Type 2	METHODS: Serum miR-26a-5p and RNF6 levels were detected in T2D patients and healthy volunteers via qRT-PCR.
transcription factor target	35046625	hsa-mir-217	Colitis	CONCLUSION: The protective effects of rSj16 on colitis is related to apoptosis and miRNA5p may be a further target for therapeutic intervention against IBD.
circulation_biomarker_diagnosis_up	35046398	hsa-mir-130a	Carcinoma, Hepatocellular	Upon the determination of the optimal concentration of dexmedetomidine, HCCLM3 cells were treated with dexmedetomidine, miR-130a- or EGR1-related oligonucleotides or plasmids were transfected into cells to explore their functions in cell biological behaviors.
genetics_knock down_suppress	35046388	hsa-mir-135b	Colorectal Neoplasms	Knockdown of miR-135b decreased the expression level of SPOCK1, glucose consumption and lactic secretion in CRC patient-derived tumours organoids (CRC tPDOs). Thus, combination with miR-135b antisense nucleotides may represent a novel strategy to sensitise CRC to the chemo-reagent based treatment.
genetics_knock down_promote	35046387	hsa-mir-503	Carcinoma, Non-Small-Cell Lung	NSCLC cell lines (A549 and H1299) were applied for loss-of-function and gain-of-function tests to identify the functional roles of JMJD2C, MALAT1, miR
lncRNA target	35045986	hsa-mir-183	Carcinoma, Hepatocellular	These data support a model wherein circRPN2 inhibits HCC aerobic glycolysis and metastasis via acceleration of ENO1 degradation and regulation of the miR5p/FOXO1 axis, suggesting that circRPN2 represents a possible therapeutic target in HCC.
circulation_biomarker_diagnosis_up	35045800	hsa-mir-18a	Arthritis, Rheumatoid	Furthermore, lncRNA CASC2 and miR-18a-5p expression in the serum samples of RA patients and healthy controls were measured via reverse transcription-quantitative PCR.
other	35045793	hsa-let-7	Pinta	The networks revealed 29 hub microRNAs (e.g., Let-7 family, miR3p.) and 19 hub tRFs (e.g., tRF3-Thr-AGT, i-tRF-Met-CAT) in PAITA.
transcription factor target	35045746	hsa-mir-383	Breast Neoplasms	5p, thereby inhibiting proliferative, migratory, and invasive abilities and promoting apoptosis of BC cells.
lncRNA target	35045733	hsa-mir-421	Carcinoma, Non-Small-Cell Lung	Conclusion: MiR-421 promotes lipid metabolism through targeting PTEN via PI3K/AKT/mTOR pathway activation in NSCLC, indicating that miR-421 can be a latent therapeutic target for NSCLC.
transcription factor target	35045633	hsa-mir-181a	Non-alcoholic Fatty Liver Disease	miR-181a may affect the pathogenesis and progression of nonalcoholic fatty liver disease by inhibiting the expression of silencing information regulator 2 related enzyme 1.
genetics_knock down_promote	35045525	hsa-mir-1204	Colorectal Neoplasms	CircITFG2 knockdown or miR-1204 overexpression abolished lidocaine-induced inhibition in proliferation, metastasis and promotion in apoptosis in CRC cells.
other	35045349	hsa-mir-885	Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	CEND1 (fold change = 5.67) and miR885 (fold change = 8.91) were validated as having significantly different gene expressions between the SCA and NCA groups.
other	35045349	hsa-mir-885	Nasopharyngeal Carcinoma	CEND1 (fold change = 5.67) and miR885 (fold change = 8.91) were validated as having significantly different gene expressions between the SCA and NCA groups.
genetics_knock down_suppress	35044621	hsa-mir-92a-2	Myocardial Infarction	MiR-92a-2 overexpression significantly enhanced the protective effect of HOTTIP knockdown against AMI through partially inhibiting c-Met expression. Our results demonstrated that HOTTIP downregulation attenuated AMI progression via the targeting miR-92a-2/c-Met axis and suggested that HOTTIP might be a potential therapeutic target for AMI.
other	35044282	hsa-mir-199a	Leukemia, Myeloid, Acute	In this series, decreased expression of miR199a was associated with inadequate treatment response and worse OS in pediatric AML patients, indicating its potential as a prognostic biomarker for pediatric AML.Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.2022045.
transcription factor target	35044231	hsa-mir-192	Diabetes Complications	CSE/H(2)S/YB-1/Drosha/miR-192 is a potential therapeutic target pathway for treating diseases, including organ ischemia and diabetic complications.
circulation_biomarker_diagnosis_ns	35044231	hsa-mir-192	Plaque, Atherosclerotic	In human atherosclerotic plaques, miR-192 levels were positively correlated with the plasma H(2)S concentrations.
circRNA target	35044104	hsa-mir-598	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Our results revealed that circ_0007580 might be a target for improving the radiosensitivity of NSCLC, which was mainly achieved by regulating the miR-598/THBS2 axis.
lncRNA target	35043728	hsa-mir-490	Pancreatic Carcinoma	5p played an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating epithelial-mesenchymal transition (EMT), which was partially offset by MAGI2-AS3.
transcription factor target	35043644	hsa-mir-431	Myocardial Infarction, Acute	5p protected cardiomyocytes from AMI injury via restoring the expression of SELT, providing new ideas for the treatment of AMI.
other	35042949	hsa-mir-340	Hypertension, Pulmonary	These results provided evidences that miR5p regulated MFF-SIRT1/3 axis to improve mitochondrial homeostasis and proliferation-apoptosis imbalance of hypoxia-treated PAMSCs, which provided a theoretical basis for the prevention and treatment of PAH.
circulation_biomarker_diagnosis_ns	35042243	hsa-mir-10a	Lung Neoplasms	This study assessed the action of dexmedetomidine (DEX) on oxidative stress (OS) and microRNA 10a (miR-10a) in patients with lung cancer. CONCLUSION: DEX can reduce postoperative OS and plasma miR-10a level in patients with lung cancer, and high expression of miR-10a predicts a high incidence of postoperative pulmonary complications.
lncRNA target	35042223	hsa-mir-466	Carcinoma, Non-Small-Cell Lung	The potential miR involved in the chemo-resistance of NSCLC cells was explored via a series of bioinformatics analyses, and miR-466 was selected.
exosome	35042119	hsa-mir-223	Arthritis, Rheumatoid	AIMS: The current research aimed to investigate the therapeutic effect of microRNA (miR)-223 in exosomes secreted by BMSCs on immune response in the progression of RA. CONCLUSION: Taken together, these findings suggest that miR-223 carried by BMSCs-derived exosomes targets NLRP3 to regulate the activation of inflammasomes, which therefore can be served as a possible therapy for RA.
other	35041823	hsa-mir-122	Esophageal Squamous Cell Carcinoma	Additionally, LINC01410/miR5p/PKM2 axis affecting ESCC metastasis and EMT in vitro and in vivo.
transcription factor target	35041806	hsa-mir-19b	Cognition Disorders	These in vivo and in vitro findings indicate that the upregulation of miR-19b-3p exacerbates CRS-induced abnormal synaptic plasticity and cognitive impairment by targeting Drebrin.
transcription factor target	35041806	hsa-mir-19b	Rubella Syndrome, Congenital	These in vivo and in vitro findings indicate that the upregulation of miR-19b-3p exacerbates CRS-induced abnormal synaptic plasticity and cognitive impairment by targeting Drebrin.
other	35041543	hsa-mir-203	Carcinoma, Non-Small-Cell Lung	3p to promote NSCLC development.
circRNA target	35041407	hsa-mir-181d	Myocardial Reperfusion Injury	Silencing of circ_ZNF512 attenuated its binding to miR-181d-5p, which in turn impaired the EGR1 expression by targeting its 3'-UTR, thus promoting the autophagy of cardiomyocytes and suppressing cell apoptosis to alleviate myocardial tissue injury.
circulation_biomarker_diagnosis_ns	35041299	hsa-mir-181a	Colorectal Neoplasms	Clinically, high levels of serum EV containing miR-181a-5p was positively correlated with liver metastasis in CRC patients.
lncRNA target	35041255	hsa-mir-138	Non-alcoholic Fatty Liver Disease	5p inhibitor also promoted lipid metabolism and inhibited inflammatory response in NAFLD via PGC-1alpha activation.
genetics_overexpression_promote	35040749	hsa-let-7g	Cholangiocarcinoma	This study aimed to identify the mechanisms of long non-coding RNA (lncRNA) TMPO Antisense RNA 1 (TMPO-AS1), microRNA let-7 g-5p, and high-mobility group A1 (HMGA1) proteins in CHOL. Our results, through quantitative real-time PCR and Western blot detection, showed that TMPO-AS1 and HMGA1 were overexpressed while let-7 g-5p was underexpressed in CHOL.
circRNA target	35040370	hsa-mir-339	Osteoporosis	Overall, this study uncovered the role of circ_0001795/miR5p/YAP1 axis in regulating osteogenic differentiation, indicating that targeting Circ_0001795 could serve as a novel therapeutic target for OP.
circulation_biomarker_diagnosis_up	35040271	hsa-mir-181b	Small Cell Lung Carcinoma	METHODS: Blood samples were collected from 30 SCLC patients and 30 non-SCLC patients in our department from 2017 to 2019 to detect the expression level of miR-181b.The expression level of miR-181b was detected in SCLC cells by RT-PCR, and screening of downstream target genes by gene chip, verification with luciferase, and Western blotting.
lncRNA target	35040191	hsa-mir-4726	Carcinoma, Hepatocellular	Taken together, our study revealed that SM inhibited the growth of HCC and enhanced the anticancer effect of SF through HOTTIP-TUG1/miR5p/MUC1 signaling pathway.
genetics_knock down_suppress	35039981	hsa-mir-377	Neuroblastoma	CircKIF2A knockdown impedes cell proliferation, metastasis, and glycolysis partly by regulating the miR
genetics_knock down_promote	35039980	hsa-mir-30	Colorectal Neoplasms	5p overexpression or circ_0000467 knockdown on CRC cell progression.
other	35039944	hsa-mir-298	COVID-19	We propose that our results convincingly suggest that circ_3205 is a circRNA synthesized by SARS-CoV-2 upon host cell infection and that it may behave as a competitive endogenous RNA (ceRNA), sponging hsa-miR-298 and contributing to the upregulation of KCNMB4 and PRKCE mRNAs.
genetics_knock down_promote	35039938	hsa-mir-221	Mucocutaneous Lymph Node Syndrome	3p had a better value for diagnosis IVIG resistance in children with KD than Kobayashi Score with the AUC of 0.811 (95% CI, 0.672-0.951), 0.793 (95% CI, 0.618-0.968), respectively.
lncRNA target	35039898	hsa-mir-27a	Glioblastoma	CONCLUSION: GBM-derived EVs were internalized by GBM cells, released miR-27a-3p into GBM cells, upregulated miR-27a-3p expression, and targeted BTG2, thus promoting TMZ resistance.
lncRNA target	35039872	hsa-mir-141	Pancreatic Carcinoma	Reverse transcriptionquantitative PCR was performed to assess the expression levels of CTBP1AS2, microRNA (miR)1413p and ubiquitinspecific protease 22 (USP22) mRNA in pancreatic carcinoma tissues and cell lines. In conclusion, lncRNA CTBP1AS2 may be involved in pancreatic carcinoma progression by regulating miR1413p and USP22 expressions; in addition, CTBP1AS2 may be a diagnostic biomarker and treatment target for pancreatic carcinoma.
lncRNA target	35039758	hsa-mir-345	Intervertebral Disc Degeneration	Circ_0004354 might compete with circ_0040039 to induce the development of IVDD by modulating miR3p-FAF1/TP73 axis-mediated PAoptosis, inflammatory response, growth inhibition, and ECM degradation of NPCs.
transcription factor target	35039635	hsa-mir-378a	Prostatic Neoplasms	Our data provides a rational for a new PCa stratification strategy based on miR expression, and it reveals that miR-378a and GLUT1 are potential therapeutic targets in highly aggressive glycolytic PCa.
circulation_biomarker_diagnosis_up	35039547	hsa-mir-548j	Peripheral Arterial Disease	Our results demonstrated that circulating miR-548j-5p was significantly reduced in patients with PAD as compared with the controls. In conclusion, our data indicated that up-regulation of miR-548j-5p promotes angiogenesis in ischemic tissue and may represent a novel therapeutic approach for PAD.
other	35039478	hsa-mir-618	Stomach Neoplasms	Additionally, upregulation of EDDM3A in GC is at least partially mediated by downregulation of miR-618.
lncRNA target	35038955	hsa-mir-665	Non-alcoholic Fatty Liver Disease	3p as an endogenous positive regulator of NAFLD via inactivating FNDC5/AMPKalpha pathway, and inhibiting miR
genetics_overexpression_promote	35038953	hsa-mir-1287	Osteosarcoma	Overexpression of miR
lncRNA target	35038704	hsa-mir-494	Diabetic Nephropathies	3p aggravates renal fibrosis, EMT process, and cell apoptosis by targeting SOCS6, suggesting that the miR
lncRNA target	35038619	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	Dual-inhibition of circFOXO3 and its target miRNAs suppressed the reduction of cell proliferation, migration and invasion induced by siRNA of circFOXO3 (si-circFOXO3), demonstrating that the effect of circFOXO3 on NSCLC was dependent on sponging miR
exosome	35038580	hsa-mir-141	Urinary Bladder Neoplasms	In conclusion, exosome-derived circTRPS1 from BCa cells can modulate the intracellular reactive oxygen species (ROS) balance and CD8+ T cell exhaustion via the circTRPS1/miR141-3p/GLS1 axis.
lncRNA target	35038560	hsa-mir-34a	Congenital central hypoventilation syndrome	The objective of this study is to determine whether ethanol exposure can suppress NCC migration through inhibiting EMT and whether microRNA-34a (miR-34a) is involved in the ethanol-induced impairment of EMT in NCCs.
lncRNA target	35038081	hsa-mir-516b	Glioma	CircCCNB1 regulated glioma cell progression and CCND1 expression by miR-516b-5p and HuR. CircCCNB1 aggravated glioma cell growth by elevating CCND1 through targeting miR-516b-5p and HuR.
transcription factor target	35038059	hsa-mir-27a	Multiple Myeloma	METTL3 affected the growth, apoptosis, and stemness of MM cells through accelerating the stability of YY1 mRNA and the maturation of primary-miR-27a-3p in vitro and in vivo.
genetics_overexpression_promote	35037949	hsa-mir-1	Adenocarcinoma of Lung	5p on LUAD cell functions were attenuated by TNS1 overexpression to some extent.
lncRNA target	35037833	hsa-mir-195	Stomach Neoplasms	In conclusion, LINC00662 facilitates the malignant biological behaviors of GC cells via miR5p/CEP55 axis, and therefore, it may be a promising target for GC treatment.
genetics_overexpression_promote	35037826	hsa-mir-648	Adenocarcinoma of Lung	Overexpression of miR-3648 significantly enhanced cell proliferation, migration, and invasion abilities in LUAD cells.
circulation_biomarker_prognosis_up	35037761	hsa-mir-93	Colorectal Neoplasms	The expression pattern of tissue and circulating miR
genetics_knock down_promote	35037694	hsa-mir-338	Squamous Cell Carcinoma of Head and Neck	3p can inhibit the proliferation of LSCC cells, while co-transfection of overexpression of ROR2 can partially reverse this change.
lncRNA target	35037556	hsa-mir-600	Carcinoma, Hepatocellular	Our findings reveal the key role of LINC01273 in sorafenib-resistant HCC cells, and targeting of the newly identified LINC01273/miR-600/METTL3 feedback regulatory axis may be a promising effective intervention for HCC patients with sorafenib resistance.
genetics_knock down_promote	35037349	hsa-mir-924	Carcinoma, Non-Small-Cell Lung	Moreover, the suppressive effect of miR-924 on NSCLC progression was reversed by SRSF7 overexpression.
genetics_GWAS	35037107	hsa-mir-34a	Glioblastoma	Our findings provide insight into understanding the molecular mechanism of GBM chemoresistance to TMZ and facilitating to develop novel treatment strategy to combat p53-mutant GBM by targeting miR-34a/WNT6 axis.
circRNA target	35037032	hsa-mir-382	Stomach Neoplasms	Collectively, Circ_0000190 suppressed GC progression via miR
other	35036174	hsa-mir-21	Distal myopathy, Nonaka type	chi-miR5p, ipu-miR-99b and bta-miR-26a were up-regulated in UM among the 10 most differentially expressed miRNAs.
lncRNA target	35036160	hsa-mir-15a	Atrial Fibrillation	Taken together, the miR-15a-5p/Smad7 pathway might be a potential target for AF therapy.
genetics_overexpression_promote	35036112	hsa-mir-100	Breast Neoplasms	5p overexpression or CDC25A suppression may contribute to BC diagnosis.
genetics_overexpression_promote	35036071	hsa-mir-874	Ventricular Premature Complexes	3p, the predicted target of circSmoc1-2, promotes VC, while overexpression of circSmoc1-2 reduces VC by suppressing miR
exosome	35036060	hsa-mir-9	Diabetic Retinopathy	In this study, we demonstrated that exosomes collected from the vitreous humor of proliferative diabetic retinopathy patients promoted proliferation, migration and tube formation ability of primary human retinal endothelial cells via its elevated miR3p expression level.
lncRNA target	35036056	hsa-mir-17	Melanoma	In this study, the results demonstrated that miR-17, which was downregulated in melanoma stem cells, acted as a tumor inhibitor by suppressing the stemness of melanoma stem cells and promoting cell differentiation. MiR-17 targeted ADAR2 (adenosine deaminase acting on RNA 2), a gene encoding an editing enzyme required for the maintenance of melanoma stem cell stemness.
lncRNA target	35035856	hsa-mir-372	Sepsis	It is concluded that, in LPS-induced HK-2 cell injury, ZFAS1 has a protective role via modulating the miR3p/PPARalpha axis, suggesting the potential of ZFAS1 as a protective target for septic AKI.
lncRNA target	35035814	hsa-mir-20a	Carcinoma, Non-Small-Cell Lung	We concluded that LDLRAD3 exerted oncogenic effects via the miR-20a-5p-SLC7A5 axis to activate the mTORC1 signaling pathway in NSCLC.
other	35035811	hsa-mir-155	Gallbladder Neoplasms	In this study, we have investigated the role and clinical significance of miR-155 in a Chinese population suffering from GBC and compared the results with nonneoplastic inflammation.
other	35035811	hsa-mir-145	Gallbladder Neoplasms	Further results noted were that miR5p expressed genes mimic the gene expression of STAT1, a downregulation of IRF7 was noted in the GBC, and an activation of STAT1 was significantly noted in carcinoma cells of the gallbladder.
target gene	35035750	hsa-mir-125a	Carcinoma, Hepatocellular	miR-125a-5p-targeted regulation of TRA2β expression inhibits proliferation and metastasis of hepatocellular carcinoma cells.
target gene	35035706	hsa-mir-140	Breast Neoplasms	Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P.
genetics_overexpression_promote	35035705	hsa-mir-200c	Opitz GBBB Syndrome, X-Linked	Taok1 overexpression could reverse the protective action of miR-200c-3p overexpression on the OS injury of HEI-OC1 cells.
lncRNA target	35035705	hsa-mir-200c	Cochlear Diseases	OBJECTIVE: The aim of this study was to elucidate the role of miR-200c-3p in cochlear hair cells injured by oxidative stress (OS) and the underlying mechanisms. CONCLUSIONS: Given the capacity of miR-200c-3p to suppress the OS and apoptosis of HEI-OC1 cells via targeting Taok1, it can be a novel and potential therapeutic target for cochlear hair cell injury.
genetics_overexpression_promote	35035684	hsa-mir-98	Nasopharyngeal Carcinoma	5p overexpression on the NPC cells (all P<0.05).
other	35035663	hsa-mir-193a	Coronary Disease	In addition, TBX1 and miR-193a-3p expression was significantly downregulated and TGF-beta2 levels were high in human embryonic CHD tissues, as indicated by the H9c2 cell experiments. In summary, the TBX1/miR-193a-3p/TGF-beta2 axis mediates CHD by inducing ferroptosis in cardiomyocytes.
transcription factor target	35035482	hsa-mir-223	Stomach Neoplasms	In summary, our findings reveal that miR-223 increases tumor progression in GC by targeting RhoB, suggesting that it could serve to be a potential biomarker for the prediction of the disease.
transcription factor target	35034634	hsa-mir-194	Lung Neoplasms	Sp1 inhibited CD44 expression by increasing the expression of miR
circulation_biomarker_diagnosis_up	35034594	hsa-mir-210	Lupus Erythematosus, Systemic	CONCLUSION: The dysregulation of circulating miR-210/HIF-1alpha levels in SLE/ photosensitivity patients is controlled by the presence of additional pathological complications, and results suggest that the hypoxia pathway might interact positively with the pathogenesis and disease progression of SLE.
circRNA target	35034587	hsa-mir-145	Diabetic Cardiomyopathies	Hence, circ_0071269 may promote the development of DCM through the miR-145/GSDMA axis and thus provide a novel marker for the treatment of DCM.
lncRNA target	35034584	hsa-mir-155	C syndrome	albicans and significant improvement of histological damage by CGA-N12 through microRNA-155/SOCS1 axis were proved in this study.
genetics_overexpression_promote	35034572	hsa-mir-655	Carcinoma, Hepatocellular	3p overexpression inhibited HCC cell oncogenic phenotypes mentioned above, which were attenuated by ACER3 up-regulation.
lncRNA target	35034562	hsa-mir-23a	Ovarian Failure, Premature 	In conclusion, TRERNA1 may sponge miR-23a to suppress granulosa cell apoptosis in POF.
lncRNA target	35034548	hsa-mir-200c	Chronic Periodontitis	Consequently, the silencing of NEAT1 inhibits inflammation and apoptosis via targeting miR-200c-3p/TRAF6 axis, thereby contributing to alleviate the progression of CP.
lncRNA target	35034547	hsa-mir-423	Colorectal Neoplasms	Collectively, our results demonstrated that ATF3-activated FOXP4-AS1 aggravates CRC progression by regulating miR5p/NACC1 axis, indicating a new target for CRC treatment.
genetics_overexpression_suppress	35034539	hsa-mir-515	Colon   Adenocarcinoma	5p overexpression reversed the inhibition of COAD cell proliferation and migration by UBXN10-AS1 overexpression, and SLIT3 overexpression counteracted the oncogenicity of miR
lncRNA target	35034538	hsa-mir-129	Cardiomegaly	5p targeted Smurf1 and repressed the ubiquitination of PTEN, and promoted PTEN expression, thus improving the cardiac function of CHF rats.
lncRNA target	35034519	hsa-mir-96	Carcinoma, Non-Small-Cell Lung	Moreover, HOXC-AS3 suppressed the role of miR-96 in inhibiting NSCLC cell invasion and migration.
genetics_overexpression_promote	35034420	hsa-mir-203	Inflammation	CONCLUSION: These experimental data demonstrated the potential inhibitory effects of overexpressed miR-203 on periodontitis development by promoting PDLC differentiation and suppressing inflammatory responses through AP-1/ICAM-1 axis.
genetics_knock down_promote	35034256	hsa-mir-150	Myopia	Gain- and loss-of-function experiments were performed in hypoxia-exposed HSFs to evaluate the effect of the HIF-1alpha/miR
circRNA target	35034254	hsa-mir-636	Carcinoma, Non-Small-Cell Lung	Circ_0025039 silencing repressed NSCLC malignant progression by reducing CORO1C expression through miR-636, showing the possibility of circ_0025039 as a therapeutic target for NSCLC.
genetics_knock down_promote	35034245	hsa-mir-619	Colorectal Neoplasms	Circ-FAT1 knockdown repressed FOSL2 expression by sponging miR
circRNA target	35034206	hsa-mir-221	Stomach Neoplasms	3p were targets of circ_0003159, and the inhibition of miR
circRNA target	35034206	hsa-mir-222	Stomach Neoplasms	3p were targets of circ_0003159, and the inhibition of miR
lncRNA target	35033901	hsa-mir-802	Uterine Cervical Neoplasms	Our study identified circ_0084904 as a novel oncogenic driver in CC depending on the modulation of the miR-802/MAL2 axis, establishing the notion that silencing of circ_0084904 might represent a promising targeted therapy for CC.
other	35033900	hsa-mir-21	Guillain-Barre Syndrome	miR-21 significantly increased the secretion of IL-1 but decreased that of IL-10 in DSCs cells infected with GBS.
other	35033900	hsa-mir-21	Obstetric Labor, Premature	miR-21 differentially regulates IL-1 and IL-10 expression in human decidual Intrauterine infections caused by bacteria like group B streptococcus (GBS) and the subsequent activation of the maternal inflammatory response have been long suspected to be the underlying cause of preterm labor.
other	35033900	hsa-mir-21	Reproductive Tract Infections	miR-21 differentially regulates IL-1 and IL-10 expression in human decidual Intrauterine infections caused by bacteria like group B streptococcus (GBS) and the subsequent activation of the maternal inflammatory response have been long suspected to be the underlying cause of preterm labor.
genetics_overexpression_promote	35033353	hsa-mir-338	Neuroblastoma	CONCLUSION: Overexpression of KLF5 reduced expression of miR-338, which in turn increased the expression of KIF1A and activated the Hedgehog signaling pathway, leading to the progression of NB.
lncRNA target	35033084	hsa-mir-937	Adenocarcinoma of Lung	3p can be used as a therapeutic target and potential biomarker for LUAD.
target gene	35033075	hsa-mir-375	Colorectal Neoplasms	hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway.
transcription factor target	35033060	hsa-mir-10b	Glioblastoma	CONCLUSIONS: We identified U6 snRNA, the key RNA component of the spliceosome, as the top miR-10b target in glioblastoma.
other	35033060	hsa-mir-10b	high grade glioma	Malignant gliomas exhibit particularly striking dependence on miR-10b. We provide evidence of the direct binding between miR-10b and U6, in situ imaging of miR-10b and U6 co-localization in glioma cells and tumors, and biochemical co-isolation of miR-10b with the components of the spliceosome.
lncRNA target	35033021	hsa-mir-22	Ischemic Stroke	CONCLUSIONS: Our findings suggested that CDKN1A/JUN could be a robust and promising gene-pair diagnostic biomarker for IS, regulating ferroptosis during IS progression via C9orf106/C9orf139-miR
lncRNA target	35033021	hsa-mir-429	Ischemic Stroke	CONCLUSIONS: Our findings suggested that CDKN1A/JUN could be a robust and promising gene-pair diagnostic biomarker for IS, regulating ferroptosis during IS progression via C9orf106/C9orf139-miR
transcription factor target	35032930	hsa-mir-424	Endometritis	5p inhibitors and siRNA-IRAK2 revealed that negative regulation of miR
transcription factor target	35032930	hsa-mir-424	Inflammation	5p inhibitors and siRNA-IRAK2 revealed that negative regulation of miR
other	35032791	hsa-mir-346	Pneumonia, Mycoplasma	RESULTS: CircHIPK3 and KCMF1 were downregulated, while miR-346 was upregulated in placenta tissues from PE patients.
other	35032287	hsa-mir-140	Polycystic Ovary Syndrome	3p associated with the PI3K/Akt pathway were found to be up-regulated in granulosa cells of women with PCOS.
other	35032287	hsa-mir-20a	Polycystic Ovary Syndrome	3p associated with the PI3K/Akt pathway were found to be up-regulated in granulosa cells of women with PCOS.
genetics_knock down_suppress	35032277	hsa-mir-496	Osteochondritis Dissecans	Moreover, miR-496 inhibition or PDCD4 overexpression abolished the inhibitory effects of circ_0007290 knockdown OGD-evoked neuronal injury. Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke.
genetics_knock down_suppress	35032277	hsa-mir-496	Ischemic Stroke	Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke.
exosome	35032276	hsa-mir-130a	Glioma	Circ_0037655 relieved SEV-induced glioma growth inhibition in vivo by mediating miR-130a-5p and RPN2 levels.
other	35032098	hsa-mir-6808	Liver Injury	5p were decreased.
other	35032098	hsa-mir-6874	Tuberculosis	5p were decreased.
other	35032098	hsa-mir-6874	Liver Injury	5p were decreased.
other	35032098	hsa-mir-3157	Liver Injury	5p were decreased.
other	35032098	hsa-mir-6808	Tuberculosis	5p were decreased.
other	35032098	hsa-mir-3157	Tuberculosis	5p were decreased.
lncRNA target	35031966	hsa-mir-590	Carcinoma, Non-Small-Cell Lung	Moreover, increasing miR-590 suppressed Yes-associated protein 1 (YAP1) expression and inhibited the Wnt/beta-catenin pathway in NSCLC cells.
other	35031872	hsa-mir-374a	Stomach Neoplasms	5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity).
other	35031872	hsa-mir-186	Stomach Neoplasms	5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity).
other	35031872	hsa-mir-200c	Stomach Neoplasms	5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity).
other	35031872	hsa-mir-429	Stomach Neoplasms	5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity).
other	35031872	hsa-mir-24	Stomach Neoplasms	5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity).
lncRNA target	35031788	hsa-mir-132	Urinary Bladder Neoplasms	Furthermore, miR-132 downregulated the expression of NRF2 to restrict the viability and migratory ability of bladder cancer cells.
genetics_knock down_promote	35031054	hsa-mir-498	Urinary Bladder Neoplasms	Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of beta-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist.
genetics_knock down_promote	35030981	hsa-mir-182	Stomach Neoplasms	GC cell viability and autophagy were inhibited and apoptosis was promoted after circ_0001658 knockdown, and the cellular functions were reversed by downregulating miR-182.
circulation_biomarker_diagnosis_ns	35030978	hsa-mir-99b	Prostatic Neoplasms	MicroRNA-99b-5p (miR-99b-5p) has been shown to be enriched in serum exosomes of prostate cancer (PCa) patients treated with radiotherapy, while its function in PCa progression remains unclear.
lncRNA target	35030971	hsa-mir-942	Osteoporosis	In conclusion, circ_0019693 promotes BMSC osteogenic differentiation osteogenesis-coupled angiogenesis via regulating miR5p-targeted PCP4, thus blocking the development of OP.
lncRNA target	35030969	hsa-mir-214	Prostatic Neoplasms	Our study demonstrated the novel role of the SNHG3/miR3p/TGF-beta axis in tumor growth and bone metastasis in PC, indicating that SNHG3 may act as a biomarker and promising therapeutic target against PC.
lncRNA target	35030964	hsa-mir-761	Osteosarcoma	Rescue experiments showed that low levels of miR-761 or restoration of IRS1 could neutralize the effects of ADIRF-AS1 ablation in OS cells. In summary, ADIRF-AS1 exacerbates the oncogenicity of the OS cells by targeting the miR-761/IRS1 axis.
lncRNA target	35030644	hsa-mir-217	Osteoporosis	CONCLUSIONS: MALAT1 promotes osteogenic differentiation through regulating miR-217/AKT3 axis, suggesting that MALAT1 is a potential target with respect to alleviating osteoporosis.
genetics_knock down_suppress	35030455	hsa-mir-660	Multiple Myeloma	5p overexpression blocked the malignant phenotypes of MM cells by targeting CDK6.
circulation_biomarker_diagnosis_ns	35030371	hsa-mir-484	Multiple Sclerosis, Relapsing-Remitting	Reverse Transcription-quantitative Real-Time PCR (RT-qPCR) was performed to detect the expression levels of APAF-1 and miR-484 in the peripheral blood mononuclear cells (PBMCs) of 34 RRMS patients recruited from the MS clinic of kasr al ainy hospital- faculty of medicine-Egypt and 34 healthy controls.
lncRNA target	35030351	hsa-mir-495	Carcinoma, Renal Cell	Furthermore, MEG8 promoted G3BP1 expression to aggravate ccRCC tumorigenic properties through sponging miR
circulation_biomarker_diagnosis_ns	35030053	hsa-mir-24	Melanoma	MATERIALS AND METHODS: The work was performed on cultured human melanoma Me45 cells, transiently transfected with plasmids containing Renilla luciferase reporter gene targeted by miRNAs Let-7, miR-21 or miR-24.
circulation_biomarker_diagnosis_ns	35030053	hsa-mir-21	Melanoma	MATERIALS AND METHODS: The work was performed on cultured human melanoma Me45 cells, transiently transfected with plasmids containing Renilla luciferase reporter gene targeted by miRNAs Let-7, miR-21 or miR-24.
circulation_biomarker_diagnosis_ns	35029768	hsa-mir-21	Atrial Fibrillation	The effects of non-PAF and levels of miRNA21 and IL-18 in left atrial serum on the recurrence of AF after cryoablation statistically differed (p < 0.05). CONCLUSION: The levels of miRNA21 and IL-18 were higher in left atrial blood than in peripheral blood, which may be related to the severity of AF and recurrence of AF after cryoablation.
lncRNA target	35029589	hsa-mir-542	Urinary Bladder Neoplasms	CONCLUSIONS: Circ_0000515, as a tumor promoter, strengthens the viability, migration and aggressiveness of BC cells via modulating miR
genetics_overexpression_promote	35029520	hsa-mir-381	Stomach Neoplasms	Further, FGFR2 overexpression partly reversed the miR
transcription factor target	35029026	hsa-mir-181a	Triple Negative Breast Neoplasms	In summary, autophagy inhibits cancer stemness through the miR-181a-regulated mechanism in TNBC.
other	35028969	hsa-mir-205	Nasopharyngeal Carcinoma	5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening.
other	35028969	hsa-mir-143	Nasopharyngeal Carcinoma	5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening.
other	35028969	hsa-mir-29c	Nasopharyngeal Carcinoma	5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening.
circulation_biomarker_diagnosis_ns	35028969	hsa-mir-145	Nasopharyngeal Carcinoma	RESULTS: In NPC patients, the expression of five serum miRNAs (miR-29c-3p, miR
circulation_biomarker_diagnosis_up	35028929	hsa-mir-100	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_diagnosis_up	35028929	hsa-mir-143	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_diagnosis_up	35028929	hsa-mir-182	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_diagnosis_up	35028929	hsa-mir-125b	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_diagnosis_up	35028929	hsa-mir-200c	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_diagnosis_up	35028929	hsa-mir-1	Urinary Bladder Neoplasms	5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel.
circulation_biomarker_prognosis_down	35028121	hsa-mir-148a	Carcinoma, Hepatocellular	CONCLUSION: We demonstrated that serum exosomal miR-122 and miR-148a played a predictive role and were linked to prognosis in HCC via interactions with PAX2.
other	35028061	hsa-mir-29c	Nasopharyngeal Carcinoma	RESULTS: Hsa-miR-29c, hsa-miR-30e and hsa-miR-93 were selected from DEMs to construct a signature, and their abnormal expression was significantly associated with poor prognosis of NPC.
other	35028061	hsa-mir-93	Nasopharyngeal Carcinoma	RESULTS: Hsa-miR-29c, hsa-miR-30e and hsa-miR-93 were selected from DEMs to construct a signature, and their abnormal expression was significantly associated with poor prognosis of NPC.
other	35027969	hsa-mir-126	psoriasis 1	Initial miR-126 levels in the buccal epithelium in children with psoriasis are a prognostic criterion for response to therapy and can be used as a marker for prescribing systemic treatment.
lncRNA target	35027936	hsa-mir-148a	Intervertebral Disc Degeneration	CONCLUSION: LncRNA HOTAIR promoted NP cell autophagy and apoptosis via promoting PTEN expression as a ceRNA of miR-148a in IDD.
target gene	35027933	hsa-mir-28	Lymphoma, Large B-Cell, Diffuse	hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3ζ Expression.
exosome	35027847	hsa-mir-216b	Breast Neoplasms	Hypoxic Breast Cancer Cell-Derived Exosomal SNHG1 Promotes Breast Cancer Growth and Angiogenesis via Regulating miR-216b-5p/JAK2 Axis.
lncRNA target	35027543	hsa-mir-135b	Pancreatic Carcinoma	Our results stressed that KLF4, as a vital target of miR-135b-5p, could influence promoter region of GPRC5A, thus affecting the malignant progression of pancreatic cancer.
circulation_biomarker_diagnosis_up	35027539	hsa-mir-637	Stomach Neoplasms	Further mechanism investigation demonstrated that circRELL1 could sponge miR-637 and indirectly unregulated the expression of EPHB3 via modulating autophagy activation in GC. Taken together, this study elucidates the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in GC progression, inspiring for further understanding of the underlying molecular mechanisms of GC and providing a promising novel diagnostic circulating biomarker and therapeutic target in GC.
circRNA target	35027503	hsa-mir-208a	Colorectal Neoplasms	CONCLUSION: CircCUL2 participates in progression via the miR-208a-3p/PPP6C axis in colorectal cancer.
circulation_biomarker_diagnosis_ns	35027490	hsa-mir-21	Breast Neoplasms	The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate BACKGROUND: miRNA 21 exhibits an increased expression in breast cancer (BC).
genetics_overexpression_promote	35027053	hsa-mir-625	Ovarian Neoplasms, High-Grade Serous	RESULTS: Overexpression of miR
other	35026963	hsa-mir-155	Sepsis	This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis.
other	35026963	hsa-mir-29a	Sepsis	This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. A receiver operating characteristic curve (ROC) analysis of miR-21 and miR-29a (0.829 and 0.787 AUC of ROC curves) showed good discrimination for the identification of sepsis from non-sepsis neonates.
other	35026963	hsa-mir-21	Sepsis	This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. A receiver operating characteristic curve (ROC) analysis of miR-21 and miR-29a (0.829 and 0.787 AUC of ROC curves) showed good discrimination for the identification of sepsis from non-sepsis neonates.
other	35026963	hsa-mir-1	Sepsis	This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis.
other	35026963	hsa-mir-146a	Sepsis	This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis.
other	35026768	hsa-mir-129	Parkinson Disease	5p mediated the function of HOTAIR on cognition and oxidative balance in the ISO-managed SD rat model.
other	35026768	hsa-mir-129	Cognition Disorders	5p mediated the function of HOTAIR on cognition and oxidative balance in the ISO-managed SD rat model.
lncRNA target	35026645	hsa-mir-181c	Triple Negative Breast Neoplasms	This study is the first to demonstrate the miR-181c/MAP4K4 signaling in suppressing TNBC, providing a novel therapeutic target for TNBC.
other	35026632	hsa-mir-198	Hemoglobinuria, Paroxysmal	The miRNA-198 has been reported a potential prognostic and early diagnostic marker signature of PC.
circulation_biomarker_diagnosis_ns	35026632	hsa-mir-198	Pancreatic Carcinoma	More importantly, the proposed detection platform can be applied directly to distinguish the expression of miRNA-198 in clinical serum, affording the ability to distinguish pancreatic cancer patients from those of healthy human beings, and quantify the expression variation of miRNA-198 for the pancreatic cancer patients before and after resection, which may pave the way to develop novel clinical diagnostic equipment for cancer diagnosis and therapeutic evaluation.
target gene	35026514	hsa-mir-665	Stomach Neoplasms	Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis.
transcription factor target	35026295	hsa-mir-200a	Glioma	This study proved that EMT promotes the expression of TF in glioma cells through the miR-200a/ZEB1 axis. In summary, these results indicated that EMT can promote the expression of TF in glioma cells via the miR-200a/ZEB1 axis.
exosome	35026284	hsa-mir-29b	Fractures, Bone	Accordingly, the current study sought to determine the functions of microRNA (miR)-29b-3p from BM-MSCs-derived extracellular vesicles (EVs) on the angiogenesis of fracture healing via the PTEN/PI3K/AKT axis.
transcription factor target	35026214	hsa-mir-29a	Uterine Cervical Neoplasms	The role of miR-29a-3p was confirmed using Antago-miR-29a-3p, which reversed the Ang-A-inhibited expression of MMP2 and VEGFA, invasive motility, and angiogenesis in human cervical cancer cells. SIGNIFICANCE: These findings are the first to indicate that in human cervical cancer cells, Ang-A exerts anti-metastatic and anti-angiogenic effects via targeting the miR-29a-3p/MMP2/VEGFA axis, mediated through the ERK pathway.
other	35026193	hsa-mir-146a	Drug Hypersensitivity	Moreover, DAPA elevated expression levels of anti-inflammatory miR-146a, while values of miR-155 decreased in those cells.
other	35026193	hsa-mir-155	Drug Hypersensitivity	Moreover, DAPA elevated expression levels of anti-inflammatory miR-146a, while values of miR-155 decreased in those cells.
genetics_knock down_promote	35025943	hsa-mir-27a	Nervous System Diseases	Among the altered micro-RNAs, miR-27a-3p was found to be downregulated in a number of neurological diseases characterized by loss of inter-endothelial junctions and disruption of the barrier integrity. Thus, miR-27a-3p may constitute a novel therapeutic target that could be exploited to prevent BBB dysfunction and preserves its integrity in neurological disorders characterized by impairment of the barrier's function.
circulation_biomarker_diagnosis_up	35025700	hsa-mir-19b	Fibrosis, Renal	HN rats were injected with miR-19b-3p- or HDAC3-related vectors to figure out their effects on RIF through detecting 24-h urine protein, uric acid (UA), blood urea nitrogen (BUN) and serum creatinine (Scr) contents and alpha-smooth muscle actin (alpha-SMA), transforming growth factor beta1 (TGF-beta1) and fibronectin (FN) contents in renal tissues and observing pathological damages and RIF index of renal tissues.
circulation_biomarker_diagnosis_up	35025700	hsa-mir-19b	Hyperuricemia	HN rats were injected with miR-19b-3p- or HDAC3-related vectors to figure out their effects on RIF through detecting 24-h urine protein, uric acid (UA), blood urea nitrogen (BUN) and serum creatinine (Scr) contents and alpha-smooth muscle actin (alpha-SMA), transforming growth factor beta1 (TGF-beta1) and fibronectin (FN) contents in renal tissues and observing pathological damages and RIF index of renal tissues.
genetics_knock down_promote	35025697	hsa-mir-124	Lung Neoplasms	Loss or gain-of-function experiments of circPVT1 and miR
genetics_knock down_suppress	35025075	hsa-mir-25	Stroke	* miR-25 inhibits loss of neurons and provides neuronal recovery in animal model of stroke via inhibiting HDAC3 and ATXN3.
other	35024240	hsa-mir-148a	Alzheimer Disease	In conclusion, the present study implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feedforward regulation in AD.
target gene	35024096	hsa-mir-4759	Breast Neoplasms	miR-4759 suppresses breast cancer through immune checkpoint blockade.
other	35023957	hsa-mir-195	Adenocarcinoma of Lung	3p expression is significantly associated with poor survival in LUAD, which may be a promising prognostic biomarker for LUAD.
other	35023789	hsa-mir-608	Gestational Trophoblastic Disease	Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.
lncRNA target	35023690	hsa-mir-16	Osteoarthritis	CONCLUSIONS: lncRNA SNHG12 regulates OA development by inhibiting miR
circulation_biomarker_prognosis_ns	35023689	hsa-mir-129	gastric cardia adenocarcinoma	(2) The expression of miR-129 declined in the tissues and serum of GCA patients compared with that in HCs (p < 0.01).
lncRNA target	35023687	hsa-mir-124	Squamous Cell Carcinoma of Head and Neck	Up-regulating miR-124 significantly inhibited TSCC cell migration and proliferation.
circRNA target	35023214	hsa-mir-149	Thyroid Neoplasms	5p to relieve the inhibition of miR
lncRNA target	35023068	hsa-mir-342	Breast Neoplasms	3p inhibitor transfection was conducted to further explore the miR
other	35023059	hsa-mir-144	Parkinson Disease	In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies.
other	35023059	hsa-mir-29a	Parkinson Disease	In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies.
other	35023059	hsa-mir-96	Parkinson Disease	In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies.
other	35023052	hsa-mir-139	Uterine Cervical Neoplasms	Circ_0003221 downregulation restrains cervical cancer cell growth, metastasis, and angiogenesis by governing the miR3p/S100A14 pathway.
genetics_overexpression_promote	35023001	hsa-mir-3918	Glioma	When overexpressed, EGFR can restore the inactivated PI3K/AKT and ERK pathways caused by miR-3918 and influence the glioma cell proliferation and migration.
genetics_GWAS	35022999	hsa-mir-361	Colorectal Neoplasms	In conclusion, VPS9D1-AS1 gene rs7206570 polymorphism affecting hsa-miR
epigenetics	35022519	hsa-mir-375	Breast Neoplasms	This study set out to elucidate the underlying mechanism by which lncRNA UCA1 affects the m(6)A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer.
lncRNA target	35022405	hsa-mir-646	Thyroid Cancer, Papillary	Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1.
circulation_biomarker_diagnosis_up	35022330	hsa-mir-376a	Cholangiocarcinoma	Simultaneously, PSMA3-AS1 primarily localized in the cytoplasm could competitively bind miR-376a-3p to upregulate LAMC1, thereby accelerating CCA progression. This study uncovers that PSMA3-AS1 functions as a cancer-promoting gene in CCA, and PAX5/PSMA3-AS1/miR-376a-3p/LAMC1 axis plays a vital role in CCA development.
genetics_overexpression_promote	35022277	hsa-mir-139	Influenza, Human	Our study demonstrates that the development of naive T cells and generation or differentiation of effector or memory CD8(+) T cell responses to influenza virus infection are not impacted by miR-139 deficiency or overexpression; yet, miR-139(-/-) CD8(+) T cells are outcompeted by wild-type CD8(+) T cells in a competition setting and demonstrate reduced responses to Listeria monocytogenes Using an in vitro model of T cell exhaustion, we confirmed that miR-139 expression similarly does not impact the development of T cell exhaustion.
other	35022242	hsa-mir-408	Joint Dislocations	We also found that the PCY-SAG14 module is repressed by a conserved microRNA, miR408, which in turn is repressed by phytochrome interacting factor 3/4/5 (PIF3/4/5), the key trio of transcription factors promoting DIS.
lncRNA target	35021946	hsa-mir-18a	Nasal Polyps	CONCLUSIONS: STAT1 acts as a transcription factor to promote transcription of miR-18a, and miR-18a targets PTEN to exacerbate the inflammatory response and EMT in CRSwNP.
other	35021944	hsa-mir-155	Behcet Syndrome	Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group.
other	35021944	hsa-mir-326	Behcet Syndrome	Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group.
other	35021944	hsa-mir-181	Behcet Syndrome	Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group.
lncRNA target	35021605	hsa-mir-29	Leukemia, Lymphocytic, Chronic, B-Cell	Importantly, we found that B cells derived from CLL patients had higher expression levels of the miRNA-21 and miRNA-29, which suppresses PTEN translation, compared to healthy donors.
genetics_knock down_promote	35021067	hsa-mir-338	Brain Ischemia	3p knockdown attenuated ischemic injury and simultaneously reduced the microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I ratio, which contributes to neuronal survival after ischemia.
other	35020867	hsa-mir-155	Arthritis, Rheumatoid	Together, these data underpin the notion that miRdriven myeloid cell activation in the synovium contributes not only to inflammation but may also influence the adaptive immune response.
lncRNA target	35020847	hsa-mir-155	Intervertebral Disc Degeneration	Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD.
other	35020440	hsa-mir-204	Graft vs Host Disease	Blockade of miR-204 abolished the effects of MSC-exo, while overloading L929-exo with miR-204 markedly attenuated dry eye. Thus, this study suggests that MSC-exo are efficacious in treating GVHD-associated dry eye disease and highlights miR-204 as a potential therapeutic agent.
other	35020440	hsa-mir-204	Dry Eye Syndromes	Blockade of miR-204 abolished the effects of MSC-exo, while overloading L929-exo with miR-204 markedly attenuated dry eye. Thus, this study suggests that MSC-exo are efficacious in treating GVHD-associated dry eye disease and highlights miR-204 as a potential therapeutic agent.
lncRNA target	35020000	hsa-mir-181c	Inflammation	CONCLUSION: Altogether, our data provide a novel function of miR-181c-5p in macrophage biology and suggest that targeting macrophage miR-181c-5p in injured tissues might improve clearance of dead cells and lead to efficient inflammation resolution.
target gene	35019376	hsa-mir-29b	Liver Neoplasms	LA-PLGA-Sil instigate the cell death of HepG2 cells via apoptosis by targeting the miR-29b/p53 axis through the stabilization of NFκB.
transcription factor target	35018773	hsa-mir-155	Myocardial Infarction	Finally, the target miR-155 in urine samples collected from MI rats was quantified and the level of miR-155 in MI groups was 30 times higher than in the control groups. The results suggest that urinary miR-155 could be a novel biomarker for the noninvasive diagnosis of MI.
lncRNA target	35018772	hsa-mir-21	Lung Neoplasms	In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS.
lncRNA target	35018772	hsa-mir-125b	Lung Neoplasms	In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS.
lncRNA target	35018772	hsa-mir-141	Lung Neoplasms	In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS.
other	35018758	hsa-mir-6717	Pituitary ACTH Hypersecretion	5p 4.49 (p=0,031).
other	35018758	hsa-mir-383	Pituitary ACTH Hypersecretion	5p 4.49 (p=0,031).
other	35018758	hsa-mir-1203	Pituitary ACTH Hypersecretion	5p 4.49 (p=0,031).
other	35018758	hsa-mir-4290	Pituitary ACTH Hypersecretion	5p 4.49 (p=0,031).
lncRNA target	35018737	hsa-let-7b	Obesity	Conclusion: Hepatocyte TGF-beta-let-7b-5p signaling promotes HFD-induced steatosis and obesity by reducing mitochondrial oxidative phosphorylation and suppressing white-to-beige fat conversion.
lncRNA target	35018737	hsa-let-7b	Non-alcoholic Fatty Liver Disease	Conclusion: Hepatocyte TGF-beta-let-7b-5p signaling promotes HFD-induced steatosis and obesity by reducing mitochondrial oxidative phosphorylation and suppressing white-to-beige fat conversion.
genetics_overexpression_promote	35018247	hsa-mir-148a	Stomach Neoplasms	Overexpression of miR-148a in GC cells inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition.
circulation_biomarker_prognosis_up	35018114	hsa-mir-185	Ischemic Stroke	CONCLUSION: There are two factors related to the up-regulated expression of serum miR-185 and miR-424, one is the severity degree of neurological impairment of patients with AIS and the other is their prognosis.
circulation_biomarker_prognosis_up	35018114	hsa-mir-424	Ischemic Stroke	CONCLUSION: There are two factors related to the up-regulated expression of serum miR-185 and miR-424, one is the severity degree of neurological impairment of patients with AIS and the other is their prognosis.
transcription factor target	35017523	hsa-mir-365	Short Qt Syndrome	Action potential recordings in patient-specific induced pluripotent stem cell-derived cardiac myocytes show that elevation of miR-365 significantly prolongs action potential duration in myocytes derived from a Short-QT syndrome patient, whereas specific inhibition of miR-365 normalizes pathologically prolonged action potential in Long-QT syndrome myocytes.
transcription factor target	35017523	hsa-mir-365	Short QT Syndrome 2	Action potential recordings in patient-specific induced pluripotent stem cell-derived cardiac myocytes show that elevation of miR-365 significantly prolongs action potential duration in myocytes derived from a Short-QT syndrome patient, whereas specific inhibition of miR-365 normalizes pathologically prolonged action potential in Long-QT syndrome myocytes.
lncRNA target	35017465	hsa-mir-326	Stomach Neoplasms	Further mechanistic investigation showed that FAM225A acted as a miR-326 sponge to upregulate its direct target PADI2 in GC. Overall, our findings indicated that FAM225A promoted GC development and progression via a competitive endogenous RNA network of FAM225A/miR-326/PADI2 in GC, providing insight into possible therapeutic targets and prognosis of GC.
lncRNA target	35017437	hsa-mir-455	Reperfusion Injury, Cerebral Ischemia	These results suggest that miR5p is a potential biomarker and therapeutic target for the treatment of cerebral ischemia/reperfusion injury and that it alleviates cerebral ischemia/reperfusion injury by inhibiting C-C chemokine receptor type 5 expression and reducing the neuroinflammatory response.
transcription factor target	35017014	hsa-mir-1	Hypertrophy	Based on our results, we conclude that G3bp1 through its regulation of mature miR-1 levels plays a critical role in regulating the expression of essential cardiac-enriched genes and those involved in development of cardiomyocyte hypertrophy.
transcription factor target	35017014	hsa-mir-1	Cardiomegaly	Based on our results, we conclude that G3bp1 through its regulation of mature miR-1 levels plays a critical role in regulating the expression of essential cardiac-enriched genes and those involved in development of cardiomyocyte hypertrophy.
other	35016888	hsa-mir-29a	Myocardial Infarction	CONCLUSION: Our study provides evidence that c-MYC binding to the promoter of miR-29a-3p to facilitate TET2 expression has therapeutic effect on ventricular remodeling of MI rats.
other	35016888	hsa-mir-29a	Infarction	Cardiac function, infarct size, cellular death, inflammatory response, oxidative stress, collagen deposition, c-MYC, TET2 and miR-29a-3p expression were analyzed. Up-regulating c-MYC or down-regulating miR-29a-3p in MI rat hearts improved cardiac function and reduced infarct size and myocardial apoptotic death, restrained oxidative stress, inflammatory response, attenuated collagen deposition.
lncRNA target	35016717	hsa-mir-423	Prostatic Neoplasms	5p, defined as a target with in silico prediction analysis, in PCa.
other	35016595	hsa-mir-130b	Uterine Cervical Neoplasms	CONCLUSION: miR-130b promoted the growth of cervical cancer cells during the exponential phase, whereas it impaired the survival of cells during stationary phases.
transcription factor target	35016493	hsa-mir-17	psoriasis 1	3p might be a novel therapeutic target for psoriasis.
circulation_biomarker_diagnosis_up	35016439	hsa-mir-21	Fibrosis, Atrial	The increasing levels of circulating miR-21 were significantly associated with the higher risk of AF by using logistic regression analysis, even after adjustment for known confounding variables.
circulation_biomarker_diagnosis_up	35016439	hsa-mir-21	Atrial Fibrillation	The increasing levels of circulating miR-21 were significantly associated with the higher risk of AF by using logistic regression analysis, even after adjustment for known confounding variables.
lncRNA target	35016264	hsa-mir-1270	Ovarian Neoplasms	From rescue experiments, HCG11 impeded AKT/mTOR pathway to retard ovarian cancer cell growth by miR-1270/PTEN. CONCLUSIONS: HCG11 was a tumor suppressor in ovarian cancer cells and additionally, HCG11 regulated AKT/mTOR pathway to hinder ovarian cancer cell growth via modulating miR-1270/PTEN, indicating that HCG11 may represent a promising target for effective treatment of ovarian cancer patients.
exosome	35015859	hsa-mir-140	Subarachnoid Hemorrhage	MSC-EV-delivered miR
exosome	35015859	hsa-mir-140	Brain Injuries	MSC-EV-delivered miR
genetics_GWAS	35015850	hsa-mir-223	Friedreich Ataxia	This study describes for the first time the association between hsa-miR223-3p and HAX-1 expression in FRDA, thus supporting a potential role of this microRNA as non-invasive epigenetic biomarker for FRDA.
lncRNA target	35015607	hsa-mir-423	Uterine Cervical Neoplasms	5p upregulation and LOXL1-AS1 downregulation inhibited CC cell proliferation and migration, while ENC1 upregulation attenuated the inhibitory effects of miR
lncRNA target	35015267	hsa-mir-1305	Carcinoma, Hepatocellular	Overall, these results demonstrate that downregulation of circ_0008934 repress HCC growth and metastasis by upregulating miR-1305 to inhibit TMTC3, suggesting circ_0008934/ miR-1305/ TMTC3 regulatory axis may be a possible novel therapeutic target for HCC.
circulation_biomarker_diagnosis_ns	35015112	hsa-mir-133a	Hyperglycemia	CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training.
circulation_biomarker_diagnosis_ns	35015112	hsa-mir-133b	Hyperglycemia	CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training.
circulation_biomarker_diagnosis_ns	35015112	hsa-mir-29a	Hyperglycemia	CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training.
circulation_biomarker_diagnosis_ns	35015112	hsa-mir-155	Hyperglycemia	CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training.
circulation_biomarker_diagnosis_ns	35015112	hsa-mir-29a	Diabetes Mellitus, Type 2	Eight weeks of combined exercise training do not alter circulating microRNAs-29a, PURPOSE: Individuals with a family history of type 2 diabetes (FH+) have an increased risk of developing type 2 diabetes.
genetics_knock down_suppress	35014985	hsa-mir-374a	Stroke	Knockdown of NEAT1 regulated OGD/R injury of CHME5 cells via miR374a5p/NFAT5 axis to induce the shifting of microglia from M1 to M2 and inhibit inflammatory response, making it a potential target for stroke treatment.
genetics_overexpression_suppress	35014946	hsa-mir-195	Colorectal Neoplasms	5p overexpression model was engineered in CRC cells, followed by treatment with DDP or the autophagy inhibitor (Chloroquine, CQ).
genetics_knock down_suppress	35014684	hsa-mir-134	Breast Neoplasms	Furthermore, the effect of a miR1343p inhibitor on BC progression was rescued by the knockdown of PITX2 in cells transfected with short hairpin RNAlncRNA PCAT1.
epigenetics	35014676	hsa-mir-181b	Colorectal Neoplasms	METTL3dependent m(6)A methylation promoted the miR181b5p process by DiGeorge Syndrome Critical Region 8 (DGCR8) in CAFs.
exosome	35014676	hsa-mir-181d	Colorectal Neoplasms	Furthermore, exosomal miR181d5p may represent a potential prognostic marker for CRC.
transcription factor target	35014672	hsa-mir-375	Hay-Wells syndrome	However, the detailed mechanisms responsible for the effects of miR375 on Dexinduced AEC dysfunction remain elusive. Thus, it was suggested that the downregulated expression of miR375 may be a therapeutic target for AEC dysfunction.
other	35014431	hsa-mir-27a	Breast Neoplasms	Additionally, the remarkable discrimination of single nucleotide difference suggested superior selectivity and was able to detect miRNA-27a extracted from breast cancer cells.
transcription factor target	35014213	hsa-mir-671	Pulmonary Fibrosis	Conclusion: We identify the negative regulation of miR5p on Angpt1 and VWF and liver fibrosis-associated angiogenesis, which may provide promising targets for the prevention and treatment of liver disease.
transcription factor target	35014213	hsa-mir-671	von Willebrand Diseases	Conclusion: We identify the negative regulation of miR5p on Angpt1 and VWF and liver fibrosis-associated angiogenesis, which may provide promising targets for the prevention and treatment of liver disease.
other	35014077	hsa-mir-375	Breast Neoplasms	Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients.
other	35014077	hsa-mir-142	Breast Neoplasms	Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients.
other	35014077	hsa-mir-34c	Breast Neoplasms	Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients.
other	35014054	hsa-mir-618	Heart Injuries	PRACTICAL APPLICATIONS: The findings outlined in the current study show that the antifibrotic function of TAN is closely related to the function of miRs: the induction of miR-618 is indispensable for the function of TAN against the fibrotic process after heart injury, which will promote the application of TAN as an adjuvant therapy for improving heart function.
transcription factor target	35014054	hsa-mir-618	Hypertrophy	TAN inhibits hypertrophy and collagen deposition in heart tissues, which is associated with the increased level of miR-618.
lncRNA target	35013925	hsa-mir-497	Pulmonary Fibrosis	5p-mediated suppression of CCL19 relieved HG-induced cell apoptosis, inflammation, and fibrosis in HK-2 cells.
lncRNA target	35013925	hsa-mir-497	Inflammation	5p-mediated suppression of CCL19 relieved HG-induced cell apoptosis, inflammation, and fibrosis in HK-2 cells.
transcription factor target	35013887	hsa-mir-200c	Nervous System Diseases	MiR-200c-3p/RIP2 might be a potential therapeutic target for the treatment of neuroinflammation-associated diseases.
lncRNA target	35013864	hsa-mir-142	Carcinoma, Hepatocellular	Our findings suggest that MELK/miR5p axis could be a potentially therapeutic target for reversing the sorafenib resistance in HCC treatment.
genetics_knock down_promote	35013754	hsa-mir-766	Carcinoma, Non-Small-Cell Lung	5p interacted with the 3' untranslated region (3'UTR) of FAM83A, and FAM83A overexpression largely reversed miR
circulation_biomarker_diagnosis_ns	35013528	hsa-mir-5739	Glioblastoma	CfmiR3p and cfmiR-5739 have potential utility in diagnosing patients with pGBM and rGBM tumors using a minimally invasive blood assay.
circulation_biomarker_diagnosis_ns	35013528	hsa-mir-3180	Glioblastoma	CfmiR3p and cfmiR-5739 have potential utility in diagnosing patients with pGBM and rGBM tumors using a minimally invasive blood assay.
circulation_biomarker_diagnosis_ns	35013491	hsa-mir-92a	Hypertension	Serum miR-92a level was higher in hypertensive patients than controls.
lncRNA target	35013157	hsa-mir-432	Glioma	In conclusion, circFOXM1 acts as a sponge of miR-432 to promote the proliferation and aggressiveness of glioma cells through the Galpha12 signalling pathway.
lncRNA target	35013144	hsa-mir-124	Carcinoma, Hepatocellular	3p.1-FOXO3a axis is implicated as a potential target for the diagnosis and treatment of HCC.
circulation_biomarker_diagnosis_down	35013132	hsa-mir-26a	Stomach Neoplasms	The level of miR-26a had negatively correlated with LINC00205 expression and was decreased among GC cell lines, tissues, and serum samples.
genetics_overexpression_suppress	35013115	hsa-mir-142	Nasopharyngeal Carcinoma	5p mimic-transfected NPC cells, followed by overexpression of HGF and EGF.
exosome	35013102	hsa-mir-499b	Carcinoma, Hepatocellular	These results indicate that exosome circRNAs secreted from RBPJ(+/+) Mphi inhibits tumor progression through the hsa_circ_0004658/miR-499b-5p/JAM3 pathway and hsa_circ_0004658 may be a diagnostic biomarker and potential target for HCC therapy.
circulation_biomarker_prognosis_up	35012923	hsa-mir-3682	Carcinoma, Hepatocellular	3p expression in the cytoplasm of HCC and adjacent tissues, and its expression was signifcantly up-regulated in HCC tissues (t=2.659, P=0.009).
circulation_biomarker_diagnosis_up	35012615	hsa-mir-3150b	Uterine Cervical Neoplasms	The cytoplasmic localization of LINC00885 was ascertained and furthermore, LINC00885 competitively bound with miR-3150b-3p to upregulate BAZ2A expression in CC cells.
genetics_knock down_promote	35012554	hsa-mir-7	Leukemia, Myeloid, Acute	5p, as well as in vitro and in vivo functional validation via gain- and loss-of-function methods.
genetics_knock down_promote	35012553	hsa-mir-326	Adenocarcinoma of Lung	MiR-326 was a target of circ_0020850, and knockdown of miR-326 abolished the suppression effect of circ_0020850 on the malignant behaviors of lung adenocarcinoma cells.
target gene	35012539	hsa-mir-133a	Ovarian Neoplasms	miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy.
genetics_overexpression_promote	35012518	hsa-mir-342	Nasopharyngeal Carcinoma	3p overexpression attenuated the effect of TP73-AS1 in NPC cells.
lncRNA target	35012442	hsa-mir-144	Brain Ischemia	Inhibition of lncRNA ZFAS1 improves functional recovery and angiogenesis after FCI via miR
lncRNA target	35012438	hsa-mir-137	Stomach Neoplasms	These findings disclosed that PURPL serves as an oncogene in the context of GC via miR
lncRNA target	35012431	hsa-mir-1224	Laryngeal Papilloma	Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR
lncRNA target	35012431	hsa-mir-577	Laryngeal Papilloma	Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR
genetics_knock down_suppress	35012421	hsa-mir-181a	Lissencephaly	Rescue experiments showed that miR-181a-5p overexpression or ERG knockdown could reverse the inhibitory effects of circ_0020093 overexpression on the pathological changes in IL-1beta-induced C28/I2 cells. Circ_0020093 overexpression alleviated IL-1beta-induced human chondrocyte inflammatory injury, apoptosis and ECM degradation by targeting miR-181a-5p/ERG pathway.
other	35011745	hsa-mir-191	Myocardial Infarction	5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI.
other	35011745	hsa-mir-26a	Myocardial Infarction	5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI.
other	35011745	hsa-mir-134	Myocardial Infarction	5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI.
lncRNA target	35011699	hsa-mir-155	Alzheimer Disease	Candidate downregulated target genes by cortical miR-155 included Foxo3, Runx2 and CEBPbeta at 3 months and Foxo3, Runx2 and Socs1 at 9 months, which are implicated in cell survival, but also in Abeta pathology and microglia/astrocyte dysfunction.
other	35011660	hsa-mir-613	Coronary Artery Disease	3p.
other	35011660	hsa-mir-200a	Coronary Artery Disease	3p.
lncRNA target	35011620	hsa-mir-511	Colitis	Together, this study shows that miR-511 is involved in the regulation of intestinal inflammation through downstream regulation of TLR3 and TLR4 responses via Wdfy1.
other	35011587	hsa-mir-200a	Adenocarcinoma of Lung	The analysis of the multi-gene regulation model indicated that the WT1-AS (downregulation)-miR-200a-3p (upregulation)-IGF2BP2 (downregulation) pattern significantly improved the survival of LUAD patients.
transcription factor target	35011574	hsa-mir-140	Breast Neoplasms	Collectively, the above results demonstrate the importance of the Nrf2/HO-1 axis in cancer progression and, thus, targeting Nrf2 by miR5p could be a better strategy for the treatment of Nrf2-driven breast cancer progression.
other	35008894	hsa-mir-938	Stomach Neoplasms	Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage.
other	35008894	hsa-mir-3175	Stomach Neoplasms	Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage.
other	35008894	hsa-mir-548j	Stomach Neoplasms	Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage.
other	35008894	hsa-mir-4274	Stomach Neoplasms	Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage.
lncRNA target	35008854	hsa-mir-29a	Diabetes Mellitus, Type 2	Thus, inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling.
lncRNA target	35008854	hsa-mir-29a	Peripheral Arterial Disease	Thus, inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling.
genetics_GWAS	35008806	hsa-mir-423	Breast Neoplasms	We propose that the rs6505162-A allele promotes miR-423 overexpression, and that the rs6505162-A allele induces BC cell proliferation, viability, chemoresistance, migration, and invasion, and decreases cell apoptosis as a consequence.
other	35008751	hsa-mir-194	Breast Neoplasms	5p functions as a tumor biomarker in breast cancer, providing new insights for the study of breast cancer development and metastasis.
other	35008652	hsa-mir-494	Colorectal Neoplasms	Analysis of human colorectal cancer tissue revealed that miR-494 was present at low levels in non-metastatic cases and cases with simultaneous liver metastases but was expressed at high levels in cases with delayed liver metastases, which also exhibited reduced expression of PGC1alpha and MYCC.
circulation_biomarker_prognosis_ns	35008626	hsa-mir-150	Lymphoma, Non-Hodgkin	5p/MALAT1 and hsa-miR335-5p/NEAT1 pairs' plasma levels were remarkably associated with NHL patients' prognosis, being independent prognostic factors in a multivariate Cox analysis.
circulation_biomarker_prognosis_ns	35008626	hsa-mir-335	Lymphoma, Non-Hodgkin	5p/MALAT1 and hsa-miR335-5p/NEAT1 pairs' plasma levels were remarkably associated with NHL patients' prognosis, being independent prognostic factors in a multivariate Cox analysis.
circulation_biomarker_diagnosis_down	35008579	hsa-mir-199a	Graves Disease	Interestingly, GD thyroids, GD plasmas and GO orbital fats showed a downregulation of miR-199a-3p/-5p.
other	35008529	hsa-mir-205	Carcinoma, Ductal, Breast	CONCLUSIONS: miR5p and potentially ZEB1 gene are promising candidates for markers of metastatic potential in ductal BC.
lncRNA target	35008480	hsa-mir-630	Carcinoma, Embryonal	Experimentally, we showed that transfection of MIR630 mimic into embryonal carcinoma cell lines directly targeted the 3'UTR of OCT4, SOX2, and NANOG and markedly suppressed their expression.
lncRNA target	35008442	hsa-mir-216a	nonpapillary renal cell carcinoma	Taken together, these results provide the first evidence that lucanthone enhances TRAIL-induced apoptosis through DR5 upregulation by downregulation of miR-216a-5p and DUB3-dependent Mcl-1 downregulation in human renal carcinoma cells.
circulation_biomarker_diagnosis_ns	35008424	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	Therefore, miR-3182 provides potential to be used for the detection of NSCLC in blood samples, which could result in earlier therapy and thus improved outcomes and survival for patients.
other	35008302	hsa-let-7	Medulloblastoma	Altogether, our results suggest that let-7 activity and MYCN can further categorize heterogeneous SHH tumors into more and less-favorable prognostic subtypes, which provide critical information for personalizing treatment options for SHH-MB.
tissue_expression_up	35007926	hsa-mir-187	Abortion, Habitual	We found that the expression of miR-187 in villi of RM group was higher than that of normal abortion group and miR-187 inhibited the proliferation, migration, and invasion of HTR8 cells.
therapeutic target	35007850	hsa-mir-365	Stomach Neoplasms	Furthermore, Metformin and miR-365 synergistically promote the apoptosis of gastric cancer cells by miR-365-PTEN-AMPK axis.
target gene	35007826	hsa-mir-139	Osteosarcoma	We found that the expression of miR-139 in osteosarcoma tissue was significantly reduced, while the expression of ITGAV was significantly increased. MiR-139 could specifically bind to the 3'-UTR of ITGAV and negatively regulate its expression.
lncRNA target	35007433	hsa-mir-17	Urinary Bladder Neoplasms	5p was shown to be a direct target of HAND2-AS1, and it reversed the inhibitory effect of HAND2-AS1 on BC malignancies.
exosome	35006577	hsa-mir-148a	Liver Cirrhosis	Bioinformatics analysis revealed miR-148a-5p as a regulator in liver fibrosis. Extracellular vesicles from miR-148a-5p enriched BMSCs attenuated hepatic fibrosis in liver fibrosis by targeting Smad4.
genetics_knock down_suppress	35006556	hsa-mir-142	Sleep Apnea, Obstructive	3p alleviated damage induced by MALAT1 knockdown in IH-treated HUVECs.
other	35005988	hsa-mir-218	Urinary Bladder Neoplasms	5p-CCNE2/SMC4 signal axis may be involved in the invasion process of bladder cancer.
transcription factor target	35005951	hsa-mir-122	Radiation Injuries	It was demonstrated that the drug-induced hepatic inflammation could also be assessed via detecting miR-122 using this SERS method.
transcription factor target	35005951	hsa-mir-122	Hepatitis	It was demonstrated that the drug-induced hepatic inflammation could also be assessed via detecting miR-122 using this SERS method.
tissue_expression_up	35005835	hsa-mir-214	Rhinitis, Allergic	We found that miR-214-3p was overexpressed in macrophages and nasal mucus tissues from AR patients.
circulation_biomarker_diagnosis_down	35005769	hsa-mir-24	acute myocardial infarction	We demonstrated that in acute myocardial infarction (AMI) patient blood samples, the expression of miR-24-3p is down-regulated, the expression of IL-1beta or NKAP is up-regulated, and IL-1beta or NKAP is negatively correlated with miR-24-3p.
other	35005549	hsa-mir-29c	Osteoporosis	ROC analysis shows miR-29cb2 in PB has higher sensitivity and specificity for diagnosing osteoporosis when compared with four clinical biomarkers.
other	35005241	hsa-mir-143	Instent Restenosis	The purpose of this study is to observe the potential value and underlying mechanism of the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-143 axis in ISR. MALAT1 is highly expressed in patients with ISR while miR-143 is decreased, and the MALAT1/miR-143 axis is a potential pathway to modulate the multiplication and invasiveness of HVSMCs.
circulation_biomarker_diagnosis_ns	35005155	hsa-mir-200c	Ovarian Neoplasms, High-Grade Serous	Transcriptomic analysis of patient plasma reveals circulating miR200c as a BACKGROUND: High-grade serous tubo-ovarian cancer (HGSC) is the most common histological subtype of epithelial ovarian cancer, and highly lethal. Further larger cohort studies exploring earlier stages are needed to determine whether circulating miR200c may be a sensitive and specific biomarker of tubo-ovarian cancer.
lncRNA target	35005034	hsa-mir-4679	Colorectal Neoplasms	We then found that hsa-miR-4679 could bind to lncRNA CCAT1 directly, and with further functional analyses, we confirmed that lncRNA CCAT1 sponged hsa-miR-4679 to promote the progression of colorectal cancer.
lncRNA target	35005012	hsa-mir-10b	Carcinoma, Hepatocellular	CONCLUSIONS: miR-10b-5p reduced HCC cell proliferation but accelerate apoptosis by regulating EphA2, suggesting it has the potential to be a clinical target for HCC.
other	35004677	hsa-mir-20a	Carcinoma, Renal Cell	Collectively, HIF-1alpha mediated HECTD2 up-regulation and aggravated RCC progression by attenuating miR-320a.
other	35004351	hsa-mir-25	Rabies	Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy.
other	35004351	hsa-mir-218	Rabies	Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy.
other	35004351	hsa-mir-598	Rabies	Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy.
other	35004351	hsa-mir-26b	Rabies	Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy.
other	35004326	hsa-mir-877	Glioblastoma	Our results collectively indicate that circPIK3C2A functions as ceRNA by mediating miR5p/FOXM1 axis, providing a novel perspective of applying CircPIK3C2A in the clinical intervention of glioblastoma in the future.
other	35004298	hsa-mir-34c	Triple Negative Breast Neoplasms	Moreover, we found METTL3 is repressed by miR-34c-3p in TNBC cells.
lncRNA target	35004274	hsa-mir-429	Carcinoma, Ovarian Epithelial	In conclusion, our study validated that EPDR1, negatively regulated by miR-429, played an important role as a tumor-suppressor gene in EOC development via inhibition of the PI3K/AKT pathway. The miR-429/EPDR1 axis might provide novel therapeutic targets for individualized treatment of EOC patients in the future.
target gene	35004266	hsa-mir-526b	Breast Neoplasms	MiR-526b-3p Attenuates Breast Cancer Stem Cell Properties and Chemoresistance by Targeting HIF-2α/Notch Signaling.
transcription factor target	35004265	hsa-mir-148b	Carcinoma, Hepatocellular	DTYMK is a key regulator of HCC progression, and its expression is suppressed by miR-148b-3p, suggesting that this miR-148b-3p/DTYMK regulatory axis may be amenable to therapeutic targeting in patients with HCC.
lncRNA target	35004257	hsa-mir-940	Adenocarcinoma of Lung	CONCLUSIONS: The present study showed that miR-940 might be a protective factor for positive prognosis in early stage nonsmoking female lung adenocarcinoma, with transforming growth factor-beta (TGF-beta) pathway, TNF pathway, and matrix metalloprotein (MMP9) being potential targets.
target gene	35004133	hsa-mir-137	Non-alcoholic Fatty Liver Disease	Mechanistically, we revealed that miR-137-3p is directly bound to the 3'-untranslated region of PDE4D and subsequently increased hepatic cAMP level and protein kinase A activity, thereby activating the downstream AMPKalpha pathway.
other	35003737	hsa-mir-186	Colorectal Neoplasms	The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population.
other	35003737	hsa-mir-1	Colorectal Neoplasms	The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. These data suggested that miR-31 and miR-145, upon further clinical validation, may be used as potential diagnostic biomarkers for the early detection of CRC at the polyp stage.
other	35003737	hsa-mir-145	Colorectal Neoplasms	The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. These data suggested that miR-31 and miR-145, upon further clinical validation, may be used as potential diagnostic biomarkers for the early detection of CRC at the polyp stage.
other	35003737	hsa-mir-146b	Colorectal Neoplasms	The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population.
genetics_overexpression_promote	35003396	hsa-mir-372	Esophageal Neoplasms	Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells.
genetics_overexpression_promote	35003396	hsa-mir-372	Thyroid Cancer, Papillary	Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells.
genetics_knock down_suppress	35003317	hsa-mir-603	skin melanoma	The results of the rescue experiment demonstrated that inhibiting microRNA-603 expression could suppress the proliferation, migration, and invasion of cutaneous melanoma cells, but its suppressive effect could be restored by TBX5.
lncRNA target	35003309	hsa-mir-15	Carcinoma, Non-Small-Cell Lung	5p expression in NSCLC cells and that NKD1, AXIN2, and WIF1 are the target genes of miR
lncRNA target	35003259	hsa-mir-370	Prostatic Neoplasms	3p could target P21(CIP1) in PCa cells.
genetics_overexpression_promote	35003111	hsa-mir-511	Arteritis	Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries.
genetics_overexpression_promote	35003111	hsa-mir-142	Arteritis	Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries.
genetics_overexpression_promote	35003111	hsa-mir-155	Arteritis	Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries.
genetics_overexpression_promote	35003111	hsa-mir-132	Arteritis	Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries.
genetics_overexpression_promote	35003111	hsa-mir-212	Arteritis	Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries.
tissue_expression_down	35002969	hsa-let-7e	Muscular Atrophy	The serum let-7e-5p levels were significantly lower, which might be in compensation, in subjects with decreased muscle mass compared to subjects without decreased muscle mass.
lncRNA target	35002727	hsa-mir-4640	Thyroid Cancer, Papillary	Our findings confirmed for the first time that AhR antagonists promote differentiation of PTC via inhibiting the circSH2B3/miR5p/IGF2BP2 axis, offering a novel therapeutic approach and a potential marker for differentiation of PTC.
circRNA target	35002529	hsa-mir-938	Glioma	An evaluation of the underlying mechanism revealed that circCDK14 sponged miR-3938 to upregulate oncogenic gene PDGFRA expression.
tissue_expression_up	35002516	hsa-mir-125a	Pulmonary Disease, Chronic Obstructive	beta-Galactose staining showed that the lung tissues of smokers have a higher degree of cellular senescence, and the expression of miR-125a-5p is high.
tissue_expression_up	35002514	hsa-mir-106b	Carcinoma, Hepatocellular	The expression of circCCNB1 and GPM6A were significantly down-regulated in HCC cells and cancer tissues, while miR-106b-5p expression was up-regulated.
genetics_knock down_promote	35002378	hsa-mir-23a	Femur Head Necrosis	In addition, icariin treatment/miR-23a knockdown increased bone biochemical markers (ACP-5, BAP, NTXI, CTXI and OC) and improved ONFH in ONFH model rats.
genetics_knock down_suppress	35002322	hsa-mir-636	Nasopharyngeal Carcinoma	miR-636 overexpression or TPD52 knockdown weakened the promoting effect of Hsa_circ_0007637 on NPC cells malignant phenotype (P < 0.01).
other	35002277	hsa-mir-378a	Inflammatory Bowel Diseases	CONCLUSION: Two miRNAs (hsa-miR5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers.
other	35002277	hsa-mir-141	Inflammatory Bowel Diseases	CONCLUSION: Two miRNAs (hsa-miR5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers.
genetics_overexpression_suppress	35001875	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	Overexpression of miR-145 decreased cell proliferation, induced apoptosis, and suppressed migration and invasion in lung cancer. Additionally, miR-145 co-transfection abolished the oncogenic role of hsa_circ_0003288.
circRNA target	35001739	hsa-mir-335	Lymphoma, Large B-Cell, Diffuse	MiR-335-5p could be sponged by circ_0003645, and NFIB was confirmed to be a downstream target of miR-335-5p.
tissue_expression_up	35001683	hsa-mir-451a	Pancreatic Neoplasms	The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals.
genetics_knock down_suppress	35001328	hsa-mir-23a	Cerebral Infarction	However, the improvement of BMSCs-exo to CI was reversed by miR-23a-3p knockdown.
target gene	35000595	hsa-mir-526b	Carcinoma, Non-Small-Cell Lung	we verified that OSBPL5 was a downstream target of miR-526b-3p and long noncoding RNA (lncRNA) LMCD1-AS1 served as a sponge for miR-526b-3p.
target gene	35000531	hsa-mir-128	Stomach Neoplasms	All over these results showed lncRNA CCL2 played importance of role in gastric tumor via miR-128/PARP2 axis signal pathway.
circRNA target	35000524	hsa-mir-203	Urinary Bladder Neck Obstruction	The circPVT1 and suppressor of cytokine signaling 3 (SOCS3) expression levels were upregulated (p = 0.0061 and 0.0328, respectively), whereas the microRNA-203a (miR-203) level was downregulated in rats with bladder remodeling (p=0.0085).
genetics_overexpression_suppress	35000421	hsa-mir-150	Heart Failure	Importantly, miR-150 overexpression attenuates the detrimental post-MI effects caused by MIAT.
other	35000391	hsa-let-7a	Lung Neoplasms	Moreover, this method can accurately quantify let-7a expression at a single-cell level and can even distinguish the let-7a expression between non-small cell lung cancer patient tissues and healthy person tissues.
target gene	35000195	hsa-mir-591	Glioma	CircABCC1 functions as an oncogene to promote the progression of glioma via the regulation of miR-591/HMGA2 signaling.
genetics_overexpression_suppress	35000146	hsa-mir-192	Endometrial Neoplasms	Importantly, we indicated that miR-192-5p-overexpressed TAMs-derived exosomes regulated the EC cells apoptosis and EMT through inhibiting IRAK1/NF-kappaB signaling pathway.
tissue_expression_down	35000027	hsa-mir-556	Breast Neoplasms	miR-556-5p was downregulated in breast cancer samples according to online datasets and experimental analyses.
target gene	34999395	hsa-mir-185	Neuralgia	this study suggested that miR-185-5p chokes CCI-induced NP and neuroinflammation by targeting MyD88 and CXCR4
target gene	34999393	hsa-mir-181a	Pneumonia	Mechanistically, PRP had the similar effects as miR-181a-5p antagomir on RSV-induced apoptosis and inflammation in HEp-2 cells via upregulating BCL2, MLL3 and SIRT1, which could be reversed by miR-181a-5p mimic.
target gene	34999254	hsa-mir-34a	Cholangiocarcinoma	miR-34a-5p directly targeted WNT7B and inhibited WNT7B expression.
lncRNA target	34999183	hsa-mir-141	Neuralgia	miR-141 was reduced in CCI rats and restored by the lncRNA H19 knockdown, suggesting the potential negative associations of miR-141 with lncRNA H19.
tissue_expression_down	34999004	hsa-mir-200c	COVID-19	At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced.
tissue_expression_down	34999004	hsa-mir-421	COVID-19	At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced.
circulation_biomarker_prognosis_down	34998954	hsa-mir-485	Neuroblastoma	These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome.
circulation_biomarker_prognosis_down	34998954	hsa-mir-380	Neuroblastoma	These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome.
circulation_biomarker_prognosis_down	34998954	hsa-mir-99b	Neuroblastoma	These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome.
transcription factor target	34998813	hsa-mir-122	Fibrosis, Renal	Pharmacological inhibition of miR5p has potential therapeutic significance for hypertensive renal injury and fibrosis-related kidney diseases.
circulation_biomarker_prognosis_ns	34998434	hsa-let-7e	Nasopharyngeal Carcinoma	This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients.
circulation_biomarker_prognosis_ns	34998434	hsa-mir-647	Nasopharyngeal Carcinoma	This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients.
circulation_biomarker_prognosis_ns	34998434	hsa-mir-93	Nasopharyngeal Carcinoma	This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients.
circulation_biomarker_prognosis_ns	34998434	hsa-mir-26a	Nasopharyngeal Carcinoma	This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients.
epigenetics	34998421	hsa-mir-2355	Uterine Cervical Neoplasms	H3K27ac-activated EGFR-AS1 sponged miR-2355-5p and promoted CC cell growth through ACTN4-mediated WNT pathway.
genetics_overexpression_suppress	34998382	hsa-mir-615	Colorectal Neoplasms	Overexpression of miR-615 suppressed the growth of CRC cells.
target gene	34997970	hsa-mir-6755	Carcinoma, Hepatocellular	In summary, LINC00924 increases NDRG2 expression to inhibit EMT by targeting miR-6755-5p in HBV-related HCC.
genetics_knock down_promote	34997887	hsa-mir-23b	Inflammation	Also, Sema3A overexpression reversed the effects of miR-23b-3p mimic on inflammation, proliferation, and apoptosis of HG-induced podocytes.
circulation_biomarker_diagnosis_ns	34997773	hsa-mir-21	Constriction, Pathologic	CONCLUSION: Circulating lnc-GAS5 and its target miR-21 exhibit potency to serve as biomarkers for CHD management.
circulation_biomarker_diagnosis_ns	34997773	hsa-mir-21	Coronary Disease	CONCLUSION: Circulating lnc-GAS5 and its target miR-21 exhibit potency to serve as biomarkers for CHD management.
transcription factor target	34997725	hsa-mir-25	Glioma	Together, our data demonstrated that in glioma, miR3p may inhibit cancer cell growth through the suppression of FOXM1 and could be a promising new target for treating this type of brain cancer.
other	34997455	hsa-mir-626	Aortic Aneurysm, Abdominal	This research was performed for the functional analysis of circ_0092291 and its mechanism exploration with mircoRNA-626 (miR-626) and collagen type IV alpha1 chain (COL4A1) in AAA.
circulation_biomarker_diagnosis_up	34997188	hsa-mir-181a	Leigh Disease	In brief, MMP-9 was negatively correlated with miR-181a-5p in serum and placenta of SPE patients.
circulation_biomarker_diagnosis_ns	34997188	hsa-mir-181a	Pre-Eclampsia	MMP-9 and miR-181a-5p in serum and placenta are associated with adverse outcomes This study explored the correlation of MMP-9 with miR-181a-5p in severe preeclampsia (SPE).
other	34997082	hsa-mir-29b	Peritoneal Neoplasms	The miR-29b family is downregulated in peritoneal fluids in patients with peritoneal metastases (PM).
transcription factor target	34997082	hsa-mir-29b	Polymyalgia Rheumatica	MiR-29b inhibits TGF-beta1 induced MMT and replacement of miR-29b in the peritoneal cavity might be effective to prevent development of PM partly through the effects on MC.
genetics_GWAS	34996981	hsa-mir-218	Stress Disorders, Traumatic	Collectively, these findings establish the role of miR5p in chronic stress and the epigenetic function it plays to induce chromatin-based transcriptional changes of several CNS genes in triggering stress-induced disorders, including depression.
genetics_GWAS	34996981	hsa-mir-218	Neurotic Disorders	5p in chronic stress and the epigenetic function it plays to induce chromatin-based transcriptional changes of several CNS genes in triggering stress-induced disorders, including depression.
genetics_overexpression_promote	34996511	hsa-mir-205	Hepatoblastoma	RESULTS: MIR205HG was significantly overexpressed in HB.
lncRNA target	34996049	hsa-mir-135b	Femur Head Necrosis	Taken together, this study indicates that ESWT relieves endothelial injury and dysfunction in steroid-induced ONFH via miR-135b targeting FOXO1.
other	34995020	hsa-mir-135b	Inflammation	In conclusion, the miR-135b/183-FOXO1/TXNIP/NLRP3 inflammasome axis might be a novel mechanism for Se to antagonize HgCl(2) -induced oxidative stress and inflammation in the central immune organs of chickens.
lncRNA target	34995020	hsa-mir-135b	Thymus Neoplasms	Most importantly, Se effectively attenuated the aforementioned damage in the thymus and BF caused by HgCl(2) and inhibited the TXNIP/NLRP3 inflammasome pathway by reversing the expression of FOXO1 through inhibiting miR-135b/183.
lncRNA target	34995020	hsa-mir-135b	Behcet Syndrome	Most importantly, Se effectively attenuated the aforementioned damage in the thymus and BF caused by HgCl(2) and inhibited the TXNIP/NLRP3 inflammasome pathway by reversing the expression of FOXO1 through inhibiting miR-135b/183.
other	34994989	hsa-mir-497	Colorectal Neoplasms	PURPOSE: To investigate the BCL2/miRNA-497 expression ratio in colorectal cancer (CRC) and explore its association with the clinicopathological characteristics and CRC prognosis. CONCLUSION: The BCL2/miR497 expression ratio is associated with poor CRC prognosis in terms of metastasis and short survival.
genetics_overexpression_promote	34994952	hsa-mir-182	Urinary Bladder Neoplasms	CRIM1 genes and miR-182 in UMUC3 cell lines were overexpressed and silenced, respectively, to investigate their effects on invasion and migration of bladder cancer, and to detect the changes of miR182/Foxo3a expression.
lncRNA target	34993814	hsa-mir-34a	Breast Neoplasms	Up-regulation of KCNQ1OT1 was shown to inhibit miR-34a which was associated with blocking the inhibitory effect of miR-34a on BC cell proliferation, migration and invasion.
genetics_overexpression_promote	34993725	hsa-mir-451a	Breast Neoplasms	U6 snRNA was remarkably overexpressed in all the validations, miR-548b-5p levels were generally elevated and miR-451a expression was mostly downregulated in breast cancer groups. CONCLUSIONS: Our results indicated that U6 snRNA and miR-548b-5p may have pro-oncogenic functions, while miR-451a may act as tumor suppressor in breast cancer.
genetics_overexpression_promote	34993725	hsa-mir-548b	Breast Neoplasms	U6 snRNA was remarkably overexpressed in all the validations, miR-548b-5p levels were generally elevated and miR-451a expression was mostly downregulated in breast cancer groups. CONCLUSIONS: Our results indicated that U6 snRNA and miR-548b-5p may have pro-oncogenic functions, while miR-451a may act as tumor suppressor in breast cancer.
genetics_knock down_promote	34993722	hsa-mir-30	Prostatic Neoplasms	5p expression, and circ_0044516 knockdown suppressed PCa cell proliferation, migration, invasion, and cycle progression by enriching miR
other	34993348	hsa-mir-363	Carcinoma, Non-Small-Cell Lung	Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4.
genetics_overexpression_suppress	34993211	hsa-mir-145a	Diabetes Mellitus	In conclusion, our findings suggest that rectifying macrophage function using miR-145a-5p overexpression accelerates diabetic chronic wound healing.
other	34993023	hsa-mir-200c	Colorectal Neoplasms	CONCLUSION: We constructed a ceRNA network of ERCC4 in CRC, of which the MALAT1-miR-200c-3p-ERCC4 axis may be involved in the development, prognosis and chemotherapy sensitivity of CRC.
other	34992689	hsa-mir-1182	Prostatic Neoplasms	Mechanistic experiments showed that LINC01207 promoted carcinogenesis by sponging miR-1182 to regulate the protein levels of AKT3 in PC cell lines.
target gene	34992681	hsa-mir-21	Stomach Neoplasms	GAS8-AS1 acts as a tumor suppressor in gastric cancer, and it may inhibit cancer cell proliferation by downregulating miR-21-3p.
genetics_overexpression_promote	34992672	hsa-mir-130a	Carcinoma, Hepatocellular	The ectopic overexpression of PTP4A2 promoted hepatoma cell proliferation in vitro, which could be reversed by miRNA-130a-5p.
genetics_GWAS	34992522	hsa-mir-124	Depressive Disorder, Major	The aim of this study was to clarify the role of miR-124 methylation in MDD and antidepressant effects from the perspective of epigenetics.
genetics_GWAS	34992522	hsa-mir-124-1	Depressive Disorder, Major	The aim of this study was to clarify the role of miR-124 methylation in MDD and antidepressant effects from the perspective of epigenetics.
other	34992508	hsa-mir-20a	Alzheimer Disease	We performed differential expression analysis, coexpression analysis, enrichment analysis, and hypergeometric tests to calculate the underlying regulatory effects of multifactors on the modules by the way of the whole gene expression profile of AD and identify a series of ncRNA (miR-320a) and TF (NFKB1).
lncRNA target	34992498	hsa-mir-766	psoriasis 1	3p expression levels and inhibiting activation of S1PR3 through the AKT/mTOR pathway in psoriasis.
other	34992456	hsa-mir-17	uterine corpus endometrial carcinoma	3p in UCEC.
other	34992456	hsa-mir-381	uterine corpus endometrial carcinoma	3p in UCEC.
other	34992456	hsa-mir-93	uterine corpus endometrial carcinoma	3p in UCEC.
lncRNA target	34992034	hsa-mir-518f	Fetal Growth Retardation	5p and miR-518f-5p) expression with maternal, placental and newborn parameters and with their potential angiogenesis-associated target genes ENG, VEGF and FLT in a set of 68 small- (SGA, n = 30) and appropriate- (AGA, n = 38) for gestational age full-term singleton pregnancies, in relation to fetal sex.
transcription factor target	34992034	hsa-mir-517	Fetal Growth Retardation	CONCLUSION: We conclude that placental miR5p could be playing a key role in the pathophysiology of fetal growth restriction, which can be potentially targeted through maternal lifestyle modifications for improving fetoplacental growth.
lncRNA target	34991683	hsa-mir-577	Squamous Cell Carcinoma of Head and Neck	MiR-577 was found in OSCC with low expression, and RIP assays illustrated that NORAD, miR-577 and TPM4 coexisted in RNA-induced silencing complexes. CONCLUSIONS: It was revealed that NORAD functioned as a tumor promoter to sponge miR-577 thus elevating TPM4 in OSCC, which indicated that NORAD was worthy to be studied as a target for the treatment of OSCC.
other	34991629	hsa-mir-210	Stroke	RESULTS: Here, we measured miR expression levels in astrocytes around human ischemic stroke lesions and observed differential expression of miR-210 in chronic stroke astrocytes compared to astrocytes from neurological control tissue.
other	34991629	hsa-mir-210	Ischemic Stroke	RESULTS: Here, we measured miR expression levels in astrocytes around human ischemic stroke lesions and observed differential expression of miR-210 in chronic stroke astrocytes compared to astrocytes from neurological control tissue. CONCLUSIONS: We conclude that miR-210 expression in human astrocytes is modulated in response to ischemic stroke disease and under in vitro stress conditions, supporting a role for miR-210 in the astrocytic response to disease conditions.
other	34991609	hsa-mir-139	Carcinoma, Hepatocellular	The SNHG3 and THUMPD3-AS1/hsa-miR5p-SLC52A2 axis were identified as potential regulatory pathways in hepatocellular carcinoma.
lncRNA target	34991445	hsa-mir-365a	Osteosarcoma	Function experiments showed the effects of HCG18 and miR-365a-3p on OS cell growth. CONCLUSION: HCG18 promoted OS cell proliferation via enhancing aerobic glycolysis by regulating the miR-365a-3p/PGK1 axis.
epigenetics	34990753	hsa-mir-20a	Ovarian Neoplasms	Through rescue experiments, we certified that miR-20a-5p inhibits the autophagy and cisplatin resistance in OvCa via DNMT3B-mediated DNA methylation of RBP1.
lncRNA target	34990740	hsa-mir-181a	Thyroid Neoplasms	These data illustrated that ZNF674-AS1 alleviated TC progression by modulating the miR-181a/SOCS4 axis (graphical abstract), further suggesting that ZNF674-AS1 might be used as a therapheutic target in TC treatment.
other	34990478	hsa-mir-34a	Neonatal Sepsis	Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis. CONCLUSION: miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.
other	34990478	hsa-mir-199a	Neonatal Sepsis	Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis. CONCLUSION: miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment.
genetics_overexpression_promote	34990303	hsa-mir-128	Osteoarthritis	3p overexpression on OA progression.
other	34989810	hsa-mir-137	Neurotic Disorders	Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137.
other	34989810	hsa-mir-137	Schizophrenia	Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137.
other	34989810	hsa-mir-137	Cognition Disorders	Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137.
other	34989810	hsa-mir-137	Phobic Disorders	Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137.
other	34989810	hsa-mir-137	Anhedonia	Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137.
other	34989596	hsa-mir-221	Liver Diseases	3p).
other	34989596	hsa-mir-20a	Liver Diseases	3p).
other	34989596	hsa-mir-99a	Liver Diseases	3p).
other	34989596	hsa-mir-17	Liver Diseases	3p).
other	34989596	hsa-mir-197	Liver Diseases	3p).
other	34989596	hsa-mir-122	Liver Diseases	3p).
other	34989596	hsa-let-7d	Liver Diseases	3p).
genetics_GWAS	34989332	hsa-mir-218-2	Uterine Cervical Neoplasms	CONCLUSION: Our study suggests that the rs11134527 polymorphism in the miR
lncRNA target	34989314	hsa-mir-511	Retinoblastoma	3p reversed the negative effects of silencing ZFPM2-AS1 and PAX6 on retinoblastoma cell viability and migration.
lncRNA target	34989308	hsa-mir-144	Schizophrenia	3p might be associated with schizophrenia through down-regulating ATP1B2, implicating new targets of schizophrenia treatment.
other	34989253	hsa-mir-124	Atherosclerosis	Conclusion: MIAT/miR-124 axis mediated the effect of curcumin on atherosclerosis and altered cell apoptosis and proliferation, both in vivo and in vitro.
lncRNA target	34989145	hsa-mir-493	Carcinoma, Non-Small-Cell Lung	3p to increase RAB22A expression, which also offered an underlying targeted therapy for NSCLC treatment.
transcription factor target	34989130	hsa-mir-130	Pulmonary Arterial Hypertension	In this study, using miRNA sequencing and real-time PCR, we found that FGF21 treatment inhibited miR-130 elevation in hypoxia-induced PAH in vitro and in vivo. In conclusion, this study revealed the protective effect and mechanism of FGF21 on PAH through regulation of the miR-130/PPARgamma axis, providing new ideas for the development of potential drugs for PAH based on FGF21.
genetics_overexpression_promote	34989110	hsa-mir-599	Breast Neoplasms	MiR-599 interacted with the 3' untranslated region (3'UTR) of E2F3, and miR-599 overexpression-induced suppressive effect on cellular malignant potential was overturned by the accumulation of E2F3 in BC cells.
lncRNA target	34988853	hsa-mir-502	Leukemia, Myeloid, Acute	5p, and IGF1R might form a regulatory axis to affect the carcinogenicity of AML cells and provide potential targets for the treatment of AML.
exosome	34988777	hsa-mir-370	Carcinoma, Non-Small-Cell Lung	3p was downregulated in NSCLC tissues, cells and the exosomes from NSCLC cells compared with respective controls.
other	34988755	hsa-mir-125b	Nasal Polyps	miR-125b expression was significantly upregulated in NP tissues from patients with CRSwNP.
other	34988755	hsa-mir-125b	Inflammation	miR-125b expression was significantly upregulated in NP tissues from patients with CRSwNP.
lncRNA target	34988230	hsa-mir-455	Carcinoma, Hepatocellular	In conclusion, HOXA-AS3 modulated the functions of HCC cells through the miR5p/PD-L1 axis.
circulation_biomarker_diagnosis_down	34988221	hsa-mir-101	Carcinoma, Hepatocellular	CONCLUSION: The exosomal miR-101 and miR-125b panel in the serum may act as a noninvasive biomarker for HCC detection.
circulation_biomarker_diagnosis_down	34988221	hsa-mir-125b	Carcinoma, Hepatocellular	CONCLUSION: The exosomal miR-101 and miR-125b panel in the serum may act as a noninvasive biomarker for HCC detection.
lncRNA target	34988211	hsa-mir-648	esophagus adenocarcinoma	In this study, we sought to identify immune-related genes (IRGs) that are targeted by miR-3648 and develop an EA multigene signature.
lncRNA target	34988188	hsa-mir-126	Carcinoma, Hepatocellular	3p dramatically abolish the inhibitive influence of sh-TMPO-AS1 on HCC development.
target gene	34988161	hsa-mir-376b	Osteosarcoma	MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma.
other	34988135	hsa-mir-615	Hypertension	More importantly, three hub genes (NOTCH1, FOXO3, and STAT3) were recognized according to PPI network and three promising circRNA-miRNA-mRNA regulatory axes were found in hypertensive rat aorta, including rno_circRNA_0005818/miR-615/NOTCH1, rno_circRNA_0009197/ miR5p/FOXO3, and rno_circRNA_0005818/miR-10b-5p/STAT3, respectively.
other	34988135	hsa-mir-509	Hypertension	More importantly, three hub genes (NOTCH1, FOXO3, and STAT3) were recognized according to PPI network and three promising circRNA-miRNA-mRNA regulatory axes were found in hypertensive rat aorta, including rno_circRNA_0005818/miR-615/NOTCH1, rno_circRNA_0009197/ miR5p/FOXO3, and rno_circRNA_0005818/miR-10b-5p/STAT3, respectively.
other	34988028	hsa-mir-542	Carcinoma, Hepatocellular	the miRNA-542-3p-RFX6-DTX2-NOTCH1 regulatory pathway played significant roles in the tumor progression of liver hepatocellular carcinoma.
other	34988018	hsa-mir-664b	Urinary Bladder Neoplasms	Our results also identified the MSC-AS1/hsa-miR-664b-3p/TTK regulatory axis, which may also play an important role in the progression of BC, but further research is needed to verify this result.
circRNA target	34987549	hsa-mir-150	Osteoporosis	In conclusion, circRNA008876-miR5p-mRNA could be an important ceRNA network involved in senile osteoporosis, which provides potential biomarkers and therapeutic targets for senile osteoporosis.
circulation_biomarker_diagnosis_ns	34987392	hsa-mir-638	Hypertension, Pulmonary	Results: The relative expression level of miR-638 in the plasma was lower in the PAH patients than that in the controls (p < 0.001).
other	34987319	hsa-mir-6856	Sleep Apnea, Obstructive	5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS.
other	34987319	hsa-mir-595	Sleep Apnea, Obstructive	5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS.
other	34987319	hsa-mir-22	Sleep Apnea, Obstructive	5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS.
transcription factor target	34987126	hsa-mir-150	Colorectal Neoplasms	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-155	Colorectal Neoplasms	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-125b	Colorectal Neoplasms	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-150	Colitis	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-155	Inflammatory Bowel Diseases	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-150	Inflammatory Bowel Diseases	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-346	Colitis	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-125b	Inflammatory Bowel Diseases	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-506	Colitis	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-506	Inflammatory Bowel Diseases	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-506	Colorectal Neoplasms	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-346	Colorectal Neoplasms	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-155	Colitis	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-346	Inflammatory Bowel Diseases	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
transcription factor target	34987126	hsa-mir-125b	Colitis	Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease.
circRNA target	34987010	hsa-mir-1915	Stomach Neoplasms	CONCLUSIONS: Our study revealed that circ-ABCB10 promoted GC progression via targeting the miR3p/Rac1 axis, and circ-ABCB10 might be a potential target for GC diagnosis and treatment.
circulation_biomarker_diagnosis_up	34986898	hsa-mir-155	Toxoplasmosis	RESULTS: We observed that Toxoplasma infection upregulated miR5p expression in DC2.4 cell-secreted exosomes, and those exosomes could be ingested by murine macrophage RAW264.7 cells.
genetics_knock down_promote	34986861	hsa-mir-1197	Atherosclerosis	CONCLUSION: Our study revealed that knockdown of NCK1-AS1 attenuated the development of AS by regulating miR-1197/COX10 axis, suggesting that this lncRNA might be a potential therapeutic target for AS.
genetics_overexpression_suppress	34986816	hsa-mir-17	Acth-Independent Macronodular Adrenal Hyperplasia	Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH.
genetics_overexpression_suppress	34986816	hsa-mir-130b	Acth-Independent Macronodular Adrenal Hyperplasia	Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH.
genetics_overexpression_suppress	34986816	hsa-mir-20a	Acth-Independent Macronodular Adrenal Hyperplasia	Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH.
genetics_knock down_suppress	34986757	hsa-mir-142	Carcinoma, Hepatocellular	3p knockdown's influence on HCC in vivo.
lncRNA target	34986743	hsa-mir-1270	Stomach Neoplasms	Therefore, ASMTL-AS1/miR-1270 may be a potential prognostic biomarker and novel strategy for gastric cancer targeted therapy.
other	34986654	hsa-mir-338	Fibrosis	In this paper, we identify miR3p as a microRNA severely downregulated in the lungs of patients with pulmonary fibrosis and in experimental models of pulmonary fibrosis.
other	34986654	hsa-mir-338	Pulmonary Fibrosis	In this paper, we identify miR3p as a microRNA severely downregulated in the lungs of patients with pulmonary fibrosis and in experimental models of pulmonary fibrosis.
genetics_knock down_promote	34986537	hsa-mir-186	Liver Neoplasms	Knockdown of miR
transcription factor target	34986481	hsa-mir-27b	Testicular Diseases	CONCLUSION: miR-27b-3p could improve HG-induced spermatogenic cell damage via regulating Gfpt1/HBP signaling, providing a new treatment strategy for the treatment of DM-induced testicular damage.
transcription factor target	34986481	hsa-mir-27b	Diabetes Mellitus	CONCLUSION: miR-27b-3p could improve HG-induced spermatogenic cell damage via regulating Gfpt1/HBP signaling, providing a new treatment strategy for the treatment of DM-induced testicular damage.
genetics_overexpression_promote	34985712	hsa-mir-21	Carcinoma, Renal Cell	CONCLUSION: Expression of ACAT1 in KIRC is controlled at two levels, firstly by the hypermethylation of the ACAT1 promoter region and secondly by overexpression of miR
transcription factor target	34985594	hsa-mir-34a	Colorectal Neoplasms	Among them, AM22, with a base alteration from G to C at the 17(th) nucleotide of miR-34a, showed extensive antiproliferative activity against several colorectal tumor cell lines and achieved effective inhibition of core binding factor subunit beta (CBFB) expression.
other	34985397	hsa-mir-1	Diabetes Mellitus	5p mimics to treat the diabetic wound.
genetics_overexpression_promote	34985193	hsa-mir-619	Carcinoma, Non-Small-Cell Lung	5p overexpression inhibited NSCLC cell colony formation, migration, invasion, glycolysis and promoted cell apoptosis in vitro.
lncRNA target	34984723	hsa-mir-218	ankylosing spondylitis 1	OBJECTIVE: To investigate bone mineral density (BMD), bone metabolism-related factors, and microRNA-218 in Chinese ankylosing spondylitis (AS) patients and to identify their correlation with disease activities and the treatment with TNF-alpha inhibitors.
target gene	34984191	hsa-mir-200a	Urinary Bladder Neoplasms	miR-200a-3p facilitates bladder cancer cell proliferation by targeting the A20 gene.
other	34984022	hsa-mir-135a	Myocardial Fibrosis	CONCLUSION: We speculated that LINC00664/hsa-miR3p/JAK2 and GAS6-AS1/SNHG22/hsa-miR-135a-5p/CENPB/BCL9L interaction pairs may serve as potential biomarkers in MF after AMI.
other	34984022	hsa-mir-135a	Myocardial Infarction	CONCLUSION: We speculated that LINC00664/hsa-miR3p/JAK2 and GAS6-AS1/SNHG22/hsa-miR-135a-5p/CENPB/BCL9L interaction pairs may serve as potential biomarkers in MF after AMI.
other	34983931	hsa-mir-190b	Depression, Postpartum	In conclusion, cinnamaldehyde is a potential intervening agent for intergenerational inheritance of depression, probably by regulating GR/miR-190b/BDNF pathway.
lncRNA target	34983906	hsa-let-7d	Diabetic Cardiomyopathies	A total of 5 miRNAs were downregulated in the myocardial tissues of DCM rats and upregulated in H3 relaxin-treated DCM rats, and 1 miRNA (miRNA let-7d-3p) was increased in the myocardial tissue of DCM rats and decreased in H3 relaxin-treated DCM rats as revealed by miRNA microarray and validated by real-time polymerase chain reaction. The study revealed that H3 relaxin improved glucose uptake in DCM rats, potentially via the regulation of miRNA let-7d-3p.
circulation_biomarker_diagnosis_up	34983881	hsa-mir-186	Ischemic Stroke	5p is verified to be elevated in serum from ischaemic stroke patients.
other	34983831	hsa-mir-132	Parkinson Disease	3p and decreased expression of GLRX were found in PD patients and cells models.
lncRNA target	34983617	hsa-mir-550a	Breast Neoplasms	Further molecular mechanism research showed that circCCDC85A may act as a molecular sponge for miR-550a-5p, thus restoring miR-550a-5p-mediated targeting repression of tumor suppressor MOB1A in breast cancer cells.
genetics_knock down_suppress	34983615	hsa-mir-25	Multiple Myeloma	Using RNA and microRNA sequencing, we identified miR-551b and miR-25 as important miRs mediating Dex resistance in MM. Overexpression of miR-551b and miR-25 caused resistance to Dex, however, knockdown of miR-551b and miR-25 significantly enhanced Dex sensitivity in MM.
genetics_knock down_suppress	34983615	hsa-mir-551b	Multiple Myeloma	Using RNA and microRNA sequencing, we identified miR-551b and miR-25 as important miRs mediating Dex resistance in MM. Overexpression of miR-551b and miR-25 caused resistance to Dex, however, knockdown of miR-551b and miR-25 significantly enhanced Dex sensitivity in MM.
genetics_overexpression_promote	34983607	hsa-mir-32	Ovarian Neoplasms	MiR5p could be sponged by circ_0078607, and its overexpression could reverse the suppressive effect of circ_0078607 on OC progression.
genetics_overexpression_promote	34983591	hsa-mir-653	Arthritis, Rheumatoid	Functional assays showed that FGF2 overexpression neutralized the suppressive effects of miR
exosome	34983581	hsa-mir-155	Medulloblastoma	3p from M2 macrophages-derived exosomes (M2-Exo) in promoting medulloblastoma (MB) progression by mediating WD repeat domain 82 (WDR82).
genetics_overexpression_promote	34983563	hsa-mir-21	Myocardial Ischemia	In cardiomyocytes, ciRs-126 overexpression decreased miR-21 level and reduced the inhibitory effects of miR-21 overexpression on H/R-induced cell apoptosis.
lncRNA target	34983537	hsa-mir-497	Pancreatic Carcinoma	CONCLUSION: The upregulated circRTN4 promotes tumor growth and liver metastasis in PDAC through the novel circRTN4-miR
other	34983361	hsa-mir-29b	Carcinoma, Ovarian Epithelial	RESULTS: Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues. CONCLUSIONS: Taken together, our data revealed an oncogenic signalling pathway mediated by HCG18 in ovarian cell lines, which functions as a ceRNA of miR-29a/b and thus derepresses expression levels of TRAF4/5, facilitating NF-kappaB pathway-mediated promotion of EOC cell proliferation and migration.
other	34983361	hsa-mir-29a	Carcinoma, Ovarian Epithelial	RESULTS: Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues. CONCLUSIONS: Taken together, our data revealed an oncogenic signalling pathway mediated by HCG18 in ovarian cell lines, which functions as a ceRNA of miR-29a/b and thus derepresses expression levels of TRAF4/5, facilitating NF-kappaB pathway-mediated promotion of EOC cell proliferation and migration.
genetics_overexpression_suppress	34983308	hsa-mir-22	Carcinoma, Hepatocellular	Overexpression of miR
genetics_overexpression_promote	34983307	hsa-mir-373	Carcinoma, Hepatocellular	3p was downregulated, and its overexpression stepped up HCC cell apoptosis and suppressed migration and EMT.
lncRNA target	34983293	hsa-mir-1306	Carcinoma, Pancreatic Ductal	Our findings suggest that circUHRF1 regulated ARL4C expression to promote PDAC progression through sponging miR
genetics_knock down_promote	34982425	hsa-mir-195	Gallbladder Neoplasms	5p markedly attenuated the proliferation capacity of GBC cells as compared to the NC mimic group; in contrast, knockdown of microRNA
circRNA target	34982356	hsa-mir-1281	Glioma	MiR-1281 also inhibited glioma malignant progression by targeting ERBB4.
genetics_knock down_promote	34982022	hsa-mir-515	Carcinoma, Squamous Cell, Cutaneous	TPX2 overexpression largely overturned miR
circulation_biomarker_diagnosis_down	34981911	hsa-mir-423	Asthma	5p was downregulated in the serum of BA patients and was negatively correlated with PVT1.
lncRNA target	34981821	hsa-mir-96	Sepsis	In addition, GMDSAS1 expression increased, and upregulation of GMDSAS1 inhibited, the expression of miR965p in the in vitro sepsis model. In summary, the findings of the present study demonstrated that lncRNA GMDSAS1 could promote the development of sepsis by targeting miR965p/CASP2, indicating that the GMDSAS1/miR965p/CASP2 axis may be a new therapeutic target and potential research direction for sepsis therapy.
genetics_knock down_promote	34981816	hsa-mir-20b	Ceroid lipofuscinosis, neuronal 5	Taken together, the results of the present study suggest that NEAT1 knockdown promotes phenotypic transformation of AMs from M1 to M2 and alleviates lung injury and apoptosis of VILI by regulating miR20b expression.
genetics_knock down_promote	34981816	hsa-mir-20b	Lung Injury	Taken together, the results of the present study suggest that NEAT1 knockdown promotes phenotypic transformation of AMs from M1 to M2 and alleviates lung injury and apoptosis of VILI by regulating miR20b expression.
other	34981813	hsa-mir-29c	Leukemia, Lymphocytic, Chronic, B-Cell	Moreover, the expression levels of miR15a and miRNA29c were demonstrated to be significantly higher in the group of patients with CLL who had a tumor protein p53 deletion, identified by FISH, compared with patients without this lesion (P=0.047, P=0.03 respectively).
genetics_overexpression_promote	34981812	hsa-mir-1291	Colonic Neoplasms	Furthermore, miR1291 induced CDK inhibitors p21(WAF1/CIP1) and p27(KIP1) in three CRC cell lines, and the overexpression of DCLK1 in HCT116 cells led to a decrease of p21(WAF1/CIP1) and p27(KIP1).
other	34981661	hsa-mir-185	Pulmonary Arterial Hypertension	5p, are significantly associated with IPAH.
other	34981661	hsa-mir-103a	Pulmonary Arterial Hypertension	5p, are significantly associated with IPAH.
other	34981461	hsa-mir-30	Pneumonia, Mycoplasma	Our study identifies circ_0017068 as an important regulator of the proliferation and apoptosis of HTR-8/SVneo trophoblast cells at least in part by miR5p-dependent regulation of XIAP, highlighting circ_0017068 as a potential therapeutic agent for PE treatment.
genetics_GWAS	34981334	hsa-mir-146a	Brucellosis	Current research studied the impact of the miR-146a polymorphism on miR-146a, TRAF-6, and IRAK-1 genes expression in patients with brucellosis illness.
lncRNA target	34981333	hsa-mir-34a	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
lncRNA target	34981333	hsa-mir-9	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
lncRNA target	34981333	hsa-mir-155	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
lncRNA target	34981333	hsa-mir-138	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
lncRNA target	34981333	hsa-mir-101	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
lncRNA target	34981333	hsa-mir-200c	Salivary Gland Neoplasms	METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples.
genetics_overexpression_suppress	34981113	hsa-mir-335	Endothelial Dysfunction	5p inhibitor attenuated the down-regulation of SIRT7 expression induced by oxidative stress in HUVECs, and SIRT7 overexpression exerts a rescue effect against miR
other	34981016	hsa-mir-144	Multiple Sclerosis	MIR-144 can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.
other	34980214	hsa-mir-24	Ovarian Neoplasms	3p/LY6K signaling to facilitate progression of ovarian cancer.
genetics_knock down_suppress	34980204	hsa-mir-23a	Carcinoma, Hepatocellular	CRISPR-Cas9 knockout of miR-23a-3p improved sorafenib response in HCC cells as well as orthotopic HCC tumours.
other	34980201	hsa-mir-195	Carcinoma, Hepatocellular	CONCLUSIONS: Our finding indicated that there existed a TINCR/miR3p/ST6GAL1/NF-kappaB signaling regulatory axis that regulated tumor progression and oxaliplatin resistance, which might be exploited for anticancer therapy in HCC.
lncRNA target	34980191	hsa-mir-100	Nasopharyngeal Carcinoma	In addition, we confirmed that ZFAS1 can regulate the autophagy level of NPC cells through the PI3K/AKT pathway through miR
genetics_knock down_promote	34980181	hsa-mir-125a	Multiple Myeloma	Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group.
genetics_knock down_promote	34980181	hsa-mir-125b	Multiple Myeloma	Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group.
other	34980144	hsa-mir-23b	Liver Neoplasms	CONCLUSION: T cell-related RNAs EOMES, CST7, CD5L, has-miR-23b-3p, and has-miR-23a-3p may be associated with the prognosis of liver cancer.
other	34980144	hsa-mir-23a	Liver Neoplasms	CONCLUSION: T cell-related RNAs EOMES, CST7, CD5L, has-miR-23b-3p, and has-miR-23a-3p may be associated with the prognosis of liver cancer.
lncRNA target	34980138	hsa-mir-181b	Craniopharyngioma	miR-181b, the expression of which was increased in Bmp2-induced ACP cells, directly targeted and decreased CBX4 expression and inhibited the nuclear localization of HDAC3. CONCLUSIONS: Our results demonstrate that Bmp2 increases miR-181b levels to directly target and inhibit CBX4 expression, leading to a reduction in the CBX4-dependent regulation of HDAC3 nuclear translocation, which results in Runx2 activation/osteoblastic differentiation and calcium deposition in ACP.
other	34979848	hsa-mir-19a	Triple Negative Breast Neoplasms	miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645.
other	34979848	hsa-mir-520f	Triple Negative Breast Neoplasms	miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645.
other	34979848	hsa-mir-520b	Triple Negative Breast Neoplasms	miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645.
other	34979848	hsa-mir-335	Triple Negative Breast Neoplasms	miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645.
other	34979511	hsa-mir-622	Osteoarthritis	CONCLUSION: CircCCDC66 promoted OA chondrocyte apoptosis by regulating the miR-3622b-5p/SIRT3 axis.
genetics_overexpression_suppress	34979422	hsa-mir-582	Urinary Bladder Neoplasms	Overexpression of FOXG1 rescued the regulating function in BCa cells induced by miR-582.
lncRNA target	34979378	hsa-mir-21	Lung Neoplasms	5p inhibitor can more effectively suppress the development of lung cancer.
other	34979377	hsa-mir-92a	Osteoarthritis	Collectively, MF regulated the biological functions of OA synoviocytes by upregulating miR-92a-3p expression.
genetics_overexpression_suppress	34979376	hsa-mir-369	Carcinoma, Hepatocellular	Concurrently, HOXA13 overexpression could counteract the effects of miR
other	34979347	hsa-mir-223	Cognition Disorders	CONCLUSION: Propofol reduced inflammation by up-regulating miR3p, thereby reducing POCD in aged rats.
other	34979168	hsa-mir-20b	Inflammation	In summary, this study suggested that LncRNA2264 acted as a miR-20b-5p molecular sponge to regulate the expression of IL17RD involved in H(2)S exposure-induced thymic inflammation, which has positive implications for guiding the prevention and control of H(2)S gas poisoning in livestock housing and ensuring animal welfare.
circulation_biomarker_prognosis_ns	34979060	hsa-mir-601	Lung Neoplasms	The aim of this study is to examine miRNA-601 and PD-L1 gene expression in patients with non-small-cell lung cancer (NSCLC) and its relation with Mycoplasma infection. CONCLUSION: Serum miRNA-601 may act as a potential noninvasive biomarker for lung cancer and Mycoplasma infection prognosis.
circulation_biomarker_prognosis_ns	34979060	hsa-mir-601	Mycoplasma Infections	The aim of this study is to examine miRNA-601 and PD-L1 gene expression in patients with non-small-cell lung cancer (NSCLC) and its relation with Mycoplasma infection. CONCLUSION: Serum miRNA-601 may act as a potential noninvasive biomarker for lung cancer and Mycoplasma infection prognosis.
genetics_overexpression_suppress	34978893	hsa-mir-769	Carcinoma, Non-Small-Cell Lung	Furthermore, more research revealed that HDGF overexpression reduced the inhibitory effect of miR
transcription factor target	34978772	hsa-mir-181a	Allergic Inflammation	CONCLUSION: The results suggest that miR-181a-5p restricted allergic inflammation through inhibition of IL-33/p38 MAPK pathway, indicating miR-181a-5p may play an anti-inflammatory role in AR.
genetics_knock down_suppress	34978519	hsa-mir-582	Triple Negative Breast Neoplasms	5p enhanced TNBC cell migration and invasion, whereas knockdown of miR
lncRNA target	34978518	hsa-mir-6720	Diabetic Retinopathy	5p and regulate the expression of CYB5R2, thereby inhibiting DR neovascularization.
genetics_overexpression_promote	34978464	hsa-mir-655	Carcinoma, Hepatocellular	SMAD5, which was overexpressed in HCC cell lines, was directly targeted by miR
circRNA target	34978116	hsa-mir-23a	Reperfusion Injury, Cerebral Ischemia	In conclusion, circCDC14A promoted CI/R injury by regulating the miR-23a-3p/CXCL12 axis, which suggested that circCDC14A may become a potential therapeutic target for CI/R injury.
other	34978042	hsa-mir-127	Pneumonia, Mycoplasma	Our research indicated that circPAPPA positively regulated the biological function of trophoblast cells to mediate the progression of PE by miR5p/HOXA7 axis, which suggested that circPAPPA might be a potential biomarker for PE.
exosome	34978010	hsa-mir-744	Glioma	AIM: Our current study is conducted with intention to explore the regulatory mechanism of mesenchymal stem cell (MSC)-derived extracellular vesicle (EV)-miR
lncRNA target	34977878	hsa-mir-335	Adenocarcinoma of Lung	Here, we revealed that hsa-miR-335, a previously reported tumor suppressor, exhibited an oncogenic role in LAC. This finding not only highlights the suppressive effect of CPNE1 on cell motility, but also provides new insight into miR-335 in promoting LAC metastasis.
circulation_biomarker_diagnosis_up	34977596	hsa-mir-455	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
circulation_biomarker_diagnosis_up	34977596	hsa-mir-23b	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
circulation_biomarker_diagnosis_up	34977596	hsa-mir-499	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
circulation_biomarker_diagnosis_up	34977596	hsa-mir-140	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
circulation_biomarker_diagnosis_up	34977596	hsa-mir-5099	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
circulation_biomarker_diagnosis_up	34977596	hsa-mir-6238	Osteoarthritis, Post-Traumatic	The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR
target gene	34977284	hsa-mir-218	Osteosarcoma	MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells.
circulation_biomarker_diagnosis_ns	34977204	hsa-mir-146a	Rhiny	Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos.
circulation_biomarker_diagnosis_ns	34977204	hsa-let-7g	Intervertebral disc disease	let-7g, miR-30e, and miR-143 all showed significant increased expression (P 0.05) during IOD (between 1 and 2 years prior to death) and late IOD (within 1 year of death) compared to healthy and unhealthy individuals. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
circulation_biomarker_diagnosis_ns	34977204	hsa-mir-16b	Rhiny	Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos.
circulation_biomarker_diagnosis_ns	34977204	hsa-mir-143	Rhiny	Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
circulation_biomarker_diagnosis_ns	34977204	hsa-let-7g	Body Integrity Identity Disorder	Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
circulation_biomarker_diagnosis_ns	34977204	hsa-let-7g	Rhiny	Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
circulation_biomarker_diagnosis_ns	34977204	hsa-mir-143	Intervertebral disc disease	let-7g, miR-30e, and miR-143 all showed significant increased expression (P 0.05) during IOD (between 1 and 2 years prior to death) and late IOD (within 1 year of death) compared to healthy and unhealthy individuals. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
other	34977204	hsa-mir-16b	Intervertebral disc disease	miR-16b expression increased (P 0.05) in late IOD, but was not different among IOD, healthy, and unhealthy states (P &gt; 0.05).
other	34977204	hsa-mir-146a	Intervertebral disc disease	Expression of miR-146a increased in IOD and late IOD as compared to unhealthy samples (P 0.05) but was not different from the healthy state (P &gt; 0.05).
circulation_biomarker_diagnosis_ns	34977204	hsa-mir-143	Body Integrity Identity Disorder	Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated.
other	34977182	hsa-mir-153	Endomyocardial Fibrosis	Recovery experiments with miR3p antagomir resulted in the reversal of FA-induced cardiomyocyte apoptosis and fetal cardiac fibrosis.
transcription factor target	34977182	hsa-mir-153	Coronary Disease	The study findings suggest that miR3p may provide a potential target for the clinical diagnosis and treatment of CHD.
genetics_GWAS	34977033	hsa-mir-1269b	Diabetic Nephropathies	MiR-1269b-FBLN1 epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN.
transcription factor target	34977023	hsa-mir-375	Diabetic Retinopathy	3p is a potential target for the diagnosis or treatment of DR.
target gene	34977016	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	Cancer-Associated Fibroblasts Promote Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-101-3p Mediated VEGFA Secretion and AKT/eNOS Pathway.
lncRNA target	34977002	hsa-mir-1179	ankylosing spondylitis 1	Through dual-luciferase assays and RNA pull-down assays, we demonstrated that hsa_circ_0000652 acted as a competing endogenous RNA (ceRNA) by binding with hsa-miR-1179 and regulated OX40L, which is characterized as a co-stimulatory molecule and found to be upregulated in AS patients. Our findings suggest that hsa_circ_0000652 was upregulated in AS patients and may serve as a pro-inflammatory factor in macrophages and a positive regulator of OX40/OX40L by sponging hsa-miR-1179.
target gene	34976998	hsa-mir-103a	Breast Neoplasms	Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α-Positive Feedback Loop.
target gene	34976797	hsa-mir-20a	Carcinoma, Hepatocellular	MicroRNA-20a Suppresses Tumor Proliferation and Metastasis in Hepatocellular Carcinoma by Directly Targeting EZH1.
genetics_overexpression_promote	34976438	hsa-mir-574	Insulin Resistance	The overexpression of miR
other	34976438	hsa-mir-574	Diabetes Mellitus, Type 2	Additionally, miR5p expression was significantly higher in the subcutaneous adipose tissue of obese patients without type 2 diabetes than in those with type 2 diabetes.
transcription factor target	34976438	hsa-mir-574	Obesity	5p may be a potential therapeutic target for combating obesity-related IR.
circulation_biomarker_diagnosis_ns	34976409	hsa-mir-29b	Coronary Artery Disease	CONCLUSIONS: These data suggest that circulating miRNA-29b and sclerostin levels are correlated with CAC and incidence of CVEs in MHD patients.
circulation_biomarker_diagnosis_ns	34976409	hsa-mir-29b	Coronary Artery Calcification	CONCLUSIONS: These data suggest that circulating miRNA-29b and sclerostin levels are correlated with CAC and incidence of CVEs in MHD patients.
lncRNA target	34976325	hsa-mir-24	Pancreatic Carcinoma	CONCLUSION: LINC01320 is highly expressed in PC, and it can suppress the growth and migration of PC cells through targeted regulation of miR3p, which is expected to become a latent target for clinical treatment.
lncRNA target	34976303	hsa-mir-155	Encephalomyelitis, Autoimmune, Experimental	In summary, our study suggests that APS regulates the polarization of microglia from M1 to M2 phenotype by inhibiting the miR-155, reduces the secretion of inflammatory factors, and inhibits the activation of neurotoxic astrocytes, thus effectively treating EAE.
target gene	34976194	hsa-mir-424	Prostatic Neoplasms	Long non-coding RNA MAGI2-AS3 inactivates STAT3 pathway to inhibit prostate cancer cell proliferation via acting as a microRNA-424-5p sponge.
other	34976193	hsa-mir-5703	Liver Neoplasms	The expression of miRNA-5703 was higher in liver cancer tissues from Barcelona Clinic Liver Cancer (BCLC) stage A1 patients than those from BCLC stage A2-D patients, whereas SRC showed the opposite expression pattern.
other	34976187	hsa-mir-495	Colorectal Neoplasms	HGF/c-MET regulatory network involved in cetuximab resistance in CRC.
target gene	34976171	hsa-mir-449a	Carcinoma, Hepatocellular	Ago-RIP Sequencing Identifies New MicroRNA-449a-5p Target Genes Increasing Sorafenib Efficacy in Hepatocellular Carcinoma.
target gene	34976169	hsa-mir-519	Pancreatic Neoplasms	Hsa_circ_0074298 promotes pancreatic cancer progression and resistance to gemcitabine by sponging miR-519 to target SMOC.
other	34976151	hsa-mir-215	Breast Neoplasms	Long non-coding RNA GAS6-AS1 enhances breast cancer cell aggressiveness by functioning as a competing endogenous RNA of microRNA-215-5p to enhance SOX9 expression.
target gene	34976140	hsa-mir-130b	Prostatic Neoplasms	miR-130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways.
target gene	34976139	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	MicroRNA-141-3p inhibits the progression of oral squamous cell carcinoma via targeting PBX1 through the JAK2/STAT3 pathway.
other	34976024	hsa-mir-27b	Graves Ophthalmopathy	Conclusion: An innovative lncRNA/circRNA-miRNA-mRNA ceRNA network between GO patients and control patients was constructed, and two important ceRNA pathways were identified, the LINC01820:13-hsa-miR-27b-3p-FPR2 ceRNA pathway and the ENST00000499452-hsa-miR-27a-3p-CXCL1 pathway, which probably affect the autoimmune response and inflammation in GO patients.
other	34976024	hsa-mir-27a	Graves Ophthalmopathy	Conclusion: An innovative lncRNA/circRNA-miRNA-mRNA ceRNA network between GO patients and control patients was constructed, and two important ceRNA pathways were identified, the LINC01820:13-hsa-miR-27b-3p-FPR2 ceRNA pathway and the ENST00000499452-hsa-miR-27a-3p-CXCL1 pathway, which probably affect the autoimmune response and inflammation in GO patients.
target gene	34976014	hsa-mir-326	Uterine Cervical Neoplasms	Downregulation of hsa_circRNA_0001400 Helps to Promote Cell Apoptosis Through Disruption of the circRNA_0001400-miR-326 Sponge in Cervical Cancer Cells.
other	34976005	hsa-mir-200a	Heart Arrest	Finally, we predicted that Lcorl-miR-200a-3p-Ttr, BRD4-Ccl2 and Ep300-miR-200b-3p-Tmem72 may participate in the pathogenesis of DHCA cerebral injury.
other	34976005	hsa-mir-200b	Heart Arrest	Finally, we predicted that Lcorl-miR-200a-3p-Ttr, BRD4-Ccl2 and Ep300-miR-200b-3p-Tmem72 may participate in the pathogenesis of DHCA cerebral injury.
circulation_biomarker_diagnosis_ns	34975837	hsa-mir-146a	Arthritis, Rheumatoid	RESULTS: Serum samples from RA patients treated with TCZ exhibited reduced circulating levels of EMMPRIN/CD147, enhanced expression of circulating miR-146a-5p and miR5p, and reduced the angiogenic potential as was manifested by the lower number of tube-like structures that were formed by EaHy926 endothelial cell line.
transcription factor target	34974862	hsa-mir-214	Intestinal Neoplasms	Our study aimed at studying mechanism of miR-214 packaged with lipidosome nanoparticles on prompting apoptosis of intestinal cancer through regulating p53 pathway. The effect of miR-214 packaged with lipidosome nanoparticles on proliferation and apoptosis of intestinal cancer cells and p53 pathway in intestinal cancer cells was observed.
lncRNA target	34974815	hsa-mir-497	Breast Neoplasms	We further identified miR5p as a negative regulator of PAPPA, which suppressed cell proliferation, migration, invasion, and EMT in breast cancer cells.
genetics_knock down_promote	34974809	hsa-mir-518a	Squamous Cell Carcinoma of Head and Neck	In addition, miR-518a could inhibit spermatogenesis-associated serine-rich 2-like (SPATS2L) expression by direct interaction, and upregulation of SPATS2L abrogated the inhibitory effect of HOXA11-AS silencing or miR-518a overexpression on CDDP resistance of CDDP-resistant LSCC cells.
genetics_knock down_promote	34974806	hsa-mir-196b	Keloid	Knockdown of H19, overexpression of miR-196b-5p, or knockdown of SMAD5 inhibited the viability and proliferation of keloid fibroblasts and promoted apoptosis.
genetics_knock down_promote	34974791	hsa-mir-136	Colorectal Neoplasms	5p knockdown attenuated the influence of circPTK2 silence on CRC progression and chemoresistance.
genetics_knock down_suppress	34974242	hsa-mir-541	Cholangiocarcinoma	CONCLUSION: CircRTN4IP1 knockdown inhibited ICC cell malignancy by miR
genetics_knock down_promote	34974169	hsa-mir-136	Carcinoma, Hepatocellular	5p overexpression-induced influences in HCC cells.
genetics_knock down_promote	34974134	hsa-mir-185	Glioma	5p inhibition reversed the anticancer effects of circPOSTN knockdown on glioma tumorigenesis, and miR
lncRNA target	34974133	hsa-mir-511	Spinal Cord Injuries	3p may be a potential therapeutic target for SCI.
genetics_knock down_suppress	34974108	hsa-mir-766	Chorea	MiR5p knockdown decreased cell viability, proliferation and migration of SCs, and also reversed the effects of lnc-RMRP silencing.
transcription factor target	34973648	hsa-mir-7	Metabolic Diseases	These results reveal a novel miRNA-mediated mechanism of heat treatment on the regulation of lactate metabolism production, and suggest that targeting miR5p is a probably therapeutic method to insulin dysfunction-induced metabolic diseases.
other	34973370	hsa-mir-122	Femur Head Necrosis	5p/GREM2 axis is worthy of further investigation.
exosome	34973299	hsa-mir-221	Diabetes Mellitus	3p in diabetic wound healing and may be a novel therapeutic target for diabetic foot ulcer.
lncRNA target	34973275	hsa-mir-142	Uterine Cervical Neoplasms	3p acts as a tumor-suppressive miRNA by targeting HMGA1, A2, B1, and B3 and may serve as a potential therapeutic agent in human cervical cancer.
genetics_knock down_promote	34972532	hsa-mir-671	Stomach Neoplasms	CONCLUSIONS: Circ_0000620 knockdown inhibited the malignant development of GC partly through modulating the miR
other	34972164	hsa-mir-141	Prostatic Neoplasms	A lot of micro-RNAs have been known in relation to prostate cancer (PCa), and we evaluate miR-21, miR-141, and miR-221 in EVs and compare them with prostate-specific antigen (PSA). The levels of miR-21 and miR-141 in EVs did not show significant changes in patients with PCa compared to the control group in this study.
other	34972164	hsa-mir-21	Prostatic Neoplasms	A lot of micro-RNAs have been known in relation to prostate cancer (PCa), and we evaluate miR-21, miR-141, and miR-221 in EVs and compare them with prostate-specific antigen (PSA). The levels of miR-21 and miR-141 in EVs did not show significant changes in patients with PCa compared to the control group in this study.
circulation_biomarker_diagnosis_ns	34972164	hsa-mir-221	Prostatic Neoplasms	Area under curve (AUC) between BPH and PCa for miR-221 was 0.98 (p < 0.0001), which was better than AUC for prostate-specific antigen (PSA) level in serum for the same patients.
circulation_biomarker_diagnosis_ns	34971908	hsa-mir-203a	Schizophrenia	In whole blood and blood-derived exosomes of 11 first episode antipsychotic naive schizophrenia patients, DJ-1 protein and mRNA demonstrated decreased DJ-1 mRNA and protein and increased miR203a-3p levels compared to healthy controls.
lncRNA target	34971743	hsa-mir-17	Hematologic Diseases	In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity.
circulation_biomarker_diagnosis_up	34971719	hsa-mir-19b-1	Spinal Cord Injuries	5p in SCI was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and GFAP expression.
circulation_biomarker_diagnosis_up	34971719	hsa-mir-19b	Spinal Cord Injuries	5p in SCI was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and GFAP expression.
genetics_knock down_promote	34970865	hsa-mir-340	Myocardial Reperfusion Injury	CONCLUSIONS: Knockdown of XIST up-regulates miR
transcription factor target	34970742	hsa-mir-148a	Prostatic Neoplasms, Castration-Resistant	METHODS: Prostate cancer-specific miR-148a, -365, -375, and -429 were analyzed in 129 urine samples collected from 100 CRPC patients before and during AA therapy via quantitative reverse transcription PCR.
lncRNA target	34970545	hsa-mir-195	Carcinoma, Hepatocellular	Conclusion: LINC01572 acts as ceRNA of miR5p to restrict its inhibition of PFKFB4, thereby enhancing glycolysis and activates PI3K/AKT signaling to trigger HCC malignancy.
genetics_GWAS	34970542	hsa-mir-155	Asthma	We discovered 11 crucial ceRNA regulations concerning asthma disease feature pathway and propose a potential mechanism of ceRNA regulatory SNP --> gene --> pathway --> disease feature effecting asthma pathogenesis, especially for MALAT1 (rs765499057/rs764699354/rs189435941) --> hsa-miR-155 --> IL13 (rs201185816/rs1000978586/rs202101165) --> Interleukin-4 and Interleukin-13 signaling --> inflammation/airway remodeling and MALAT1 (rs765499057/rs764699354/rs189435941) --> hsa-miR-155 --> IL17RB (rs948046241) --> Interleukin-17 signaling (airway remodeling)/Cytokine-cytokine receptor interaction (inflammation).
genetics_overexpression_promote	34970357	hsa-mir-126	Acidosis, Respiratory	Enhanced expression of HMGB1 and downstream inflammation markers was blocked by the premiR-126 overexpression and optimized by antagomiR.
other	34970356	hsa-mir-138	Iris Diseases	OBJECTIVE: To investigate the effects of HOX transcript antisense RNA (HOTAIR) and miR-138 on inflammatory response and oxidative stress (OS) induced by IRI in rat cardiomyocytes.
lncRNA target	34970356	hsa-mir-138	Opitz GBBB Syndrome, X-Linked	OBJECTIVE: To investigate the effects of HOX transcript antisense RNA (HOTAIR) and miR-138 on inflammatory response and oxidative stress (OS) induced by IRI in rat cardiomyocytes. CONCLUSIONS: Silent HOTAIR can promote the expression of miR-138 and inhibit H/R-induced inflammatory response and OS by regulating the NF-kappaB pathway, thus protecting cardiomyocytes.
other	34970354	hsa-mir-603	Inflammatory Bowel Diseases	Taken together, the results of the present study suggest that NEAT1 contributes to the development of UC by regulating the miR-603/FGF9 pathway.
other	34970350	hsa-mir-27b	Osteoporosis	However, the mechanism underlying miR-27b in osteoporosis remains to be elucidated.
other	34969953	hsa-mir-24	Schizophrenia	3p/NOS3.
other	34969953	hsa-mir-335	Schizophrenia	3p/NOS3.
other	34969953	hsa-mir-34a	Schizophrenia	3p/NOS3.
other	34969953	hsa-mir-7	Schizophrenia	3p/NOS3.
genetics_overexpression_promote	34969362	hsa-mir-185	Late Onset Disorders	FGR foetuses overexpress miR
genetics_overexpression_promote	34969362	hsa-mir-185	Growth Disorders	FGR foetuses overexpress miR
lncRNA target	34969361	hsa-mir-10a	Stomach Neoplasms	In summary, miR-10a-5p from GC cells-derived exo enhances viability and migration of HUVECs by suppressing ZMYND11.
genetics_knock down_promote	34969360	hsa-mir-495	Colorectal Neoplasms	Thus, the current data highlight that NORAD knockdown may antagonize hypoxia-triggered CRC malignancy by suppressing VM formation and chemoresistance by sponging miR
genetics_knock down_promote	34969359	hsa-mir-132	Retinoblastoma	3p knockdown on RB cells.
other	34969357	hsa-mir-647	Carcinoma, Hepatocellular	However, the regulatory mechanisms mediated by miR-647 involved in HCC remain unclear. Hence, to clarify the regulatory mechanisms mediated by miR-647 in HCC, we studied the independent effects of miR-647 and explored protein tyrosine phosphatase receptor type F (PTPRF) in the constructed HCC cell line (HCV-huh7.5).
circulation_biomarker_diagnosis_ns	34969354	hsa-mir-134	Diabetes, Gestational	5p was increased in the serum of GDM patients and could serve as a critical diagnostic marker for GDM.
circulation_biomarker_diagnosis_ns	34969353	hsa-mir-132	Epilepsy	Plasma miR-146a and miR-132 expressions increased in epileptic patients, and miR-132 expression reflected the severity of epilepsy and predicted the risks of complications.
circulation_biomarker_diagnosis_ns	34969353	hsa-mir-146a	Epilepsy	Plasma miR-146a and miR-132 expressions increased in epileptic patients, and miR-132 expression reflected the severity of epilepsy and predicted the risks of complications.
genetics_GWAS	34969167	hsa-mir-149	Mucocutaneous Lymph Node Syndrome	CONCLUSIONS: Our results demonstrated that the miR-149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients.
genetics_GWAS	34969167	hsa-mir-196a-2	Mucocutaneous Lymph Node Syndrome	The present study further focused on the relationship between three miRNA polymorphisms (miR-149 rs2292832 T>C, miR-196a2 rs11614913 C>T and miR-499a rs3746444 A>G) and the risk of coronary artery aneurysm (CAA) in southern Chinese KD patients.
genetics_GWAS	34969167	hsa-mir-499a	Mucocutaneous Lymph Node Syndrome	CONCLUSIONS: Our results demonstrated that the miR-149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients.
other	34968919	hsa-mir-30	Osteosarcoma	3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer.
other	34968919	hsa-mir-30	Carcinoma, Hepatocellular	Dual roles of miR5p have been also indicated in the thyroid, liver and cervical cancers.
other	34968919	hsa-mir-30	Urinary Bladder Neoplasms	Moreover, miR3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer.
other	34968919	hsa-mir-30	Pancreatic Carcinoma	3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer.
other	34968919	hsa-mir-30	hereditary diffuse gastric cancer	In many cancer types (such as lung, prostate, gastric, breast, bladder, ovarian, colorectal, and pancreatic cancer, and osteosarcoma), miR5p acts as an anti-tumor agent.
other	34968919	hsa-mir-30	Lung Neoplasms	Moreover, miR3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer.
other	34968919	hsa-mir-30	Uterine Cervical Neoplasms	3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer.
other	34968919	hsa-mir-30	Breast Neoplasms	Demonstrated in breast and liver cancers, miR3p also has dual roles.
other	34968855	hsa-mir-10b	Breast Neoplasms	Herein, a cotton thread-based multi-channel photothermal biosensor was proposed for simultaneous detection of three breast cancer-related miRNAs including miRNA-10b, miRNA-27a and miRNA-let-7a.
other	34968855	hsa-mir-27a	Breast Neoplasms	Herein, a cotton thread-based multi-channel photothermal biosensor was proposed for simultaneous detection of three breast cancer-related miRNAs including miRNA-10b, miRNA-27a and miRNA-let-7a.
genetics_knock down_promote	34968780	hsa-mir-524	Chondrosarcoma	Mechanistically, although knockdown of YAP upregulated both the nuclear and cytoplasmic TXNIP expression, we did not observe any obvious interaction between YAP and TXNIP; instead, miRNA
other	34968461	hsa-mir-133a	Myocardial Reperfusion Injury	The expression of MALAT1, miR-133a-3p in MIRI were evaluated using real-time quantitative polymerase chain reaction (qRT-PCR)immunohistochemistry (IHC) and western blot (WB). In summary, these results suggest that MALAT1 and miR-133a-3p play important roles in MIRI.
other	34968168	hsa-mir-1-1	Intrauterine Adhesion	Crucial lncRNAs such as ADIRF-AS1, LINC00632, DIO3OS, MBNL1-AS1, MIR1-1HG-AS1, AC100803.2 was involved in the development of IUA.
genetics_overexpression_promote	34968167	hsa-mir-128	Stomach Neoplasms	In addition, GC cells were cocultured with T lymphocytes, and the subsequent flow cytometric analysis showed that overexpression of miR
genetics_overexpression_promote	34968160	hsa-mir-20b	Carcinoma, Non-Small-Cell Lung	Overall, miR-20b-5p overexpression combined with Pembrolizumab potentiated cancer cells' sensitivity to RT by repressing PD-L1/PD1.Abbreviations Akt: serine/threonine kinase 1; cDNA: complementary DNA; CO(2): carbon dioxide; EDTA: Ethylene Diamine Tetraacetic Acid; ENCORI: The Encyclopedia of RNA Interactomes; GAPDH: glyceraldehyde
genetics_overexpression_promote	34968160	hsa-mir-20b	Small Cell Lung Carcinoma	Overall, miR-20b-5p overexpression combined with Pembrolizumab potentiated cancer cells' sensitivity to RT by repressing PD-L1/PD1.Abbreviations Akt: serine/threonine kinase 1; cDNA: complementary DNA; CO(2): carbon dioxide; EDTA: Ethylene Diamine Tetraacetic Acid; ENCORI: The Encyclopedia of RNA Interactomes; GAPDH: glyceraldehyde
lncRNA target	34967761	hsa-mir-141	Endometriosis	5p are possible biomarkers and therapeutic targets for endometriosis.
lncRNA target	34967707	hsa-let-7c	Lung Neoplasms	DISCUSSION AND CONCLUSION: CuB regulated cell proliferation and apoptosis by inhibiting the XIST/miR-let-7c/IL-6/STAT3 axis in lung cancer.
lncRNA target	34967706	hsa-mir-221	Parkinson Disease	LncRNA MIAT promoted MPP(+)-induced neuronal injury in PD via regulating TGF-beta1/Nrf2 axis through binding with miR3p.
lncRNA target	34967706	hsa-mir-221	Epilepsy	LncRNA MIAT promoted MPP(+)-induced neuronal injury in PD via regulating TGF-beta1/Nrf2 axis through binding with miR3p.
lncRNA target	34967697	hsa-mir-1277	Neuroblastoma	These data suggest that SNHG10 regulates IRS2 through interacting with miR
lncRNA target	34967592	hsa-mir-21	Nasopharyngeal Carcinoma	The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets.
other	34967587	hsa-mir-145	Colorectal Neoplasms	5p and NRAS can be utilized as diagnostic biomarkers in colorectal cancer death.
circRNA target	34967281	hsa-mir-486	Squamous Cell Carcinoma of Head and Neck	Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of miR
circRNA target	34967281	hsa-mir-637	Squamous Cell Carcinoma of Head and Neck	Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of miR
lncRNA target	34967274	hsa-mir-582	Colorectal Neoplasms	Collectively, our data suggest that lncRNA DCST1-AS1 regulates the aggressiveness of CRC cells through hsa-miR
lncRNA target	34967266	hsa-mir-19a	Polycystic Ovary Syndrome	MicorRNA-19a (miR-19a) is a well-characterized miRNA in cancer biology and its function is mainly mediated by targeting tumor necrosis factor alpha (TNF-alpha), which plays critical roles in PCOS. Therefore, PLAC2 may regulate miR-19a/TNF-alpha to participate in PCOS.
transcription factor target	34967265	hsa-mir-21	Breast Neoplasms	5p inhibitor with reversine produced a synergistic effect by regulating SPRY2, thereby limiting HBC progression.
lncRNA target	34967264	hsa-mir-186	Osteochondritis Dissecans	Moreover, miR5p inhibition or YY1 upregulation abolished the effects of SOX2-OT blocking on the inflammatory responses, proliferation, and apoptosis of OGD/R-challenged H2C9 cells.
lncRNA target	34967264	hsa-mir-186	Myocardial Reperfusion Injury	In conclusion, our results, for the first time, demonstrated that SOX2-OT inhibition attenuated MI/R injury in vitro via regulating the miR5p/YY1 axis, offering potential therapeutic targets for MI/R injury treatment.
other	34966905	hsa-mir-122	Liver Injury	In addition, microRNA-122 is sensitive for early detection of liver injury in acetaminophen overdose patients.
genetics_overexpression_suppress	34966644	hsa-mir-7	Cholangiocarcinoma	Overexpression of MyD88 counteracted the effects of miR
circulation_biomarker_prognosis_up	34966454	hsa-mir-103a	Breast Neoplasms	The circulating serum miR-103a-3p level could be used to discriminate between patients with BC and the healthy controls prior to surgery using an area under curve [(AUC), 0.697; 95% confidence intervals (CI), 0.615-0.778], and distinguish patients with BC and metastasis from those without metastasis (AUC, 0.936; 95% CI, 0.892-0.980).
genetics_overexpression_promote	34966442	hsa-mir-429	Osteochondritis Dissecans	The results showed that miR-429 was significantly upregulated in the serums of the patients, and overexpressed miR-429 could extremely inhibit the viability, migration, and tube formation of OGD-induced HBMECs.
genetics_overexpression_promote	34966429	hsa-mir-23b	Colonic Neoplasms	Furthermore, miR-23b-3p overexpression hindered the growth of COAD cells in vivo.
genetics_overexpression_promote	34965835	hsa-mir-128	Heart Failure	Adeno-associated virus serotype 9 (AAV9)-mediated constructs with miR-128 or anti-miR-128 were generated and delivered to overexpression or blockade of miR-128 in vivo followed by HF induction with isoproterenol (ISO) or transverse aortic constriction (TAC).
other	34965618	hsa-mir-146a	Periodontal Diseases	Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls.
circulation_biomarker_diagnosis_up	34965271	hsa-mir-210	Acquired Immunodeficiency Syndrome	inoculated cell lines and in the serum of HIV
genetics_knock down_promote	34965215	hsa-mir-454	Nasopharyngeal Carcinoma	3p, is downregulated by LINC00839 knockdown in NPC cells.
lncRNA target	34965191	hsa-mir-653	Colonic Neoplasms	3p, partially offset the inhibitory effect of miR
other	34965090	hsa-mir-155	Triple Negative Breast Neoplasms	As a result, the polarization-resolved ECL sensor can detect miRNA-155 sensitively, which is related to triple-negative breast cancer.
other	34965027	hsa-mir-148a	Osteoarthritis	CMEVs are carriers of both TGFbeta and miR-148a, two essential regulators for maintaining chondrocyte homeostasis and protection against cartilage destruction.
lncRNA target	34964438	hsa-mir-20b	Non-alcoholic Fatty Liver Disease	CONCLUSIONS: Taken together, our results demonstrate that the novel MIR20B targets PPARA, plays a significant role in hepatic lipid metabolism, and present an opportunity for the development of novel therapeutics for NAFLD.
circulation_biomarker_diagnosis_ns	34964177	hsa-mir-29a	Diabetic Nephropathies	CONCLUSION: The expression of serum miR-29a was significantly associated with the occurrence and progression of DN and is expected to become a potential biomarker for the diagnosis of DN.
lncRNA target	34963484	hsa-mir-423	Diabetic Retinopathy	5p transcription during DR to promote angiogenesis via suppressing HIPK2 expression to disinhibit HIF1alpha/VEGF signaling.
circulation_biomarker_diagnosis_up	34963442	hsa-mir-1825	Colorectal Neoplasms	Two important upregulated miRNAs, namely hsa-miR-1246 and hsamiR- 1825, were overlapped in both tissue and serum samples of CRC and were investigated to target identification, followed by functional annotation and protein-protein interaction (PPI) study for the target genes through DAVID and STRING, respectively. CONCLUSION: This study suggested that hsa-miR-1246 and hsa-miR-1825, as overlapped upregulated tissue and circulating miRNAs, might have a vital role in the development of CRC, and their five hub target genes were identified.
circulation_biomarker_diagnosis_up	34963442	hsa-mir-1246	Colorectal Neoplasms	Two important upregulated miRNAs, namely hsa-miR-1246 and hsamiR- 1825, were overlapped in both tissue and serum samples of CRC and were investigated to target identification, followed by functional annotation and protein-protein interaction (PPI) study for the target genes through DAVID and STRING, respectively. CONCLUSION: This study suggested that hsa-miR-1246 and hsa-miR-1825, as overlapped upregulated tissue and circulating miRNAs, might have a vital role in the development of CRC, and their five hub target genes were identified.
circulation_biomarker_diagnosis_ns	34963440	hsa-mir-20a	Pre-Eclampsia	This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia.
circulation_biomarker_diagnosis_ns	34963440	hsa-mir-424	Pre-Eclampsia	This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia.
circulation_biomarker_diagnosis_ns	34963440	hsa-mir-26a	Pre-Eclampsia	METHOD: Nine placental microRNAs (hsa-miR- 20a-5p, 21-3p, 26a-5p, 181a-5p, 199a-5p, 210-3p, 222-5p, 223-3p, 424-3p) were measured in maternal plasma during the second and third trimesters of normal pregnancies, using a SYBR Green-based real-time PCR, and compared the results against women affected by preeclampsia.
circulation_biomarker_diagnosis_ns	34963440	hsa-mir-199a	Pre-Eclampsia	This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia.
circulation_biomarker_diagnosis_ns	34963440	hsa-mir-21	Pre-Eclampsia	METHOD: Nine placental microRNAs (hsa-miR- 20a-5p, 21-3p, 26a-5p, 181a-5p, 199a-5p, 210-3p, 222-5p, 223-3p, 424-3p) were measured in maternal plasma during the second and third trimesters of normal pregnancies, using a SYBR Green-based real-time PCR, and compared the results against women affected by preeclampsia.
genetics_knock down_promote	34963405	hsa-mir-1236	Retinoblastoma	3p overexpression suppressed RB cell progression, with SMAD2 elevation abrogated the effect.
transcription factor target	34962394	hsa-mir-15b	Colitis	Most significantly, sweeteners can enhance the abundance of Mucispirillum and Alistipes, which are conducive to colitis recovery, and upregulate the expression of E-cadherin through the miR-15b/RECK/MMP-9 axis to improve intestinal barrier integrity.
lncRNA target	34962339	hsa-mir-210	Diabetic Retinopathy	This investigation aimed to determine whether gingerol plays a neuroprotective role in cerebral ischemia via the miR-210/BDNF axis.
target gene	34962153	hsa-mir-29a	Colorectal Neoplasms	Ginkgo biloba Extract Inhibited Cell Proliferation and Invasion by Stimulating TET2 Expression Through miR-29a in Colorectal Carcinoma Cells.
genetics_overexpression_promote	34962143	hsa-mir-28	Dry Eye Syndromes	Conclusion: Overexpression of miR-328 may contribute to DED.
lncRNA target	34962086	hsa-mir-124	Osteoporosis	In conclusion, lncRNA MALAT1 promoted the osteogenic differentiation of BMSCs and inhibited osteoclastic differentiation of M in osteoporosis via the miR3p/IGF2BP1/Wnt/-catenin axis.
other	34961772	hsa-mir-21	Breast Neoplasms	Among these miRNAs, miR-21 is known for its transcriptional upregulation in breast and numerous other cancers.
circRNA target	34961410	hsa-mir-377	Capsule Opacification	CONCLUSION: These results showed that circ-MKLN1 contributed to the progression of PCO in vitro by increasing the CTGF expression via sponging miR3p.
other	34961041	hsa-mir-99	Starvation	Here, we exposed Arabidopsis thaliana (Arabidopsis) transformant lines which harbor molecular modifications to the miR396 and miR399 expression modules to phosphate (PO(4)) starvation. We show that molecular alteration of either miR396 or miR399 abundance afforded the Arabidopsis transformant lines different degrees of tolerance to PO(4) starvation.
other	34961041	hsa-mir-96	Starvation	Here, we exposed Arabidopsis thaliana (Arabidopsis) transformant lines which harbor molecular modifications to the miR396 and miR399 expression modules to phosphate (PO(4)) starvation. We show that molecular alteration of either miR396 or miR399 abundance afforded the Arabidopsis transformant lines different degrees of tolerance to PO(4) starvation.
circulation_biomarker_diagnosis_ns	34959623	hsa-mir-145	Spermatic Cord Torsion	The biochemical analysis indicated that IR injury following T/D significantly decreased the activity of testicular glutathione peroxidase (GPx) enzyme, level of serum testosterone, serum inhibin B, and expression of testicular miRNA145, while increased the activity of testicular myeloperoxidase (MPO) enzyme, level of testicular malondialdehyde (MDA), level of serum antisperm-antibody (AsAb), and expression of ADAM-17. In conclusion, this study highlights the protective pharmacological application of vitamin D3 to ameliorate the damages of testicular T/D on the testicular tissues via targeting miRNA145 and ADAM17 protein.
exosome	34958869	hsa-mir-106a	Stomach Neoplasms	Tissue analysis verified the ectopic miR-106a expression in gastric cancer metastasis. CONCLUSION: Our data suggest that exosomal miR-106a facilitates gastric cancer peritoneal dissemination by integrating PMC to destroy mesothelial barrier.
lncRNA target	34958454	hsa-mir-137	Colonic Neoplasms	inhibited glutamine metabolism.
other	34958294	hsa-mir-17	Neointimal Hyperplasia	5p vs.
genetics_overexpression_promote	34958117	hsa-mir-485	Prostatic Neoplasms	3p overexpression suppressed the activity of TGF- signaling by targeting TGFBR2 to play tumor-suppressive roles in PC progression.
other	34958006	hsa-mir-335	Colorectal Neoplasms	Association of miR-21 and miR-335 to microsatellite instability and prognosis in BACKGROUND: MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors.
other	34958006	hsa-mir-21	Colorectal Neoplasms	Association of miR-21 and miR-335 to microsatellite instability and prognosis in BACKGROUND: MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors.
transcription factor target	34957997	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	5p and its target Ulk1.
other	34957995	hsa-mir-767	Carcinoma, Non-Small-Cell Lung	3p as a sponge.
genetics_knock down_suppress	34957935	hsa-mir-494	Precursor Cell Lymphoblastic Leukemia-Lymphoma	3p overexpression-induced anti-tumor influences were partly counteracted by the accumulation of NET1 in ALL cells.
lncRNA target	34957910	hsa-mir-21	Atrial Fibrillation	This showed that microRNA-1 and microRNA-21 were involved in the molecular remodeling of aging AF through the regulation of primers, which would provide a critical basis for diagnosis and treatment of aging AF.
lncRNA target	34957910	hsa-mir-1	Atrial Fibrillation	This showed that microRNA-1 and microRNA-21 were involved in the molecular remodeling of aging AF through the regulation of primers, which would provide a critical basis for diagnosis and treatment of aging AF.
circulation_biomarker_diagnosis_ns	34957382	hsa-mir-451a	COVID-19	Analysis of an independent cohort of 108 patients from a different center (Cohort 2) demonstrated feasibility of CC/miRNA profiling in leftover hospital blood samples with similar severe disease CC and miRNA profiles, and revealed CCL20, IL6, IL10, and miR-451a as key correlates of fatal COVID-19.
genetics_overexpression_promote	34957298	hsa-mir-149	Stomach Neoplasms	RESULTS: miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells.
other	34957214	hsa-mir-21	Incontinentia Pigmenti	In this study, we examined the expression levels of two human miRNAs (miRNA-122 and miRNA-21) in stool samples of a group of Bangladeshi children who had an altered/increased intestinal permeability (IIP). Results: The expression levels of miRNA-122 (fold change 11.6; p < 0.001, 95% CI: 6.14-11.01) and miR-21 (fold change 10; p < 0.001, 95% CI: 5.05-10.78) in stool were upregulated in children with IIP than in children with normal intestinal permeability (NIP).
other	34957214	hsa-mir-122	Incontinentia Pigmenti	In this study, we examined the expression levels of two human miRNAs (miRNA-122 and miRNA-21) in stool samples of a group of Bangladeshi children who had an altered/increased intestinal permeability (IIP). Results: The expression levels of miRNA-122 (fold change 11.6; p < 0.001, 95% CI: 6.14-11.01) and miR-21 (fold change 10; p < 0.001, 95% CI: 5.05-10.78) in stool were upregulated in children with IIP than in children with normal intestinal permeability (NIP).
genetics_knock down_promote	34957102	hsa-mir-940	Colorectal Neoplasms	Circ_0062682 knockdown suppressed CRC growth by decreasing PHGDH expression and serine production via miR-940.
epigenetics	34957096	hsa-mir-760	Osteosarcoma	Conclusion: Methylated DEGs may be involved in the development of OS, and the hsa_circ_0001753/has_miR_760/CD74 network may serve as a target for the early diagnosis of and targeted therapy for OS.
other	34956895	hsa-mir-410	Breast Neoplasms	The LINC00665-miR3p axis was identified as the most potential upstream ncRNA-related pathway of EMC2 in breast cancer.
target gene	34956884	hsa-mir-616	Urinary Bladder Neoplasms	miR-616-5p Promotes Invasion and Migration of Bladder Cancer via Downregulating NR2C2 Expression.
genetics_overexpression_promote	34956562	hsa-mir-141	Thyroid Neoplasms	Overexpression of BRD4 can partially reverse the restraining effect of miR
other	34956559	hsa-mir-29c	Alzheimer Disease	MiR-29c-3p has specific binding sites with the 3'-untranslated region (3'-UTR) of BACE1 and thus negatively regulates the BACE1 level, thereby affecting the progression of AD.
circulation_biomarker_diagnosis_up	34956523	hsa-mir-451	Infertility	Compared with normal people, miR-451 was abnormally low in endometriosis complicated with infertility tissues and cell lines (P&lt;0.001), while MIF was abnormally high (P&lt;0.001), and the miR-451 expression was dramatically down-regulated and the MIF expression was markedly up-regulated in serum of endometriosis patients complicated with infertility.
circulation_biomarker_diagnosis_up	34956523	hsa-mir-451	Endometriosis	Compared with normal people, miR-451 was abnormally low in endometriosis complicated with infertility tissues and cell lines (P&lt;0.001), while MIF was abnormally high (P&lt;0.001), and the miR-451 expression was dramatically down-regulated and the MIF expression was markedly up-regulated in serum of endometriosis patients complicated with infertility.
target gene	34956484	hsa-mir-103a	Carcinoma, Renal Cell	MiR-103a-3p aggravates renal cell carcinoma by targeting TMEM33.
lncRNA target	34956482	hsa-mir-199a	Urinary Bladder Neoplasms	Down-regulating linc00662 cinduced the expression of miR-199a-5p in BC and suppressed tumor growth.
circulation_biomarker_diagnosis_ns	34956481	hsa-mir-200a	Enterocolitis, Necrotizing	METHOD: The differentially expressed miRs in NEC were screened by analyzing GSE68054, and miR-200a-3p in IEC-6 cells induced by lipopolysaccharide (LPS) and serum of NEC children were detected by qRT-PCR.
other	34956462	hsa-mir-335	Meniscus Degeneration	RESULTS: We found that MUC13, inflammatory mediator regulation of TRP channels, MDFI, and miR5p may play a key role in the degenerative meniscus tissue.
genetics_GWAS	34956454	hsa-mir-433	Carcinoma, Non-Small-Cell Lung	The epigenetic silencing of microRNA-433 facilitates the malignant phenotypes of non-small cell lung cancer by targeting CREB1.
lncRNA target	34956453	hsa-mir-154	Osteosarcoma	Finally, rescue experiments determined that KCNQ1OT1 exerted major roles in OS through the miR
genetics_knock down_promote	34956421	hsa-mir-19b	Myocardial Infarction	Knockdown of miRNA-19b-3p decreased activities of LDH, MDA, and GSH-PX, but increased SOD level in H/R-induced HCM cells.
genetics_overexpression_promote	34956398	hsa-mir-381	Glioma	In this work, we confirmed that overexpressed miR
circulation_biomarker_diagnosis_ns	34956389	hsa-mir-19b	Infertility	In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well.
circulation_biomarker_diagnosis_ns	34956389	hsa-mir-28	Infertility	In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well.
other	34956389	hsa-mir-28	Infertility, Male	The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats.
circulation_biomarker_diagnosis_ns	34956389	hsa-mir-34	Infertility	In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well.
other	34956389	hsa-mir-34	Infertility, Male	The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats.
other	34956389	hsa-mir-19b	Infertility, Male	The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats.
other	34956365	hsa-mir-517c	Glioma	High levels of miR-296 and miR-517c can enhance chemosensitivity and serve as reliable indexes to predict the prognosis of patients with glioma.
transcription factor target	34956364	hsa-mir-137	Nasopharyngeal Neoplasms	In conclusion, our findings showed that miR-137 acted as a tumor suppressor gene in controlling NPC EMT and metastasis and that it may be a new therapeutic strategy and prognosis marker for the disease.
lncRNA target	34956213	hsa-mir-146a	COVID-19	Toll-like receptor 4 (TLR4) was inhibited in COVID-19 pneumonia by miR-146a-5p and upregulated in ARDS by let-7e-5p.
lncRNA target	34956213	hsa-let-7e	COVID-19	Toll-like receptor 4 (TLR4) was inhibited in COVID-19 pneumonia by miR-146a-5p and upregulated in ARDS by let-7e-5p.
genetics_overexpression_promote	34956209	hsa-mir-122	Osteoarthritis	In summary, our results suggest that IDO1 overexpression in the synovial fluid of OA patients impairs chondrogenic differentiation of MSCs and cartilage regeneration through downregulation of miR5p that activates the Wnt1/beta-catenin pathway.
other	34956196	hsa-mir-197	Multiple Sclerosis	To our knowledge, this would be the first report of a possible role of SNHG1/hsa-miR3p/YOD1/ZNF101 axes in the pathogenesis of MS.
circulation_biomarker_diagnosis_ns	34955881	hsa-mir-423	Bicuspid Aortic Valve Disease	CONCLUSION: Plasma exosomal miR5p regulated TGF-beta signaling by targeting SMAD2, thus exerting functions in the occurrence and development of BAV disease and its complication bicuspid aortopathy.
transcription factor target	34955743	hsa-mir-101	late onset Parkinson's disease	These results suggest that miR-101 regulates SEL1L expression and may serve as a new target for PD therapy.
lncRNA target	34955656	hsa-mir-3677	Adenocarcinoma of Lung	3p can promote LUAD progression by targeting KLF12.
circulation_biomarker_diagnosis_ns	34955516	hsa-let-7g	Alzheimer Disease	Previous evidence shows that miR-15b-5p, hsa-let7g-5p and hsa-let7d-5p might confer potential blood biomarkers for timely diagnosis of AD.
circulation_biomarker_diagnosis_ns	34955516	hsa-mir-15b	Alzheimer Disease	Evaluation of hsa-let-7d-5p, hsa-let-7g-5p and hsa-miR-15b-5p plasma levels in BACKGROUND: Alzheimer&#x27;s disease (AD) is a progressive neurodegenerative disorder MicroRNAs (miRNAs) may be promising diagnostic biomarkers for AD.
circulation_biomarker_diagnosis_ns	34955516	hsa-let-7d	Alzheimer Disease	Previous evidence shows that miR-15b-5p, hsa-let7g-5p and hsa-let7d-5p might confer potential blood biomarkers for timely diagnosis of AD.
other	34955008	hsa-let-7	Adenomyosis	OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis.
other	34955008	hsa-let-7	Endometriosis	In addition, a significant difference was noted regarding let-7 microRNA between the groups with and without endometriosis, as well as between the groups with more clinically and histologically severe and mild endometriosis.
other	34955008	hsa-mir-9	Endometriosis	OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis. RESULTS: Mann-Whitney analysis showed that the difference in mir-9 mRNA between the groups with and without endometriosis, as well as between the groups with more clinically and histologically severe and mild endometriosis, was statistically insignificant.
other	34955008	hsa-mir-9	Adenomyosis	OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis.
other	34954928	hsa-mir-623	Carcinoma, Hepatocellular	DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis.
other	34954928	hsa-mir-1272	Carcinoma, Hepatocellular	DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis.
other	34954928	hsa-mir-515	Carcinoma, Hepatocellular	DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis.
lncRNA target	34954927	hsa-mir-15a	Glioma	In addition, the luciferase activity of FAM66C was block by miR15a/miR15b, and the promotion of cell growth effects caused by FAM66C deficiency was attenuated by miR15a/miR15b mimics, further proved that FAM66C functioned as a competing endogenous RNA to regulate glioma growth via the miRNA/LATS1 signaling pathway.
lncRNA target	34954927	hsa-mir-15b	Glioma	In addition, the luciferase activity of FAM66C was block by miR15a/miR15b, and the promotion of cell growth effects caused by FAM66C deficiency was attenuated by miR15a/miR15b mimics, further proved that FAM66C functioned as a competing endogenous RNA to regulate glioma growth via the miRNA/LATS1 signaling pathway.
genetics_overexpression_promote	34954748	hsa-mir-181b	Angelman Syndrome	Circ_0002984 and VEGFA were overexpressed, and miR-181b-5p was downregulated in serum of AS patients and ox-LDL-stimulated VSMCs. Circ_0002984 downregulation suppressed cell proliferation and migration by regulating miR-181b-5p/VEGFA axis and phosphatidylinositol 3 kinase-AKT pathway in ox-LDL-stimulated VEGFA, providing a new mechanism for AS pathogenesis.
genetics_knock down_promote	34954694	hsa-mir-545	Colorectal Neoplasms	We found that TF overexpression blocked miR
other	34954656	hsa-mir-223	Periodontal Diseases	Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs.
other	34954656	hsa-mir-142	Periodontal Diseases	Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs.
other	34954656	hsa-mir-125a	Periodontal Diseases	Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs.
genetics_GWAS	34954153	hsa-mir-4440	Breast Neoplasms	CONCLUSION: CDKN2B-AS1 gene polymorphism might be related to the susceptibility of BC, CDKN2B-AS1 rs10965215 A/G genotype probably affect the proliferation, invasion and migration of BC cells by modulating the interactions with of miR-4440.
genetics_knock down_suppress	34953943	hsa-mir-29c	Inflammation	When the MIAT-specific short hairpin RNA and an miR-29c-3p inhibitor were cotransfected into cells, the inhibitor reversed the effects of MIAT knockdown on cell proliferation, apoptosis, inflammation, EMT, and collagen deposition.
other	34953943	hsa-mir-29c	Pulmonary Disease, Chronic Obstructive	Overall, these results indicate that MIAT participates in CS-induced EMT and airway remodeling in COPD by upregulating miR-29c-3p-HIF3A axis output, thereby offering a novel promising biomarker for the assessment of COPD exacerbation induced by CS exposure.
circulation_biomarker_diagnosis_up	34953918	hsa-mir-335	Esophageal Squamous Cell Carcinoma	RESULTS: Our expression studies showed a significantly decreased expression of tissue and circulating miR
transcription factor target	34953498	hsa-mir-216a	Stomach Neoplasms	miR-216a-5p was identified as a critical suppressor of FDFT1 expression and miR-216a-5p/FDFT1 axis regulated malignant behaviors and glycolysis of GC cells. GS suppressed malignant behaviors of GC by targeting miR-216a-5p/FDFT1 axis both in vitro and in vivo.
lncRNA target	34953475	hsa-mir-182	Nasal Polyps	induced EMT in response to TGF-beta1 might promote nasal polypogenesis in both Eos CRSwNP and non-Eos CRSwNP, thus providing potential targets for the future development of novel therapeutic approaches for the management of CRSwNP.
lncRNA target	34953475	hsa-mir-182	Nasopharyngitis	induced EMT in response to TGF-beta1 might promote nasal polypogenesis in both Eos CRSwNP and non-Eos CRSwNP, thus providing potential targets for the future development of novel therapeutic approaches for the management of CRSwNP.
genetics_GWAS	34953275	hsa-mir-6769b	Fetal Growth Retardation	Our findings imply that placental miR-6769b-5p may be used as an epigenetic marker for environmental pollutants-caused fetal growth restriction and its late-onset chronic diseases.
genetics_knock down_promote	34953057	hsa-mir-192	Lung Neoplasms	In vitro loss- and gain-of-function studies were performed to reveal the biological function of miR-192 and related mechanism of the microRNA-192/NKRF axis in lung cancer cell cisplatin resistance.
genetics_overexpression_promote	34953047	hsa-mir-223	Breast Neoplasms	In addition, overexpressed miR
circulation_biomarker_diagnosis_ns	34952998	hsa-mir-146a	psoriasis 1	METHODS: Plasma samples were collected from 84 moderate-to-severe psoriasis patients who underwent etanercept treatment (at baseline (M0), 1 month (M1), 3 months (M3), and 6 months (M6)), 80 disease controls and 80 health controls (both after enrollment); afterward, miR-146a and miR-146b expressions were detected by RT-qPCR.
circulation_biomarker_diagnosis_ns	34952998	hsa-mir-146b	psoriasis 1	METHODS: Plasma samples were collected from 84 moderate-to-severe psoriasis patients who underwent etanercept treatment (at baseline (M0), 1 month (M1), 3 months (M3), and 6 months (M6)), 80 disease controls and 80 health controls (both after enrollment); afterward, miR-146a and miR-146b expressions were detected by RT-qPCR.
lncRNA target	34952600	hsa-mir-944	Breast Neoplasms	Notably, BC patients with high expression of HNRNPC and low expression of hsa-miR-944 were correlated with late clinical stages and shorter survival times. Moreover, the circBACH2 (hsa_circ_0001625) was confirmed to act as hsa-miR-944 sponge to stimulate HNRNPC expression to promote BC cell proliferation via MAPK signaling pathway, thus constructing a circBACH2/hsa-miR-944/HNRNPC axis in BC.
exosome	34952333	hsa-mir-195	Osteosarcoma	Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo.
lncRNA target	34952204	hsa-mir-142	Tongue Neoplasms	5p inhibition substantially reversed the effects of PTTG3P silencing.
circulation_biomarker_diagnosis_ns	34951996	hsa-mir-196a	Nasopharyngeal Carcinoma	Moreover, we demonstrate an enrichment of miR196a-5p in the plasmatic EVs of NPC patients.
genetics_knock down_promote	34951563	hsa-mir-1270	Carcinoma, Hepatocellular	Contrarily, exhausting miR-1270 and restoring COL4A1 could severally abrogate the tumor-suppressive roles of circ_0088364 knockdown and miR-1270 overexpression in HCC cells in vitro.
circulation_biomarker_diagnosis_ns	34951407	hsa-mir-125b	Atherosclerosis	Our results suggest that circulating miR-34a, miR-125b and miR-221 levels can be used as novel biomarkers for detection of atherosclerosis by targeting NRF2.
circulation_biomarker_diagnosis_ns	34951407	hsa-mir-221	Atherosclerosis	Our results suggest that circulating miR-34a, miR-125b and miR-221 levels can be used as novel biomarkers for detection of atherosclerosis by targeting NRF2.
lncRNA target	34951340	hsa-mir-181a	Breast Neoplasms	In conclusion, miR-181a-5p facilitated tumor progression through NDRG2-induced activation of PTEN/AKT signaling pathway of breast cancer, suggesting that focusing on miR-181a-5p may provide new insight for breast cancer therapy.Abbreviations Brdu: Bromodeoxyuridine; CCK-8: Cell Counting Kit-8; miRNA: microRNAs; mut: mutant; RT-qPCR: real-time quantitative polymerase chain reaction; UTR: untranslated region; WT: wild-type.
lncRNA target	34951337	hsa-mir-410	Cardiomegaly	3p mediated Ang II-induced cardiac hypertrophy via targeting inhibition of Smad7.
genetics_overexpression_suppress	34951005	hsa-mir-490	Stomach Neoplasms	3p restrained proliferation, migration, invasion and stimulated apoptosis of GC cells, which was attenuated by overexpression of AURKA.
lncRNA target	34950770	hsa-mir-376c	Thyroid Cancer, Papillary	In conclusion, LINC00475 promotes PTC cell proliferation, migration, and invasion by upregulating ZCCHC12 via the interaction with miR-376c-3p.
lncRNA target	34950682	hsa-mir-182	Liver Diseases, Alcoholic	5p significantly increases lipid accumulation in ALD by targeting FOXO1, thereby providing novel scientific insights and potential therapeutic targets for ALD.
other	34950658	hsa-mir-587	Glioblastoma	By performing dual-luciferase reporter gene and RNA pull-down assays, we verified that circRFX3 could sponge microRNA-587 (miR-587) to exercise its function as a competing endogenous RNA (ceRNA) in the development of GBM. In conclusion, circRFX3 could act as a cancer-promoting circRNA to boost the development of GBM and regulate the miR-587/PDIA3/beta-catenin axis.
other	34950596	hsa-mir-98	Endometrial Neoplasms	The purpose of this research is to determine whether MRP-7 has a role in mediating the sensitivity of EC cells to paclitaxel and whether the expression of MRP-7 is regulated by miR-98 and lncRNA NEAT1. Taken together, these findings demonstrate that upregulation of MRP-7 and NEAT1, and downregulation of miR-98 have important roles in conferring paclitaxel resistance to EC cells.
circulation_biomarker_diagnosis_ns	34950438	hsa-mir-21	Pancreatitis	To explore the role of circulating blood miR-155 and miR-21 in promoting acute pancreatitis (AP) and evaluating the risk stratification of pancreatitis.
circulation_biomarker_diagnosis_ns	34950438	hsa-mir-155	Pancreatitis	To explore the role of circulating blood miR-155 and miR-21 in promoting acute pancreatitis (AP) and evaluating the risk stratification of pancreatitis.
genetics_overexpression_promote	34950224	hsa-mir-138	Osteosarcoma	RESULTS: Compared with that of the control group, the expression of miR-138 in PBMC and CD4+CXCR5+ Tfh cells of the OS group was lower; overexpression of miR-138 could promote the maturation of Tfh cells and immature B cells.
genetics_overexpression_promote	34950209	hsa-mir-33a	Breast Neoplasms	Moreover, overexpression of GRM8 abrogated the inhibitive role of miR-33a-5p played in breast cancer.
target gene	34950208	hsa-mir-1252	Stomach Neoplasms	circABCB10 can promote the proliferation, invasion, and clonal formation of gastric cancer cells by targeting miR-1252-5p and upregulating the expression of MYC.
lncRNA target	34950131	hsa-mir-10	White Spot Syndrome Virus  Infection	Functional analysis validated that miR-10c could target LvToll3 to inhibit its expression, through which miR-10c blocked the nuclear translocation of IRF and facilitated white spot syndrome virus (WSSV) infection.
lncRNA target	34950131	hsa-mir-10c	White Spot Syndrome Virus  Infection	Functional analysis validated that miR-10c could target LvToll3 to inhibit its expression, through which miR-10c blocked the nuclear translocation of IRF and facilitated white spot syndrome virus (WSSV) infection.
lncRNA target	34949180	hsa-let-7a	Ovarian Neoplasms	In this study, a novel nano targeted co-delivery system modified by hyaluronic acid (HA) was developed by using gold nanorods coated with functionalized mesoporous silica nanoparticles (HA-PTX/let-7a-GNR@MSN) for combined delivery of hydrophobic chemotherapy drug Paclitaxel (PTX) and lethal-7a (let-7a), a microRNA (miR), to overcome MDR in ovarian cancer.
lncRNA target	34949159	hsa-mir-1245b	Osteosarcoma	In conclusion, the HCG11/miR-1245b-5p/PKP2 axis promotes OS expression by promoting cell proliferation, migration, and invasion, and inhibiting apoptosis.
lncRNA target	34948431	hsa-mir-216a	Colonic Neoplasms	This study supports the miR-216a/GDF15 axis as a diagnostic/prognostic panel for COAD, identifies Th1, Treg, eosinophils, and NKTs as counteracting factors, indicates potential relationships underlying immunomodulation, mitochondrial organization, apoptotic signaling, and ER stress and unveil Gemcitabine as a potential drug for the development of treatment strategy when combined with targeting GDF15.
other	34948417	hsa-mir-1290	Pancreatic Carcinoma	We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs.
other	34948417	hsa-mir-10b	Pancreatic Carcinoma	We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs.
other	34948417	hsa-mir-429	Pancreatic Carcinoma	We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs.
other	34948417	hsa-mir-155	Pancreatic Carcinoma	We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs.
other	34948417	hsa-mir-16	Pancreatic Carcinoma	We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs.
other	34948403	hsa-mir-361	Diabetic Retinopathy	Case studies performed on diabetic retinopathy and hsa-mir-361 also validated the accuracy of our model.
genetics_GWAS	34948154	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	erlotinib regimen is more effective than the selumetinib-erlotinib combination in KRAS-mutated NSCLC.
circulation_biomarker_diagnosis_up	34947913	hsa-mir-146a	Arthritis, Rheumatoid	Serum was used to detect the relative expression levels of lnc-PVT1 and miR-146a and we correlated the levels with RA and OA activity and severity signs.
other	34946964	hsa-mir-222	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-497	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-21	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-1	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-93	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-155	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-29a	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-19b	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-451a	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-133a	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-221	Cardiomyopathy, Hypertrophic	5p, were considered.
other	34946964	hsa-mir-199a	Cardiomyopathy, Hypertrophic	5p, were considered.
lncRNA target	34946880	hsa-mir-138	Melanoma	5p Suppresses Cell Growth and Migration in Melanoma by Targeting Recent evidence suggests the existence of a miRNA regulatory network involving human telomerase reverse transcriptase gene (hTERT), with miR
lncRNA target	34946859	hsa-mir-199a	Squamous Cell Carcinoma of Head and Neck	Our in silico analysis and luciferase reporter assay identified paxillin (PXN) as a direct target of both miR
lncRNA target	34946859	hsa-mir-199b	Squamous Cell Carcinoma of Head and Neck	Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma (HNSCC).
circulation_biomarker_diagnosis_ns	34946826	hsa-mir-20a	Sepsis	The present study proposes to legitimize in sepsis a characteristic found in platelets that suffer storage lesions in blood banks, which is the increased expression of miRNA miR-320a in relation to miR-127.
circulation_biomarker_diagnosis_ns	34946826	hsa-mir-127	Sepsis	The present study proposes to legitimize in sepsis a characteristic found in platelets that suffer storage lesions in blood banks, which is the increased expression of miRNA miR-320a in relation to miR-127.
epigenetics	34946098	hsa-mir-145	Epstein-Barr Virus Infections	Therefore, EBV alone or jointly with HPV is associated with down-regulation of miR-145 and may influence on miR-145 promoter methylation through the induction of DNMT3B in OSCC.
epigenetics	34946098	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	Therefore, EBV alone or jointly with HPV is associated with down-regulation of miR-145 and may influence on miR-145 promoter methylation through the induction of DNMT3B in OSCC.
exosome	34945712	hsa-mir-335	Multiple Myeloma	miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells.
circulation_biomarker_diagnosis_ns	34945431	hsa-mir-17	Colorectal Neoplasms	3p in the blood plasma of a patient diagnosed with colorectal cancer has been demonstrated.
circulation_biomarker_diagnosis_up	34945242	hsa-let-7c	Infertility	The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control.
circulation_biomarker_diagnosis_up	34945242	hsa-let-7b	Infertility	The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control.
circulation_biomarker_diagnosis_up	34945242	hsa-let-7a	Infertility	The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control.
circulation_biomarker_diagnosis_up	34945242	hsa-mir-518f	Infertility	The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control.
other	34944897	hsa-mir-3687	Prostatic Neoplasms, Castration-Resistant	The RNA biomarkers: KLK3 mRNA, miR-375, miR-3687, and NAALADL2-AS2 were measured in 93 patients with mCRPC, before and 1 month after start of first-line abiraterone acetate or enzalutamide treatment, in two prospective clinical trials.
other	34944897	hsa-mir-375	Prostatic Neoplasms, Castration-Resistant	The RNA biomarkers: KLK3 mRNA, miR-375, miR-3687, and NAALADL2-AS2 were measured in 93 patients with mCRPC, before and 1 month after start of first-line abiraterone acetate or enzalutamide treatment, in two prospective clinical trials.
target gene	34944877	hsa-mir-335	Ovarian Neoplasms	miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1.
exosome	34944871	hsa-mir-150	Lung Neoplasms	We revealed CD226 downregulation and functional repression of NK cells after hypoxic lung cancer priming and we then investigated their interaction with extracellular vesicles (EVs) and miR5p.
target gene	34944818	hsa-mir-210	Pancreatic Neoplasms	Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma.
genetics_knock down_promote	34944742	hsa-mir-6315	Bone Diseases	Currently, microRNAs (miRNAs) are emerging as vital mediators involved in bone/bone marrow fat homeostasis and our previous studies have demonstrated that miR-6315 was upregulated in bones of MTX-treated rats, which might be associated with bone/fat imbalance by directly targeting Smad2. Our findings indicated that miR-6315 may be important in regulating osteogenesis and adipogenesis and might be a therapeutic target for preventing/attenuating MTX treatment-associated bone loss and marrow adiposity.
other	34944712	hsa-mir-154	Squamous Cell Carcinoma of Head and Neck	The implementation of miR-154 as a biomarker may improve the effectiveness of HNSCC treatment.
lncRNA target	34944699	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	The aim of the study here was to further investigate the tumor-suppressive roles of miR
transcription factor target	34944582	hsa-mir-22	Liver Cirrhosis	The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively.
transcription factor target	34944582	hsa-mir-219a	Liver Cirrhosis	The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively.
transcription factor target	34944582	hsa-mir-29c	Liver Cirrhosis	The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively.
circulation_biomarker_diagnosis_ns	34944567	hsa-mir-181a	Liver Cirrhosis	The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone.
circulation_biomarker_diagnosis_ns	34944567	hsa-mir-181a	Non-alcoholic Fatty Liver Disease	The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone.
other	34944497	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	The present study aimed to clarify the role of miR-34a in the EMT-related phenotypes of human non-small cell lung cancer (NSCLC) cell lines, A549 (p53 wild-type) and H1299 (p53-deficient). CONCLUSION: These findings indicate a close relationship between p53 and miR-34a-induced EMT in p53-wild type NSCLC cells, which provides novel insights about the role of miR-34a in EMT-like phenotypic changes in NSCLC.
circulation_biomarker_diagnosis_ns	34944484	hsa-let-7c	Hypertension	METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR
circulation_biomarker_diagnosis_ns	34944484	hsa-let-7c	Plaque, Atherosclerotic	METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR
circulation_biomarker_diagnosis_ns	34944484	hsa-mir-145	Plaque, Atherosclerotic	METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR
circulation_biomarker_diagnosis_ns	34944484	hsa-mir-145	Hypertension	METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR
other	34944116	hsa-mir-202	Anovulation	On the other hand, the mir3p expression profile reflected levels of oocyte maturation molecular markers (star, lhr) and both histological and molecular (casp3) levels of follicular atresia.
other	34944037	hsa-mir-497	Atrophy	5p is likely involved in a compensatory mechanism of muscle atrophy in response to IL-6.
other	34944012	hsa-mir-139	COVID-19	Using expression data from an independent study, we validated and identified two high-confidence miRNAs, namely, hsa-miR-30a-3p and hsa-miR5p, which have putative causal effects on developing cases of severe COVID-19.
other	34943987	hsa-mir-16	Alzheimer Disease	A meta-analysis, whenever possible, revealed miR3p and miR-16 as consistently downregulated in late-stage AD across the literature.
other	34943987	hsa-mir-132	Alzheimer Disease	A meta-analysis, whenever possible, revealed miR3p and miR-16 as consistently downregulated in late-stage AD across the literature.
other	34943807	hsa-mir-24	Endometritis	3p could give a therapeutic option for endometritis and other disorders commonly associated with endometritis, suggesting a novel avenue for endometritis treatment.
genetics_overexpression_suppress	34942624	hsa-mir-181a	Asthma	CONCLUSION: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma.
genetics_overexpression_suppress	34942624	hsa-mir-181a	Rhinitis, Allergic	CONCLUSION: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma.
lncRNA target	34942272	hsa-mir-21	Fluorosis, Dental	5p might be a potential therapeutic target for skeletal fluorosis.
genetics_overexpression_promote	34942190	hsa-mir-204	Venous Thrombosis	5p overexpression lentivirus plasmid were injected into the DVT rat model.
other	34941030	hsa-mir-208	Myocardial Infarction, Acute	Mir-208 had a highly effective diagnostic capacity to distinguish AMI from chest pain patients with an AUC of 93%. MiR-208 was sufficient to distinguish AMI patients with chest pain from healthy controls.
lncRNA target	34939978	hsa-mir-532	Squamous Cell Carcinoma of Head and Neck	3p could inhibit cell proliferation viability, adhesion, and migration in TSCC.
genetics_knock down_promote	34939762	hsa-mir-582	Carcinoma, Non-Small-Cell Lung	3p overexpression or knockdown of RGMB remarkably reversed the malignant phenotypes of NSCLC cells induced by the up-regulation of circ_0001073 expression.
other	34939761	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	Restoration of MiR-34a Expression by 5-Azacytidine Augments Alimta -Induced Cell Death in Non-Small Lung Cancer Cells by Downregulation of HMG B1, A2 and Bcl-2 Pathway.
other	34939557	hsa-mir-200a	Dengue	p.
other	34939557	hsa-mir-590	Dengue	p.
other	34939557	hsa-mir-101	Dengue	p.
other	34939557	hsa-mir-34a	Dengue	p.
other	34939557	hsa-mir-363	Dengue	p.
other	34939557	hsa-mir-9	Dengue	p.
other	34939557	hsa-mir-374a	Dengue	p.
transcription factor target	34939145	hsa-mir-122	Reperfusion Injury	Furthermore, the inhibition of miRNA-122 suppressed the IR injury-induced activation of the TLR signaling pathway. Of these, miRNA-122 promoted IR injury following LT, whereas its inhibition prevented IR injury in a TLR-dependent manner.
lncRNA target	34938603	hsa-mir-129	Glioma	5P), which partially alleviated the inhibitory effect of miR
circRNA target	34938599	hsa-mir-760	Abortion, Habitual	Furthermore, mechanistic dissection revealed that circRNA-DURSA exerts its effects by competitively binding to miR-760, which post-transcriptionally targets HIST1H2BE. These results reveal the regulatory roles of circRNA-DURSA in trophoblasts and identified a distinct circRNA-DURSA/miR-760/HIST1H2BE axis as potentially important diagnostic and therapeutic targets for URSA treatment.
lncRNA target	34938598	hsa-mir-4470	Colorectal Neoplasms	Data from mechanism assays revealed that circPTEN could elevate PTEN expression through sequestering microRNA-4470 (miR-4470) in CRC cells.
genetics_overexpression_promote	34938358	hsa-mir-144	Thyroid Neoplasms	5p inhibited ITGA3 expression in TC, and its overexpression remarkably reversed the tumor-promoting effects of overexpressed ITGA3 on the biological functions of TC.
genetics_GWAS	34938351	hsa-mir-107	Schizophrenia	rs1625579 within miR-137, rs6577555 within miR-34, and rs2296616 within miR-107 were sequenced in 150 cases and 150 controls to check the potential association between the SNPs and SCZ.
genetics_GWAS	34938351	hsa-mir-137	Schizophrenia	rs1625579 within miR-137, rs6577555 within miR-34, and rs2296616 within miR-107 were sequenced in 150 cases and 150 controls to check the potential association between the SNPs and SCZ.
other	34938350	hsa-mir-298	Atrial Fibrillation	In conclusion, our data find that circFAT1(e2) sponges miR-298 and then regulates MYB expression, thus affecting atrial fibrillation progression.
other	34938320	hsa-mir-429	Kidney Calculi	Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis.
other	34938320	hsa-mir-139	Kidney Calculi	Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis.
other	34938320	hsa-mir-23b	Kidney Calculi	Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis.
other	34938314	hsa-mir-103	Endomyocardial Fibrosis	CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process.
other	34938314	hsa-mir-29a	Endomyocardial Fibrosis	CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process.
other	34938314	hsa-mir-23a	Endomyocardial Fibrosis	CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process.
other	34938314	hsa-mir-127	Endomyocardial Fibrosis	CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process.
other	34938314	hsa-mir-149	Endomyocardial Fibrosis	CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process.
transcription factor target	34938197	hsa-mir-184	Dementia, Vascular	5p in OGD-injured cells, in line with the improved cell viability.
transcription factor target	34938197	hsa-mir-6875	Dementia, Vascular	5p in OGD-injured cells, in line with the improved cell viability.
other	34938191	hsa-mir-184	Diabetic Nephropathies, Proliferative	3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration.
other	34938191	hsa-mir-197	Diabetic Nephropathies, Proliferative	3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration.
other	34938191	hsa-mir-24	Diabetic Nephropathies, Proliferative	3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration.
exosome	34938180	hsa-mir-29	Pulmonary Fibrosis	loaded exosomes for PF treatment.
target gene	34938121	hsa-mir-421	Stomach Neoplasms	LncRNA FENDRR Inhibits Gastric Cancer Cell Proliferation and Invasion via the miR-421/SIRT3/Notch-1 Axis.
lncRNA target	34938119	hsa-mir-940	Nasopharyngeal Carcinoma	3/KPNA2 axis is pro-oncogenic in NPC progression, uncovering novel insights into targeted therapy for this disorder.
other	34938111	hsa-mir-449c	Cleft Palate	qRT-PCR results revealed significantly lower expression levels of lncRNA USP17L6P and c-Myc in NSCL/P tissues, while the expression level of hsa-miR-449c-5p was higher as compared to control samples (p < 0.05).
other	34938111	hsa-mir-449c	Cleft Palate, Non-Syndromic	qRT-PCR results revealed significantly lower expression levels of lncRNA USP17L6P and c-Myc in NSCL/P tissues, while the expression level of hsa-miR-449c-5p was higher as compared to control samples (p < 0.05).
lncRNA target	34937878	hsa-mir-138	Colorectal Neoplasms	In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines.
lncRNA target	34937878	hsa-mir-138	Carcinoma, Hepatocellular	In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines.
other	34937832	hsa-mir-195	Diabetic Retinopathy	In OG, the mRNA and protein expression levels of miR-195 and BAX were high, whereas those of BCL-2 and SIRT1 were low.
lncRNA target	34937502	hsa-mir-18a	Osteoporosis	Upregulation of miR-18a-3p restrained the activity and expression of ALP in hBMSCs, inhibited the expression of RUNX2, OCN, and OPN, and inhibited calcium deposition.
lncRNA target	34937497	hsa-mir-338	Glioma	In conclusion, SNHG18 accelerates glioma progression via regulating the miR
circulation_biomarker_diagnosis_up	34936736	hsa-mir-27b	Colorectal Neoplasms	CONCLUSION: Exosomal miR-27b-3p secreted by EMT-CRC cells increases blood vessel permeability and facilitates the generation of CTCs.
lncRNA target	34936303	hsa-mir-556	Carcinoma, Hepatocellular	Propofol inhibited HCC cell proliferation and EMT progress via NORAD/miR3p/MIEN1 axis.
lncRNA target	34936297	hsa-mir-548k	Stomach Neoplasms	We confirmed that the HDAC3/lncRNA-LET/miR-548k signal axis mediated the occurrence and development of GC, and HDAC3 could be a novel therapeutic target for the treatments of GC.
other	34936294	hsa-mir-10b	Infarction, Middle Cerebral Artery	The oxygen-glucose deprivation (OGD) induced SH-SY5Y cell model and middle cerebral artery occlusion model (MCAO) rats were constructed to investigate the role of miR-10b-3p and underline the regulatory mechanism of miR-10b-3p/PDCD5 axis in cerebral I/R injury.
other	34936294	hsa-mir-10b	Reperfusion Injury	Previous studies have demonstrated that miR-10b-3p is significantly downregulated in rats after cerebral ischemia injury, and this study aimed to investigate the effect of miR-10b-3p in cerebral ischemia/reperfusion (I/R) injury.
genetics_overexpression_promote	34936294	hsa-mir-10b	Ischemic Stroke	MiR-10b-3p overexpression could efficiently inhibit cell viability and proliferation, induce apoptosis of OGD/R-induced SH-SY5Y cells in vitro, and attenuate cerebral I/R injury of MCAO rats in vivo.
genetics_overexpression_suppress	34936294	hsa-mir-10b	Brain Injuries	Silencing of PDCD5 showed similar effect to miR-10b-3p mimics, while PDCD5 overexpression significantly reversed the protective effects of miR-10b-3p mimics on cerebral I/R injury.
genetics_overexpression_suppress	34936294	hsa-mir-10b	Brain Ischemia	Silencing of PDCD5 showed similar effect to miR-10b-3p mimics, while PDCD5 overexpression significantly reversed the protective effects of miR-10b-3p mimics on cerebral I/R injury.
genetics_overexpression_promote	34936288	hsa-mir-494	Carcinoma, Non-Small-Cell Lung	In NSCLC cells, overexpression of PCAT29 led to down-regulated miR-494 and up-regulated PTEN.
transcription factor target	34936240	hsa-mir-21	Glioblastoma	In this work, a novel targeted antisense miRNA-21 oligonucleotide (ATMO-21) delivery system is developed for GBM treatment.
transcription factor target	34936021	hsa-mir-128	Acquired Immunodeficiency Syndrome	Integrating SEV proteome and miRNAome revealed a significant decrease in the enrichment of disease-associated, brain-enriched, and HIV-associated miR3p (miR-128) in HIV COC SEV with a concomitant increase in miR-128 targets-PEAK1 and RND3/RhoE.
lncRNA target	34935899	hsa-mir-495	Triple Negative Breast Neoplasms	3p mimics could down-regulate GRP78 expression via the p-AKT/mTOR signaling pathway in TNBC cells.
other	34935307	hsa-mir-4729	Diabetic Retinopathy	CONCLUSIONS: The present study showed that ATP2B1-AS1 acted as a miR-4729 sponge to regulate IQGAP2 reducing high-glucose-induced endothelial dysfunction in DR.
transcription factor target	34935255	hsa-mir-3	Fatty Liver	Interestingly, the relative abundance of miR-33 in goose fatty liver was significantly higher than that in normal liver, while the relative mRNA and protein abundances of CROT, the target gene of miR-33, in goose fatty liver were significantly lower than those in goose normal liver. Taken together, these findings suggest that miR-33 mediates glucose promotion of lipid accumulation in goose primary liver cells, and that glucose participates in formation of goose fatty liver by regulating the expression of miR-33/CROT.
other	34935248	hsa-mir-1299	Hemoglobin Bart'S Hydrops   Fetalis Syndrome	Downregulations of hsa-miR-1299 and hsa-miR5p in ceRNA network were also validated by RT-qPCR.
other	34935248	hsa-mir-625	Hemoglobin Bart'S Hydrops   Fetalis Syndrome	Downregulations of hsa-miR-1299 and hsa-miR5p in ceRNA network were also validated by RT-qPCR.
other	34935052	hsa-mir-182	Benign Paroxysmal Positional Vertigo	miR1825pbased therapy can influence the expression of ANG and BDNF, which demonstrates the potential for treating RNV diseases.
other	34935052	hsa-mir-182	Retroviridae Infections	miR1825pbased therapy can influence the expression of ANG and BDNF, which demonstrates the potential for treating RNV diseases.
other	34934837	hsa-mir-100	Colorectal Neoplasms	For miRNA cargo, we previously showed that when compared to isogenic colorectal cancer (CRC) cells expressing wild-type KRAS, a distinct subset of miRNAs are differentially enriched in EVs from KRAS mutant active CRC cells, with miR-100 being one of the most enriched.
circulation_biomarker_diagnosis_up	34934442	hsa-mir-208a	Coronary Disease	Bioinformatics analysis and dual-luciferase reporter assays indicated that B-cell translocation gene 1 (BTG1) was a direct target gene of miR-208a-3p, and was downregulated in the peripheral blood samples of patients with CHD.
other	34934434	hsa-mir-499a	Kidney Failure, Chronic	The present study aimed to investigate the association of the miRNA-499a gene (MIR499A) A/G seed region variant (rs3746444) with DN-associated ESRD susceptibility in patients with diabetes mellitus, and to determine whether there was an association between the different genotypes and the patients' laboratory and clinical data.
other	34934434	hsa-mir-499a	Diabetes Mellitus, Type 2	The present study aimed to investigate the association of the miRNA-499a gene (MIR499A) A/G seed region variant (rs3746444) with DN-associated ESRD susceptibility in patients with diabetes mellitus, and to determine whether there was an association between the different genotypes and the patients' laboratory and clinical data.
lncRNA target	34934431	hsa-mir-609	Triple Negative Breast Neoplasms	Taken together, the results of the present study suggest that miR-3609 plays a vital role in mediating cell cycle arrest and inhibiting the proliferation of TNBC cells.
other	34934349	hsa-mir-124	Hypoplastic Left Heart Syndrome	3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS.
other	34934349	hsa-mir-191	Hypoplastic Left Heart Syndrome	3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS.
other	34934349	hsa-mir-155	Hypoplastic Left Heart Syndrome	3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS.
other	34934046	hsa-mir-1238	Carcinoma, Renal Cell	Our study thus provided evidence that the regulatory network involving circPPP6R3/miR3p/CD44 axis might provide promising biomarkers as well as a therapeutic approach for ccRCC.
lncRNA target	34933738	hsa-mir-103	Breast Neoplasms	This study aimed to evaluate the expression level of lncRNA-GAS5 and its target APOBEC3C in women with breast cancer through expression evaluation of miR-103. In conclusion, we observed down-regulation of APOBEC3C and LncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients.
lncRNA target	34933738	hsa-mir-103a	Breast Neoplasms	This study aimed to evaluate the expression level of lncRNA-GAS5 and its target APOBEC3C in women with breast cancer through expression evaluation of miR-103. In conclusion, we observed down-regulation of APOBEC3C and LncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients.
circulation_biomarker_diagnosis_up	34933711	hsa-mir-141	Hepatitis B	Receiver operating characteristic (ROC) curve analyses suggested that serum has mir141-5p and mir501-5p none significant diagnostic value for HBV infection.
circulation_biomarker_diagnosis_up	34933711	hsa-mir-501	Hepatitis B	Receiver operating characteristic (ROC) curve analyses suggested that serum has mir141-5p and mir501-5p none significant diagnostic value for HBV infection.
other	34933640	hsa-mir-20a	Osteoporosis	To investigate the role of MYC and miR320a in osteoporosis, MYC or miR-320a expression were knocked down in RAW 264.7 cells.
exosome	34933177	hsa-mir-24	Cardiomyopathies	3p from M2 macrophages-derived exosomes (M2-exo) could protect against myocardial injury after sepsis.
exosome	34933177	hsa-mir-24	Sepsis	3p from M2 macrophages-derived exosomes (M2-exo) could protect against myocardial injury after sepsis.
other	34932851	hsa-mir-24	Burns	3p is conducive to rehabilitating the denatured dermis, which may be beneficial in providing effective therapy of skin burns.
genetics_overexpression_suppress	34931960	hsa-mir-4709	Pulmonary Fibrosis	3p overexpression could advance obstructive renal fibrosis via LATS2 targeting in Hippo signaling pathway.
genetics_overexpression_promote	34931871	hsa-mir-539	Myocardial Infarction, Acute	Overexpression of miR
circulation_biomarker_diagnosis_up	34931755	hsa-mir-379	Parkinson Disease	The serum of patients with ischemic stroke and OGD-treated HCN-2 cells displayed a poor expression of miR
circulation_biomarker_diagnosis_up	34931755	hsa-mir-379	Brain Ischemia	The serum of patients with ischemic stroke and OGD-treated HCN-2 cells displayed a poor expression of miR
other	34931559	hsa-mir-335	Colorectal Neoplasms	Also, miR5p from the HgA signature was higher in AWD patients before surgery (Kruskal-Wallis test: p-value = 0.019).
other	34931559	hsa-mir-378a	Colorectal Neoplasms	RESULTS: Although the signatures did not predict recurrence, expression of the miRNAs from the CL signature decreased 1 year after surgery, and one miRNA of the signature, miR-378a-3p, almost reached significance in the NED subgroup (Wilcoxon signed-rank test: p-value = 0.078).
transcription factor target	34931339	hsa-mir-126	Skin Diseases	Our results revealed that decreased miR-126 in psoriatic CD4(+) T cells might accelerate the formation of skin lesions through promoting the differentiation of Th17 cells, thus suggesting a potential intervention target for psoriasis.
other	34931228	hsa-mir-21	Prostatic Neoplasms	This systematic review and meta-analysis suggests that elevated levels of miR-21 are associated with poor prognosis in PCa patients.
circRNA target	34930906	hsa-mir-541	Carcinoma, Hepatocellular	5p inhibitor suppressed tumor growth and reversed the effect of circMTO1 silencing on the promotion of tumor growth in HCC.
genetics_knock down_suppress	34930894	hsa-mir-93	Carcinoma, Pancreatic Ductal	5p, and its depletion resulted in reduced cell proliferation, invasion and migration, as observed in MYEOV-knockdown PDAC cells.
genetics_knock down_suppress	34930894	hsa-mir-17	Carcinoma, Pancreatic Ductal	5p, and its depletion resulted in reduced cell proliferation, invasion and migration, as observed in MYEOV-knockdown PDAC cells.
lncRNA target	34930676	hsa-mir-424	psoriasis 1	AGAP2-AS1 promotes keratinocyte proliferation through miR5p/AKT/mTOR axis and may be a promising target for psoriasis therapy.
genetics_knock down_promote	34930675	hsa-mir-486	Carcinoma, Squamous Cell, Cutaneous	Knockdown of FLOT2 promoted tumorigenesis of cSCC; whereas FLOT2 reversed the tumor-promoting effect of miR
genetics_knock down_promote	34930344	hsa-mir-338	Multiple Myeloma	3p inhibition reversed the antitumor effects of circ_0058058 knockdown on MM cell.
circRNA target	34930332	hsa-mir-516b	Osteosarcoma	CONCLUSION: Rg3 inhibited OS progression through circ_0003074/miR-516b-5p/KPNA4 axis, showing the potential of Rg3 as a therapeutic agent for OS.
transcription factor target	34930304	hsa-mir-6766	Liver Cirrhosis	These results also proposed a significant strategy that 3D-Exo could be used as natural nanoparticles to rescue liver injury via delivering antifibrotic miR3p.
genetics_overexpression_promote	34930287	hsa-mir-200a	Liver Injury	Rg3 could activate autophagy to improve mitochondrial dysfunction in LPS-treated hepatocytes, which was partially reversed by TUG1 depletion or miR-200a-3p overexpression.
genetics_overexpression_promote	34930169	hsa-mir-513c	Pre-Eclampsia	CONCLUSIONS: Our study reveals that overexpression of placenta miR-513c-5p is involved in PE by regulating the biological functions of trophoblasts through the inhibition of LRP6.
circRNA target	34929706	hsa-mir-205	Spinal Cord Injuries	CONCLUSION: Circ-Ctnnb1 promotes SCI through regulating Wnt/beta-catenin signaling via modulating the miR5p/Ctnnb1/Wnt2b axis.
other	34929656	hsa-mir-32	Brain Injuries, Traumatic	Symptom severity was significantly higher on the day of injury among mTBI subjects (p < 0.001), and miRNA 32-5p levels were also higher (p = 0.009).
other	34929287	hsa-mir-410	Colorectal Neoplasms	By confirming the regulatory relationship between miR3p and circMET, we propose a new mechanism for the observed sustained activation of MET in CRC.
genetics_overexpression_promote	34929233	hsa-mir-155	Cyprinid Herpesvirus 3	Overexpression of miR-155 effectively inhibited CyHV-3 replication in CCB cells and promoted type I interferon (IFN-I) expression.
genetics_knock down_promote	34929177	hsa-mir-146b	Fibrosis	In this process, the inhibition of PDGFRalpha in adipose tissue cells by miR-146b-5p may lead to the loss of their PDGFRalpha-induced profibrotic activities, thereby suppressing fibrosis.
lncRNA target	34927777	hsa-mir-17	Colorectal Neoplasms	Functionally, SOX4 triggered drug resistance of CRC cells to 5-FU through the miR-17/CYLD axis.
other	34927541	hsa-mir-195	Thyroid Cancer, Papillary	CircPVT1 could serve as a molecule sponge for miR-195 and mediate the ceRNA network to promote the expression of VEGFA, thus contributed to the malignant progression of PTC.
lncRNA target	34927513	hsa-mir-21	Inflammation	CONCLUSIONS: Quercetin could protect HNEpC cells against LPS-induced inflammatory injury via inducing miR-21/DMBT1/NF-kappaB axis.
exosome	34927445	hsa-mir-320c	Osteoarthritis	Conclusion: SMSC-derived exosomal miR-320c enhances chondrogenesis through targeting ADAM19, highlighting a potentially novel mechanism of SMSC in treating osteoarthritis.
circulation_biomarker_diagnosis_ns	34927407	hsa-mir-101	Retinitis	METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA
circulation_biomarker_diagnosis_ns	34927407	hsa-mir-101	Diabetes Mellitus, Type 1	METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA
circulation_biomarker_diagnosis_ns	34927407	hsa-mir-146	Diabetes Mellitus, Type 1	METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA
circulation_biomarker_diagnosis_ns	34927407	hsa-mir-146	Retinitis	METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA
genetics_overexpression_promote	34927228	hsa-mir-648	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The findings from the present study indicate that the overexpression of miR-3648 serves as a useful biomarker for the prediction of prognosis in NSCLC, and promotes tumor cell proliferation, migration and invasion.
other	34926963	hsa-mir-92a	Colorectal Neoplasms	Here, a ratiometric fluorescent biosensor based on the Forster resonance energy transfer between fluorophores is proposed for detecting colorectal cancer-specific miRNA (miR-92a-3p).
other	34926705	hsa-mir-3666	Urinary Bladder Neoplasms	Subsequently, we conducted bioinformatics analysis followed by RNA pull-down, ChIP, and luciferase reporter assays, from which we found that circRHOT1 expression in BC cells could be regulated by ZNF652, and circRHOT1 could promote SMAD5 expression to regulate BC cell cellular progression by sponging miR-3666.
other	34926693	hsa-mir-130a	Chronic Periodontitis	CONCLUSION: lncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR-130a is highly expressed.
other	34926687	hsa-mir-605	Stomach Neoplasms	We identified three lncRNAs (AC007785.3, AC079385.3, LINC01729), two miRNAs (miR-3174, miR-605), and clinical factors related to the pathogenesis and prognosis of GC.
other	34926670	hsa-mir-155	Hypertension, Renal	5p, which negatively regulates the expression of H2AC6.
lncRNA target	34926668	hsa-mir-1243	Hyperglycemia	RESULTS: The levels of circ_0008590 and RELB were increased in hRECs in hyperglycemia; during the progression of DR, the levels of circ_0008590 and RELB messenger RNA (mRNA) in aqueous humor were first decreased and then increased, whereas miR-1243 showed an opposite trend. CONCLUSIONS: In hyperglycemia, high expression of RELB/circ_0008590 could be suppressed by miR-1243, and the nuclear factor-kappaB (NF-kappaB) pathway is subsequently affected.
other	34926662	hsa-mir-155	Hepatitis C, Chronic	miR-155 regulates pro- and anti-inflammatory cytokine expression in human monocytes during chronic hepatitis C virus infection.
genetics_overexpression_promote	34926661	hsa-mir-155	Brain Injuries	Subsequently, this study was designed to investigate the potential role and mechanisms of BMAL1 in SBI following ICH using lentiviral overexpression and antagomir-155 treatments.
genetics_overexpression_promote	34926661	hsa-mir-155	Cerebral Hemorrhage	Subsequently, this study was designed to investigate the potential role and mechanisms of BMAL1 in SBI following ICH using lentiviral overexpression and antagomir-155 treatments.
other	34926294	hsa-mir-205	Cholangiocarcinoma	Quantitative real-time PCR (qRT-PCR) showed that expressions of CHRM3.AS2, MIR205HG, and LINC00661 were higher in CCA tissues than those in normal tissues, similar to the trends detected in the CCA dataset.
lncRNA target	34926237	hsa-mir-1246	Breast Neoplasms	Therefore, miR-1246 may promote drug resistance and metastasis in breast cancer by targeting NFE2L3.
genetics_knock down_suppress	34925694	hsa-mir-195	Adenocarcinoma of Lung	RESULTS: Both gain- and loss-of-function assays demonstrated that miR
genetics_knock down_promote	34925640	hsa-mir-637	Thyroid Cancer, Papillary	Moreover, circLDLR acted as a sponge for miR-637, and miR-637 interference reversed the anticancer effects of circLDLR knockdown on PTC cells.
lncRNA target	34925543	hsa-mir-181c	Intervertebral Disc Degeneration	RESULTS: hsa_circ_0001658 was significantly upregulated (logFC > 2.0 and adj.P.Val < 0.01) in the NP tissues of IDD patients, and hsa-miR-181c-5p expression was downregulated (logFC < -2.0 and adj.P.Val < 0.01). CONCLUSION: Circular RNA hsa_circ_0001658 inhibits IDD development by regulating hsa-miR-181c-5p/FAS.
target gene	34925523	hsa-mir-129	Prostatic Neoplasms	Breviscapine Participates in the Progression of Prostate Cancer by Inhibiting ZFP91 Expression through Upregulation of MicroRNA-129-5p.
other	34925506	hsa-mir-20a	Urinary Bladder Neoplasms	MiR-20a-5p Negatively Regulates NR4A3 to Promote Metastasis in Bladder Cancer.
genetics_overexpression_promote	34925225	hsa-mir-4739	Osteoporosis	In osteoporotic BMSCs, miR-4739 overexpression significantly inhibited cell viability, osteoblast differentiation, mineralized nodule formation, and heterotopic bone formation, whereas miR-4739 inhibition exerted opposite effects.
lncRNA target	34925023	hsa-mir-375	Cardiomegaly	In summary, our study demonstrates that OT ameliorates cardiac hypertrophy by inhibiting PI3K/AKT pathway via lncRNA GAS5/miR
other	34924755	hsa-mir-342	Stroke	CONCLUSION: In summary, lncRNA FTX enhanced the angiogenesis in stroke by acting as a sponge of miR3p to regulate the expression of SPI1 level.
genetics_overexpression_promote	34924500	hsa-mir-26b	Breast Neoplasms	Overexpression of miR-26b-5p also suppressed the tumorigenesis of chemoresistant BC cells in vivo.
genetics_knock down_promote	34924499	hsa-mir-489	Breast Neoplasms	CircCDK1 knockdown enhanced the sensitivity of Tamoxifen in breast cancer cells and suppressed cell growth and survival by depleting CDK1 expression via releasing miR- 489-3p.
transcription factor target	34924391	hsa-mir-195	Mitochondrial Diseases	BACKGROUND: Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD) and miR-195 is involved in mitochondrial disorder through targeting MFN-2 protein in hippocampal neurons of AD.
circulation_biomarker_diagnosis_up	34923944	hsa-mir-126	Intracranial Aneurysm	CONCLUSION: Our results indicated that circulating miR-126 in plasma samples could be served as a potential non-invasive biomarker in IAs detection and prevention IAs with a high risk of rupture.
other	34923910	hsa-mir-370	Atherosclerosis	Taken together, our results show that TMAO-NEAT1/miR3p/STAT3/FMO3 forms a positive feedback loop to exacerbate the development of AS.
circulation_biomarker_diagnosis_up	34923889	hsa-mir-218	Pre-Eclampsia	RESULTS: Compared with the PE group, 24-h urinary protein content, blood pressure, VEC apoptosis rate, apoptosis marker levels, and HMGB1 expression decreased while miR
lncRNA target	34923813	hsa-mir-200	Stomach Neoplasms	Taken together, the HOTAIR-miR-200 axis seems to play a vital role in human GC, suggesting a potential therapeutic target in future GC treatment.
genetics_overexpression_promote	34923485	hsa-mir-1246	Ovarian Neoplasms	Functionally, overexpression of miR-1246 markedly enhanced DDP resistance and cell proliferation, and suppressed cell cycle arrest and apoptosis of OC cells.
lncRNA target	34922601	hsa-mir-128	Breast Neoplasms	CONCLUSION: PVT1 may act as an oncogene in breast cancer through binding miR3p and UPF1 and represents a potential target for BC therapeutic development.
circulation_biomarker_diagnosis_up	34922585	hsa-mir-181b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: miRNA-181b-5p carried by EVs in peripheral blood of ALL patients can enter ALL cells and thus promote the malignancy of ALL cells.
lncRNA target	34922544	hsa-mir-761	Colorectal Neoplasms	Mechanistically, circIL4R was regulated by TFAP2C and competitively interacted with miR-761 to enhance the expression of TRIM29, thereby targeting PHLPP1 for ubiquitin-mediated degradation to activate the PI3K/AKT signaling pathway and consequently facilitate CRC progression.
other	34922539	hsa-mir-125a	Carcinoma, Renal Cell	CONCLUSIONS: We found that sponging of miR-125a-5p to promote EIF4EBP1 expression is the underlying mechanism of hsa_circ_0020303-induced ccRCC progression.
transcription factor target	34922523	hsa-mir-1245b	Premenstrual Syndrome	qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII.
transcription factor target	34922523	hsa-mir-4291	Premenstrual Syndrome	qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII.
other	34922523	hsa-mir-544a	Premenstrual Syndrome	However, contrary to the NGS results, qRT-PCR analysis showed decreased expression of miR544a in PMSII.
transcription factor target	34922523	hsa-mir-1825	Premenstrual Syndrome	qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII.
genetics_overexpression_promote	34922339	hsa-mir-345	Breast Neoplasms	Overexpression and inhibition of miR
genetics_knock down_promote	34922206	hsa-mir-513b	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Knockdown of circ_LPAR3 could inhibit the OSCC progression by sponging miR-513b-5p and activating VEGFC and AKT1.
transcription factor target	34921979	hsa-mir-155	Carcinoma, Renal Cell	Here we show that miR-155 directly targets FTO to negatively regulate its expression and increased m(6)A level in ccRCC.
other	34921595	hsa-mir-184	Carcinoma, Non-Small-Cell Lung	5p and EIF5A.
transcription factor target	34921586	hsa-mir-125b	Cardiotoxicity	This work aims to investigate the effects of miR-125b in Dox-induced cardiotoxicity. In conclusion, our study demonstrated that miR-125b could enhance Dox-induced cardiotoxicity through targeting the STARD13/YAP axis.
other	34921580	hsa-mir-15a	Neurodegenerative Diseases	Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.
other	34921580	hsa-mir-15b	Neurodegenerative Diseases	Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.
other	34921580	hsa-mir-16	Neurodegenerative Diseases	Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene.
lncRNA target	34921567	hsa-mir-125a	Parkinson Disease	BACKGROUND: This study aimed to investigate the correlation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) and its target microRNAs (microRNA-34a (miR-34a) and microRNA-125a (miR-125a)) with disease risk and severity of Parkinson's disease (PD).
lncRNA target	34921567	hsa-mir-34a	Parkinson Disease	BACKGROUND: This study aimed to investigate the correlation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) and its target microRNAs (microRNA-34a (miR-34a) and microRNA-125a (miR-125a)) with disease risk and severity of Parkinson's disease (PD).
other	34921525	hsa-mir-1	Breast Neoplasms	3p, OR: 1.39, 95% CI: 1.01-1.91).
other	34921525	hsa-mir-382	Breast Neoplasms	3p, OR: 1.39, 95% CI: 1.01-1.91).
other	34921177	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	PPAR and miR-17 may be markers differentiating tumour tissue from surgical margin and miR-17 may have diagnostic role in NSCLC histotypes differentiation.
lncRNA target	34921037	hsa-mir-183	Stomach Neoplasms	CONCLUSION: miR-183 can influence the proliferation, apoptosis and autophagy of GC cells through targeted inhibition of mTOR expression.
circulation_biomarker_prognosis_ns	34920681	hsa-mir-451	Atherosclerosis	RESULTS: The expression of miR-451a was significantly decreased in the serum of AS patients.
circulation_biomarker_prognosis_ns	34920681	hsa-mir-451a	Atherosclerosis	RESULTS: The expression of miR-451a was significantly decreased in the serum of AS patients.
genetics_GWAS	34920653	hsa-mir-125b	common variable immunodeficiency 2	Our results suggest that overexpression of miR-125b-5p affects the terminal differentiation of B cells in a selected group of CVID patients by downregulating the BLIMP-1 gene and more intensively for the IRF-4 gene expressions.
other	34920184	hsa-mir-374c	Breast Neoplasms	Together, these findings demonstrated that m6A modification of pri-miRNA-374c blocks miRNA-374c-5p maturation and then activates GRM3 expression, which drives BC cell metastasis after Cd exposure.
genetics_knock down_promote	34920123	hsa-mir-20a	Urinary Bladder Neoplasms	However, the function of miR-320a was opposite to that of TUG1, and miR-320a inhibitor partially eliminated the inhibitory effect of TUG1 knockdown on the malignant behavior of BC cells.
other	34919704	hsa-mir-1908	Diabetes Mellitus, Type 2	Finally, by integrating the miRNA-eQTLs and Japanese genome-wide association studies of 25 complex traits (mean n = 192833), we conducted a transcriptome-wide association study, identifying miR5p as a potential mediator for adult height, colorectal cancer and type 2 diabetes (P &lt; 9.1 10-5).
other	34919695	hsa-mir-146a	Muscular Atrophy, Spinal	However, miR-146a, known to be upregulated in SMA-induced pluripotent stem cell (iPSC)-derived astrocytes, showed increased expression in nusinersen-treated CSF samples. We then used mRNA sequencing and multi-electrode arrays to assess the transcriptional and functional effects of miR-146a on healthy and SMA iPSC-derived motor neurons.
transcription factor target	34919671	hsa-mir-1983	Metabolic Diseases	Our findings provide evidence for miR-1983 as a unique biomarker of cellular insulin resistance, and a potential therapeutic target for prevention of human metabolic disease.
circulation_biomarker_diagnosis_ns	34919671	hsa-mir-1983	Insulin Resistance	Importantly, we demonstrate that miR-1983 is detectable in human blood serum and that its levels significantly correlate with blood insulin and the homeostatic model assessment of insulin resistance. Our findings provide evidence for miR-1983 as a unique biomarker of cellular insulin resistance, and a potential therapeutic target for prevention of human metabolic disease.
genetics_overexpression_promote	34919276	hsa-mir-214	Multiple Myeloma	3p and miR-5100 overexpression increase MM cell proliferation and resistance to bortezomib-induced apoptosis by switching the balance between pro-/anti-apoptotic proteins.
genetics_overexpression_promote	34919276	hsa-mir-5100	Multiple Myeloma	3p and miR-5100 overexpression increase MM cell proliferation and resistance to bortezomib-induced apoptosis by switching the balance between pro-/anti-apoptotic proteins.
genetics_knock down_suppress	34919120	hsa-mir-183c	Keratitis	CONCLUSIONS: Prophylactic miR-183C knockdown is protective against PA keratitis through its regulation of innate immunity, corneal innervation, and neuroimmune interactions.
lncRNA target	34919034	hsa-mir-1205	Thyroid Cancer, Papillary	Circ_0000644 could directly interact with miR-1205 to repress the expression of miR-1205, and it served as a miR-1205 sponge to modulate E2F3 expression in PTC cells. Circ_0000644 up-regulates E2F3 expression via sponging miR-1205 to promote PTC progression.
circRNA target	34919024	hsa-mir-146b	Carcinoma, Non-Small-Cell Lung	Circ_0014235 downregulation reduced Gefitinib IC50, inhibited cell proliferation and induced cell apoptosis and cell cycle arrest in Gefitinib-resistant NSCLC cells, while these effects were reversed by the inhibition of miR-146b-5p, a target of circ_0014235. Circ_0014235 confers Gefitinib resistance and malignant behaviors in Gefitinib-resistant NSCLC by governing the miR-146b-5p/YAP/PD-L1 pathway.
lncRNA target	34919012	hsa-mir-606	Esophageal Squamous Cell Carcinoma	Our results indicate the oncogene role of circGOT1 in ESCC via an endogenous competition RNA (ceRNA) mechanism to promote GOT1 expression via sponging miR-606.
other	34918978	hsa-mir-143	Ventricular Dysfunction, Right	In this study, we aimed to estimate the association between miR-143/145 rs4705343 and the risk of CHD in a Chinese Tibetan population. Conclusion: The present study suggests that the rs4705343 CC genotype of miR-143/145 is associated with CHD risk in a Chinese Tibetan population.
other	34918978	hsa-mir-145	Ventricular Dysfunction, Right	In this study, we aimed to estimate the association between miR-143/145 rs4705343 and the risk of CHD in a Chinese Tibetan population. Conclusion: The present study suggests that the rs4705343 CC genotype of miR-143/145 is associated with CHD risk in a Chinese Tibetan population.
genetics_knock down_promote	34918962	hsa-mir-210	Hepatoblastoma	Knockdown of MIR210HG reduced proliferation, migration, and invasion in liver cancer cells, and suppressed tumor growth in vivo.
genetics_knock down_suppress	34918962	hsa-mir-608	Hepatoblastoma	CONCLUSION: Our study demonstrated that knockdown of MIR210HG inhibits hepatoblastoma development through binding to miR-608 and downregulating FOXO6. Our results provide novel insights for hepatoblastoma treatment involving the MIR210HG-miR608-FOXO6 axis.
lncRNA target	34918563	hsa-mir-133b	Carcinoma, Endometrioid	Conclusion: The findings from the present study suggested that miR-133b may be a tumor suppressor gene and a potential therapeutic target for the treatment of EC.
other	34917801	hsa-mir-106a	Alzheimer Disease	RESULTS: Among the 16 experimentally verified miRNAs, Network analysis of the LGMN and its associated miRNA identify novel hsa-miRNA-106a-5p and hsa-miRNA-34a-5p being more expressed in the brain.
other	34917801	hsa-mir-34a	Alzheimer Disease	RESULTS: Among the 16 experimentally verified miRNAs, Network analysis of the LGMN and its associated miRNA identify novel hsa-miRNA-106a-5p and hsa-miRNA-34a-5p being more expressed in the brain.
circulation_biomarker_diagnosis_up	34917685	hsa-mir-146a	Diabetes Mellitus, Type 2	The AUC cutoff values of circulating miRNAs, miR-146a and miR-144; myokines, adropin and irisin; and serum OPN were significantly identified by ROC analysis which additionally recommends the potential use of these biomarkers, miR-146a, miR-144, adropin, irisin, and OPN, as diagnostic biomarkers with considerable specificity and sensitivity for diabetes in patients with varying glycemic control status.
circulation_biomarker_diagnosis_up	34917685	hsa-mir-144	Diabetes Mellitus, Type 2	The AUC cutoff values of circulating miRNAs, miR-146a and miR-144; myokines, adropin and irisin; and serum OPN were significantly identified by ROC analysis which additionally recommends the potential use of these biomarkers, miR-146a, miR-144, adropin, irisin, and OPN, as diagnostic biomarkers with considerable specificity and sensitivity for diabetes in patients with varying glycemic control status.
circulation_biomarker_diagnosis_ns	34917657	hsa-mir-126a	Myocardial Reperfusion Injury	Mechanistically, RIPC-exosome, especially exosomal miR-126a-3p, activated the reperfusion injury salvage kinase (RISK) pathway by enhancing the phosphorylation of Akt and Erk1/2, and simultaneously inhibited Caspase-3 mediated apoptotic signaling. Conclusions: Our findings reveal a novel myocardial protective mechanism that plasma exosomes at the late phase of RIPC attenuate myocardial ischemia-reperfusion injury via exosomal miR-126a-3p.
other	34917535	hsa-mir-155	Nasopharyngeal Carcinoma	CONCLUSION: Taken together, miR-155 in NPC was upregulated.
lncRNA target	34917510	hsa-mir-326	Carcinoma, Hepatocellular	LMNB2 axis may be a potential therapeutic target for HCC.
circulation_biomarker_diagnosis_ns	34917199	hsa-mir-146	Hypertension, Pulmonary	30 patients with PAH and 20 healthy volunteers in our hospital were enrolled, and their serum samples were extracted for the detection of microRNA
other	34917156	hsa-mir-499	Cardiovascular Diseases	CONCLUSIONS: We proved that ferulic acid protects cardiomyocytes from oxidative stress-induced injury by regulating the miR5p/p21signaling pathway, which provides insight into the clinical application of ferulic acid in the treatment of cardiovascular diseases.
other	34917094	hsa-mir-155	Acquired Immunodeficiency Syndrome	We found that in PLWH-derived MDMs, pro-inflammatory signals (TNFA, IL6, IL1B, miR5p, and IDO1) dominate over negative feedback signals (NCOR2, GSN, MSC, BIN1, and miR-146a-5p), favoring an abnormally trained phenotype.
other	34917094	hsa-mir-146a	Acquired Immunodeficiency Syndrome	We found that in PLWH-derived MDMs, pro-inflammatory signals (TNFA, IL6, IL1B, miR5p, and IDO1) dominate over negative feedback signals (NCOR2, GSN, MSC, BIN1, and miR-146a-5p), favoring an abnormally trained phenotype.
transcription factor target	34916847	hsa-mir-1306	lung squamous cell carcinoma	CONCLUSION: miR-1306 functions as a prognostic indicator and tumor promoter of LUSC through targeting RBM3, which provides a potential therapeutic target of LUSC.
target gene	34916840	hsa-mir-659	Carcinoma, Non-Small-Cell Lung	β-Caryophyllene from Chilli Pepper Inhibits the Proliferation of Non-Small Cell Lung Cancer Cells by Affecting miR-659-3p-Targeted Sphingosine Kinase 1 (SphK1).
other	34916825	hsa-mir-6848	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-4739	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6751	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-365a	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-4754	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-1224	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-550b	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6878	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-4684	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6754	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-718	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-4786	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6739	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6795	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-6884	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916825	hsa-mir-550a	Burns	3p, hsa-miR-550a-3p, and hsa-miR-550b-3p).
other	34916611	hsa-mir-204	Chanarin-Dorfman Syndrome	The results show that GAS5 was up-regulated, whereas miR3p was down-regulated in anterior lens capsule tissues of DC patients and in HG-treated LECs compared to their controls, respectively.
genetics_overexpression_promote	34915882	hsa-mir-103a	Melanoma	The suppressive impact of TEX41 depletion on melanoma cell malignant behaviors could be counteracted by miR-103a-3p inhibition or C1QB overexpression. CONCLUSIONS: IRF4-activated TEX41 sequestered miR-103a-3p and modulated C1QB to promote melanoma cell malignant behaviors, for which TEX41 might be regarded as a potential therapeutic target for melanoma.
lncRNA target	34914969	hsa-mir-489	Reperfusion Injury, Cerebral Ischemia	3p obviously attenuated cerebral I/R injury by increasing PC12 cell viability, reducing LDH release, and inhibiting cell apoptosis.
transcription factor target	34914964	hsa-mir-195	Bicuspid Aortic Valve Disease	5p expression by binding its promoter region and partially promotes calcification through a SMAD-dependent pathway.
circulation_biomarker_diagnosis_ns	34914874	hsa-mir-26a	Triple Negative Breast Neoplasms	The MQD@Au NBs heterostructure-based ECL sensing system was applied to determine miRNA-26a in the serum of patients with triple-negative breast cancer.
circulation_biomarker_prognosis_up	34914790	hsa-mir-147b	Shock, Septic	CONCLUSIONS: The plasma miR-147b may be an useful biomarker independently or in combination with PCT to support clinical diagnosis of sepsis and equally prognosis of patients with septic shock.
lncRNA target	34914716	hsa-mir-20a	Colorectal Neoplasms	In summary, our study investigates the targetome of the TSS-miRNAs in colorectal cancer cells and establishes miR-320a as a regulator of unfolded protein response.
lncRNA target	34914251	hsa-mir-588	Hamartoma Syndrome, Multiple	5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells.
other	34914251	hsa-mir-138	Arrest of spermatogenesis	5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double.
lncRNA target	34914251	hsa-mir-138	Hamartoma Syndrome, Multiple	5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells.
other	34914251	hsa-mir-588	Arrest of spermatogenesis	5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double.
lncRNA target	34914251	hsa-mir-155	Hamartoma Syndrome, Multiple	5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells.
other	34914251	hsa-mir-155	Arrest of spermatogenesis	5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double.
other	34914251	hsa-mir-181d	Arrest of spermatogenesis	5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double.
lncRNA target	34914251	hsa-mir-181d	Hamartoma Syndrome, Multiple	5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells.
lncRNA target	34914251	hsa-mir-19a	Hamartoma Syndrome, Multiple	5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells.
other	34914251	hsa-mir-19a	Arrest of spermatogenesis	5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double.
circRNA target	34914211	hsa-mir-339	Prostatic Neoplasms	CONCLUSIONS: Hsa_circ_0005221 enhances the progression of prostate cancer through the miR
lncRNA target	34913989	hsa-mir-193b	Diabetes Mellitus, Type 2	CONCLUSIONS/INTERPRETATION: Our results identified a previously unrecognised role of miR-193b in muscle function and mass that could be a potential therapeutic target for treating sarcopenia.
other	34913774	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Additionally, we detected miR-21 with the maximum Sen of 0.74 [95%CI: 0.62-0.83], miR-146 with the maximum Spe and AUC of 0.93 [95%CI: 0.79-0.98] and 0.89 [95%CI: 0.86-0.92] for early-stage NSCLC. We also identified the diagnostic power of available panel (miR-210, miR-31 and miR-21) for NSCLC with satisfying Sen, Spe and AUC of 0.82 [95%CI: 0.78-0.84], 0.87 [95%CI: 0.84-0.89] and 0.91 [95%CI: 0.88-0.93], and furtherly constructed 2 models for better diagnosis.
other	34913774	hsa-mir-21	Lung Neoplasms	Additionally, we detected miR-21 with the maximum Sen of 0.74 [95%CI: 0.62-0.83], miR-146 with the maximum Spe and AUC of 0.93 [95%CI: 0.79-0.98] and 0.89 [95%CI: 0.86-0.92] for early-stage NSCLC. We also identified the diagnostic power of available panel (miR-210, miR-31 and miR-21) for NSCLC with satisfying Sen, Spe and AUC of 0.82 [95%CI: 0.78-0.84], 0.87 [95%CI: 0.84-0.89] and 0.91 [95%CI: 0.88-0.93], and furtherly constructed 2 models for better diagnosis.
other	34913724	hsa-mir-188	Diabetic Nephropathies	Possibly germacrone-based treatment for DN can be further motivated by regulating mmu_circRNA_0000309/miR3p/GPX4 signaling axis.
circRNA target	34913472	hsa-mir-766	Carcinoma, Squamous Cell, Cutaneous	3p/HOXA9 axis, which might provide a promising therapeutic target for CSCC.
circulation_biomarker_diagnosis_ns	34913274	hsa-mir-29a	Inflammation, Chronic	In summary, our work suggests that EV-associated miR-29a-3p plays a crucial role in MUD and might be used as a potential blood-based biomarker for detecting chronic inflammation and synaptic damage.
circulation_biomarker_diagnosis_ns	34913223	hsa-mir-516b	Leukemia, Myeloid, Acute	Peripheral blood samples were obtained from healthy volunteers and AML patients for the measurement of circ_0040823 and miR-516b levels.
lncRNA target	34913063	hsa-mir-145	Triple Negative Breast Neoplasms	CircRNA_0044556 diminished the sensitivity of TNBC cells to ADM via the miR145/NRAS axis.
genetics_knock down_suppress	34912856	hsa-mir-188	Angelman Syndrome	Conclusion: Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS.
genetics_knock down_suppress	34912856	hsa-mir-188	Carotid Artery Diseases	Conclusion: Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS.
circRNA target	34912844	hsa-mir-1281	Glioblastoma	Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed miR-1281 as a potential downstream target of circLRRC7. In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment.
lncRNA target	34912799	hsa-mir-520h	Endometrial Neoplasms	Conclusion: Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer.
lncRNA target	34912799	hsa-mir-520	Endometrial Neoplasms	Conclusion: Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer.
lncRNA target	34912458	hsa-mir-429	Squamous Cell Carcinoma of Head and Neck	Moreover, LINC01303 promoted OSCC through miR-429/ZEB1 axis both in vivo and in vitro.
lncRNA target	34912331	hsa-mir-337	Tuberculosis	Thus, TB-driven single MIR337-3p species could specifically target/impair both TLR4/MYD88 and STAT3 activation signals, inhibiting VitD-dependent antimicrobial response and fast-acting anti-TB immunity, leading to enhanced pathogenicity.
circulation_biomarker_diagnosis_ns	34912238	hsa-mir-1	Myocardial Infarction	The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise.
circulation_biomarker_diagnosis_ns	34912238	hsa-mir-146a	Myocardial Infarction	The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise.
other	34912235	hsa-mir-18a	Cardiomyopathies	NG-HTN demonstrated increased sympatho-excitation with concomitant reduction in UPR(mt), miRNA-18a-5p and increased level of HIF-1alpha in the heart.
other	34912235	hsa-mir-18a	Hypertension	NG-HTN demonstrated increased sympatho-excitation with concomitant reduction in UPR(mt), miRNA-18a-5p and increased level of HIF-1alpha in the heart.
other	34912073	hsa-mir-371a	Adenocarcinoma of Lung	If this can be confirmed in larger cohorts, monitoring miR-371a-3p could replace surveillance imaging in seminomatous GCT and reduce the amount of imaging in non-seminomatous GCT.
other	34912073	hsa-mir-371a	Germ Cell Tumor, Non-Teratomatous	If this can be confirmed in larger cohorts, monitoring miR-371a-3p could replace surveillance imaging in seminomatous GCT and reduce the amount of imaging in non-seminomatous GCT.
lncRNA target	34911869	hsa-mir-147a	Diabetic Nephropathies	Altogether, KCNQ1OT1 mediated the proliferation, ECM accumulation, inflammation, and oxidative stress in HG-treated HGMC cells via miR-147a/SOX6 axis, which might be a novel target for DN therapy.
transcription factor target	34911834	hsa-mir-21	Thyroid Neoplasms	5p in thyroid cancer cells can target the expression of SOSTDC1 and affect the activities of PI3K/Akt and MAPK/ERK, thereby inhibiting the apoptosis of thyroid cancer cells and promoting cell proliferation and migration.
lncRNA target	34911832	hsa-mir-20	Inflammation	The results indicated that miR3p inhibition suppressed H(2)O(2)- induced inflammation, apoptosis, and oxidative stress and promoted the osteogenic differentiation of MC3T3- E1 cells by regulating RUNX2, ALP, and OCN, and this effect was further strengthened by E2.
other	34911544	hsa-mir-129	Pancreatic Carcinoma	CONCLUSIONS: Altogether, the exploration of FOXA1/MIR99AHG/miR5p/ELAVL1/NOTCH2 axis in the progression of PCa might provide a meaningful revelation for PCa diagnosis and treatment.
genetics_GWAS	34911543	hsa-mir-196a-2	Uterine Cervical Neoplasms	The miRNA-196a2 rs11614913 mutation was significantly associated with a reduced risk of cervical cancer in homozygous model (OR = 0.641, 95% CI = 0.447-0.919, P = 0.016; TT vs. CONCLUSION: In summary, this meta-analysis shows that the mutant genotypes of miRNA-146a rs2910164 and miRNA-196a2 rs11614913 are associated with a reduced risk of cervical cancer.
other	34911533	hsa-mir-141	Stomach Neoplasms	based therapy.
genetics_overexpression_promote	34911016	hsa-mir-140	Squamous Cell Carcinoma of Head and Neck	5p overexpression suppressed LSCC cell proliferation and migration.
circulation_biomarker_diagnosis_ns	34910910	hsa-mir-150	Dengue	Here, we identify a human-blood-derived microRNA, hsa-miR5p, that interferes with a mosquito antiviral system to facilitate flavivirus infection and transmission.
other	34910765	hsa-mir-155	Inflammation	11-fold upregulation of MiR5p specifically was found in LS vs.
other	34910765	hsa-mir-155	Lichen Sclerosus et Atrophicus	11-fold upregulation of MiR5p specifically was found in LS vs.
other	34910493	hsa-mir-34a	Breast Neoplasms	In this study, a chitosan-based, self-assembled nanosystem that codelivered microRNA34a (miR34a) and doxorubicin (Dox) with hyaluronic acid (HA) modification (named CCmDH NPs) was developed to reverse the resistance of breast cancer (BCa) cells to Dox. This study provides evidence for the anticancer activity of CCmDH NPs carrying Dox and miR34a in BCa, especially metastatic Dox-resistant BCa models.
other	34910443	hsa-mir-193a	Diabetic Nephropathies	miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways.
other	34910443	hsa-mir-1260b	Diabetic Nephropathies	miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways.
other	34910443	hsa-mir-3175	Diabetic Nephropathies	miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways.
lncRNA target	34910364	hsa-mir-19b	Atherosclerosis	Collectively, this study demonstrates that M-EVs containing miR-19b-3p accelerate migration and promotion of VSMCs through targeting JAZF1, which promotes the development of atherosclerosis.
genetics_GWAS	34908444	hsa-mir-122	Hepatitis C	However, bicistronic HCV replicons and full-length RNAs with specific mutations in the 5' untranslated region (UTR) can replicate, albeit to low levels, without miR-122.
lncRNA target	34907898	hsa-mir-155	Nephritis, Interstitial	Also, CD8(+) T cell exhaustion was also worsened in the absence of miR-155 via targeting of SHIP-1 and SOCS1, showing as up-regulated recruitment of Tregs and expression of PD-1, and down-regulated expression of IFN-gamma and TNF-alpha in CD8(+) T cells.
circulation_biomarker_diagnosis_down	34907223	hsa-mir-197	Encephalomyelitis, Western Equine	Circulating miR
lncRNA target	34907204	hsa-mir-130a	Carcinoma, Hepatocellular	This indicates LINC00667 functions as a tumor promotor in promoting HCC progression through targeting miR-130a-3p/AR axis, making a novel biomarker and potential therapeutic target for HCC.
exosome	34907166	hsa-mir-1246	Colitis	Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium.
exosome	34907166	hsa-mir-1246	Periodontitis	Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium.
other	34907157	hsa-mir-122	Inflammation	As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology.
other	34907157	hsa-mir-122	Fibrosis	As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology.
other	34907157	hsa-mir-122	Carcinoma, Hepatocellular	As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology.
circRNA target	34906917	hsa-mir-942	Colorectal Neoplasms	Collectively, circ_0007919 inhibits CRC cell growth and migration via regulating the miR
lncRNA target	34906656	hsa-mir-142a	Intestinal Diseases	Upregulating the expression of miR-142a-3p inhibited radiation-induced pyroptosis in HIEC, and downregulating the expression of miR-142a-3p led to radiation-induced pyroptosis in HIEC after FlaA N/C pretreatment.
circulation_biomarker_diagnosis_up	34906298	hsa-mir-146a	Neonatal Sepsis	Conclusion The expression of miR-146a-3p is down-regulated and the expression of IL-17 is up-regulated in peripheral blood CD4(+) T cells of children with neonatal sepsis.
target gene	34906151	hsa-mir-606	Pancreatic Neoplasms	CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606.
epigenetics	34906138	hsa-mir-146b	Hematologic Neoplasms	RESULTS: In SCLL, FGFR1 activation silences miR-146b-5p through DNMT1-mediated promoter methylation, which derepresses the downstream target IRAK1.
target gene	34906136	hsa-mir-9	Pancreatic Neoplasms	Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling.
other	34906045	hsa-mir-21	Gliosis	Although miR-21 has been reported as an astrocytic miRNA with an important role in astrogliosis, no link between this miRNA and cellular senescence of astrocytes has been identified.
circulation_biomarker_diagnosis_up	34906021	hsa-mir-24	Brain Neoplasms	Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR.
circulation_biomarker_diagnosis_up	34906021	hsa-mir-9	Brain Neoplasms	Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR.
lncRNA target	34905503	hsa-mir-21	Osteosarcoma	CONCLUSIONS: Circ_0008259 suppresses OS progression via regulating miR
lncRNA target	34905435	hsa-mir-92b	Squamous Cell Carcinoma of Head and Neck	In conclusion, our results suggest that the SP1/miR-92b feedback loop generally promotes HNSCC invasion and metastasis, thus presenting a possible therapeutic target in the treatment of HNSCC patients.
other	34905060	hsa-mir-103a	Glioblastoma	CONCLUSIONS: We suggest that the NF-kappaB-YY1-miR-103a regulatory axis is indispensable for the function of RTP cells in driving radioresistance and recurrence.
circulation_biomarker_diagnosis_up	34904915	hsa-mir-150	Acute Kidney Injury	5p plasma levels in COVID-19 patients may support enhanced SARS-CoV-2 infection.
other	34904852	hsa-mir-155	Hashimoto Disease	The new side of the study was the miRNA-21 and miRNA-155 expressions were in line with other parameters in both the HT and sitagliptin-treated HT groups.
other	34904852	hsa-mir-21	Hashimoto Disease	The new side of the study was the miRNA-21 and miRNA-155 expressions were in line with other parameters in both the HT and sitagliptin-treated HT groups.
transcription factor target	34904343	hsa-mir-548p	Carcinoma, Hepatocellular	ATF2 promoted HCC cell proliferation, migration and invasion and inhibited cell apoptosis through directly targeting miR-548p and controlling its expression.
circRNA target	34904327	hsa-mir-564	Prostatic Neoplasms	CONCLUSIONS: Blocking circDPP4 antagonizes cell progression of PC and contributes to in vitro DTX cytotoxicity via regulating the miR-564/ZIC2 axis, at least.
genetics_overexpression_promote	34904279	hsa-mir-20a	Oculocutaneous Albinism Type 3	It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation.
genetics_overexpression_promote	34904279	hsa-mir-190a	Oculocutaneous Albinism Type 3	It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation.
other	34904279	hsa-mir-93	Oculocutaneous Albinism Type 3	Moreover, we predicted and determined several potential microRNAs (miRs) combining with the 3'-UTR of PAR-1 mRNA, finding that miR-20a-5p, miR5p, and miR-190a-5p were significantly decreased in HG-cultured SH-SY5Y cells compared with control.
genetics_overexpression_promote	34904279	hsa-mir-19a	Oculocutaneous Albinism Type 3	It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation.
circulation_biomarker_diagnosis_up	34904043	hsa-mir-9	Carcinoma, Hepatocellular	RESULTS: The levels of circulating miRNA 9-3p were significantly lower in the HCC group compared to the chronic liver disease (P < 0.001) and control (P < 0.001) groups, while levels in the chronic liver disease were significantly lower than those in the control group (P < 0.001).
genetics_overexpression_promote	34903799	hsa-mir-1179	Carcinoma, Hepatocellular	CircFOXM1 silencing inhibited malignant phenotypes in HCC cells were partly rescued by either miR-1179 silencing or SPAG5 overexpression.
genetics_overexpression_suppress	34903711	hsa-mir-411	Carcinoma, Hepatocellular	KPNA2 silencing, miR5p overexpression, and AKT inhibitor (MK2206) consistently reversed KDM4A-AS1-enhanced proliferation, mobility, and EMT of HCC cells.
other	34903157	hsa-mir-9	Seizures	Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity.
other	34903157	hsa-mir-29a	Seizures	Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity.
genetics_overexpression_promote	34903128	hsa-mir-200a	Osteosarcoma	Overexpression of miR-200a inhibits osteosarcoma cell proliferation, promotes apoptosis, and increases cellular radiosensitivity.
lncRNA target	34903127	hsa-mir-513a	Cholangiocarcinoma	Furthermore, we showed that miR-513a-5p is a regulator of CCA by targeting SFN.
lncRNA target	34903122	hsa-mir-23b	Osteosarcoma	Thus, miR-23b-3p augmented the viability, proliferation, and migration of OS cells by directly targeting and downregulating VEPH1, which inhibited the activation of the PI3K/AKT signaling pathway.
genetics_knock down_promote	34901459	hsa-mir-335	Osteosarcoma	MYH9 overexpression overturned miR
target gene	34901392	hsa-mir-885	Stomach Neoplasms	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway.
lncRNA target	34901284	hsa-mir-218	Squamous Cell Carcinoma of Head and Neck	Additionally, we found that hsa_circ_0023305-mediated upregulation of TRPM7 inhibited miR
other	34901272	hsa-mir-153	Cerebral Infarction, Acute	CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.
other	34901272	hsa-mir-137	Cerebral Infarction, Acute	CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.
other	34901272	hsa-mir-210	Cerebral Infarction, Acute	CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.
circulation_biomarker_diagnosis_ns	34901270	hsa-mir-21	Depression	RESULTS: MiR-21 and FGF1 with increased expression could protect the cardiac function of model rats and improve their diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), coronary flow (CF), bax, and bcl-2 levels, but it would also cause further increase of vascular endothelial growth factor (VEGF) and decreased infarct size (INF).
genetics_overexpression_promote	34901263	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	TNFAIP8 was a functional gene of miR-34a-5p, and the suppressive effects of miR-34a-5p overexpression on DDP-resistant NSCLC progression were dependent on the suppression of TNFAIP8.
target gene	34900997	hsa-mir-206	Histiocytoma, Malignant Fibrous	High Expression MicroRNA-206 Inhibits the Growth of Tumor Cells in Human Malignant Fibrous Histiocytoma.
genetics_overexpression_promote	34900992	hsa-mir-3150a	Prostatic Neoplasms	Importantly, miR-3150a-3p overexpression was related to the increased proliferation and decreased apoptosis of PCa cells.
other	34900814	hsa-mir-135a	Diabetes Mellitus, Type 2	miR-135a expression was considerably higher by 4.7-fold in T(2)D compared to the control group (1.8-fold) (p < 0.001) while the miR126 expression was significantly decreased by 3.9-fold in T(2)D compared to the controls (6.3-fold) (p < 0.001).
other	34900814	hsa-mir-126	Diabetes Mellitus, Type 2	CONCLUSIONS: The results of this case and control study showed that miR-135a and miR126 expression in saliva fluid as a reliable biomarkers and non-invasive approach in combination by change of lipid profiles, glucose and HbA1c may be used to monitor diabetic and non-diabetic patients, while further research is needed to investigate the relationship of these salivary miRNAs (miR135a, miR126) levels change on shifting the levels of clinical laboratory outcomes.
other	34900811	hsa-mir-145	Diabetes Mellitus	This study intended to study the effects of eight weeks of moderate and high intensity aerobic training (MIT&HIT) on the mRNA of Mir-145, Wnt3a, and Dab2 in heart tissue of type 2 diabetic rats. RESULTS: Moderate and high intensity aerobic training was associated with non-significant increase in Mir-145 mRNA of Heart tissue in type 2 diabetic rats than the diabetic control group(P < 0.05).
lncRNA target	34900737	hsa-mir-155	Carcinoma, Non-Small-Cell Lung	Finally, high levels of miR-155 in the cachectic group lead to negative feedback inhibition of both SOCS1 and Foxp3 in both the pancreatic and NSCL cancer patients.
transcription factor target	34900727	hsa-mir-216a	Adenocarcinoma of Lung	Interfering with miR-216a-5p expression and activating the JAK2/STAT3 signaling pathway can significantly reverse LNT inhibitory effects on LUAD. Collectively, LNT can inhibit the JAK2/STAT3 signaling pathway by up-regulating miR-216a-5p, reducing stemness, and promoting LUAD cells apoptosis, then slow down LUAD occurrence and development, providing concepts and experimental foundation treating patients with LUAD.
circulation_biomarker_diagnosis_up	34900665	hsa-mir-1204	Carcinoma, Hepatocellular	Additionally, circ_0000098 was mainly distributed in the cytoplasm of HCC cells, and up-regulated ALX4 expression through competitively decoying miR-1204. CONCLUSION: Circ_0000098, as a competitive endogenous RNA (ceRNA) of miR-1204, upregulates ALX4 expression and suppresses the growth, migration, invasion, and EMT of HCC cells.
circulation_biomarker_diagnosis_up	34900532	hsa-mir-21	Brain Injuries, Traumatic	Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI.
genetics_overexpression_promote	34900520	hsa-mir-21	Anodontia	After overexpressing miR
transcription factor target	34900201	hsa-mir-20	Acute Lung Injury	CONCLUSIONS: miR-204 participates in the protection of HA acute lung injury by targeting FOXK2.
transcription factor target	34900201	hsa-mir-204	Acute Lung Injury	CONCLUSIONS: miR-204 participates in the protection of HA acute lung injury by targeting FOXK2.
other	34900149	hsa-mir-222	Hepatitis B, Chronic	Further studies should be conducted to confirm whether miR-222 can be a biomarker for prognosis of severe liver diseases.
genetics_knock down_suppress	34900056	hsa-mir-186	Stomach Neoplasms	In particular, OIP5-AS1 may function as a ceRNA for miR-186, and inhibition of miR-186 blocks the effects of OIP5-AS1 knockdown on aerobic glycolysis in GC cells.
circulation_biomarker_diagnosis_ns	34900055	hsa-mir-16	polycystic kidney disease 3	MiR5p was selected as the best circulating biomarker of ADPKD.
target gene	34899909	hsa-mir-296	Carcinoma, Hepatocellular	In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion.
circRNA target	34899908	hsa-mir-139	Pancreatic Carcinoma	CONCLUSION: CircRNF13 serves as a competitive endogenous RNA of IGF1R to inhibit the function of miR
genetics_overexpression_promote	34899906	hsa-mir-145	Prostatic Neoplasms	5p overexpression on PCa were studied using cell proliferation, migration, and invasion experiments.
circulation_biomarker_diagnosis_ns	34899857	hsa-mir-92a	Lymphoma, Non-Hodgkin	92 cluster host gene and the TET2 gene and correlated them with the expression levels of TET2 mRNA and miR-92a-3p and miR-92a-5p mature miRNAs in NHL cell lines, tumour samples, and the whole blood gDNA of an NHL case control cohort.
genetics_overexpression_suppress	34899853	hsa-mir-1205	Stomach Neoplasms	MiR-1205 overexpression restrained the resistance of DDP-resistant GC cells to DDP, but FGFR1 elevation abated the effect.
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-1233	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-4532	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-5100	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-184	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-4787	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-20b	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-6800	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-1228	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-1290	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
circulation_biomarker_diagnosis_ns	34899827	hsa-mir-4783	Ovarian Neoplasms	By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR
transcription factor target	34899681	hsa-mir-221	Acute Lung Injury	5p targets JNK2 and thereby aggravates lung inflammation and injury during sepsis.
circulation_biomarker_diagnosis_up	34899574	hsa-mir-210	Carotid Stenosis	Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR
circulation_biomarker_diagnosis_up	34899574	hsa-mir-92a	Carotid Stenosis	Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR
circulation_biomarker_diagnosis_up	34899574	hsa-mir-145	Carotid Stenosis	Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR
circulation_biomarker_diagnosis_up	34899574	hsa-mir-143	Carotid Stenosis	Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR
other	34899562	hsa-mir-29a	Parkinson Disease	Conclusion: The miRNA combination of salivary miR-29a-3p and miR-29c-3p has potential to be a diagnostic biomarker for idiopathic PD.
other	34899562	hsa-mir-29c	Parkinson Disease	Conclusion: The miRNA combination of salivary miR-29a-3p and miR-29c-3p has potential to be a diagnostic biomarker for idiopathic PD.
circulation_biomarker_diagnosis_ns	34899022	hsa-mir-129	Fatty Liver	5p, in goose fatty liver was also significantly higher than that in normal liver (P<0.05), suggesting that these blood miRNAs are released from goose fatty liver.
lncRNA target	34898474	hsa-mir-432	Cholangiocarcinoma	The promoting effect of circ-ZNF609 on cholangiocarcinoma is achieved via oncogene LRRC1 up-regulation through targeting miR
lncRNA target	34898380	hsa-let-7d	Lung Neoplasms	Huaier/let-7d-5p/NAP1L1 axis is supposed to be a promising target for the treatment of angiogenesis and tumor growth in LC via elevated let-7d-5p and targeted NAP1L1.
other	34898376	hsa-mir-4435-2	Squamous Cell Carcinoma of Head and Neck	WGCNA and Kaplan-Meier survival analysis revealed that 5 DELs (MIR4435-2 HG, CASC9, LINC01980, STARD4-AS1 and MIR99AHG) were significantly correlated with OS of HNSCC patients, whereas DEL PART1 was most significantly correlated with the HNSCC tumor. The in silico predicted expression patterns of PART1, LINC01980 and MIR4435-2 HG were further validated in HNSCC cell lines and patient sera.
exosome	34898374	hsa-mir-93	Wounds and Injuries	Collectively, the results indicate that BMSC-derived exosomes promote skin wound healing via the miR3p/APAF1 axis.
circulation_biomarker_diagnosis_ns	34898373	hsa-mir-590	Diabetic Nephropathies	Serum miR
lncRNA target	34898365	hsa-mir-369	Osteoarthritis	3p/JAK2/STAT3 signaling pathway to accelerate the viability, and inhibit inflammation and cell apoptosis in OA chondrocytes.
other	34898362	hsa-mir-378b	Fatty Liver	This study aims to clarify the biological function of microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid accumulation.
lncRNA target	34898360	hsa-mir-146	Kidney Diseases	It can be seen that the expression of miR-146 inhibits inflammatory factors, apoptosis, oxidative stress and NF- kappa the activation of B pathway promotes the repair of renal injury in CPB rats.
circulation_biomarker_diagnosis_ns	34898354	hsa-mir-127	Aortic Aneurysm, Abdominal	5p/NCK-associated protein 1-like axis The long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) has been implicated in the progression of abdominal aortic aneurysms (AAA).
genetics_overexpression_suppress	34898351	hsa-mir-582	Stomach Neoplasms	3p inhibition or DIXDC1 overexpression could reverse the above-mentioned effects of knocking down circ_0000423 on GC cells.
lncRNA target	34898169	hsa-mir-27a	Breast Neoplasms	We selected oncogenic microRNA-27a (miR-27a) for further study as a lead molecule binds its Drosha site and a nearby internal loop, affording a homodimer that potently and specifically inhibits miR-27a processing in both breast cancer and prostate cancer cells.
other	34897970	hsa-mir-141	Cardiotoxicity	However, the role of miR3p in myocardial lipotoxicity remains elusive.
transcription factor target	34897970	hsa-mir-141	Cardiomyopathies	In conclusion, the present study demonstrates that miR3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1, which gains a new insight into the mechanisms of myocardial lipotoxic injury.
transcription factor target	34897970	hsa-mir-141	Hyperlipidemias	3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1, which gains a new insight into the mechanisms of myocardial lipotoxic injury.
other	34897970	hsa-mir-141	Obesity	It has been reported that miR3p levels are markedly upregulated in the cardiomyocytes of obese rats induced by a high-fat diet.
exosome	34897628	hsa-mir-124	Brain Injuries	3p expression is enhanced in microglia-derived exosomes following TBI, with this miRNA being capable of promoting neural repair after such injury.
genetics_overexpression_promote	34897468	hsa-mir-204	Thyroid Cancer, Papillary	Several microRNAs (miRs) targeting nodes in the transforming growth factor beta (TGFbeta)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group.
genetics_overexpression_promote	34897468	hsa-mir-205	Thyroid Cancer, Papillary	Several microRNAs (miRs) targeting nodes in the transforming growth factor beta (TGFbeta)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group.
circulation_biomarker_diagnosis_up	34897278	hsa-mir-184	Myocardial Infarction	Thus, miR-184 is a circulating biomarker of AFD that changes after ERT.
circulation_biomarker_diagnosis_up	34897278	hsa-mir-184	Fabry Disease	Thus, miR-184 is a circulating biomarker of AFD that changes after ERT.
transcription factor target	34897031	hsa-mir-338	Glioma	We acquired miR5p, which suppresses the development of glioma, from the GEO and CGGA databases.
other	34896914	hsa-mir-105	Prostatic Neoplasms	CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR5p, resulted in upregulation of the expression of PD-L1.
genetics_overexpression_promote	34896865	hsa-mir-494	Squamous Cell Carcinoma of Head and Neck	In addition, NR2F2-AS1 silencing increased OSCC cell proliferation rate while overexpression of miR-494 and NR2F2-AS1 decreased OSCC cell proliferation.
lncRNA target	34896788	hsa-mir-216b	Carcinoma, Non-Small-Cell Lung	TargetScan analysis manifested that miR-216b, targeted by MALAT1, was down-regulated in NSCLC cells.
circulation_biomarker_diagnosis_up	34895840	hsa-mir-144	Alzheimer Disease	Circulating miR
genetics_overexpression_promote	34895074	hsa-mir-128	Glioblastoma	3p as a tumor-suppressor whose overexpression restored the sensitivity of TMZ in GBM cells.
lncRNA target	34895065	hsa-mir-5195	Carcinoma, Hepatocellular	3p and transcription factor forkhead box O1 (FOXO1) to identify a novel target for HCC treatment.
circulation_biomarker_diagnosis_up	34895055	hsa-mir-1255b	Prostatic Neoplasms	The measurement of miR-1255b-5p in blood may provide a new noninvasive approach for the diagnosis of prostate cancer.
lncRNA target	34895052	hsa-mir-27b	Neurogenic Inflammation	These data revealed that miR-27b-3p could mediate not only microglia activation but also neuroinflammation via downregulating A20 expression.
other	34895052	hsa-mir-27b	Spinal Cord Injuries	Thus, miR-27b-3p is regarded as gene therapy in treating cerebral hemorrhage and spinal cord injury.
other	34895052	hsa-mir-27b	Cerebral Hemorrhage	Thus, miR-27b-3p is regarded as gene therapy in treating cerebral hemorrhage and spinal cord injury.
lncRNA target	34895051	hsa-mir-378	Osteoporosis-pseudoglioma syndrome	HOTAIR negatively regulates miR-378g by targeting NNMT.HOTAIR is an miR-378g sponge that targets NNMT, inhibits the osteogenic differentiation of BMSCs, and provides a valuable target for the treatment of OP.
genetics_overexpression_promote	34895048	hsa-mir-98	Uterine Cervical Neoplasms	Overexpression miR
transcription factor target	34895047	hsa-mir-187	Cardiovascular Diseases	It is suggested that miR3p may be an important target for CTS participate in the process of cardiovascular disease.[Figure: see text].
genetics_overexpression_suppress	34895046	hsa-mir-144	Breast Neoplasms	Overexpression of miR-144 can reduce drug resistance in breast cancer cells by inhibiting autophagy or targeting DNAJC3-AS1 for downregulation.
lncRNA target	34895044	hsa-mir-20b	Inflammatory Bowel Diseases	Collectively, our findings revealed that M2-EVs carrying MEG3 enhanced UC cell viability and reduced inflammatory responses via the miR-20b-5p/CREB1 axis, thus alleviating UC inflammation.
genetics_overexpression_promote	34895042	hsa-mir-19a	Leukemia, Myeloid, Acute	Overexpression of miR-19a-3p had the opposite effect in AML cells, suggesting simvastatin-inhibited AML by reducing miR-19a-3p expression.
circulation_biomarker_diagnosis_up	34895039	hsa-mir-496	Endometrial Neoplasms	phenylindole; DMEM: Dulbecco's minimal essential medium/Ham's; ECL: enhanced chemiluminiscent; ELISA: Enzyme-Linked Immunosorbent Assay; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; FISH:Fluorescence in situ hybridization; FITC:fluorescein isothiocyanate; FSP:fibroblast-specific protein; GAPDH: glyceraldehyde
circRNA target	34894939	hsa-mir-1248	Pre-Eclampsia	CONCLUSION: GNB5 and IL2RB might be key genes involved in the PI3K-Akt signalling pathway in PE, and hsa_circ_0087208, hsa_circ_0035443, hsa_circ_0067557 and hsa_circ_0052661 might regulate these key genes in PE by binding miR-1248 or miR-4303.Key messagesThere is still a lack of predictive and diagnostic factors for preeclampsia, which is a common cause of maternal death worldwide.This study identified a novel circRNA-associated ceRNA network and related pathways in preeclampsia.GNB5 and IL2RB might be key genes in their related circRNA-associated ceRNA network, and probably take an important role in preeclampsia via PI3K-Akt signalling pathway, which made them to be potential markers of preeclampsia.
circRNA target	34894939	hsa-mir-4303	Pre-Eclampsia	CONCLUSION: GNB5 and IL2RB might be key genes involved in the PI3K-Akt signalling pathway in PE, and hsa_circ_0087208, hsa_circ_0035443, hsa_circ_0067557 and hsa_circ_0052661 might regulate these key genes in PE by binding miR-1248 or miR-4303.Key messagesThere is still a lack of predictive and diagnostic factors for preeclampsia, which is a common cause of maternal death worldwide.This study identified a novel circRNA-associated ceRNA network and related pathways in preeclampsia.GNB5 and IL2RB might be key genes in their related circRNA-associated ceRNA network, and probably take an important role in preeclampsia via PI3K-Akt signalling pathway, which made them to be potential markers of preeclampsia.
other	34894715	hsa-mir-1	Colorectal Neoplasms	Aims: To study the association between miR-31 expression and clinical outcomes in colorectal cancer.
other	34894598	hsa-mir-21	Breast Neoplasms	A dual-mode electrochemical biosensor is successfully developed for simultaneous detection of two different kinds of breast cancer biomarkers, namely cancer antigen 15-3 (CA 15-3) and microRNA-21 (miRNA-21), for the first time.
circulation_biomarker_prognosis_ns	34894384	hsa-mir-503	Squamous Cell Carcinoma of Head and Neck	3p-BAK axis may be a therapeutic target and that circulating miR
other	34893896	hsa-mir-160	Dehydration	Our study revealed the mechanisms by which the positive feedback loop of Mdm-miR160-MdARF17-MdHYL1 influences apple drought tolerance.
genetics_overexpression_promote	34893101	hsa-mir-146a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Plasma miR-146a is overexpressed and miR-223 is low-expressed in children with ALL, the abnormal expression of the two factors is related to the prognosis of children with ALL.
genetics_overexpression_promote	34893101	hsa-mir-223	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Plasma miR-146a is overexpressed and miR-223 is low-expressed in children with ALL, the abnormal expression of the two factors is related to the prognosis of children with ALL.
other	34893096	hsa-mir-143	Leukemia	CONCLUSION: Expression of miR-143 in AML patients is lower than that in normal controls.
other	34893064	hsa-mir-224	Esophageal Squamous Cell Carcinoma	3p.
genetics_knock down_promote	34892984	hsa-mir-27a	Obesity	CONCLUSION: We found that EA could regulate miRNA27a-mediated autophagy-related proteins and promote white fat browning, which may contribute to weight loss.
circulation_biomarker_diagnosis_ns	34891212	hsa-mir-26a	Diabetic Nephropathies	Besides, serum miR-26a-5p was diminished in DN patients, and luciferase reporter gene revealed that miR-26a-5p is direct target of SNHG5. These results indicated that inhibition of SNHG5 may mitigate HG-induced renal tubular damage via targeting miR-26a-5p, which providing a new insight into the mechanism of renal tubule damage in DN patients.
genetics_overexpression_suppress	34891100	hsa-mir-149	Squamous Cell Carcinoma of Head and Neck	3p-mediated decrease in metastasis was reversed by overexpression of MMP2 in OSCC cells.
genetics_overexpression_promote	34891002	hsa-mir-7	Osteoarthritis	In our previous findings, we demonstrated that overexpression of miR-7 was found in OA and promoted OA development.
circulation_biomarker_diagnosis_ns	34890883	hsa-mir-125b	Alzheimer Disease	Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples.
circulation_biomarker_diagnosis_ns	34890883	hsa-mir-15a	Alzheimer Disease	Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples.
circulation_biomarker_diagnosis_ns	34890883	hsa-mir-361	Alzheimer Disease	Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples.
transcription factor target	34890627	hsa-mir-181a	Papilloma, Choroid Plexus	To identify targets for chemoprevention, we previously reported a cross-species analysis to identify the transcriptional drivers of cSCC development and identified miR-181a as a potential oncomiR.
circulation_biomarker_diagnosis_up	34889994	hsa-let-7a	Ovarian Neoplasms	In urine, miR-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients. Especially, miR-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients.
circulation_biomarker_diagnosis_up	34889994	hsa-mir-15a	Ovarian Neoplasms	In urine, miR-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients. Especially, miR-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients.
genetics_GWAS	34889890	hsa-mir-128a	Diabetes Mellitus, Type 2	In this study we investigated the associations of the VEGF-2578 C/A (rs699947), VEGF-2549 insertion/deletion (I/D), and ACE I/D rs4646994 and Mir128a (rs11888095) gene variations with T2D using the amplification refractory mutation system PCR (ARMS-PCR) and mutation specific PCR (MSP).
lncRNA target	34889712	hsa-mir-665	Neuroblastoma	Together, our data demonstrated that lncRNA NHEG1 serves as a competitive partner to negatively regulate the activity of miR-665, which relieves the inhibition on HMGB1 expression and promotes the aggressive phenotype of neuroblastoma cells. Our study indicates that lncRNA NHEG1/miR-665/HMGB1 axis may play an important role in regulating the aggressiveness and the progression of neuroblastoma.
other	34889689	hsa-mir-338	Urinary Bladder Neoplasms	3p/ETS1/PI3K/AKT pathway is involved in regulating BC progression.
lncRNA target	34889164	hsa-mir-21	Breast Neoplasms	These results suggest that lncRNA CASC7 suppresses to malignant behaviors of breast cancer by modulating miR5p/FASLG axis.
genetics_overexpression_promote	34888946	hsa-mir-100	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: HAGLROS overexpression contributes to DLBCL development and poor prognosis via targeting miR-100, which could be a potential prognostic biomarker and therapeutic target for DLBCL patients.
genetics_knock down_promote	34888746	hsa-mir-103	spondyloepimetaphyseal dysplasia, Strudwick type	Knockdown of miRNA-103 displayed similar effects as knockdown of HIF-1alpha in ASM cells under hypoxia, while overexpression of miRNA-103 played the opposite role.
genetics_knock down_promote	34888652	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	Furthermore, overexpression of miR-145 could sensitize radioresistant NSCLC cells to IR, whereas knockdown of miR-145 in NSCLC cells acted the converse manner.
other	34888382	hsa-mir-23a	Periodontitis	CONCLUSION: Saliva miR-23a and miR-146a can be used as biomarkers for the diagnosis and assessment of periodontitis, and they may have regulatory relationships with IL-1beta, IL-6, and IL-17.
other	34888382	hsa-mir-146a	Periodontitis	CONCLUSION: Saliva miR-23a and miR-146a can be used as biomarkers for the diagnosis and assessment of periodontitis, and they may have regulatory relationships with IL-1beta, IL-6, and IL-17.
genetics_GWAS	34888351	hsa-mir-15a	Liver Injury	In summary, our results identified hsa-miR-15a-3p as a novel epigenetic factor modulating NAT2 expression and as a protective module against INH-induced liver injury, and provided new clues to elucidate the epigenetic regulatory mechanisms concerning drug-induced liver injury (DILI).
target gene	34888223	hsa-mir-146a	Colorectal Neoplasms	miR-146a-5p and miR-193a-5p Synergistically Inhibited the Proliferation of Human Colorectal Cancer Cells (HT-29 cell line) through ERK Signaling Pathway.
other	34888219	hsa-mir-221	Myocardial Infarction	3p as informative biomarkers and positively correlated with artery stenosis in MI.
other	34888219	hsa-mir-1	Myocardial Infarction	3p as informative biomarkers and positively correlated with artery stenosis in MI.
genetics_overexpression_promote	34888137	hsa-mir-33a	Carcinoma, Non-Small-Cell Lung	miRNA-33a-5p overexpressed in LUSC was supported by 706 LUSC and 261 non-LUSC samples gathering from RT-qPCR, miRNA-seq, and public miRNA microarrays.
transcription factor target	34887931	hsa-mir-24	Non-alcoholic Fatty Liver Disease	It likely acts by altering miRNA-24 expression and regulating the target TRPM4 protein pathway to achieve NAFLD treatment.
circRNA target	34887753	hsa-mir-1291	Liver Cirrhosis	In conclusion, our current results reveal a novel mechanism by which circCREBBP alleviates liver fibrosis by targeting the hsa-miR-1291/LEFTY2 axis, and also suggest that circCREBBP may be a potential biomarker for heart failure.
other	34887672	hsa-mir-197	Non-alcoholic Fatty Liver Disease	The HCG18-miR3p axis exerted effects on the progression of fat sedimentation and glucose disorder in NAFLD.
other	34887647	hsa-mir-26a	Pancreatitis	5p and miR-762.
other	34887647	hsa-mir-92b	Pancreatitis	5p and miR-762.
other	34887647	hsa-mir-24	Pancreatitis	5p and miR-762.
other	34887647	hsa-mir-762	Pancreatitis	5p and miR-762.
other	34887647	hsa-mir-216b	Pancreatitis	5p and miR-762.
circulation_biomarker_diagnosis_ns	34887646	hsa-mir-192	Acute Lung Injury	We established serum sEV miRNA signatures for ALI and CLI and a panel of miRNAs (miR
circulation_biomarker_diagnosis_ns	34887646	hsa-mir-122	Acute Lung Injury	We established serum sEV miRNA signatures for ALI and CLI and a panel of miRNAs (miR
genetics_GWAS	34887601	hsa-mir-370	Depressive Disorder	The objective of the study was to evaluate the impact of 1846G>A polymorphism of the CYP2D6 gene on the concentration/dose indicator of phenazepam, using findings on enzymatic activity of CYP2D6 (as evaluated by the 6M-THBC/pinoline ratio measurement) and on CYP2D6 expression level obtained by measuring the hsa-miR3p plasma concentration levels in patients suffering from major depressive disorder.
other	34887515	hsa-mir-1246	Cardiovascular Diseases	Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9).
other	34887515	hsa-mir-1246	Alzheimer Disease	Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9).
circulation_biomarker_diagnosis_up	34887498	hsa-mir-455	Liver Neoplasms	Increased serum levels of miR
circulation_biomarker_diagnosis_up	34887498	hsa-mir-122	Liver Neoplasms	Increased serum levels of miR
circulation_biomarker_diagnosis_up	34887498	hsa-mir-122	Diabetes Mellitus, Type 2	Increased serum levels of miR
circulation_biomarker_diagnosis_up	34887498	hsa-mir-455	Diabetes Mellitus, Type 2	Increased serum levels of miR
lncRNA target	34887384	hsa-mir-188	Ovarian Neoplasms, High-Grade Serous	Collectively, these results reveal a novel ETV5/lncRNA CTBP1-DT/miR5p/MAP3K3 pathway for HGSOC progression and suggest that lncRNA CTBP1-DT might be a potential biomarker and therapeutic target for HGSOC.
lncRNA target	34887365	hsa-mir-29a	Cardiomyopathies	The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-beta axis.
lncRNA target	34887365	hsa-mir-29b	Cardiomyopathies	The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-beta axis.
circulation_biomarker_diagnosis_up	34887365	hsa-mir-29a	Atrial Fibrillation	Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (r(s) = -0.337, r(s) = -0.236).
circulation_biomarker_diagnosis_up	34887365	hsa-mir-29b	Atrial Fibrillation	Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (r(s) = -0.337, r(s) = -0.236).
lncRNA target	34887360	hsa-mir-21	Atherosclerosis	CASC7 inhibited proliferation and enhanced the apoptosis of VSMC through modulating the miR-21/PI3K-AKT axis, and upregulating CASC7 suppressed the inflammatory response of HUVEC by sponging miR-21 to inhibit the TLR4/NF-kappaB signal pathway.
lncRNA target	34887123	hsa-mir-214	Keloid	In summary, lnc-H19 may exert regulatory functions in KD by targeting miR
lncRNA target	34887123	hsa-mir-214	Mucocutaneous Lymph Node Syndrome	In summary, lnc-H19 may exert regulatory functions in KD by targeting miR
circulation_biomarker_diagnosis_ns	34886843	hsa-let-7b	Depressive Disorder, Major	CONCLUSIONS: These findings show that lower plasma levels of let-7b-5p are associated with a higher future risk of MDD.
other	34885115	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	The MEK/ERK/miR-21 Signaling Is Critical in Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells.
target gene	34885090	hsa-mir-195	Breast Neoplasms	MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer.
epigenetics	34885060	hsa-mir-129-2	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-137	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-34b	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-548i	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-19a	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-548f	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-548g	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-124	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-124-2	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-9	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-1204	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-17	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-18a	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-34c	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-20a	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-19b	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
epigenetics	34885060	hsa-mir-762	Colorectal Neoplasms	We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis.
genetics_knock down_promote	34884984	hsa-mir-214	Prostatic Neoplasms	Knockdown of miR-214 increased the expression of its target protein, Protein Tyrosine Kinase 6 (PTK6), a kinase shown to promote oncogenic signaling and tumorigenesis in PCa.
transcription factor target	34884968	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway.
transcription factor target	34884968	hsa-mir-34a	Inflammation	Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway.
circulation_biomarker_diagnosis_ns	34884950	hsa-mir-15a	Multiple Myeloma	3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without.
circulation_biomarker_diagnosis_ns	34884950	hsa-mir-222	Multiple Myeloma	3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without.
circulation_biomarker_diagnosis_ns	34884950	hsa-mir-16	Multiple Myeloma	3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without.
circulation_biomarker_diagnosis_ns	34884950	hsa-mir-155	Multiple Myeloma	5p expression was significantly lower in the CD138+ plasma cells of MM patients than in those of sMM patients.
other	34884950	hsa-mir-223	Multiple Myeloma	Furthermore, lower levels of miR3p were associated with significantly worse overall survival in MM patients.
lncRNA target	34884879	hsa-mir-143	Fibrosis	MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting hepatoma cell proliferation.
epigenetics	34884879	hsa-mir-143	Carcinoma, Hepatocellular	In summary, we are the first to report the change in whole-genome methylation levels by miR
genetics_knock down_suppress	34884879	hsa-mir-143	Liver Diseases	We found that methylated cytosines increased 0.19% in the miR-143 knock-out (KO) liver fed with high-fat diet (HFD), compared with the wild type (WT).
lncRNA target	34884671	hsa-mir-122	Lung Neoplasms	5p was selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1.
other	34884541	hsa-mir-3927	Osteosarcoma	Analysis of osteosarcoma cell lines identified that CCL4 promotes integrin alphavbeta3 expression and cell migration by activating the focal adhesion kinase (FAK), protein kinase B (AKT), and hypoxia inducible factor 1 subunit alpha (HIF-1alpha) signaling pathways, which can downregulate microRNA3p expression.
transcription factor target	34884487	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR5p were significantly downregulated in OSCC tissues.
transcription factor target	34884487	hsa-mir-140	Squamous Cell Carcinoma of Head and Neck	TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR5p were significantly downregulated in OSCC tissues.
lncRNA target	34884485	14q32 cluster	Hyperphenylalaninemia with primapterinuria	We hypothesized that CIRBP deficiency improves post-ischemic angiogenesis via downregulation of 14q32 microRNA expression.
genetics_overexpression_promote	34883316	hsa-mir-296	Colorectal Neoplasms	5p and ALO treatment both suppressed STAT3 expression, inhibited CRC cell proliferation, migration, invasion as well as the expressions of Bcl-2 and N-cadherin, but promoted apoptosis and expressions of Bax and E-cadherin, which were all reversed by overexpressed STAT3.
other	34882981	hsa-mir-156	Polythelia, Familial	For this, we used the GA-induced grapevine parthenocarpy system to investigate the regulatory roles of VvmiR156a during this process.
lncRNA target	34882869	hsa-mir-21	Colorectal Neoplasms	Overall, the current study's findings for the first time reveal that LOC100507144 could enhance CRC progression and metastasis through regulation of the CD44/Nanog/Sox2/miR-302/miR-21 axis.
other	34882856	hsa-mir-1271	Breast Neoplasms	Overall, LINC02381 exerts carcinogenic effects in BC by the miR5p/FN1 axis to activate PI3K/AKT pathway.
other	34882650	hsa-mir-181a-1	Wounds and Injuries	After analyzing competitive endogenous RNA network, 4 upregulated (MEG8, MEG3, MIR181A1HG, MIR4435-2HG) lncRNAs were found expressed during wound healing.
other	34882650	hsa-mir-4435-2	Wounds and Injuries	After analyzing competitive endogenous RNA network, 4 upregulated (MEG8, MEG3, MIR181A1HG, MIR4435-2HG) lncRNAs were found expressed during wound healing.
circulation_biomarker_diagnosis_up	34882521	hsa-mir-132	Pancreatitis	3p was downregulated in AP patients' plasma and human pancreatic ductal HPDE6-C7 cells with caerulein induction.
lncRNA target	34882302	hsa-mir-21	Hyperoxia-Induced Lung Injury	5p and SKP2 mRNA, inhibiting the expression of SKP2, reducing the ubiquitination level of Nr2f2, increasing the expression of Nr2f2, promoting the binding of Nr2f2 and the C/EBPalpha promoter, upregulating C/EBPalpha mRNA level, and eventually alleviating HILI.
other	34882294	hsa-mir-27	Obesity	RESULTS: We found no differences in the expression of PPAR-gamma and miR-27 in adipose tissue of obese patients vs.
other	34882294	hsa-mir-27a	Obesity	RESULTS: We found no differences in the expression of PPAR-gamma and miR-27 in adipose tissue of obese patients vs.
lncRNA target	34882114	hsa-mir-379	Angelman Syndrome	Collectively, these results demonstrated that circ_0002984 promoted PDGF-bb-induced VSMC proliferation, migration, and invasion through the regulation of miR5p/FRS2 axis, suggesting a new insight into the pathogenesis of AS and the potential application of circ_0002984 in AS treatment.
genetics_knock down_suppress	34882112	hsa-mir-148b	Angelman Syndrome	In conclusion, circUSP9X knockdown relieved ox-LDL-triggered HUVEC injuries during AS progression partly by mediating the miR-148b-3p/KLF5 network.
other	34882040	hsa-mir-185	Virus Diseases	Compared with normal transplanted patients, miR-29b, miR-185, and NR_073415.2 were significantly downregulated in the PBMC of post-transplant patients with viral infection.
other	34882040	hsa-mir-29b	Virus Diseases	Compared with normal transplanted patients, miR-29b, miR-185, and NR_073415.2 were significantly downregulated in the PBMC of post-transplant patients with viral infection.
lncRNA target	34881629	hsa-mir-203b	Carcinoma, Hepatocellular	The in vivo experiments upheld the LINC00536/miR-203b-5p/VEGFA axis in HCC. Conclusively, LINC00536 could promote HCC deterioration via tuning the miR-203b-5p/VEGFA axis.
genetics_knock down_promote	34881627	hsa-mir-592	Leukemia, Myeloid, Acute	Moreover, miR-592 overexpression reversed the influences of LINC01116 overexpression on matrine-treated AML cells.
transcription factor target	34881229	hsa-mir-491	Prostatic Neoplasms, Castration-Resistant	5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth.
circulation_biomarker_diagnosis_up	34880957	hsa-mir-205	Myocardial Infarction	3p and TGF-beta1 were downregulated in plasma of MI patients in the TSN group.
exosome	34880915	hsa-mir-34a	Melanoma	Metformin Increases Sensitivity of Melanoma Cells to Cisplatin by Blocking Exosomal-Mediated miR-34a Secretion.
other	34880646	hsa-mir-429	Crohn Disease	The constructed MIR3142HG/mir-429/PTGS2 ceRNA network may play a role in CD, and PTGS2 can be a potential immune-related biomarker in CD.
other	34880646	hsa-mir-142	Crohn Disease	The constructed MIR3142HG/mir-429/PTGS2 ceRNA network may play a role in CD, and PTGS2 can be a potential immune-related biomarker in CD.
other	34880629	hsa-mir-21	gastric adenocarcinoma	5p/TLR4 regulatory axis in STAD.
circulation_biomarker_diagnosis_ns	34880446	hsa-mir-200b	Hirschsprung Disease	Three plasma miRNAs (miR-200a-3p, miR
circulation_biomarker_diagnosis_ns	34880446	hsa-mir-200a	Hirschsprung Disease	Three plasma miRNAs (miR-200a-3p, miR
circulation_biomarker_diagnosis_ns	34880446	hsa-mir-192	Hirschsprung Disease	Three plasma miRNAs (miR-200a-3p, miR
genetics_knock down_promote	34880414	hsa-mir-200c	Liver Injury	Phenotypically, loss of miR-200c exacerbated cholestatic liver injury, including periductular fibrosis, intrahepatic inflammation, and biliary hyperplasia in both the BDL model and the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) model.
transcription factor target	34880230	hsa-mir-675	facioscapulohumeral muscular dystrophy 1	upregulating small molecules inhibit DUX4 and DUX4-activated FSHD biomarkers in FSHD patient-derived myotubes.
transcription factor target	34879879	hsa-mir-425	Osteoporosis	5p might serve as a potential therapeutic target for the treatment of osteoporosis.
circulation_biomarker_diagnosis_ns	34879814	hsa-mir-27b	Pre-Eclampsia	CONCLUSION: miR-27b-3p expression in serum of pregnant women with PE was positively correlated with the severity of PE symptoms, suggesting the involvement of miR-27b-3p in PE occurrence.
epigenetics	34879371	hsa-mir-141	Pre-Eclampsia	3p and methylation status of the miR
transcription factor target	34879291	hsa-mir-17	Intervertebral Disc Degeneration	In conclusion, H-sEVs miR5p alleviate IDD via promoting HNPCs matrix proliferation and synthesis, providing new therapeutic targets for IDD.
virus_miRNA	34878852	ebv-mir-BHRF1-3	Epstein-Barr Virus Infections	Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3'UTR and Regulates the Lytic Cycle
genetics_GWAS	34878652	hsa-mir-2118	Infertility, Male	The MIR2118 family has undergone tremendous expansion in the grass lineage, in which the miRNA targets numerous noncoding PHAS loci to produce 21-nt phased small interfering RNAs (phasiRNAs) involved in male fertility.
lncRNA target	34878161	hsa-mir-133b	Squamous Cell Carcinoma of Head and Neck	In conclusion, the current results indicated that HCG18 facilitated the progression of LHSCC by upregulating FGFR1 via miR133b.
other	34877935	hsa-mir-1262	Arthritis, Rheumatoid	On the other hand, we also demonstrate that LINK-A could bind with microRNA 1262 as a sponge to control RA FLS aggression but not inflammation.
genetics_knock down_suppress	34877817	hsa-mir-138	Cystic Fibrosis	Several in vitro strategies can partially correct DeltaF508-CFTR trafficking and function, including low-temperature, small molecules, overexpression of miR-138, or knockdown of SIN3A.
other	34877353	hsa-mir-146a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone.
other	34877353	hsa-mir-155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone.
other	34877353	hsa-mir-181a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone.
transcription factor target	34876932	hsa-mir-29a	Brain Injuries, Traumatic	miR-29a-5p targets to NLRP3 through the binding on its 3'UTR and negatively regulates its expression in TBI model cells.
transcription factor target	34876915	hsa-mir-4461	Ovarian Neoplasms	CONCLUSION: Alkannin restrains cell viability, metastasis, and EMT in OC by downregulating miR-4461 expression.
lncRNA target	34876904	hsa-mir-199a	Carcinoma, Hepatocellular	Besides, PTPRG-AS1 could promote HCC through miR-199a-3p/YWHAG axis. CONCLUSIONS: Taken together, we demonstrated PTPRG-AS1 may serve as a ceRNA and reversely regulates the expression of miR-199a-3p, thus facilitating HCC tumorigenesis and metastasis, which is expected to provide new clues for the treatment of HCC.
other	34876841	hsa-mir-198	Atrial Fibrillation	Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF.
other	34876841	hsa-mir-1246	Atrial Fibrillation	Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF.
other	34876841	hsa-mir-339	Atrial Fibrillation	Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF.
genetics_overexpression_promote	34876564	hsa-mir-135a	Cardiomegaly	Furthermore, forcing miR-135a overexpression exerted a significant protective effect against cardiac hypertrophy by inhibiting the activity of its downstream target TCF7, a critical member of Wnt signaling, and the protective effect could be reversed by AMO-135a. Altogether, our study demonstrated that lncRNAA02Rik upregulation could promote cardiac hypertrophy development via modulating miR-135a expression levels and TCF7 activity.
other	34876558	hsa-mir-181d	Ovarian Neoplasms	Oncogenic microRNA-181d binding to OGT contributes to resistance of ovarian cancer cells to cisplatin.
other	34876144	hsa-mir-24	Liver Neoplasms	5p/ROCK1.
genetics_overexpression_promote	34876142	hsa-mir-155	Cholangiocarcinoma	5p overexpressing cell lines decreased the phosphorylation level of RAF, MEK and ERK, as well as the proliferation of CCA cells.
circulation_biomarker_diagnosis_ns	34876134	hsa-mir-149	Implantation Failure	3p had consistent direction changes in blood samples of patients with RIF.
circulation_biomarker_diagnosis_ns	34876134	hsa-mir-150	Implantation Failure	3p had consistent direction changes in blood samples of patients with RIF.
circulation_biomarker_diagnosis_ns	34876134	hsa-mir-342	Implantation Failure	3p had consistent direction changes in blood samples of patients with RIF.
circulation_biomarker_diagnosis_ns	34876134	hsa-mir-146b	Implantation Failure	3p had consistent direction changes in blood samples of patients with RIF.
circRNA target	34876132	hsa-mir-339	Osteosarcoma	CONCLUSIONS: CircDOCK1 can promote progression and regulate cisplatin sensitivity in OS via the miR
genetics_knock down_promote	34875555	hsa-mir-665	Lymphoma, Large B-Cell, Diffuse	Knockdown of miR-665 promoted DLBCL cell proliferation and invasion and decreased cell apoptosis, whereas miR-665 overexpression showed opposite effects on DLBCL cell malignant behaviors.
genetics_knock down_promote	34875555	hsa-mir-665	Lymphoma, B-Cell	Knockdown of miR-665 promoted DLBCL cell proliferation and invasion and decreased cell apoptosis, whereas miR-665 overexpression showed opposite effects on DLBCL cell malignant behaviors.
lncRNA target	34875451	hsa-mir-142	Cholesteatoma, Middle Ear	5p in the regulation of the inflammatory response in AMEC through its inhibitory effect on CDK5 expression, we studied the inflammatory response in HaCaT cells transfected with small interfering RNA against CDK5 (si-CDK5) and a miR
other	34875312	hsa-mir-21	Carcinoma, Hepatocellular	In addition, circRNA-001241 facilitated HCC sorafenib-resistance by regulating the miR5p/TIMP3 axis.
lncRNA target	34875217	hsa-mir-125b	Macular Degeneration	In conclusion, this study illustrated that miR-125b can protect RPE from oxidative damage via targeting Nrf2/HIF-1alpha signal pathway and potentially may serve as a therapeutic agent of AMD.
genetics_overexpression_promote	34874810	hsa-mir-506	Carcinoma, Non-Small-Cell Lung	Our results revealed that miR-506 is high expression in NSCLC cell lines, and the overexpression of miR-506 could inhibit cell viability and enhance cell apoptosis in H1299 and A549 cells.
lncRNA target	34874752	hsa-mir-196b	Mesothelioma	Conclusions: We suggest that geldanamycin has potential for the treatment of mesothelioma via regulating miR-196b-5p.
exosome	34874565	hsa-mir-379	Lymphoma, Large B-Cell, Diffuse	Four exosomal miRNAs (miR5p, miR-135a-3p, miR-4476, and miR-451a) were differentially expressed between patients with DLBCL and CCs, with an AUC of 0.78.
exosome	34874565	hsa-mir-451a	Lymphoma, Large B-Cell, Diffuse	Four exosomal miRNAs (miR
exosome	34874565	hsa-mir-135a	Lymphoma, Large B-Cell, Diffuse	Four exosomal miRNAs (miR5p, miR-135a-3p, miR-4476, and miR-451a) were differentially expressed between patients with DLBCL and CCs, with an AUC of 0.78.
genetics_knock down_suppress	34874325	hsa-let-7c	Brain Ischemia	Knockdown of circ_HECTD1 protected against cerebral ischemia injury in OGD/R-treated PC-12 cells depending on the regulation of let-7c-5p/ROCK1 axis.
genetics_overexpression_promote	34874324	hsa-mir-1	Brain Injuries, Traumatic	Downregulation of miR-31 promoted traumatic neuron injury-induced neuronal cell injury, and its overexpression did the opposite.
genetics_knock down_suppress	34874224	hsa-mir-23a	Stomach Neoplasms	In vivo, elevated miR-23a-3p restrained the volume and tumor of GC and reduced the expression of CCL22 and phosphorylated PIK3/Akt, while knockdown miR-23a-3p motivated tumor growth.
genetics_knock down_promote	34873899	hsa-mir-1270	Osteosarcoma	Taken together, knockdown of miR-1270 may inhibit the development of OS via targeting CGN.
other	34873501	hsa-mir-181d	Meningioma	Conclusions MiR-181d has potential as a biomarker for meningiomas and is associated with the tumor progression of meningiomas.
circulation_biomarker_diagnosis_up	34873439	hsa-mir-539	Cerebrovascular Occlusive Diseases	The results of this study suggested that circulating miR-539 in peripheral blood may be a potential marker for predicting blood-brain barrier permeability after ischemic stroke.
transcription factor target	34873433	hsa-mir-133b	Diabetes Mellitus	Hence, miR-133b inhibition may be a useful strategy for treating diabetic wounds.
circulation_biomarker_diagnosis_up	34873417	hsa-mir-21	Coronary Disease	Our results indicated that miR-21, CX43, and the level of inflammatory cytokines including ICAM-1 and IL-1beta were upregulated, while SPRY1 was downregulated in blood samples from CHD patients compared with the controls.
circulation_biomarker_diagnosis_up	34873417	hsa-mir-21	Depression	Our results indicated that miR-21, CX43, and the level of inflammatory cytokines including ICAM-1 and IL-1beta were upregulated, while SPRY1 was downregulated in blood samples from CHD patients compared with the controls.
genetics_overexpression_promote	34873301	hsa-mir-181a	Leukemia, Large Granular Lymphocytic	miRNA sequencing in T-LGL leukemia cases and aged-matched healthy control TEMRA cells revealed overexpression of miR-181a. By using TL1, a human T-LGL cell line, we could show that miR-181a is an actor in T-LGL leukemia, driving STAT3 activation by SOCS3 inhibition and ERK1/2 phosphorylation by DUSP6 inhibition and verified this mechanism in an independent cell line.
lncRNA target	34873163	hsa-mir-512	Breast Neoplasms	5p from the 3'-UTR of STAT1, circRPPH1 inhibited the suppressive role of miR
lncRNA target	34872582	hsa-mir-885	Adenocarcinoma of Lung	Wnt10b as a target of miR
other	34872454	hsa-mir-627	Colonic Neoplasms	Beyond that, downregulated expression of IFNG-AS1 may repress malignant progression of colon adenocarcinoma by regulating miR3p.
circulation_biomarker_diagnosis_ns	34872453	hsa-mir-410	Pulmonary Disease, Chronic Obstructive	This investigation aimed to assess the levels of serum OIP5-AS1 and micro RNA
lncRNA target	34872452	hsa-mir-25	Intervertebral Disc Degeneration	3p as a novel regulatory axis for the molecular targets of IDD therapy.
genetics_overexpression_promote	34872451	hsa-mir-340	Insulin Resistance	Furthermore, overexpression of miR
lncRNA target	34872448	hsa-mir-520d	Melanoma	In conclusion, we have found out that miR-520d-3p suppressed melanoma tumorigenesis by inhibiting ASF1B, which could be a promising target for melanoma therapy.
other	34872436	hsa-mir-504	Ischemia	In addition, microRNA-seq helped us determine that Mir504-5p was differentially expressed in ischemic flaps.
lncRNA target	34871862	hsa-mir-197	Fibrosarcoma	However, there is hardly any evidence on the involvement of tumor-suppressive miR-197 reported in our previous study in augmenting the sensitivity of fibrosarcoma cells to Dox.
transcription factor target	34871825	hsa-mir-10b	Bronchial Diseases	By referring to other previous studies, we concluded that miR-10b-5p might be a potent target in the treatment of airway diseases.
genetics_overexpression_suppress	34870753	hsa-mir-1246	Thyroid Neoplasms	Analysis of GEO data demonstrated significant miR-1246 downregulation in thyroid cancer, and we confirmed that overexpression of miR-1246 can inhibit migratory, invasive, and proliferative activity in vitro and tumor growth in vivo.
genetics_overexpression_promote	34870560	hsa-mir-144	Neonatal Sepsis	Overexpression of CASC15 may promote the inflammatory response of NS by targeted regulating the expression of miR
lncRNA target	34870557	hsa-mir-185	Colorectal Neoplasms	TEAD1 (TEA domain transcription factor1) - a major effector of the Hippo signaling was proved to serve as the target of miR
lncRNA target	34870494	hsa-mir-492	Carcinoma, Renal Cell	We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP).
lncRNA target	34870494	hsa-mir-213	Carcinoma, Renal Cell	We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP).
lncRNA target	34870494	hsa-mir-21	Carcinoma, Renal Cell	We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP).
lncRNA target	34870494	hsa-mir-383	Carcinoma, Renal Cell	We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP).
exosome	34870106	hsa-mir-28	Alzheimer Disease	METHODS: Exosomes were first isolated from CSF samples of 48 subjects (8 controls, 28 AD, and 12 FTD), followed by RNA extraction and quantitative PCR to measure the expression of miR-320a, miR
target gene	34869970	hsa-mir-199	Pancreatic Neoplasms	MiR-199 Reverses the Resistance to Gemcitabine in Pancreatic Cancer by Suppressing Stemness through Regulating the Epithelial-Mesenchymal Transition.
other	34869733	hsa-mir-483	Cushing Syndrome	3p) were differentially expressed compared to healthy dogs.
other	34869733	hsa-mir-222	Cushing Syndrome	3p) were differentially expressed compared to healthy dogs.
other	34869733	hsa-mir-126	Cushing Syndrome	3p) were differentially expressed compared to healthy dogs.
other	34869733	hsa-mir-141	Cushing Syndrome	Additionally, miR3p was expressed significantly lower (p = 0.009) in dogs with csACTs that had a histopathological Utrecht score of >/= 11 compared to those with a score of <11.
other	34869733	hsa-mir-375	Cushing Syndrome	3p) were differentially expressed compared to healthy dogs.
other	34869721	hsa-mir-29	Pasteurella Multocida Infections	Characterization of microRNA Profiles in Pasteurella multocida-Infected Rabbits and Identification of miR5p as a Regulator of Antibacterial Immune Response.
genetics_GWAS	34869683	hsa-mir-21	Obesity	Results achieved confirmed the role of epigenetics in the obesity-related cardiovascular complications and firstly supported the potential role of plasma miRNA-21 and IL-6 and NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for predicting cardiovascular risk in obesity.
other	34869393	hsa-mir-378a	Carcinoma, Hepatocellular	CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression.
lncRNA target	34869346	hsa-mir-92a	Uterine Cervical Neoplasms	miR-92a-3p promoted the malignant behavior of CC stem cells by targeting LATS1, which regulated TAZ and E-cadherin.
lncRNA target	34869311	hsa-mir-667	Osteoarthritis	Taken together, our findings demonstrate that circPan3 promotes ghrelin synthesis and chondrocyte autophagy via targeting miR
lncRNA target	34869303	hsa-mir-24	Fibrosis, Renal	Findings concur in showing that lncRNA 74.1 could induce cellular autophagy and alleviate renal fibrosis by regulating the miR
other	34869091	hsa-mir-4731	Congenital Pulmonary Airway Malformations	3p to SLAIN motif family member 1.
other	34869091	hsa-mir-454	Congenital Pulmonary Airway Malformations	3p to SLAIN motif family member 1.
other	34869091	hsa-mir-32	Congenital Pulmonary Airway Malformations	3p to SLAIN motif family member 1.
circRNA target	34869035	hsa-mir-545	Glioma	Finally, an in vivo experiment was conducted, which demonstrated that circ_0001367 inhibited glioma growth in vivo by modulating miR
exosome	34868916	hsa-mir-185	Squamous Cell Carcinoma of Head and Neck	To conclude, the findings demonstrate exosomal miR
lncRNA target	34868902	hsa-mir-489	Pancreatic Carcinoma	3p inhibited the growth of pancreatic cancer.
other	34868829	hsa-mir-7	Lyme Disease	The miR-7 level was upregulated in PDL tissues and reduced in differential PDLCs.
genetics_knock down_suppress	34868829	hsa-mir-7	Periodontitis	Conclusions Knockdown of ANRIL inhibited osteogenic differentiation via sponging miR-7 through the NF-B pathway, suggesting that ANRIL might be a therapeutic target for periodontitis.
genetics_knock down_promote	34868669	hsa-mir-485	Glioma	Besides, circ_0082375 knockdown hampered the growth of glioma growth by regulating the miR
transcription factor target	34868398	hsa-mir-190	Myocardial Reperfusion Injury	5p can reduce the inflammation and apoptosis of myocardium by targeting PHLPP1, thereby alleviating MIRI.
other	34868364	hsa-mir-20b	Breast Neoplasms	RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells.
other	34868361	hsa-mir-21	Leukemia, Myeloid, Acute	Long non-coding RNA MIR17HG sponges microRNA-21 to upregulate PTEN and regulate homoharringtonine-based chemoresistance of acute myeloid leukemia cells.
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-103a	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-16	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-191	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-210	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-106a	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-21	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
circulation_biomarker_diagnosis_ns	34868358	hsa-mir-155	Colorectal Neoplasms	The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR
other	34868237	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	The two lncRNAs ABTB1 and NPTN with the hsa-miR5p and mRNA SERPINE1 were significantly associated with resistance to EGFR-TKIs and survival in NSCLC.
circulation_biomarker_diagnosis_ns	34868211	hsa-mir-224	Cysts	These data show that peripheral blood monocyte miR
circulation_biomarker_diagnosis_ns	34868211	hsa-mir-545	Cysts	These data show that peripheral blood monocyte miR
circulation_biomarker_diagnosis_ns	34868079	hsa-mir-25	Arthritis, Rheumatoid	3p and serum levels of sTWEAK may have use in the early clinical diagnosis of RA.
circulation_biomarker_diagnosis_ns	34868079	hsa-mir-451a	Arthritis, Rheumatoid	3p and serum levels of sTWEAK may have use in the early clinical diagnosis of RA.
circulation_biomarker_diagnosis_up	34867700	hsa-mir-519a	Glioblastoma	In GB cells, circNUP98 was localized to both the nucleus and cytoplasm and it interacted with pre-mature miR-519a-3p.
genetics_overexpression_promote	34867446	hsa-mir-183	Liver Cirrhosis	Next, we used lentivirus to overexpress FOXO1 in LX-2 cells, and we found that overexpression of FOXO1 reversed the promotion of miR
other	34867172	hsa-mir-155	Epilepsy, Temporal Lobe	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
other	34867172	hsa-mir-200c	Tuberous Sclerosis	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
other	34867172	hsa-mir-155	Tuberous Sclerosis	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
other	34867172	hsa-mir-200c	Epilepsy, Temporal Lobe	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
other	34867172	hsa-mir-195	Epilepsy, Temporal Lobe	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
other	34867172	hsa-mir-195	Tuberous Sclerosis	5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms.
exosome	34866540	hsa-mir-653	Thyroid Cancer, Papillary	These results evidenced that exosomal circ007293 induced EMT and augmented the invasive and migratory abilities of PTC cells via the miR5p/PAX6 axis, suggesting that it may serve as a promising biomarker for cancer progression.
lncRNA target	34866525	hsa-mir-299	Breast Neoplasms	In conclusion, above findings conclude that lncRNA DLGAP1-AS1 promotes BC ADR-resistance through WTAP/DLGAP1-AS1/miR3p feedback loop.
other	34866368	hsa-mir-517a	Pre-Eclampsia	Further studies are required to investigate a possible role for Hsa-miR-517a/b in the pathogenesis of PE.
circRNA target	34866220	hsa-mir-1253	Prostatic Neoplasms	Simultaneously, miR-1253 hindered PCa cell progression via regulating NRBP1.
lncRNA target	34865451	hsa-mir-24	Diabetic Retinopathy	Furthermore, it may be a new research direction of PDR to validate the target mRNAs of hsa-miR
lncRNA target	34865451	hsa-mir-197	Diabetic Retinopathy	Furthermore, it may be a new research direction of PDR to validate the target mRNAs of hsa-miR
lncRNA target	34865205	hsa-mir-651	Breast Neoplasms	The aim of this study was to elucidate the role of hsa-miR-3651 for predicting of local control (LC) in early breast cancer. CONCLUSION: The current study revealed that hsa-miR-3651 is a predictor of LC in early breast cancer via its putative target protein FRMD3.
transcription factor target	34865098	hsa-mir-155	Alzheimer Disease	5p as a target for AD treatment.
exosome	34864822	hsa-mir-361	Prostatic Neoplasms	This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa.
genetics_overexpression_promote	34864645	hsa-mir-199a	Cardiotoxicity	The cardiac-specific overexpression of miR-199a-3p promoted cell cycle re-entry and cell proliferation, resulting in relief from cardiac senescence. The elevation of miR-199a-3p might provide a dual therapeutic advantage in Dox cardiotoxicity therapy by simultaneously preventing cardiac senescence and reducing the spread of senescence.
lncRNA target	34863990	hsa-mir-185	Leukemia, Myeloid, Acute	5p inhibited AML progression and downregulated AML cells' proliferation and invasion.
other	34863964	hsa-mir-145	Myocardial Infarction	RESULTS: AIFM1 expression was markedly highly elevated, while miR5p expression was significantly down-regulated in the myocardial infarction animal model and H9c2 cells under hypoxia.
other	34863964	hsa-mir-145	Myocardial Ischemia	CONCLUSION: AIFM1 may exacerbate myocardial ischemic injury by promoting inflammation and the injury of cardiomyocytes, and its up-regulation may be partly due to the down-regulation of miR5p.
lncRNA target	34863307	hsa-mir-221	Asthma	5p induced the protein expression of FOXP3, and suppressed that of SOCS1 and RORgammat in in vitro model of asthma.
genetics_overexpression_promote	34863279	hsa-mir-614	Carcinoma, Hepatocellular	In rescue assays, we confirmed that overexpression of YY1 or miR
genetics_overexpression_suppress	34863188	hsa-mir-214	Prostatic Neoplasms	RESULTS: Overexpression of miRNA
target gene	34863180	hsa-mir-130a	Carcinoma, Non-Small-Cell Lung	Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells.
lncRNA target	34863152	hsa-mir-545	Nasopharyngeal Carcinoma	All inhibiting functions generated by CRNDE down-regulation upon NPC progression could be counterbalanced or synergistically exacerbated, depending on miR
lncRNA target	34863149	hsa-mir-193b	Triple Negative Breast Neoplasms	We further demonstrate that our top candidate, miR-193b, regulates these phenotypes to an extent stronger than individual pathway inhibition, thus emphasizing that its effect on TNBC aggressiveness is mediated by the coordinated repression of these functionally interconnected pathways.
other	34862716	hsa-mir-222	Retinoblastoma	Luciferase reporter assays were performed to explore the binding between miR5p and retinoblastoma susceptibility protein (RB1) gene in VSMCs.
other	34861864	hsa-mir-653	Prostatic Neoplasms	CONCLUSIONS: Our study suggested that circSERPINA3 regulated apoptosis, autophagy and aerobic glycolysis of PCa cells by competitively binding to miR5p and recruiting BUD13.
genetics_overexpression_promote	34861847	hsa-mir-93	Urinary Bladder Neoplasms	5p overexpression may contribute to BC progression via suppressing BTG2 expression.
genetics_overexpression_promote	34861846	hsa-mir-340	Urinary Bladder Neoplasms	Functionally, overexpression of miR-340 suppressed the proliferation and induced apoptosis in BC cells, while Glut-1 reversed the suppression of proliferation or induction of apoptosis induced by miR-340.
genetics_knock down_promote	34861803	hsa-mir-873	Carcinoma, Non-Small-Cell Lung	Circ_SETD3 knockdown improved gefitinib sensitivity and repressed NSCLC cell malignancy via miR
circRNA target	34861798	hsa-mir-582	Tuberculosis	In conclusion, our results demonstrated that hsa_circ_0045474 down-regulation induced macrophage autophagy in tuberculosis via miR5p/ TNKS2 axis, implying a novel strategy to treat the occurrence of active pulmonary tuberculosis caused by immune escape of M.
transcription factor target	34861581	hsa-mir-4317	Carcinoma, Hepatocellular	Overall, our data suggest that miR-4317 is a novel tumor suppressor to suppress HCC progression through PI3K/AKT pathway by targeting ZNF436, and may serve as a prognostic biomarker and therapeutic target for HCC.
circulation_biomarker_diagnosis_ns	34861526	hsa-let-7a	Breast Neoplasms	Our biosensors were further tested using human serum spiked with the let-7a and the extracts of the breast adenocarcinoma cells spiked with and without the let-7a, respectively.
circulation_biomarker_diagnosis_ns	34861059	hsa-mir-34a	Coronary Disease	Hence, this study aimed to assess the correlation of miR-34a with disease risk, blood lipid, coronary artery stenosis, inflammatory cytokines, and cell adhesion molecules of CHD.
lncRNA target	34860809	hsa-mir-34a	Pancreatic Carcinoma	OBJECTIVES: This study aimed to enhance the sensitivity of pancreatic ductal adenocarcinoma cells by microRNA-34a (miR-34a)-mediated targeting of Notch 1. CONCLUSIONS: MicroRNA-34a sensitized pancreatic cancer cells to gemcitabine treatment by inhibiting Notch 1 signaling in pancreatic cancer stem cells, indicating that miR-34a has the potential to be developed as a novel therapeutic agent for the treatment of gemcitabine-resistant pancreatic ductal adenocarcinoma cells.
lncRNA target	34860160	hsa-mir-15a	Stomach Neoplasms	Moreover, the data suggested that SGK1 reversed the suppression effect of miR-15a-5p on gastric cancer cell migration (P < .01). Moreover, SGK1 may exert an inhibitory effect in gastric cancer by being targeted by miR-15a-5p.
lncRNA target	34860147	hsa-mir-145	Colonic Neoplasms	5p, and their expression in CC could be suppressed by miR
genetics_overexpression_promote	34859848	hsa-mir-3174	Endometrial Neoplasms	Overexpression of miR-3174 partially abolished the role of LINC00958 in accelerating the malignant phenotypes of EC cells.
genetics_overexpression_suppress	34859847	hsa-mir-4282	Carcinoma, Ovarian Epithelial	EOC patients expressing low level of miR-4282 had higher incidences of lymphatic metastasis and distant metastasis, as well as worse prognosis than those overexpressing miR-4282.
genetics_knock down_promote	34859846	hsa-mir-153	Prostatic Neoplasms	In PCa, high miRNA-153 expression and loss of PTEN expression were associated significantly with higher Gleason patterns, higher Gleason scores, and higher Grade groups.
lncRNA target	34859735	hsa-mir-1343	Carcinoma, Hepatocellular	In conclusion, ASMTL-AS1 acts as a carcinogen in HCC through competing endogenous RNA (ceRNA) activity in the miR
other	34859371	hsa-mir-148a	Breast Neoplasms	RESULTS: Upregulation of PVT1 and ROCK1, and downregulation of miR-148a-3p were observed in BC tissues and cell lines. CONCLUSION: These data demonstrated that PVT1 was upregulated and facilitated to the cell migration and invasion of BC by the regulation of miR-148a-3p and ROCK1, indicating that PVT1 may be a potential biomarker of BC diagnosis and treatment.
tissue_expression_up	34859319	hsa-mir-140	Osteoarthritis	Lnxc-CL/miR-140 was evaluated for its ability to regulate gene expression in chondrocytes in vitro and to provide in vivo therapeutic effects for knee osteoarthritis in rats.
genetics_knock down_promote	34859256	hsa-mir-44352	Liver Neoplasms	Knockdown of MIR44352HG significantly inhibited the proliferation, migration and invasion of liver cancer cells.
other	34858863	hsa-mir-148a	Uterine Cervical Neoplasms	HK2 Is a Crucial Downstream Regulator of miR-148a for the Maintenance of Sphere-Forming Property and Cisplatin Resistance in Cervical Cancer Cells.
genetics_knock down_promote	34858853	hsa-mir-338	Astrocytoma	Knockdown or deactivation of DNMT1 decreased the methylation rate of the miR
other	34858831	hsa-mir-760	Carcinoma, Non-Small-Cell Lung	mediated PI3K/AKT and MEK/ERK pathways.
other	34858518	hsa-mir-138	Osteosarcoma	OBJECTIVE: To explore the effect of miR-138 on the function of follicular helper T (Tfh) cells and the differentiation of B cells in osteosarcoma. CONCLUSION: Downregulating the expression of miR-138 in osteosarcoma can improve the dysfunction of CD4(+)CXCR5(+)Tfh cells and promote the differentiation of B cells.
other	34858418	hsa-mir-212	Intervertebral Disc Degeneration	The PKD1-miR-20b-5p-AP000797 and CCNB1-miR3p-AC079834 axes may regulate IDD.
other	34858418	hsa-mir-20b	Intervertebral Disc Degeneration	The PKD1-miR-20b-5p-AP000797 and CCNB1-miR3p-AC079834 axes may regulate IDD.
lncRNA target	34858053	hsa-mir-21	Adenocarcinoma of Lung	5p target genes, then analyzed their expression patterns as well as prognostic value in LUAD.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-192	Acquired Immunodeficiency Syndrome	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-1246	Acquired Immunodeficiency Syndrome	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-194	Acquired Immunodeficiency Syndrome	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-1246	talaromycosis	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-194	talaromycosis	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
circulation_biomarker_diagnosis_up	34858034	hsa-mir-192	talaromycosis	5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc.
other	34857901	hsa-mir-223	Atherosclerosis	HSPA7 is differentially increased in human atheroma and promotes the inflammatory transition of vascular smooth muscle cells by sponging miR-223.
circulation_biomarker_diagnosis_ns	34857759	hsa-mir-375	Tuberculosis, Gastrointestinal	3p, the pulmonary TB specific marker was found in higher amount in the plasma of ITB patients than CD while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients.
circulation_biomarker_diagnosis_ns	34857759	hsa-mir-375	Crohn Disease	3p, the pulmonary TB specific marker was found in higher amount in the plasma of ITB patients than CD while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients.
lncRNA target	34857398	hsa-mir-383	Uterine Cervical Neoplasms	CONCLUSIONS: CASC9-1 exerted influences on various biological behaviors of cervical SCC cells via targeting miR
other	34857317	hsa-mir-21	Lung Neoplasms	This work describes the unique design of a bidirectional activatable synergetic DNA machine (BAS-DNA machine) for speeded and ultrasensitive determination of microRNA-21 (miR-21), a well-known biomarker for biomedical research and early diagnosis of lung cancer.
genetics_overexpression_promote	34857012	hsa-mir-154	Osteosarcoma	CONCLUSIONS: Circ-ATAD1 is overexpressed in OS and suppresses miR
genetics_overexpression_promote	34857003	hsa-mir-613	Pigmented Paravenous Chorioretinal Atrophy	miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3'-UTR in PrCa cell lines in which HnRNPK is overexpressed. To explore the potential biological function, proliferation and colony formation of PrCa cells in vitro and tumor growth in vivo were also dramatically suppressed upon reintroduction of miR-206/miR-613.
genetics_overexpression_promote	34857003	hsa-mir-206	Pigmented Paravenous Chorioretinal Atrophy	miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3'-UTR in PrCa cell lines in which HnRNPK is overexpressed. To explore the potential biological function, proliferation and colony formation of PrCa cells in vitro and tumor growth in vivo were also dramatically suppressed upon reintroduction of miR-206/miR-613.
circulation_biomarker_diagnosis_up	34856993	hsa-mir-485	Carcinoma, Non-Small-Cell Lung	5p is downregulated in both cancerous cell lines and peripheral blood serum isolated from NSCLC patients compared to reciprocal control groups.
exosome	34856955	hsa-mir-107	Stomach Neoplasms	CONCLUSIONS: These findings demonstrated that exosome-transmitted miR-107 significantly enhanced the sensitivity of resistant gastric cancer cells to chemotherapeutic agents by mediating the HMGA2/mTOR/P-gp axis and exosomal miR-107 may be a novel target in gastric cancers treatment.
other	34856948	hsa-mir-6838	Stomach Neoplasms	CONCLUSIONS: Hsa_circ_0008434 may promote GC proliferation, invasion and migration by regulating the expression of miR-6838 and USP9X.
other	34856848	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	Overall, TDRG1 exerts carcinogenic effects in NSCLC by regulating the miR5p/KLF5 axis.
other	34856073	hsa-mir-34a	Breast Neoplasms	Kaplan-Meier plotter analysis found that resveratrol-induced expression changes in key RNAs, such as E2F2, JUN, FOS, BRCA1, CDK1, CDKN1A, TNF, and hsa-miR-34a-5p, significantly improved the prognosis of breast cancer patients, which was further verified using real-time quantitative PCR (qPCR) and western blotting.
other	34856019	hsa-mir-210	Corneal Injuries	In addition, miR-210 is decreased after corneal injury while EphA2 is increased.
lncRNA target	34855515	hsa-mir-203a	Acute Lung Injury	Bioinformatics analysis, ELISA assay, quantitative reverse transcription polymerase chain reaction analysis, biotinylated RNA pull-down assay, apoptosis test, and Western blot analysis demonstrated that the LINC01194 could act as a microRNA (miR) miR-203a-3p sponge to activate the inflammatory response in LPS-induced ALI model through post-transcriptional upregulation of macrophage inflammatory protein (MIP-2).
genetics_overexpression_promote	34855100	hsa-mir-4731	Choriocarcinoma	5p elevation or HIF3A suppression reversed the promoting effect of OGFRP1 overexpression on the malignant behaviors of ropivacaine-treated choriocarcinoma cells.
circulation_biomarker_diagnosis_up	34855075	hsa-mir-155	Graves Disease	Though there is a trend of elevation of miR- 155 in THD than in simple hyperthyroidism patients, we did not find statistically significant differences in the expression of these miRNAs in the blood of THD patients, but we found that miR-155 was significantly up-regulated in patients with Graves' disease with or without THD in comparison with healthy controls. Thus, miR-155 can serve as a novel biomarker for Graves' disease and can play important roles in pathogenesis of Graves' disease.
lncRNA target	34854520	hsa-mir-339	Cardiomegaly	Valosin-containing protein (VCP), a suppressor of cardiac hypertrophy via inhibiting mechanistic target of rapamycin (mTOR) signaling, was validated as a target of miR
lncRNA target	34854396	hsa-mir-125a	Arthritis, Rheumatoid	CONCLUSIONS: This study suggests that miR-125a-3p could inactivate the Wnt/beta-catenin and NF-kappaB pathways to reduce the proliferation and inflammation response of RA-FLS via targeting MAST3.
lncRNA target	34854395	hsa-mir-1207	Spinal Cord Injuries	Moreover, RP11-253E3.3-hsa-miR5p-FOXO3 axis may be a promising therapeutic target for skeletal muscle atrophy after SCI.
lncRNA target	34854395	hsa-mir-1207	Muscular Atrophy	Moreover, RP11-253E3.3-hsa-miR5p-FOXO3 axis may be a promising therapeutic target for skeletal muscle atrophy after SCI.
other	34854361	hsa-mir-16	Polycystic Ovary Syndrome	Our study revealed miR-16 regulates Apelin13 to mediate the PI3K/Akt signalling pathway and, thereby mediates PCOS progression.
circulation_biomarker_diagnosis_down	34854318	hsa-mir-381	Colorectal Neoplasms	3p were downregulated in CRC patients as well as in early-stage patients compared with healthy donors; they could serve as circulating biomarkers of diagnosis, including early diagnosis, for CRC, possessing favorable diagnostic efficiency.
circRNA target	34854210	hsa-mir-422a	Diabetic Nephropathies	Above results demonstrated that the high glucose-induced exo-circ_0125310 promoted cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R/p38 axis.
genetics_knock down_suppress	34854069	hsa-mir-766	Thyroid Cancer, Papillary	Overexpression of miR
circulation_biomarker_diagnosis_ns	34854020	hsa-mir-6879	Thyroid Cancer, Papillary	CONCLUSIONS The two plasma exosomal miRNAs (miR
circulation_biomarker_diagnosis_ns	34854020	hsa-mir-6774	Thyroid Cancer, Papillary	CONCLUSIONS The two plasma exosomal miRNAs (miR
other	34853722	hsa-mir-494	Atherosclerosis	We have previously shown that treatment with third-generation antisense oligonucleotides against miR3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage content in established plaques.
lncRNA target	34853647	hsa-mir-7	Spasm	CONCLUSION: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa.
lncRNA target	34853647	hsa-mir-7	Metaplasia	CONCLUSION: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa.
genetics_knock down_promote	34853631	hsa-mir-195	Neuroblastoma	The inhibitory effects of hsa_circ_0013401 knockdown suppressed the proliferation, migration, and invasion and induced the apoptosis and autophagy of NB cells by targeting miR-195 to downregulate PAK2 expression.
other	34853624	hsa-mir-662	Atrial Fibrillation	Subsequently, the hsa-miRCREB1-VIP axis was obtained, and the role of CREB1 and VIP in the development of AF after MI was further revealed by single-cell analysis and prediction model construction.
exosome	34853524	hsa-mir-216a	Arthritis, Rheumatoid	CONCLUSION: We concluded that MSC-derived exosomal circFBXW7 suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA rats via sponging miR-216a-3p and release the activation of HDAC4.
lncRNA target	34853466	hsa-mir-139	Esophageal Squamous Cell Carcinoma	In conclusion, GTF2E2 may serve as a novel biomarker for recurrence after surgery and a potential therapeutic target for ESCC patients, and it promotes ESCC progression via miR
exosome	34853307	hsa-mir-18b	Breast Neoplasms	Targeting CAFs-derived exosome miR-18b may be a potential treatment option to overcome breast cancer progression.
lncRNA target	34852712	hsa-mir-216a	Urinary Bladder Neoplasms	In conclusion, circFLNA inhibits the malignant phenotype of BCa cells and their stemness through miR-216a-3p/BTG2, thus suppressing BCa progression.
circRNA target	34852711	hsa-mir-298	Endometrial Neoplasms	Our rescue assay data further revealed that hsa_circ_0005797 silencing inhibited EC cells proliferation and invasion via miR-298/CTNND1 signaling. In conclusion, our study confirmed hsa_circ_0005797 is a poor prognostic factor for EC and modulates EC phenotypes by regulating the hsa_circ_000579/miR-298/CTNND1 signaling, which provides potential treatment targets for EC.
exosome	34852710	hsa-mir-3977	Multiple Myeloma	Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR
exosome	34852710	hsa-mir-6758	Multiple Myeloma	Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR
exosome	34852710	hsa-mir-6804	Multiple Myeloma	Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR
genetics_knock down_suppress	34852705	hsa-mir-567	Stomach Neoplasms	This study aims to investigate the potential clinical function of long non-coding RNA CERS6-AS1 (lncRNA CERS6-AS1) integrated miR-567 in gastric cancer. After CERS6-AS1 knockdown, the expression level of miR-567 in gastric cancer tissues decreased, while the expression level of miR-567 increased.
circulation_biomarker_diagnosis_up	34851581	hsa-mir-223	Stomach Neoplasms	CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC.
circulation_biomarker_diagnosis_up	34851581	hsa-mir-25	Stomach Neoplasms	CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC.
circulation_biomarker_diagnosis_up	34851581	hsa-mir-21	Stomach Neoplasms	CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC.
transcription factor target	34851490	hsa-mir-451a	Cardiomyopathies	In conclusion, these results indicate that miR-451a acts as a novel regulator of Ang II-induced cardiac fibrosis and inflammation by directly targeting TBX1, and may be a promising therapeutic target for treating hypertensive cardiac diseases.
transcription factor target	34851490	hsa-mir-451a	Inflammation	In conclusion, these results indicate that miR-451a acts as a novel regulator of Ang II-induced cardiac fibrosis and inflammation by directly targeting TBX1, and may be a promising therapeutic target for treating hypertensive cardiac diseases.
lncRNA target	34851489	hsa-mir-410	Brain Ischemia	Conclusion Exhausting TUG1 could alleviate CI/R-induced inflammatory injury and apoptosis in brain tissues and BMECs via targeting miR-410/FOXO3 axis, suggesting an innovative perspective from cerebrovascular endothelial cells in the pathogenesis and treatment of CI/R.
lncRNA target	34851489	hsa-mir-410	Reperfusion Injury, Cerebral Ischemia	Conclusion Exhausting TUG1 could alleviate CI/R-induced inflammatory injury and apoptosis in brain tissues and BMECs via targeting miR-410/FOXO3 axis, suggesting an innovative perspective from cerebrovascular endothelial cells in the pathogenesis and treatment of CI/R.
other	34851479	hsa-mir-223	von Hippel-Lindau Disease	CONCLUSIONS: The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC.
other	34851479	hsa-mir-223	Carcinoma, Renal Cell	CONCLUSIONS: The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC.
lncRNA target	34850965	hsa-mir-515	Stomach Neoplasms	CONCLUSION: CircAKT3 promotes the malignant development of GC by activating SLC1A5 expression via targeting miR5p.
other	34850963	hsa-mir-466g	Liver Cirrhosis	Taken together, lncMBI52 induced liver fibrosis by regulating the miR466g/SMAD4 axis, which may provide a new possible strategy for liver fibrosis.
genetics_overexpression_promote	34850961	hsa-mir-204	Necrobiotic Disorders	Moreover, NEAT1 overexpression counteracted miR204 mimicinduced injury, BRCC3 expression and NLRP3 inflammasome activationdependent pyroptosis.
transcription factor target	34850958	hsa-mir-451	Leukemia, Myeloid, Acute	In conclusion, these results indicated that corilagin induced apoptosis and inhibited autophagy in HL60 cells by regulating the miR451/HMGB1 axis, and corilagin may be a novel therapeutic drug for the treatment of AML.
other	34850884	hsa-mir-4293	Femur Head Necrosis	MIR4293 regulates a PPARG-related adipogenesis pathway relevant to S-ONFH.
other	34850884	hsa-mir-4293	Lupus Erythematosus, Systemic	MIR4293 regulates a PPARG-related adipogenesis pathway relevant to S-ONFH.
circulation_biomarker_diagnosis_ns	34850865	hsa-mir-27b	Non-alcoholic Fatty Liver Disease	Finally, we confirmed that circulating miR-34a-5p and miR
circulation_biomarker_diagnosis_ns	34850865	hsa-mir-375	Non-alcoholic Fatty Liver Disease	Finally, we confirmed that circulating miR-34a-5p and miR
circulation_biomarker_diagnosis_ns	34850865	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Finally, we confirmed that circulating miR-34a-5p and miR
other	34850664	hsa-mir-3681	Adenocarcinoma of Lung	3p to contribute to the malignant behaviors of LUAD cells.
circRNA target	34850570	hsa-mir-433	Carcinoma, Non-Small-Cell Lung	3p inhibitor reversed the inhibiting influence of circ_0008037 silencing on proliferation, migration, invasion, and the Warburg effect of NSCLC cells.
genetics_knock down_promote	34850542	hsa-mir-338	Cystadenocarcinoma, Serous, Ovarian	We determine that knockdown of SBF2-AS1 inhibits SOC cell proliferation and invasion by sponging miR
lncRNA target	34850451	hsa-mir-195	Coronary Disease	BACKGROUND: Long noncoding RNA urothelial cancer-associated 1 (lnc-UCA1) targets microRNA-26a (miR-26a) and microRNA-195 (miR-195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility.
lncRNA target	34850451	hsa-mir-26a	Coronary Disease	BACKGROUND: Long noncoding RNA urothelial cancer-associated 1 (lnc-UCA1) targets microRNA-26a (miR-26a) and microRNA-195 (miR-195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility.
transcription factor target	34850093	hsa-mir-144	Arthritis, Rheumatoid	3p could aggravate chondrocyte injury inflammatory response in RA via BMP2/PI3K/Akt axis.
genetics_overexpression_promote	34850088	hsa-mir-106b	Arthritis, Rheumatoid	CONCLUSIONS: miR-106b overexpression suppresses synovial inflammation and alleviates synovial damage; thus, it may be served as a potential therapeutic target for RA patients.
lncRNA target	34850055	hsa-mir-206	Myocardial Reperfusion Injury	CONCLUSIONS: Our results elucidated that remifentanil alleviated myocardial I/R injury by miR3p/TLR4/NF-kappaB signalling axis.
circulation_biomarker_diagnosis_ns	34849458	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	The sensing performance and diagnostic performance of the mCLN assay were investigated using non-small cell lung cancer (NSCLC) as the disease model and exosomal microRNA-21 and TTF-1 mRNA as the biomarkers. The mCLN assay successfully distinguished NSCLC from normal controls by detecting significantly higher microRNA-21 and TTF-1 mRNA levels in exosomes from both NSCLC patient serum samples and A549 NSCLC cells than those from normal controls and BEAS-2B normal bronchial epithelial cells.
exosome	34849458	hsa-mir-21	Lung Neoplasms	The sensing performance and diagnostic performance of the mCLN assay were investigated using non-small cell lung cancer (NSCLC) as the disease model and exosomal microRNA-21 and TTF-1 mRNA as the biomarkers.
transcription factor target	34849149	hsa-mir-183	Breast Neoplasms	5p supplies a promising target for BC therapy.
genetics_GWAS	34848810	hsa-mir-618	Colorectal Neoplasms	In summary, polymorphism rs2682818 participated in the progression of CRC via affecting the expression of mature miR-618 in CRC cells, and miR-618 inhibited the progression of CRC via targeting TIMP1expression.
exosome	34848693	hsa-mir-1249	Diabetes Mellitus, Type 2	This study reveals an emerging role for NK-derived exosomal miR3p in remission of insulin resistance, and provides a series of potential therapeutic targets in type 2 diabetes.
exosome	34848693	hsa-mir-1249	Inflammation	This study reveals an emerging role for NK-derived exosomal miR3p in remission of insulin resistance, and provides a series of potential therapeutic targets in type 2 diabetes.
genetics_overexpression_promote	34848471	hsa-mir-188	Breast Neoplasms	Moreover, miRNA-3188 overexpression sensitized breast cancer cells to ionizing radiation (IR) by down-regulating Rictor and p-AKT.
lncRNA target	34848464	hsa-mir-181b	Ehlers-Danlos Syndrome, musculocontractural type 1	CONCLUSION: CTAB attenuates the mesenchymal characteristics through upregulation of TIMP3 by inhibiting the canonical TGF-beta/Smad/miR-181b/TIMP3 signaling involved in extracellular matrix remodeling in SCC4 cells and might be a promising anti-metastatic therapeutic agent for TSCC.
lncRNA target	34848464	hsa-mir-181b	Carcinoma, Basal Cell	CONCLUSION: CTAB attenuates the mesenchymal characteristics through upregulation of TIMP3 by inhibiting the canonical TGF-beta/Smad/miR-181b/TIMP3 signaling involved in extracellular matrix remodeling in SCC4 cells and might be a promising anti-metastatic therapeutic agent for TSCC.
genetics_overexpression_promote	34848272	hsa-mir-338	Glioma	Additionally, silencing MYT1L produced similar effects as overexpressing miRNA
other	34847936	hsa-mir-145	Ovarian Neoplasms	5p to improve the expression of ZEB2 in ovarian cancer.
other	34847936	hsa-mir-383	Ovarian Neoplasms	5p to improve the expression of ZEB2 in ovarian cancer.
circulation_biomarker_diagnosis_up	34847832	hsa-mir-188	Diabetic Nephropathies	3p antagonists is expected to be an effective therapeutic strategy for DN.Abbreviations DN: diabetic nephropathy; Type I DN: DN in Type I diabetes; STZ: streptozocin; ROS: reactive oxygen species; NcRNAs: non-coding RNAs; UTR: untranslated regions; NC: negative control; BUN: blood urea nitrogen; BUA: blood uric acid; Ucr: urine creatinine; Scr: serum creatinine; PAS: Periodic Acid-Schiff; IF: Immunofluorescence; FISH: Fluorescence in situ hybridization; TUG1: taurine upregulated gene 1; GPX: Glutathione Peroxidase; GPX4: glutathione peroxidase 4; EMT: epithelial-mesenchymal transition.
exosome	34847690	hsa-mir-136	Fractures, Bone	CONCLUSION: BMSC-derived exosomes carrying miR
other	34846081	hsa-mir-5787	Colorectal Neoplasms	We found that the expression of miRNA-5787 was correlated with reciprocal expression of two mRNAs, that is, SRRM2 and POLR2J3, in SSL samples.
other	34846081	hsa-mir-6753	Colorectal Neoplasms	3p/OLFM4, were retained in CRC with an MSI phenotype.
other	34846081	hsa-mir-182	Colorectal Neoplasms	In TSA samples, two pairs of miRNAs/mRNAs showing opposite expression patterns, that is, miRNA5p/ETF1 and miRNA-200b-3p/MYB, were identified.
other	34846081	hsa-mir-222	Colorectal Neoplasms	3p/OLFM4, were retained in CRC with an MSI phenotype.
other	34846081	hsa-mir-200b	Colorectal Neoplasms	In TSA samples, two pairs of miRNAs/mRNAs showing opposite expression patterns, that is, miRNA5p/ETF1 and miRNA-200b-3p/MYB, were identified.
transcription factor target	34845965	hsa-mir-37	Inflammation	miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats.
transcription factor target	34845965	hsa-mir-375	Osteoarthritis	miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats.
transcription factor target	34845965	hsa-mir-375	Inflammation	miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats.
transcription factor target	34845965	hsa-mir-37	Osteoarthritis	miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats.
circRNA target	34845670	hsa-mir-345	Pre-Eclampsia	Our data demonstrate the upregulation of circ_0008726 in PE placenta, which inhibits the migration, invasion, and EMT of HTR-8/SVneo cells by targeting miR
other	34845193	hsa-mir-33a	Myocardial Reperfusion Injury	Circ-NNT promotes pyroptosis and myocardial I/R injury by acting as a miR-33a-5p sponge to regulate USP46.
circRNA target	34845164	hsa-mir-149	Breast Neoplasms	Interference of circATXN7 inhibited breast cancer progression and doxorubicin resistance via mediating miR
lncRNA target	34845162	hsa-mir-107	Squamous Cell Carcinoma of Head and Neck	Circ_0005033 was oncogenic in LSCC by regulating cell progression and Cisplatin sensitivity at least via miR-107/IGF1R axis.
other	34844630	hsa-mir-193b	Colorectal Neoplasms	Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p.
circRNA target	34844614	hsa-mir-30	Carcinoma, Hepatocellular	CONCLUSIONS: The acceleration of HCC progression and metastasis by circSLC7A11 through the circSLC7A11/miR
other	34844494	hsa-mir-124	Glaucoma	based advanced therapies might be a potential avenue in the treatment of glaucomatous neurodegeneration.
lncRNA target	34844105	hsa-mir-378b	Liver Diseases	A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD). Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110alpha and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance.
lncRNA target	34844105	hsa-mir-378b	Adrenoleukodystrophy	A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD). Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110alpha and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance.
lncRNA target	34844105	hsa-mir-378b	Liver Diseases, Alcoholic	A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD).
circulation_biomarker_diagnosis_ns	34843716	hsa-mir-194	Acute Liver Injury	The two microRNAs miR-192 and miR-194 are abundantly expressed in the liver and are considered serum biomarkers of liver injury.
other	34843522	hsa-mir-338	Glioblastoma	In conclusion, H19 and hsa-miR3P regulate NRP1 expression, and this pathway plays an important role in GBM.
transcription factor target	34843094	hsa-mir-199a	Cardiomyopathies	miR-199a-5p acted as an inhibitor directly targeted hypoxia-inducible factor-1 (HIF1alpha) expression, which was higher in the cardiomyocyte injury model than that in healthy myocardial cells.
circulation_biomarker_diagnosis_ns	34843038	hsa-mir-574	Liver Cirrhosis	5p expression in serum exosomes is positively correlated with collagen deposition and HSC activation in liver tissues during liver fibrosis.Serum exosomes potentially activate HSC through the transfer of miR
other	34842937	hsa-mir-342	Liver Neoplasms	OBJECTIVE: This study aims to explore the effects of miR3p on liver cancer stem cells (LCSC) and related mechanism.
genetics_knock down_promote	34842045	hsa-mir-338	Stomach Neoplasms	5p inhibitor or METTL3 overexpression could rescue the inhibitory effect of LINC00240 knockdown on cell proliferation and migration, and inhibit the apoptosis induction in GC cells.
circulation_biomarker_diagnosis_ns	34841929	hsa-mir-18a	Atherosclerosis	ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894.
lncRNA target	34841662	hsa-mir-576	Colorectal Neoplasms	CONCLUSIONS: Hsa_circ_0001666 suppresses CRC progression through the miR
lncRNA target	34841440	hsa-mir-16	Ischemia	Further experiments revealed that GATA4 could bind to the promoter region of SNHG1 and subsequently regulated the expression levels of SNHG1, indicating the important role of the positive feedback loop of SNHG1/miR165p/GATA4 in cardiomyocyte ischemic injury. To conclude, the present study revealed the protective effect of the SNHG1/miR165p/GATA4 positive feedback loop on cardiomyocyte injury induced by H/R and provided a potential therapeutic target for ischemic cardiomyocyte injury.
transcription factor target	34841435	hsa-mir-671	Carcinoma, Non-Small-Cell Lung	The proliferative, migratory and invasive abilities of NSCLC cells were suppressed following transfection with miR6715p mimics and promoted by the miR6715p inhibitor compared with those in the respective control groups.
other	34841287	hsa-mir-216a	Pancreatic Carcinoma	Collectively, our study gives insights into how beta-cell mass and acinar cell growth are modulated by a pancreas-specific miRNA and also suggests miR-216a as a potential biomarker for diagnosis of pancreatic diseases.
transcription factor target	34840985	hsa-mir-125b	Stomach Neoplasms	The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively.
transcription factor target	34840985	hsa-mir-199a	Stomach Neoplasms	The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively.
transcription factor target	34840985	hsa-mir-199b	Stomach Neoplasms	The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively.
genetics_knock down_promote	34839824	hsa-mir-342	Carcinoma, Non-Small-Cell Lung	3p overexpression suppressed the malignant behaviors of NSCLC cells largely by downregulating ZEB2.
circulation_biomarker_diagnosis_up	34839589	hsa-mir-20b	Duane Retraction Syndrome	RESULTS: CircZNF532 and STAT3 were upregulated but miR-20b-5p was downregulated in the serum samples of patients with DR and HG-induced ARPE-19 cells.
lncRNA target	34839459	hsa-mir-136	Reperfusion Injury, Cerebral Ischemia	In conclusion, we demonstrated that SNHG12 acts as a ceRNA of miR5p, thereby targets and regulates the expression of Bcl-2, which attenuates cerebral ischemia/reperfusion injury via activation of the PI3K/AKT pathway.
other	34839449	hsa-mir-19a	Prostatic Neoplasms	CONCLUSIONS: Collectively, our results uncover a previously unrecognized novel mechanism on PCA3 upregulation in prostate cancer and proved that miR-19a and miR-421 might be responsible for the increased expression of PCA3, indicating that both miRNAs might be novel candidates for prostate cancer diagnosis and therapy.
other	34839449	hsa-mir-421	Prostatic Neoplasms	CONCLUSIONS: Collectively, our results uncover a previously unrecognized novel mechanism on PCA3 upregulation in prostate cancer and proved that miR-19a and miR-421 might be responsible for the increased expression of PCA3, indicating that both miRNAs might be novel candidates for prostate cancer diagnosis and therapy.
target gene	34839107	hsa-mir-362	Ovarian Neoplasms	miR-362-3p suppresses ovarian cancer by inhibiting LRP8.
exosome	34839044	hsa-mir-223	Supranuclear Palsy, Progressive	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-21	Parkinson Disease	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-199a	Parkinson Disease	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-199a	Supranuclear Palsy, Progressive	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-22	Supranuclear Palsy, Progressive	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-22	Parkinson Disease	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-425	Parkinson Disease	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-21	Supranuclear Palsy, Progressive	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-425	Supranuclear Palsy, Progressive	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
exosome	34839044	hsa-mir-223	Parkinson Disease	5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR
genetics_knock down_promote	34838997	hsa-mir-195	Liver Cirrhosis	3p inhibit the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN), a negative regulator of the PI3K/Akt/mTOR signaling pathway in liver fibrosis, thereby contributing to HSC activation and proliferation and promoting the expression of profibrotic genes, such as alpha-SMA and collagen I, in LX-2 cells, which accelerates the accumulation of fibrous extracellular matrix deposition in the liver, while knockdown of miR
other	34838994	hsa-mir-146a	Acute Lung Injury	Free radical scavenging cerium oxide nanoparticles (CNP) conjugated to the anti-inflammatory microRNA-146a (miR146a), termed CNP-miR146a, have been shown to prevent acute lung injury in a pre-clinical model.
exosome	34838826	hsa-mir-942	Adenocarcinoma of Lung	Mechanistically, exosomal miR-942 regulates FOXO1 protein expression by binding to the 3'-UTR region of FOXO1 and further alleviates beta-catenin inhibition in LUAD cells.
lncRNA target	34838715	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Finally, we found a strong association of CRTC2, miR-34a and mTORC1 activity in the NAFLD patients in humans, demonstrating a conservation of signaling pathways among species. CONCLUSIONS These data collectively suggest that diet-induced activation of CRTC2 instigates the progression of NAFLD by activating miR-34a-mediated lipid accumulation in the liver via the simultaneous induction of lipogenesis and inhibition of lipid catabolism.
lncRNA target	34838479	hsa-mir-182	Colorectal Neoplasms	CONCLUSION: E2F4-stimulated AGAP2-AS1 aggravated CRC development through regulating miR
circulation_biomarker_diagnosis_ns	34838331	hsa-mir-155	COVID-19	Beside the routine laboratory work and chest computed tomography (CT) scans of COVID-19 patients, plasma miR-155 expression level was measured using reverse transcription quantitative real-time PCR (RT-qPCR) technique.
lncRNA target	34838052	hsa-mir-7	Non-alcoholic Fatty Liver Disease	CONCLUSIONS: Hepatic sEVs contribute to endothelial hyperpermeability in coronary microvessels by delivering novel-miR-7 and targeting the LAMP1/Cathepsin B/NLRP3 inflammasome axis during NAFLD.
genetics_overexpression_suppress	34838029	hsa-mir-29c	Cachexia	Overexpression of miR-29c mitigated the cachectic phenotype.
genetics_overexpression_suppress	34838029	hsa-mir-29c	Leukemia	Overexpression of miR-29c mitigated the cachectic phenotype.
target gene	34838007	hsa-let-7a	Breast Neoplasms	Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4.
other	34837947	hsa-mir-1182	Ovarian Neoplasms	circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway.
other	34837929	hsa-mir-98	Breast Neoplasms	In clinical research, we found that decreased miR5p level or increased IGF2 level significantly associated with poor treatment response and poor overall survival (OS), poor recurrence free survival (RFS) and poor distant metastasis-free survival (DMFS) in HER2-positive breast cancer.
other	34837916	hsa-mir-146a	Primary Myelofibrosis	CONCLUSION: miR-146a rs2431697 TT genotype is associated with high risk of MF progression in MPN patients.
other	34837916	hsa-mir-146a	Bone Marrow Myelofibrosis	CONCLUSION: miR-146a rs2431697 TT genotype is associated with high risk of MF progression in MPN patients.
circulation_biomarker_prognosis_up	34837907	hsa-mir-106a	Breast Neoplasms	METHODS: Sera and plasma of 30 normal women and 50 women with breast carcinoma were assayed for MiR-106a by RT-qPCR as well as levels of Hb, WBCs and platelets count and RAF-1 by solid phase enzyme-linked immunosorbent assay (ELISA).
genetics_knock down_promote	34837887	hsa-mir-524	Laryngeal Neoplasms	Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma.
circulation_biomarker_diagnosis_ns	34837851	hsa-mir-222	Myocardial Infarction	Moreover, serum miR-222 levels were significantly reduced in MI patients, as well as in MI patients that were readmitted to the hospital and/or died compared to those not.
other	34837760	hsa-mir-23	Glioblastoma	3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1.
other	34837760	hsa-mir-19b	Glioblastoma	3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1.
other	34837760	hsa-mir-183	Glioblastoma	3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1.
other	34837760	hsa-mir-98	Glioblastoma	3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1.
other	34837708	hsa-mir-16	Breast Neoplasms	High variance in the stability value (SV) of miR-16 expression levels confirmed its inappropriateness as a control gene in breast cancer.
other	34837692	hsa-mir-378a	Uterine Cervical Neoplasms	The core gene granzyme B (GZMB) was screened and the CC-associated regulatory axis, GZMB/ miR-378a/TRIM52-AS1, was constructed, which may promote CC progression, and further experimentation is needed to validate these results.
circRNA target	34837683	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	CONCLUSION: This work reveals that circ_0000517 is implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR
circRNA target	34837683	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	CONCLUSION: This work reveals that circ_0000517 is implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR
other	34837628	hsa-mir-29a	Peripheral Nerve Injuries	Here, we examine the temporal expression patterns of miR-29a-3p after peripheral nerve injury and demonstrate significant up-regulation of miR-29a-3p in injured sciatic nerves.
other	34837628	hsa-mir-29a	Sciatic Neuropathy	Our results disclose the vital role of miR-29a-3p/PMP22 in regulating Schwann cell phenotype following sciatic nerve injury and shed light on the mechanistic basis of peripheral nerve regeneration.
circulation_biomarker_diagnosis_ns	34837469	hsa-mir-21	Lung Neoplasms	CONCLUSION: MicroRNA-21 in serum or sputum was a promising biomarker for lung cancer identification with relative high diagnostic sensitivity and specificity.
exosome	34837453	hsa-mir-450b	Adenocarcinoma of Lung	A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD.
exosome	34837453	hsa-mir-615	Adenocarcinoma of Lung	A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD.
exosome	34837453	hsa-mir-106b	Adenocarcinoma of Lung	A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD.
exosome	34837453	hsa-mir-125a	Adenocarcinoma of Lung	A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD.
circulation_biomarker_diagnosis_ns	34837150	hsa-mir-1290	Hyperlipidemias	METHODS AND RESULTS: The current study showed that the expressions of miR-1290 were high in serum of patients with hyperlipidemia.
other	34837150	hsa-mir-1290	Angelman Syndrome	However, the role of miR-1290 in atherosclerosis (AS) is still unclear.
other	34837147	hsa-mir-1280	Colorectal Neoplasms	CONCLUSION: The present study demonstrated that low expression of tRF/miR-1280, tRNA-Val(AAC/CAC), and tRNA-Asp(GTC) was significantly associated with metastatic stage and more aggressive tumor behavior of CRC disease.
lncRNA target	34837127	hsa-mir-17	Wounds and Injuries	These results exhibited that circ_0084443 suppressed the TGF-beta1-induced keratinocyte migration by regulating the miR3p/FOXO4 axis, suggesting the application potential of circ_0084443 in wound-healing-related diseases.
genetics_knock down_promote	34837026	hsa-mir-199a	Ovarian Neoplasms	We established DDR1 to be a direct target of miR-199a-5p and that ST09-induced DDR1 loss in these ovarian cancer cells resulted in the inactivation of its downstream MMP activation, migration, EMT, and prosurvival NF-kappaB pathway.
genetics_overexpression_promote	34836796	hsa-mir-181b	Fatty Liver, Alcoholic	RESULTS: MiR-181b-5p and PRMT1 were elevated while PIAS1 was reduced in AFLD rat liver tissues, miR-181b-5p inhibition, PIAS1 overexpression or PRMT1 inhibition improved liver function, attenuated inflammation, oxidative stress, pathological changes and hepatocyte apoptosis in AFLD rat liver tissues.
transcription factor target	34836745	hsa-mir-22	Hypertension, Pulmonary	3p as a regulator can be targeted by osthole to greatly restore dysregulated lipid metabolism thus to alleviate pulmonary vascular remodeling in PAH, which provides novel insight into the potential therapeutic target for PAH, further highlights the development potential of osthole derived new drug against PAH.
transcription factor target	34836745	hsa-mir-22	Vascular Remodeling	3p as a regulator can be targeted by osthole to greatly restore dysregulated lipid metabolism thus to alleviate pulmonary vascular remodeling in PAH, which provides novel insight into the potential therapeutic target for PAH, further highlights the development potential of osthole derived new drug against PAH.
lncRNA target	34836544	hsa-mir-148a	Ovarian Neoplasms	CONCLUSION: SNHG20 promoted invasion and migration of OC via targeting miR-148a/ROCK1 axis.
other	34834557	hsa-mir-101	Mesothelioma, Malignant	3p due to a significant association of its higher expression and increased overall survival (OS) of MM patients.
genetics_overexpression_promote	34834139	hsa-mir-654	Carcinoma, Renal Cell	5p overexpression or YY1 inhibition recovered ccRCC cell functions that had been previously impaired by LINC02532 overexpression.
transcription factor target	34834018	hsa-mir-370	Obesity	3p may result from the inhibition of saturated fatty acids that promote the accumulation of polyunsaturated fatty acids.
other	34832969	hsa-mir-223	Alzheimer Disease	5p expression is increased in AD, but this does not result in down-regulation of NLRP3 inflammasome expression and of IL-1beta and IL-18 production.
other	34832969	hsa-mir-7	Alzheimer Disease	5p expression is increased in AD, but this does not result in down-regulation of NLRP3 inflammasome expression and of IL-1beta and IL-18 production.
other	34831451	hsa-mir-22	Diabetes Mellitus	MiR3p was significantly downregulated in diabetic SMGs and HG-treated SMG-C6 cells.
other	34831427	hsa-mir-27a	Simpson-Golabi-Behmel syndrome type 1	Both strands of miR-27a, miR-27a-3p and -5p, were downregulated during the adipogenic differentiation of Simpson-Golabi-Behmel syndrome (SGBS) cells, human multipotent adipose-derived stem cells (hMADS), and human primary adipose-derived stromal cells (hASCs).
transcription factor target	34831374	hsa-mir-208a	Mitochondrial Diseases	MiR 208a may be a therapeutic target to promote mitochondrial biogenesis in chronic diseases associated with mitochondrial defects.
other	34831374	hsa-mir-208a	Diabetes Mellitus	In summary, miR 208a regulates mitochondrial biogenesis and function in cardiomyocytes exposed to diabetic conditions.
transcription factor target	34831374	hsa-mir-208a	Chronic Disease	MiR 208a may be a therapeutic target to promote mitochondrial biogenesis in chronic diseases associated with mitochondrial defects.
transcription factor target	34831232	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	Inhibition of miR
tissue_expression_ns	34831232	hsa-mir-155	Biotinidase Deficiency	Our studies suggest that miR5p is involved in BTLA deficiency, affecting proliferation of CLL B cells, which may be one of the mechanisms responsible for CLL pathogenesis.
transcription factor target	34831071	hsa-mir-2478	Melanoma	We found that Rap1a is a direct target gene of miR-2478 in melanoma cells and melanocytes.
lncRNA target	34831059	hsa-mir-17	Pulmonary Fibrosis	This study assessed the role of miR17-92 in IPF-fibroblast proliferation and its modification by treprostinil. These data suggest that proliferation control via miR17-92 and C/EBP-beta is disrupted in IPF-fibroblasts.
transcription factor target	34831008	hsa-mir-146a	Mycosis Fungoides	We found miR-146a and miR-21 to be significantly upregulated, and miR-708 the most significantly downregulated miR in LCT-MF. Moreover, our data indicated that miR-146a, -21 and -708 are associated with the immunosuppressive TME in LCT-MF.
exosome	34831007	hsa-mir-1227	Prostatic Neoplasms	Here, we show that miR-1227, which is enriched in prostate cancer EVs, compared to the cell of origin, but not in EVs derived from prostate benign epithelial cells, induces the shedding of large EVs (such as large oncosomes), while inhibiting the shedding of small EVs (such as exosomes).
other	34830882	hsa-mir-486	Breast Neoplasms	Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers' cross-sectional area and muscle dysfunction, that were not preserved by AET.
other	34830882	hsa-mir-486	Colonic Neoplasms	Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers' cross-sectional area and muscle dysfunction, that were not preserved by AET.
genetics_knock down_promote	34830864	hsa-mir-125b	Colorectal Neoplasms	Overexpression of miR-125b in CRC cells enhanced migration capacity, while knockdown of miR-125b decreased migration and invasion.
circRNA target	34830863	hsa-mir-1178	Squamous Cell Carcinoma of Head and Neck	Furthermore, circRNA-102450 directly bound to, and consequently down-regulated, miR-1178 in OSCC cells. Taken together, circRNA-102450 has a tumor suppressive effect via the circRNA-102450/miR-1178 axis and may be a novel potential marker of RLNM in OSCC patients.
transcription factor target	34830317	hsa-mir-26a-2	Myositis	IPA also effectively protected against LPS-induced C2C12 cells inflammation by activating Pregnane X Receptor and restoring the inhibited miR-26a
circulation_biomarker_diagnosis_ns	34830203	hsa-mir-23a	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
circulation_biomarker_diagnosis_ns	34830203	hsa-let-7a	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
circulation_biomarker_diagnosis_ns	34830203	hsa-let-7d	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
circulation_biomarker_diagnosis_ns	34830203	hsa-mir-874	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
circulation_biomarker_diagnosis_ns	34830203	hsa-mir-361	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
circulation_biomarker_diagnosis_ns	34830203	hsa-mir-27b	Macular Degeneration	5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls.
other	34830196	hsa-mir-16	Prostatic Neoplasms	miR-195/miR-16 were negatively associated with PD-L1 expression and positively correlated to longer biochemical recurrence-free survival; they also enhanced the radiotherapy efficacy in PC cell lines.
other	34830196	hsa-mir-195	Prostatic Neoplasms	miR-195/miR-16 were negatively associated with PD-L1 expression and positively correlated to longer biochemical recurrence-free survival; they also enhanced the radiotherapy efficacy in PC cell lines.
other	34830057	hsa-mir-146a	Arthritis, Rheumatoid	Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA.
transcription factor target	34830057	hsa-mir-34a	Arthritis, Rheumatoid	In a murine model, miR-34a inhibition can ameliorate the arthritis score.
genetics_GWAS	34830054	hsa-mir-223	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Here, we examine the genetic structure and biological roles of CLEC12A-MIR223HG, a novel chimeric transcript produced by the fusion of the cell surface receptor CLEC12A and the miRNA-223 host gene (MIR223HG), first identified in chronic myeloid leukemia (CML) patients. Surprisingly, we observed that CLEC12A-MIR223HG is not just expressed in CML, but also in a variety of normal tissues and cell lines.
other	34829725	hsa-mir-92b	Depression	Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression.
other	34829725	hsa-mir-92b	Sleep Apnea, Obstructive	Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression.
other	34829725	hsa-mir-15b	Sleep Apnea, Obstructive	Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression.
other	34829725	hsa-mir-15b	Depression	Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression.
other	34828420	hsa-mir-6888	Non-alcoholic Fatty Liver Disease	We have selected EDN1/TNF/MAPK3/EP300/hsa-miR5p/lncRNA RABGAP1L-DT-206 RNA panel from bioinformatics microarrays databases related to STING pathway and NAFLD/NASH pathogenesis.
other	34828420	hsa-mir-6888	Carcinoma, Hepatocellular	We have selected EDN1/TNF/MAPK3/EP300/hsa-miR5p/lncRNA RABGAP1L-DT-206 RNA panel from bioinformatics microarrays databases related to STING pathway and NAFLD/NASH pathogenesis.
other	34828332	hsa-mir-629	Prostatic Neoplasms	5p, and let-7d-5p.
other	34828332	hsa-mir-194	Prostatic Neoplasms	5p, and let-7d-5p.
other	34828332	hsa-let-7d	Prostatic Neoplasms	5p, and let-7d-5p.
circulation_biomarker_diagnosis_up	34828307	hsa-mir-1206	Pancreatic Carcinoma	Cytoplasmic circ_0092367 could directly repress the levels of miR-1206 and thus upregulate the expression of ESRP1, thereby inhibiting EMT and enhancing the sensitivity of PC cells to gemcitabine treatment.
other	34828282	hsa-mir-137	Breast Neoplasms	Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/mi might be partially responsible for MUC14's functions in breast cancer.
lncRNA target	34828265	hsa-mir-92a	Cholangiocarcinoma	To elucidate the detailed regulatory mechanism, miR-92a-3p is screened and identified as a negative regulatory small RNA targeting NOV, and further experimental validation demonstrates that miR-92a-3p contributes to NOV-mediated migration and invasion of ICC via the Notch signaling pathway.
circulation_biomarker_diagnosis_ns	34827715	hsa-mir-4454	Cardiomyopathy, Hypertrophic	3p and miR-4454 levels are elevated in the plasma of HCM patients.
other	34827683	hsa-mir-629	Coronary Artery Disease	5p were significantly correlated with acute myocardial infarction.
other	34827683	hsa-mir-98	Coronary Artery Disease	5p were significantly correlated with acute myocardial infarction.
other	34827683	hsa-mir-5701	Coronary Artery Disease	Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes.
other	34827618	hsa-mir-6300	Fusariosis	These results imply that miR319a-JRL3, miR6300-BEE1, miR6300-DAHP1 and miR6300-PERK2 regulate cucumber defenses against FW, and provide the gene resources that may be useful for breeding programs focused on developing new cucumber varieties with enhanced resistance to FW.
other	34827618	hsa-mir-19a	Fusariosis	These results imply that miR319a-JRL3, miR6300-BEE1, miR6300-DAHP1 and miR6300-PERK2 regulate cucumber defenses against FW, and provide the gene resources that may be useful for breeding programs focused on developing new cucumber varieties with enhanced resistance to FW.
other	34827608	hsa-mir-191	Aortic Aneurysm, Abdominal	Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms.
lncRNA target	34826437	hsa-mir-17	Carcinoma, Hepatocellular	hA-MSCs modulation may be partially achieved via dysregulation of intracellular miR17-5P and 615-5p expression, suggesting an important role for miRNAs in HCC pathogenesis, and as a possible therapeutic candidate.
circulation_biomarker_diagnosis_up	34826094	hsa-mir-27	Gastroenteritis, Transmissible, of Swine	Here, we demonstrated that microRNA-27b-3p (miR-27b-3p) suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6 (SOCS6), while TGEV infection downregulated miR-27b-3p expression in swine testicular (ST) cells and in piglets. Mechanistically, the decrease of miR-27b-3p expression during TGEV infection was mediated by the activated inositol-requiring enzyme 1 (IRE1) pathway of the endoplasmic reticulum (ER) stress.
circulation_biomarker_diagnosis_up	34826094	hsa-mir-27b	Gastroenteritis, Transmissible, of Swine	Here, we demonstrated that microRNA-27b-3p (miR-27b-3p) suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6 (SOCS6), while TGEV infection downregulated miR-27b-3p expression in swine testicular (ST) cells and in piglets. Mechanistically, the decrease of miR-27b-3p expression during TGEV infection was mediated by the activated inositol-requiring enzyme 1 (IRE1) pathway of the endoplasmic reticulum (ER) stress.
lncRNA target	34826047	hsa-mir-101a	Parkinson Disease	Our findings demonstrated that lncRNA Riken alleviated the sevoflurane-induced neurotoxic effects, and the lncRNA Riken/miR-101a/MKP-1/JNK axis plays an important role in the cognitive disorder.
genetics_knock down_promote	34826027	hsa-mir-196a	Esophageal Squamous Cell Carcinoma	Next, functional experiments showed that knockdown of miR-196a or UHRF2 overexpression suppress EC cell proliferation and migration.
genetics_knock down_promote	34825699	hsa-mir-582	Leukemia, Myeloid, Acute	CONCLUSION: Knockdown of circ-SFMBT2 suppressed AML progression by regulating the miR
circRNA target	34825467	hsa-mir-636	Uterine Cervical Neoplasms	circ_0023404 silencing could attenuate the progression of cervical cancer cells partly by targeting the miR-636/CYP2S1 axis, hinting at a promising therapeutic target for cervical cancer.
other	34825289	hsa-mir-130a	Carcinoma, Hepatocellular	Here, we found that TFB1M was significantly upregulated in HCC cells probably due to decreased miR-130a-3p expression.
lncRNA target	34825062	hsa-mir-22	Breast Neoplasms	We suggest that LIG1 and LIG3 are novel valuable prognostic biomarkers for BC and has-miRNA3p may be a potential therapeutic target for BC.
other	34825000	hsa-mir-199a	Cholesteatoma	RESULTS: The upregulation of miR-199a was found in cholesteatoma tissues, which facilitated the proliferation, migration, and invasion of HaCaT cells, while its downregulation caused opposite results.
transcription factor target	34824671	hsa-mir-34a	Reperfusion Injury, Cerebral Ischemia	Mechanistically, neuronal USP29 enhanced p53/miR-34a-mediated silent information regulator 1 downregulation and then promoted the acetylation and suppression of brain and muscle ARNT-like protein, thereby aggravating oxidative stress and apoptosis upon cerebral I/R injury.
genetics_GWAS	34824636	hsa-mir-148	Glioma	The objective of the present study was to measure microRNA-3148 (miR-3148) expression and investigate its impact on the pathogenetic mechanism of glioma.
other	34824551	hsa-mir-105	Colorectal Neoplasms	lncRNA MCF2L-AS1/miR-105/ IL-1β Axis Regulates Colorectal Cancer Cell Oxaliplatin Resistance.
other	34824224	hsa-mir-122	Hepatitis C	For hepatitis C virus (HCV), binding of liver-abundant miR-122 stabilizes the viral RNA and regulates viral translation.
genetics_overexpression_promote	34824176	hsa-mir-155	Uterine Cervical Neoplasms	CONCLUSION: Conclusions: These data suggest that overexpression of miRNA-155 can delineate cervical cancer tissues from normal and may be a useful diagnostic biomarker for early detection of cervical cancer.
circulation_biomarker_diagnosis_ns	34823560	hsa-mir-146a	Diabetes Mellitus	We investigated if serum miR-146a-5p levels were independently associated with micro/macrovascular complications of type 1 diabetes (DM1). CONCLUSIONS: In this large cohort of DM1 patients, we reported an inverse and independent association of miR-146a-5p with diabetes chronic complications and in particular with CVD and retinopathy, suggesting that miR-146a-5p may be a novel candidate biomarker of DM1 complications.
circulation_biomarker_diagnosis_ns	34823560	hsa-mir-146a	Diabetes Complications	We investigated if serum miR-146a-5p levels were independently associated with micro/macrovascular complications of type 1 diabetes (DM1). CONCLUSIONS: In this large cohort of DM1 patients, we reported an inverse and independent association of miR-146a-5p with diabetes chronic complications and in particular with CVD and retinopathy, suggesting that miR-146a-5p may be a novel candidate biomarker of DM1 complications.
genetics_overexpression_suppress	34823537	hsa-mir-375	Esophageal Squamous Cell Carcinoma	miR-375 was found to be significantly down-regulated in esophageal squamous cell carcinoma (ESCC) tissues and its overexpression effectively inhibits the proliferation, migration, and invasion of ESCC cells.
other	34823423	hsa-mir-148b	Stomach Neoplasms	The expression of miR-148b-3p was negatively correlated with that of UBAP2L in gastric cancer samples.
exosome	34823099	hsa-mir-455	Spinal Cord Ischemia	In summary, exosomes containing miR
lncRNA target	34822025	hsa-mir-665	Colorectal Neoplasms	Diaphanous Homolog 1 level was regulated by circ_0044556 via sponging miR-665 in CRC cells.
genetics_knock down_promote	34821374	hsa-mir-577	Pancreatic Carcinoma	By contrast, miR577 was significantly inhibited in pancreatic cancer cells and tissues; its downregulation promoted pancreatic cancer cell proliferation, migration and invasion, and reversed the effects of FGD5AS1 knockdown on pancreatic cancer cells. In conclusion, in pancreatic cancer, highly expressed FGD5AS1 activated the Wnt/betacatenin signaling and promoted cancer cell proliferation, migration and invasion via suppression of miR577.
genetics_knock down_promote	34821362	hsa-mir-1297	Stomach Neoplasms	In a word, lncRNA SNHG6 knockdown had inhibitory effects on DDP resistance and progression of GC by sponging miR-1297, highlighting its potential in GC treatment.
other	34821091	hsa-mir-155	Hyperglycinemia, Nonketotic	3p can promote EAF1 mRNA degradation and proliferation in HANK1 cells.
lncRNA target	34821009	hsa-mir-205	Esophageal Neoplasms	Altogether, we highlight that the miR205HG-HNRNPA0 axis is implicated in the migration and invasion of ESCA cells and that these members of this pathway may serve as therapeutic targets to inhibit metastasis of ESCA.
other	34821000	hsa-mir-181a	Prostatic Neoplasms	We observe that miR-181a is highly expressed in patients with prostate cancer and that this pattern associates with lower expression of NKG2D, a critical mediator of cancer surveillance.
lncRNA target	34820432	hsa-mir-146a	Atherosclerosis	lncRNA H19 promoted the expression of ANGPTL4 via competitively binding to miR-146a-5p, thus promoting lipid accumulation in atherosclerosis. These findings altogether demonstrated that lncRNA H19 facilitated the accumulation of lipid in macrophages and aggravated the progression of atherosclerosis through the miR-146a-5p/ANGPTL4 pathway.
lncRNA target	34820156	hsa-mir-4268	Aortic Aneurysm, Abdominal	CONCLUSIONS: Overall, our data suggest that circRBM33 might be involved in AAA progression by regulating ECM degradation via the miR-4268/EPHB2 axis.
lncRNA target	34820151	hsa-mir-99a	Encephalomyelitis, Autoimmune, Experimental	MicroRNA-99a (miR-99a) has been shown to be involved in adipose tissue inflammation and to be downregulated in the inflammatory lesions of autoimmune diseases rheumatoid arthritis and systemic lupus erythematosus. Taken together, our results characterize a pivotal role of miR-99a in regulating CD4(+) T cell differentiation and glycolysis reprogramming during EAE development, which may indicate that miR-99a is a promising therapeutic target for the amelioration of multiple sclerosis and possibly other autoimmune diseases.
transcription factor target	34820014	hsa-mir-337	Breast Neoplasms	3p targeted CDK1 to inhibit BC cell progression.
circulation_biomarker_prognosis_up	34820011	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	Previous studies have reported the diagnostic and prognostic value of serum microRNA (miR)-145 and vascular endothelial growth factor (VEGF) levels in various types of cancer; however, their clinical use in non-small cell lung cancer (NSCLC) remains unclear.
target gene	34820010	hsa-mir-152	Carcinoma, Non-Small-Cell Lung	DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway.
circulation_biomarker_diagnosis_down	34819824	hsa-mir-126	Coronary Artery Disease	CONCLUSION: The results of our study show the potential of circulating miR-126 as a novel non-invasive biomarker in the risk prediction of CAD.
circulation_biomarker_diagnosis_down	34819824	hsa-mir-122	Coronary Artery Disease	CONCLUSION: The results of our study show the potential of circulating miR-126 as a novel non-invasive biomarker in the risk prediction of CAD.
transcription factor target	34819106	hsa-mir-6791	Adenocarcinoma of Lung	Finally, through analysis of ENST00000609697 target genes, we identified the ENST00000609697-hsa-miR5p-RASL12 ceRNA network, which may play a tumor-suppressive role in LUAD.
lncRNA target	34818977	hsa-mir-874	Osteoporosis	In conclusion, miR3p promoted the proliferation and differentiation of hBMSCs by downregulating the expression of LEP, thus inhibiting OP.Abbreviations : miRNAs: microRNAs; OP: osteoporosis; hBMSCs: human Bone Marrow Mesenchymal stem cells; LEP: leptin; DEGs: differentially expressed genes.
lncRNA target	34818974	hsa-mir-140	Adenocarcinoma of Lung	3p inhibited the proliferation, migration, invasion and angiogenesis of LUAD cells via targeting TYMS.
lncRNA target	34818961	hsa-mir-492	Carcinoma, Non-Small-Cell Lung	Silencing of miR-492 inhibited NSCLC cell proliferation, migration and invasion, and UTMD-mediated miR-492 inhibitor could promote more significant inhibition, which indicated that UTMD-mediated miR-492 inhibitor might provide a novel strategy for the treatment of NSCLC.KEY MESSAGESmiR-492 inhibitor inhibited cell proliferation, migration and invasion.UTMD-mediated miR-492 inhibitor can promote more significant inhibition.UTMD-mediated miR-492 inhibitor provide a new strategy for NSCLC.
other	34818876	hsa-mir-21	Pre-Eclampsia	miR-21 was upregulated in the tissues from PE women, whereas MEG3 was downregulated, and the two were negatively correlated. Collectively, this study demonstrates that the lncRNA MEG3 acts as a sponge for miR-21, which regulates BMPR2 expression and promotes trophoblast cell proliferation and invasiveness, thereby preventing the development of PE.
genetics_knock down_suppress	34818544	hsa-mir-135b	Breast Neoplasms	In TNBCs, FBXL16 expression is downregulated by the p38/miR-135b-3p axis, and loss of FBXL16 expression restores HIF1alpha-mediated metastatic features of breast cancer.
other	34818353	hsa-mir-181d	esophagus adenocarcinoma	The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC.
other	34818353	hsa-mir-185	esophagus adenocarcinoma	The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC.
other	34818353	hsa-mir-15b	esophagus adenocarcinoma	The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC.
other	34818353	hsa-mir-214	esophagus adenocarcinoma	The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC.
other	34818353	hsa-mir-496	esophagus adenocarcinoma	The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC.
genetics_overexpression_suppress	34818258	hsa-mir-138	Carcinoma, Ovarian Epithelial	5p-overexpressing ovarian cancer cells successfully recovered the Taxol resistance.
genetics_overexpression_promote	34818249	hsa-mir-196a	Acute Kidney Injury	lncRNA-H19 overexpression promotes kidney fibrosis and activates fibroblasts during AKI-CKD development, while miR-196a-5p overexpression reversed these effects in vitro. CONCLUSION: lncRNA-H19 induces kidney fibrosis during AKI-CKD by regulating the miR-196a-5p/Wnt/beta-catenin signaling pathway.
genetics_knock down_promote	34818025	hsa-mir-375	Carcinoma, Hepatocellular	Replenishing of miR-375 or knockout of NCAPG2 could be therapeutically exploited for HCC.
lncRNA target	34817912	hsa-mir-876	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: CircCDR1as acted as an oncogene in OSCC progression through elevating SLC7A11 by targeting miR
genetics_overexpression_promote	34817752	hsa-mir-1277	Glioma	5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR
other	34817483	hsa-mir-214	Aortic Valve Disease	Release of AuNP/miRNAs is quantified, AuNP-miR-214 functionality is shown in vitro in HEK293 cells, and AuNP-miRNAs are tracked in a 3D bioprinted human model of calcific aortic valve disease (CAVD).
circulation_biomarker_diagnosis_ns	34817483	hsa-mir-214	autosomal recessive congenital bilateral absence of vas deferens	Release of AuNP/miRNAs is quantified, AuNP-miR-214 functionality is shown in vitro in HEK293 cells, and AuNP-miRNAs are tracked in a 3D bioprinted human model of calcific aortic valve disease (CAVD). In the CAVD model, AuNP-miR-214 are tracked into the cytoplasm of human aortic valve interstitial cells.
lncRNA target	34817330	hsa-mir-34c	Nasopharyngeal Carcinoma	3p and miR-34c in nasopharyngeal carcinoma tissues and evaluate its clinical value as a molecular marker for predicting the prognosis in patients with nasopharyngeal carcinoma through clinical case study.
lncRNA target	34816790	hsa-mir-101	cervical squamous cell carcinoma	3p suppressed cervical squamous cell carcinoma cell growth by targeting KPNA2.
lncRNA target	34816661	hsa-mir-670	Lung Neoplasms	5p promotes proliferation, migration and invasion of lung cancer cells by targeting WWOX.
transcription factor target	34816499	hsa-mir-195	Sepsis	5p could relieve sepsis-induced MI by targeting ATF6.
transcription factor target	34816499	hsa-mir-195	Cardiomyopathies	5p could relieve sepsis-induced MI by targeting ATF6.
genetics_knock down_promote	34815768	hsa-mir-25	Glioma	The knockdown of miR-25 expression significantly reduced glioma cell proliferation, migration and invasion.
target gene	34815714	hsa-mir-181a	Stomach Neoplasms	Targeting Oncogenic miR-181a-2-3p Inhibits Growth and Suppresses Cisplatin Resistance of Gastric Cancer.
lncRNA target	34815712	hsa-mir-27b	Carcinoma, Hepatocellular	CONCLUSION: DNAJC3-AS1 promotes HCC by sponging premature miR-27b and might be a biomarker and therapeutic target for HCC.
other	34815668	hsa-mir-452	Emphysema	miR-452, miR-149, miR-133a, miR-181a and miR-421 in hub microRNAs may play a role in COPD.
other	34815668	hsa-mir-452	Pulmonary Disease, Chronic Obstructive	miR-452, miR-149, miR-133a, miR-181a and miR-421 in hub microRNAs may play a role in COPD.
transcription factor target	34815662	hsa-mir-342	Colonic Neoplasms	Objective To explore whether metformin (MET) can affect the biological behaviour and CD133 mRNA expression of CD133+ colon cancer stem cells (CCSCs) through miR
circulation_biomarker_prognosis_ns	34815474	hsa-mir-146a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Expression of plasma miR-146a may be utilized as non-invasive marker to diagnose and predict prognosis in pediatric and adult patients with ALL.
other	34815425	hsa-mir-1	Pulmonary Disease, Chronic Obstructive	The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD.
other	34815425	hsa-mir-155	Pulmonary Disease, Chronic Obstructive	The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD.
other	34815425	hsa-mir-106b	Pulmonary Disease, Chronic Obstructive	The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD.
genetics_overexpression_promote	34814928	hsa-mir-194	Polycystic Ovary Syndrome	METHODS: To clarify the effect of miR-194 in PCOS, CCK-8, Ki67 staining, AO/EB, and flow cytometry assays were used to assess cell growth, proliferation, and apoptosis in KGN cells, which were artificially stimulated to overexpress miR-194.
other	34814394	hsa-mir-483	Non-alcoholic Fatty Liver Disease	3p expression was higher in the NAFLD group (S1 or S2-3) than the control group.
other	34814394	hsa-mir-122	Non-alcoholic Fatty Liver Disease	3p expression was higher in the NAFLD group (S1 or S2-3) than the control group.
other	34814394	hsa-mir-197	Non-alcoholic Fatty Liver Disease	3p expression was higher in the NAFLD group (S1 or S2-3) than the control group.
other	34814394	hsa-mir-146b	Non-alcoholic Fatty Liver Disease	3p expression was higher in the NAFLD group (S1 or S2-3) than the control group.
exosome	34814060	hsa-mir-92a	Colorectal Neoplasms	The detection performance of the PEC biosensor has been tested using colorectal cancer-related exosomal miRNA (miR-92a-3p) as the target.
genetics_knock down_promote	34813772	hsa-mir-375	Glioma	Moreover, miR-375 inhibition reverted the anticancer effects of circ-CREBBP knockdown on glioma cells.
circulation_biomarker_diagnosis_ns	34812475	hsa-mir-155	Cardiomegaly	Circulating miR155 levels are related to chronic heart failure (CHF). Schisandrin A mediated the AKT/CREB signaling pathway to prevent CHF by regulating the expression of miR155, which may shed light on a possible therapeutic target for CHF.
other	34812409	hsa-mir-335	Parkinson Disease	CONCLUSION: miR5p has low expression in PD and is expected to be a potential diagnostic indicator.
circulation_biomarker_diagnosis_ns	34812409	hsa-mir-374a	Parkinson Disease	The miR-374a-5p expression in the serum of the RG was reduced markedly and had a diagnostic value.
lncRNA target	34812269	hsa-mir-15a	Carcinoma, Hepatocellular	Our investigation is aimed at testifying the influence of microRNA-15a-5p (miR-15a-5p)/eukaryotic translation initiation factor 4E (eIF4E) on hepatocellular carcinoma resistance to pirarubicin (THP). These findings supported that miR-15a-5p facilitated THP resistance of hepatocellular carcinoma cells by modulating eIF4E, thus providing an experimental basis that miR-15a-5p might act as a novel diagnostic target in hepatocellular carcinoma resistance to THP.
genetics_overexpression_promote	34811815	hsa-mir-924	Carcinoma, Non-Small-Cell Lung	miR-924 interacted with the 3' untranslated region (3'UTR) of SLC1A5, and SLC1A5 overexpression largely overturned miR-924 overexpression-mediated anti-tumor effects in NSCLC cells.
genetics_GWAS	34811809	hsa-mir-148a	Gastric Cancer, Early	METHODS We compared the accuracy of physician-performed endoscopy (trainee, n = 3; specialists, n = 3), artificial intelligence (AI)-based endoscopy, and/or molecular markers (DNA methylation: BARHL2, MINT31, TET1, miR-148a, miR-124a-3, NKX6-1; mutations: TP53; and microsatellite instability) in diagnosing GIN lesions. CONCLUSION AI with miR148s DNA methylation-based diagnosis is a potential modality for diagnosing GIN.
circulation_biomarker_diagnosis_ns	34811713	hsa-mir-574	Schizophrenia	5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients.
circulation_biomarker_diagnosis_ns	34811713	hsa-mir-1827	Schizophrenia	5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients.
circulation_biomarker_diagnosis_ns	34811713	hsa-mir-4429	Schizophrenia	5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients.
exosome	34811696	hsa-mir-128	Carcinoma, Pancreatic Ductal	The effect of exosomes rich in hsa-miRNA
lncRNA target	34811354	hsa-mir-150	Thyroid Neoplasms	Our findings suggest MIAT may inhibit EZH2 expression and promote PTC cell invasion via the miR-150/EZH2 pathway.
circRNA target	34811353	hsa-mir-200b	Urinary Bladder Neoplasms	Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.
target gene	34810290	hsa-mir-21	Stomach Neoplasms	Xiaotan Sanjie decoction decoction can inhibit the multiplicative effect of GCIF on gastric cancer cells, growth of gastric tumor and promotion effect of GCIF on tumors, probably due to the down-regulating miR-21 expression in tumor tissues.
other	34809740	hsa-mir-494	Diabetes, Gestational	Objective To investigate the relation between the miR-494 expression with pancreatic islets beta cell function and gestational diabetes mellitus.
other	34809738	hsa-mir-136	Leukemia, Myeloid, Acute	Methods The expression level of CRNDE in bone marrow cells of AML patients was analyzed by GEPIA database; the mRNA expression levels of miR5p, CRNDE, and minichromosome maintenance 5(MCM5) in AML cell lines were detected by quantitative real-time PCR (qRT-PCR).
circulation_biomarker_diagnosis_ns	34808619	hsa-mir-29b	Multiple Sclerosis	BACKGROUND: We aimed to evaluate the therapeutic effects of interferon-beta (IFN-beta) on hsa-miR29b-3p and hsa-miR326 in isolated T-helper (Th)1 and Th17 cells expressed by relapsing-remitting multiple sclerosis (RRMS) patients before and after 1 year of treatment with IFN-beta. RESULTS: Th17 cells and plasma levels of IL-17A decreased in RRMS patients after IFN-beta therapy but hsa-miR-29b-3p and hsa-miR-326 expression had no significant change in treated RRMS patients versus baseline.
circulation_biomarker_diagnosis_ns	34808619	hsa-mir-326	Multiple Sclerosis	BACKGROUND: We aimed to evaluate the therapeutic effects of interferon-beta (IFN-beta) on hsa-miR29b-3p and hsa-miR326 in isolated T-helper (Th)1 and Th17 cells expressed by relapsing-remitting multiple sclerosis (RRMS) patients before and after 1 year of treatment with IFN-beta. RESULTS: Th17 cells and plasma levels of IL-17A decreased in RRMS patients after IFN-beta therapy but hsa-miR-29b-3p and hsa-miR-326 expression had no significant change in treated RRMS patients versus baseline.
circulation_biomarker_diagnosis_up	34808575	hsa-mir-18a	Tuberculosis	RESULTS: The expression of GAS5 in TB patients was down-regulated, while miR-18a-5p was up-regulated, and the serum inflammatory factors were negatively correlated with the expression level of GAS5. CONCLUSION: This study indicated that the expression level of GAS5 in the serum of TB patients was decreased, while in the cells infected with MTB, the down-regulated GAS5 might develop a role in facilitating the cell vitality and the inflammatory response by adsorbing miR-18a-5p in the form of molecular sponge.
lncRNA target	34808501	hsa-mir-499a	Uterine Cervical Neoplasms	Inhibition of DGUOK-AS1, miR-499a-5p, and SPRR1B was applied for exploring the biological function based on detection of cell viability, proliferation, migration, and apoptosis in CESC SiHa and HeLa cells.
transcription factor target	34808462	hsa-mir-376a	Glioma	miR-376a mimic inhibited SIRT1, YAP1, and VEGF expression and suppressed the proliferation, migration and angiogenesis abilities of the glioma cell lines LN229 and A172, whereas miR-376a inhibitor exerted the opposite functions.
transcription factor target	34808462	hsa-mir-376	Glioma	miR-376a mimic inhibited SIRT1, YAP1, and VEGF expression and suppressed the proliferation, migration and angiogenesis abilities of the glioma cell lines LN229 and A172, whereas miR-376a inhibitor exerted the opposite functions.
lncRNA target	34808429	hsa-mir-195	Liver Neoplasms	Propofol inhibited the viability of liver cancer cells and stimulated the up-regulation of miR
genetics_knock down_suppress	34808393	hsa-mir-139	Non-alcoholic Fatty Liver Disease	NEAT1 knockdown restrained lipid accumulation in the NAFLD cellular model by directly targeting miR
other	34808225	hsa-mir-101	Osteosarcoma	3p.
other	34808131	hsa-mir-1908	Arthritis, Rheumatoid	In summary, our study suggests that HOTTIP plays a damaging role in RA by promoting inflammation, which may be related to the regulation of miR5p expression and the STAT3 signaling pathway.
genetics_GWAS	34807526	hsa-mir-19a	Leukemia, Myeloid	In summary, leukemic cell-derived sEV-related miR-19a-3p confers immunosuppression to CD8+ T cells by targeting SLC6A8-mediated creatine import, indicating that sEV-related miR-19a-3p might be a promising therapeutic target for NPM1-mutated AML.
lncRNA target	34807376	hsa-let-7b	Carcinoma, Hepatocellular	The current study investigates the inhibitory effect of let-7b miRNA on HCV replication in the Hepatocarcinoma cell line (Huh7.5).
lncRNA target	34807376	hsa-let-7b	Hepatitis C	The current study investigates the inhibitory effect of let-7b miRNA on HCV replication in the Hepatocarcinoma cell line (Huh7.5).
genetics_GWAS	34806925	hsa-mir-381	Breast Neoplasms	More importantly, rescue experiments demonstrated that miR-381 inhibition could inverse the tumor-suppressive effect of SNHG1 silencing in breast cancer. In summary, SNHG1 silencing suppressed tumor progression and overcame breast cancer cell DDP resistance via the epigenetic suppression of miR-381 expression.
other	34806869	hsa-mir-200b	Prostatic Neoplasms	Using this assay, with a limit-of-detection of 122 aM, we successfully analyzed vesicular miRNA 200b from prostate cancer cell lines and human urine samples, demonstrating the expected lower expression levels of miRNA 200b in the EVs from prostate cancer cells and in the prostate cancer patient's urine samples compared to healthy patients and non-tumorigenic cell lines, validating the suitability of our approach for clinical analysis.
other	34806748	hsa-mir-495	Carcinoma, Hepatocellular	3p and miR-1293 were differentially expressed in HCC patients, and may be involved in the pathophysiology of HCC.
other	34806748	hsa-mir-1293	Carcinoma, Hepatocellular	3p and miR-1293 were differentially expressed in HCC patients, and may be involved in the pathophysiology of HCC.
transcription factor target	34806650	hsa-mir-124	Arthritis, Rheumatoid	3p could specifically promote Th17 cell pathogenicity in part through interaction with T-bet, and these findings present promising therapeutic targets in RA.
genetics_overexpression_promote	34806436	hsa-mir-340	Incisional Pain	5p or overexpression of RAB1A partly reversed the effect of sh-XIST on PIP rats.
circulation_biomarker_prognosis_ns	34806417	hsa-mir-27b	Carotid Stenosis	The present results provide evidence for circulating miR-27b as a diagnostic and prognostic marker in patients with ACAS.
exosome	34806156	hsa-mir-15b	Diabetic Nephropathies	In the current study, we determined the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing microRNA (miR)-15b-5p in DN.
genetics_knock down_promote	34805531	hsa-mir-654	Stomach Neoplasms	5p knockdown on GC cell malignant behaviors.
transcription factor target	34805092	hsa-mir-141	Prostatic Neoplasms	Here we chose miRNA141-a potentially diagnostic biomarker of prostate cancer as the model target.
genetics_GWAS	34804964	hsa-mir-146a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children.
other	34804964	hsa-mir-499a	Leukemia	Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia.
genetics_GWAS	34804964	hsa-mir-146a	Leukemia	Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children.
genetics_GWAS	34804964	hsa-mir-196a-2	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children.
genetics_GWAS	34804964	hsa-mir-196a-2	Leukemia	Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children.
other	34804964	hsa-mir-612	Leukemia	Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia.
other	34804964	hsa-mir-499a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia.
other	34804964	hsa-mir-612	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia.
genetics_GWAS	34804952	hsa-mir-499a	Endometrial Neoplasms	By combining miR-499a-3p or -5p expression levels with the CTNNB1 status, ECs with CTNNB1 mutation and lower miR-499a-5p expression showed better OS compared with the other subgroups (p = 0.03, log-rank test), among the NSMP patients.
other	34804934	hsa-mir-21	Neuroblastoma	responsive gene reporter may be a potential method for visualization of the endogenous miR-21 activity in neuroblastoma and its response to gene therapy.
target gene	34804881	hsa-mir-186	Thyroid Cancer, Papillary	Long noncoding RNA SNHG6 promotes papillary thyroid cancer cells proliferation via regulating miR-186/CDK6 axis.
other	34804856	hsa-mir-26a	Fanconi Anemia	The relationship between NEAT1 or fanconi anemia (FA) complementation group E (FANCE) and miR-26a-5p was verified by dual-luciferase reporter assay.
transcription factor target	34804823	hsa-mir-200c	Carcinoma, Renal Cell	CONCLUSIONS: Our results revealed that downregulation of QKI-5 by miR-200c attenuated KIRC migration and invasion via the EMT process, indicating that QKI-5 may be a potential therapeutic target and a key indicator of KIRC progression.
other	34804425	hsa-mir-146a	Diabetic Retinopathy	CONCLUSION: It can be concluded that miR-146a-5p may regulate Nrf2 and NF-kappaB expression and inflammation and oxidative stress in the ocular tissue of diabetic rats.
other	34804425	hsa-mir-146a	Diabetes Mellitus, Type 2	CONCLUSION: It can be concluded that miR-146a-5p may regulate Nrf2 and NF-kappaB expression and inflammation and oxidative stress in the ocular tissue of diabetic rats.
target gene	34804161	hsa-mir-186	Adenocarcinoma of Lung	MiR-186 Suppressed Growth, Migration, and Invasion of Lung Adenocarcinoma Cells via Targeting Dicer1.
circulation_biomarker_diagnosis_up	34804121	hsa-mir-650	Crohn Disease	Here, quantitative reverse transcription PCR (RT-QPCR) results revealed that upregulated hsa_circRNA_103124 expression in patients with CD was negatively correlated with hsa-miR-650 expression but positively correlated with the white blood cell count and calprotectin levels. These results indicate that hsa_circRNA_103124 upregulation in patients with CD promotes cell proliferation and inhibits autophagy by regulating the hsa-miR-650/AKT2 signaling pathway.
circulation_biomarker_diagnosis_ns	34804062	hsa-mir-1	Acquired Immunodeficiency Syndrome	Here, focusing on a unique cohort of HIV-infected former blood donors, we identified miR-31 (hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease progression. Our results implicated miR-31 as a useful biomarker for tracking HIV disease progression and, by demonstrating its importance in tuning the activation of CD4+ T cells, suggested that miR-31 may play critical roles in other physiological contexts where the CD4+ T cell homeostasis needs to be deliberately controlled.
exosome	34804057	hsa-mir-21	Hyperaldosteronism	Association of AGP1 with aldosterone, renin activity, and ARR, besides the high discriminatory capacity of AGP1 and uEV-miR5p to identify the PA condition, place both as potential biomarkers of PA.
other	34804048	hsa-let-7e	Tuberculosis, Multidrug-Resistant	The miR-let7e-5p is a candidate biomarker for long-term monitoring of treatment for the group of MDR-TB without T2DM.
transcription factor target	34803501	hsa-mir-34a	Squamous Cell Carcinoma of Head and Neck	Overall, these results suggest that miR-34a-5p can function as a tumor suppressor miRNA in HNSCC owing to its ability to target FLOT-2, highlighting the promise of targeting this regulatory axis to treat HNSCC.
lncRNA target	34803496	hsa-mir-196a	Carcinoma, Renal Cell	MiR-196a promotes renal cancer cell migration by directly targeting Bram1 and inhibits Smad1/5/8 phosphorylation and MAPK pathways through BMPR1A and EGFR.
other	34803495	hsa-mir-24-2	Retrognathia	Conclusions: In this study, we investigated the regulatory mechanism of Mir245p on Gnai3 expression regulation in osteoblast precursor cells and provided a new idea of improving the prevention and treatment strategies for congenital mandibular defects and mandibular protrusion.
circulation_biomarker_diagnosis_down	34803495	hsa-mir-24-2	Mandibular Diseases	5p was significantly downregulated in the serum of young people with overgrowing mandibular, and bioinformatics analysis suggested possible binding sites of Mir24
other	34803495	hsa-mir-24-2	Bone Diseases	Therefore, this study was designed to investigate the mechanism of Mir245p-mediated regulation of Gnai3 gene expression and explore the possibility of potential treatment strategies for bone defects.
other	34803495	hsa-mir-24-2	Temporomandibular Joint Dysfunction Syndrome	Conclusions: In this study, we investigated the regulatory mechanism of Mir245p on Gnai3 expression regulation in osteoblast precursor cells and provided a new idea of improving the prevention and treatment strategies for congenital mandibular defects and mandibular protrusion.
other	34803458	hsa-mir-125b	Breast Neoplasms	Upregulation of miR-125b may be used as a biomarker for the prediction of response to paclitaxel treatment in breast cancer.
lncRNA target	34803403	hsa-mir-552	Esophageal Neoplasms	CONCLUSION: Altogether, our findings indicated that LINC00261 exerts a suppressive effect on EC radioresistance via the competing endogenous RNA network to sponge miR
lncRNA target	34803150	hsa-mir-423	Diabetic Nephropathies	5p/GLIPR2 axis might be a potential target for DN treatment.
lncRNA target	34803150	hsa-mir-423	Pulmonary Fibrosis	5p/GLIPR2 axis might be a potential target for DN treatment.
lncRNA target	34803150	hsa-mir-423	Inflammation	5p/GLIPR2 axis might be a potential target for DN treatment.
lncRNA target	34802869	hsa-mir-26b	Colorectal Neoplasms	Additional algorithms predicted a higher miR-26b level was associated with significantly higher survival in CRC patients and GSK3beta and CDK6 as targets of miR-26b-5p. CONCLUSIONS: Pharmacological intervention with gMG suppressed CRC carcinogenesis and stemness via downregulating GSK3/beta-catenin/CDK6 and upregulating the miR-26b-5p tumor suppressor.
transcription factor target	34802444	hsa-mir-612	Coronary Artery Disease	These findings suggest that hypoxic OM-MSC-EVs may represent a promising strategy for ischemic disease by promoting angiogenesis via miR-612 transfer.
other	34802430	hsa-mir-142	Ovarian Neoplasms	RESULTS: We showed that miR-25 and miR-142 were differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tumors.
genetics_knock down_promote	34802389	hsa-mir-3681	Glioblastoma	5p overexpression or MALT1 knockdown attenuated aggressiveness of GBM cells.
lncRNA target	34801999	hsa-mir-885	Uterine Cervical Neoplasms	5p in cervical cancer, and the possible targets, as well as the detailed mechanism of miR
other	34801860	hsa-mir-520h	Osteosarcoma	In this commentary, we have evaluated the work of Peng and colleagues on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma.
lncRNA target	34801689	hsa-mir-20a	Glycogen Storage Disease Type VI	Together, these results suggest that equol may have a dual effect on ER-positive cancer cells, acting with, antiproliferative activity through PAPD5 and exhibiting proliferative activity via ERalpha and the former could be associated with miR-320a.
exosome	34801597	hsa-mir-378a	Osteolysis	Our in vitro and in vivo functional and mechanistic assays revealed that EV-mediated release of miR-378a-3p from tumor cells was upregulated in bone-metastatic PCa, maintaining low intracellular miR-378a-3p concentration to promote proliferation and MAOA-mediated epithelial-to-mesenchymal transition.
lncRNA target	34801596	hsa-mir-409	Carcinoma, Non-Small-Cell Lung	Our results suggest that CBR3-AS1 functions as an oncogene through the CBR3-AS1/miR3p/SOD1 pathway, and may represent a new therapeutic target, especially to regulate radiosensitivity in NSCLC.
epigenetics	34801563	hsa-mir-432	Colorectal Neoplasms	CONCLUSION: This study showed that DNMT3B induced DNA methylation and downregulation of miR
lncRNA target	34801077	hsa-mir-377	Norrie disease	CONCLUSION: CircSMAD4 alleviates HG-induced SV40-MES13 cell inflammation, ECM deposition and apoptosis by relieving miR3p-mediated inhibition on BMP7 in DN progression.
lncRNA target	34800978	hsa-mir-455	Breast Neoplasms	CONCLUSION: Hsa_circ_0043278 acts as a tumour suppressor gene in BC through the hsa_circ_0043278/miR
transcription factor target	34800749	hsa-mir-144	Selenium Deficiency	In conclusion, Se deficiency can induce apoptosis and cell cycle arrest of bursa of Fabricius in Broilers by up regulating miR3p targeting STC1 and activating PI3K/AKT pathway, leading to injury of bursa of Fabricius in broilers.
other	34800440	hsa-mir-15b	Thyroid Cancer, Papillary	Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis.
other	34800440	hsa-let-7a	Thyroid Cancer, Papillary	Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis.
other	34800440	hsa-mir-130b	Thyroid Cancer, Papillary	Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis.
other	34800440	hsa-mir-424	Thyroid Cancer, Papillary	Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis.
other	34800440	hsa-mir-193b	Thyroid Cancer, Papillary	Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis.
circulation_biomarker_diagnosis_up	34800086	hsa-mir-4431	Obesity	RESULTS: Serum miR-4431 levels were significantly high in obese and type 2 diabetes mellitus individuals, and positively correlated with the body mass index and fasting plasma glucose levels.
circulation_biomarker_diagnosis_up	34800086	hsa-mir-4431	Diabetes Mellitus, Type 2	RESULTS: Serum miR-4431 levels were significantly high in obese and type 2 diabetes mellitus individuals, and positively correlated with the body mass index and fasting plasma glucose levels.
circulation_biomarker_diagnosis_up	34800057	hsa-mir-210	Squamous Cell Carcinoma of Head and Neck	METHODS The expression of EV-miR-210 was measured in the plasma of OSCC patients (n = 30) and compared to that of controls (n = 14).
lncRNA target	34799875	hsa-mir-198	Prostatic Neoplasms	In addition, miR-198 directly targeted homeobox A1 (HOXA1), and HOXA1 weakened miR-198 mimic-mediated impacts on PCa cell malignant phenotypes.
genetics_overexpression_promote	34799871	hsa-mir-21	Esophageal Squamous Cell Carcinoma	RESULTS: The population of IL-10 and TGF-beta-producing CTLs (CD8+ Tregs) were considerably expanded, in addition to the overexpression of miR-21 in both groups (ND and UT) of ESCC patients, while the frequency of Tc17 and CD8+ Treg cells increased only in UT patients.
genetics_overexpression_promote	34799871	hsa-mir-21	Esophageal Neoplasms	RESULTS: The population of IL-10 and TGF-beta-producing CTLs (CD8+ Tregs) were considerably expanded, in addition to the overexpression of miR-21 in both groups (ND and UT) of ESCC patients, while the frequency of Tc17 and CD8+ Treg cells increased only in UT patients.
genetics_GWAS	34799795	hsa-mir-19b	Glioma	In conclusion, by studying the changes in the key parameters of glioma patients who were subjected to radiotherapy, we concluded that the rs7853346 polymorphism in lncRNA-PTENP1 and the rs1799864 polymorphism in CCR2 could independently affect cognitive impairment, while a more significant combined effect on cognitive impairment was exerted in glioma patients via the signaling pathway of PTENP1/miR-19b/CCR2.
genetics_overexpression_promote	34799723	hsa-mir-519d	Prostatic Neoplasms	Overexpression of miR-519d-3p led to inhibited PCa cell proliferation, invasion and migration, and p53 overexpression was found to promote miR-519d-3p expression to suppress the malignant characteristics of PCa cells, while the additional E2F1 overexpression restored the malignant traits.
genetics_GWAS	34799665	hsa-mir-191	Infant, Low Birth Weight	3p was reliably different in individuals with LBW, and could be a new player in the epigenetic mechanisms connecting LBW and future endocrine-metabolic adverse outcomes.
genetics_knock down_promote	34798882	hsa-mir-149	Ovarian Neoplasms	3p overexpression in cisplatin-resistant OC cells led to contrary results.
other	34798868	hsa-mir-128a	Glioblastoma	3p and 17-5p for most of the cells.
other	34798868	hsa-mir-221	Glioblastoma	3p and 17-5p for most of the cells.
other	34798868	hsa-mir-34	Glioblastoma	3p and 17-5p for most of the cells.
lncRNA target	34798192	hsa-mir-146a	Zika Virus Infection	ZIKV-NS1 induced the expression of miR-146a and suppressed the ROS activity in human microglial cells.
genetics_overexpression_promote	34797887	hsa-mir-21	Breast Neoplasms	3p overexpression in breast tumors is a marker of worse breast cancer progression and it affects genes in pathways that drive breast cancer by down-regulating tumor suppressor genes.
transcription factor target	34797837	hsa-mir-3163	Triple Negative Breast Neoplasms	The results of current study suggest that CCNB1 and hsa-miR-3163 may serve as highly potential prognostic markers and therapeutic targets for AR positive TNBC.
other	34797582	hsa-mir-31	salivary gland adenoid cystic carcinoma	3p could be an independent prognostic factor for salivary adenoid cystic carcinoma.
transcription factor target	34797485	hsa-mir-1224	Cerebrovascular Disorders	This study aimed to investigate the function of miR-1224 in OGD/R-induced hippocampal neuron apoptosis, as well as the regulatory mechanism of miR-1224 in ischemic cerebrovascular disease. Our findings indicated that miR-1224 downregulation suppressed OGD/R-induced hippocampal neuron apoptosis by targeting Ku protein, suggesting that miR-1224 could serve as a new target for ischemic cerebrovascular disease treatment.
genetics_knock down_suppress	34797473	hsa-mir-491	Atherosclerosis	Circ_0003204 knockdown protects HUVECs against ox-LDL-induced injuries by targeting the miR5p-ICAM1 pathway, hinting that circ_0003204 inhibition might prevent AS development.
other	34797326	hsa-mir-155	Tuberculosis	Notably, the accuracy and efficacy of miRNA-155 in pediatric TB were higher than those in adult TB. CONCLUSION: The results of the meta-analysis suggested that miRNA-155 could serve as an effective biomarker for identifying active TB.
circulation_biomarker_prognosis_ns	34797300	hsa-mir-423	Heart Failure	In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR
circulation_biomarker_prognosis_ns	34797300	hsa-mir-18b	Heart Failure	In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR
circulation_biomarker_prognosis_ns	34797300	hsa-mir-18a	Heart Failure	In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR
other	34797299	hsa-mir-23a	Pulmonary Disease, Chronic Obstructive	5p, and miR-23a-5p might participate in the nosogenesis of COPD.
other	34797299	hsa-mir-194	Pulmonary Disease, Chronic Obstructive	5p, and miR-23a-5p might participate in the nosogenesis of COPD.
lncRNA target	34796909	hsa-mir-146a	Osteoarthritis	The present study revealed the protective effects of the FAM201A/miR146a5p/POU2F1 positive feedback loop on IL1betainduced chondrocyte injury and provided a potential therapeutic target for OA.
circRNA target	34796777	hsa-mir-1299	Lung Neoplasms	Furthermore, PDL1 was a functional target of miR-1299, and miR-1299 inhibited lung cancer cell development via decreasing PDL1 expression.
circulation_biomarker_diagnosis_up	34796469	hsa-mir-222	Pre-Eclampsia	3p inhibited HDAC6 expression and blocked the Notch1 signaling, thus suppressing trophoblast cell proliferation and migration and attenuating blood pressure and fetal detrimental changes in PE rats, which is expected to become a therapeutic target for PE.
other	34796453	hsa-mir-21	Stroke	Overall, the results of this study implicate miR-21 as a promising candidate for therapeutic translation after stroke.
lncRNA target	34796452	hsa-mir-3163	Nasopharyngeal Carcinoma	Overall, our data highlighted that CRNDE could promote NPC progression via altering miR-3163/TWIST1 axis, suggesting CRNDE as a potential prognostic biomarker and therapeutic target for NPC treatment.
other	34796409	hsa-mir-101	Osteoarthritis	3p were assessed as core miRNAs using overlapping analyses.
other	34796409	hsa-mir-451a	Osteoarthritis	3p were assessed as core miRNAs using overlapping analyses.
other	34796409	hsa-mir-210	Osteoarthritis	3p were assessed as core miRNAs using overlapping analyses.
other	34796409	hsa-mir-370	Osteoarthritis	3p were assessed as core miRNAs using overlapping analyses.
lncRNA target	34796378	hsa-mir-98	Polycystic Ovary Syndrome	3p targets and downregulates YY1 expression, thereby affecting the proliferation and apoptosis of OGCs in PCOS.
genetics_overexpression_promote	34796112	hsa-mir-200a	Glioma	Moreover, overexpression of miR-200a resulted in down-regulation of ZEB1 and further inhibited malignant phenotype of glioma cells.
genetics_overexpression_promote	34796092	hsa-mir-19a	Colorectal Neoplasms	Silencing of STAT3 reduced the hypoxia-induced activity of CRC cells, whereas the malignant behaviors of cells were restored after miR-19a upregulation but blocked after PTEN overexpression. This study demonstrated that hypoxia augments activity and malignant behaviors of colorectal cancer cells through the STAT3/miR-19a/PTEN/PI3K/AKT axis.
other	34795923	hsa-mir-1	Mesothelioma, Malignant, Pleural	The two-biomarker score is useful to identify a subgroup of e-MPM tumors characterized by BAP1 retained and high miR-31 levels with worse clinical outcome.
genetics_knock down_suppress	34795259	hsa-mir-1307	Pancreatic Carcinoma	Chemotherapy-induced apoptosis and DNA damage accumulation are higher in MIR1307 knock-out (MIR1307KO) versus control PDAC cells, while re-expression of MIR1307 in MIR1307KO cells rescues these effects.
genetics_overexpression_promote	34794217	hsa-mir-369	Carcinoma, Hepatocellular	3p+ pcDNA group, overexpression of ACTN4 increased the proliferation ability of hepatocellular carcinoma MHCC97H cells at 72 hours of culture[(1.12+/-0.11) vs (0.68+/-0.06), P<0.001], significantly reduced the proportion of cells in G(1) stage [(38.81+/-3.24)% vs (51.80+/-4.57)%, P<0.001], significantly increased the proportion of S-phase cells [(31.65+/-3.11)% vs (15.69+/-1.44)%, P<0.001], decreased cell apoptosis rate [(13.86+/-1.37)% vs (22.69+/-2.24)%, P<0.001], increased protein expressions of cyclin D1 and Bcl-2 (P<0.001), decreased the protein expressions of p21 and Bax (P<0.001).
other	34794216	hsa-mir-3666	Carcinoma, Hepatocellular	Pearson correlation was used to analyze the correlation between LINC00839 and miR-3666 expression in liver cancer tissues. The expression levels of LINC00839 and miR-3666 in liver cancer tissue were negatively correlated (r=-0.658, P<0.001).
lncRNA target	34793941	hsa-mir-342	Inflammation-Related  Depression	Here, we studied how peripubertal stress (PPS) combined with differential corticosterone (CORT)-stress responsiveness (CSR) influences depressive-like behaviors and brain inflammatory markers in male rats in adulthood, and how these alterations relate to microglia activation and miR-342 expression. Our work highlights miR-342 as a potential therapeutic target in inflammation-related depression.
genetics_knock down_promote	34793775	hsa-mir-30	Uterine Cervical Neoplasms	5p inhibition or MARK2 overexpression could countervail the suppressive effect of ABHD11-AS1 knockdown on CC cell malignant behaviors.
lncRNA target	34793694	hsa-mir-124	Huntington Disease	Proteomic analyses of the growth cones revealed that NUMA1 (nuclear/mitotic apparatus protein 1) is downregulated in HD by miR-124. Suppressing NUMA1 in wild-type cells recapitulates the microtubule and axonal growth defects of HD, whereas raising NUMA1 levels with antagomiR-124 or stabilizing microtubules with epothilone B restores microtubule organization and rescues axonal growth.
transcription factor target	34793551	hsa-mir-5195	Duane Retraction Syndrome	In summary, miR3p targeting GMFB might be a potential therapeutic target for DR.
genetics_overexpression_promote	34793477	hsa-mir-197	Carcinoma, Hepatocellular	3p was poorly expressed in HCC, while AGR2 was overexpressed.
other	34793290	hsa-mir-106b	Breast Neoplasms	3p, -193a-5p, and -10b-5p could detect early-stages of BC with 0.79 sensitivity, 0.86 specificity and 0.82 accuracy.
other	34793290	hsa-mir-106b	Breast Diseases	3p, -193a-5p, and -10b-5p could detect early-stages of BC with 0.79 sensitivity, 0.86 specificity and 0.82 accuracy.
genetics_knock down_promote	34793263	hsa-mir-582	Ovarian Neoplasms	3p promoted the proliferation and migration of OC cells, while overexpression inhibited them.
exosome	34792792	hsa-mir-1205	Colorectal Neoplasms	Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis. Altogether, these findings unraveled that circ_0006174-enriched exosomes elevated DOX chemoresistance in CRC by the miR-1205/CCND2 axis.
other	34792755	hsa-mir-146a	Fanconi Anemia	The decrease in miR-146a-5p was also validated using RT-qPCR and emerged as a strong candidate as a modulator of BM mRNAs in FA patients.
other	34792704	hsa-mir-486	Liposarcoma, Myxoid	Collectively, our observations clearly suggested that FUS-CHOP regulated myxoid liposarcoma cell proliferation and apoptosis by the regulation of miR-486/CDK4 axis, indicating the potential use of FUS-CHOP-siRNA as a promising therapy for myxoid liposarcoma.
other	34792645	hsa-mir-425	Esophageal Squamous Cell Carcinoma	3p, PIK3CD and CFL1 were associated with lipid regulation, cell proliferation and differentiation, so the two ceRNAs regulatory networks may play an important role in regulating intramuscular fat (IMF) deposition, thereby affecting pork quality.
genetics_knock down_promote	34792404	hsa-mir-16	Cardiomyopathies	Additionally, miRNA5p knockdown and miRNA-26a-5p overexpression significantly promoted cardiomyocyte hypertrophy in neonatal rat cardiomyocytes.
genetics_knock down_promote	34792404	hsa-mir-26a	Cardiomyopathies	Additionally, miRNA5p knockdown and miRNA-26a-5p overexpression significantly promoted cardiomyocyte hypertrophy in neonatal rat cardiomyocytes.
other	34791555	hsa-mir-127	Breast Neoplasms	The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924.
other	34791555	hsa-mir-132	Breast Neoplasms	The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924.
other	34791555	hsa-mir-125b-1	Breast Neoplasms	The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924.
other	34791555	hsa-mir-1258	Breast Neoplasms	The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924.
other	34791478	hsa-mir-16	Stomach Neoplasms	In this research, changes in the expression of B-cell lymphoma 2 (BCL2), miRb and miR-16 in human adenocarcinoma gastric cancer cell line (AGS) following the exposure to magnetic flux densities (MFDs) of 0.2 and 2 mT continuously and discontinuously (1.5 h on/1.5 h off) for 18 h were investigated.
other	34791478	hsa-mir-15b	Stomach Neoplasms	In this research, changes in the expression of B-cell lymphoma 2 (BCL2), miRb and miR-16 in human adenocarcinoma gastric cancer cell line (AGS) following the exposure to magnetic flux densities (MFDs) of 0.2 and 2 mT continuously and discontinuously (1.5 h on/1.5 h off) for 18 h were investigated.
other	34791059	hsa-mir-744	Ovarian Neoplasms	Moreover, mechanism analysis unveiled that NRSN2-AS1 functioned as a miR5p sponge to regulate PRKX expression in OV cells.
genetics_knock down_suppress	34790800	hsa-mir-139	Neurotic Disorders	5p gain- and loss-of-function on depression-like behaviors, the expression level of PDE4D, and hippocampus neurogenesis.
other	34790800	hsa-mir-139	Colorectal Neoplasms	Elisa, western blotting, and fluorescence in situ hybridization (FISH) were used to detect the expression of miR5p and PDE4D in CRC tissues.
other	34790783	hsa-mir-335	Esophageal Squamous Cell Carcinoma	COL11A1 promotes esophageal squamous cell carcinoma proliferation and metastasis and is inversely regulated by miR-335-5p.
lncRNA target	34790777	hsa-mir-181d	Kidney Diseases	Finally, we evaluated the effects of circRNA_0045861 target gene miR-181d-5p on UPJO-induced renal fibrosis in vivo. CONCLUSIONS: Circ_0045861 may be a novel candidate circRNA in the pathogenesis of UPJO by acting as a pro-apoptotic factor via the miR-181d-5p/SIRT1 axis.
lncRNA target	34790777	hsa-mir-181d	ureteropelvic junction obstruction	Finally, we evaluated the effects of circRNA_0045861 target gene miR-181d-5p on UPJO-induced renal fibrosis in vivo. CONCLUSIONS: Circ_0045861 may be a novel candidate circRNA in the pathogenesis of UPJO by acting as a pro-apoptotic factor via the miR-181d-5p/SIRT1 axis.
other	34790764	hsa-mir-16	Atherosclerosis	Our in vivo experiments also demonstrated that artesunate reduced lipid accumulation, atherosclerotic plaque formation, and antagonized inflammation in a dose-dependent manner by upregulating miR5p.
other	34790744	hsa-mir-744	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: In summary, our results confirmed for the first time the regulatory mechanism of CDX2 on miR-744 transcription and provided a potential mechanism for CDX2 as an oncogene in lung cancer.
lncRNA target	34790743	hsa-mir-34c	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: MiR-34c-5p regulates the proliferation, migration, invasion, and apoptosis of OSCC through targeted binding of TRIM29.
lncRNA target	34790726	hsa-mir-34a	Fibrosis	Moreover, miR-34a activates HSCs through transforming TGF-beta, alpha-smooth muscle actin (alpha-SMA), and Monocyte chemoattractant protein-1 (MCP-1), which further affects liver fibrosis.
other	34790674	hsa-mir-593	Uterine Cervical Neoplasms	5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer.
other	34790674	hsa-mir-16	Uterine Cervical Neoplasms	5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer.
other	34790674	hsa-mir-147a	Uterine Cervical Neoplasms	5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer.
other	34790674	hsa-mir-15b	Uterine Cervical Neoplasms	5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer.
other	34790674	hsa-mir-138	Uterine Cervical Neoplasms	5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer.
lncRNA target	34790580	hsa-mir-7	Colorectal Neoplasms	Restoration of HOXD10 activates the expressions of miR-7 and IGFBP3 and results in an inhibited phenotype biologically, suggesting its potential therapeutic relevance in colorectal cancer (CRC).
circulation_biomarker_diagnosis_down	34790566	hsa-mir-146a	Carcinoma, Non-Small-Cell Lung	Conclusions The current data suggest that the miR-146a expression in PBMC and serum TGF- and IL-1 levels may act as blood markers in NSCLC patients.
lncRNA target	34790379	hsa-mir-183	Stomach Neoplasms	5p participates in the tumorigenesis and development of GC via certain signaling pathways, in particular the nerve- and immunity-related genes.
target gene	34790377	hsa-mir-206	Esophageal Neoplasms	Long non-coding RNA HAGLROS regulates the proliferation, migration, and apoptosis of esophageal cancer cells via the HAGLROS-miR-206-NOTCH3 axis.
target gene	34790374	hsa-mir-873	Stomach Neoplasms	MiR-873-5p targets THUMPD1 to inhibit gastric cancer cell behavior and chemoresistance.
lncRNA target	34790286	hsa-mir-574	Stroke	CONCLUSION: circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury.
lncRNA target	34790286	hsa-mir-574	Hypoxia-Ischemia, Brain	CONCLUSION: circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury.
circulation_biomarker_diagnosis_ns	34790240	hsa-mir-133	Thrombocytopenia	The proportion of Bregs and the IL-10 secretion could be further promoted by the UC-MSCs treated with 0.1 mug/mL SDF-1alpha, which could also promote the miRNA-133 expression of UC-MSCs in an exosome-dependent manner; moreover, while the UC-MSCs were transfected with the miR-133 inhibitor, the proportion of induced Bregs decreased obviously when cocultured with peripheral blood mononuclear cells (PBMCs) of ITP. We conclude that UC-MSCs could effectively enhance the decreased proportion of Bregs from ITP; at appropriate concentrations, SDF-1alpha may promote the proliferating and survival ability of UC-MSCs and improve the production of Bregs induced by UC-MSCs through controlling miRNA-133 expression in the exosomes.
other	34790229	hsa-mir-16	Diabetic Nephropathies	5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN.
other	34790229	hsa-mir-27a	Diabetic Nephropathies	5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN.
other	34790229	hsa-let-7b	Diabetic Nephropathies	5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN.
other	34790229	hsa-mir-93	Diabetic Nephropathies	5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN.
lncRNA target	34790052	hsa-mir-93	Small Cell Lung Carcinoma	5p, which may be potential targets for SCLC patients.
other	34789642	hsa-mir-143	Aortic Aneurysm, Abdominal	Direct relationship miR3p and circ-FNDC3B or ADAM10 was verified by dual-luciferase reporter and RNA immunoprecipitation assays.Circ-FNDC3B was highly expressed in AAA tissues and Ang-II-treated VSMCs.
other	34789323	hsa-mir-28	Fetal Growth Retardation	miR5p was reduced in FGR pregnancies (p < 0.01) only when there was a female offspring and miR-301a-3p was only reduced in FGR pregnancies with a male fetus (p < 0.05).
genetics_knock down_suppress	34789312	hsa-mir-497	Endometrial Neoplasms	5p or increase in FASN could neutralize the modulatory actions of SNHG25 knockdown in EC cells.
lncRNA target	34789310	hsa-mir-129	Ovarian Neoplasms, High-Grade Serous	3p repressed SOC cell processes via binding to MAP3K3.
other	34789303	hsa-mir-544	Ovarian Neoplasms	miR5p expression was decreased, while SOX12 expression was increased in OC tumor tissues and cells.
lncRNA target	34789303	hsa-mir-744	Ovarian Neoplasms	CONCLUSION: MNX1-AS1 promoted the development of OC through miR5p/SOX12 axis.
lncRNA target	34789275	hsa-mir-20a	Non-alcoholic Fatty Liver Disease	CircRNA_0001805 targeted miR-106a-5p/miR-320a, which served as an upstream inhibitor of ABCA1/CPT1 and collaboratively regulated NAFLD progression.
lncRNA target	34789275	hsa-mir-106a	Non-alcoholic Fatty Liver Disease	CircRNA_0001805 targeted miR-106a-5p/miR-320a, which served as an upstream inhibitor of ABCA1/CPT1 and collaboratively regulated NAFLD progression.
target gene	34789263	hsa-mir-365a	Breast Neoplasms	The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling.
other	34789260	hsa-mir-217	Gallbladder Neoplasms	CONCLUSIONS: Our findings demonstrated that circTP63 sponged to miR-217 and regulated EZH2 expression and finally facilitated tumor progression in GBC.
genetics_overexpression_suppress	34789086	hsa-mir-204	Leukemia, Myeloid, Acute	HGF overexpression reversed the effects of miR-204 mimic on AML cell proliferation, apoptosis, migration, and invasion.
genetics_GWAS	34788764	hsa-mir-142	Femur Head Necrosis	CONCLUSION: Our results first confirm that the genetic polymorphism of MIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population.
circulation_biomarker_prognosis_ns	34788749	hsa-mir-122	Liver Neoplasms	CONCLUSIONS: Longitudinal examination of serial liver biopsies indicated that the circulating miR-122 dynamics might be useful in predicting the prognosis for NAFLD patients with severe fibrosis stage and no improvement of the stage scores.
circulation_biomarker_prognosis_ns	34788749	hsa-mir-122	Non-alcoholic Fatty Liver Disease	CONCLUSIONS: Longitudinal examination of serial liver biopsies indicated that the circulating miR-122 dynamics might be useful in predicting the prognosis for NAFLD patients with severe fibrosis stage and no improvement of the stage scores.
circulation_biomarker_diagnosis_down	34788141	hsa-mir-106b	Multiple Sclerosis	Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR
circulation_biomarker_diagnosis_down	34788141	hsa-mir-132	Multiple Sclerosis	Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR
circulation_biomarker_diagnosis_down	34788141	hsa-mir-19b	Multiple Sclerosis	Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR
other	34787848	hsa-mir-1827	Breast Neoplasms	By negatively regulating miR-1827 level, LINC00174 aggravates the malignant development of BCa.
transcription factor target	34787641	hsa-mir-181a	Diabetes Mellitus, Type 2	Furthermore, we revealed that Rik may positively impact diabetic corneal epithelial wound healing by sponging miR-181a-5p, providing a novel potential therapeutic target of diabetic keratopathy (DK).
genetics_knock down_promote	34787343	hsa-mir-886	Prostatic Neoplasms	The knockdown of miR-886 inhibits cellular processes of prostate cancer, which provides a novel therapeutic target.
lncRNA target	34787069	hsa-mir-199a	Epilepsy, Temporal Lobe	LncRNA TUG1 may be a biomarker of TLE diagnosis in children, and can regulate hippocampal neuron cell activity and apoptosis via sponging miR-199a-3p.
other	34787068	hsa-mir-1	Thromboangiitis Obliterans	3p/GNA12 signaling as a novel mechanism for TAO progression.
lncRNA target	34787066	hsa-mir-1296	Breast Neoplasms	Collectively, it is concluded that circ_0048764 promotes the development of BC via modulating the miR
genetics_knock down_promote	34787058	hsa-mir-107	Wilms Tumor	In addition, circSLC7A6 knockdown inhibited WT progression, while the effect was partially abolished by the downregulation of miR-107. In conclusion, the present study demonstrated that circSLC7A6 facilitated WT progression by upregulating ABL2 through inhibiting miR-107 expression.
lncRNA target	34787053	hsa-mir-28	Chromate Resistance	To sum up, our findings, for the first time, demonstrated that DEX exerted neuroprotective effects on hippocampal neurons against H/R treatment via the circ-CDR1as/miR3p/TRAF3 regulatory network, providing novel therapeutic targets for DEX administration in CI/R treatment.
lncRNA target	34787053	hsa-mir-28	Osteoarthropathy, Primary Hypertrophic	To sum up, our findings, for the first time, demonstrated that DEX exerted neuroprotective effects on hippocampal neurons against H/R treatment via the circ-CDR1as/miR3p/TRAF3 regulatory network, providing novel therapeutic targets for DEX administration in CI/R treatment.
genetics_overexpression_suppress	34787051	hsa-mir-543	Breast Neoplasms	Furthermore, miR-543 overexpression undermined the UBE2T promotional effect by inhibiting ERK/MAPK pathway activity in breast cancer cells.
other	34787047	hsa-mir-103a	Triple Negative Breast Neoplasms	Collectively, PCAT18 was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote ATF7 expression, resulting in prevention of TNBC metastasis.
genetics_overexpression_promote	34786378	hsa-mir-532	Carcinoma, Hepatocellular	5p overexpression on HCC cell proliferation, migration and invasion.
target gene	34786212	hsa-mir-204	Breast Neoplasms	DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer.
circulation_biomarker_diagnosis_up	34786210	hsa-mir-188	Carcinoma, Hepatocellular	Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma.
lncRNA target	34786209	hsa-mir-199a	Cardiomegaly	This study suggests a possible new strategy for cardiac remodeling therapy by inhibiting miR-199a-5p and -3p.
lncRNA target	34786209	hsa-mir-199a	Diabetic Nephropathies	This study suggests a possible new strategy for cardiac remodeling therapy by inhibiting miR-199a-5p and -3p.
lncRNA target	34786084	hsa-mir-378b	Hypoxia-Ischemia, Brain	Overall, the present findings suggest that ANRIL exerts its protective effects via binding to miR-378b and upregulating ATG3 expression, suggesting the potential of ANRIL as a protective target for HIBD.
circulation_biomarker_prognosis_up	34786079	hsa-mir-506	Liver Neoplasms	Cox proportional hazards regression model analysis revealed that TNM staging and low serum miR
transcription factor target	34786071	hsa-mir-21	Sepsis	5p, and both molecules serve as potential therapeutic targets for heart sepsis patients.
target gene	34786067	hsa-mir-429	Triple Negative Breast Neoplasms	ln RNA LINC01234 promotes triple-negative breast cancer progression through regulating the miR-429/SYNJ1 axis.
lncRNA target	34786066	hsa-mir-22	Pneumonia	Also, LncRNA H19 acts as a sponge of miR3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis.
genetics_overexpression_promote	34786062	hsa-mir-486	Asthma, Allergic	Overexpression of miR
lncRNA target	34786060	hsa-mir-146a	Diabetes Mellitus, Type 2	OBJECTIVE: To investigate the effect of long non-coding RNA (LncRNA) PTGS2 on islet beta-cell function via the miR-146a-5p/Retinol binding protein 4 (RBP4) axis and its diagnostic value in type 2 diabetes mellitus (T2DM).
circulation_biomarker_prognosis_up	34786057	hsa-mir-18a	Vascular Malformations	Thus, we identified a prognostic serum miR-18a-5p and validated its function in VM.
target gene	34786052	hsa-mir-21	Colorectal Neoplasms	m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis.
other	34786048	hsa-mir-144	Colorectal Neoplasms	LncRNA SNHG4 promotes malignant biological behaviors and immune escape of colorectal cancer cells by regulating the miR-144-3p/MET axis.
lncRNA target	34786045	hsa-mir-4731	Breast Neoplasms	5p to modulate BC progression through FOXM1.
circulation_biomarker_diagnosis_up	34786043	hsa-mir-214	Tibial Fractures	3p, and it is related to promoting the osteoblast proliferation, inhibiting apoptosis, and up-regulating the serum ALP and OPG levels to accelerate bone healing.
other	34786024	hsa-mir-146a	ST Elevation Myocardial Infarction	STEMI patients with high levels of miR-146a had a higher risk of major adverse cardiovascular events (MACEs) than those with low levels of miR-146a (log-rank P = 0.034). CONCLUSION: The incidence of MACEs in STEMI patients expressing high levels of miR-146a was significantly greater than in those expressing low levels.
target gene	34785951	hsa-mir-198	Breast Neoplasms	A Novel Circular RNA circPTCD3 Promotes Breast Cancer Progression Through Sponging miR-198.
lncRNA target	34785791	hsa-mir-15a	Histiocytosis	Our findings suggest that miR-15a-5p is a tumor suppressor in ECD through the CXCL10-ERK-LIN28a-let7 axis, highlighting another layer of post-transcriptional regulation in this disease.
genetics_overexpression_promote	34785625	hsa-mir-296	Triple Negative Breast Neoplasms	Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR
other	34785595	hsa-mir-106b	Epilepsy	These results unmask a regulatory mechanism of KCNQ2 channel expression in early postnatal development and hint at a role for miR-106b up-regulation in the pathophysiology of epilepsy.
other	34785326	hsa-mir-181a	Nephrotic Syndrome	The (miR-142a-5p with miR-181a-5p and miR-30a-5p) was the best expression panel to diagnose new NS cases and predict steroid resistance.
lncRNA target	34785240	hsa-mir-126	Myocardial Ischemia	MicroRNA-126 (miR-126) has been identified as the main regulator of compensatory angiogenesis; however, its role in MI is unclear. In summary, miR-126 regulates the occurrence and progression of angiogenesis during MI via HIF-1alpha and may be a potential new therapeutic target.
transcription factor target	34785144	hsa-mir-192	Inflammation	CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition.
transcription factor target	34785144	hsa-mir-192	Syphilis	CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition.
transcription factor target	34785144	hsa-mir-192	Pancreatitis	CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition.
lncRNA target	34785106	hsa-mir-23a	Liver Diseases, Alcoholic	CONCLUSIONS: We first demonstrated that ISL could alleviate ALD, and further verified that ISL exerted protective effects through modulating miR-23a-3p/PGC-1alpha-mediated lipid metabolism in vivo and in vitro.
genetics_knock down_suppress	34784955	hsa-mir-20a	Ovarian Neoplasms	SMG1 was targeted by miR-320a, and its knockdown also reversed the regulation of miR-320a inhibitor on the proliferation and apoptosis of ovarian cancer cells. CONCLUSION: Curcumin restrained proliferation and facilitated apoptosis in ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 axis.
genetics_overexpression_promote	34784841	hsa-mir-381	Sepsis	Overexpression of miR
genetics_overexpression_promote	34784841	hsa-mir-381	Inflammation	Overexpression of miR
genetics_overexpression_promote	34784837	hsa-mir-455	Intrauterine Adhesion	5p overexpression in UCMSCs helps to attenuate endometrial injury and repair damaged endometrium by activating SOCS3-mediated JAK/STAT3 signaling.
transcription factor target	34784802	hsa-mir-126	COVID-19	3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19.
transcription factor target	34784802	hsa-mir-144	COVID-19	3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19.
transcription factor target	34784802	hsa-mir-155	COVID-19	3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19.
transcription factor target	34784802	hsa-mir-146a	COVID-19	3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19.
transcription factor target	34784802	hsa-mir-21	COVID-19	3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19.
transcription factor target	34784607	hsa-mir-1228	Diabetic Nephropathies	RESULTS: The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228.
transcription factor target	34784607	hsa-mir-1228	Norrie disease	RESULTS: The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228. miR-1228 was downregulated in DN and HG-damaged HK-2 cells.
genetics_knock down_promote	34784607	hsa-mir-1228	Hyperglycemia	In terms of overexpression and knockdown experiments, Western blot analysis further revealed that miR-1228 inhibited the activation of the PI3K/AKT signaling pathway in HG-damaged HK-2 cells by regulating THBS2.
genetics_overexpression_promote	34784561	hsa-mir-1294	Dermatitis, Atopic	Inflammation (P < 0.05) and epidermal barrier function destruction (P < 0.05) in AD was suppressed by overexpression of miR-1294 but enhanced by STAT3 upregulation and its downstream NF-kappaB pathway.
genetics_overexpression_promote	34784519	hsa-mir-1258	Carcinoma, Hepatocellular	Moreover, ectopic overexpression of miR-1258 suppressed cell growth and metastasis in HCC, which was abolished by SERBP1 up-regulation.
exosome	34784377	hsa-mir-196a	pancreatic adenocarcinoma	qRT-PCR analysis of miRNA expression in EVs from PDAC cells revealed that expression of miR-196a and miR-1246, two previously identified miRNAs highly enriched in PDAC cell-derived exosomes, is significantly elevated in the OP1 group relative to the other EV groups.
exosome	34784377	hsa-mir-1246	pancreatic adenocarcinoma	qRT-PCR analysis of miRNA expression in EVs from PDAC cells revealed that expression of miR-196a and miR-1246, two previously identified miRNAs highly enriched in PDAC cell-derived exosomes, is significantly elevated in the OP1 group relative to the other EV groups.
transcription factor target	34784311	hsa-mir-544	Arthritis	3p as a new potential therapeutic target for treating RA pain.
genetics_knock down_promote	34784267	hsa-mir-577	Glioblastoma	E2F5 was a target of miR-577, and the effect of its knockdown on GBM progression was consistent with that of circFOXM1 silencing.
transcription factor target	34784010	hsa-mir-106a	Carcinoma, Hepatocellular	Besides, PTPN12 counteracted the promoting effects of miR-106a-5p on the viability, migration, invasion, and EMT of HCC cells. In conclusion, this study substantiates that PTPN12 inhibits the growth, migration, invasion, and EMT of HCC cells, and miR-106a-5p contributes to its dysregulation in HCC.
genetics_knock down_suppress	34783894	hsa-mir-543	Breast Neoplasms	CONCLUSION: Our study suggested that SNHG14 knockdown hindered BC progression in vitro at least partly through acting as a ceRNA of miR-543 and modulating KLF7 expression, providing evidence for SNHG14 as a potential target for BC therapy.
genetics_knock down_promote	34783868	hsa-mir-204	Kidney Calculi	Gain- and loss-of-function approaches were employed to alter the expression of miR-204/MUC4 so as to assess the detailed role of miR-204 in oxidative stress injury in renal tubular epithelial cells (RTECs) and calcium oxalate kidney-stone formation.
lncRNA target	34783641	hsa-mir-31	Breast Neoplasms	We aimed to evaluate the effects of long-chain non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the proliferation, invasion, and migration of breast cancer cells by targeting miR-331. LncRNA ANCR expressions in breast cancer and adjacent tissues, human breast cancer cells and mammary epithelial cells, and miR-331 expressions in interfering cell line MDA-MB-231 (MCF-7)-shANCR, negative control MDA-MB-231 (MCF-7)-shNC and blank control MDA-MB-231 (MCF-7) were detected by real-time quantitative PCR.
genetics_knock down_promote	34783632	hsa-mir-512	Arteriosclerosis	Mechanistically, knockdown of miR
lncRNA target	34783627	hsa-mir-212	Acute Kidney Injury	In conclusion, KCNQ1OT1 aggravates acute kidney injury by activating p38/NF-kappaB pathway via miR3p/MAPK1 axis in sepsis.
lncRNA target	34783627	hsa-mir-212	Sepsis	In conclusion, KCNQ1OT1 aggravates acute kidney injury by activating p38/NF-kappaB pathway via miR3p/MAPK1 axis in sepsis.
lncRNA target	34783622	hsa-mir-204	Carcinoma, Renal Cell	5p reduction reversed the inhibitory effect of LINC01232 silencing on ccRCC cell function.
lncRNA target	34783303	hsa-mir-138	Parkinson Disease	5p/NFIB axis, providing new therapeutic targets for patients with PD.
transcription factor target	34783294	hsa-mir-27b	Inflammation	In the meanwhile, Gm5106 was identified as a direct target of miR-27b-3p that was inhibited by sevoflurane and related to inflammation suppression.
genetics_GWAS	34783292	hsa-mir-34a	Osteoarthritis	Using miRNA-based microarray analysis, we found that miR-34a was overexpressed in cartilage tissues of OA patients relative to patients with acute traumatic amputations.
genetics_knock down_promote	34783290	hsa-mir-200c	Venous Thromboembolism	VTE rats were injected with miR-200c-3p inhibitor for 24 h to investigate whether miR-200c-3p knockdown influences thrombus formation in vivo.
lncRNA target	34783233	hsa-mir-873	Carcinoma, Hepatocellular	Moreover, GTPBP4 was identified as direct downstream target of miR
circRNA target	34783205	hsa-mir-545	Endometrial Neoplasms	3p/FAM98A axis, providing a potential therapeutic target for ECa.
genetics_overexpression_suppress	34783198	hsa-mir-411	Fibrosis, Skin	Overexpression of miR
lncRNA target	34783160	hsa-mir-193a	Melanoma	In addition, we discovered that LINC01224 upregulated NR1D2 expression by sponging miR-193a-5p in melanoma cells. Overall, the data collected in this study suggest that LINC01224 exerts oncogenic effects in melanoma via the miR-193a-5p/NR1D2 axis.
lncRNA target	34782005	hsa-mir-339	Colorectal Neoplasms	Our mechanistic investigations demonstrated, for the first time, that SNHG17 promotes tumor growth and metastasis through two different regulatory mechanisms, SNHG17-Trim23-PES1 axis and SNHG17-miR5p-FOSL2-SNHG17 positive feedback loop, which may be exploited for CRC therapy.
genetics_GWAS	34781979	hsa-mir-155	Femur Head Necrosis	Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH.
other	34781940	hsa-mir-378a	Atrial Fibrillation	Two significant modules (red and blue) and hub miRNAs (hsa-miR-146b-5p and hsa-miR-378a-5p), which highly correlated with AF-related phenotype, were detected by WGCNA.
other	34781940	hsa-mir-146b	Atrial Fibrillation	Two significant modules (red and blue) and hub miRNAs (hsa-miR-146b-5p and hsa-miR-378a-5p), which highly correlated with AF-related phenotype, were detected by WGCNA.
circRNA target	34781898	hsa-mir-203	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637.
circRNA target	34781898	hsa-mir-637	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637.
lncRNA target	34781815	hsa-mir-1	Thyroid Cancer, Papillary	5p to upregulate SIDT2, thereby inhibiting the viability, proliferation, migration, invasion, and the secretion of vascular endothelial growth factor (VEGF) of PTC cells and angiogenesis of human umbilical vein endothelial cells (HUVECs).
other	34781814	hsa-mir-515	Squamous Cell Carcinoma of Head and Neck	Thus, these findings highlight that circANKS1B might act as an oncogenic gene to facilitate the metastatic potential and cisplatin resistance in OSCC by sponging miR5p to regulate TGF-beta1.
other	34781178	hsa-mir-21	Stomach Neoplasms	Herein, we report the novel fluorescent paper-based analytical devices (PADs) for detections of GC-related microRNA-21 (miRNA-21) and circular RNA from Hippocampus Abundant Transcript 1 gene (circRNA-HIAT1) with prominent reliability and sensitivity.
other	34781166	hsa-mir-455	Alzheimer Disease	3p against AD toxicities in reducing full-length APP and amyloid-beta (Abeta) levels, and also in reducing defective mitochondrial biogenesis, impaired mitochondrial dynamics and synaptic deficiencies.
other	34781085	hsa-mir-7	Acidosis	In addition, acidosis had a strong effect on cell adhesion, which could be modulated by miR-7, miR-203 and miR-215.
other	34781085	hsa-mir-203	Acidosis	In addition, acidosis had a strong effect on cell adhesion, which could be modulated by miR-7, miR-203 and miR-215.
lncRNA target	34780888	hsa-mir-1208	Atherosclerosis	Altogether, HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates the formation of foam cells within AS.
transcription factor target	34780785	hsa-mir-22	Atherosclerosis	However, a certain role of miR-22 in the pathogenesis of atherosclerosis remains undetermined. Collectively, these evidences revealed that miR-22 inhibition promoted the atherosclerosis progression through activation of IRF5.
other	34780678	hsa-mir-519d	Osteosarcoma	We found that PD-L1 expression was positively correlated to cisplatin resistance and metastasis, whereas miR-519d-3p expression was reduced in cisplatin-resistant specimens and was negatively correlated to cisplatin resistance and metastasis of osteosarcoma.
other	34780054	hsa-mir-29c	Carcinoma, Hepatocellular	CONCLUSIONS: Our results revealed a novel role of miR-653 and miR-29c in regulation of expresion of CYPs involved in crucial biotransformation processes in liver, which are often deregulated during liver cancer progression.
other	34780054	hsa-mir-653	Carcinoma, Hepatocellular	CONCLUSIONS: Our results revealed a novel role of miR-653 and miR-29c in regulation of expresion of CYPs involved in crucial biotransformation processes in liver, which are often deregulated during liver cancer progression.
transcription factor target	34779995	hsa-mir-674	Glioma	5p suppressed glioma cell proliferation and migration by targeting Cul4b.
transcription factor target	34779712	hsa-mir-222	Neural Tube Defects	3p regulates the Wnt/beta-catenin signaling pathway through Ddit4 inhibition in HT-22 cells, resulted in cell proliferation and apoptosis imbalance, and thus led to neural tube defects.
lncRNA target	34779502	hsa-mir-190b	Pancreatic Carcinoma	In addition, it was also found that miR190b directly targeted myocyte enhancer factor 2C (MEF2C) and transcription factor 4 (TCF4) in pancreatic cancer, thus serving as a tumor suppressor and a predictor of good prognosis in pancreatic cancer.
lncRNA target	34779493	hsa-mir-377	Uterine Cervical Neoplasms	In conclusion, suppression of NEAT1 inhibited cell viability and migration, and promoted apoptosis of CC cells, and these effects were achieved through regulation of the miR377/FGFR1 axis.
other	34778942	hsa-mir-152	Carcinoma, Hepatocellular	CONCLUSIONS: LncSNHG3 acted as an oncogene and promoted the EMT procession in HCC by binding miR3p and promoting JAK1 expression.
lncRNA target	34778905	hsa-mir-21	Osteoporosis	CONCLUSION: In summary, LINC02381 repressed osteogenic differentiation of hUS-MSCs through sponging miR-21 to enhance KLF12-mediated inactivation of Wnt/beta-catenin pathway, indicating that LINC02381 might be a therapeutic target for osteoporosis.
lncRNA target	34778900	hsa-mir-34a	Pulmonary Embolism	RESULTS: MiR-34a-3p expression was down-regulated in APE patients, which attenuated the increment of mPAP and thickening of the pulmonary arterial walls in APE rats, accompanied with regulation of NOR-1 and PCNA levels. CONCLUSION: Up-regulated miR-34a-3p negatively regulates DUSP1 expression to inhibit PASMC proliferation, which, thus, may act on APE treatment by negatively regulating pulmonary vascular proliferation.
genetics_overexpression_suppress	34778448	hsa-mir-1226	Hypertension	3p and eNOS were, respectively, found in the PAH rats and rPAECs, and overexpressed miR
other	34778258	hsa-mir-181a	Osteoarthritis	Moreover, we observed that a tight correlation between miR-181a and miR-218 expression levels in healthy human cartilage tissue was disrupted in osteoarthritis (OA) highlighting the importance of the WNT-BMP signaling crosstalk for preventing OA.
other	34778258	hsa-mir-218	Osteoarthritis	Moreover, we observed that a tight correlation between miR-181a and miR-218 expression levels in healthy human cartilage tissue was disrupted in osteoarthritis (OA) highlighting the importance of the WNT-BMP signaling crosstalk for preventing OA.
other	34778251	hsa-mir-129	Lymphoma, Large B-Cell, Diffuse	In conclusion, we showed for the first time that the mir5P/ARID3A negative feedback loop modulates DLBCL progression and immune evasion by regulating PD-1/PD-L1.
other	34778090	hsa-mir-375	Squamous Intraepithelial Lesions	In HPV 16-positive women, miR-375 positivity had higher sensitivity and NPV but lower specificity and PPV than that of cytology (>/=ASC-H and HSIL) in identifying CIN3+ and CIN2+.
other	34778090	hsa-mir-375	Cervical Intraepithelial Neoplasia	The immediate CIN3+ risk of miR-375 positivity was 19.8% (61/308) in HPV-positive, 10.8% (22/204) in HR12-positive, and 43.5% (37/85) in HPV16-positive women, respectively.
other	34778090	hsa-mir-375	Uterine Cervical Neoplasms	CONCLUSION: The detection of miR-375 in cervical exfoliated cells may be an optional method for triaging primary HPV-positive women in population-based cervical cancer screening.
other	34778090	hsa-mir-375	Uterine Cervical Diseases	RESULTS: In valid 9,972 women aged 25-65, miR-375 expression showed a downward trend along with an increase in cervical lesion severity.
other	34778090	hsa-mir-375	Papillomavirus Infections	CONCLUSION: The detection of miR-375 in cervical exfoliated cells may be an optional method for triaging primary HPV-positive women in population-based cervical cancer screening.
transcription factor target	34778074	hsa-mir-29c	Stomach Neoplasms	Furthermore, we identified miR-29c as a negative regulator of JARID1B in GC. pylori caused downregulation of miR-29c in human GC and thereby contributed to JARID1B upregulation through relieving posttranscriptional regulation.
transcription factor target	34778021	hsa-mir-4443	Esophageal Squamous Cell Carcinoma	5p and miR-4443 may serve as a novel molecular target for ESCC treatment.
transcription factor target	34778021	hsa-mir-17	Esophageal Squamous Cell Carcinoma	5p and miR-4443 may serve as a novel molecular target for ESCC treatment.
exosome	34777698	hsa-mir-4454	Carcinoma, Hepatocellular	Meanwhile, we certified that miR-4454 in exosomes could provide a novel and effective mechanism for HCC function.
genetics_overexpression_promote	34777696	hsa-mir-21	Glioma	5p or overexpression of CASKIN1 annulled the effects of LINC00294 silencing on mitochondrial function and glioma cell apoptosis under hypoxia.
lncRNA target	34777635	hsa-let-7f	Aortic Aneurysm, Abdominal	Furthermore, the expression of SOD2 and CCR7 may be regulated by hsa_circ_0011449/hsa_circ_0081968/hsa-let-7f-5p; the expression of PGRMC1 may be regulated by hsa_circ_0011449/hsa_circ_0081968-hsa-let-7f-5p/hs CONCLUSION: In conclusion, the ceRNA interaction axis we identified may be an important target for the treatment of abdominal aortic aneurysms.
genetics_knock down_promote	34777589	hsa-mir-1179	Gallbladder Neoplasms	Notably, E2F2 knockdown partially hindered the effects of TMPO-AS1/miR-1179 on the proliferation and metastasis of GBC cell lines.
genetics_GWAS	34777472	hsa-mir-3928	Arthritis, Rheumatoid	Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population.
genetics_GWAS	34777472	hsa-mir-4482	Arthritis, Rheumatoid	Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population.
genetics_GWAS	34777472	hsa-mir-4308	Arthritis, Rheumatoid	Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population.
genetics_GWAS	34777472	hsa-mir-135b	Arthritis, Rheumatoid	Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population.
other	34777462	hsa-mir-16	Leukemia, Myeloid, Acute	5p/CCL5 may play an important role in AML.
other	34777462	hsa-mir-17	Leukemia, Myeloid, Acute	5p/CCL5 may play an important role in AML.
circulation_biomarker_diagnosis_up	34777204	hsa-mir-181b	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
circulation_biomarker_diagnosis_up	34777204	hsa-mir-27b	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
circulation_biomarker_diagnosis_up	34777204	hsa-mir-101a	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
circulation_biomarker_diagnosis_up	34777204	hsa-mir-150	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
circulation_biomarker_diagnosis_up	34777204	hsa-mir-16	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
circulation_biomarker_diagnosis_up	34777204	hsa-let-7b	Hemorrhagic Stroke	5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR
lncRNA target	34776969	hsa-mir-149	Arthritis, Rheumatoid	Thus, we elucidate a previously unknown mechanism between circRNAs and RA, and ATO has a significant protective effect on RA-FLS and CIA synovium via its inhibition of the angiogenic functional module of circHIPK3/miR5p/FOXO1/VEGF, suggesting great potential for the combination therapy of ATO with circHIPK3 silencing.
other	34776961	hsa-mir-122	Lipid Metabolism Disorders	kingianum can reduce insulin resistance and restore the gut microbiota in a rat model of aberrant lipid metabolism by down regulating miR-122.
transcription factor target	34776924	hsa-mir-214	Parkinson Disease	We previously identified that miR-31 and miR-214 were dysregulated in PD.
other	34776924	hsa-mir-1	Parkinson Disease	In addition, the expression of miR-214 was lower in aPD patients compared to both dnPD or pPD patients, while the expression of miR-31 was higher in aPD patients compared to dnPD patients.
lncRNA target	34776870	hsa-mir-106b	Neurodegenerative Diseases	Our results suggest propofol inhibits microglial activation via miR-106b/Pi3k/Akt axis, shedding light on a novel molecular mechanism of propofol-mediated immunomodulatory effects and implying propofol as potential therapeutics for treating neuroinflammation-related neurodegenerative diseases.
lncRNA target	34776870	hsa-mir-106b	Neurogenic Inflammation	Our results suggest propofol inhibits microglial activation via miR-106b/Pi3k/Akt axis, shedding light on a novel molecular mechanism of propofol-mediated immunomodulatory effects and implying propofol as potential therapeutics for treating neuroinflammation-related neurodegenerative diseases.
transcription factor target	34776863	hsa-mir-1254	sporatic amyotrophic lateral sclerosis	Two miRNAs were dysregulated in all three tissues: miR3p was increased in ALS, and miR-1254 was reduced in ALS.
transcription factor target	34776863	hsa-mir-342	sporatic amyotrophic lateral sclerosis	Two miRNAs were dysregulated in all three tissues: miR3p was increased in ALS, and miR-1254 was reduced in ALS.
target gene	34776628	hsa-mir-194	Psoriasis	Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis.
other	34776451	hsa-let-7d	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-181a	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-let-7i	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-151	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-539	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-132	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-23a	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-34b	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-99a	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-126	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
other	34776451	hsa-mir-150	Alzheimer Disease	5p, miR-181a) and females (miR-150, miR-539).
exosome	34775889	hsa-mir-129	Colonic Neoplasms	Exosomes containing miRNA
other	34775880	hsa-mir-381	Asthma	3p-mediated PPP3CA/calcineurin signalling regulated iNOS transcription in macrophages and bronchoalveolar lavage cells (BALCs) after acute MDI exposure; however, whether PPP3CA/calcineurin signalling participates in regulation of other asthma-associated mediators secreted by macrophages/BALCs after MDI exposure is unknown.Several asthma-associated, macrophage-secreted mediator mRNAs from MDI exposed murine BALCs and MDI-glutathione (GSH) conjugate treated differentiated THP-1 macrophages were analysed using RT-qPCR.Endogenous IL1B, TNF, CCL2, CCL3, CCL5, and TGFB1 were upregulated in MDI or MDI-GSH conjugate exposed BALCs and macrophages, respectively.
transcription factor target	34775599	hsa-mir-590	Inflammation	Therefore, miR3p may be a promising therapeutic target for SLE and other Th17 cell-dependent autoimmune diseases.
transcription factor target	34775599	hsa-mir-590	Lupus Erythematosus, Systemic	Therefore, miR3p may be a promising therapeutic target for SLE and other Th17 cell-dependent autoimmune diseases.
lncRNA target	34775495	hsa-mir-155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	5p can promote the development of cALL via the regulation on CBL-mediated IRF4/CDK6 axis.
lncRNA target	34775467	hsa-mir-942	Carcinoma, Renal Cell	This study provides a novel regulatory model of circRNA via forming a positive-feedback loop that perpetuates the circESRP1/miR-3942/CTCF axis, suggesting that this signaling may serve as a novel target for the treatment of ccRCC.
lncRNA target	34775378	hsa-mir-15a	Glioma	Present study showed that deletion of miR-15a inhibited the activation of EMT signaling via targeting Smad7, thus suppressed the tumorigenesis and tumor growth of glioma.
transcription factor target	34775375	hsa-mir-6745	Stomach Neoplasms	TIMP1 axis regulates Wnt/betacatenin signaling and participates in GC tumorigenesis and provide a potential therapeutic target for preventing GC progression.
other	34775268	hsa-mir-195	Salivary Gland Pleomorphic Adenoma	Furthermore, T042819 was significantly upregulated in SGPA, which may upregulate PLAG1 by sponging has-miR195-5p.
target gene	34774989	hsa-mir-130b	Non-alcoholic Fatty Liver Disease	LncRNA HOTAIR regulates the lipid accumulation in non-alcoholic fatty liver disease via miR-130b-3p/ROCK1 axis.
genetics_overexpression_suppress	34774846	hsa-mir-146a	Intestinal Diseases	Finally, we observed that miR-146a-5p overexpression inhibits autophagy and attenuates intestinal I/R injury via the PRKAA/mTOR pathway by targeting TXNIP in vivo.
transcription factor target	34774740	hsa-mir-702	Sepsis	3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR
transcription factor target	34774740	hsa-mir-702	Myocarditis	3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR
transcription factor target	34774740	hsa-mir-702	Susac Syndrome	3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR
transcription factor target	34774740	hsa-mir-702	Cardiomyopathies	3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR
other	34774537	hsa-mir-155	Lymphoma, T-Cell, Cutaneous	Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression.
other	34774537	hsa-mir-130	Lymphoma, T-Cell, Cutaneous	Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression.
other	34774537	hsa-mir-21	Lymphoma, T-Cell, Cutaneous	Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression.
other	34774515	hsa-mir-451	Breast Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774515	hsa-mir-375	Skin Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774515	hsa-mir-451	Skin Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774515	hsa-mir-144	Skin Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774515	hsa-mir-375	Breast Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774515	hsa-mir-144	Breast Neoplasms	In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer).
other	34774083	hsa-mir-515	Osteosarcoma	Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis.
genetics_knock down_promote	34774079	hsa-mir-187	Ovarian Neoplasms	Gain- and loss-of-function studies of circ_0000745, microRNA (miR)
genetics_knock down_promote	34774078	hsa-mir-1297	Uterine Cervical Neoplasms	Moreover, miR-1297 inhibition and RCN2 overexpression could counteract the inhibitory effects of DUXAP8 knockdown on the malignant phenotypes of CC cells. CONCLUSIONS: DUXAP8 promotes malignant behaviors in CC cells via regulating miR-1297/RCN2 axis.
lncRNA target	34774019	hsa-mir-1915	Carcinoma, Non-Small-Cell Lung	3p significantly suppressed migration, invasion and epithelial-mesenchymal transition (EMT) in NSCLC cells.
lncRNA target	34773997	hsa-mir-17	Congenital central hypoventilation syndrome	The axis of Stat5a/Dnmt3a/miR5p/Cdkn1a potentially provides a treatment target for cMPNs.
lncRNA target	34773997	hsa-mir-17	Charcot-Marie-Tooth disease type 1B	The axis of Stat5a/Dnmt3a/miR5p/Cdkn1a potentially provides a treatment target for cMPNs.
lncRNA target	34773846	hsa-mir-155	Pulmonary Disease, Chronic Obstructive	In this study, we used an established PM2.5-aggravated COPD rat model in vivo to evaluate the protective effect of ECC-BYF, and focused on its antioxidative role in PM2.5-stimulated bronchial epithelial cells via regulating microRNA (miR)-155/ forkhead box class O3a (FOXO3a) pathway. In conclusion, ECC-BYF can protect pre-existing COPD against PM2.5 contamination by exerting a profound antioxidative influence via regulating miR-155/FOXO3a signaling.
lncRNA target	34773593	hsa-mir-134	Parkinson Disease	JHDM1D-AS1 protected against MPP -induced neuron injury via miR5p/PIK3R3 axis, suggesting the potential involvement of this axis in PD process.
genetics_knock down_promote	34773443	hsa-mir-346	Colorectal Neoplasms	The present study indicated that miR-346 knockdown repressed cell growth in CRC cells by upregulating LHX6, and this was associated with inactivation of the Akt/mTOR pathway.
circulation_biomarker_diagnosis_ns	34773365	hsa-mir-146a	Tuberculosis	Subsequently, we discovered that miR-146a-5p, which may target UBE2L6, is reduced in peripheral blood mononuclear cells (PBMC) and plasma of TB, and it also had certain diagnostic efficiency(AUC=0.791). In brief, we demonstrated that UBE2L6 as well as miR-146a-5p is a potential biomarker for TB and UBE2L6,which may also plays important role in TB by, at least, modulating Mtb-infected macrophage apoptosis.
lncRNA target	34772911	hsa-mir-22	Glioblastoma	3p inhibitor offsets the HNF1A-AS1 silencing induced suppression in malignant behaviors of GBM cells.
lncRNA target	34772428	hsa-mir-497	Carcinoma, Non-Small-Cell Lung	CONCLUSION: By targeting CDCA4, miR
lncRNA target	34772311	hsa-mir-27b	Obesity	OBJECTIVE: To investigate the effect of liraglutide on the browning of white fat and the suppression of obesity via regulating microRNA (miR)-27b in vivo and in vitro.
lncRNA target	34771727	hsa-mir-21	Colorectal Neoplasms	The results demonstrate that miR-21 can induce CRC or colitis-associated cancer (CAC) in ImiR-21 through the PI3K/AKT, PDCD4/TNF-alpha, and IL-6/STAT3 signaling network. Hence, our findings indicate that miR-21 is critical for the development of CRC/CAC via the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks.
lncRNA target	34771727	hsa-mir-21	Colitis-Associated Neoplasms	The results demonstrate that miR-21 can induce CRC or colitis-associated cancer (CAC) in ImiR-21 through the PI3K/AKT, PDCD4/TNF-alpha, and IL-6/STAT3 signaling network. Hence, our findings indicate that miR-21 is critical for the development of CRC/CAC via the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks.
lncRNA target	34771465	hsa-mir-100	Melanoma	5p and 125b-5p are potential markers of response to PD-1 inhibitors, and further evaluation of these microRNA-mRNA interactions may yield further insight into melanoma resistance to PD-1 inhibitors.
other	34771422	hsa-mir-21	Multiple Myeloma	5p are differently expressed between MM patients and healthy controls.
circulation_biomarker_diagnosis_ns	34771422	hsa-mir-29b	Multiple Myeloma	Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR5p correlated with thoracic lesions.
other	34771422	hsa-mir-29c	Multiple Myeloma	Additionally, miR-29c-3p was decreased in patients with osteolytic lesions compared with patients without bone disease.
other	34771422	hsa-mir-20a	Multiple Myeloma	5p are differently expressed between MM patients and healthy controls.
other	34771422	hsa-mir-16	Multiple Myeloma	5p are differently expressed between MM patients and healthy controls.
circulation_biomarker_diagnosis_ns	34771422	hsa-mir-195	Multiple Myeloma	Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR5p correlated with thoracic lesions.
lncRNA target	34769388	hsa-mir-204	Squamous Cell Carcinoma of Head and Neck	Conclusions: This study identifies differentially expressed miRs in stromal fibroblasts of OSCC lesions compared with normal oral mucosa and it reveals that one of the significantly downregulated miRs in CAF, miR-204, has a tumor-suppressive function through inhibition of fibroblast migration by modulating the expression of several different molecules in addition to directly targeting ITGA11.
other	34769292	hsa-mir-132	Laron Syndrome	3p levels, with ensuing reduction in SIRT1 gene expression.
exosome	34769265	hsa-mir-122	Pulmonary Disease, Chronic Obstructive	Of these, miR5p was three- or five-fold downregulated among the lung-tissue-derived exosomes of COPD patients as compared to healthy non-smokers and smokers, respectively.
exosome	34769265	hsa-mir-122	Pulmonary Fibrosis	Of these, miR5p was three- or five-fold downregulated among the lung-tissue-derived exosomes of COPD patients as compared to healthy non-smokers and smokers, respectively.
other	34769160	hsa-mir-1	Mouth Neoplasms	NUMB-MCT1/MCT4 regulatory cascade is present in oral carcinoma.
lncRNA target	34769029	hsa-mir-363	Cerebral Hemorrhage	The expression of miRNA363-5p was inhibited and the expression of P2RX4 was upregulated in sciatic nerve injury. This study suggests that a double-negative feedback loop between miRNA363-5p and P2RX4 contributes to the dedifferentiation and migration of Schwann cells after nerve injury.
lncRNA target	34768991	hsa-mir-877	Arthritis, Rheumatoid	The possible target genes of miR
lncRNA target	34768968	hsa-mir-29b	Rubella Syndrome, Congenital	During this process, epithelial-mesenchymal transition (EMT) plays an important role in dysregulated remodeling and both microRNA (miR)-29b and heat shock protein 47 (HSP47) may be engaged in the pathophysiology of CRS. These results suggested the importance of miR-29b and HSP47 in pathologic tissue remodeling progression in CRS.
transcription factor target	34768749	hsa-mir-541	Spinal muscular atrophy with respiratory distress 1	5p in alveolar epithelial cells, promoting EMT and contributing to RIPF by targeting Slug.
transcription factor target	34768749	hsa-mir-541	Radiation-Induced Pulmonary Fibrosis	5p in alveolar epithelial cells, promoting EMT and contributing to RIPF by targeting Slug.
lncRNA target	34768615	hsa-mir-34a	Lupus Erythematosus, Systemic	Enrichment analysis confirmed the implication of MIR34A in the SLE pathway by targeting several genes related to SLE etiopathology.
other	34768564	hsa-mir-451a	Hemolysis	To test the clinical usefulness of miR-451a as a biomarker of hemolytic diseases, we analyzed miRNAs of samples from 10 normal subjects, 30 leftover samples in the clinical laboratory, and 20 samples from patients with hemolytic diseases.
lncRNA target	34768379	hsa-mir-34b	Leptomeningeal Metastasis	Among 30 miRNAs identified for LM-specific biomarkers via a Prediction Analysis of Microarrays, miR5p and miR-34b-3p were confirmed in both the discovery and validation samples (n = 23).
lncRNA target	34768379	hsa-mir-335	Leptomeningeal Metastasis	Among 30 miRNAs identified for LM-specific biomarkers via a Prediction Analysis of Microarrays, miR5p and miR-34b-3p were confirmed in both the discovery and validation samples (n = 23).
exosome	34768151	hsa-mir-6924	Osteolysis	In brief, our study demonstrates that BMMSC(Scx)-exos or miR5p could serve as a potential therapy for the treatment of osteolysis during tendon-bone healing and improve the outcome.
exosome	34768001	hsa-mir-146a	Depression	Collectively, these results indicate that miR-146a-5p can function as a critical factor regulating neurogenesis under conditions of pathological processes resulting from depression and suggest that microglial exosomes generate new crosstalk channels between glial cells and neurons.
circulation_biomarker_diagnosis_ns	34767935	hsa-mir-150	Leukemia	miR150 expression in leukemic cell lines and in blood collected from leukemia patients with diverse outcomes was evaluated by quantitative RT-PCR. Levels of circulating miR150 were found to be decreased after radiation in leukemia patients and exhibited an inverse correlation with recurrence.
genetics_knock down_promote	34767926	hsa-mir-210	Stomach Neoplasms	Gain- and loss-of-function studies demonstrate that miR-210 and MIR210HG synergistically promote the migration and invasion of GC cells in vitro.
transcription factor target	34767797	hsa-mir-125a	Pulmonary Fibrosis	Our findings suggest that ghrelin attenuates TGF-beta1-induced pulmonary fibrosis via the miR-125a-5p/KLF13 axis, which supports ghrelin as a new therapeutic agent against pulmonary fibrosis by antagonizing the TGF-beta1 signaling pathway.
lncRNA target	34767742	hsa-mir-378a	Nasopharyngeal Carcinoma	Moreover, miR-378a-3p plays a suppressive role in NPC cells.
target gene	34767738	hsa-mir-141	Uterine Cervical Neoplasms	miR-141-5p Affects the Cell Proliferation and Apoptosis by Targeting BTG1 in Cervical Cancer.
other	34767733	hsa-mir-199	Stomach Neoplasms	A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors.
other	34767733	hsa-mir-103a	Stomach Neoplasms	A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors.
other	34767733	hsa-mir-200b	Stomach Neoplasms	A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors.
genetics_knock down_promote	34767727	hsa-mir-124	Adenocarcinoma of Lung	3p depletion reversed the suppression of PTPRG-AS1 silence on LUAD cell behaviors, but then CCND1 knockdown countervailed the promoting influence of downregulated miR
lncRNA target	34767671	hsa-mir-145	Aortic Dissection	CONCLUSION: Our results confirmed that mechanical stretch-induced phenotypic transformation of VSMCs to promote AD via upregulation of KLF4; this mechanism was regulated by miR-145, which directly modulated KLF4 expression and VSMC differentiation.
lncRNA target	34766707	hsa-mir-455	Necrobiotic Disorders	These data suggest that microcrystalline silica can induce significant inflammation and pyroptosis in human primary AEC through NLRP3 inflammasome pathway and NF-kappaB signaling pathway at both the gene and protein levels, and the possible mechanism could be miR3p mediated ceRNA hypothesis.
lncRNA target	34766707	hsa-mir-455	Inflammation	These data suggest that microcrystalline silica can induce significant inflammation and pyroptosis in human primary AEC through NLRP3 inflammasome pathway and NF-kappaB signaling pathway at both the gene and protein levels, and the possible mechanism could be miR3p mediated ceRNA hypothesis.
lncRNA target	34766670	hsa-mir-101	Squamous Cell Carcinoma of Head and Neck	These findings demonstrated the oncogenic role of SNHG6, which promotes OSCC progression by regulating the expression of EZH2 through its interaction with miR
circulation_biomarker_diagnosis_up	34766525	hsa-mir-29a	Myopia	METHODS: The miR-29a expression level was detected in the aqueous humor and peripheral blood plasma of 21 high myopic patients and eight cataract control patients using quantitative polymerase chain reaction.
genetics_overexpression_promote	34766472	hsa-mir-1286	Arthritis, Rheumatoid	Overexpression of BZRAP1-AS1 reduced the miR-1286 expression which in turn increased the COL5A2 expression, thereby relieving the excessive proliferation and limited apoptosis in RA-HFLS.
genetics_overexpression_promote	34765599	hsa-mir-512	Nasopharyngeal Carcinoma	Conclusion: Circ_0000215 is overexpressed in NPC and exerts oncogenic effects in NPC through regulating miR
lncRNA target	34765550	hsa-mir-299	Carcinoma, Hepatocellular	Mechanically, FAM99A interacted with EIF4B to inhibit gp130 and gp80 translation, which then interacted with miR5p to upregulate SOCS3, causing the JAK2 pathway to inhibit STAT3 phosphorylation, so that JAK2/STAT3 was blocked in HCC cells.
genetics_overexpression_promote	34765296	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	Our results showed that lncRNA NR2F2-AS1, c-Met, BVR and ATF-2 were overexpressed while miR
other	34765025	hsa-mir-335	Ischemic Stroke	The expression levels of miR-335 and miR-495 in the IS group were significantly lower compared with the control group (P<0.05).
other	34765025	hsa-mir-495	Ischemic Stroke	The expression levels of miR-335 and miR-495 in the IS group were significantly lower compared with the control group (P<0.05).
transcription factor target	34765019	hsa-mir-519d	Osteoarthritis, Post-Traumatic	In conclusion, reduction of miR-519d-3p in the synovium and SF resulted in the upregulation of VEGF in patients with PTOA, and miR-519d-3p may be a potential therapeutic target of PTOA.
circulation_biomarker_diagnosis_ns	34765018	hsa-mir-23a	Diabetic Retinopathy	The elevated VEGF expression in the blood and tears of patients with DR may be related to the reduced miRNA-23a expression.
genetics_overexpression_suppress	34765013	hsa-mir-139	Breast Neoplasms	5p expression in BC cells was obviously low, while MEX3A was significantly overexpressed.
transcription factor target	34765002	hsa-mir-1	Ataxia Neuropathy Spectrum	In conclusion, YQHX alleviates H/R-induced cardiomyocyte apoptosis by inhibiting miR-1 expression, suggesting the potential of YQHX in preventing MIRI.
target gene	34764975	hsa-mir-25	Stomach Neoplasms	miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2.
exosome	34764819	hsa-mir-326	Osteoarthritis	CONCLUSION: BMSC-Exos can deliver miR-326 to chondrocytes and cartilage and improve OA by targeting HDAC3 and STAT1//NF-kappaB p65 to inhibit pyroptosis of chondrocytes and cartilage.
exosome	34764819	hsa-mir-326	Cartilage Diseases	CONCLUSION: BMSC-Exos can deliver miR-326 to chondrocytes and cartilage and improve OA by targeting HDAC3 and STAT1//NF-kappaB p65 to inhibit pyroptosis of chondrocytes and cartilage.
genetics_knock down_promote	34764804	hsa-mir-590	Angelman Syndrome	Knockdown of ZEB1-AS1 alleviates ox-LDL-induced endothelial cell injury by regulating the miR
lncRNA target	34764801	hsa-mir-205	Acute Kidney Injury	Resveratrol alleviates sepsis-induced acute kidney injury by deactivating the lncRNA MALAT1/MiR-205 axis.
lncRNA target	34764801	hsa-mir-205	Sepsis	Resveratrol alleviates sepsis-induced acute kidney injury by deactivating the lncRNA MALAT1/MiR-205 axis.
circulation_biomarker_diagnosis_down	34764785	hsa-mir-345	Leukemia, Myeloid, Acute	5p was a target of circNPM1 and was downregulated in AML serum and cells.
target gene	34764730	hsa-mir-4425	Breast Neoplasms	Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation.
lncRNA target	34764698	hsa-mir-940	Adenocarcinoma of Lung	3p were determined via RT-qPCR in LUAD tissues and cells.
circulation_biomarker_diagnosis_up	34764695	hsa-mir-122	Colorectal Neoplasms	5p in the serum of patients with colorectal cancer correlates with the severity of myelosuppression caused by chemotherapy, and miR
circulation_biomarker_diagnosis_up	34764695	hsa-mir-122	Lung Neoplasms	5p in the serum of patients with colorectal cancer correlates with the severity of myelosuppression caused by chemotherapy, and miR
genetics_GWAS	34763855	hsa-mir-169	Dehydration	Overall, our findings implied that the miR169n-NF-YA8 regulatory module could serve as a potential target for genetic improvement of drought resistance in B.
exosome	34763521	hsa-mir-23-2	Myocardial Reperfusion Injury	CONCLUSIONS: We demonstrate for the first time that MI/R causes significant adipocyte ER stress and endocrine dysfunction by releasing miR27-24 cluster-enriched small extracellular vesicle.
genetics_overexpression_promote	34763405	hsa-mir-296	Squamous Cell Carcinoma of Head and Neck	5p, cell viability, clone formation red number, migration rate, number of invasive cells, S phase cell ratio, glu consumption, alpha-KG production, ATP concentration, cyclinD1, GLS1 and TAGLN2 proteins in OSCC cells after overexpression of miR
other	34763233	hsa-mir-92a	Melanoma	Finally, using bioinformatics analysis, we predicted that PAX8-AS1/Z83843.1-miR-92a-3p-IFIT2 axis might play crucial roles in the development and progression of SKCM.
other	34763043	hsa-mir-216b	Diabetes Mellitus, Type 2	5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05).
other	34763043	hsa-mir-9	Diabetes Mellitus, Type 2	5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05).
other	34763043	hsa-mir-150	Diabetes Mellitus, Type 2	5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05).
lncRNA target	34762771	hsa-mir-29c	gastric adenocarcinoma	CONCLUSION: This finding confirmed that lncRNA TUG1 acts as a ceRNA for miR-29c-3p to promote tumor progression and angiogenesis by upregulating VEGFA, indicating TUG1 as a therapeutic target in STAD management.
circRNA target	34762494	hsa-mir-548m	Glioma	Conclusions: All these results demonstrate that circ-GLIS3 accelerates TMZ-R glioma progression through the miR-548m/MED31 axis.
other	34762068	hsa-mir-2052	Breast Neoplasms	BACKGROUND: Published studies based on pharmacokinetics have explored the relationship between the lncRNA MIR2052HG and the prognosis of breast cancer (BC) resistance and recurrence.
genetics_GWAS	34762068	hsa-mir-4456	Breast Neoplasms	CONCLUSION: Our study showed that the MIR2052HG gene polymorphism may be related to BC susceptibility, and the MIR2052HG rs34841297 A/- genotype may probably affect the proliferation, invasion and migration of BC cells by modulating the interactions with of miR-4456.
genetics_GWAS	34761964	hsa-mir-938	Hirschsprung Disease	Aim: To explore the association between miR-938rs2505901 T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. Conclusion: Our study indicated that miR-938rs2505901 T>C polymorphism is significantly associated with HSCR risk in Chinese children.
other	34761722	hsa-mir-30	psoriasis 1	There was a negative correlation between miR5p and MALAT-1 (or S100A7) expression in psoriatic lesion tissues.
lncRNA target	34761662	hsa-mir-224	Rhinitis, Allergic	It proves that miR-224 could be a novel potential therapeutic target for AR.
genetics_overexpression_suppress	34761629	hsa-mir-204	Pancreatic Carcinoma	Overexpression of microRNA
circulation_biomarker_prognosis_ns	34761617	hsa-mir-410	Carcinoma, Renal Cell	MiR-410 in the tissues and serum of patients with CCRCC was quantified, and the diagnostic value of miR-410 in CCRCC and the relationship between miR-410 and prognosis of patients with CCRCC were analyzed.
lncRNA target	34761614	hsa-mir-188	Lymphoma, Natural   Killer/T-Cell	5p suppressed tumor progression in NKTCL by regulating XRCC5.
lncRNA target	34761606	hsa-mir-217	Carcinoma, Hepatocellular	CONCLUSIONS: LINC00355 is upregulated in HCC specimens, LINC00355 triggers proliferative rate and inhibits apoptosis in HCC cells by negatively regulating miR5p and activating the Wnt/beta-catenin signaling.
genetics_knock down_promote	34761592	hsa-mir-138	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ-PRMT5 knockdown increased DDP sensitivity and immune response of NSCLC cells by regulating miR
exosome	34761590	hsa-mir-126	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Taken together, the key finding of the study indicated that over-expressed BMSCs-derived exosomal miR
genetics_overexpression_promote	34761583	hsa-mir-99a	Uterine Cervical Neoplasms	To further verify the correlation of miR-99a with IGF1R in cervical cancer, we co-transfected miR-99a and IGF1R overexpression vectors into the cells and found that compared with CCCs transfected with miR-99a overexpression vectors alone, the expression of IGF1R in the co-transfection group increased, while the expression of miR-99a did not change significantly.
genetics_overexpression_promote	34761581	hsa-mir-34a	Uterine Cervical Neoplasms	Co-transfection assays showed that overexpression of CDC25A reversed the inhibition of miR-34a-5p on CC growth and migration.
lncRNA target	34761351	hsa-mir-383	Breast Neoplasms	5p restoration, as a tumor-suppressive miR, with taxol therapy in suppressing MDA-MB-231 breast cancer development.
other	34761332	hsa-mir-223	Brain Injuries, Traumatic	3p and other inflammatory responsive miRNAs may play a key role in sex-specific neuroinflammatory response following TBI.
transcription factor target	34761190	hsa-mir-1307	Liver Neoplasms	miR-1307 is highly expressed in liver cancer and inhibits methyltransferase protein8.
lncRNA target	34761116	hsa-mir-141	Mesothelioma, Malignant	MALAT1 can be used as a competitive endogenous RNA (ceRNA) to regulate the YAP1-Hippo signaling pathway through miR
genetics_overexpression_suppress	34761115	hsa-mir-150	Angelman Syndrome	5p weakened the ox-LDL-induced increase of viability and migration abilities and blocked cell cycle in ASMCs, but overexpressed STAT1 blocked the effect of the miR
transcription factor target	34761108	hsa-mir-378a	Glioma	This study confirmed that miR-378a-3p promoted the sensitivity of glioma cells to CDDP in glioma patients via targeting IGF1R to increase the therapeutic effect during chemotherapy.
other	34761005	hsa-mir-27a	Retinal Detachment	Also, our data emphasize the prominent role of miR-27a/FOXO1 axis in modulating ROS accumulation and cell death in RPE cell model under oxidative stress and influencing the retinal function in the LED-induced RD rat model.
circulation_biomarker_diagnosis_up	34760951	hsa-mir-92a	Refractory Angina	Circulating miR-92a increased significantly in ECP [5.1 (4.2-6.4) to 5.9 (4.8-6.4), p < 0.001] and sham [5.2 (4.1-9.4) to 5.6 (4.8-6.3), p = 0.008] post-intervention.
other	34760693	hsa-mir-182	Carcinoma, Renal Cell	5p, and PAX3.
other	34760693	hsa-mir-182	von Hippel-Lindau Disease	5p, and PAX3.
other	34760693	hsa-mir-183	Carcinoma, Renal Cell	5p, and PAX3.
other	34760693	hsa-mir-183	von Hippel-Lindau Disease	5p, and PAX3.
other	34760337	hsa-mir-520h	Prostatic Neoplasms	HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer.
other	34759745	hsa-mir-378	Ovarian Neoplasms	CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378.
other	34759299	hsa-mir-7	Mitochondrial Diseases	Consistently, electron microscopy showed that miRNA-7 Tg hearts had disorganized rounded mitochondria that was associated with mitochondrial dysfunction.
other	34759299	hsa-mir-7	Dmd-Associated Dilated Cardiomyopathy	These findings show that expression of miRNA-7 in the cardiomyocytes results in cardiac dilation instead of adaptive hypertrophic response during aging or to TAC providing insights on yet to be understood role of miRNA-7 in cardiac function.
circulation_biomarker_diagnosis_up	34758804	hsa-mir-155	Pneumonia	METHODS: GAS5 and miR-155 levels in plasma samples from pneumonia patients and controls were detected using RT-qPCR.
lncRNA target	34758714	hsa-mir-4295	Stomach Neoplasms	Our study suggested that miR-4295 might be a potential therapeutic target for gastric cancer.
circRNA target	34758534	hsa-mir-873	Thyroid Neoplasms	Conclusion: circ_0023990 was highly expressed in thyroid cancer tissues and cell lines, and it may promote the radiotherapy resistance of thyroid cancer cells in vivo through regulating miR
genetics_overexpression_suppress	34758406	hsa-mir-4732	Carcinoma, Non-Small-Cell Lung	In addition, the overexpression of miR
other	34758342	hsa-mir-21	Neuralgia	Patient biomaterial revealed different systemic expression patterns of miR5p, with higher expression in SFN and lower expression in NL.
lncRNA target	34758237	hsa-mir-125b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	METHODS: Real-time fluorescent quantitative PCR was utilized to test circPVT1 and miR-125b in ALL samples and ALL cell systems. CONCLUSIONS: CircPVT2 can promote ALL cell proliferation and invading through miR-125b modulation of NF-kappaB, which would be one new potential target for ALL therapy.
genetics_overexpression_promote	34758200	hsa-mir-107	Glioma	Overexpression of miR-107 reduced proliferation, migration and invasion, and augmented apoptosis of glioma cells, and it reduced activity of the Wnt/beta-catenin pathway.
lncRNA target	34757838	hsa-mir-376b	Porcine Reproductive and Respiratory Syndrome	In the present study, we demonstrated that a host microRNA, miR-376b-3p, was upregulated by PRRSV infection through the viral components, nsp4 and nsp11, and that miR-376b-3p can directly target tripartite motif-containing 22 (TRIM22) to impair its anti-PRRSV activity, thus facilitating the replication of PRRSV.
other	34757596	hsa-mir-539	Cardiomyopathies	METHODS: The model of septic cardiomyopathy was constructed with H9c2 cells induced by lipopolysaccharide (LPS), and the expression of miR5p was detected by qRT-PCR assay.
transcription factor target	34757596	hsa-mir-539	Sepsis	5p may be a potential new target for the treatment of LPS-induced sepsis.
lncRNA target	34756071	hsa-mir-22	Encephalitis, Japanese	Japanese encephalitis virus (JEV) NS1', a larger NS1-related protein, is known to inhibit the mitochondrial antiviral signaling (MAVS)-mediated IFN-beta induction by increasing the binding of transcription factors (CREB and c-Rel) to the microRNA 22 (miRNA-22) promoter.
lncRNA target	34756016	hsa-mir-155	Acute Lung Injury	We report here a unique design of a functional nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer-entrapped gold nanoparticles (Au DENPs) to co-deliver dexamethasone (Dex) and a microRNA-155 inhibitor (miR-155i) for combination chemotherapy and gene therapy of ALI. The integration of Dex and miR-155i within one nanoformulation enables superior downregulation of pro-inflammatory cytokines for successful repair of damaged lung tissues in an ALI model, as demonstrated by histological examinations and pro-inflammatory cytokine downregulation in ALI lesion at the gene and protein levels.
other	34755842	hsa-mir-133a	COVID-19	Whilst RNAemia, age and troponin were better predictors of mortality, miR-133a and miR-122 showed superior classification performance for severity.
other	34755842	hsa-mir-122	COVID-19	Whilst RNAemia, age and troponin were better predictors of mortality, miR-133a and miR-122 showed superior classification performance for severity.
genetics_overexpression_promote	34755673	hsa-mir-671	Osteosarcoma	5p overexpression obviously reversed this effect (P < 0.05).
other	34755560	hsa-mir-130b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: DHA can block ILtriggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways.
genetics_knock down_promote	34755307	hsa-mir-132	Urinary Bladder Neoplasms	3p or KCNJ12 knockdown.
other	34755149	hsa-mir-19a	Neuralgia	Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
other	34755149	hsa-mir-19b	Spinal Cord Injuries	Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
other	34755149	hsa-mir-19	Neuralgia	We selected homo sapiens (hsa)-miR-19a-3p and hsa-miR-19b-3p for additional analysis based on p-value, fold change, and their known role as regulators of neuropathic pain and neuroinflammation. Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
other	34755149	hsa-mir-19b	Neuralgia	Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
other	34755149	hsa-mir-19	Spinal Cord Injuries	We selected homo sapiens (hsa)-miR-19a-3p and hsa-miR-19b-3p for additional analysis based on p-value, fold change, and their known role as regulators of neuropathic pain and neuroinflammation. Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
other	34755149	hsa-mir-19a	Spinal Cord Injuries	Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain.
circRNA target	34754888	hsa-mir-496	Osteoporosis	CONCLUSION: Our study demonstrated that RUNX3 promoted osteogenic differentiation via regulating the hsa_circ_0005752/miR-496/MDM2 axis and thus provided a new therapeutic strategy for osteoporosis.
other	34754625	hsa-mir-155	Reperfusion Injury, Renal Ischemia	Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI.
other	34754625	hsa-mir-146a	Reperfusion Injury, Renal Ischemia	Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI.
other	34754625	hsa-mir-25	Reperfusion Injury, Renal Ischemia	Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI.
other	34754623	hsa-mir-708	Lung Neoplasms	The good screening capability and reliability of miR5p as a lung cancer marker were confirmed by AUC values and gene expression profiling of external datasets, and experimental literature.
other	34754230	hsa-mir-23a	Pre-Eclampsia	LncRNA (LINCO2532 and SLCO4A1-AS1) and DYNLRB1 were downregulated and the expression of miR23a-5p was upregulated in PE patients compared with healthy controls.
transcription factor target	34754027	hsa-mir-7515	Sarcoma, Ewing	Interestingly, SCE cells treated with miR-7515 mimic showed increased VEGFA, VEGFR2, PECAM, and Tie2 expression. Our data showed that TM cells may communicate with SCE cells via exomiRs and that miR-7515 may be important for SCE cell reprogramming.
lncRNA target	34753831	hsa-mir-214	Arthritis, Rheumatoid	In summary, our study shows that tocilizumab suppresses RA-FLS inflammation by regulating the MIR31HG-miR
lncRNA target	34753831	hsa-mir-1	Arthritis, Rheumatoid	In summary, our study shows that tocilizumab suppresses RA-FLS inflammation by regulating the MIR31HG-miR
genetics_knock down_suppress	34753799	hsa-mir-200c	Diabetes Mellitus, Type 2	Finally, LNA knockdown of miR-200c increased glucose-stimulated insulin secretion in islets from T2D donors approximately threefold.
genetics_knock down_suppress	34753799	hsa-mir-200	Diabetes Mellitus, Type 2	Finally, LNA knockdown of miR-200c increased glucose-stimulated insulin secretion in islets from T2D donors approximately threefold.
other	34753773	hsa-mir-122	Colorectal Neoplasms	Across multiple colorectal cancer liver metastasis models, treatment with Gal-LCP miR-122 treatment effectively prevented colorectal cancer liver metastasis and prolonged survival.
lncRNA target	34753486	hsa-mir-934	Carcinoma, Non-Small-Cell Lung	Furthermore, circUSP7 inhibits CD8(+) T cell function by upregulating the expression of Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) via sponging miR-934.
circRNA target	34753401	hsa-mir-193b	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Our findings proposed a novel model in which circ_0000745 promoted cell proliferation and curbed cell apoptosis via upregulating NOTCH1 through serving as a miR-193b-3p sponge in T-ALL.
circRNA target	34753398	hsa-mir-497	Norrie disease	5p/NFAT5 axis in HK-2 cells in vitro, providing a possible therapy target for DN.
lncRNA target	34753396	hsa-mir-150	Colorectal Neoplasms	We further demonstrated that the effects of LINC00857 in CRC cells were mediated through miR
genetics_knock down_promote	34753394	hsa-mir-22	Osteosarcoma	3p on OS progression and promotion of Wnt/beta-catenin were reversed by simultaneous knockdown of TCF7L2.
circulation_biomarker_diagnosis_ns	34753389	hsa-mir-223	Fractures, Bone	The research explored the level of serum miR
other	34753389	hsa-mir-223	Radius Fractures	3p was significantly elevated over time in patients with intra-articular fracture and hand fracture compared with healthy individuals.
other	34753389	hsa-mir-223	Intra-Articular Fractures	3p was significantly elevated over time in patients with intra-articular fracture and hand fracture compared with healthy individuals.
lncRNA target	34753384	hsa-mir-381	Colorectal Neoplasms	In summary, our data revealed that the miR-381/SPIN1 axis greatly contributes to CRC tumorigenesis by orchestrating the Wnt/beta-catenin pathway, thereby representing actionable therapeutic targets for colorectal cancer patients.
genetics_overexpression_promote	34753136	hsa-mir-1	Osteoarthritis	Further functional experiments demonstrated that overexpressing miR
genetics_overexpression_promote	34753133	hsa-mir-142	Colonic Neoplasms	Overexpressing miR
other	34753061	hsa-mir-155	Urinary Bladder Neoplasms	5p/WEE1 axis in GEM resistant BC cells, providing a novel therapeutic strategy for BC.
target gene	34752967	hsa-mir-205	Carcinoma, Non-Small-Cell Lung	He-Chan Pian inhibits the metastasis of non-small cell lung cancer via the miR-205-5p-mediated regulation of the GREM1/Rap1 signaling pathway.
circulation_biomarker_prognosis_up	34752733	hsa-mir-222	Breast Neoplasms	The receiver operating characteristic curves plotted for serum p27 and miR-222 helped in significantly differentiating between breast cancer patients and controls but could not discriminate between those with stage II and stage III cancer.
lncRNA target	34751998	hsa-mir-125a	Developmental Disabilities	Mechanistically, we confirmed that miR-125a-5p disturbed the mitochondrial function by targeting Rbm38 and activating the p53 damage response pathway, and induced a developmental delay in a p21-dependent manner.
other	34751973	hsa-mir-488	Spinal Cord Injuries	Our research provides a better understanding of the mechanism of circPrkcsh in SCI and demonstrates that the circPrkcsh/miR-488/Mekk1 axis is a promising regulatory method for the treatment of SCI.
genetics_GWAS	34751841	hsa-mir-200a	Stomach Neoplasms	Although ontogenetic or tumor-suppressive effects of miRNA-200a-3p have been demonstrated, the exact mechanism underlying GC is not clear.
other	34751517	hsa-mir-4516	Triple Negative Breast Neoplasms	RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24).
other	34751517	hsa-mir-125b	Triple Negative Breast Neoplasms	RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24).
other	34751517	hsa-mir-210	Triple Negative Breast Neoplasms	RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24).
other	34751517	hsa-mir-718	Triple Negative Breast Neoplasms	RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24).
lncRNA target	34751414	hsa-mir-34a	Cataract, Diabetic	In conclusion, XIST promoted cell proliferation, migration and invasion, and inhibited apoptosis, through the miR34a/SMAD2 axis in DC.
lncRNA target	34751282	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	As the concept of design, chitosan-derived nanocarrier DCAFP, capable of persuading mitochondrial dysfunction, is demonstrated to convey gefitinib (GFT) and miR21 inhibitor (anti-miR21) to form DGA nanoparticles.
transcription factor target	34751119	hsa-mir-582	Parkinson Disease	CONCLUSION: Our results indicated that miR5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1.
transcription factor target	34751119	hsa-mir-582	Hypoxia-Ischemia, Brain	CONCLUSION: Our results indicated that miR5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1.
genetics_overexpression_promote	34751080	hsa-mir-29a	Osteoarthritis	RESULTS: CircCTNNA1 was downregulated in OA, while miR-29a was overexpressed in OA. CONCLUSIONS: CircCTNNA1 is downregulated in OA, and its overexpression suppresses synoviocyte apoptosis via sponging miR-29a.
transcription factor target	34750830	hsa-mir-630	Atherosclerosis	In addition, miR-630 can also target EZH2 to modulate the transcription of TIMP2 and to influence the migration of MASMCs.
genetics_knock down_promote	34750680	hsa-mir-9	Optic atrophy 1 and deafness	5p knockdown promotes HG-induced osteogenic differentiation BMSCs in vitro and mitigates the DOP condition of rats in vivo by targeting DDX17.
exosome	34750610	hsa-mir-150	Acute Lung Injury	CONCLUSIONS: Exosomal miR-150 attenuates lipopolysaccharide-induced ALI through the MAPK pathway.
other	34750486	hsa-mir-16	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-193b	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-34a	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-192	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-7	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-26b	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-215	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750486	hsa-mir-92a	COVID-19	Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.
other	34750395	hsa-mir-571	Liver Cirrhosis	miR-571, Notch3 and Jagged1 are up-regulated in patients with liver fibrosis and is associated with the progression of liver fibrosis.
genetics_overexpression_promote	34750354	hsa-mir-543	Lymphoma, B-Cell	BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression.
genetics_overexpression_promote	34750354	hsa-mir-494	Lymphoma, B-Cell	BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression.
genetics_overexpression_promote	34750354	hsa-mir-495	Lymphoma, B-Cell	BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression.
lncRNA target	34750351	hsa-mir-185	Squamous Cell Carcinoma of Head and Neck	In conclusion, our findings firstly confirmed the carcinogenic effect of circ_0058106 in promoting HSCC cells tumorigenesis, metastasis, invasion and EMT process by regulating Wnt2b/-catenin/c-Myc pathway through sponging miR
lncRNA target	34749775	hsa-mir-378a	Carcinoma, Hepatocellular	CONCLUSION: Our study indicates a novel DNMT1/miR-378a-3p/TRAF1/NF-kappaB positive feedback loop in HCC cells, which may become a potential therapeutic target for HCC.
other	34749766	hsa-mir-7161	Stomach Neoplasms	3p-mediated translational repression of SPZ1, thus contributing to gastric cancer progression.
genetics_overexpression_suppress	34749662	hsa-mir-216a	Asthma	RESULTS: TUG1 and SMURF2 were overexpressed and miR-216a-3p was downregulated in childhood asthma patients and PDGF-BB-stimulated HASMCs. CONCLUSION: TUG1 downregulation inhibited PDGF-BB-induced HASMC proliferation and migration by regulating miR-216a-3p/SMURF2 axis, offering novel insight into the potential application of TUG1 for childhood asthma treatment.
transcription factor target	34749575	hsa-mir-26a	Liver Injury	BACKGROUNDS: miR-26a-5p is a short noncoding RNA that is abnormally expressed in drug-induced liver injury (DILI), but its pathophysiologic role in the mechanism of disease in DILI is still vague. CONCLUSIONS: miR-26a-5p played a protective role against DILI via targeting Bid.
lncRNA target	34749521	hsa-mir-4521	Stomach Neoplasms	MiR-4521 inhibition or PIK3R3 over-expression weakened the anti-cancer functions of sulforaphane in gastric carcinoma cells.
circulation_biomarker_diagnosis_up	34749366	hsa-mir-381	Inflammation	3p is less expressed in the serum of AD patients and has potential diagnostic values for AD.
circulation_biomarker_diagnosis_up	34749366	hsa-mir-381	Alzheimer Disease	3p is less expressed in the serum of AD patients and has potential diagnostic values for AD.
circulation_biomarker_diagnosis_up	34749366	hsa-mir-381	Neurotoxicity Syndromes	3p is less expressed in the serum of AD patients and has potential diagnostic values for AD.
lncRNA target	34749249	hsa-mir-218	Myocardial Reperfusion Injury	5p choked oxidative stress and inflammation in myocardial I/R injury via targeting MEF2C/NF-kappaB axis, thus relieving the disease progression.
other	34748956	hsa-mir-146a	Diabetes Mellitus	In this study, we define the mechanism(s) by which CNP-miR146a improves diabetic wound healing by examining immunohistochemical and gene expression analysis of markers of inflammation, oxidative stress, fibrosis, and angiogenesis.
transcription factor target	34748611	hsa-mir-155	Arthritis, Rheumatoid	"Consistent with this, ES-62 ""rewiring"" of SFs away from the hyper-responsive phenotype is associated with suppression of ERK activation, STAT3 activation and miR-155 upregulation, signals widely associated with SF pathogenesis."
genetics_overexpression_promote	34748526	hsa-mir-345	Adenocarcinoma of Lung	Rescue assays revealed that overexpression of RhoA rescued the suppressive effects of miR
transcription factor target	34748368	hsa-mir-101a	Inflammation	Upregulated miR1 and miR-101a inhibited LPS-induced inflammatory cytokine production by targeting tumor necrosis factor receptor-associated factor 6 (TRAF6), thus avoiding excessive inflammation.
lncRNA target	34747666	hsa-mir-495	Esophageal Neoplasms	Conclusions: MiR-495 suppressed cisplatin resistance and angiogenesis in esophageal cancer cells by targeting ATP7A gene expression.
transcription factor target	34747545	hsa-mir-122	Alopecia	These findings suggested that upregulation of miR-122 induces apoptosis, potentially via the repression of IGF1R in hDPCs of AGA, providing a novel insight into the potential pathological mechanism of miR-122 in AGA DPCs.
other	34747544	hsa-mir-200c	familial multiple nevi flammei	Our findings suggest that the significant downregulation of miR-200c/429 in CMCs maintains the expression of N-Cadherin, which may be important for its functional integrity.
other	34747544	hsa-mir-429	familial multiple nevi flammei	We found significant downregulation of miR-200c and miR-429 in CMCs. Our findings suggest that the significant downregulation of miR-200c/429 in CMCs maintains the expression of N-Cadherin, which may be important for its functional integrity.
transcription factor target	34747314	hsa-mir-138	Breast Neoplasms	miR-138 targeted regulation of SEMA4C can promote the expression of N-cad, inhibit the expression of E-cad, vim and SEMA4C, reverse the EMT of BC cells, and inhibit the activity and invasion of BC cells.
other	34747300	hsa-mir-758	Carcinoma, Non-Small-Cell Lung	3p, thereby promoting NSCLC progression.
other	34747300	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	3p, thereby promoting NSCLC progression.
other	34747300	hsa-mir-585	Carcinoma, Non-Small-Cell Lung	3p, thereby promoting NSCLC progression.
transcription factor target	34747081	hsa-mir-181b	Pre-Eclampsia	At molecular level, the expression level of miR-181b-5p was both induced in vivo and in vitro with the development of PE symptoms, contributing to the inhibited expression of RBAK. The induced expression of miR-181b-5p under Pue treatment showed that the re-induction of miR-181b-5p counteracted the effects of Pue, indicating the key role of the miR in the protective effects of Pue against PE.
transcription factor target	34747081	hsa-mir-181b	Inflammation	At molecular level, the expression level of miR-181b-5p was both induced in vivo and in vitro with the development of PE symptoms, contributing to the inhibited expression of RBAK. The induced expression of miR-181b-5p under Pue treatment showed that the re-induction of miR-181b-5p counteracted the effects of Pue, indicating the key role of the miR in the protective effects of Pue against PE.
lncRNA target	34746996	hsa-mir-146b	Pituitary Neoplasms	CONCLUSIONS: MiRNA-146b-5p can inhibit EPHA7 expression, suppress the IRAK4/TRAF6/NF-kappaB signaling pathway, and weaken PA cell invasion, metastasis, proliferation, and TMZ-induced chemoresistance in vitro.
exosome	34746322	hsa-mir-126	Hepatoblastoma	CONCLUSIONS: Exosomal miR-126 derived from hepatoblastoma cells promoted the tumorigenesis of liver cancer through inducing the differentiation of BMSCs into cancer stem cells.
genetics_overexpression_suppress	34746238	hsa-mir-142	Leukemia, Myeloid, Acute	3P have a negative correlation with DUBR and overexpression of miRNA
other	34746237	hsa-mir-182	Autism Spectrum Disorder	5p/S100A2.
other	34746237	hsa-mir-221	Autism Spectrum Disorder	5p/S100A2.
other	34746237	hsa-mir-132	Autism Spectrum Disorder	5p/S100A2.
lncRNA target	34746123	hsa-mir-503	Bone Diseases	Thus, the present study demonstrated that the lncRNAs LOC100126784 and POM121L9P facilitate the osteogenic differentiation of BMSCs via the miR5p/SORBS1 axis, providing potential therapeutic targets for treating osteoporosis and bone defects.
lncRNA target	34746123	hsa-mir-503	Osteoporosis	Thus, the present study demonstrated that the lncRNAs LOC100126784 and POM121L9P facilitate the osteogenic differentiation of BMSCs via the miR5p/SORBS1 axis, providing potential therapeutic targets for treating osteoporosis and bone defects.
other	34746118	hsa-mir-190a	Stomach Neoplasms	The results of bioinformatics analysis showed that the expression of NR2F1-AS1/miR-190a/PHLDB2 in GC was positively associated with the pathological features, staging, poor prognosis, and EMT process. Thus, our results showed that NR2F1-AS1/miR-190a/PHLDB2 promoted the phosphorylation of AKT3 to induce EMT in GC cells.
target gene	34746018	hsa-mir-206	Uterine Cervical Neoplasms	LncRNA OTUD6B-AS1 Induces Cisplatin Resistance in Cervical Cancer Cells Through Up-Regulating Cyclin D2 via miR-206.
transcription factor target	34745992	hsa-mir-122	Carcinoma, Hepatocellular	Together, these findings suggest that AR could suppress HCC invasion and migration capacities via miR
target gene	34745940	hsa-mir-125b	Breast Neoplasms	LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network.
other	34745937	hsa-mir-223	Stomach Neoplasms	Long Noncoding RNA KLF3-AS1 Acts as an Endogenous RNA of miR-223 to Attenuate Gastric Cancer Progression and Chemoresistance.
target gene	34745557	hsa-mir-1	Colorectal Neoplasms	Propofol regulates miR-1-3p/IGF1 axis to inhibit the proliferation and accelerates apoptosis of colorectal cancer cells.
lncRNA target	34745428	hsa-mir-25	Myocardial Infarction	Collectively, M1-BMMs-EVs inhibited angiogenesis and myocardial regeneration following MI via the MALAT1/miR
lncRNA target	34745323	hsa-mir-19a	Urinary Bladder Neoplasms	CONCLUSION: miR-19a-3p facilitates cell progression in BLCA via binding THBS1, which may be an underlying therapeutic target for BLCA treatment.
lncRNA target	34745257	hsa-mir-96	Thyroid Cancer, Papillary	5p/PKN2 axis was closely related to the progression of PTC, which could be a potential target for treating PTC patients.
transcription factor target	34745206	hsa-mir-139	autosomal recessive congenital bilateral absence of vas deferens	In conclusion, these results suggest that miR5p plays an important role in osteogenic differentiation of VICs via the Wnt/beta-Catenin pathway, which may further provide a new therapeutic target for CAVD.
lncRNA target	34745118	hsa-mir-127	Lupus Nephritis	3p contributes to the overactivation of IFN-I signaling pathway in the kidneys of LN patients through promoting the expression of JAK1, suggesting hsa-miR
other	34744440	hsa-mir-197	Asthma	3p, miR-193a-5p, miR-1246, and miR-92b-3p).
other	34744440	hsa-mir-92b	Asthma	3p, miR-193a-5p, miR-1246, and miR-92b-3p).
other	34744440	hsa-mir-193a	Asthma	3p, miR-193a-5p, miR-1246, and miR-92b-3p).
other	34744440	hsa-mir-124	Asthma	3p, miR-193a-5p, miR-1246, and miR-92b-3p).
transcription factor target	34744440	hsa-mir-1246	Asthma	The most promising causal miRNA candidate, miR-1246, was examined in an in vitro system to explore its targets and roles in asthma pathophysiology. Strikingly, among all screened miRNAs, miR-1246, which could interact with POSTN may have multifunctional effects in the course of asthma and be a promising agent for asthma treatment and molecular subtyping.
transcription factor target	34744059	hsa-mir-214	Femur Head Necrosis	CONCLUSIONS: miR-214 participates in the inhibition of osteoblastic bone formation, and the inhibition of miR-214 to bone formation during transplantation therapy with Bio-Oss combined with BMSCs for ONFH.
lncRNA target	34743973	hsa-mir-182	Splenic Diseases	Therefore, CAPE could be a food-derived spleen protector to counteract Cd-induced spleen toxicity through alleviating apoptosis and inflammation via the miR5p/TLR4/NF-kappaB axis.
lncRNA target	34743948	hsa-mir-182	Depression	CONCLUSIONS: The results suggested that activation of NF-kappaB inhibited GPR39/CREB/BDNF pathway through increasing miR-182 in chronic stress-induced depressive-like behaviors.
transcription factor target	34743685	hsa-mir-16	Breast Neoplasms	5p and knock-down of ANLN remarkably inhibited cell proliferation and migration as well as cell invasion, arrested the cells in G2/M phase and induced apoptosis in BC cells.
other	34743291	hsa-mir-155	ankylosing spondylitis 1	Furthermore, miR-146a, miR-125a-5p, miR-125b-5p, miR-499a, and miR-155a could have potential diagnostic value in AS.
other	34743291	hsa-mir-125a	ankylosing spondylitis 1	Furthermore, miR-146a, miR-125a-5p, miR-125b-5p, miR-499a, and miR-155a could have potential diagnostic value in AS.
epigenetics	34743198	hsa-mir-124-2	Muscular Dystrophy, Duchenne	METHODS: This study evaluated the discriminative power of FAM19A4/miR124-2 methylation, HPV16/18 genotyping and HPV16/18/31/33/45 genotyping in HPV-positive women with BMD (n = 294) in two Dutch screening trials. CONCLUSION: The use of FAM19A4/miR124-2 methylation and/or HPV genotyping in HPV-positive women with BMD can lead to a substantial reduction in the number of direct colposcopy referrals.
transcription factor target	34743197	hsa-mir-9	Sepsis	This study also highlights the proinflammatory mechanism associated with miR5p-mediated inhibition of SIRT1, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
target gene	34742920	hsa-mir-183	Liver Neoplasms	ABAT targeted by miR-183-5p regulates cell functions in liver cancer.
genetics_overexpression_promote	34742738	hsa-mir-140	Asthma	Finally, rescue assays demonstrated that GSK3beta overexpression rescued the effects of miR-140 on asthma progression.
genetics_overexpression_promote	34742738	hsa-mir-140	Airway Inflammation	Finally, rescue assays demonstrated that GSK3beta overexpression rescued the effects of miR-140 on asthma progression.
circulation_biomarker_diagnosis_up	34742341	hsa-mir-146a	Atherosclerosis	CONCLUSION: Therefore, SCIRT is downregulated in atherosclerosis and it suppresses the proliferation of HAOSMCs by sponging miR-146a in cytoplasm.
circRNA target	34742305	hsa-mir-1224	Colorectal Neoplasms	5p inhibitor.
circulation_biomarker_diagnosis_up	34742256	hsa-mir-214	Norrie disease	RESULTS: Results from the experiments manifested up-regulated levels of NNT-AS1 and smad4 in the blood samples of DN patients as well as in HGMCs, whereas, downregulated levels of miR
other	34742151	hsa-mir-326	Pre-Eclampsia	Circ_0032962 could contribute to trophoblast cell growth ability and metastasis partly by regulating the miR-326/PBX3 axis, providing a novel insight into the pathogenesis and treatment of PE.
other	34742033	hsa-mir-140	Urinary Bladder Neoplasms	S100A7 was predicted to directly interact with LYZ, which potentially shows competitive binding with hsa-mir-140 to affect the expression of six lncRNAs in MIBC.
lncRNA target	34741930	hsa-mir-326	Pulmonary Fibrosis	Our study uncovered a key mechanism by which lnc-SNHG1 regulated pulmonary fibrosis through miR-326/SP1 axis, and lnc-SNHG1 is a potential target for the prevention and treatment of silicosis.
other	34741437	hsa-mir-214	Lung Neoplasms	3p to upregulate TGIF2 expression, thereby promoting the progression of lung cancer cells.
exosome	34741385	hsa-mir-21	Osteosarcoma	5p-abundant exosomes derived human bone marrow MSCs could activate PI3K/Akt/mTOR pathway by suppressing PIK3R1 expression in osteosarcoma cells.
genetics_knock down_suppress	34741382	hsa-mir-32	Mouth Neoplasms	5p, and knockdown of KLF2 abolished the inhibitory effect of miR
lncRNA target	34741343	hsa-mir-146b	Neurodevelopmental Injuries	INTERPRETATIONS: These findings support that miRNA-146b-5p is a major regulator of microglia phenotype and could be targeted to reduce the incidence and the severity of perinatal brain injuries and their long-term consequences.
other	34741317	hsa-mir-4319	Colorectal Neoplasms	Our results reveal the mechanism of the lnc-CPLC/miR-4319/ZBTB34 signal axis in CRC and provide evidence for elucidating the complex molecular mechanisms in tumors.
genetics_GWAS	34741119	hsa-mir-139	Leukemia, Myeloid, Acute	We revealed that two enhancer regions control MIR139 expression and found that the polycomb repressive complex 2 (PRC2) downstream of MLL-AF9 epigenetically silenced MIR139 in AML.
other	34740994	hsa-mir-26a	Triple Negative Breast Neoplasms	In general, our study found (1) miR-26a-5p was a protective factor of breast cancer, while OTUD6B-AS1 and MTDH were risk factors; (2) OTUD6B-AS1 was the up-stream regulator of miR-26a-5p verified by luciferase; (3) up-regulation of miR-26a-5p and down-regulation of MTDH promoted cellular cytotoxicity of paclitaxel (PTX) in vitro and in vivo.
other	34740784	hsa-mir-141	Legg-Calve-Perthes Disease	3p and miR-30a promoted osteoclastogenesis in vitro.
other	34740784	hsa-mir-4644	Legg-Calve-Perthes Disease	3p and miR-30a promoted osteoclastogenesis in vitro.
other	34740784	hsa-mir-3133	Legg-Calve-Perthes Disease	3p and miR-30a promoted osteoclastogenesis in vitro.
other	34740784	hsa-mir-4693	Legg-Calve-Perthes Disease	3p and miR-30a promoted osteoclastogenesis in vitro.
genetics_overexpression_promote	34740363	hsa-mir-182	Polycystic Ovary Syndrome	Moreover, miR-182 overexpression suppressed cell proliferation and cell cycle process and promoted cell apoptosis in PCOS GCs and KGN cells by targeting SGK3.
genetics_knock down_promote	34740278	hsa-mir-1229	Carcinoma, Hepatocellular	3p facilitated cell viability and metastasis of HCC cells while knockdown of miR
other	34740040	hsa-mir-9	Uterine Cervical Neoplasms	5p in cervical cancer cells.
lncRNA target	34740018	hsa-mir-145	Tuberculosis, Pulmonary	Hence, we concluded that immunoheterogeneity exists among TB patients and NFATC1-(miR145)-STAT1 regulatory pathway might be associated with tuberculosis infection, which may be valuable targets for prevention and treatment of tuberculosis.
lncRNA target	34739601	hsa-mir-171f	Dwarfism	High-throughput sequencing and yeast one and two-hybrid library screening reveal that DKGA2ox1 and miR171f_3 are involved in the regulation of scion dwarfing with 'Nan-tong-xiao-fang-shi' as interstocks. These results indicate that DKGA2ox1 and miR171f_3 may co-promote the scion dwarfing by plant hormone signal transduction pathways.
other	34739167	hsa-mir-1231	Squamous Cell Carcinoma of Head and Neck	Besides, circ_0002141 could sponge miR-1231 and upregulate EGFR expression in OSCC cells. CONCLUSION: Circ_0002141/miR-1231/EGFR axis is involved in the progression of OSCC.
genetics_overexpression_promote	34739163	hsa-mir-590	Periodontitis	3p overexpression improved osteogenic differentiation of hPDLSCs in periodontitis.
transcription factor target	34738916	hsa-mir-652	Growth Hormone-Secreting Pituitary Adenoma	Downregulated miR-216a-5p and miR3p expression may contribute to tumour progression by targeting JAK2 and PRRX1 on GH-producing pituitary tumours.
transcription factor target	34738916	hsa-mir-216a	Growth Hormone-Secreting Pituitary Adenoma	Downregulated miR-216a-5p and miR3p expression may contribute to tumour progression by targeting JAK2 and PRRX1 on GH-producing pituitary tumours.
other	34738893	hsa-mir-146a	Coronary Disease	PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation.
other	34738893	hsa-mir-23a	Coronary Disease	PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation.
other	34738893	hsa-mir-223	Coronary Disease	PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation.
genetics_overexpression_promote	34738872	hsa-mir-877	Osteosarcoma	3p overexpression was found to inhibit the proliferation of OS cell lines.
lncRNA target	34738869	hsa-mir-513b	Breast Neoplasms	However, to date, the functional role and underlying regulatory mechanism of LINC00675 and miR-513b-5p in BC remains largely unknown. Collectively, the central findings of our study suggest that LINC00675 represses BC progression through the inhibition of miR-513b-5p in a m(6)A-dependent manner.
other	34738867	hsa-mir-223	Acute Uterine Injury	Collectively, we concluded that BMSCs-exo upregulated miR3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI.
genetics_knock down_promote	34738865	hsa-mir-124a	Adenocarcinoma of Lung	Moreover, LINC00960 sponged miR-124a to inhibit the SphK1/S1P pathway in LADC cells. In addition, miR-124a downregulation or SphK1 upregulation reversed the inhibitory effects of LINC00960 knockdown on cellular functions of LADC cells, suggesting that LINC00960 may be a potential therapeutic biomarker for LADC via the miR-124a/SphK1 axis.
lncRNA target	34738862	hsa-mir-1207	Nasopharyngeal Carcinoma	5p expression and affecting TEAD1 expression, thus inhibiting the activation of Hippo/YAP signaling pathway.
genetics_knock down_promote	34738852	hsa-mir-423	Thyroid Cancer, Papillary	Circ_0039411 knockdown-mediated effects in papillary thyroid carcinoma cells were largely overturned by the silence of miR
circulation_biomarker_diagnosis_ns	34738631	hsa-mir-145	Fibrosis	The expression levels of MEG3 and microRNA (miR)145 in the serum of healthy volunteers and patients with liver fibrosis and in LX2 cells were detected using reverse transcriptionquantitative PCR.
other	34738503	hsa-mir-20a	alpha-Thalassemia	Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.
other	34738503	hsa-mir-20a	Mental Retardation, X-Linked	Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.
other	34738503	hsa-mir-20a	Squamous Cell Carcinoma of Head and Neck	Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.
other	34738502	hsa-mir-149	Breast Neoplasms	5p/SLC1A5 pathway, providing a novel mechanism responsible for BC development.
genetics_knock down_promote	34738458	hsa-mir-361	Pancreatitis	Gain- and loss-of-function assays of miR
other	34738402	hsa-mir-199	Cardiomegaly	The mRNA expression of myocardial hypertrophy indicators(ANP and BNP), autophagy-related genes(Atg5, P62 and beclin1), and miR199 a-5 p was detected by qRT-PCR.
circulation_biomarker_prognosis_ns	34738345	hsa-mir-150	Sepsis	RESULTS: Multivariate analysis demonstrated that miR-150 (odds ratio (OR): 0.549, 95% confidence interval (95% CI) [0.372, 0.826], p < 0.001), the SOFA score (OR: 1.216, 95% CI [1.039, 1.807], p = 0.008), age, procalcitonin (PCT), and septic shock were independently associated with 28-day mortality of sepsis patients following the adjustment for chronic renal failure, hypertension, diabetes mellitus, activated partial thromboplastin time (APTT), serum creatinine (SCr), blood urea nitrogen (BUN), and total bilirubin (TBil).
other	34738200	hsa-mir-153	Laryngeal Neoplasms	CONCLUSIONS: Our results indicate that hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer by sponging miR-153 and inducing Twist1 nuclear translocation.
genetics_overexpression_promote	34737955	hsa-mir-449a	Colorectal Neoplasms	Either activation of autophagy by the inducer or overexpression of exogenous miR-449a decreases the expression of target gene LEF-1 and cyclin D1, which lead to decreased proliferation, colony formation, migration, and invasion of CRC cells.
target gene	34737805	hsa-mir-4486	Colonic Neoplasms	miR-4486 reverses cisplatin-resistance of colon cancer cells via targeting ATG7 to inhibiting autophagy.
circulation_biomarker_diagnosis_up	34737798	hsa-mir-185	Diabetes Mellitus	The expression of NOS2 was upregulated and the expression of miR-185 was downregulated in the blood from patients with diabetes.
lncRNA target	34737762	hsa-mir-222	Thyroid Neoplasms	3p and its critical target genes could be promising biomarkers for the prognosis of THCA and may emerge as key regulators of immune infiltration in THCA.
genetics_overexpression_promote	34737643	hsa-mir-4500	Precursor Cell Lymphoblastic Leukemia-Lymphoma	In this study, we investigated how LINC00265 and miR-4500 regulate the malignant characteristics of ALL. Furthermore, miR-4500 inhibitors or overexpressed LINC00265 up-regulated STAT3 expression, and miR-4500 mimics or STAT3 shRNAs eliminated the LINC00265-induced malignancy of the ALL cells.
transcription factor target	34737423	hsa-mir-28	Osteoarthritis	In conclusion, our data reveal that AC008 plays a critical role in OA pathogenesis via the miR
other	34737026	hsa-mir-122	Diabetes Mellitus, Type 2	In the mediation analysis, miR5p mediated 48.0% of the association between Ti and diabetes risk.
circulation_biomarker_diagnosis_ns	34736693	hsa-mir-210	Triple Negative Breast Neoplasms	In this work, a novel electrochemiluminescence (ECL) sensor has been developed to detect miRNA-210 in the serum of triple negative breast cancer (TNBC) patients.
lncRNA target	34736391	hsa-mir-200a	Kidney Diseases	CONCLUSION: LncRNA-ATB promoted the COM-induced cell injury, cell apoptosis, proliferation inhibition, and EMT to participate in the process of CaOx crystal-induced renal injury by sponging miR-200s.
lncRNA target	34736391	hsa-mir-200	Kidney Diseases	CONCLUSION: LncRNA-ATB promoted the COM-induced cell injury, cell apoptosis, proliferation inhibition, and EMT to participate in the process of CaOx crystal-induced renal injury by sponging miR-200s.
genetics_overexpression_promote	34736163	hsa-mir-552	Carcinoma, Non-Small-Cell Lung	3p inhibitor, Fibulin 5 (FBLN5) overexpression plasmid, and small interfering FBLN5 (siFBLN5) and treated with extracellular regulated protein kinases (ERK) pathway inhibitor PD98059.
exosome	34735868	hsa-mir-875	Stomach Neoplasms	CONCLUSION: GCCs-exosomal lncRNA HCG18 elevated KLF4 expression by decreasing miR
other	34735495	hsa-mir-153	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
other	34735495	hsa-mir-572	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
other	34735495	hsa-mir-29c	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
other	34735495	hsa-mir-208a	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
other	34735495	hsa-mir-29b	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
other	34735495	hsa-mir-29a	Diabetic Nephropathies	Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy.
lncRNA target	34735003	hsa-mir-494	Pulmonary Fibrosis	Our study indicated that PM2.5 exposure triggered EMT progression to promote the pulmonary fibrosis via miR3p/YTHDF2 recognized and METTL3 mediated m6A modification.
genetics_knock down_suppress	34734406	hsa-mir-519d	Lung Neoplasms	LINC00839 competitively sponged miR-519d-3p, increasing JMJD6 expression, LC cell viability, invasion, migratory abilities and decreasing apoptosis rates in A549 and H460 lung cancer cells, which were hindered after JMJD6 knockdown. CONCLUSIONS: LINC00839/miR-519d-3p/JMJD6 axis mediated cell viability, apoptosis, and migration and invasiveness of H460 lung cancer cells.
other	34734021	hsa-mir-134	Tourette Syndrome	CONCLUSIONS: The rat models of TS and comorbid fear have similar changes in behaviors and miRNA-134 level to those in clinical settings and therefore can be used as a reliable animal model to study the mechanism of action of TS and comorbid fear.
transcription factor target	34734010	hsa-mir-205	Pulmonary Arterial Hypertension	3p may be potential therapeutic targets in patients with SSc-PAH.
transcription factor target	34734010	hsa-mir-205	Scleroderma, Systemic	3p may be potential therapeutic targets in patients with SSc-PAH.
transcription factor target	34734010	hsa-mir-539	Pulmonary Arterial Hypertension	3p may be potential therapeutic targets in patients with SSc-PAH.
transcription factor target	34734010	hsa-mir-539	Scleroderma, Systemic	3p may be potential therapeutic targets in patients with SSc-PAH.
genetics_overexpression_promote	34733975	hsa-mir-29c	Squamous Cell Carcinoma of Head and Neck	In addition, miR-29c overexpression inhibited the proliferation and metastasis of OSCC cells, and the subsequent rescue experiment showed that SERPINH1 overexpression can reverse the inhibitory effect of miR-29c in OSCC cell proliferation, migration, apoptosis, and cell cycle arrest.
lncRNA target	34733962	hsa-mir-151	Corneal Allograft Rejection	5p alleviated CGR by activating the PI3K/AKT signaling pathway and balancing Th17/Treg via targeting of IL-2Ra, which contributes to improving the results of CT.
transcription factor target	34733957	hsa-mir-155	Inflammation	5p and performing negative regulation analysis, six target genes were obtained in GCs.
transcription factor target	34733957	hsa-mir-155	Polycystic Ovary Syndrome	5p and performing negative regulation analysis, six target genes were obtained in GCs.
transcription factor target	34733957	hsa-mir-106	Polycystic Ovary Syndrome	5p and performing negative regulation analysis, six target genes were obtained in GCs.
transcription factor target	34733957	hsa-mir-106	Inflammation	5p and performing negative regulation analysis, six target genes were obtained in GCs.
lncRNA target	34733939	hsa-mir-223	Hepatitis C	CONCLUSIONS: Our findings indicate KCNQ1OT1 promotes HCV-infected beta-cell pyroptosis through the miRNA3p/NLRP3 axis, effecting the production of insulin and accelerating the occurrence and development of T2DM.Regulating KCNQ1OT1 and its target genes will help to better understand the pathogenesis of T2DM induced by HCV infection and provide new theoretical foundations and therapeutic targets.
exosome	34733928	hsa-mir-16	Fever	NPCs were pretreated with 10 ng/mL TNF-alpha, transfected with miR-16 inhibitors, and the exosomes were isolated. CONCLUSIONS: The inflammatory factor TNF-alpha stimulated exosome release from NPCs, which induced the apoptosis of normal NPCs through the actions of exosomal miR-16.
genetics_knock down_promote	34733926	hsa-mir-552	Gallbladder Neoplasms	3p was employed to knockdown this miRNA in GBC cell lines.
other	34733921	hsa-mir-214	Colorectal Neoplasms	5p-JAG1 regulatory axis, in exploring the cancer-promoting mechanism of lncRNA FTX in CRC.
other	34733854	hsa-mir-7	Glioblastoma	Burst keywords in recent years included glioblastoma, miR-7, skeletal muscle, and non-coding RNA.
genetics_overexpression_promote	34733825	hsa-mir-181a-2	Stomach Neoplasms	3p and MYLK were simultaneously overexpressed.
genetics_overexpression_promote	34733662	hsa-mir-124	Carcinoma, Renal Cell	Functionally, the overexpression of miR-124 reduced the sensitivity of renal cancer cells to cisplatin and CAPN4 was found to be a direct target of miR-124, which can negatively regulated CAPN4 expression.
lncRNA target	34733371	hsa-mir-135a	Carcinoma, Non-Small-Cell Lung	Altogether, the present study suggests that FOXD3-AS1 sponges miR-135a-5p to promote cell proliferation and concomitantly inhibit apoptosis by regulating CDK6 expression in NSCLC cells.
other	34733360	hsa-mir-152	ovary adenocarcinoma	In conclusion, MYCNOS may act by sponging miR-152 to upregulate MKK7 expression in OA, thereby promoting cell proliferation.
lncRNA target	34733326	hsa-mir-185	Colorectal Neoplasms	UCA1 promotes CRC metastasis through regulating the miR-185/NOTCH3 axis.
target gene	34733314	hsa-mir-320d	Colorectal Neoplasms	MiR-320d Inhibits Progression of EGFR-Positive Colorectal Cancer by Targeting TUSC3.
genetics_knock down_promote	34732848	hsa-mir-211	Cardiomegaly	Furthermore, overexpression of TINCR suppressed TAC-induced cardiac hypertrophy in vivo by targeting miR
genetics_GWAS	34732693	hsa-mir-497	Choriocarcinoma	Silencing miR5p and SALL4 promotes choriocarcinoma progression and forms a feedback loop with DNMT-mediated epigenetic regulation, playing a crucial role in stemness maintenance in choriocarcinoma.
circulation_biomarker_diagnosis_ns	34732690	hsa-mir-4449	Diabetic Nephropathies	CONCLUSIONS: Our study uncovered a novel mechanism for the progression of DKD that is mediated through miR-4449 in serum exosomes, which highlights an important role for exosomes in the pathogenesis of DKD.
target gene	34732362	hsa-mir-218	Liver Neoplasms	Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression.
circRNA target	34732216	hsa-mir-198	Breast Neoplasms	CONCLUSIONS: Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR
circRNA target	34732216	hsa-mir-136	Breast Neoplasms	CONCLUSIONS: Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR
other	34732212	hsa-mir-223	Acute Lung Injury	Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury.
other	34732131	hsa-mir-17	Cardiotoxicity	5p which may be involved in the regulation of genes associated with AIC.
other	34732131	hsa-mir-146a	Cardiotoxicity	5p which may be involved in the regulation of genes associated with AIC.
other	34732131	hsa-mir-15b	Cardiotoxicity	5p which may be involved in the regulation of genes associated with AIC.
other	34732131	hsa-mir-424	Cardiotoxicity	5p which may be involved in the regulation of genes associated with AIC.
circulation_biomarker_diagnosis_down	34731387	hsa-mir-126	Norrie disease	5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells.
circulation_biomarker_diagnosis_down	34731387	hsa-mir-204	Norrie disease	5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells.
circulation_biomarker_diagnosis_up	34731387	hsa-mir-204	Hyperglycemia	5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells.
circulation_biomarker_diagnosis_up	34731387	hsa-mir-126	Hyperglycemia	5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells.
genetics_knock down_promote	34731384	hsa-mir-370	Acute Kidney Injury	Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI.
genetics_knock down_promote	34731384	hsa-mir-370	Sepsis	Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI.
circRNA target	34730838	hsa-mir-488	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ_0000376 downregulation blocked the development of NSCLC by targeting the miR3p/BRD4 network and suppressing the PI3K/PKB pathway, which broadens knowledge into the understanding of the role of circ_0000376 in NSCLC.
circRNA target	34730679	hsa-mir-193a	Carcinoma, Hepatocellular	Circ_0001806 could up-regulate MMP16 expression through repressing miR-193a-5p, thereby facilitating the malignant biological behaviors of HCC.
circulation_biomarker_prognosis_up	34730612	hsa-mir-128	Ischemic Stroke	CONCLUSION: Assessment of serum miR
circulation_biomarker_prognosis_up	34730612	hsa-mir-9	Ischemic Stroke	CONCLUSION: Assessment of serum miR
other	34730446	hsa-mir-22	Cleft Palate	CONCLUSIONS: Results from the current study suggest a key role for miR-22 in the removal of the MES during palatogenesis and that miR-22 may represent a potential contributor to the etiology of cleft palate.
other	34730432	hsa-mir-211	Cognition Disorders	5p displayed reduced cortical apoptosis levels and near-term cognitive impairment.
lncRNA target	34730253	hsa-mir-1271	Diabetes Mellitus	This study evaluated anti-diabetic activity of hydroxybenzoic acid derivatives and determined the involvement of miR-1271. This study assessed the anti-diabetic activity of hydroxybenzoic acid derivatives through down-regulation of microRNA-1271 and its association with the IRS1/PI3K/AKT/FOXO1 pathways.
genetics_overexpression_promote	34730202	hsa-mir-499b	Uterine Cervical Neoplasms	MiR-499b-5p overexpression prevented the tumorigenesis and development of cervical cancer in xenograft tumor models.
lncRNA target	34730201	hsa-mir-26a	Carcinoma, Hepatocellular	CONCLUSIONS: LINC00205, a novel YY1-modulated lncRNA, can facilitate the proliferation of HCC cells through YY1/miR-26a-5p/CDK6 pathway, and may serve as a promising diagnostic biomarker and therapeutic target for HCC.
genetics_knock down_suppress	34730199	hsa-mir-451	Thyroid Neoplasms	CONCLUSIONS: Our results indicated that the cell migration and invasion were inhibited by knockdown of lncRNA NORAD or overexpression of miR-451, suggesting that the axis of lncRNA NORAD -miR
genetics_knock down_promote	34730059	hsa-mir-495	Acute Kidney Injury	3p/TRAF6 axis via NF-kappaB/p65 signalling pathway, providing a novel mechanism in clinical treatment of AKI patients.HighlightsCirc_0114427 is upregulated in serum specimens from septic AKI patients and LPS-induced HK-2 cells.LPS treatment suppresses cell viability and promotes apoptosis and inflammation in HK-2 cells.Circ_0114427 knockdown ameliorates the effects of LPS on cell viability, apoptosis and inflammation in HK-2 cells.Circ_0114427 regulates LPS-induced HK-2 cell injury by regulating miR
transcription factor target	34730058	hsa-mir-144	Arthritis, Rheumatoid	3p induced by SP1 could promote IL-1beta-induced chondrocyte pyroptosis via inhibiting PTEN expression and suppressing the activation of PINK1/Parkin signalling, which provided a new strategy against RA.
genetics_knock down_promote	34730058	hsa-mir-144	Necrobiotic Disorders	3p knockdown inhibited IL-1beta-induced pyroptosis in N1511 cells, and the expressions of NOD-like receptor family pyrin domain containing 3 (NLRP3), Cleaved caspase-1, Gasdermin D (GSDMD), and Cleaved caspase-3 in IL-1beta-stimulated N1511 cells were increased.
lncRNA target	34729750	hsa-mir-363	Hemangioma	Down-regulating HNF1A-AS1 may inhibit proliferation, migration and invasion of IL
genetics_knock down_promote	34729394	hsa-mir-20b	Esophageal Squamous Cell Carcinoma	Moreover, overexpression of miR-320b promotes the proliferation, migration, invasion, and epithelial-mesenchymal transition progression of ESCC cells.
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-801	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-223	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-122	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-27a	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-26a	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-192	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
circulation_biomarker_diagnosis_ns	34729120	hsa-mir-21	Carcinoma, Hepatocellular	Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT).
lncRNA target	34729115	hsa-mir-375	Esophageal Squamous Cell Carcinoma	These findings suggest that miR-375 acts as a tumor suppressor by blocking the ERBB2/VEGFA pathway with the potential to modulate the occurrence and/ or progression of EC.
target gene	34729113	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	MiR-182-5p promotes the Metastasis and Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer by Targeting EPAS1.expression.
lncRNA target	34729101	hsa-mir-491	Glioma	Conclusion: LBX2-AS1 is upregulated by SP1 in glioma, which promotes the progression of glioma by targeting the miR5p/LIF axis.
lncRNA target	34728806	hsa-mir-662	Triple Negative Breast Neoplasms	Since miR-3662 expression occurs a tumor-specific manner, it is a promising biomarker and therapeutic target for patients who have TNBCs with dysregulation of miR-3662, especially African Americans.
other	34728784	hsa-mir-17	Stomach Neoplasms	5p and HOXA11-AS activation in GC cells.
transcription factor target	34728702	hsa-mir-146a	Acne Vulgaris	These findings correlated with our in situ hybridization results, that compared with control, miR-146a showed an increased, while GNG7 a decreased expression in sebaceous glands of acne samples. Our findings suggest, that miR-146a could be a potential player in acne pathogenesis by regulating inflammation, inducing proliferation and, through the indirect down-regulation of GNG7, promoting the lipid production of sebocytes.
lncRNA target	34728310	hsa-mir-130a	Glioma	KB-1460A1.5 was found to function as a competing endogenous RNA (ceRNA) to regulate the expression of TSC1, a key regulatory component of the mTOR pathway, by sponging miR-130a-3p in glioma cells. In conclusion, this study revealed that lncRNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop.
genetics_overexpression_promote	34728027	hsa-mir-145	Carcinoma, Ovarian Epithelial	5p(t=4.583,P=0.010).The cells with ARK5 overexpression showed increased proliferation rate(t=27.290,P<0.001)and decreased apoptosis rate(t=-8.241,P=0.001).The overexpression of miR
lncRNA target	34727954	hsa-mir-657	Stomach Neoplasms	CONCLUSION: KLF15-mediated TFAP2A-AS1 hampers cell proliferation and migration in GC via miR-3657/NISCH axis.
genetics_knock down_promote	34727925	hsa-mir-1229	Glioma	Additionally, VASP was demonstrated to be the target gene of miR-1179 and miR-1229, and VASP overexpression abolished the effect of circRFX3 knockdown on glioma cell progression.
genetics_knock down_promote	34727925	hsa-mir-1179	Glioma	Additionally, VASP was demonstrated to be the target gene of miR-1179 and miR-1229, and VASP overexpression abolished the effect of circRFX3 knockdown on glioma cell progression.
other	34727826	hsa-mir-187	Eclampsia	miR5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT)..
other	34727826	hsa-mir-146	Eclampsia	miR5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT)..
lncRNA target	34727409	hsa-mir-15a	Colorectal Neoplasms	Taken together, these data demonstrate that miR-15a-3p regulates ferroptosis through targeting GPX4 in CRC cells, illustrating the novel role of microRNA in ferroptosis.
other	34727290	hsa-mir-362	Breast Neoplasms	3p, were evaluated for functional activity in breast cancer cell lines and they showed increased proliferative signals and tumorigenic properties.
other	34727290	hsa-mir-454	Breast Neoplasms	3p, were evaluated for functional activity in breast cancer cell lines and they showed increased proliferative signals and tumorigenic properties.
other	34726256	hsa-mir-486	Bicuspid Aortic Valve Disease	The data suggested that miR486 may be considered as a noninvasive biomarker of aortic wall degeneration.
lncRNA target	34726120	hsa-mir-485	Glioblastoma	Our study revealed that CDDP retarded glioblastoma cell development via the miR
circRNA target	34725884	hsa-mir-6796	Ischemic Stroke	CONCLUSIONS: circSKA3 functioned as a ceRNA for hsa-miR5p to aggravate the progression of ischemic stroke via targeting MMP9.
circulation_biomarker_diagnosis_ns	34725544	hsa-mir-139	Duane Retraction Syndrome	The present results demonstrated that miR5p expression was notably reduced in the serum samples of patients with DR, as well as in ARPE-19 cells treated with HG in a time-dependent manner.
genetics_knock down_promote	34725544	hsa-mir-139	Inflammation	Mechanistically, knockdown of LMO4 reversed the biological role of miR
target gene	34725345	hsa-mir-576	Urinary Bladder Neoplasms	FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner.
circRNA target	34724864	hsa-mir-106b	Carcinoma, Non-Small-Cell Lung	The circSLC8A1/miR-106b-5p/FOXJ3 axis may thus represent a promising therapeutic target for the management of NSCLC.
exosome	34724826	hsa-let-7b	Hepatitis C	We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation.
exosome	34724826	hsa-mir-122	Hepatitis C	We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation.
exosome	34724826	hsa-mir-206	Hepatitis C	We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation.
lncRNA target	34724669	hsa-mir-21	Nephritis, Interstitial	This study aims to investigate whether PFD can attenuate TIF through inhibiting miR-21 in UUO rats.
genetics_knock down_promote	34724268	hsa-mir-576	Pneumonia, Mycoplasma	CONCLUSION: Circ_0037078 knockdown promotes trophoblast cell proliferation, migration, invasion, and angiogenesis in vitro by miR5p/IL1RAP axis, providing a novel insight into the etiology of PE.
circulation_biomarker_diagnosis_up	34723781	hsa-mir-889	Lung Neoplasms	3p and HIPK1-related plasmids in human LC cell line A549, several studies were employed for detection of cell growth.
lncRNA target	34723778	hsa-mir-495	Otitis Media with Effusion	Functional assays revealed that NEAT1 promoted the OME by targeting miR-495. Our study revealed that lncRNA NEAT1 served as a ceRNA to activate p38 MAPK signaling by targeting miR-495 in OME, which may offer a new target for OME treatment.
circulation_biomarker_prognosis_up	34723759	hsa-mir-1180	Colorectal Neoplasms	3p is downregulated in CRC tissues, blood and cells than normal ones.
transcription factor target	34723712	hsa-mir-9	Adenocarcinoma of Lung	5p promotes LUAD cell progression by modulating ID4 and may become a potential target for LUAD.
epigenetics	34723710	hsa-mir-204	Astrocytoma	5p expression is downregulated by DNA methylation.
circulation_biomarker_diagnosis_up	34722835	hsa-mir-127	Pelizaeus-Merzbacher Disease	5p, PDX1 and SPHK1 in the blood mononuclear cells (BMCs) of PMOP patients.
other	34722832	hsa-mir-181b	Graft vs Host Disease	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
other	34722832	hsa-mir-181b	COVID-19	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
other	34722832	hsa-mir-181a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
other	34722832	hsa-mir-181a	Graft vs Host Disease	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
other	34722832	hsa-mir-181b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
other	34722832	hsa-mir-181a	COVID-19	The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV.
circRNA target	34722778	hsa-mir-874	Carcinoma, Hepatocellular	Using luciferase binding assays, we proved that circ_0001588 functions as a molecular ceRNA of miR-874 and that CDK4 acts as a downstream target of miR-874 in HCC. In summary, our results indicate that circ_0001588 acts as a ceRNA and promotes HCC progression by targeting the miR-874/CDK4 signaling pathway.
other	34722769	hsa-mir-663b	Acute Lung Injury	CONCLUSION: Our research indicated that the hsa-miR-663b-related ceRNA network may contribute to the key regulatory mechanism in LPS-induced changes of autophagy and ALI.
lncRNA target	34722766	hsa-mir-27a	Familial Primary Pulmonary Hypertension	We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH.
lncRNA target	34722766	hsa-mir-27b	Familial Primary Pulmonary Hypertension	We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH.
lncRNA target	34722766	hsa-mir-26b	Familial Primary Pulmonary Hypertension	We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH.
other	34722763	hsa-mir-484	Epilepsy, Temporal Lobe	The differences in expression levels of the miR-484 and the three hub genes (CTD-3193O13.9, EFNA5, and PRKCB) observed experimentally in TLE patients compared to those of healthy controls were consistent with the WGCNA prediction. In addition, our results indicate that miR-484 may be a promising novel biomarker for TLE.
genetics_overexpression_promote	34722753	hsa-mir-582	Carcinoma, Non-Small-Cell Lung	CONCLUSION: circ_0002346 overexpression suppressed the malignant properties of NSCLC cells by binding to miR
exosome	34722652	hsa-mir-21	Fibrosis, Atrial	Conclusions: The blockade of exosome release with GW4869 suppressed AF by alleviating atrial fibrosis in a canine model, which was probably related to profibrotic miR5p enriched in exosomes and its downstream TIMP3/TGF-beta1 pathway.
exosome	34722652	hsa-mir-21	Atrial Fibrillation	Conclusions: The blockade of exosome release with GW4869 suppressed AF by alleviating atrial fibrosis in a canine model, which was probably related to profibrotic miR5p enriched in exosomes and its downstream TIMP3/TGF-beta1 pathway.
other	34722629	hsa-mir-520e	Glioma	Further bioinformatic analysis revealed that the SNHG16/hsa-miR-520e/SYDE1 axis might be involved in glioma development.
genetics_knock down_suppress	34722314	hsa-mir-27a	Carcinoma, Non-Small-Cell Lung	METHODS: Database, qRT-PCR, Western-blot (WB), and immunohistochemistry were utilized to determine SLC7A11 expression and function, as well as gene iron related to necrosis in clinical tissue specimens and cells; a ferroptosis inducer, inhibitors, and SLC7A11 lentivirus were used to confirm SLC7A11's biological activity in cell viability, oxidative stress, lipid peroxidation, and iron ion enrichment in non-small cell lung cancer (NSCLC) in different cells; lentivirus was used to infect lung adenocarcinoma cell lines to acquire miR-27a-3p overexpression and knockdown cell lines, and to detect SLC7A11 level through qRT-PCR and WB.
transcription factor target	34722307	hsa-mir-629	Prostatic Neoplasms	5p plays an oncogenic role in PCa by targeting AKAP13, which provides a new idea for clinical diagnosis and treatment of complex refractory PCa.
lncRNA target	34722282	hsa-mir-512	Stomach Neoplasms	5p, which targeted on TRIM28 and promoted cancer malignant behaviors of EBVaGC cells.
lncRNA target	34722233	hsa-mir-222	Carcinoma, Transitional Cell	3p/miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21, which, in turn, inhibited the progression of urothelial carcinoma and increased the sensitivity of cancer cells to cisplatin chemotherapy.
lncRNA target	34722233	hsa-mir-146a	Carcinoma, Transitional Cell	3p/miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21, which, in turn, inhibited the progression of urothelial carcinoma and increased the sensitivity of cancer cells to cisplatin chemotherapy.
circulation_biomarker_diagnosis_up	34721735	hsa-mir-135	Depression	Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR
circulation_biomarker_diagnosis_up	34721735	hsa-mir-34a	Depression	Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR
circulation_biomarker_diagnosis_up	34721735	hsa-mir-451	Depression	Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR
circulation_biomarker_diagnosis_up	34721735	hsa-mir-124	Depression	Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR
other	34721678	hsa-mir-98	Lupus Nephritis	MicroRNA (miR)5p has been reported to be involved in the development of lupus nephritis (LN); however, its specific role in LN remains unclear.
lncRNA target	34721678	hsa-mir-98	Lesch-Nyhan Syndrome	5p and BACH1 may represent potential therapeutic targets for LN.
genetics_overexpression_promote	34721589	hsa-mir-20a	Lupus Nephritis	The aim of our study was to investigate the efficacy of miR-20a overexpressing adipose-derived stem cell (ADSC) transplantation in murine lupus nephritis (LN) and explore potential molecular mechanisms. CONCLUSIONS: miR-20a-ADSC transplantation prevents the development of lupus nephritis and significantly ameliorates already-established disease, and its mechanism is related to autophagy by targeting the miR-20a-regulated mTOR pathway.
lncRNA target	34721576	hsa-mir-934	Carcinoma, Hepatocellular	In this study, our purpose is to explore the biological function of B3GALT5-AS1 in HCC and its coupling mechanism with miR-934 and ubiquitin-fold modifier 1 (UFM1). Our results demonstrated that B3GALT5-AS1 was an excellent HCC suppressant by regulating miR-934 and UFM1 to achieve negative regulation of HCC cell proliferation, invasion, and metastasis, indicating that B3GALT5-AS1 is a promising potential therapeutic target for HCC treatment.
lncRNA target	34721542	hsa-mir-147b	Osteoarthritis	More importantly, highly specific co-expression RNA (ceRNA) networks regulated by lncRNA LOC107986251-miR5p-SESN3 and hsa_circ_0018069-miR-147b-3p-TJP2 were screened out during IL-induced meniscus degeneration, unveiling potential therapeutic targets for meniscus degeneration during the OA process.
lncRNA target	34721542	hsa-mir-212	Osteoarthritis	More importantly, highly specific co-expression RNA (ceRNA) networks regulated by lncRNA LOC107986251-miR5p-SESN3 and hsa_circ_0018069-miR-147b-3p-TJP2 were screened out during IL-induced meniscus degeneration, unveiling potential therapeutic targets for meniscus degeneration during the OA process.
circRNA target	34721518	hsa-mir-452	Glioma	Taken together, our findings show that circTLK1 mediated by PBX2 activates JAK/STAT signaling to promote glioma progression through the miR5p/SSR1 pathway.
transcription factor target	34721432	hsa-mir-4512	Lupus Erythematosus, Systemic	TLR4-CXCL2 axis as a potential novel therapeutic target in SLE.
genetics_overexpression_suppress	34721048	hsa-mir-320d	Chordoma	NONHSAT114552 was overexpressed while miR-320d was down-regulated in chordoma tissue compared to fetal nucleus pulposus.
genetics_knock down_promote	34720057	hsa-mir-20a	Retinoblastoma	Downregulation of miR-320a obviously attenuated the inhibitory effects of knockdown of FTX in RB malignant phenotypes, and knockdown of WNK1 also reversed the impacts of miR-320a inhibitor on malignant phenotypes. Our results revealed that FTX promoted RB progression by targeting the miR-320a/WNK1 axis (graphical abstract), suggesting that FTX might be a novel therapeutic target for RB.
genetics_overexpression_promote	34720052	hsa-mir-149	Carcinoma, Hepatocellular	Besides, the rescue experiments were performed by co-transfection with cric_0011385 overexpression plasmid, si-cric_0011385, miR
lncRNA target	34720049	hsa-mir-214	Urinary Bladder Neoplasms	In conclusion, YY1-induced PSMA3-AS1 exerted an oncogenic function in BC cells via targeting miR
lncRNA target	34719830	hsa-mir-381	Thyroid Carcinoma, Anaplastic	3p and HOXA9 may be promising molecular targets for preventing ATC progression and drug resistance.
circulation_biomarker_diagnosis_up	34719421	hsa-mir-138	cough variant asthma	OBJECTIVES: To study the expression levels of microRNA-138 (miR-138) and Runt-related transcription factor 3 (RUNX3) in peripheral blood of children with cough variant asthma (CVA) and their regulatory effects on Th1/Th2 balance.
genetics_knock down_promote	34719417	hsa-mir-506	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The multivariate COX regression analysis showed that leukocyte count 50109/L, medium-high risk stratification, MLL gene rearrangement, miR-9221.46, and miR-5062.17 could indicate poor prognosis in children with ALL (P<0.05).
genetics_knock down_promote	34719417	hsa-mir-922	Precursor Cell Lymphoblastic Leukemia-Lymphoma	The multivariate COX regression analysis showed that leukocyte count 50109/L, medium-high risk stratification, MLL gene rearrangement, miR-9221.46, and miR-5062.17 could indicate poor prognosis in children with ALL (P<0.05).
genetics_overexpression_promote	34719318	hsa-mir-7	Glioma	miR-7 overexpression inhibited cell viability, invasion, and colony formation ability via reducing CDK4 in glioma cells.
circulation_biomarker_diagnosis_up	34719090	hsa-mir-193b	Angelman Syndrome	The expressions of miR-193b-3p in the serum of AS patients were detected.
other	34718921	hsa-mir-506	Insulin Resistance	3p altered IR in adipocytes by regulating S6K1-mediated PI3K/AKT pathway activation.
genetics_overexpression_promote	34718359	hsa-mir-181a	Multiple Myeloma	CONCLUSIONS: CD138+ overexpression of miR-181a was strongly correlated with inferior disease outcome and contributed to superior prediction of MM patients early progression, supporting personalised prognosis and treatment decisions.
other	34718338	hsa-mir-106a	Bone Neoplasms	These findings demonstrated that restoring the expression of TP53INP1 by silencing miR-106a may be a novel therapeutic strategy for bone metastatic in lung adenocarcinoma.
other	34718338	hsa-mir-106a	Lung Neoplasms	These findings demonstrated that restoring the expression of TP53INP1 by silencing miR-106a may be a novel therapeutic strategy for bone metastatic in lung adenocarcinoma.
exosome	34718264	hsa-mir-149	Bipolar Disorder	Because miR-149 has been shown to inhibit glial proliferation, we hypothesized that increased miR-149 expression in BA24-derived exosomes may be consistent with the previously reported reduced glial cell numbers in BA24 of patients diagnosed with familial BD.
other	34718247	hsa-mir-128	Hypoxia-Ischemia, Brain	3p/Bax/Akt/GSK-3beta axis.
lncRNA target	34718169	hsa-mir-194	Carcinoma, Hepatocellular	5p inhibitor reversed the suppressive effects of sh-LINC01006 on the proliferation, invasion, and migration abilities of HCC cells.
circulation_biomarker_diagnosis_up	34717969	hsa-mir-203	Diabetic Foot	Results showed that before NPWT, levels of hsa-miR-203 in peripheral plasma (P-miR-203) and wound margin tissue (T-miR-203) of DFU group were obviously increased compared to SUC group while expression of P-miR-203 decreased in NDFU group compared with NC group.
lncRNA target	34717922	hsa-mir-338	Neuralgia	While additional work is needed to confirm these findings, validated target analysis suggests a neuroprotective role of miR
lncRNA target	34717922	hsa-mir-338	Spinal Cord Injuries	While additional work is needed to confirm these findings, validated target analysis suggests a neuroprotective role of miR
other	34717910	hsa-mir-21	Pulmonary Arterial Hypertension	Cold exposure promoted a greater decrease in miR5p, Bmpr2, Smad5, Tgfbr2, and Smad3 mRNA expression in lungs of the MCT Cold group.
lncRNA target	34717732	hsa-mir-200b	Breast Neoplasms	RESULTS: Here we designate SE-lncRNAs RP11-379F4.4 and RP11-465B22.8 as potential markers of progression of DCIS to IDC through regulation of the expression of their neighboring genes (RARRES1 and miR-200b, respectively).
transcription factor target	34717687	hsa-mir-17	Retinoblastoma	Using TargetScan and the 3'-untranslated region luciferase reporter assays, we show that the direct target of miR-17 is the retinoblastoma gene (RB1), a gene that is pivotal to osteoblastic differentiation.
genetics_knock down_promote	34717683	hsa-mir-646	Osteosarcoma	CONCLUSION: Circ_0000006 knockdown promoted DOX-mediated effects on OS development by miR-646/BDNF pathway, which provided a theoretical basis in treating OS with DOX.
genetics_knock down_suppress	34717611	hsa-mir-138	Cystic Fibrosis	BACKGROUND: We previously reported that expression of a miR-138 mimic or knockdown of SIN3A in primary cultures of cystic fibrosis (CF) airway epithelia increased DeltaF508-CFTR mRNA and protein levels, and partially restored CFTR-dependent chloride transport.
lncRNA target	34717195	hsa-mir-192	Asthma	PTTG3P promoted progression of childhood asthma by targeting the miR
transcription factor target	34717064	hsa-mir-18a	Asthma	MiR-18a inhibits PDGF-BB-induced proliferation, migration and phenotypic conversion of ASMCs by inhibiting the PI3K/AKT pathway, thus attenuating airway remodeling in asthma.
circulation_biomarker_diagnosis_up	34716993	hsa-mir-146a	Rhinitis, Allergic	METHODS: Expression of miR-146a and STAT5b in peripheral blood mononuclear cells (PBMCs) and nasal mucosa from patients with AR was detected by qPCR and Western blotting.
lncRNA target	34716872	hsa-mir-224	Glioma	5p targeted CHSY1 and LINC01094 up-regulated CHSY1 by targeting miR
genetics_knock down_suppress	34716858	hsa-mir-874	Carcinoma, Ovarian Epithelial	3p was found in SKOV3-DDP cells; it was also in association with cisplatin-resistance in EOC cells.
circulation_biomarker_diagnosis_ns	34716815	hsa-mir-21	Heart Failure	It was successfully used to detect miRNA-21 directly in serum samples from heart failure patients without previous RNA extraction neither amplification process.
other	34716815	hsa-mir-21	Cardiovascular Diseases	A simple carbon nanodot-based electrogenerated chemiluminescence biosensor is described for sensitive and selective detection of microRNA-21 (miRNA-21), a biomarker of several pathologies including cardiovascular diseases (CVDs).
circulation_biomarker_diagnosis_ns	34716495	hsa-mir-21	Lung Neoplasms	Most importantly, this approach was successfully applied to the detection of plasma exosomal microRNA-21 in patients with lung cancer, and it is proposed that other targets can also be detected by changing the FAM-H1 and FAM-H2 corresponding to the target sequence.
other	34716428	hsa-mir-215	Obesity	Quantitative polymerase chain reaction (qPCR) demonstrated that expression of miR-31 and miR-215 was significantly (p < 0.05) higher, 143-fold and 15-fold respectively, in obese than in non-obese individuals.
other	34716428	hsa-mir-1	Obesity	Quantitative polymerase chain reaction (qPCR) demonstrated that expression of miR-31 and miR-215 was significantly (p < 0.05) higher, 143-fold and 15-fold respectively, in obese than in non-obese individuals.
circRNA target	34716323	hsa-mir-612	Carcinoma, Hepatocellular	In conclusion, CircETFA can increase the expression of CCL5 to promote the progression of HCC by sponging hsa-mir-612 and recruiting EIF4A3, and is promising as a novel biomarker and therapeutic target.
lncRNA target	34716310	hsa-mir-361	Osteosarcoma	3p/FZD4 axis plays an important role in OS progression and might be a potential therapeutic target.
other	34716304	hsa-mir-3175	Necrosis	Importantly, miR-3175 expression was decreased in necrotic femoral head tissues of dexamethasone-taking patients, where DCAF1 mRNA was upregulated.
genetics_overexpression_suppress	34716285	hsa-mir-1205	Osteosarcoma	Interestingly, overexpressed PTBP1 (or miR-1205 inhibition) reversed the inhibitory effects mediated by circFAM120B downregulation in OS cells.
other	34716242	hsa-mir-192	Glomerulonephritis, Membranous	RESULTS: Glomerular endothelial cell (GEC)-derived miR5p and podocyte-derived miR-378a-3p are upregulated in urine and glomeruli of patients with iMGN, whereas glomerular NPNT is reduced.
other	34716242	hsa-mir-378a	Glomerulonephritis, Membranous	RESULTS: Glomerular endothelial cell (GEC)-derived miR5p and podocyte-derived miR-378a-3p are upregulated in urine and glomeruli of patients with iMGN, whereas glomerular NPNT is reduced.
circulation_biomarker_diagnosis_up	34715911	hsa-mir-638	Diabetic Nephropathies	CONCLUSIONS: Serum miR-638 expression was low in DN and can be a potentially valuable biomarker for DN.
genetics_knock down_promote	34715859	hsa-mir-509	Carcinoma, Non-Small-Cell Lung	Knockdown of ASAP1-IT1 or overexpression of miR
genetics_knock down_promote	34715856	hsa-mir-124	Stomach Neoplasms	Through overexpression/knockdown experiments and function tests in vitro, we demonstrated HOXA11-AS can promote ITGB3 expression by sponging miR
lncRNA target	34715819	hsa-mir-545	Stomach Neoplasms	CONCLUSION: LINC00342 plays a potential oncogenic role in GC by targeting the miR545-5p/CNPY2 axis, and might act as a novel therapeutic target for GC.
genetics_overexpression_promote	34715618	hsa-mir-192	Arthritis, Gouty	5p overexpression induced by miR
transcription factor target	34715574	hsa-mir-124	Rhinitis, Allergic	3p /DPP4 axis may be an attractive target for AR therapy.
exosome	34715573	hsa-mir-98	Myocardial Reperfusion Injury	CONCLUSION: Hypoxia-induced BMSC-exos elevated miR
genetics_overexpression_promote	34715498	hsa-mir-361	Arthritis, Rheumatoid	By qRT-PCR, GAS5 and PDK4 were found to be overexpressed in synovial tissue, fibroblast-like synoviocytes of RA patients and LPS-induced chondrocytes, while the miR
genetics_overexpression_promote	34715270	hsa-mir-214	Alzheimer Disease	5p and down-regulated SUZ12, and the overexpression of miR
genetics_overexpression_promote	34715270	hsa-mir-214	Nerve Degeneration	5p and down-regulated SUZ12, and the overexpression of miR
other	34714963	hsa-mir-125a	Glioma	CONCLUSIONS: LncRNA MIR4435-2HG obstructs the functions of miR-125a-5p and promotes neuroglioma development by upregulating the TAZ gene.
genetics_overexpression_promote	34714955	hsa-mir-423	Adenocarcinoma of Lung	3p overexpression could rescue the impairment of LUAD cell proliferation, invasion, adhesion, and EMT caused by CYBRD1 depletion.
genetics_GWAS	34714557	hsa-mir-9	Vitiligo	To conduct a clinical biochemical study that aids in investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, MALAT-1 and miR-9 in attempt to provide new diagnostic biomarkers in vitiligo patients for Egyptians. miR-9 as well as long non-coding MALAT-1 may be considered as biomarkers for vitiligo susceptibility which may provide a new direction for treatment.
genetics_knock down_promote	34713767	hsa-mir-7	Stomach Neoplasms	5p could restore cell function, EGFR expression of GC cells when linc00467 knockdown occurs.
genetics_GWAS	34713722	hsa-mir-223	Coronary Artery Disease	Conclusions GAS5 rs55829688 polymorphism might affect clopidogrel response in patients with CAD with the CYP2C19 poor metabolizer genotypes, and GAS5 regulates P2Y12 expression and clopidogrel response by acting as a competitive endogenous RNA for miR
lncRNA target	34713362	hsa-mir-7a	Diabetes Mellitus	Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study.
lncRNA target	34713362	hsa-mir-7	Diabetes Mellitus	Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study.
lncRNA target	34713362	hsa-mir-7a	Metabolic Diseases	Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study.
lncRNA target	34713362	hsa-mir-7	Metabolic Diseases	Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study.
transcription factor target	34713306	hsa-mir-483	Dermatitis, Atopic	The high dose MSC treatment is efficacious in alleviating the clinical signs of cAD until 30 days after the last subcutaneous administration of MSCs, and miRNA-483 may be a reliable prognostic biomarker for cAD.
lncRNA target	34713296	hsa-mir-133a	Breast Neoplasms	miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them.
lncRNA target	34713296	hsa-mir-223	Breast Neoplasms	miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them.
lncRNA target	34713296	hsa-mir-16	Breast Neoplasms	miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them.
genetics_knock down_promote	34713294	hsa-mir-203	Hemangioma	Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR203induced mediation of the Notch signaling pathway. In conclusion, the findings of the present study suggested that lncRNA MEG8 knockdown may inhibit cell proliferation and invasion, but promote cell apoptosis in hemangioma via miR203induced mediation of the Notch signaling pathway.
circulation_biomarker_diagnosis_ns	34712934	hsa-mir-181b	Fibrosis	Conclusions Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development.
circulation_biomarker_diagnosis_ns	34712934	hsa-mir-181b	Ascites	Conclusions Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development.
other	34712662	hsa-mir-493	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-3168	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-370	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-2110	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-409	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-122	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-654	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-215	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-335	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-483	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-381	Atherosclerosis	5p for peripheral arterial disease.
other	34712662	hsa-mir-199a	Atherosclerosis	5p for peripheral arterial disease.
lncRNA target	34712659	hsa-mir-30	Reperfusion Injury, Cerebral Ischemia	Furthermore, the results showed that miR5p targeted TLR4, which was also upregulated in the infarcted area of MCAO/IR rats and OGD/R PC12 cells.
lncRNA target	34712602	hsa-mir-146a	Squamous Cell Carcinoma of Head and Neck	Collectively, our study demonstrates that miR-146a regulates CSCs in OSCC through CD24-AKT-beta-catenin axis.
lncRNA target	34712553	hsa-mir-193a	Chordoma	Therefore, it was concluded that lncRNA KRT8P41, miR-193a-3p, and FUBP1 form a lncRNA-miRNA-mRNA axis, modulating the proliferation and invasion of chordoma cells.
other	34712495	hsa-mir-195	cone-rod dystrophy 6	Results from the experiments manifested upregulated levels of SNHG1 and VEGF-A in HUVECs and CRNV tissues as compared with the control group, whereas downregulated levels of miR5p were measured in the CRNV tissues and HUVECs, suggesting the negative correlation between lncRNA and miRNA.
lncRNA target	34712388	hsa-mir-152	Myocardial Infarction	circRNA1615 inhibited ferroptosis in cardiomyocytes, and circRNA1615 could regulate the expression of LRP6 through sponge adsorption of miR
lncRNA target	34712356	hsa-mir-424	Glioma	5p/FAM87A on glioma cells were identified via the cell function experiments.
other	34712340	hsa-mir-338	Nasopharyngeal Carcinoma	3p and the high expression of STAT3 in NPC, which are all related to the TNM stage, T stage, and prognosis of the patient.
exosome	34712334	hsa-mir-141	Osteoporosis	KCNQ1OT1-Exos have a more significant inhibitory effect compared to ADSCs-Exos by the function of sponging miR5p, suggesting that KCNQ1OT1-Exos can be promising agents in osteoporosis treatment.
target gene	34712324	hsa-mir-149	Stomach Neoplasms	SLCO4A1-AS1 Facilitates the Malignant Phenotype via miR-149-5p/STAT3 Axis in Gastric Cancer Cells.
target gene	34712060	hsa-mir-382	Liver Neoplasms	miRNA-382-5p Suppresses the Expression of Farnesoid X Receptor to Promote Progression of Liver Cancer.
other	34711961	hsa-mir-181	Amyotrophic Lateral Sclerosis	miRbased ALS biomarkers encourage additional validation and might enhance the power of clinical trials.
transcription factor target	34711123	hsa-mir-375	Retinoblastoma	CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy.
genetics_overexpression_suppress	34711122	hsa-mir-133b	Adenocarcinoma of Lung	Moreover, it was proved by the rescue assay that the overexpression of miR-133b significantly downregulated SKA3 in LUAD cells.
other	34711117	hsa-mir-590	Breast Neoplasms	These data suggest that the CASC9/miR3p/SIX1/NF-kappaB axis is involved in breast cancer progression, providing insight into the function of CASC9 in breast cancer development.
lncRNA target	34710881	hsa-mir-223	Acute Kidney Injury	3p via binding to the miR
lncRNA target	34710881	hsa-mir-223	Spinal Cord Injuries	3p via binding to the miR
transcription factor target	34710568	hsa-mir-222	Tuberculosis	These results uncover an ESAT6 dependent role for miR3p and its target PTEN in regulating host immune responses to bacterial infection and may provide a potential site for the development of anti-tuberculosis drugs that specifically antagonize the virulence of ESAT6.
transcription factor target	34710568	hsa-mir-222	Drug Hypersensitivity	These results uncover an ESAT6 dependent role for miR3p and its target PTEN in regulating host immune responses to bacterial infection and may provide a potential site for the development of anti-tuberculosis drugs that specifically antagonize the virulence of ESAT6.
circulation_biomarker_diagnosis_ns	34710223	hsa-mir-191	Moebius syndrome 1	Thus, this study measured the expression of miRNA-93 and -191 in the serum of adults with MBT and examined the correlations of Injury Severity Score (ISS) and Revised Trauma Score values with serum miRNA-93 and -191 levels in these patients with the aim of predicting trauma severity based on the miRNA levels.
circulation_biomarker_diagnosis_up	34710223	hsa-mir-191	Multiple Trauma	In the patients with multitrauma, ISS was significantly, negative and weak correlated with serum miRNA-191 level (rho=-0.320, p=0.023) but not with the serum miRNA-93 level.
circulation_biomarker_diagnosis_ns	34710223	hsa-mir-93	Moebius syndrome 1	Thus, this study measured the expression of miRNA-93 and -191 in the serum of adults with MBT and examined the correlations of Injury Severity Score (ISS) and Revised Trauma Score values with serum miRNA-93 and -191 levels in these patients with the aim of predicting trauma severity based on the miRNA levels.
circulation_biomarker_diagnosis_ns	34710223	hsa-mir-93	Multiple Trauma	In the patients with multitrauma, ISS was significantly, negative and weak correlated with serum miRNA-191 level (rho=-0.320, p=0.023) but not with the serum miRNA-93 level. The level of miRNA-191 in conjunction with ISS, but not that of miRNA-93, may be a useful biomarker for determining injury severity in patients with multitrauma.
circulation_biomarker_diagnosis_up	34710223	hsa-mir-191	Wounds and Injuries	However, an optimal cutoff value for serum miRNA-191 was identified, with values <1.94 indicating severe trauma (AUC 0.668 [0.511-0.826]; 65.6% sensitivity, 77.8% specificity).
circulation_biomarker_diagnosis_ns	34710223	hsa-mir-93	Wounds and Injuries	No optimal cutoff for the serum miRNA-93 level was found with respect to trauma severity (AUC 0.617, [0.455-0.779]).
lncRNA target	34709983	hsa-mir-497	Glioma	5p expression, showing its potential as a prognostic biomarker and a therapeutic target for glioma.
exosome	34709978	hsa-mir-125a	Osteoarthritis	All these outcomes revealed that BMSCs-derived exosomal miR-125a-5p is a positive regulator for chondrocyte migration and inhibit cartilage degeneration We thus were reasonable to believe that transferring of exosomal miR-125a-5p is a prospective strategy for OA treatment.
genetics_overexpression_promote	34709968	hsa-mir-194	Carcinoma, Non-Small-Cell Lung	Pulmonary function tests (PETs) revealed that knocking down circSOX13 or overexpressing miR
genetics_overexpression_promote	34709954	hsa-mir-10b	Rhinitis, Allergic	CONCLUSION: The present study demonstrates that MIAT overexpression Promotes allergic inflammation and symptoms by activating Th17 immune response via miR-10b-5p inhibition.
genetics_overexpression_promote	34709954	hsa-mir-10b	Allergic Inflammation	CONCLUSION: The present study demonstrates that MIAT overexpression Promotes allergic inflammation and symptoms by activating Th17 immune response via miR-10b-5p inhibition.
genetics_overexpression_promote	34709725	hsa-mir-491	Leukemia, Myeloid, Acute	5p overexpression-mediated influences in AML cells were effectually overturned by the addition of B4GALT5 overexpression plasmid.
other	34709686	hsa-mir-378	Spinal Cord Injuries	3p in model rats with contusion SCI improved neurological and motor functions.
lncRNA target	34709546	hsa-mir-567	Ovarian Neoplasms	circ_0000554 promoted ovarian tumor cell growth, invasion, and EMT via sponging miR-567.
lncRNA target	34709490	hsa-mir-499	Subarachnoid Hemorrhage	Our study demonstrates that silencing of MALAT1 alleviates neurocyte apoptosis and reduces ROS production through the miR5p/SOX6 axis after SAH injury.
lncRNA target	34708894	hsa-mir-125a	Arthritis, Rheumatoid	CONCLUSION: lnc-NEAT1 and its targets (miR-21 and miR-125a) correlate with RA risk and disease activity, and declined lnc-NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc-NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA.
lncRNA target	34708894	hsa-mir-21	Arthritis, Rheumatoid	CONCLUSION: lnc-NEAT1 and its targets (miR-21 and miR-125a) correlate with RA risk and disease activity, and declined lnc-NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc-NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA.
genetics_overexpression_promote	34708891	hsa-mir-125a	Stomach Neoplasms	Finally, miR-125a-5p was overexpressed in late-stage GCs, and positive correlations were observed with its targets EphA2, TAZ, and TEAD2.
circulation_biomarker_prognosis_ns	34708885	hsa-mir-210	Ischemic Stroke	CONCLUSIONS Serum miR-210 is a weak diagnostic marker of IS.
lncRNA target	34708859	hsa-mir-222	Thyroid Cancer, Papillary	3p can promote the proliferation, migration and invasion of PTC cells through targeting SLC4A4.
transcription factor target	34708638	hsa-mir-346	Thyroiditis, Autoimmune	5p, then act on their target genes to immune and inflammation-related pathways, which may be one of the mechanisms of HPM on EAT rats.
transcription factor target	34708638	hsa-mir-31	Thyroiditis, Autoimmune	5p, then act on their target genes to immune and inflammation-related pathways, which may be one of the mechanisms of HPM on EAT rats.
genetics_knock down_promote	34708547	hsa-mir-374b	Melanoma	Functionally, UHMK1 overexpression or miR-374b-5p knockdown reversed the suppressive effect of BLACAT1 depletion on melanoma cell proliferation and invasion.
lncRNA target	34708454	hsa-mir-130a	Craniocerebral Trauma	BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases.
lncRNA target	34708454	hsa-mir-130a	Chronic Disease	BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases.
lncRNA target	34708454	hsa-mir-130a	Mycobacterium avium-intracellulare Infection	Furthermore, high miR-130a expression at M0, M12, and M36 was significantly correlated with prolonged MACCE-free survival in ESRD patients undergoing CAPD (all p < 0.05), and high miR-130a expression at M0 was an independent factor for improved MACCE-free survival (p = 0.015; hazard ratio (HR) (95% confidential interval): 0.456 (0.243-0.857)).
lncRNA target	34708454	hsa-mir-130a	Vascular Diseases	BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases.
circulation_biomarker_diagnosis_ns	34708454	hsa-mir-130a	Kidney Failure, Chronic	METHODS miR-130a expression in peripheral blood mononuclear cells obtained from 50 healthy controls (HCs) at recruitment and 257 ESRD patients undergoing CAPD at month (M)0, M12, M24, and M36 was determined by reverse transcription-quantitative polymerase chain reaction.
lncRNA target	34708395	hsa-mir-370	Prostatic Neoplasms	In summary, our study showed that lncRNA HCG18 accelerated cell proliferation, invasion, and migration of PC via up-regulating DDX3X through sponging miR
lncRNA target	34708341	hsa-let-7c	Carcinoma, Transitional Cell	CONCLUSIONS: Our results demonstrate that miR-Let-7c can act in different pathways of the carcinogenic cellular processes of muscle-invasive urothelial carcinoma cells, inhibiting cell proliferation and increasing apoptosis levels, consequently limiting their invasion potential.
exosome	34708038	hsa-mir-193a	Nephrotic Syndrome	Higher Urine Exosomal miR-193a Is Associated With a Higher Probability of Primary Focal Segmental Glomerulosclerosis and an Increased Risk of Poor Prognosis Among Children With Nephrotic Syndrome.
genetics_overexpression_promote	34707707	hsa-mir-216a	Wounds and Injuries	The present study aimed to investigate the role of miR-216a-5p in lipopolysaccharide (LPS)-induced endothelial injury in vitro. Taken together, the results suggest that overexpression of miR-216a-5p suppresses the effects of LPS induced endothelial injury.
transcription factor target	34707706	hsa-mir-142	Mastitis	5p may promote the progression of bovine mastitis via targeting BAG5.
target gene	34707704	hsa-mir-106a	Adenocarcinoma of Lung	MicroRNA-106a-5p promotes the proliferation, autophagy and migration of lung adenocarcinoma cells by targeting LKB1/AMPK.
genetics_overexpression_suppress	34707683	hsa-mir-18a	Squamous Cell Carcinoma of Head and Neck	Rescue experiments displayed that forced expression of SORBS2 restored the impact of miR-18a-5p overexpression on HNSCC cells.
other	34707644	hsa-let-7e	Diabetes Mellitus, Type 2	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
other	34707644	hsa-mir-342	Diabetes Mellitus, Type 2	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
other	34707644	hsa-mir-342	Erectile Dysfunction, Diabetic	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
other	34707644	hsa-let-7e	Erectile Dysfunction, Diabetic	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
other	34707644	hsa-mir-199b	Erectile Dysfunction, Diabetic	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
other	34707644	hsa-mir-199b	Diabetes Mellitus, Type 2	Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4.
lncRNA target	34707383	hsa-mir-4524a	Atherosclerosis	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707383	hsa-mir-4524a	Coronary Artery Disease	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707383	hsa-mir-548	Atherosclerosis	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707383	hsa-mir-671	Coronary Artery Disease	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707383	hsa-mir-548	Coronary Artery Disease	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707383	hsa-mir-671	Atherosclerosis	The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV).
lncRNA target	34707022	hsa-mir-515	Breast Neoplasms	In summary, this study shows that circ_0103552 up-modulates CYR61 expression by targeting miR
other	34706869	hsa-mir-206	Carcinoma, Hepatocellular	MicroRNA-206, by driving M1 polarisation of KCs, promoted the recruitment of CD8(+) T cells and prevented HCC, suggesting its potential use as an immunotherapeutic approach.
other	34706799	hsa-mir-5590	Nasopharyngeal Carcinoma	SNHG14-miR 3p-ZEB1 positively regulated PD-L1 and facilitate the EMT of NPC.
other	34706761	hsa-mir-200	Colorectal Neoplasms	Testing of paired CRC patient samples confirmed the positive regulatory relationship between MYSM1 and miR-200/CDH1.
genetics_GWAS	34706712	hsa-mir-146a	Diabetes Mellitus, Type 2	RESULTS: There were no significant differences in the genotype or allele frequencies of the miR-146a polymorphism (rs2910164) between subjects with PDR and those without DR.
genetics_GWAS	34706712	hsa-mir-146a	Diabetic Retinopathy	RESULTS: There were no significant differences in the genotype or allele frequencies of the miR-146a polymorphism (rs2910164) between subjects with PDR and those without DR.
circulation_biomarker_diagnosis_up	34706645	hsa-mir-195	Colonic Neoplasms	5p in cytoplasm.
genetics_GWAS	34706275	hsa-mir-3682	Carcinoma, Hepatocellular	CONCLUSIONS: This study implicates that miR-3682 plays an oncogenetic role in HCC and can be considered a novel therapeutic target and prognostic indicator of HCC.
genetics_knock down_suppress	34706132	hsa-mir-512	Adenocarcinoma of Lung	5p inhibition could reverse the effects of hsa_circ_0005576 knockdown in LUAD cells resistant to osimertinib.
circRNA target	34705617	hsa-mir-214	Carcinoma, Renal Cell	Thus, hsa_circ_0065217/miR3p/ALPK2 signaling putatively promotes RCC tumorigenesis and is a putative RCC treatment target.
other	34705586	hsa-mir-19b	Mobility Limitation	The combine results of these three models identify miR-19b-3p as a potent regulator of muscle anabolism that may contribute to an inter-individual response to PRET in mobility-limited older adults.
transcription factor target	34705345	hsa-mir-124	Angelman Syndrome	The miR3p/DLX5 axis might serve as a therapeutic molecular target to reverse the effect of ox-LDL and prevent atherosclerosis (AS) development and progression.
transcription factor target	34705345	hsa-mir-124	Cell Transformation, Neoplastic	CONCLUSIONS The ox-LDL affects the VSMC proliferation/apoptosis balance via the miR3p/DLX5 axis, which results in VSMC hyperproliferation.
other	34705228	hsa-mir-1299	Adrenocorticotropic hormone deficiency	CircLIFR and KDR were down-regulated and miR-1299 was up-regulated in the artery wall tissues and ASMCs of IA patients. Our findings suggest that circLIFR, an underexpressed circRNA in IA, can regulate the proliferation, migration, invasion and apoptosis of HUASMCs depending on the miR-1299/KDR axis.
epigenetics	34705180	hsa-mir-132	Breast Neoplasms	3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test.
epigenetics	34705180	hsa-mir-129	Breast Neoplasms	3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test.
epigenetics	34705180	hsa-mir-148a	Breast Neoplasms	3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test.
epigenetics	34705180	hsa-mir-375	Breast Neoplasms	3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test.
genetics_overexpression_promote	34704918	hsa-mir-296	Uterine Cervical Neoplasms	5p counteracted the enhancing effects of overexpressed KCNQ1OT1 on the proliferative, migrative and invasive abilities of CC cells.
genetics_overexpression_promote	34704819	hsa-mir-188	Carcinoma, Hepatocellular	MiR-3188 overexpression promoted cell viability and proliferation but inhibited the apoptosis of HCC cells.
lncRNA target	34704657	hsa-mir-53	Sjogren's Syndrome	RESULTS: We successfully generated SSB-resistant rice (csu-53) expressing the artificial microRNA (amiRNA) of SSB endogenous miRNA (csu-novel-miR53) through the RNAi-based technology. CONCLUSION: amiRNA-mediated strategy can be applied to the development of insect-resistant crops, and the novel amiRNA csu-novel-miR53 of SSB has important application potential in developing SSB resistant rice.
genetics_overexpression_promote	34704601	hsa-mir-423	Colonic Neoplasms	Intriguingly, overexpression of MFAP2 restrained si-KCNQ1OT1- or miR
genetics_knock down_promote	34704451	hsa-mir-1301	Thyroid Cancer, Papillary	3p overexpression inhibited the malignant effects of PTC cells via suppressing HMGB1.
genetics_knock down_promote	34704358	hsa-mir-150	Diabetes Mellitus	We further delineated the critical cellular localization of phosphorylated ELK1 at serine 383 (pELK1(S383) ) and found that decreased miR-150 exacerbated the T2D-induced inflammation in photoreceptors by upregulating ELK1 and pELK1(S383) , and knockdown of ELK1 alleviated PA-elicited photoreceptor inflammation.
lncRNA target	34704284	hsa-mir-377	Hernias, Diaphragmatic, Congenital	Expression of Concern: 'miR3p drives malignancy characteristics via upregulating GSK-3beta expression and activating NF-kappaB pathway in hCRC cells', by Wei-Ying Liu, Zhen Yang, Qi Sun, Xi Yang, Yang Hu, Hong Xie, Hui-Jie Gao, Li-Ming Guo, Jian-Ying Yi, Min Liu, and Hua Tang (2017); J Cell Biochem.
transcription factor target	34704004	hsa-mir-138	Hepatitis B, Chronic	Thus, inhibiting hsa-miR5p expression should be considered in the combinatorial design of new therapies against HBV, especially in the context of immune-mediated A3B induction.
genetics_knock down_promote	34703899	hsa-mir-34b	Carcinoma, Endometrioid	Lastly, knockdown of miR-34b counteracted with the suppressive effects of ZFAS1 silence on endometrial carcinoma cell proliferation and metastasis.
lncRNA target	34703677	hsa-mir-155	Glomerulonephritis, Membranous	RESULTS: Two miRNA-mRNA pairs, miR5p-FOS and miR-146a-5p-BTG2, were differentially expressed in IMN, indicating that these genes may affect IMN through immune processes.
lncRNA target	34703677	hsa-mir-146a	Glomerulonephritis, Membranous	RESULTS: Two miRNA-mRNA pairs, miR5p-FOS and miR-146a-5p-BTG2, were differentially expressed in IMN, indicating that these genes may affect IMN through immune processes.
other	34703649	hsa-mir-370	Carcinoma, Hepatocellular	In addition, we demonstrated that circHPS5 can act as a miR-370 sponge to regulate the expression of HMGA2 and further accelerate HCC cell tumorigenesis.
other	34703648	hsa-mir-16-1	Urinary Bladder Neoplasms	1-3p/MDM2/p53 axis.
other	34703647	hsa-mir-146b	Adenocarcinoma of Lung	RNA precipitation assays, western blotting, luciferase assays, and rescue experiments demonstrated that HIF1A-AS2 sponged microRNA-146b-5p (miR-146b-5p), promoting interleukin-6 (IL-6) expression, activating the IL-6/STAT3 pathway, and leading to LUAD progression. miR-146b-5p and IL-6 levels were correlated with the prognosis of LUAD patients.
genetics_overexpression_promote	34703308	hsa-mir-10a	Urinary Bladder Neoplasms	In addition, overexpression of miR-10a-5p could promote BCa cell proliferation, migration, and invasion.
other	34703286	hsa-mir-1245a	Sarcopenia	CONCLUSION: Our analyses indicate that miRNA-1245a may be a potential key molecule in the diagnosis and treatment of sarcopenia, which provides a basis for the research of miRNA in sarcopenia.
transcription factor target	34703270	hsa-mir-155	Asthma	CONCLUSION: SJMHE1 regulated the balance of Th17 and Treg cells by modulating the activation of STAT3 and STAT5 via miR-155 in asthma.
circulation_biomarker_prognosis_up	34703259	hsa-mir-34c	Diabetes Mellitus, Type 2	CONCLUSION: The increased expression of miR-34c in peripheral blood of T2DM patients is closely related to the occurrence, development and prognosis of DFU and DFO.
circulation_biomarker_prognosis_up	34703259	hsa-mir-34c	Diabetic Foot	CONCLUSION: The increased expression of miR-34c in peripheral blood of T2DM patients is closely related to the occurrence, development and prognosis of DFU and DFO.
transcription factor target	34703235	hsa-mir-448	Brain Ischemia	3p participated in the regulation of cerebral I/R injury via inhibiting Nrf2.
epigenetics	34702271	hsa-mir-23b	Squamous Cell Carcinoma of Head and Neck	Hypomethylation and downregulation of miR-23b-3p might account for the oncogenic role of PLAU in HNSCC.
lncRNA target	34702201	hsa-mir-490	Urinary Bladder Neoplasms	CONCLUSIONS: Our study revealed that LINC00958 facilitated cell proliferation and invasion, and suppressed cell apoptosis by sponging miR
circulation_biomarker_diagnosis_down	34702176	hsa-mir-375	Carotid Stenosis	RESULTS The expression level of serum miR
circulation_biomarker_prognosis_up	34702084	hsa-mir-124	Cerebral Infarction, Acute	miR-124 was poorly expressed in the serum of ACI patients and served as a biomarker for the diagnosis and prognosis.
genetics_overexpression_suppress	34699986	hsa-mir-221	Carcinoma, Hepatocellular	Overexpressing miR
other	34699756	hsa-mir-22	Atherosclerosis	Collectively, SNHG16 accelerated atherosclerotic plaque (AP) formation and enhanced ox-LDL-activated VSMCs proliferation and migration by miRNA3p/HMGB2 axis.
lncRNA target	34699621	hsa-mir-21	Carcinoma, Renal Cell	Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells.
lncRNA target	34699621	hsa-mir-765	Carcinoma, Renal Cell	Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells.
lncRNA target	34699621	hsa-mir-144	Carcinoma, Renal Cell	Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells.
lncRNA target	34699325	hsa-mir-934	Colorectal Neoplasms	In summary, this study suggests that miR-934 facilitates CRC progression by targeting BTG2, and further highlights the role of miR-934 in pathogenesis of CRC.
genetics_knock down_promote	34699320	hsa-mir-375	Esophageal Squamous Cell Carcinoma	Further study showed that sestrin 3 (SESN3) could interact with miR-375, and its knockdown annulled the stimulative effect of miR-375 inhibitor on ESCC development.
genetics_overexpression_promote	34699315	hsa-mir-4521	Breast Neoplasms	Overexpression of miR-4521 suppressed the growth, migration, invasion and cell cycle progression of BC cells and restrained p65 expression; downregulation of miR-4521 in BC cells showed opposite biological effects.
lncRNA target	34699311	hsa-mir-335	Asthma	5p alleviate inflammatory response, airway fibrosis, and autophagy in childhood asthma through targeted regulation of ATG5.
lncRNA target	34699311	hsa-mir-335	Fibrosis, Airway	5p alleviate inflammatory response, airway fibrosis, and autophagy in childhood asthma through targeted regulation of ATG5.
other	34698882	hsa-mir-409	Obesity	3p as a critical regulator of EC-BAT crosstalk by modulating a ZEB1-MAP4K3-PLGF signaling axis, providing new insights for therapeutic intervention in obesity.
circulation_biomarker_diagnosis_ns	34698812	hsa-mir-1246	Dermatomyositis	DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage.
circulation_biomarker_diagnosis_ns	34698812	hsa-mir-125a	Dermatomyositis	DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage.
circulation_biomarker_diagnosis_ns	34698812	hsa-mir-614	Dermatomyositis	DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage.
circulation_biomarker_diagnosis_ns	34698413	hsa-mir-21	Encephalitis, Japanese	We have found significantly altered expression of miR-155 and miR-21 in serum of JEV infected patients as compared to healthy controls, revealing their role as a a noninvasive biomarker in JE.
circulation_biomarker_diagnosis_ns	34698413	hsa-mir-155	Encephalitis, Japanese	We have found significantly altered expression of miR-155 and miR-21 in serum of JEV infected patients as compared to healthy controls, revealing their role as a a noninvasive biomarker in JE.
lncRNA target	34698372	hsa-mir-185	Asthma	5p is a modulator of periostin secretion by airway structural cells and of smooth muscle contraction, which can be related to asthma pathophysiology, and thus, might be a promising therapeutic target.
lncRNA target	34698362	hsa-mir-223	Atrial Fibrillation	A ceRNA regulatory relationship may exist between KCNQ1OT1 and miR2233p in AF, providing therefore a novel potential research target for further studies.
lncRNA target	34698360	hsa-mir-18a	Lymphoma, Large B-Cell, Diffuse	On the whole, the present study demonstrates that GAS5 functions as a ceRNA, inhibiting DLBCL cell proliferation by sponging miR18a5p to upregulate RUNX1 expression.
transcription factor target	34698359	hsa-mir-149	Prostatic Neoplasms, Castration-Resistant	The miR149/Akt1/AR regulatory pathway may represent a novel PCa therapeutic target.
other	34698358	hsa-mir-195	Prostatic Neoplasms	Furthermore, miR1955p may regulate PCa cell proliferation and invasion by regulating MIB1, indicating its potential therapeutic application for PCa in the future.
genetics_knock down_promote	34698001	hsa-mir-218	Squamous Cell Carcinoma of Head and Neck	5p reversed the inhibitory effect of HOXA-AS3 knockdown on the proliferative potential of OSCC cells.
genetics_knock down_promote	34698000	hsa-mir-409	Breast Neoplasms	In addition, overexpression of circCNOT2 or TWIST1 accelerated BC invasion, migration and EMT, which could be reversed by simultaneous transfection of miR
lncRNA target	34697900	hsa-mir-212	Prostatic Neoplasms	Rescue experiments further showed that LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR5p/ FZD5/ Wnt/beta-catenin axis.
other	34697773	hsa-mir-7	Nerve Degeneration	Collectively, these findings support the potential of miR-7 as a disease modifying biologic agent for Parkinson's disease and related alpha-synucleinopathies.
lncRNA target	34697729	hsa-mir-337	Osteoarthritis	3p exerted a protective effect on FJOA rats by alleviating damage of rat synovial tissues, promoting cell apoptosis and repressing inflammatory response.
other	34697541	hsa-mir-138	Stomach Neoplasms	The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2.
lncRNA target	34697449	hsa-mir-199a	Carcinoma, Squamous Cell, Cutaneous	In conclusion, HOTAIR, by up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC.
other	34697403	hsa-mir-4458	Stomach Neoplasms	In conclusion, LINC00963 and miR-4458 are potential biomarkers for predicting the overall survival of gastric cancer patients.
lncRNA target	34697393	hsa-mir-181a	lung squamous cell carcinoma	DLX6-AS1 induced by H3K4me1 played an important role in promoting secondary cisplatin resistance of LUSC through regulating the miR-181a-5p/miR
lncRNA target	34697393	hsa-mir-382	lung squamous cell carcinoma	DLX6-AS1 induced by H3K4me1 played an important role in promoting secondary cisplatin resistance of LUSC through regulating the miR-181a-5p/miR
lncRNA target	34696938	hsa-mir-29c	Oral Submucous Fibrosis	The purpose of the study is to investigate the functional role of miR-29c and its target in OSF.
other	34696757	hsa-mir-184	Shoulder Injuries	RESULTS: Microarray and qPCR analyses showed that miR-184 and miR-203 were expressed significantly more highly in tears than in sera (165,542.8- and 567.8-fold, respectively, p < 0.05).
lncRNA target	34696757	hsa-mir-203	Shoulder Injuries	RESULTS: Microarray and qPCR analyses showed that miR-184 and miR-203 were expressed significantly more highly in tears than in sera (165,542.8- and 567.8-fold, respectively, p < 0.05). CONCLUSIONS: In this study, we identified miRNAs that are highly expressed in tears, and the inhibition of miR-203 increases the viability of corneal epithelial cells.
transcription factor target	34696703	hsa-mir-34	Cholesteatoma, Middle Ear	It can passively target tumor tissue through EPR effect, and play its regulatory role on miR-34a, thus inhibiting the growth of cholesteatoma cells.
transcription factor target	34696703	hsa-mir-34a	Cholesteatoma, Middle Ear	It can passively target tumor tissue through EPR effect, and play its regulatory role on miR-34a, thus inhibiting the growth of cholesteatoma cells.
lncRNA target	34696702	hsa-mir-485	Pre-Eclampsia	In conclusion, silencing of NEAT1 promoted Treg/Th17 balance via the miR5p/AIM2 axis in PE, suggesting that NEAT1 is a potential target for the treatment of PE.
genetics_overexpression_promote	34696684	hsa-mir-4423	Arthritis, Rheumatoid	The overexpression of miR
circulation_biomarker_diagnosis_up	34696681	hsa-mir-138	Stomach Neoplasms	5p to upregulate PLAU could contribute to GAC progression, which might be useful for identifying biomarkers for GAC therapy.AbbreviationGastric adenocarcinoma (GAC); Long non-coding RNA (lncRNA); lncRNA TRPM2 antisense RNA (TRPM2-AS); Plasminogen Activator, Urokinase (PLAU); Wild-type (WT); mutant (MUT).
genetics_overexpression_promote	34696668	hsa-mir-150	Nasopharyngeal Neoplasms	The overexpression of hsa-miR
genetics_overexpression_promote	34696664	hsa-mir-145	Osteosarcoma	Our results demonstrate that the overexpression of lncRNA SOX21-AS1 up-regulates mTOR and KLF4 by sponging hsa-mir
genetics_overexpression_promote	34696664	hsa-mir-7	Osteosarcoma	Our results demonstrate that the overexpression of lncRNA SOX21-AS1 up-regulates mTOR and KLF4 by sponging hsa-mir
genetics_overexpression_promote	34696660	hsa-mir-130a	Stomach Neoplasms	While miR-130a-3p mimics facilitated cellular proliferation, migration, and invasion in vitro, promoted tumor growth in vivo, and activated the TGF-beta1/SMAD3 signaling pathway, overexpression of GCNT4 prevented the growth of gastric cancer cells and restrained the activation of the TGF-beta1/SMAD3 pathway.
transcription factor target	34696659	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	MiR-326 inhibited the proliferation of chemotherapy-resistant NSCLC cells and promoted their apoptosis by suppressing SIRT1.
circulation_biomarker_diagnosis_ns	34696438	hsa-mir-135a	Carcinoma, Hepatocellular	In conclusion: serum IL-13, Vitamin D, and miRNA-135a could be potential biomarkers in monitoring DAA treatment and HCC prediction.
genetics_knock down_promote	34695896	hsa-mir-367	Ovarian Neoplasms	Conclusion: Knockdown of circBIRC6 may inhibit the proliferation of ovarian cancer cisplatin-resistant cells and induce apoptosis by up-regulating the expression of miR
lncRNA target	34695805	hsa-mir-20a	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	We validated that the treatment of miR-20a-5p mimic inhibited the viability of T-ALL cells.
other	34695419	hsa-mir-27a	Neoplasms, Second Primary	Particularly, miR-27a-3p has been shown to play a critical role in the regulation of P-gp in multi-drug resistant cancer cells.
other	34695419	hsa-mir-27a	Brain Diseases	In brain disorders, altered levels of miR-27a-3p were reported in several diseases associated with alterations in P-gp expression at the BBB.
other	34695419	hsa-mir-27a	Central Nervous System Diseases	These findings shed light on miR-27a-3p/GSK3ss/ss-catenin as a novel axis that could be exploited to modulate P-gp efflux activity at the brain endothelium and help improving CNS diseases treatment or brain protection.
other	34695419	hsa-mir-27a	Genetic Diseases, Inborn	Particularly, miR-27a-3p has been shown to play a critical role in the regulation of P-gp in multi-drug resistant cancer cells.
other	34695392	hsa-mir-128	Diabetic Neuropathies	Based on these results, we speculated that a newly identified circRNA, circ-Nbea, may play an important role in the development of DE, and the mechanism is mediated by sponging miR3p.
other	34695390	hsa-mir-16	Liver Diseases	Here, we evaluated Cel-miR3p and miRNA16-5p as calibrator for the quantification of 15 miRNAs linked to hepatic impairment.
other	34695177	hsa-mir-143	Carcinoma, Non-Small-Cell Lung	These results demonstrated that the LINC01296/miR3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance.
other	34695034	hsa-mir-93	Crohn Disease	5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]).
other	34695034	hsa-mir-106b	Crohn Disease	5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]).
other	34695034	hsa-mir-451a	Crohn Disease	5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]).
other	34695034	hsa-mir-15b	Crohn Disease	5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]).
other	34695034	hsa-mir-191	Crohn Disease	5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]).
lncRNA target	34694758	hsa-let-7i	Acute Kidney Injury	In conclusion, miR-let-7i could be an interesting therapeutic target and nanoparticle-based DIO could be a potential candidate in the management of acute kidney injury.
exosome	34694648	hsa-mir-126	Wounds and Injuries	Rats with full-thickness skin defects were injected with ADSC-Exos or exosomes extracted from ADSCs transfected with miR
circRNA target	34694278	hsa-mir-409	Carcinoma, Non-Small-Cell Lung	3p inhibitors could partially reverse these impacts.
transcription factor target	34694211	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	3p may act as a potential therapeutic target for the treatment of NSCLC.
circRNA target	34693745	hsa-mir-6817	Bone Diseases	Collectively, circRFWD2/miR5p/BMPR2 axis could regulate DPSCs osteogenesis via BMP-Smad and p38 MAPK pathway, which are novel mechanisms in the osteogenic differentiation of DPSCs and suggest potential therapeutic methods for bone defects regeneration.
lncRNA target	34693428	hsa-mir-32	Bone Diseases	Compared with EMPs group, the expression of DSPP and DMP-1 and the number of mineralized nodules in EMPs+miR-32 inhibitor group were significantly reduced(P<0.05), while the expression of PPARgamma and C/EBPalpha and the number of lipid droplets were significantly increased(P<0.05).
genetics_overexpression_promote	34693046	hsa-mir-142	Squamous Cell Carcinoma of Head and Neck	Overexpression of miR
lncRNA target	34692852	hsa-mir-129	Uterine Cervical Neoplasms	5p/BST2 as a new potential target for cervical cancer.
other	34692839	hsa-mir-107	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-1304	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-216a	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-569	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-340	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-34a	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
other	34692839	hsa-mir-142	Familial Mediterranean Fever	5p were downregulated in the FMF patients.
genetics_overexpression_promote	34692524	hsa-mir-150	Osteosarcoma	Overexpression of miR
circulation_biomarker_diagnosis_up	34692511	hsa-mir-18a	Nasopharyngeal Carcinoma	METHODS: Expression levels of miR-18a-3p in platelets and plasma were detected by relative quantitative real-time PCR in NPC patients (n=54) and normal subjects (n=36).
genetics_overexpression_promote	34692507	hsa-mir-587	Stomach Neoplasms	Overexpression of circ-0002570 prevented VCAN from miR
transcription factor target	34692488	hsa-mir-183	Carcinoma, Renal Cell	5p/FOXO4 axis played essential role in promoting ccRCC progression, which suggests that disruption of this axis may be a potential therapeutic target in ccRCC.
circulation_biomarker_diagnosis_ns	34692473	hsa-mir-205	Carcinoma, Ovarian Epithelial	In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples.
circulation_biomarker_diagnosis_ns	34692473	hsa-mir-200c	Carcinoma, Ovarian Epithelial	In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples.
circulation_biomarker_diagnosis_ns	34692473	hsa-mir-141	Carcinoma, Ovarian Epithelial	In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples.
circulation_biomarker_diagnosis_up	34692380	hsa-mir-434	Sarcopenia	Circulating miR-21 levels were higher and miR-181a, miR-133a, miR
circulation_biomarker_diagnosis_up	34692380	hsa-mir-133a	Heart Failure, Chronic	METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR
circulation_biomarker_diagnosis_up	34692380	hsa-mir-133a	Sarcopenia	METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR
circulation_biomarker_diagnosis_up	34692380	hsa-mir-455	Sarcopenia	METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR
circulation_biomarker_diagnosis_up	34692380	hsa-mir-455	Heart Failure, Chronic	METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR
circulation_biomarker_diagnosis_up	34692380	hsa-mir-434	Heart Failure, Chronic	Circulating miR-21 levels were higher and miR-181a, miR-133a, miR
genetics_knock down_promote	34691259	hsa-mir-3907	Adenocarcinoma, Sebaceous, Eyelid	Furthermore, THBS1 overexpression was found to attenuate the stimulative effect of miR-3907 mimics, and THBS1-knockdown reversed the inhibitory effect of the miR-3907 inhibitor in SGC cells.
lncRNA target	34691252	hsa-mir-136	Endometrial Neoplasms	5p, which may improve the understanding of the roles of ncRNAs in EC, and may help identify novel targets for anticancer treatment.
exosome	34691188	hsa-mir-146a	Sepsis	CONCLUSION: This study suggests that miR-146a-5p-bearing MSC-derived exosomes may become an effective treatment for sepsis.
lncRNA target	34691176	hsa-mir-1278	Squamous Cell Carcinoma of Head and Neck	Mechanistically, circPTK2 functioned as a molecular sponge of miR-1278 to upregulate YAP1 expression in LSCC cells. Therefore, we concluded that circPTK2 facilitates LSCC progression through the miR-1278/YAP1 axis.
other	34691148	hsa-mir-124	Duane Retraction Syndrome	3p in high glucose (HG)-treated human retinal microvascular endothelial cells (HRMECs), an in vitro model of DR.
other	34691048	hsa-mir-26a	Diabetes Mellitus, Type 1	Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers.
other	34691048	hsa-mir-146a	Diabetes Mellitus, Type 1	Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers.
other	34691048	hsa-mir-24	Diabetes Mellitus, Type 1	Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers.
other	34690655	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	This study aims to examine the miR-31 expression in the pre- and post-operative OSCC patients and correlate this expression with clinicopathological characteristics. CONCLUSION: Our data suggest that miR-31 can be used as an adjunct non-invasive marker to monitor surgery outcomes during postoperative follow-up in patients with OSCC.
other	34690249	hsa-mir-140	Periodontitis	5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA.
other	34690249	hsa-mir-145	Periodontitis	5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA.
other	34690249	hsa-mir-146a	Periodontitis	5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA.
genetics_overexpression_suppress	34690112	hsa-mir-181b	Ovarian Neoplasms	The SCD1 overexpression and miR-181b-5p inhibitor could reverse exosomal SOX2-OT-mediated ovarian cancer progression.
genetics_overexpression_promote	34689819	hsa-mir-195	Thyroid Cancer, Papillary	5p overexpressed PTC cells and tumor xenografts, whereas CircRNA NRIP1 up-regulation overturned the impacts.
lncRNA target	34689806	hsa-mir-124	Glioma	3p/KIF20A nexus, thus providing novel predictive/prognostic biomarkers and drug targets against glioma.
exosome	34689803	hsa-mir-155	Multiple Myeloma	OBJECTIVE: This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells. CONCLUSION: Therefore, our findings indicate that exosomal delivery of miR-155 exerted the same effect as transfection did on the stemness maintenance and drug resistance of multiple myeloma cells.
other	34689723	hsa-mir-152	Nephrotic Syndrome	But miRNA- 152-3p has inadequate prognostic indicator for ESRD progression.
other	34689723	hsa-mir-152	Diabetes Mellitus, Type 2	But miRNA- 152-3p has inadequate prognostic indicator for ESRD progression.
exosome	34689576	hsa-mir-1275	Prostatic Neoplasms	Our findings indicate that PCa-derived exosomal miR-1275 promotes the proliferation and activity of osteoblasts via modulation of SIRT2/Runx2 signaling.
other	34689283	hsa-mir-130b	Coronary Artery Disease	Hsa-miR-18a-3p and hsa-miR-130b-5p might serve as biomarkers of CAD development and progression and warrant further attention.
transcription factor target	34689283	hsa-mir-18a	Coronary Artery Disease	Computational prediction of target genes indicated a relevant role of hsa-miR-130b-5p and hsa-miR-18a-3p in modulating the expression of genes associated with cardiovascular diseases.
other	34689169	hsa-mir-27a	Glioma	These results demonstrated that the lncRNA TMEM161B-AS1-hsa-miR-27a-3p-FANCD2/CD44 signal axis regulated the malignant biological behavior of GBM and TMZ resistance.
lncRNA target	34689155	hsa-mir-142	Osteosarcoma	To sum up, our study sheds light on the critical role of the oncogenic circ_0004674/miR5p/MCL1 axis in OS progression and chemoresistance, providing a novel potential target for OS therapy.
genetics_overexpression_suppress	34689058	hsa-mir-18a	Diabetic Retinopathy	Additionally, miR-18a-3p overexpression alleviated BRB injury to inhibit DR progression in vivo.
genetics_GWAS	34688806	hsa-mir-133b	Pain, Postoperative	Similarly, genetic overexpression of miR-133b-3p in the VPL reversed the allodynia established in CPSP rats via downregulation of P2X4R expression.
genetics_overexpression_promote	34688515	hsa-mir-425	Fibrosis, Atrial	5p could promote atrial remodeling, and overexpression of miR
genetics_overexpression_promote	34688515	hsa-mir-425	Atrial Fibrillation	5p could promote atrial remodeling, and overexpression of miR
other	34688465	hsa-mir-122	Inflammation	The reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the levels of microRNA-122 (miR-122) and genes related to inflammation, apoptosis, cell proliferation and liver function. RT-PCR results showed that the expression of miR-122 significantly decreased by GTW; the mRNA levels of inflammation-related genes il1beta, il6, tnfalpha, il10, cox2 and ptges significantly increased; the mRNA level of tgfbeta significantly decreased; the mRNA levels of apoptosis-related genes, caspase-8 and caspase-9, significantly increased; the mRNA level of bcl2 significantly decreased; the mRNA levels of cell proliferation-related genes, top2alpha and uhrf1, significantly reduced; the mRNA levels of liver function-related genes, alr and cyp3c1, significantly increased; and the mRNA level of cyp3a65 significantly decreased.
genetics_overexpression_promote	34688334	hsa-mir-375	Uterine Cervical Neoplasms	This study attempted to investigate the impact of overexpressed miR
lncRNA target	34688330	hsa-mir-155	Uterine Cervical Neoplasms	The composite NPs suppressed malignant characteristics of CC cells through down-regulation of miR-155 and activation of Tim-3 signal pathway on the surface of macrophages, promoting secretion of macrophage inflammatory factors.
other	34688135	hsa-mir-124	Neurogenic Inflammation	miR-124 is ubiquitously expressed in the nervous tissue and acts as a negative regulator of neuroinflammation.
genetics_knock down_suppress	34687491	hsa-mir-98	Acute Lung Injury	Our study demonstrated that NEAT1 knockdown alleviated LPS-induced ALI by targeting the miR
transcription factor target	34687270	hsa-mir-485	Lung Neoplasms	The present study discovered that CDK16, whose expression is under the regulation of APA and miR5p, is a potential target for prosenescence therapy for lung cancer.
epigenetics	34687205	hsa-mir-200c	Prostatic Neoplasms	Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters.
epigenetics	34687205	hsa-mir-429	Prostatic Neoplasms	Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters.
epigenetics	34687205	hsa-mir-141	Prostatic Neoplasms	Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters.
lncRNA target	34687205	hsa-mir-1260a	Prostatic Neoplasms	Finally, we show that miR-1260a also targets DNMT3A, although it does not seem to be involved in EMT in PCa.
genetics_overexpression_suppress	34687203	hsa-mir-99a	Thyroid Cancer, Papillary	Moreover, GRP94 overexpression reverses the inhibitory effect of miR-99a-3p on PTC metastasis.
transcription factor target	34687158	hsa-mir-34a	Obesity	sabdariffa has the potential to reduce FGF21 resistance in DIO rats through the suppression of miR-34a expression and an increase in the number of FGFR1 and beta-klotho receptors in adipose tissue.
genetics_GWAS	34687039	hsa-mir-221	Glioma	Furthermore, the miR-221/222 cluster acts as an epigenetic brake during glioma differentiation.
genetics_GWAS	34687039	hsa-mir-222	Glioma	Furthermore, the miR-221/222 cluster acts as an epigenetic brake during glioma differentiation.
other	34687038	hsa-mir-21	Vitiligo	5p in L skin leads to significantly higher levels of PDCD4 and Maspin, delaying wound re-epithelialization by reducing the proliferation and migration of keratinocytes.
exosome	34686767	hsa-mir-137	Schizophrenia	"EPP can be stratified in two subgroups: (a) a patients' group with mitochondrial dysfunction ""Psy-D"", having high miR-137 and low COX6A2 levels in exosomes, and (b) a ""Psy-ND"" subgroup with no/low mitochondrial impairment, including patients having miR-137 and COX6A2 levels in the range of controls."
genetics_knock down_suppress	34686662	hsa-mir-370	Carcinoma, Hepatocellular	Furthermore, knockdown of circUBE2J2 in HCC could downregulate KLF7, the target of miR
circulation_biomarker_diagnosis_ns	34686514	hsa-mir-208	Heart Diseases, Congenital	CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD.
circulation_biomarker_diagnosis_ns	34686514	hsa-mir-1	Heart Diseases, Congenital	CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD.
circulation_biomarker_diagnosis_ns	34686514	hsa-mir-499	Heart Diseases, Congenital	CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD.
lncRNA target	34686506	hsa-mir-124	Colonic Neoplasms	CONCLUSION: The expression of miR-124 inhibited cell proliferation, suppressed tumor cell migration and invasion, and enhanced apoptosis by its regulation of the expression of TET1, TET2, vimentin, and MMP-2 in colon cancer HT29 cells.
other	34686505	hsa-let-7a	Lung Neoplasms	CONCLUSION: This prospective study demonstrated that let-7a was correlated with tumor proliferation in lung cancer, with high prognostic value. Furthermore, it showed that repopulation, as correlated with let-7a, may exist during chemotherapy, which would give us a new perspective in overcoming the chemoresistance of lung cancer and would help in determining individual treatment strategies.
lncRNA target	34686504	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	The miR 145-5p-NRAS/MEST axis in NSCLC provides insights for the development of a NRAS/MEST targeting therapeutic approach to overcome gefitinib resistance in NSCLC patients.
exosome	34686196	hsa-mir-486	Stomach Neoplasms	5p via exosomes might be responsible for the peritoneal metastasis of gastric cancer cells by promoting epithelial-mesenchymal transition progress.
genetics_overexpression_promote	34686190	hsa-mir-425	Ovarian Neoplasms	5p overexpression in OC is negatively regulated by MAGI2-AS3.
other	34686186	hsa-mir-145	Stomach Neoplasms	RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients.
other	34686186	hsa-mir-23b	Stomach Neoplasms	RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients.
other	34686186	hsa-mir-143	Stomach Neoplasms	RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients.
other	34686186	hsa-mir-100	Stomach Neoplasms	RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients.
other	34686186	hsa-mir-409	Stomach Neoplasms	RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients.
other	34685705	hsa-mir-25	Obesity	3p may be a critical mediator between obesity and muscle wasting.
other	34685705	hsa-mir-25	Muscular Atrophy	3p may be a critical mediator between obesity and muscle wasting.
other	34685557	hsa-mir-185	Arrhythmogenic Right Ventricular Dysplasia	We found miR5p significantly upregulated in ARVC patients.
genetics_overexpression_promote	34685526	hsa-mir-21	psoriasis 1	3p overexpression in KCs.
lncRNA target	34685504	hsa-mir-491	Triple Negative Breast Neoplasms	5p and RABIF are potential prognostic biomarkers and targeting the novel FOCAD/miR
circulation_biomarker_prognosis_ns	34683154	hsa-mir-625	Mesothelioma, Malignant	Serum EV-enriched miR
exosome	34683087	hsa-mir-375	Alzheimer Disease	Four common MTI were observed between EV-miRNAs and AD-associated miRNAs: hsa-miR
exosome	34683087	hsa-mir-107	Alzheimer Disease	Four common MTI were observed between EV-miRNAs and AD-associated miRNAs: hsa-miR
other	34681793	hsa-mir-205	Breast Neoplasms	3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues.
other	34681793	hsa-mir-21	Breast Neoplasms	3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues.
other	34681793	hsa-mir-106b	Breast Neoplasms	3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues.
transcription factor target	34681754	hsa-mir-21	Osteoarthritis	Our study demonstrated the role of NFB/miR-21 axis in OA progression, and SC75741's therapeutic potential as a small-molecule inhibitor of miR-21/NFB-driven OA progression.
lncRNA target	34681754	hsa-mir-21	Cartilage Diseases	Novel NFB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling.
lncRNA target	34681723	hsa-mir-124	Polycystic Kidney Diseases	The transcriptional factor of C/EBP-alpha-PU.1 signaling, suppressed by miR-124 both in vivo (PKD retina) and in vitro (microglial cells), could serve as a key regulator in microglial activation and polarization.
transcription factor target	34681681	hsa-mir-143	cervical squamous cell carcinoma	Moreover, the miR3p sensitized the response of 7-HPV-related cervical SCC to chemotherapy by targeting BIRC2.
genetics_knock down_suppress	34681655	hsa-mir-542	Osteoporosis	Our findings suggest that MTX treatment-induced bone loss and marrow adiposity could be molecularly linked to miR
other	34681596	hsa-mir-17	Familial primary gastric lymphoma	92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients.
other	34681596	hsa-mir-17	hereditary diffuse gastric cancer	92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients.
other	34681596	hsa-mir-17	Epstein-Barr Virus Infections	92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients.
other	34681596	hsa-mir-17	Encephalocraniocutaneous lipomatosis	92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients.
other	34680592	hsa-mir-548a	Prostatic Neoplasms	Among the 800 profiled microRNA, eleven were identified as correlating with PCa, among which miR-548a-3p, miR5p and miR-520d-3p were confirmed using the RT-qPCR approach on an additional cohort of ten subjects.
other	34680592	hsa-mir-138	Prostatic Neoplasms	Among the 800 profiled microRNA, eleven were identified as correlating with PCa, among which miR-548a-3p, miR5p and miR-520d-3p were confirmed using the RT-qPCR approach on an additional cohort of ten subjects.
lncRNA target	34680556	hsa-mir-29b	Colorectal Neoplasms	In addition, we found that knocking down CRNDE could reduce lipid accumulation through the miR-29b-3p/ANGPTL4 axis and consequently induce autophagy of CRC cells.
circulation_biomarker_diagnosis_ns	34680545	hsa-mir-21	Depressive Disorder, Major	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155.
circulation_biomarker_diagnosis_ns	34680545	hsa-let-7e	Depressive Disorder, Major	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155.
circulation_biomarker_diagnosis_ns	34680545	hsa-mir-145	Depressive Disorder, Major	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155.
circulation_biomarker_diagnosis_ns	34680545	hsa-mir-223	Depressive Disorder, Major	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155.
circulation_biomarker_diagnosis_ns	34680545	hsa-mir-155	Depressive Disorder, Major	In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155.
transcription factor target	34680492	hsa-mir-148a	Rectal Neoplasms	miRNA-148a may be a biomarker of pCR following NACRT and can promote apoptosis and inhibit proliferation in CRC cells by directly targeting c-Met in vitro and enhancing tumor response to irradiation in vivo.
other	34680465	hsa-mir-451	Lung Neoplasms	In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls.
other	34680465	hsa-mir-451	Pulmonary Disease, Chronic Obstructive	In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls.
other	34680465	hsa-let-7c	Lung Neoplasms	In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls.
other	34680465	hsa-let-7c	Pulmonary Disease, Chronic Obstructive	In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls.
target gene	34680447	hsa-mir-196a	Chondrosarcoma	WISP-3 Stimulates VEGF-C-Dependent Lymphangiogenesis in Human Chondrosarcoma Cells by Inhibiting miR-196a-3p Synthesis.
exosome	34680382	hsa-mir-1915	Prostatic Neoplasms	Among nine top-ranked sEV-associated miRs, miR-6068 and miR3p were enriched in sEVs collected from PCa patients compared to healthy volunteers.
other	34680382	hsa-mir-6716	Prostatic Neoplasms	3p segregated AA from CA men and low from high Gleason score (GS), respectively.
exosome	34680382	hsa-mir-6068	Prostatic Neoplasms	Among nine top-ranked sEV-associated miRs, miR-6068 and miR3p were enriched in sEVs collected from PCa patients compared to healthy volunteers.
other	34680382	hsa-mir-3692	Prostatic Neoplasms	3p segregated AA from CA men and low from high Gleason score (GS), respectively.
circulation_biomarker_diagnosis_ns	34680375	hsa-mir-371a	Testicular Germ Cell Tumor	We aimed to test the feasibility of hypermethylated RASSF1A (RASSF1A(M)) detected in circulating cell-free DNA as a non-invasive diagnostic marker of testicular germ cell tumors, combined with miR-371a-3p.
genetics_GWAS	34680309	hsa-mir-424	Carcinoma, Renal Cell	Altogether, these findings suggest that epigenetic downregulation of miR
other	34678651	hsa-mir-21	Myocardial Infarction, Acute	Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a).
other	34678651	hsa-mir-499	Myocardial Infarction, Acute	Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a).
other	34678651	hsa-mir-133a	Myocardial Infarction, Acute	Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a).
exosome	34678513	hsa-mir-34c	Renal Interstitial Fibrosis	Here, we reveal that mesenchymal stem cell (MSC)-derived exosomes reside specifically in the injured kidney and deliver microRNA (miR)-34c-5p to reduce cellular activation and RIF by inhibiting CF.
circulation_biomarker_diagnosis_up	34678242	hsa-mir-210	Cardiomyopathies	The present study was designed to explore whether high sodium chloride (NaCl)-based diet (HSD) caused cardiac fibrosis regardless of blood pressure in Sprague-Dawley (SD) rats, and to further determine the effects and the underlying mechanisms of microRNA (miR)
other	34678217	hsa-mir-16-1	Carcinoma, Hepatocellular	MicroRNA-15a/16-1 represents a potential immunotherapy against HCC.
other	34678217	hsa-mir-15a	Carcinoma, Hepatocellular	MicroRNA-15a/16-1 represents a potential immunotherapy against HCC.
genetics_GWAS	34677712	hsa-mir-372	Hepatitis B	In this study, Single nucleotide polymorphisms (SNPs) in miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) were believed to play a role in HBV infection risk. To the best of our knowledge, the present study was the first to investigate the relevance of miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) gene polymorphisms to the risk of HBV infection in the Egyptian population.
other	34677646	hsa-mir-629	Anemia, Sickle Cell	Our data suggest that low levels of miR510 and miR629 expression are associated with greater SCA disease severity.
other	34677646	hsa-mir-510	Anemia, Sickle Cell	Our data suggest that low levels of miR510 and miR629 expression are associated with greater SCA disease severity.
lncRNA target	34676879	hsa-mir-200c	Intervertebral Disc Degeneration	To construct the IDD cell model, the nucleus pulposus (NP) cells were treated with lipopolysaccharide (LPS) 24 h following transfection with miR200c3p mimic or inhibitor.
other	34676588	hsa-mir-599	Esophageal Squamous Cell Carcinoma	The PTPRG-AS1/miR-599/PDK1 axis was further verified to aggravate the progression of ESCC cells. CONCLUSION: PTPRG-AS1 sponged miR-599 to up-regulate PDK1 expression, thereby promoting the proliferation and migration as well as glycolysis and stemness properties of ESCC cells.
exosome	34676493	hsa-mir-27a	Osteoporosis	This study aimed to evaluate the possible mechanisms of action underlying miR-27a loaded by mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in OP.
circulation_biomarker_diagnosis_ns	34676065	hsa-mir-194	Diabetic Nephropathies	We investigated circulating miRNA-194 levels as a biomarker of DKD prevalence and incidence, and the relationship between miRNA-194 and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP). Conclusion Circulating miRNA-194 levels could be a novel biomarker for DKD.
other	34676010	hsa-mir-223	Neurodegenerative Diseases	Although the function of miR-223 in the inflammation-related JAK/STAT pathway is unknown, it is particularly expressed in human degenerative nucleus pulposus cells.
circRNA target	34675978	hsa-mir-767	Carcinoma, Hepatocellular	In summary, this study revealed that circSLC30A7 is an essential tumor suppressor that inhibits HCC tumorigenesis through the miR5p/FBXW7/NOTCH1 axis.
target gene	34675977	hsa-mir-141	Liver Neoplasms	miR-141 can target the STAT4 gene expression to inhibit the proliferation, migration, and invasion of liver cancer cells.
transcription factor target	34675825	hsa-mir-181b	Autism Spectrum Disorder	Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD.
transcription factor target	34675825	hsa-mir-19b	Autism Spectrum Disorder	Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD.
transcription factor target	34675825	hsa-mir-20a	Autism Spectrum Disorder	Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD.
lncRNA target	34675680	hsa-mir-542	Carcinoma, Hepatocellular	The mechanism, circ-0003006, probably acted as a sponge of miR5423p and regulated HIF-1A levels in hepatocellular carcinoma cells. CONCLUSION: Circ-0003006 was demonstrated to promote HCC progression in vitro and in vivo by sponging miR5423p to release the inhibition on HIF-1A.
other	34675548	hsa-mir-125a	Colonic Neoplasms	RPARP-AS1/miR125a-5p Axis Promotes Cell Proliferation, Migration and Invasion in Colon Cancer.
transcription factor target	34675545	hsa-mir-489	Squamous Cell Carcinoma of Head and Neck	We have identified a novel bypass mechanism through which ET-1/ETAR are involved in TWIST signaling and downregulate miR3p expression, enabling OSCC cells to acquire the EMT phenotype.
circulation_biomarker_diagnosis_up	34675500	hsa-mir-196	Pulmonary Disease, Chronic Obstructive	5p in plasma of COPD patients and healthy volunteers were detected by qRT-PCR.
circulation_biomarker_diagnosis_up	34675500	hsa-mir-361	Pulmonary Disease, Chronic Obstructive	5p in plasma of COPD patients and healthy volunteers were detected by qRT-PCR.
genetics_overexpression_suppress	34674723	hsa-mir-204	Neurotic Disorders	In contrast, overexpression of miR
other	34674723	hsa-mir-204	Nerve Degeneration	In addition, down-regulation of miR5p induced neuronal deterioration in DG regions and depressive-like behaviors in rats.
other	34674715	hsa-mir-495	Depression	3p, and six differentially expressed mRNAs, Calml4, Ntrk2, VGAT, Gad1, Nr1d1, and Bdnf overlapped in the in vivo/vitro depression model.
other	34674715	hsa-mir-144	Depression	3p, and six differentially expressed mRNAs, Calml4, Ntrk2, VGAT, Gad1, Nr1d1, and Bdnf overlapped in the in vivo/vitro depression model.
lncRNA target	34674104	hsa-mir-490	Periodontal Diseases	Thus, the LINC00707/miR3p/FOXO1 axis modulated PDLSC osteogenic differentiation and might be a promising therapeutic target for periodontal diseases.
other	34673407	hsa-mir-155	Chemical and Drug Induced Liver Injury	In this study, we investigated the mechanisms by which microRNA-155 (miR-155) regulate cadmium-induced hepatotoxicity in rat hepatocytes (BRL 3A cells) and in vivo.
transcription factor target	34673296	hsa-mir-660	Carcinoma, Hepatocellular	5p-loaded M2-Exo augment HCC development through down-regulating KLF3.
transcription factor target	34672981	hsa-mir-218	Motor Disorders	Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.
exosome	34672863	hsa-mir-511	Rhinitis, Allergic	In conclusion, our data revealed that exosomal NEAT1 contributed to the pathogenesis of AR through the miR-511/NR4A2 axis.
other	34672722	hsa-mir-149	Hypoxia-Ischemia, Brain	It could be concluded that H19 competitively bound to miR5p to upregulate LIF expression and activate the PI3K/Akt pathway, thus reducing cardiomyocyte apoptosis in neonatal rats with HIBD.
other	34672248	hsa-mir-15a	Osteoporosis	This study provides a modality for the future use of miR-15a-5p in the treatment and prevention of osteoporosis.
exosome	34672203	hsa-mir-78	Ovarian Neoplasms	Expression of concern: DDP-resistant ovarian cancer cells-derived exosomal microRNA-30a-5p reduces the resistance of ovarian cancer cells to DDP.
genetics_knock down_promote	34671931	hsa-mir-4319	Colorectal Neoplasms	Additionally, HOXA-AS3 knockdown was determined to facilitate miR-4319 expression and reduce expression level of sphingolipid transporter 2 (SPNS2) in CRC cell lines.
other	34671433	hsa-mir-2467	Triple Negative Breast Neoplasms	3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652.
other	34671433	hsa-mir-4448	Triple Negative Breast Neoplasms	3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652.
other	34671433	hsa-mir-2392	Triple Negative Breast Neoplasms	3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652.
lncRNA target	34671432	hsa-mir-193a	Adenocarcinoma of Lung	Taken together, the results of the present study suggest that SNHG17 expression is upregulated in LUAD tissues and cells, and SNHG17 exerts tumor promoting effect by targeting the miR-193a-5p/NETO2 axis.
target gene	34671430	hsa-mir-125b	Breast Neoplasms	MicroRNA-100 inhibits breast cancer cell proliferation, invasion and migration by targeting FOXA1.
target gene	34671426	hsa-mir-23b	Colorectal Neoplasms	MicroRNA-23b-3p targets non-SMC condensing I complex subunit G to promote proliferation and inhibit apoptosis of colorectal cancer cells via regulation of the PI3K/AKT signaling pathway.
exosome	34671216	hsa-mir-150	Fibrosis, Renal	Thus, our results suggest that the blockade of exosomal miR
other	34671212	hsa-mir-126	Drug-Induced Kidney Injury	In both in vitro and in murine models of DDP-induced nephrotoxicity, lnc-MEG3 exacerbated DDPIN by negatively regulating miRNA-126 subsequently causing a decreased AKT/TSC/mTOR-mediated autophagy.
exosome	34671193	hsa-mir-656	Esophageal Squamous Cell Carcinoma	Subsequently, by comparing tumor cell development in vitro and in vivo, we found that the proliferation, migration and invasion capabilities of ESCC cells were significantly improved when miR-3656 was present. Additionally, the downregulation of ACAP2 triggered by exosomal-derived miR-3656 further promotes the activation of the PI3K/AKT and beta-catenin signaling pathways and ultimately improves the growth of ESCC cells both in vitro and in xenograft models.
lncRNA target	34670670	hsa-mir-548at	Asthma	5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected.
lncRNA target	34670670	hsa-mir-193a	Asthma	5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected.
lncRNA target	34670670	hsa-mir-625	Asthma	5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected.
lncRNA target	34670670	hsa-mir-22	Asthma	5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected.
lncRNA target	34670670	hsa-mir-206	Asthma	5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected.
lncRNA target	34670664	hsa-mir-148b	Leukemia, Myeloid, Acute	The targeted binding of miR-148b-3p to ATG14 was measured by dual-luciferase reporter gene assay, and the effect of miR-148b-3p/ATG14 axis on the phenotype of AML cells was observed in the rescue experiments.
circRNA target	34670484	hsa-mir-1231	Lichen Planus, Oral	The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB.
circRNA target	34670484	hsa-mir-146a	Lichen Planus, Oral	The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB.
circRNA target	34670484	hsa-mir-1	Lichen Planus, Oral	The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB.
circRNA target	34670484	hsa-mir-647	Lichen Planus, Oral	The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB.
transcription factor target	34670480	hsa-mir-4537	Stomach Neoplasms	In conclusion, in GC cells, miR-4537 inhibited the ability of cell proliferation, but on the contrary, it promoted the ability of cell apoptosis and improved radiosensitivity of the cells.
other	34670429	hsa-mir-22	Neurotoxicity Syndromes	CONCLUSION: LXA(4) ME can protect PC12 cells from ketamine-induced neurotoxicity by activating the miR-22/BAG5 signaling pathway.
lncRNA target	34669172	hsa-mir-145	Osteoarthritis	5p was up-regulated, and the expression of TGF-beta, Samd4, and p-stat3/stat3 was inhibited.
lncRNA target	34669152	hsa-mir-4691	COVID-19	5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas.
lncRNA target	34669152	hsa-mir-3925	COVID-19	5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas.
lncRNA target	34669152	hsa-mir-5196	COVID-19	5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas.
lncRNA target	34669152	hsa-mir-298	COVID-19	5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas.
transcription factor target	34668631	hsa-mir-99a	Lupus Erythematosus, Systemic	The upregulation of miR-99a-3p expression protected B cells from EIF4EBP1-mediated autophagy, whilst the downregulation of miR-99a-3p expression induced autophagy via the EIF4EBP1-mediated regulation of the autophagy signalling pathway in B cells isolated from individuals with SLE.
other	34668628	hsa-mir-1228	Breast Neoplasms	positive BC.
genetics_overexpression_promote	34668437	hsa-mir-223	Pulmonary Disease, Chronic Obstructive	Finally, in vitro overexpression of miR
genetics_overexpression_promote	34668437	hsa-mir-223	Pneumonia	Finally, in vitro overexpression of miR
other	34668391	hsa-mir-24	Alzheimer Disease	3p has a certain value in the diagnosis of AD and may be a potential biomarker.
other	34668337	hsa-mir-155	Breast Neoplasms	miRNA (miR)-155 is a potential biomarker for breast cancers.
genetics_overexpression_promote	34668273	hsa-mir-129	Intervertebral Disc Degeneration	5p was underexpressed, and EZH2 and MAPK1 levels were overexpressed in lumbar nucleus pulposus from human IVDD patients and in LPS-induced NP cells.
lncRNA target	34668101	hsa-mir-377	Lung Neoplasms	CONCLUSIONS: All these data reveal that miRNA-377 functions as a tumor suppressor in NSCLC and may serve as a potential therapeutic target for the treatment of NSCLC.
exosome	34667723	hsa-mir-29b	Diabetes Mellitus	Exosomal miRNA sequencing revealed that miR-29b was significantly downregulated in DMC group compared with ARC.
exosome	34667723	hsa-mir-29b	Cataract	Exosomal miRNA sequencing revealed that miR-29b was significantly downregulated in DMC group compared with ARC.
other	34667438	hsa-mir-224	Colorectal Neoplasms	The main objective of this study was to determine the role of microRNA-224 (miR-224) as well as microRNA-200a (miR-200a) in CRC.
other	34667438	hsa-mir-200a	Colorectal Neoplasms	The main objective of this study was to determine the role of microRNA-224 (miR-224) as well as microRNA-200a (miR-200a) in CRC.
epigenetics	34667160	hsa-mir-135a	Colorectal Neoplasms	More importantly, we found that miR-135a-5p expression is reversely upregulated by ERp29 through suppressing IL-1beta-elicited methylation of miR-135a-5p promoter region, a process for enterocyte to maintain a balance between miR-135a-5p and ERp29 but dysregulated in CRC.
other	34667156	hsa-mir-4523	Necrosis	Significantly, miR-4523 is downregulated in human necrotic femoral head tissues of DEX-taking patients.
genetics_knock down_suppress	34666672	hsa-mir-124	Inflammation	Knockdown of MAPKAPK5-AS1 reduced LPS-induced cell apoptosis and inflammation response, while overexpression of miR
lncRNA target	34666613	hsa-mir-522	Carcinoma, Hepatocellular	3p/SOCS5 axis as a novel target for HCC therapeutic strategy with potentiality.
lncRNA target	34666602	hsa-mir-20a	Esophageal Squamous Cell Carcinoma	Overall, METTL3 promoted m6A modification and the binding of DGCR8 to miR-20a-5p to further elevate the miR-20a-5p expression and inhibit NFIC transcription, thus promoting EMT, invasion and migration.
other	34666057	hsa-mir-503	Pulmonary Fibrosis	Our data indicated that PRSS8, hsa-miR-614, and hsa-miR5p might be involved in the migration and invasion of IPF related cells.
other	34666057	hsa-mir-614	Pulmonary Fibrosis	Our data indicated that PRSS8, hsa-miR-614, and hsa-miR5p might be involved in the migration and invasion of IPF related cells.
genetics_GWAS	34665919	hsa-mir-376	Glioma	Herein, we describe the epigenetic silencing of the uc.160+ T-UCR in gliomas and mechanistically define a novel RNA-RNA regulatory network in which uc.160+ modulates the biogenesis of several members of the miR-376 cluster.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-183	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-150	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-141	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-342	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-224	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
circulation_biomarker_diagnosis_up	34665700	hsa-mir-122	Behcet Syndrome	5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS.
genetics_overexpression_promote	34665305	hsa-mir-34a	Carcinoma, Hepatocellular	In HCC cells, TLR8-AS1 overexpression downregulated mature miR-34a, but not miR-34a precursor.
genetics_knock down_promote	34664835	hsa-mir-125a	Cholesteatoma	Also, circ_0074491 knockdown activated the PI3K/Akt pathway in cholesteatoma keratinocytes via miR
lncRNA target	34664776	hsa-mir-625	Carcinoma, Non-Small-Cell Lung	Notably, circ-SNAP47 interference suppressed xenograft tumor growth of DDP-tolerant NSCLC cells by elevating miR
genetics_overexpression_promote	34664737	hsa-mir-125b	Carcinoma, Hepatocellular	In addition, the inhibition of miR-125b and HK2 overexpression partly reversed the inhibitory effect of hsa_circ_0001806 silencing on HCC cell proliferation, migration and glycolysis. CONCLUSION: The inhibition of hsa_circ_0001806 suppressed HCC cell proliferation, migration and glycolysis through mediating miR-125b/HK2 axis.
other	34664684	hsa-mir-17	Coronary Disease	The results suggested that hsa_circ_105039 exerted a protective effect by promoting miR17/cyclinD2 in DMSOinduced iPS cardiomyocytes, which indicated that hsa_circ_105039 is a potential key molecule for the diagnosis of CHD.
other	34664683	hsa-mir-491	Pulmonary Disease, Chronic Obstructive	Reverse transcriptionquantitative PCR was carried out to evaluate the expression of miR491 and MMP9 mRNA in the different groups of patients with COPD. Although there was no difference in the expression of miR491 in patients carrying different genotypes of rs1056629, the expression levels of TNFalpha, IL6 and MMP9 were increased in patients with COPD carrying the CC and AC genotypes of rs1056629.
genetics_overexpression_promote	34664678	hsa-mir-497	Glioma	In addition, forced overexpression of miR497 or MIR497HG significantly inhibited the proliferation and cell cycle progression of glioma cell lines.
lncRNA target	34664412	hsa-mir-494	Reperfusion Injury, Hepatic Ischemia	Functional rescue experiments were performed to confirm the effects of miR-494 and JUND on hepatic I/R injury. Overall, Dex repressed NLRP3 inflammasome and alleviated hepatic I/R injury via the miR-494/JUND/PI3K/AKT/Nrf2 axis.
other	34663892	hsa-mir-582	Obesity	These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny.
other	34663892	hsa-mir-582	Metabolic Diseases	These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny.
lncRNA target	34663837	hsa-mir-186	Squamous Cell Carcinoma of Head and Neck	MiR-186 was reported to serve as a tumor suppressor in OSCC, and the down-regulation of miR-186 was reported to lead to higher expression of oncogenic factor SHP2 and the activation of growth promoting signaling.
other	34663837	hsa-mir-296	Squamous Cell Carcinoma of Head and Neck	5p was specifically up-regulated in saliva of OSCC patients.
other	34663368	hsa-mir-4303	Osteoarthritis	In this paper, we aim to investigate the underlying mechanisms by which miR-4303 regulates osteoarthritis.
exosome	34663350	hsa-mir-769	Osteosarcoma	CONCLUSIONS: In summary, this study demonstrates for the first time that BMSC-derived exosomal miR
lncRNA target	34663343	hsa-mir-1285	Adenocarcinoma of Lung	CONCLUSIONS: These results suggest that LINC00337 acts as an oncogenic lncRNA, targeting miR3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma.
target gene	34663310	hsa-mir-152	Breast Neoplasms	TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination.
transcription factor target	34663177	hsa-mir-744	Cardiomyopathies	CONCLUSION: Our findings provide new insights that ISO pretreatment can remarkedly regulate miR-744 and its downstream target SIRT6 to mitigate myocardial injury induced by H/R.
lncRNA target	34663169	hsa-mir-23b	Spinal Cord Injuries	After EV treatment, the motor function of SCI rats was improved, SCI was relieved, and miR-23b expression was increased. To conclude, The miR-23b delivered by BMSC-EVs targets TLR4 and inhibits the activation of NF-kappaB pathway, relieves the inflammatory response, so as to improve SCI in rats.
other	34661851	hsa-mir-7a	Ischemia	MicroRNA-7a-5p (miR-7a-5p) is closely related to apoptosis and plays an important role in ischemia/reperfusion (I/R) injury.
other	34661851	hsa-mir-7a	Myocardial Reperfusion Injury	MiR-7a-5p/VDAC1 axis might be utilized as hopeful biomarkers to reveal the potential mechanism of myocardial I/R injury.
lncRNA target	34661812	hsa-mir-134	Ischemic Stroke	Ectopic SNHG7 expression protected against OGD-induced neuronal cell injury by inducing FGF9 through sponging miR5p, providing a novel therapeutic target for ischemic stroke.
lncRNA target	34661812	hsa-mir-134	Osteochondritis Dissecans	Ectopic SNHG7 expression protected against OGD-induced neuronal cell injury by inducing FGF9 through sponging miR
circulation_biomarker_diagnosis_ns	34661810	hsa-mir-1260a	Breast Neoplasms	miR-4521 and miR-1260a showed no change in plasma of breast cancer patients (n = 19).
other	34661810	hsa-mir-93	Breast Neoplasms	5p.
other	34661810	hsa-mir-16	Breast Neoplasms	5p.
circulation_biomarker_diagnosis_ns	34661810	hsa-mir-4521	Breast Neoplasms	miR-4521 and miR-1260a showed no change in plasma of breast cancer patients (n = 19).
other	34661762	hsa-mir-34	Non-alcoholic Fatty Liver Disease	The AUCs (CI) of candidate NAFLD markers were in the order of miRNA-34 0.72 (0.66-0.77) < ALT 0.73 (0.67-0.79) < BMI 0.81 (0.76-0.86) < cholesterol < 0.85 (0.79-0.90) < CRP 0.88 (0.84-0.92).
other	34661743	hsa-mir-129	Brain Ischemia	Transient cerebral ischemia induces differential expression of miR-129 and miR-384-5p which influences apoptosis by regulating apoptotic factors caspase-3 and bcl-2
other	34661743	hsa-mir-384	Brain Ischemia	Transient cerebral ischemia induces differential expression of miR-129 and miR-384-5p which influences apoptosis by regulating apoptotic factors caspase-3 and bcl-2
other	34661273	hsa-mir-370	Colorectal Neoplasms	5p/EZH1 axis.
circulation_biomarker_diagnosis_ns	34661272	hsa-mir-200b	Lung Neoplasms	CONCLUSIONS: Low-dose spiral CT combined with plasma miR-200b and miR-200c for lung cancer screening in the physical examination population can help to detect lung cancer patients with early symptoms that are not significant, and achieve early diagnosis and early treatment.
circulation_biomarker_diagnosis_ns	34661272	hsa-mir-200c	Lung Neoplasms	CONCLUSIONS: Low-dose spiral CT combined with plasma miR-200b and miR-200c for lung cancer screening in the physical examination population can help to detect lung cancer patients with early symptoms that are not significant, and achieve early diagnosis and early treatment.
lncRNA target	34660700	hsa-mir-138	Hemangioma, Infantile	Taken together, we demonstrate that LncRNA-MCM3AP-AS1 promotes the progression of infantile hemangiomas by increasing the glycolysis via regulating miR5p/HIF-1alpha axis.
other	34660700	hsa-mir-106b	Hemangioma, Infantile	Furthermore, we demonstrated that MCM3AP-AS1 bound to miR-106b-3p which promotes glycolysis in IH.
circulation_biomarker_diagnosis_ns	34660637	hsa-mir-19b-1	Urothelial   Carcinoma	In plasma samples, miR
circulation_biomarker_diagnosis_ns	34660637	hsa-mir-378	Urothelial   Carcinoma	In plasma samples, miR
other	34660637	hsa-mir-19a	Urothelial   Carcinoma	The Kaplan-Meier curve showed that lower expression of miR-19a, miR-19b, miR-636 and miR-378, and higher expression of miR5p were associated with poor prognosis in patients with bladder cancer.
circulation_biomarker_diagnosis_ns	34660637	hsa-mir-155	Urothelial   Carcinoma	In plasma samples, miR
circulation_biomarker_diagnosis_ns	34660637	hsa-mir-636	Urothelial   Carcinoma	In plasma samples, miR
other	34660637	hsa-mir-708	Urothelial   Carcinoma	The Kaplan-Meier curve showed that lower expression of miR-19a, miR-19b, miR-636 and miR-378, and higher expression of miR5p were associated with poor prognosis in patients with bladder cancer.
circulation_biomarker_diagnosis_ns	34660637	hsa-mir-19b	Urothelial   Carcinoma	In plasma samples, miR
other	34660566	hsa-mir-129	Pancreatic Neoplasms	Pancreatic Cancer Progression Is Regulated by IPO7/p53/LncRNA MALAT1/MiR-129-5p Positive Feedback Loop.
target gene	34660323	hsa-mir-375	Stomach Neoplasms	Long Non-Coding RNA GRIK1-AS1 Inhibits the Proliferation and Invasion of Gastric Cancer Cells by Regulating the miR-375/IFIT2 Axis.
genetics_overexpression_promote	34660270	hsa-mir-148a	Carcinoma, Hepatocellular	MiR-148a-3p overexpression effectively inhibited HCC cell proliferation and metastasis stimulated by MTF-1, with increased apoptosis.
exosome	34660257	hsa-mir-532	Osteosarcoma	CircNRIP1 Encapsulated by Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Aggravates Osteosarcoma by Modulating the miR-532-3p/AKT3/PI3K/AKT Axis.
other	34659890	hsa-mir-27a	Carcinoma, Non-Small-Cell Lung	Downregulation of HOXC6 by miR-27a ameliorates gefitinib resistance in non-small cell lung cancer.
transcription factor target	34659819	hsa-mir-488	Esophageal Squamous Cell Carcinoma	5p targets associated with ESCC.
circulation_biomarker_diagnosis_up	34659807	hsa-mir-10a	Pneumonia, Mycoplasma	Among paediatric MPP patients, miR-10a-3p expression had a positive correlation with the white blood cells count, erythrocyte sedimentation rate (ESR), and CRP expression, while COX11 mRNA expression had a positive correlation with ESR and CRP.
genetics_GWAS	34659590	hsa-mir-149	Autoimmune Diseases	In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.
genetics_GWAS	34659590	hsa-mir-27a	Autoimmune Diseases	In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.
other	34659578	hsa-mir-29a	Carcinoma, Hepatocellular	TUG1 promotes the expression of IFITM3 in hepatocellular carcinoma by competitively binding to miR-29a.
target gene	34659572	hsa-mir-206	Ovarian Neoplasms	Keratin 80 regulated by miR-206/ETS1 promotes tumor progression via the MEK/ERK pathway in ovarian cancer.
genetics_overexpression_promote	34659565	hsa-mir-338	Stomach Neoplasms	5p was significantly lower-expression in cisplin-resistant GC cells SGC7901/DDP, and cell viability assay and flow cytometry confirmed that overexpression of miR
other	34659561	hsa-mir-182	Breast Neoplasms	miR-182 is upregulated in breast, lung and liver cancers and has good potential for cancer diagnosis.
other	34659561	hsa-mir-182	Carcinoma, Hepatocellular	miR-182 is upregulated in breast, lung and liver cancers and has good potential for cancer diagnosis.
transcription factor target	34659560	hsa-mir-25	Urinary Bladder Neoplasms	BC cell lines T24 and 5637 were used to transfect miR-25 mimics or inhibitors.
genetics_knock down_promote	34659556	hsa-mir-143	Stomach Neoplasms	The knockdown of hsa_circRNA_101996 dramatically suppressed the cell migration, invasion, and proliferation of GC cells by sponging to absorb miR-143 and elevated the expression of TET2.
target gene	34659550	hsa-mir-4507	Carcinoma, Non-Small-Cell Lung	MIR-4507 Targets TP53 to Facilitate the Malignant Progression of Non-small-cell Lung Cancer.
genetics_knock down_suppress	34659544	hsa-mir-527	Carcinoma, Hepatocellular	Knockdown of hsa_circ_0001306 could downregulate F-box and WD repeat domain containing 7(FBXW7), a target of miR-527, thereby promoting HCC cell proliferation and invasion. Hsa_circ_001306 is significantly downregulated in HCC, and the hsa_circ_0001306/miR-527/FBXW7 axis plays an important role in HCC progression.
lncRNA target	34659543	hsa-mir-28	Squamous Cell Carcinoma of Head and Neck	3p directly targeted the 3'UTR of H2A histone family, member X (H2AFX), which served as a tumor suppressor in migration and invasion of HNSCC.
genetics_knock down_promote	34659534	hsa-mir-29c	Pancreatic Carcinoma	HOXA-AS3 level was upregulated in PC, and its knockdown suppressed PC cells proliferation, whereas miR-29c antagonized the regulatory effect of HOXA-AS3 knockdown by directly binding to HOXA-AS3.Moreover, CDK6 was a target of miR-29c and miR-29c exerted anti-proliferation effects through inhibiting CDK6.
lncRNA target	34659523	hsa-mir-185	Pancreatic Carcinoma	Lastly, LINC00152 inhibition targeted miR
target gene	34659511	hsa-mir-361	Pancreatic Neoplasms	MicroRNA-361 reduces the viability and migratory ability of pancreatic cancer cells via mediation of the MAPK/JNK pathway.
lncRNA target	34659510	hsa-mir-1236	Glioblastoma	The results demonstrated that LGR6, a microRNA3p target candidate, promoted GBM cell viability and invasion, and mediated temozolomide sensitivity in SHG-44 and U251 GBM cells.
other	34659508	hsa-mir-145	Cardiomegaly	5p may indicate the severity of CHF, may serve as diagnostic and prognostic biomarkers and may be involved in CHF progression by regulating inflammatory responses.
lncRNA target	34659498	hsa-mir-218	Spinal Cord Injuries	Depletion of miR-218 protected PC12 cells against H(2)O(2)-induced cell injury via the upregulation of spred2, which provided a promising therapeutic strategy for spinal cord injury.
other	34659494	hsa-mir-142	Liver Neoplasms	lncRNA ST8SIA6-AS1 facilitates proliferation and invasion in liver cancer by regulating miR-142-3p.
other	34659430	hsa-mir-5007	Carcinoma, Hepatocellular	LncRNA-URHC Functions as ceRNA to Regulate DNAJB9 Expression by Competitively Binding to miR-5007-3p in Hepatocellular Carcinoma.
other	34659414	hsa-mir-495	Breast Neoplasms	The study concluded that the decreased expression of miR-495 observed in breast cancer patients showed a negative correlation with NRXN-1 while the increased expression of NRXN-1 and CNTN-1 was linked with disease advancement and distant metastases and could be the important predictive marker for breast cancer patients.
transcription factor target	34659411	hsa-mir-520b	Breast Neoplasms	CONCLUSIONS: miR-520b inhibited PTEN and aggravated breast tumors.
transcription factor target	34659401	hsa-mir-141	Polycystic Ovary Syndrome	3p might play a role in glucose and lipid metabolism in PCOS-obese patients by targeting PTEN.
genetics_overexpression_promote	34659347	hsa-mir-423	Hepatoblastoma	Furthermore, through conducting reversal experiments, we evidenced that the inhibiting effects of circSETD3 overexpression on HB development were abrogated by upregulating miR
other	34659329	hsa-mir-873	Stomach Neoplasms	CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis.
lncRNA target	34658906	hsa-mir-195	Cardiomyopathies	5p inhibits TGF-beta1-smads-snail pathway by targeting Smad7, thus inhibiting EndMT and alleviating myocardial fibrosis in DCM.
lncRNA target	34658906	hsa-mir-195	Diabetic Cardiomyopathies	5p inhibits TGF-beta1-smads-snail pathway by targeting Smad7, thus inhibiting EndMT and alleviating myocardial fibrosis in DCM.
circulation_biomarker_diagnosis_ns	34658571	hsa-mir-21	Esophageal Neoplasms	This study aimed to isolate MiR 21 from serum samples of carcinoma oesophagus patients and healthy subjects for determining its strength of association in various stages of the carcinoma oesophagus.
lncRNA target	34658308	hsa-mir-101	Burkitt Lymphoma	In conclusion, TCF3 combined with HDAC3 down-regulates the expression of miR-101, thereby promoting the proliferation of BL cells and inhibiting their apoptosis.
lncRNA target	34658294	hsa-mir-150	Pancreatic Carcinoma	Together, these findings indicate that a noval m6A-LIFR-AS1 axis promotes PC progression at least in part via regulation of the miR5p/VEGFA axis, indicating that this regulatory axis may be a viable clinical target for the treatment of PC.
genetics_knock down_promote	34658165	hsa-mir-646	Carcinoma, Non-Small-Cell Lung	MiR-646 bound to the AKT3 3' untranslated region in NSCLC cells, and miR-646 overexpression-induced effects in NSCLC cells were partly overturned by the addition of AKT3 overexpression plasmid.
genetics_overexpression_promote	34658120	hsa-mir-338	Stomach Neoplasms	3p in HAGLR-overexpressing HGC27 5-Fu R cells successfully overrode the HAGLR-promoted 5-Fu resistance through targeting LDHA.
transcription factor target	34657879	hsa-mir-129	gastric adenocarcinoma	Furthermore, key targets related to TLR3 were identified in STAD, mainly including MIR-129 (GCAAAAA), PLK1, and V$IRF1_01.
genetics_overexpression_suppress	34657624	hsa-mir-144	Stomach Neoplasms	3p overexpression inhibited proliferation, migration and invasion of gastric cancer cells.
lncRNA target	34657558	hsa-mir-340	Breast Neoplasms	All in all, LINC01094 promotes BC cell proliferation and cell cycle progression and inhibits apoptosis via modulating miR
genetics_overexpression_suppress	34657551	hsa-mir-130a	Colorectal Neoplasms	MiR-130a-3p overexpression contributed to a decrease in CRC cell proliferation.
other	34657331	hsa-mir-196b	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-449a	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-135a	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-146b	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-34c	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-6739	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-34b	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-765	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657331	hsa-mir-5000	Asthenozoospermia	3p and miR-196b-5p) were identified in asthenospermia for the first time in this study.
other	34657232	hsa-mir-29b	Glaucoma	Our study is the first experimental investigation to shed light on a novel molecular mechanism of the GAS5/miR-29b-3p/STAT3 axis in an H(2)O(2)-induced oxidative injury model using HTMCs, which may offer a promising therapeutic approach against glaucoma.
circRNA target	34657099	hsa-mir-548p	Carcinoma, Hepatocellular	Circ_0073181 and PTPRE were upregulated, and miR-548p was decreased in HCC tissues and cells. Circ_0073181 silencing could inhibit HCC cell growth and metastasis partly by regulating the miR-548p/ PTPRE axis, providing a promising therapeutic target for the HCC treatment.
lncRNA target	34656159	hsa-mir-1265	Colorectal Neoplasms	CONCLUSION: Our results identified that circSLC6A6/miR-1265/C2CD4A axis, which was involved in CRC via the p53 signaling pathway, may serve as a therapeutic target for CRC.
genetics_knock down_promote	34656128	hsa-mir-3065	Colorectal Neoplasms	3p was overexpressed in colorectal cancer and that its high expression was associated with poor prognosis of patients with colorectal cancer.
genetics_overexpression_suppress	34656115	hsa-mir-140	Stomach Neoplasms	Overexpression of SNHG12 or FAM83B reduced the inhibition of overexpression of miR
genetics_GWAS	34656082	hsa-mir-146a	Brucellosis	The aim of the present study was to investigate the association between risk of brucellosis and genetic variations in miR-146a. CONCLUSIONS: Consequently, our study demonstrated significant differences in genotype and haplotype frequencies of miR-146a variants between brucellosis patients and controls.
genetics_overexpression_promote	34656078	hsa-mir-23b	Leukemia, Myeloid, Acute	The expression of miR-23b-5p and TRIM14 was silenced or overexpressed to explore their biological functions in AML.
lncRNA target	34656066	hsa-mir-135b	Atrial Fibrillation	RESULTS: The expression of miR-135b was downregulated, and those of TGFBR1, TGFBR2, target genes of miR-135b were upregulated in human AF tissues and negatively regulated by miR-135b in RCFs. CONCLUSION: Quercetin may alleviate AF by inhibiting fibrosis of atrial tissues through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression.
lncRNA target	34655977	hsa-mir-148b	Keloid	These results find that HOXA11-AS promotes keloid progression by miR-148b-3p/IGFBP5 axis, suggesting the potential of targeting HOXA11-AS/miR-148b-3p/IGFBP5 axis to combat keloid.
lncRNA target	34655847	hsa-mir-18b	Diabetic Retinopathy	In addition, miR-18b was found to target mitogen-activated protein kinase kinase kinase 1 (MAP3K1), thereby inhibiting NF-kappaB p65 phosphorylation to alleviate DR. Overall, this study highlights the potential of hUCMSCs-sEVs as biomaterials for anti-inflammatory and anti-apoptotic effects in DR by transferring miR-18b.
lncRNA target	34655744	hsa-let-7d	Polycystic Ovary Syndrome	In conclusion, miR-let-7d-3p was a crucial miRNA up-regulated in GCs of PCOS, and inhibited cell proliferation by targeting TLR4 gene.
other	34655407	hsa-mir-522	Breast Neoplasms	3p to PBX1 3'-UTR and may be suggested as a novel prognostic biomarker for the diseases.
transcription factor target	34655390	hsa-mir-409	Stroke	Collectively, rTMS could protect against stroke-induced cognitive deficits, which depended on the inhibition of miR
genetics_overexpression_promote	34655362	hsa-mir-574	Stomach Neoplasms	3p was overexpressed in GC tissues and cells.
exosome	34655361	hsa-mir-192	Gallbladder Neoplasms	5p/MAD2L1 axis was identified, suggesting lncRNA STEAP3-AS1, might as a sponge of exosome-derived hsa-miR
other	34655330	hsa-mir-34a	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Then the synergic effects of miR-34a in combination with doxorubicin were investigated on cell death of acute T-cell lymphoblastic leukemia Jurkat cell line, as well as the expression of some genes including Caspase-3, Bcl-2, and p53 which are involved in apoptosis.
other	34655124	hsa-mir-96	Prostatic Neoplasms	5p mimic presented a cancer promoter role in prostate carcinoma cells.
circulation_biomarker_diagnosis_ns	34654834	hsa-mir-532	Lung Neoplasms	5p was quantifiable in plasma from the corresponding LUADs.
transcription factor target	34654817	hsa-mir-150	Brain Injuries	We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats.
transcription factor target	34654817	hsa-mir-328a	Bone Diseases	We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats.
transcription factor target	34654817	hsa-mir-150	Bone Diseases	We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats.
transcription factor target	34654817	hsa-mir-328a	Brain Injuries	We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats.
other	34654721	hsa-mir-19b	Glioblastoma	Finally, we find that by a Cx43-dependent mechanism, but likely not direct channel-mediated diffusion, miRNAs associated with cell-matrix adhesion are transferred from GBM to astrocytes and miR-19b promotes invasion, revealing a role for post-transcriptional manipulation of astrocytes in fostering an invasion-permissive peritumoral niche.
genetics_knock down_promote	34654473	hsa-mir-93	Diabetic Nephropathies	CONCLUSION: KCNQ1OT1 knockdown inhibited cell proliferation and fibrosis and induced apoptosis in DN by regulating miR
circulation_biomarker_prognosis_ns	34654440	hsa-mir-499a	Myocardial Dysfunction	RESULTS: Our results revealed a poor expression of miR-499a-5p in the serum of SIMD patients, while no significant difference was evident for miR-451 and miR-378.
circulation_biomarker_prognosis_ns	34654440	hsa-mir-499a	Sepsis	RESULTS: Our results revealed a poor expression of miR-499a-5p in the serum of SIMD patients, while no significant difference was evident for miR-451 and miR-378.
other	34654438	hsa-mir-132	Alzheimer Disease	glutamate and GABA oppositely regulated miR-132 levels in sEVs, resulting in the opposite destiny of recipient cells challenged with Aβ.
lncRNA target	34654357	hsa-mir-143	Abortion, Spontaneous	3p/S100A11 axis, providing novel biomarkers and diagnostic targets for RPL.
genetics_GWAS	34654353	hsa-mir-877	Prostatic Neoplasms	5p action on prostate cancer cells was investigated by luciferase activity assay with wide-type or mutation.
exosome	34653794	hsa-mir-142	Lung Neoplasms	CAFs-derived exosomes suppressed the role of PBMCs induced-killing of lung cancer cells and promoted lung cancer progression by OIP5-AS1/ miR
other	34653751	hsa-mir-449	Papilloma, Inverted	Notably, the miR-449 cluster was found to be significantly underexpressed in SNSCC, and the cluster markedly changed in SNIP during the malignant transition into SNSCC. CONCLUSIONS: Our findings suggest that miR-449 may be involved in the molecular pathogenesis of SNIP and its malignant transformation into SNSCC.
other	34653729	hsa-mir-93	Severe Acute Respiratory Syndrome	The results obtained demonstrate that the production of IL-8 protein is enhanced in bronchial epithelial IB3-1 cells by treatment with the SARS-CoV-2 Spike protein and that IL-8 synthesis and extracellular release can be strongly reduced using an agomiR molecule mimicking miR5p.
lncRNA target	34653678	hsa-mir-6512	Periodontitis	In conclusions, SNHG7 improves the osteogenic differentiation of hDPSCs by inhibiting miR3p expression under 50 ng/mL TNF-alpha-induced inflammatory environment, which provided potential targets for the treatment of periodontitis.
other	34652942	hsa-mir-1	Muscular Diseases	We uncovered a muscle cell vulnerability by studying miR-1, a deeply conserved, muscle-specific microRNA whose ablation causes various muscle defects.
genetics_knock down_promote	34652879	hsa-mir-708	Uterine Cervical Neoplasms	5p inhibitor attenuated the effects of LINC00514 knockdown on cell proliferation and invasion in CSCC cells.
other	34652691	hsa-mir-494	Neurotoxicity Syndromes	3p upregulation in primary cultured hippocampal neurons.
lncRNA target	34652636	hsa-mir-124	Neurogenic Inflammation	MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear.
transcription factor target	34652615	hsa-mir-34	Coronary Stenosis	This study is focused on the investigation of vitronectin, miR-193, miR-34, and miR-520 expression levels in PBMCs isolated from stenosed patients. CONCLUSIONS: The molecular events in the vessel stenosis may be affected by targeting vitronectin with miR-520 and miR-34.
transcription factor target	34652615	hsa-mir-520	Coronary Stenosis	This study is focused on the investigation of vitronectin, miR-193, miR-34, and miR-520 expression levels in PBMCs isolated from stenosed patients. CONCLUSIONS: The molecular events in the vessel stenosis may be affected by targeting vitronectin with miR-520 and miR-34.
other	34652536	hsa-mir-212	Non-alcoholic Fatty Liver Disease	5p was downregulated in NAFLD patients.
lncRNA target	34652260	hsa-mir-16	Carcinoma, Hepatocellular	5p countervailed the suppressive effect of SNHG22 deficiency on HCC cell proliferation, migration, invasion, and angiogenesis.
lncRNA target	34652259	hsa-mir-24	AIDS-Related Complex	Taken together, the enforced expression of circ_EPB41 ameliorated UV irradiation-induced apoptosis of lens epithelial cells by miR3p/BPNT1 pathway, providing us with a potential target for the therapy of UV-caused ARC.
lncRNA target	34652259	hsa-mir-24	UV-Sensitive Syndrome	3p/BPNT1 pathway, providing us with a potential target for the therapy of UV-caused ARC.
genetics_overexpression_promote	34652255	hsa-mir-492	Osteoarthritis	In conclusion, hsa_circ_0005567 overexpression promoted M2 macrophage polarization through miR-492/SOCS2 axis to reduced chondrocyte apoptosis, which could inhibit osteoarthritis progression.
target gene	34652079	hsa-mir-766	Triple Negative Breast Neoplasms	RMRP promotes the growth, migration, and invasion of TNBC cells via the miR-766-5p/YAP1 axis.
lncRNA target	34651663	hsa-mir-429	Lymphoma, Large B-Cell, Diffuse	Therefore, in DLBCL, the tumor suppressor effect of hsamiR429 may be achieved by targeted downregulation of CBX8, suggesting that hsamiR429 may be used as a diagnostic marker and a potential nucleic acid drug for DLBCL.
other	34651657	hsa-mir-181a	Liver Cirrhosis	Both MALAT1 and miR181a5p expression performed well in their ability to differentiate patients with liver fibrosis from healthy volunteers, and MALAT1 expression was associated with the severity of liver fibrosis. The MALAT1/miR181a5p axis was involved in regulating collagen production and inflammation by activating TLR4/NFkappaB signaling, which may be conducive to liver fibrosis treatment in the future.
lncRNA target	34651293	hsa-mir-30	Colorectal Neoplasms	CONCLUSION The microRNA-330 inhibited cell proliferation by suppressing thymidylate synthase (TYMS) in colorectal cancer.
lncRNA target	34651285	hsa-mir-21	Fatty Liver	This study examined whether astaxanthin (ASX) could alleviate hepatic steatosis in rats fed a high-fat diet (HFD) by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/miR-21 axis. In conclusion, ASX prevents hepatic steatosis mainly by transactivating Nrf2 and is associated with the suppression of miR-21 and Srebp1/2 and upregulation of Pparalpha expression.
lncRNA target	34650983	hsa-mir-146a	Carcinoma, Pancreatic Ductal	5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC.
lncRNA target	34650983	hsa-mir-877	Carcinoma, Pancreatic Ductal	5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC.
genetics_knock down_suppress	34650909	hsa-mir-149	Stomach Neoplasms	SLCO4A1-AS1 knockdown also determined the function of GC cells but was diminished by the miR-149 inhibitor in vitro.
genetics_overexpression_promote	34650771	hsa-mir-144	Carcinoma, Hepatocellular	CONCLUSION: Overexpression of GAS5 upregulates ATF2 through miR
circulation_biomarker_diagnosis_up	34650741	hsa-mir-374a	Venous Thrombosis	We detected the expression levels of miR-374a-5p in PBMCs and plasma D-dimer of the two groups of patients 1 d before surgery, and 1 d, 3 d, and 5 d after surgery, and analyzed the predictive value, and the correlation between miR-374a-5p and plasma D-dimer for DVT by ROC curve.
target gene	34650713	hsa-mir-145	Psoriasis	miR-145-5p inhibits psoriasis progression by regulating the Wnt/β-catenin pathway.
lncRNA target	34650695	hsa-mir-101	Breast Neoplasms	The miR3p levels were indirectly proportional to the MALAT1 expressions and the suppressed BC cells.
lncRNA target	34650693	hsa-mir-15a	Colonic Neoplasms	Finally, inhibiting miR-15a expression largely abolished the effect of SNHG12 silencing on colon cancer cells. In conclusion, our data uncovered the critical role of SNHG12 in the development and progression of colon cancer through regulating the miR-15a/PDK4 axis, therefore providing a promising target for treating this disease.
exosome	34650689	hsa-mir-1913	Osteosarcoma	The exosomal transfer of human bone marrow mesenchymal stem cell-derived miR-1913 inhibits osteosarcoma progression by targeting NRSN2.
other	34650687	hsa-mir-29a	obsolete Helicobacter pylori infectious disease	The miR-29a/MMP9 axis levels were increased in the HP positive patients but not in the HP negative patients.
lncRNA target	34650685	hsa-mir-181b	Inflammation	Here, up-regulation of miR-181b or down-regulation of HMGB1 exerted similar effects as baicalin and down-regulated miR-181b reversed the anti-inflammatory effect of baicalin in RAW264.7 inflammation models. CONCLUSION: Baicalin can inhibit LPS-induced inflammation in RAW264.7 cells via the miR-181b/HMGB1/TRL4/NF-kappaB pathway.
lncRNA target	34650684	hsa-mir-516a	Leukemia, Myeloid, Acute	CONCLUSION: Decreased expression of circMYC could suppress AML progression by regulating miR-516a-5p/AKT3, suggesting a new therapeutic target in AML treatment.
lncRNA target	34650682	hsa-mir-34b	Dementia, Vascular	CONCLUSION: MIAT-containing exo from HNSCs can improve cognitive disorders in VD rats via the miR-34b-5p/CALB1 axis.
lncRNA target	34650682	hsa-mir-34b	Cognition Disorders	CONCLUSION: MIAT-containing exo from HNSCs can improve cognitive disorders in VD rats via the miR-34b-5p/CALB1 axis.
genetics_knock down_promote	34650680	hsa-mir-542	Colorectal Neoplasms	3p or the overexpression of CREB1 is able to partly weaken the inhibition of CRC cells through the circ_002178 knockdown.
transcription factor target	34650661	hsa-mir-101	Intervertebral Disc Degeneration	Our findings demonstrated that miR3p alleviated IDD process through the STC1/VEGF/MAPK pathway.
other	34650644	hsa-mir-132	Cardiomyopathies	miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6.
other	34650644	hsa-mir-132	Sepsis	miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6.
other	34650644	hsa-mir-223	Cardiomyopathies	miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6.
other	34650644	hsa-mir-223	Sepsis	miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6.
transcription factor target	34650631	hsa-mir-124	Myocardial Infarction, Acute	Together with the GSEA results, which indicated that the differentially expressed genes were mainly enriched in the angiogenesis-inhibiting PI3K/AKT signaling pathway, the present study reported that high expression of miR-124 was negatively associated with patients with AMI, promoting the apoptosis and suppressing the proliferation of vessel endothelial cells.
lncRNA target	34649611	hsa-mir-136	Ovarian Neoplasms	CONCLUSIONS: Circ_0061140 silencing repressed the progression and PTX resistance of ovarian cancer by downregulating CBX2 expression via sponging miR-136, which provided novel insight into studying the therapy of ovarian cancer with PTX.
genetics_knock down_promote	34649592	hsa-mir-98	Diabetic Nephropathies	Also, NOTCH2 knockdown partly reversed miR
lncRNA target	34649564	hsa-mir-31	Osteoarthritis	3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA.
lncRNA target	34649564	hsa-mir-31	Hypoadrenocorticism, Familial	3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA.
other	34649241	hsa-mir-149	Coronary Artery Disease	The expression patterns of circ_ROBO2 and miR-149 in CAD patients and PDGF-BB-treated human aortic smooth muscle cells (HASMCs) were upregulated and downregulated, respectively.
circulation_biomarker_diagnosis_up	34648865	hsa-mir-186	Depression	Our results indicate that the exosomal SERPINF1 in peripheral blood could serve as a reliable biomarker indicating MDD development, and miR
circulation_biomarker_diagnosis_up	34648162	hsa-mir-369	Nephritis, Interstitial	Immunofluorescence, qRT-PCR, and western blot were performed to detect the expression of miR-369, Th1/Th2 biomarkers, endoplasmic reticulum (ER) stress-related genes, and apoptotic genes.
lncRNA target	34648132	hsa-mir-7	Siderosis	Our results indicate that selectively inhibiting ferroptosis mediated by a METTL14/KCNQ1OT1/miR
lncRNA target	34648132	hsa-mir-7	Heart Injuries	Our results indicate that selectively inhibiting ferroptosis mediated by a METTL14/KCNQ1OT1/miR5p positive feedback loop in cardiomyocytes could provide a new therapeutic approach to control DOX-induced cardiac injury.
other	34647653	hsa-mir-449	Intestinal-Type Sinonasal Adenocarcinoma	CONCLUSIONS: A high expression of miR-205 and miR-449 is independent predictors of poor survival for ITAC patients.
other	34647653	hsa-mir-205	Intestinal-Type Sinonasal Adenocarcinoma	CONCLUSIONS: A high expression of miR-205 and miR-449 is independent predictors of poor survival for ITAC patients.
other	34647573	hsa-mir-136	Lung Neoplasms	5p/HuR in lung cancer and provide novel evidence for the importance of circRNA as a ceRNA in tumorigenesis.
genetics_GWAS	34647497	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively.
genetics_GWAS	34647497	hsa-mir-375	Squamous Cell Carcinoma of Head and Neck	MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively.
other	34647243	hsa-mir-185	Venous Thrombosis	However, no study has reported the effect of miR-185 on LEDVT. Here, we studied the effects of miR-185 on the PI3K/AKT and MAPK signaling pathways in the LEDVT cells.
genetics_knock down_promote	34647226	hsa-mir-3173	Cholangiocarcinoma	Knockdown of SNHG3 expression suppressed malignant phenotypes in CCA cells via the miR
other	34647185	hsa-mir-1	Carcinoma, Squamous Cell, Cutaneous	MicroRNA21 and microRNA31 are involved in posttranscriptional regulation of protein expression and could play a relevant role in EMT and cSCC progression. Eight tissue microarrays from 80 consecutive cSCCs were analyzed using LNA-based miRNA in situ hybridization for miRNA21 and miRNA31 evaluation, and immunohistochemistry for MMP-1, MMP-3, PTEN, NOTCH-1, NF-kappaB, p63 and CD31.
other	34647185	hsa-mir-21	Carcinoma, Squamous Cell, Cutaneous	MicroRNA21 and microRNA31 are involved in posttranscriptional regulation of protein expression and could play a relevant role in EMT and cSCC progression. Eight tissue microarrays from 80 consecutive cSCCs were analyzed using LNA-based miRNA in situ hybridization for miRNA21 and miRNA31 evaluation, and immunohistochemistry for MMP-1, MMP-3, PTEN, NOTCH-1, NF-kappaB, p63 and CD31.
lncRNA target	34646884	hsa-mir-204	Retinal Diseases	Continuous bioinformatics analysis has shown that miR-204 has a significant presence and expression in retinal tissue, and approximately 293 genes are controlled and regulated by miR-204 in this tissue; also, target genes of miR-204 have the potential to develop various retinopathies; thus, a study of related target genes can provide appropriate treatment strategies in the future.
other	34646766	hsa-mir-1271	Breast Neoplasms	3p, miR-487a, and miR-487b as EZH2 regulators.
other	34646755	hsa-mir-944	Papillomavirus Infections	From the network, we also noticed that EGFR is regulated by HPV E7 protein and hsa-miR-944.
circRNA target	34646428	hsa-mir-92a-2	Carcinoma, Renal Cell	Thus, targeting the novel circAMOTL1L-miR-92a
lncRNA target	34646427	hsa-mir-128	Heart Failure	These results indicate that miR-128 inhibition might be a potent therapeutic strategy for maladaptive cardiac remodeling and heart failure.
lncRNA target	34646427	hsa-mir-128	Ventricular Remodeling	The aim of the present study was to investigate the role of miR-128 in chronic angiotensin II (Ang II) infusion-induced cardiac remodeling and its underlying mechanism. These results indicate that miR-128 inhibition might be a potent therapeutic strategy for maladaptive cardiac remodeling and heart failure.
other	34646427	hsa-mir-128	Cardiomegaly	In vitro experiments of cardiac hypertrophy, apoptosis, and aberrant autophagy were performed in cultured cells after Ang II treatment or transfection of miR-128 antagomir.
genetics_overexpression_promote	34646424	hsa-mir-505	Osteoarthritis	While overexpression of circFAM160A2 decreased the production of extracellular matrix (ECM) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of miR
circulation_biomarker_diagnosis_down	34646415	hsa-mir-382	Atherosclerosis	5p in atherosclerotic serum samples.
exosome	34646393	hsa-mir-124	Glioblastoma	Conclusions: In this study, we demonstrated that EV-mediated miR-124 delivery exerted synergistic anti-tumor effects by suppressing the growth of human GBM cells and inhibiting M2 microglial polarization.
other	34646160	hsa-mir-23a	Heart Failure	In HFrEF patients, baseline miR-23a predicted VO(2)peak response to training.
other	34645975	hsa-mir-432	Breast Neoplasms	Taken together, DRAIC sponged miR5p to enhance SLBP expression, by which malignant behaviors of BRCA cells were promoted.
genetics_knock down_promote	34645476	hsa-mir-545	Colorectal Neoplasms	3p was a target of circ_0026416, and rescue experiments indicated that circ_0026416 knockdown blocked CRC development by enriching miR
other	34645448	hsa-mir-146a	Periodontitis	CONCLUSIONS: The results of this study failed to show the associations of miR-146a level with OPG and RANKL levels and OPG/RANKL ratio in periodontitis after non-surgical periodontal treatment.
other	34644734	hsa-mir-582	Melanoma	3p/E2F3 axis.
lncRNA target	34644678	hsa-mir-188	Adenocarcinoma of Lung	Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing LUAD proliferation, invasion, and migration by inhibiting miR
lncRNA target	34644206	hsa-mir-122	Carcinoma, Hepatocellular	sponge and miR-122 using virus-like particles modified by cell-specific peptides is an effective and convenient strategy to correct microRNA dysregulation in hepatocellular carcinoma cells and is a promising therapeutic strategy for hepatocellular carcinoma.
genetics_GWAS	34643920	hsa-mir-149	Thyroid Neoplasms	CONCLUSIONS: miRNA-149 gene SNP rs2292832 was observed in strong association with thyroid cancer.
circulation_biomarker_diagnosis_ns	34643918	hsa-mir-770	Foot Ulcer	5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients.
circulation_biomarker_diagnosis_ns	34643918	hsa-mir-571	Foot Ulcer	5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients.
circulation_biomarker_diagnosis_ns	34643918	hsa-mir-571	Diabetes Mellitus, Type 2	5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients.
circulation_biomarker_diagnosis_ns	34643918	hsa-mir-770	Diabetes Mellitus, Type 2	5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients.
other	34643431	hsa-mir-2187	Rhabdoviridae Infections	Upon Siniperca chuatsi rhabdovirus (SCRV) virus infection, the expression levels of MIR2187HG were remarkably enhanced.
lncRNA target	34643375	hsa-mir-92a	Colorectal Neoplasms	The in vivo and in vitro experimental results showed that LINC01915 inhibited the uptake of CRC-derived EVs by NFs through the miR-92a-3p/KLF4/CH25H axis, thus arresting the angiogenesis and the conversion of NFs into CAFs and in turn prevent tumor growth. These data together supported the inhibiting role of LINC01915 in the conversion of NFs into CAFs triggered by the CRC-derived EVs and the ensuing tumor growth, which may be related to its regulation on the miR-92a-3p/KLF4/CH25H axis.
lncRNA target	34643249	hsa-mir-375	Glioma	The present study demonstrated that silencing LINC01138 inhibited aerobic glycolysis and thus reduced glioma cell proliferation, potentially by modulating the miR375/SP1 axis.
lncRNA target	34643247	hsa-mir-373	Prostatic Neoplasms	The results demonstrated that the expression levels of SNHG16 and TGFbetaR2 were significantly upregulated in PCa tissues, whereas miR3733p expression was significantly downregulated (P<0.001). Taken together, the results of the present study suggest that SNHG16 promotes the proliferation and migration of PCa cells by targeting the miR3733p/TGFbetaR2/SMAD axis.
lncRNA target	34643245	hsa-mir-153	Lung Neoplasms	In conclusion, HHIPAS1 inhibits the EMT and stemness of lung cancer cells by regulating the miR1533p/PCDHGA9 axis.
other	34643214	hsa-mir-940	Squamous Cell Carcinoma of Head and Neck	Functional bioinformatics analysis and dual-luciferase reporter assay revealed that E2F2 rs2075993 T>C reduced the stability of E2F2 3'-UTR secondary structure and affected the binding of E2F2 to miR-940, which was up-regulated in HNSCC tumor tissues (P = 2.9e-8) and was correlated with poor overall survival of HNSCC (HR = 1.39, 95% CI = 1.02-1.90).
genetics_knock down_promote	34643163	hsa-mir-137	Carcinoma, Renal Cell	Further functional studies demonstrated that the inhibition effect of NNT-AS1 knockdown on ccRCC carcinogenesis could be partially reversed by overexpression of YBX-1, suggesting that NNT-AS1 promotes ccRCC progression through the miR-137/YBX-1 pathway.
transcription factor target	34643044	hsa-mir-146b	Atrial Fibrillation	The expression of miR-146b-5p, whose the targeted gene is TIMPs, is upregulated in atrial cardiomyocytes during AF.
transcription factor target	34643044	hsa-mir-146b	Fibrosis, Atrial	The expression of miR-146b-5p, whose the targeted gene is TIMPs, is upregulated in atrial cardiomyocytes during AF.
lncRNA target	34643030	hsa-mir-607	Lung Neoplasms	The LINC00115/miR-607/ITGB1 signaling axis might be a novel therapeutic target in lung cancer.
other	34641879	hsa-mir-125a	Adenocarcinoma of Lung	Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p.
lncRNA target	34641738	hsa-mir-21	Diabetic Nephropathies	In this study, we have investigated the role of miR-21 on l-thyroxine (l-Thy)-induced cardiac fibrosis in rats. In conclusion, l-Thy-induced LV remodeling and fibrosis include a ROS-dependent upregulation of miR-21 which in turns activates NF-kappaB/NRLP3 inflammasome and suppresses SMad7.
lncRNA target	34641698	hsa-mir-424	Urinary Bladder Neoplasms	LINC00355 promoted migration, invasion, and EMT ability of bladder cancer through elevating HMGA2 expression via acting as a sponge for miR
circulation_biomarker_diagnosis_up	34641696	hsa-mir-27b	Stomach Neoplasms	The results showed that hsa_circ_0006470 expression was significantly elevated in GC cells, which was mainly distributed in cytoplasmic components and could directly bind with miR-27b-3p in GC cells.
genetics_GWAS	34641388	hsa-mir-155	COVID-19	dioca aqueous extract, ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were recorded through measuring TNF-alpha, IL-1beta, IL-2, IL-10, G-CSF, and genetic expression of miRNA 21-3P and miRNA-155 levels to assess their anti-inflammatory effects essential for COVID-19 patients.
genetics_GWAS	34641388	hsa-mir-21	COVID-19	dioca aqueous extract, ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were recorded through measuring TNF-alpha, IL-1beta, IL-2, IL-10, G-CSF, and genetic expression of miRNA 21-3P and miRNA-155 levels to assess their anti-inflammatory effects essential for COVID-19 patients.
tissue_expression_ns	34639126	hsa-mir-223	Thiamine Deficiency	The mechanism research revealed that BAP31-deficiency decreased Nrf2 mRNA stability (half-life of Nrf2 mRNA decreased from ~1.3 h to ~40 min) and miR-223 expression, led to reduced nuclear factor erythroid 2-related factor 2 (Nrf2) signaling activation and antioxidant genes induction.
transcription factor target	34639051	hsa-mir-24	Heart Failure	In conclusion, HF progression following DOX administration can be prevented or even delayed by targeting miR-24 and its downstream JP-2.
other	34638938	hsa-mir-483	Gastrointestinal Stromal Tumors	Using an extended series of GIST samples, we further validated the downregulation of miR3p in imatinib-treated GIST samples by RT-qPCR.
transcription factor target	34638915	hsa-mir-29a	Cardiomyopathies	miR-29a-3p targeted THBS2 expression via a direct anti-fibrotic effect on PAH-induced cardiac fibrosis, indicating miR-29a-3p acts as a messenger with promising therapeutic effects.
circulation_biomarker_diagnosis_ns	34638892	hsa-mir-126	Renal Insufficiency, Chronic	miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease.
other	34638892	hsa-mir-9	Renal Insufficiency, Chronic	An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39.
lncRNA target	34638868	hsa-mir-155	Cardiovascular Diseases	Taken together, these results are the first to elucidate the role of HDAC6 in unloading-induced cell growth inhibition through the miR
other	34638838	hsa-mir-28	Diabetic Retinopathy	A panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR3p) demonstrated a good sensitivity and specificity for predicting T2DR.
other	34638838	hsa-let-7a	Diabetic Retinopathy	A panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR3p) demonstrated a good sensitivity and specificity for predicting T2DR.
circulation_biomarker_diagnosis_ns	34638717	hsa-mir-22	Heart Failure	In conclusion, circulating miR-199a-5p and miR
circulation_biomarker_diagnosis_ns	34638717	hsa-mir-199a	Heart Failure	In conclusion, circulating miR-199a-5p and miR
circulation_biomarker_diagnosis_ns	34638717	hsa-mir-199a	Atrial Fibrillation	In conclusion, circulating miR-199a-5p and miR
circulation_biomarker_diagnosis_ns	34638717	hsa-mir-22	Atrial Fibrillation	In conclusion, circulating miR-199a-5p and miR
other	34638691	hsa-mir-20a	Respiratory Insufficiency	In conclusion, our analysis underlines the importance of thromboembolic processes in patients with respiratory failure and emphasizes miRNA-320s as potential biomarkers for severe progressive SARS-CoV-2 infection.
other	34638691	hsa-mir-20a	COVID-19	In conclusion, our analysis underlines the importance of thromboembolic processes in patients with respiratory failure and emphasizes miRNA-320s as potential biomarkers for severe progressive SARS-CoV-2 infection.
exosome	34638684	hsa-mir-221	Obesity, Maternal	miRNA detection showed that miR-221, one of the miRNAs, was significantly enriched in exosomes from obese sows.
lncRNA target	34638550	hsa-mir-21	Colorectal Neoplasms	The elevation of miR21 expression was upstream of the phosphatase and tensin homolog (PTEN) inhibition, and CRC cell proliferation enhancement that was shown to be possibly mediated by PI3K/AKT signaling activation.
other	34638505	hsa-mir-552	Colorectal Neoplasms	Finally, we identified that microRNA miR-552 negatively regulates ACKR4 expression in human CRC.
lncRNA target	34638504	hsa-mir-200c	Prostatic Neoplasms, Castration-Resistant	Mechanistically, we found that: (1) TBX2 binds to the promoter and represses the expression of miR-200c-3p, a miR reported to be lost in castrate resistant prostate cancer (CRPC), and (2) the repression of miR-200c-3p results in the increased expression of its targets SOX2 and N-MYC.
other	34638487	hsa-mir-199b	Rectal Neoplasms	microRNA-199b as A Promising Predictor of Outcome and Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer Patients.
target gene	34638478	hsa-mir-27a	Colorectal Neoplasms	The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells.
other	34638467	hsa-mir-21	Inflammation	In the liver, miR-21 was reported to promote hepatic steatosis and inflammation, but whether miR-21 also drives hepatocarcinogenesis remains poorly investigated in vivo.
other	34638467	hsa-mir-21	Fatty Liver	In the liver, miR-21 was reported to promote hepatic steatosis and inflammation, but whether miR-21 also drives hepatocarcinogenesis remains poorly investigated in vivo.
target gene	34638401	hsa-mir-125b	Carcinoma, Hepatocellular	In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients.
other	34638231	hsa-mir-145	Penile Neoplasms	5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy.
other	34638231	hsa-mir-487b	Penile Neoplasms	5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy.
other	34638231	hsa-mir-432	Penile Neoplasms	5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy.
lncRNA target	34637688	hsa-mir-1224	Polycystic Ovary Syndrome	5p might be a promising target for treating PCOS.
lncRNA target	34637682	hsa-mir-628	Stomach Neoplasms	Our findings identify a novel ceRNA network, the circ_HN1/miR5p/NT5E axis, for the oncogenic activity of circ_HN1 in gastric cancer, highlighting circ_HN1 inhibition as a promising targeted treatment against gastric cancer.
other	34637672	hsa-mir-127	Osteosarcoma	In conclusion, circFOXP1 promoted angiogenesis by regulating miR5p/CDKN2AIP signaling pathway in osteosarcoma.
circulation_biomarker_diagnosis_ns	34637043	hsa-mir-483	Pneumonia	The expression of serum miR
circulation_biomarker_diagnosis_ns	34637043	hsa-mir-483	Respiratory Insufficiency	The expression of serum miR
exosome	34637033	hsa-mir-223	Periodontitis	3p expression in salivary exosomes could be used as an important non-invasive method to diagnose and evaluate the severity of periodontitis.
transcription factor target	34636482	hsa-mir-34c	Sialorrhea	The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1.
transcription factor target	34636482	hsa-mir-34b	Sialorrhea	The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1.
transcription factor target	34636482	hsa-mir-34c	Respiratory Syncytial Virus Infections	The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. This study identified that miR-34b/miR-34c was involved in c-Jun-regulated MUC5AC production by targeting FGFR1 in RSV-infected airway epithelial cells.
transcription factor target	34636482	hsa-mir-34b	Respiratory Syncytial Virus Infections	The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. This study identified that miR-34b/miR-34c was involved in c-Jun-regulated MUC5AC production by targeting FGFR1 in RSV-infected airway epithelial cells.
lncRNA target	34636432	hsa-mir-126	Lung Neoplasms	Paeonol inhibits human lung cancer cell viability and metastasis via the miR
other	34636395	hsa-mir-214	Carcinoma, Hepatocellular	These findings suggest that the BACE1-AS/miR3p/APLN axis is a novel signaling pathway that facilitates HCC.
other	34636389	hsa-mir-146a	Depression	In addition, curcumin attenuated the increases in levels of miR-146a-5p and decreases in the expression of p-ERK signaling that would normally occur within CA1 regions of these depressed rats.
transcription factor target	34636136	hsa-mir-363	Glioma	3p expression inhibited glioma cell proliferation and invasion, as well as promoted cell death via attenuating EMT and blocking the Wnt/beta-catenin pathway.
genetics_overexpression_promote	34636093	hsa-mir-29a	Ameloblastoma	RESULTS: miR-29a-3p was overexpressed in AB tissues, which promoted the migration and invasion of AB cells in vitro.
other	34635862	hsa-mir-494	Spinal Cord Injuries	As confirmed by existing studies, miR-494 is important to regulate the occurrence, progression, and repair of spinal cord injury (SCI).
exosome	34635639	hsa-mir-1305	Colorectal Neoplasms	Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-beta2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes.
transcription factor target	34635014	hsa-mir-19b	Adenocarcinoma of Lung	These findings suggested miR-19b-3p/GNG7 axis contributed to the progression of LUAD through Hedgehog signaling, which might be a potential therapeutic target for LUAD treatment.
lncRNA target	34635009	hsa-mir-409	Osteosarcoma	In conclusion, circATRNL1 promoted osteosarcoma progression by enhancing glycolysis via circATRNL1/miR
other	34634995	hsa-mir-144	Carcinoma, Hepatocellular	3p/WTAP axis as downstream effectors mediating the oncogenic function of LINC00839.
exosome	34634686	hsa-mir-501	Urinary Incontinence, Stress	Collectively, our present results provide new insights into the promyogenic mechanism of M2 macrophages and prove that M2 macrophage exosomal miR-501 may represent a potential therapeutic to promote recovery from diseases caused by muscle injury, including SUI.
exosome	34634686	hsa-mir-501	Muscular Diseases	Collectively, our present results provide new insights into the promyogenic mechanism of M2 macrophages and prove that M2 macrophage exosomal miR-501 may represent a potential therapeutic to promote recovery from diseases caused by muscle injury, including SUI.
genetics_overexpression_promote	34634673	hsa-mir-587	Adenocarcinoma of Lung	Functional assays revealed that circZMYM4 overexpression suppressed LUAD cell proliferation, metastasis and suppressed apoptosis, while miR-587 overexpression could weaken these effects.
exosome	34634611	hsa-mir-27a	Hemangioma, Cavernous	Here, we aimed to investigate the relationship between TAMs-derived exosomal miR-27a-3p and propranolol sensitivity in IH.
circulation_biomarker_diagnosis_ns	34633737	hsa-mir-687	Liver Injury	NEW FINDINGS What is the central question of this study? What is the role of circulating exosomal miR-687 in remote hepatic injury following renal ischaemia-reperfusion injury (IRI) and does thymoquinone have a modulatory impact? What is the main finding and its importance? Exosomal miR-687 was expressed in renal IRI, entered the circulation and was deposited in the liver.
genetics_knock down_promote	34633608	hsa-mir-138	Retinoblastoma	5p overexpression-mediated effects in RB cells.
transcription factor target	34633468	hsa-mir-451	Myocardial Reperfusion Injury	CONCLUSIONS: miR3p played a protective role in MIRI via inhibiting MAP1LC3B-mediated autophagy, which may provide new molecular targets for the treatment of MIRI and further improves the clinical outcomes of heart diseases.
genetics_knock down_promote	34633248	hsa-mir-101	Osteoarthritis	3p using bioinformatics analysis and luciferase reporter assays, performed loss- and gain-of-function analyses.
other	34633138	hsa-mir-424	Osteochondrodysplasias	Moreover, miR-424/503 cluster is required for Wnt-mediated MaSC expansion induced by the ovarian cycles. These results unveil an unknown link between the miR-424/503, regulation of Wnt signaling, MaSC fate, and tumorigenesis.
lncRNA target	34633056	hsa-mir-29c	Carcinoma, Hepatocellular	Collectively, the results of the present study revealed that CRNDE was upregulated and exerted an oncogenic role in HCC by targeting miR29c3p, and that the upregulation of CRNDE also promoted NASP expression.
lncRNA target	34633056	hsa-mir-29c	Colorectal Neoplasms	Collectively, the results of the present study revealed that CRNDE was upregulated and exerted an oncogenic role in HCC by targeting miR29c3p, and that the upregulation of CRNDE also promoted NASP expression.
lncRNA target	34632963	hsa-mir-1322	Colorectal Neoplasms	nucleatum infection decreased the expression of miR-1322 by activating the NF-kappaB signaling pathway in CRC cells. nucleatum promotes CRC metastasis through the miR-1322/CCL20 axis and M2 polarization.
genetics_overexpression_promote	34632938	hsa-mir-199a	Adenocarcinoma of Lung	Additionally, miR-199a-3p overexpression inhibited the growth of LUAD cells in vitro and in vivo, while elevating the apoptosis rate of the cells.
genetics_overexpression_promote	34632932	hsa-mir-188	Myocardial Ischemia	Silencing LncGAS5 and SMAD2 or overexpressing miR
lncRNA target	34632867	hsa-mir-23b	Osteosarcoma	Upregulation of miR-23b-3p not only inhibited the expression of ADD3, but also released the tumor suppressive role of ADD3 on the proliferation and migration of osteosarcoma cells.
genetics_knock down_promote	34632534	hsa-mir-590	Breast Neoplasms	5p inhibition reversed the inhibitory effects of circ_0069718 knockdown on BC cell-aggressive oncogenic phenotypes; moreover, miR
lncRNA target	34632168	hsa-mir-499a	Ischemic Stroke	This study aimed to test our hypothesis that a miR-499a played an important role in the inflammatory response in astrocytes induced by IS targeting phosphatase and tensin homologue deleted on chromosome 10 (PTEN).
genetics_GWAS	34632051	hsa-mir-16	Cholangiocarcinoma	Taken together, our new findings suggested that IDH1 mutation-induced R-2HG could suppress CCA growth via regulating the FTO/m6A-methylated ERalpha/miR16-5p/YAP1 signaling pathway.
lncRNA target	34631898	hsa-mir-145	Stomach Neoplasms	Inhibition of circCOL1A1/miR-145/RABL3 could effectively suppress gastric cancer cell proliferation, migration, and invasion.
circulation_biomarker_diagnosis_up	34631883	hsa-mir-92a	Endometriosis	3p in both plasma and eMSCs and revealed their possible role in endometriosis based on in silico analysis.
target gene	34631548	hsa-mir-135a	Multiple Myeloma	Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis.
other	34631347	hsa-mir-6791	Breast Neoplasms	Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness.
other	34631347	hsa-mir-6844	Breast Neoplasms	The miR-6844 showed significantly high expression in various clinical subgroups of invasive breast cancer patients compared with the normal samples. Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness.
other	34631347	hsa-mir-4419a	Breast Neoplasms	Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness.
other	34631347	hsa-mir-4251	Breast Neoplasms	Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness.
other	34631281	hsa-mir-4677	Arteriosclerosis Obliterans	3p/USP9X axis to accelerate the proliferation and migration of VSMCs in the in vitro model of ASO of the lower extremities.
other	34631281	hsa-mir-889	Arteriosclerosis Obliterans	3p/USP9X axis to accelerate the proliferation and migration of VSMCs in the in vitro model of ASO of the lower extremities.
circRNA target	34631278	hsa-mir-326	Glioblastoma	5p/SMAD6 signaling axis could be a potential target for GBM treatment.
circRNA target	34631278	hsa-mir-30	Glioblastoma	5p/SMAD6 signaling axis could be a potential target for GBM treatment.
lncRNA target	34631276	hsa-mir-20a	Diabetes Mellitus	However, the direct role of miR-320a in the pathophysiology of pancreatic beta cells under diabetes mellitus remains unclear. Our data suggested that miR-320a could damage the pancreatic beta cells directly and might be a potential therapeutic target of diabetes.
other	34631221	hsa-mir-210	Colorectal Neoplasms	Therefore, the HIF-1alpha/miR-210/VMP1 pathway might regulate the migration and invasion of CAFs in CRC.
lncRNA target	34631221	hsa-mir-210	Double Outlet Right Ventricle	In vivo, inhibition of miR-210 expression in CAFs reduced the metastasis of CAFs and tumour cells.
other	34630982	hsa-mir-511	Goiter	The results showed that SHB prescription ameliorated goiter and downregulated miR3p.
genetics_overexpression_suppress	34630738	hsa-mir-141	Ulcerative   Colitis	In summary, the overexpression of H19 in MSC downregulated miR-139 and miR-141, thus increasing the activity of their targets ICAM-1 and CXCR4, respectively, to exhibit therapeutic effects in ulcerative colitis.
genetics_overexpression_suppress	34630738	hsa-mir-139	Ulcerative   Colitis	In summary, the overexpression of H19 in MSC downregulated miR-139 and miR-141, thus increasing the activity of their targets ICAM-1 and CXCR4, respectively, to exhibit therapeutic effects in ulcerative colitis.
genetics_overexpression_promote	34630715	hsa-mir-135a	Carcinoma, Hepatocellular	Notably, overexpression of TONSL-AS1 inhibited HCC cell proliferation, while overexpression of miR-135a promoted HCC cell proliferation and decreased the effect of overexpression of TONSL-AS1 on cell proliferation. Taken together, the results of the present study suggest that miR-135a expression is upregulated in HCC and targets lncRNA TONSL-AS1 to suppress cell proliferation.
genetics_GWAS	34630712	hsa-mir-152	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_GWAS	34630712	hsa-mir-34b	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_GWAS	34630712	hsa-mir-200a	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_GWAS	34630712	hsa-mir-34c	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_GWAS	34630712	hsa-mir-200b	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_GWAS	34630712	hsa-mir-148a	Prostatic Neoplasms	The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR.
genetics_knock down_promote	34630709	hsa-mir-204	Squamous Cell Carcinoma of Head and Neck	Knockdown of NEAT1 using small interfering (si) RNA and overexpressed miR
genetics_overexpression_promote	34630706	hsa-mir-34b	Leukemia, Myeloid, Acute	Moreover, AML cell proliferation was increased by circ-ATAD1 overexpression, but decreased by miR-34b overexpression, and the effect of circ-ATAD1 overexpression on AML cell proliferation was reduced by miR-34b overexpression.
circulation_biomarker_prognosis_ns	34630703	hsa-mir-210	Carcinoma, Non-Small-Cell Lung	The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR
circulation_biomarker_prognosis_ns	34630703	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR
circulation_biomarker_prognosis_ns	34630703	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR
circulation_biomarker_prognosis_ns	34630703	hsa-mir-1290	Carcinoma, Non-Small-Cell Lung	The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR
genetics_overexpression_suppress	34630696	hsa-mir-665	Retinoblastoma	Furthermore, the proliferation and migratory and invasive abilities of Rb Y79 and HXO-RB44 cells were decreased following MIAT downregulation or miR-665 overexpression.
lncRNA target	34630694	hsa-mir-23b	Osteoporosis	In conclusion, lncRNA RP11-84C13.1 upregulated RUNX2 by absorbing miRNA-23b-3p, and thus induced hBMSC osteogenesis to alleviate osteoporosis.
target gene	34630682	hsa-mir-515	Breast Neoplasms	miR-515-5p inhibits the proliferation, migration and invasion of human breast cancer cells by targeting CBX4.
transcription factor target	34630677	hsa-mir-489	Inflammation	3p may represent a novel therapeutic target for the treatment of IDD.
target gene	34630673	hsa-mir-638	Ovarian Neoplasms	miR-638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells.
lncRNA target	34630672	hsa-mir-18a	Cicatrix	Therefore, miR-18a-5p may serve as a novel therapeutic target for the treatment of HS.
genetics_overexpression_promote	34630658	hsa-mir-144	Nasopharyngeal Carcinoma	Furthermore, the downregulation of IRS-1 by miR-144 decreased the expression level of dishevelled 2 (Dvl2) protein without affecting its mRNA level, and Dvl2 overexpression abolished the inhibitory effect of the miR-144 mimic in NPC, indicating that miR-144 potentially regulates NPC by indirectly regulating Dvl2.
lncRNA target	34630643	hsa-mir-24	Myocardial Reperfusion Injury	Overall, the present results suggested that miR-24 improves myocardial injury in rats by inhibiting the NF-kappaB/TNF-alpha pathway.
genetics_knock down_promote	34630639	hsa-mir-1181	Carcinoma, Non-Small-Cell Lung	In addition, overexpression of miR-1181 exerted enhancing effects on cell proliferation, migration and invasion of NSCLC, while its knockdown inhibited these cellular processes.
other	34630590	hsa-mir-21	Leishmaniasis	BACKGROUND: Leishmaniasis is characterized by strong inflammatory responses with high levels of inflammatory cytokines that induce microRNA 21 and matrix metalloproteinases.
lncRNA target	34630130	hsa-mir-204	Pre-Eclampsia	The network connecting the 37 target genes for miR5p revealed pathways of known pathophysiological relevance during the early development of PE and included key genes related to PE, such as BDNF, MMP-9, MALAT1, TGFBR2, and SIRT1.
lncRNA target	34630099	hsa-mir-204	Insulinoma	Therefore, we speculate that miR-204 may be the upstream regulatory target of SIRT1 in islets and thus participate in the occurrence of beta-cell dysfunction.
genetics_overexpression_promote	34630099	hsa-mir-204	Hyperlipoproteinemia Type III	SIRT1 overexpression reversed the damage to beta-cells caused by miR-204.
other	34630099	hsa-mir-204	Diabetes Mellitus, Type 2	Our study identifies a novel correlation between miR-204 and beta-cell dysfunction in T2DM and shows that administration of BBR leads to remission of beta-cell dysfunction by regulating the miR-204/SIRT1 pathway.
genetics_knock down_suppress	34629901	hsa-mir-144	Stomach Neoplasms	CONCLUSION: HCG11 knockdown attenuated DDP resistance of GC cells through via miR
other	34629898	hsa-mir-215	Carcinoma, Hepatocellular	The prediction of lncRNA RUSC1-AS1/hsa-miR5p/LRP1B axis by bioinformatics may be the potential mechanism underlying LRP1B's effect on HCC prognosis and progression.
lncRNA target	34629895	hsa-mir-338	Brain Ischemia	CASC15/miR3p/ETS1 axis played an essential role in cell viability, apoptosis, and neuroinflammation.
lncRNA target	34629895	hsa-mir-338	Ischemic Stroke	CASC15/miR3p/ETS1 axis played an essential role in cell viability, apoptosis, and neuroinflammation.
exosome	34629821	hsa-mir-588	Stomach Neoplasms	CONCLUSION: In conclusion, we uncovered that exosomal miR-588 from M2 macrophages contributes to DDP resistance of gastric cancer cells by partly targeting CYLD.
lncRNA target	34629820	hsa-mir-20b	Colorectal Neoplasms	In addition, miR-20b-3p expression in CRC patients was also reduced and negatively correlated with circ_0084927 expression. Moreover, circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/ AKT/mTOR pathway.
lncRNA target	34629748	hsa-mir-200b	Inflammatory Bowel Diseases	MiR-200b-3p alleviates UC by negatively regulating KHDRBS1.
transcription factor target	34629418	hsa-mir-16	Macular Degeneration	We hypothesize that Hsa-miR5p might target four out of the five key DEGs in the AMD RPE.
circulation_biomarker_diagnosis_ns	34629299	hsa-mir-371a	Testicular Neoplasms	CONCLUSION: Quantifying circulating miR-371a-3p alone is sufficient for testicular MGCT diagnosis.
genetics_GWAS	34629216	hsa-mir-143	Glomus Tumor	In fact, glomus tumor involves frequent MIR143-NOTCH gene fusion whereas others pericytic tumor (myopericytoma and myofibroma) involve mutations of PDGFRB gene. Next Generation molecular analysis using RNA sequencing highlighted the characteristic MIR143-NOTCH gene fusion witch supports the diagnosis of glomus tumor.
circulation_biomarker_diagnosis_up	34629107	hsa-mir-1260b	Ovarian Neoplasms	We investigated the expression levels of miR-1260a, and miR-1260b miRNAs, in the peripheral blood lymphocytes of 150 familial and sporadic ovarian cancer patients, and of 100 healthy individuals of the control group who were matched for age, sex, and ethnicity with the patient group, and investigated their possible property of being a biologic indicator for ovarian cancer.
other	34629037	hsa-mir-7	Osteoarthritis	In summary, miR-7/EGFR/MEGF9 axis may perform a crucial function in the regulation of OA, providing potential for OA treatment.
genetics_knock down_promote	34628789	hsa-mir-21	Glioma	In rescue experiments, knockdown of TET1 neutralized miR
lncRNA target	34628519	hsa-mir-582	Melanoma	Low expression of miR-582 is associated with prognosis and progression of melanoma by targeting FOXC1.
lncRNA target	34628269	hsa-mir-9	Osteoarthritis	5p was highly expressed in the synovial tissues of the OA model and was positively associated with M1 markers.
circulation_biomarker_diagnosis_ns	34628264	hsa-mir-150	Carcinoma, Renal Cell	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	34628264	hsa-mir-145	Carcinoma, Renal Cell	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	34628264	hsa-mir-21	Carcinoma, Renal Cell	RESULTS: Six serum miRNAs (miR
circulation_biomarker_diagnosis_ns	34628264	hsa-mir-146a	Carcinoma, Renal Cell	RESULTS: Six serum miRNAs (miR
genetics_GWAS	34628001	hsa-mir-206	Depression	In contrast, both genetic knockdown of hippocampal miR
genetics_knock down_suppress	34627697	hsa-mir-153	Atherosclerosis	CONCLUSION: PVT1 knockdown alleviated ox-LDL-induced vascular endothelial cell injury and atherosclerosis through miR3p/GRB2 axis via ERK1/2 and p38 pathway.
lncRNA target	34627683	hsa-let-7b	Hodgkin Disease	Let-7b-5p holds the central position in the regulatory network of miRNA-mRNA interactions, has the highest number of mRNA target genes shared with the other differentially expressed miRNAs and is significantly downregulated in Hodgkin lymphoma follicular fluid samples.
circulation_biomarker_diagnosis_up	34627442	hsa-mir-205	Thrombocytopenia	5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups.
circulation_biomarker_diagnosis_up	34627442	hsa-mir-138	Thrombocytopenia	5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups.
circulation_biomarker_diagnosis_up	34627442	hsa-mir-1827	Thrombocytopenia	5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups.
circulation_biomarker_diagnosis_up	34627442	hsa-mir-107	Thrombocytopenia	5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups.
lncRNA target	34627424	hsa-mir-652	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5p and deregulates the translational inhibition of P62 mRNA, thus to increase ROS content in mitochondria of T-ALL cells.
circulation_biomarker_diagnosis_down	34627193	hsa-mir-485	Glioblastoma	5p/CSF-1 axis, and circCDC45 might be a promising plasmatic biomarker for GBM diagnosis and treatment.
genetics_overexpression_promote	34627051	hsa-mir-10b	Craniosynostosis radial aplasia syndrome	In addition, overexpression of PAI-1 significantly inhibited BGC apoptosis (P < 0.05), and PAI-1 could alleviate BGC apoptosis induced by miR-10b (P < 0.05).
other	34626953	hsa-mir-370	Melanoma	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
other	34626953	hsa-mir-563	Melanoma	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
other	34626953	hsa-mir-770	Melanoma	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
other	34626953	hsa-mir-770	Vitelliform Macular Dystrophy	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
other	34626953	hsa-mir-370	Vitelliform Macular Dystrophy	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
other	34626953	hsa-mir-563	Vitelliform Macular Dystrophy	5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation.
genetics_overexpression_promote	34626803	hsa-mir-375	Nasopharyngeal Carcinoma	Further experiments revealed that up-regulated miR-375 expression led to USP1 down-regulation, and miR-375 overexpression suppressed PI3K/Akt signaling and inhibited NPC cell migration and invasion, but promoted NPC cell apoptosis.
other	34626779	hsa-mir-15a	Diabetic Retinopathy	CONCLUSIONS: LBP attenuates diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
circulation_biomarker_diagnosis_up	34626767	hsa-mir-451a	Hepatitis B	CONCLUSIONS: A plasma panel, including miR
circulation_biomarker_diagnosis_up	34626767	hsa-mir-340	Hepatitis B	ROC curve analysis indicated that both plasma miR-451a and miR
genetics_overexpression_suppress	34626694	hsa-mir-34a	Distal arthrogryposis type 2B	Hsa-miR-34a-5p expression was directly correlated with BUP treatment and LINC00665 overexpression in SH-SY5Y cells.
genetics_GWAS	34626694	hsa-mir-34a	Neurotoxicity Syndromes	CONCLUSIONS: BUP-induced neurotoxicity in human neural cells may be regulated by the epigenetic axis of LINC00665 / hsa-miR-34a-5p.
genetics_GWAS	34626694	hsa-mir-132	Distal arthrogryposis type 2B	Co-regulation of LINC00665 / hsa-miR3p epigenetic axis was further examined on BUP-induced apoptosis in SH-SY5Y cells.
lncRNA target	34626691	hsa-mir-1184	Carcinoma, Renal Cell	"circSNX6 acts as a molecular ""sponge"" to relieve the suppressive effect of microRNA (miR)-1184 on its target gene, glycerophosphocholine phosphodiesterase 1 (GPCPD1), which increases intracellular lysophosphatidic acid (LPA) levels and, ultimately, promotes sunitinib resistance in RCC cells. Our findings demonstrated that the circSNX6/miR-1184/GPCPD1 axis had a critical role in regulation of intracellular LPA levels and sunitinib resistance in RCC; they also provide a novel prognostic indicator and promising therapeutic targets."
other	34626053	hsa-mir-21	Breast Neoplasms	Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors.
other	34626053	hsa-mir-9	Breast Neoplasms	Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors.
other	34626053	hsa-mir-429	Breast Neoplasms	Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors.
other	34626053	hsa-mir-16	Breast Neoplasms	Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors.
other	34625951	hsa-mir-1	Erythema	miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required.
other	34625951	hsa-mir-1	Hyperpigmentation	miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required.
other	34625951	hsa-mir-23b	Erythema	miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required.
other	34625951	hsa-mir-23b	Hyperpigmentation	miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required.
circulation_biomarker_diagnosis_up	34625660	hsa-mir-200c	Severe Acute Respiratory Syndrome	Taken together, our novel results identify that upregulation of miR-200c may increase the susceptibility of individuals with obesity to COVID-19. Considering miRNA are the earliest molecular regulators, the level of circulating miR-200c could be a potential biomarker in the early identification of those at the risk of severe COVID-19.
circulation_biomarker_diagnosis_up	34625660	hsa-mir-200c	Obesity	Taken together, our novel results identify that upregulation of miR-200c may increase the susceptibility of individuals with obesity to COVID-19. Considering miRNA are the earliest molecular regulators, the level of circulating miR-200c could be a potential biomarker in the early identification of those at the risk of severe COVID-19.
genetics_GWAS	34625583	hsa-mir-137	Hepatitis B, Chronic	We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets.
transcription factor target	34624808	hsa-mir-125b	Lung Neoplasms	Xenograft tumor models were constructed to explore the inhibitory effect of CoB1 and the role of miRNA-125b as a suppressor in lung cancer in vivo.
genetics_knock down_suppress	34624276	hsa-mir-212	Triple Negative Breast Neoplasms	AKT3 overexpression reversed the inhibitory effect of miR
circulation_biomarker_diagnosis_up	34624208	hsa-mir-2392	COVID-19	We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19.
lncRNA target	34623609	hsa-mir-20	Norrie disease	CONCLUSIONS: Our findings suggest that TTC28-AS1 attenuates HG-induced damage in HK-2 cells at least partially by targeting the miR-320a/CD2AP axis, highlighting its role as a promising therapeutic approach for DN treatment.
lncRNA target	34623609	hsa-mir-20a	Norrie disease	CONCLUSIONS: Our findings suggest that TTC28-AS1 attenuates HG-induced damage in HK-2 cells at least partially by targeting the miR-320a/CD2AP axis, highlighting its role as a promising therapeutic approach for DN treatment.
exosome	34623606	hsa-mir-29	Spinal Cord Injuries	In all, exosomes derived from TCTN2-modified MSCs could improve functional recovery of SCI in vivo and attenuate LPS-induced neuronal apoptosis, inflammation, and oxidative stress in vitro via miR3p/IGF1R axis, suggesting a novel insight into the development of MSC-exosomes-based therapy for SCI.
genetics_GWAS	34623601	hsa-mir-34a	Colorectal Neoplasms	c-MYC overexpression abrogated EV-derived miR-34a-5p upregulation-induced effects on CRC.
other	34623553	hsa-mir-133b	Pre-Eclampsia	We found that miR-133b was up-regulated, with decreases in JAK2 and p-STAT3/STAT3 in placental tissues of PE patients.
genetics_overexpression_promote	34623217	hsa-mir-122	Carcinoma, Hepatocellular	Cyclin G1 mRNA and protein level were suppressed in HepG2 tumors overexpression miR-122.
lncRNA target	34622398	hsa-mir-5128	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-7093	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-3473f	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-6994	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-574	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-3473	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-7235	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
lncRNA target	34622398	hsa-mir-2128	Megalencephalic leukoencephalopathy with subcortical cysts	PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR
transcription factor target	34621733	hsa-mir-27a	Osteoporosis	Additional experiments showed that miR-27a-5p suppressed autophagy that was activated in OVX rats.
lncRNA target	34621682	hsa-mir-525	Chordoma	5p could be promising therapeutic targets for the treatment of chordoma.
genetics_overexpression_promote	34621503	hsa-mir-34a	Keratosis Follicularis Spinulosa Decalvans, X-Linked	miR-34a can negatively regulate the expression of SATB1, and overexpression of SATB1 reverses the effects of overexpression of miR-34a on the proliferation, migration, and invasion of KFB.
lncRNA target	34621503	hsa-mir-34a	Keloid	OBJECTIVES: To explore the effect and mechanism of miR-34a on the proliferation, migration, and invasion of keloid fibroblasts (KFB). CONCLUSIONS: miR-34a inhibits the proliferation, migration, and invasion of keloid fibroblasts by downregulating the expression of SATB1.
lncRNA target	34621314	hsa-mir-16	Osteosarcoma	CONCLUSION: LINC00662 exerts oncogenic functions in OS by targeting the miR
target gene	34621297	hsa-mir-1287	Carcinoma, Non-Small-Cell Lung	CircDTL acts as an oncogene and exerts its effects via the miR-1287-5p/GPX4 axis in NSCLC
other	34620745	hsa-mir-326	Breast Neoplasms	In summary, this study demonstrated that SP1-activated PCAT6 promoted the malignant behaviors of breast cancer cells by regulating the miR-326/LRRC8E axis.
genetics_knock down_suppress	34620742	hsa-mir-548c	Carcinoma, Hepatocellular	5p, anti-miR-548c-3p or UBE2T overexpression restored the inhibitory effect of circ_0090049 knockdown on HCC cells.
genetics_knock down_suppress	34620742	hsa-mir-605	Carcinoma, Hepatocellular	5p, anti-miR-548c-3p or UBE2T overexpression restored the inhibitory effect of circ_0090049 knockdown on HCC cells.
exosome	34620741	hsa-mir-1253	Carcinoma, Non-Small-Cell Lung	Exosomal circ_0007385 promoted NSCLC cell proliferation and stemness by regulating miR-1253/FAM83A axis.
genetics_knock down_promote	34620126	hsa-mir-216a	Squamous Cell Carcinoma of Head and Neck	Besides, miR-216a-5p or BCL2L2 knockdown partly attenuated the inhibitory influences of circ_0011946 silence or miR-216a-5p overexpression on OSCC cell progression.
other	34619990	hsa-mir-501	Leukoencephalopathies	3p and miR-1959 were the only miRNAs upregulated by OGD, and downregulated by OGD plus CX-4945 and MS-275.
other	34619990	hsa-mir-1959	Leukoencephalopathies	3p and miR-1959 were the only miRNAs upregulated by OGD, and downregulated by OGD plus CX-4945 and MS-275.
genetics_knock down_promote	34619576	hsa-mir-326	Breast Neoplasms	miR-326 inhibition abolished the effects of hsa_circ_0000517 knockdown on the malignant behaviors of breast cancer cells.
lncRNA target	34619168	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	In conclusion, our research identified the regulation of CASC9/miR5p/FOXO3 feedback loop on NSCLC gefitinib resistance, which might help researchers develop potential therapeutic targets for NSCLC.
other	34619102	hsa-mir-26a	Sepsis	We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2).
other	34619102	hsa-mir-26a	Cardiomyopathies	We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2).
other	34618998	hsa-mir-491	Diabetes Mellitus, Type 2	5p expression could improve osteogenic differentiation of jawbone mesenchymal stem cells in patients with type 2 diabetes.
other	34618022	hsa-mir-370	Stomach Neoplasms	3p/EGFR axis.
genetics_overexpression_suppress	34617877	hsa-mir-145	Osteoporosis	5p was overexpressed in OP patients.
circRNA target	34617876	hsa-mir-196a	Leukemia, Myeloid, Acute	Furthermore, circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy.
circRNA target	34617876	hsa-mir-196b	Leukemia, Myeloid, Acute	Furthermore, circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy.
lncRNA target	34617873	hsa-mir-21	Hypoxia	5p expression, inhibits the TLR4/NF-kappaB signaling pathway and suppresses the apoptosis of type II alveolar epithelial cells during hypoxia/reoxygenation injury.
other	34617722	hsa-mir-134	Glioma	Additionally, miR5p levels were significantly reduced and inversely related to ATF5 mRNA under HCMV infection.
other	34617063	hsa-mir-145	Popliteal Artery Aneurysm	MiR-145 were significantly altered (1.7-fold) in those with isolated PA and AAA, whereas miR-326 were altered in those with bilateral (2.3-fold) and isolated PA (1.9-fold).
target gene	34616917	hsa-mir-4766	Colorectal Neoplasms	circ_0000467 promotes the proliferation, metastasis, and angiogenesis in colorectal cancer cells through regulating KLF12 expression by sponging miR-4766-5p.
circulation_biomarker_diagnosis_up	34616615	hsa-mir-21	Breast Neoplasms	CONCLUSION: This study's results showed that plasma exosomal hsa-miR
lncRNA target	34616613	hsa-mir-662	Melanoma	Four groups of ceRNA interaction triplets were finally obtained, which miR-3662 might has potential implication for the treatment of metaststic melanoma patients, and futher experiments confirmed the regulating relationship and phenotype of this assumption. This study provides new targets to regulate metastatic process, predict metastatic potential and indicates that the miR-3662 can be used in the treatment of melanoma.
genetics_overexpression_promote	34616611	hsa-mir-1293	Adenocarcinoma of Lung	Overexpression of PGM5 abrogated the effects of miR-1293 on the malignant phenotypes of LUAD cells.
other	34616498	hsa-mir-361	Carcinoma, Hepatocellular	Overall, BAIAP2-AS1 modulated the miR3p/SOX4 axis to promote the development of HCC.
lncRNA target	34616424	hsa-mir-205	Lung Neoplasms	3p/c-Met axis, which may be a potential target for LC treatment.
other	34616299	hsa-mir-27a	Osteoarthritis	Collectively, XH exhibited protective effects against mechanical stimulation-induced ECM degradation by mediating the GAS5/miR-27a signaling pathway in OA chondrocytes.
other	34616173	hsa-mir-7	Colorectal Neoplasms	3p might be a marker of better outcomes.
other	34616173	hsa-mir-10a	Colorectal Neoplasms	3p might be a marker of better outcomes.
other	34616173	hsa-mir-143	Colorectal Neoplasms	3p might be a marker of better outcomes.
circulation_biomarker_diagnosis_ns	34616172	hsa-mir-21	Osteosarcoma	CONCLUSION: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS.
other	34616170	hsa-mir-23a	Lichen Planus, Oral	MiR-23a-3p was at the low expression in OLP patients and showed close association with the disease severity.
genetics_knock down_promote	34616159	hsa-mir-98	Asthma	CONCLUSION: Our work disclosed that knockdown of circERBB2 suppressed PDGF-BB-caused proliferation, migration and inflammatory response of ASMCs, through regulating miR5p/IGF1R signaling, presented circERBB2 as a promising therapeutic target for asthma.
other	34615552	hsa-mir-183	Follicular Atresia	CONCLUSIONS: We provide a comprehensive perspective of lncRNA regulation of follicular atresia, and demonstrate that NORHA, a novel lncRNA related to follicular atresia, induces GC apoptosis by influencing the activities of the miR96-182 cluster and FoxO1 axis.
genetics_GWAS	34615546	hsa-mir-152	Leukemia	CONCLUSIONS: Taken together, our findings identify two oncogenic regulatory axes in NPM1-mutated AML centered on HOTAIRM1: one involving EGR1 and MDM2 in the nucleus and the other involving the miR3p/ULK3 axis in the cytoplasm.
exosome	34614416	hsa-mir-182	Triple Negative Breast Neoplasms	loaded HUCMSC-exosomes can suppress TNBC invasion, suggesting that exosomes containing miR-3182 could be a reliable therapeutic paradigm in TNBC therapy.
transcription factor target	34614259	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: EZH2 inhibits erastin-induced ferroptosis in TSCC cells via miR-125b-5p/SLC7A11 axis.
lncRNA target	34613933	hsa-mir-1271	Prostatic Neoplasms, Castration-Resistant	In summary, Qi Ling inhibited docetaxel resistance and glycolysis of CRPC possibly via SNHG10/miR5p/TRIM66 pathway.
genetics_knock down_promote	34612783	hsa-mir-545	Squamous Cell Carcinoma of Head and Neck	After performing a series of cell functional experiments, it was found that knockdown of lncRNA CASC9 or LAMC2 resulted in the inhibition of proliferation, colony formation, and migration of OSCC cells, but their negative effects could be partly impaired by the miR
lncRNA target	34612550	hsa-mir-214	Nasopharyngeal Carcinoma	CONCLUSIONS: The present study demonstrated that circ-ITCH suppressed NPC tumorigenesis by upregulating PTEN expression through interacting with miR-214, thus proposing a novel mechanism for NPC inhibition.
lncRNA target	34612153	hsa-mir-654	Carcinoma, Hepatocellular	In conclusion, LINC00460 aggravated cell stemness in HCC via targeting miR
lncRNA target	34612153	hsa-mir-503	Carcinoma, Hepatocellular	In conclusion, LINC00460 aggravated cell stemness in HCC via targeting miR
lncRNA target	34612147	hsa-let-7b	Ovarian Neoplasms	The downregulation of DDX19A reversed the inhibitory effects of MB-let-7b-5p inhibitor on OVCA cells.
lncRNA target	34612146	hsa-mir-146a	Neuralgia	Finally, we demonstrated that CRNDE contributed to the progression of CCI-induced NP via competitive binding to miR-146a-5p to upregulate WNT5A.
genetics_knock down_suppress	34612138	hsa-mir-4306	Carcinoma, Hepatocellular	Finally, miR-4306 downregulation or KDM2A overexpression reversed the prohibitive role of UNC5B-AS1 knockdown in HCC progression.
circulation_biomarker_prognosis_ns	34612058	hsa-mir-19b	Heart Failure, Acute	Conclusions Circulating miR-19b-3p could be a valuable prognostic biomarker for AHF. In addition, a high level of circulating miR-19b-3p might indicate ventricular hypertrophy in AHF subjects.
other	34611549	hsa-mir-92a	Stomach Neoplasms	miR-92a could also be used as a valuable indicator for predicting the prognosis of gastric cancer patients.
other	34611404	hsa-mir-607	Ischemic Stroke	We used bioinformatics approaches to investigate a functional ANGPT1 variant that interferes with miR-607 and explored its association with IS.
lncRNA target	34611295	hsa-mir-210	Fetal Growth Retardation	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
lncRNA target	34611295	hsa-mir-141	Fetal Growth Retardation	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
lncRNA target	34611295	hsa-mir-21	SHORT syndrome	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
lncRNA target	34611295	hsa-mir-210	SHORT syndrome	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
lncRNA target	34611295	hsa-mir-141	SHORT syndrome	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
lncRNA target	34611295	hsa-mir-21	Fetal Growth Retardation	3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies.
circRNA target	34611229	hsa-mir-183	Intracranial Aneurysm	3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients.
circRNA target	34611229	hsa-mir-877	Intracranial Aneurysm	3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients.
exosome	34611143	hsa-mir-370	Stomach Neoplasms	A series of experiments were performed to confirm that circUBE2Q2 regulates GC progression via the circUBE2Q2-miR3p-STAT3 axis and promotes tumor metastasis through exosomal communication.
lncRNA target	34611140	hsa-mir-342	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML.
lncRNA target	34610759	hsa-mir-101	Neonatal Sepsis	3p facilitated the inflammation in NS by targeting DUSP1.
genetics_knock down_promote	34610715	hsa-mir-21	Prostatic Hyperplasia	3p intensified BPH and inflammation level, while knockdown of miR
lncRNA target	34610483	hsa-mir-146b	Cholangiocarcinoma	CONCLUSION: MiR-146b-5p is a cholangiocarcinoma suppressor by inhibiting cell proliferation and promoting cell apoptosis with targeting TRAF6, possibly via modulating p53 translocation to mitochondria.
genetics_overexpression_promote	34610416	hsa-mir-21	Glioma	Conversely, miR-21 overexpression increased cell proliferation and migration; as well as the levels of IRS1, SREBP-1, FASN, and ACC in human PCa cells.
genetics_overexpression_promote	34610416	hsa-mir-21	Prostatic Neoplasms	Conversely, miR-21 overexpression increased cell proliferation and migration; as well as the levels of IRS1, SREBP-1, FASN, and ACC in human PCa cells.
other	34610317	hsa-mir-29c	Lymphopenia	However, after damage, when profound thymocyte depletion occurs, this TAM-Rac1-NOD2-miR29c pathway is attenuated, increasing production of IL-23 and BMP4.
other	34610219	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	5p/PD-L1.
other	34609952	hsa-mir-130	Neuralgia	Up-regulating miR5p repressed LPS-induced inflammation in astrocytes.
genetics_overexpression_suppress	34609952	hsa-mir-130a	Neuralgia	The profiles of MEG3, microRNA (miR)-130a-5p, CXC motif chemokine receptor 12 (CXCL12)/CXC motif chemokine receptor 4 (CXCR4), and the Rac1/NF-kappaB pathway in CCI rats' spinal cord tissues and astrocytes were monitored by reverse transcription-quantitative PCR (RT-qPCR) and western blot (WB). RESULTS: MEG3, CXCL12 and CXCR4 were overexpressed and miR-130a-5p was knocked down in CCI rats and LPS-induced astrocytes.
circulation_biomarker_diagnosis_up	34609722	hsa-mir-624	Congenital Hypothyroidism	5p inhibitor signally enhanced fT4 levels and reduced TSH levels in the plasma of CH rats, and improved CH rat depressive behaviors by targeting SIRT1.
other	34609560	hsa-mir-29b-1	Osteitis Deformans	Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts.
other	34609560	hsa-mir-1246	Osteitis Deformans	Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts.
other	34609560	hsa-mir-181a	Osteitis Deformans	Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts.
other	34609560	hsa-mir-15b	Osteitis Deformans	Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts.
other	34609560	hsa-let-7i	Osteitis Deformans	Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts.
transcription factor target	34609285	hsa-mir-29a	Epilepsy, Temporal Lobe	MiR-29a may be involved in the pathogenesis of TLE through regulation of neuronal apoptosis and neuroinflammation via targeting HMGB1.
other	34609116	hsa-mir-146a	Diabetes Mellitus, Type 2	Expression of cytokine IL-6, IL-10, miR-146a are found to cause diabetic neuropathy.
exosome	34609045	hsa-mir-22	Spinal Cord Injuries	loaded MSCs-EV (EV-miRNA-22) could cooperate with EV to inhibit inflammatory response and nerve function repair after SCI.
other	34609043	hsa-mir-150	Diabetic Cardiomyopathies	5p and downregulate CCND2 to promote cardiomyocyte ferroptosis and DbCM development.
other	34608897	hsa-mir-205	Chronic Rhinosinusitis With Nasal  Polyps	CONCLUSIONS: miRNA 205-5p was increased in CRSwNP compared to controls, and it was especially expressed in CRSwNP patients with higher T2 inflammation (measured by both IL-5 levels and local eosinophilia) and worst clinical presentation.
other	34608841	hsa-mir-589	Hyperglycemia	Mechanistically, circ-UBAP2 sponges miR5p, which is downregulated under hyperglycemic conditions.
genetics_knock down_suppress	34608841	hsa-mir-589	Duane Retraction Syndrome	Taken together, knockdown of circ-UBAP2 relieved HG-induced oxidative stress and dysfunctions of the hRMECs through the miR5p/EGR1 axis, which may offer a promising therapeutic target for DR.
lncRNA target	34608826	hsa-mir-652	Carcinoma, Hepatocellular	3p mimic or inhibitor.
other	34608813	hsa-mir-138	Adenocarcinoma of Lung	5p-HIF1A axis.
lncRNA target	34608568	hsa-mir-23a	Diabetic Nephropathies	Thus, we conclude that miR-23a-3p attenuates the development of DKD through Egr1, suggesting that targeting miR-23a-3p may be a novel therapeutic approach for DKD.
lncRNA target	34608273	hsa-mir-20a	Corneal dystrophy, epithelial basement membrane	Mechanistically, THAP7-AS1 interacted with the 1-50 Amino Acid Region (nuclear localization signal) of CUL4B through its 1-442 nt Sequence, and it promoted interaction between nuclear localization signal (NLS) and importin alpha1, and improved the CUL4B protein entry into the nucleus, repressing miR3p and miR-320a expression by CUL4B-catalyzed H2AK119ub1 and the EZH2-mediated H3K27me3, subsequently activating PI3K/AKT signaling pathway to promote GC progression.
lncRNA target	34608273	hsa-mir-22	Corneal dystrophy, epithelial basement membrane	Mechanistically, THAP7-AS1 interacted with the 1-50 Amino Acid Region (nuclear localization signal) of CUL4B through its 1-442 nt Sequence, and it promoted interaction between nuclear localization signal (NLS) and importin alpha1, and improved the CUL4B protein entry into the nucleus, repressing miR3p and miR-320a expression by CUL4B-catalyzed H2AK119ub1 and the EZH2-mediated H3K27me3, subsequently activating PI3K/AKT signaling pathway to promote GC progression.
other	34608109	hsa-mir-203a	Wilms Tumor	CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample.
other	34608109	hsa-mir-184	Wilms Tumor	CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample.
other	34608109	hsa-mir-194	Wilms Tumor	CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample.
other	34607711	hsa-mir-223	endometrial serous adenocarcinoma	Of these, increased miR-223 expression (>median) was associated with worse OS (p = 0.0496) in an independent dataset (TCGA dataset) comprising of 140 patients with USC (mixed or pure serous). Upregulation of miR-223 may be a prognostic factor in USC.
genetics_GWAS	34607594	hsa-mir-219a-1	Schizophrenia	METHODS: In a case-control study, five SNPs located in 6p21.3-p23.1 including rs2021722 in human leukocyte antigen (HLA) locus and rs107822, rs383711, rs439205 and rs421446 within the upstream of microRNA-219a-1 were genotyped in 454 schizophrenia patients and 445 healthy controls to investigate the possible association between the loci and schizophrenia in a Han Chinese population.
lncRNA target	34607540	hsa-mir-141	Osteosarcoma	3p has been reported to act as a tumor suppressor in osteosarcoma.
circRNA target	34607506	hsa-mir-485	Stomach Neoplasms	5p-GSK3A regulatory network inhibited GC cell proliferation, migration, and invasion, suggesting that circ-HN1 is a potential target for GC therapy.
lncRNA target	34607195	hsa-mir-21	Ischemic Stroke	OBJECTIVE: Long non-coding RNA maternally expressed gene 3 (lnc-MEG3) directly targets microRNA-21 (miR-21) to regulate the vascular microenvironment, and is closely implicated in the pathology of acute ischemic stroke (AIS).
other	34607003	hsa-mir-106a	Lung Neoplasms	We examined regulatory functions of miR-106a-5p in DDP-resistant lung cancer cells.
lncRNA target	34606982	hsa-mir-431	Liver Neoplasms	CONCLUSION: Circ_0078710 promotes the progression of liver cancer by regulating TXNDC5 expression by targeting miR
other	34606735	hsa-mir-1	Myocardial Infarction	The results suggested that miR-1/Myocd induction combined with encapsulation of transduced cells in CS/CO hydrogel increased efficiency of MSCs differentiation into iCMs and could improve heart function in MI model of rats after implantation.
lncRNA target	34606648	hsa-mir-206	Carcinoma, Hepatocellular	Disrupting the interaction between miR-206 and Kras offset the roles of miR-206 in inhibiting immunosuppression and HCC.
lncRNA target	34606644	hsa-mir-146	Gout	based therapy effectively inhibited the formation of NETs in rats with gout.
lncRNA target	34606420	hsa-mir-199a	Endometrial Neoplasms	Additionally, miR-199a-3p inhibitor partly relieved the effects of silencing TTN-AS1 and RUNX1 in OSCC cells due to their targeting relationship.
lncRNA target	34606414	hsa-mir-411	Glioblastoma	miR-411 suppressed the growth, migration, and invasion of glioblastoma cells via modulating signal transducer and activator of transcription 3 (STAT3).
circulation_biomarker_diagnosis_up	34606407	hsa-mir-637	Carotid Stenosis	Kaplan-Meier survival and Cox regression were used to evaluate the potential predictive ability of serum miR-637 levels during follow-up for cerebral ischemia events.
circulation_biomarker_diagnosis_up	34606407	hsa-mir-637	Brain Ischemia	Kaplan-Meier survival and Cox regression were used to evaluate the potential predictive ability of serum miR-637 levels during follow-up for cerebral ischemia events.
lncRNA target	34606403	hsa-mir-214	Pre-Eclampsia	CONCLUSIONS: Up-regulated SNHG7 protects against PE through modulating the miR
lncRNA target	34605515	hsa-mir-141	Prostatic Neoplasms	The microRNA-141 (miR-141), a potential biomarker in prostate cancer, was employed as a model target in the microcapsular biosensor.
lncRNA target	34605350	hsa-mir-196b	Esophageal Squamous Cell Carcinoma	Besides, the suppressor of cytokine signaling 2 (SOCS2) is the target of miR-196b in ESCC.
genetics_knock down_suppress	34605348	hsa-mir-493	Stomach Neoplasms	5p was a target of circPRKDC, and the repressive impact of circPRKDC knockdown on GC development was neutralized by miR
genetics_knock down_promote	34605103	hsa-mir-497	Osteosarcoma	5p overexpression obviously restrained OS proliferation, invasion, and migration.
circulation_biomarker_diagnosis_up	34604414	hsa-mir-21	Stomach Neoplasms	In addition, the miRNA RT-qPCR results showed that, the expression level of miR-21 was significantly higher in gastritis group compared to the healthy group (p< 0.05). CONCLUSION: the present study clearly demonstrated the increasing level of blood miR-21 among the gastritis patients infected by H.
other	34604408	hsa-mir-208a	Cardiovascular Diseases	Also, a significant increase in the expression of miR-208 (HF> arrhythmia> ACS> MI) and a significant decrease in the expression of miR-1 (ACS> arrhythmia> HF> MI) were found in all four groups in cardiovascular patients. CONCLUSION: The results showed increases in oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a in a variety of cardiovascular patients (ACS, MI, arrhythmia, and HF).
other	34604408	hsa-mir-208	Cardiovascular Diseases	Also, a significant increase in the expression of miR-208 (HF> arrhythmia> ACS> MI) and a significant decrease in the expression of miR-1 (ACS> arrhythmia> HF> MI) were found in all four groups in cardiovascular patients. CONCLUSION: The results showed increases in oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a in a variety of cardiovascular patients (ACS, MI, arrhythmia, and HF).
transcription factor target	34604236	hsa-mir-100	gastric adenocarcinoma	In this study, hsa-miR5p was identified as the only dysregulated miRNA in STAD samples through an analysis of three miRNA expression matrices.
target gene	34604211	hsa-mir-98	Carcinoma, Non-Small-Cell Lung	Circular RNA 0006349 Augments Glycolysis and Malignance of Non-small Cell Lung Cancer Cells Through the microRNA-98/MKP1 Axis.
genetics_overexpression_promote	34604205	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	The overexpression of MALAT1 could increase the expression of COX2 by inhibiting the expression of miR-146a, thus affecting the pulmonary function of COPD patients.
genetics_overexpression_suppress	34604093	hsa-mir-1224	Stomach Neoplasms	Moreover, in vitro and in vivo assays revealed that the overexpression of miR-1224 inhibited cell proliferation, migration, and invasion in GC cells.
other	34604087	hsa-mir-21	Primary Central Nervous System Lymphoma	MicroRNA-21 assays also seemed to be more accurate in the diagnosis of PCNSL.
target gene	34604044	hsa-mir-196a	Stomach Neoplasms	CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis.
circulation_biomarker_diagnosis_up	34603911	hsa-mir-22	Adenocarcinoma of Lung	We further validated that LINC00968 localized in cytoplasm and acted as an upstream regulator of microRNA miR
other	34603671	hsa-mir-155	Lung Neoplasms	This method can simultaneously quantify miR-155 and miR-21 in living cells and in lung cancer tissues, and it can distinguish the expression of miRNAs between non-small cell lung cancer patients and healthy persons.
other	34603671	hsa-mir-21	Lung Neoplasms	This method can simultaneously quantify miR-155 and miR-21 in living cells and in lung cancer tissues, and it can distinguish the expression of miRNAs between non-small cell lung cancer patients and healthy persons.
lncRNA target	34603558	hsa-mir-1225	Glioma	CONCLUSION: Our findings revealed the tumor-promotive roles of LINC00355 in the progression of glioma, indicating that LINC00355 exhibited ceRNA functions via modulating miR-1225/FNDC3B axis.
other	34603557	hsa-mir-375	Thyroid Cancer, Papillary	METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues.
other	34603557	hsa-mir-183	Thyroid Cancer, Papillary	METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues.
other	34603557	hsa-mir-96	Thyroid Cancer, Papillary	METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues.
other	34603557	hsa-mir-182	Thyroid Cancer, Papillary	METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues.
lncRNA target	34603528	hsa-mir-485	Arthritis, Rheumatoid	RAFLSs were transfected with short interfering (si)-X-inactive specific transcript (XIST), microRNA (miR)-485 mimic, miR-485 inhibitor or si-PSMB8 or combination.
circulation_biomarker_diagnosis_ns	34603466	hsa-mir-127	Respiratory Distress Syndrome	It suggests that the serum miR-127 level is an important indicator for evaluating the severity of ARDS patients.
transcription factor target	34603449	hsa-mir-491	Colonic Neoplasms	According to these results, CS-Rh2-TPP is able to upregulate miR-491 in CCCs, thus suppressing the metastasis and growth of CC.
transcription factor target	34603448	hsa-mir-559	Colorectal Neoplasms	miR-559 inhibited, while CBS accelerated, CRC proliferation. DiAcSpm accelerated CRC proliferation by regulating the miR-559/CBS axis.
other	34603374	hsa-mir-346	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-653	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-539	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-346	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-653	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-376b	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-539	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-497	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-497	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-4262	Cardiomyopathy, Right Ventricular Dilated	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-4262	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603374	hsa-mir-376b	Tricuspid Valve Insufficiency	5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks.
other	34603024	hsa-mir-146a	Lung Neoplasms	Conclusion: Our research demonstrated the potential of using ANRIL rs1333049 (G > C) and miR-146A rs2910164 (C > G) as biomarkers to support the prediction of a better prognosis for lung cancer patients receiving platinum-based chemotherapy.
other	34602559	hsa-mir-122a	Chemical and Drug Induced Liver Injury	In order to reduce the Ad vector-induced hepatotoxicity, we previously developed an Ad vector containing the sequences perfectly complementary to a liver-specific microRNA (miRNA), miR-122a, in the 3'-untranslated region (UTR) of the E4 gene.
other	34602528	hsa-mir-146	Lung Diseases	Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure.
other	34602528	hsa-mir-146a	Lung Diseases	Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure.
other	34602528	hsa-mir-146b	Lung Diseases	Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure.
lncRNA target	34602449	hsa-mir-494	Premature Birth	Understanding the role of miR3p in endometrial receptivity is of great significance for exploring new targets for the diagnosis and treatment of early pregnancy failure, and improving the success rates of artificial reproduction.
lncRNA target	34602415	hsa-mir-26a	Carcinoma, Hepatocellular	The obtained data introduce an evidence for the suppressive impact of miRNA-26a on liver tumor formation and its possible manipulation as a therapeutic design for HCC.
circulation_biomarker_diagnosis_ns	34602388	hsa-mir-126	Diabetic Nephropathies	This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels. The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect.
circulation_biomarker_diagnosis_ns	34602388	hsa-mir-342	Diabetic Nephropathies	This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels. The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect.
lncRNA target	34602057	hsa-mir-146b	Inflammation	CONCLUSIONS: MINCR may induce alveolar epithelial cell injury and inflammation and aggravate the progression of ALI/ARDS through miR-146b-5p and TRAF6/NF-kappaB pathways, which would provide a promising target for the treatment of ALI/ARDS.
lncRNA target	34602057	hsa-mir-146b	Respiratory Distress Syndrome	CONCLUSIONS: MINCR may induce alveolar epithelial cell injury and inflammation and aggravate the progression of ALI/ARDS through miR-146b-5p and TRAF6/NF-kappaB pathways, which would provide a promising target for the treatment of ALI/ARDS.
other	34601609	hsa-mir-130b	Kidney Failure, Chronic	CONCLUSIONS: Adipose miR-130b and miR5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients.
other	34601609	hsa-mir-17	Kidney Failure, Chronic	CONCLUSIONS: Adipose miR-130b and miR5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients.
lncRNA target	34601499	hsa-mir-539	Colorectal Neoplasms	Our data reveal the novel role of miR-539 in regulating ferroptosis in CRC via activation of the SAPK/JNK axis, providing new insight into the mechanism of abnormal proliferation in CRC and a novel potential therapeutic target for advanced CRC.
genetics_overexpression_promote	34601384	hsa-mir-146a	Colorectal Neoplasms	The present study aimed to investigate how exogenous induction of miR-146a affects CXCR4 gene and protein expression and also proliferation, apoptosis and migration of CRC cells. Therefore, our results are indicating that overexpression of miR-146a, despite downregulation of oncogenic CXCR4, may not lead to a universal tumor suppressive effect in all CRC cells, and this is possibly due to differences in miR-146a effects on signaling pathways in each cell type.
exosome	34601333	hsa-mir-27a	Carcinoma, Hepatocellular	CONCLUSION: M2 macrophages-derived exosomal miR-27a-3p promotes cancer stemness of HCC via downregulating TXNIP.
other	34600545	hsa-mir-10b	Keloid	Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid.
other	34600545	hsa-mir-372	Keloid	Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid.
other	34600545	hsa-mir-20	Keloid	Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid.
genetics_knock down_promote	34600394	hsa-mir-150	Glomerulonephritis, IGA	The results showed that in the GH-IgAN group, the miRNA-150 expression was positively correlated with systolic blood pressure (beta=2.36, 95% CI 1.11-3.61, P=0.0016), diastolic blood pressure (beta=1.02, 95% CI 0.22-1.82, P=0.0224), uric acid (beta=7.43, 95% CI 1.81-13.04, P=0.0184), leukocyte count (beta=0.22, 95% CI 0.09-0.35, P=0039), neutrophil count (beta=0.19, 95% CI 0.06-0.32, P=0.0096), cholesterol (beta=0.09, 95% CI 0.02-0.16, P=0.0207) and triglyceride level (beta=0.16, 95% CI 0.10-0.22, P<0.000).
lncRNA target	34600339	hsa-mir-194	Brain Injuries	Our study suggested MSC-EXs loaded with miR-194 attenuated OGD/R-induced injury via targeting Bach1, providing a new therapeutic strategy for cerebral injuries.
other	34600339	hsa-mir-194	Vascular Diseases	The neuroprotective function of miR-194 on neurovascular endothelial cell injury is perceived as a novel method for clinical therapy.
circulation_biomarker_diagnosis_ns	34599867	hsa-mir-1	Low Tension Glaucoma	The MALAT1 level in serum of NTG patients carrying GGGT haplotype was significantly decreased compared with NTG patients carrying other haplotypes, along with elevated miR-1 expression and diminished IL-6 expression. This study presented evidence for a regulatory network containing MALAT1, miR-1 and IL-6, and further demonstrated the effect of MALAT1 haplotype on the risk and severity of NTG.
exosome	34599680	hsa-mir-1915	Colorectal Neoplasms	CONCLUSION: Exosomal delivery of miR
genetics_knock down_promote	34599436	hsa-mir-744	Carcinoma, Non-Small-Cell Lung	Gain- and loss-of-function experiment was performed by transfection with miR-744 agomir or antagomir in NSCLC cell lines.
lncRNA target	34599154	hsa-mir-138	Acute Lung Injury	5p promotes NLRP3-triggered inflammatory response via lncRNA NLRP3/miR
other	34599150	hsa-mir-361	Carcinoma, Hepatocellular	Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the mRNA levels of circ_0011385, miR3p, and STC2 in 96 pairs of HCC tissues (tumor tissues and adjacent normal tissues), HCC cell lines, and L02 (human normal liver cell line) cells.
epigenetics	34598837	hsa-mir-1908	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-223	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-503	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-34a	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-7-2	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-143	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-146a	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-16	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-200b	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
epigenetics	34598837	hsa-mir-126	Large Artery  Atherosclerosis	Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly.
genetics_overexpression_promote	34598688	hsa-mir-17	Squamous Cell Carcinoma of Head and Neck	5p blocked HNSCC cells in G2/M phase, whereas its overexpression propelled cell cycle progression.
lncRNA target	34598322	hsa-mir-29c	Carcinoma, Renal Cell	Moreover, we concluded that H19-miR-29c-3p-COL1A1 axis might promote the polarization of M2 macrophages and inhibit M1 macrophage activation through Wnt signaling pathway, collaborating to promote PRCC tumorigenesis and lead to poor overall survival of PRCC patients.
lncRNA target	34597997	hsa-mir-342	Osteosarcoma	Furthermore, inhibiting miR
transcription factor target	34596809	hsa-mir-539	Colonic Neoplasms	CONCLUSION: Re-WSP1 suppresses colon cancer cell growth via the miR-539/beta-catenin axis.
genetics_GWAS	34596730	hsa-mir-548b	Lung Neoplasms	A novel regQTL-SNP, rs3768617, might affect lung cancer risk by modulating the expression patterns of miRNA-548b-3p and LAMC1.
genetics_GWAS	34596578	hsa-mir-146a	Diabetes Mellitus, Type 2	We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence.
genetics_GWAS	34596578	hsa-mir-196a	Diabetes Mellitus, Type 2	We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence.
genetics_GWAS	34596578	hsa-mir-499	Diabetes Mellitus, Type 2	We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence.
other	34596365	hsa-mir-574	Lung Neoplasms	Hence, we describe a novel function of miR5p unique to adenocarcinoma.
lncRNA target	34596354	hsa-let-7b	Osteoporosis	OPG, miR5p, and let-7b-5p in ASC-EVs inhibit osteoclast differentiation and reduce gene expression related to bone resorption, suggesting that ASC-EVs are highly promising as cell-free therapeutic agents for osteoporosis treatment.
lncRNA target	34596354	hsa-mir-21	Osteoporosis	OPG, miR5p, and let-7b-5p in ASC-EVs inhibit osteoclast differentiation and reduce gene expression related to bone resorption, suggesting that ASC-EVs are highly promising as cell-free therapeutic agents for osteoporosis treatment.
transcription factor target	34596215	hsa-mir-20b	Colorectal Neoplasms	In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC cells. These findings showed that JNK/ERK signaling pathway is involved in miR-20b-5p/SDC2 axis-mediated 5-FU resistance in SW480/5-FU cells, indicating that the miR-20b-5p/SDC2 axis is a potential target for reversing 5-FU resistance in CRC.
circulation_biomarker_diagnosis_up	34596006	hsa-mir-3200	Carcinoma, Hepatocellular	phenylindole; DARS-AS1: DARS1 antisense RNA 1; DEPC: diethyl pyrocarbonate; DMEM-F12: Dulbecco's minimal essential medium/Ham's-F12; EMT: epithelial-mesenchymal transition; ERK: extracellular signal-regulated kinase; FAK: focal adhesion kinase; FBS: fetal bovine serum; GAPDH: glyceraldehyde
lncRNA target	34595994	hsa-mir-488	Ovarian Neoplasms	In summary, LncRNA CASC9 played a regulative role in ovarian carcinoma by cyclinG1/TP53/MMP7 signaling via binding to miR3p in vivo and in vitro.
genetics_knock down_suppress	34595849	hsa-mir-501	Kidney Neoplasms	3p/WTAP/CDK2 axis and is inhibited by the overexpression of miR
target gene	34595351	hsa-mir-29c	Fibrosis, Renal	CONCLUSION: Dysregulation of miR-29c-3p and Fer plays a role in RF.
lncRNA target	34595348	hsa-mir-23b	Nance-Horan syndrome	In conclusion, lncRNA NEAT1 as a ceRNA can adsorb miR-23b-3p and promote the expression of CYP1A2, which then inhibits the osteogenic differentiation of hBMSCs and promotes the progress of SNFH.
other	34595235	hsa-mir-933	Heart Failure	The findings suggested a potential hsa-miR-933/RELB/CCL21 regulatory axis correlated with HF and neurological disorders (or cognitive impairment), according to PPI networks.
lncRNA target	34595165	hsa-mir-1307	Urinary Bladder Neoplasms	Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC.
lncRNA target	34594577	hsa-mir-485	Alzheimer Disease	5p ameliorates AD progression by targeting PACS1.
target gene	34594415	hsa-mir-122	Acute Lung Injury	miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN.
circRNA target	34594413	hsa-mir-582	Carcinoma, Hepatocellular	3p axis may represent a potential target for HCC diagnosis and treatment.
target gene	34594410	hsa-mir-345	Pancreatic Neoplasms	Silencing of long non-coding RNA SNHG15 suppresses proliferation, migration and invasion of pancreatic cancer cells by regulating the microRNA-345-5p/RAB27B axis.
other	34594378	hsa-mir-642a	Carcinoma, Hepatocellular	CONCLUSION: Taken together, it is the first time we discovered the interaction of NR2F1-AS1 with miR-642a in modulating HCC cell invasion and migration.
lncRNA target	34594374	hsa-mir-490	Stomach Neoplasms	DTL was the target of and inversely associated with miR
other	34594360	hsa-mir-126	Hypertension	The expression of miR3p and 182-5p was significantly higher in known hypertensives relative to both screen-detected hypertensives and normotensives, and also in screen-detected hypertensives vs normotensives.
other	34594360	hsa-mir-182	Hypertension	The expression of miR3p and 182-5p was significantly higher in known hypertensives relative to both screen-detected hypertensives and normotensives, and also in screen-detected hypertensives vs normotensives.
other	34593980	hsa-let-7b	Neonatal Encephalopathy	This finding of the Hippo-YAP association with let-7b needs validation in larger cohorts to further our knowledge on let-7b-5p as a biomarker for neonatal encephalopathy.
genetics_knock down_promote	34593318	hsa-mir-28	Breast Neoplasms	CONCLUSION: Circ-RPPH1 knockdown retarded cell malignant phenotypes and glycolysis via miR
lncRNA target	34592963	hsa-mir-1226	Periodontitis	BACKGROUND: miR-1226 has been reported to be dysregulated in periodontitis, implying its potential functional role, which needs to be validated.
genetics_overexpression_suppress	34592939	hsa-mir-105	Colorectal Neoplasms	It was verified through rescue assays that RAB22A overexpression or miR
exosome	34592902	hsa-mir-4488	Vitreoretinopathy, Proliferative	However, the roles of exosomal miR-4488 and miR-1273 g-5p in PVR progression have not been demonstrated.
exosome	34592902	hsa-mir-1273g	Vitreoretinopathy, Proliferative	However, the roles of exosomal miR-4488 and miR-1273 g-5p in PVR progression have not been demonstrated.
lncRNA target	34592894	hsa-mir-497	Fractures, Bone	It was concluded that LncRNA PVT1 silencing may enhance fracture healing via mediating miR
circulation_biomarker_diagnosis_up	34592889	hsa-mir-15a	Osteosarcoma	miR-15a was identified as a major cargo of serum-derived exosomes, and exosomes conveying miR-15a were internalized by OS cells.
genetics_overexpression_promote	34592882	hsa-mir-128	Sepsis	All in all, OIP5-AS1 overexpression enhanced sepsis-induced ALI by modulating the miR
genetics_overexpression_promote	34592882	hsa-mir-128	Lung Injury	All in all, OIP5-AS1 overexpression enhanced sepsis-induced ALI by modulating the miR
transcription factor target	34592879	hsa-mir-379	Carcinoma, Non-Small-Cell Lung	We demonstrated that HC0074027 promotes NSCLC chemoresistance via sequestering miR
genetics_GWAS	34592792	hsa-mir-195	Atherosclerosis	In summary, our results revealed a novel mechanism that transcriptional and epigenetic regulation of miR3p inhibits macrophage inflammation through targeting IL-31, which provides a candidate diagnostic marker and novel therapeutic target in cardiovascular diseases induced by Hcy.
circRNA target	34592064	hsa-mir-16	Osteosarcoma	5p via Starbase.
lncRNA target	34591706	hsa-mir-4677	Urinary Bladder Neoplasms	CONCLUSIONS: LINC00265 promotes the viability, proliferation, and migration of BCa cells by binding with miR3p to upregulate FGF6 expression.
genetics_overexpression_promote	34591390	hsa-mir-34a	Laryngeal Neoplasms	Moreover, miR-34a overexpression reduced the enchaining effects of prominin 1 on LC cell proliferation.
genetics_overexpression_promote	34591388	hsa-mir-24	Lymphoma, Mantle-Cell	3p overexpression led to an increased apoptotic rate of MCL cells.
other	34591387	hsa-mir-505	Stomach Neoplasms	Therefore, MAFG-AS1 might upregulate PLK1 by sponging miR-505 to promote GA cell proliferation.
lncRNA target	34591354	hsa-mir-182	Squamous Cell Carcinoma of Head and Neck	5p and its predicted target kinectin 1 (KTN1) in oral squamous cell carcinoma (OSCC).
genetics_knock down_suppress	34590382	hsa-mir-30	Neurotoxicity Syndromes	3p inhibition on Sev-induced neurotoxicity could be offset by ULK1 knockdown or further intensified by Dex treatment.
lncRNA target	34590156	hsa-mir-9	Prostatic Neoplasms	After PC3 cells were transfected with miR9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathwayrelated proteins [PDK1, phosphorylated (p)AKT and pmTOR] were increased or decreased, respectively. The present study found that curcumol regulates the PDK1/AKT/mTOR signaling pathway via miR9 and affects the development of prostate cancer.
exosome	34589894	hsa-mir-146a	Alzheimer Disease	The present study indicates that following an EE, exosomal miR-146a derived from the CP cells is a key factor in ameliorating astrocytic inflammation, leading to synaptogenesis and correction of cognitive impairment.
genetics_knock down_promote	34589612	hsa-mir-513b	Retinoblastoma	In addition, miR-513b-5p mimics neutralized the effects of TRIB1 overexpression on the proliferation and apoptosis of Weri-RB1 cells.
lncRNA target	34589581	hsa-mir-30	Colorectal Neoplasms	Rescue experiments demonstrated that FGD5-AS1 promotes glycolysis through modulating the miR3p-HK2 axis, leading to 5-Fu resistance of CRC cancer cells.
lncRNA target	34589581	hsa-mir-30	Colonic Neoplasms	Rescue experiments demonstrated that FGD5-AS1 promotes glycolysis through modulating the miR3p-HK2 axis, leading to 5-Fu resistance of CRC cancer cells.
transcription factor target	34589519	hsa-mir-378a	Asthma	Conclusion: Our findings suggest that miR-378a-3p/GRB2 pathway regulates the polarization of alveolar macrophages which acts as a potential therapeutic target for airway inflammation and remodeling in asthma.
circulation_biomarker_diagnosis_up	34589435	hsa-mir-1228	Pancreatic Carcinoma	The diagnostic value of plasma-derived Exo-miR-19b normalized using miR-1228 is superior to that of serum CA19-9 in differentiating patients with Pca from healthy volunteers.
other	34589382	hsa-mir-1287	Ischemic Stroke	Previous studies have indicated that miR5p was downregulated in patients with ischemic stroke.
other	34589284	hsa-mir-7	Diabetes Mellitus, Type 1	MicroRNA (miR)-7 has been demonstrated to be necessary and sufficient to repress the autophagy pathway in cell models of the disease, but the origin of its low levels in DM1 was unknown.
genetics_knock down_promote	34589278	hsa-mir-497	Stomach Neoplasms	Furthermore, overexpression of miR-497 inhibited the metastasis of GC cells in vivo, which could be counteracted by CDC42 restoration.
other	34589277	hsa-mir-218	Choroidal Neovascularization	In vivo, intravitreal injection of miR-218 reduced retinal EC proliferation accompanied by MYC repression, attenuated pathological choroidal neovascularization, and rescued retinal EC hyper-sprouting induced by Notch blockade.
transcription factor target	34589277	hsa-mir-218	Neovascularization, Pathologic	In summary, miR-218 mediates the effect of Notch activation of EC quiescence via MYC and is a potential treatment for angiogenesis-related diseases.
transcription factor target	34589273	hsa-mir-21	Intestinal Diseases	The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury.
transcription factor target	34589273	hsa-mir-21	Sepsis	The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury.
genetics_overexpression_promote	34589270	hsa-mir-29a	Ovarian Neoplasms	Overexpressed miR-29a-3p was detected in OC, and miR-29a-3p promoted OC cell proliferation and immune escape.
other	34589151	hsa-mir-299	Uterine Cervical Neoplasms	Long non-coding RNA UCA1 enhances cervical cancer cell proliferation and invasion by regulating microRNA-299-3p expression.
genetics_knock down_promote	34589042	hsa-mir-340	Glioblastoma	The cell proliferation assay showed that circNF1 siRNA silencing and miR-340 overexpression decreased the proliferation of GBM cells.
genetics_knock down_promote	34589042	hsa-mir-340a	Glioblastoma	The cell proliferation assay showed that circNF1 siRNA silencing and miR-340 overexpression decreased the proliferation of GBM cells.
genetics_overexpression_suppress	34588984	hsa-mir-548b	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	miR-548b-3p was overexpressed in circ_0058493-downregulated CML cells.
transcription factor target	34588978	hsa-mir-9	Dermatitis, Atopic	MiR-9, negatively regulated by HDAC6, suppressed AD by directly regulating the expression of sirtuin 1 (SIRT1).
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-423	Osteoarthritis	Serum expression of miR
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-155	Osteoarthritis	Serum expression of miR
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-155	Osteoporotic Fractures	Serum expression of miR
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-423	Osteoporotic Fractures	Serum expression of miR
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-365	Osteoporotic Fractures	Serum expression of miR
circulation_biomarker_diagnosis_ns	34588560	hsa-mir-365	Osteoarthritis	Serum expression of miR
epigenetics	34588546	hsa-mir-200c	Colorectal Neoplasms	Here, we investigated 5mC and m6A in hsa-miR-200c-5p extracted from colorectal cancer cells and determined their methylation sites and rates; the data were comparable to those determined by mass spectrometry.
genetics_knock down_promote	34588094	hsa-mir-506	Carcinoma, Non-Small-Cell Lung	Our study confirmed the exact roles of LAMTOR5-AS1 for the first time and revealed that LAMTOR5-AS1 knockdown disrupts the malignancy of NSCLC by targeting the miR
transcription factor target	34587879	hsa-mir-218	Cardiomyopathies	5p plays an important role in myocardial fibrosis after MI by targeting CX43.
transcription factor target	34587879	hsa-mir-218	Myocardial Infarction	5p plays an important role in myocardial fibrosis after MI by targeting CX43.
genetics_knock down_suppress	34587874	hsa-mir-378a	Squamous Cell Carcinoma of Head and Neck	In conclusion, our data suggested that YEATS2 expression was regulated by miR-378a-5p and YEATS2 knockdown inhibited proliferation and metastasis while induced apoptosis in HNSCC cells.
genetics_overexpression_promote	34587717	hsa-mir-29a	Squamous Cell Carcinoma of Head and Neck	Overexpression of miR-29a-3p resulted in suppressed cell viability, proliferation, migration ability and increased cell apoptosis, while this expression pattern can be partially counteracted by ADAM12 overexpression in OSCC cells.
lncRNA target	34587435	hsa-mir-149	Stomach Neoplasms	5p might be a target of LINC01420 and mediate the effects of LINC01420 on GCa cell proliferation and migration and invasion.
other	34587228	hsa-mir-1246	Leukemia, Myeloid, Acute	Proof-of-concept studies using a murine model and patient-derived xenografts demonstrate the feasibility of developing miR-1246, as a potential minimally invasive AML biomarker.
genetics_knock down_promote	34587164	hsa-mir-20a	Leukemia, Myeloid, Acute	Furthermore, PPP6C knockdown imitated, while overexpression reversed the effects of miR-20a-5p overexpression on AML cell proliferation, cell cycle G1/S transition and apoptosis.
genetics_overexpression_promote	34587154	hsa-mir-195	Prostatic Neoplasms	Databases identified several miRNAs capable of binding COMT and of these, miR-195 was observed to be increased in prostate cancer according to TCGA. Real-time PCR validated upregulation of miR-195 in clinical prostate cancer specimens as well as DuPro and DU145 and interestingly, luciferase reporter showed miR-195 capable of binding COMT and overexpressing miR-195 could reduce COMT in cells.
lncRNA target	34586953	hsa-mir-650	Stomach Neoplasms	These findings indicate that targeting DICER-AS1 and miR-650 could be a novel treatment for gastric cancer.
circulation_biomarker_diagnosis_up	34586739	hsa-mir-26b	Pancreatitis, Chronic	"3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR"
circulation_biomarker_diagnosis_up	34586739	hsa-mir-26b	Carcinoma, Pancreatic Ductal	"3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR"
circulation_biomarker_diagnosis_up	34586739	hsa-mir-95	Pancreatitis, Chronic	"3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR"
circulation_biomarker_prognosis_ns	34586739	hsa-mir-340	Pancreatitis, Chronic	3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR
circulation_biomarker_prognosis_ns	34586739	hsa-mir-340	Carcinoma, Pancreatic Ductal	3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR
circulation_biomarker_prognosis_ns	34586739	hsa-mir-335	Carcinoma, Pancreatic Ductal	3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR
circulation_biomarker_prognosis_ns	34586739	hsa-mir-335	Pancreatitis, Chronic	3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR
circulation_biomarker_diagnosis_up	34586739	hsa-mir-95	Carcinoma, Pancreatic Ductal	"3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR"
lncRNA target	34586738	hsa-mir-145	esophagus adenocarcinoma	5p and inhibiting SPOP-dependent ubiquitination and degradation of PD-L1, thus, presenting new target for EAC adjunct therapy.
exosome	34586722	hsa-mir-19b	Adenocarcinoma of Lung	RBMX bound to miR-19b-3p to facilitate the packaging of miR-19b-3p into LUAD cell-derived exosomes.
genetics_overexpression_promote	34586647	hsa-mir-138	Carcinoma, Renal Cell	5p could hinder KIRC proliferation and invasion, while artificial overexpression of SIN3A led to reversed trends.
lncRNA target	34586488	hsa-mir-519d	Carcinoma, Non-Small-Cell Lung	The restoration of miR-519d-3p in these NSCLC cells inhibited cell proliferation, invasion and migration; enhanced cell sensitivity to gefitinib.
genetics_overexpression_promote	34585634	hsa-mir-195	Nasopharyngeal Carcinoma	3p, and CDK1 overexpression counteracted the effects of miR
lncRNA target	34585626	hsa-mir-132	Alzheimer Disease	3p reduces apoptosis of SH-SY5Y cells and alleviates impairments of learning and memory abilities in AD rats by modulating the HNRNPU/BACE1 axis.
lncRNA target	34585441	hsa-mir-449c	Ischemic Stroke	Collectively, SNHG8 inhibits microglia activation and BBB permeability via the miR-449c-5p/SIRT1/FoxO1 pathway, thus eliciting protective effects on ischemic brain injury.
exosome	34585365	hsa-mir-186	Fibrosis, Renal	Moreover, exosomal miR
lncRNA target	34584571	hsa-mir-125b	Carcinoma, Hepatocellular	Taken together, the findings from the present study demonstrated that CYTOR could promote cell proliferation and tumor growth by sponging miR-125b and upregulating SEMA4C, which suggested that CYTOR may act as a potential therapeutic target in HCC.
other	34584569	hsa-mir-589	Pancreatic Neoplasms	A novel long non-coding RNA TTN-AS1/microRNA-589-5p/FOXP1 positive feedback loop increases the proliferation, migration and invasion of pancreatic cancer cell lines.
other	34584554	hsa-mir-96	Infertility	Therefore, miR5p may serve as a potential biomarker for male infertility.
other	34584554	hsa-mir-96	Infertility, Male	Therefore, miR5p may serve as a potential biomarker for male infertility.
transcription factor target	34584553	hsa-mir-15b	Aortic Aneurysm, Abdominal	The present study aimed to explain the roles of miR-15b/ACSS2 in AAA by exploring their effects on the proliferation and apoptosis of aortic VSMCs. The present study provided preliminary evidence indicating that the miR-15b-5p/ACSS2/PTGS2 axis may be a potential target for the treatment of AAA.
target gene	34584550	hsa-mir-28	Prostatic Neoplasms	miR-28-3p inhibits prostate cancer cell proliferation, migration and invasion, and promotes apoptosis by targeting ARF6.
target gene	34584547	hsa-mir-875	Urinary Bladder Neoplasms	lncRNA LOC339524 inhibits the proliferation of bladder cancer cells by targeting the miR-875-5p/COPS7A signaling axis.
lncRNA target	34584454	hsa-mir-1306	Osteosarcoma	5p remarkably inhibits the malignant behavior of OS cells.
genetics_overexpression_promote	34583851	hsa-mir-614	Sleep Apnea, Obstructive	The suppression of silencing RGMB-AS1 on OSA cell progression was rescued by ANKRD1 overexpression or miR
lncRNA target	34583641	hsa-mir-29b-1	Multiple Sclerosis	qPCR showed that MAPK6 and MMP19, targets of miR-301b-3p, were upregulated in MS and reversed by Enr.
other	34583641	hsa-mir-29	Multiple Sclerosis	RESULTS: MS, Enr, RS, and sex altered hypothalamic miRNAs, including several previously reported in MS literature: miRs-29, - 124, - 132, - 144, - 504.
epigenetics	34583641	hsa-mir-219a	Multiple Sclerosis	Additionally, miR-219a was hypermethylated in MS coinciding with decreased miR-219a expression.
genetics_knock down_promote	34583623	hsa-mir-519d	Retinoblastoma	CONCLUSION: PROX1-AS1 knockdown upregulates miR-519d-3p to promote chemosensitivity of RB cells via targeting SOX2.
lncRNA target	34583619	hsa-mir-136	Adrenocorticotropic hormone deficiency	CONCLUSION: NORAD suppressed miR
lncRNA target	34583064	hsa-mir-708	Carcinoma, Hepatocellular	5p, as a HBV-related miRNA, was a potential target of LINC01232, and was negatively correlated with LINC01232 in HCC.
genetics_overexpression_promote	34582975	hsa-mir-127	Glioblastoma	3p overexpression alleviated this effect.
transcription factor target	34582743	hsa-mir-1306	Diabetes Mellitus	In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR
transcription factor target	34582743	hsa-mir-1306	Testicular Diseases	In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR
transcription factor target	34582697	hsa-mir-221	Prostatic Neoplasms	CELSR3 seems to play a pivotal role in MPCa by affecting the focal adhesion pathway and/or being targeted by miRNA
lncRNA target	34582667	hsa-mir-27a	Carcinoma, Hepatocellular	CONCLUSION: The present data demonstrated targeting miR-27a enhances the anti-tumor effect of SOR in HCC cell lines considering as one of the promising therapeutic targets for advanced HCC management.
other	34582645	hsa-mir-199a	Carcinoma, Hepatocellular	We aimed at investigating microRNA-199 as a potential therapeutic tool for HCC both in vitro and in an experimental model. Histopathological examination of liver specimens after miRNA 199a treatment showed regression of Hepatocellular carcinoma with restoration of normal architecture.
transcription factor target	34582541	hsa-mir-20a	Lung Neoplasms	These findings provide a new and promising anticancer strategy via the use of Au-RGD-miR-320a nanoparticles, and identify miR-320a/Sp1 as a potential target for future systemic therapy against lung cancer.
lncRNA target	34582362	hsa-mir-20	Cardiomyopathies	MiR-320 mimics accelerated cardiac hypertrophy and cardiac fibrosis via the IL6/STAT3/PTEN axis.
lncRNA target	34582362	hsa-mir-20	Cardiomegaly	MiR-320 mimics accelerated cardiac hypertrophy and cardiac fibrosis via the IL6/STAT3/PTEN axis.
circulation_biomarker_diagnosis_up	34582317	hsa-mir-23b	Pulmonary Arterial Hypertension	CONCLUSION: The expression level of miR-23b was remarkably up-regulated in serum of CHD patients and H9C2 cells in vitro, while the expression of GATA6 and IGF-1 was significantly decreased.
exosome	34581942	hsa-mir-125a	Wounds and Injuries	MiR-125a-3p from the HADSCs-exosome promoted the wound healing and angiogenesis, and these effects were achieved through regulating PTEN.
other	34581937	hsa-mir-708	Cranial Nerve Injuries	After sciatic nerve injury, miR708-5p was highly expressed in neuregulin-treated Schwann cells, whereas it was downregulated during postnatal development.
other	34581937	hsa-mir-708	Sciatic Neuropathy	After sciatic nerve injury, miR708-5p was highly expressed in neuregulin-treated Schwann cells, whereas it was downregulated during postnatal development.
other	34581616	hsa-mir-140	Hyperostosis	RESULTS: Pretreatment of MSCs with miR-140 significantly increased the expression of cartilage-specific genes (COL2A1, SOX9, and ACAN) with reduced hypertrophic chondrocyte (COL10A1) marker expression and better safranin-O staining than the control.
lncRNA target	34580912	hsa-mir-21	Brain Ischemia	Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model.
lncRNA target	34580912	hsa-mir-146a	Brain Ischemia	Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model.
other	34580516	hsa-mir-16	Pre-Eclampsia	CONCLUSIONS: Deregulated micro ribonucleic acid-16 along with differentially expressed apoptotic genes, survivin and tumour protein p53 might result in altered apoptosis implicated in the pathogenesis of preeclampsia.
lncRNA target	34580402	hsa-mir-16	Sarcopenia	Therefore, miR5p can be a novel therapeutic target in the context of cardiac repair disturbances in sarcopenia-cachexia.
lncRNA target	34579548	hsa-mir-125b	Pancreatic Carcinoma	Conclusion: M2-targeted HA-PEI/PEG nanoparticles with miR-125b can transfect tumor-associated macrophages in pancreatic tissues and may have implications for PDAC immunotherapy.
circulation_biomarker_prognosis_up	34577789	hsa-mir-497	Carcinoma, Hepatocellular	Results: Serum miR-497 showed statistically significant downregulation in HCC patients compared to controls (p < 0.001).
other	34576290	hsa-mir-203	Hypertension	These results indicate that IH stress downregulates the miR-203 in renin-producing cells, thereby resulting in increased mRNA levels of Ren and Cd38, which leads to hypertension.
genetics_GWAS	34576267	hsa-mir-499	Hashimoto   Thyroiditis	We examined whether miR-499 rs3746444 polymorphism is associated with susceptibility to HT in an Iranian subpopulation.
transcription factor target	34576110	hsa-mir-139	Squamous Cell Carcinoma of Head and Neck	3p in HNSCC cells was confirmed through luciferase reporter assays.
lncRNA target	34576039	hsa-mir-490	Colorectal Neoplasms	Thus, we have clarified a part of the molecular pathway of CRC based on the action of tumor-suppressive miR
other	34575979	hsa-mir-133a	Colonic Neoplasms	Further investigations showed a role of TPM4 in cancer physiology, specifically, we found that miR-133a downregulation leads to TPM4 upregulation in colon carcinoma (CRC), and this correlates with a lower patient survival. Interestingly, in CRC cell lines and in patient biopsies, miR-133a is able to regulate TPM4 activity, while TAp63 is not active.
other	34575957	hsa-mir-214	Liver Diseases	Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone.
other	34575957	hsa-mir-199a	Liver Diseases	Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone.
other	34575957	hsa-mir-99b	Fibrosis	3p and miR-99b-5p are promoters of HSC activation.
other	34575957	hsa-mir-99b	Liver Diseases	Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone.
other	34575957	hsa-mir-214	Fibrosis	3p and miR-99b-5p are promoters of HSC activation.
other	34575957	hsa-mir-199a	Fibrosis	3p and miR-99b-5p are promoters of HSC activation.
other	34575957	hsa-mir-125a	Fibrosis	3p and miR-99b-5p are promoters of HSC activation.
other	34575936	hsa-mir-144	beta-Thalassemia	3p was strongly increased; betaT-EVs induced apoptosis and decreased endothelial, pancreatic, and liver cell survival while supporting BM-MSC proliferation.
other	34575699	hsa-mir-20a	Autism Spectrum Disorder	Verification with qRT-PCR showed that miR-320a differentiated ASD from both sibling and unrelated controls and that several members of the miR-181 family differentiated ASD from unrelated controls.
other	34575699	hsa-mir-181	Autism Spectrum Disorder	Verification with qRT-PCR showed that miR-320a differentiated ASD from both sibling and unrelated controls and that several members of the miR-181 family differentiated ASD from unrelated controls.
genetics_GWAS	34575638	hsa-mir-126	Diabetes Mellitus, Type 2	Results indicated that there was a significant different (p-value < 0.05) in the Mir126 rs4636297 genotypes distribution between cases and controls, and the minor allele of the rs4636297 was also associated with T2D with OR = 0.58, p-value < 0.05. We conclude that the Mir126 rs4636297 and PIK3R1 SNPs (rs7713645 and rs3730089) were associated with T2D.
lncRNA target	34575183	hsa-mir-379	Breast Neoplasms	The target mRNAs (validated) of MiR-379/656 were annotated via pathway enrichment analysis to understand the biological significance of the cluster in breast cancer.
other	34574169	hsa-mir-222	Diabetes Mellitus	After analysing these results, a potential involvement of the reduced expression of miR-30c and miR-222, two microRNAs associated with insulin resistance and diabetes, in the improvement of glycaemic control produced by grape pomace administration, can be proposed.
other	34574169	hsa-mir-222	Insulin Resistance	After analysing these results, a potential involvement of the reduced expression of miR-30c and miR-222, two microRNAs associated with insulin resistance and diabetes, in the improvement of glycaemic control produced by grape pomace administration, can be proposed.
circulation_biomarker_diagnosis_ns	34574047	hsa-mir-431	Precancerous Conditions	In summary, our data reveal the diagnostic potential of circulating miR
circulation_biomarker_diagnosis_ns	34574047	hsa-mir-431	vulva squamous cell carcinoma	In summary, our data reveal the diagnostic potential of circulating miR
circulation_biomarker_diagnosis_ns	34574045	hsa-mir-122	Hyperparathyroidism, Primary	In conclusion, preoperative circulating miR5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients.
circulation_biomarker_diagnosis_ns	34574045	hsa-mir-375	Hyperparathyroidism, Primary	In conclusion, preoperative circulating miR5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients.
genetics_overexpression_promote	34573382	hsa-mir-200c	Carcinoma, Ovarian Epithelial	Our results suggest that inhibition of high expression of miR-200c-3p in EOC might lead to overexpression of the tumor suppressor PPP3CC and subsequent induction of apoptosis in EOC patients.
other	34573283	hsa-mir-200c	Burkitt Lymphoma	This study therefore identifies novel miRNAs as role players in the development of HIV-associated BL, with one of these miRNAs, hsa-miR-200c-3p, being a candidate for further clinical studies as a potential biomarker for prognosis in patients with Burkitt lymphoma, who are HIV positive.
transcription factor target	34573085	hsa-mir-43	Inflammation	These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle.
transcription factor target	34573085	hsa-mir-132	Inflammation	These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle.
transcription factor target	34573085	hsa-mir-21	Inflammation	These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle.
target gene	34572889	hsa-mir-137	Colorectal Neoplasms	miR-137 helps control MSH2 expression via its 3'UTR and that dysregulation of this mechanism appears to promote tumorigenesis in colon cells.
other	34572843	hsa-let-7i	Ovarian Neoplasms	Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer Cells.
other	34572608	hsa-mir-92a	Brain Neoplasms	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-106b	Primary Central Nervous System Lymphoma	5p.
other	34572608	hsa-mir-19a	Primary Central Nervous System Lymphoma	5p.
other	34572608	hsa-mir-92a	Primary Central Nervous System Lymphoma	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-15a	Primary Central Nervous System Lymphoma	5p.
other	34572608	hsa-mir-19a	Brain Neoplasms	5p.
other	34572608	hsa-mir-16	Primary Central Nervous System Lymphoma	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-21	Brain Neoplasms	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-26a	Primary Central Nervous System Lymphoma	5p.
other	34572608	hsa-mir-26a	Brain Neoplasms	5p.
other	34572608	hsa-mir-21	Primary Central Nervous System Lymphoma	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-16	Brain Neoplasms	5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity.
other	34572608	hsa-mir-15a	Brain Neoplasms	5p.
other	34572608	hsa-mir-106b	Brain Neoplasms	5p.
other	34572434	hsa-mir-6881	Non-alcoholic Fatty Liver Disease	CONCLUSION: This pilot study concluded that HSPD1/MMP14/ITGB1/miR5P/Lnc-SPARCL1-1:2 panel expression has potential in the diagnosis of NASH, and also differentiation between NAFLD, simple steatosis and NASH cases.
other	34572434	hsa-mir-6881	Carcinoma, Hepatocellular	CONCLUSION: This pilot study concluded that HSPD1/MMP14/ITGB1/miR5P/Lnc-SPARCL1-1:2 panel expression has potential in the diagnosis of NASH, and also differentiation between NAFLD, simple steatosis and NASH cases.
circulation_biomarker_diagnosis_up	34572320	hsa-mir-150	Diabetic Retinopathy	In cultured photoreceptors, treatments with palmitic acid (PA), to mimic a high-fat environment, decreased miR-150 but upregulated ELK1, pELK1(T417), and the translocation of pELK1(T417) from the cytoplasm to the cell nucleus. Deletion of miR-150 (miR-150(-/-)) exacerbates T2D- or PA-induced photoreceptor apoptosis.
transcription factor target	34572124	hsa-mir-43a	Depression	Our results indicate that the early life gamma-radiation-activated miR-43a-5p/Tia1 pathway is involved in the pathogenesis of adult depression. This novel finding may provide a new therapeutic target by inhibiting the miR-43a-5p/Tia1 pathway to prevent radiation-induced pathogenesis of depression.
lncRNA target	34572073	hsa-mir-124	Alzheimer Disease	Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor.
other	34572021	hsa-mir-451a	Prostatic Neoplasms	The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population.
other	34572021	hsa-mir-221	Prostatic Neoplasms	The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population.
other	34572021	hsa-mir-141	Prostatic Neoplasms	The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population.
other	34572021	hsa-mir-145	Prostatic Neoplasms	The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population.
other	34571940	hsa-mir-664a	Lichen Sclerosus et Atrophicus	We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue.
other	34571940	hsa-mir-326	Lichen Sclerosus et Atrophicus	We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue.
other	34571940	hsa-mir-181a	Lichen Sclerosus et Atrophicus	We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue.
other	34571940	hsa-mir-142	Lichen Sclerosus et Atrophicus	We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue.
lncRNA target	34571504	hsa-mir-425	Diabetic Retinopathy	Moreover, inhibiting the expression of miR5p levels under the condition of hyperglycemia may be used as a valuable therapeutic strategy for preventing the pathogenesis of DR.
genetics_overexpression_promote	34571345	hsa-mir-144a	Glioma	RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR
genetics_overexpression_promote	34571345	hsa-mir-144	Glioma	RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR
genetics_knock down_promote	34571083	hsa-mir-5096	Breast Neoplasms	induced ferroptotic cell death in human breast cancer cells was confirmed by concurrently increased ROS, OH(-), lipid ROS, and iron accumulation levels and decreased GSH and mitochondrial membrane potential (MitoTracker Orange) with mitochondrial shrinkage and partial cristae loss (observed by TEM).
other	34571048	hsa-mir-122	Acute Coronary Syndrome	5p do not add prognostic information to hs-cTnT in patients presenting with suspected ACS to the ED.
other	34571048	hsa-mir-21	Acute Coronary Syndrome	5p do not add prognostic information to hs-cTnT in patients presenting with suspected ACS to the ED.
other	34570885	hsa-mir-125b	Leukemia	We report that posttranscriptional repression of the transcription factor ARID3A by miR-125b is a key event in the pathogenesis of acute megakaryoblastic leukemia (AMKL).
circulation_biomarker_diagnosis_ns	34570814	hsa-mir-630	Weil Disease	Serum miR-601 and miR-630 at presentation could potentially serve as promising biomarkers for predicting subsequent acute liver failure and overall survival in patients with leptospirosis.
circulation_biomarker_diagnosis_ns	34570814	hsa-mir-601	Weil Disease	Serum miR-601 and miR-630 at presentation could potentially serve as promising biomarkers for predicting subsequent acute liver failure and overall survival in patients with leptospirosis.
lncRNA target	34570663	hsa-mir-1197	Carcinoma, Hepatocellular	In conclusion, circ_0004018 suppresses the proliferation and migration of HCC cells via sponging miR-1197 to inactivate the PTEN/PI3K/AKT signaling pathway.Abbreviations: HCC: Hepatocellular carcinoma; circRNAs: Circular RNAs; PTEN: Phosphatase and tensin homologue; miR-1197: microRNA-1197; ceRNA: competitive endogenous RNA; ATCC: American Type Culture Collection; EMEM: Eagle's Minimum Essential Medium; RT-qPCR: Quantitative real-time PCR; EdU: 5-ethynyl
lncRNA target	34570661	hsa-mir-200c	Glioblastoma	This information is exploited to evaluate the tumour suppressive function of miRNA-200c as locoregional therapeutic modality to treat glioblastoma.
other	34570349	hsa-mir-20a	Stroke	Intravenous injections, which are a therapeutically tractable treatment route, with miR-20a-3p mimic 4 h after middle cerebral artery occlusion (MCAo) significantly improved stroke outcomes including infarct volume and sensory motor performance.
transcription factor target	34570211	hsa-mir-204	Atherosclerosis	CONCLUSION: Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis.
genetics_overexpression_suppress	34569498	hsa-mir-3929	Uterine Cervical Neoplasms	Then, we analyzed the effect of miR-3929 on the biological behavior of cervical cancer cells, finding that miR-3929 could reduce cell viability, DNA synthesis, and Ki67 expression and induce cell cycle arrest in the G2/M phase; overexpression of Cripto-1 reversed the inhibitory effect of miR-3929 on proliferation.
genetics_knock down_promote	34569008	hsa-mir-615	Brachial Plexus Avulsion 	In this study, results indicated that hydrogel-miR-615 agomir effectively alleviated motoneuron loss by LINGO-1 inhibition, promoted musculocutaneous nerve regeneration and myelination, reduced astrocytes activation, promoted angiogenesis and attenuated peripheral amyotrophy, leading to improved motor functional rehabilitation of the upper extremity.
lncRNA target	34568801	hsa-mir-345	Polycystic liver disease	targeted proteins, cell proliferation, and cyst growth in vitro.
other	34568733	hsa-mir-146a	Abortion, Habitual	Objective To assess the relationship of miR-146aC G (rs2910164) and miR-196a2T C (rs11614913) with RPL susceptibility in Iranian women. Conclusion The results showed that although the distribution of miR-146aC G and miR-196a2T C was different between the unknown RPL and control groups, these variances were not statistically significant.
other	34568733	hsa-mir-196a	Abortion, Habitual	Objective To assess the relationship of miR-146aC G (rs2910164) and miR-196a2T C (rs11614913) with RPL susceptibility in Iranian women. Conclusion The results showed that although the distribution of miR-146aC G and miR-196a2T C was different between the unknown RPL and control groups, these variances were not statistically significant.
circulation_biomarker_diagnosis_ns	34568580	hsa-mir-122	Gastritis, Atrophic	CONCLUSION: These results suggested that serum exosomal hsa-miR
other	34568523	hsa-mir-432	Neurotic Disorders	Together, our results indicate that ADAR1 affects CUS-induced depressive-like behavior and BDNF expression by acting on miR-432 and circ_0000418.
other	34568463	hsa-mir-183	Heart Failure	3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients.
other	34568463	hsa-mir-183	Transposition of Great Vessels	3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients.
circulation_biomarker_diagnosis_ns	34568382	hsa-mir-6869	Obesity	Thus, miR5p in plasma Obese-EVs could be a therapeutic target for local RAS activation in obesity-associated kidney disease.
other	34568346	hsa-mir-423	Non-alcoholic Fatty Liver Disease	These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD.
other	34568346	hsa-mir-374a	Non-alcoholic Fatty Liver Disease	These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD.
other	34568346	hsa-mir-23a	Non-alcoholic Fatty Liver Disease	These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD.
other	34568346	hsa-mir-1	Non-alcoholic Fatty Liver Disease	5p and miR-200c-3 in regulating apoptotic processes in the liver and hepatocarcinogenesis is of interest for future experimental studies.
other	34568346	hsa-mir-200c	Non-alcoholic Fatty Liver Disease	5p and miR-200c-3 in regulating apoptotic processes in the liver and hepatocarcinogenesis is of interest for future experimental studies.
other	34568346	hsa-mir-143	Non-alcoholic Fatty Liver Disease	These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD.
exosome	34568335	hsa-mir-375	Carcinoma, Hepatocellular	Moreover, HCC-secreted EXOs mediated the degradation of miR-375 via circ-0072088 and upregulated MMP-16, thus suppressing the metastasis of HCC.
other	34568326	hsa-mir-1252	Osteosarcoma	Circular RNA hsa_circ_0000073 Enhances Osteosarcoma Cells Malignant Behavior by Sponging miR-1252-5p and Modulating CCNE2 and MDM2.
lncRNA target	34568062	hsa-mir-4732	Carcinoma, Hepatocellular	3p/ULBP1 axis may regulate immune escape via PD-L1 in HCC with high TMB.
circulation_biomarker_diagnosis_ns	34567283	hsa-mir-651	Uterine Cervical Neoplasms	Herein, we observed the roles of exosomal miR-651 in cisplatin resistance of cervical cancer. METHODS: Circulating miR-651 was detected in cervical cancer and healthy individuals.
genetics_overexpression_promote	34567205	hsa-let-7	Colonic Neoplasms	Methods It was planned to synthesize miR-let-7 overexpression (mimics) and interference expression (inhibitor) and transiently transfect colon cancer cell HCT116, detect the expression levels of miR-let-7 and HMGA2 in the cells after transfection and the targeted regulation effect of miR-let-7 on HMGA2, then detect the effect of upregulation/downregulation of miR-let-7 on HMGA2, and detect the proliferation, migration, and invasion of HCT116 cells.
transcription factor target	34567186	hsa-mir-218	Breast Neoplasms	We aimed to investigate the frequency of EBV and its relationship with expression status of tumor suppressive miR-218 in breast cancer and adjacent normal tissue.
transcription factor target	34567186	hsa-mir-218	Epstein-Barr Virus Infections	We aimed to investigate the frequency of EBV and its relationship with expression status of tumor suppressive miR-218 in breast cancer and adjacent normal tissue.
other	34567091	hsa-mir-200c	Carcinoma, Hepatocellular	Result: The key regulatory genes including EXO1, VCAN, KIT, and hsa-miR-200c-5p were found to play vital roles in HCV-HCC development.
other	34567091	hsa-mir-200c	Hepatitis C	Result: The key regulatory genes including EXO1, VCAN, KIT, and hsa-miR-200c-5p were found to play vital roles in HCV-HCC development.
circulation_biomarker_diagnosis_ns	34567071	hsa-mir-146a	Heart Septal Defects, Ventricular	hsa-miR-146a-5p was identified to be capable of distinguishing VSD cases from controls (area under the ROC curve [AUC]: 0.997; p < 1.00E-05). Conclusion: Circulating exosomal miRNAs, particularly hsa-miR-146a-5p, may be predictive biomarkers for the non-invasive prenatal diagnosis of fetal VSDs.
circulation_biomarker_diagnosis_ns	34567065	hsa-mir-182	Diabetes Mellitus, Type 2	We therefore aimed to investigate the expressions of circulating miRNAs (miR-30a-5p, miR-1299, miR
lncRNA target	34566408	hsa-mir-214	Liver Neoplasms	CONCLUSION: In this work, we determined that ketamine suppressed viability of liver cancer cells and induced ferroptosis and identified the possible regulatory mechanism of lncPVT1/miR
genetics_knock down_suppress	34565758	hsa-mir-26b	Thyroid Cancer, Papillary	Through dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay, microRNA-26b-5p (miR-26b-5p) was identified to be the intermediary molecular between circ_0079558 and MET, and circ_0079558 knockdown reduced the expression of MET partly through elevating miR-26b-5p in PTC cells. In conclusion, circ_0079558 facilitated the proliferation and motility whereas inhibited the apoptosis of PTC cells largely through mediating miR-26b-5p/MET/AKT signaling.
transcription factor target	34565303	hsa-mir-140	Cartilage Diseases	5p repressed chondrocyte pyroptosis and alleviated OA cartilage injury via inhibition of the CTSB/NLRP3.
transcription factor target	34565303	hsa-mir-140	Osteoarthritis	5p repressed chondrocyte pyroptosis and alleviated OA cartilage injury via inhibition of the CTSB/NLRP3.
circulation_biomarker_diagnosis_up	34565302	hsa-mir-378a	Sepsis	Serum miR-378a-3p was increased in sepsis patients and rat model.
circulation_biomarker_diagnosis_up	34565302	hsa-mir-378a	Inflammation	Serum miR-378a-3p was increased in sepsis patients and rat model.
other	34565286	hsa-mir-106b	Carcinoma, Hepatocellular	Further investigation suggested that LOC107985656 regulated the expression of LATS1 by acting as a sponge for absorbing miR-106b-5p in HCC cells. In conclusion, this study unraveled the role of LOC107985656 following a ceRNA (competing endogenous RNAs) mechanism for the miR-106b-5p/LATS1 axis in HCC.
genetics_overexpression_promote	34565284	hsa-mir-640	Carcinoma, Renal Cell	Besides, miR-640 downregulation or NPTX2 overexpression partly overturned the tumor suppressor function of circ_0054537 silence and miR-640 overexpression in RCC cells. In conclusion, circ_0054537/miR-640/NPTX2 ceRNA pathway regulated RCC malignant progression in vitro and curbed RCC tumor growth in vivo, which could be a potential diagnosis and therapeutic target of RCC.
circRNA target	34565283	hsa-mir-488	Stomach Neoplasms	From our results, we showed that hsa_circ_0000751 may serve as a miRNA sponge to suppress the activity of miR-488, thereby increasing the expression of the miRtarget gene, UQCRC2, and limiting GC progression.
genetics_overexpression_suppress	34565010	hsa-mir-363	Urinary Bladder Neoplasms	In addition, overexpression of BTG2 reversed the inhibitory effect of miR
circulation_biomarker_diagnosis_ns	34565002	hsa-mir-103	Lung Neoplasms	Serum levels of miR-103 and HDL were significantly enhanced in lung carcinoma patients achieving PR after chemotherapy (p<0.05).
lncRNA target	34565000	hsa-let-7a	Carcinoma, Non-Small-Cell Lung	Herein, we investigated the effects of let-7a targets Rsf-1 on modulating the radiotherapy response in NSCLC cells by Ras-MAPK pathway. The present study provides evidence that let-7a targeting Rsf-1 can modulate radiotherapy response in NSCLC cells through Ras-MAPK pathway.
circulation_biomarker_prognosis_ns	34564990	hsa-mir-509	Carcinoma, Hepatocellular	RESULTS: qRT-PCR and starBase analysis showed that the miR-187 expression was low in the tissues and serum of primary HCC patients, while that of miR
other	34564949	hsa-mir-155	Alopecia Areata	OBJECTIVES: We aimed at exploring the association between some miRNAs lesional expression and AA pathogenesis by measurement of miRNAs-155, 146a, and 203 expression levels in the lesional skin from patchy AA patients and to evaluate their relation with the studied parameters. SUBJECTS AND METHODS: Skin expression levels of miRNAs-155, 146a, and 203 were evaluated in 50 patients with patchy AA and 25 healthy controls using reverse transcriptase-quantitative PCR (RT-qPCR).
genetics_overexpression_promote	34564768	hsa-mir-497	Carcinoma, Hepatocellular	5p inhibitors and or HMGA2 overexpression partially counteracted the suppressing effect induced by si-circ-CCND1 on the malignant phenotype of HCC cells.
genetics_knock down_promote	34564700	hsa-mir-126	Leukemia, Myeloid, Chronic-Phase	Spred1 KO, regardless if occurred in HSCs or in ECs, increased miR-126 in LSKs (Lin(-)Sca-1(+)c-Kit(+)), a population enriched in leukemic stem cells (LSCs), resulting in expansion of LSCs, likely through hyperactivation of the MAPK/ERK pathway that augmented Bcl-2 expression and stability.
other	34564643	hsa-mir-133a	Cardiotoxicity	No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy.
lncRNA target	34563560	hsa-mir-142	Post-Dural Puncture Headache	However, which genes are targeted by miR
lncRNA target	34563560	hsa-mir-17	Post-Dural Puncture Headache	However, which genes are targeted by miR
genetics_overexpression_promote	34563514	hsa-mir-125b	Cardiomyopathies	Overexpression of miR-125b mitigated myocardial dysfunction induced by CLP in vivo.
circulation_biomarker_diagnosis_ns	34563222	hsa-mir-410	Cancer-Associated Cachexia	3p was higher in subcutaneous adipose tissues and serum exosomes of CAC patients, which significantly inhibits adipogenesis and lipid accumulation.
circulation_biomarker_prognosis_up	34562827	hsa-mir-134	Stomach Neoplasms	5p in the cytoplasm of GC tissue cells.
genetics_GWAS	34562686	hsa-mir-200	Breast Neoplasms	Thus, this study provides the initial foundation for using miR-200s for breast cancer prevention and additional studies should be performed to identify strategies for increasing mammary miR-200 expression and determine whether miR-200s can prevent mammary tumor initiation by other genetic alterations.
genetics_overexpression_promote	34562605	hsa-mir-335	Thyroid Cancer, Papillary	5p restoration inhibited proliferation, angiogenesis and radioresistance in PTC cells, while YAP1 overexpression abolished these effects.
circRNA target	34562344	hsa-mir-942	Uterine Cervical Neoplasms	5p was identified as a downstream target of circ_0000730, and circ_0000730 could positively regulate PTEN expression via repressing miR
lncRNA target	34562123	hsa-mir-650	Colorectal Neoplasms	CONCLUSION: This study highlighted that MIR155HG, by regulating the miR-650/ANXA2 axis, promotes CRC progression and enhances oxaliplatin resistance in CRC cells through M2 macrophage polarization.
genetics_knock down_promote	34562091	hsa-mir-142	Retinoblastoma	Cotransfection of PTEN overexpression plasmids reversed the influences of miR
lncRNA target	34561554	hsa-mir-183	Breast Neoplasms	5p and the efficacy of PLK1-specific inhibitors in breast cancer cells.
lncRNA target	34561425	hsa-mir-765	Esophageal Squamous Cell Carcinoma	Our findings revealed a novel lncRNA RP11-465B22.8/miR-765/KLK4 pathway in EC and indicated that lncRNA RP11-465B22.8 might be a potential target for EC therapy.
lncRNA target	34560673	hsa-mir-204	Osteoarthritis	induced stimulation of IL-1beta in human OASFs occurred via the suppression of miR
lncRNA target	34560556	hsa-mir-382	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-200a	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-140	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-200c	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-15b	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-93	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-148a	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560556	hsa-mir-138	Colorectal Neoplasms	5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state.
lncRNA target	34560189	hsa-mir-665	Glioma	RNF144A-AS1 up-regulated the expression of HMGA1 by targeting miR-665, thereby promoting the development of glioma cells.
genetics_overexpression_promote	34559955	hsa-mir-103a	Osteosarcoma	More interestingly, miR-103a-3p depletion or SIK2 overexpression restored the impacts of down-regulated LINC00662 on OS cells.
lncRNA target	34559933	hsa-mir-199a	Glioma	Rescue experiments were conducted to explore the function of CDKN2B-AS1 and miR-199a-5p in glioma. CONCLUSION: Our study reveals that CDKN2B-AS1 promotes glioma development by regulating the miR-199a-5p/DDR1 axis, suggesting that this lncRNA might be a potential therapeutic target.
circRNA target	34559381	hsa-mir-1184	Breast Neoplasms	In conclusion, we demonstrate that circ_0001598/miR-1184/PD-L1 signaling plays a crucial role in the regulation of BC progression and trastuzumab-resistance phonotypes, which suggests that circ_0001598 may be a molecular target to treat HER2-positive BC patients.
lncRNA target	34559207	hsa-mir-26b	Osteoarthritis	Cellular and molecular analyses showed that asporin can be inhibited by miR-26b-5p, which was significantly downregulated in OA cartilage, leading to exacerbation of experimental OA partially through inhibition of TGF-beta1-Smad2 signalling in chondrocytes.
genetics_overexpression_suppress	34559194	hsa-mir-23a	Arthritis, Juvenile	Despite enhanced reactive oxygen species (ROS) levels within the local inflammatory milieu, JIA T cells are hyperproliferative and reveal an overexpression of miR-23a, which is an inhibitor of Peptidyl-prolyl isomerase F (PPIF), the regulator of mitochondrial ROS escape.
lncRNA target	34558803	hsa-mir-29b	Coronary Stenosis	MIAT participated in the development of CAD via miR-29b-3p/PAPPA axis.
lncRNA target	34558803	hsa-mir-29b	Coronary Artery Disease	MIAT participated in the development of CAD via miR-29b-3p/PAPPA axis.
transcription factor target	34558654	hsa-mir-218	Glioma	Our data revealed a previously unknown tumor suppressor role of miR218 by blocking the TNC/AKT/AP1/TGFbeta1positive feedback loop in glioma.
lncRNA target	34558643	hsa-mir-206	Carcinoma, Non-Small-Cell Lung	PTMA is a target of miR206 and silencing CYTOR inhibited PTMA expression via miR206, thus promoting radiosensitivity of NSCLC cells.
lncRNA target	34558639	hsa-mir-383	Adenocarcinoma of Lung	In the present study, an association between the downregulation of miR383 expression and the deletion of chr8p22 in patients with lung adenocarcinoma was identified. Taken together, the downregulation of miR383 induced RBM24 expression, which was mediated through the activation of NFkappaB signaling, to contribute to chemotherapy resistance in lung adenocarcinoma cells.
genetics_knock down_promote	34558634	hsa-mir-205	Rhinitis, Allergic	In conclusion, the present findings suggested that miR2055p knockdown may attenuate the inflammatory response in AR by targeting BCL6, which may be a potential therapeutic target for AR.
other	34558538	hsa-mir-124	Brain Injuries, Traumatic	These findings suggest that HOXA11-AS can aggravate neuroinflammation after traumatic brain injury by modulating the miR3p-MDK axis.
other	34558393	hsa-mir-224	Atherosclerosis	The expression level of lncSNHG8 was increased in AS patients, while miR3p expression was decreased.
lncRNA target	34558385	hsa-mir-29c	Pneumonia	Disruption of MEG3 alleviated cell injury and inflammation as characterized by high LPS by binding miR-29 c.
circulation_biomarker_diagnosis_ns	34558328	hsa-mir-19a	Carotid Stenosis	Furthermore, the level of serum miR-19a-3p (hazard ratio [HR] = 8.507, 95% confidence interval [CI] = 2.239-32.328, P = .002) and degree of artery stenosis (HR = 3.695, 95% CI = 1.127-12.109, P = .031) were independent predictors of occurrence of CIE.
circulation_biomarker_diagnosis_ns	34558328	hsa-mir-19a	Brain Ischemia	Furthermore, the level of serum miR-19a-3p (hazard ratio [HR] = 8.507, 95% confidence interval [CI] = 2.239-32.328, P = .002) and degree of artery stenosis (HR = 3.695, 95% CI = 1.127-12.109, P = .031) were independent predictors of occurrence of CIE.
lncRNA target	34558284	hsa-mir-133b	Heart Diseases	These results indicate that an oil-induced increase in miR133b may contribute to cardiac abnormalities in oil-exposed fish by targeting cardiac-specific genes essential for proper heart development.
other	34558239	hsa-mir-16	Depression	OBJECTIVE: To observe the effect of Mongolian medicine three-acupoints balance needling on the expression of p11/tPA/BDNF pathway and miRNA-16 in the hippocampus and middle raphe nucleus (MRN) in chronic stress depression model rats, so as to explore its mechanisms underlying improvement of depression. CONCLUSION: Mongolian medicine three-acupoints balance needling can improve the depressive state in depression rats, which may be associated with its effects in up-regulating the expression of p11 and tPA proteins and BDNF mRNA in the hippocampus and MRN and in down-regulating miRNA-16 in the hippocampus, suggesting an involvement of miRNA-16 controlled p11/tPA/BDNF signaling pathway in the antidepressant effect of acupuncture.
lncRNA target	34557649	hsa-mir-721	Alzheimer Disease	5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.
lncRNA target	34557649	hsa-mir-196b	Alzheimer Disease	5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.
lncRNA target	34557649	hsa-mir-376b	Alzheimer Disease	5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.
lncRNA target	34557649	hsa-mir-34a	Alzheimer Disease	5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.
target gene	34557255	hsa-mir-635	Multiple Myeloma	circ_0058063 expression increased in multiple myeloma tissues. Knocking down its expression may inhibit myeloma proliferation, migration, and invasion by targeting and upregulating miR-635 and also promote cell apoptosis.
other	34556996	hsa-mir-200c	Pancreatic Neoplasms	Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions.
exosome	34556984	hsa-mir-136	Carcinoma, Non-Small-Cell Lung	5p antagomir packaging into anlotinib-resistant NSCLC cell-derived exosomes functionally restored NSCLC cell anlotinib sensitivity in vitro.
genetics_knock down_suppress	34556632	hsa-mir-944	Stomach Neoplasms	In vitro experiments demonstrated that circHAS2 knockdown or the addition of hsa-miR-944 mimics inhibited the proliferation, migration, and invasion ability of GC cells and affected the epithelial-mesenchymal transition. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC; thus, circHAS2 may be a potential biomarker and therapeutic target for GC.
exosome	34555810	hsa-mir-422a	Ovarian Neoplasms	CONCLUSIONS: Foxo3 promoted OC progression through exosome-mediated intercellular interaction to target miR-422a/PLP2 axis.
target gene	34555726	hsa-mir-520	Osteosarcoma	Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression.
virus_miRNA	34555439	ebv-mir-BART2	Stomach Neoplasms	MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer
lncRNA target	34554926	hsa-mir-19b	Intervertebral Disc Degeneration	This research confirmed that miR-19b-3p suppressed HNPC apoptosis in the in-vitro model of IVDD by regulating PTEN/PI3K/Akt/mTOR pathway.
genetics_knock down_promote	34554678	hsa-mir-100	Ventricular Premature Complexes	Moreover, we found that circ_0004104 could sponge miR-100 and a miR-100 inhibitor could reverse the inhibition effect of circ_0004104 knockdown on ox-LDL-induced VEC injury.
other	34554678	hsa-mir-100	Coronary Artery Disease	Our results revealed that circ_0004104 was upregulated and miR-100 was downregulated in patients with CAD and ox-LDL-induced VECs. Our data suggested that circ_0004104 promoted ox-LDL-induced VEC injury by the miR-100/TNFAIP8 axis, indicating that circ_0004104 might be a potential biomarker for CAD treatment.
other	34554676	hsa-mir-30	Atherosclerosis	Moreover, MALAT1 regulated NF-kappaB signal pathway to mediate the pathogenesis of AS by sponging miR5p.
lncRNA target	34554275	hsa-mir-142	Inflammation	CONCLUSION: Upon MG infection, upregulation of gga-miR3p alleviates inflammation by negatively regulating the signaling pathways of NF-kappaB and MAPKs by targeting TAB2 and facilitates cell proliferation by inhibiting cell apoptosis and promoting cell cycle progression to defend against MG infection.
lncRNA target	34554275	hsa-mir-142	Myasthenia Gravis	3p alleviates inflammation by negatively regulating the signaling pathways of NF-kappaB and MAPKs by targeting TAB2 and facilitates cell proliferation by inhibiting cell apoptosis and promoting cell cycle progression to defend against MG infection.
other	34553694	hsa-mir-452	Colorectal Neoplasms	These results suggest that MIR452 might directly or indirectly regulate the genes transcription related to CRC by downregulating GTF2E1 expression.
other	34553456	hsa-mir-133b	Cardiomyopathies	The current work reveals a unique role of the TUG1/miR-133b/CTGF axis in MF, thus suggesting its immense therapeutic potential in the treatment of cardiac diseases.
lncRNA target	34553450	hsa-mir-873	Myocardial Reperfusion Injury	Retraction: Methyltransferase-like 3 (METTL3) attenuates cardiomyocyte apoptosis with myocardial ischemia-reperfusion (I/R) injury through miR
lncRNA target	34553078	hsa-mir-182	Diabetic Nephropathies	CONCLUSION: Taken together, MIAT functioned as an inhibitory factor in the pathogenesis to impede the development of DN and inactivate the NF-kappaB pathway via regulating the miR5p/GPRC5A axis.
other	34553033	hsa-mir-137	Stomach Neoplasms	lncRNA DSCR8 mediates miR-137/Cdc42 to regulate gastric cancer cell proliferation, invasion, and cell cycle as a competitive endogenous RNA.
transcription factor target	34553025	hsa-mir-519d	Carcinoma, Non-Small-Cell Lung	This showed that miR-519d-3p can be used as a diagnostic biomarker and target therapy for NSCLC.
lncRNA target	34553021	hsa-mir-10a	Carcinoma, Renal Cell	The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 ceRNA network related to the prognosis of KIRC was obtained through bioinformatics analysis based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.
exosome	34552961	hsa-mir-26a	Carcinoma, Hepatocellular	Furthermore, anti-GPC3 scFv-modified exosomes effectively delivered miR-26a to GPC3-positive hepatocellular carcinoma cells, thereby inhibiting cell proliferation and migration by regulating the expression of downstream target genes of miR-26a.
other	34552925	hsa-mir-17	Stomach Neoplasms	CONCLUSION: The study unveiled that the LncRNA NEAT1/miR5p/TGFbetaR2 axis is a novel mechanism in GC angiogenesis.
other	34552821	hsa-mir-21	Obesity	Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations.
lncRNA target	34552818	hsa-mir-149	Stomach Neoplasms	5p/CCDC6 axis might be developed as a therapeutic target and prognostic indicator for GC.
transcription factor target	34552061	hsa-mir-9	Breast Neoplasms	The study proved that miR3p regulates biological functions, drug resistance, and the growth of Gem-treated breast cancer cells through targeting MTDH.
lncRNA target	34552050	hsa-mir-497	Pancreatic Carcinoma	5p acted as a tumour suppressor gene in pancreatic cancer by targeting HMGA2.
transcription factor target	34552038	hsa-mir-21	Brain Ischemia	Our data uncover a novel mechanism of miR-21 in regulating cerebral ischemic neuronal injury by inhibiting p53/Bcl-2/Bax signaling pathway, which suggests that miR-21/p53 may be attractive therapeutic molecules for treatment of ischemic stroke.
genetics_knock down_promote	34551979	hsa-mir-210	succinic semialdehyde dehydrogenase deficiency	In exploring mechanisms of SDH down-regulation in ccRCC, we report that Von Hippel-Lindau loss-induced hypoxia-inducible factor-dependent up-regulation of miR-210 causes direct inhibition of the SDHD transcript.
genetics_knock down_promote	34551979	hsa-mir-210	Carcinoma, Renal Cell	In exploring mechanisms of SDH down-regulation in ccRCC, we report that Von Hippel-Lindau loss-induced hypoxia-inducible factor-dependent up-regulation of miR-210 causes direct inhibition of the SDHD transcript.
genetics_knock down_promote	34551785	hsa-mir-202	Pancreatic Carcinoma	We then carried out gain- and loss-of function of miR
transcription factor target	34551709	hsa-mir-20	Osteoarthritis	CONCLUSION: Suppression of CRLF1 promotes the chondrogenic differentiation of BMSCs and protects cartilage tissue from damage in osteoarthritis via activation of miR-320.
genetics_knock down_promote	34551673	hsa-mir-186	Uterine Cervical Neoplasms	Knockdown of IGF1 reversed the results of miR
genetics_GWAS	34551209	hsa-mir-143	Coronary Artery Disease	Whether SNPs within the genomic sequence of the miR-143/145 cluster are involved in cardiovascular disease development is not known.
genetics_GWAS	34551209	hsa-mir-145	Coronary Artery Disease	Whether SNPs within the genomic sequence of the miR-143/145 cluster are involved in cardiovascular disease development is not known.
lncRNA target	34551195	hsa-mir-7	Lung Neoplasms	The research suggests that the circ-WHSC1/miR-7/TAB2 axis might be a potential target for NSCLC therapy.
genetics_knock down_promote	34550549	hsa-mir-34a	Stomach Neoplasms	LINC01106 knockdown led to the suppression of cell invasion, migration, and viability, whereas these effects caused by LINC01106 knockdown were reversed by miR-34a-5p down-regulation or MYCN up-regulation in GC cells.
circulation_biomarker_diagnosis_down	34550352	hsa-mir-4446	Acromegaly	CONCLUSIONS: In a 2-phase experiment using 2 different techniques we found and validated the downregulation of plasma miR
circulation_biomarker_diagnosis_down	34550352	hsa-mir-215	Acromegaly	CONCLUSIONS: In a 2-phase experiment using 2 different techniques we found and validated the downregulation of plasma miR
lncRNA target	34549308	hsa-mir-125a	Breast Neoplasms	All these data suggested that miR125a5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer and, therefore, has potential as a novel therapeutic target for this disease.
lncRNA target	34548487	hsa-mir-194	Stomach Neoplasms	Silencing KLF5 augmented GC cell autophagy, apoptosis and impeded its viability through the DANCR/miR-194/AKT2 axis.
genetics_overexpression_promote	34548334	hsa-mir-155	Lymphoma	miRNA-155 (miR-155) is overexpressed in various types of lymphomas and leukemias, suggesting that targeting miR-155 could be a potential platform for the development of precision medicine.
transcription factor target	34547965	hsa-mir-130a	Retinoblastoma	CONCLUSIONS: miR-130a-3p enhanced the chemosensitivity of Y79 RB cells to VCR by targeting PAX6 expression.
circulation_biomarker_diagnosis_up	34547828	hsa-mir-628	Dermatitis, Atopic	CONCLUSION: Our new findings suggest that the plasma miR
other	34547756	hsa-mir-378a	Obesity	RESULTS: miR-146a, miR-155, and miR-378a were upregulated in overweight mothers, while miR-378a was upregulated in obese mothers compared to normal weight mothers. In vitro exposure to high triglyceride and exposure to miR-378a induced a higher expression of PPAR-gamma in cells from offspring of mothers with overweight and obesity.
other	34547756	hsa-mir-378a	Obesity, Maternal	RESULTS: miR-146a, miR-155, and miR-378a were upregulated in overweight mothers, while miR-378a was upregulated in obese mothers compared to normal weight mothers. In vitro exposure to high triglyceride and exposure to miR-378a induced a higher expression of PPAR-gamma in cells from offspring of mothers with overweight and obesity.
lncRNA target	34547282	hsa-mir-802	Pancreatitis	CONCLUSIONS: We show miR-802 suppresses pancreatic cancer initiation by repressing oncogenic Kras-induced ADM.
lncRNA target	34547245	hsa-mir-17	Vascular Diseases	Overall, LIPUS irradiation prevents AngII-induced RAVSMCs phenotypic switching through hampering miR5p and enhancing PPAR-gamma, suggesting a new approach for the treatment of vascular disorders.
other	34547186	hsa-mir-16	Heart Diseases	CONCLUSION: Our study is the first to report the abnormal expression of CAIF and miR-16 in heart disease.
circulation_biomarker_diagnosis_down	34547186	hsa-mir-16	Heart Failure	RESULTS: The expression levels of CAIF and miR-16 were downregulated in the plasma of sepsis-induced CHF patients and were positively correlated in these patients.
circulation_biomarker_diagnosis_down	34547186	hsa-mir-16	Sepsis	RESULTS: The expression levels of CAIF and miR-16 were downregulated in the plasma of sepsis-induced CHF patients and were positively correlated in these patients.
lncRNA target	34547172	hsa-mir-144	Heart Failure, Ischemic	3p/Nrf2 axis, which may be a new treatment target for renal I/R injury.
genetics_overexpression_promote	34547134	hsa-mir-221	Squamous Cell Carcinoma of Head and Neck	RESULTS: SCIRT and GAS5 were downregulated, while miR-221 was overexpressed in OSCC.
exosome	34546854	hsa-mir-1224	Squamous Cell Carcinoma of Head and Neck	To sum up, our study demonstrated that exosomal APCDD1L-AS1 conferred resistance to 5-FU in HSC-3/5-FU and HN-4/5-FU cells via the miR
genetics_knock down_promote	34546850	hsa-mir-153	Endometriosis	3p inhibition could abrogate the impacts of circPIP5K1A knockdown on EM progression in vitro.
other	34546840	hsa-mir-4649	Nasopharyngeal Carcinoma	The results suggest that LINC02570 is upregulated in late clinical stage NPC patients, and promotes NPC progression by adsorbing miR3p to up-regulate SREBP1 and FASN.
circRNA target	34546569	hsa-mir-503	Uterine Cervical Neoplasms	CircSAMD11 contributed to CC progression by regulating miR-503/SOX4 signalling and activating Wnt/beta-catenin pathway, which provides a promising therapeutic target for cervical cancer.
genetics_GWAS	34546460	hsa-mir-182	Hypertension, Pulmonary	Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming growth factor (TGF)-beta signalling pathways, which are disturbed in PAH.
genetics_GWAS	34546460	hsa-mir-182	Diabetic Retinopathy	Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming growth factor (TGF)-beta signalling pathways, which are disturbed in PAH.
genetics_overexpression_promote	34546403	hsa-mir-214	Liver Cirrhosis	CONCLUSION: Hepatic overexpression of miR-214 is associated with progression of liver fibrosis in patients with BA, and the circulating miR-214 level may serve as a non-invasive predictor of liver fibrosis.
genetics_overexpression_promote	34546403	hsa-mir-214	Biliary Atresia	CONCLUSION: Hepatic overexpression of miR-214 is associated with progression of liver fibrosis in patients with BA, and the circulating miR-214 level may serve as a non-invasive predictor of liver fibrosis.
genetics_knock down_suppress	34545676	hsa-mir-423	Diabetes Mellitus	5p knockdown in ADSCs ameliorated high glucose-mediated damage to HUVECs and improved erectile function in DM rats by inducing eNOS and VEGFa overexpression, indicating that miR
lncRNA target	34545623	hsa-mir-630	Osteosarcoma	CONCLUSION: Circ-MTO1 and miR-630 expressions are inter-correlated and dysregulated in osteosarcoma patients.
lncRNA target	34544967	hsa-mir-1303	Cardiotoxicity	In this study, we investigated the role and mechanism of circ-SKA3 in DOX-induced cardiotoxicity.The quantitative real-time polymerase chain reaction and western blot assays were applied to measure the expression of circ-SKA3, microRNA (miR) -1303, and toll-like receptor 4 (TLR4). Additionally, circ-SKA3 contributed to DOX-induced cardiotoxicity through the miR-1303/TLR4 axis.
exosome	34544909	hsa-mir-34c	Infantile convulsions and paroxysmal choreoathetosis, familial	M1 macrophages derived exosomes miR-34c-5p decreased ICCs cell viability by directly targeting SCF.
other	34544531	hsa-mir-455	Uterine Cervical Neoplasms	5p test by nano-PCR.
circulation_biomarker_diagnosis_up	34544412	hsa-mir-1180	Melanoma	3p in melanoma patient plasma is a promising diagnostic marker and provides novel insight into melanoma development.
circRNA target	34544313	hsa-mir-140	Osteoarthritis	Circ_0128846 contributes to OA development through acting as a sponge RNA for miR
other	34543801	hsa-mir-100	Carcinoma, Pancreatic Ductal	Finally, we observed that miR5p promoted Panc-1 and BxPC3 cell growth in vitro and in vivo.
genetics_knock down_promote	34543800	hsa-mir-200c	Thyroid Cancer, Papillary	Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect.
lncRNA target	34543777	hsa-let-7i	Carcinoma, Non-Small-Cell Lung	RESULTS: DICER was highly expressed in DDP-resistant NSCLC tissues and cells, and DICER could target and negatively regulate the expression of let-7i-5p. CONCLUSION: Our research suggests that DICER promotes autophagy and DDP resistance in NSCLC through downregulating let-7i-5p, and inhibits the activation of PI3K/AKT/mTOR pathway.
transcription factor target	34543287	hsa-mir-155	Colitis	Our findings indicate that chronic colitis impairs heart function through an IL-1beta-->miR>BDNF signaling axis.
other	34543233	hsa-mir-29b	Parkinson Disease	Conclusively, miR-29b2/c is involved in the regulation of aging and plays a detrimental role in Parkinson's disease.
transcription factor target	34542842	hsa-mir-29a	Osteoarthritis	miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA.
lncRNA target	34542739	hsa-mir-511	Stomach Neoplasms	Our research suggested that tumor-suppressive function of miR
circulation_biomarker_diagnosis_up	34542403	hsa-mir-181a	Muscular Atrophy, Spinal	RESULTS: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, 5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients.
other	34542165	hsa-mir-424	Melanoma	Collectively, the findings of the present study suggested that TINCR may attenuate the progression of CMM by regulating the miR4245p/LATS1 signaling axis.
other	34542164	hsa-mir-335	Myocardial Injury	In conclusion, the upregulation of miR335 exerted ameliorative effects on myocardial injury following sepsis and may indicate a novel therapeutic intervention for SIMI.
other	34542164	hsa-mir-335	Cardiomyopathies	In conclusion, the upregulation of miR335 exerted ameliorative effects on myocardial injury following sepsis and may indicate a novel therapeutic intervention for SIMI.
genetics_knock down_promote	34542161	hsa-mir-495	Urinary Bladder Neoplasms	Moreover, circBIRC6 knockdown notably attenuated the proliferation, invasion, migration and EMT of BC cells, which was blocked by the miR4953p inhibitor. In conclusion, these findings demonstrated that circBIRC6 knockdown suppressed BC tumorigenesis and progression via regulation of the miR4953p/XBP1 signaling axis, offering a promising therapeutic target for the treatment of BC.
lncRNA target	34542064	hsa-mir-144	Colonic Neoplasms	CONCLUSION: In summary, this study reveals critical roles and molecular mechanisms of the HCG11-mediated 5-FU resistance through modulating the miR
lncRNA target	34542062	hsa-mir-205	Squamous Cell Carcinoma of Head and Neck	5p were determined via quantitative real-time-PCR in fresh frozen tissues of 26 p16-positive, 19 p16-negative OPSCCs and 18 HPV-negative oropharyngeal controls.
other	34542062	hsa-mir-182	Squamous Cell Carcinoma of Head and Neck	5p in p16-positive and p16-negative oropharyngeal squamous cell carcinomas (OPSCCs).
other	34541816	hsa-mir-221	Atherosclerosis	miR-221 was highly expressed while SIRT1 was poorly expressed in AS. In conclusion, LincRNA-p21 acted as a molecular sponge for miR-221 to promote deacetylation of the promoter region of Pcsk9 by SIRT1, therefore preventing the development of AS.
genetics_knock down_promote	34541682	hsa-mir-506	Ovarian Neoplasms	3p overexpression suppressed PTX resistance and malignant behaviors of PTX-resistant OC cells, with NFIB elevation rescued the impacts.
tissue_expression_ns	34541347	hsa-mir-1307	Urinary Bladder Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Pancreatic Carcinoma	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Sarcoma	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Ovarian Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Biliary Tract Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Colonic Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Esophageal Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Prostatic Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Liver Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Brain Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Lung Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	Breast Neoplasms	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
tissue_expression_ns	34541347	hsa-mir-1307	hereditary diffuse gastric cancer	We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip.
circulation_biomarker_diagnosis_ns	34540908	hsa-mir-29b	Atrial Fibrillation	Results: Elevated levels of TUG1 and low expression of miR-29b-3p were detected in the serum of AF patients compared with the healthy controls. Pearson's correlation analysis exhibited an inverse relationship between TUG1 and miR-29b-3p expression in AF patients (r = -7.106, p < 0.001).
circulation_biomarker_prognosis_up	34540745	hsa-mir-221	Depression, Postpartum	3p in serum and CSF can be used as the diagnostic and risk warning indicators of PSD.
genetics_overexpression_promote	34540669	hsa-mir-122	Rectal Neoplasms	Besides, overexpression of miR
genetics_overexpression_promote	34540669	hsa-mir-142	Rectal Neoplasms	Besides, overexpression of miR
lncRNA target	34540665	hsa-mir-1236	Colonic Neoplasms	3p functions as a tumor suppressor in colon cancer by targeting DCLK3 and is therefore a promising therapeutic target for colon cancer.
other	34540610	hsa-mir-26b	Capsule Opacification	RESULTS: The expression levels of miR-26b were significantly reduced in human posterior capsular opacification-attached lens tissue and TGF-beta2-stimulated HLE-B3 cells.
other	34540103	hsa-mir-153	Uterine Cervical Neoplasms	Significantly lower levels of miR-153 and miR-203 were found in patients with myometrial infiltration, FIGO III-IV stage, and lymphatic metastasis (P<0.05).
other	34540103	hsa-mir-203	Uterine Cervical Neoplasms	CONCLUSION: The expressions of miR-152 and miR-203 are down-regulated in patients with CC, which has diagnostic value for CC.
other	34540088	hsa-mir-92a	Colonic Neoplasms	CONCLUSION: Abnormally high expression of miR-92a occurs in colon tumor tissues.
circulation_biomarker_diagnosis_ns	34540082	hsa-mir-214	Osteoarthritis, Knee	PURPOSE: To explore the effect of Etoricoxib on serum miR-214 expression level and inflammatory reaction in patients with knee osteoarthritis.
other	34540060	hsa-mir-506	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	miR-506 is evidently reduced in CML, and may be applied as a diagnostic and predictive treatment for CML and 5-year related survival
circulation_biomarker_prognosis_up	34540055	hsa-mir-192	Colonic Neoplasms	The present study analyzed serum miR
circulation_biomarker_diagnosis_ns	34540038	hsa-mir-205	Chronic Periodontitis	An ROC curve analysis showed that the areas under the curve (AUCs) of the serum miR-205 and HMGB1 expressions in diagnosing PO were 0.936 and 0.955 respectively.
lncRNA target	34540003	hsa-mir-106b	late onset Parkinson's disease	CONCLUSION: LncRNA PART1 could alleviate the damage effects of MPP(+) on SH-SY5Y cells by regulating microRNA-106b-5p/MCL1 axis, suggesting the potential therapeutic value of LncRNA PART1 as a target in PD.
other	34540002	hsa-mir-27a	Alzheimer Disease	LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro-27a-3p.
lncRNA target	34539997	hsa-mir-32	Diabetes Mellitus	3p, thus inhibiting PCOS and diabetes progression.
lncRNA target	34539997	hsa-mir-32	Polycystic Ovary Syndrome	3p, thus inhibiting PCOS and diabetes progression.
circulation_biomarker_diagnosis_up	34539994	hsa-mir-579	Multiple Myeloma	3p-inhibitor plasmids compared with the blank group (P>0.050).
transcription factor target	34539990	hsa-mir-590	Osteoarthritis	CONCLUSIONS: miR5p promotes OA progression by targeting FGF18, which serves as a potential therapeutic target for OA.
circRNA target	34539989	hsa-mir-622	Anodontia	CircUBXN7 suppressed cell apoptosis and inflammatory reaction induced by H/R via targeting miR-622. CONCLUSION: CircUBXN7 mitigates cardiomyocyte apoptosis and inflammatory reaction in H/R injury by targeting miR-622 and maintaining MCL1 expression.
target gene	34539985	hsa-mir-761	Carcinoma, Non-Small-Cell Lung	LncRNA TPTEP1 inhibited the proliferation and metastasis of non-small cell lung cancer cells by targeting miR-761/LATS2 axis.
other	34539984	hsa-mir-206	Stomach Neoplasms	FAM225A-miR-206-ADAM12 axis may be a potential pathway for regulating gastric cancer.
target gene	34539888	hsa-mir-365a	Colorectal Neoplasms	Inhibition of the cell migration, invasion and chemoresistance of colorectal cancer cells through targeting KLF3 by miR-365a-3p.
target gene	34539887	hsa-mir-133a	Colorectal Neoplasms	FOXD3-induced miR-133a blocks progression and metastasis of colorectal cancer through regulating UBA2.
target gene	34539882	hsa-mir-552	Uterine Cervical Neoplasms	miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway.
lncRNA target	34539879	hsa-mir-455	Cholangiocarcinoma	Inhibition of miR
other	34539877	hsa-mir-23a	Hepatoblastoma	Conclusion: We concluded that SNHG9/miR-23a-5p/Wnt3a axis promotes the progression hepatoblastoma tumor.
lncRNA target	34539867	hsa-mir-545	Osteosarcoma	5p functions as a tumor suppressor in osteosarcoma that promotes apoptosis, while inhibiting migration and invasion by targeting DIMT1.
genetics_overexpression_promote	34539866	hsa-mir-1	Endometrial Neoplasms	Furthermore, circ_POLA2 overexpression also increased EC cell proliferation, while miR-31 overexpression decreased cell proliferation.
genetics_knock down_promote	34539861	hsa-mir-149	Osteosarcoma	Knockdown of lncRNA C5orf66-AS1 inhibits osteosarcoma cell proliferation and invasion via miR-149-5p upregulation.
other	34539857	hsa-mir-630	Lymphoma, Large B-Cell, Diffuse	5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05).
other	34539857	hsa-mir-19b	Lymphoma, Large B-Cell, Diffuse	5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05).
other	34539857	hsa-mir-370	Lymphoma, Large B-Cell, Diffuse	5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05).
other	34539857	hsa-mir-193a	Lymphoma, Large B-Cell, Diffuse	5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05).
other	34539857	hsa-mir-490	Lymphoma, Large B-Cell, Diffuse	5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05).
other	34539857	hsa-mir-665	Lymphoma, Large B-Cell, Diffuse	5p, miR-630 and miR-665) using DLBCL and LRH fresh samples.
target gene	34539856	hsa-mir-382	Osteosarcoma	MicroRNA-382-5p inhibits osteosarcoma development and progression by negatively regulating VEZF1 expression.
lncRNA target	34539855	hsa-mir-143	Carcinoma, Non-Small-Cell Lung	3p in LUSC, and thus may become a potential prognostic marker and therapeutic target for the treatment of LUSC in the future.
transcription factor target	34539847	hsa-mir-139	Endometriosis	5p may play a key role in the progression of endometriosis by regulating the viability of ESCs and directly targeting BBC3.
target gene	34539845	hsa-mir-140	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Salidroside inhibits chronic myeloid leukemia cell proliferation and induces apoptosis by regulating the miR-140-5p/wnt5a/β-catenin axis.
other	34539843	hsa-mir-424	Osteoarthritis	In summary, the findings indicated that LINC00473 contributed to OA progression by modulating the miR5p/LY6E axis, which may serve as a potential therapeutic strategy for patients with OA.
genetics_knock down_suppress	34539840	hsa-mir-140	Osteoarthritis	LINC01385 knockdown reduced the progression of OA by modulating the miR
genetics_knock down_suppress	34539833	hsa-mir-155	Ovarian Neoplasms	5p inhibition or TYRP1 overexpression markedly reversed the inhibitory effects of miR155HG knockdown on OC cell viability, migration and invasion as well as weakened the promotive effect of miR155HG knockdown on OC cell apoptosis.
lncRNA target	34539825	hsa-mir-138	Asthma	The TUG1/miR5p/E2F3 regulatory axis appeared to play a critical role in accelerating the viability and migration of ASMCs and may therefore have a role in asthma.
target gene	34539824	hsa-mir-532	Uterine Cervical Neoplasms	LINC01094 promotes the invasion of ovarian cancer cells and regulates the Wnt/β-catenin signaling pathway by targeting miR-532-3p.
genetics_overexpression_promote	34539823	hsa-mir-27a	Arthritis, Rheumatoid	Silencing TLR5 in RASFs may exert similar effects to miR-27a-3p-overexpression; whereas, restoring TLR5 counteracted the suppression of miR-27a-3p-overexpression on RASF proliferation and inflammation, as well as the promotion on apoptosis. miR-27a-3p upregulation may suppress RA progression by inhibiting RASFs proliferation and inflammation through targeting TLR5.
circRNA target	34539405	hsa-mir-4778	Arthritis, Rheumatoid	The level of the miRNA target of circ_0005198, miR
circulation_biomarker_diagnosis_ns	34539341	hsa-let-7g	Ischemic Stroke	These data suggest that circulating mml-let-7g may serve as a therapeutic target for ischemic stroke.
genetics_overexpression_promote	34538046	hsa-mir-877	Prostatic Neoplasms	5p, while overexpression of SSFA2 could abrogate the anti-tumor effects of miR
other	34537908	hsa-mir-17	dystonia 5	These findings indicate that PDE can activate GR in fetal rat ovary and induce DOR of offspring, and its heritability is mediated by the cascade effect of miR5p/FOXL2/CDKN1B.
transcription factor target	34537818	hsa-mir-2337	Infertility	Taken together, our findings identify miR-2337 as an endogenous small activating RNA (saRNA) of TGF-beta1 in GCs, while miR-2337 is identified as a small activator of the TGF-beta signaling pathway which is expected to be a new target for rescuing GC apoptosis and treating low fertility.
other	34537762	hsa-mir-22	Multiple Sclerosis	Patients with SPMS have a significantly higher miRNA-22 level than patients with RRMS.
genetics_overexpression_suppress	34537760	hsa-mir-320d	Prostatic Neoplasms	Further, a recovery experiment was used to confirm that miR-320d inhibited the progression of prostate cancer. KIF3C was overexpressed in prostate cancer, promoting its growth migration and invasion was induced by miR-320d/METTL3 in an m6A dependent process.
circRNA target	34537436	hsa-mir-4726	Intervertebral Disc Degeneration	The tension-sensitive circRNA_0022382 was decreased, and we found that circRNA_0022382 promoted morphology of endplate chondrocytes by sponge-binding miR5p down-regulation of target gene the TGF-beta3 expression, thereby alleviating IDD.
exosome	34537206	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	We found that exosomal miR
genetics_overexpression_promote	34537072	hsa-mir-493	Carcinoma, Non-Small-Cell Lung	Overexpression of miR
circulation_biomarker_diagnosis_up	34537058	hsa-mir-135	Stomach Neoplasms	CONCLUSION: There are high expression levels of serum miR-135 and miR-20a in patients with GC.
circulation_biomarker_diagnosis_up	34537058	hsa-mir-20a	Stomach Neoplasms	CONCLUSION: There are high expression levels of serum miR-135 and miR-20a in patients with GC.
lncRNA target	34536977	hsa-mir-515	Glioblastoma	CONCLUSION: LncRNA DLGAP1-AS1 accelerated cell proliferation in GBM via targeting miR
circulation_biomarker_diagnosis_ns	34536749	hsa-mir-125b	Myelodysplastic Syndromes	We apply the assay to the detection of miRNAs related to myelodysplastic syndromes (miR-125b, miR-16) in blood plasma and demonstrate that the assay enables detection of miR-125b with a limit of detection (LOD) of 349 aM (corresponding to the lowest detectable amounts of 419 zmol).
circulation_biomarker_diagnosis_ns	34536749	hsa-mir-16	Myelodysplastic Syndromes	We apply the assay to the detection of miRNAs related to myelodysplastic syndromes (miR-125b, miR-16) in blood plasma and demonstrate that the assay enables detection of miR-125b with a limit of detection (LOD) of 349 aM (corresponding to the lowest detectable amounts of 419 zmol).
exosome	34536574	hsa-mir-149	Lissencephaly	CONCLUSION: Exosome-mediated transfer of circ_0001846 modulated IL-1beta-induced chondrocyte cell damage by miR
exosome	34536574	hsa-mir-149	Osteoarthritis	CONCLUSION: Exosome-mediated transfer of circ_0001846 modulated IL-1beta-induced chondrocyte cell damage by miR
other	34536542	hsa-mir-181a	Myocardial Ischemia	In addition, treatment with 5-Aza enhanced ischemia and reperfusion-induced cardiac dysfunction and injury in adults as compared with the saline controls, which was associated with up-regulations of miRNA-181a and angiotensin II receptor type 1 & 2 gene expressions, but down-regulations of PKCepsilon, Atg5, and GSK3beta gene expressions in left ventricles.
genetics_overexpression_suppress	34536429	hsa-mir-132	Alzheimer Disease	Lentiviral-mediated inhibition or overexpression of miR
other	34536193	hsa-mir-182	Paraganglioma	RESULTS: Our computational analysis identified four candidate miRNAs that showed elevated expression in metastatic compared to non-metastatic PCPGs: miR-182, miR-183, miR-96, and miR-383. Finally, using univariate and multivariate analysis, we found miRNA miR-182 to be an independent predictor of metastasis-free survival in PCPGs.
other	34536193	hsa-mir-182	Pheochromocytoma	RESULTS: Our computational analysis identified four candidate miRNAs that showed elevated expression in metastatic compared to non-metastatic PCPGs: miR-182, miR-183, miR-96, and miR-383. Finally, using univariate and multivariate analysis, we found miRNA miR-182 to be an independent predictor of metastasis-free survival in PCPGs.
circulation_biomarker_prognosis_up	34535770	hsa-mir-151a	Stomach Neoplasms	sEV-miR-151a-3p is highly expressed in GC-LM patients' plasma and presents poor prognosis.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-16	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-17	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-24	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-21	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-23b	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
circulation_biomarker_diagnosis_ns	34535708	hsa-mir-181a	Head and Neck Neoplasms	Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes.
genetics_overexpression_promote	34535152	hsa-mir-485	Colorectal Neoplasms	5p overexpression suppressed CRC cell proliferation, migration, and invasion and facilitated apoptosis.
other	34535085	hsa-mir-1278	Nephritis	CONCLUSIONS: The study indicates that circ_0007059 protects RMCs against apoptosis and inflammation during nephritis by attenuating miR-1278/SHP-1/STAT3 signaling.
circRNA target	34533810	hsa-mir-148b	Carcinoma, Basal Cell, Skin	CONCLUSIONS: Circ_NCKAP1 can promote skin BCC progression by sponging the miR-148b-5p/HSP90 axis, and circ_NCKAP1 may be a potential target for skin BCC therapy.
genetics_overexpression_promote	34533429	hsa-mir-132	Acute Lung Injury	Moreover, overexpression of miR
other	34533283	hsa-mir-132	Cardiac Complexes, Premature	We further demonstrated PSyC was mediated by EVs containing miR-132.
lncRNA target	34533201	hsa-mir-378a	Esophageal Squamous Cell Carcinoma	Taken together, these findings suggest that LINC00514 may participate in ESCC lipogenesis, and targeting the LINC00514/miR378a5p/SPHK1 signaling axis may be a novel and promising therapeutic strategy for management of patients with ESCC.
transcription factor target	34533066	hsa-mir-128	Carcinoma, Non-Small-Cell Lung	Conclusion:miR3p inhibited the progression of NSCLC through targeting SKA3.
genetics_overexpression_promote	34533029	hsa-mir-10a	Colonic Neoplasms	The conditioned medium (CM) from LX-2 cells with miR-10a-5p overexpression or HLNFs could inhibit the invasion, migration, and stemness of CC SW480 cells, whereas HLCFs CM could promote these malignant phenotypes of SW480 cells.
circulation_biomarker_diagnosis_up	34533019	hsa-mir-379	Muscular Dystrophy, Duchenne	We identified the upregulation of miR-379 in the serum and muscles of DMD animal models and patients.
circulation_biomarker_diagnosis_up	34533019	hsa-mir-379	Diabetic Nephropathies	We identified the upregulation of miR-379 in the serum and muscles of DMD animal models and patients.
lncRNA target	34532814	hsa-mir-423	Diabetic Nephropathies	Taken together, XIST depletion suppressed proliferation and promoted apoptosis via miR
genetics_overexpression_promote	34532813	hsa-mir-432	Osteosarcoma	Circ_0000376 overexpression-mediated protective effects in Tan I-induced OS cells were partly attenuated by the accumulation of miR
lncRNA target	34532486	hsa-mir-93	Sciatic Neuropathy	5p can be used as potential targets for the diagnosis and treatment of sciatic nerve injury.
circRNA target	34532485	hsa-mir-515	Polycystic Ovary Syndrome	CONCLUSIONS: circRHBG inhibits ferroptosis in PCOS cells through the circRHBG/miR5p/SLC7A11 axis in PCOS, which may provide new diagnostic molecular markers and therapeutic targets for PCOS.
other	34532478	hsa-mir-1238	Colorectal Neoplasms	MMP1/MMP2/MMP9 axis in the growth and metastasis of CRC, which is crucial for the monitoring and treatment of CRC.
exosome	34532460	hsa-mir-21	Myocardial Reperfusion Injury	CONCLUSIONS: MSC-EXOs promote the polarization of macrophages to the M2 phenotype via miR
lncRNA target	34532436	hsa-mir-146a	Acute Lung Injury	Together, in vivo and in vitro results demonstrated that CHRF enhanced sepsis-induced ALI by targeting miR-146a and up-regulating Notch1.
transcription factor target	34532435	hsa-mir-218	Adenocarcinoma of Lung	CONCLUSIONS: miR-218 may negatively regulate FANCI, and FANCI could promote metastasis via extracellular matrix (ECM) receptor interaction, leading to poor prognosis of LUAD.
genetics_overexpression_suppress	34532392	hsa-mir-1278	Carcinoma, Non-Small-Cell Lung	Overexpression of circ_0015278 attenuated the malignant phenotypes of NSCLC through sponging miR-1278 and consequently promoting SOCS6 expression.
circRNA target	34532379	hsa-mir-361	Osteosarcoma	CONCLUSIONS: hsa_circ_0000006 is associated with the progression and development of OS through miR
lncRNA target	34532373	hsa-mir-197	Triple Negative Breast Neoplasms	A mimic and an inhibitor of miR
other	34532322	hsa-mir-4732	Myocardial Infarction	Overall, these results indicate that miR3p is regulated by hypoxia and exerts cardioprotective actions against ischemic insult, with potential application in cell-free-based therapeutic strategies.
circulation_biomarker_prognosis_up	34532291	hsa-mir-199b	Stomach Neoplasms	The expression of miR-199b-5p in GC cells and patients' plasma was detected by RT-PCR.
lncRNA target	34532283	hsa-mir-9	Glioma	5p directly targets ABCC1 and may make glioma cells sensitive to TMZ.
genetics_knock down_promote	34532282	hsa-mir-4435-2	Stomach Neoplasms	The knockout of MIR4435-2HG could repress the proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) and accelerate the apoptosis of gastric carcinoma cells.
genetics_overexpression_promote	34532130	hsa-mir-744	Carcinoma, Hepatocellular	Further, the overexpression of TGF-beta1 appeared to abolish the inhibitive effect of miR
lncRNA target	34532100	hsa-mir-204	Stomach Neoplasms	In addition, circNOP10 sponged microRNA-24 (miR-204)-mediated biological processes through sirtuin 1 (SIRT1), which further confirmed that the circNOP10/miR-204/SIRT1 pathway promoted proliferation and migration as well as epithelial-mesenchymal transition (EMT) through the NF-kappabeta pathway in GC cell lines. CONCLUSIONS: Candidate oncogene circNOP10 mediated GC cell proliferation, arrest cell cycle in G(2)/M phase, induced cell apoptosis, enhanced tumor metastasis, as well as EMT by activating the miR-204/SIRT1 pathway, suggesting that it may serve as a potential biomarker in GC therapy.
transcription factor target	34532027	hsa-mir-140	Diabetes Mellitus	Dan improved diabetes mellitus-induced renal injury via regulation of miR5p/TLR4 axis in in vitro and in vivo study.
transcription factor target	34532027	hsa-mir-140	Kidney Diseases	Dan improved diabetes mellitus-induced renal injury via regulation of miR5p/TLR4 axis in in vitro and in vivo study.
target gene	34531986	hsa-mir-1254	Uterine Cervical Neoplasms	lncRNA FEZF1-AS1 regulates biological behaviors of cervical cancer by targeting miRNA-1254.
target gene	34531985	hsa-mir-145	Stomach Neoplasms	Muscone suppresses gastric cancer via regulation of miRNA-145.
lncRNA target	34531932	hsa-mir-10b	Breast Neoplasms	BACKGROUND: In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. In addition, we evaluated the uptake of (64)Cu-MN-anti-miR10b by metastatic lesions using both in vivo and ex vivo positron emission tomography-magnetic resonance imaging (PET-MRI).
lncRNA target	34531932	hsa-mir-10b	Neoplasm Metastasis	BACKGROUND: In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. In addition, we evaluated the uptake of (64)Cu-MN-anti-miR10b by metastatic lesions using both in vivo and ex vivo positron emission tomography-magnetic resonance imaging (PET-MRI).
target gene	34531912	hsa-mir-200b	Stomach Neoplasms	MiR-200b Suppresses Gastric Cancer Cell Migration and Invasion by Inhibiting NRG1 through ERBB2/ERBB3 Signaling.
target gene	34531664	hsa-mir-34c	Lung Neoplasms	CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p.
transcription factor target	34531509	hsa-mir-338	Intervertebral Disc Degeneration	3p as a mediator of IDD and thus may be a promising target for rescuing IDD.
genetics_GWAS	34531437	hsa-mir-22	Thyroid Nodule	3p/CBL axis was established to explain the effect of SNP of circ-ITCH in thyroid tumor malignancy.
genetics_knock down_promote	34531378	hsa-mir-139	Liver Cirrhosis	5p overexpression alleviated murine liver fibrosis.
circRNA target	34530825	hsa-mir-107	Esophageal Squamous Cell Carcinoma	SLC1A5 was a target of miR-107, and it worked as an oncogene in EC cells.
target gene	34530822	hsa-mir-550a	Lung Neoplasms	MicroRNA-550a-3-5p controls the brain metastasis of lung cancer by directly targeting YAP1.
lncRNA target	34530821	hsa-mir-613	Thyroid Cancer, Papillary	CONCLUSION: Our findings demonstrated that miR-613 can suppress the progression of PTC cells by targeting TAGLN2, indicating that miR-613 plays the role of a tumor suppressor in PTC.
other	34530741	hsa-mir-146b	Coronary Artery Disease	CONCLUSION: hsa-miR5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD.
other	34530741	hsa-mir-361	Coronary Artery Disease	CONCLUSION: hsa-miR5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD.
other	34530722	hsa-mir-92a	Thrombosis	BACKGROUND: MiR-92a-3p and oxidative stress are associated with catheter-related thrombosis (CRT).
circulation_biomarker_diagnosis_up	34530722	hsa-mir-92a	Colorectal Neoplasms	In the CRT RE group, after administering the resistance exercise intervention, ROS production and MDA activity in serum significantly decreased, the expression level of HO-1 increased and the expression level of miR-92a-3p in the venous tissues significantly decreased and was negatively correlated with that of HO-1.
other	34530722	hsa-mir-92a	Upper Extremity Deep Vein Thrombosis	BACKGROUND: MiR-92a-3p and oxidative stress are associated with catheter-related thrombosis (CRT).
other	34530424	hsa-mir-7a	Bone Diseases	The results may shed light on application of miR-7a-5p and miR-592 for maintaining osteo-differentiation potential in stem cells for bone regeneration and bone-related disease treatment.
other	34530424	hsa-mir-592	Bone Diseases	The results may shed light on application of miR-7a-5p and miR-592 for maintaining osteo-differentiation potential in stem cells for bone regeneration and bone-related disease treatment.
genetics_overexpression_promote	34530115	hsa-mir-363	Glioblastoma	3p depletion or overexpression of NOB1.
lncRNA target	34529965	hsa-let-7f	Vascular Diseases	Herein, we investigated the functions of microRNA let-7f (also termed let-7f-5p) in vascular endothelial cell dysfunction. In conclusion, let-7f alleviates vascular endothelial cell dysfunction by downregulating HMGA2 expression under OGD/R.
other	34528912	hsa-mir-661	Carcinoma, Non-Small-Cell Lung	Hsa_circ_0001947 acts as a sponge of miR-661 to repress NSCLC development by elevating the expression of DOK7.
lncRNA target	34528899	hsa-mir-497	Myocardial Infarction	This study provides novel potential therapeutic thought for the prevention and treatment of MI through targeting miR-497/Smad7.
lncRNA target	34528899	hsa-mir-497	Heart Diseases	Some microRNAs (miRNAs) including miR-497 and related target genes have been proved to be closely linked with heart diseases.
lncRNA target	34528899	hsa-mir-497	Heart Injuries	CONCLUSIONS: We found that EVs isolated from MSCs might improve the cardiac injury caused by MI through targeting miR497/Smad7.
other	34528842	hsa-mir-122	Chemical and Drug Induced Liver Injury	Introduction: MicroRNA-122 (miR-122) is a novel biomarker of liver injury and has been proposed as an early predictor of acetaminophen-associated hepatotoxicity.
other	34528556	hsa-mir-145	Endometrial Neoplasms	miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors.
other	34528556	hsa-mir-145	Endometriosis	miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors.
other	34528556	hsa-mir-145	Carcinoma, Endometrioid	miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors.
lncRNA target	34528480	hsa-mir-149	Noonan syndrome-like disorder with loose anagen hair	Our data suggest that miR-149 is involved in the etiology of nsCL/P via its role in hNCC migration.
lncRNA target	34528480	hsa-mir-149	Lesch-Nyhan Syndrome	Our data suggest that miR-149 is involved in the etiology of nsCL/P via its role in hNCC migration.
circRNA target	34528447	hsa-mir-224	Inflammatory Bowel Diseases	Conclusion: Hsa_circ_0001021 is related to UC severity and regulates epithelial barrier function via sponging miR5p.
other	34528314	hsa-mir-339	Breast Neoplasms	5p in BC tumor compared to corresponding adjacent tissues.
other	34528314	hsa-mir-335	Breast Neoplasms	5p in BC tumor compared to corresponding adjacent tissues.
circulation_biomarker_diagnosis_up	34528223	hsa-mir-129	Non-alcoholic Fatty Liver Disease	Serum miR
genetics_knock down_suppress	34528144	hsa-mir-643	Squamous Cell Carcinoma of Head and Neck	MiR-643 overexpression had an inhibition effect on OSCC progression, and its inhibitor could reverse the negative regulation of circLPAR3 knockdown on OSCC progression.
therapeutic target	34527562	hsa-mir-516b	Thyroid Cancer, Papillary	This study verified the novel function of the circRAD18-miR-516b-PDK1 axis in papillary thyroid cancer metabolic reprogramming progression, which has potential to be a novel therapeutic target.
transcription factor target	34527345	hsa-mir-204	Aortic Valve Insufficiency	CONCLUSIONS: Regulated by miRNA3p, CXCR4 could inhibit the progression of AR after HTx.
circulation_biomarker_diagnosis_ns	34527338	hsa-mir-122	Essential Hypertension	The purpose of our research was to investigate the correlation between serum miR-122 and myocardial damage and ventricular functions in EH patients. CONCLUSIONS: The serum miR-122 concentration in EH patients was higher than that in healthy individuals, and miR-122 concentration was positively correlated with myocardial damage markers.
target gene	34527128	hsa-mir-367	Carcinoma, Non-Small-Cell Lung	Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer.
lncRNA target	34527075	hsa-mir-190a	Glioma	miR-190a-3p was expected to be a new target for molecular therapy of glioma.
other	34526802	hsa-mir-940	Cardiomyopathies	CONCLUSION: The downregulation of miR-940 was reported and it might be an underlying diagnostic marker in sepsis patients.
other	34526802	hsa-mir-940	Sepsis	CONCLUSION: The downregulation of miR-940 was reported and it might be an underlying diagnostic marker in sepsis patients.
transcription factor target	34526481	hsa-mir-206	Myocardial Reperfusion Injury	Coherently, HDAC4 silencing could up-regulate the expression of miR-206 to reduce cardiomyocyte apoptosis and inhibit oxidative stress, and exerting a protective effect on MIRI via the MEKK1/JNK pathway.
lncRNA target	34526098	hsa-mir-1236	Cholangiocarcinoma	CONCLUSIONS: CircHMGCS1-016 is a forceful contributor in ICC development and immune tolerance via miR
transcription factor target	34525985	hsa-mir-22	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-122	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-1	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-9	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-23b	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-19a	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
transcription factor target	34525985	hsa-mir-206	Asthma	This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b).
lncRNA target	34525952	hsa-mir-182	Prostatic Neoplasms	These findings show that miR-182 is highly expressed in AA patients and miR-182 may be a target for effective therapy in AA patients.
other	34525946	hsa-mir-200c	Angelman Syndrome	However, the functional role of miR-200c-3p in AS remains largely unknown. Here, we demonstrated the critical role of miR-200c-3p in regulating EndMT in AS.
transcription factor target	34525477	hsa-mir-590	Periodontitis	Collectively, EVs carried miR3p into macrophages to subsequently inhibit TLR4 transcription, thereby reducing macrophage pyroptosis and alleviating periodontal inflammatory injury.
transcription factor target	34525477	hsa-mir-590	Periodontal Diseases	Collectively, EVs carried miR3p into macrophages to subsequently inhibit TLR4 transcription, thereby reducing macrophage pyroptosis and alleviating periodontal inflammatory injury.
other	34525476	hsa-mir-1298	Carcinoma, Non-Small-Cell Lung	lncRNA OSER1-AS1 had a higher diagnostic value in patients with NSCLC than miR5p and CHSY3.
lncRNA target	34524611	hsa-mir-200c	Stomach Neoplasms	In addition, down-regulation of miR-200c-3p suppressed cell viability, proliferation, migration, and invasion in GCC cells.
circRNA target	34524572	hsa-mir-21	Emphysema	These results demonstrated that, in alveolar epithelial cells, CS decreases circRNA_0026344 levels, which sponge miR-21 to inhibit the miR-21 target, PTEN, which, in turn, activates ERK and thereby promotes autophagy and apoptosis, leading to emphysema. Thus, for emphysema, circRNA_0026344 regulates the PTEN/ERK axis by sponging miR-21, which is associated with the CS-induced autophagy and apoptosis of alveolar epithelial cells.
circulation_biomarker_diagnosis_up	34524260	hsa-mir-125b	Myocardial Infarction	T-qPCRs were performed to measure the expression levels of MFACR and miR-125b in plasma samples from both MI patients (n = 61) and healthy controls (n = 61). We found that MFACR was upregulated in MI and inversely correlated with miR-125b.
genetics_overexpression_promote	34523750	hsa-mir-21	Glioma	3p overexpression, cell viability and apoptosis of glioma cell lines treated with FXT (50 mumol/L) were tested again.
lncRNA target	34523739	hsa-mir-487a	Carcinoma, Non-Small-Cell Lung	Retraction: 'Downregulation of miR-487a-3p suppresses the progression of non-small cell lung cancer via targeting Smad7' by Fan Y, Hao J, Cen X, Song K, Yang C, Xiao S, Cheng S, Drug Development Research.
other	34523694	hsa-mir-31	Pre-Eclampsia	Mechanistically, it was concluded that hsa_circ_0026552 acts as a miR3313p sponge to upregulate TGFbetaR1 expression in trophoblasts and is involved significantly in PE development and progression in pregnant women.
lncRNA target	34523356	hsa-mir-20b	Colorectal Neoplasms	Results:HCG18 and PD-L1 were upregulated while miR-20b-5p was downregulated in CRC tissue. Functional analysis revealed that lncRNA HCG18 promoted proliferation, migration and resistance to cetuximab of CRC cells via the miR-20b-5p/PD-L1 axis.
other	34523052	hsa-mir-132	Neonatal Sepsis	3p.
genetics_overexpression_promote	34522457	hsa-mir-374b	Pancreatic Carcinoma	In vitro assays indicated that overexpression of miR-374b-5p suppressed the proliferation, migration, and invasion of PC cells.
target gene	34522453	hsa-mir-506	Pancreatic Neoplasms	Downregulation of NEAT1 sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine through modulation of the miR-506-3p/ZEB2/EMT axis.
exosome	34522205	hsa-mir-21	Fibrosis, Renal	Conclusion: Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.
exosome	34522205	hsa-mir-21	Kidney Diseases	Conclusion: Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.
genetics_overexpression_promote	34522182	hsa-mir-139	Carcinoma, Hepatocellular	5p, CCT5 was overexpressed in HCC tumor tissues and peripheral blood mononuclear cells (all P < 0.05).
circRNA target	34522177	hsa-mir-616	Endometriosis	These results demonstrated that the downregulation of circ_0000673 could promote the progression of endometriosis by inactivating PTEN via the deregulation of miR3p.
other	34522168	hsa-mir-125a	Pulmonary Fibrosis	The miRNAs including miR-199b-5p, miR5p, miR-199a-5p, miR-125A-5p, and miR-107 that we predicted would regulate the VEGFA, CDH5, and WNT3A genes, which were also associated with IPF or other fibrosis-related diseases.
genetics_knock down_promote	34522027	hsa-mir-130a	Uveal melanoma	Taken together, overexpressed miR-130a inhibited USP6 expression to repress UM cell migration and invasion abilities through inactivating the Wnt/beta-catenin signaling pathway, which could be a potential candidate for treatment of UM.
lncRNA target	34521449	hsa-mir-497	Liver Cirrhosis	Furthermore, miR-497 inhibitor delivered by highly-hepatotropic (rAAV8) inhibited TGF-beta/smads signaling pathway by targeting at Smad7 to ameliorate CCL4-induced liver fibrosis. CONCLUSIONS: The present study demonstrates that miR-497 promotes liver fibrogenesis by targeting Smad7 to promote TGF-beta/Smad signaling pathway transduction both in vivo and in vitro, which provides a promising therapeutic strategy using anti-miR-497 against liver fibrosis.
exosome	34521413	hsa-mir-449a	Carcinoma, Non-Small-Cell Lung	Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer.
lncRNA target	34521353	hsa-mir-24	Ischemic Stroke	CONCLUSION: This study presents that depleting SOX2 improves IS via PVT1/miR
other	34520874	hsa-mir-622	Sepsis	MiR-519c-5p, miR-3622b-3p were novel biomarkers for diagnosing septic patients.
other	34520874	hsa-mir-519c	Sepsis	MiR-519c-5p, miR-3622b-3p were novel biomarkers for diagnosing septic patients.
genetics_overexpression_promote	34520626	hsa-mir-19b	Colorectal Neoplasms	It was found that miR-19b was overexpressed in CRC tissues, which indicated a poor prognosis.
lncRNA target	34520391	hsa-mir-378b	Glioma	The inhibition of miR-378b or the enhancement of SLC2A1 reversed ZNF609 depletion-regulated glioma cell proliferation in vitro.
genetics_knock down_suppress	34520298	hsa-mir-342	Carcinoma, Non-Small-Cell Lung	The overexpression of microRNA
other	34520170	hsa-mir-34a	Obesity	We investigated if BBP altered miR-34a-5p, a key miRNA involved in obesity, and regulated its downstream pathway.
lncRNA target	34520102	hsa-mir-378a	Ovarian Neoplasms	GALNT3 was a target gene of miR-378a-3p in OC. Overall, PSMA3-AS1 promotes OC cell proliferation, migration, invasion, and xenograft tumor growth by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis.
genetics_knock down_promote	34519997	hsa-mir-937	Carcinoma, Hepatocellular	Overexpression of miR-937 promoted HCC cell ability of proliferation, migration, and invasiveness, while knockdown of miR-937 inhibited these cellular behaviors.
genetics_overexpression_promote	34519914	hsa-mir-29a	Sepsis	Overexpression of miR-29a or inhibition of E2F2 abrogated the suppressive effect of TTN-AS1 overexpression on myocardial injury. CONCLUSION: This study indicates TTN-AS1 attenuates sepsis-induced myocardial injury by regulating the miR-29a/E2F2 axis and sheds light on lncRNA-based treatment of sepsis-induced cardiomyopathy.
genetics_overexpression_promote	34519914	hsa-mir-29a	Myocardial Infarction	Overexpression of miR-29a or inhibition of E2F2 abrogated the suppressive effect of TTN-AS1 overexpression on myocardial injury. CONCLUSION: This study indicates TTN-AS1 attenuates sepsis-induced myocardial injury by regulating the miR-29a/E2F2 axis and sheds light on lncRNA-based treatment of sepsis-induced cardiomyopathy.
genetics_knock down_promote	34519634	hsa-mir-153	Carcinoma, Hepatocellular	In addition, knockdown of TWF1 inhibited DDP resistance of HCC cells, which was reversed by miR
other	34519627	hsa-mir-637	Atherosclerosis	In conclusion, circUSP36 regulated WNT4 to aggravate endothelial cell injury caused by ox-LDL by competitively binding to miR-637; this finding indicates circUSP36 to be a promising biomarker for the diagnosis and therapy of atherosclerosis.
genetics_overexpression_promote	34519373	hsa-mir-151a	Glioma	Further inhibition of miR-151a or overexpression of CENPB restored radioresistance of glioma cells.
lncRNA target	34519263	hsa-mir-486	Dehydration	5p and upregulating PIM1, which may be related to the inhibition of TGF-beta/Smad pathway.
transcription factor target	34519263	hsa-mir-486	Leukemia, Myeloid	Proviral integration site for Moloney murine leukemia virus 1 (PIM1) was verified to be targeted by miR5p.
other	34519258	hsa-mir-106b	Carcinoma, Non-Small-Cell Lung	In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression.
genetics_knock down_promote	34519257	hsa-mir-646	Acute Coronary Syndrome	The knockdown of miR-3646 could alleviate ACS by reversing inflammatory response.
exosome	34519129	hsa-mir-24	Pancreatic Carcinoma	To conclude, exosomal-mediated SNHG11 could regulate PC progression via miR3p/VEGFA axis.
genetics_GWAS	34518949	hsa-mir-522	Triple Negative Breast Neoplasms	Besides, functional studies in two triple-negative breast cancer cell lines showed that overexpression of miR-522 significantly promoted cell proliferation, migration, and invasion in vitro.
genetics_knock down_suppress	34518490	hsa-mir-182	Neurogenic Inflammation	However, the injection of miR5p antagomir significantly reversed the level of the NP behaviors and neuroinflammation caused by PCAT19 knockdown.
genetics_knock down_suppress	34518490	hsa-mir-182	Neuralgia	However, the injection of miR5p antagomir significantly reversed the level of the NP behaviors and neuroinflammation caused by PCAT19 knockdown.
genetics_overexpression_promote	34518486	hsa-mir-433	Glioma	3p and AJUBA, it was found that overexpressing AJUBA could attenuate the inhibitory effect of overexpressing miR
genetics_knock down_promote	34518485	hsa-mir-23a	Wilms Tumor	CONCLUSIONS: The cell viability, migration, and invasiveness of WT cells were repressed by MEG8 knockdown via targeting the miR-23a-3p/CRK axis.
lncRNA target	34518442	hsa-mir-28	Carcinoma, Renal Cell	3p-FAM193B loop could serve as a potential biomarker and therapeutic target for ccRCC.
lncRNA target	34518440	hsa-mir-942	Osteosarcoma	In conclusion, HCG11 is downregulated in OS, and restrains OS growth both in vitro and in vivo by raising p27 Kip1 expression via binding to miR5p and IGF2BP2.
other	34518132	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	OBJECTIVE: Evaluation of diagnostic accuracy of microRNA-21 (miR-21) in saliva and tumor tissue for presurgical assessment of lymph node metastasis in patients with oral squamous cell carcinoma (OSCC). CONCLUSIONS: miR-21 expression in saliva and tumor tissue of patients with OSCC showed high diagnostic accuracy for assessment of cervical lymph node metastasis.
other	34517910	hsa-mir-146a	Pre-Eclampsia	OBJECTIVE: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE). RESULTS: Compared with normal placental tissues, the placentae from PE patients showed higher miR-146a-5p expression and lower Wnt2 expression.
transcription factor target	34517822	hsa-mir-3	Lipid Metabolism Disorders	CONCLUSIONS: This study demonstrated the crucial roles played by the miR5p/ABCA1/CS axis in regulating cholesterol efflux, inflammation, apoptosis, and aging in VECs, and also suggested the axis as a target for managing lipid metabolism disorders.
transcription factor target	34517822	hsa-mir-3	Inflammation	CONCLUSIONS: This study demonstrated the crucial roles played by the miR5p/ABCA1/CS axis in regulating cholesterol efflux, inflammation, apoptosis, and aging in VECs, and also suggested the axis as a target for managing lipid metabolism disorders.
genetics_knock down_promote	34517790	hsa-mir-216a	Neuralgia	Functional rescue experiments manifested that the suppressive effect of circSMEK1 knockdown on NP was reversed by declined miR-216a-5p simultaneously.
lncRNA target	34517787	hsa-mir-338	Spinal Cord Injuries	Together, TUG1 silencing could alleviate the death in neurons and ASCI models via modulating the miR-338/BIK axis.
other	34517612	hsa-mir-141	Prostatic Neoplasms	Herein, for the first time, an electrochemical sensing platform based on atom transfer radical polymerization (ATRP) signal amplification strategy for ultrasensitive determination of the breast and prostate cancer marker miRNA-141 has been developed.
genetics_overexpression_promote	34516983	hsa-mir-503	Hyperglycemia	Taken together, these findings demonstrate that overexpression of hsa_circ_0022742 suppressed HG-induced endothelial dysfunction by targeting the miR
lncRNA target	34516362	hsa-mir-194	Esophageal Squamous Cell Carcinoma	Collectively, lncRNA KCNMB2-AS1 promotes ESCA development through targeting the miR3p/ PYGL axis, which might provide theoretical basis to explore novel biomarkers for ESCA treatment.
lncRNA target	34516355	hsa-mir-21	Polycystic Ovary Syndrome	The aim of the study was to assess microRNA-21 regulates granulosa cell apoptosis and proliferation in polycystic ovary syndrome through target toll-like receptor 8.
genetics_knock down_promote	34516354	hsa-mir-580	Leukemia, Myeloid, Acute	In conclusion, SATB1-AS1 knockdown promotes the sensitivity of AML cells by upregulating miR-580 and downregulating OAS2 through the GSK3beta/beta-catenin pathway, providing new insights into the function of SATB1-AS1 as a miRNA sponge in AML.
lncRNA target	34516353	hsa-mir-520h	Carcinoma, Hepatocellular	Our results showed that IGF2-AS expression was significantly down-regulated in HCC cells and tissues; lower IGF2-AS expression was significantly associated with poor prognosis of HCC patients; IGF2-AS over-expression inhibited the viability, colony formation, invasion, and migration, while promoted apoptosis in vitro, and inhibited HCC xenograft growth in vivo; IGF2-AS sponged microRNA-520h (miR-520h) to up-regulate IGF2-AS expression, and miR-520h over-expression or cyclin-dependent kinase inhibitor 1A (CDKN1A) silencing reversed IGF2-AS reduced aggressive behaviors of HCC cells. In conclusion, IGF2-AS is a tumor-suppressor in HCC, and lower IGF2-AS expression is associated with poor prognosis of HCC patients; IGF2-AS inhibits HCC oncogenesis and development by IGF2-AS/miR-520h/CDKN1A pathway.
lncRNA target	34516344	hsa-mir-451a	Nasopharyngeal Carcinoma	miR-451a suppresses CSE1L expression, thereby reducing proliferation, invasion, and migration and increasing apoptosis of NPC cells.
other	34516341	hsa-mir-129	Carcinoma, Renal Cell	Therefore, hsa_circ_0002024 was identified as a prognostic ceRNA that might sponge hsa_miR_129-5p to regulate ASF1B and affect RCC prognosis.
lncRNA target	34516335	hsa-mir-613	Esophageal Squamous Cell Carcinoma	Moreover, RMRP promoted the proliferation, migration, and invasion of ESCC cells via regulating miR-613/NRP2.RMRP was involved in the progression of ESCC through regulating the miR-613/NRP2 axis, which provides a potential target for the treatment of ESCC.
genetics_overexpression_promote	34516334	hsa-mir-495	Carcinoma, Hepatocellular	The in vivo experiment demonstrated miR-495 overexpression had great therapeutic effects on HCC in xenograft.
genetics_overexpression_suppress	34516333	hsa-mir-361	Carcinoma, Renal Cell	3p inhibitor or PGF overexpression could relieve the inhibitory effect of silencing ARAP1-AS1 on ccRCC cells.
genetics_overexpression_promote	34516330	hsa-mir-215	Stomach Neoplasms	3p overexpression counteracted the biological effects of PCED1B-AS1.
lncRNA target	34516316	hsa-mir-221	Pulmonary Disease, Chronic Obstructive	3p alleviated cell apoptosis and inflammatory response via targeting CDKN1B in an in vitro model of COPD.
lncRNA target	34516314	hsa-mir-198	Colorectal Neoplasms	Our findings identify circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC.
genetics_GWAS	34515927	hsa-mir-143	Schizophrenia	We aimed to investigate the link between rs4705342T/C and rs4705343T/C polymorphisms in the promoter region of miR-143 and the risk of schizophrenia (SCZ) in a sample of an Iranian population. The result of the bioinformatics analysis showed that miR-143, as a critical miRNA, targets ERK5, ERBB3, HK2, and PKCepsilon, the four major genes involved in SCZ development.
genetics_overexpression_promote	34515875	hsa-mir-375	Rectal Neoplasms	MiR-375 overexpression suppressed the malignant behaviors of rectal cancer cells partly through down-regulating ROCK1.
genetics_knock down_suppress	34515612	hsa-mir-337	Cardiomegaly	An adenovirus vector system was employed to knockdown miR
other	34515323	hsa-mir-532	Diabetes Mellitus	The expression of microRNA (miR)5325P is downregulated in diabetes, but its specific role in diabetes has not yet been elucidated. The present study aimed to investigate the specific mechanism underlying the effects of miR5325p on diabetes.
genetics_overexpression_promote	34515321	hsa-mir-218	Urinary Bladder Neoplasms	Furthermore, miR218 overexpression blocked the promoting effects of Rab6c on the malignant behavior of bladder cancer cells.
genetics_knock down_promote	34515320	hsa-mir-761	Colorectal Neoplasms	Collectively, the present results suggested that knockdown of PVT1 may inhibit the progression of CRC by regulating the miR761/MAPK1 axis, which may provide a promising biomarker for the treatment of CRC.
circulation_biomarker_diagnosis_ns	34515297	hsa-mir-19a	Myocardial Infarction	We found that DANCR expression and miR-19a-3p level are negatively correlated as DANCR expression is increased, while miR-19a-3p level is decreased in AMI patients' serum and OGD/R-exposed HL-1 cells.
genetics_overexpression_promote	34515239	hsa-mir-224	Carcinoma, Renal Cell	Overexpression of OCLN could reduce the proliferation, migration, and invasion of ccRCC cells, while overexpressed miR
other	34515193	hsa-mir-126	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	CONCLUSION The study concludes that expression of miR-126 and miR-122 increases after imatinib treatment in CML patients and that miR-126 defines the good responders of imatinib therapy.
other	34515180	hsa-mir-29a	Nervous System Diseases	Additionally, the repressive action of NGR1 in neurological impairment and neuroinflammation was eliminated by downregulating miR-29a in rats.
other	34515180	hsa-mir-29a	Parkinson Disease	Additionally, the repressive action of NGR1 in neurological impairment and neuroinflammation was eliminated by downregulating miR-29a in rats.
circulation_biomarker_diagnosis_down	34515176	hsa-mir-150	Parkinson Disease	5p was the target gene of RMST and less expressed in the clinical serum samples and PD cell models.
circulation_biomarker_diagnosis_up	34514705	hsa-mir-193b	Thyroid Neoplasms	TC cells were transfected with DLX6-AS1/miR-193b-3p-related oligonucleotides or plasmids to test cell growth and autophagy.
transcription factor target	34514658	hsa-mir-935	Sveinsson Chorioretinal Atrophy	Of these 4 miRs, miR-3935 stood out, as its predicted target PTGER3, the prostaglandin EP(3) receptor, was downregulated in treated AA patients compared with untreated.
transcription factor target	34514658	hsa-mir-935	Hypersensitivity	CONCLUSIONS: While profiling the sputum of allergic patients for novel miR expression patterns, we uncovered an association between miR-3935 and its predicted target gene, the prostaglandin E(3) receptor, which might mediate AIT effects through suppression of the PGE(2) -PTGER3 axis.
target gene	34514167	hsa-mir-496	Stomach Neoplasms	miR-496 inhibits proliferation via LYN and AKT pathway in gastric cancer.
genetics_knock down_promote	34514098	hsa-mir-26a	Stomach Neoplasms	Loc100506691 negatively regulated CHAC1 expression by modulating miR-26a-5p/miR-330-5p expression, and CHAC1 knockdown markedly attenuated Loc100506691 knockdown-induced gastric cancer cell growth and motility suppression.
genetics_knock down_promote	34514098	hsa-mir-30	Stomach Neoplasms	Loc100506691 negatively regulated CHAC1 expression by modulating miR-26a-5p/miR-330-5p expression, and CHAC1 knockdown markedly attenuated Loc100506691 knockdown-induced gastric cancer cell growth and motility suppression.
transcription factor target	34514096	hsa-mir-1207	Squamous Cell Carcinoma of Head and Neck	5p inhibited LSCC malignant progression by downregulating SKA3 and preventing EMT.
lncRNA target	34514002	hsa-mir-423	Carcinoma, Renal Cell	Next, our experiments found that circFOXP1 upregulated U2AF2 expression via sponging miR
transcription factor target	34513987	hsa-mir-137	Hypoxia	The present study found for the first time that miR-137 was downregulated in pulmonary arteries of hypoxic PH rats and in hypoxia-treated PASMCs. Our study demonstrated that hypoxia-induced downregulation of miR-137 expression promoted the proliferation of PASMCs by targeting calpain-2, thereby potentially resulting in pulmonary vascular remodeling in hypoxic PH.
transcription factor target	34513987	hsa-mir-137	Hypertension, Pulmonary	Our study demonstrated that hypoxia-induced downregulation of miR-137 expression promoted the proliferation of PASMCs by targeting calpain-2, thereby potentially resulting in pulmonary vascular remodeling in hypoxic PH.
transcription factor target	34513931	hsa-mir-223	Diabetic Keratopathy	5p suppression ameliorated inflammation and enhanced cell proliferation signaling in DK.
other	34513927	hsa-mir-126	Hind Limb Ischemia	The Effect of MicroRNA-126 Mimic Administration on Vascular Perfusion Recovery in an Animal Model of Hind Limb Ischemia. A statistically significant negative correlation was noted between microRNA-126 and VEGF tissue expression levels in the ischemic limbs of the entire study population.
circulation_biomarker_diagnosis_ns	34513856	hsa-mir-3	Niemann-Pick Diseases	Dietary cholesterol levels did not affect the microbiome and neither did alterations of plasma lipid levels through treatments of miR-33 antisense oligonucleotide (anti-miR-33), Niemann-Pick C1-Like 1 (NPC1L1) antisense oligonucleotide (ASO), and inducible degrader of LDLR (IDOL) ASO.
target gene	34513821	hsa-mir-124	Uterine Cervical Neoplasms	LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer.
exosome	34513819	hsa-mir-15b	Tendon Injuries	Taken together, the results show that M2 macrophage-derived circRNA-Ep400-containing exosomes promote peritendinous fibrosis after TI via the miR-15b-5p/FGF-1/7/9 pathway, which suggests novel therapeutics for tendon injury treatment.
transcription factor target	34513812	hsa-mir-100	Heart Failure	In conclusion, these results indicate that HucMSC-EVs inhibit DOX-induced heart failure through the miR5p/NOX4 pathway.
transcription factor target	34513803	hsa-mir-101	Intervertebral Disc Degeneration	3p inhibitor, the expressions of ECM-related proteins, cell viability, and apoptosis were detected.
lncRNA target	34513693	hsa-mir-214	Carcinoma, Hepatocellular	Rescue assays demonstrated that functions of LINC00882 deficiency in HCC cells were reversed through suppressing miR
other	34513660	hsa-mir-24	Adenocarcinoma of Lung	In the present study, qRT-PCR was used to measure the levels of GAS6-AS1, GIMAP6 and miR3p expression in LUAD samples and cell lines.
genetics_overexpression_promote	34513340	hsa-mir-140	Squamous Cell Carcinoma of Head and Neck	3p in LSCC was verified in the experiment, and it was proved that overexpression of miR
other	34513304	hsa-mir-382	Infertility	3p in pubertal Scs could be one of the underlying causes of idiopathic male infertility and should be considered for diagnosis and treatment of infertility.
other	34513304	hsa-mir-382	Infertility, Male	Hence, sustained high levels of miR3p in pubertal Scs could be one of the underlying causes of idiopathic male infertility and should be considered for diagnosis and treatment of infertility.
lncRNA target	34513303	hsa-mir-218	Diabetes Mellitus, Type 1	Importantly, miR-218 was found to be upregulated in DM1 muscle biopsies, pinpointing this microRNA (miRNA) as a relevant therapeutic target.
lncRNA target	34513301	hsa-mir-92a	Ischemic Stroke	Mechanistic analysis revealed that lncRNA XIST modulated angiogenesis and alleviated cerebral vascular injury following CIS through mediating the miR-92a/Itgalpha5 or KLF4 axis, respectively.
other	34513297	hsa-mir-432	Liver Neoplasms	circ-PRKAR1B/miR-432-5p/E2F3 signaling involved in liver cancer progression
lncRNA target	34513288	hsa-mir-586	Breast Neoplasms	Moreover, we demonstrated that LINC01189 functioned as a tumor suppressor and inhibited breast cancer progression through inhibiting an epithelial-mesenchymal transition (EMT)-like phenotype by sponging miR-586.
circulation_biomarker_diagnosis_ns	34512893	hsa-mir-129	Diabetic Angiopathies	CONCLUSION: Elevated serum miR
circulation_biomarker_diagnosis_ns	34512893	hsa-mir-129	Diabetes Mellitus	CONCLUSION: Elevated serum miR
other	34512861	hsa-mir-223	Kidney Calculi	Our results suggest that the lncRNA XIST participates in the formation and progression of renal calculus by interacting with miR3p and the NLRP3/Caspase-1/IL-1beta pathway to mediate the inflammatory response and ROS production.
target gene	34512774	hsa-mir-375	Uterine Cervical Neoplasms	miR-375 inhibits the malignant development of human cervical cancer cells by regulating the expression of YAP1.
circRNA target	34512755	hsa-mir-96	Pancreatic Carcinoma	5p/KRAS/MAPK signaling pathway and might be a hopeful therapeutic target for PC.
other	34512753	hsa-mir-485	Stomach Neoplasms	LncRNA SNHG7 Regulates Gastric Cancer Progression by miR-485-5p.
target gene	34512751	hsa-mir-485	Liver Neoplasms	LncRNA NKILA Promotes Epithelial-Mesenchymal Transition of Liver Cancer Cells by Targeting miR-485-5p.
lncRNA target	34512545	hsa-mir-1a	Diabetic Nephropathies	In summary, Sp1 induced lncRNA Rmrp could drive the expression of JunD via sponging miR-1a-3p in DN progression.
circRNA target	34512369	hsa-mir-942	Arthritis, Rheumatoid	5p may participate in the pathogenesis of RA through disordered Cullin 4B (CUL4B) and the traditional Chinese medicine compound Huangqin Qingre Chubi Capsule (HQC) may inhibit the pathogenesis of RA through the CUL4B/Wnt pathway.
circulation_biomarker_diagnosis_up	34512173	hsa-mir-23b	Hypoxia-Ischemia, Brain	As per our findings, miR-23b was upregulated in the serum of IBI patients and OGD-treated murine primary neurons. Collectively, downregulated miR-23b by c-Myc might alleviate IBI by upregulating Nrf2.
exosome	34512170	hsa-mir-19a	Pancreatic Carcinoma	These results indicated that exosomes might be an important mediator in the pathogenesis of PaC-DM, and miR-19a might be the effector molecule.
lncRNA target	34512159	hsa-mir-877	Urinary Bladder Neoplasms	Taken together, TQ induces the apoptosis through upregulating ROS level and impairing autophagic flux, and inhibiting the EMT and cell invasion via activating the miR
genetics_knock down_promote	34512151	hsa-mir-214	Glomerulonephritis, IGA	Functionally, knockdown of miR
lncRNA target	34512021	hsa-mir-1229	Colorectal Neoplasms	CONCLUSION: circTADA2A suppressed cell proliferation and migration in CRC through regulation of miR-1229/BCL2L10 axis, which suggested that circTADA2A might represent a novel potential target for the treatment of CRC.
other	34512002	hsa-mir-501	Ovarian Neoplasms	3p expression is significantly associated with poor survival in OC patients.
other	34511938	hsa-mir-455	Colorectal Neoplasms	To our knowledge, BCL2L12 and related molecules including hsa-miR-455 and hsa-miR-125a were firstly identified as potential biomarkers in the progression from adenoma to adenocarcinoma.
other	34511938	hsa-mir-125a	Colorectal Neoplasms	To our knowledge, BCL2L12 and related molecules including hsa-miR-455 and hsa-miR-125a were firstly identified as potential biomarkers in the progression from adenoma to adenocarcinoma.
target gene	34511937	hsa-mir-519b	Colorectal Neoplasms	Long Non-Coding RNA Duxap8 Facilitates Cell Proliferation and Induces Apoptosis in Colorectal Cancer via miR-519b/ZNF277 Axis.
circRNA target	34511934	hsa-mir-370	Colorectal Neoplasms	Moreover, circIFT80 inhibited the expression of hsa-miR
transcription factor target	34511489	hsa-mir-638	Osteosarcoma	The functions of hsa-miR-638 and target mRNAs for the development of lung metastasis in OS could be confirmed by quantitative Real-time PCR analysis.
genetics_overexpression_promote	34511434	hsa-mir-1	Subarachnoid Hemorrhage	In the SAH rat model, overexpressing circARF3 improved BBB integrity and neurological score, decreased neuronal apoptosis and microglial activation in ipsilateral basal cortex, with declined miR
lncRNA target	34511356	hsa-mir-34a	Squamous Cell Carcinoma of Head and Neck	MiR-34a-5p was a target of LINC01123, and its inhibitor could reverse the effect of silenced LINC01123 on the progression of OSCC.
genetics_overexpression_promote	34511042	hsa-mir-24	Lung Neoplasms	3p overexpression inhibited the proliferation and promoted the apoptosis of lung cancer cells.
lncRNA target	34511037	hsa-mir-380	Non-alcoholic Fatty Liver Disease	LRP2 was confirmed to be the target gene of miR
circulation_biomarker_diagnosis_down	34511033	hsa-mir-378b	Colorectal Neoplasms	The expression of CDKN2B-AS1, microRNA (miR)-378b, and cytoplasmic activation/proliferation-associated protein 2 (CAPRIN2) was analyzed in CRC patients and cell lines.
lncRNA target	34511023	hsa-mir-26a	Squamous Cell Carcinoma of Head and Neck	Sevoflurane use to target miR-26a/FOXO1 may be a novel alternative for LSCC therapy.
genetics_knock down_promote	34510683	hsa-mir-425	Alzheimer Disease	We tested the hypothesis that miR-425 loss correlates with enhanced levels of mRNA targets downstream, supporting APAM and AD progression.
genetics_GWAS	34510374	hsa-mir-7-1	Ischemic Stroke	The results of this study show that the rs6736 polymorphism in the 3'-untranslated region of the C14orf119 gene not only is associated with IS but also modifies the binding between miR
transcription factor target	34510318	hsa-mir-27a	Breast Neoplasms	Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer. CONCLUSION LPAR6 acts as a tumor suppressor in breast cancer and is positively regulated by miR-27a-3p.
genetics_overexpression_promote	34509805	hsa-mir-183	Osteoporosis	CONCLUSION: MiR-183 was up-regulated in osteoporosis, and miR-183 overexpression can inhibit osteoblast differentiation by targetedly down-regulating TGF-beta pathway member Smad4 to trigger osteoporosis.
circulation_biomarker_diagnosis_up	34509791	hsa-mir-486	Obesity	5p gene expression in the prediction of obesity was 0.44 with AUC 0.736 that has a sensitivity 60% and specificity 90%, CONCLUSION: The serum level of the miR
circulation_biomarker_diagnosis_up	34509791	hsa-mir-486	Fatty Liver	5p gene expression in the prediction of obesity was 0.44 with AUC 0.736 that has a sensitivity 60% and specificity 90%, CONCLUSION: The serum level of the miR
lncRNA target	34509500	hsa-mir-876	Colonic Neoplasms	3p showed significant inhibitory effects on cell proliferation, migration, and invasion, indicating its tumor suppressor role in the progression of colon cancer.
exosome	34509269	hsa-mir-129	Cognition Disorders	After treatment with Dex, miR-129 expression was elevated in brain tissues, and the neuroprotection of Dex on POCD rats was partially annulled after injection of miR-129 antagomir. In summary, Dex ameliorated SEV-induced POCD by elevating miR-129 and inhibiting TLR4 and NF-kappaB p65 phosphorylation.
other	34509164	hsa-mir-20a	Pulmonary Fibrosis	The results found that lung tissue fibrosis, Cd content significantly increased, lung tissue ion disturbance, miR-20a-3p down-regulation, M1/M2 imbalance, LXA4/FPR2 content decreased, MDA content increased, NF-kappaB/NLRP3, TGFbeta pathway, PPARgamma/Wnt pathway activated, and the expression of fibrosis-related factors increased.
other	34509057	hsa-mir-1	Arrhythmias, Cardiac	Furthermore, the expression of miR-133b was shown to distinguish patients with SVa and Va from the arrhythmia-free controls (AUC = 0.7273, p = 0.07 and AUC = 0.8030, p = 0.04, respectively).
other	34509057	hsa-mir-133b	Arrhythmias, Cardiac	CONCLUSIONS: miR-1, miR-133a, and miR-133b have the potential to become diagnostic biomarkers of arrhythmia in pediatric patients.
other	34509057	hsa-mir-133a	Arrhythmias, Cardiac	The aim of this study was to determine whether miR-1, miR-133a, and miR-133b can serve as biomarkers in the diagnosis of ventricular (Va) and supraventricular (SVa) arrhythmias in pediatric patients.
other	34508910	hsa-mir-519a	Parkinson Disease	RESULTS: NEAT1 and SP1 expressions were significantly upregulated, whereas miR-519a-3p was downregulated in MPP(+)-treated neuroblastoma cells in a dose- and time-dependent manner when compared with control groups. CONCLUSIONS: NEAT1 silencing protected against MPP(+)-induced neuroblastoma cell injury by regulating the miR-519a-3p/SP1 pathway.
genetics_overexpression_promote	34508764	hsa-mir-221	Colorectal Neoplasms	3p overexpression, showing the importance of EVs-derived miR
genetics_overexpression_promote	34508745	hsa-mir-411	Liver Cirrhosis	Drp1 overexpression abolished the inhibitory role of miR-411 in cell proliferation and fibrosis-associated factor levels in HSCs.
circulation_biomarker_diagnosis_ns	34508569	hsa-mir-181c	Heart Failure	CONCLUSIONS: Circulating miR-181c is a marker of the response to exercise training in HFpEF patients.
transcription factor target	34508321	hsa-mir-212	Cardiomyopathies	5p may attenuate MI by suppressing the NLRC5/VEGF/TGF-beta1/SMAD axis.
transcription factor target	34508321	hsa-mir-212	Myocardial Infarction	5p may attenuate MI by suppressing the NLRC5/VEGF/TGF-beta1/SMAD axis.
other	34508256	hsa-mir-16	Fetal Growth Retardation	RESULTS: Raw C(t) values of miR5p were similar between SGA and AGA births (P = 0.140) and between male and female births within SGA (P = 0.159) and AGA (P = 0.060) births while that of RNU44 and RNU48 were higher in SGA births (P = 0.008 and 0.006 respectively) and in male births within the SGA group (P = 0.005) for RNU44 and in female births within the AGA group (P = 0.048) for RNU48.
other	34508256	hsa-mir-16	Alopecia	RESULTS: Raw C(t) values of miR5p were similar between SGA and AGA births (P = 0.140) and between male and female births within SGA (P = 0.159) and AGA (P = 0.060) births while that of RNU44 and RNU48 were higher in SGA births (P = 0.008 and 0.006 respectively) and in male births within the SGA group (P = 0.005) for RNU44 and in female births within the AGA group (P = 0.048) for RNU48.
lncRNA target	34507637	hsa-mir-4651	Nasopharyngeal Carcinoma	Therefore, HOXC-AS1/miR-4651/FOXO6 may form a competing endogenous RNA (ceRNA) network that promotes NPC progression. In conclusion, our study demonstrates that HOXC-AS1 promotes NPC progression by sponging miR-4651 and regulating FOXO6 expression, thus providing potential pharmaceutical targets for developing new NPC treatments.
other	34507619	hsa-mir-199a	Hyperpigmentation, Skin	RT-PCR, western blot, melanin content analysis and luciferase activity assay were used to determine the hypopigmentation of miR-181a-5p and miR-199a.
other	34507619	hsa-mir-181a	Hyperpigmentation, Skin	RT-PCR, western blot, melanin content analysis and luciferase activity assay were used to determine the hypopigmentation of miR-181a-5p and miR-199a.
tissue_expression_ns	34507595	hsa-mir-31	Ovarian Neoplasms	CONCLUSION: In conclusion, hsa_circ_0004712 deficiency repressed OC development by mediating the miR3p/FZD4 pathway, predicting that hsa_circ_0004712 was a promising biomarker for OC diagnosis and therapy.
other	34507247	hsa-mir-199a	Primary Graft Dysfunction	With time, the RAI score increased gradually, and the difference of miR-199a-3p expression gradually increased (rs = 0.92, p < 0.001), suggesting that it may be related to acute rejection. CONCLUSION: miR-199a-3p might be an early warning marker for acute rejection after liver transplantation in rats.
lncRNA target	34506963	hsa-mir-21	Hemangioma, Infantile	CONCLUSIONS To the best of our knowledge, the present study has, for the first time, revealed downregulation of miR-21 in VMs, which might contribute to decreased collagen expression via the TGF-/Smad3/miR-21 signaling feedback loop.
exosome	34506494	hsa-mir-122	Liver Cirrhosis	CONCLUSION: Exosomal miR-122 may serve as a useful non-invasive biomarker for liver fibrosis, especially in patients with non-viral etiologies of chronic liver disease.
other	34506226	hsa-mir-155	Aging, Premature	Hsa-miR5p might be the mediator in linking cellular senescence to vascular aging and atherosclerosis.
lncRNA target	34505723	hsa-mir-18a	Myocardial Infarction	These data for the first time suggest that lncRNA CASC2 have better protective effects on AMI, which could reduce oxidative stress through their carried miR-18a and subsequently downregulating the SIRT2/ROS pathway.
circulation_biomarker_prognosis_ns	34505413	hsa-mir-342	Parathyroid Neoplasms	CONCLUSIONS: Serum miRNA3p could be a promising biomarker for PC to improve diagnosis and prognosis.
other	34504842	hsa-mir-1471	Stomach Neoplasms	Overall, the circITGA7/miR-1471/MTDH signaling pathway may play a crucial role in GC, providing a new potential mechanism involved in GC progression.
other	34504813	hsa-mir-26a	Neonatal Sepsis	Conclusion: A lower baseline miR-26a expression in PBMCs indicated the occurrence of early-onset neonatal sepsis, and a reduced miR-26a expression might be partly related to the inflammatory process and PTEN upregulation.
genetics_knock down_suppress	34504639	hsa-mir-34	Endometritis	Thus, the knockdown of miR-34a might be a new direction for the treatment of endometritis.
genetics_knock down_suppress	34504639	hsa-mir-34a	Endometritis	Thus, the knockdown of miR-34a might be a new direction for the treatment of endometritis.
other	34504621	hsa-mir-223	Esophageal Fibrosis	5p.
other	34504621	hsa-mir-21	Esophageal Fibrosis	5p.
other	34504621	hsa-mir-218	Esophageal Fibrosis	5p.
other	34504617	hsa-mir-124	Intracranial Aneurysm	Overall, the present study demonstrated that miR5p could prevent the occurrence and development of cerebral aneurysm by downregulating the expression of FoxO1.
target gene	34504608	hsa-mir-184	Prostatic Neoplasms	miR-184 delays cell proliferation, migration and invasion in prostate cancer by directly suppressing DLX1.
transcription factor target	34504602	hsa-mir-144	Glioma	3p suppressed BCL6 expression by targeting the 3'-UTR sequence of BCL6.
genetics_overexpression_suppress	34504600	hsa-mir-1269a	Colorectal Neoplasms	circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR-1269a/VASH1 axis.
other	34504593	hsa-mir-29	Cerebral Infarction	In conclusion, the results of the present study suggested that SNHG1 may reduce microglial cell activity by regulating the expression of miR3p, indicating its potential protective role in cerebral infarction.
genetics_knock down_suppress	34504588	hsa-mir-506	Pancreatic Neoplasms	Knockdown of LINC00657 inhibits the viability, migration and invasion of pancreatic cancer cells by regulating the miR-520h/CKS1B axis.
target gene	34504582	hsa-mir-221	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MicroRNA-221 regulates cell activity and apoptosis in acute lymphoblastic leukemia via regulating PTEN.
circRNA target	34504560	hsa-mir-145	Osteosarcoma	In summary, circ_0008932 may be a novel oncogenic factor during the progression and development of OS by targeting miR
transcription factor target	34504558	hsa-mir-328a	Cranial Nerve Injuries	miR-328a-3p was differentially expressed in peripheral nerve stumps after nerve injury. Collectively, the present study demonstrated that dysregulated miR-328a-3p after peripheral nerve injury may affect the migration and angiogenesis of endothelial cells and contribute to peripheral nerve regeneration.
transcription factor target	34504558	hsa-mir-328a	Peripheral Nerve Injuries	Collectively, the present study demonstrated that dysregulated miR-328a-3p after peripheral nerve injury may affect the migration and angiogenesis of endothelial cells and contribute to peripheral nerve regeneration.
other	34504555	hsa-mir-483	Cerebrovascular Disorders	5p expression may be a candidate biomarker for ACAS diagnosis and the prediction of cerebrovascular event occurrence.
other	34504555	hsa-mir-483	Carotid Stenosis	5p expression may be a candidate biomarker for ACAS diagnosis and the prediction of cerebrovascular event occurrence.
lncRNA target	34504547	hsa-mir-7	Breast Neoplasms	TGFBR2-Smad3-CD44 regulatory axis was highly efficient in the inhibition of CD44 expression in BCSCs, and that the regulatory expression of ALDH1A3 and miR-7 may provide a strategy in the therapy of breast cancer.
lncRNA target	34504167	hsa-mir-642a	Wilms Tumor	Taken together, these data provide insight into the molecular mechanisms by which miR-642a-5p acts as a tumor suppressor in PCa, an effect partially mediated by regulating genes involved in cell cycle control; and restoration of miR
lncRNA target	34504167	hsa-mir-642a	Prostatic Neoplasms	Taken together, these data provide insight into the molecular mechanisms by which miR-642a-5p acts as a tumor suppressor in PCa, an effect partially mediated by regulating genes involved in cell cycle control; and restoration of miR
lncRNA target	34504061	hsa-mir-508	Lung Neoplasms	5p elevation inhibited proliferation, migration, and invasion of LC cells and promoted LC cell apoptosis, and also suppressed the in vivo tumor growth.
lncRNA target	34503538	hsa-mir-206	Pituitary Neoplasms	It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma.
lncRNA target	34503538	hsa-let-7e	Pituitary Neoplasms	It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma.
lncRNA target	34503538	hsa-mir-26b	Pituitary Neoplasms	It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma.
lncRNA target	34503538	hsa-mir-138	Pituitary Neoplasms	It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma.
lncRNA target	34503528	hsa-mir-4721	Nasopharyngeal Carcinoma	We found that miR-4721, FOXA1 and Nanog control their expressions through a negative feedback loop and then activate the downstream regulator of stem cell signaling to promote the enrichment and metastasis of NPC stem cells.
genetics_knock down_promote	34503521	hsa-mir-193	Sepsis	Knockdown STAT3 reversed the role of inhibited miR
genetics_knock down_promote	34503521	hsa-mir-193	Cardiomyopathies	Knockdown STAT3 reversed the role of inhibited miR
tissue_expression_ns	34503396	hsa-mir-155	Multiple Sclerosis	It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks.
tissue_expression_ns	34503396	hsa-mir-146a	Multiple Sclerosis	It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks.
other	34503175	hsa-mir-22	Multiple Myeloma	Results: We found an inverse correlation between MYC and miR-22 expression, which is associated with poor outcome in IMiD-treated MM patients. Conclusions: Taken together, our findings indicate that: (1) low miR-22 expression could represent a potential predictive biomarker of poor lenalidomide response in MM patients; and (2) miR-22 reduces MYC oncogenic activity, thus triggering a novel synthetic lethality loop, which sensitizes MM cells to lenalidomide.
circulation_biomarker_diagnosis_ns	34503070	hsa-mir-371a	Neoplasms, Germ Cell and Embryonal	The miR-371a-3 cluster members are an example, monitoring the presence of malignant germ cell tumors based on patient serum/plasma analyses.
other	34502497	hsa-mir-34	Colorectal Neoplasms	In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer.
other	34502497	hsa-mir-200	Colorectal Neoplasms	In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer.
other	34502497	hsa-mir-34a	Colorectal Neoplasms	In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer.
tissue_expression_ns	34502449	hsa-mir-408	Avitaminosis	Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency.
tissue_expression_ns	34502449	hsa-mir-98	Avitaminosis	Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency.
other	34502341	hsa-mir-1885	Clubfoot	The Bra-miR1885-mediated down-regulation of both genes was detected for up to 15 days post-inoculation in the clubroot-resistant line CR Shinki and in the clubroot-susceptible line 94SK.
genetics_overexpression_suppress	34502294	hsa-mir-24	immunodeficiency 35	3p overexpression, and further offset the effects of miR
other	34502118	hsa-mir-497	Burns	Moreover, we identified miR5p as stably downregulated in tissue and dISF in the early phase after a burn injury.
exosome	34500436	hsa-mir-185	Carcinoma, Non-Small-Cell Lung	5p inhibits tumor cell-derived exosomes-mediated proliferation, migration and invasion of NSCLC cells by downregulating RAB35 expression.
lncRNA target	34500373	hsa-mir-3150b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LncRNA RP11-116G8.5 promotes malignant behaviors of LUSC through sponging miR-3150b-3p/miR
lncRNA target	34500373	hsa-mir-6870	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LncRNA RP11-116G8.5 promotes malignant behaviors of LUSC through sponging miR-3150b-3p/miR
lncRNA target	34499929	hsa-mir-2355	Lymphoma, B-Cell	5p to regulate ATG5, revealing a novel molecular mechanism of ARRDC1-AS1 in DLBCL and suggested ARRDC1-AS1 as a potential target in DLBCL.
epigenetics	34499308	hsa-mir-192	Colorectal Neoplasms	CONCLUSIONS: It seems that MIR192-2 promoter hypermethylation might regulate the expression of SOX4 and therefore modulate metastasis in CRC.
lncRNA target	34499009	hsa-mir-363	Stomach Neoplasms	The mechanism of circ0005654 on miR-363/specificity protein 1 (sp1) axis was evaluated in GC cells by bioinformatics analysis, luciferase reporter, FISH, and ChIP assays. In conclusion, circ0005654 expedites the GC development via miR-363/sp1/myc/Wnt/beta-catenin axis and is a new biomarker for GC treatment regimen.
other	34499007	hsa-mir-493	Uterine Cervical Neoplasms	The expression of CCAT2, the miR5p microRNA (miRNA), and mRNA was detected using qRT-PCR.
circRNA target	34499003	hsa-mir-495	Dehydration	In conclusion, circ-UQCRC2 contributed to LPS-induced injury of 16HBE cells by targeting miR3p/MYD88 signalling-mediated inflammatory response and oxidative stress.
other	34498815	hsa-mir-486a	Xerostomia	CONCLUSIONS: Radiation was found to induce damage of the submandibular gland and affect Cdkn1a expression by regulating the expression of miR-486a-3p in a xerostomia murine model. Therefore, modulation of miR-486a-3p and the Cdkn1a gene in a xerostomia murine model might improve damage of the submandibular gland.
other	34498720	hsa-mir-199	Glioblastoma	In conclusion, the findings of the present study identified novel roles for circFLNA in GBM and indicated that the circFLNA/miR1993p signaling axis may serve an important role in GBM progression.
lncRNA target	34498716	hsa-mir-451a	Carcinoma, Hepatocellular	An understanding of the competing endogenous RNA network of ZSCAN16AS1/miR451a/ATF2 in HCC might be instrumental in the development of attractive targets for molecular therapy.
other	34498713	hsa-mir-4792	Meningitis, Cryptococcal	In addition, following antifungal treatment in patients with cryptococcal meningitis, the levels of miR4792 in the cerebrospinal fluid significantly increased, whilst the expression of EGFR significantly decreased. In addition, receiver operator characteristic analysis revealed miR4792 (AUC(ROC)=0.75) and EGFR (AUC(ROC)=0.79) as potential diagnostic markers in patients with cryptococcal meningitis.
transcription factor target	34498712	hsa-mir-221	Fibrosis	The expression of miR221 was quantified in a liver fibrosis model in vivo and in vitro, and its specific target gene lysosomeassociated membrane glycoprotein 2 (LAMP2) was predicted by bioinformatics.
genetics_overexpression_promote	34498707	hsa-mir-133a	Sepsis	Compared with the control group, the expression of FGD5AS1 was decreased and the expression of miR133a3p was increased in the sepsis group. These results indicated that FGD5AS1 is the competitive endogenous RNA of miR133a3p on AQP1, and thus FGD5AS1 overexpression may be able to inhibit the inflammatory response in sepsis.
genetics_overexpression_promote	34498706	hsa-mir-1281	Colorectal Neoplasms	Furthermore, LINC00963 overexpression plasmid, LINC00963 small interfering RNA, miR1281 mimics or miR1281 inhibitors were transfected into CRC cells, and Cell Counting Kit8, colony formation and Transwell assays were adopted to study the effects of LINC00963 and miR1281 on the malignant phenotypes of CRC cells.
lncRNA target	34498594	hsa-mir-130a	Atherosclerosis	CONCLUSION: These results strongly support that miRNA-130a suppression can protect against atherosclerosis through inhibiting inflammation by regulating the PPARgamma/ NF-kappaB expression.
transcription factor target	34498538	hsa-mir-1	Esophageal Neoplasms	Collectively, the current study demonstrated that Que exerted inhibitory effects on EC cells by inducing miR
circulation_biomarker_prognosis_ns	34497895	hsa-mir-181a	Ovarian Neoplasms	Objective: To determine the possibility of early diagnosis and prognosis of ovarian cancer (OC) via detecting miR-181a in circulating tumor cells (CTCs) of OC and to solve clinical difficulties in OC tissue sample collection.
genetics_overexpression_promote	34497853	hsa-mir-29c	Melanoma	CONCLUSION: Overexpression of miR-29c-3p suppresses CDCA4 expression and decreases proliferation, migration, invasion, apoptosis, and EMT of MM cells, thus hindering MM progression.
other	34497805	hsa-mir-23b	Parkinson Disease	Additionally, miR-23b-3p was identified as a novel direct regulator of alpha-synuclein, which is possibly the key component in PD.
other	34497755	hsa-mir-142	Adenocarcinoma of Lung	5p/GOLPH3 affected overall survival of LUAD patients.
other	34497682	hsa-mir-18a	Lung Diseases	Thus, we have not only established a rat model for lung IR and enumerated the important miRNAs involved in IR but have also extensively characterized the role of miR-18a-5p.
other	34497524	hsa-mir-1	Osteoarthritis, Knee	In addition, knee OA-related key miRNAs such as miR-101, miR-181a, miR-29, miR-9, and miR-221, and pathways such as Wnt signaling, HIF-1 signaling, PI3K-Akt signaling, and axon guidance pathways were also identified. Among above identified knee OA-related key genes, pathways and miRNAs, genes such as AHR, HEY1, MYC, GAP43, and PTN, pathways like axon guidance, and miRNAs such as miR-17, miR-21, miR-155, miR-185, and miR-1 are lack of research and worthy for future investigation.
lncRNA target	34497517	hsa-mir-221	Seizures	3p/HIF-1alpha as essential component in pathogenesis of VPA-resistant epilepsy which represent therapeutic antiseizure targets.
lncRNA target	34497517	hsa-mir-221	Drug Resistant Epilepsy	3p/HIF-1alpha as essential component in pathogenesis of VPA-resistant epilepsy which represent therapeutic antiseizure targets.
circulation_biomarker_diagnosis_up	34497505	hsa-mir-342	Alzheimer Disease	5p in plasma were associated with faster cognitive decline in patients with mild AD after 2 years of follow-up.
target gene	34497267	hsa-mir-1246	Ovarian Neoplasms	METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246.
circulation_biomarker_diagnosis_ns	34497265	hsa-mir-3157	Carcinoma, Non-Small-Cell Lung	3p is involved in the formation of pre-metastatic niche formation before tumor metastasis and may be used as a blood-based biomarker for NSCLC metastasis.
lncRNA target	34497156	hsa-mir-28	Carcinoma, Renal Cell	SNHG17/miR3p/H2AXaxis might be involved in RCC progression, which provided a potential therapeutic target for RCC.
lncRNA target	34497040	hsa-mir-372	Carcinoma, Hepatocellular	3p via PART1 delivery to promote macrophage M2 polarization in HCC.
lncRNA target	34496842	hsa-mir-149	Esophageal Squamous Cell Carcinoma	In addition, colony formation and invasion assays verified that GACAT3 promotes ESCC tumor progression through miR-149. CONCLUSIONS: These findings indicate that GACAT3 functions as an oncogene by acting as a ceRNA for miR-149 to modulate FOXM1 expression in ESCC, suggesting that GACAT3 might constitute a therapeutic target in ESCC.
lncRNA target	34496838	hsa-mir-422a	Colorectal Neoplasms	CONCLUSIONS: LINC00958 promoted MAPK1 expression and cell proliferation and suppressed cell apoptosis and radiosensitivity by targeting miR-422a, which suggests that it is a potential biomarker for the prognosis and treatment of colorectal cancer.
genetics_overexpression_promote	34496829	hsa-mir-611	Adenocarcinoma of Lung	Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression reversed the effects of silenced LINC00520 on proliferative and migratory capabilities in LUAD cells.
genetics_knock down_promote	34496800	hsa-mir-140	Ovarian Neoplasms	3p overexpression suppressed the viability, proliferation and invasion of ovarian cancer cells.
lncRNA target	34496750	hsa-mir-935	Diabetes Mellitus	Targeted inhibition of miR-504 and miR-935 could reverse the high-glucose-induced testicular complications, thus posing as a potential therapeutic approach in diabetic testicular injury.
lncRNA target	34496750	hsa-mir-504	Diabetes Mellitus	Targeted inhibition of miR-504 and miR-935 could reverse the high-glucose-induced testicular complications, thus posing as a potential therapeutic approach in diabetic testicular injury.
lncRNA target	34496413	hsa-mir-519d	Thyroid Cancer, Papillary	MiR-519d-3p may be a tumor-inhibiting miRNA in PTC, and that miR-519d-3p/FOXQ1 axis mediated PTC tumor progression from cell proliferation, migration, and invasion in PTC cells.
lncRNA target	34496364	hsa-mir-181b	Inflammation	CONCLUSION: SNHG1 was involved in LPS-induced microglial activation and inflammation response via targeting miR-181b, providing another evidence of the roles of SNHG1 implicated in neuroinflammation of microglia.
lncRNA target	34496364	hsa-mir-181b	Neurogenic Inflammation	INTRODUCTION: Long noncoding RNA small nuclear host gene 1 (SNHG1) was involved in neuroinflammation in microglial BV-2 cells; however, its interaction with microRNA (miR)-181b in lipopolysaccharide (LPS)-induced BV-2 cells remained poor. CONCLUSION: SNHG1 was involved in LPS-induced microglial activation and inflammation response via targeting miR-181b, providing another evidence of the roles of SNHG1 implicated in neuroinflammation of microglia.
lncRNA target	34496348	hsa-mir-92a	Stomach Neoplasms	CONCLUSION: Thus, we concluded that PITPNA-AS1 induced the development of GC cells by inhibiting miR-92a-3p and inducing SOX4.
other	34495821	hsa-mir-526b	Reperfusion Injury, Cerebral Ischemia	Eventually, the promoting role of the circ_0062166/miR-526b-5p/BCL2L13 axis in the CIR injury was verified. CONCLUSION: To sum up, the present study has demonstrated that circ_0062166/miR-526b-5p/BCL2L13 axis accelerated the progression of CIR injury, which might provide effective strategies for CIR injury therapy.
circulation_biomarker_diagnosis_ns	34495485	hsa-mir-124	Atrial Fibrillation	In conclusion, these findings suggested that circulating exosomal miRNAs may serve as novel biomarkers for AF, and miR
transcription factor target	34495404	hsa-mir-17	Depression	Overall, our findings indicated that Nrf2 inhibited miR5p expression and promoted Wfs1 transcription, thereby alleviating cognitive dysfunction and inflammatory injury in rats with depression-like behaviors.
circulation_biomarker_diagnosis_ns	34495394	hsa-mir-16	Breast Neoplasms	In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening.
circulation_biomarker_diagnosis_ns	34495394	hsa-mir-21	Breast Neoplasms	In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening.
circulation_biomarker_diagnosis_ns	34495394	hsa-mir-155	Breast Neoplasms	In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening.
lncRNA target	34495369	hsa-mir-340	Corneal Neovascularization	5p mediates the therapeutic effect of MSCs on CNV via binding and repressing the expressions of EMP2 and PROX1.
circulation_biomarker_diagnosis_up	34495077	hsa-mir-195	Diabetes Mellitus, Type 2	5p circulating in the peripheral blood served as a novel biomarker and therapeutic target for EH and T2DM, which could eventually help address major challenges during the diagnosis and treatment of EH and T2DM.
circulation_biomarker_diagnosis_up	34495077	hsa-mir-195	Essential Hypertension	5p circulating in the peripheral blood served as a novel biomarker and therapeutic target for EH and T2DM, which could eventually help address major challenges during the diagnosis and treatment of EH and T2DM.
other	34494941	hsa-mir-532	Carcinoma, Non-Small-Cell Lung	3p/FOXR2 network.
other	34494934	hsa-mir-146a	Osteoarthritis	The expressions of TrkA, TrkB and ShcB and NEAT1 were up-regulated in OA and IL-1beta-stimulated chondrocytes, while miR-146a-3p was donwnregulated and was negatively correlated with TrkB or NEAT1.
other	34494412	hsa-mir-140	Tendon Injuries	Modulation of the H19/miR5p/VEGFA axis in TDSCs is a new potential strategy for clinical treatment of tendon injury.
other	34494305	hsa-mir-125a	Stomach Neoplasms	Long non-coding RNA TNK2 AS1/microRNA-125a-5p axis promotes tumor growth and modulated phosphatidylinositol 3 kinase/AKT pathway.
transcription factor target	34493899	hsa-mir-143	Pneumonia	Therefore, miR3p is considered a potential molecular target for the treatment of lung inflammation.
transcription factor target	34493702	hsa-mir-199a	Arteriosclerosis	In vivo experiments confirmed that EPC-EVs inhibited ferroptosis of endothelial cells and then alleviated the occurrence of AS via the miR-199a-3p/SP1 axis. To conclude, EPC-EVs transferred miR-199a-3p to inhibit SP1, thus repressing ferroptosis of endothelial cells and retarding the occurrence of AS.
other	34493366	hsa-mir-221	Carcinoma, Ductal, Breast	Higher expression of miR-221, an oncomiR that facilitates entry into the cell cycle S-phase, is regulated by c-MYC, which is expressed more in breast cancer samples from B/AA patients.
other	34493366	hsa-mir-135b	Carcinoma, Ductal, Breast	Furthermore, the cell migration- and invasion-promoting miRNA, miR-135b, has increased relative expression in B/AA patients.
genetics_overexpression_promote	34493358	hsa-mir-605	Carcinoma, Non-Small-Cell Lung	3p downregulation or MACC1 overexpression.
circulation_biomarker_prognosis_down	34493304	hsa-mir-935	Pneumonia, Mycoplasma	RESULTS: MiR-3935 expression is significantly decreased in both placentas and peripheral blood specimens of PE, and functionally, miR-3935 promotes EMT of trophoblast cells.
lncRNA target	34493304	hsa-mir-935	Uterine Diseases	CONCLUSIONS: Together these results uncover a hitherto uncharacterized role of miR-3935/TRAF6/RGS2 axis in the function of human trophoblasts, which may pinpoint the molecular pathogenesis of PE and may be a prognostic biomarker and therapeutic target for such obstetrical diseases as PE.
other	34493227	hsa-mir-528	Dehydration	Network analysis revealed TCONS_00021861/miR528-3p/YUCCA7 regulatory axis as a hub involved in drought response. CONCLUSIONS: TCONS_00021861 could regulate YUCCA7 by sponging miR528-3p, which in turn activates IAA biosynthetic pathway and confer resistance to drought stress.
genetics_knock down_suppress	34493213	hsa-mir-128	Uterine Cervical Neoplasms	Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis.
circulation_biomarker_diagnosis_ns	34493187	hsa-mir-27b	Acquired Immunodeficiency Syndrome	OBJECTIVE: The aim of this cross-sectional study was to assess the expression pattern of miR-27b, -29, -150, and -221, as well as their relationship with CD4+ T-cell count, HIV-1 viral load, and nef gene expression in peripheral blood mononuclear cells (PBMCs) of untreated viremic patients and in LTNPs.
exosome	34492742	hsa-mir-21	Hemoglobinuria, Paroxysmal	For the subgroup analysis, it was showed that ex-miR-21 had a superior diagnostic accuracy on identifying PC. CONCLUSION: Exosomal microRNA-21 can serve as an effective and widely used diagnostic biomarker for cancer, especially in PC.
genetics_overexpression_suppress	34492599	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	MicroRNA-21 (miR-21) is frequently overexpressed in various cancer types including breast and non-small cell lung cancer and its functions can be inhibited by miR inhibitor (miR-21i).
other	34492519	hsa-mir-5703	Breast Neoplasms	CONCLUSION: Identification of miR-5703 and its network for Runx2 regulation directly or indirectly in breast cancer cells could significantly advance our understanding of breast cancer-mediated bone metastasis.
lncRNA target	34491827	hsa-mir-4429	Adenocarcinoma of Lung	This research discovered that miR-4429 was low expressed in lung ADC cells. Consequently, miR-4429 can inactivate Wnt/beta-catenin signaling pathway by targeting beta-catenin and prevent oncogene expression in lung ADC cells.
exosome	34491386	hsa-mir-214	Rhabdoid Tumor, Kidney	Exosomal miR3p expression level determined by qRT-PCR was significantly higher in RTK-derived cell lines than in the human embryonic renal cell line or NB-derived cell lines.
genetics_GWAS	34491311	hsa-mir-29a	Leiomyoma	Leiomyomas bearing the MED12 mutation expressed higher levels of MIAT and lower levels of microRNA 29 family (miR-29a, -b, and -c) compared with MED12 wild-type leiomyomas. In a 3-dimensional spheroid culture system, transient transfection of MIAT siRNA in leiomyoma smooth muscle cell (LSMC) spheroids resulted in upregulation of miR-29 family and downregulation of miR-29 targets, collagen type I (COL1A1), collagen type III (COL3A1), and TGF-beta3 (transforming growth factor beta-3).
transcription factor target	34490833	hsa-mir-199b	Acute Kidney Injury	We aimed to explore whether DMY could affect Nrf2 pathway by regulating miR-199b-3p and played a protective role in septic AKI. MiR-199b-3p was increased in septic AKI models, DMY might alleviate septic AKI by regulating miR-199b-3p to affect the Nrf2 pathway.
transcription factor target	34490709	hsa-mir-211	Urethritis	parvum-infected cells and UpVF-transfected cells identified miR-211 and miR-214 as the negative regulators of the apoptotic cascade under ER stress. * UpVF triggered ER stress but suppressed apoptotic cascade via miR-211 and -214.
other	34490709	hsa-mir-214	Urethritis	parvum-infected cells and UpVF-transfected cells identified miR-211 and miR-214 as the negative regulators of the apoptotic cascade under ER stress.
lncRNA target	34490480	hsa-mir-486	Stomach Neoplasms	miR4865p also suppressed cell cycle process and migration and promoted apoptosis in GC cells, as verified by propidium iodide (PI) staining, Transwell assay and PI/Annexin V staining.
transcription factor target	34490081	hsa-mir-425	Colorectal Neoplasms	Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function.
transcription factor target	34490081	hsa-mir-576	Colorectal Neoplasms	Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function.
transcription factor target	34490081	hsa-mir-576	Liver Neoplasms	Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function.
transcription factor target	34490081	hsa-mir-425	Liver Neoplasms	Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function.
other	34490028	hsa-let-7g	Hamartoma Syndrome, Multiple	5p in the hippocampus and CBL and PVRL1 in the hypothalamus.
other	34490028	hsa-mir-19b	Hamartoma Syndrome, Multiple	5p in the hippocampus and CBL and PVRL1 in the hypothalamus.
other	34490028	hsa-mir-125a	Hamartoma Syndrome, Multiple	5p in the hippocampus and CBL and PVRL1 in the hypothalamus.
other	34490028	hsa-mir-194a	Hamartoma Syndrome, Multiple	5p in the hippocampus and CBL and PVRL1 in the hypothalamus.
other	34490028	hsa-mir-7-1	Hamartoma Syndrome, Multiple	5p in the hippocampus and CBL and PVRL1 in the hypothalamus.
circRNA target	34489401	hsa-mir-223	Gallbladder Neoplasms	Mechanistic analysis further highlighted that circbeta-catenin promoted Stathmin 1 (STMN1) expression through sponging miR-223 in GBC progression. In summary, our findings indicated that circbeta-catenin/miR-223/STMN1 axis could regulate cell growth and Warburg effect in GBC.
other	34489228	hsa-mir-26a-1	Asthma	3p and hsa-miR-376a-3p could be used to differentiate between eosinophilic and noneosinophilic asthma.
other	34489228	hsa-mir-376a	Asthma	3p and hsa-miR-376a-3p could be used to differentiate between eosinophilic and noneosinophilic asthma.
genetics_knock down_suppress	34489160	hsa-mir-181a	Inflammation	Furthermore, the regulatory effects of MIAT knockdown in cell proliferation, apoptosis, and inflammatory injury was reversed by inhibition of miR-181a-5p or overexpression of JAK2 in OGD-treated HCM.
genetics_knock down_suppress	34489160	hsa-mir-181a	Myocardial Ischemia	CONCLUSION: MIAT knockdown inhibited apoptosis and inflammation by regulating JAK2/STAT3 signaling pathway via targeting miR-181a-5p in myocardial ischemia model.
genetics_GWAS	34488676	hsa-mir-126	Cervical Intraepithelial Neoplasia	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-21	Cervical Intraepithelial Neoplasia	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-126	Uterine Cervical Neoplasms	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-221	Cervical Intraepithelial Neoplasia	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-221	Uterine Cervical Neoplasms	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-21	Uterine Cervical Neoplasms	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-26b	Uterine Cervical Neoplasms	BACKGROUND: miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated.
genetics_GWAS	34488676	hsa-mir-26b	Cervical Intraepithelial Neoplasia	BACKGROUND: miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated.
genetics_GWAS	34488676	hsa-mir-222	Cervical Intraepithelial Neoplasia	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
genetics_GWAS	34488676	hsa-mir-222	Uterine Cervical Neoplasms	METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC.
other	34488675	hsa-mir-139	Esophageal Squamous Cell Carcinoma	We also constructed a potential UBE2C-related ceRNA network for ESCC (HCP5/has-miR5p/UBE2C).
transcription factor target	34488621	hsa-mir-100	Hypertriglyceridemia	CONCLUSIONS: Our findings demonstrate a protective role of miR-100 in high fat diet induced metabolic syndrome and liver steatosis, partially mediated by the direct repression of CD36 and attenuation of hepatic lipid storage, implicating miR-100 as a possible therapeutic target in liver steatosis.
transcription factor target	34488621	hsa-mir-100	Fatty Liver	CONCLUSIONS: Our findings demonstrate a protective role of miR-100 in high fat diet induced metabolic syndrome and liver steatosis, partially mediated by the direct repression of CD36 and attenuation of hepatic lipid storage, implicating miR-100 as a possible therapeutic target in liver steatosis.
lncRNA target	34488538	hsa-mir-26b	Squamous Cell Carcinoma of Head and Neck	Hence, targeting miR-26b-5p could be a promising therapeutic strategy for the treatment of TSCC.
lncRNA target	34488537	hsa-mir-556	Carcinoma, Non-Small-Cell Lung	5p ablation triggered pyroptotic cell death in cisplatin-treated CR-NSCLC cells via upregulating NLRP3, and the promoting effects of miR
genetics_knock down_promote	34488224	hsa-mir-483	Breast Neoplasms	Finally, rescue experiments revealed that the tumor-inhibiting actions of TTC39A-AS1 knockdown on the malignant characteristics of BC cells could be reversed by inhibiting miR
lncRNA target	34487733	hsa-mir-10b	Stomach Neoplasms	Therefore, our results elucidate the tumor suppressor role of miR-10b-5p in gastric cancer in which it acts as a negative regulator of Tiam1 and also provide a molecular mechanism for agomir-10b-5p to treat gastric cancer.
lncRNA target	34487020	hsa-mir-525	Carcinoma, Non-Small-Cell Lung	5p in NSCLC cells, and inhibiting LINC01207 and miR
lncRNA target	34486899	hsa-mir-15a	AIDS-Related Complex	RESULTS: Circ_0122396 and FGF1 expression were significantly downregulated, but miR-15a-5p expression was upregulated in ARC tissues or/and H(2)O(2)-treated SRA01/04 cells in comparison with control groups. CONCLUSION: Circ_0122396 ameliorated H(2)O(2)-triggered cell injury by inducing FGF1 through sponging miR-15a-5p, providing a potential target for ARC therapy.
lncRNA target	34486705	hsa-mir-142	Liver Failure	5p inhibitors can mitigate septic liver injury by downregulating the inflammation and apoptosis via targeting SOCS1.
lncRNA target	34486677	hsa-mir-28	Keloid	Finally, our data indicated that LINC00937 inhibited the ECM deposition and proliferation of keloid fibroblasts by inhibiting miR
genetics_overexpression_promote	34486645	hsa-mir-192	Thyroid Cancer, Papillary	Overexpression of miR
circulation_biomarker_diagnosis_up	34486532	hsa-mir-148a	Colonic Neoplasms	Colon cancer stem cells (CD44+/CD133+) were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
circulation_biomarker_diagnosis_up	34486532	hsa-mir-152	Colonic Neoplasms	Colon cancer stem cells (CD44+/CD133+) were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
circulation_biomarker_diagnosis_up	34486487	hsa-mir-29b	Osteoporosis	We compared the serum levels of XIST and miR-29b-3p among the patients with and without OP. In conclusion, XIST is highly expressed in OP, and regulates NNMT by sponging miR-29b-3p to suppress the osteogenic differentiation of BMSCs.
other	34486082	hsa-mir-155	Prostatic Neoplasms	Our results corroborate that miR-155 regulates TERF1 expression in prostate cancer.
lncRNA target	34485716	hsa-mir-1	Adenocarcinoma of Lung	However, the inhibitory effect of miR-31 on tumorigenesis, invasion and metastasis of lung adenocarcinoma CSCs suggested its complexity in the regulation of lung adenocarcinoma, which may be related to its extensive regulation of various target genes.
circulation_biomarker_diagnosis_up	34485531	hsa-mir-25	Nasopharyngeal Carcinoma	The miR-25 inhibitor and target egg gene expression plasmids were cotransfected into HONE-1 cells for rescue experiments to investigate whether miR-25 inhibits proliferation of nasopharyngeal carcinoma cells by target genes.
lncRNA target	34485523	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	3p's low expression may facilitate tumorigenesis and evolution in HNSCC through signaling pathways.
lncRNA target	34485516	hsa-mir-143	Arthritis, Rheumatoid	3p inhibited osteoclast differentiation and decreased the levels of M-CSF and RANKL during osteoclast differentiation.
other	34485516	hsa-mir-143	Arthritis	Existing studies have shown that abnormal miR3p expression was observed in both RA patients and arthritis animals, which can participate in osteoclast differentiation, and mitogen-activated protein kinase (MAPK) signaling pathway was closely related to osteoclast differentiation.
lncRNA target	34485394	hsa-mir-135b	Myocardial Reperfusion Injury	The results of this study elucidate a novel function of miR-135b-3p in exacerbating cardiomyocyte ferroptosis, providing a new therapeutic target for improving I/R injury.
transcription factor target	34485279	hsa-mir-7062	Carcinoma, Hepatocellular	Our study found the role of miRNA5p in regulating osteoclast formation, and our findings provided a potential therapeutic target in treatment of bone metastasis of CRC.
transcription factor target	34485279	hsa-mir-7062	Colorectal Neoplasms	Our study found the role of miRNA5p in regulating osteoclast formation, and our findings provided a potential therapeutic target in treatment of bone metastasis of CRC.
circRNA target	34485272	hsa-mir-143	Metabolic Syndrome	CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR
circRNA target	34485272	hsa-mir-143	Metabolic Diseases	CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR
genetics_knock down_suppress	34485123	hsa-mir-361	Colorectal Neoplasms	3p, which was inhibited by MIR31HG overexpression, repressed the malignant behaviors of CRC cells.
lncRNA target	34485121	hsa-mir-181b	Gallbladder Neoplasms	CONCLUSION: In this study, downregulation of miR-181b-5p inhibits the viability, migration, and glycolysis of GBC by upregulating PDHX under hypoxia.
other	34484820	hsa-mir-149	Wounds and Injuries	However, it is unclear about the roles of miR-149 in endothelial injury.
circulation_biomarker_prognosis_ns	34484811	hsa-mir-125b	Pancreatic Carcinoma	In situ hybridization for miR detection in the paired resected human PDAC tissues showed that miR-125b-5p and miR-99a-5p are highly expressed in inflammatory cells in the tumor stroma, located in clusters of CD79A expressing cells of the B-lymphocyte lineage. In conclusion, we found that circulating miR-125b-5p and miR-99a-5p are potential immune-cell related prognostic biomarkers in PDAC patients after surgery.
circulation_biomarker_prognosis_ns	34484811	hsa-mir-99a	Pancreatic Carcinoma	In situ hybridization for miR detection in the paired resected human PDAC tissues showed that miR-125b-5p and miR-99a-5p are highly expressed in inflammatory cells in the tumor stroma, located in clusters of CD79A expressing cells of the B-lymphocyte lineage. In conclusion, we found that circulating miR-125b-5p and miR-99a-5p are potential immune-cell related prognostic biomarkers in PDAC patients after surgery.
other	34484674	hsa-mir-98	Carcinoma, Hepatocellular	5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients.
other	34484674	hsa-mir-98	Breast Neoplasms	5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients.
other	34484674	hsa-mir-98	Carcinoma, Non-Small-Cell Lung	5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients.
genetics_overexpression_suppress	34484645	hsa-mir-21	Multiple Sclerosis	BACKGROUND: Overexpression of miR-21 is a characteristic feature of patients with Multiple Sclerosis (MS) and is involved in gene regulation and the expression enhancement of pro-inflammatory factors including IFNgamma and TNF-alpha following stimulation of T-cells via the T Cell Receptor (TCR).
genetics_knock down_suppress	34484334	hsa-mir-519c	Carcinoma, Hepatocellular	Moreover, miR-519c-3p overexpression stimulates HCC cell growth.
other	34484332	hsa-mir-199a	Colorectal Neoplasms	Gambogic Acid nanoparticles may influence CC cell biological behaviors by modulating miR-199a-3p, providing a novel treatment scheme for CC in the future.
exosome	34484115	hsa-mir-93	Urinary Incontinence, Stress	Our study indicates that miR-93 delivered by ADSCs-extracellular vesicles could regulate extracellular matrix remodeling of stress urinary incontinence fibroblasts and promote activation of stress urinary incontinence satellite cells through targeting F3.
transcription factor target	34483933	hsa-mir-21	Intestinal Diseases	3p could regulate the Wnt signaling pathway by targeting MTDH mRNA, suggesting the effect of miR
other	34483854	hsa-mir-24	Ischemic Stroke	3p-GPR17 may play important roles in the progression of ischemic stroke.
other	34483854	hsa-mir-93	Ischemic Stroke	3p-GPR17 may play important roles in the progression of ischemic stroke.
genetics_GWAS	34483680	hsa-mir-217	Coronary Artery Disease	Conclusion These findings highlighted the important role of genetic variants of the miR-217 gene in the pathogenesis of CAD and potential targets for intervention.
lncRNA target	34483291	hsa-mir-212	Heart Failure	Our findings demonstrated the novel molecular mechanism of GARS1-DT/miR5p/PI3K/AKT axis on the regulation of hypoxia-induced myocardial injury in H9C2 cells, which may provide potential therapeutic targets for acute myocardial infarction treatment.
genetics_overexpression_promote	34483150	hsa-mir-146a	Diabetic Foot	Overexpression of miR-146a promoted cell proliferation and migration in an in vitro DFU model and also promoted the expression of HIF-1, Wnt3a and -catenin but suppressed the expression of AKAP12.
genetics_knock down_promote	34483139	hsa-mir-24	Stomach Neoplasms	Hsa_circ_0091994 knockdown inhibited the progression of GC by inhibiting the miR
other	34483137	hsa-mir-508	Ossification of Posterior Longitudinal Ligament	In conclusion, our research shows that hsa_circ_0007292 regulates OPLL progression by the miR3p/SATB2 pathway.
other	34482860	hsa-mir-196a	Carcinoma, Non-Small-Cell Lung	Herein, by catalytic hairpin assembly as a signal amplification strategy, we designed a novel surface-enhanced Raman scattering (SERS)-lateral flow assay (LFA) strip for ultrasensitive detection of miR-21 and miR-196a-5p in non-small cell lung cancer (NSCLC) urine on a single test (T) line. The clinical feasibility of the proposed method was also evaluated by detecting the levels of miR-21 and miR-196a-5p in urine samples from NSCLC patients and healthy subjects.
other	34482860	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Herein, by catalytic hairpin assembly as a signal amplification strategy, we designed a novel surface-enhanced Raman scattering (SERS)-lateral flow assay (LFA) strip for ultrasensitive detection of miR-21 and miR-196a-5p in non-small cell lung cancer (NSCLC) urine on a single test (T) line. The clinical feasibility of the proposed method was also evaluated by detecting the levels of miR-21 and miR-196a-5p in urine samples from NSCLC patients and healthy subjects.
transcription factor target	34482798	hsa-mir-155	Lipidoses	In summary, downregulation of Salusin-beta protected HK-2 cells against HG-induced inflammation, oxidative stress, apoptosis and ameliorated lipid accumulation through suppressing miR
genetics_overexpression_promote	34482792	hsa-mir-195	Thyroid Neoplasms	Overexpression of miR
other	34482767	hsa-mir-432	Urinary Bladder Neoplasms	Conclusion: Circ-SMARCA5 high expression but miR-432 low expression is correlated with advanced tumor features and poor survival of bladder cancer patients, which present as potential prognostic markers in bladder cancer.
lncRNA target	34482528	hsa-mir-200b	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Foxo3 was a target of miR-200b-3p and ORLNC1 promoted BMSCs pyroptosis induced by CML through targeting miR-200b-3p/Foxo3 pathway.
genetics_knock down_promote	34482266	hsa-mir-155	Pancreatic Carcinoma	5p knockdown in PC cells enhanced anti-tumor immunity.
lncRNA target	34482026	hsa-mir-199b	Prostatic Neoplasms	OBJECTIVES: MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). CONCLUSION: miR-199b-3p suppresses malignant proliferation by inhibiting PLCepsilon in prostate cancer in vitro and vivo.
epigenetics	34481973	hsa-mir-34a	Osteosarcoma	Mechanistically, DI-1 repressed recruitment of DNMT-1 to the promoter region of miR-34a and, in turn, decreased the methylation rate in the promoter region of miR-34a in OSA cells.
genetics_overexpression_promote	34481934	hsa-mir-769	Stomach Neoplasms	3p targeted IGF1R and IGF1R overexpression rescued the effects of miR
exosome	34481913	hsa-mir-206	Ischemia	Collectively, exosomes from OGD HUVECs could protect neurons against ischemia-induced injuries, and the effects were associated with the suppression of RMRP in neurons via distance transfer of miR-206 and miR3p.
exosome	34481913	hsa-mir-1	Ischemia	Collectively, exosomes from OGD HUVECs could protect neurons against ischemia-induced injuries, and the effects were associated with the suppression of RMRP in neurons via distance transfer of miR-206 and miR3p.
lncRNA target	34481903	hsa-mir-138	Pulmonary Fibrosis	Collectively, we revealed that miR-138 significantly targeted ZEB2, thus inhibited the EMT process and mitigated the development of pulmonary fibrosis.
lncRNA target	34481532	hsa-mir-122	Carcinoma, Hepatocellular	MicroRNA-122 (miR-122) is a liver-specific microRNA and is closely associated with HCC metastasis, which makes miR-122 a promising target for drug design and development. The results indicated that OA attenuated the migration and invasion abilities of HCC cells by upregulating miR-122 expression.
lncRNA target	34481229	hsa-mir-1764	Tuberous Sclerosis	SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation.
lncRNA target	34481218	hsa-mir-337	Breast Neoplasms	3p is a tumor-inhibitor of BC and plays its regulatory role via its downstream gene ESRP1.
transcription factor target	34480914	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	5p could directly affect its silencing potency towards target genes, which finally impaired its promotion to proliferation and motility.
circRNA target	34480205	hsa-mir-513	Osteosarcoma	Further mechanistic studies indicated that circCRIM1 served as a competing endogenous RNA (ceRNA) of miR-513, leading to decreases in the proliferation, migration, and invasion of OS cells. Taken together, our data uncovered a significant role of the circCRIM1/miR-513 pathway in the proliferation, migration, and invasion of OS cell lines and suggested that circCRIM1 may serve as a possible therapeutic target for OS treatment.
genetics_knock down_promote	34479589	hsa-mir-216b	Colorectal Neoplasms	CONCLUSION: Circ_0029803 knockdown hindered proliferation, migration, invasion, EMT, and glycolysis and promoted apoptosis in CRC cells by modulating the miR-216b-5p/SKIL axis.
other	34479583	hsa-mir-145	Colorectal Neoplasms	5p was decreased in CRC samples compared with adjacent tissues (p < 0.05).
circulation_biomarker_diagnosis_up	34479528	hsa-mir-1290	Gastrointestinal Neoplasms	CONCLUSIONS: Our findings indicate that circulating miR-1290 is a potential biomarker for gastrointestinal cancer diagnosis and monitoring.
genetics_knock down_promote	34479497	hsa-mir-1290	Glioma	In addition, RORA was a target of miR-1290, and glioma cell malignant phenotypes promoted by miR-1290 restoration were partly blocked by RORA overexpression.
transcription factor target	34479475	hsa-mir-153	Hearing Loss, Sensorineural	As miR-153 can target and regulate KCNQ4, we sought to study the role of miR-153 in SNHL. This study demonstrates that miR-153 inhibition significantly restores KNCQ4 in cochlea after noise exposure, which attenuates SNHL.
other	34479063	hsa-mir-4535	Pregnancy Complications, Infectious	5p levels in amniotic fluid may be considered clinically predictive for foetal morbidity of infection.
other	34479063	hsa-mir-1915	Pregnancy Complications, Infectious	5p levels in amniotic fluid may be considered clinically predictive for foetal morbidity of infection.
other	34479022	hsa-mir-126	Myocardial Ischemia	CONCLUSION: In summary, YQHX improves angiogenesis by regulating the miR-126/PI3K/Akt signaling pathway, which indicates that YQHX could be a promising therapeutic strategy for ischemic myocardium.
other	34478872	hsa-mir-17	Carcinoma, Hepatocellular	miR5p upregulation was associated with MPM downregulation in HCC tissues.
genetics_overexpression_promote	34478121	hsa-mir-643	Endometritis	CircFADS2 is downregulated in endometritis, and it overexpression promotes miR-643 maturation in HEnEpCs to suppress cell apoptosis.
lncRNA target	34478013	hsa-mir-107	Glioma	CONCLUSION: Our data suggested that LINC00152 is a candidate prognostic marker of glioma, and that the LINC00152/MIR-107/RAB10 axis plays a pivotal role in regulation of the glioma malignancy, and therefore, targeting the axis might be an effective therapeutic strategy to treat glioma.
exosome	34478012	hsa-mir-490	Sepsis	Taken together, our results suggest that exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of circ-Fryl and regulation of the miR3p/SIRT3 pathway.
other	34478010	hsa-mir-1	Aortic Aneurysm, Thoracic	Moreover, miR3p was decreased, and ADAM10 was upregulated in TAA aorta tissues and VSMC.
genetics_overexpression_promote	34477918	hsa-mir-193a	Osteoporosis	Our results showed that miR-193a was overexpressed, while SIRT7 was downregulated in osteoporosis.
other	34477698	hsa-mir-181a	Ischemic Stroke	MicroRNA-181a (miR-181a) is one of the upregulated miRNAs in the ischemic brain and its downregulation can reduce the damage to the ischemic brain.
lncRNA target	34477483	hsa-mir-3690	Colorectal Neoplasms	The present results demonstrated that SNHG10 promotes colorectal cancer cells the malignant progression by targeting miR-3690.Abbreviations: CRC: Colorectal cancer; Lnc RNA: Long noncoding RNA; microRNAs: miRNAs/miRs; RT-qPCR: reverse transcription quantitative polymerase chain reaction; CCK-8: Cell Counting Kit-8.
lncRNA target	34477476	hsa-mir-20b	Colorectal Neoplasms	In CRC cells, miR-20b-5p was sponged by COL4A2-AS1 and hypoxia-inducible factor 1 alpha subunit (HIF1A). The current findings showed that COL4A2-AS1 promoted the proliferation, and aerobic glycolysis of CRC cells potentially through modulating the miR-20b-5p/HIF1A axis.
lncRNA target	34477472	hsa-mir-181a	Purpura	CONCLUSIONS: The lncRNA MEG8 sponged miR-181a-5p, which contributes to M1 macrophage polarization by regulating SHP2 expression in HSP rats.Key MessagesLncRNA MEG8 downregulation and M2 polarization in Henoch Schonlein purpura rats.MEG8 upregulation enhances M1 polarization and suppresses JAK2/STAT3 pathway.MEG8 sponges miRNA-181a-5p to regulate SHP2 expression.MiRNA-181a-5p upregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.SHP2 downregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.
other	34477137	hsa-mir-503	lung squamous cell carcinoma	AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC.
other	34477137	hsa-mir-96	lung squamous cell carcinoma	AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC.
genetics_knock down_promote	34477002	hsa-mir-2682	Carcinoma, Non-Small-Cell Lung	HDAC1 overexpression abolished the effects of miR
other	34476933	hsa-mir-183	psoriasis 1	KCNQ1OT1 promotes the proliferation and migration of psoriatic keratinocytes by regulating miR3p/GAB1.
lncRNA target	34476924	hsa-mir-216a	Bronchopneumonia	miR-216a-5p may be a valuable target for anti-inflammation treatment in bronchopneumonia.
lncRNA target	34476924	hsa-mir-216a	Respiratory Tract Infections	miR-216a-5p may be a valuable target for anti-inflammation treatment in bronchopneumonia.Bronchopneumonia is a common respiratory infection disease and is the main cause of hospitalization in children under 5 years of age.
exosome	34476508	hsa-mir-29a	Cicatrix	In summary, the current data indicated that miR29amodified hADSC exosome therapy can decrease scar formation by inhibiting the TGF2/Smad3 signaling pathway via its derived exogenous miR29a, and this may be useful for the future treatment of pathological scars by providing a potential molecular basis.
other	34476503	hsa-mir-502	Tuberculosis	The Gene Expression Omnibus database was used to analyze miR5023p expression in patients with TB and healthy individuals.
genetics_overexpression_suppress	34476503	hsa-mir-502	Light Fixation Seizure Syndrome	ROCK1 overexpression reversed the miR5023p inhibitory effect on cytokine production in M.
lncRNA target	34476497	hsa-mir-448	Colorectal Neoplasms	The findings of the present study indicated that lncRNA NEAT1 modulates IRinduced pyroptosis and viability in HCT116 cells via miR448 by regulating the expression, but not activation of GSDME.
genetics_knock down_promote	34476495	hsa-mir-93	Leukemia, Myeloid, Acute	The knockdown of miR93 in HL60 cells inhibited AML cell proliferation and resistance to apoptosis, while the overexpression of miR93 in THP1 cells led to contrasting results.
other	34476267	hsa-mir-200c	COVID-19	Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2.
other	34476004	hsa-mir-193a	Osteosarcoma	The miR-193a-5p/NCX2/AKT axis promotes invasion and metastasis of osteosarcoma.
genetics_overexpression_promote	34476001	hsa-mir-637	Thyroid Neoplasms	PANDAR negatively correlated with miR-637, and miR-637 overexpression suppressed thyroid gland carcinoma progression, which could be reversed by PANDAR.
lncRNA target	34475987	hsa-mir-1207	Glioma	3p/HNF1B signaling axis may serve as novel molecular targets for glioma prevention and treatment.
lncRNA target	34475985	hsa-mir-29b	Carcinoma, Ovarian Epithelial	Conclusions: The lncRNA-H19/miR-29b-3p axis improved carboplatin resistance of EOC by targeting STAT3, indicating a possible approach to improving chemotherapy for EOC.
genetics_knock down_suppress	34475974	hsa-mir-361	Uterine Cervical Neoplasms	Knockdown of LINC01123 inhibits cell viability, migration and invasion via miR-361-3p/TSPAN1 targeting in cervical cancer.
target gene	34475958	hsa-mir-370	Breast Neoplasms	miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5.
other	34475786	hsa-mir-223	Polycystic Ovary Syndrome	3p and NF-kappaB levels in aggravating PCOS pancreatic autophagy and consequent impairments.
transcription factor target	34475393	hsa-mir-181a	Osteoporosis	Altogether, this study demonstrated for the first time the role of miRNA-181a/DUSP6 in the progression of osteoporosis via the ERK2 and SMAD2 signaling pathway.
transcription factor target	34474856	hsa-mir-34a	Breast Neoplasms	Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment.
circulation_biomarker_diagnosis_ns	34474768	hsa-mir-208b	Atrial Fibrillation	We calculated serum levels of miR-208 b in paroxysmal and persistent AFib, embolic cerebrovascular accident patients with AFib as possible etiology and controls. There was a statistically significant change of miR-208 b levels in paroxysmal (p = 0.044) and persistent (p = 0.040) AFib patients, but not for embolic CVA patients.
circulation_biomarker_diagnosis_ns	34474460	hsa-mir-21	Glioblastoma	The antagomir-21/RAP nanoparticles were administrated intranasally in the intracranial glioblastoma animal models to bypass the blood-brain-barrier.
other	34474410	hsa-mir-107	Acute Coronary Syndrome	CONCLUSION: Platelet miR-107 participated in clopidogrel resistance in ACS/PCI patients by regulating P2Y12 expression.
genetics_knock down_suppress	34474408	hsa-mir-455	Brain Ischemia	CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis.
genetics_knock down_suppress	34474408	hsa-mir-455	Pulmonary Fibrosis	CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis.
genetics_knock down_suppress	34474408	hsa-mir-455	Inflammation	CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis.
lncRNA target	34474269	hsa-mir-750-1	Charcot-Marie-Tooth disease type 3	viridis might respond to DSP toxins through miR-750_1, novel_mir4 and miR-71_5 regulating the expression of relevant target genes involved in apoptosis, cytoskeleton, and immune response, etc.
lncRNA target	34474269	hsa-mir-71	Charcot-Marie-Tooth disease type 3	viridis might respond to DSP toxins through miR-750_1, novel_mir4 and miR-71_5 regulating the expression of relevant target genes involved in apoptosis, cytoskeleton, and immune response, etc.
genetics_knock down_promote	34474146	hsa-mir-223	Lymphoma, Mantle-Cell	3p knockdown promoted proliferation and inhibited apoptosis of MCL cells after ibrutinib treatment in vitro and vivo, whereas CHUK knockdown reversed downregulated miRNA
lncRNA target	34473845	hsa-mir-21	Rhinitis, Allergic	CONCLUSION: Lnc-GAS5 is negatively correlated with that of its targets (miR-21 and miR-140) in AR; meanwhile, lnc-GAS5, miR-21, and miR-140 are correlated with disease risk, symptom severity, and Th1/Th2 imbalance in AR, suggesting the potential of these biomarkers in the development and progression of AR.
lncRNA target	34473845	hsa-mir-140	Rhinitis, Allergic	CONCLUSION: Lnc-GAS5 is negatively correlated with that of its targets (miR-21 and miR-140) in AR; meanwhile, lnc-GAS5, miR-21, and miR-140 are correlated with disease risk, symptom severity, and Th1/Th2 imbalance in AR, suggesting the potential of these biomarkers in the development and progression of AR.
circulation_biomarker_diagnosis_ns	34472584	hsa-mir-494	Muscular Dystrophy, Duchenne	Cellular and circulating levels of miR3p had shown significant increase in symptomatic carriers, which may indicate significant roles played by this miRNA in the onset of muscular weakness.
lncRNA target	34472490	hsa-mir-615	Parkinson Disease	These findings suggest that inhibition of HOTTIP mitigates neuronal apoptosis and microglial activation in PD models by modulating miR3p/FOXO1.
genetics_knock down_suppress	34472482	hsa-mir-181c	Reperfusion Injury, Cerebral Ischemia	These findings suggest that MEG3 knockdown inhibited autophagy and alleviated cerebral ischemia/reperfusion injury through the miR-181c-5p/ATG7 signaling pathway.
circulation_biomarker_diagnosis_ns	34472480	hsa-mir-185	Brain Injuries, Traumatic	These findings suggest that circLphn3, as a molecular sponge of miR5p, regulates tight junction proteins' expression after traumatic brain injury, and it thereby improves the permeability of the blood-brain barrier.
lncRNA target	34472153	hsa-mir-378	Laryngeal Neoplasms	Interestingly, we discovered that LINC00888 functioned as an miRNA sponge to suppress the effect of miR-378g on laryngeal cancer cells behaviors, as well as positively regulate TFRC expression.
transcription factor target	34472106	hsa-mir-129	Prostatic Neoplasms	5p hindered the biological functions of cancer cells via inhibiting DLX1 expression.
other	34472046	hsa-mir-145	Glomerulonephritis, Membranous	5p-PRKG1, may be associated with MN development.
other	34472046	hsa-mir-148a	Glomerulonephritis, Membranous	5p-PRKG1, may be associated with MN development.
lncRNA target	34471998	hsa-mir-570	Colonic Neoplasms	The results proved that miR-570 could potentially function as a tumor suppressor and a potential prognostic factor in patients with colon cancer.
circRNA target	34471941	hsa-mir-195	Glioma	5p/TGIF2 axis, suggesting a promising circRNA-targeted therapy for glioma treatment.
other	34471485	hsa-mir-34a	Hirschsprung Disease	Further rescue experiments have confirmed that DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in HSCR. CONCLUSION: DRAIC promoted cell proliferation and migration by regulating the miR-34a-5p/ITGA6 signal axis in HSCR.
lncRNA target	34471374	hsa-mir-410	Neonatal Sepsis	3p was a target of NORAD and lowly expressed in the NS patients.
circulation_biomarker_diagnosis_up	34470640	hsa-mir-216b	Carcinoma, Non-Small-Cell Lung	Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC.
lncRNA target	34470587	hsa-mir-223	Glioblastoma	Eventually, rescue assays validated PITPNA-AS1 sponged miR3p to promote EGFR expression, thus activating PI3K/AKT signaling pathway to accelerate proliferation and inhibit apoptosis of GBM cells.
genetics_knock down_promote	34470585	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	Besides, circ_0060937 depletion suppressed tumor growth in vivo.Circ_0060937 knockdown hindered NSCLC development and glycolysis via regulating miR
lncRNA target	34470582	hsa-mir-192	Glioblastoma	5p and RAB2A in GBM cells was explored through pull down, luciferase reporter, and RIP assays.
lncRNA target	34470574	hsa-mir-211	Colorectal Neoplasms	Mechanistically, HOTAIR facilitated the expression of the microRNA (miR)5p target gene fms-like tyrosine kinase-1 (FLT-1), thereby modulating cancer stem cell (CSC) properties in CRC.
lncRNA target	34470571	hsa-mir-212	Fetal Growth Retardation	3p could target PGF, and the expression of both was negatively correlated in FGR group tissues.
lncRNA target	34469714	hsa-mir-124	osteogenesis imperfecta type 1	In vivo, intravitreal injection of miR3p, shMALAT1 decreased EGR1 expression and markedly suppressed retinal neovascularization in OIR models.
other	34469714	hsa-mir-124	Retinopathy of Prematurity	3p/EGR1 regulatory axis is partly responsible for retinal neovascularization, which may provide a novel theoretical basis for the pathogenesis of ROP.
transcription factor target	34469060	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	Mechanistic analyses indicated that As(4) S(4) might sensitize NSCLC cells to DDP through targeting p53/miR-34a-5p/PD-L1 axis.
exosome	34469038	hsa-mir-106a	Nasopharyngeal Carcinoma	Taken together, these findings indicate that exosomal miR-106a-5p could be a promising diagnostic biomarker and drug target for patients with NPC.
genetics_knock down_suppress	34469009	hsa-mir-515	Prostatic Neoplasms	5p silencing largely diminished circ-PAPPA knockdown-mediated effects in PCa cells.
lncRNA target	34468912	hsa-mir-944	Colorectal Neoplasms	Intriguingly, it was suggested that NP1 tackled the CRC cells through down-regulation of the H19, HOTTIP, HULC, LINC00641, miR-200, miR-92a, miR-21, YKL-40, PPARgamma, and VEGF expressions, as well as up-regulation of the miR-944 and ECN expressions.
lncRNA target	34468912	hsa-mir-21	Colorectal Neoplasms	Intriguingly, it was suggested that NP1 tackled the CRC cells through down-regulation of the H19, HOTTIP, HULC, LINC00641, miR-200, miR-92a, miR-21, YKL-40, PPARgamma, and VEGF expressions, as well as up-regulation of the miR-944 and ECN expressions.
other	34468254	hsa-mir-145	Cardiomegaly	circNfix attenuated pressure overload-induced cardiac hypertrophy by regulating the miR5p/ATF3 axis.
lncRNA target	34468207	hsa-mir-574	Pancreatic Carcinoma	3p/PIM3 axis might contribute to novel biomarker development in PC treatment.NEW & NOTEWORTHY RGMB-AS1 promotes PC cell proliferation, elevates PC cell migration capacity, inhibits PC cell apoptosis, and promotes PC cell proliferation and migration but inhibits cell apoptosis via targeting miR
lncRNA target	34468015	hsa-mir-32	pancreatic adenocarcinoma	miR325p significantly inhibited the proliferation of PAAD cells and markedly reduced migration and invasion compared with the negative controls.
circulation_biomarker_diagnosis_ns	34468014	hsa-mir-34a	Hypertension, Pulmonary	NEAT1 was not only highly expressed in the serum of PAH patients but its silencing also alleviated PAH by regulating miR34a5p/KLF4 in vitro.
transcription factor target	34468010	hsa-mir-498	Uterine Cervical Neoplasms	MIR93HG promoted the proliferation cervical cancer cells via EP300 and miR498. These in vitro and in vivo findings demonstrate the regulatory role of the MIR93HG/miR498/EP300 axis in cervical cancer cell growth.
lncRNA target	34467896	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	In vitro assays demonstrated that both miR-34a and miR-34b/c inhibits SCC cells proliferation, migration and invasion via Notch1 pathway, while miR-34b/c effects more than miR-34a does.
lncRNA target	34467896	hsa-mir-34	Carcinoma, Non-Small-Cell Lung	In vitro assays demonstrated that both miR-34a and miR-34b/c inhibits SCC cells proliferation, migration and invasion via Notch1 pathway, while miR-34b/c effects more than miR-34a does.
lncRNA target	34466494	hsa-mir-200a	Stomach Neoplasms	CONCLUSION: Our findings suggest that the miR-28 and miR-200a have tumor-suppressor functions and may be considered as potential biomarkers for gastric cancer diagnosis and prognosis.
lncRNA target	34466494	hsa-mir-28	Stomach Neoplasms	CONCLUSION: Our findings suggest that the miR-28 and miR-200a have tumor-suppressor functions and may be considered as potential biomarkers for gastric cancer diagnosis and prognosis.
other	34466154	hsa-mir-1	Colonic Neoplasms	AuNPs can increase the capacity of miR-31 quantification, representing a new strategy to develop non-invasive tools for the molecular diagnosis and monitoring of colon cancer
other	34466069	hsa-mir-144	Glomerulonephritis, IGA	Network construction ultimately lead to the identification of nine gene named FN1, EGR1, FOS, JUN, SERPINE1, MMP2, ATF3, MYC, and IL1B and one novel key miRNA namely, has-miR3p as biomarker for diagnosis and therapy of IgAN.
target gene	34465995	hsa-mir-101	Ischemic Stroke	MiR-101 Protects Against the Cerebral I/R Injury Through Regulating JAK2/STAT3 Signaling Pathway.
transcription factor target	34465878	hsa-mir-2137	Hypoxia-Ischemia, Brain	Mir-2137, -335, -137, and -376c were significantly altered by neonatal HIBI at 24 and 72h, with 3 of the 4 demonstrating multiphasic expression (different direction of differential expression at 24 versus 72h). Mir-2137, -335, -137, and -376c were significantly altered by neonatal HIBI and therefore deserve further investigation as possible therapeutic targets.
circulation_biomarker_diagnosis_up	34465793	hsa-mir-19a	Breast Neoplasms	Both exosomal miR-19a and Integrin-Binding Sialoprotein (IBSP) are found to be significantly upregulated and secreted from bone-tropic ER(+) breast cancer cells, increasing their levels in the circulation of patients.
other	34465369	hsa-mir-124	Retinitis	This shift was further demonstrated by a change in the seed binding regions of miR3p, the most abundant retinal AGO2-bound miRNA, and has known roles in regulating retinal inflammation.
genetics_overexpression_promote	34465330	hsa-mir-182	Nasopharyngeal Carcinoma	Furthermore, overexpression of miR
lncRNA target	34465322	hsa-mir-34a	Pulmonary Arterial Hypertension	Inhibition of HDAC1 alleviates pulmonary arterial remodeling and PAH through up-regulation of miR-34a level and subsequent reduction of MMP-9/TIMP-1 and MMP-2/TIMP-2, suggesting that inhibition of HDAC1 might have potential value in the management of PAH.
other	34465058	hsa-let-7	Fetal Growth Retardation	In conclusion, PCE can cause female adrenal dysfunction with matrilineal multi-generation inheritance, which is related to the programming alteration of the H19/let-7 axis.
lncRNA target	34464885	hsa-mir-532	Neurologic Manifestations	5p in IS via targeting BACH1.
lncRNA target	34464885	hsa-mir-532	Ischemic Stroke	5p in IS via targeting BACH1.
other	34464683	hsa-mir-181a	Diabetes Mellitus, Type 2	CONCLUSIONS: Our observations suggest that MSC-derived miR-181a-5p mitigates glucagon secretion of alpha-cells by regulating PTEN/AKT signaling, which provides novel evidence demonstrating the potential for MSCs in treating T2DM.
other	34464666	hsa-mir-145	Atherosclerosis	5p.
transcription factor target	34464226	hsa-mir-21	Pre-Eclampsia	Using RT-qPCR, western blot, and immunohistochemistry, it was demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 were increased. miR-21 may serve key roles in the development of preeclampsia by targeting RASA1.
other	34463892	hsa-mir-98	Stomach Neoplasms	The network directly related to PGC was as follows: SNHG16/hsa_circ_0008197-hsa-mir5p/hsa-let-7f-5 qRT-PCR validation results showed that PGC, PPARG, SNHG16, and hsa_circ_0008197 were differentially expressed in gastric cancer cells and tissues: PGC positively correlated with PPARG (r=0.276, P=0.009), SNHG16 (r=0.35, P=0.002), and hsa_circ_0008197 (r=0.346, P=0.005).
other	34463887	hsa-mir-146a	Colorectal Neoplasms	METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer.
other	34463887	hsa-mir-134	Colorectal Neoplasms	METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer.
other	34463887	hsa-mir-196	Colorectal Neoplasms	METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer.
other	34463887	hsa-mir-132	Colorectal Neoplasms	METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer.
lncRNA target	34463266	hsa-mir-145	Acquired Immunodeficiency Syndrome	CRISPR-based editing of the miRNA target site preserves CFTR mRNA and function in airway epithelial cells INTERPRETATION: Given the important roles of TGF-beta signaling and the multitude of genes regulated by miRNAs, we demonstrate that CRISPR-based gene-specific microRNA antagonism approach can preserve CFTR mRNA and function in the context of HIV Tat and TGF-beta signaling without suppressing expression of other genes regulated by miR
lncRNA target	34463266	hsa-mir-145	Cystic Fibrosis	TGF-beta signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR).
other	34463266	hsa-mir-509	Acquired Immunodeficiency Syndrome	3p.
lncRNA target	34463266	hsa-mir-145	Pulmonary Disease, Chronic Obstructive	TGF-beta signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR).
lncRNA target	34463227	hsa-mir-290	Bone Diseases	CONCLUSION: Our findings indicate that the PTH-responsive miR-290 regulated Runx2- mediated MMP-13 expression in rat osteoblastic cells, suggesting miR-290 as a molecular marker or target in bone and bone-related diseases.
lncRNA target	34463208	hsa-mir-1301	Squamous Cell Carcinoma of Head and Neck	Overall, LINC01207 promotes OSCC progression via the miR3p/LDHA axis.
genetics_overexpression_promote	34463194	hsa-mir-451	Glioma	In this study, we transfected lentivirus expressing miRNA-451 to test the effect of miRNA-451 overexpression on malignant glioma cell lines and confirmed that IKKbeta is a target gene of miRNA-451 by luciferase assay.
other	34463189	hsa-mir-126	Diabetes Mellitus	High glucose environment of diabetes can affect the adhesion of EPCs by decreasing the expression of CXC chemokine receptor 4 (CXCR4) and affect the proliferation of EPCs by decreasing the expression of miR-126.
lncRNA target	34463129	hsa-mir-183	Osteoarthritis	mediated inhibition of macrophage infiltration, and dual luciferase reporter assay demonstrated that miR-183 directly targeted TGFalpha.
other	34463003	hsa-mir-135	Breast Neoplasms	Our data suggest that EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR5p.
other	34462890	hsa-mir-191	Out-of-Hospital Cardiac Arrest	5p was down-regulated in patients with poor neurological outcomes, and it could be used as a promising novel biomarker for prediction of neurological outcome and survival after OHCA.
circRNA target	34462874	hsa-mir-424	Pre-Eclampsia	5p/NFAT5 axis, providing an underlying circRNA-targeted therapy for preeclampsia.
circRNA target	34462830	hsa-mir-135b	Arthritis, Rheumatoid	Circ_0008360 inhibited the proliferation, migration, and inflammation and facilitated apoptosis of RA-FLSs by sponging miR-135b-5p and upregulating HDAC4, providing a potential target for prevention and treatment of RA.
other	34462662	hsa-mir-21	Sepsis	Altered expression levels of miR-126 and miR-21 reflected the severity of inflammatory response and indicated levels of T lymphocyte apoptosis in septic rats.
other	34462662	hsa-mir-126	Sepsis	Altered expression levels of miR-126 and miR-21 reflected the severity of inflammatory response and indicated levels of T lymphocyte apoptosis in septic rats.
genetics_knock down_suppress	34461926	hsa-mir-876	Stomach Neoplasms	CONCLUSION: Circ-RNF111 knockdown relieved the development of GC by regulating miR
other	34461731	hsa-mir-133a	Myocardial Infarction	Here, we developed an electrochemiluminescence biosensor based on an entropy-driven strand displacement reaction (ETSD) and a tetrahedral DNA nanostructure (TDN) for the detection of the potential AMI biomarker microRNA-133a.
genetics_overexpression_promote	34461605	hsa-mir-23b	Pancreatic Carcinoma	Functional analysis showed that the overexpression of miR-23b-3p inhibited the expression of HMGB2 in PC cells and affected cell proliferation, invasion and apoptosis.
genetics_knock down_suppress	34461493	hsa-mir-19b	Fibrosis, Renal	DISCUSSION: These results provided evidence that knockdown of XIST inhibited apoptosis and inflammation of renal fibrosis via miR-19b-mediated downregulation of SOX6.
transcription factor target	34461437	hsa-mir-1207	Prostatic Neoplasms	5p inhibited the expression of PYCR1 to repress the progression of prostate cancer by inhibiting cell growth and elevating cell apoptosis.
other	34461327	hsa-mir-27a	Concussion, Sports-Related	A single ratio (miR-27a-5p/miR-30a-3p) displayed the highest accuracy (AUC=0.810, sensitivity=82.4%, specificity=73.3%) for differentiating concussed and non-concussed participants.
lncRNA target	34460893	hsa-mir-181b	Community-Acquired Pneumonia	This study aims to evaluate the clinical significance of miR-181b in SCAP, which has been revealed to be dysregulated in acute respiratory distress syndrome events due to SCAP.
genetics_knock down_promote	34460438	hsa-mir-149	Squamous Cell Carcinoma of Head and Neck	Knockdown of lncRNA GACAT1 and transfection with miR-149 inhibitor reversed the effect of GACAT1 silencing on OSCC cells.
lncRNA target	34460057	hsa-mir-493	Glioma	5p has been identified as a tumor inhibitor to suppress the progressions of several tumors while its role in gliomas remains unknown.
genetics_knock down_promote	34460046	hsa-mir-1200	Glioma	Besides that, rescue assay suggested that circ_0000215 attenuated the inhibitory effects of sevoflurane on glioma cell growth and metastasis, which were reversed by miR-1200 overexpression or NCR3LG1 knockdown.
lncRNA target	34459789	hsa-mir-384	Glioma	CONCLUSION: LINC01087 is highly expressed in glioma and can participate in the growth of glioma through miR-384/Bcl-2 axis.
exosome	34459668	hsa-mir-146a	Wounds and Injuries	Objective: To investigate the effect of MicroRNA-146a modified adipose-derived stem cell exosomes on the proliferation and migration of fibroblasts and the therapeutic effect on wound healing. Conclusions: MicroRNA-146a modified adipose stem cell exosomes could regulate the expression of SERPINH1 and p-ERK, promote the migration and proliferation of fibroblasts, and neovascularization to promote the wound healing of rat back.
genetics_knock down_promote	34459457	hsa-mir-1179	Stomach Neoplasms	MiR-1179 was a direct target of circ_0000592, and circ_0000592 silencing-mediated effects in GC cells were partly reversed by the knockdown of miR-1179.
exosome	34459455	hsa-mir-577	Colorectal Neoplasms	Circ_0007334 and KLF12 were increased, and miR-577 was decreased in CRC tissues and cells. These results presented that circ_0007334 deficiency exerts a tumor-suppressor by the miR-577/KLF12 axis in CRC, and indicated that exosomal circ_0007334 could hinder CRC tumor growth and angiogenesis in vivo.
lncRNA target	34459454	hsa-mir-194	psoriasis 1	PF controls the proliferation and migration of psoriatic HaCat cells via the NEAT1/miR
genetics_overexpression_suppress	34459452	hsa-mir-143	Leukemia	3p repressed viability and proliferation of AML cells and overexpression of KAT6A partially reversed the inhibitory effects of miR
genetics_knock down_suppress	34459233	hsa-mir-96	Cardiomyopathies	This study investigated the functional mechanism of exosomal microRNA-96 (miR-96) derived from bone marrow mesenchymal stem cells (BMSCs) in myocardial toxicity induced by doxorubicin. Rac1 inhibition could downregulate the expression of the nuclear factor-kappaB signaling and further reverse the promotion of miR-96 knockdown on doxorubicin-induced myocardial toxicity.
genetics_overexpression_promote	34459207	hsa-mir-455	Carcinoma, Hepatocellular	PPM1F overexpression offsets the inhibitory effect of miR
exosome	34459124	hsa-mir-205	Prostatic Neoplasms	NEAT1 shuttled by PCa-derived exosomes could be transferred into hBMSCs, where NEAT1 exerted inductive properties in osteogenic differentiation of hBMSCs through the upregulation of RUNX2 by competitively binding to miR
circulation_biomarker_diagnosis_ns	34459123	hsa-mir-485	Fibrosis, Atrial	CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition.
circulation_biomarker_diagnosis_ns	34459123	hsa-mir-485	Inflammation	CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition.
circulation_biomarker_diagnosis_ns	34459123	hsa-mir-485	Atrial Fibrillation	CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition.
transcription factor target	34459097	hsa-mir-497	Parkinson Disease	In conclusion, silencing of miR5p alleviates PD by suppressing cell apoptosis and promoting autophagy in a FGF2 dependent manner, which will provide a novel target for Parkinson's disease management.
other	34458512	hsa-mir-9	Chanarin-Dorfman Syndrome	In both CMS animals and primary neurons, decreased miR5p levels were associated with dendritic simplification, while treatment with ketamine completely rescued the changes.
other	34458512	hsa-mir-9	congenital myasthenic syndrome 6	5p changes, REST protein expression levels were remarkably increased in both CMS vulnerable animals and corticosterone-treated neurons, while ketamine completely abolished this alteration.
other	34458512	hsa-mir-9	Anhedonia	5p expression inversely correlated with the anhedonic phenotype.
lncRNA target	34458374	hsa-mir-1	Stroke	Compared with the model group, the neurological impairment score, cerebral infarct size, and volume were significantly increased in the miR-1 mimic group and significantly decreased in the miR-1 inhibitor group (p < 0.05).
target gene	34458282	hsa-mir-216	Colorectal Neoplasms	Isoflurane Suppresses Proliferation, Migration, and Invasion and Facilitates Apoptosis in Colorectal Cancer Cells Through Targeting miR-216.
other	34458143	hsa-mir-96	Colorectal Neoplasms	miRNA-96-5p expression is an important factor affecting the radiation response of colorectal cancer cells.
lncRNA target	34458001	hsa-mir-132	Liver Cirrhosis	Therapeutic inhibition of miR-132 might be a new approach to alleviate liver fibrosis, and treatment efficacy can be monitored by observing EV shedding.
epigenetics	34457998	hsa-mir-5088	Breast Neoplasms	5p was upregulated by hypomethylation of its promoter, promoted by Fyn, and was involved in malignancy in breast cancer.
other	34457199	hsa-mir-16	Colorectal Neoplasms	The miR-15b, miR-16, and miR-21 panel was used to discriminate the colorectal adenoma group and CRC group with a sensitivity and specificity of 85.19% and 82.09%, respectively.
circulation_biomarker_diagnosis_up	34457199	hsa-mir-15b	Colorectal Neoplasms	AIM: To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs (miRNAs) (miR-15b, miR-16, miR-21, and miR-31) that were demonstrated to have potential diagnostic value in serum.
circulation_biomarker_diagnosis_up	34457199	hsa-mir-21	Colorectal Neoplasms	AIM: To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs (miRNAs) (miR-15b, miR-16, miR-21, and miR-31) that were demonstrated to have potential diagnostic value in serum.
other	34457197	hsa-mir-1269a	Esophageal Squamous Cell Carcinoma	CONCLUSION: miR-1269a can be used as a potential indicator for the prognosis of ESCA patients.
lncRNA target	34457116	hsa-mir-206	Breast Neoplasms	The LINC00276&MALAT1/miR-206/FZD4-Wnt7b pathway was also identified which may be useful in future research on targets against breast cancer metastasis and recurrence.
lncRNA target	34457116	hsa-mir-206	Stroke	The LINC00276&MALAT1/miR-206/FZD4-Wnt7b pathway was also identified which may be useful in future research on targets against breast cancer metastasis and recurrence.
other	34457087	hsa-mir-136	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Collectively, PSMA3-AS1 as a risk factor facilitated malignant behaviors of OSCC cells, related to the miR5p/FN1 axis.
therapeutic target	34457064	hsa-mir-212	Lymphoma	miR-212-3p may serve as a novel therapeutic target and marker for lymphoma.
target gene	34457004	hsa-mir-651	Carcinoma, Hepatocellular	miR-651-3p Enhances the Sensitivity of Hepatocellular Carcinoma to Cisplatin via Targeting ATG3-Mediated Cell Autophagy.
genetics_overexpression_promote	34456631	hsa-mir-34b	Osteosarcoma	Cooverexpressing miR-34b-3p with HCG9 partially suppressed the HCG9-stimulated proliferation, migration, and invasion of osteosarcoma cells in vitro and delayed the tumor progression in vivo. CONCLUSION: We discovered that lncRNA HCG9 promoted the proliferation of osteosarcoma cells via suppressing miR-34b-3p.
transcription factor target	34456629	hsa-mir-489	Sepsis	In conclusion, this study presented that Cur prevented GF-triggered renal injury by restraining aerobic glycolysis via the miR-489/LDHA axis in the HEK-293 cell model.
genetics_knock down_promote	34456589	hsa-mir-432	Colorectal Neoplasms	CONCLUSION: The results supported the hypothesis that circDUSP16 knockdown suppressed CRC progression by regulating the miR
other	34456588	hsa-mir-126	Ovarian Neoplasms	The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression
other	34456588	hsa-mir-199a	Ovarian Neoplasms	The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression
other	34456588	hsa-mir-199b	Ovarian Neoplasms	The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression
other	34456588	hsa-mir-145	Ovarian Neoplasms	The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression
other	34456585	hsa-mir-138	Ischemic Stroke	3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases.
other	34456585	hsa-mir-9	Ischemic Stroke	3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases.
other	34456585	hsa-mir-651	Ischemic Stroke	3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases.
genetics_overexpression_suppress	34456566	hsa-mir-23a	Glioblastoma	The effects of circPTK2 overexpression on miR-23a maturation were analyzed by transfecting circPTK2 expression vector into glioblastoma cells, followed by determining the expression of mature miR-23a and premature miR-23a by RT-qPCR.
other	34456284	hsa-mir-96	Osteoporosis	In addition, the expression of MALAT1 significantly decreased whereas that of miR-96 increased in the hBMSCs of osteoporosis (OP) patients.
other	34456284	hsa-mir-96	Adenocarcinoma of Lung	OBJECTIVES: To investigate whether and how the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponges microRNA-96 (miR-96) to achieve the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). Metastasis-associated lung adenocarcinoma transcript 1, miR-96, and osteogenesis-related Messenger RNA expression was assessed by Quantitative Real-time Polymerase Chain Reaction (qRT-PCR).
other	34456284	hsa-mir-96	Osteoporosis-pseudoglioma syndrome	In addition, the expression of MALAT1 significantly decreased whereas that of miR-96 increased in the hBMSCs of osteoporosis (OP) patients.
genetics_knock down_suppress	34455968	hsa-mir-152	Carcinoma, Non-Small-Cell Lung	3p expression and that the knockdown of PCGEM1 may inhibit NSCLC cell proliferation, migration and invasion by sponging miR
lncRNA target	34455918	hsa-mir-340	Squamous Cell Carcinoma of Head and Neck	Taken together, circPPFIA1 promotes the progression of LSCC via the miR3p/ELK1 signaling axis, which may serve as a novel prognostic or therapeutic target for LSCC.
target gene	34455899	hsa-mir-153	Breast Neoplasms	the miRNA-153 inhibited breast cancer growth via regulation of mTORC2 signaling pathway
other	34455717	hsa-mir-11181	Glioblastoma	RESULTS: RT-qPCR analysis indicated that both Hsa-miR5p and Has-miR11181-3p specifically up-regulated in higher grades of glioma tumours versus other brain tumour types.
transcription factor target	34455717	hsa-mir-1118	Glioblastoma	Due to the high expression of Hsa-miR-11181 in limited glioblastoma brain tumours, in this study we intend to assess the expressions of Hsa-miR-11181 and Has-miR11181-3p in brain tumour tissues and attribute new target genes to these miRNAs.
exosome	34455417	hsa-mir-15a	Carcinoma, Hepatocellular	Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4.
lncRNA target	34455220	hsa-mir-148a	Stomach Neoplasms	CONCLUSION: The study clarified that miR-148a-3p suppressed gastric cancer tumorigenesis by inhibiting CEMIP, which may be effective targets for the clinical treatment of gastric cancer.
other	34455196	hsa-mir-374b	Leukemia, Lymphocytic, Chronic, B-Cell	5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression.
other	34455196	hsa-mir-98	Leukemia, Lymphocytic, Chronic, B-Cell	5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression.
other	34455196	hsa-mir-32	Leukemia, Lymphocytic, Chronic, B-Cell	5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression.
lncRNA target	34455059	hsa-mir-138	Alzheimer Disease	5p, providing a possible target for the treatment of diseases characterized by a cognitive deficit.
genetics_GWAS	34455057	hsa-mir-5007	Pulmonary Disease, Chronic Obstructive	rs2997119 was associated with the increased risk of COPD in women under multiple genetic models; miR
genetics_GWAS	34455057	hsa-mir-8079	Pulmonary Disease, Chronic Obstructive	CONCLUSION: Our results suggested that the genetic polymorphisms of miR-8079 or miR-5007 were potentially associated with COPD risk, of which miR
genetics_overexpression_suppress	34454812	hsa-mir-31	Melanoma	3p inhibitor and EPHA2 overexpression reversed the inhibitory effect of circ_0062270 silencing on melanoma progression.
genetics_overexpression_promote	34454554	hsa-mir-425	Ovarian Neoplasms	5p up-regulation has been proved to partially reverse the tumor suppressive function of MSC-AS1 overexpression CONCLUSION: MSC-AS1 sponged miR
other	34454450	hsa-mir-503	Carcinoma, Non-Small-Cell Lung	The interaction between DLGAP1-AS2 and miR-503 was confirmed by dual luciferase reporter assay, and their relationship was explored in NSCLC cells transfected with DLGAP1-AS2 expression vector or miR-503 mimic. CONCLUSIONS: DLGAP1-AS2 may regulate miR-503/cyclin D1 to promote cell proliferation in NSCLC.
other	34454204	hsa-let-7f	Amyotrophic Lateral Sclerosis	Furthermore, the levels of Let7f-5p, although were generally lowered in ALS patients but were also decreased in familial cases as well as in spinal onset ALS as compared to bulbar onset.
lncRNA target	34454184	hsa-mir-665	Tuberculosis	Overall, the preceding observations clearly illuminated that MIAT was elevated in human macrophage response to BCG infection, and functioned as a negative regulator in autophagy and antimicrobial effects by manipulating miR-665/ULK1 axis during Mtb infection, which may provide a promising target for developing an anti-bacterial against TB.
other	34453920	hsa-mir-638	Colorectal Neoplasms	CONCLUSION: Our current findings identified the circ-PABPN1/miR-638/SRSF1 axis as a novel anti-tumor mechanism of propofol in CRC, providing a new rationale for developing propofol as a promising therapeutic agent for CRC.
transcription factor target	34453780	hsa-mir-92a	Colorectal Neoplasms	In conclusion, RBM38 inhibits CRC progression by competitively binding to PTEN 3'UTR with miR-92a-3p.
tissue_expression_ns	34453499	hsa-mir-140	Adenocarcinoma of Lung	Upexpression of LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG and downexpression of miR
transcription factor target	34453123	hsa-mir-548ac	Leukemia, Myeloid, Acute	Taken together, these results indicated that miR-548ac delivered by AML cell-derived EVs inhibits hematopoiesis via TRIM28-dependent STAT3 activation.
circulation_biomarker_diagnosis_ns	34453104	hsa-mir-132	Fatty Liver	Reduction of miR-132 may be a target for the regulation of liver lipid homeostasis and control of obesity-related blood pressure.
circulation_biomarker_diagnosis_ns	34453104	hsa-mir-132	Obesity	Reduction of miR-132 may be a target for the regulation of liver lipid homeostasis and control of obesity-related blood pressure.
lncRNA target	34453038	hsa-mir-613	Breast Neoplasms	The functional roles of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ)-DAAM1 axis and their regulator microRNA-613 (miR-613) in BrCa cells and associated molecular mechanisms were demonstrated in vitro. Moreover, miR-613 directly targeted both YWHAZ and DAAM1, contributing to inhibiting BrCa cells migration via blocking the complex of YWHAZ-DAAM1.
genetics_overexpression_promote	34452887	hsa-mir-643	Stomach Neoplasms	Moreover, TXNDC9 overexpression reversed the effects of miR-643 mimics on gastric cancer cell viability, invasion, and migration.
genetics_overexpression_promote	34452076	hsa-mir-603	Glioblastoma	miR-603 was complexed with PEI, a cationic polymer, and encapsulated into liposomes decorated with polyethylene glycol (PEG) and PR_b, a fibronectin-mimetic peptide that specifically targets the alpha(5)beta(1) integrin that is overexpressed in glioblastomas.
genetics_GWAS	34450377	hsa-mir-421	Pancreatic Carcinoma	CONCLUSION: We found an interesting finding that the 73-03 in combination with GCB can improve GCB efficacy and decrease PCa resistance, which induced apoptosis and mitochondrial damage through epigenetic inhibition of SPINK1 transcription by miR-421 up-regulation.
other	34450025	hsa-mir-218	Motor Neuron Disease	A non-linearly responsive regulon exhibited a steep miR-218 dose-dependent threshold in repression that, when crossed, resulted in severe motor neuron synaptic failure and death.
circRNA target	34449947	hsa-mir-29	Rift Valley Fever	Therefore, circFAM120A modulated decidualization in RIF through the miR-29/ABHD5 axis.
transcription factor target	34449670	hsa-mir-203	Triple Negative Breast Neoplasms	We have identified that miRNA-203, silenced by epithelial-mesenchymal transition (EMT), is a tumor suppressor and can promote differentiation of breast cancer stem cells. In this study, we tested the ability of liposomal delivery of miR-203 to reverse aspects of breast cancer pathogenesis using breast cancer and EMT cell lines.
genetics_GWAS	34449560	hsa-mir-22	Myelodysplastic Syndromes	In summary, the loss of TET2 function, including both TET2 mutation and high miR-22 expression, was not a good biomarker for predicting the response to HMT but may be associated with lower-risk disease based on IPSS, lower leukemic transformation and longer survival.
genetics_GWAS	34449559	hsa-mir-155	Pre-Eclampsia	mir155 can be considered to be one of the genetic biomarkers and can be used as a diagnostic tool for the early detection of PE.
genetics_GWAS	34449559	hsa-mir-155	Chronic Periodontitis	mir155 can be considered to be one of the genetic biomarkers and can be used as a diagnostic tool for the early detection of PE.
other	34449141	hsa-mir-181a	Seizures, Febrile	Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients.
other	34449141	hsa-mir-155	Seizures, Febrile	Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients.
other	34449141	hsa-mir-146a	Seizures, Febrile	Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients.
circulation_biomarker_diagnosis_up	34448795	hsa-mir-146a	Osteoarthritis	CONCLUSION: The expression levels of plasma miR-146a, miR-365 and inflammatory factors are notably higher, the disease is more severe, and the function of knee joint movement is weaker in OA patients than those in healthy controls.
circulation_biomarker_diagnosis_up	34448795	hsa-mir-365	Osteoarthritis	CONCLUSION: The expression levels of plasma miR-146a, miR-365 and inflammatory factors are notably higher, the disease is more severe, and the function of knee joint movement is weaker in OA patients than those in healthy controls.
genetics_overexpression_promote	34448661	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	Overexpression of SNHG7 or miR-34a-5p inhibitor promoted NSCLC cell proliferation and accelerated tumor cell growth and metastasis.
lncRNA target	34448644	hsa-mir-200b	Asthma	NEAT1 acted as the role of sponge for miR-200a/b to regulate MMP-16 expression, thereby promoting asthma progression, suggesting that NEAT1 might have great potential as therapeutic target for asthma.
lncRNA target	34448644	hsa-mir-200a	Asthma	NEAT1 acted as the role of sponge for miR-200a/b to regulate MMP-16 expression, thereby promoting asthma progression, suggesting that NEAT1 might have great potential as therapeutic target for asthma.
circulation_biomarker_diagnosis_up	34448533	hsa-mir-181a	Pancreatitis	Expression patterns of MALAT1, microRNA-181a-5p (miR-181a-5p) and high-mobility group box 1 protein (HMGB1) in serum of AP patients were determined.
circulation_biomarker_diagnosis_ns	34448266	hsa-mir-339	Airway Obstruction	Increasing miR-339 (above the 0.02 fold change) and galectin-3 (above the 11.7 ng/ml) threshold plasma levels in lung recipients is associated with high risk (RR = 7.14 /- 0.97 [95% CI 1.05-48.60], P = 0.045) of airway obstruction after LTx.
genetics_knock down_suppress	34448115	hsa-mir-4429	Colonic Neoplasms	5p hindered colon cancer cell proliferation, migration, and invasion, whereas knockdown of miR
other	34447534	hsa-mir-155	Carcinoma, Non-Small-Cell Lung	Moreover, this nanosensor can accurately quantify miRNA-155 even at the single-cell level, and it can distinguish the miRNA-155 expression in tissues of healthy persons and nonsmall cell lung cancer (NSCLC) patients.
genetics_overexpression_suppress	34447471	hsa-mir-195a	Laryngeal Neoplasms	Collectively, the findings of the present study demonstrated that the overexpression of miR
genetics_overexpression_suppress	34447471	hsa-mir-195	Laryngeal Neoplasms	Collectively, the findings of the present study demonstrated that the overexpression of miR
transcription factor target	34447470	hsa-mir-590	Myocardial Ischemia	In summary, the present study showed that miR3p exhibited a protective effect on H/R-induced cardiomyocyte injury and may be a novel target for the treatment of myocardial ischemia disease.
other	34447464	hsa-mir-374a	Osteoporosis	Overall, findings of the present study suggested that LINC00899 could facilitate the osteogenic differentiation of hBMSCs and prevent osteoporosis by sponging miR-374a to enhance the expression of RUNX2, which provide a potentially useful therapeutic strategy for patients with osteoporosis.
lncRNA target	34446806	hsa-mir-125a	Hypogonadism	In conclusion, MIR22HG up-regulated NDRG2 expression through targeting miR-125a-5p, thus promoting LC apoptosis in LOH.
lncRNA target	34446703	hsa-mir-629	Breast Neoplasms	Therefore, our findings reveal the MIR22HG-dependent inhibition of breast cancer cell proliferation and migration via the miR5p/LATS2 pathway, providing new insights and identifying novel therapeutic targets for breast cancer treatment.
other	34446693	hsa-mir-206	Non-alcoholic Fatty Liver Disease	Circ_0057558 acts as a miR-206 sponge to de-repress the ROCK1/AMPK signaling and facilitates lipogenesis and TG secretion, which greatly contributes to NAFLD development and progression.
lncRNA target	34446576	hsa-mir-377	Lung Neoplasms	5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy.
lncRNA target	34446576	hsa-mir-155	Lung Neoplasms	5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy.
other	34446467	hsa-mir-26a	Asthma	CONCLUSION: Collectively, we identified miR-125b-5p, miR3p and miR-26a-5p as potential regulators that could contribute to the pathogenesis of asthma.
lncRNA target	34446134	hsa-mir-20a	Stomach Neoplasms	Bioinformatics was used via differential expression analysis, weighted gene co-expression network analysis, gene set enrichment analysis, and a training support vector machine (SVM) model to construct a TSIX/mir-320a/Rad51 network as the research index of GAC disease. TSIX/miR-320a/Rad51 network may be a potential biological target of GAC disease and provides a new strategy for treating GAC disease.
other	34446131	hsa-mir-92a	Acute Lung Injury	miRNA-92a (miR92a) is induced in the lungs of ALI patients and mediates inflammatory reactions. In this study, a RP1-linked R3V6 (RP1R3V6) peptide was synthesized and evaluated as a carrier of anti-microRNA-92a oligonucleotide (AMO92a) into the lungs of an ALI animal model.
lncRNA target	34446088	hsa-mir-135a	Inflammation	CONCLUSIONS: In conclusion, CASC2 alleviated proliferation, inflammation and fibrosis in DN cell model by sponging miR-135a-5p to induce TIMP3 expression.
lncRNA target	34446088	hsa-mir-135a	Diabetic Nephropathies	CONCLUSIONS: In conclusion, CASC2 alleviated proliferation, inflammation and fibrosis in DN cell model by sponging miR-135a-5p to induce TIMP3 expression.
other	34445994	hsa-mir-29b	Carcinoma, Hepatocellular	miR-29b/c-CCNA2 axes served as molecular stimuli for HCC advance.
other	34445994	hsa-mir-29c	Carcinoma, Hepatocellular	miR-29b/c-CCNA2 axes served as molecular stimuli for HCC advance.
other	34445712	hsa-mir-377	Heart Failure	Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure.
lncRNA target	34445350	hsa-mir-181b	Cerebral Intraventricular Hemorrhage	Furthermore, human choroid plexus epithelial cells (HCPEpiCs) were incubated with IVH and non-IVH CSF (10 v/v %) for 24 h in vitro to investigate the IVH-induced inflammatory response that was investigated via: (i) HMOX1, IL8, VCAM1, and ICAM1 mRNAs as well as miR-155, miR-223, and miR-181b levels by RT-qPCR; (ii) nuclear translocation of the NF-kappaB p65 subunit by fluorescence microscopy; and (iii) reactive oxygen species (ROS) measurement. IVH-III with higher miR-155 and miR-181b expression at days 41-60.
lncRNA target	34445350	hsa-mir-155	Cerebral Intraventricular Hemorrhage	Furthermore, human choroid plexus epithelial cells (HCPEpiCs) were incubated with IVH and non-IVH CSF (10 v/v %) for 24 h in vitro to investigate the IVH-induced inflammatory response that was investigated via: (i) HMOX1, IL8, VCAM1, and ICAM1 mRNAs as well as miR-155, miR-223, and miR-181b levels by RT-qPCR; (ii) nuclear translocation of the NF-kappaB p65 subunit by fluorescence microscopy; and (iii) reactive oxygen species (ROS) measurement. IVH-III with higher miR-155 and miR-181b expression at days 41-60.
other	34445337	hsa-mir-126	Pulmonary Fibrosis	Over-expression of miR3p reduces EndMT, therefore, it could be considered for miRNA-based therapeutics in fibrotic organs.
lncRNA target	34445304	hsa-mir-326	Diabetes Mellitus	The repression of Srrm4 expression is presumably mediated via a higher expression of miR
lncRNA target	34445304	hsa-mir-3547	Diabetes Mellitus	The repression of Srrm4 expression is presumably mediated via a higher expression of miR
genetics_overexpression_promote	34445087	hsa-mir-1	Mouth Neoplasms	Overexpression of MIR31HG and of miR-31 occurs during oral squamous cell carcinoma (OSCC).
other	34443415	hsa-mir-34a	Uterine Cervical Neoplasms	The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model.
other	34443215	hsa-mir-126	Periodontitis	The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis.
other	34443215	hsa-mir-126	Coronary Artery Disease	The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis.
other	34443215	hsa-mir-146a	Coronary Artery Disease	The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis.
other	34443215	hsa-mir-146a	Periodontitis	The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis.
genetics_GWAS	34442609	hsa-mir-1	Colorectal Neoplasms	Patients with CRC that had unmethylation of MLH1 and MSH2 showed significantly higher buffy coat ctKRAS G12D mutations, ascites ctKRAS G12D mutations, miR5, and mixed scores than the patients with a methylation of MLH1 and MSH2.
other	34442460	hsa-let-7a	Breast Neoplasms	3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes.
other	34442460	hsa-mir-100	Breast Neoplasms	3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes.
other	34442460	hsa-mir-101	Breast Neoplasms	3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes.
other	34442460	hsa-mir-199a	Breast Neoplasms	3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes.
other	34441345	hsa-mir-196b	Precancerous Conditions	CONCLUSION: Salivary miR-196b could be an excellent biomarker for diagnosing OPC and early detection of HNSC.
other	34441345	hsa-mir-196b	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Salivary miR-196b could be an excellent biomarker for diagnosing OPC and early detection of HNSC.
transcription factor target	34440920	hsa-mir-193a	Prostatic Neoplasms	Taken together, these findings support evidence that CK induces apoptosis via the activation of miR193a-5p and inhibition of PD-L1 and STAT3 signaling in prostate cancer cells.
lncRNA target	34440873	hsa-mir-135a	Infertility, Female	Taken together, our study reveals a pro-survival mechanism of ESR2/miR-135a/Tgfbr1/Ccnd2 axis for GC growth, and also provides a novel target for the improvement of female fertility.
lncRNA target	34440860	hsa-mir-34a	Lung Neoplasms	However, miR-34a-5p mediated targeting of these molecular networks will provide a better therapeutic intervention for NSCLC.
other	34440834	hsa-mir-193a	Colorectal Neoplasms	Hence, in the present study, the underlying apoptotic mechanism of Morusin was explored in association with miR193a-5p mediated ZNF746/c-Myc signaling axis in colorectal cancer cells (CRCs).
other	34440757	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy.
other	34440757	hsa-mir-98	Carcinoma, Non-Small-Cell Lung	In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy.
other	34440757	hsa-mir-26a	Carcinoma, Non-Small-Cell Lung	In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy.
other	34440757	hsa-mir-202	Carcinoma, Non-Small-Cell Lung	In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy.
other	34440757	hsa-let-7c	Carcinoma, Non-Small-Cell Lung	In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy.
other	34440664	hsa-mir-24	Diabetes Mellitus, Type 2	CONCLUSIONS: We suggest that GA decreases TRPM6 expression mediated by the elevation of ROS and miR3p in renal tubular epithelial cells of T2D.
other	34440625	hsa-mir-29b	Carcinoma, Pancreatic Ductal	We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues.
other	34440625	hsa-mir-7	Carcinoma, Pancreatic Ductal	We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues.
other	34440625	hsa-mir-100	Carcinoma, Pancreatic Ductal	5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels.
other	34440625	hsa-mir-145	Carcinoma, Pancreatic Ductal	5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels.
other	34440625	hsa-mir-29c	Carcinoma, Pancreatic Ductal	5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels.
other	34440625	hsa-mir-29a	Carcinoma, Pancreatic Ductal	We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues.
lncRNA target	34440380	hsa-mir-424	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
lncRNA target	34440380	hsa-mir-200c	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
lncRNA target	34440380	hsa-mir-138	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
lncRNA target	34440380	hsa-mir-570	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
lncRNA target	34440380	hsa-mir-34a	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
lncRNA target	34440380	hsa-mir-497	Triple Negative Breast Neoplasms	5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells.
other	34440358	hsa-let-7a	Fabry Disease	RESULTS: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. CONCLUSION: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients.
other	34440358	hsa-let-7d	Fabry Disease	RESULTS: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. CONCLUSION: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients.
other	34440258	hsa-mir-122	Cardiovascular Diseases	5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s).
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-375	Cardiovascular Diseases	Levels of circulating miRs (miR
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-133b	Cardiovascular Diseases	Levels of circulating miRs (miR
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-134	Cardiovascular Diseases	Levels of circulating miRs (miR
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-499	Cardiovascular Diseases	Levels of circulating miRs (miR
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-34a	Cardiovascular Diseases	Levels of circulating miRs (miR
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-208b	Cardiovascular Diseases	Levels of circulating miRs (miR
other	34440258	hsa-mir-1	Cardiovascular Diseases	5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s).
circulation_biomarker_diagnosis_ns	34440258	hsa-mir-124	Cardiovascular Diseases	Levels of circulating miRs (miR
other	34440258	hsa-mir-16	Cardiovascular Diseases	5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s).
circulation_biomarker_diagnosis_ns	34440128	hsa-mir-33a	Carotid Stenosis	Methods: In human carotid stenosis arterial tissues and plasma, the expression of ABCA1 and its target miRNAs (miRNA-33a-5p, 33b-5p, and 148a-3p) were evaluated by quantitative real time-polymerase chain reaction (qRT-PCR), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Conclusions: Therefore, miRNA-33a-5p, 33b-5p, and 148a-3p represent possible biomarkers of carotid artery stenosis by directly targeting ABCA1.
circulation_biomarker_prognosis_ns	34440094	hsa-mir-21	Carcinoma, Hepatocellular	We aim at evaluating miR-21 and miR-122 in HCC patients treated with drug-eluting beads transarterial chemoembolization (DEB-TACE) as prognostic biomarkers and investigating their correlation with hypoxia inducible factor-1alpha (HIF-1alpha) serum levels.
other	34440094	hsa-mir-122	Carcinoma, Hepatocellular	"RESULTS: The highest level of miR-21 was found in cirrhotics, while HCC patients had the highest level of miR-122 (which was even higher in ""viral"" HCC, p = 0.006)."
other	34440082	hsa-mir-6803	Obesity	3p negatively and all obesity indicators positively.
circulation_biomarker_diagnosis_ns	34440064	hsa-mir-145	Hypertension	These drugs appear to be able to modify miRs 221/222 and miR-145 expression in drug-nave hypertensives, making it closer to that of control subjects; additionally, this provides a good blood pressure compensation, contributing to slow the progression of vascular damage.
circulation_biomarker_diagnosis_ns	34440064	hsa-mir-222	Hypertension	These drugs appear to be able to modify miRs 221/222 and miR-145 expression in drug-nave hypertensives, making it closer to that of control subjects; additionally, this provides a good blood pressure compensation, contributing to slow the progression of vascular damage.
circulation_biomarker_diagnosis_ns	34440025	hsa-mir-133a	Lung Neoplasms	Cancer and lung-cancer-enriched pathways were significantly associated with the three miRNAs; in addition, nicotinate/nicotinamide metabolism, inflammation, and pulmonary hypertension were associated with miR-133a-3p. Our findings highlight how cigarette smoking affects the reliable identification of circulating miRNAs as diagnostic biomarkers in lung cancer and suggest a smoking-dependent pathogenic role of miR-133a-3p in smokers.
other	34440025	hsa-mir-532	Lung Neoplasms	3p discriminated AD/CS+ patients from H/CS+ controls (AUC: 0.779), and miR-133a discriminated AD/CS+ patients from H/CS+ controls with the highest AUC of 0.935.
other	34440025	hsa-mir-25	Lung Neoplasms	3p discriminated AD/CS+ patients from H/CS+ controls (AUC: 0.779), and miR-133a discriminated AD/CS+ patients from H/CS+ controls with the highest AUC of 0.935.
genetics_knock down_promote	34439496	hsa-mir-29a	Osteoporosis	Taken together, miR-29a promotes Oxr1, compromising oxidative stress and FoxO3 loss to delay osteoblast aging and bone loss.
exosome	34439276	hsa-mir-21	Esophageal Squamous Cell Carcinoma	Esophageal Cancer-Derived Extracellular Vesicle miR-21-5p Contributes to EMT of ESCC Cells by Disorganizing Macrophage Polarization.
other	34439151	hsa-mir-200c	Biliary Tract Neoplasms	In this study, we explored the influence of the EMT-regulating miR-200c-3p on cisplatin sensitivity in biliary tract cancer cells. In conclusion, miR-200c-3p might be an important contributor to cisplatin resistance in biliary tract cancer, independently of its interaction with ZEB1.
lncRNA target	34438465	hsa-mir-515	Colorectal Neoplasms	CONCLUSIONS: circ_0040809 facilitates CRC cell proliferation and migration, and inhibits apoptosis, through modulating miR
transcription factor target	34438336	hsa-mir-26a	osteogenesis imperfecta type 1	This study aimed to identify the role of miR-26a in osteoclastogenesis and orthodontically induced inflammatory root resorption(OIIRR). CONCLUSION: We concluded that Runx1/miR-26a/Jagged1 signaling axis restrained osteoclastogenesis and alleviated OIIRR.
genetics_overexpression_suppress	34438336	hsa-mir-26a	Otitis Media	Furthermore, miR-26a overexpression inhibited the osteoclastogenesis and rescued the root resorption in OTM rats through inhibition of Jagged1.
other	34438336	hsa-mir-26a	Root Resorption	This study aimed to identify the role of miR-26a in osteoclastogenesis and orthodontically induced inflammatory root resorption(OIIRR).
lncRNA target	34437815	hsa-mir-4677	Stomach Neoplasms	siCEMIP or PI3K/AKT signaling inhibitor (Akti-1/2 and LY294002) partly reversed the effects of miR
other	34437807	hsa-mir-200c	Bone Diseases	These results strongly indicate that bone grafts combining SEPS 3D-printed osteoconductive biomaterial-based scaffolds with osteoinductive miR-200c can be used as superior bone substitutes for the clinical treatment of large bone defects.
genetics_GWAS	34437653	hsa-mir-146a	Hepatitis B, Chronic	In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction.
genetics_GWAS	34437653	hsa-mir-155	Hepatitis B, Chronic	In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction.
lncRNA target	34436746	hsa-mir-1306	Iron Metabolism Disorders	These results suggested that H19 silencing alleviated OGD/R-triggered I/R injury at least partially depending on the regulation of the miR5p/BCL2L13 axis.
genetics_knock down_promote	34435652	hsa-mir-26a	Squamous Cell Carcinoma of Head and Neck	Collectively, the present study demonstrated that NORAD knockdown attenuated the migration, invasion and EMT of HNSCC stem cells via miR26a5p.
genetics_overexpression_promote	34435649	hsa-mir-101a	Atrial Fibrillation	Immunohistochemistry for collagen  and collagen III revealed a reduction in atrial collagen synthesis following miR101a3p overexpression in AF model rats.
circulation_biomarker_diagnosis_down	34435593	hsa-mir-342	Myocardial Infarction, Acute	3p in plasma exosomes might be responsible for their impaired cardioprotective potential.
lncRNA target	34435542	hsa-mir-370	Glioblastoma	CONCLUSION: Silencing of LINC01410 inhibits cell viability yet enhances apoptosis and sensitivity to TMZ in GBM cells by inactivating PTEN/AKT pathway via targeting miR
genetics_knock down_promote	34435526	hsa-mir-93	Carcinoma, Hepatocellular	5p knockdown repressed the progression of HCC via increasing ERBB4 and TETs-dependent DNA demethylation.
circulation_biomarker_diagnosis_up	34435525	hsa-mir-146b	Lesch-Nyhan Syndrome	This study revealed that miR-146b-5p level was declined and IFI35 abundance was elevated in serum of LN patients and LPS-challenged HK-2 cells.
genetics_overexpression_promote	34435522	hsa-mir-196b	Neoplasms, Multiple Primary	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies.
genetics_overexpression_promote	34435522	hsa-mir-196b	Abnormalities, Multiple	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies.
genetics_overexpression_promote	34435522	hsa-mir-196a	Abnormalities, Multiple	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies.
genetics_overexpression_promote	34435522	hsa-mir-196a	Neoplasms, Multiple Primary	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies.
genetics_overexpression_promote	34435522	hsa-mir-196	Neoplasms, Multiple Primary	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies.
genetics_overexpression_promote	34435522	hsa-mir-196	Abnormalities, Multiple	The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies.
lncRNA target	34435328	hsa-mir-143	Ischemic Stroke	Our results demonstrated for the first time that circ_0025984 protects astrocytes from ischemia-induced autophagy and apoptosis by targeting the miR
lncRNA target	34435325	hsa-mir-466	Stomach Neoplasms	The present study provides novel evidence for the clinical and biological significance of miR-466 expression as a possible biomarker for the prognosis and identifying patients with peritoneal metastasis, as well as a potential therapeutic target in patients with gastric cancer.
lncRNA target	34435195	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	3p suppresses NSCLC development by inhibiting CEP55 expression.
transcription factor target	34435140	hsa-mir-4521	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The results of this study showed that the low expression of miR-4521 indicated the poor prognosis of NSCLC and promoted cell proliferation, migration, and invasion by targeting FOXM1.
lncRNA target	34435045	hsa-mir-129	Myocardial Reperfusion Injury	miR-129 is an important biomarker for MIRI, as well as a potential therapy target.
other	34434963	hsa-mir-30	Osteoporosis	Additional experiments showed that Tnc regulated Wnt/beta-catenin signaling, and rescue experiment showed that miR5p could restore beta-catenin expression; additionally, animal experiments indicated that Wnt signaling was inactivated in the ovariectomized rats.
circulation_biomarker_diagnosis_ns	34434498	hsa-mir-16	Liver Cirrhosis	5p showed strong association with liver cancer in plasma.
circulation_biomarker_diagnosis_ns	34434498	hsa-let-7a	Liver Neoplasms	3p - in plasma and saliva of patients with HCV-related liver cirrhosis (n = 24), primary liver cancer (n = 24) and healthy volunteers (n = 21).
circulation_biomarker_diagnosis_ns	34434498	hsa-mir-21	Liver Neoplasms	5p showed strong association with liver cancer in plasma.
circulation_biomarker_diagnosis_ns	34434498	hsa-let-7a	Liver Cirrhosis	3p - in plasma and saliva of patients with HCV-related liver cirrhosis (n = 24), primary liver cancer (n = 24) and healthy volunteers (n = 21).
circulation_biomarker_diagnosis_ns	34434498	hsa-mir-16	Liver Neoplasms	5p showed strong association with liver cancer in plasma.
circulation_biomarker_diagnosis_ns	34434498	hsa-mir-21	Liver Cirrhosis	5p showed strong association with liver cancer in plasma.
circulation_biomarker_diagnosis_up	34434493	hsa-mir-21	Pancreatic Carcinoma	The combination of miRNAs-21, -210 tissue expression and serum CA19-9 showed 100% accuracy in the diagnosis of PA, as well as miR-181c expression in the plasma (PApxPCp).
lncRNA target	34434273	hsa-mir-139	Sepsis	5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR
lncRNA target	34434273	hsa-mir-139	Lung Injury	5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR
other	34434263	hsa-mir-150	Sepsis	Although microRNA-150 (miR-150) has been previously reported to be involved in the modulation of sepsis, the underlying molecular mechanism in sepsis remains poorly understood. In the present study, the human monocytic cell line THP-1 was treated with LPS to mimic sepsis in vitro, following which miR-150 and STAT1 expression were measured using reverse transcription-quantitative PCR or western blotting.
target gene	34434261	hsa-mir-483	Triple Negative Breast Neoplasms	Inhibition of miR-483-5p improves the proliferation, invasion and inflammatory response of triple-negative breast cancer cells by targeting SOCS3.
target gene	34434057	hsa-mir-130b	Breast Neoplasms	HOTAIR Facilitates Endocrine Resistance in Breast Cancer Through ESR1/miR-130b-3p Axis: Comprehensive Analysis of mRNA-miRNA-lncRNA Network.
other	34433636	hsa-mir-379	Prostatic Neoplasms	We found that the miR-379 editing frequency was higher in prostate cancer samples compared to benign prostatic hyperplasia samples.
other	34433636	hsa-mir-379	Prostatic Hyperplasia	We found that the miR-379 editing frequency was higher in prostate cancer samples compared to benign prostatic hyperplasia samples.
transcription factor target	34433394	hsa-mir-1297	Rhabdomyosarcoma 1	Besides, we constructed miRNA-mRNA network between DEMs target genes and DEGs in RM, including hsa-miR KLHL24 and hsa-miR-548a-5p-KLHL24 pairs.
genetics_overexpression_promote	34433333	hsa-mir-137	Arthritis, Rheumatoid	Next, experiments involving miR-137 overexpression were performed to analyze the role of miR-137 in human fibroblast-like synoviocytes-RA (HFLS-RA) using cell counting kit-8 (CCK-8) assay, EdU staining, Transwell assay and flow cytometry, respectively.
lncRNA target	34433131	hsa-mir-146b	Breast Neoplasms	Fluorescence in situ hybridization, double luciferase reporter gene analysis, RNA pull-down and RNA immunoprecipitation experiments were performed to explore the correlation of circ_RPPH1 with miR-146b-3p/E2F2 in BC. CONCLUSION: Circ_RPPH1/miR-146b-3p/E2F2 axis can promote the progression of BC, and it might be a latent therapeutic target for clinical BC.
genetics_knock down_suppress	34432784	hsa-mir-204	Melanoma	5p, and an inhibitory effect of FOXC1 knockdown on melanoma cell proliferation were revealed.
transcription factor target	34432732	hsa-mir-19	Pelvic Organ Prolapse	3p may affect the synthesis of Col-1 by targeting IGF-1 and that it may play an vital role in POP.
lncRNA target	34431595	hsa-mir-155	Sepsis	5p/WWC1 axis modulated sepsis-induced AKI progression, providing promising insight into therapeutic targets for sepsis-induced AKI.
lncRNA target	34431595	hsa-mir-155	Acute Kidney Injury	5p/WWC1 axis modulated sepsis-induced AKI progression, providing promising insight into therapeutic targets for sepsis-induced AKI.
genetics_overexpression_promote	34431454	hsa-mir-199a	Hyperuricemic Nephropathy	Collectively, overexpression of miR-199a aggravated the renal injury in HN rats.
lncRNA target	34431444	hsa-mir-92a	Prostatic Neoplasms	MiR-92a might play a key role in regulating the proliferation, migration and invasion of PCa cells through the PTEN/Akt signaling pathway.
circRNA target	34431434	hsa-mir-132	Arthritis, Rheumatoid	In conclusion, the protective effect of Circ-Sirt1 on MH7A depends on inhibiting cell proliferation, promoting apoptosis and miRmediated Sirt1 pathway to reduce inflammation.
lncRNA target	34431433	hsa-mir-185	Osteoporosis-pseudoglioma syndrome	CONCLUSION: Our study elaborated that PART1/miR5p/RUNX3 feedback contributed to osteogenic differentiation and inhibited the hBMSCs apoptosis, suggesting that PART1 might be a novel target for OP treatment.
lncRNA target	34431405	hsa-mir-1	Pyloric Hypomotility	pylori infection was associated with reduced miR-1, epithelial to mesenchymal transition, and pyloric hypomotility. Targeting miR-1 could be valuable in the clinical management of pyloric hypofunction.
other	34431214	hsa-mir-363	Graves Disease	5p may play an important role in Treg cell dysfunction and immune tolerance abnormalities in GD patients.
lncRNA target	34431162	hsa-mir-296	Carcinoma, Renal Cell	In conclusion, our study indicated that HSPB1P1 contributed to RCC progression by targeting the miR5p/HMGA1 axis, and should be considered as a promising biomarker and therapeutic target for clinical applications.
genetics_knock down_promote	34431160	hsa-mir-98	Osteoporosis, Postmenopausal	In summary, M1Mphi-derived exosomal miR-98 exacerbates bone loss and OP by downregulating DUSP1 and activating the JNK signaling pathway. miR-98 may therefore serve as a therapeutic target in OP management.
lncRNA target	34431063	hsa-mir-127	Carcinoma, Hepatocellular	To conclude, this research reported that MSC-derived Exo block malignant behaviors of HCC-sourced CSCs through a C5orf66-AS1/miR3p/DUSP1/ERK axis.
lncRNA target	34431044	hsa-mir-1273g	Prostatic Neoplasms	In total, miR-1273 g-3p was increased in PCa and identified as a therapeutic target and a prognostic factor for PCa patients.
target gene	34430707	hsa-mir-130a	Parkinson Disease	HAGLR promotes neuron differentiation through the miR-130a-3p-MeCP2 axis.
lncRNA target	34430706	hsa-mir-128	Sepsis	3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR
lncRNA target	34430706	hsa-mir-128	Acute Lung Injury	3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR
other	34430597	hsa-mir-4433b	Polycystic Ovary Syndrome	3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p.
other	34430597	hsa-mir-135b	Polycystic Ovary Syndrome	3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p.
other	34430597	hsa-mir-1231	Polycystic Ovary Syndrome	3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p.
other	34430597	hsa-mir-4649	Polycystic Ovary Syndrome	3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p.
other	34430597	hsa-mir-609	Polycystic Ovary Syndrome	3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p.
lncRNA target	34430434	hsa-mir-424	Hemangioma, Cavernous	We aimed to explore the effect of propranolol on the expression of microRNA (miR)-424 in IHA tissues and XPTS-1 cells, as well as its molecular mechanism of inhibiting XPTS-1 cell activity.
other	34430428	hsa-mir-7	Azoospermia	AKT3-related miRNAs, including hsa-miR5p and hsa-miR-519d-3p, might be responsible for cryptorchidism and cryptorchidism-induced azoospermia and serve as potential biomarkers.
other	34430428	hsa-mir-519d	Azoospermia	AKT3-related miRNAs, including hsa-miR5p and hsa-miR-519d-3p, might be responsible for cryptorchidism and cryptorchidism-induced azoospermia and serve as potential biomarkers.
genetics_overexpression_promote	34429769	hsa-mir-27b	Carcinoma, Squamous Cell, Cutaneous	Moreover, the inhibitory effect of miR-27b-3p on the migratory and invasive abilities of CSCC cells was abolished by MMP-13 overexpression.
circulation_biomarker_diagnosis_up	34429765	hsa-mir-130b	Stomach Neoplasms	All these results suggested that circulating miR-130b and blood routine parameters might be potential biomarkers, and combinations of measurements of these biomarkers may improve the GC, EGC and Pre diagnostic accuracy.
other	34429762	hsa-mir-15a	Carcinoma, Non-Small-Cell Lung	Circular RNA SLC26A4 regulates the maturation of microRNA-15a in non-small cell lung cancer cells.
target gene	34429758	hsa-mir-19a	Ovarian Neoplasms	GATA6-AS1 inhibits ovarian cancer cell proliferation and migratory and invasive abilities by sponging miR-19a-5p and upregulating TET2.
lncRNA target	34429400	hsa-mir-338	Esophageal Squamous Cell Carcinoma	3p was found to directly target SRY-box transcription factor 4 (SOX4) in ESCC cells.
transcription factor target	34429120	hsa-mir-499a	Prostatic Neoplasms	At the same time, we found that miR-499a combined with UBE2V2 inhibited the expression of UBE2V2 in prostate cancer cells. CONCLUSIONS: In conclusion, our results indicate that miR-499a inhibits the proliferation of human prostate cancer cells by targeting UBE2V2, which will provide a potential target for the treatment of prostate cancer.
lncRNA target	34429073	hsa-mir-29	Acute Kidney Injury	CONCLUSIONS: LncRNA TUG can promote PTEN expression by competitively binding to miR-29 to promote autophagy and inhibited apoptosis, thus aggravating acute renal injury in I/R-treated rats.
circulation_biomarker_diagnosis_ns	34428771	hsa-mir-24	Metabolic Diseases	Therefore, it is particularly important to study the abnormal regulation of circulating miR
circulation_biomarker_diagnosis_ns	34428771	hsa-mir-24	Obesity	Therefore, it is particularly important to study the abnormal regulation of circulating miR
genetics_overexpression_promote	34428620	hsa-mir-182	Kidney Failure, Chronic	Further research found that overexpressed FOXO3a partially reversed the inhibitory effect of miR-182 on CRF rats.
transcription factor target	34428587	hsa-mir-143	Cardiomyopathies	CONCLUSION: METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR(miR-143)-Yap/Ctnnd1 axis.
other	34428251	hsa-mir-1202	Cardiomyopathies	However, the role of miRNA-1202 and its mechanism in myocardial fibrosis remain unclear.
transcription factor target	34428251	hsa-mir-1202	Fibrosis	However, the role of miRNA-1202 and its mechanism in myocardial fibrosis remain unclear. MiR-1202 targets nNOS for negative regulation of HCFs fibrosis by decreasing cell differentiation, collagen deposition and the activity of the TGF-beta1/Smad2/3 pathway.
other	34428251	hsa-mir-1202	Atrial Fibrillation	Recently, miRNA-1202 have been reported to be up-regulated in AF.
genetics_overexpression_promote	34427978	hsa-mir-513a	Breast Neoplasms	Feedback approaches validated that miR-513a-5p overexpression or KLF6 depletion reversed the inhibitory effects of ZBED3-AS1 upregulation on viability, proliferative capacity, migration, and invasion of BC cells.
other	34427967	hsa-mir-195	Stomach Neoplasms	At the post-transcriptional level, LINC00511 sponged miR5p to elevate SOX4 expression in GC cells.
genetics_overexpression_promote	34427876	hsa-mir-142	late onset Parkinson's disease	LINC00943 (or KPNA4) overexpression or miR
genetics_overexpression_promote	34427871	hsa-mir-1274a	Carcinoma, Non-Small-Cell Lung	Functional studies in two NSCLC cell lines have shown that overexpression of miR-1274a could promote cell proliferation, migration, and invasion.
transcription factor target	34427853	hsa-mir-214	psoriasis 1	3p/FOXM1 axis in keratinocytes could be a novel target in the treatment of psoriasis.
other	34427668	hsa-mir-144	Uterine Diseases	Implantation of an intrauterine device containing copper implantation can up-regulate the expression of miR3p in endometrial tissue, and therefore, decreases the mRNA and protein expression levels of genes related to endometrial injury and tissue repair, including the MT/NF-kappaB/MMP damage pathway and the THBS-1/TGF-beta/SMAD3 repair pathway.
lncRNA target	34426596	hsa-mir-708	Neoplasms, Second Primary	We demonstrate here that miR-708 (i) is the first miRNA shown to be differentially regulated in TEP and ALT cancer cells, (ii) possesses tumor suppressor function, and (iii) deregulates CARF and p21(WAF1)-mediated signaling to limit proliferation in TEP cells.
genetics_overexpression_promote	34426596	hsa-mir-708	Chemical and Drug Induced Liver Injury	Its overexpression induced suppression of cell migration, invasion, and angiogenesis in both TEP and ALT cells, although cell proliferation was inhibited only in TEP cells suggesting that ALT cells may have acquired the ability to escape inhibition of cell proliferation by sustained miR-708 overexpression.
genetics_overexpression_promote	34426596	hsa-mir-708	Polydactyly	Its overexpression induced suppression of cell migration, invasion, and angiogenesis in both TEP and ALT cells, although cell proliferation was inhibited only in TEP cells suggesting that ALT cells may have acquired the ability to escape inhibition of cell proliferation by sustained miR-708 overexpression.
genetics_overexpression_promote	34426559	hsa-mir-33a	Esophageal Squamous Cell Carcinoma	The repression of miR-33a-5p by inhibitor or DKK1 overexpression presented the conversed effects on EC cells.
lncRNA target	34426436	hsa-mir-126	Lymphoma, T-Cell, Peripheral	5p expression regulate RhoA-GTPase and inhibit T-cell migration, crucial for AITL pathobiology.
lncRNA target	34426436	hsa-mir-145	Lymphoma, T-Cell, Peripheral	5p expression regulate RhoA-GTPase and inhibit T-cell migration, crucial for AITL pathobiology.
other	34426107	hsa-mir-26b	Arthritis	Finally, we concluded that the combination therapy modulated miR-26b and miR-20a as well as GSK-3beta/NF-kappaB/NLRP-3 pathway, provided additive anti-inflammatory and anti-oxidant effects and offered an additional hepatoprotective effect as compared to untreated arthritic rats and MTX-treated groups, suggesting its promising role to be used as replacement therapy to MTX in RA.
other	34426107	hsa-mir-20a	Arthritis	Finally, we concluded that the combination therapy modulated miR-26b and miR-20a as well as GSK-3beta/NF-kappaB/NLRP-3 pathway, provided additive anti-inflammatory and anti-oxidant effects and offered an additional hepatoprotective effect as compared to untreated arthritic rats and MTX-treated groups, suggesting its promising role to be used as replacement therapy to MTX in RA.
lncRNA target	34425536	hsa-mir-503	Reperfusion Injury, Renal Ischemia	Given the well established involvement of Wnt/beta-catenin pathway in fibrosis, this study suggested that dysregulations of Wnts and miR5p coordinate in mediating cadmium-induced kidney fibrosis.
genetics_overexpression_promote	34425282	hsa-mir-142	Retinoblastoma	5p-mediated effects on retinoblastoma progression were blocked by MYCN overexpression in retinoblastoma cells.
lncRNA target	34425198	hsa-mir-204	Zika Virus Infection	In our current follow-up study, we investigate that WNT2 is downregulated in response to ZIKV E protein in human fetal NSCs and WNT2 is the molecular target of microRNA miR
other	34425168	hsa-mir-222	Pulmonary Fibrosis	Our findings indicate that EMT in alveolar epithelial cells may occur before pulmonary fibrosis, and miR-222 may be used as a potential marker for early prediction of pulmonary fibrosis.
transcription factor target	34424910	hsa-mir-10a	Melanoma	RESULTS: We discovered that miR-10a-5p expression was lower in melanoma cells and high expression of miR-10a-5p suppressed the proliferation, migration and invasion abilities of melanoma cells.
lncRNA target	34424826	hsa-mir-337	Osteosarcoma	3p and mediates the ceRNA network to promote the expression of ZNF652, thus suppresses osteosarcoma proliferation, migration and invasion.
target gene	34424812	hsa-mir-663a	Glioma	Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway.
other	34424807	hsa-mir-363	Breast Neoplasms	Taken together, the present study suggested that FOXD3-AS1 sponges miR-363 to upregulate TFF1 expression, leading to PI3K/Akt signaling activation and anti-estrogen resistance in BC cells.
epigenetics	34424481	hsa-mir-152	Cardiomyopathies	Our results stand out together DNMT1 methylation regulates miR3p to slow the progression of cardiac fibrosis by inhibiting the Wnt1/beta-catenin pathway.
lncRNA target	34424120	hsa-mir-620	Osteosarcoma	Apatinib-enhanced LINC00261 restrained OS via miR-620/PTEN axis, indicating LINC00261 might promote the efficacy of Apatinib on OS.
exosome	34423867	hsa-mir-23a	Pain, Inflammatory	Bioinformatics was initially performed to predict the inflammatory pain related downstream targets of miR-23a-3p in macrophage-derived extracellular vesicles (EVs).
genetics_knock down_suppress	34423784	hsa-mir-433	Glioma	These evidences manifested that knockdown of circ_0008344 exerted the radiosensitivity-promoting effect on glioma via the miR
other	34423778	hsa-mir-146b	Inflammation	Identification of Mir146b as a potential regulator of macrophage aging provides novel insights into immune dysfunction associated with aging.
other	34423778	hsa-mir-146b	Immune System Diseases	Identification of Mir146b as a potential regulator of macrophage aging provides novel insights into immune dysfunction associated with aging.
genetics_overexpression_suppress	34423728	hsa-mir-134	Ovarian Neoplasms	TRIM44 overexpression could counteract the inhibitory effects of miR
other	34423698	hsa-mir-523	Arthritis, Rheumatoid	CONCLUSION: ZNF667-AS1 exerts protective effects during RA development by sponging miR3p and inactivating the JAK/STAT signalling.
genetics_knock down_promote	34423389	hsa-mir-671	Arthritis, Rheumatoid	5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression.
lncRNA target	34423048	hsa-mir-587	Carcinoma, Hepatocellular	lncRNA PANTR1 promotes HCC progression via mediating the miR
transcription factor target	34423038	hsa-mir-210	Breast Neoplasms	The expression of miR-210 has a correlation with chemoresistance of breast cancer MCF-7 cells. MiR-210 regulates the JAK-STAT signal transduction pathway by targeting PIAS4, thus exerting an effect on breast cancer chemosensitivity.
exosome	34422980	hsa-mir-204	Pulmonary Fibrosis	5p antagomir were injected into rats to investigate the effect of exosomal miR
other	34422944	hsa-mir-19a	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
other	34422944	hsa-mir-205	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
other	34422944	hsa-mir-143	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
other	34422944	hsa-mir-19b	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
other	34422944	hsa-mir-20a	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
other	34422944	hsa-mir-24	Mastitis	It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis.
genetics_overexpression_suppress	34422922	hsa-mir-200a	Myocardial Infarction	Subsequent assays, including echocardiography, enzyme-linked immunosorbent assays (ELISAs), hematoxylin-eosin (H&E) staining, hematoxylin-basic fuchsin-picric acid (HBFP) staining, TdT-mediated dUTP nick-end labeling (TUNEL) staining, immunofluorescence staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting revealed that miR-200a-3p overexpression inhibited cardiomyocyte pyroptosis and alleviated CME-induced myocardial injury by inhibiting the TXNIP/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathway.
circulation_biomarker_diagnosis_up	34422901	hsa-mir-128	Diabetic Retinopathy	Conclusion: CircFTO promotes angiogenesis and impairs the blood-retinal barrier in vitro and in vivo by binding with miR3p to upregulate TXNIP in DR.
circulation_biomarker_diagnosis_ns	34422806	hsa-mir-484	Carcinoma, Hepatocellular	TMEM220-AS1, which was detected primarily in the cytoplasm, functioned as an miRNA sponge to bind miR-484 and promote the level of membrane-associated guanylate kinase, WW, and PDZ domain containing 1 (MAGI1), thereby curbing the malignant phenotypes of HCC cells. In conclusion, low levels of TMEM220-AS1 promote proliferation and metastasis through the miR-484/MAGI1 axis in HCC.
genetics_knock down_promote	34422671	hsa-mir-381	Colorectal Neoplasms	3p suppression reversed the inhibitory actions of LINC01569 knockdown on the expression of RAP2A and CRC progression.
lncRNA target	34422645	hsa-mir-143	Glioma	miR-143 inhibition increased HIF1A protein levels, promoted glioma cell invasion and DNA synthesis. Altogether a regulatory axis consisting of OR7E156P, miR-143, and HIF1A, was identified which is deregulated in glioma, and the process of the OR7E156P/miR-143/HIF1A axis modulating glioma cell invasion through ZEB1 and HUVEC tube formation through VEGF was demonstrated.
circulation_biomarker_diagnosis_ns	34422636	hsa-mir-195	Stomach Neoplasms	Plasma exosomal miR-195-5p and miR-211-5p may become potential biomarkers for GC diagnosis, and may be useful in predicting tumor phenotype.
circulation_biomarker_diagnosis_ns	34422636	hsa-mir-211	Stomach Neoplasms	Plasma exosomal miR-195-5p and miR-211-5p may become potential biomarkers for GC diagnosis, and may be useful in predicting tumor phenotype.
genetics_knock down_promote	34422217	hsa-mir-12119	Multiple Myeloma	After knockdown of MSTRG.29039.1 in MM cell lines, the expression of OSMR was decreased, and the expression of hsa-miR-12119 was upregulated which can also promote cell apoptosis and inhibit proliferation. Then, we knocked down hsa-miR-12119 and MSTRG.29039.1, we found that apoptosis of MM cells was reduced, and cell proliferation was increased compared with just knocking down hsa-miR-12119.
genetics_GWAS	34422215	hsa-mir-23a	Acute Lung Injury	Additional findings demonstrated that the miR-23a-5p agomir exacerbated LPS-induced ALI via activating apoptosis signal-regulating kinase 1 (ASK1), and that pharmacological or genetic inhibition of ASK1 significantly repressed the deleterious effects of the miR-23a-5p agomir.
transcription factor target	34422048	hsa-mir-605	Colonic Neoplasms	It was found that KIF3B was a target of KIF3B; decreased KIF3B could reverse the effects of miR
genetics_knock down_suppress	34421997	hsa-mir-485	Osteosarcoma	Circ_0084582 knockdown decreased OS growth in vivo partly by the miR
circulation_biomarker_diagnosis_up	34421993	hsa-mir-29	Breast Neoplasms	Frequencies of MEG3 rs7158663 GA/AA genotype and A allele were significantly higher in BC patients compared to the controls results showed that serum MEG3 levels were significantly lower, according to the presence of the A allele in different study groups while the expression of miR-182 and miRNA 29 were significantly elevated. MEG3, miR-182, and miRNA-29 are key genes involved in the development of BC, are considered as a novel potential non-invasive diagnostic biomarker for BC.
circulation_biomarker_diagnosis_up	34421993	hsa-mir-182	Breast Neoplasms	Frequencies of MEG3 rs7158663 GA/AA genotype and A allele were significantly higher in BC patients compared to the controls results showed that serum MEG3 levels were significantly lower, according to the presence of the A allele in different study groups while the expression of miR-182 and miRNA 29 were significantly elevated. MEG3, miR-182, and miRNA-29 are key genes involved in the development of BC, are considered as a novel potential non-invasive diagnostic biomarker for BC.
lncRNA target	34421987	hsa-mir-124	Thyroid Carcinoma, Anaplastic	3p/ROR1 axis potentially acted as a potential target for the diagnosis of ATC.
genetics_overexpression_suppress	34421982	hsa-mir-125a	Colonic Neoplasms	Results: TNK2 was overexpressed in colon cancer cell lines, and it was found to directly bind to miR-125a-3p, which was downregulated in these cell lines.
transcription factor target	34421906	hsa-mir-130a	Liver Cirrhosis	In this study, we investigated the biological functions of miR-130a-3p on the liver fibrosis of schistosomiasis in vivo and in vitro. Our findings suggested that miR-130a-3p might represent as the potential candidate biomarker and therapeutic target for the prognosis identification and treatment of schistosomiasis liver fibrosis.
genetics_overexpression_promote	34421892	hsa-mir-223	Blood Group Incompatibility	overexpressing immature (im)DCs.
circRNA target	34421353	hsa-mir-125a	Breast Neoplasms	These findings indicate that circBCBM1 is involved in breast cancer brain metastasis via circBCBM1/miR-125a/BRD4 axis.
lncRNA target	34420942	hsa-mir-223	Diabetes Mellitus, Type 2	CONCLUSIONS: It can be concluded that long-term moderate-intensity aerobic training might be effective for reducing the occurrence of atherothrombotic events leading to premature death in T2DM patients through the modulation of miRNA-223, P2RY12 receptor expression, and platelet function.
transcription factor target	34420810	hsa-mir-197	Diabetic Retinopathy	3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways.
transcription factor target	34420810	hsa-mir-24	Diabetic Retinopathy	3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways.
transcription factor target	34420810	hsa-mir-184	Diabetic Retinopathy	3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways.
transcription factor target	34420141	hsa-mir-27a	Glioma	MiR-27a-5p was highly expressed in in patients with glioma, which was associated with poor prognosis, while shFOSL1-inhibited miR-27a-5p expression enhanced the sensitivity of glioma stem cells to radiotherapy. Silent FOSL1 strengthened the radiosensitivity of glioma by down-regulating miR-27a-5p.
other	34420031	hsa-mir-346	Colorectal Neoplasms	On the whole, SOX2-induced circ_0026628 sponged miR-346 and recruited FUS protein to augment SP1, triggering the downstream Wnt/beta-catenin pathway to facilitate CRC progression.
circRNA target	34419960	hsa-mir-136	Hepatitis B	Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR
circRNA target	34419960	hsa-mir-136	Carcinoma, Hepatocellular	Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR
target gene	34419497	hsa-mir-26a	Colorectal Neoplasms	miR-26a enhances colorectal cancer cell growth by targeting RREB1 deacetylation to activate AKT-mediated glycolysis.
other	34419445	hsa-mir-495	Retinoblastoma	Our study highlights the importance of bioinformatic analysis in identifying potential markers and mechanisms associated with the malignant transformation of RB, and provides evidence to suggest that PCDHB5 and the ceRNA regulatory network of MALAT1/miR3p/BUB1 are involved in the progression of RB.
circulation_biomarker_diagnosis_up	34419170	hsa-mir-335	Depression	Compared with the healthy controls, 2 miRNAs in the plasma exosomes of patients with TRD showed significant differences in expression, among which has-miR
circulation_biomarker_diagnosis_up	34419170	hsa-mir-1292	Depression	Compared with the healthy controls, 2 miRNAs in the plasma exosomes of patients with TRD showed significant differences in expression, among which has-miR
circRNA target	34419070	hsa-mir-1294	Carcinoma, Pancreatic Ductal	CONCLUSION: CircEYA3 promotes the progression of PDAC through the miR-1294/c-Myc signalling axis, and circEYA3 may be an efficient molecular therapeutic target in PDAC.
lncRNA target	34419065	hsa-mir-26b	Breast Neoplasms	In summary, METTL3 promoted tumorigenesis of BC via the MALAT1/miR-26b/HMGA2 axis.
genetics_knock down_suppress	34419049	hsa-mir-152	Carcinoma, Endometrioid	Loss/gain-of-function experiments certified the impacts of OIP5-AS1 and miR
other	34418898	hsa-mir-155	Multiple Sclerosis	The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet.
other	34418898	hsa-mir-23b	Multiple Sclerosis	The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet.
other	34418898	hsa-mir-326	Multiple Sclerosis	The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet.
circulation_biomarker_diagnosis_ns	34418889	hsa-mir-206	Mouth Neoplasms	Serum miR-206 might be an effective indicator for early detection of oral cancer.
circRNA target	34418850	hsa-mir-29b	Cardiomegaly	Consequently, the data demonstrated that circRNA_0001859 promoted the process of cardiac hypertrophy through suppressing miR-29b-3p leading to enhance Ctnnb1 level, and activated downstream pathway molecules LEF1/IGF-2R.
other	34418770	hsa-mir-18a	Glioblastoma	This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy.
other	34418770	hsa-mir-92a	Glioblastoma	This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy.
other	34418770	hsa-mir-15b	Glioblastoma	This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy.
other	34418770	hsa-mir-200b	Glioblastoma	This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy.
other	34418770	hsa-mir-23a	Glioblastoma	This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy.
other	34418506	hsa-mir-10a	Depressive Disorder, Major	In conclusion, these results indicate the involvement of miR-374b and miR-10a in the biological mechanisms and therapeutic response of MDD, and provide new insights for exploring miRNAs as potential biomarkers for MDD.
other	34418506	hsa-mir-374b	Depressive Disorder, Major	In conclusion, these results indicate the involvement of miR-374b and miR-10a in the biological mechanisms and therapeutic response of MDD, and provide new insights for exploring miRNAs as potential biomarkers for MDD.
other	34418493	hsa-mir-559	Abortion, Habitual	Results showed differential expression of miRNAs implyingmiR-16 and miR-559 as potential biomarkers of RSA in infected women.
other	34418493	hsa-mir-16	Abortion, Habitual	Results showed differential expression of miRNAs implyingmiR-16 and miR-559 as potential biomarkers of RSA in infected women.
other	34418490	hsa-mir-497	Arthritis, Rheumatoid	Our preliminary results showed that the CDKN2B-AS1/MIR497/TXNIP axis might regulate macrophages of rheumatoid arthritis patients. Compared to cells from healthy donors, cells from rheumatoid arthritis patients expressed higher levels of CD40 and CD80 and lower levels of CD16, CD163, CD206, and CD200R after polarization, they also expressed higher CDKN2B-AS1, lower MIR497, and higher TXNIP.
transcription factor target	34418417	hsa-mir-375	Carcinoma, Brown-Pearce	The miR-375 expression decreased the luciferase activity dose-dependently when co-transfected with the AjBAG2 3'-UTR-luciferase reporter containing the miR-375 target site in epithelioma papulosum cyprini (EPC) cells.
transcription factor target	34418417	hsa-mir-375	Pneumonia, Mycoplasma	The miR-375 expression decreased the luciferase activity dose-dependently when co-transfected with the AjBAG2 3'-UTR-luciferase reporter containing the miR-375 target site in epithelioma papulosum cyprini (EPC) cells.
other	34417924	hsa-mir-140	Stomach Neoplasms	LncRNA CCAT1 Upregulates ATG5 to Enhance Autophagy and Promote Gastric Cancer Development by Absorbing miR-140-3p.
other	34417456	hsa-mir-205	Prostatic Neoplasms	SQLE expression is controlled by micro-RNA 205 (miR-205), which is significantly downregulated in advanced PCa.
other	34417328	hsa-mir-263b	Sensation Disorders	"Fifth, miR-263b null mutants show reduced ""touch-response"" behavior and a compromised response to sound, both characteristic of larval sensory deficits."
lncRNA target	34416910	hsa-mir-600	Carcinoma, Pancreatic Ductal	targeted gene NACC1, which facilitates the autophagy response of PDAC cells for adaptation of proliferation via Akt/mTOR pathway.
circulation_biomarker_diagnosis_ns	34416903	hsa-mir-92a	Diabetes, Gestational	We identified a set of proteins in skeletal muscle biopsies from women with GDM associated with JAK-STAT signaling which could be targeted by the miRNA-92a-3p within circulating EVs. We suggest that miRNA-92a-3p within EVs might be a protected mechanism to increase skeletal muscle insulin sensitivity in GDM.
target gene	34416900	hsa-let-7	Ovarian Neoplasms	Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis.
genetics_overexpression_promote	34416888	hsa-mir-638	Breast Neoplasms	Functionally, the viability, migration, and invasion of the breast cancer cells were suppressed by miR-638 overexpression.
lncRNA target	34416339	hsa-mir-582	Colorectal Neoplasms	5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management.
transcription factor target	34416282	hsa-mir-5189	Venous Thrombosis	3p could inhibit apoptosis and promote thrombus organization in DVT possibly via Notch signaling pathway.
other	34415727	hsa-mir-29b-1	Alzheimer Disease	The purpose of this study was to investigate whether miR-29a/b1 affected the expression of beta-secrete enzymes (BACE1) in the process of amyloid beta-protein (Abeta) deposition caused by aluminum exposure. In aluminum-exposed groups, the expression of miR-29a and miR-29b1 decreased, while the expression of amyloid protein Abeta1-42 and BACE1 increased.
other	34415727	hsa-mir-29a	Alzheimer Disease	The purpose of this study was to investigate whether miR-29a/b1 affected the expression of beta-secrete enzymes (BACE1) in the process of amyloid beta-protein (Abeta) deposition caused by aluminum exposure. In aluminum-exposed groups, the expression of miR-29a and miR-29b1 decreased, while the expression of amyloid protein Abeta1-42 and BACE1 increased.
genetics_overexpression_suppress	34415232	hsa-mir-624	Esophageal Squamous Cell Carcinoma	The chemotherapy-sensitive cell line KYSE150 and chemotherapy-resistant cell line KYSE410 were transfected with an overexpression plasmid or shRNA to study the effect of miR-624/ARRDC3/YAP/HIF1alpha axis on ESCC cell resistance to CIS and PT.
transcription factor target	34415065	hsa-mir-599	Breast Neoplasms	Hsa-miR-599 combined with BRD4 inhibited breast cancer progression through targeting Jagged1/Notch1 pathway.
lncRNA target	34414857	hsa-mir-421	Neurotoxicity Syndromes	Moreover, it was identified that miR-421 was a target of ZFAS1, and ZFAS1 regulated the bupivacaine-induced neurotoxicity via miR-421. In conclusion, our results demonstrated that ZFAS1 alleviated bupivacaine-induced neurotoxicity through the miR-421/ZNF564 axis, suggesting a new strategy for the amelioration of bupivacaine-induced neurotoxicity.
genetics_knock down_suppress	34414852	hsa-mir-29	Cicatrix, Hypertrophic	In conclusion, NEAT1 knockdown protected against hypertrophic scarring by modulating the miR3p/FRS2 axis, which is a viable target in scar treatment.
genetics_overexpression_promote	34414664	hsa-mir-1	Carcinoma, Ovarian Epithelial	Overexpression of GAS5 or inhibition of miR
lncRNA target	34414458	hsa-mir-6884	Ovarian Neoplasms	Notably, silencing of RHPN1AS1 functionally reversed the oncogenic effect induced by the miR68845p inhibitor, while the miR68845p inhibitor markedly restored the inhibition of ovarian carcinogenesis modulated by silencing TOP2A in ovarian cancer.
lncRNA target	34414457	hsa-mir-15a	Colonic Neoplasms	The present study demonstrated that hsamiR15a5p alleviated the proliferation, migration and invasion of colon cancer by targeting the CCND1 gene, which represents a potential molecular target for the diagnosis and treatment of colon cancer.
lncRNA target	34414456	hsa-mir-17	Endometrial Hyperplasia	In conclusion, the present study demonstrated that miR175p inhibited the phenotypic modulation VSMCs stimulated by PDGFBB by downregulating HOXB13, indicating that these factors may be potential therapeutic targets for intimal hyperplasia.
lncRNA target	34414454	hsa-mir-28	COVID-19	The findings of the present study suggested that miR283p inhibits ADAM17dependent ACE2 ectodomain shedding in 293T cells treated with the Sprotein of SARSCoV2, which suggested the potential therapeutic role of miR283p mimic in the prevention and treatment of patients with SARSCoV2.
lncRNA target	34414449	hsa-mir-1276	Breast Neoplasms	Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR1276/SIRT4 axis.
circRNA target	34414414	hsa-mir-485	Thyroid Cancer, Papillary	CONCLUSION: Our results discovered the functional network of hsa_circ_0023990 in dedifferentiated TC development by facilitating cell proliferation and glycolysis via miR5p/FOXM1 axis, implying that hsa_circ_0023990 might be a potential therapeutic target for the dedifferentiated TC treatment.
lncRNA target	34414282	hsa-mir-219	Spinal Cord Injuries	In conclusion, XIST silencing promoted microglial cell viability and repressed apoptosis and inflammation by sponging miR
lncRNA target	34414175	hsa-mir-675	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	The newly identified LNC000093 served as a competitive endogenous RNA for miR5p and reversed the imatinib resistance in CML cells through regulating RUNX1 expression.
lncRNA target	34414106	hsa-mir-185	Colonic Neoplasms	Results showed that inhibiting miR-185 expression in the COAD cell line significantly restored the expression of ARID1A.
other	34413954	hsa-mir-21	Metabolic Diseases	We demonstrate the approach on the pre-miR-21 stem-loop, which is of significant interest in oncology and metabolic diseases.
exosome	34413928	hsa-mir-25	Lymphoma, T-Cell, Peripheral	PTL seems to be related to the decreased exosomal miR
circRNA target	34413915	hsa-mir-338	Carcinoma, Non-Small-Cell Lung	3p inhibitors reversed the suppressor ability of circ_0005909 silence on NSCLC behaviors.
genetics_overexpression_promote	34413821	hsa-mir-26a	Intervertebral Disc Degeneration	Overexpression of miR-26a-5p promoted ECM synthesis in degenerative NPCs. In conclusion, lncRNA GAS5 sponged miR-26a-5p to upregulate PTEN and inhibit the PI3K/Akt pathway, thus inhibiting ECM synthesis of degenerative NPCs.
circulation_biomarker_diagnosis_down	34413820	hsa-mir-124	Basal Ganglia Hemorrhage	3p was downregulated in the serum of basal ganglia ICH patients and LPS-induced microglia, and miR
other	34413720	hsa-mir-130a	Osteochondritis Dissecans	Last but not least, we also demonstrated that reducing miR-130a-3p expression partially rescued neuronal morphological changes after OGD in vitro.
lncRNA target	34413652	hsa-mir-1826	Prostatic Neoplasms	CONCLUSION: In summary, the low expression of miR-1826 may promote the progression of PC, and the low expression of miR-1826 is also associated with a poor prognosis in PC patients.
genetics_overexpression_suppress	34413269	hsa-mir-224	Osteoarthritis	Following prediction analysis of circRNA and miRNA targets, dual-luciferase reporter and silencing/overexpression assays suggested that a regulatory network composed of hsa_circ_0134111, miR
target gene	34413167	hsa-mir-24	Carcinoma, Hepatocellular	Additionally, miR3p was proven to be an upstream suppressor of CBS in HCC.
lncRNA target	34412616	hsa-mir-214	Colorectal Neoplasms	Finally, PD-L1 was confirmed as important target for miR-214 in CRC. CONCLUSION: In conclusion, our study reveals that a novel axis circEIF3K/miR-214/PD-L1 mediates hypoxia-induced CRC progression via CAF, providing the rationale for developing new targeted therapeutics to treat CRC.
lncRNA target	34411602	hsa-mir-129	Eye Infections, Fungal	5p is a novel small molecule that regulates autophagy by targeting Atg14, indicating that it may be a proinflammatory and therapeutic target for fungal keratitis.
other	34411594	hsa-mir-21	Ovarian Diseases	Polycystic ovary syndrome (PCOS) patients have increased miR-21 levels in their sera, granulosa cells, and follicular fluid, and this mi-RNA plays a role in the pathophysiology and follicular dysfunction of PCOS patients.
other	34411594	hsa-mir-21	Polycystic Ovary Syndrome	Polycystic ovary syndrome (PCOS) patients have increased miR-21 levels in their sera, granulosa cells, and follicular fluid, and this mi-RNA plays a role in the pathophysiology and follicular dysfunction of PCOS patients.
other	34410972	hsa-mir-92b	Colorectal Neoplasms	CONCLUSION: We have successfully confirmed miR-92b-3p to be up-regulated in tumor tissue of mCRC patients with good response to bevacizumab/FOLFOX therapy.
lncRNA target	34410682	hsa-mir-17	Sepsis	CONCLUSION: CircTLK1 sponged miR5p to aggravate mtDNA oxidative damage, mitochondrial dysfunction and cardiomyocyte apoptosis via activating PARP1/HMGB1 axis during sepsis, indicating that circTLK1 may be a putative therapeutic target for septic cardiomyopathy.
exosome	34410623	hsa-mir-627	Non-alcoholic Fatty Liver Disease	In conclusion, these data demonstrate that HUC-MSCs-derived exosomal miR
circulation_biomarker_diagnosis_ns	34410579	hsa-mir-223	Atherosclerosis	CONCLUSIONS: Taken together, these data suggest that plasma levels of miR
circulation_biomarker_diagnosis_ns	34410579	hsa-mir-223	Carotid Stenosis	CONCLUSIONS: Taken together, these data suggest that plasma levels of miR
other	34410499	hsa-mir-5196	Stroke	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
other	34410499	hsa-mir-6780b	Stroke	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
other	34410499	hsa-mir-942	Cardiovascular Diseases	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
other	34410499	hsa-mir-942	Stroke	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
other	34410499	hsa-mir-5196	Cardiovascular Diseases	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
other	34410499	hsa-mir-6780b	Cardiovascular Diseases	5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection.
lncRNA target	34410163	hsa-mir-142	Colorectal Neoplasms	3p/X-linked inhibitor of apoptosis axis.
lncRNA target	34409981	hsa-mir-1271	Alzheimer Disease	Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consistent functional down-regulation in post-mortem AD and T2D tissues.
lncRNA target	34409981	hsa-mir-1271	Diabetes Mellitus, Type 2	Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consistent functional down-regulation in post-mortem AD and T2D tissues.
other	34409922	hsa-mir-675	Liver Neoplasms	EGR1 and miR-675 were highly expressed, whereas sestrin 3 (SESN3) was poorly expressed in LC tissues and cells. miR-675 upregulation promoted the malignance of LC cells, but further upregulation of SESN3 reduced invasiveness of cells.
lncRNA target	34409897	hsa-mir-30	Pancreatic Carcinoma	5p/FSCN1 ceRNA crosstalk, in regulating pancreatic carcinogenesis and provided that inhibition of circ_0099999 might have therapeutic benefits in pancreatic cancer.
genetics_overexpression_promote	34409798	hsa-mir-17	Squamous Cell Carcinoma of Head and Neck	5p or silencing ACOX1 could reverse the effects of circ_0005379 overexpression on the proliferation, apoptosis, migration, and invasion of OSCC cell lines.
circulation_biomarker_diagnosis_ns	34409736	hsa-mir-4496	Carcinoma, Hepatocellular	Mechanistic investigations found that CCAT2 involved in HCC by regulating miR-4496/Atg5 in cytoplasm.
other	34409560	hsa-mir-137	Medulloblastoma	This study can conclude that miR-137 may be used as a prognostic biomarker of MB.
genetics_knock down_promote	34409524	hsa-mir-149	Stomach Neoplasms	5p inhibitor or LDHA overexpression could reverse the suppression effect of circ-DONSON knockdown on GC progression.
transcription factor target	34409072	hsa-mir-494	Cardiovascular Diseases	Hsa-miR3p may serve as a potential therapeutic target for EH and AF patients in the future.
other	34409031	hsa-mir-543	Carcinoma, Hepatocellular	Mechanistically, CRNDE enhanced the stability of ATG4B mRNA by sequestrating miR-543, leading to the elevation of ATG4B and autophagy in HCC cells.
other	34408781	hsa-mir-143	Heart Failure	The process is regulated by LncRNA-MiR143HG/miR-143, which may be one of its important mechanisms for the treatment of chronic heart failure.
genetics_overexpression_promote	34408781	hsa-mir-143	Drug-Related Side Effects and Adverse Reactions	This research cultured H9C2 cardiomyocytes and divided them into the normal control group, LncRNA-MiR143HG overexpression group, LncRNA-MiR143HG silence group, Adriamycin (ADR) group, ADR medicated serum group, ADR LncRNA-MiR143HG overexpression medicated serogroup, and ADR LncRNA-MiR143HG silence medicated serogroup.
lncRNA target	34408494	hsa-mir-148a	Colonic Neoplasms	miR-148a-3p played the similar effect of si-SERPINE1 that suppressed the COAD progression.
other	34408477	hsa-mir-222	Carcinoma, Hepatocellular	The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients.
other	34408477	hsa-mir-93	Carcinoma, Hepatocellular	The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients.
other	34408477	hsa-mir-221	Carcinoma, Hepatocellular	The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients.
target gene	34408438	hsa-mir-224	Lung Neoplasms	Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis.
exosome	34408418	hsa-mir-610	Endometriosis	EMs-pMphi-exo shuttled lncRNA CHL1-AS1 to promote eESC proliferation, migration, and invasion and inhibit apoptosis by downregulating miR-610 and upregulating MDM2. CONCLUSION: The results demonstrate that exosomal lncRNA CHL1-AS1 promotes the proliferation, migration, and invasion of eESCs and inhibits their apoptosis by downregulating miR-610 and upregulating MDM2, which might be a potential therapeutic target for EMs.
lncRNA target	34408135	hsa-mir-200a	Colorectal Neoplasms	Visceral adipose-derived factors promote vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming CRC cells into a highly metastatic phenotype.
lncRNA target	34407854	hsa-mir-1	Developmental Dysplasia of the Hip	In a previous study, high-throughput miRNA sequencing of tissue samples from an animal model of DDH showed a low level of miR
genetics_overexpression_promote	34407841	hsa-mir-342	Osteosarcoma	3p on the DXR resistance of OS cells also could be reversed by FBN1 overexpression.
lncRNA target	34407684	hsa-mir-424	Acute Kidney Injury	CONCLUSIONS: CASC9 alleviates LPS-induced AKI in vivo and in vitro, and CASC9 directly targets miR5p and further promotes the expression of TXNIP.
lncRNA target	34407675	hsa-mir-106b	Rhinitis, Allergic	Then transfected SNHG16 shRNA alone or together with miR-106b-5p antagomir into the AR cell model, we found that silencing the expression of SNHG16 down-regulated the expression of LIF and inhibited the activity of the JAK1/STAT3 pathway, cell apoptosis, and inflammation.
lncRNA target	34407056	hsa-mir-3171	Uterine Cervical Neoplasms	Further, mechanistically investigation revealed that ALOX12-AS1 could interact with AGO2 and sponge miR-3171, thereby antagonizing its' repression of tumor suppressor phosphatase and tensin homolog expression in cervical cancer cell.
lncRNA target	34407055	hsa-mir-195	Carcinoma, Hepatocellular	Taken together, our data provide strong evidence that HMGA1 promotes HCC and is negatively regulated by the tumor-suppressor, miR
circRNA target	34407051	hsa-mir-519	Esophageal Squamous Cell Carcinoma	Hsa_circ_0014879 silencing enhanced the radiosensitivity of ESCC via regulating the miR
genetics_knock down_promote	34407050	hsa-mir-502	Carcinoma, Renal Cell	Circ_0005875 knockdown suppressed RCC progression by regulating miR
genetics_overexpression_promote	34407049	hsa-mir-377	Osteosarcoma	Furthermore, CPEB1 overexpression could overturn the suppressive impacts of miR
genetics_knock down_promote	34407047	hsa-mir-338	Uterine Cervical Neoplasms	Additionally, the loss-of-functional experiments implied that knockdown of circASAP1 impeded proliferation, migration, and invasion while induced apoptosis and cell cycle arrest in cervical cancer cells along with repressed tumor growth in vivo through regulation of miR
genetics_knock down_promote	34406744	hsa-mir-21	Ovarian Neoplasms	It was further tested in live human ovarian cancer (SKOV3) and noncancerous (HEK 293T) cells to exemplify in situ PA activation based on differences in endogenous miR-21 regulation (p = 0.0002).
other	34406553	hsa-mir-590	Hypertrophy	5p modulates myocardium hypertrophy and myocyte apoptosis in HF by downregulating RTN4.
other	34406553	hsa-mir-590	Heart Failure	5p modulates myocardium hypertrophy and myocyte apoptosis in HF by downregulating RTN4.
lncRNA target	34406548	hsa-mir-378	Neuralgia	miR-378 acts as an inhibitor in the progression of neuropathic pain via targeting EZH2; the miR-378/EZH2 axis may be a novel target for the diagnosis and therapy of neuropathic pain in clinical treatment.
genetics_overexpression_promote	34406448	hsa-mir-10a	Endometrial Neoplasms	Transwell assay analysis showed that circ-ATAD1 overexpression totally reversed the enhancing effects of miR-10a on EC cell invasion and migration.
circulation_biomarker_diagnosis_ns	34405969	hsa-mir-9a	Carcinoma, Hepatocellular	The Kaplan-Meier method was applied to analyze three-year survival, Cox univariate regression was used to analyze the risk factors for recurrence of cirrhotic portal hypertension, and the receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of serum miR-9a-5p, total bilirubin (TBIL) and platelet (PLT) levels in patients with recurrence.
circulation_biomarker_diagnosis_ns	34405969	hsa-mir-9a	Hypertension, Portal	The Kaplan-Meier method was applied to analyze three-year survival, Cox univariate regression was used to analyze the risk factors for recurrence of cirrhotic portal hypertension, and the receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of serum miR-9a-5p, total bilirubin (TBIL) and platelet (PLT) levels in patients with recurrence.
circRNA target	34405943	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	In conclusion, our study revealed that silencing of circ_0000517 improved the progression of NSCLC through regulating miR5p/YY1 axis.
circulation_biomarker_diagnosis_ns	34405820	hsa-mir-224	Carcinoma, Hepatocellular	RESULTS: It was found miR-224 was elevated in both tissue and serum of HCC patients.
lncRNA target	34405716	hsa-mir-128	Chronic Constipation	In conclusion, our study demonstrated that miR-128 regulated the p38alpha/M-CSF signaling pathway to promote chronic inflammatory responses and changes in the immune microenvironment of the colon, thereby offering potential insights into the pathogenesis of CC and therapeutic targets for its treatment.NEW & NOTEWORTHY In this study, we constructed a murine model and identified a novel signaling mechanism involved in the chronic constipation progression. Our findings on the role of miR-128/p38alpha/M-CSF axis provide new insights into the treatment of chronic constipation.
lncRNA target	34405537	hsa-mir-17	Colorectal Neoplasms	Our results demonstrated that NBPF4 downregulated EZH2 and stabilized itself by binding to ZFP36, thus escaping from inhibition by miR3p, which allowed mitigation of CRC through inhibition of ETFA.
exosome	34405380	hsa-mir-34a	Colorectal Neoplasms	Tumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition.
other	34405027	hsa-mir-338	Carcinoma, Ovarian Epithelial	3p could serve as prognosis biomarkers for epithelial ovarian cancer.
genetics_overexpression_promote	34405022	hsa-mir-101	Carcinoma, Pancreatic Ductal	Further study showed that miRNA-101 level was decreased in PDAC tissues and cells, which could be responsible for DNA-PKcs overexpression and DNA-PKcs mediated oncogenic actions in PDAC cells.
genetics_knock down_promote	34404391	hsa-mir-183	Uterine Cervical Neoplasms	5p overexpression in suppressing cervical cancer development and angiogenesis.
lncRNA target	34403779	hsa-mir-2467	Carcinoma, Non-Small-Cell Lung	Presently, LINNC01224 expression was elevated and miR-2467 expression was down-regulated in NSCLC, compared with standard control. To sum up, LINC01224 can promote tumor progression and CDDP resistance in NSCLC via sponging miR-2467, suggesting a promising therapeutic target for better diagnosis and prognosis of NSCLC patients.
genetics_GWAS	34403773	hsa-mir-137	Alcoholism	CONCLUSION Our study suggests that MIR137HG genetic variants are associated with the alcohol-induced ONFH susceptibility in a Chinese male population, which may give scientific evidence for exploring molecular mechanisms of the alcohol-induced ONFH.
genetics_GWAS	34403773	hsa-mir-137	Femur Head Necrosis	CONCLUSION Our study suggests that MIR137HG genetic variants are associated with the alcohol-induced ONFH susceptibility in a Chinese male population, which may give scientific evidence for exploring molecular mechanisms of the alcohol-induced ONFH.
other	34403754	hsa-mir-29b-1	Aicardi-Goutieres syndrome 5	These novel findings provide evidence of a pathogenic anti-osteogenic role for miR-29b5p and other miRNAs in age-related defects in osteogenesis and bone regeneration.
epigenetics	34403663	hsa-mir-141	Meningitis, Bacterial	DNMT1 was involved in the methylation of miR-141 promoter in BM.
circRNA target	34403662	hsa-mir-212	Alzheimer Disease	induced apoptosis, inflammation, and oxidative stress via miR
lncRNA target	34403535	hsa-mir-369	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: FOXD1-AS1 elevates FOXD1 expression to promote OSCC malignant phenotypes through miR3p and ADAR.
genetics_overexpression_promote	34403532	hsa-mir-22	Breast Neoplasms	3p or overexpressing ERBB3.
genetics_overexpression_promote	34403518	hsa-mir-34a	Arthritis, Rheumatoid	Finally, we showed restoration of miR-34a-5p in TUG1-overexpressing FLSs-RA successfully overcame the TUG1-promoted glucose metabolism and apoptosis resistance via targeting LDHA.
other	34403363	hsa-mir-150	Heart Failure	However, mechanisms that regulate cell-specific miR-150 expression and function in HF are unknown.
genetics_GWAS	34403295	hsa-mir-146a	Behcet Syndrome	BACKGROUND A meta-analysis was performed by summarizing relevant researches to evaluate the relationship between miRNA-146a gene polymorphism rs2910164 and Behcet's disease (BD). CONCLUSION In conclusion, this meta-analysis indicates that miRNA-146a gene polymorphism rs2910164 G allele confers BD susceptibility, especially in Caucasians.
lncRNA target	34403009	hsa-mir-1277	Coronary Artery Disease	LINC01123 is highly expressed in CAS patients, and promotes cell proliferation and migration via regulating miR
genetics_overexpression_promote	34402705	hsa-mir-20b	Pancreatitis	Overexpression of miR-20b-5p restrained inflammation and apoptosis in Cer-LPS treated pancreatic acinar cells.
genetics_knock down_promote	34402683	hsa-mir-542	Breast Neoplasms	circ_RPPH1 knockdown or miR
other	34401471	hsa-mir-140	Urinary Bladder Neoplasms	Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis.
circulation_biomarker_diagnosis_up	34401317	hsa-mir-20	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	We analysed the plasma miR
genetics_knock down_promote	34400892	hsa-mir-508	Cholesteatoma, Middle Ear	Gain and loss of functions of miR
circulation_biomarker_diagnosis_ns	34400887	hsa-mir-452	Diabetes Mellitus, Type 2	MiR-34a-5p and miR5p: The Novel Regulators of Pancreatic Endocrine Dysfunction in Diabetic Zucker Rats? Objective: The pancreatic endocrinal system dominates the regulation of blood glucose levels in vivo, and the dysfunction of pancreatic endocrine -cells is a major cause of the occurrence and development of Type 2 diabetes (T2D).
circulation_biomarker_diagnosis_ns	34400887	hsa-mir-34a	Diabetes Mellitus, Type 2	MiR-34a-5p and miR5p: The Novel Regulators of Pancreatic Endocrine Dysfunction in Diabetic Zucker Rats? Objective: The pancreatic endocrinal system dominates the regulation of blood glucose levels in vivo, and the dysfunction of pancreatic endocrine -cells is a major cause of the occurrence and development of Type 2 diabetes (T2D).
other	34400675	hsa-mir-181c	Hyperemia	Our results demonstrated a ceRNA network consisting of lncRNA-DLEU2, miR-181c-5p and NCAPG, which played an important role in hyperoxia-induced apoptosis of vascular endothelial injury.
genetics_overexpression_suppress	34400241	hsa-mir-132	Alzheimer Disease	Overexpressed FOXA1 rescued the effect of elevated miR-132 in AD rats with sevo treatment.
genetics_knock down_promote	34399990	hsa-mir-619	Colorectal Neoplasms	Studies on gain-of-function and loss-of-function further testified that knockdown of LINC00882 or up-regulation of miR
genetics_knock down_promote	34399848	hsa-mir-193a	Uterine Cervical Neoplasms	Gain- and loss-of functional assays of FBXL19-AS1 and miR-193a-5p were performed in CC cell lines in vitro or in vivo.
circulation_biomarker_prognosis_ns	34399782	hsa-mir-543	Carcinoma, Non-Small-Cell Lung	RESULTS: LncRNA MEG3 was low in peripheral blood and tissues, while miR-543 was high (P < 0.05); both had good diagnostic values for NSCLC (P < 0.05).
other	34399167	hsa-mir-21	Breast Neoplasms	Herein, we developed a novel kind of electrochemical microRNA biosensor based on two-dimensional nanomaterial of antimonene nano-flakes (AMNFs) and carbon quantum dots (CQDs) which were used as substrating to cadmium ion (Cd(2+)) for specific detection of breast cancer-relevant biomarker-microRNA-21.
other	34399097	hsa-mir-7	Spinal Cord Injuries	These findings suggest that miR-7 could be developed as a potential treatment for SCI in human.
other	34398996	hsa-let-7g	beta-Thalassemia	Further, the results also indicate toward a critical role of let7 miRNAs in the pathogenesis of pediatric beta-thalassemia, which needs to be investigated further.
genetics_knock down_promote	34398060	hsa-mir-486	Muscular Atrophy	RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
lncRNA target	34398060	hsa-mir-486	Sarcopenia	CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
genetics_knock down_promote	34398060	hsa-mir-486	Death	RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
genetics_knock down_promote	34398060	hsa-mir-486	Congenital amegakaryocytic thrombocytopenia	RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
lncRNA target	34398060	hsa-mir-486	Mitochondrial Diseases	CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
lncRNA target	34398060	hsa-mir-486	Leukopenia	CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway.
circulation_biomarker_diagnosis_ns	34398018	hsa-mir-499	Myocardial Infarction, Acute	It also indicated a sensitivity [0.84 (95% CI: 0.70--0.92)] and specificity [0.97 (95% CI: 0.87--0.99)] of miR-499 for AMI. CONCLUSIONS: Circulating miR-1, miR-133, miR-208, and miR-499 showed diagnostic values in AMI.
lncRNA target	34397934	hsa-mir-145	Ovarian Neoplasms	Through bioinformatics analysis, we further explored the mechanism of miRNA-145 in ovarian cancer and related pathways.
circulation_biomarker_diagnosis_up	34396445	hsa-mir-10a	Osteoporosis	The relative expression levels of GAS5 and miR10a3p in the serum samples of patients with osteoporosis, as well as the relative expression levels of GAS5, microRNA (miR)10a3p and vascular endothelial growth factor A (VEGFA) mRNA in osteoblasts, were detected by reverse transcriptionquantitative PCR. GAS5 was significantly downregulated and miR10a3p was upregulated in patients with osteoporosis.
other	34396444	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	In summary, CuB reduced the proliferation of GR PC9 cells by modulating the miR175p/STAT3 axis, and may represent a promising potential novel strategy for the reversal of GR.
transcription factor target	34396443	hsa-mir-125a	Cardiovascular Diseases	The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases.
transcription factor target	34396443	hsa-mir-7	Vascular Diseases	The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases.
transcription factor target	34396443	hsa-mir-125a	Vascular Diseases	The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases.
transcription factor target	34396443	hsa-mir-7	Cardiovascular Diseases	The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases.
genetics_knock down_promote	34396434	hsa-mir-532	Colorectal Neoplasms	In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5FU via sponging miR5323p.
genetics_knock down_suppress	34396433	hsa-mir-4306	Colorectal Neoplasms	The inhibitory effects of FoxD2AS1 silencing on CRC progression were reversed by miR4306 knockdown.
transcription factor target	34396430	hsa-mir-25	Intervertebral Disc Degeneration	Overall, the results of the present study demonstrated that miR25 could promote the proliferation and inhibit the apoptosis of NPCs via targeting SUMO2, suggesting that miR25 may be a potential target in the treatment of IVDD.
genetics_knock down_promote	34396427	hsa-mir-8063	Colorectal Neoplasms	These results suggest that as a tumor suppressor, miR8063 is involved in regulating the selfrenewal of CRCSCs, where loss of miR8063 expression weakens its inhibition on hnRNPAB, which leads to the activation of Wnt/betacatenin signaling to promote the selfrenewal of CRCSCs.
other	34395911	hsa-mir-185	Hepatitis C	This article was designed to explore the effects and mechanisms of miR5p on the replication of hepatitis C virus (HCV).
lncRNA target	34395629	hsa-mir-339	Laryngeal Neoplasms	5p can inhibit the autophagy to decrease the cisplatin resistance of laryngeal carcinoma via targeting TAK1.
transcription factor target	34395626	hsa-mir-483	Glioblastoma	We also identified several CD163-associated kinase, miRNA, and transcription factor targets in GBM, including LCK, miR-483, and ELF1.
other	34395419	hsa-mir-223	Prostatic Neoplasms	CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression.
genetics_overexpression_promote	34395415	hsa-mir-1	Carcinoma, Hepatocellular	What is more, ORC6 overexpression counteracted the biological functions of miR
other	34395263	hsa-mir-5197	Colorectal Neoplasms	A Genome-Scale CRISPR Knock-Out Screen Identifies MicroRNA-5197-5p as a Promising Radiosensitive Biomarker in Colorectal Cancer.
target gene	34395239	hsa-mir-124	Colorectal Neoplasms	The critical role of the c-Myc/NEAT1 axis in mediating CRC response to PDT treatment via the miR-124/iASPP/p53 feedback loop was conclusively demonstrated.
lncRNA target	34395238	hsa-mir-638	Multiple Myeloma	Thus, this study aimed to further characterize the regulatory function of circ-PTK2 on cell malignant activities and its target microRNA-638 (miR-638) as well as downstream MEK/ERK, WNT/beta-catenin signaling pathways in MM. In conclusion, circ-PTK2 promotes cell proliferation, migration, suppresses cell apoptosis via miR-638 mediated MEK&ERK and WNT&beta-catenin signaling pathways in MM.
lncRNA target	34394903	hsa-mir-28	Leukemia, Myeloid, Acute	3p/CCND2 through MALAT1, resulting in Ara-C resistance in AML.
lncRNA target	34394829	hsa-mir-623	Substance Abuse, Intravenous	Here, we find that microRNA-623 (miR-623) is downregulated in IVDD and its expression is regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) under oxidative stress conditions. Thus, on elucidating the expression and functional mechanisms of miR-623, our study suggests that miR-623 can be a valuable therapeutic target for treating oxidative stress-induced IVDD.
other	34394340	hsa-mir-145	Neuralgia	5p, Atf3, Cacna2d1, Gal, and Ctss related to NP were validated by real-time PCR.
genetics_overexpression_promote	34394002	hsa-mir-344	Diabetes Mellitus	In cholesterol-stimulated and PA-induced diabetic beta-cell model, cholesterol-caused and PA-caused suppression on cell viability, increase in intracellular cholesterol level, decrease in GSIS, and increase in lip droplet deposition were dramatically attenuated via the overexpression of miR
other	34394002	hsa-mir-344	Pancreatic Diseases	Insulin receptor downstream MPAK/ERK signaling was involved in the protection of miR5p against cholesterol-induced pancreatic beta-cell dysfunction.
transcription factor target	34393805	hsa-mir-130a	Fibrous Dysplasia, Polyostotic	The miR-130a-3p/TGF-betaRII axis could suppress the differentiation of lung fibroblasts via the TGF-beta1/Smad signaling pathway, thereby reducing the process of PF.
lncRNA target	34393509	hsa-mir-513c	Thyroid Neoplasms	CONCLUSION: The TNRC6C-AS1/miR-513c-5p/LPAR5 axis is a novel signaling pathway that modulates THCA progression and may be a potential target for cancer therapy.
other	34392742	hsa-mir-27a	Essential Hypertension	3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.
other	34392742	hsa-mir-483	Essential Hypertension	3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways.
transcription factor target	34392240	hsa-mir-124	Parkinson Disease	3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation.
transcription factor target	34392240	hsa-mir-124	Neurogenic Inflammation	3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation.
lncRNA target	34391823	hsa-mir-148a	Ischemic Stroke	To summarize, this study demonstrated that lncRNA HOTAIR absorbed miR-148a-3p and up-regulated KLF6 expression through ceRNA mechanism, and inhibited STAT3 pathway, promoted apoptosis and inflammation, and aggravated neurological injury post-IS.
circulation_biomarker_diagnosis_ns	34391435	hsa-mir-184	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: The expression levels of miR-184 and miR5p derived from exosomes in the peripheral blood of NSCLC patients could be used as biomarkers to indicate osimertinib resistance.
circulation_biomarker_diagnosis_ns	34391435	hsa-mir-3913	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: The expression levels of miR-184 and miR5p derived from exosomes in the peripheral blood of NSCLC patients could be used as biomarkers to indicate osimertinib resistance.
other	34391433	hsa-mir-140	Urinary Bladder Neoplasms	LINC01410 leads the migration, invasion and EMT of bladder cancer cells by modulating miR-4319 / Snail1.
other	34390638	hsa-mir-9	Atrial Fibrillation	OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation.
other	34390638	hsa-mir-142	Atrial Fibrillation	OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation.
other	34390467	hsa-mir-122	Non-alcoholic Fatty Liver Disease	5p may play an important role in NAFLD.
exosome	34390377	hsa-mir-217	Urinary Bladder Neoplasms	CONCLUSION: These findings suggested that hBSC-derived exosomal miR-217 may act as oncogene in bladder cancer cells, and that Hippo-YAP signaling pathway maybe the target for miR-217 in the bladder cancer cell lines.
lncRNA target	34390329	hsa-mir-17	Prostatic Neoplasms	These results suggested that targeting circSMARCA5-miR-181b-5p-TIMP3 and circSMARCA5-miR3p-TIMP3 axis might be a novel therapeutic strategy for prostate cancer.
lncRNA target	34390329	hsa-mir-181b	Prostatic Neoplasms	These results suggested that targeting circSMARCA5-miR-181b-5p-TIMP3 and circSMARCA5-miR3p-TIMP3 axis might be a novel therapeutic strategy for prostate cancer.
genetics_knock down_promote	34390174	hsa-mir-142	Colorectal Neoplasms	3p inhibition weakened the impact of circ_0087862 knockdown on CRC cells.
other	34390171	hsa-mir-490	Hamartoma Syndrome, Multiple	Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31).
other	34390171	hsa-mir-1	Hamartoma Syndrome, Multiple	Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31).
other	34390171	hsa-mir-490	Sexually Transmitted Diseases	Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31).
other	34390171	hsa-mir-1	Sexually Transmitted Diseases	Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31).
lncRNA target	34389916	hsa-mir-200c	Triple Negative Breast Neoplasms	PURPOSE: To investigate the effectiveness of targeted ECO/miR-200c in modulating tumor microenvironment and treating triple negative breast cancer (TNBC) using non-invasive magnetic resonance molecular imaging (MRMI) of extradomain B fibronectin (EDB-FN) with a targeted MRI contrast agent.
lncRNA target	34389797	hsa-mir-214	Atrial Fibrillation	Taken together, the key findings of our study suggest that XIST may blunt myocardial pyroptosis by absorbing miR3p to promote Arl2 expression, providing encouraging insight into XIST-based targeted therapy for AF.
other	34389752	hsa-mir-126	Acute Kidney Injury	Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05).
other	34389752	hsa-mir-21	Acute Kidney Injury	Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05).
other	34389752	hsa-mir-192	Acute Kidney Injury	Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05).
other	34389752	hsa-mir-204	Acute Kidney Injury	Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05).
other	34389752	hsa-mir-141	Acute Kidney Injury	Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05).
other	34389732	hsa-mir-205	Hyperleptinemia	These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen.
other	34389732	hsa-mir-205	Breast Neoplasms	These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen.
other	34389732	hsa-mir-205	Obesity	These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen.
other	34389032	hsa-mir-155	Kidney Transplant Rejection	5p was a previously reported signature in KTR, whereas the remaining two were novel candidates both for KTR diagnosis and subtyping.
genetics_overexpression_promote	34389030	hsa-mir-27a	Squamous Cell Carcinoma of Head and Neck	RESULTS: In our study, we found overexpression of HPV E6 upregulated the expression of DGCR8 and miR-27a-3p in HNSCC cells.
genetics_overexpression_promote	34389030	hsa-mir-27a	Papillomavirus Infections	RESULTS: In our study, we found overexpression of HPV E6 upregulated the expression of DGCR8 and miR-27a-3p in HNSCC cells.
lncRNA target	34389018	hsa-mir-4640	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Taken together, we demonstrated that down-regulation of OGFRP1 inhibited the progression of NSCLC through miR
lncRNA target	34388692	hsa-mir-205	Stomach Neoplasms	3p as a tumor suppressor gene in gastric cancer (GC).
transcription factor target	34388478	hsa-mir-105	Carcinoma, Hepatocellular	Consistently, miR-105 upregulation inhibited the proliferation of HCC cells, while downregulation of miR-105 reversed Propofol-induced HCC cell apoptosis. CONCLUSION: Propofol significantly attenuated HCC tumorigenesis via mediation of miR-105/JAK2/STAT3 axis.
transcription factor target	34388475	hsa-mir-98	Stomach Neoplasms	DISCUSSION: All our results proved that OA could promote balance of Treg/Th17 cells in GC by targeting IL-6 with miR
other	34388112	hsa-mir-21	Colorectal Neoplasms	3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group.
other	34388112	hsa-mir-891a	Colorectal Neoplasms	3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group.
other	34388112	hsa-mir-194	Colorectal Neoplasms	3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group.
genetics_overexpression_promote	34388111	hsa-mir-221	Osteosarcoma	Further, in-vivo tests uncovered that overexpressing miR
other	34387972	hsa-mir-1281	Aortic Aneurysm, Abdominal	RESULTS: There was a hyperexpression of miRNA-1281 in patients with AAA and a significant reduction of it after EVAR, from 1.66-fold before EVAR to 0.27 after the procedure (P<0.0001). CONCLUSION: MiRNA-1281 may contribute as a possible marker of EVAR follow-up.
genetics_overexpression_promote	34387848	hsa-mir-143	Uterine Cervical Neoplasms	3p overexpression was also substantiated to inhibit the tumorigenicity of cervical cancer cells in vivo, while CDK1 overexpression counteracted their effect.
genetics_overexpression_promote	34387848	hsa-mir-495	Uterine Cervical Neoplasms	3p overexpression was also substantiated to inhibit the tumorigenicity of cervical cancer cells in vivo, while CDK1 overexpression counteracted their effect.
circRNA target	34387610	hsa-mir-223	Multiple Myeloma	3p/BRD4 pathway, which provided a new potential target for multiple myeloma chemoresistance.
circRNA target	34387609	hsa-mir-338	Nasopharyngeal Carcinoma	3p/SMAD5 axis, providing potential targets for improving the treatment of chemoresistant NPC.
circRNA target	34387608	hsa-mir-646	Carcinoma, Non-Small-Cell Lung	Circ-RNF121 and SOX4 were increased, and miR-646 was declined in DDP-resistant NSCLC tissues and cells. Circ-RNF121 silencing could reduce the DDP resistance of NSCLC cells by regulating SOX4 expression via miR-646.
lncRNA target	34387601	hsa-mir-885	Stomach Neoplasms	3p/CHD7 axis, which might be a novel strategy to inhibit gastric cancer progression.
lncRNA target	34387599	hsa-mir-515	Prostatic Neoplasms	Thus, we came a conclusion that circFOXM1 contributed to PCa progression via regulating miR5p/ADAM10 axis.
genetics_knock down_suppress	34387598	hsa-mir-873	Breast Neoplasms	Circ_0085495 knockdown reduced ADM resistance in ADM-resistant cells through modulating miR
lncRNA target	34387594	hsa-mir-141	Carcinoma, Renal Cell	3p could regulate CCRCC cell proliferation, migration, invasion and apoptosis by targeting NEK6.
genetics_overexpression_promote	34387591	hsa-mir-34c	Colorectal Neoplasms	In addition, MSI1 was a target of circ_KIAA1199, and the inhibitory effects of miR-34c-5p restoration on CRC cell proliferation, survival, migration and invasion were reversed by MSI1 overexpression. Circ_KIAA1199 functioned as an oncogene to drive the malignant development of CRC by activating MSI1 via competitively targeting miR-34c-5p.
genetics_overexpression_suppress	34387590	hsa-mir-214	Retinoblastoma	Overexpression of miR
other	34387138	hsa-mir-635	Triple Negative Breast Neoplasms	The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC.
other	34387138	hsa-mir-1250	Triple Negative Breast Neoplasms	The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC.
other	34387138	hsa-mir-1273	Triple Negative Breast Neoplasms	The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC.
other	34386930	hsa-mir-4458	Carcinoma, Non-Small-Cell Lung	The results showed that the expression level of miR-4458 decreased and STAT3 increased in NSCLC tissues and cells.
other	34386667	hsa-mir-204	Glomerulonephritis, IGA	However, there was no difference in miR-204 expression between IgAN and non-IgAN chronic kidney disease controls. CONCLUSION: Additional large-scale studies are now needed to validate the additive value of miR-204 in improving risk prediction in IgAN and more broadly in chronic kidney disease.
other	34386496	hsa-mir-21	Osteosarcoma	Downregulated lncRNA GAS5 and Upregulated miR-21 Lead to Epithelial-Mesenchymal Transition and Lung Metastasis of Osteosarcomas.
circulation_biomarker_diagnosis_up	34386495	hsa-mir-665	Epidermodysplasia Verruciformis	Finally, compared with that of the control group, miR-665 was highly expressed in serum samples in the aging and EVA groups, especially in the EVA groups. Collectively, in the aging and EVA groups, miR-665 expression was negatively correlated with lncRNA GAS5 and SDC1 expression.
lncRNA target	34386494	hsa-mir-196	Liver Neoplasms	Further, MAFG-AS1 promotes growth and migration of HCC by upregulating STRN4 through absorbing miR-3196.
genetics_knock down_suppress	34386489	hsa-mir-1205	Prostatic Neoplasms	Underexpression of miR-1205 is observed when NED is induced in vitro and inhibition of miR-1205 leads to increased expression of NED markers. However, while FRYL is overexpressed during NED, FRYL knockdown did not reduce NED, therefore revealing that miR-1205 induces NED independently of FRYL.
target gene	34386427	hsa-mir-23a	prostate carcinoma	The Circular RNA circXPO1 Promotes Tumor Growth via Sponging MicroRNA-23a in Prostate Carcinoma.
genetics_overexpression_promote	34386421	hsa-mir-200b	Esophageal Squamous Cell Carcinoma	CCAT2 promoted the migration and invasion of ESCC cells in vitro, and tumorigenesis in vivo by upregulating TK1 expression, while overexpression of miR-200b reversed these effects of CCAT2.
circulation_biomarker_diagnosis_down	34386414	hsa-mir-125b	Carcinoma, Hepatocellular	These findings highlight that circulating exosomal miR-125b might represent a reliable biomarker with diagnostic and therapeutic implications for extrahepatic metastasis from HCC.
lncRNA target	34386303	hsa-mir-204	Diabetes Mellitus	CONCLUSION: NEAT1 regulated the development of EMT in DR through miR-204/SOX4 pathway, which could provide reference for clinical prevention and treatment.
genetics_knock down_suppress	34386091	hsa-mir-542	Osteosarcoma	lncRNA XLOC_005950 knockout may inhibit the progression of OS via hsa-miR-542-3p-mediated regulation of PFKM expression.
lncRNA target	34386082	hsa-mir-1298	Breast Neoplasms	5p was demonstrated to inhibit the proliferation, adhesion and migration of BC cells and to promote BC cell apoptosis.
genetics_overexpression_promote	34386074	hsa-mir-1303	Carcinoma, Non-Small-Cell Lung	In summary, the findings from this study suggested that LINC01272 expression, which was decreased in NSCLC tumor tissues and NSCLC cells, may be used as an independent prognostic biomarker for patients with NSCLC and that its overexpression may suppress NSCLC cell proliferation, migration and invasion by inhibiting miR-1303.
genetics_knock down_promote	34386071	hsa-mir-133a	Colorectal Neoplasms	Furthermore, AQP1-knockdown induced, while overexpression reversed, the suppressive effects of miR-133a-3p on CRC cells.
other	34386062	hsa-mir-383	Glioma	Rescue experiments confirmed that the lnc-NLC1-C/miR-383/PRDX-3 axis was involved in the molecular mechanism of glioma progression.
other	34385927	hsa-mir-449a	Gastroparesis, Diabetic	Collectively, our data highlight a novel regulatory signaling pathway, the MALAT1/miR-449a/DLL1 axis, in the context of DGP.
lncRNA target	34385891	hsa-mir-20a	Stomach Neoplasms	Wnt/beta-catenin pathway and EMT in GC cells were suppressed by LOC100505817 through miR-20a-inhibted WT1. In summary, our results provided evidence suggesting that LOC100505817 inhibits GC through LOC100505817-mediated inhibition of Wnt/beta-catenin pathway, that leads to the overall restraining of GC cell proliferation, migration and invasion through miR-20a-reduced WT1.
other	34385599	hsa-mir-486	Ataxia with vitamin E deficiency	5p together (p < 0.01), were associated with ADT response.
other	34385599	hsa-mir-21	Ataxia with vitamin E deficiency	5p together (p < 0.01), were associated with ADT response.
other	34385308	hsa-mir-122	Hepatitis C	Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with a liver-specific microRNA called miR-122.
lncRNA target	34384932	hsa-mir-128	Obesity	Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes.
lncRNA target	34384932	hsa-mir-128	Diabetes Mellitus, Type 2	Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes.
transcription factor target	34384932	hsa-mir-128	Mitochondrial Diseases	Also, miR-128 is shown to promote mitochondrial dysfunction by directly targeting NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (NDUFS4).
lncRNA target	34384932	hsa-mir-128	Metabolic Diseases	Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes.
lncRNA target	34384839	hsa-mir-126	Coronary Artery Disease	CONCLUSION: LncRNA CDKN2B-AS1 upregulates PTPN7 by absorbing miR5p and inhibits the PI3K-Akt pathway, thus hindering the proliferation and accelerating apoptosis of VSMCs induced by ox-LDL, thus being a therapeutic approach for CAS.
other	34384839	hsa-mir-126	Coronary Disease	METHODS: Microarray analyses were performed to screen out the CHD-related lncRNAs (CDKN2B-AS1) and the downstream microRNAs (miR5p).
other	34384839	hsa-mir-126	Inflammation	Then pcDNA-CDKN2B-AS1 and/or miR5p mimic were transfected into ox-LDL-treated VSMCs to estimate cell proliferation, apoptosis and inflammation.
exosome	34384713	hsa-mir-25	Carcinoma, Hepatocellular	derived exosomes promoted the development of HCC by reducing SIK1 expression and potentiating the Wnt/beta-catenin pathway.
lncRNA target	34384283	hsa-mir-215	Wilms Tumor	Moreover, transfection of pcDNA3.1-CRK in G401 and WT-CLS1 cells could partially reverse the inhibitory effect of miR
lncRNA target	34384196	hsa-mir-34	Uterine Cervical Neoplasms	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-375	Spherocytosis, Type 1	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-375	Uterine Cervical Neoplasms	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
other	34384196	hsa-mir-205	Spherocytosis, Type 1	miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples.
other	34384196	hsa-mir-205	Squamous Intraepithelial Lesions	miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples.
lncRNA target	34384196	hsa-mir-34	Disease	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-34	Spherocytosis, Type 1	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-34	Squamous Intraepithelial Lesions	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-29	Disease	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-29	Spherocytosis, Type 1	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-203	Squamous Intraepithelial Lesions	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-29	Uterine Cervical Neoplasms	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
circulation_biomarker_diagnosis_up	34384196	hsa-mir-21	Disease	Among the miRNAs, miR-21 is the most prevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stages in both cell and serum samples.
lncRNA target	34384196	hsa-mir-29	Squamous Intraepithelial Lesions	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-203	Disease	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
circulation_biomarker_diagnosis_up	34384196	hsa-mir-21	Uterine Cervical Diseases	Among the miRNAs, miR-21 is the most prevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stages in both cell and serum samples.
other	34384196	hsa-mir-205	Papillomavirus Infections	miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples.
lncRNA target	34384196	hsa-mir-375	Squamous Intraepithelial Lesions	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-375	Disease	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-let-7	Disease	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-let-7	Squamous Intraepithelial Lesions	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-let-7	Spherocytosis, Type 1	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-let-7	Uterine Cervical Neoplasms	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
other	34384196	hsa-mir-205	Disease	miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples.
lncRNA target	34384196	hsa-mir-203	Spherocytosis, Type 1	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
lncRNA target	34384196	hsa-mir-203	Uterine Cervical Neoplasms	The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer.
other	34383804	hsa-mir-29a	Rhinitis, Allergic	RESULTS: 1 in circleCompared with healthy controls, miR-29a expression was up-regulated and FOS mRNA expression was down-regulated in the nasal tissues from the patients with allergic rhinitis (AR). CONCLUSION: MiR-29a-/FOS axis can be regarded as a potential marker and a new therapy for AR.
lncRNA target	34383714	hsa-mir-186	HIV-Associated Lipodystrophy Syndrome	Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations.
lncRNA target	34383714	hsa-mir-20a	HIV-Associated Lipodystrophy Syndrome	Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations.
lncRNA target	34383714	hsa-mir-24	HIV-Associated Lipodystrophy Syndrome	Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations.
lncRNA target	34383404	hsa-mir-20a	Urinary Bladder Neoplasms	MiR 20a plays an oncogenic role in bladder cancer, which contributes to target LASS2 directly.
other	34383354	hsa-mir-206	Diabetic Retinopathy	PPF modulated MALAT1/miR-206/ATG3 axis to protect cardiomyocytes against I/R injury.
exosome	34382916	hsa-mir-527	Ovarian Neoplasms	Our study demonstrated that silencing circ_C20orf11 sensitizes ovarian cancer to DDP by promoting miR-527/YWHAZ signaling and EV-mediated macrophage M2 polarization.
circulation_biomarker_diagnosis_up	34382731	hsa-mir-155	Osteoporosis	In the present study, we collected serum samples from 10 clinical osteoporosis patients to detect long noncoding RNA-neighboring enhancer of FOXA2 (lncRNA-NEF) and miR-155 expression levels. The level of lncRNA-NEF was downregulated, and miR-155 was upregulated, in serum samples from patients with clinical osteoporosis.
transcription factor target	34382727	hsa-mir-221	Breast Neoplasms	Our study not only identified miRNA-221 as a pivotal factor conferring the acquired resistance of HER2-positive breast cancer cells to lapatinib through negatively regulating p27(kip1) expression, but also suggested Src inhibition as a potential strategy to overcome lapatinib resistance.
epigenetics	34382305	hsa-mir-9-1	Nasopharyngeal Carcinoma	In NPC cells, hypermethylation regulates miR
lncRNA target	34382070	hsa-mir-126	Endometriosis	Our study revealed the METTL3/m6A/miR126 pathway, whose inhibition might contribute to endometriosis development by enhancing cellular migration and invasion.
circulation_biomarker_diagnosis_ns	34381972	hsa-mir-486	Atherosclerosis	Lastly, profiling microRNA in BMDM-HG-exo and plasma EVs from diabetic subjects with advanced atherosclerosis converged on miR5p as commonly enriched and recognized in dysregulated hematopoiesis and Abca1 control.
genetics_knock down_promote	34381816	hsa-mir-26a	Uveal melanoma	The knockout of EZH2 mimicked the tumor inhibition of miR-26a in UM cells, whereas the reintroduction of EZH2 abolished this effect.
other	34381778	hsa-mir-139	Depression	CONCLUSION: These results provide important evidence that emodin may be a candidate agent for the treatment of depression and established a key role of miR5p/5-LO in the inflammation of depression.
genetics_knock down_promote	34381772	hsa-mir-645	Colorectal Neoplasms	In addition, TGFBR2 was a target of miR-645, and miR-645 inhibition-suppressed CRC cell proliferation, migration/invasion and glycolysis were restored by TGFBR2 knockdown. CircFAM120B inhibited CRC progression partly by mediating the miR-645/TGFBR2 network, which explained the potential mechanism of circFAM120B function in CRC.
lncRNA target	34381729	hsa-mir-503	Stomach Neoplasms	METHODS: The bioinformatics analysis was performed to examine the expression status of cancer associated genes in patients with stomach adenocarcinoma (STAD) and predict the targeting sites of miR5p with LncRNA MIR503HG and TUSC3.
lncRNA target	34381729	hsa-mir-224	Stomach Neoplasms	CONCLUSIONS: Targeting the LncRNA MIR503HG/miR
other	34381702	hsa-mir-641	Glioma	Taken together, the data indicated that COX10-AS1 acts as an oncogene in combination with COX10-AS1/miR-641/E2F6 in glioma, which may be beneficial to the diagnosis and treatment of glioma.
other	34381564	hsa-mir-7	Holoprosencephaly 7	MiR5p is a recently discovered downregulated miRNA in thyroid papillary carcinoma (PTC).
lncRNA target	34381564	hsa-mir-7	Thyroid Cancer, Papillary	5p inhibits thyroid cell proliferation by modulating the MAPK and PI3K signaling pathways which are both necessary for normal thyroid proliferation and play central roles in PTC tumorigenesis.
genetics_knock down_promote	34381502	hsa-mir-146b	Carcinoma, Hepatocellular	Moreover, miR-146b-5p suppression or CBX6 elevation evidently rescued the suppressed viability, migration, and invasion of HCC cells caused by MIR100HG knockdown.
lncRNA target	34381417	hsa-mir-223	Epilepsy, Temporal Lobe	These findings show that miR 223 affects microglial autophagy via ATG16L1 in the KA model of TLE.
transcription factor target	34381349	hsa-mir-339	Parkinson Disease	We identified 32 target genes of miR
circulation_biomarker_diagnosis_up	34381349	hsa-mir-96	Parkinson Disease	Our goal was to study two serum circulating microRNAs (miR
circulation_biomarker_diagnosis_up	34381349	hsa-mir-96	Multiple System Atrophy	Our goal was to study two serum circulating microRNAs (miR
transcription factor target	34381349	hsa-mir-339	Multiple System Atrophy	We identified 32 target genes of miR
genetics_overexpression_promote	34381025	hsa-mir-29b	Spinal Cord Injuries	Inhibition of miR-29b-3p or overexpression of PTEN reversed the repair effect of EVs on SCI.
transcription factor target	34381015	hsa-mir-223	Diabetes Mellitus	3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups.
transcription factor target	34381015	hsa-mir-7	Diabetes Mellitus	3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups.
transcription factor target	34381015	hsa-mir-145	Diabetes Mellitus	3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups.
transcription factor target	34381015	hsa-mir-24	Diabetes Mellitus	3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups.
circulation_biomarker_diagnosis_down	34380897	hsa-mir-491	Brain Injuries, Traumatic	5p downregulation promotes neovascularization, restores cerebral blood flow, and improves the recovery of neurological function after traumatic brain injury.
lncRNA target	34380584	hsa-mir-93	Thyroid Neoplasms	In addition, CCK-8, immunofluorescence, wound-healing and transwell assays were applied to demonstrate that SNHG14 promoted the proliferation, migration and invasion of thyroid tumour cells by targeting miR
circulation_biomarker_prognosis_up	34380511	hsa-mir-92b	Breast Neoplasms	CONCLUSION: miR-92b-3p expression obviously rises in the serum of BC patients and is closely related to the clinical staging, degree of differentiation, and CA125 in BC, so the detection of this miRNA is of great significance to the diagnosis and prognostic evaluation of BC.
circulation_biomarker_diagnosis_up	34380068	hsa-mir-140	Arthritis, Rheumatoid	Our results first demonstrated an increased expression of circulating miR-140 and serum leptin in PsA patients compared to RA, which were identified as potential additional biomarkers to discriminate PsA from RA.
circulation_biomarker_diagnosis_up	34380068	hsa-mir-140	Arthritis, Psoriatic	Our results first demonstrated an increased expression of circulating miR-140 and serum leptin in PsA patients compared to RA, which were identified as potential additional biomarkers to discriminate PsA from RA.
exosome	34378676	hsa-mir-21	Esophageal Neoplasms	The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or miR-21 mimics transfected-HEF in the transwell system.
genetics_overexpression_suppress	34378327	hsa-mir-149	Squamous Cell Carcinoma of Head and Neck	GACAT1 overexpression induced TSCC cell growth and migration via regulating miR-149 expression.
genetics_overexpression_promote	34378285	hsa-mir-134	Breast Neoplasms	5p overexpression could suppress BC tumor growth via targeting ARHGAP1 in vivo.
other	34378214	hsa-mir-135a	Asthenozoospermia	Low expression of JAK2 mRNA and high expression of miR-135a-5p were related to asthenozoospermia and male infertility.
circulation_biomarker_diagnosis_ns	34378123	hsa-mir-24	Thyroid Cancer, Papillary	RESULTS: We identified miR24-3p, miR146a-5p, miR181a-5p and miR382-5p with different expression levels in two different series of 56 and 58 PTC patients as compared with healthy controls. When comparing the expression levels of some PTC-specific exosomal miRNAs with those of the same miRNAs circulating free of any encapsulation, we found a significant correlation for only miR24-3p, suggesting that only select miRNAs are secreted in exosomes.
lncRNA target	34377430	hsa-mir-129	Intervertebral Disc Degeneration	5p relieved IDD via inhibition of the LRG1/p38 MAPK signaling in vivo.
lncRNA target	34377277	hsa-mir-153	Spinal Cord Injuries	CONCLUSION: We proved that miR-153 attenuated inflammatory response and oxidative stress induced by SCI by targeting of NEUROD2, indicating a protective role in SCI progression.
other	34377255	hsa-mir-148b	Osteosarcoma	LncRNA HCG18 promotes cell multiplication and metastasis by miR-148b/ETV5 regulation in osteosarcoma.
transcription factor target	34377252	hsa-mir-1307	Osteoarthritis	CONCLUSION: The suppression of miR
target gene	34377249	hsa-mir-136	Triple Negative Breast Neoplasms	Transfection with miRNA-136 can significantly inhibit the proliferation of TNBC cells by external transfection, and has little effect on cell apoptosis.
circulation_biomarker_prognosis_up	34377248	hsa-mir-29a	Sepsis-Associated Encephalopathy	CONCLUSION: miR-29a is closely associated with the development of SAE, and miR-29a in the peripheral blood can be used as a potential biological index to predict whether sepsis is complicated with SAE and indications of a poor prognosis.
exosome	34377236	hsa-mir-200b	Femur Head Necrosis	Collectively, our results showed that hsa-miR-200b-3p and hsa-miR-206 in urinary exosomes might serve as non-invasive biomarkers for SONFH.
exosome	34377236	hsa-mir-206	Femur Head Necrosis	Collectively, our results showed that hsa-miR-200b-3p and hsa-miR-206 in urinary exosomes might serve as non-invasive biomarkers for SONFH.
genetics_overexpression_promote	34377235	hsa-mir-296	Breast Neoplasms	5p inhibition or FOXP4 overexpression restored the malignant properties of circRPPH1-silenced BC cells.
lncRNA target	34377233	hsa-mir-221	Carcinoma, Renal Cell	5p/SOCS1 axis as a tumor suppressor in RCC.
other	34377228	hsa-mir-194	Epidermodysplasia Verruciformis	5p axis in apoptosis induced by EV71 infection, while no association with autophagy was observed.
other	34377051	hsa-mir-217	Esophageal Achalasia	Further analysis using qRT-PCR showed significant down-regulation of hsa-miR-217 (p-value = 0.004) in achalasia tissue.
genetics_overexpression_suppress	34377026	hsa-mir-577	Stomach Neoplasms	Finally, the results demonstrate the overexpression of miR-577 and the silence of RAB14 could inhibit the effects of circTMCO3 on proliferation, migration and invasion in GC cells.
lncRNA target	34377022	hsa-mir-1324	Stomach Neoplasms	CONCLUSION: Propofol exerted anticancer role in GC through regulating circPDSS1/miR-1324/SOX4 axis, indicating that propofol might be an effective therapeutic medicine for GC treatment.
transcription factor target	34377019	hsa-mir-455	pancreatic adenocarcinoma	3p in PAAD tissue was closely connected with poor prognosis, and only 5 target mRNAs were predicted to be increased in PAAD tissue with poor prognosis.
circRNA target	34377018	hsa-mir-1253	Carcinoma, Hepatocellular	CONCLUSION: Circ_0072995 exerted tumorigenic roles to enhance HCC progression through activating EIF4A3 by sponging miR-1253.
genetics_overexpression_promote	34376998	hsa-mir-765	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The overexpression of miR-765 in NSCLC was associated with TNM stage and poor prognosis of patients.
other	34376644	hsa-mir-942	Carcinoma, Hepatocellular	Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis.
lncRNA target	34376255	hsa-mir-29c	Inflammation	CONCLUSIONS: miR-29c-3p has potential as a biomarker for the diagnosis of sepsis, and inhibition of miR-29c-3p expression in animal models reduced sepsis-induced cardiac dysfunction and inflammatory response.
lncRNA target	34376255	hsa-mir-29c	Sepsis	CONCLUSIONS: miR-29c-3p has potential as a biomarker for the diagnosis of sepsis, and inhibition of miR-29c-3p expression in animal models reduced sepsis-induced cardiac dysfunction and inflammatory response.
other	34375951	hsa-mir-335	Osteoporosis	5p, were significantly higher expressed in osteoporotic patients compared with non-osteoporotic individuals.
exosome	34375914	hsa-mir-885	Transmissible Gastroenteritis	Overall, the results indicated that TGEV-ORF3b counteracted NF-kappaB pathway and TNF-alpha via regulating miR
genetics_knock down_promote	34375306	hsa-mir-335	Triple Negative Breast Neoplasms	3p or knockdown of WNT2 removed the promoted effects of lncRNA HAGLR on TNBC development.
tissue_expression_ns	34375168	hsa-mir-380	Spinal Cord Injuries	circTYW1 and FGF9 were poorly expressed, whereas miR-380 was highly expressed in the spinal cord tissues of SCI rats.
lncRNA target	34374893	hsa-let-7b	Colorectal Neoplasms	Moreover, the correlation analysis between LAMTOR5 and LAMTOR5-AS1 revealed a significant association in CRC (p value = 0.0074) which can be partly explained by its predicting act as a mediator with sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p. LAMTOR5-AS5 which is a nearby lncRNA of this gene could play a regulatory impact through its sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p which both have shown a significant impact on overall survival rate in CRC patients in high expression levels.
lncRNA target	34374893	hsa-mir-20a	Colorectal Neoplasms	Moreover, the correlation analysis between LAMTOR5 and LAMTOR5-AS1 revealed a significant association in CRC (p value = 0.0074) which can be partly explained by its predicting act as a mediator with sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p. LAMTOR5-AS5 which is a nearby lncRNA of this gene could play a regulatory impact through its sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p which both have shown a significant impact on overall survival rate in CRC patients in high expression levels.
other	34374662	hsa-mir-181a	Pancreatic Carcinoma	In the present study, we show that ANRIL was up-regulated while miR-181a was down-regulated in pancreatic cancer tissues and HMGB1 was highly expressed.
genetics_knock down_promote	34374639	hsa-mir-6736	Breast Neoplasms	3p inhibitor and NRP-1 overexpression could partly reverse the suppressive influence of RP11-70C1.3 knockdown on breast cancer chemoresistance.
genetics_knock down_promote	34374638	hsa-mir-122	Breast Neoplasms	Our data concluded that knockdown of CDKN2B-AS1 suppresses the progression of breast cancer by miR
other	34374576	hsa-mir-221	Carcinoma, Hepatocellular	miR-221 can be used as a promising prognostic biomarker of hepatocellular carcinoma.
transcription factor target	34374261	hsa-mir-335	Colonic Neoplasms	5p may inhibit the proliferation and promote apoptosis of colon cancer cells by targeting G6PD.
transcription factor target	34374235	hsa-mir-125b	Hemangioma	Conclusion: miR-125b-5p inhibits the proliferation of human hemangioma endothelial cells and induces apoptosis.
other	34373727	hsa-mir-934	Colorectal Neoplasms	miR-934/DDK2 axis regulated colorectal cancer cell proliferation
lncRNA target	34373722	hsa-mir-103a	Vascular Calcification	Therefore, it was concluded that miR-103a plays a notable role in the transdifferentiation of the VSMCs in high phosphorus-induced calcification by targeting the regulation of RUNX2, and may therefore constitute a new target for the diagnosis and treatment of vascular calcification.
target gene	34373706	hsa-mir-449a	Triple Negative Breast Neoplasms	MicroRNA-449a inhibits cell proliferation and migration by regulating mutant p53 in MDA-MB-468 cells.
genetics_overexpression_suppress	34373692	hsa-mir-124	Osteosarcoma	3p overexpression, which involved the derepression of sphingosine kinase 1 (SphK1).
genetics_overexpression_promote	34373436	hsa-mir-22	Osteosarcoma	To sum up, overexpressed MIR22HG inhibits the viability and proliferation of osteosarcoma cells, which was achieved via regulation of the miR
lncRNA target	34373133	hsa-mir-24	Aortic Aneurysm, Thoracic	CONCLUSION: NEAT1 could contribute to the malignant behaviors of TAA cells by targeting miR
genetics_knock down_promote	34372909	hsa-mir-126	Leukemia, Myeloid, Acute	Loss of miR-126(high) ECs led to a decreased EC miR-126 supply to LSCs, which then entered the cell cycle and promoted leukemia growth.
genetics_overexpression_promote	34372727	hsa-mir-204	Stomach Neoplasms	A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression.
genetics_overexpression_promote	34372727	hsa-mir-204	Down Syndrome	A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression.
exosome	34371055	hsa-mir-125b	Prostatic Neoplasms	5p were differentially expressed in mPCa exosomes.
exosome	34371055	hsa-mir-425	Prostatic Neoplasms	5p were differentially expressed in mPCa exosomes.
exosome	34371055	hsa-mir-205	Prostatic Neoplasms	5p were differentially expressed in mPCa exosomes.
exosome	34371055	hsa-mir-148a	Prostatic Neoplasms	5p were differentially expressed in mPCa exosomes.
lncRNA target	34370878	hsa-mir-98	Colorectal Neoplasms	Additionally, BCAT1 was proved to enhance cell progression as the target of miR
genetics_overexpression_promote	34370715	hsa-mir-138	Melanoma	The SIRT7 overexpression and miR
other	34370714	hsa-mir-205	Diabetic Foot	5p negatively regulated angiogenesis and wound healing in patients with diabetic foot.
other	34370714	hsa-mir-195	Diabetic Foot	5p negatively regulated angiogenesis and wound healing in patients with diabetic foot.
exosome	34370713	hsa-mir-326	Esophageal Squamous Cell Carcinoma	In general, exosomal LINC01711 promoted the proliferation, migration, and invasion of esophageal cancer cells by up-regulating FSCN1 and down-regulating miR-326, thus improved the occurrence and development of ESCC.
other	34370552	hsa-mir-136	Triple Negative Breast Neoplasms	In conclusion, circ-ERBB2 facilitated the Warburg effect and malignancy of TNBC cells by the miR5p/PDK4 pathway, at least in part.
genetics_overexpression_promote	34370360	hsa-mir-26a	Cardiomegaly	Overexpression of miR-26a-5p by type 9 recombinant adeno-associated virus (rAAV9) reversed the heart hypertrophic manifestations.
other	34370073	hsa-mir-638	Ovarian Neoplasms	5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer.
other	34370073	hsa-mir-16	Ovarian Neoplasms	5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer.
other	34370073	hsa-mir-17	Ovarian Neoplasms	5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer.
genetics_knock down_suppress	34370061	hsa-mir-873	Stomach Neoplasms	3p could attenuate the circRNA_0043691 knockdown on GC cells proliferation, migration, and invasion.
lncRNA target	34369711	hsa-mir-449a	Osteosarcoma	MiR-449a impeded the viability and proliferation of osteosarcoma cells and controlled the cell cycle through targeting cyclin D1 to reduce pRB phosphorylation.
circRNA target	34369654	hsa-mir-149	Uterine Cervical Neoplasms	Circ_0011385 elevates SOX4 expression by targeting miR
other	34369363	hsa-mir-22	Arthritis, Rheumatoid	RESULTS: The logistic regression results showed that miR-22 (p=0.0003) and miR-26a (p=0.049) may be the most important molecules distinguishing RA patients and healthy controls. Moreover, the quantity of miR-22 was different between rheumatoid factor (RF)-positive and RF-negative patients (p=0.04).
lncRNA target	34369270	hsa-mir-361	Carcinoma, Squamous Cell, Cutaneous	5p inhibition rescued the suppressing effects of NEAT1 depletion on cell proliferation, invasion as well as Wnt pathway in CSCC.
other	34369267	hsa-mir-1270	Adenocarcinoma of Lung	In brief, this study has demonstrated that GLIDR/miR-1270/TCF12 axis plays the crucial role in LUAD, which offers a new insight into researches on molecular mechanism concerning LUAD and provides with a new perspective for LUAD treatment.
lncRNA target	34369259	hsa-mir-448	Myocardial Reperfusion Injury	The AK006774/miR-448/bcl-2 signaling axis acts as a key regulator of I/R injury and may be a potential therapeutic or diagnostic target for the treatment of MI.
genetics_overexpression_promote	34369236	hsa-mir-146b	Carcinoma, Ovarian Epithelial	Finally, our data demonstrated that miR-146b overexpression resulted in a greater suppression of cell migration than STAT3 pathway inhibition alone.These results suggest a complex and heterogeneous role of EGFR in ovarian cancer.
other	34369163	hsa-mir-133a	Myocardial Infarction	Herein, a near-infrared light (NIR)-initiated PEC biosensor based on NaYF(4):Yb,Tm@NaYF(4)@TiO(2)@CdS (csUCNRs@TiO(2)@CdS) was constructed for sensitive detection of acute myocardial infarction (AMI)-related miRNA-133a in an immobilization-free format coupled with a hybridization chain reaction and a redox circle signal amplification strategy.
lncRNA target	34369082	hsa-mir-196b	Huntington Disease	Moreover, upregulated DNM3OS decreased the expression of miR-196b-5p by sponging, and GAPDH was a direct target of miR-196b-5p, playing an important pathogenic role in the formation of aggregates in the HD cell model. Our study uncovers a novel DNM3OS/miR-196b-5p/GAPDH pathway involved in the molecular pathogenesis of HD, which may offer a potential therapeutic strategy for HD.
genetics_knock down_promote	34369042	hsa-mir-425	Inflammation	5p overexpression attenuated neuronal apoptosis in the Rot-mediated PD model, TH-positive cell loss, and microglial activation by mitigating inflammation and oxidative stress.
genetics_knock down_promote	34369042	hsa-mir-425	Parkinson Disease	5p overexpression attenuated neuronal apoptosis in the Rot-mediated PD model, TH-positive cell loss, and microglial activation by mitigating inflammation and oxidative stress.
other	34369033	hsa-mir-181a	Osteoarthritis	SNHG5 and miR-181a-5p expression levels were then detected in cartilage tissues of osteoarthritis patients and C20/A4 cells by quantitative polymerase chain reaction (qPCR). The expression levels of SNHG5 and TGFBR3 were markedly decreased, and miR-181a-5p expression was enhanced in osteoarthritis tissues and chondrocytes treated with IL-1beta.
circRNA target	34368980	hsa-mir-139	Cystitis, Interstitial	5p/MFN2 axis indicating that circTHBS1 might be a potential target for IC treatment.
genetics_GWAS	34368922	hsa-mir-195	Leukemia, Myeloid, Acute	RESULTS We found that the expression of miR-195 was the lowest in cytogenetically normal (CN-) AML, and high expression of miR-195 only promoted the prognosis of chemotherapy-only CN-AML patients (EFS: P=0.016; OS: P=0.035).
other	34368874	hsa-mir-28	Colorectal Neoplasms	Moreover, the results herein revealed that the expression of miR285p was negatively correlated with that of CDKN2BAS1 in CRC tissue.
transcription factor target	34368871	hsa-mir-296	Colorectal Neoplasms	Together, the results of the present study suggested the potential importance of the miR2963p/GRINA axis and highlighted potential novel targets for the management of CRC.
genetics_knock down_promote	34368861	hsa-mir-128	Colorectal Neoplasms	Rescue experiments demonstrated that inhibiting miR1283p or upregulating E2F3 offset the effects of SNHG22 knockdown on CRC cells. The present findings support the existence of an interactive regulatory network involving SNHG22, miR1283p and E2F3 in CRC cell lines, indicating that the SNHG22/miR1283p/E2F3 axis may be considered a novel diagnostic and therapeutic target in CRC.
genetics_knock down_promote	34368370	hsa-mir-200c	Endometrial Neoplasms	Moreover, further study revealed that miR-200c-3p could bind to OIP5-AS1, and the loss function of miR-200c-3p could reverse the elevated OIP5-AS1's inhibitory effect on the progression of EC.
transcription factor target	34368354	hsa-mir-1228	Lung Diseases, Interstitial	GO and KEGG analyses suggested that several pathways may contribute the pathogenesis of DM-ILD-MDA5 Ab(+) and DM-nonILD-MSA16(-), while PPI network analysis of hsa-miR-4488 and hsa-miR5p indicated that their predicted target genes, DExD-box helicase 39B and MDM2, may be involved in the mechanisms of DM-ILD-MDA5 Ab(+).
transcription factor target	34368354	hsa-mir-4488	Lung Diseases, Interstitial	GO and KEGG analyses suggested that several pathways may contribute the pathogenesis of DM-ILD-MDA5 Ab(+) and DM-nonILD-MSA16(-), while PPI network analysis of hsa-miR-4488 and hsa-miR5p indicated that their predicted target genes, DExD-box helicase 39B and MDM2, may be involved in the mechanisms of DM-ILD-MDA5 Ab(+).
other	34368147	hsa-mir-19a	Pneumonia, Mycoplasma	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
other	34368147	hsa-mir-2	PEHO syndrome	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
other	34368147	hsa-mir-19a	PEHO syndrome	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
other	34368147	hsa-mir-2	Pneumonia, Mycoplasma	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
other	34368147	hsa-mir-590	Pneumonia, Mycoplasma	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
other	34368147	hsa-mir-590	PEHO syndrome	5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology.
circulation_biomarker_diagnosis_ns	34368146	hsa-mir-451	Pancreatic Carcinoma	ADAM8-dependent co-variates, miR-451 and miR-720 were also diagnostic, as patients with PDAC had significantly higher serum levels of miR-451 and lower serum levels of miR-720 than healthy controls and reached high sensitivity and specificity (AUC = 0.93 and 1.00, respectively) to discriminate PDAC from healthy control.
circulation_biomarker_diagnosis_ns	34368146	hsa-mir-720	Pancreatic Carcinoma	ADAM8-dependent co-variates, miR-451 and miR-720 were also diagnostic, as patients with PDAC had significantly higher serum levels of miR-451 and lower serum levels of miR-720 than healthy controls and reached high sensitivity and specificity (AUC = 0.93 and 1.00, respectively) to discriminate PDAC from healthy control.
other	34368141	hsa-mir-29c	Adenocarcinoma of Lung	This research provides clinical references for LUAD immunotherapy and prognosis and interprets a potential genome instability-related ceRNA regulatory network in which LINC01224-miR5p/miR-29c-3p-CCNF-RRM2 and LINC01224-miR485-5p-PKMYT1-CDK1 axes were the most promising pathways.
other	34368141	hsa-mir-485	Adenocarcinoma of Lung	This research provides clinical references for LUAD immunotherapy and prognosis and interprets a potential genome instability-related ceRNA regulatory network in which LINC01224-miR5p/miR-29c-3p-CCNF-RRM2 and LINC01224-miR485-5p-PKMYT1-CDK1 axes were the most promising pathways.
target gene	34368128	hsa-mir-185	Lung Neoplasms	Inhibition of miR-185-3p Confers Erlotinib Resistance Through Upregulation of PFKL/MET in Lung Cancers.
lncRNA target	34368091	hsa-mir-34c	Acute Lung Injury	CONCLUSION: Our results indicate that BMSC-CM may alleviate LPS-induced ALI through miR-34c targeting MARCKS and regulate ENaC indirectly, which further explores the benefit of paracrine effects of bone marrow-derived MSCs on edematous ALI.
genetics_knock down_promote	34367901	hsa-mir-101	Osteosarcoma	Overexpressing miR
lncRNA target	34367463	hsa-mir-146a	Myocardial Reperfusion Injury	Taken together, the results suggest that miR-146a protects against myocardial ischaemia reperfusion injury by inhibiting NOX4 signalling.
circulation_biomarker_prognosis_up	34367281	hsa-mir-21	Pancreatic Carcinoma	RESULTS: Serum CA199 and miR-21 levels in the PC group were significantly higher than those in the benign lesion group and control group.
lncRNA target	34367236	hsa-mir-374a	Urinary Bladder Neoplasms	In conclusion, our results demonstrated that lncRNA KCNMB2-AS1 can promote the progression of bladder cancer through regulation of miR-374a-3p/S100A10.
genetics_knock down_promote	34367233	hsa-mir-637	Ovarian Neoplasms	Conclusion: Circ_0013958 knockdown impeded OC development through modulating the miR-637/PLXNB2 axis, highlighting a therapeutic target for OC.
other	34366343	hsa-mir-1909	Alzheimer Disease	3p levels decreased significantly in the aMCI group.
other	34366343	hsa-mir-22	Alzheimer Disease	3p levels decreased significantly in the aMCI group.
other	34366343	hsa-mir-134	Alzheimer Disease	3p levels decreased significantly in the aMCI group.
other	34366343	hsa-mir-1185-2	Alzheimer Disease	3p levels decreased significantly in the aMCI group.
circulation_biomarker_diagnosis_up	34366325	hsa-mir-182	Pleural Effusion, Malignant	CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE.
circulation_biomarker_diagnosis_up	34366325	hsa-mir-21	Pleural Effusion, Malignant	CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE.
circulation_biomarker_diagnosis_up	34366325	hsa-mir-29c	Pleural Effusion, Malignant	CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE.
transcription factor target	34366323	hsa-mir-101	Rectal Neoplasms	5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways.
transcription factor target	34366323	hsa-mir-17	Rectal Neoplasms	5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways.
transcription factor target	34366323	hsa-mir-145	Rectal Neoplasms	5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways.
transcription factor target	34366323	hsa-mir-221	Rectal Neoplasms	5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways.
circulation_biomarker_diagnosis_up	34366268	hsa-mir-142	Lichen Planus, Oral	3p was detected in the serum, saliva, and tissues samples from patients with OLP.
other	34366240	hsa-let-7c	Carcinoma, Hepatocellular	RESULTS: Expression levels of let-7c predict tumor relapse after RFA; we also investigated the same panel in a small cohort of HCC patients undergoing surgery, finding no statistically significance in predicting tumor relapse or survival.
other	34365931	hsa-mir-14669	Colorectal Neoplasms	OBJECTIVES: This study aimed to identify a novel miRNA-14669 that can reverse vincristine resistance and sensitize drug-resistant colorectal cancer cells. CONCLUSION: We identified a novel miRNA-14669 that may be associated with the chemotherapeutic resistance in CRC cells.
genetics_overexpression_suppress	34365889	hsa-mir-106a	Breast Neoplasms	Here, our results illustrate that VCAN-AS1 is overexpressed in BC tissues and cells, while miR-106a-5p was downregulated and negatively correlated with VCAN-AS1. In addition, high VCAN-AS1 expression and low miR-106a-5p expression were closely correlated with poor overall survival in BC patients.
genetics_overexpression_suppress	34365839	hsa-mir-15a	Stomach Neoplasms	In this project, we demonstrated significant overexpression of ONECUT2 and down-regulation of hsa-miR-15a-5p in gastric cancer via bioinformatics analysis and in vitro assays. Then, we separated CD133+/CD44+ MKN45 by flow cytometry and found that, compared with parental MKN45, CD133+/CD44+ MKN45 gastric cancer stem cells (GCSCs) had higher levels of ONECUT2 and lower levels of hsa-miR-15a-5p.
genetics_knock down_promote	34365722	hsa-mir-616	Stomach Neoplasms	CES4 knockdown promoted cell viability and inhibited apoptosis of drug-treated HGC-27 and MKN-7 cells by regulating miR
tissue_expression_ns	34364983	hsa-mir-144	Aortic Aneurysm, Abdominal	Anti-growth effect of miR3p and related genes was evaluated in a murine AAA model. MiR3p was highly expressed in AAA tissues. miR3p serves as a promoter for the apoptosis of SMCs, which contributes to the occurrence and progression of AAA.
genetics_knock down_suppress	34364880	hsa-mir-378	Myelodysplastic Syndromes	A model of aberrant myeloid maturation that mimics MDS was generated using a stable knockdown of miR3p.
other	34363931	hsa-mir-155	Liver Injury	CONCLUSIONS: These results indicated that miR-155 played an important role in TP-induced hepatotoxicity by regulating the Nrf2 signaling pathway.
genetics_overexpression_promote	34363308	hsa-mir-199b	Squamous Cell Carcinoma of Head and Neck	Overexpression of LINC01783 sponged miR-199b-5p in TSCC cell and elevated expression of LINC01783 inhibited miR-199b-5p expression.
other	34363272	hsa-mir-133	Myasthenia Gravis	Taken together, our study showed that upregulation of circ-FBL promoted myogenic proliferation in patients with MG by regulating miR-133/PAX7.
exosome	34362882	hsa-mir-101	Inflammation	Collectively, this study suggests that the HIF1alpha-dependent suppression of exosome miR101 from hypoxic tumor cells activates macrophages to induce inflammation in the tumor microenvironment.
other	34362591	hsa-mir-367	Uterine Cervical Neoplasms	CONCLUSIONS: The up-regulated FEZF1-AS1 could accelerate the malignant behaviors of CC cells by miR3p/SLC12A5 signal axis.
transcription factor target	34362486	hsa-mir-142	Acute Lymphocytic Leukemia, B-Cell	3p Targeting HOXA5 on Proliferation, Cycle Arrest and Apoptosis of Acute B Lymphocytic Leukemia Cells].
lncRNA target	34362467	hsa-mir-137	Hemangioma, Cavernous	CONCLUSION: TUG1 was closely associated with the progression of IH by regulating the miR-137/IGFBP5 axis, which might be a potential target for IH treatment.
lncRNA target	34362407	hsa-mir-335	Triple Negative Breast Neoplasms	5p, and SNHG8 promoted TNBC cell proliferation, migration and EMT process through regulating miR
genetics_knock down_promote	34362391	hsa-mir-381	Breast Neoplasms	3p inhibited breast cancer proliferation and invasion, whereas knockdown of miR
other	34362313	hsa-mir-20a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: In conclusion, we have reported a novel CASC18/miR-20a-3p/TGFB2 ceRNA axis in OLNM of TSCC.
genetics_GWAS	34362257	hsa-mir-99a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-mir-100	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-mir-18a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-let-7a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-let-7	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-mir-145	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34362257	hsa-mir-24	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_knock down_promote	34361070	hsa-mir-7	Thyroid Cancer, Papillary	5p knockdown results in the down-regulation of the iron storage gene expression such as ferritin, up-regulation of the ferroptosis marker ALOX12 gene expression, and increases of Liperfluo amount.
lncRNA target	34360981	hsa-mir-210	Polycystic Ovary Syndrome	MicroRNA-210 (miR-210), its target genes (SDHD and GPD1L), and HIF-1alpha-responsive genes (EDN2 and VEGFA) differed in GLCs from PCOS, compared with those of healthy women.
other	34360898	hsa-mir-129a	Dysentery	Our results have laid the foundation for in-depth study of the mechanism of miR-129a-3p resistance and its application in porcine epidemic diarrhea disease-resistance breeding.
genetics_overexpression_promote	34360898	hsa-mir-129a	Postoperative Nausea and Vomiting	Overexpression of miR-129a-3p can activate the caspase activation and recruitment domain 11 (CARD11) mediated NF-kappaB pathway, thus inhibiting PEDV replication.
other	34360895	hsa-mir-1	Diabetes Mellitus, Type 2	RESULTS: LncRNA-RP11-773H22.4, together with RET, IGF1R and mTOR mRNAs, showed significant upregulation in T2DM compared with matched controls, while miRNA (i.e., miR-3163 and miR-1) and mRNA (i.e., GLUT4 and AKT2) expression displayed marked downregulation in diabetic samples.
other	34360895	hsa-mir-3163	Diabetes Mellitus, Type 2	RESULTS: LncRNA-RP11-773H22.4, together with RET, IGF1R and mTOR mRNAs, showed significant upregulation in T2DM compared with matched controls, while miRNA (i.e., miR-3163 and miR-1) and mRNA (i.e., GLUT4 and AKT2) expression displayed marked downregulation in diabetic samples.
genetics_overexpression_promote	34360757	hsa-mir-146b	Thyroid Neoplasms	In thyroid cancer, miR-146b-5p is the most overexpressed miRNA associated with tumor aggressiveness and progression, while the antisense blocking of miR-146b-5p results in anti-tumoral effect.
other	34360711	hsa-mir-762	Brain Ischemia	Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury.
lncRNA target	34360679	hsa-mir-20a	Carcinoma, Renal Cell	Identification of miR-20a-5p as Robust Normalizer for Urine microRNA Studies in Renal Cell Carcinoma and a Profile of Dysregulated microRNAs.
other	34360304	hsa-mir-320d	Chronic Periodontitis	5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis.
other	34360304	hsa-mir-28	Chronic Periodontitis	5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis.
other	34360304	hsa-mir-99a	Chronic Periodontitis	5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis.
other	34360304	hsa-mir-5571	Chronic Periodontitis	5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis.
other	34360304	hsa-let-7f	Chronic Periodontitis	5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis.
genetics_knock down_promote	34360007	hsa-mir-126	Cartilage Degradation	In sum, the loss of PGC1alpha in chondrocytes due to upregulation of miR5p during OA pathogenesis resulted in the activation of PRKN-independent mitophagy through the upregulation of BNIP3 and stimulated cartilage degradation and apoptotic death of chondrocytes.
other	34360002	hsa-mir-214	Muscular Dystrophy, Duchenne	3p is a key activator of FAP fibrogenesis by modulating the FGF2/FGFR1/TGFbeta axis, opening new avenues for the treatment of DMD.
other	34359879	hsa-mir-132	Brain Ischemia	The effects of miRNA-132/212 gene-deletion on hippocampal synaptic transmission and levels of cholinergic-signaling elements suggest the existence of a miRNA-132/212-dependent adaptive mechanism safeguarding the functional integrity of synaptic functions in the acute phase of cerebral ischemia.
circulation_biomarker_diagnosis_ns	34359778	hsa-mir-17	Multiple Myeloma	5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without.
circulation_biomarker_prognosis_ns	34359778	hsa-mir-335	Multiple Myeloma	5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without.
circulation_biomarker_prognosis_ns	34359778	hsa-let-7b	Multiple Myeloma	5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without.
circulation_biomarker_diagnosis_ns	34359778	hsa-mir-143	Multiple Myeloma	5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without.
circulation_biomarker_diagnosis_ns	34359778	hsa-mir-214	Multiple Myeloma	5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without.
other	34359739	hsa-mir-655	Breast Neoplasms	We reported that two microRNAs, miR526b and miR655, are oncogenic in breast cancer (BC).
circulation_biomarker_diagnosis_ns	34359739	hsa-mir-526b	Breast Neoplasms	Additionally, with a case-control cohort study, we identified that high expression of pri-miR526b in the blood is also a risk factor associated with breast cancer (OR = 4.3, CI = 1.39-13.34, p = 0.01).
other	34358482	hsa-mir-21	Breast Neoplasms	The expression of SPTBN1, EMT-related genes, and miRNA21 in breast cancer cells and tissues were assessed by quantitative real-time polymerase chain reaction (qPCR) and Western blot.
other	34358374	hsa-mir-6868	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: H3K27ac-induced FOXC2-AS1 exhibits carcinogenic property in TSCC by the miR5p/E2F3 axis.
circulation_biomarker_diagnosis_ns	34357821	hsa-mir-765	Diabetes Mellitus, Type 2	By qRT-PCR and western blotting, miR-765 with high expression and PDX1 with low expression were observed in blood samples from T2DM patients and the T2DM cell model.
circulation_biomarker_diagnosis_ns	34357569	hsa-mir-192	Atherosclerosis	The expression level of serum miR
other	34357552	hsa-mir-149	Parkinson Disease	5p has decreased, followed by PD induction in rats.
lncRNA target	34357507	hsa-mir-582	Colorectal Neoplasms	5p and its target gene TNKS2 could be novel biomarkers for metastatic disease prediction, overall prognosis evaluation, as well as potential therapeutic target for colorectal cancer patients.
genetics_knock down_promote	34357490	hsa-mir-195	Glioma	CONCLUSION: Knockdown of Circ_CLIP2 suppresses glioma progression by targeting miR
circulation_biomarker_diagnosis_up	34357372	hsa-mir-222	Colorectal Neoplasms	Here, we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer (CRC), and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148, respectively. These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222.
circulation_biomarker_diagnosis_up	34357372	hsa-mir-221	Colorectal Neoplasms	Here, we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer (CRC), and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148, respectively. These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222.
other	34356909	hsa-mir-6821	Pancreatic Carcinoma	Six miRNAs were independently correlated with early PDAC, and among these, hsa-miR5p was associated with the best ROC curve area in distinguishing controls from early PDAC.
other	34356894	hsa-mir-181b	Pulmonary Disease, Chronic Obstructive	Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD.
other	34356894	hsa-mir-181b	Lung Neoplasms	Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD.
other	34356894	hsa-mir-23c	Pulmonary Disease, Chronic Obstructive	Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD.
other	34356894	hsa-mir-23c	Lung Neoplasms	Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD.
other	34356879	hsa-mir-142a	Acute Kidney Injury	3p, in the injured kidneys at various time points.
other	34356879	hsa-mir-146a	Acute Kidney Injury	3p, in the injured kidneys at various time points.
other	34356879	hsa-mir-214	Acute Kidney Injury	3p, in the injured kidneys at various time points.
other	34356879	hsa-mir-199a	Acute Kidney Injury	3p, in the injured kidneys at various time points.
other	34356879	hsa-mir-223	Acute Kidney Injury	3p, in the injured kidneys at various time points.
circulation_biomarker_diagnosis_down	34356875	hsa-mir-23b	Carcinoma, Hepatocellular	miR-23b-3p was further measured by ddPCR in 37 healthy individuals and 25 untreated HCC patients. The amount of miR-23b-3p in the plasma of untreated HCC patients was significantly downregulated if compared to healthy individuals.
other	34356850	hsa-mir-424	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
other	34356850	hsa-mir-339	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
other	34356850	hsa-mir-369a	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
other	34356850	hsa-mir-100	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
other	34356850	hsa-mir-199a	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
other	34356850	hsa-mir-15a	Ischemic Stroke	Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs.
lncRNA target	34356844	hsa-mir-138	Glioblastoma	Previously, we found miR-138 as one of tumor suppressive miRNAs that were significantly down-regulated in GBM.
other	34356708	hsa-mir-21	Lung Neoplasms	Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer.
other	34356708	hsa-mir-155	Lung Neoplasms	Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer.
genetics_overexpression_promote	34356658	hsa-mir-1290	Squamous Cell Carcinoma of Head and Neck	We have shown previously that the overexpressed miR-1290 influences MAF protein levels in LSCC (laryngeal squamous cell carcinoma) cell lines.
other	34356656	hsa-mir-545	Kidney Diseases	These findings provided new perceptions of the unique regulation of the miR3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
transcription factor target	34356508	hsa-mir-181	Liver Diseases	These results indicate that CVS results in liver damage and induces hepatic Fe(II) accumulation, which is closely associated with the up-regulation of ZIP14 expression via the miR-181 family pathway.
lncRNA target	34356326	hsa-mir-122	Carcinoma, Hepatocellular	Furthermore, microRNA antisense-targeted sites for miR122, known to be widely expressed in normal hepatocytes while downregulated in hepatocellular carcinoma, were added to specifically limit cytotoxicity in HCC cells, thereby limiting the off-target effects.
other	34356073	hsa-mir-29a	Fabry   Nephropathy	However, we found increased expression of miR-29a-3p and miR-200a-3p in uEVs isolated from chronological samples of patients with Fabry nephropathy.
other	34356073	hsa-mir-200a	Fabry   Nephropathy	However, we found increased expression of miR-29a-3p and miR-200a-3p in uEVs isolated from chronological samples of patients with Fabry nephropathy.
lncRNA target	34355838	hsa-mir-577	Myocardial Infarction, Acute	Overall, NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via the miR-577/COBLL1 axis.
circulation_biomarker_diagnosis_ns	34355706	hsa-mir-26b	Colonic Neoplasms	Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b.
lncRNA target	34355586	hsa-mir-188	Carcinoma, Hepatocellular	3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.
lncRNA target	34355586	hsa-mir-133b	Carcinoma, Hepatocellular	3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.
circulation_biomarker_diagnosis_down	34355355	hsa-mir-129	Hypoxia-Ischemia, Brain	5p was revealed to be downregulated in the serum of patients with IBI.
circulation_biomarker_diagnosis_ns	34355070	hsa-mir-148a	Carcinoma, Hepatocellular	RESULTS: Patients with HCC had lower plasma miRNA 148a-3p, higher serum TGF-beta1, and higher FIB-4 levels than patients with cirrhosis and controls.
other	34355069	hsa-mir-182	Stomach Neoplasms	5p were down regulated in gastric cancer patients in Group I more than Groups II and III (P < 0.001).
other	34355036	hsa-mir-191	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-486	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-378c	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-2904	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-2478	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-378	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-431	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
other	34355036	hsa-mir-2285n	Infertility	We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel.
lncRNA target	34354942	hsa-mir-766	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Further, CDKN1A was proved to be the target gene of miR
transcription factor target	34354862	hsa-mir-196b	Esophageal Squamous Cell Carcinoma	Taken together, these findings suggest that miR-196b is a strong candidate molecular target for EC treatment.
transcription factor target	34354409	hsa-mir-186	Osteoarthritis, Knee	In light of this evidence, we propose that molecular therapeutic interventions targeting miR-186 activation might attenuate osteoarthritic cartilage degeneration.
target gene	34354393	hsa-mir-485	Ovarian Neoplasms	E74-like factor 3 suppresses microRNA-485-5p transcription to trigger growth and metastasis of ovarian cancer cells with the involvement of CLDN4/Wnt/β-catenin axis.
lncRNA target	34354391	hsa-mir-216a	Asthma	LncRNA MALAT1 and microRNA-216a are involved in the regulation of AMSCs respectively, but there is no research to prove that they can regulate airway remodeling of asthma through mutual combination.
circulation_biomarker_diagnosis_ns	34354365	hsa-mir-486	Sepsis	Kaplan-Meier estimator and Cox regression hazards analysis of the predictive significance of serum miR
lncRNA target	34354043	hsa-mir-4793	Stomach Neoplasms	3p as a ceRNA to eliminate the negative regulation of FOXO1, therefore suppressing GC proliferation.
lncRNA target	34354038	hsa-mir-204	Alzheimer Disease	The overall results demonstrated that inhibition of miR-204 prevents axonal dystrophy by blocking BRUCE interaction with STX17, which unraveled potential novel therapeutic targets for delaying AD.
lncRNA target	34353856	hsa-mir-766	Histiocytic Sarcoma	Moreover, miR5p suppressed expression of a BRD4-NUT fusion protein that drives NUT midline carcinoma.
genetics_overexpression_suppress	34353082	hsa-mir-449	Arthritis, Rheumatoid	HDAC1 overexpression reversed the biological effects of miR-449 on RASFs (P<0.001).
lncRNA target	34352998	hsa-mir-4487	Carcinoma, Non-Small-Cell Lung	MATERIALS AND METHODS: To examine the physiological roles of miR-4487 and ubiquitin-specific peptidase 37 (USP37) in gefitinib-mediated EGFR degradation in NSCLC cells, multiple NSCLC cell lines were applied. CONCLUSION: These data suggest that miR-4487 is a potential target for treating NSCLC, and miR-4487/USP37-regulated EGFR degradation is a determinant for developing gefitinib resistance.
genetics_overexpression_promote	34352938	hsa-mir-451a	Breast Neoplasms	Overexpression of miR-451a repressed BC cells proliferation, migration and invasion.
lncRNA target	34352791	hsa-mir-101	Lung Neoplasms	3p could be a potential target of XIST through direct binding with it as a competing endogenous RNA, which was further validated from lung tumor tissues and cell lines by luciferase assay.
transcription factor target	34352784	hsa-mir-182	Diabetic Retinopathy	CONCLUSION: APS alleviated mitochondrial damage and apoptosis induced by metabolic memory by regulating the miR-182/Bcl-2 axis, which might serve as a new strategy for the treatment of diabetic retinopathy.
other	34352236	hsa-mir-29a	Pneumonia, Mycoplasma	RESULTS: TUG1 and VEGFA levels were downregulated, and levels of miR-29a-3p, sFLT1 and sENG were increased in PE patients.
other	34352040	hsa-mir-20b	Ovarian Neoplasms	3p, CA-125 and HE4).
other	34352040	hsa-mir-141	Ovarian Neoplasms	3p, CA-125 and HE4).
genetics_overexpression_promote	34351868	hsa-mir-106b	Adenocarcinoma of Lung	Moreover, inhibition of miR-106b-5p significantly decreased in vitro proliferation, migration, and invasion by LUAD cells, whereas miR-106b-5p overexpression reversed those effects.
genetics_overexpression_promote	34351577	hsa-mir-299	Breast Neoplasms	However, inhibition of miR-299 or overexpression of BACH1 could reverse the inhibitory effects of sh-SNHG5 on cell proliferation and glycolysis in BC.
circulation_biomarker_diagnosis_up	34351574	hsa-mir-197	Mucocutaneous Lymph Node Syndrome	3p and its target, TIMP3, are dramatically variational in KD serum and HCAECs cultured with KD serum.
lncRNA target	34351558	hsa-mir-1298	Myocardial Reperfusion Injury	This study aims to investigate the function and specific mechanism of miR-1298 in myocardial ischemia/reperfusion (IR) injury. MiR-1298 participated in myocardial I/R injury by targeting the PP2A/AMPK/GSK3beta signaling pathway, suggesting that miR-1298 might be a potential therapeutic target for myocardial I/R injury.
circulation_biomarker_diagnosis_ns	34350970	hsa-mir-150	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	OBJECTIVE: To assess the circulating micro-RNA-150 (miR-150) expression in patients with chronic myeloid leukemia (CML) in relation to imatinib response.
exosome	34350954	hsa-mir-21	Atherosclerosis	In conclusion, MSC-derived exosomes containing miR-21a-5p promote macrophage polarization and reduce macrophage infiltration by targeting KLF6 and ERK1/2 signaling pathways, thereby attenuating the development of AS.
other	34350836	hsa-mir-7	Intervertebral Disc Degeneration	5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3.
other	34350836	hsa-mir-574	Intervertebral Disc Degeneration	5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3.
other	34350836	hsa-let-7e	Intervertebral Disc Degeneration	5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3.
other	34350834	hsa-mir-100	Atrial Fibrillation	Connectivity Map and Comparative Toxicogenomics Database searches predicted dexamethasone may treat AF by reversing the expression of MIR100HG; artemisinin may reverse the expression of hub DEGs.
genetics_knock down_suppress	34350748	hsa-mir-744	Reperfusion Injury, Cerebral Ischemia	LINC00665 knockdown was validated to project CI/R injury by sponging miR5p expression.
lncRNA target	34350720	hsa-mir-34a	Osteoporosis	Taken together, our study revealed the key role of the lncRNA TUG1/miR-34a/FGFR1 axis in FSS-regulated osteoblast proliferation and apoptosis and may provide potential therapeutic targets for osteoporosis.
genetics_GWAS	34350711	hsa-let-7d	Pre-Eclampsia	Such an epigenetic network of let-7d, KDM3A and ENO2 in the pathogenesis of PE might provide novel insight into targeted therapy against this disorder.
lncRNA target	34350661	hsa-mir-4455	Uterine Cervical Neoplasms	CONCLUSIONS: Inhibition of UNC5B-AS1/miR-4455/RSPO4 reduces CC growth both in vitro and in vivo, furnishing new insights into molecular studies on UNC5B-AS1 with respect to CC development.
other	34350290	hsa-mir-124	Osteosarcoma	By using the KM Plotter software, miRNA-124 and ARHGEF3 were obviously associated with the overall survival of patients with osteosarcoma.
target gene	34350182	hsa-mir-214	Uterine Cervical Neoplasms	SPINT1-AS1 Drives Cervical Cancer Progression via Repressing miR-214 Biogenesis.
other	34350110	hsa-mir-145	Breast Neoplasms	PCDHB17P/miR-145-3p/MELK/NF-κB Feedback Loop Promotes Metastasis and Angiogenesis of Breast Cancer.
exosome	34349799	hsa-mir-665	Lung Neoplasms	Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL.
lncRNA target	34349786	hsa-mir-16-2	Pneumoconiosis	We found miR2-3p may used as biomarker for REP, because it is closely related to the occurrence and prognosis of REP through inflammatory reaction and in lung squamous cell carcinoma, its expression levels were positively correlated with the overall survival rate of patients.
genetics_overexpression_suppress	34349660	hsa-mir-192	Diabetic Nephropathies	5p overexpression-induced fibrosis production and autophagy limitation.
other	34349559	hsa-mir-4284	Carcinoma, Non-Small-Cell Lung	miR-4284 Promotes Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells and is Associated with Postoperative Prognosis.
other	34349427	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	The comparative Ct method was used to analyze the differences in subsite specific expression of miR-21 in OSCC cases.
target gene	34349351	hsa-mir-17	Uterine Cervical Neoplasms	miR-17-5p accelerates cervical cancer cells migration and invasion via the TIMP2/MMPs signaling cascade.
lncRNA target	34349349	hsa-mir-182	Carcinoma, Renal Cell	Our experimental data further showed that miR-182 could be delivered by MSC-Exo in ccRCC, which targeted vascular endothelial growth factor A (VEGFA), as dual-luciferase reporter assays validated. In conclusion, miR-182 contained in MSC-Exo promoted immune response of T cells by suppressing VEGFA expression, thus alleviating ccRCC development.
target gene	34349348	hsa-mir-185	Uterine Cervical Neoplasms	miR-185-3p targets Annexin-A8 to inhibit proliferation in cervical cancer cells.
genetics_knock down_promote	34349347	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	3p could abate the effects of circ_0014130 knockdown in DTX-resistant NSCLC cells in vitro, whereas its overexpression exerted similar effects of circ_0014130 knockdown.
target gene	34349344	hsa-mir-103a	Liver Neoplasms	Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis.
lncRNA target	34348712	hsa-mir-212	Carcinoma, Hepatocellular	Further studies revealed that circFAM13B, a sponge of miR-212, is involved in the regulation of E2F5 gene expression by competitively binding to miR-212, inhibits the activation of the P53 signalling pathway, and promotes the proliferation of HCC cells. CONCLUSIONS: Our findings revealed the mechanism underlying the regulatory role played by circFAM13B, miR-212 and E2F5 in HCC.
circulation_biomarker_diagnosis_ns	34348591	hsa-mir-155	Acquired Immunodeficiency Syndrome	T cell immune activation was detected by the expression of CD38 via flow cytometry.Results: The levels of miR-155 in the total peripheral blood mononuclear cells, CD4+, and CD8+ T cells from HIV-1 patients were increased (p < 0.01). MiR-155 level was positively related to immune activation of T cells.Conclusion: Our findings suggest that miR-155 levels in circulating T cells of HIV-1 patients are increased and associated with T cell activation.
lncRNA target	34348465	hsa-mir-520a	Osteosarcoma	miR-520a-3p targeted GAB1 to repress OS cell proliferation and metastasis.
genetics_knock down_suppress	34348296	hsa-mir-148a	Epilepsy, Temporal Lobe	miR-148a-3p is overexpressed and associated with seizure frequency and FS history and serves as a novel diagnostic biomarker in TLE.
genetics_overexpression_promote	34348265	hsa-mir-345	Glioma	When expression of hsa_circ_0073237 and miR-345 was inhibited simultaneously, cell viability, apoptosis, and invasion did not change significantly; however, after transfection with HDGF overexpression vector, the effects of hsa_circ_0073237 siRNA and miR-345 on glioma cell viability, apoptosis, and invasion were obviously reversed.
genetics_overexpression_promote	34347980	hsa-mir-18a	Endometrial Neoplasms	In addition, rescue experiments revealed that the oncogenic effect of miR-18a-5p on EC cells was inhibited by THBD overexpression.
genetics_knock down_suppress	34347977	hsa-mir-543	Small Cell Lung Carcinoma	It also showed that knockdown of miR-543 can inhibit the proliferation and migration of SCLC cells, induce apoptosis, and increase the level of apoptosis-related proteins.
lncRNA target	34346845	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	5p/E2F3 axis, promotes NSCLC progression, which is a promising therapeutic target for NSCLC.
lncRNA target	34346538	hsa-mir-34a	Polycystic Ovary Syndrome	Under such context, the present study aimed to investigate the mechanism underlying the involvement of ox-HDL in PCOS in relation to the p65/micro-RNA-34a (miR-34a)/FOS axis. In conclusion, our findings suggested that ox-HDL promoted the activation of p65 and transcription of miR-34a, which stimulated apoptosis of GCs and inhibited expression of FOS, resulting in the overall acceleration of PCOS development.
genetics_knock down_promote	34346534	hsa-mir-223	Respiratory Distress Syndrome	Finally, we found that OIP5-AS1 knockdown and miR-223 overexpression could both alleviate LPS-induced ALI/ARDS in vivo.
genetics_knock down_promote	34346534	hsa-mir-223	Acute Lung Injury	Finally, we found that OIP5-AS1 knockdown and miR-223 overexpression could both alleviate LPS-induced ALI/ARDS in vivo.
other	34346250	hsa-mir-29b	Penile Induration	CONCLUSION: Although our study has a small sample, we showed for the first time an evidence that the downregulation of miR-29b is associated with PD.
other	34346162	hsa-mir-150	Osteosarcoma	Thus, these findings demonstrate that EGR1/ LINC00857/miR5p/c-Myc axis plays a key role in promoting anticancer effects of Scutellarin and Scutellarin might have potential clinical implication in osteosarcoma clinical treatment.
genetics_knock down_promote	34346032	hsa-mir-370	Thyroid Cancer, Papillary	Taken together, CircUBAP2 knockdown impeded the proliferation and invasion and induced apoptosis in TC cells via sponging miR
genetics_knock down_promote	34346000	hsa-mir-132	Acute Lung Injury	LncRNA XIST knockdown alleviates LPS-induced acute lung injury by inactivation of XIST/miR-132-3p/MAPK14 pathway : XIST promotes ALI via miR-132-3p/MAPK14 axis.
target gene	34345298	hsa-mir-654	Thyroid Neoplasms	Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p.
genetics_knock down_suppress	34345289	hsa-mir-125b	Squamous Cell Carcinoma of Head and Neck	miR-125b-5p expression was downregulated in LSCC tissues and cells as determined using RT-qPCR. In conclusion, knockdown of circ_0001883 inhibited cell migration, invasion and EMT of LSCC by sponging miR-125b-5p.
genetics_knock down_promote	34345283	hsa-mir-758	Osteoarthritis, Knee	3p affects the proliferation of synovial cells and the expression of relevant proteins in these cells, thus promoting the occurrence and development of KOA.
lncRNA target	34345281	hsa-mir-200c	Asthma	Inhibition of miR-200c-3p reversed the suppression of asthmatic inflammation by MIM.
lncRNA target	34345270	hsa-mir-451a	Granulomatosis with Polyangiitis	KGN cells were transfected with miR-451a inhibitor or inhibitor control sequences for 6 h and treated with 10 microg/ml propofol for an additional 48 h.
lncRNA target	34345270	hsa-mir-451a	Polycystic Ovary Syndrome	However, the diagnostic applications of miR-451a in PCOS remain unknown. In addition, the data indicated that miR-451a may be used as an effective therapeutic target for PCOS treatment.
other	34345264	hsa-mir-16	Acute Lung Injury	Overall, these aforementioned findings suggest that miR-16 may serve a protective role against LPS-mediated inflammatory responses in NHBE cells by regulating TLR4, where this mechanism may be considered to be a novel approach for treating ALI in the future.
lncRNA target	34345220	hsa-mir-216	Breast Neoplasms	Taken together, our findings indicated that miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC.
lncRNA target	34345208	hsa-mir-21	Spinal Cord Injuries	Collectively, our findings demonstrate that targeting miR-21a-5p represents a prospective therapy for promoting the recovery of TSCI.
lncRNA target	34345208	hsa-mir-21	Inflammation	Collectively, our findings demonstrate that targeting miR-21a-5p represents a prospective therapy for promoting the recovery of TSCI.
lncRNA target	34345178	hsa-mir-221	Osteitis	Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis.
lncRNA target	34345178	hsa-mir-21	Osteitis	Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis.
lncRNA target	34345178	hsa-mir-144	Osteitis	Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis.
circulation_biomarker_diagnosis_ns	34344968	hsa-mir-223	Substance-Related Disorders	We revealed that the circulating levels of IL-18, NETs, and miR-223 were significantly higher in active AOSD patients, compared with inactive AOSD patients or healthy controls (P < 0.005).
transcription factor target	34344968	hsa-mir-223	Hereditary Autoinflammatory Diseases	MiR-223, mROS inhibitors, and calcium channel blockers are the potential therapeutics for autoinflammatory diseases such as AOSD.
transcription factor target	34344912	hsa-mir-4057	Thinness	Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR1-5p) associated with underweight status in male placentas.
transcription factor target	34344912	hsa-mir-128-1	Thinness	Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR1-5p) associated with underweight status in male placentas.
exosome	34344478	hsa-mir-21	Cicatrix	CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing.
other	34344478	hsa-mir-21	Huntington Disease	Using miRNA mimics, we found that miR5p and miR-125b-5p were critical for anti-myofibroblast differentiation in the TGF-beta1-induced HDF.
exosome	34344478	hsa-mir-125b	Wounds and Injuries	CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing.
other	34344478	hsa-mir-125b	Huntington Disease	Using miRNA mimics, we found that miR5p and miR-125b-5p were critical for anti-myofibroblast differentiation in the TGF-beta1-induced HDF.
exosome	34344478	hsa-mir-125b	Cicatrix	CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing.
exosome	34344478	hsa-mir-21	Wounds and Injuries	CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing.
circulation_biomarker_diagnosis_ns	34344352	hsa-mir-29a	Obesity	CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g.
circulation_biomarker_diagnosis_ns	34344352	hsa-mir-122	Obesity	CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g.
circulation_biomarker_diagnosis_ns	34344352	hsa-mir-122	Diabetes Mellitus, Type 2	CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g.
circulation_biomarker_diagnosis_ns	34344352	hsa-mir-29a	Diabetes Mellitus, Type 2	CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g.
other	34343969	hsa-mir-371a	Testicular Germ Cell Tumor	This research identified that miR-371a-3p has a high diagnostic value for TGCTs, except teratoma.
transcription factor target	34343834	hsa-mir-96	Osteosarcoma	5p may function as an effective target in OS treatment.
circulation_biomarker_diagnosis_up	34343725	hsa-mir-19b	COVID-19	These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV
circulation_biomarker_diagnosis_up	34343725	hsa-mir-92a	COVID-19	These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV
circulation_biomarker_diagnosis_up	34343725	hsa-mir-19a	COVID-19	These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV
circulation_biomarker_diagnosis_ns	34343125	hsa-mir-215	Carcinoma, Hepatocellular	METHODOLOGY The gene expression of mature miRNA -21 and miRNA -215 in serum was analysed retrospectively using singleplex TaqMan two-step stem-loop quantitative real-time reverse-transcription PCR in 40 patients with HCC, 40 with chronic hepatitis C virus (HCV) with cirrhosis and 40 apparently healthy controls.
circulation_biomarker_diagnosis_down	34343125	hsa-mir-21	Carcinoma, Hepatocellular	METHODOLOGY The gene expression of mature miRNA -21 and miRNA -215 in serum was analysed retrospectively using singleplex TaqMan two-step stem-loop quantitative real-time reverse-transcription PCR in 40 patients with HCC, 40 with chronic hepatitis C virus (HCV) with cirrhosis and 40 apparently healthy controls.
other	34343008	hsa-mir-205	Nasopharyngeal Neoplasms	Since microRNA-205 (miRNA-205) is a predictive biomarker for antiradiation of nasopharyngeal carcinoma (NPC), quantitative detection of miRNA-205 is important for developing personalized strategies for the treatment of NPC. This method has great clinical application potential in the determination of miRNA-205, a biomarker for radiation-resistant NPC.
other	34342761	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis.
other	34342761	hsa-mir-211	Squamous Cell Carcinoma of Head and Neck	MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis.
other	34342761	hsa-mir-134	Squamous Cell Carcinoma of Head and Neck	MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis.
other	34342761	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	CLINICAL RELEVANCE: This conventional and convenient sampling tool, when coupled with an assessment of miR-31 expression, would seem to be an adjuvant approach to the diagnosis of OPMD and OSCC.
other	34342761	hsa-mir-146a	Squamous Cell Carcinoma of Head and Neck	MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis.
genetics_GWAS	34342374	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	The epigenetic signaling pathway of LINC00852/hsa-miR
transcription factor target	34341761	hsa-mir-4451	Dementia, Vascular	We also found that miR-4451 regulates the PI16 expression, which may be a key target and biomarker for hernia pathogenesis and dementia crosstalk.
transcription factor target	34341761	hsa-mir-4451	Hernia	We also found that miR-4451 regulates the PI16 expression, which may be a key target and biomarker for hernia pathogenesis and dementia crosstalk.
genetics_GWAS	34341435	hsa-mir-451a	Cardiovascular Diseases	5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.
genetics_GWAS	34341435	hsa-mir-451	Cardiovascular Diseases	5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.
genetics_GWAS	34341435	hsa-mir-451	Arthritis, Rheumatoid	5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.
genetics_GWAS	34341435	hsa-mir-451a	Arthritis, Rheumatoid	5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.
other	34341387	hsa-mir-371	Testicular Neoplasms	Especially for the seminomas CS1, the high sensitivity of miR371 in detecting TGCC cells may have clinical implications.
other	34341387	hsa-mir-371a	Testicular Neoplasms	Especially for the seminomas CS1, the high sensitivity of miR371 in detecting TGCC cells may have clinical implications.
lncRNA target	34341185	hsa-mir-361	Carcinoma, Hepatocellular	5p attenuated the influence of lncRNA SBF2-AS1 downregulation on the viability, proliferation, and migration capability of HCC cells.
transcription factor target	34341171	hsa-mir-21	Leishmaniasis, Visceral	miR-21 could therefore be used as a potential target for developing host-directed treatment for VL.
transcription factor target	34341171	hsa-mir-21	Leishmaniasis	miR-21 could therefore be used as a potential target for developing host-directed treatment for VL.
lncRNA target	34340705	hsa-mir-138-1	Carcinoma, Hepatocellular	1-3p and PAK5 and the molecular mechanisms of PAK5-mediated sorafenib resistance in HCC, which provided a potential therapeutic target in advanced HCC patients.
exosome	34340698	hsa-mir-144	Fractures, Bone	CONCLUSIONS: The results demonstrated an important role of exosomal miR5p in bone regeneration, offering insight into developing new strategy for the improvement of fracture healing in patients with diabetes mellitus.
exosome	34340698	hsa-mir-144	Diabetes Mellitus, Type 2	CONCLUSIONS: The results demonstrated an important role of exosomal miR5p in bone regeneration, offering insight into developing new strategy for the improvement of fracture healing in patients with diabetes mellitus.
circulation_biomarker_prognosis_ns	34340677	hsa-mir-211	Atherosclerosis	CONCLUSION: Serum miR
lncRNA target	34340571	hsa-mir-34b	Cardiomyopathies	ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells via the miR-34b-5p/SIRT1 axis, providing novel potential therapeutic targets for SIC.
lncRNA target	34340571	hsa-mir-34b	Sepsis	ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells via the miR-34b-5p/SIRT1 axis, providing novel potential therapeutic targets for SIC.
lncRNA target	34340259	hsa-mir-506	Carcinoma, Hepatocellular	CONCLUSION: Hsa_circ_0016788 facilitates the development of HCC through increasing PARP14 expression by regulating miR
other	34339965	hsa-mir-423	Spinal Cord Injuries	5p expression was decreased significantly after SCI in vivo and in vitro.
lncRNA target	34339961	hsa-mir-132	Acute Kidney Injury	Therefore, targeting miR
transcription factor target	34339855	hsa-mir-182	Colorectal Neoplasms	5p mediated Tiam1/Rac1/p38 MAPK signaling pathway, implying potential novel therapeutic targets for CRC patients.
circulation_biomarker_diagnosis_ns	34339758	hsa-mir-663	Pulmonary Arterial Hypertension	In contrast, circulating level of miR-663 dramatically reduced in PAH patients.
lncRNA target	34339707	hsa-mir-15a	Myocardial Infarction, Acute	Mechanistically, silencing transcription factor early growth response-1 (Egr-1) inhibited the level of miR-15a-5p, increased the protein expression of GPX4, accompanied by reduced ferroptosis and alleviated myocardial injury.
transcription factor target	34339487	hsa-mir-219	Breast Neoplasms	5p suppressed EMT and cell migration and invasion in breast cancer cells.
target gene	34339285	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p.
genetics_overexpression_suppress	34338998	hsa-mir-96	Adenocarcinoma of Lung	5p was overexpressed, which fostered LUAD cell proliferation, migration, and invasion.
genetics_overexpression_suppress	34338995	hsa-mir-195	Ovarian Neoplasms	In addition, overexpression of miR
genetics_knock down_promote	34338972	hsa-mir-122	Ischemic Stroke	Knockdown of Gm11974 attenuated neuronal injury in ischaemic stroke by regulating miR
genetics_knock down_suppress	34338955	hsa-mir-142	Acute Lung Injury	MIR3142HG knockdown protected against ALI induced by LPS through alleviating the apoptosis and inflammation of HPMECs.
genetics_knock down_promote	34338434	hsa-mir-206	Femur Head Necrosis	Knockdown of HIF-1 reversed the recovery effect of miR-206 inhibitor on SONFH cell model.
other	34338363	hsa-mir-4329	Myocardial Infarction, Acute	The expression of miR6718 and miR-4329 in patients with myocardial infarction was significantly lower than that in normal controls.
other	34338363	hsa-mir-6718	Myocardial Infarction, Acute	The expression of miR6718 and miR-4329 in patients with myocardial infarction was significantly lower than that in normal controls.
circulation_biomarker_diagnosis_up	34338285	hsa-mir-206	facioscapulohumeral muscular dystrophy 1	5p and miR-206 as new potential regulators of muscle pathology and miR-206 as a potential circulating biomarker for FSHD.
lncRNA target	34338153	hsa-mir-409	Pancreatic Carcinoma	miR-409 is a tumor suppressor of PC, the clinical significance of miR-409 in pancreatic cancer and related tumor cell function was clarified.
lncRNA target	34338152	hsa-mir-200a	Schistosomiasis	Our study demonstrated that upregulation of miR-200a might contribute to inhibiting schistosomiasis liver fibrosis.
lncRNA target	34338152	hsa-mir-200a	Liver Cirrhosis	Our study demonstrated that upregulation of miR-200a might contribute to inhibiting schistosomiasis liver fibrosis.
lncRNA target	34338146	hsa-mir-101	Prostatic Neoplasms	3P suppressed PCA progression via aiming for CUL4B, which may offer the new molecular target for PCA clinical treatment.
transcription factor target	34338136	hsa-mir-216b	Endometrial Neoplasms	Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR.
transcription factor target	34338136	hsa-mir-940	Endometrial Neoplasms	Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR.
transcription factor target	34338136	hsa-mir-1301	Endometrial Neoplasms	Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR.
transcription factor target	34338136	hsa-mir-363	Endometrial Neoplasms	Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR.
lncRNA target	34338087	hsa-mir-766	Norrie disease	The differentially expression of miR-766 and VCAM1 in DN patients was reversed by actoeside. CONCLUSIONS: Actoeside promoted the growth and repressed the apoptosis and inflammation of HK-2 cells via miR-766/VCAM1/NF-kappaB signalling pathway, affording a promising idea for the treatment of DN.
other	34337881	hsa-mir-210	Ischemic Stroke	At the end of the seven-day treatment, the area of cerebral infarction, the expression changes of miRNA-210 and ephrin A3 were determined.
genetics_overexpression_promote	34337864	hsa-mir-15a	Carcinoma, Renal Cell	In addition, overexpression of BTG2 could reverse the promotive effects of miR-15a on ccRCC.
genetics_knock down_promote	34337862	hsa-mir-125b	Stomach Neoplasms	Loss-of-function assays showed that miR-125b-5p suppression inhibited the proliferative and invasive abilities of gastric cancer cells.
other	34337857	hsa-mir-21	Adenocarcinoma of Lung	These results provide evidence that the lncRNA CASC2/miR-21/p53 form a positive feedback loop to mediate cell proliferation and apoptosis in LUAD, which may provide a new insight into the pathological mechanisms of LUAD.
other	34337826	hsa-mir-1275	Squamous Cell Carcinoma of Head and Neck	phosphate dehydrogenase 1 like interaction pairs may play a central role in LSCC.
other	34337826	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	phosphate dehydrogenase 1 like interaction pairs may play a central role in LSCC.
circulation_biomarker_diagnosis_up	34337736	hsa-mir-130b	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-4433a	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-584	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-501	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-142	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-29a	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-16-2	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-363	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-29b	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-4433b	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
circulation_biomarker_diagnosis_up	34337736	hsa-mir-222	Thrombocytopenia	Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR
lncRNA target	34337719	hsa-mir-22	Enterocolitis, Necrotizing	Silencing IRF5 or over-expressing miR3p relieved the role of lncRNA ENO1-IT1 on inflammation in NEC via CD206 and CD86 expression.
genetics_knock down_suppress	34337714	hsa-mir-24	Prostatic Neoplasms	3p or knockdown of JPT1 could partially reverse the effects of HOXA11-AS overexpression on PCa cell behaviors.
other	34337713	hsa-mir-1205	Colorectal Neoplasms	CONCLUSIONS: In sum, our study demonstrated that ELFN1-AS1 sponges miR-1205 to upregulate MTA1, which is essential for CRC cell proliferation, migration, and invasion as well as apoptosis induction.
genetics_overexpression_promote	34337085	hsa-mir-100	Carcinoma, Hepatocellular	Overexpression of miR-100 attenuates the invasive and proliferative abilities of hepatocellular carcinoma cells by targeting CXCR7.
lncRNA target	34337058	hsa-mir-186	Cholangiocarcinoma	Overall, these results demonstrated that the lncRNA PVT1/miR186/KLF5 axis might exert a key role in the occurrence and progression of CCA, and this axis might provide a new target for treating CCA.
other	34337040	hsa-mir-145	Colonic Neoplasms	5p, lowly expressed in CC, were analyzed in the follow-up study.
other	34337040	hsa-mir-30	Colonic Neoplasms	5p, lowly expressed in CC, were analyzed in the follow-up study.
other	34337017	hsa-mir-142	Syphilis, secondary	And in the blue module, the expression of miR3p was significantly higher in secondary syphilis patients than in healthy controls (p = 0.02), which is also close to the clinical features of secondary syphilis.
exosome	34336922	hsa-mir-221	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-let-7d	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-mir-24	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-mir-193a	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-mir-98	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-mir-130a	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
exosome	34336922	hsa-mir-1273a	Respiratory Distress Syndrome	By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR
genetics_overexpression_promote	34336838	hsa-mir-545	Esophageal Squamous Cell Carcinoma	Rescue experiments revealed that overexpression of MT1M largely restores miR
virus_miRNA	34336826	ebv-mir-BART12	Nasopharyngeal Carcinoma	This miRNA is a member of one 6-miRNA Prognostic Signature in Nasopharyngeal Carcinoma
genetics_knock down_suppress	34336825	hsa-mir-21	Laryngeal Neoplasms	CONCLUSION: Knockdown of circ_PVT1 prevented LC progression via targeting miR
lncRNA target	34336706	hsa-mir-20b	Carcinoma, Renal Cell	Moreover, miR-20b-5p was identified as a potential miRNA target of CTLA4 in KIRC. CONCLUSION: Our study clarified the prognostic value of several immune checkpoint regulators in KIRC, revealing a CTLA4/miR-20b-5p axis in the control of immune cell infiltration in the tumor microenvironment.
circulation_biomarker_diagnosis_up	34336682	hsa-mir-130b	Stomach Neoplasms	For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development.
circulation_biomarker_diagnosis_up	34336682	hsa-mir-151a	Stomach Neoplasms	For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development.
circulation_biomarker_diagnosis_up	34336682	hsa-mir-15b	Stomach Neoplasms	For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development.
other	34336642	hsa-mir-214	Carcinoma, Hepatocellular	In conclusion, we found that a novel lncRNA SNHG3/miR3p/ASF1B axis could promote the recurrence of HCC by regulating immune infiltration.
lncRNA target	34336268	hsa-mir-10a	Carotid Artery Diseases	Moreover, GATA6/VCAM-1 (a downstream target of miR-10a) was highly expressed in the endothelium, accompanied by the reduced levels of miR-10a during the development of human atherosclerosis.
genetics_overexpression_promote	34336153	hsa-mir-130	Carcinoma, Hepatocellular	3p overexpression considerably facilitates apoptosis and suppresses the migration or proliferation of HCC cells.
circulation_biomarker_diagnosis_ns	34336102	hsa-mir-23b	Ovarian Neoplasms	Therefore, we highlight that the LINC00909/miR-23b-3p/MRC2 axis is implicated in the pathogenesis of ovarian cancer, and serum LINC00909 may be a promising biomarker for the diagnosis of OC.
target gene	34336032	hsa-mir-107	Leukemia, Myeloid, Acute	MicroRNA-107 promotes apoptosis of acute myelocytic leukemia cells by targeting RAD51.
genetics_knock down_promote	34336031	hsa-mir-130b	Urinary Bladder Neoplasms	CONCLUSIONS: High expression of miR-130b is negatively related to doxorubicin sensitivity in BUC, and knockdown of miR-130b improves doxorubicin sensitivity in BUC by negatively regulating CYLD expression.
target gene	34336030	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	MicroRNA 144 inhibits cell migration and invasion and regulates inflammatory cytokine secretion through targeting toll like receptor 2 in non-small cell lung cancer.
other	34336002	hsa-mir-487a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our study highlighted the significance of the TSPEAR-AS2/miR-487a-3p/PPM1A axis within OSCC progression and offered a novel biomarker and novel strategies for OSCC treatments.
genetics_overexpression_promote	34335967	hsa-mir-185	Hyperglycemia	In contrast, overexpression of miR
transcription factor target	34335967	hsa-mir-185	Diabetes Mellitus	Furthermore, metformin, an anti-diabetic drug, could upregulate miR5p expression to suppress G6Pase, leading to hepatic gluconeogenesis inhibition.
lncRNA target	34335948	hsa-mir-627	Carcinoma, Hepatocellular	5p suppresses HCC progression via targeting BCL3/CCND1 pathway.
lncRNA target	34335946	hsa-mir-133	Squamous Cell Carcinoma of Head and Neck	Taken together, our mammal-to-Drosophila-to-mammal approach successfully validates targeting of PDE1C by miR-133 both in vivo and in vitro, underlying the promoted EMT phenotypes and potentially influencing the prognosis of oral cancer patients.
transcription factor target	34335939	hsa-mir-187	Squamous Cell Carcinoma of Head and Neck	3p enhanced migration and invasion by targeting PER2 in HNSCCs.
circulation_biomarker_diagnosis_up	34335917	hsa-mir-155	Macular Edema	5p was highly expressed in the aqueous humor (AH) and plasma of patients with DME compared with that in patients with MH, and this was even higher in the refractory DME group.
transcription factor target	34335907	hsa-mir-103	ankylosing spondylitis 1	A dual-luciferase assay verified that miR-103 binds to the 3'-untranslated region end of Rock1 mRNA, thus negatively regulating the activity of Rock1 and affecting pathological ossification during AS. Furthermore, tail suspension could inhibit the activation of mechanical kinase ROCK1 and p-Erk1/2 in the MAPK signaling pathway by upregulating miR-103, thereby inhibiting the classical osteogenesis-related Wnt/beta-catenin pathway in AS.
other	34335906	hsa-mir-223	Sepsis	Thus, it was demonstrated that miR-223 negatively regulated the expression of IL-6, mediating the TLR4/NF-kappaB signaling pathway and exerting an anti-inflammatory effect in sepsis-induced lung injury.
other	34335906	hsa-mir-223	Lung Injury	Thus, it was demonstrated that miR-223 negatively regulated the expression of IL-6, mediating the TLR4/NF-kappaB signaling pathway and exerting an anti-inflammatory effect in sepsis-induced lung injury.
target gene	34335889	hsa-mir-143	Urinary Bladder Neoplasms	Long non-coding RNA PCAT6 regulates bladder cancer progression via the microRNA-143-3p/PDIA6 axis.
genetics_overexpression_suppress	34335864	hsa-mir-182	Adenocarcinoma of Lung	Overexpression of miR
other	34335801	hsa-mir-27b	Adenocarcinoma of Lung	Microarrays and micro-RNA sequencing data suggested that there is a higher level of miR-27b and miR-92a in LUAD tissues than in non-LUAD tissues. In conclusion, mangiferin likely regulates proliferation and apoptosis in LUAD cells by reducing the expression levels of miR-92a and miR-27b.
other	34335801	hsa-mir-92a	Adenocarcinoma of Lung	Microarrays and micro-RNA sequencing data suggested that there is a higher level of miR-27b and miR-92a in LUAD tissues than in non-LUAD tissues. In conclusion, mangiferin likely regulates proliferation and apoptosis in LUAD cells by reducing the expression levels of miR-92a and miR-27b.
genetics_knock down_suppress	34335760	hsa-mir-195	Colorectal Neoplasms	CONCLUSIONS: AFAP1-AS1 knockdown may inhibit the proliferation, migration, and invasion of CRC cells through the miR
lncRNA target	34335757	hsa-mir-378c	Colorectal Neoplasms	Then, ENCORI database (http://starbase.sysu.edu.cn/) was employed to predict that miR-378c was downregulated dramatically in CRC and E2F7 was the direct target of miR-378c. QRT-PCR (quantitative real-time polymerase chain reaction) was conducted to verify that the expression level of miR-378c was decreased while E2F7 expression was upregulated in CRC tissues compared with para-carcinoma tissues.
other	34335755	hsa-mir-493	Stomach Neoplasms	5p to upregulate MAP3K2 expression.
target gene	34335753	hsa-mir-193a	Stomach Neoplasms	miR-193a Directly Targets PSEN1 and Inhibits Gastric Cancer Cell Growth, the Activation of PI3K/Akt Signaling Pathway, and the Epithelial-to-Mesenchymal Transition.
lncRNA target	34335751	hsa-mir-489	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Metformin inhibits HSCC progression through the circ_0003214/miR3p/ADAM10 pathway.
other	34335565	hsa-mir-146a	Lupus Erythematosus, Systemic	The miRNA-mRNA network showed that hsa-miR-146a might regulate the shared IFN-induced genes, which might play an important role in PAH secondary to SLE.
other	34335565	hsa-mir-146a	Pulmonary Arterial Hypertension	The miRNA-mRNA network showed that hsa-miR-146a might regulate the shared IFN-induced genes, which might play an important role in PAH secondary to SLE.
genetics_knock down_promote	34334630	hsa-mir-27b	Uterine Cervical Neoplasms	In the mechanism study, miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+) CC cells. CONCLUSIONS: LncRNA AFAP1-AS1 knockdown inhibits the CC cell stemness by upregulating miR-27b-3p to suppress VEGF-C.
genetics_overexpression_promote	34334583	hsa-mir-185	Cardiomyopathies	Overexpression of miR-3185 inhibited the upregulation of Col I and Col III induced by TGF-beta1.MHRT promoted cardiac fibrosis after MI through miR-3185 and increased myocardial collagen deposition and promoted myocardial fibrosis.
genetics_overexpression_promote	34334583	hsa-mir-185	Myocardial Infarction	Overexpression of miR-3185 inhibited the upregulation of Col I and Col III induced by TGF-beta1.MHRT promoted cardiac fibrosis after MI through miR-3185 and increased myocardial collagen deposition and promoted myocardial fibrosis.
transcription factor target	34334400	hsa-mir-96	Alzheimer Disease	5p in AD models could reduce Abeta42/Abeta40 ratios via upregulating the expression of ABCA1, indicating that miR
circulation_biomarker_prognosis_ns	34334379	hsa-mir-100	Uterine Cervical Neoplasms	CONCLUSIONS: Serum miR-100 may be a useful diagnostic biomarker for CC, and for predicting lymph node metastasis and disease free survival in CC patients.
genetics_knock down_promote	34334103	hsa-mir-2355	Adenocarcinoma of Lung	Knockdown of miR
lncRNA target	34334080	hsa-mir-24	Nerve Degeneration	In conclusion, our work demonstrated that Dex improved OGD/R-induced neurological injury via SNHG11/miR3p/VEGFA axis.
other	34333815	hsa-mir-451a	Mouth Neoplasms	MiR-144 and miR-451a are deregulated in various cancers but the combined regulatory role of miR-144/451a cluster in oral squamous cell carcinoma (OSCC) remains unexplored.
lncRNA target	34333815	hsa-mir-144	Mouth Neoplasms	CONCLUSION: miR-144/451a cluster functions as a tumor suppressor in OSCC by inhibiting cancer cell invasion, migration, and clonogenic potential.
lncRNA target	34333213	hsa-mir-4731	Nasopharyngeal Carcinoma	CONCLUSIONS: Long noncoding RNA ANCR suppresses malignant behaviors of nasopharyngeal carcinoma cells by regulating miR5p/NMT1 axis.
circulation_biomarker_diagnosis_up	34333083	hsa-mir-150	Acute Kidney Injury	5p was down-regulated in the serum of patients with septic AKI (compared to healthy volunteers).
target gene	34332611	hsa-mir-146b	Urinary Bladder Neoplasms	Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling.
other	34332589	hsa-mir-223	Death, Sudden, Cardiac	3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD.
other	34332589	hsa-mir-3113	Death, Sudden, Cardiac	3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD.
other	34332589	hsa-mir-499a	Death, Sudden, Cardiac	3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD.
other	34332589	hsa-mir-133a	Death, Sudden, Cardiac	3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD.
exosome	34331784	hsa-mir-34c	Lung Injury	We found that rno-miR-34c-3p was downregulated in MSCs cocultured with ALI exosomes. In conclusion, ALI exosomes decrease the miR-34c-3p expression levels, influencing MSCs via the JAK1/STAT3 signaling pathway.
other	34331613	hsa-mir-149	Pulmonary Disease, Chronic Obstructive	5p may be a key factor in PM(2.5)-induced COPD.
other	34331612	hsa-mir-128	Multiple Myeloma	3p to increase PLAGL2 expression.
transcription factor target	34331478	hsa-mir-155	Atherosclerosis	This study provides a fundamental insight on the miR-155 mechanism for PAHs enhancing atherosclerosis and miR-155 potentially serving as a novel drug target.
genetics_overexpression_promote	34331407	hsa-mir-140	Hypoxia-Ischemia, Brain	The OGD-induced impaired cell viability, enhanced cell apoptosis, and activated neuroinflammation were abrogated by the overexpression of miR-140 in both PC12 and SH-SY5S cells.
circulation_biomarker_diagnosis_down	34331407	hsa-mir-410	Hypoxia-Ischemia, Brain	CONCLUSION: All data revealed that serum downregulated miR-410 in HIE serves as candidate diagnostic biomarker, and that miR-410 exerts a neuroprotective role in OGD-injured cells by improving cell viability and inhibiting cell apoptosis through targeting PTEN.
tissue_expression_ns	34331175	hsa-mir-130	Inflammation	In conclusion, we proved Se deficiency could induce the deregulation of miRCYLD axis to cause RIPK3-dependent necroptosis and inflammation in pig cerebellum.
tissue_expression_ns	34331175	hsa-mir-130	Necrosis	In conclusion, we proved Se deficiency could induce the deregulation of miRCYLD axis to cause RIPK3-dependent necroptosis and inflammation in pig cerebellum.
other	34331128	hsa-mir-21	Carcinoma, Endometrioid	In particular, in endometrioid carcinoma, high miR-21 expression in cancer cells was an independent prognostic factor associated with poor progression-free survival, as well as older age and higher International Federation of Gynecology and Obstetrics (FIGO) stage.
other	34330446	hsa-mir-362	Inflammatory Bowel Diseases	We applied this platform successfully for miR-362, a potential biomarker of inflammatory bowel diseases (IBD), or HIV-related DNA (hDNA) detection, achieving the detection limits of 6.5 nM and 1.7 nM, respectively.
lncRNA target	34330309	hsa-mir-35	Polycystic Ovary Syndrome	CONCLUSIONS: TMPO-AS1 might suppress miR5p maturation to participate in PCOS.
lncRNA target	34330307	hsa-mir-137	Rheumatic Fever	CONCLUSION Circ_0025908 facilitates the development of RA through increasing HIPK2 expression by regulating miR-137, which also offered an underlying targeted therapy for RA treatment.
circulation_biomarker_diagnosis_up	34330158	hsa-mir-222	Acute Coronary Syndrome	Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS.
circulation_biomarker_diagnosis_up	34330158	hsa-mir-221	Acute Coronary Syndrome	Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS.
lncRNA target	34329919	hsa-mir-124	Glioblastoma	This work indicated that our new polymeric nanoparticles successfully mediate inhibition of miR-21 and miR-124 supplementation to significantly reduce tumorigenesis, and may have strong potential in GBM therapy.
lncRNA target	34329919	hsa-mir-21	Glioblastoma	This work indicated that our new polymeric nanoparticles successfully mediate inhibition of miR-21 and miR-124 supplementation to significantly reduce tumorigenesis, and may have strong potential in GBM therapy.
genetics_overexpression_promote	34329839	hsa-mir-1343	Colorectal Neoplasms	3p overexpression or PARP1 down-regulation affected the biological behaviors of CRC cells.
genetics_knock down_promote	34329837	hsa-mir-205	Liver Neoplasms	Loss of CDKL3 impaired the malignant activities of liver cancer cells, and could even impair the pro-tumor effects of down-regulated exosomal miR
genetics_GWAS	34329686	hsa-mir-378a	Muscular Dystrophy, Duchenne	Increased levels of miR-378a were reported in the serum of Duchenne muscular dystrophy (DMD) patients and female carriers of DMD gene-associated mutations with developed cardiomyopathy. In order to shed more light on the role of miR-378a in human cardiomyocytes and its potential involvement in DMD-related cardiomyopathy, we generated two human induced pluripotent stem cell (hiPSC) models; one with deletion of miR-378a and the second one with deletion of DMD exon 50 leading to the DMD phenotype.
other	34329686	hsa-mir-378a	Hypertrophy	It was observed that miR-378a protects cardiomyocytes from hypertrophic growth by regulation of IGF1R and the expression of downstream kinases. miR-378a-deficient hiPSC-CM exhibited, however, significantly bigger size compared to the isogenic control cells, indicating the role of this miRNA in the hypertrophic growth of human cardiomyocytes.
genetics_GWAS	34329686	hsa-mir-378a	Cardiomyopathies	Increased levels of miR-378a were reported in the serum of Duchenne muscular dystrophy (DMD) patients and female carriers of DMD gene-associated mutations with developed cardiomyopathy. In order to shed more light on the role of miR-378a in human cardiomyocytes and its potential involvement in DMD-related cardiomyopathy, we generated two human induced pluripotent stem cell (hiPSC) models; one with deletion of miR-378a and the second one with deletion of DMD exon 50 leading to the DMD phenotype.
other	34329656	hsa-mir-155	Atherosclerosis	5p, were subjected to validation by RT-qPCR in normal arteries and also in pathological/atheroma counterparts, considering all the available 20 artery specimens.
other	34329475	hsa-mir-15a	Lung Diseases	Conclusion: SeMet could reduce the oxidative damage and activate NLRP3 inflammasome reaction by stimulating miR-15a/JNK, thus reduced the pulmonary necroptosis induced by LPS.
other	34329475	hsa-mir-15a	Carcinoma, Hepatocellular	To further study these mechanisms, we established a supplement of selenomethionine (SeMet) and/or LPS-treated chicken model and a cell model of LPS and/or high and low expression of miR-15a in chicken hepatocellular carcinoma (LMH) cells.
lncRNA target	34329471	hsa-mir-339	Breast Neoplasms	In 157 paired breast cancer and adjacent normal samples, tumour suppressor gene GPER1 and miR-339 are both downregulated in Luminal A/B and Triple Negative Breast Cancer subtypes. Mechanistic investigations revealed that miR-339 upregulates GPER1 expression in breast cancer cells by switching on the GPER1 enhancer, which can be blocked by enhancer deletion through the CRISPR/Cas9 system.
other	34329340	hsa-mir-99a	Esophageal Squamous Cell Carcinoma	Survival univariate/multivariate COX analysis revealed that five genes, ZBTB16, AQP4, ADCYAP1R1, PDGFD, and VIPR2, and two microRNAs, miR-99a-5p, and miR5p, were related to esophageal cancer prognosis.
other	34329193	hsa-mir-370	Breast Neoplasms	circFOXK2 could act with IGF2BP3, an RNA-binding protein, and miR-370 to synergistically promote BC metastasis. In conclusion, circFOXK2 functions as a key regulator in BC metastasis, and the role of circFOXK2 on BC metastasis is tightly associated with the involvement of IGF2BP3 and miR-370.
circulation_biomarker_diagnosis_ns	34328678	hsa-mir-126	Glioblastoma	Furthermore, LINC00511 was mainly distributed in the cytoplasm of GBM cells and regulated Wnt/beta-catenin activation by acting as a molecular sponge for miR
lncRNA target	34328265	hsa-mir-4691	Liver Neoplasms	CONCLUSIONS: We suggest that TPRG1-AS1 is a novel ceRNA sponging miR5p and miR-3659, resulting in RBM24 expression and suppression of liver cancer growth.
lncRNA target	34328198	hsa-mir-184	Prostatic Neoplasms	On the whole, the findings of the present study suggest that SNHG11 expression is upregulated in PCa and that it facilitates PCa progression, at least in part, via the modulation of the miR184/IGF1R signaling axis.
lncRNA target	34328197	hsa-mir-29a	Osteosarcoma	In addition, H19 served as a competing endogenous ncRNA targeting microRNA29a3p and activating LIM and SH3 domain protein 1 and modulating the OS cell phenotype.
lncRNA target	34328196	hsa-mir-351	Acute Lung Injury	In conclusion, the present study indicated that miR3515p aggravated LPSinduced ALI via inhibiting AMPK, suggesting that targeting miR3515p may help to develop efficient therapeutic approaches for treating ALI.
lncRNA target	34328193	hsa-mir-429	Adenocarcinoma of Lung	In conclusion, interference of circPVT1 inhibits the progression of lung ADC and enhances its sensitivity to DDP via miR429/FOXK1, which may provide a theoretical basis for the use of novel targets in the treatment of lung ADC.
exosome	34327982	hsa-mir-10b	Pancreatic Carcinoma	Moreover, the biosensor was further used to detect exosomal miRNA-10b derived from pancreatic cancer cells and normal pancreatic cells.
genetics_overexpression_promote	34327529	hsa-mir-23a	Breast Neoplasms	Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance.
transcription factor target	34327240	hsa-mir-214	Pituitary Diseases	3p could protect VECs from ROS-induced endothelial dysfunction by reversing its inhibitory effect on GPX4 expression.
other	34327234	hsa-mir-4435-2	Inflammatory Bowel Disease 11	lncRNA MIR4435-2HG is a variable in the decision tree for moderate-to-severe UC diagnostic prediction.
exosome	34326916	hsa-mir-218	Myocardial Infarction	In summary, these results show that the protective ability of EPC-Exos against MI was mediated by the shuttled miR
exosome	34326916	hsa-mir-363	Myocardial Infarction	In summary, these results show that the protective ability of EPC-Exos against MI was mediated by the shuttled miR
genetics_knock down_suppress	34326893	hsa-mir-144	Squamous Cell Carcinoma of Head and Neck	In conclusion, our study confirmed the loss or downregulation of miR
genetics_knock down_promote	34326879	hsa-mir-129	Osteoporosis	5p/Dkk3 axis may be new potential targets for the treatment of bone defect and bone loss.
genetics_knock down_promote	34326879	hsa-mir-129	Bone Diseases	5p/Dkk3 axis may be new potential targets for the treatment of bone defect and bone loss.
other	34326714	hsa-mir-26a	Bone Diseases	We finally examined the efficacy of HA-SS-PGEA/miR-26a NPs loaded 3D hybrid nanofiber aerogels showing a positive effect on the cranial bone defect healing.
circulation_biomarker_prognosis_up	34326690	hsa-mir-214	Osteosarcoma	3p silence/over-expression with or without cantharidin treatment, and nuclear/cytoplasmic protein assay in osteosarcoma cells.
circulation_biomarker_diagnosis_up	34326666	hsa-mir-613	Triple Negative Breast Neoplasms	RESULTS: TNBC patients receiving ADD adjuvant therapy after chemotherapy, with decreased serum level of hsa_circ_0001982 and increased serum level of miR-206/miR-613 as relative to non-ADD treatment group (P<0.05), were less likely to relapse than TNBC population not undergoing ADD treatment (P<0.05).
circulation_biomarker_diagnosis_up	34326666	hsa-mir-206	Triple Negative Breast Neoplasms	RESULTS: TNBC patients receiving ADD adjuvant therapy after chemotherapy, with decreased serum level of hsa_circ_0001982 and increased serum level of miR-206/miR-613 as relative to non-ADD treatment group (P<0.05), were less likely to relapse than TNBC population not undergoing ADD treatment (P<0.05).
circRNA target	34326457	hsa-mir-340	Colorectal Neoplasms	Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment.
lncRNA target	34326275	hsa-mir-431	Uterine Cervical Neoplasms	These results demonstrated that circSPIDR suppresses cervical adenocarcinoma by competitively binding to miR
other	34326064	hsa-mir-199a	Spinal Cord Injuries	MicroRNAs (miRs) have been implicated in regulation of PTEN and mTOR expression, and previous work in spinal cord showed an increase in miR-199a-3p after spinal cord injury (SCI) and increase in miR-21 in SCI animals that had undergone exercise.
other	34326064	hsa-mir-21	Spinal Cord Injuries	MicroRNAs (miRs) have been implicated in regulation of PTEN and mTOR expression, and previous work in spinal cord showed an increase in miR-199a-3p after spinal cord injury (SCI) and increase in miR-21 in SCI animals that had undergone exercise.
genetics_overexpression_promote	34325604	hsa-mir-654	Arthritis, Rheumatoid	Furthermore, FZD4 overexpression also reversed the effects of miR
lncRNA target	34325283	hsa-mir-26b	Osteoarthritis	induced OA progression via circ_SEC24A/miR-26b-5p/DNMT3A ceRNA axis.
lncRNA target	34325277	hsa-mir-26b	Arthritis, Rheumatoid	CONCLUSION: MiR-26b-5p may affect the biological characteristics of RA-FLS via targeting EZH2, including proliferation, apoptosis, invasion and migration, as well as the secretion of cytokines, thus playing a potential therapeutic role in RA.
other	34324865	hsa-mir-211	Reperfusion Injury, Cerebral Ischemia	5p and is then regulating the expression of COX-2.
transcription factor target	34324740	hsa-mir-148a	Colorectal Neoplasms	These results reveal that miR-148a-3p can function as a tumor promotor in CRC by targeting the CANX/MHC-I axis, which provides a rationale for immunotherapy through targeting the miR-148a-3p/CANX/MHC-I pathway in patients with CRC.
genetics_knock down_promote	34324278	hsa-mir-1296	Triple Negative Breast Neoplasms	miR-1296 interacted with the 3' untranslated region (3'UTR) of ZFX, and ZFX overexpression partly reversed miR-1296 overexpression-mediated effects in TNBC cells.
lncRNA target	34324029	hsa-mir-153	Breast Neoplasms	3p was found to modulate breast cancer cell carcinogenesis via targeting CFL2.
lncRNA target	34323695	hsa-mir-486	Breast Neoplasms	5p and tamoxifen exhibit additive and synergistic tumor-suppressive effects, most importantly causing profound cell death specifically in tamoxifen-resistant BC cells.
transcription factor target	34323631	hsa-mir-670	Glioblastoma	3p can be an alternative, at least adjuvant strategy to treat glioblastoma.
lncRNA target	34323178	hsa-mir-101	Uterine Cervical Neoplasms	Finally, the interaction between PTAR and miR-101 in uterine cancer was verified through a dual-luciferase reporter assay and correlation analysis.
lncRNA target	34323174	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	We confirmed that COX10-AS1 down-expression can restore the inhibitory effect of miR5p on PAICS, promote the apoptosis of NSCLC cells, and inhibit the proliferation of NSCLC cells.
genetics_knock down_promote	34323000	hsa-mir-16	Thyroid Neoplasms	Collectively, circZFR knockdown retarded TC progression by sponging miR-16 and modulating MAPK1 expression.
lncRNA target	34322902	hsa-mir-21	psoriasis 1	BACKGROUND: Expression of microRNA-21 (miR-21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP-3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFalpha) sheddase TACE (TNFalpha-converting enzyme)/ADAM17.
lncRNA target	34322848	hsa-mir-338	Glioma	3p exerted profound inhibition effects on GBM cell growth in vitro or in vivo through targeting Prex2, leading to attenuation of (Protein kinase B) AKT/Signal transducer and activator of transcription 3 (STAT3) signaling activation.
other	34322788	hsa-mir-3164	Nasopharyngeal Carcinoma	The LINC00324/miR-3164/PAD4 axis modulated the PI3K/AKT pathway in NPC cells.
genetics_knock down_suppress	34322757	hsa-mir-485	Colorectal Neoplasms	Circ_0007031 knockdown repressed CRC malignant progression by reducing MELK expression through associating with miR
circulation_biomarker_diagnosis_ns	34322647	hsa-mir-200a	Pituitary Neoplasms	Our results depicted a miR-200a and lncRNA ANRIL expression in tissue and plasma samples in the patients with invasive PA.
other	34322490	hsa-mir-205	Ovarian Neoplasms	HOTTIP-miR-205-ZEB2 Axis Confers Cisplatin Resistance to Ovarian Cancer Cells.
other	34322482	hsa-mir-494	Hyperglycemia	Pharmacological ER stress inducers (tunicamycin (TCN) and thapsigargin) and hyperglycemia robustly increase the expression of miR-494 in vitro.
lncRNA target	34322386	hsa-mir-143	Carcinoma, Hepatocellular	CONCLUSION: SOX2-OT inhibited the targeted inhibition of miR
circulation_biomarker_diagnosis_up	34321907	hsa-mir-365	Hypertension	CONCLUSION: The miR-365 serum expression in patients with LVH-accompanied HT was increased compared with the observation group and the control group and positively correlated with the LVH degree.
circulation_biomarker_diagnosis_up	34321907	hsa-mir-365	Hypertrophy, Left Ventricular	CONCLUSION: The miR-365 serum expression in patients with LVH-accompanied HT was increased compared with the observation group and the control group and positively correlated with the LVH degree.
circulation_biomarker_diagnosis_ns	34321587	hsa-mir-210	Sepsis	Taken together, the key findings of the current study demonstrate that plasma EVs carrying miR
circulation_biomarker_diagnosis_ns	34321587	hsa-mir-210	Acute Lung Injury	Taken together, the key findings of the current study demonstrate that plasma EVs carrying miR
genetics_GWAS	34321465	hsa-mir-361	Glioma	Loss/gain-of-function method was applied to determine the roles of miR
exosome	34321461	hsa-mir-1260b	Carcinoma, Non-Small-Cell Lung	In conclusion, exosomal miR-1260b can promote angiogenesis in HUVECs and metastasis of NSCLC by regulating HIPK2 and may serve as a prognostic marker for lung cancers.
other	34321456	hsa-mir-526b	Lung Neoplasms	We found that miR-526b-3p expression declined while PD-L1 was elevated in cisplatin-resistant lung cancer compared to that in cisplatin-sensitive lung cancer by analyzing clinical samples.
other	34321402	hsa-mir-221	Atherosclerosis	In conclusion, circSCAP facilitated lipid accumulation, inflammation, and oxidative stress in ox-LDL-induced THP-1 macrophages by regulating miR5p/PDE3B axis.
lncRNA target	34321385	hsa-mir-215	Heart Failure	In conclusion, SOX2-OT aggravated heart failure in vivo and promoted H9c2 cell injury via the miR5p/ZEB2 axis in vitro, implying a novel insight into heart failure treatment.
genetics_knock down_promote	34321174	hsa-mir-195	Stomach Neoplasms	In conclusion, our study suggested that IGF2-AS knockdown suppressed glycolysis and facilitated apoptosis in GC cells at least partly through sponging miR-195 and modulating CREB1 expression, highlighting a novel therapeutic strategy for GC treatment.
lncRNA target	34321149	hsa-mir-142	Breast Neoplasms	5p, which inhibits the expression of DNMT1 by targeting the 3-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer.
other	34321097	hsa-mir-29c	Diabetes Mellitus	While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).
lncRNA target	34321010	hsa-mir-194	Carcinoma, Non-Small-Cell Lung	5p bound to the 3' untranslated region (3'UTR) of HOOK3 mRNA for its inhibition.
transcription factor target	34320900	hsa-mir-20a	Carcinoma, Squamous Cell, Cutaneous	Crocin can target ATG2B/miR-320a and may be an effective alternative for cSCC treatment.
circulation_biomarker_prognosis_ns	34320871	hsa-mir-675	Atherosclerosis	The clinical diagnostic significance of serum miR
lncRNA target	34320711	hsa-mir-22	Breast Neoplasms	3p could suppress the proliferation of breast cancer by targeting PLAGL2.
lncRNA target	34320692	hsa-mir-6717	Lung Neoplasms	In particular, hsa_circ_0051488 binds to mir5p, thereby modulating the expression of SATB2 gene, a lung cancer suppressor.
other	34320692	hsa-mir-6717	Syphilis	These findings suggest a possible regulatory mechanism of hsa_circ_0051488 in LUSC, and that the newly discovered hsa_circ_0051488/miR5p/SATB2 axis may be a potential route for therapeutic intervention of LUSC.
transcription factor target	34320373	hsa-mir-200c	Diabetes Mellitus, Type 2	Collectively, these studies establish that miR-200c plays an important role in T2D, and small molecules targeting RNA structure can be an important complement to oligonucleotides.
circRNA target	34320370	hsa-mir-497	Colorectal Neoplasms	RESULTS: The results showed that hsa_circ_0136666 and PD-L1 was increased in colorectal cancer cells while miR-497 was decreased in colorectal cancer cells when compared with normal colon epithelial cell line. CONCLUSIONS: Our findings demonstrated that hsa_circ_0136666 promoted the expression of PD-L1 by inhibiting miR-497 level in colorectal cancer, thus inducing the activation of Treg cells and leading to the immune escape of tumor, providing a novel mechanistic insight into the pathogenesis of colorectal cancer.
circRNA target	34320120	hsa-mir-106a	Colorectal Neoplasms	Together, these findings showed that circEGFR promoted CRC cell proliferation, migration, and invasion through the miR-106a-5p/DDX5/AKT axis, and may serve as a promising diagnostic marker and therapeutic target for CRC patients.
other	34320033	hsa-mir-223	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320033	hsa-mir-486	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320033	hsa-mir-27a	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320033	hsa-mir-506	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320033	hsa-mir-126	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320033	hsa-mir-23a	Carcinoma, Ovarian Epithelial	3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature.
other	34320031	hsa-mir-423	COVID-19	5p) independently classified COVID-19 cases with an accuracy of 99.9%.
other	34320031	hsa-mir-23a	COVID-19	5p) independently classified COVID-19 cases with an accuracy of 99.9%.
other	34320031	hsa-mir-195	COVID-19	5p) independently classified COVID-19 cases with an accuracy of 99.9%.
genetics_knock down_promote	34319909	hsa-mir-490	Prostatic Neoplasms	3p or up-regulation of FRAT1 reversed the suppressive effects of CCAT1 knockdown on the PCa cells.
transcription factor target	34319904	hsa-mir-17	congenital nongoitrous hypothyroidism 4	Using HTR-8/SVneo cells, we demonstrated that elevated TSH inhibited miR
other	34319904	hsa-mir-17	Sjogren's Syndrome	Compared with normal pregnant women, miR5p was decreased and zinc finger protein 367 (ZNF367) was upregulated in the chorionic villi of TSH > 2.5 mIU/L-related SA patients.
circulation_biomarker_prognosis_ns	34319554	hsa-mir-590	Heart Failure, Chronic	This study found that the serum levels of ZFAS1 were significantly higher, while miR
circulation_biomarker_diagnosis_ns	34319544	hsa-mir-23a	Infertility, Male	We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters.
circulation_biomarker_diagnosis_ns	34319544	hsa-mir-146a	Infertility, Male	We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters.
circulation_biomarker_diagnosis_ns	34319544	hsa-mir-34a	Infertility, Male	We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters.
other	34319204	hsa-mir-34a	Ovarian Neoplasms	MicroRNA-mediated gene therapy is emerging as a promising method for the treatment of ovarian cancer, but the development of miRNA mimic delivery vectors is still in its infancy, where the safety and efficacy of miR-34a-mimic remain unknown. In summary, UTMD-mediated miR-34a-mimic delivery has potential application in the clinical treatment of ovarian cancer.
target gene	34319136	hsa-mir-486	Osteoarthritis	MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6 : possible involvement in cartilage degradation in osteoarthritis.
lncRNA target	34319043	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	CONCLUSIONS: Our data propose that suppression of Bcl-2 and Mcl-1 by miRNA-15a can effectively inhibit the cell proliferation and sensitize CLL cells to fludarabine.
circulation_biomarker_diagnosis_ns	34319042	hsa-mir-138	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our findings suggest that the evaluation of miR-138 and miR5p expression in serum can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future.
circulation_biomarker_diagnosis_ns	34319042	hsa-mir-424	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Our findings suggest that the evaluation of miR-138 and miR5p expression in serum can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future.
circulation_biomarker_prognosis_ns	34318932	hsa-mir-22	Lymphoma, Large B-Cell, Diffuse	Here we validated serum miR-22, an evolutionarily conserved microRNA, as a prognostic/predictive biomarker in DLBCL. These results suggest that miR-22 is a promising complementary or even independent non-invasive biomarker for DLBCL management.
circulation_biomarker_diagnosis_ns	34318873	hsa-mir-155	Pre-Eclampsia	We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation.
circulation_biomarker_diagnosis_ns	34318873	hsa-mir-29b	Pre-Eclampsia	We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation.
circulation_biomarker_diagnosis_ns	34318873	hsa-mir-126	Pre-Eclampsia	We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation.
other	34318873	hsa-mir-16	Pre-Eclampsia	Independent of age and parity, miR-16 was related to impaired FMD (beta 2.771, 95% C.I.: 0.023-5.519, P=0.048) and mFMD (beta 3.401, 95% C.I.: 0.201-6.602, P=0.038).
circulation_biomarker_diagnosis_ns	34318873	hsa-mir-200c	Pre-Eclampsia	Circulating miR-200c was increased in PE and correlated with higher arterial stiffness.
genetics_GWAS	34318684	hsa-mir-181b	Autistic Disorder	A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b).
genetics_GWAS	34318684	hsa-mir-34a	Autistic Disorder	A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b).
genetics_knock down_promote	34318683	hsa-mir-576	Stomach Neoplasms	Overexpressing miR
lncRNA target	34318554	hsa-mir-34a	Drug-Induced Kidney Injury	In this study, the protective effect of betaine against cisplatin-induced nephrotoxicity through modulating the expression of microRNA 34a (miRNA 34a), p53, apoptosis, and inflammation was investigated. In conclusion, cisplatin-induced nephrotoxicity in rats was associated with upregulation of miRNA 34a expression, apoptosis, and inflammation in p53-dependent manner.
transcription factor target	34318435	hsa-mir-125b	Prostatic Neoplasms	3p are potential therapeutic targets against prostate cancer.
transcription factor target	34318435	hsa-mir-221	Prostatic Neoplasms	3p are potential therapeutic targets against prostate cancer.
transcription factor target	34318435	hsa-mir-145	Prostatic Neoplasms	3p are potential therapeutic targets against prostate cancer.
genetics_overexpression_promote	34318428	hsa-mir-802	Osteosarcoma	In addition, miR-802 overexpression inactivated PI3K/AKT pathway via targeting p27 in OS.
target gene	34316513	hsa-mir-338	Osteosarcoma	Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis.
other	34316330	hsa-mir-203a	Head and Neck Neoplasms	We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI.
other	34316330	hsa-mir-194	Head and Neck Neoplasms	We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI.
other	34316330	hsa-mir-10a	Head and Neck Neoplasms	We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI.
other	34315950	hsa-mir-4454	Parkinson Disease	3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis.
other	34315584	hsa-mir-171f	Parastremmatic dwarfism	Meanwhile, the microRNA data showed that the miR171f_3 demonstrated the active involvement in GA pathway response in persimmon dwarfism.
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-22	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-374b	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-199a	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-28	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-151a	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
circulation_biomarker_diagnosis_ns	34315539	hsa-mir-374a	Parkinson Disease	CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR
other	34315491	hsa-mir-99a	Colorectal Neoplasms	A novel miRNA-mRNA network capable of predicting the prognosis and confirmed experimentally, hsa-miR-99a-HS3ST2-hsa-miR-100, was found after expression analysis in metastasized lymph node tissue from CRC samples.
other	34315491	hsa-mir-100	Colorectal Neoplasms	A novel miRNA-mRNA network capable of predicting the prognosis and confirmed experimentally, hsa-miR-99a-HS3ST2-hsa-miR-100, was found after expression analysis in metastasized lymph node tissue from CRC samples.
genetics_overexpression_promote	34314996	hsa-mir-199a	Carcinoma, Hepatocellular	It was also found that miR-199a-5p overexpression declined the development of the cells with HCC and that it could bind to CDC25A to suppress the progression of HCC.
genetics_overexpression_promote	34314948	hsa-mir-4323	Colorectal Neoplasms	miR-4323 overexpression decreased cell proliferation rate via induction of cell apoptosis in colorectal cancer cells.
genetics_overexpression_promote	34314629	hsa-mir-21	Endometrial Neoplasms	A cells, overexpression of circFAT1 increased the expression levels of miR-21 and decreased the methylation of miR-21 gene, whereas overexpression of miR-21 did not alter the expression of circFAT1.
genetics_knock down_promote	34314382	hsa-mir-1252	Pancreatic Carcinoma	5p overexpression inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of PAC cells, and miR
genetics_overexpression_promote	34314379	hsa-mir-198	Carcinoma, Hepatocellular	CircSP3 overexpression in HCC cells induced expression of cyclin-dependent kinase 4, a target gene of miR-198.
genetics_overexpression_promote	34313969	hsa-mir-1299	Stomach Neoplasms	Additionally, the proliferation, apoptosis and metastasis of AGS and SGC7901 cells were analyzed after the overexpression of miR-1299.
transcription factor target	34313929	hsa-mir-93	Diabetic Retinopathy	CONCLUSION: MiR5p, via targeting Sirt1, could affect the vascular permeability and acellular capillaries and mitigate the inflammation and oxidative stress in the retinas, which may play a critical role in DR.
transcription factor target	34313924	hsa-mir-122	Carcinoma, Hepatocellular	5p which inhibits the hallmark glycolytic enzymes and ultimately the metabolic activity of HCC cells.
lncRNA target	34313922	hsa-mir-200b	Esophageal Neoplasms	To explore function of LINC00667/miR-200b-3p/SLC2A3 axis may provide an informative biomarker of malignancy and a highly selective anti-EC therapeutic target.
circRNA target	34313883	hsa-mir-543	Stomach Neoplasms	Our findings demonstrated that enforced expression of circ_0001017 suppressed malignant behaviors and enhanced CDDP sensitivity of CDDP-resistant GC cells at least partially by the miR-543/PHLPP2 axis.
genetics_knock down_suppress	34313802	hsa-mir-1	Cataract, posterior polar, 3	Following adeno-associated virus (AAV)-mediated knockdown or overexpression of miR
other	34313719	hsa-mir-26a	Colorectal Neoplasms	Furthermore, clinical analysis results show that Smad1 is positively correlated with MALAT1 and negatively correlated with miR-26a-5p in CRC samples.
other	34313533	hsa-mir-218	Atherosclerosis	5p/IGF2 axis.
lncRNA target	34313407	hsa-let-7i	Acute Coronary Syndrome	CONCLUSIONS: The present study identified that miR-let-7i significantly reduces Fas and FasL expression in ACS CD4+ T cells and inhibits apoptosis in these cells. Therefore, miR-let-7i may serve as a possible therapeutic target for the treatment of ACS.
lncRNA target	34313353	hsa-mir-296	Carcinoma, Non-Small-Cell Lung	CircWHSC1 silence significantly inhibited colony formation, viability, invasion, and migration, while increased NSCLC cell apoptosis, which were partially rescued by anti-miR
genetics_knock down_promote	34313249	hsa-mir-212	Prostatic Neoplasms	Depletion of exosomal circHIPK3 or overexpression of exosomal miR-212 reduced viability, migration and invasion, but promoted cell apoptosis in PCa cells, which was attenuated by miR-212 inhibition or BMI-1, respectively. Exosomal circHIPK3 knockdown inhibited PCa progression by regulating miR-212/BMI-1 axis, at least in part, offering a new insight into the molecular mechanism of PCa.
genetics_GWAS	34313201	hsa-mir-146a	Gout	CONCLUSION: Our results indicate that there is no evidence for the involvement of the miR-146a rs2910164 polymorphisms in susceptibility to primary gout in the Chinese Han population.
circulation_biomarker_diagnosis_ns	34312906	hsa-mir-122	Fatty Liver	TAM-induced steatohepatitis was evidenced by elevated liver triglycerides and cholesterol contents, increased serum miRNA-122 level, and ALT activity, in parallel with accumulation of lipid droplets, focal necrosis, and inflammatory cells infiltration in hepatocytes.
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-200a	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-29a	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-29a	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-155	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-155	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-21	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-21	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-93	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
other	34312814	hsa-mir-196a	Proteinuria	5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g.
other	34312814	hsa-mir-196a	Renal Insufficiency, Chronic	5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g.
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-214	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-200a	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-214	Renal Insufficiency, Chronic	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
circulation_biomarker_diagnosis_ns	34312814	hsa-mir-93	Proteinuria	3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR
exosome	34312802	hsa-mir-193b	Mastitis	In summary, these findings provide strong evidence that exosomal miR-193b-5p could be a regulator of LPS-induced inflammation in Mac-T cells and reveal a new role of exosomal miRNAs in regulating dairy cow mastitis.
genetics_overexpression_suppress	34312797	hsa-mir-181a	Thyroid Cancer, Papillary	RESULTS: We observed that miR-181a was overexpressed and KLF15 was low expressed in PTC tissues and cell lines.
lncRNA target	34311651	hsa-mir-26a	Nerve Degeneration	In vitro and in vivo results showed that miR-26a delivered by ASC-EVs inhibited neuronal damage.
other	34311651	hsa-mir-26a	Reperfusion Injury	ASC-EVs protected neuronal cells against neuronal damage following cerebral ischemia/reperfusion, which was related to transfer of miR-26a into neuronal cells.
transcription factor target	34311527	hsa-mir-21	Sepsis	In animal model of sepsis, the protective influence of Hyp against sepsis-induced cardiac dysfunction was attenuated by miR-21 upregulation. CONCLUSION: Our findings demonstrated that Hyp may serve as a promising natural drug for the treatment of sepsis-associated cardiac dysfunction, and its protective role may exerted through regulating cardiomyocyte viability and inflammation by suppressing miR-21.
lncRNA target	34311444	hsa-mir-541	Osteoporosis-pseudoglioma syndrome	Overall, MT modulates the osteogenic and adipogenic differentiation of BMSCs by mediating H19/miR3p/APN axis, providing a new reference for the targeted therapy of OP.
other	34311444	hsa-mir-541	Osteoporosis	The results showed that MT, H19 and APN were down-regulated, while miR3p was up-regulated in the OVX rat model.
other	34311393	hsa-mir-146b	Esophageal Neoplasms	RESULTS: The PBMC expression of miR-146b and TNFA was downregulated in ESCC patients as compared to healthy subjects.
lncRNA target	34311261	hsa-mir-1236	Severe Acute Respiratory Syndrome	As a part of our genomics study on host-virus-plant interaction, we identified one unique 3'UTR conserved site 'GGAAGAG' amongst 5024 globally submitted SARS-CoV-2 complete genomes, which can be targeted by the human miRNA 'hsa-miR3p' and by Z.
other	34311261	hsa-mir-477	Severe Acute Respiratory Syndrome	Additionally, we also predicted that the members of miR477 family commonly found in these three plant genomes possess an inherent potential to silence viral genome RNA and facilitate antiviral defense against SARS-CoV-2 infection.
transcription factor target	34311140	hsa-mir-1	Chemical and Drug Induced Liver Injury	CONCLUSIONS: miR-31 can down-regulate Cdc42 to restrict overactivation of reactive oxygen species/JNK/mitochondria necrotic death loop in hepatocytes of APAP-induced DILI, which might provide a new therapeutic target for alleviating JNK overactivation-based liver injury.
genetics_overexpression_suppress	34311013	hsa-mir-497	Myocardial Reperfusion Injury	miR-497 mimics or si-IGF1 blocked the effects of HCP5 overexpression.
other	34310913	hsa-mir-133a	Repolarization Abnormality	Mir-133a-3p induced repolarization abnormalities in the atrial working myocardium and the L-type calcium current (I(Ca,L)) was significantly increased.
lncRNA target	34310900	hsa-mir-194	Cicatrix, Hypertrophic	In conclusion, the findings suggested that H19 may inhibit the apoptosis and promote the proliferation of HSFs through the miR-194/IGF1R/p38 MAPK signaling axis, thereby contributing to the progression of hypertrophic scars.
other	34310833	hsa-mir-214	Acute Heart Failure	CONCLUSION: MiR-214, BNP, NT-proBNP and sST2 can be used as effective biomarkers for AHF, providing a new strategy for diagnosis and for judging the severity of AHF.
circulation_biomarker_diagnosis_ns	34310809	hsa-mir-375	Arthritis, Rheumatoid	CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.
circulation_biomarker_diagnosis_ns	34310809	hsa-mir-224	Arthritis, Rheumatoid	CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.
circulation_biomarker_diagnosis_ns	34310809	hsa-mir-378	Arthritis, Rheumatoid	CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.
circulation_biomarker_diagnosis_ns	34310809	hsa-mir-483	Arthritis, Rheumatoid	CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA.
genetics_knock down_promote	34309414	hsa-mir-205	Uterine Cervical Neoplasms	In conclusion, the overexpression of lncRNA HNRNPU-AS1 suppressed CC progression by inhibiting the Wnt/beta-catenin pathway through the miR
lncRNA target	34308851	hsa-let-7c	Urinary Bladder Neoplasms	CONCLUSION: miR-let-7c-5p inhibits EMT of bladder cancer UM-UC-3 cells by targeting HMGA2, thereby inhibiting the cell invasion and migration.
genetics_knock down_promote	34308850	hsa-mir-424	Carcinoma, Hepatocellular	5p or overexpressing ATG14 significantly promoted cell proliferation and inhibited cell apoptosis (P < 0.05).
lncRNA target	34308776	hsa-mir-9	Reperfusion Injury, Hepatic Ischemia	3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated.
lncRNA target	34308771	hsa-mir-16	Colorectal Neoplasms	Moreover, our results suggest AGAP2-AS1 promoted CRC progression by sponging the hsa-miR-15/16 family and upregulation of their targets.
lncRNA target	34308771	hsa-mir-15	Colorectal Neoplasms	Moreover, our results suggest AGAP2-AS1 promoted CRC progression by sponging the hsa-miR-15/16 family and upregulation of their targets.
circRNA target	34308761	hsa-mir-195	Uterine Cervical Neoplasms	We conclude that circ_0000228 is an oncogenic circRNA, which participates in promoting CC progression via regulating the miR
genetics_overexpression_suppress	34308752	hsa-mir-148a	Leukemia, Myeloid, Acute	CDK6 overexpression reversed the effects of miR-148a-3p on AML cells.
transcription factor target	34308746	hsa-mir-381	Sarcoma, Ewing	3p expression to inhibit apoptosis induced by ERS in HUVECs and this process was found to be mediated by caspase-4.
other	34308576	hsa-mir-221	Breast Neoplasms	MiR-221 Expression Level Correlates with Insulin-Induced Doxorubicin Resistance in MCF-7 Breast Cancer Cells.
genetics_GWAS	34308574	hsa-mir-196a-2	Colorectal Neoplasms	In the current study, we aimed to investigate association between rs11614913 polymorphism of the miRa2 gene and CRC.
other	34308569	hsa-mir-205	Melanoma	CONCLUSION: We suggested here that miR-205, -15b, -203, -9 pattern as the key miRNAs linked to melanoma status, the pluripotency, proliferation, and motility of malignant cells.
genetics_GWAS	34308291	hsa-mir-137	Schizophrenia	Compared with the PRS derived from the whole genome or the target genes of TCF4, the PRS of neuronal MIR137 -target genes explained a disproportionally larger (relative to SNP number) SZ risk in the European sample, but with a more modest advantage in the Han Chinese sample.
transcription factor target	34307695	hsa-mir-29	Carcinoma, Hepatocellular	Moreover, a new miRNA, miR3p, targeting KDM1A was found to regulate the PD-L1 expression profile in HCC cells.
genetics_overexpression_suppress	34307682	hsa-mir-101	Carcinoma, Renal Cell	RESULTS: The overexpression of miR
other	34307674	hsa-mir-451	Myocardial Ischemia	Reducing the expression of mir-451 can enhance the activity of AMPK signal pathway, and the increase of AMPK signal pathway activity is beneficial to reduce myocardial ischemia-reperfusion injury.
other	34307674	hsa-mir-451	Reperfusion Injury	Reducing the expression of mir-451 can enhance the activity of AMPK signal pathway, and the increase of AMPK signal pathway activity is beneficial to reduce myocardial ischemia-reperfusion injury.
lncRNA target	34307670	hsa-mir-103a	Carcinoma, Non-Small-Cell Lung	CONCLUSION: miR-103a-3p promotes the progression of NSCLC via Akt signaling by targeting PTEN, highlighting the role of miR-103a-3p/PTEN/Akt signaling and suggesting miR-103a-3p as a novel therapeutic target for NSCLC.
lncRNA target	34307661	hsa-mir-4741	Intervertebral Disc Degeneration	The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD.
lncRNA target	34307661	hsa-mir-663a	Intervertebral Disc Degeneration	The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD.
lncRNA target	34307661	hsa-mir-5100	Intervertebral Disc Degeneration	The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD.
exosome	34307654	hsa-mir-145	Breast Neoplasms	METHODS: Here, we exploited the exosomes from adipose tissue-derived mesenchymal stem cells (MSC-Exo) to deliver miR-145 in the T-47D breast cancer cell line.
transcription factor target	34307490	hsa-mir-140	Atherosclerosis	They have potential regulatory effects on atherosclerosis and vascular endothelial injury by targeting miR-30d-3p-TP53RK and miR3p-MKK6 axis and their downstream signaling pathways.
genetics_knock down_promote	34307457	hsa-mir-615	Prostatic Neoplasms	In addition, we observed that knockdown of miR
lncRNA target	34307388	hsa-mir-181d	Adenocarcinoma of Lung	As expected, the inhibitory effects of miR-181d-5p on LUAD cell proliferation, migration, and invasion were counteracted by restoration of C1GALT1.
lncRNA target	34307360	hsa-mir-519e	Stomach Neoplasms	All investigations indicated that Lnc_ASNR functioned as a ceRNA targeting miR-519e-5p and facilitated GC development by regulating the pathway of miR-519e-5p/FGFR2.
exosome	34307356	hsa-mir-377	Esophageal Neoplasms	Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p.
epigenetics	34307152	hsa-mir-34a	Osteosarcoma	Long Noncoding RNA DICER1-AS1 Functions in Methylation Regulation on the Multi-Drugresistance of Osteosarcoma Cells via miR-34a-5p and GADD45A.
circRNA target	34307012	hsa-mir-152	Multiple Myeloma	CONCLUSION: These results suggested that circRERE could suppress the BTZ resistance in MM cells by mediating the miR
lncRNA target	34306585	hsa-mir-890	Adenocarcinoma of Lung	Notably, SNHG3 was found to promote LUAD progression by targeting miR-890. In conclusion, the findings of the present study revealed that lncRNA SNHG3 promoted the occurrence and progression of LUAD by regulating miR-890 expression.
other	34306495	hsa-mir-210	Hypertensive  Disorder Complicating Pregnancy	CONCLUSION: miR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically.
other	34306495	hsa-mir-19a	Hypertensive  Disorder Complicating Pregnancy	CONCLUSION: miR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically.
other	34306495	hsa-mir-126	Hypertensive  Disorder Complicating Pregnancy	RESULTS: The miR-19a and miRNA-210 expressions were higher in the HDCP group, the mild preeclampsia group, and the severe preeclampsia group than they were in the normal group, and the miR-126 expression was lower (all P<0.05). The miR-19a and miRNA-210 expression levels in the severe preeclampsia group were higher than they were in the HDCP group, and the miR-126 expression was lower (P<0.05).
circulation_biomarker_prognosis_ns	34306419	hsa-mir-197	Carcinoma, Hepatocellular	RESULTS: The miR-122 and miR-197 levels in the LC tissues were lower than they were in the adjacent tissues, and they increased in the peripheral blood after chemotherapy.
circulation_biomarker_prognosis_ns	34306419	hsa-mir-122	Carcinoma, Hepatocellular	RESULTS: The miR-122 and miR-197 levels in the LC tissues were lower than they were in the adjacent tissues, and they increased in the peripheral blood after chemotherapy.
other	34306411	hsa-mir-146a	Periodontitis	CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD.
other	34306411	hsa-mir-46a	Periodontitis	CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD.
other	34306411	hsa-mir-155	Periodontitis	CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD.
circulation_biomarker_prognosis_ns	34306405	hsa-mir-20a	Stomach Neoplasms	RESULTS: miR-338 expression was low in GC patients' serum, while miR-20a was high in GC patients.
circulation_biomarker_prognosis_ns	34306405	hsa-mir-338	Stomach Neoplasms	RESULTS: miR-338 expression was low in GC patients' serum, while miR-20a was high in GC patients.
lncRNA target	34306364	hsa-mir-1285	Squamous Cell Carcinoma of Head and Neck	3p to regulate the expression of TFAP2A, promote invasion and inhibit apoptosis of HNSCC cells.
other	34306359	hsa-mir-145	Cicatrix, Hypertrophic	5p to induce the expression of TGF-beta2, and then promote the proliferation of HS fibroblasts and secretion of VEGF, which is expected to be effective in the treatment of HS.
lncRNA target	34306346	hsa-mir-889	Carcinoma, Hepatocellular	In conclusion, these findings demonstrate that circUBE2D2 accelerated the HCC glycolysis and sorafenib resistance via circUBE2D2/miR3p/LDHA axis, which provides a novel approach for HCC treatment.
target gene	34306345	hsa-mir-195	Colorectal Neoplasms	LncRNA LINC00473 promoted colorectal cancer cell proliferation and invasion by targeting miR-195 expression.
other	34306343	hsa-mir-577	Uterine Cervical Neoplasms	circMYC promotes cell proliferation, metastasis, and glycolysis in cervical cancer by up-regulating MET and sponging miR-577.
lncRNA target	34306338	hsa-mir-133b	Triple Negative Breast Neoplasms	CONCLUSION: To sum up, miR-133b can inhibit the growth and DDP resistance of TNBC cells by targeting FGFR1 and inactivating the Wnt-beta-catenin pathway.
transcription factor target	34306337	hsa-mir-192	Diabetic Nephropathies	5p expression, thus offering a new strategies and target for Urethral stricture.
circRNA target	34306334	hsa-mir-1278	Thyroid Cancer, Papillary	Our findings revealed that circNEURL4 may probably serve as a diagnostic marker to predict PTC patients' prognosis and a possible therapeutic target to PTC via miR-1278/LATS1 axis.
other	34306333	hsa-mir-3972	Stomach Neoplasms	RP11-874J12.4, a novel lncRNA, confers chemoresistance in human gastric cancer cells by sponging miR-3972 and upregulating SSR2 expression.
circulation_biomarker_diagnosis_up	34306331	hsa-mir-128	Retinoblastoma	RESULTS: ZNRD1-AS1 was up-regulated in the cytoplasm of retinoblastoma and regulated BMI1 via sponging miR
target gene	34306329	hsa-mir-625	Carcinoma, Non-Small-Cell Lung	silencing of H19 could inhibit APEX1 expression by upregulating miR-625-5p, thereby accelerating DNA damage repair in A549 cells.
lncRNA target	34306328	hsa-mir-195	Colorectal Neoplasms	These findings indicate that NEAT1 and XIST are potential prognostic factors that affect CRC onset and progression by targeting miR
circulation_biomarker_diagnosis_up	34306253	hsa-mir-181b	Heart Failure	Besides, miR-181b expressions were negatively correlated with hypersensitive C-reactive protein (hsCRP) levels in the serum of HF patients.
target gene	34306207	hsa-mir-374a	Carcinoma, Non-Small-Cell Lung	miR-374a-5p inhibits non-small cell lung cancer cell proliferation and migration via targeting NCK1.
lncRNA target	34306199	hsa-mir-124	Glioma	Based on these results, the present study concluded that miR-124 is critical for amelioration of glioma by targeting EMMPRIN, thereby acting as a tumor suppressor.
other	34306197	hsa-mir-433	Brain Injuries, Traumatic	The present study examined the expression of osteopontin (SPP1) in the tibial fracture callus and heterotopic ossification tissues in craniocerebral injury and investigated its relationship with miR-433. SPP1 mRNA and protein expression was elevated in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls By contrast, expression of miR-433 was decreased in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls.
genetics_knock down_promote	34306188	hsa-mir-3926	Arthritis, Rheumatoid	In conclusion, ZFAS1 knockdown inhibited RA-FLS proliferation, migration, invasion and inflammatory cytokine production, and induced apoptosis in RA via the miR-3926/FSTL1 axis.
transcription factor target	34306155	hsa-mir-132	Neointimal Hyperplasia	In addition, our findings revealed that CCE3 significantly increased the expression of miRNA-132, an inhibitory regulator of inflammation and restenosis, and suppressed the expression of inflammation-related molecules (inducible nitric oxide synthase, cyclooxygenase-2, interleukin- (IL-) 1beta, and IL-6).
other	34306080	hsa-mir-29b	Urinary Bladder Neoplasms	Subsequently, the expression of YB-1 and miR-29b-3p was regulated in the BC cell lines where we noted that YB-1 promoted VEGFA expression by downregulating the expression of miR- 29b-3p.
transcription factor target	34306074	hsa-mir-30	Thyroid Neoplasms	5p facilitated the TC progression through targeting FOXE1, which may offer novel therapeutic options for TC.
circulation_biomarker_diagnosis_ns	34306018	hsa-mir-631	Carcinoma, Non-Small-Cell Lung	3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC.
circulation_biomarker_diagnosis_ns	34306018	hsa-mir-590	Carcinoma, Non-Small-Cell Lung	3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC.
circulation_biomarker_diagnosis_ns	34306018	hsa-mir-492	Carcinoma, Non-Small-Cell Lung	3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC.
circulation_biomarker_diagnosis_down	34305636	hsa-mir-455	Myocardial Infarction	Conclusion: Circulating miR-1291, miR-217, miR
circulation_biomarker_diagnosis_down	34305636	hsa-mir-217	Myocardial Infarction	Conclusion: Circulating miR-1291, miR-217, miR
circulation_biomarker_diagnosis_down	34305636	hsa-mir-1291	Myocardial Infarction	Conclusion: Circulating miR-1291, miR-217, miR
target gene	34305410	hsa-mir-1224	Triple Negative Breast Neoplasms	The low TUSC7 expression is an independent prognostic factor of poor OS of TNBC patients. TUSC7 might inhibit breast cancer cell growth and metastasis both in vitro and vivo through binding with miR-1224-3P and regulating MAPK, PI3K/AKT, and NF-κB signaling pathways.
genetics_overexpression_promote	34305409	hsa-mir-497	Carcinoma, Hepatocellular	Analysis of cellular behaviors showed that overexpression of circRNA SCARB1 increased the proliferation and migration of HCC cells, while overexpression of miR-497 decreased cell proliferation and migration.
other	34305242	hsa-mir-101	Adenocarcinoma of Lung	miRNA-101 replacement therapy can be considered as an effective therapeutic strategy in non-small cell lung cancer.
transcription factor target	34305233	hsa-mir-155	COVID-19	Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05).
transcription factor target	34305233	hsa-mir-27b	COVID-19	Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05).
transcription factor target	34305233	hsa-mir-326	COVID-19	Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05).
genetics_overexpression_promote	34305100	hsa-mir-940	Osteosarcoma	Furthermore, the transfection of miR-940 mimics or SFRP1 small interfering RNA could reverse the impact of circ_0046264 overexpression on the growth, migration and invasion of osteosarcoma cells. Taken together, circ_0046264 is a tumor suppressor to inhibit the osteosarcoma progression via modulating the miR-940 / SFRP1 axis.
transcription factor target	34303763	hsa-mir-4310	Carcinoma, Hepatocellular	By suppressing SCD1-and FASN-mediated lipid synthesis, miR-4310 inhibits HCC cell proliferation, migration, and invasion in vitro and suppresses HCC tumor growth and metastasis in vivo.
transcription factor target	34303273	hsa-mir-133a	Atrial Fibrillation	CONCLUSION: H(2)S improved myocardial cell fibrosis by significantly increasing the expression of miR-133a, and CTGF might be a potential target for miR-133a to play an important role in myocardial fibrosis.
transcription factor target	34303273	hsa-mir-133a	Fibrosis, Atrial	CONCLUSION: H(2)S improved myocardial cell fibrosis by significantly increasing the expression of miR-133a, and CTGF might be a potential target for miR-133a to play an important role in myocardial fibrosis.
lncRNA target	34302879	hsa-mir-142	Neurodegenerative Diseases	5p) has been found to be dysregulated in several neurodegenerative disorders.
genetics_overexpression_promote	34302635	hsa-mir-217	Ovarian Neoplasms	Furthermore, miR-217 mimic reversed the inhibitory effect of SNHG20 overexpression on the biological behavior of ovarian cancer cells.
genetics_overexpression_suppress	34302585	hsa-let-7g	Carcinoma, Renal Cell	Expression of microRNA-301a, microRNA-23b in the clear cell renal cell carcinoma tissues was significantly overexpressed when compared with the adjacent normal tissues and let-7 g was significantly downregulated in tumor.
lncRNA target	34301920	hsa-mir-4293	Lung Neoplasms	These results provided a valuable theoretical basis for the discovery of lung carcinoma therapeutic targets and diagnostic markers based on miR-4293 and WFDC21P.
other	34301845	hsa-mir-21	Sepsis	Together, these findings demonstrate that expression of miR-21 in myeloid cells orchestrates the balance between anti-inflammatory mediators and metabolic reprogramming that drives cytokine storm during sepsis.
other	34301843	hsa-mir-10a	Colitis	Blocking the IL-10/IL-10R pathway in vivo aggravated colitis induced by miR-10a-deficient CD4(+)CD45Rb(hi) T cells.
tissue_expression_ns	34301766	hsa-mir-200	Lung Neoplasms	miR-200 deficiency in lung cancer cells promotes the proliferation and activation of adjacent cancer-associated fibroblasts (CAFs), which in turn elevates the metastatic potential of cancer cells.
genetics_GWAS	34301176	hsa-let-7i	Diabetes Mellitus, Type 2	MRNA-miRNA co-expression network and mRNA-SNP-miRNA interaction network illustrated that let-7i-5p, RASGRP3, KRT1 and CEP41 may be potential biomarkers for the early detection and diagnosis of CVD in T2DM patients. CONCLUSION: Our results suggested that downregulated let-7i-5p, and upregulated RASGRP3, KRT1 and CEP41 may play crucial roles in molecular mechanisms underlying the initiation and development of CVD in T2DM patients.
other	34301174	hsa-mir-135	Pre-Eclampsia	CONCLUSIONS: Altogether, we demonstrate that up-regulated miR-135 or reduced PCSK6 attenuates inflammatory response in PE by restricting NLRP3 inflammasome, which provides novel therapy for PE treatment.
other	34300256	hsa-mir-21	Emergence Delirium	5p, GFAP and NSP for monitoring postoperative recovery warrants further research considering their potential to predict PD and ePOCD.
transcription factor target	34299605	hsa-mir-145	Breast Neoplasms	Our data indicate a potential chemoprevention role of PEBP through the modulation of miRNA expression, particularly miR-210 and miR-145, and protection against breast cancer development and progression.
transcription factor target	34299605	hsa-mir-210	Breast Neoplasms	Our data indicate a potential chemoprevention role of PEBP through the modulation of miRNA expression, particularly miR-210 and miR-145, and protection against breast cancer development and progression.
lncRNA target	34299277	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	3p target genes (NUP205, RAN, CSE1L, SNRPD1, RPS11, SF3B1, COPA, ARCN1, and SNRNP200) had a significant impact on proliferation in 100% of the tested NSCLC cell lines in CRISPR-Cas9 (n = 78) and RNA interference (RNAi) screening (n = 92).
genetics_GWAS	34299137	hsa-mir-193a	Colorectal Neoplasms	In silico analysis of the publicly available GEO (GSE66548) dataset of KRAS-mutated versus KRAS wild-type CRC patients confirmed that miR-193a-3p was significantly downregulated in the former compared with the latter patient population. Overexpression of miR-193a-3p considerably reduced the oncogenicity of both CRC cells.
other	34299119	hsa-mir-203a	Dyslipidemias	Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Delta9-THC-exposed offspring.
other	34299119	hsa-mir-29a	Dyslipidemias	Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Delta9-THC-exposed offspring.
other	34298410	hsa-mir-375	Uterine Cervical Neoplasms	MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC.
other	34298410	hsa-mir-372	Uterine Cervical Neoplasms	MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC. MiR-30a, miR-520e, miR-548c and miR-372 were significantly associated with the overall survival of cervical SCC patients and these miRNAs were determined to be significant diagnostic markers as revealed by ROC analysis.
other	34298410	hsa-mir-143	Uterine Cervical Neoplasms	MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC.
genetics_overexpression_promote	34298254	hsa-mir-211	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Further, TCF12 was the direct target of miR-211, miR-211 bound to TCF12 mRNA 3;-untranslated region (UTR) and increased its decay, overexpression of TCF12 could effectively rescue the weakened malignant behavior of T-LBL cells caused by miR-211 overexpression.
genetics_overexpression_promote	34298200	hsa-mir-126	Diabetes Mellitus	"Finally, miR-126 overexpression confered ""diabetic"" phenotype to non-T2DM VSMCs by downregulating PI3K/AKT axis. CONCLUSIONS: miR-126 plays crucial roles in T2DM VSMC metabolic memory through activation of MEK/ERK pathway, enhancing the efficacy of Kv1.3 blockers in the prevention of restenosis in T2DM patients."
other	34298004	hsa-mir-495	Breast Neoplasms	Together, these data suggest interplay between miR3p, TGF-beta2 and FOXC1 regulating MDR in MBC and open the exploration of novel therapeutic strategies.
circulation_biomarker_prognosis_ns	34297787	hsa-mir-29a	Breast Neoplasms	miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples.
circulation_biomarker_prognosis_ns	34297787	hsa-mir-148a	Breast Neoplasms	miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples.
circulation_biomarker_prognosis_ns	34297787	hsa-mir-140	Breast Neoplasms	miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples.
genetics_overexpression_suppress	34297624	hsa-let-7f	Osteoporosis	Furthermore, inhibition of let-7f-5p or overexpression of Nme4 in BM-MSCs restored in-vivo bone formation in an ovariectomized animal model.
target gene	34297271	hsa-mir-140	Carcinoma, Hepatocellular	inhibitory role of Bie Jia Jian pill+bone mesenchymal stem cells in HCC development through regulating miR-140 and Wnt/β-catenin signal pathway.
lncRNA target	34296954	hsa-mir-493	Adenocarcinoma of Lung	5p targets RASL11B, thereby inhibiting cell growth and inducing apoptosis in LUAD.
circulation_biomarker_diagnosis_ns	34296940	hsa-mir-214	Splenic Neoplasms	5p, miR-543) had significantly different expression in serum between dogs with splenic masses (ie, hemangiosarcoma or hematoma) and serum of dogs with histologically normal spleens, with higher expression in the serum of dogs with splenic masses for all 5 miRNAs.
genetics_GWAS	34296808	hsa-mir-192	Triple Negative Breast Neoplasms	Our findings demonstrate that overexpression of epigenetically deregulated miR-192 decreases proliferation, promotes apoptosis, and inhibits migration of TNBC cell lines.
lncRNA target	34296787	hsa-mir-214	Diabetic Neuropathies	3p was delivered via tail vein injection of lentivirus.
transcription factor target	34296780	hsa-mir-26a	Osteoarthritis	SMSC-EVs carrying miR-26a-5p repaired cartilage damage of OA. CONCLUSIONS: SMSC-EVs carried miR-26a-5p into chondrocytes to up-regulate miR-26a-5p and inhibit PTEN, thereby inhibiting apoptosis and inflammation and ameliorating cartilage damage of OA.
transcription factor target	34296780	hsa-mir-26a	Cartilage Diseases	SMSC-EVs carrying miR-26a-5p repaired cartilage damage of OA. CONCLUSIONS: SMSC-EVs carried miR-26a-5p into chondrocytes to up-regulate miR-26a-5p and inhibit PTEN, thereby inhibiting apoptosis and inflammation and ameliorating cartilage damage of OA.
lncRNA target	34296550	hsa-mir-139	Leiomyoma	5p is a potential therapeutic target for leiomyoma.
genetics_overexpression_suppress	34296546	hsa-mir-34a	Ovarian Neoplasms	We found miR-34a overexpression enhanced the inhibitory effects of REV on OC cells, whereas miR-34a inhibition had the opposite effect in OC cells. CONCLUSION: Overall, these results demonstrated that REV exerts anti-cancer effects on OC cells through an miR-34a/Bcl-2 axis, highlighting the therapeutic potential of REV for treatment of OC.
lncRNA target	34296485	hsa-mir-10	Benign Paroxysmal Positional Vertigo	mori cold shock domain E1 protein) gene was predicted to be a candidate target gene for BmCPV-miR-10 with the miRNA binding site located in 3' untranslated region of its mRNA.
genetics_overexpression_promote	34296378	hsa-mir-361	Stomach Neoplasms	Mechanistically, circTMC5 overexpression promoted GC cell proliferation, invasion, and metastasis but inhibited apoptosis by sponging miR
lncRNA target	34296306	hsa-mir-638	Carcinoma, Non-Small-Cell Lung	Bioinformatics and reverse transcriptionquantitative PCR assay confirmed that miR638 was expressed at low levels in NSCLC. In summary, the present study showed that circTADA2A promoted NSCLC cell proliferation and migration via modulating miR638/KIAA0101 signaling.
genetics_knock down_promote	34296305	hsa-mir-128	Spinal Cord Injuries	Loss and gainoffunction assays were conducted in rat models of SCI to determine the roles of miR128 and ULK1 in neuronal cell apoptosis, inflammation, and motor function.
lncRNA target	34296298	hsa-mir-34a	Enterocolitis, Necrotizing	Based on the aforementioned analysis, the miR34a and SIRT1 proteins may be potential novel therapeutic targets in NEC.
other	34296287	hsa-mir-192	Hepatitis B, Chronic	The present study aimed to investigate the regulatory role of microRNA192 (miR1925p) and glucagonlike peptide1 (GLP1) in intestinal microbiota imbalance by recruiting patients with DM infected with HBV.
lncRNA target	34296286	hsa-mir-93	Acute Kidney Injury	The results of the present study suggested that the protective effect of miR93 on AKI may be associated with the activation of PTEN/AKT/mTOR pathway. miR93 may serve as a potential therapeutic target in sepsisinduced AKI.
genetics_knock down_promote	34296285	hsa-mir-7515	Pancreatic Carcinoma	The overexpression of IGF1 reversed the inhibitory effects of miR7515 overexpression on PC cells.
lncRNA target	34295819	hsa-mir-206	Carcinoma, Hepatocellular	We also found that FER was directly regulated by miR-206, and the downregulation of miR-206 was associated with proliferation and metastatic progression in HCC. CONCLUSIONS: The present research was the first to reveal that a decrease in miR-206 levels results in an increase in FER expression in HCC, leading to enhanced cell growth and metastatic abilities via activation of the NF-kappaB signaling pathway.
target gene	34295808	hsa-mir-29b	Tongue Neoplasms	CuB exerts significant anti-cancer activity by regulating expression of XIST via miR-29b.
other	34295807	hsa-mir-153	Breast Neoplasms	Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis.
circulation_biomarker_diagnosis_ns	34295803	hsa-mir-936	Stomach Neoplasms	3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs.
target gene	34295718	hsa-mir-145	Prostatic Neoplasms	Long ncRNA MALAT1 promotes cell proliferation, migration, and invasion in prostate cancer via sponging miR-145.
other	34295698	hsa-mir-497	Diabetes, Gestational	The expression of miR5p was prominently reduced in GDM patients and cell models.
lncRNA target	34295552	hsa-mir-133a	Stomach Neoplasms	However, the effect of miR-133a-5p on gastric cancer (GC) have not been uncovered. CONCLUSIONS: Our findings altogether reveal that miR-133a-5p can serve as a tumor suppressor in gastric cancer via the miR-133a-5p/TCF4 pathway.
lncRNA target	34295552	hsa-mir-133	Stomach Neoplasms	However, the effect of miR-133a-5p on gastric cancer (GC) have not been uncovered. CONCLUSIONS: Our findings altogether reveal that miR-133a-5p can serve as a tumor suppressor in gastric cancer via the miR-133a-5p/TCF4 pathway.
circulation_biomarker_diagnosis_ns	34295456	hsa-let-7a	Hodgkin Disease	Combining EV-miR3p and/or EV-let-7a-5p levels, with serum TARC (a validated protein cHL biomarker), increases the accuracy for predicting PET-status (n = 129) to an area under the curve of 0.93 (CI: 0.87-0.99), 93.5% sensitivity, 83.8/85.0% specificity and a negative predictive value of 96%.
circulation_biomarker_diagnosis_ns	34295456	hsa-mir-127	Hodgkin Disease	Combining EV-miR3p and/or EV-let-7a-5p levels, with serum TARC (a validated protein cHL biomarker), increases the accuracy for predicting PET-status (n = 129) to an area under the curve of 0.93 (CI: 0.87-0.99), 93.5% sensitivity, 83.8/85.0% specificity and a negative predictive value of 96%.
lncRNA target	34295384	hsa-mir-340	Colonic Neoplasms	5p could be used to antagonize colon cancer cell metastasis by targeting the FHL2-E-cad axis.
lncRNA target	34295265	hsa-mir-210	spondyloepimetaphyseal dysplasia, Strudwick type	Together, these data indicate that the airway epithelium-induced proliferative phenotype of ASMCs is not driven by EGFR signaling, but rather may be dependent on miR210 targeting of tumor suppressor Mnt.
genetics_knock down_suppress	34295155	hsa-mir-197	Pulmonary Disease, Chronic Obstructive	CONCLUSION: Circ-RBMS1 knockdown alleviated CSE-induced apoptosis, inflammation and oxidative stress in 16HBE cells via miR3p/FBXO11 axis, suggesting a new insight into the pathogenesis of CS-induced COPD.
transcription factor target	34294459	hsa-mir-155	Pneumonia, Staphylococcal	In conclusion, miR-155 regulates Th9 differentiation in children with MRSA by targeting SIRT1.
genetics_overexpression_promote	34294360	hsa-mir-1236	Colorectal Neoplasms	3p inhibitor could reverse the inhibition effect of circ_0101802 silencing on CRC proliferation, migration and invasion, and MACC1 overexpression also could abolish the negative regulation of miR
lncRNA target	34294143	hsa-mir-137	Bone Diseases	CONCLUSIONS: Collectively, we proposed a NOTCH1/LSD1/BMP2 co-regulatory signaling network to elucidate the modulation of miR-137 on the osteoblastic differentiation of hASCs, thus providing mechanism-based rationale for miRNA-targeted therapy of bone defect.
exosome	34294138	hsa-mir-378a	Colitis	CONCLUSION: hucMSC-derived exosomes carrying miR-378a-5p inhibited NLRP3 inflammasomes and abrogated cell pyroptosis to protect against DSS-induced colitis.
other	34294127	hsa-mir-326	Cerebral Hemorrhage	CONCLUSIONS: Our study shows that hypoxic preconditioning delays OM-MSC senescence and augments the therapeutic efficacy of OM-MSCs in ICH by upregulating the miR-326/PTBP1/PI3K-mediated autophagy.
lncRNA target	34294084	hsa-mir-411	Glioma	CONCLUSION: PSMA3-AS1 stimulated glioma progression via the miR
genetics_overexpression_promote	34294046	hsa-mir-181a	Fibrous Dysplasia of Bone	miR-181a-5p overexpression reversed the pathophysiologic features of FD BMSCs, whereas miR-181a-5p suppression induced an FD-like phenotype in normal BMSCs.
genetics_overexpression_promote	34294040	hsa-mir-182	Breast Neoplasms	5p overexpression was shown to promote tumor angiogenesis in breast cancer.
lncRNA target	34293926	hsa-mir-146a	Carcinoma, Ductal, Breast	Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%).
lncRNA target	34293926	hsa-mir-34b	Carcinoma, Ductal, Breast	Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%).
lncRNA target	34293926	hsa-mir-9	Carcinoma, Ductal, Breast	Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%).
lncRNA target	34293716	hsa-mir-149	Prostatic Neoplasms	5p/IL-6 axis may thus be a promising target for therapeutic efforts aimed at PC chemosensitization and treatment.
other	34293701	hsa-mir-1	Cardiomyopathies	Herein, a non-viral biomimetic system to directly reprogram CFs for cardiac regeneration after myocardial injury was developed by coating FH peptide-modified neutrophil-mimicking membranes on mesoporous silicon nanoparticles (MSNs) loaded with microRNA1, 133, 208, and 499 (miR Combo).
lncRNA target	34293593	hsa-mir-543	Breast Neoplasms	BC tissue samples were collected from 26 patients, and qRT-PCR and western blotting were performed to evaluate the levels of miR-543 and VCAN. We found that miR-543 inhibited BC cell viability, proliferation, migration, and invasion by repressing the expression of VCAN.
circulation_biomarker_diagnosis_ns	34293021	hsa-mir-210	Diabetic Foot	RESULTS: The HIF-1alpha expression decreased in DFU patients with increased miR-210 expression in both circulation and tissue biopsies.
genetics_knock down_promote	34292880	hsa-mir-205	Breast Neoplasms	knockdown or E2F1-overexpressing BCCs.
lncRNA target	34292663	hsa-mir-520g	Colorectal Neoplasms	Circ_0000317 represses CRC progression by targeting miR-520g and modulating HOXD10 expression.
genetics_overexpression_promote	34292652	hsa-mir-671	Thyroid Cancer, Papillary	5p overexpression on papillary thyroid carcinoma cell growth.
transcription factor target	34291866	hsa-mir-145	Glaucoma	5p inhibited the apoptosis of RGCs via TRIM2-mediated activation of the PI3K/AKT signaling pathway in NMDA-induced glaucoma.
lncRNA target	34290981	hsa-mir-637	Cholangiocarcinoma	In all, HOTTIP modulates the sensitivity to CG in CCA through the HOTTIP/miR-637/LASP1 regulatory axis, providing a new opportunities for CCA treatment.
genetics_GWAS	34290767	hsa-mir-26b	Hypertrophy, Left Ventricular	Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05).
genetics_overexpression_promote	34290668	hsa-mir-545	Thyroid Neoplasms	The overexpression of SLC7A11 or the inhibitor of miR
circulation_biomarker_diagnosis_up	34290498	hsa-mir-151a	Osteoporosis, Postmenopausal	Ovariectomized (OVX) rats were treated with antago microRNA-151a-3p or antago NC, and then serum and lumbar vertebrae were collected for ELISA and bone histomorphology analysis.
other	34290266	hsa-mir-513b	Intracranial Aneurysm	Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-miR-513b-5p, COL1A1, COL1A2, TNF-alpha, IL-6, MMP2, MMP3, MMP9 and TIMP4 in patients with ruptured IA (RA) (n = 100), patients with un-ruptured IA (UA) (n = 100), and controls (n = 100).
other	34289913	hsa-mir-146a	Chagas Disease	The relevant finding was that miR-146a was up-regulated in each sample in both phases; therefore, this miRNA could be a possible candidate biomarker in Chagas disease.
circulation_biomarker_prognosis_ns	34289890	hsa-mir-20	Lung Neoplasms	CONCLUSION: Overall our data provide a new perspective on the pro-tumorigenic role of circulating EVs in high risk smokers and highlight the significance of miR
other	34289870	hsa-mir-451a	Sarcopenia	RESULTS The SNAP-25 rs363050 AA genotype was significantly more common in sarcopenic patients compared to HC (pc=0.01); miR-451a was significantly up-regulated in these patients before rehabilitation.
target gene	34289837	hsa-mir-198	Carcinoma, Renal Cell	miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5.
lncRNA target	34289835	hsa-mir-612	Thyroid Cancer, Papillary	CONCLUSIONS: This study first demonstrates FER1L4 plays an oncogenic role in PTC via a FER1L4-miRCDH4 axis and may provide new therapeutic and diagnostic targets for PTC.
transcription factor target	34289832	hsa-mir-29a	Endometrial Neoplasms	miR-29a-3p inhibited CDC42/PAK1 signaling pathway activity in EC cells (P < 0.01).
lncRNA target	34289745	hsa-mir-141	Sepsis	CONCLUSION: MiR-141 could decrease inflammatory response and reduce myocardial cell apoptosis by targeting DAPK1, thereby playing the promising protective role in SIC.
lncRNA target	34289745	hsa-mir-141	Cardiomyopathies	CONCLUSION: MiR-141 could decrease inflammatory response and reduce myocardial cell apoptosis by targeting DAPK1, thereby playing the promising protective role in SIC.
circulation_biomarker_diagnosis_ns	34289701	hsa-mir-499	Sleep Apnea, Obstructive	Materials & methods: Plasmatic levels of miR
circulation_biomarker_diagnosis_ns	34289701	hsa-mir-499a	Sleep Apnea, Obstructive	Materials & methods: Plasmatic levels of miR
lncRNA target	34289570	hsa-mir-1258	Esophageal Squamous Cell Carcinoma	ASB16-AS1 promotes the proliferation, migration and invasion of esophageal cancer cells by targeting miR-1258.
other	34289553	hsa-mir-146b	Thyroid Cancer, Papillary	There are many markers of PTC, such as murine sarcoma viral oncogene homolog B1 (BRAF), telomerase reverse transcriptase, Ki-67, microRNA-146b, PDZ and LIM domain 5 (PDLIM5).
lncRNA target	34289449	hsa-mir-195	Triple Negative Breast Neoplasms	In conclusion, formononetin alleviated TNBC malignancy by suppressing lncRNA AFAP1-AS1-miR-195/miR-545 axis, suggesting that molecular targets combined with traditional Chinese medicine could yield significant clinical benefits in TNBC.
lncRNA target	34289449	hsa-mir-545	Triple Negative Breast Neoplasms	In conclusion, formononetin alleviated TNBC malignancy by suppressing lncRNA AFAP1-AS1-miR-195/miR-545 axis, suggesting that molecular targets combined with traditional Chinese medicine could yield significant clinical benefits in TNBC.
genetics_knock down_promote	34288826	hsa-mir-106b	Cerebral Hemorrhage, Traumatic	Over-expression of miR-106b-5p reversed the effects of H19 on cell viability and ferroptosis in BMVECs. Knockdown of H19 promoted cell proliferation and suppressed BMVECs ferroptosis by regulating the miR-106b-5p/ACSL4 axis.
circulation_biomarker_diagnosis_up	34288824	hsa-mir-488	Atherosclerosis	Serum expression of miR-488 in AS patients was higher than that in healthy controls.
genetics_overexpression_promote	34288823	hsa-mir-506	Colorectal Neoplasms	Overexpressing miR
circRNA target	34288822	hsa-mir-525	Breast Neoplasms	5p/SKA1 via the Notch and Wnt pathway, providing a potential therapeutic target for patients with OX-resistant BC.
circRNA target	34288821	hsa-mir-641	Urinary Bladder Neoplasms	Our findings indicated that circSETD3 acted as a vital tumor suppressor in BLCA via regulating the miR-641/PTEN axis.
genetics_knock down_promote	34288816	hsa-mir-502	Ovarian Neoplasms	5p-GINS2 axis was detected by assessing cell proliferation, migration, and apoptosis levels, such as caspase-3 activity and caspase-3 protein expression, in the OC cell lines CaOV3 and SKOV3, respectively.
lncRNA target	34288815	hsa-mir-429	Melanoma	To identify how circular RNA circRNA_0082835 impacts melanoma cells and lymphatic metastasis to observe whether it exerts effects through its action mechanism of sponging microRNA miR-429. In conclusion, circRNA_0082835 sponges miR-429 to affect the anti-tumor effect of miR-429 in primary melanoma and lymphatic metastasis.
genetics_knock down_suppress	34288812	hsa-mir-17	Colorectal Neoplasms	5p inhibitor could reverse the role of PAUPAR knockdown on the malignant phenotypes of CRC cells.
lncRNA target	34288804	hsa-mir-579	Squamous Cell Carcinoma of Head and Neck	Collectively, our study uncovered a functional role of circBCL11B/miR-579/LASP1 axis in OSCC, implying that targeting these molecules could be an intervention approach in OSCC treatment.
other	34288803	hsa-mir-210	Glioma	A nine-EMT-related lncRNAs (HAR1A, LINC00641, LINC00900, MIR210HG, MIR22HG, PVT1, SLC25A21-AS1, SNAI3-AS1, and SNHG18) signature was identified in patients with glioma.
other	34288803	hsa-mir-22	Glioma	A nine-EMT-related lncRNAs (HAR1A, LINC00641, LINC00900, MIR210HG, MIR22HG, PVT1, SLC25A21-AS1, SNAI3-AS1, and SNHG18) signature was identified in patients with glioma.
genetics_knock down_promote	34288800	hsa-mir-211	Pneumonia, Mycoplasma	In conclusion, the knockdown of PROX1-AS1 promoted the cell morbidity of the trophoblast cells by modulating the miR
circulation_biomarker_prognosis_ns	34288799	hsa-mir-455	Neonatal Sepsis	The expression of serum miR
other	34288535	hsa-mir-223	Hepatitis B, Chronic	3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG.
other	34288535	hsa-mir-223	Chronic Gastritis	3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG.
other	34288535	hsa-mir-483	Chronic Gastritis	3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG.
other	34288535	hsa-mir-483	Hepatitis B, Chronic	3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG.
lncRNA target	34288494	hsa-mir-181a	Colorectal Neoplasms	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
lncRNA target	34288494	hsa-mir-181a	Asthma	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
lncRNA target	34288494	hsa-mir-495	Colorectal Neoplasms	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
lncRNA target	34288494	hsa-mir-495	Asthma	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
lncRNA target	34288494	hsa-mir-33a	Colorectal Neoplasms	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
lncRNA target	34288494	hsa-mir-33a	Asthma	OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management.
other	34288395	hsa-mir-4459	Colorectal Neoplasms	5p and miR-4459 - exhibited increased levels at all CRC stages.
other	34288395	hsa-mir-1207	Colorectal Neoplasms	5p and miR-4459 - exhibited increased levels at all CRC stages.
other	34288395	hsa-mir-1225	Colorectal Neoplasms	5p and miR-4459 - exhibited increased levels at all CRC stages.
lncRNA target	34288373	hsa-mir-148a	Ovarian Neoplasms	Furthermore, we discovered that PVT1 up-regulated the expression of AGO1 and thus regulated the transforming growth factor-beta (TGF-beta) pathway to promote ovarian cancer progression through sponging miR-148a-3p. Taken together, the present study reveals that PVT1/miR-148a/AGO1 axis plays an important role in the progression of ovarian cancer and emphasize the potential as a target of value for ovarian cancer therapy.
genetics_GWAS	34288281	hsa-mir-193a	Colorectal Neoplasms	Addition of miR-193a-3p and/or modulation of proteins involved in the miR-193a-3p-mediated pathway, such as Mcl1, to EGFR/BRAF/MEK inhibition may be a potential therapeutic strategy against BRAF-mutated CRC.
genetics_knock down_promote	34288231	hsa-mir-21	Ovarian Neoplasms	5p derived from DDP-resistant SKOV3 OC cells promotes glycolysis and inhibits chemosensitivity of its progenitor SKOV3 cells by targeting PDHA1.
other	34287793	hsa-mir-183	Anovulation	96-182 cluster/FoxO1 may be a potential pathway for regulating follicular atresia and female reproduction.
lncRNA target	34287578	hsa-mir-326	Squamous Cell Carcinoma of Head and Neck	Furthermore, circDHTKD1 contributed to OSCC progression in vivo via the miR-326/GAB1 axis.
other	34287356	hsa-mir-223	Tuberous Sclerosis 1	5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade.
other	34287356	hsa-mir-142	Tuberous Sclerosis 1	5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade.
other	34287356	hsa-mir-21	Tuberous Sclerosis 1	5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade.
lncRNA target	34287099	hsa-mir-532	Carcinoma, Renal Cell	3p could attenuate the viability, migration and invasion of ccRCC cells by targeting TROAP.
lncRNA target	34287088	hsa-mir-511	Hepatic Veno-Occlusive Disease	3p aggravates HSOS by activating the Hedgehog signaling pathway through targeting Ptch1, and miR
lncRNA target	34287083	hsa-mir-7	Cataract, Congenital Zonular, with Sutural Opacities	The expression of the apoptosis marker genes in CPMs was significantly reduced after transfection with miR-7 inhibitor.
lncRNA target	34287042	hsa-mir-24	Influenza, Human	Furthermore, lncRNA IFITM4P was identified as a target of miR3p and acts as a ceRNA to inhibit the replication of IAV through regulating the mRNA levels of IFITM1, IFITM2, and IFITM3.
circulation_biomarker_diagnosis_up	34287021	hsa-mir-424	Carcinoma, Hepatocellular	Conclusions: The data suggest that serum miR-424 may represent a biomarker in early detection of HCC.
genetics_knock down_promote	34286520	hsa-mir-363	Colorectal Neoplasms	3p, and the inhibitory effect of FEZF1-AS1 knockdown on CRC progression could also be eliminated by PRRX1 overexpression.
genetics_knock down_suppress	34286518	hsa-mir-15b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Knockdown of miR-15b partially reversed cisplatin resistance in NSCLC cells through the GSK-3beta/MCL-1 pathway.
lncRNA target	34286514	hsa-mir-129	Carcinoma, Hepatocellular	CONCLUSIONS: Our findings demonstrated that PCGEM1 modulated oxaliplatin resistance by targeting the miR
lncRNA target	34286462	hsa-mir-7	Intracranial Aneurysm	CONCLUSIONS: These results suggested that ANRIL affects VSMC proliferation and apoptosis via regulation of the miR-7/FGF2 pathway in IA, which provided a potential novel strategy for the treatment of IA.
other	34286132	hsa-mir-664a	Autism Spectrum Disorder	5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients.
other	34286132	hsa-mir-197	Autism Spectrum Disorder	5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients.
other	34286132	hsa-mir-500	Autism Spectrum Disorder	5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients.
other	34286132	hsa-mir-424	Autism Spectrum Disorder	5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients.
other	34286132	hsa-mir-500a	Autism Spectrum Disorder	5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients.
circulation_biomarker_diagnosis_ns	34285721	hsa-mir-1246	Liposarcoma	The present analysis of tissue and serum miRNA expression in osteosarcoma, Ewing's sarcoma and dedifferentiated liposarcoma (DDLPS) identified miR-1246, -4532, -4454, 5p and -6126 as biomarkers for DDLPS.
other	34285579	hsa-mir-148b	Retinoblastoma	CONCLUSION: LncRNA NEAT1 can mediate miR-148b-3p/ROCK1 axis to weaken the proliferation and invasion of retinoblastoma.
therapeutic target	34285578	hsa-mir-1286	Breast Neoplasms	Silencing of circHIPK3 Sensitizes Paclitaxel-Resistant Breast Cancer Cells to Chemotherapy by Regulating HK2 Through Targeting miR-1286.
other	34285562	hsa-mir-3690	Carcinoma, Hepatocellular	CONCLUSION: We propose a risk score based on miR3p and miR-3690 that may be useful as a prognostic marker to predict HCC recurrence after LT.
other	34285562	hsa-mir-3200	Carcinoma, Hepatocellular	CONCLUSION: We propose a risk score based on miR3p and miR-3690 that may be useful as a prognostic marker to predict HCC recurrence after LT.
lncRNA target	34285545	hsa-let-7c	Urethral Stricture	CONCLUSION: These results support a role for let-7c-containing Exo-MSCs(IL-1beta) in reducing urethral stricture via inhibition of PAK1-NF-kappaB signaling, M2 macrophage polarization, and differentiation of urethral myofibroblasts.
lncRNA target	34285285	hsa-mir-486	Multiple Endocrine Neoplasia Type 1	The latter included the known suppressor miRNA miR3p, which was chosen for transfection in human adrenocortical carcinoma cell lines H295R and SW13.
lncRNA target	34285285	hsa-mir-486	Adrenocortical Carcinoma	The latter included the known suppressor miRNA miR3p, which was chosen for transfection in human adrenocortical carcinoma cell lines H295R and SW13.
circRNA target	34284793	hsa-mir-1296	Uterine Cervical Neoplasms	Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis.
other	34284726	hsa-mir-206	Osteoporosis	Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO).
other	34284726	hsa-mir-133	Osteoporosis	Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO).
other	34284726	hsa-mir-133	Obesity, Osteosarcopenic	Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO).
other	34284726	hsa-mir-206	Obesity, Osteosarcopenic	Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO).
other	34284702	hsa-mir-509	Breast Neoplasms	In this study, the association of rs73092672 which is located within the FHIT gene and the 3'UTR of hsa-miR5p with the susceptibility to breast cancer risk has been studied in the Iranian population.
circulation_biomarker_diagnosis_up	34284684	hsa-let-7a	Pre-Eclampsia	RESULTS: The relative expression of let-7a in the SPE group was significantly lower than that in the control group (0.06 /- 0.02 versus 0.25 /- 0.04, p < .05); the expression of TNF-alphamRNA in the SPE group was significantly higher than that in the control group (0.48 /- 0.04 versus 0.17 /- 0.03, p < .05); TNF-alpha protein expression was significantly increased in the SPE group (1.09 /- 0.12 versus 0.56 /- 0.03, p < .05); let-7a and TNF-alpha were significantly negatively correlated (r = -0.41, p < .05); the blood pressure and birth weight of the pregnant women in the SPE group and the control group were significantly different [systolic blood pressure (164.27 /- 4.62) mmHg versus (125.01 /- 2.23)] mmHg, diastolic blood pressure (109.24 /- 2.97) mmHg versus (75.94 /- 2.74) mmHg, neonatal birth weight (2507.02 /- 161.46) g versus (3592.12 /- 153.05) g, p < .05]; the expression of TNF-alpha in placental tissue of SPE group was significantly positively correlated with systolic and diastolic blood pressure (r = 0.93 and 0.89, p < .05).
transcription factor target	34284540	hsa-mir-125a	Brain Ischemia	These data supported the fact that miR-125a-5p silencing protects against cerebral ischemia-induced injury by targeting IGFBP3.
genetics_overexpression_promote	34284144	hsa-mir-509	Colonic Neoplasms	3-5p expression reduced in CC, and its overexpression inhibited the proliferation, migration and invasion of CC cells.
genetics_overexpression_suppress	34284141	hsa-mir-599	Urinary Bladder Neoplasms	RESULTS: MiR-599 was significantly downregulated in the BC, and miR-599 overexpression impeded the malignancy of BC cells by regulating proliferation, migration, invasion and apoptosis.
genetics_overexpression_promote	34284078	hsa-mir-376c	Stomach Neoplasms	WNT2b silencing reduced the effect of miR-376c-3p inhibition while WNT2b overexpression mitigated that of miR-376c-3p promotion on GC cell growth.
transcription factor target	34284075	hsa-mir-26b	Subarachnoid Hemorrhage	Moreover, injection of miR-26b-5p inhibitor resulted in increased MAT2A and pathway protein expression, increased inflammatory mediators, and aggravated neurological symptoms in the brain tissues of SAH rats.
transcription factor target	34284075	hsa-mir-26b	Brain Injuries	Moreover, injection of miR-26b-5p inhibitor resulted in increased MAT2A and pathway protein expression, increased inflammatory mediators, and aggravated neurological symptoms in the brain tissues of SAH rats.
transcription factor target	34283251	hsa-mir-452	Colitis	These findings suggest that MIR452 is a promising therapeutic target in the treatment of cancer and colitis.
transcription factor target	34283251	hsa-mir-452	Colorectal Neoplasms	These findings suggest that MIR452 is a promising therapeutic target in the treatment of cancer and colitis.
other	34283216	hsa-mir-96	Elephantiasis	We show that two rice genes, OsGRF4 (GROWTH REGULATING FACTOR 4) and OsGRF8 carrying in-frame mutants with disruption of the miR396 recognition sites, escape from miR396-mediated post-transcriptional silencing, resulting in enlarged grain size and increase in brown planthopper (BPH) resistance, in their respective transgenic rice lines.
transcription factor target	34283087	hsa-mir-23a	Ovarian Neoplasms, High-Grade Serous	RT-qPCR data confirmed upregulation of miR-23a-3p in tumors from chemoresistant HGSOC patients and its significant association with shorter PFS. These results highlight miR-23a-3p as a potential biomarker for HGSOC platinum response and prognosis and the miR23a-3p/APAF1 axis as a possible target to overcome platinum-resistance.
therapeutic target	34283053	hsa-mir-92b	Colorectal Neoplasms	miR-92b-3p Regulates Cell Cycle and Apoptosis by Targeting CDKN1C, Thereby Affecting the Sensitivity of Colorectal Cancer Cells to Chemotherapeutic Drugs.
lncRNA target	34282711	hsa-mir-19b	Squamous Cell Carcinoma of Head and Neck	Then, the function of the SNHG20/miR-19b-3p/RAB14 axis in OSCC was explored. LncRNA SNHG20 affects cell proliferation, migration, and invasion via the miR-19b-3p/RAB14 axis in OSCC.
other	34282692	hsa-mir-146a	Osteoarthritis	We found that CALML3-AS1 was downregulated, while miR-146a was upregulated in osteoarthritis.
lncRNA target	34282279	hsa-mir-20a	Leukemia, Myeloid, Acute	In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells. In short, curcumin suppressed the proliferation and migration, blocked the cell cycle progression of AML cells, and sensitized AML cells to Adriamycin by regulating the HOTAIR/miR-20a-5p/WT1 axis.
other	34282172	hsa-mir-151a	Non-alcoholic Fatty Liver Disease	5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis.
other	34282172	hsa-mir-4449	Non-alcoholic Fatty Liver Disease	5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis.
other	34282172	hsa-mir-21	Non-alcoholic Fatty Liver Disease	5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis.
lncRNA target	34282122	hsa-mir-451a	Lupus Erythematosus, Systemic	The findings revealed a novel mechanism linking IRF-8/miR-451a to M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development.
lncRNA target	34281839	hsa-let-7a	Colorectal Neoplasms	CONCLUSION: Let-7a inhibited the growth and metastasis of colonic mucinous adenocarcinoma cells, at least partially, by regulating the TGF-beta/Smad signaling pathway.
circulation_biomarker_prognosis_ns	34281802	hsa-mir-875	Breast Neoplasms	And serum miR-875 could screen breast cancer patients from healthy individuals.
target gene	34281530	hsa-mir-216b	Breast Neoplasms	CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis.
lncRNA target	34281459	hsa-mir-514b	Esophageal Neoplasms	Taken together, our data support the notion that lncRNA DDX11-AS1 promotes the progression of ESCA through miR-514b-3p/RBX1 axis.
epigenetics	34280597	hsa-mir-195	Osteoarthritis	5p through methylation to suppress LPS-induced apoptosis of chondrocytes, thereby suppressing OA.
circulation_biomarker_prognosis_ns	34280472	hsa-mir-425	Oropharyngeal Neoplasms	CONCLUSIONS Serum expression levels of miR
circulation_biomarker_prognosis_ns	34280472	hsa-mir-185	Xerostomia	CONCLUSIONS Serum expression levels of miR
circulation_biomarker_prognosis_ns	34280472	hsa-mir-425	Xerostomia	CONCLUSIONS Serum expression levels of miR
circulation_biomarker_prognosis_ns	34280472	hsa-mir-185	Oropharyngeal Neoplasms	CONCLUSIONS Serum expression levels of miR
circRNA target	34280452	hsa-mir-375	Hypoxia-Ischemia, Brain	3p may be a key regulatory molecule in the pineal gland following HIBD, and targeting of miR
circulation_biomarker_diagnosis_up	34279788	hsa-mir-485	Parkinson Disease	3p was significantly up-regulated in serum of PD patients compared with that in both Alzheimer's disease (AD) and healthy cases, and had diagnostic accuracy for PD screening.
exosome	34279157	hsa-mir-143	Carcinoma, Hepatocellular	RESULTS: Exosomal miR
lncRNA target	34278507	hsa-mir-26b	Breast Neoplasms	Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR26a/26b. The identification of the MALAT1/miR26a/26b/ST8SIA4 axis which contributes to breast cancer progression may constitute a potential new therapeutic target.
lncRNA target	34278507	hsa-mir-26a	Breast Neoplasms	Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR26a/26b. The identification of the MALAT1/miR26a/26b/ST8SIA4 axis which contributes to breast cancer progression may constitute a potential new therapeutic target.
genetics_knock down_suppress	34278506	hsa-mir-367	Prostatic Neoplasms	The overexpression of miR3673p or the knockdown of Rab23 inhibited the proliferation, invasion, and metastasis of prostate cancer cells.
lncRNA target	34278505	hsa-mir-106b	Carcinoma, Non-Small-Cell Lung	The aforementioned results indicated that TMEM100 induced cell apoptosis and inhibited cell survival by serving as a tumour suppressor and that miR106bmitigatedTMEM100 expression defined a potentially oncogenic pathway in NSCLC.
genetics_knock down_promote	34278482	hsa-mir-485	Carcinoma, Endometrioid	The tumor suppressing effect of LINC01224knockdown on EC progression was partly rescued by treatment with miR4855p inhibitor.
other	34278472	hsa-mir-613	Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, X-Linked	However, the mechanism underlying the miR36133pmediated apoptosis of HSexposed endothelial cells remains unclear. In conclusion, the miR36133p/MAP3K2/p38/caspase3 pathway may serve an indispensable role in regulating the progression of apoptosis, indicating a regulatory role of miR36133p in the pathophysiology of HSexposed endothelial cells.
lncRNA target	34278471	hsa-mir-29a	Norrie disease	Furthermore, SPARC could induce the formation of EMT in 16HBE cells in vitro and this was directly targeted by miR29a3p and mediated by pERK, suggesting that miR29a3p may participate in the airway remodeling of NA.
genetics_overexpression_promote	34278459	hsa-mir-135b	Multiple Myeloma	Overexpressing DANCR or knocking down miR135b5p reduced the viability of the MM cells, as well as restrained MM cells from migrating and invading.
genetics_overexpression_promote	34278448	hsa-mir-25	Glioblastoma	By contrast, miR253p overexpression facilitated the proliferation and TMZ resistance of sensitive GBM cells.
genetics_knock down_promote	34278445	hsa-mir-221	Glioma	The present study aimed to verify the activity on glioblastoma cancer cell lines of one of the most active compounds tested, corresponding to 2(3', 4', 5'trimethoxyanilino)3cyano/alkoxycarbonyl6substitu 5,6,7tetrahydrothiene[2,3c] pyridine (compound 3b), used in combination with an antimiR2213p PNA, already demonstrated to be able to induce high levels of apoptosis. To the best of our knowledge, the results obtained herein demonstrate for the first time a 'combination therapy' performed by the combined use of a PNA targeting miR221 and the tetrahydrothiene[2,3c]pyridine derivative 3b, supporting the concept that the combined treatment of GBM cells with a PNA against a specific upregulated oncomiRNA (in the present study a PNA targeting miR2213p was used) and antitubulin agents (in the present study derivative 3b was used) is an encouraging strategy which may be used to enhance the efficacy of anticancer therapies and at the same time, to reduce sideeffects.
genetics_overexpression_promote	34278444	hsa-mir-431	Nasopharyngeal Carcinoma	Overexpression of PBOV1 neutralized the miR431mediated suppression of NPC progression.
circulation_biomarker_prognosis_ns	34277865	hsa-mir-15b	Leukemia, Lymphocytic, Chronic, B-Cell	The expression levels of miR-15b and miR-195 were significantly higher in the plasma of patients with B-CLL compared to the healthy individuals (91.6, p= 0.001) (169, p= 0.001). CONCLUSION: Both miR-15b and miR-195, have the potential to function as novel and non-invasive biomarkers in the diagnosis and prognosis of patients with B-CLL.
circulation_biomarker_prognosis_ns	34277865	hsa-mir-195	Leukemia, Lymphocytic, Chronic, B-Cell	The expression levels of miR-15b and miR-195 were significantly higher in the plasma of patients with B-CLL compared to the healthy individuals (91.6, p= 0.001) (169, p= 0.001). CONCLUSION: Both miR-15b and miR-195, have the potential to function as novel and non-invasive biomarkers in the diagnosis and prognosis of patients with B-CLL.
target gene	34277808	hsa-mir-218	Breast Neoplasms	Tumor protein D52 promotes breast cancer proliferation and migration via the long non-coding RNA NEAT1/microRNA-218-5p axis.
genetics_overexpression_promote	34277805	hsa-mir-21	Atherosclerosis	CONCLUSIONS: In summary, LncRNA-TCONS_00034812 is upregulated in atherosclerotic samples, and its overexpression upregulates miR-21 through methylation in human aortic smooth muscle cells (HAOSMCs).
target gene	34277782	hsa-let-7c	Lung Neoplasms	Lin28A promotes the proliferation and stemness of lung cancer cells via the activation of mitogen-activated protein kinase pathway dependent on microRNA let-7c.
other	34277765	hsa-mir-205	Diabetes Mellitus	RESULTS: In the hippocampus of STZ-treated diabetic rats, lncRNA Vof-16, and Gnb3 mRNA were significantly upregulated and silicon analysis showed that Vof-16 and miR-205 share the same miRNA response element (MRE).
circulation_biomarker_diagnosis_down	34277703	hsa-mir-124	Ischemic Stroke	3p in EVs was negatively correlated with serum pro-inflammatory cytokines and the NIHSS (p < 0.05).
other	34277699	hsa-mir-497	Intervertebral disc disease	5p level was negatively proportional to HOXC13-AS expression in IDD specimens.
other	34277644	hsa-mir-10b	Breast Neoplasms	First, the miRNAs, miR-135, miR-203, miR-10b, miR-194, miR-886, and miR-124 were evaluated in bone metastatic tissues, relative to adjacent control tissue. miR-203 was significantly down-regulated while miR-10b was significantly up-regulated in bone metastasis.
other	34277644	hsa-mir-194	Breast Neoplasms	Additionally, miR-135 was significantly differentially expressed in the primary lung cancer patients while miR-194 in primary breast cancer patients.
other	34277644	hsa-mir-135	Breast Neoplasms	Additionally, miR-135 was significantly differentially expressed in the primary lung cancer patients while miR-194 in primary breast cancer patients.
other	34277644	hsa-mir-203	Breast Neoplasms	First, the miRNAs, miR-135, miR-203, miR-10b, miR-194, miR-886, and miR-124 were evaluated in bone metastatic tissues, relative to adjacent control tissue. miR-203 was significantly down-regulated while miR-10b was significantly up-regulated in bone metastasis.
other	34277611	hsa-mir-495	Intervertebral disc disease	CONCLUSION: Our findings identified a novel circSNHG5-miR3p axis responsible for IDD progression.
other	34277608	hsa-mir-223	Inflammation	This study provided a regulation axis, EGF/miR-223/ISG15, and illustrated its regulation to gMEC apoptosis and inflammation.
transcription factor target	34277606	hsa-mir-17	Esophageal Neoplasms	Notably, the gene most frequently associated with increased risk was HNRNPA2B1; in ESCA, the increased expression of this gene alone predicted poor prognosis by affecting tumor-promoting signaling pathways through miR
exosome	34277601	hsa-mir-630	Ovarian Neoplasms	Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630.
other	34277600	hsa-mir-940	Sarcoma	Afterward, we constructed an immune infiltration-related risk score model based on the expression of IRF1, MFNG, hsa-miR-940, and hsa-miR-378a-5p, presenting a promising performance in predicting the prognosis of patients with sarcoma.
other	34277600	hsa-mir-378a	Sarcoma	Afterward, we constructed an immune infiltration-related risk score model based on the expression of IRF1, MFNG, hsa-miR-940, and hsa-miR-378a-5p, presenting a promising performance in predicting the prognosis of patients with sarcoma.
target gene	34277424	hsa-mir-135b	Esophageal Neoplasms	Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
lncRNA target	34277412	hsa-mir-195	Adenocarcinoma of Lung	In summary, this work elucidates that LINC00665 accelerates LUAD progression via the miR5p/MYCBP axis by acting as a competing endogenous RNA (ceRNA), suggesting that LINC00665 may represent a potential therapeutic target for clinical intervention of LUAD.
lncRNA target	34277403	hsa-mir-326	Prostatic Neoplasms	The current results demonstrate that PCAT6 acted as a tumor activator in PCa progression by sponging miR-326 and increasing Hnrnpa2b1 expression and that the PCAT6/miR-326/Hnrnpa2b1 signaling might be a new therapeutic target for PCa.
target gene	34277059	hsa-mir-155	lung squamous cell carcinoma	MicroRNA-155-5p promotes cell proliferation and invasion in lung squamous cell carcinoma through negative regulation of fibroblast growth factor 9 expression.
genetics_GWAS	34276910	hsa-mir-542	Hemophilia A	3p target the F8 gene and suppress the expression of FVIII protein, which may contribute to the development of HA without F8 mutations.
genetics_GWAS	34276910	hsa-mir-5581	Hemophilia A	3p target the F8 gene and suppress the expression of FVIII protein, which may contribute to the development of HA without F8 mutations.
lncRNA target	34276213	hsa-mir-30	Glioma	miR-330 inhibition restored the malignancy of glioma cells. CONCLUSION: This study demonstrated that GABPB1-AS1 competitively bound to miR-330 and de-repressed ZNF367 expression, leading to activation of the cell cycle signaling pathway and the growth and metastasis of glioma cells.
other	34275894	hsa-mir-6089	Lymphoma, B-Cell, Diffuse	CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis.
other	34275894	hsa-mir-3960	Lymphoma, B-Cell, Diffuse	CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis.
other	34275894	hsa-mir-939	Lymphoma, B-Cell, Diffuse	CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis.
lncRNA target	34274947	hsa-mir-138	Stomach Neoplasms	Furthermore, rescue assay further confirmed that UBE2CP3 mainly promoted GC progression through miR
genetics_overexpression_promote	34274936	hsa-mir-181b	Eosinophilic enteropathy	RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls).
other	34274936	hsa-mir-146a	Eosinophilic enteropathy	We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls.
other	34274936	hsa-mir-370	Gastritis, Atrophic	We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls.
genetics_overexpression_promote	34274936	hsa-mir-490	Eosinophilic enteropathy	RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls).
genetics_overexpression_promote	34274936	hsa-mir-21	Eosinophilic enteropathy	RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls).
other	34274936	hsa-mir-370	Eosinophilic enteropathy	We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls.
other	34274936	hsa-mir-146a	Gastritis, Atrophic	We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls.
genetics_overexpression_promote	34274936	hsa-mir-181	Eosinophilic enteropathy	RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls).
other	34274912	hsa-mir-613	Pancreatic Carcinoma	METHODS The expressions of CircCCT3 and miR-613 in pancreatic carcinoma tissues and cell lines were evaluated by quantitative real-time polymerase chain reaction (PCR).
genetics_overexpression_promote	34274651	hsa-mir-383	Melanoma	5p overexpression inhibited the proliferation, migration, and invasion of M14 and A375 cells.
genetics_overexpression_promote	34274607	hsa-mir-1224	Carcinoma, Renal Cell	3p, and overexpression of circ-EGLN3 reversed the repressive effects of miR
lncRNA target	34274471	hsa-let-7a	Breast Neoplasms	Our results showed that the inhibition of NANOG combined with Let-7a restoration contributed to significant decrease in malignant phenotypes and stemness feature of BC cells.
lncRNA target	34274194	hsa-mir-155	Oral Submucous Fibrosis	CONCLUSION: Taken together, these findings indicate that miR-155 is implicated in the pathogenesis of oxidative stress-associated OSF, possibly through the regulation of RPTOR.
lncRNA target	34273985	hsa-mir-376c	Holoprosencephaly 7	BACKGROUND: Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis.
lncRNA target	34273985	hsa-mir-376c	Thyroid Cancer, Papillary	BACKGROUND: Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis.
transcription factor target	34273914	hsa-mir-4661	Stomach Neoplasms	5p led to an increase in the expression of KDM5D while a decline in the expression of Mars2, which reduced the malignant behaviors of GC cells; however, the malignant behaviors of GC cells was restored after further inhibition of KDM5D.
circulation_biomarker_diagnosis_ns	34273912	hsa-mir-143	Mouth Neoplasms	We explored these potential melanoma-specific exosomal miRNAs further and found that miR-143 and let-7b increased in primary, whereas miR-210, 708, 221, and 222 increased in metastatic site originated melanoma cells. Further analysis showed miR-143 and 221 significantly increased in plasma exosomes of metastatic melanoma patients.
lncRNA target	34273844	hsa-mir-493	Ischemic Stroke	Conclusion MEG3 inhibits NSC proliferation of after IS via positive regulation of miR
lncRNA target	34273804	hsa-mir-335	Esophageal Squamous Cell Carcinoma	In short, THAP9-AS1 accelerated cell growth of ESCC through sponging miR
circulation_biomarker_prognosis_ns	34273216	hsa-mir-491	Squamous Cell Carcinoma of Head and Neck	5p prediction model could serve as a blood-based diagnostic marker for LA-HNSCC.
transcription factor target	34273068	hsa-mir-222	Carcinoma, Hepatocellular	Our findings suggest that miR3p might be a potential diagnostic and therapeutic target for HCC and HBV-related HCC.
other	34272987	hsa-mir-642a	Cardiomyopathies	In this study we aimed to evaluate the effect of miR-642a on sepsis-induced cardiac injury in vitro and explore the possible lncRNA-microRNA mechanism.
other	34272987	hsa-mir-642a	Myocardial Injury	In this study we aimed to evaluate the effect of miR-642a on sepsis-induced cardiac injury in vitro and explore the possible lncRNA-microRNA mechanism.
genetics_overexpression_promote	34272655	hsa-mir-575	Glioma	In addition, the overexpression of miR-575 promoted the proliferation, migration, and invasion of glioma cells.
lncRNA target	34272387	hsa-mir-200c	Breast Neoplasms	Therefore, MIR200CHG can promote the proliferation, invasion, and drug resistance of breast cancer by interacting with and stabilizing YB-1, and has the potential to become a target for breast cancer treatment.
circulation_biomarker_prognosis_ns	34272079	hsa-mir-21	Sepsis	CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises.
circulation_biomarker_prognosis_ns	34272079	hsa-mir-210	Sepsis	CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises.
circulation_biomarker_prognosis_ns	34272079	hsa-mir-210	Burns	CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises.
circulation_biomarker_prognosis_ns	34272079	hsa-mir-21	Burns	CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises.
circRNA target	34271943	hsa-mir-195	Osteosarcoma	CONCLUSIONS: Circ_001422 accelerates OS tumorigenesis and metastasis by modulating the miR5p/FGF2/PI3K/Akt axis, implying that circ_001422 can be therapeutically targeted to treat OS.
other	34271919	hsa-mir-195	Prostatic Neoplasms	CONCLUSIONS: Taken together, our findings revealed a novel regulatory mechanism between circDPP4 and miR-195/cyclin D1 axis, and offered novel strategies for the treatment of PCa.
genetics_overexpression_promote	34271873	hsa-mir-148a	Small Cell Lung Carcinoma	In SCLC cells, MCM3AP-AS1 overexpression increased ROCK1 and promoted cancer cell invasion and migration, while miR-148a overexpression showed the opposite effects and attenuated the effects of MCM3AP-AS1 overexpression on ROCK1 expression and cell behaviors. CONCLUSIONS: MCM3AP-AS1 sponges miR-148a, thereby increasing SCLC cell invasion and migration via upregulating ROCK1 expression.
circulation_biomarker_diagnosis_up	34271014	hsa-mir-138	Sepsis	METHODS: Serums of 22 patients with sepsis-induced myocardial injury (SIMI) and 24 healthy controls were collected to determine the expression levels of ZFAS1 and miR
other	34271004	hsa-mir-143	Hepatitis C	We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4).
other	34271004	hsa-mir-181a	Hepatitis C	We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4).
other	34271004	hsa-mir-204	Hepatitis C	We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4).
other	34271004	hsa-mir-93	Hepatitis C	We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4).
other	34271004	hsa-mir-122	Hepatitis C	We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4).
lncRNA target	34270989	hsa-mir-199a	Diabetes Mellitus	In conclusion, our data demonstrated that miR-199a-3p/DDR1/p53/p21 signaling pathway was involved in endothelial senescence under diabetic conditions, and therapeutic targeting DDR1 would be exploited to inhibit endothelial senescence owing to high glucose exposure.
exosome	34270841	hsa-mir-1246	Cardiomegaly	Our purpose here was to examine the relevance of exosomal microRNA-1246 (miR-1246) released from human umbilical cord mesenchymal stem cell (hucMSC) during CHF and the mechanism of action.
circRNA target	34270834	hsa-mir-762	Pneumonia, Mycoplasma	CONCLUSION: In all, circ_0011460 suppressed HTR8/SVneo cell growth, migration, and invasion via miR-762/HTRA1 axis, suggesting a new insight into the pathogenesis of PE.
circulation_biomarker_prognosis_up	34270831	hsa-mir-21	Colorectal Neoplasms	Furthermore, plasma miR21-5p can predict recurrence and PD after surgical resection.
transcription factor target	34270823	hsa-mir-181c	GATA2 Deficiency	These findings indicate that miR-181c expression is increased and MCL1 levels decreased in GATA2 deficiency cells, and that GATA2 represses miR-181c transcription. Increased miR-181c may contribute to elevated cell death and cytopenia in GATA2 deficiency potentially through down-regulation of MCL1.
transcription factor target	34270823	hsa-mir-181c	Hematologic Diseases	Increased miR-181c may contribute to elevated cell death and cytopenia in GATA2 deficiency potentially through down-regulation of MCL1.
other	34270733	hsa-mir-185	Adenocarcinoma of Lung	In summary, our results show that LINC00205 contributes to LUAD malignancy by sponging miR5p, which provides new insight into LUAD progression.
genetics_knock down_promote	34270708	hsa-mir-339	Muscular Dystrophy, Duchenne	Finally, knockdown of miR
lncRNA target	34270000	hsa-mir-517a	Diabetes, Gestational	The data suggested that lncRNA-SNX17 might promote the trophoblast proliferation through miR-517a/IGF-1 pathway and might play a role in the placentation of diabetic macrosomia.
transcription factor target	34269814	hsa-mir-138	Retinal Diseases	CONCLUSIONS: SAL protected against hypoxia-induced HRMECs injury through regulating miR-138/ROBO4 axis, indicating the protective potential of SAL in retinopathies.
circRNA target	34269702	hsa-mir-599	Angelman Syndrome	In conclusion, circ-USP9X silencing decreased ox-LDL-induced endothelial cell injury via the miR-599/CLIC4 axis, which offered a novel molecular mechanism to comprehend the pathology of AS.
transcription factor target	34269482	hsa-mir-140	Neuralgia	3p/JAG1 to alleviate NP.
genetics_overexpression_promote	34269397	hsa-mir-361	Diabetic Nephropathies	Intriguingly, overexpression of DAPK1 in HG-stimulated podocytes muted miR
other	34269309	hsa-mir-1290	Breast Neoplasms	Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction.
other	34269309	hsa-mir-16-1	Breast Neoplasms	Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction.
other	34269309	hsa-mir-662	Breast Neoplasms	Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction.
other	34269309	hsa-mir-29c	Breast Neoplasms	Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction.
other	34269309	hsa-mir-146a	Breast Neoplasms	Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction.
lncRNA target	34269220	hsa-mir-29	Ischemic Stroke	The inhibition of miR-29b expression decreased the neurological function score and reduced the cerebral infarction volume and cell apoptosis.
transcription factor target	34269220	hsa-mir-29b	Ischemic Stroke	These findings suggest that the inhibition of miR-29b inhibits oxidative stress and cell apoptosis in ischemic stroke, producing therapeutic effects in ischemic stroke.
circRNA target	34269180	hsa-mir-370	Glioblastoma	In conclusion, circCLSPN elicited an oncogenic role in tumorigenesis and malignant progression of human GBM cells through circCLSPN-miR3p-USP39 pathway.
genetics_knock down_suppress	34269081	hsa-mir-204	Carcinoma, Non-Small-Cell Lung	3p inhibitor could reverse the inhibitory effect of LINC00958 knockdown on proliferation and migration of NSCLC cells.
lncRNA target	34269003	hsa-mir-335	Breast Neoplasms	The Editors of JBUON issue an Expression of Concern to 'MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2', by Yajue Wang, Feng Wen; JBUON 2020;25(2):666-674; PMID: 32521851.
lncRNA target	34269002	hsa-mir-22	Glioma	The Editors of JBUON issue an Expression of Concern to 'MicroRNA-22 regulates the proliferation, drug sensitivity and metastasis of human glioma cells by targeting SNAIL1', by Yunqiang Zhang, Lijun Tu, Xiuhong Zhou, Bin Li; JBUON 2020;25(1):491-496; PMID: 32277674.
lncRNA target	34268979	hsa-mir-214	Pancreatic Carcinoma	CONCLUSION: In conclusion, the expression of miR-214 is highly expressed in pancreatic cancer tissues, and the down-regulation of ING4 protein expression can inhibit the proliferation, invasion and migration of pancreatic cancer cells, promote their apoptosis, and can be used as a new molecular target for the diagnosis and treatment of pancreatic cancer.
lncRNA target	34268963	hsa-mir-613	Glioma	CONCLUSION: LncRNA MALAT1 can promote the proliferation and invasion of glioma cells and inhibit the apoptosis of glioma cells by sponging miR-613.
other	34268958	hsa-mir-24	Prostatic Neoplasms	3p.
genetics_overexpression_promote	34268937	hsa-mir-183	Laryngeal Neoplasms	CONCLUSIONS: The overexpression of miR-183 can inhibit the drug resistance of the human primary laryngeal cancer cells to 5-Fu, promote cancer cell apoptosis and inhibit their invasive and migratory abilities at the same time, whose mechanism may be associated with the targeted regulation of the TBX3/PTEN signaling pathway by miR-183.
lncRNA target	34268933	hsa-mir-206	Mouth Neoplasms	CONCLUSIONS: HOTTIP promotes the tumor proliferation activity and migration of oral cancer cells through modulating miR-206.
lncRNA target	34268922	hsa-mir-7	Ovarian Neoplasms	CONCLUSIONS: CircHIPK3 has an obviously increased expression level in the carcinoma tissues of ovarian cancer patients, and the inhibition of circHIPK3 can activate the miR
genetics_overexpression_promote	34268920	hsa-mir-186	Uterine Cervical Neoplasms	Overexpression of microRNA
other	34268918	hsa-mir-139	Ovarian Neoplasms	5p and FGF-2 contributes to the diagnosis and treatment of OC, and is an available biomarker for the diagnosis and prognosis of patients.
other	34268792	hsa-mir-551b	Thyroid Cancer, Papillary	3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features.
other	34268792	hsa-mir-1301	Thyroid Cancer, Papillary	3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features.
other	34268792	hsa-mir-455	Thyroid Cancer, Papillary	3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features.
other	34268792	hsa-mir-1296	Thyroid Cancer, Papillary	3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features.
other	34268792	hsa-mir-532	Thyroid Cancer, Papillary	3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features.
other	34268484	hsa-mir-21	Ischemic And   Traumatic Injuries	In the present review, we discuss the role of miR-21 in acute CNS injuries which is currently thought to be a potent neuroprotective microRNA.
other	34268410	hsa-let-7a	Stomach Neoplasms	3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution.
other	34268410	hsa-mir-135b	Stomach Neoplasms	3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution.
other	34268410	hsa-mir-455	Stomach Neoplasms	3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution.
circRNA target	34268375	hsa-mir-1827	Glioma	The downregulation of circ_0080229 inhibited gliomas in vivo and suppressed U87 and U251 cell lines in vitro, which the transfection of the miR-1827 inhibitor could reverse.
transcription factor target	34268365	hsa-mir-21	Spinal Cord Ischemia	5p, its target genes (MAP2K3 and PPP1R3B), and related signaling pathways.
other	34268360	hsa-mir-183	Colorectal Neoplasms	By using cox proportional hazard models, we then developed 6-miRNA-classifier (miR-183, -20a, -21, -195, -139 and -20a) to predict prognosis in clinical cohort, that had significantly superior predictive performance compared to other clinicopathological factors, and could successfully identify high-risk stage II and III CRC patients with poor prognosis [hazard ratio (HR) =2.16; P=0.0048].
other	34268360	hsa-mir-183	Stomach Neoplasms	By using cox proportional hazard models, we then developed 6-miRNA-classifier (miR-183, -20a, -21, -195, -139 and -20a) to predict prognosis in clinical cohort, that had significantly superior predictive performance compared to other clinicopathological factors, and could successfully identify high-risk stage II and III CRC patients with poor prognosis [hazard ratio (HR) =2.16; P=0.0048].
genetics_overexpression_promote	34268117	hsa-mir-338	Nasopharyngeal Carcinoma	5p overexpression on NPC development were reversed by upregulating WNT2B.
genetics_overexpression_promote	34267819	hsa-mir-106a	spinal cord glioma	In addition, overexpression of CELF-2 in spinal cord glioma cells reversed the tumor-promoting effects of miR-106a-5p both in vitro and in vivo.
target gene	34267818	hsa-mir-203	Pancreatic Neoplasms	MicroRNA-203-3p inhibits the proliferation, invasion and migration of pancreatic cancer cells by downregulating fibroblast growth factor 2.
other	34267816	hsa-mir-377	Liver Neoplasms	lncRNA LOXL1-AS1 promotes liver cancer cell proliferation and migration by regulating the miR-377-3p/NFIB axis.
target gene	34267814	hsa-mir-181a	Stomach Neoplasms	miR-181a-5p, inhibited the proliferation of drug-resistant cells and enhanced their sensitivity to DDP.
other	34267778	hsa-mir-96	Pancreatic Carcinoma	Only mimi-surv found miR-96, a previously unidentified PDAC-related miRNA in these two real datasets.
other	34267554	hsa-mir-567	Squamous Cell Carcinoma of Head and Neck	The lncRNA also promoted OSCC cell proliferation by directly binding to miR-567, leading to an increase in CDK8 expression.
other	34267179	hsa-mir-195	Diabetic Retinopathy	However, the function and mechanism of miR-195 in EMT and cell permeability in diabetic retinopathy remain largely unclear.
lncRNA target	34267173	hsa-mir-181b	Inflammation	Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats.
lncRNA target	34267173	hsa-mir-181b	Cerebral Hemorrhage	Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats.
lncRNA target	34267173	hsa-mir-181b	Brain Ischemia	Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats.
circulation_biomarker_diagnosis_ns	34266857	hsa-mir-21	Adenomatous Polyposis Coli	Finally, the reported data suggest miRNA-21 could serve as a predictive serum biomarker for polyposis burden in patients with FAP.
lncRNA target	34266696	hsa-mir-612	Melanoma	The oncogenic role of the LINC01116/miR-3612/GDF11/SDC3 axis in melanoma was finally demonstrated. CONCLUSION: Conclusively, LINC01116 sequestered miR-3612 and targeted GDF11 and SDC3 to contribute to the progression of melanoma.
lncRNA target	34266379	hsa-mir-144	Lung Abscess	This study was designed to explore the therapeutic effects of Propofol, both in vivo and in vitro, on lung I/R injury and the underlying mechanisms related to metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/microRNA-144 (miR-144)/glycogen synthase kinase-3beta (GSK3beta). CONCLUSION: Overall, our study demonstrated that Propofol played a protective role in lung I/R injury by suppressing autophagy and decreasing release of inflammatory factors, with the possible involvement of the MALAT1/miR-144/GSK3beta axis.
lncRNA target	34266345	hsa-mir-25	Carcinoma, Non-Small-Cell Lung	3p/PTEN/PI3K/AKT axis might accelerate DDP tolerance in NSCLC, which may serve as a potential target for chemotherapy resistance in NSCLC.
genetics_overexpression_promote	34266334	hsa-mir-18a	Pulmonary Disease, Chronic Obstructive	Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. Overexpression of CASC2 might inhibit the bronchial epithelial cell apoptosis and inflammation via targeting miR-18a-5p/IGF1 axis.The reviews of this paper are available via the supplemental material section.
other	34266326	hsa-mir-21	Carcinoma, Hepatocellular	CONCLUSIONS: miR-21 is a valuable biomarker for the early diagnosis of HCC.
circulation_biomarker_diagnosis_up	34265390	hsa-mir-874	Ischemic Stroke	3p and IL1B levels in serum of patients with IS were measured.
other	34264867	hsa-mir-182	Obesity	5p-induced signaling pathway in adipose tissue may be an effective approach to ameliorate obesity and associated metabolic diseases.
other	34264867	hsa-mir-182	Metabolic Diseases	Activation of the miR5p-induced signaling pathway in adipose tissue may be an effective approach to ameliorate obesity and associated metabolic diseases.
circulation_biomarker_prognosis_ns	34264524	hsa-mir-10b	Breast Neoplasms	Therefore, we aimed to investigate the circulating levels of miR-10b and its target soluble E- cadherin as potentially easily accessible biomarkers for breast cancer. CONCLUSION: Our data suggest that circulating miR-10b could be utilized as a potential non-invasive serum biomarker for diagnosis and prognosis of breast cancer with better performance to predict BC metastasis achieved on measuring it simultaneously with serum sE-cadherin.
lncRNA target	34264003	hsa-mir-103a	Adenocarcinoma of Lung	CONCLUSIONS: SVIL-AS1 inhibited chemoresistance by acting as a sponge for miR-103a and upregulating ICE1 expression, which may be a potential therapeutic target for chemotherapy in LUAD.
transcription factor target	34263708	hsa-mir-15b	COVID-19	Our findings provide evidence that hsa-miR15b-5p may suppresses viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp.
other	34263426	hsa-mir-128	Glioma	3p/ITGA5 axis was involved in glioma initiation and progression, and might offer a potential novel strategy for treatment of glioma.
exosome	34262466	hsa-mir-99a	Tuberous Sclerosis	Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease.
exosome	34262466	hsa-mir-212	Tuberous Sclerosis	Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease.
exosome	34262466	hsa-mir-212a	Tuberous Sclerosis	Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease.
other	34262342	hsa-mir-758	Uterine Cervical Neoplasms	Circular RNA Circ_0003221 Promotes Cervical Cancer Progression by Regulating miR-758-3p/CPEB4 Axis.
other	34262334	hsa-mir-576	Ischemic Stroke	In addition, we identified miR3p as having the most regulatory roles in both T2DM and ischemic stroke.
other	34262334	hsa-mir-576	Diabetes Mellitus	In addition, we identified miR3p as having the most regulatory roles in both T2DM and ischemic stroke.
other	34262312	hsa-mir-574	Diabetic Nephropathies	5p.
exosome	34261453	hsa-mir-34c	Cholangiocarcinoma	BACKGROUND: This study aimed to investigate the exact regulatory mechanisms of exosomal miR-34c in mediating communication between cholangiocarcinoma cells and fibroblasts. Additionally, cancer-associated fibroblasts (CAFs) activated by downregulation of exosomal miR-34c promoted cholangiocarcinoma progression.
transcription factor target	34260911	hsa-mir-29c	Leukemia	A negative correlation of miR-29c and RAG1 levels is also observed in leukemia patients, suggesting the potential use of miR-29c as a biomarker and a therapeutic target.
other	34260396	hsa-let-7b	Inflammation	aeruginosa lung infections are associated with a hyperinflammatory state, treatment with let-7b-5p and a beta-lactam antibiotic in nanoparticles or EVs may benefit patients with antibiotic-resistant P.
other	34260071	hsa-mir-4301	Rotavirus Infections	To investigate the role of miR-4301 in rotavirus (RV)-infected Caco-2 cells.
lncRNA target	34259681	hsa-mir-138	Triple Negative Breast Neoplasms	Moreover, on elucidating the molecular mechanism, we found that CDHP-4@PP-NPs could exhibit apoptotic, anti-migratory, as well as anti-stemness activity against TNBC cell lines through the downregulation of miR-138. Our recent study, hence for the first time, unravels the synthesis of CDHP-4@PP-NPs and the molecular mechanism behind the anti-migration, anti-stemness and anti-tumor efficacy of the nanoparticles against the TNBC cells through the miR-138/p65/TUSC2 axis.
lncRNA target	34259142	hsa-mir-200c	Pancreatic Carcinoma	Further experiments revealed that down-regulation of miR-200c-3p expression reversed the inhibitory effect of lowly expressed circPUM1 on PC cells.
circulation_biomarker_diagnosis_ns	34259105	hsa-mir-6515	Thromboangiitis Obliterans	5p.Conclusions: Our findings imply that circulating exosomal miR
circulation_biomarker_prognosis_ns	34258959	hsa-mir-21	Lymphoma, Large B-Cell, Diffuse	CONCLUSIONS: The study suggested that plasma miR-21 might be a valuable non-invasive prognostic marker of response to treatment in DLBCL patients.
genetics_knock down_promote	34258391	hsa-mir-145	Urinary Bladder Neoplasms	Circular RNA VANGL1 knockdown suppressed viability, promoted apoptosis, and increased doxorubicin sensitivity through targeting miR-145-5p to regulate SOX4 in bladder cancer cells.
genetics_knock down_suppress	34258298	hsa-mir-382	Uterine Cervical Neoplasms	5p knockdown on cervical cancer cells.
lncRNA target	34258297	hsa-mir-497	Endometrial Neoplasms	CONCLUSION: This study illustrates that circSLC6A6 plays a role in promoting EC progression via the miR5p-mediated PI4KB/hedgehog pathway.
circRNA target	34258296	hsa-mir-136	Lung Neoplasms	Mechanistically, in lung cancer and using bioinformatics, we demonstrated that circ_0044516 sponges miR-136 targeting MAT2A.
other	34258170	hsa-mir-1269a	Carcinoma, Hepatocellular	Two novel regulatory pathways, EGOT-miR5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/ axis, were built up and contribute to the underlying mechanism of HCC pathogenesis.
other	34258170	hsa-mir-193b	Carcinoma, Hepatocellular	Two novel regulatory pathways, EGOT-miR5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/ axis, were built up and contribute to the underlying mechanism of HCC pathogenesis.
target gene	34258104	hsa-mir-140	Neuroblastoma	Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells.
lncRNA target	34257820	hsa-mir-199b	Diabetic Nephropathies	These results demonstrate that hsa-miR-199b-3p improves E-cadherin expression and prevents the progression of DN through targeting KDM6A. miR-199b-3p could be a future biomarker or target for the diagnosis or treatment of DN.
target gene	34257725	hsa-mir-148a	Uterine Cervical Neoplasms	MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1.
circulation_biomarker_diagnosis_up	34257722	hsa-mir-10b	Adenocarcinoma of Lung	In conclusion, EV-associated miR-10b may be a potential diagnostic biomarker for LUAD that is superior to plasma miR-10b and TMs.
genetics_overexpression_promote	34257708	hsa-mir-221	Myocardial Reperfusion Injury	5p showed an opposite trend to that of ADAM8 overexpression.
lncRNA target	34257707	hsa-mir-2355	Triple Negative Breast Neoplasms	In addition, chromobox 5 (CBX5) was identified to be targeted by miR
lncRNA target	34257670	hsa-mir-375	Oral Submucous Fibrosis	Functional rescue experiments were further performed to verify the role of the miR-375/FOXF1 axis in OSF. We highlighted that ADSC-EVs inhibited fBMF fibrosis and then suppressed OSF progression via the miR-375/FOXF1 axis.
target gene	34257656	hsa-mir-326	Stomach Neoplasms	LncRNA SNHG3 Promotes Gastric Cancer Cells Proliferation, Migration, and Invasion by Targeting miR-326.
genetics_overexpression_suppress	34257650	hsa-mir-466	Carcinoma, Hepatocellular	The results showed that miR-466 was significantly downregulated in HCC tissues and cell lines, and inhibited proliferation, invasion, and high apoptosis were found in HCC cells when miR-466 was overexpressed.
other	34257616	hsa-mir-543	Pars Planitis	MicroRNAs (miRNAs) are reported to be master regulators in a variety of diseases, including IUA, but the role of microRNA-543 (miR-543) in IUA remains to be elucidated.
genetics_knock down_promote	34257576	hsa-mir-491	Lung Neoplasms	5p restored the MALAT1 knockdown-induced inhibition of the progression of lung carcinoma.
circRNA target	34257535	hsa-mir-1243	Squamous Cell Carcinoma of Head and Neck	Collectively, the current study demonstrated that circ_0043265 was downmodulated in TSCC and was identified as a ceRNA that restrained the cell proliferation, migration and invasion of SCC25 and Cal27 cells via modulating the miR-1243/SALL1 axis.
genetics_overexpression_suppress	34257520	hsa-mir-450a-2	Cardiomyopathies	3p overexpression and improves cardiac fibrosis in patients with atrial fibrillation.
genetics_overexpression_suppress	34257520	hsa-mir-450a-2	Atrial Fibrillation	3p overexpression and improves cardiac fibrosis in patients with atrial fibrillation.
exosome	34257272	hsa-mir-92a	Retinoblastoma	Specifically, our data showed that miR-92a-3p was enriched in RB exosomes. Thus, our work suggests that exosomal miR-92a-3p is involved in tumor angiogenesis and might be a promising therapeutic candidate for retinoblastoma.
circRNA target	34257163	hsa-mir-365a	Neurodegenerative Diseases	Collectively, our results show that the circRNA FUT10/miR365a-3p/HOXA9 axis is a promising therapeutic target and are expected to facilitate the development of therapeutic strategies to improve the prognosis of degenerative muscle disease.
lncRNA target	34257080	hsa-mir-24	Gerodermia osteodysplastica	5p expression via c-Myc, an oncogenic transcription factor in cancer cells.
genetics_GWAS	34257080	hsa-mir-24	Adenocarcinoma of Lung	Finally, we provide evidence that TP53 mutations coupled with high miR5p expression predict poor prognosis in patients with lung adenocarcinoma.
genetics_GWAS	34257080	hsa-mir-24	Carcinoma, Non-Small-Cell Lung	We report that miR5p is upregulated in human cancer cell lines and non-small cell lung carcinoma (NSCLC) tumors carrying TP53 GOF mutations.
exosome	34256859	hsa-mir-100	Hypocalciuric hypercalcemia, familial, type 1	5p expression rescued the reduction in osteogenesis and angiogenesis caused by the NONFH exosomes by activating the BMPR2/SMAD1/5/9 signalling pathway.
exosome	34256859	hsa-mir-100	Femur Head Necrosis	CONCLUSION: The NONFH exosomal miR5p can lead to NONFH-like damage by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway, which may be involved in the pathophysiological mechanisms of nontraumatic osteonecrosis of the femoral head (NONFH).
other	34256840	hsa-mir-126	COVID-19	3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization.
other	34256840	hsa-mir-17	COVID-19	3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization.
other	34256840	hsa-mir-29a	COVID-19	3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization.
other	34256840	hsa-mir-1	COVID-19	3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization.
other	34256802	hsa-mir-126	Cardiomegaly	CONCLUSIONS: AA supplementation upregulated the expression of miR-126 and conferred cardio-protection effect against AngII induced cardiac hypertrophy.
other	34256802	hsa-mir-126	Diabetic Nephropathies	CONCLUSIONS: AA supplementation upregulated the expression of miR-126 and conferred cardio-protection effect against AngII induced cardiac hypertrophy.
genetics_overexpression_promote	34256796	hsa-mir-126	Carcinoma, Endometrioid	Moreover, overexpression of MCM3AP-AS1 and VEGF increased the migration and invasion rates of EC cells, while overexpression of miR-126 suppressed these cell behaviors.
genetics_overexpression_promote	34256371	hsa-mir-192	Alzheimer Disease	Overexpression of miR
genetics_overexpression_promote	34256086	hsa-mir-135a	Meningitis, Bacterial	METHODS: In vitro BBB models were developed by co-culturing hCMEC/D3 cells with glioma cells, whereupon the glioma-exposed endothelial cells (GECs) were treated with a series of mimics, inhibitors, overexpression plasmids, and shRNAs for evaluating whether NEAT1, microRNA-135a (miR-135a) and hypoxia-inducible factor 1alpha (HIF1alpha) mediated BBB integrity and permeability.
other	34255836	hsa-mir-135b	Pancreatic Carcinoma	Our results support the identification of miR135b from the original study as a potential biomarker of PDAC and identify other potentially stronger miRNA biomarkers of PDAC.
lncRNA target	34255617	hsa-mir-613	Nasopharyngeal Carcinoma	Taken all together, these findings highlight FAM225B as an oncogene that promotes NPC proliferation and metastasis through miR-613/CCND2 axis.
other	34255383	hsa-mir-10b	Infertility	5p)-mRNAs interaction network.
other	34255383	hsa-mir-99a	Infertility	5p)-mRNAs interaction network.
other	34255383	hsa-mir-26a	Infertility	5p)-mRNAs interaction network.
other	34255383	hsa-mir-151	Infertility	5p)-mRNAs interaction network.
other	34255190	hsa-mir-485	Cicatrix, Hypertrophic	5p and thereby activates TGF-beta1/Smad signaling pathway, promoting the abnormal proliferation of fibroblasts and excessive deposition of ECM in hypertrophic scar formation.
other	34254987	hsa-mir-146a	Glaucoma	TRANSITIONAL RELEVANCE: The IOP-lowering effects of miR-146 observed in rats provides a necessary step toward the development of an effective gene therapy for glaucoma in humans.
other	34254987	hsa-mir-146	Glaucoma	TRANSITIONAL RELEVANCE: The IOP-lowering effects of miR-146 observed in rats provides a necessary step toward the development of an effective gene therapy for glaucoma in humans.
genetics_knock down_promote	34254950	hsa-mir-877	Esophageal Squamous Cell Carcinoma	In conclusion, our results indicated the oncogenic role of linc00941 in ESCC, and knockdown of linc00941 suppressed ESCC cell proliferation, invasion, migration and EMT via interacting with miR
lncRNA target	34254931	hsa-mir-197	Carcinoma, Non-Small-Cell Lung	Survival analysis data showed that the low expression of hsa_circ_0026337 was significantly associated with shortened survival time in NSCLC (P = 0.037), which increased the expression level of hsa-miR3p, thereby inhibiting the translation of specific proteins.
other	34254931	hsa-mir-1252	Carcinoma, Non-Small-Cell Lung	3p and miR-558, respectively.
other	34254931	hsa-mir-494	Carcinoma, Non-Small-Cell Lung	3p and miR-558, respectively.
other	34254931	hsa-mir-558	Carcinoma, Non-Small-Cell Lung	3p and miR-558, respectively.
lncRNA target	34254728	hsa-mir-3529	Adenocarcinoma of Lung	Overall, FOXA1-induced LINC01287 serves as a competing endogenous RNA to promote proliferation and inhibit apoptosis of LUAD cells via upregulation of RNASEH2A expression at the posttranscriptional level by competitively combining with miR
transcription factor target	34254638	hsa-mir-100	Atherosclerosis	This study demonstrates that hUCMSC-Ex-miR5p inhibits cell progression and inflammatory response in eosinophils via the FZD5/Wnt/beta-catenin pathway, thereby alleviating atherosclerosis progression.
lncRNA target	34254453	hsa-mir-21	Lung Neoplasms	5p mimic damaged the inhibitory effect of SMAD7.
circulation_biomarker_diagnosis_ns	34254354	hsa-mir-221	Arthritis, Rheumatoid	3p can colocate in the nucleus and cytoplasm in RA-FLSs.
lncRNA target	34254279	hsa-mir-218	cervical squamous cell carcinoma	Circ-ATAD1 is upregulated in CSCC and may regulate cell proliferation and apoptosis by suppressing the maturation of miR-218.
genetics_knock down_suppress	34253241	hsa-mir-599	Colorectal Neoplasms	ONECUT2 overexpression recovered the effects of miR-599 on CRC malignant behaviors.
transcription factor target	34253194	hsa-mir-186	Uterine Cervical Neoplasms	IGF1 could restore the inhibitory effects of miR
lncRNA target	34253104	hsa-mir-5006	Adenocarcinoma of Lung	5p/FZD1 axis might serve as a potential biomarker and therapeutic target for LUAD treatment.
lncRNA target	34252882	hsa-mir-20a	Glioma	We constructed a circCCDC66 regulating miRNA network and revealed miR-320a was a potential target of circCCDC66, which was down-regulated in high-grade gliomas compared to low-grade gliomas. CONCLUSIONS: CircCCDC66 could facilitate glioma cells proliferation, invasion and migration by down-regulating miR-320a and up-regulating FOXM1.
other	34252537	hsa-mir-15a	Intervertebral Disc Degeneration	This study aimed to understand the interactions and impact of miR-15a and NP-MSCs on chondrogenic differentiation and IVD degeneration.
other	34252537	hsa-mir-15a	Substance Abuse, Intravenous	This study aimed to understand the interactions and impact of miR-15a and NP-MSCs on chondrogenic differentiation and IVD degeneration.
lncRNA target	34252535	hsa-mir-92a	Podocyte Hypertrophy	Exogenous IL-6 stimulation up-regulated IL-6/STAT3 signaling and miR-92a-3p, reduced P57 expression and promoted podocyte proliferation, apoptosis and hypertrophy in vitro. Taken together, these results suggested that high fructose possibly increased KHK-A expression to down-regulate TTP, subsequently activated IL-6/STAT3 signaling to interfere with podocyte proliferation and apoptosis by up-regulating miR-92a-3p to suppress P57 expression, causing podocyte hypertrophy.
exosome	34252490	hsa-mir-150	Enterovirus A Infection	To excavate the key circRNAs in EV-A71 infection, we comprehensively evaluated and integrated the relationship of circRNA/miRNA/mRNA, and eventually screened 2 key circRNA regulatory axes, namely hsa_circ_0017115/hsa-miR
lncRNA target	34251977	hsa-mir-762	Acute Lung Injury	CONCLUSION: miR-762 is implicated in the pathogenesis of LPS-induced ALI via modulating inflammation and oxidative stress, which depends on its regulation of SIRT7 expression.
transcription factor target	34251959	hsa-mir-532	Brain Ischemia	LOC366613 participates in cerebral I/R injury by regulating the miR5p/PTEN axis, potentially providing a new CI treatment target.
genetics_knock down_promote	34251586	hsa-mir-296	Atherosclerosis	CONCLUSION: Taken together, circRNA_102541 was upregulated in atherosclerosis, and knockdown of circRNA_102541 suppressed cell proliferation while promoted apoptosis of HUVEC cells via miR
other	34250246	hsa-mir-137	Ovarian Neoplasms	HULC was significantly upregulated and miR-137 was downregulated in PTX-resistant OC tissues and cells. Collectively, HULC modulated ITGB8 expression to promote PTX resistance of OC by sponging miR-137.
other	34250088	hsa-mir-140	Ovarian Neoplasms	5p to activate the PI3K/AKT signaling pathway and promote the proliferation, invasion, migration and EMT of OC.
circRNA target	34250012	hsa-mir-106a	Sepsis	Therefore, we concluded that circTLK1 contributed to sepsis-associated AKI by regulating inflammation and oxidative stress through the miR-106a-5p/HMGB1 axis. CircTLK1 and miR-106a-5p may be employed as the potential targets for the treatment of AKI.
exosome	34249964	hsa-mir-181a	Colitis	This indicated that MSC exosomal miR-181a may exhibit potential as a disease-modifying drug for UC.
exosome	34249964	hsa-mir-181	Colitis	This indicated that MSC exosomal miR-181a may exhibit potential as a disease-modifying drug for UC.
exosome	34249903	hsa-mir-892b	Breast Neoplasms	Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.
lncRNA target	34249735	hsa-mir-204	Urinary Bladder Neoplasms	We also found that NRP1 was a predicted target of miR-204, miR-143, miR-145, and miR-195 in BC development.
lncRNA target	34249735	hsa-mir-143	Urinary Bladder Neoplasms	We also found that NRP1 was a predicted target of miR-204, miR-143, miR-145, and miR-195 in BC development.
genetics_overexpression_promote	34249713	hsa-mir-183	Colonic Neoplasms	Overexpressing THEM4 abated miR
lncRNA target	34249610	hsa-mir-133a	Intervertebral Disc Degeneration	The inhibition of miR-133a-5p ameliorated the acceleration of IVDD induced by the silence of FBXO6 in vitro.
target gene	34249593	hsa-mir-199	Lung Neoplasms	MicroRNA-199-3p targets Sp1 transcription factor to regulate proliferation and epithelial to mesenchymal transition of human lung cancer cells.
exosome	34249474	hsa-mir-1983	Glioma	Herein, we demonstrate the existence of an innate anti-glioma NK-mediated circuit initiated by glioma-released miR-1983 within exosomes, and which is under the regulation of galectin-1 (Gal-1).
lncRNA target	34249465	hsa-mir-195	Breast Neoplasms	MiR-195 is a tumor suppressive microRNA in breast cancer.
other	34249465	hsa-mir-19	Breast Neoplasms	Low miR-195 expressing tumors were associated with enhanced glycolysis and poor survival in ER-positive tumors, but not other subtypes of breast cancer. In conclusion, low expression of miR-195 in ER-positive breast cancer was associated with enhanced cancer cell proliferation, glycolysis, and worse overall survival.
transcription factor target	34249436	hsa-mir-23a	Esophageal Squamous Cell Carcinoma	Our findings describe a role for HP1BP3 in promoting tumor growth and metastasis by upregulating miR-23a to target TRAF5 in esophageal cancer.
other	34249429	hsa-mir-19b	Prostatic Neoplasms	MiR-19b-3p and miR-101-3p as potential biomarkers for prostate cancer diagnosis and prognosis.
other	34249429	hsa-mir-101	Prostatic Neoplasms	MiR-19b-3p and miR-101-3p as potential biomarkers for prostate cancer diagnosis and prognosis.
transcription factor target	34249133	hsa-mir-20a	Parkinson Disease	These findings demonstrate that miR-20a-5p contributes to MPP(+)-induced mitochondrial disruption and cell damage, and miR-20a-5p might be a novel therapeutic target for PD.
other	34249125	hsa-mir-373	Thyroid Cancer, Papillary	In conclusion, CREB3 activated lncRNA ZFAS1 at the transcriptional level to promote PTC metastasis by modulating miR3p/MMP3.
circRNA target	34249089	hsa-mir-590	Myocardial Infarction	Circ_0124644 silencing could alleviate hypoxia-induced cardiomyocytes injury by regulating the miR3p/SOX4 axis, suggesting that it might be a target for alleviating AMI.
other	34249085	hsa-mir-361	Rectal Neoplasms	In conclusion, lncRNA SNHG17 functions as an oncogenic lncRNA in rectal cancer by regulating the miR3p/STC2 axis.
lncRNA target	34249000	hsa-mir-139	Acquired Immunodeficiency Syndrome	5p inhibitor-transfected pEVs from HIV ART-naive and on-ART patients expressed reduced levels of miR
lncRNA target	34248630	hsa-mir-27a	Cardiomegaly	Taken together, our results revealed miR-27a-3p/Hoxa10/Kv4.3 axis as a new mechanism of Ang II-induced cardiomyocyte hypertrophy, which provided a new target for clinical prevention and treatment of cardiac hypertrophy and heart failure.
other	34248121	hsa-mir-185	ST Elevation Myocardial Infarction	Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling.
other	34248121	hsa-mir-185	Myocardial Infarction	Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling.
other	34247992	hsa-mir-153	Diabetic Nephropathies	3p was lower in diabetic nephropathy patients, while the expression of PAQR3 was concomitantly higher.
genetics_knock down_promote	34247598	hsa-mir-526b	Melanoma	Further, the inhibitory effects of NCK1-AS1 knockdown on cell proliferation and migration in melanoma were reversed by the depletion of miR-526b-5p and further counteracted by ADAM15 knockdown.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-135a	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-222	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-23a	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-130a	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-145a	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-221	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_diagnosis_up	34247489	hsa-mir-199a	peripartum cardiomyopathy	3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis.
circulation_biomarker_prognosis_up	34247370	hsa-mir-106a	Carcinoma, Renal Cell	High serum expression of miR-106a is an independent predictor for tumor TNM stage and lymph node metastasis, as well as an independent predictor for poor prognosis of RCC patients.
transcription factor target	34247369	hsa-mir-548m	Orofacial Cleft	Inhibiting of the expression of the MIR548M gene in oral epithelial celllines has resulted in up-regulation of the expression of SUMO1 gene which was known to involve in the pathogenesis of orofacial cleft. CONCLUSION: Dosage insufficiency of the MIR548M gene may underlie the etiology of orofacial cleft in this fetus.
transcription factor target	34247316	hsa-mir-431	Stomach Neoplasms	The HIF-1alpha/HYPAL/miR5p/CDK14 (Cyclin-dependent kinase 14) axis activated the Wnt/beta-catenin signaling pathway and induced GC cell proliferation while inhibiting apoptosis.
circulation_biomarker_diagnosis_up	34247256	hsa-mir-548a	Graft vs Host Disease	The expressions of plasma miR
circulation_biomarker_diagnosis_up	34247256	hsa-mir-5787	Graft vs Host Disease	The expressions of plasma miR
circulation_biomarker_diagnosis_up	34247256	hsa-mir-455	Graft vs Host Disease	The expressions of plasma miR
genetics_overexpression_promote	34246986	hsa-mir-138	Melanoma	Our data shows that the overexpression of miR
other	34246852	hsa-mir-340	Glioma	METHODS AND MATERIALS: RT-qPCR was performed to evaluate the expression levels of LINC00662, miR5p in glioma tissues and cell lines.
lncRNA target	34246727	hsa-let-7e	Polycystic Ovary Syndrome	Let-7e may thus be a potential therapeutic target in non-HA PCOS.
lncRNA target	34246626	hsa-mir-19a	Sepsis	In conclusion, miR-19a-3p may suppress DIC by targeting TF and might be a potential therapeutic target in treating sepsis-induced DIC.
lncRNA target	34246626	hsa-mir-19a	Disseminated Intravascular Coagulation	In conclusion, miR-19a-3p may suppress DIC by targeting TF and might be a potential therapeutic target in treating sepsis-induced DIC.
circulation_biomarker_diagnosis_up	34246297	hsa-mir-142	Gout	3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals.
circulation_biomarker_diagnosis_up	34246297	hsa-mir-17	Gout	3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals.
circulation_biomarker_diagnosis_up	34246297	hsa-mir-18a	Gout	3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals.
circulation_biomarker_diagnosis_up	34246297	hsa-mir-223	Gout	3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals.
genetics_knock down_suppress	34245111	hsa-mir-621	Stomach Neoplasms	Dual-luciferase reporter gene assay showed that miR-621 could bind circ_0000064 and SYF2 3'UTR; in addition, miR-621 overexpression or SYF2 knockdown could partially weaken the cancer-promoting effect of circ_0000064 on GC cells.
exosome	34244990	hsa-mir-627	Carcinoma, Non-Small-Cell Lung	3p/Smads signaling pathway by transferring exosomes to THP-1 cells.
genetics_overexpression_promote	34244973	hsa-mir-202	Uterine Cervical Neoplasms	In conclusion, the overexpression of miR
other	34244572	hsa-mir-378a	psoriasis 1	Here, we reported a significant up-regulation of miR-378a-3p (miR-378a) in skin biopsies from active psoriatic lesions while it was down-regulated after treatment with methotrexate or narrow-band ultraviolet B phototherapy. These findings offer a mechanistic model where miR-378a contributes to the pathogenesis of psoriasis.
lncRNA target	34244473	hsa-mir-214	Carcinoma, Renal Cell	5p/E2F2 axis, and lncRNA RCAT1 might be a novel prognostic biomarker and a potential therapeutic target for renal cell carcinoma.
other	34244338	hsa-mir-378f	Ischemic Stroke	Validation using qRT-PCR showed that miR-378f and miR-450b-5p were significantly elevated among the cardioembolic thrombi; both microRNAs were inversely correlated with the ejection fraction from echocardiography.
other	34244338	hsa-mir-93	Ischemic Stroke	5p than those from neurologically stable patients.
other	34244338	hsa-mir-629	Ischemic Stroke	5p than those from neurologically stable patients.
other	34244338	hsa-mir-450b	Ischemic Stroke	Validation using qRT-PCR showed that miR-378f and miR-450b-5p were significantly elevated among the cardioembolic thrombi; both microRNAs were inversely correlated with the ejection fraction from echocardiography.
other	34243729	hsa-mir-200c	Pulmonary Disease, Chronic Obstructive	MiR-200c-3p expression was significantly decreased in lung tissues from COPD patients compared to that in healthy controls.
circulation_biomarker_diagnosis_ns	34243103	hsa-mir-146a	Multiple Sclerosis, Relapsing-Remitting	RESULTS: Plasma levels of miR-34a (p<0.001) and miR-125a-5p (p=0.034) were higher, whereas miR-146a-5p levels were lower (p=0.041) in RRMS patients compared to CTRs.
circulation_biomarker_diagnosis_ns	34243103	hsa-mir-125a	Multiple Sclerosis, Relapsing-Remitting	RESULTS: Plasma levels of miR-34a (p<0.001) and miR-125a-5p (p=0.034) were higher, whereas miR-146a-5p levels were lower (p=0.041) in RRMS patients compared to CTRs.
other	34243103	hsa-mir-34a	Multiple Sclerosis, Relapsing-Remitting	The aim of this study was to evaluate the expression of selected inflamma-miRs, i.e., miR-34a-5p, -125a-5p, -146a-5p, and -155, in relapsing-remitting multiple sclerosis (RRMS) and their modulation after treatment with dimethyl fumarate (DMF).
circulation_biomarker_diagnosis_ns	34242639	hsa-mir-126	Renal Insufficiency, Chronic	CONCLUSIONS: We found baseline serum miR-126 levels were associated with changes in eGFR and new CKD cases in a five-year prospective study.
lncRNA target	34241734	hsa-mir-172b	Dehydration	This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses.
lncRNA target	34241734	hsa-mir-398a	Dehydration	This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses.
lncRNA target	34241734	hsa-mir-156d	Dehydration	This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses.
other	34241580	hsa-mir-381	Melanoma	Importantly, we further confirmed that ZBED3-AS1 promoted the malignant progression of melanoma by regulating miR3p/ARID4B axis to activate the phosphatidylinositol 3-kinase/AKT serine/threonine kinase (PI3K/AKT) signalling pathway.
genetics_knock down_suppress	34240756	hsa-mir-204	Acute Kidney Injury	After transfection, CCK-8, flow cytometry, and TUNEL staining assays were performed to evaluate the effects of MALAT1 and miR-204 on AKI progression. CONCLUSIONS: Collectively, these results illustrated that knockdown of lncRNA MALAT1 could ameliorate AKI progression and inflammation by targeting miR-204 through APOL1/NF-kappaB signaling.
transcription factor target	34240406	hsa-mir-335	Melanoma	5p expression with consequent downregulation of GJB5, one of its targets.
transcription factor target	34240323	hsa-mir-206	Cholangiocarcinoma	CONCLUSION: Altogether, our findings clarified that miR-206 inhibited CCA malignancy by negatively regulating JARID2.
other	34240204	hsa-mir-509	Uterine Cervical Neoplasms	CONCLUSIONS: HOXA-AS2 accelerates cellular progression in cervical cancer by the miR3p/BTN3A1 axis.
lncRNA target	34240166	hsa-mir-6875	Abortion, Habitual	5p is involved in RSA by decreasing the differentiation of pDCs via inhibition of the STAT3/E2-2 signaling pathway.
lncRNA target	34240140	hsa-mir-222	Adenocarcinoma of Lung	Importantly, miR-222 expression decreased cell viability, phenocopying the tumor suppressor role of SMARCA4-SWI/SNF complexes in LUAD.
genetics_overexpression_suppress	34239888	hsa-mir-199a	Cholangiocarcinoma	Functionally, the silence of SNHG12 inhibited the proliferation and metastasis of ICC cells, while miR-199a-5p overexpression exhibited an opposite result.
lncRNA target	34239873	hsa-mir-194	Carcinoma, Hepatocellular	CONCLUSION: CircUBAP2 plays a significant role in promoting HCC via the miR
genetics_overexpression_promote	34239673	hsa-mir-27a	Endometrial Neoplasms	USP46 expression was downregulated in EC cell lines during miR-27a overexpression.
genetics_overexpression_promote	34239606	hsa-mir-522	Myocardial Infarction	TNRC6A regulates cell viability and apoptosis of cardiomyocytes after MI, and TNRC6A-induced MI can be reversed by overexpression of miR
exosome	34239562	hsa-mir-22	Colorectal Neoplasms	Exosomes miR-22-3p Derived from Mesenchymal Stem Cells Suppress Colorectal Cancer Cell Proliferation and Invasion by Regulating RAP2B and PI3K/AKT Pathway.
lncRNA target	34239561	hsa-mir-215	Breast Neoplasms	Moreover, miRNAs selection tools predicted that miR-215 and mir5p which have a tumor suppressor role in BC can be targeted by our candidate circRNAs to affect the PI3K/AKT pathway; in conclusion, further studies are required to validate the oncogene role of our candidate circRNAs through the PI3k pathway.
lncRNA target	34239561	hsa-mir-383	Breast Neoplasms	Moreover, miRNAs selection tools predicted that miR-215 and mir5p which have a tumor suppressor role in BC can be targeted by our candidate circRNAs to affect the PI3K/AKT pathway; in conclusion, further studies are required to validate the oncogene role of our candidate circRNAs through the PI3k pathway.
other	34239351	hsa-mir-2355	Carcinoma, Hepatocellular	Finally, a candidate regulatory microRNA, miR5p, for PYCR1 mRNA was discovered in HCC.
genetics_knock down_suppress	34239305	hsa-mir-140	Breast Neoplasms	Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p.
transcription factor target	34239303	hsa-mir-567	Alzheimer Disease	In the current study, the improvement effects of rTMS on MCI associated with AD were explored by focusing on miR-567/NEUROD2/PSD95 axis. CONCLUSION: The findings outlined in the current study demonstrated that rTMS treatment could protect brain against AD-induced MCI without significant side effects, and the function depended on the inhibition of miR-567.
lncRNA target	34239033	hsa-mir-27a	Sepsis	Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
lncRNA target	34239033	hsa-mir-27a	Lung Injury	Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
other	34239017	hsa-mir-29a	Stomach Neoplasms	Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients.
exosome	34238918	hsa-mir-7641	Breast Neoplasms	Carcinoma associated fibroblasts small extracellular vesicles with low miR-7641 promotes breast cancer stemness and glycolysis by HIF-1α.
genetics_knock down_promote	34238737	hsa-mir-4719	Breast Neoplasms	ARHGAP36 overexpression significantly reversed the inhibitory effects of miR-4719 mimics on migration and invasion of breast cancer cells (P < 0.05).
circulation_biomarker_diagnosis_down	34238731	hsa-mir-483	Ovarian Insufficiency, Premature	Detection of serum miR
circulation_biomarker_diagnosis_up	34238666	hsa-let-7	Colonic Neoplasms	The colon cancer cell lines were treated with plasmids or oligonucleotides to alter NEAT1, BACH1 and let-7 g-5p expression.
other	34238665	hsa-mir-454	Carcinoma, Hepatocellular	3p) and discs large homolog 5 (DLG5) was determined in tissues samples from the recruited patients with HCC.
genetics_overexpression_suppress	34238324	hsa-mir-585	Ovarian Neoplasms, High-Grade Serous	Overexpression of CAPN9 reduced the inhibitory effect of miR
target gene	34238300	hsa-mir-146	Urinary Bladder Neoplasms	LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146.
lncRNA target	34238213	hsa-mir-145	Stomach Neoplasms	CONCLUSIONS UCA1 accelerated cell proliferation and inhibited cell apoptosis through sponging miR-145 to upregulate MYO6 expression in gastric cancer, indicating that the UCA1/miR-145/MYO6 axis may serve as a potential therapeutic target for gastric cancer.
genetics_knock down_promote	34238206	hsa-mir-182	Angelman Syndrome	5p overexpression and RASA1 knockdown reversed the effects of circMTO1 overexpression on the proliferation, migration, and apoptosis of ox-LDL-stimulated VSMCs.
genetics_overexpression_promote	34238196	hsa-mir-125b	Colonic Neoplasms	Overexpression of miR-125b inhibited proliferation and promoted apoptosis in SW480 colon cancer cells and was accompanied by upregulated Bax expression and downregulated Bcl-2 expression (P<0.05).
circulation_biomarker_prognosis_up	34238179	hsa-mir-133a	Breast Neoplasms	CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients.
circulation_biomarker_prognosis_up	34238179	hsa-mir-21	Breast Neoplasms	CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients.
circulation_biomarker_prognosis_up	34238179	hsa-mir-205	Breast Neoplasms	CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients.
circulation_biomarker_prognosis_up	34238179	hsa-mir-155	Breast Neoplasms	CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients.
lncRNA target	34238170	hsa-mir-27b	Stomach Neoplasms	CONCLUSION: MiR-27b-3p was down-regulated in GC, and it could regulate Hippo pathway and affect EMT by inhibiting RUNX1 expression.
genetics_GWAS	34238140	hsa-mir-193	Triple Negative Breast Neoplasms	At the epigenetic level, TNBC is characterized by epigenetic signatures, such as DNA methylation, histone remodeling, and a host of miRNA, MiR-193, LncRNA, HIF- 2alpha, eEF2K, LIN9/NEK2, IMP3, LISCH7/TGF-beta1, GD3s, KLK12, mediated regulation.
genetics_overexpression_promote	34238129	hsa-mir-145	Prostatic Neoplasms	PLD5 overexpression exerted a cancerous effect while mimicking of miR
lncRNA target	34237985	hsa-mir-138	Neuralgia	Western blotting showed that the protein expressions of MIP-1alpha and CCR1 in pSNL miRNA138 mimic group were significantly decreased on day 7. CONCLUSIONS: Intrathecal injection of miRNA-138 can remarkably alleviate NP in rats with a pSNL, which may be achieved by suppressing the TLR4 and MIP-1alpha/CCR1 signaling pathways.
circulation_biomarker_diagnosis_down	34237753	hsa-mir-27a	Pulpitis	A high level of TLR4 was also detected in both peripheral blood monocytes and pulp tissues from pulpitis patients and showed a negative association with the miR-27a-3p level.
transcription factor target	34237654	hsa-mir-20a	Leukemia	Additionally, their alteration may be related to CD8(+) T cell dysfunction in CML patients; thus, NFAT2 and miR-20a-5p may be considered potential targets for revising T cell function in leukemia immunotherapy.
circulation_biomarker_diagnosis_ns	34237654	hsa-mir-20a	Nephritis, Interstitial	We further demonstrate that the NFAT2-induced activation, differentiation, and expression of cytokines in human umbilical cord blood CD8(+) naive T cells are miR-20a-5p dependent.
transcription factor target	34237654	hsa-mir-20a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Additionally, their alteration may be related to CD8(+) T cell dysfunction in CML patients; thus, NFAT2 and miR-20a-5p may be considered potential targets for revising T cell function in leukemia immunotherapy.
lncRNA target	34237642	hsa-mir-133a	Inflammation	In contrast, miR-133a decreased significantly apoptosis and inflammation in the cells. Overall, results indicated that circ08409 could relieve the inhibitory effect of miR-133a on TGFB2 expression by combining with miR-133a and subsequently modulating cell proliferation, apoptosis and inflammation.
other	34237309	hsa-mir-223	Prostatic Neoplasms	3p in promoting radiotherapy resistance of PCa cells by activating glycolysis.
lncRNA target	34237299	hsa-mir-4677	Glioma	Our data showed that GLIDR affects the proliferation and apoptosis of glioma cells by targeting miR3p to regulate the expression of MAGI2.
other	34236827	hsa-mir-22	Adenocarcinoma of Lung	3p may be involved in the tumor progression of lung adenocarcinoma and may serve as a biomarker for the diagnosis and prognosis of lung adenocarcinoma.
genetics_overexpression_suppress	34236826	hsa-mir-373	Uterine Cervical Neoplasms	AKT1 overexpression rescued the proliferation of cervical cancer cells transfected with miR
lncRNA target	34236821	hsa-mir-128	nonobstructive coronary artery disease	Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR3p.
lncRNA target	34236760	hsa-let-7b	Lung Neoplasms	The results suggest that this aerosolized let-7b mimic is a promising approach for lung cancer prevention, and that the in vivo tumor inhibitory effects of let-7b are mediated, at least in part, by immune-promoting effects via downregulating PD-L1 in tumors and/or PD-1 on CD8+ T cells.
other	34236626	hsa-mir-19a	Nasopharyngeal Carcinoma	Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells.
other	34236626	hsa-mir-92a	Nasopharyngeal Carcinoma	Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells.
other	34236626	hsa-mir-130a	Nasopharyngeal Carcinoma	Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells.
other	34236362	hsa-mir-9	Stomach Ulcer	The results showed that CPS-II could reduce oxidative stress and inflammatory response by regulating the miR5p-MEK/ERK signaling pathway, thus protecting the gastric mucosa and improving stress gastric ulcers.
transcription factor target	34236149	hsa-mir-675	Carcinoma, Hepatocellular	CONCLUSIONS: The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR5p and down-regulate HLA-ABC via HK2 in HCC cells.
genetics_overexpression_promote	34236145	hsa-mir-578	Adenocarcinoma of Lung	CONCLUSIONS: In summary, our data show that the overexpression of hsa_circ_0008274 repressed the proliferation and invasion of LUAD through downregulating miR-578 and activating HMGA2.
genetics_knock down_promote	34236115	hsa-mir-224	Mouth Neoplasms	5p inhibitor-transfected amoeboid-like CD44(high) OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA.
genetics_GWAS	34235620	hsa-mir-544a	Colorectal Neoplasms	In this study, we investigated the KRAS status in correlation with clinicopathological features in sporadic CRC and more importantly the role of let-7a-5p and miR-544a-3p in the regulation of wild-type KRAS protein expression in the tumor center (T1) and invasive tumor front (T2). Our results suggest the role of the KRAS-LCS6 polymorphism and miR-544a-3p expression in the regulation of wild-type KRAS protein expression in sporadic CRC.
genetics_overexpression_promote	34235595	hsa-mir-122	Pancreatitis	These results provided evidence that miR-122 overexpression impaired intestinal barrier function via regulation of occludin expression, thus promoting AP progression.
transcription factor target	34235224	hsa-mir-200a	Liver Cirrhosis	Based on the data from GSE14323, the expression of EGFR, STAT3, CTNNB1, and TP53 targeted by miR-200a-3p was significantly downregulated in fibrotic liver samples. In conclusion, it is demonstrated that miR-20a-5p and miR-200a-3p were identified as the novel liver fibrosis-associated miRNAs, which may play critical roles in liver fibrogenesis.
exosome	34234888	hsa-mir-384	Acute Lung Injury	Therefore, exosomal miR5p could be demonstrated as a promising therapeutic strategy for ALI/ARDS.
lncRNA target	34234865	hsa-mir-519b	Colorectal Neoplasms	Furthermore, we found that SNHG14 functions as a sponge for miR-519b-3p, while the DEAD box protein 5 (DDX5) is a downstream target gene of miR-519b-3p, and the functions of miR-519b-3p inhibitors on the CRC progression could be rescued by downregulation of DDX5. Our findings suggest that SNHG14 promotes the CRC progression by miR-519b-3p/DDX5 axis, implying the promising therapeutic target of SNHG4 for CRC patients.
genetics_overexpression_promote	34234863	hsa-mir-124	Nasopharyngeal Carcinoma	Overexpression miR
other	34234862	hsa-mir-127	Stomach Neoplasms	circALPL Sponges miR-127 to Promote Gastric Cancer Progression by Enhancing MTDH Expression.
lncRNA target	34234851	hsa-mir-203	Carcinoma, Hepatocellular	Conclusion: Our study suggested that miR-203 could be a novel predictor in early-stage HCC and might also be a potential molecular target for HCC therapy.
lncRNA target	34234811	hsa-mir-431	Intervertebral Disc Degeneration	5p/DISC1 is involved in the pathogenesis of IDD, which might be helpful in determining the diagnostic biomarkers and providing potential therapeutic targets for patients with IDD.
other	34234808	hsa-mir-1184	Urinary Bladder Neoplasms	In conclusion, the circCA12/miRNA-1184/RAS family was identified as a regulatory axis in UBC progression.
transcription factor target	34234781	hsa-mir-182	Allergic Inflammation	MiR5p mimic inhibited allergic inflammation both in vitro and in vivo.
target gene	34234564	hsa-mir-567	Uterine Cervical Neoplasms	Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis.
other	34234557	hsa-mir-1224	Glioma	3p-MELK, that regulate the pathogenesis of LGG were ultimately identified.
target gene	34234553	hsa-mir-1245b	Prostatic Neoplasms	Long Noncoding RNA AATBC Promotes the Proliferation and Migration of Prostate Cancer Cell Through miR-1245b-5p/CASK Axis.
transcription factor target	34234551	hsa-mir-212	Carcinoma, Hepatocellular	3p/SLC6A1 axis could serve as a crucial therapeutic target for HCC.
genetics_overexpression_promote	34234548	hsa-mir-758	Stomach Neoplasms	The overexpression of miR-758 neutralized the ZNF217-mediated effects on facilitating the progression of GC.
other	34234459	hsa-mir-29b	Choriocarcinoma	The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells.
other	34234459	hsa-mir-520a	Choriocarcinoma	The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells.
other	34234459	hsa-mir-519c	Choriocarcinoma	The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells.
transcription factor target	34234438	hsa-mir-126a	Ischemic Stroke	CONCLUSION: MiR-126a-5p is a novel potential target for ischemic stroke therapy due to its protection against cerebral I/R injury via directly targeting NOX2.
transcription factor target	34233850	hsa-mir-335	Non-alcoholic Fatty Liver Disease	5p had inhibitory effect on the development of NASH.
circRNA target	34233716	hsa-mir-15b	Diabetic Retinopathy	CONCLUSION: Upregulation of circ_001209 contributes to vascular dysfunction in diabetic retinas through regulating miR-15b-5p and COL12A1, providing a potential treatment strategy for diabetic retinopathy.
genetics_overexpression_suppress	34233701	hsa-mir-30	Intervertebral Disc Degeneration	Moreover, the overexpression of miR
other	34233694	hsa-mir-126	Diabetes Mellitus	a correlated with wound healing.
other	34233694	hsa-mir-21	Diabetes Mellitus	a correlated with wound healing.
other	34233694	hsa-mir-1	Diabetes Mellitus	a correlated with wound healing.
other	34233694	hsa-mir-99b	Diabetes Mellitus	a correlated with wound healing.
other	34233673	hsa-mir-21	COVID-19	5p in the regulation of pro-inflammatory genes in CHPV infected human microglial cells.
target gene	34233668	hsa-mir-513c	Breast Neoplasms	CONCLUSION: MiR-513c and miR-3163 were downregulated in BC tissues, which might serve as tumor suppressors.
target gene	34233668	hsa-mir-3163	Breast Neoplasms	CONCLUSION: MiR-513c and miR-3163 were downregulated in BC tissues, which might serve as tumor suppressors.
other	34233591	hsa-let-7e	Diabetes, Gestational	5p and downregulated expression of SGOL1, RRM2, RGS5, CDK1 and CENPA.
genetics_knock down_promote	34233586	hsa-mir-145	Uterine Cervical Neoplasms	KLF5-induced overexpression of DANCR promotes CC progression via suppressing miR
genetics_knock down_promote	34233454	hsa-mir-21	Plaque, Atherosclerotic	Mir21 knockout in bone marrow cells also reduced atherosclerosis and necrotic core size.
genetics_overexpression_promote	34233436	hsa-mir-23a	Diabetes Mellitus, Type 2	Only miR-23a-3p was significantly overexpressed in the diabetes group compared with the control group (DPP-4 inhibitor vs. control, p = 0.01; sulfonylurea vs. control, p = 0.007). The miR-23a levels were higher in diabetic participants than in nondiabetic controls.
exosome	34233294	hsa-mir-944	Glioma	These findings demonstrate that GSC-derived exosomal miR-944 inhibits glioma growth, progression, and angiogenesis by suppressing VEGFC expression and inhibiting the AKT/ERK signaling pathway.
exosome	34233088	hsa-mir-619	Carcinoma, Hepatocellular	CONCLUSION: The exosome circCMTM3/miR5p/SOX9 axis from HCC cells promotes angiogenesis and thus contributes to HCC tumorigenesis.
lncRNA target	34232945	hsa-mir-345	Cholangiocarcinoma	The E2F1/LMCD1-AS1/miR5p/COL6A3 axis is a newly identified regulatory mechanism, which has a function in cholangiocarcinoma (CCA) tumorigenesis and progression and provides potential therapeutic targets for CCA.
lncRNA target	34232945	hsa-mir-106b	Osteosarcoma	LMCD1-AS1 modulates the survival of osteosarcoma via targeting miR-106b-5p.
lncRNA target	34232945	hsa-mir-1287	Hypoadrenocorticism, Familial	In THCA development, LMCD1-AS1 exerts protumorigenic function through sponging miR
genetics_knock down_promote	34232917	hsa-mir-181c	Adenocarcinoma of Lung	Knockdown of LINC00665 induced obvious inhibitions in cell viability, clone formation, invasion and tumorigenesis in LUAD cells, whereas miR-181c-5p downregulation significantly neutralized these effects.
lncRNA target	34232796	hsa-mir-26a	Penile Neoplasms	These results suggest that miR-26a might regulate HPV-positive progression from CA to PSCC through modulating PTEN.
other	34232332	hsa-mir-29b	Esophageal Squamous Cell Carcinoma	CONCLUSION: Silencing of miR-29b in ESCC cells can increase expression of BTG2 and decrease the level of intracellular cyclin D1, resulting in cell cycle arrest and accumulation in the G0/G1 phase.
lncRNA target	34232111	hsa-mir-146a	Prostatic Neoplasms	Moreover, the inhibition of miR-146a-5p partially counteracted the effects of lncRNA CRNDE on PC cell proliferation, migration, and invasion. In conclusion, lncRNA CRNDE may serve as a cancer promoter in PC by targeting miR-146a-5p.
transcription factor target	34231397	hsa-mir-148a	Irritable Bowel Syndrome	Acupuncture might downregulate miR-148a-3p through multiple pathways to alleviate or relieve IBS-D symptoms.
transcription factor target	34231241	hsa-mir-622	Prostatic Neoplasms	Findings demonstrate a novel mechanism by which miR-622 modulates PCa cells' metastasis by targeting metastatic genes. These data confirm the tumour-suppressive function of miR-622 in PCa cells by enhancing apoptosis and reducing metastasis.
genetics_knock down_promote	34231101	hsa-mir-345	Carcinoma, Hepatocellular	CONCLUSION: Circ-STIL knockdown suppressed HCC development by regulating miR
other	34230985	hsa-mir-394	Eye Diseases	MiR394 plays a negative role in tomato resistance to late blight.
genetics_knock down_promote	34230950	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	Circ_0001666 knockdown reduced the cell viability and promoted the apoptosis of NSCLC cells, which could be reversed by miR
genetics_knock down_promote	34230481	hsa-mir-455	Cartilage Diseases	Furthermore, knockdown of HIF-2alpha in 6-month-old miR-455 knockout cartilage rescues the elevated expression of cartilage degeneration-related genes.
genetics_knock down_promote	34230224	hsa-mir-365	Glioma	Knockdown of PVT1 and overexpression of miR-365 inhibited proliferation, migration, invasion and promoted stemness and Temozolomide (TMZ) resistance of glioma cells.
lncRNA target	34230221	hsa-mir-579	Pancreatic Carcinoma	CONCLUSIONS: Our observations highlighted that HCG11 contributed to the progression of pancreatic carcinoma by promoting growth and aggressiveness, and inhibiting apoptosis via miR3p/MDM2/Notch/Hes1 axis.
other	34229821	hsa-mir-590	Uterine Cervical Neoplasms	And the role of Mir3P in the development and progression of cervical cancer.
genetics_knock down_promote	34229645	hsa-mir-4500	Colonic Neoplasms	Restored MAP3K13 expression or miR-4500 knockdown partially abrogated the effects of silencing LINC01287 in colon cancer cells. CONCLUSION: Our findings demonstrated that the LINC01287/miR-4500/MAP3K13 axis promoted progression of colon cancer.
exosome	34229586	hsa-mir-141	Intervertebral Disc Degeneration	Taken together, we concluded that PRP secreted exosomal miR3p to activate the Keap1-Nrf2 pathway, which helped to slow down IVD degeneration.
other	34229450	hsa-mir-145	Uterine Cervical Neoplasms	Conclusion: The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.
other	34229450	hsa-mir-143	Uterine Cervical Neoplasms	Conclusion: The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC.
other	34229300	hsa-mir-424	Osteoporosis	Our findings may bring evidence for miR5p as a new biomarker for the treatment of osteoporosis.
lncRNA target	34228857	hsa-mir-382	Bronchopulmonary Dysplasia	5p may suppress M1 macrophage activation and inflammatory response via inhibiting CDK8, thereby regulating the development of BPD, which is possibly mediated by STAT1 signaling.
genetics_knock down_promote	34228643	hsa-mir-26a	Depression	The knockdown of miR-26a-3p in DG regions of normal control rats induced depression-like behaviors, effects that were accompanied by activation of the PTEN/PI3K/Akt signaling pathway and neuronal deterioration via suppression of autophagy, impairments in synaptic plasticity, and promotion of neuronal apoptosis.
genetics_knock down_suppress	34228494	hsa-mir-335	Hypertrophy	Gain- and loss-function assays were performed to determine the role of SNHG20/miR-335/Galectin-3 in cardiac fibrosis. Our study revealed that downregulation of SNHG20 improved angiotensin II-induced cardiac fibrosis by targeting the miR-335/Galectin-3 axis, suggesting that SNHG20 is a therapeutic target for cardiac fibrosis and hypertrophy.
genetics_knock down_suppress	34228494	hsa-mir-335	Cardiomyopathies	Gain- and loss-function assays were performed to determine the role of SNHG20/miR-335/Galectin-3 in cardiac fibrosis. Our study revealed that downregulation of SNHG20 improved angiotensin II-induced cardiac fibrosis by targeting the miR-335/Galectin-3 axis, suggesting that SNHG20 is a therapeutic target for cardiac fibrosis and hypertrophy.
other	34228324	hsa-mir-346	Carcinoma, Non-Small-Cell Lung	Taken together, circ_0069244 restrained NSCLC progression by modulating the miR5p/XPC axis.
other	34228237	hsa-let-7a	Osteoporosis	In OP samples, miRNA let-7a-5p was notably declined while RNA KCNQ1OT1 were remarkably up-regulated.
other	34227918	hsa-mir-34a	Takotsubo Cardiomyopathy	This rat model may provide a useful tool for investigating the causal relationship between miR-34a expression, mitochondrial (dys)function, and cardiac alterations under stressful conditions, which could have important implications in the context of stress-related cardiac disease.
other	34227918	hsa-mir-34a	Heart Diseases	This rat model may provide a useful tool for investigating the causal relationship between miR-34a expression, mitochondrial (dys)function, and cardiac alterations under stressful conditions, which could have important implications in the context of stress-related cardiac disease.
lncRNA target	34227845	hsa-mir-98	Ischemic Stroke	In conclusion, our data demonstrated that XIST facilitated the progression of ischemic stroke through regulating the miR-98/BACH1 axis.
other	34227673	hsa-let-7a	Adenomyosis	These data suggested that 17betaestradiol collaborates with the let7a/Lin28B axis to affect the development of ADS.
genetics_knock down_suppress	34227151	hsa-mir-4458	Breast Neoplasms	Circ_0001667 knockdown blocks cancer progression and attenuates ADM resistance by depleting NCOA3 via releasing miR-4458 in breast cancer.
lncRNA target	34227092	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: FAM201A could target miR-101 and upregulate Vimentin to inhibit lung cancer progression.
genetics_overexpression_suppress	34226687	hsa-mir-34a	Prostatic Neoplasms	We found that miR-34a overexpression significantly inhibited the cell cycle, viability, and migration of PCa cells by targeting its downstream genes.
transcription factor target	34226680	hsa-mir-21	Colorectal Neoplasms	Our results identify a novel molecular loop involving MIR21 dysregulation, JAM-A silencing and activation of multiple oncogenic pathways in promoting invasiveness and metastasis in CRC.
other	34226620	hsa-mir-17	Prostatic Neoplasms	5p was an independent negative prognostic factor in PCa.
transcription factor target	34226586	hsa-mir-1246	Neoplasm Metastasis	Among the soluble factors secreted from highly metastatic tumors, we focused on EVs and determined that miR-1246 was contained at a higher level in highly metastatic tumor EVs than in low metastatic tumor EVs. These results suggested that highly metastatic tumors induce drug resistance in ECs by transporting miR-1246 through EVs.
lncRNA target	34226568	hsa-mir-137	Schizophrenia	Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957).
other	34226568	hsa-mir-34c	Schizophrenia	Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls.
other	34226568	hsa-mir-34b	Schizophrenia	Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset.
other	34226539	hsa-mir-335	Adenocarcinoma of Lung	5p/NLRP1/NLRP7 regulatory axis, which may also play an important role in the progression of LUAD.
lncRNA target	34226535	hsa-mir-133a	Hypertrophy	The inhibition of the miR-133a on cardiac proliferation and hypertrophy could be prevented by silencing of Fto (FTO alpha-ketoglutarate dependent dioxygenase) which induced m6A modification.
lncRNA target	34226533	hsa-mir-127	Thyroid Cancer, Papillary	In short, our findings indicated that LINC00284-miR5p-E2F7 axis exerted oncogenic properties in PTC and may offer a new promising target for the diagnosis and therapy of PTC.
circRNA target	34226531	hsa-mir-567	Colorectal Neoplasms	Our findings clarified the Circ_0030998/miR-567/VEGFA regulation axis and indicated that Circ_0030998 could be a potential therapeutic target for CRC.
other	34226522	hsa-mir-4766	Esophageal Neoplasms	5p/LAMA1 axis functions as an oncogenic factor in promoting ESCC cell proliferation, migration, and invasion by inducing EMT, implying its potential prognostic and therapeutic significance in ESCC.
lncRNA target	34226413	hsa-mir-127	Colorectal Neoplasms	Our research reveals that LINC00174 affected the biological characteristics of CRC cells through regulated miR
lncRNA target	34226299	hsa-mir-144	Colorectal Neoplasms	3p inhibited ZEB1 and ZEB2 expression and was negatively correlated with their expression in CRA.
genetics_knock down_promote	34226297	hsa-mir-9	Stomach Neoplasms	In conclusion, ZNRD1-AS1 levels were upregulated in gastric cancer tissues, and knockdown of ZNRD1-AS1 suppressed gastric cancer cell proliferation and metastasis by targeting the miR5p/HSP90AA1 axis.
target gene	34225726	hsa-mir-134	Breast Neoplasms	Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer.
genetics_knock down_promote	34225723	hsa-mir-133a	Glioblastoma	CONCLUSION: Tim-1 knockdown inhibited glioblastoma cell proliferation, invasion, and migration through the miR-133a/TGFBR1 axis and restrained the activation of the Wnt/beta-catenin pathway.
lncRNA target	34225636	hsa-mir-485	Melanoma	CONCLUSION: Together, these results suggest that MIR155HG is capable of promoting melanoma cell proliferation via the miR
lncRNA target	34225531	hsa-mir-15a	Pterygium	CONCLUSIONS: Our study demonstrated that decreased expression of miR-15a in pterygium might be associated with the apoptosis and proliferation of abnormal cell via regulating BCL-2, which could subsequently contribute to the development of pterygium.
other	34225433	hsa-mir-495	Carcinoma, Hepatocellular	In addition, miR-495 has a certain effect on the proliferation and migration ability of MHCC-97H HCC cells.
lncRNA target	34225215	hsa-mir-198	Stomach Neoplasms	MiR-198 inhibitor reversed the effect of circPLEC downreguAlation in PTX-resistant GC cells, and MUC19 downregulation weakened GC resistance to PTX and tumorigenesis and improved the apoptosis of PTX-resistant GC cells. In summary, circPLEC acts as a sponge of miR-198 to promote the PTX resistance and tumorigenesis of GC cells by regulating MUC19 expression.
other	34224858	hsa-mir-155	Immune-Mediated Inflammatory Diseases	Although the results were not so prominent in NAFLD, miR-155 displayed a downward trend in the placebo group (p = 0.054) whereas the levels did not changed significantly in the Mastiha group in patients with less advanced fibrosis.
lncRNA target	34224818	hsa-mir-181c	Ischemic Stroke	CONCLUSION: Our results indicated that SNHG14 promoted neurons injury through regulating miR-181c-5p/BMF axis, suggesting that SNHG14 might be a potential target to alleviate IS-induced brain injury.
lncRNA target	34224325	hsa-mir-143	Uterine Cervical Neoplasms	Overall, the data indicated that the MEOX2-AS1/miR3p/VDAC1 pathway participated in CC progression, making it a novel therapeutic target for CC cures.
other	34224319	hsa-mir-149	Brain Ischemia, Acute	5p and provide references for the treatment of neurological diseases, 60 male SD rats aged 7-8 weeks were selected and divided randomly into test group (establishing middle cerebral artery occlusion (MCAO) model) and control group (no modeling).
circRNA target	34224315	hsa-mir-580	Osteosarcoma	CircRAB3IP promotes OS cells proliferation, migration, and invasion through modulating miR
lncRNA target	34224294	hsa-mir-625	Stomach Neoplasms	In conclusion, LINC00511 promotes the GC cell proliferation and migration via targeting the miR
genetics_overexpression_suppress	34223779	hsa-mir-1231	Carcinoma, Non-Small-Cell Lung	Overexpression of miR-1231 inhibited NSCLC cell proliferation, migration and invasion.
genetics_overexpression_promote	34223709	hsa-mir-383	Liver Neoplasms	HULC and VAMP2 were overexpressed whereas miR
genetics_overexpression_promote	34223709	hsa-mir-383	Carcinoma, Hepatocellular	HULC and VAMP2 were overexpressed whereas miR
lncRNA target	34222668	hsa-mir-655	Retinoblastoma	3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2).
genetics_overexpression_suppress	34222652	hsa-mir-126	Vascular Diseases	The expression of miR-126 is downregulated in a variety of vascular diseases, and miR-126 overexpression appears to beneficial for most vascular disease models.
other	34222420	hsa-mir-671	Colorectal Neoplasms	After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC.
other	34222420	hsa-mir-765	Colorectal Neoplasms	After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC.
other	34222420	hsa-mir-601	Colorectal Neoplasms	After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC.
lncRNA target	34222341	hsa-mir-378a	Osteosarcoma	Rescue assays showed that SSH2 upregulation or miR-378a-3p inhibition counteracted the inhibitory effect of LINC00174 depletion in OS cell growth.
lncRNA target	34222244	hsa-mir-29a	Reperfusion Injury, Testicular Ischemia	In summary, our research indicates that MEG3 contributes to pyroptosis by regulating miR-29a and PTEN during testicular I/R, indicating that MEG3 may be a potential therapeutic target in testicular torsion.
circulation_biomarker_prognosis_down	34222137	hsa-mir-607	Carcinoma, Pancreatic Ductal	CONCLUSIONS: Low serum miR-607 level may serve as a potential diagnostic and prognostic biomarker through regulation of tumor metastasis in PDAC patients.
target gene	34221989	hsa-mir-497	Breast Neoplasms	LncRNA FGD5-AS1 Facilitates the Radioresistance of Breast Cancer Cells by Enhancing MACC1 Expression Through Competitively Sponging miR-497-5p.
transcription factor target	34221869	hsa-mir-21	Liver Neoplasms	Mechanistically, LIX1L increased miR3p expression, which targeted and suppressed FBP1, thereby promoting HCC growth and metastasis.
other	34221706	hsa-mir-195	Vasospasm, Intracranial	5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury.
other	34221706	hsa-mir-195	Subarachnoid Hemorrhage	5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury.
other	34221706	hsa-mir-195	Brain Injuries	5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury.
circulation_biomarker_diagnosis_ns	34221208	hsa-mir-155	Rhinitis, Allergic	CONCLUSION: MiR-155 expression levels were elevated in the serum of AR children.
genetics_overexpression_promote	34221105	hsa-mir-18a	Liver Neoplasms	Overexpressing miR-18a-5p could promote the progression of liver cancer cells and inhibit cell apoptosis. miR-18a-5p and FBP1 are expected to be candidates for liver cancer treatment.
genetics_knock down_suppress	34221014	hsa-mir-124	Uterine Cervical Neoplasms	In vivo assays, overexpression of miR-124, or knockdown of MALAT1 exhibited beneficial effects on tumor weight, size, and volume, together with elevating the survival rate, tightly related with the progression of cervical cancer.
genetics_overexpression_promote	34221007	hsa-mir-148b	Irritable Bowel Syndrome	Mimicking the IBS-exo treatment, miR-148b-5p overexpression increased cell permeability and downregulated RGS2 expression, which were abrogated by overexpressing RGS2.
transcription factor target	34220972	hsa-mir-181a	Cardiomyopathies	CONCLUSIONS: Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and inflammation through directly targeting XIAP.
other	34220948	hsa-mir-192	Stomach Neoplasms	3p.
circulation_biomarker_diagnosis_down	34220670	hsa-mir-1299	Meniere Disease	miRNA-1299 was validated to be downregulated in both the serum and perilymph of Meniere's patients.
genetics_knock down_promote	34220411	hsa-mir-937	Hamartoma Syndrome, Multiple	In contrast, inhibiting miR-937 impeded cells proliferation, promoted cells apoptosis and elevated levels of IL-6, IL-17 and TNF-alpha, which could be rescued by IL1B-knockdown in CSE-induced HBEs.
transcription factor target	34220338	hsa-mir-29a	Sepsis	Targeting miR-29a-5p may be a novel therapeutic strategy to suppress sepsis-induced vascular inflammation.
lncRNA target	34219538	hsa-mir-27a	Asthma	Role of miR-27a in the regulation of cellular function via the inhibition of MAP2K4 in patients with asthma.
genetics_knock down_suppress	34219377	hsa-mir-526b	Carcinoma, Non-Small-Cell Lung	Circ_0001821 knockdown reduced colony formation ability and metastasis ability but enhanced TAX sensibility and apoptosis of NSCLC cells, which was attenuated by miR-526b-5p inhibition or GRK5 overexpression.
genetics_knock down_promote	34219206	hsa-mir-338	Breast Neoplasms	Circ-TFF1 knockdown suppressed BC progression by regulating miR
lncRNA target	34218800	hsa-mir-100	Ovarian Neoplasms	5p to inhibit the progression of OC.
genetics_GWAS	34218555	hsa-mir-452	Hearing Loss, Noise-Induced	Objective: To investigate the relationship between rs1053005 of signal conversion and transcription activator 3 (STAT3) and miR3p, and the association between STAT3 gene polymorphism and noise-induced hearing loss (NIHL) .
exosome	34218459	hsa-mir-146a	Hepatitis C	In addition, miR-122 and miR-146a levels in extracellular exosomes from HCV-infected cells were dramatically increased whereas intracellular miR122 and miR-146a expression had no large changes.
exosome	34218459	hsa-mir-122	Hepatitis C	In addition, miR-122 and miR-146a levels in extracellular exosomes from HCV-infected cells were dramatically increased whereas intracellular miR122 and miR-146a expression had no large changes.
exosome	34218325	hsa-mir-181a	Nasopharyngeal Carcinoma	CONCLUSION: This study concluded that hUC-MSCs-derived exosomal miR-181a retards NPC development via negatively modulating KDM5C, serving as a candidate reference for the therapy of NPC.
lncRNA target	34218270	hsa-mir-625	Melanoma	Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR5p/PKM2 axis.
genetics_GWAS	34218253	hsa-mir-155	Carcinoma, Renal Cell	Our findings reveal that SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1alpha signaling.
other	34218230	hsa-mir-449a	Acute Kidney Injury	INTRODUCTION: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA).
lncRNA target	34218230	hsa-mir-449a	Arthritis	INTRODUCTION: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). CONCLUSION: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs.
circulation_biomarker_diagnosis_up	34218203	hsa-mir-20a	Pre-Eclampsia	The correlation between miR-320a expression and EOPE clinical indicators [mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count] was analyzed.
exosome	34217892	hsa-mir-1246	Glioma	2-Methoxyestradiol suppresses MDSC activation by inhibiting hypoxia-driven exosomal miR-1246 expression in glioma cells and PD-L1 expression in MDSCs.
other	34216686	hsa-mir-627	Esophageal Squamous Cell Carcinoma	3p/TGFB2 signaling.
lncRNA target	34216580	hsa-mir-212	Spinal Cord Injuries	3p improved functional recovery of SCI rats and inhibited LPS-induced neurocyte apoptosis by targeting PTEN to activate AKT/mTOR pathway.
genetics_overexpression_promote	34216514	hsa-mir-92a	Uterine Cervical Neoplasms	Overexpression of PIK3R1 reversed the promotional effect of overexpressed miR-92a on the proliferation, migration, and invasion of cervical cancer.
circulation_biomarker_diagnosis_down	34216249	hsa-mir-101	Bradycardia	The plasma levels of miR3p and miR-30a-5p were markedly downregulated in patients who experienced hypotension and bradycardia, respectively (P < 0.05).
circulation_biomarker_diagnosis_down	34216249	hsa-mir-101	Hypotension	The plasma levels of miR
circRNA target	34215252	hsa-mir-758	Osteosarcoma	RESULTS: Circ_0001721 and TCF4 were upregulated, whereas miR-758 was down-regulated in DXR-resistant OS tissues and cells. CONCLUSION: Circ_0001721 potentiated DXR resistance and facilitated the progression of OS by regulating miR-758/TCF4 axis, which provides promising therapeutic targets for OS treatment.
lncRNA target	34215132	hsa-mir-101	Alzheimer Disease	miRNA-101, an Alzheimer-related biomarker, was used as a model target to validate the performance of the acoustic aggregation-induced separation assay.
lncRNA target	34214903	hsa-mir-146a	Heart   Transplant Rejection	The purpose of this study was to investigate the effect of the interaction of the lncRNA PVT1 and miR-146a on Treg autophagy and reveal the mechanism to alleviate transplant rejection.
other	34213736	hsa-mir-100	Hypertension, Pregnancy-Induced	MiR5p is revealed to be downregulated in gestational hypertension, while its underlying regulatory mechanism remains unclear.
other	34212978	hsa-mir-744	Diabetic Nephropathies	In conclusion, the results of the present study suggested that the lncRNA HOTTIP may promote the fibrosis of lung tissues by downregulating the expression levels of miR7445p and upregulating the expression levels of PTBP1.
lncRNA target	34212977	hsa-mir-199a	Varicose Veins	In conclusion, miR199a5p may be a novel regulator of phenotypic switching in VSMCs by targeting FOXC2 during varicose vein formation.
other	34212545	hsa-mir-28	Asthma	3p in asthmatics sensitized to mulberry.
other	34212545	hsa-mir-28	Asthma, Allergic, Seasonal	3p in asthmatics sensitized to mulberry.
other	34212545	hsa-let-7d	Asthma	3p in asthmatics sensitized to mulberry.
other	34212545	hsa-let-7d	Asthma, Allergic, Seasonal	3p in asthmatics sensitized to mulberry.
genetics_overexpression_suppress	34212311	hsa-mir-21	Colorectal Neoplasms	The activity of the Wnt/B-catenin pathway was assayed through measuring the expression of miR-135b, miR-21, and APC genes by real-time PCR. RESULTS: The results showed the downregulation of miR-135b and miR-21 and overexpression of the APC gene.
genetics_overexpression_suppress	34212311	hsa-mir-135b	Colorectal Neoplasms	The activity of the Wnt/B-catenin pathway was assayed through measuring the expression of miR-135b, miR-21, and APC genes by real-time PCR. RESULTS: The results showed the downregulation of miR-135b and miR-21 and overexpression of the APC gene.
genetics_overexpression_suppress	34212217	hsa-mir-1303	Porphyria, Variegate	RESULTS: Football training down-regulates miR-1303 expression in muscle from VPG compared to CG and the expression of BAG-2, a chaperon protein involved in the autophagy pathway, inversely correlated to overexpression of miR-1303 in a time-dependent manner, indicating that it is a miR-1303 potential target.
circulation_biomarker_diagnosis_ns	34212044	hsa-mir-122	Hepatitis B, Chronic	OBJECTIVE: To investigate the expression of microRNA-122 (miR-122) in the progression of chronic hepatitis B virus- (HBV-) infected liver diseases, thus determining the role of serum miR-122 as a marker of HBV-caused liver injury.
target gene	34211970	hsa-mir-335	Parkinson Disease	miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson's Disease.
circulation_biomarker_diagnosis_up	34211838	hsa-mir-518f	Adenocarcinoma of Lung	Analysis of these circulating miRNAs in pleural mesothelioma cases confirmed that up-regulation of miR-518f-3p,
other	34211089	hsa-mir-200a	Carcinoma, Ovarian Epithelial	MiR-200a, a molecule that downregulates ZEB2, had the opposite effect of ZEB2 expression in EOC-CSLCs.
circulation_biomarker_diagnosis_ns	34209965	hsa-mir-146a	Coronary Artery  Disease	Our results indicate that increased plasma levels of miR-146a-5p and miR
circulation_biomarker_diagnosis_ns	34209965	hsa-mir-21	Coronary Artery  Disease	Our results indicate that increased plasma levels of miR-146a-5p and miR
circulation_biomarker_diagnosis_ns	34209965	hsa-mir-17	Coronary Artery  Disease	Our results indicate that increased plasma levels of miR-146a-5p and miR
genetics_GWAS	34208765	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Our study provides interesting insights on the role of circulating miRNAs, in particular miR-21, and their dynamic change over time in predicting EGFR-TKI response in EGFR-mutated NSCLC.
circulation_biomarker_diagnosis_up	34208452	hsa-mir-221	Acute Coronary Syndrome	RESULTS: The study data showed significant down regulation in the expression of the serum levels of FENDRR lncRNA and miRNA
circulation_biomarker_diagnosis_up	34208452	hsa-mir-197	Acute Coronary Syndrome	RESULTS: The study data showed significant down regulation in the expression of the serum levels of FENDRR lncRNA and miRNA
other	34206912	hsa-mir-27b	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206912	hsa-mir-1a	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206912	hsa-mir-206	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206912	hsa-mir-499	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206912	hsa-mir-133a	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206912	hsa-mir-133b	Hemochromatosis	In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups.
other	34206682	hsa-mir-191	Anorexia Nervosa	5p was increased in the NAR group.
other	34206682	hsa-mir-181d	Anorexia Nervosa	5p was increased in the NAR group.
other	34206682	hsa-mir-181d	Aortic Valve Insufficiency	5p was increased in the NAR group.
other	34206682	hsa-mir-150	Anorexia Nervosa	5p could be related to an increased MBD6 whose deregulation could have clinical consequences.
other	34206682	hsa-mir-191	Aortic Valve Insufficiency	5p was increased in the NAR group.
other	34206682	hsa-mir-150	Aortic Valve Insufficiency	5p could be related to an increased MBD6 whose deregulation could have clinical consequences.
circulation_biomarker_diagnosis_up	34206143	hsa-mir-29a	Carcinoma, Hepatocellular	Serum MIR29A of HCC patients showed decreased levels as compared to that of normal control, with an area under curve (AUC) of 0.751 of a receiver operating characteristic (ROC) curve.
circulation_biomarker_diagnosis_up	34206143	hsa-mir-29	Carcinoma, Hepatocellular	Serum MIR29A of HCC patients showed decreased levels as compared to that of normal control, with an area under curve (AUC) of 0.751 of a receiver operating characteristic (ROC) curve.
other	34204705	hsa-mir-574	COVID-19	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-125b	COVID-19	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-125a	Infertility, Male	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-125b	Infertility, Male	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-125a	COVID-19	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-204	COVID-19	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-936	COVID-19	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-936	Infertility, Male	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-204	Infertility, Male	5p as a modulator of TMPRSS2 are associated with male infertility.
other	34204705	hsa-mir-574	Infertility, Male	5p as a modulator of TMPRSS2 are associated with male infertility.
lncRNA target	34204617	hsa-mir-365	Squamous Cell Carcinoma of Head and Neck	Moreover, the fastest growing oral cancers with the highest viability produced the most miR-365.
transcription factor target	34204585	hsa-mir-146a	Giant Cell Arteritis	Correlative analysis of miR-mRNA quantities demonstrated a highly interrelated expression network of deregulated miRs and mRNAs in temporal arteries and identified KLF4 as a candidate target gene of deregulated miR
other	34204585	hsa-mir-424	Giant Cell Arteritis	MiR5p expression in TABs and the presence of facial or carotid arteritis on ultrasound were associated with vision disturbances in GCA patients.
transcription factor target	34204585	hsa-mir-21	Giant Cell Arteritis	Correlative analysis of miR-mRNA quantities demonstrated a highly interrelated expression network of deregulated miRs and mRNAs in temporal arteries and identified KLF4 as a candidate target gene of deregulated miR
other	34204289	hsa-mir-765	Central Nervous System Neoplasms	Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue.
circulation_biomarker_diagnosis_up	34204158	hsa-mir-425	Breast Neoplasms	5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls.
circulation_biomarker_diagnosis_up	34204158	hsa-mir-145	Breast Neoplasms	5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls.
circulation_biomarker_diagnosis_ns	34204158	hsa-mir-21	Breast Neoplasms	In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls.
circulation_biomarker_diagnosis_up	34204158	hsa-mir-130a	Breast Neoplasms	5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls.
circulation_biomarker_diagnosis_ns	34204158	hsa-mir-182	Breast Neoplasms	In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls.
circulation_biomarker_diagnosis_ns	34204158	hsa-mir-23a	Breast Neoplasms	In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls.
circulation_biomarker_diagnosis_ns	34204158	hsa-mir-155	Breast Neoplasms	In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls.
circulation_biomarker_diagnosis_up	34203979	hsa-mir-21	high grade glioma	3p in serum exosomes may be useful molecular biomarkers for complementing clinical evaluation of early tumor progression during post-surgical therapy in patients with HGG.
circulation_biomarker_diagnosis_ns	34203979	hsa-mir-124	high grade glioma	We previously identified miR-21, miR-222 and miR3p purified from serum exosomes as molecular signature to help pre-operative clinical diagnosis and grading of gliomas.
circulation_biomarker_diagnosis_up	34203979	hsa-mir-222	high grade glioma	3p in serum exosomes may be useful molecular biomarkers for complementing clinical evaluation of early tumor progression during post-surgical therapy in patients with HGG.
target gene	34203557	hsa-mir-203	Pancreatic Neoplasms	Inhibition of miR-222 by Oncolytic Adenovirus-Encoded miRNA Sponges Promotes Viral Oncolysis and Elicits Antitumor Effects in Pancreatic Cancer Models.
other	34203452	hsa-mir-26b	Retinitis	Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription.
other	34203452	hsa-mir-26a	Retinitis	Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription.
other	34203452	hsa-let-7d	Retinitis	Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription.
other	34202571	hsa-mir-650	Non-alcoholic Fatty Liver Disease	RESULTS: in-silico constructed network revealed six mRNAs (YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2), two miRNAs (miR-650 and miR-1205), and two lncRNAs (RPARP-AS1 and SRD5A3-AS1) that play important roles as a co-regulatory network in NAFLD pathogenesis.
other	34202571	hsa-mir-1205	Non-alcoholic Fatty Liver Disease	RESULTS: in-silico constructed network revealed six mRNAs (YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2), two miRNAs (miR-650 and miR-1205), and two lncRNAs (RPARP-AS1 and SRD5A3-AS1) that play important roles as a co-regulatory network in NAFLD pathogenesis.
other	34202375	hsa-mir-24	Mucocutaneous Lymph Node Syndrome	3p significantly higher in KD patients, which may be a potential diagnostic biomarker for KD.
target gene	34201896	hsa-mir-29b-2	Breast Neoplasms	miR-29b2 and miR-29c play a suppressive role in breast cancer progression.
target gene	34201896	hsa-mir-29	Breast Neoplasms	miR-29b2 and miR-29c play a suppressive role in breast cancer progression.
target gene	34201896	hsa-mir-29c	Breast Neoplasms	miR-29b2 and miR-29c play a suppressive role in breast cancer progression.
transcription factor target	34201741	hsa-mir-208b	Cardiomegaly	In summary, miR-208b targets the mRNAs of proteins involved in the generation of cardiac excitation and propagation, as well as of proteins involved in RNA translocation (Ran) and cardiac hypertrophic response (Rock2).
lncRNA target	34201353	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	Our functional assays showed that inhibition of miR
transcription factor target	34201109	hsa-mir-29c	Glaucoma	TGFbeta2 treatment downregulated the expression of multiple miRNAs, including miR-29c-3p, compared to controls in LC cells. LC cells transfected with miR-29c-3p mimics or inhibitors modulated collagen expression.
circulation_biomarker_diagnosis_ns	34200891	hsa-mir-373	Lymphoma, T-Cell, Peripheral	3p, CD44 and RDX was decreased in PTL patients' blood, and their expression were the lowest in PTL patients' blood with inflammation.
circulation_biomarker_diagnosis_ns	34200463	hsa-mir-99a	Breast Neoplasms	Herein, we assessed the potential of a microRNA signature based on miR-30b-5p and miR-99a-5p levels in plasma as a diagnostic biomarker for breast cancer.
circulation_biomarker_diagnosis_up	34200314	hsa-mir-101	Colorectal Neoplasms	Serum PVT1, MALAT1, miRNA-186 and miRNA-101 are novel non-invasive diagnostic biomarkers that could improve the clinical outcome of CRC.
circulation_biomarker_diagnosis_up	34200314	hsa-mir-186	Colorectal Neoplasms	Serum PVT1, MALAT1, miRNA-186 and miRNA-101 are novel non-invasive diagnostic biomarkers that could improve the clinical outcome of CRC.
transcription factor target	34200161	hsa-mir-124	Amyotrophic Lateral Sclerosis	We propose miR-124 as a new therapeutic target and a promising ALS biomarker in patient sub-populations.
genetics_GWAS	34200157	hsa-mir-608	Abortion, Habitual	The purpose of this study was to investigate whether polymorphisms in five microRNAs (miRNAs), miR-604A>G, miR-608C>G, 631I/D, miR-938G>A, and miR3C>T, are associated with the risk of idiopathic recurrent pregnancy loss (RPL).
genetics_GWAS	34200157	hsa-mir-604	Abortion, Habitual	These results reveal a significant association between the miR-604A>G and miR-938G>A polymorphisms and idiopathic RPL and suggest that miRNAs can affect RPL in Korean women.
genetics_GWAS	34200157	hsa-mir-1302	Abortion, Habitual	The purpose of this study was to investigate whether polymorphisms in five microRNAs (miRNAs), miR-604A>G, miR-608C>G, 631I/D, miR-938G>A, and miR3C>T, are associated with the risk of idiopathic recurrent pregnancy loss (RPL).
genetics_GWAS	34200157	hsa-mir-938	Abortion, Habitual	These results reveal a significant association between the miR-604A>G and miR-938G>A polymorphisms and idiopathic RPL and suggest that miRNAs can affect RPL in Korean women.
lncRNA target	34199886	hsa-mir-29	Cholangiocarcinoma	3p-family act as tumor-suppressors in ICC cells.
lncRNA target	34199886	hsa-mir-29a	Cholangiocarcinoma	3p-family act as tumor-suppressors in ICC cells.
other	34199867	hsa-mir-181a	Thyroid Cancer, Papillary	This study shows for the first time that miR-181a-5p directly regulates SLC5A5 expression in the context of PTC and may decrease efficacy of radioiodine treatment.
other	34199767	hsa-mir-146a	Coronary Artery Disease	Conclusions: miR-146a expression levels were negatively correlated with TNF-alpha levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-alpha-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario.
other	34199767	hsa-mir-146	Coronary Artery Disease	Conclusions: miR-146a expression levels were negatively correlated with TNF-alpha levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-alpha-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario.
exosome	34199766	hsa-mir-486	Urinary Bladder Neoplasms	This is the first study to investigate EV-containing miRNA sequencing in pre- and postsurgery BC patient samples and our findings suggest that urinary EV-contained miR-451a and miR5p may be potential biomarkers for recurrence-free survival of BC patients with stage T1 disease.
exosome	34199766	hsa-mir-451a	Urinary Bladder Neoplasms	This is the first study to investigate EV-containing miRNA sequencing in pre- and postsurgery BC patient samples and our findings suggest that urinary EV-contained miR-451a and miR5p may be potential biomarkers for recurrence-free survival of BC patients with stage T1 disease.
other	34199723	hsa-mir-223	Myocardial Infarction	3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI.
other	34199723	hsa-mir-126	Myocardial Infarction	3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI.
circulation_biomarker_diagnosis_ns	34199703	hsa-mir-200a	Endometritis	We aimed (I) to investigate expression profile of eca-miR-155, eca-miR-223, eca-miR-17, eca-miR-200a, and eca-miR-205 (II) and to measure concentrations of interleukin 6 (IL-6), and prostaglandins (PGF(2alpha) and PGE(2)) in serum of mares with healthy and abnormal uterine status (endometritis).
circulation_biomarker_diagnosis_ns	34199703	hsa-mir-205	Endometritis	We aimed (I) to investigate expression profile of eca-miR-155, eca-miR-223, eca-miR-17, eca-miR-200a, and eca-miR-205 (II) and to measure concentrations of interleukin 6 (IL-6), and prostaglandins (PGF(2alpha) and PGE(2)) in serum of mares with healthy and abnormal uterine status (endometritis).
other	34199580	hsa-mir-378a	Carcinoma, Hepatocellular	circGPC3 was further shown to act as a sponge of miR-378a-3p to regulate APSM (Abnormal spindle-like microcephaly associated) expression and modulate cell transformation.
other	34198846	hsa-mir-93	Prostatic Neoplasms	5p miRNAs are suggested to be potential biomarkers for PC risk stratification that could be included in non-invasive strategies such as liquid biopsy in precision medicine for PC management.
lncRNA target	34198800	hsa-mir-941	Severe Acute Respiratory Syndrome	Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date.
lncRNA target	34198800	hsa-mir-941	COVID-19	Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date.
lncRNA target	34198800	hsa-mir-138	Severe Acute Respiratory Syndrome	5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date.
lncRNA target	34198800	hsa-mir-138	COVID-19	Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date.
lncRNA target	34198460	hsa-mir-34a	Atrial Fibrillation	Ulteriorly, the microRNA-transcription factor-mRNA network revealed that microRNA-34a-5p could target both RCAN1 and PPP3R1 in the pAF pathogenesis. In conclusion, our present study revealed several novel pAF-associated genes, miRNAs, and pathways, including microRNA-34a-5p, which might target RCAN1 and PPP3R1 to regulate pAF through the calcineurin-NFAT signaling pathway.
other	34198264	hsa-let-7c	Osteoarthritis	5p expression is a novel strategy for OA and RA.
other	34198264	hsa-mir-149	Arthritis, Rheumatoid	5p expression is a novel strategy for OA and RA.
other	34198264	hsa-mir-149	Osteoarthritis	5p expression is a novel strategy for OA and RA.
other	34198264	hsa-let-7c	Arthritis, Rheumatoid	5p expression is a novel strategy for OA and RA.
circulation_biomarker_diagnosis_ns	34197940	hsa-mir-210	Lupus Erythematosus, Systemic	5p and lower expression of SP1 and HSCARG in peripheral blood mononuclear cells.
other	34197720	hsa-mir-20a	Diabetic Retinopathy	SNHG16 and E2F1 were increased and miR-20a-5p was decreased in proliferative DR both in vivo and in vitro when compared with control or non-proliferative DR. This study indicated that SNHG16 regulated E2F1 expression by sponging miR-20a-5p and aggravating proliferative DR.
circRNA target	34197715	hsa-mir-153	Diabetic Nephropathies	Circ-RBM4 alleviated the renal inflammation and renal fibrosis in DN by targeting the miR3p/NFIC axis.
lncRNA target	34197482	hsa-mir-210	Glioma	3p expression that affect malignant behaviors and chemoresistance via TGF-beta upregulation in glioma cells.
other	34197043	hsa-mir-25	Fibrosis, Renal	These findings suggested that miR-25 cluster played an important role in the progression of IgAN, which provided new insights into the pathogenesis and treatment of IgAN.
circRNA target	34197029	hsa-mir-515	Leukemia, Myeloid, Acute	In conclusion, circTASP1 acts as a sponge for miR5p to regulate HMGA2, thereby promoting proliferation and inhibiting apoptosis during AML progression.
other	34197004	hsa-mir-100	Arthritis	The findings highlight the importance of miR5p/NOX4 axis in primary articular chondrocytes injury and provide new insights into therapeutic strategies for articular chondrocytes injury and osteoarthritis.
other	34197004	hsa-mir-100	Osteoarthritis	The findings highlight the importance of miR5p/NOX4 axis in primary articular chondrocytes injury and provide new insights into therapeutic strategies for articular chondrocytes injury and osteoarthritis.
other	34196940	hsa-mir-137	Nasopharyngeal Carcinoma	The aforementioned findings suggested that the miR-137/ERRalpha-mediated metabolic programming could be involved in the chemoresistance of NPC cells.
genetics_overexpression_promote	34196584	hsa-mir-665	Urinary Bladder Neoplasms	MiR-665 overexpression significantly downregulated the expression of SMAD3, phospho-SMAD3, and SNAIL, reversed epithelial-mesenchymal transition progression, and inhibited the migration of bladder cancer cells.
lncRNA target	34196215	hsa-mir-206	Carcinoma, Hepatocellular	inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells.
circulation_biomarker_diagnosis_up	34196150	hsa-mir-1	Laryngeal Neoplasms	3p (rs=0.443, p=0.039) and miR-196a-5p (rs=0.548; p=0.008) between plasma and adjacent tumour tissue LSCC samples.
circulation_biomarker_diagnosis_ns	34196150	hsa-mir-424	Laryngeal Neoplasms	5p in plasma and tissue samples from patients with advanced laryngeal squamous cell carcinoma (LSCC) and healthy controls.
circulation_biomarker_diagnosis_up	34196150	hsa-mir-196a	Laryngeal Neoplasms	3p (rs=0.443, p=0.039) and miR-196a-5p (rs=0.548; p=0.008) between plasma and adjacent tumour tissue LSCC samples.
circulation_biomarker_diagnosis_ns	34196150	hsa-mir-210	Laryngeal Neoplasms	5p in plasma and tissue samples from patients with advanced laryngeal squamous cell carcinoma (LSCC) and healthy controls.
other	34195933	hsa-mir-125a	Bicuspid Aortic Valve Disease	The results suggested that miR-34a and miR-125a might be implicated in wall shear stress induced aortic pathogenesis due to their apparent regulatory roles in metalloproteinase 2 expression and extracellular matrix remodeling, which are key events in the weakening of aortic walls among BA patients.
other	34195933	hsa-mir-34a	Bicuspid Aortic Valve Disease	The results suggested that miR-34a and miR-125a might be implicated in wall shear stress induced aortic pathogenesis due to their apparent regulatory roles in metalloproteinase 2 expression and extracellular matrix remodeling, which are key events in the weakening of aortic walls among BA patients.
other	34195885	hsa-mir-146a	Sick Sinus Syndrome	The highest risk of SSS was conferred by the combination SCN10A rs6795970*T+FNDC3B rs9647379*C+MIR146A rs2910164*C+SYT10 rs7980799*C+KCNE1 rs1805127*G (OR 2.98, CI 1.77-5.00, P = 1.27 x 10(-5), P(FDR) = 0.022).
genetics_overexpression_suppress	34195851	hsa-mir-138	Carcinoma, Squamous Cell, Cutaneous	Cell lines with a high and low HCP5 expression were screened, and a pcDNA3.1HCP5 overexpression vector, small interfering RNA against HCP5, miR1385p mimics and miR1385p inhibitors were transfected into the CSCC cells.
circulation_biomarker_prognosis_down	34195390	hsa-mir-148a	Breast Neoplasms	Conclusion miRNA-148a and miRNA-30c expressions were down regulated in female patients with breast cancer and might be considered as potential blood biomarkers.
other	34195365	hsa-mir-761	Thyroid Neoplasms	Long non-coding RNA HOTAIR/microRNA-761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma.
genetics_overexpression_promote	34195294	hsa-mir-504	Stomach Neoplasms	Additionally, miR-504 overexpression increased the viability of gastric cancer cells.
exosome	34195287	hsa-mir-208b	Myocardial Infarction	This study was aimed at investigating the effects of myocardial infarction- (MI-) associated extracellular vesicle- (EV-) delivered miR-208b on human umbilical vein endothelial cells (HUVECs).
lncRNA target	34195280	hsa-mir-125a	Dehydration	Further experiments showed that oxidative stress and miR-125a-5p together suppressed the expression of VEGF during osteogenic differentiation of hADSCs and that the inhibition of miR-125a-5p reversed the effect of oxidative stress.
exosome	34195198	hsa-mir-770	Carcinoma, Non-Small-Cell Lung	Tumor Cell-Derived Exosomal miR-770 Inhibits M2 Macrophage Polarization via Targeting MAP3K1 to Inhibit the Invasion of Non-small Cell Lung Cancer Cells.
target gene	34195187	hsa-mir-197	Prostatic Neoplasms	MiR-197 Inhibitor Loaded AbCD133@MSNs@GNR Affects the Development of Prostate Cancer Through Targeting ITGAV.
lncRNA target	34194562	hsa-mir-1539	Intervertebral disc disease	Collectively, the present results suggested that lower RP11-81H3.2 expression levels were associated with higher-grade IDD, and that RP11-81H3.2 inhibited NP cell apoptosis by decreasing the levels of miR-1539 to increase COL2A1 expression levels.
lncRNA target	34194560	hsa-mir-155	Sjogren's Syndrome	5p may serve to be a potential target for the treatment of SS.
target gene	34194557	hsa-mir-26b	Ovarian Neoplasms	Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p.
genetics_knock down_suppress	34194552	hsa-mir-485	Inflammation	Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of lncRNA NORAD, microRNA-485 (miR-485) and nuclear respiratory factor 1 (NRF1) in the tissues of patients with DN and high-glucose (HG)-induced human mesangial cells (HMCs). NORAD knockdown inhibited HG-induced HMC proliferation, inflammation and fibrosis by regulating miR-485/NRF1, providing a possible therapeutic strategy for DN.
genetics_knock down_suppress	34194552	hsa-mir-485	Diabetic Nephropathies	Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of lncRNA NORAD, microRNA-485 (miR-485) and nuclear respiratory factor 1 (NRF1) in the tissues of patients with DN and high-glucose (HG)-induced human mesangial cells (HMCs). NORAD knockdown inhibited HG-induced HMC proliferation, inflammation and fibrosis by regulating miR-485/NRF1, providing a possible therapeutic strategy for DN.
circulation_biomarker_diagnosis_ns	34194551	hsa-mir-20a	Heart Failure	Collectively, the results of the present study demonstrated that miR-320a promoted myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway in HEH2 cells, suggesting that serum exosomal miR-320a may serve as a potential biomarker for the diagnosis of CHF.
other	34194546	hsa-mir-29b	Vitreoretinopathy, Proliferative	The expression levels of miR-29b were positively correlated with E-cadherin mRNA expression, while an inverse correlation was observed between miR-29b and alpha-SMA mRNA expression in epiretinal membranes of patients with PVR.
lncRNA target	34194502	hsa-mir-18a	Esophageal Neoplasms	MATERIALS AND METHODS: RT-qPCR assay was applied to measure the expression of WDFY3-AS2 and miR-18a in EC samples and cells. CONCLUSIONS: WDFY3-AS2 modulates the expressional level of PTEN as a competitive endogenous RNA via sponging miR-18a in EC, which suggests that the WDFY3-AS2/miR-18a/PTEN pathway might be involved in the progression of EC.
circulation_biomarker_diagnosis_ns	34194500	hsa-mir-122	Carcinoma, Hepatocellular	The aim of the study was to explore the association of serum miR-122 with response to sorafenib in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC) patients and to further reveal the effect of the virus load on such potential relationship. CONCLUSION: Higher serum level of miR-122 at baseline was associated with a better response to sorafenib in HBV-related locally advanced HCC patients, and relatively high HBV load weakened such predictive effect mentioned above.
lncRNA target	34194499	hsa-mir-577	Carcinoma, Hepatocellular	CXCL5 was a target gene of miR-577, and its expression was mediated by miR-577 in HCC. The newly identified role of the CXCL5/miR-577/NF-kappaB axis provides novel insights into the targeted therapy of HCC.
other	34194498	hsa-mir-6715	Colorectal Neoplasms	RESULTS: The expression of CST4 in CRC tissues was significantly higher than that in normal paracancerous tissues, but the results for miRNA5p were opposite.
other	34194495	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	These data suggest that chidamide shows a synergistic effect with radiation therapy on lung squamous cell carcinomas by modulating the miREIF4G3 axis, which may afford an effective strategy to overcome the drug resistance of chidamide in clinical cancer therapy.
other	34193814	hsa-mir-95	Diabetic Nephropathies	3p and miR-631 could reflect the severity and prognosis of DN.
other	34193814	hsa-mir-631	Diabetic Nephropathies	3p and miR-631 could reflect the severity and prognosis of DN.
other	34193814	hsa-mir-185	Diabetic Nephropathies	5p, miR-1246, and miR-631 could serve as simple and noninvasive tools to distinguish patients with DM, DN, DM with IgAN, and DM with MN.
genetics_GWAS	34193555	hsa-mir-183	Nonsyndromic sensorineural hearing loss	A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system.
genetics_GWAS	34193555	hsa-mir-183	Hearing Loss	Moreover, the different phenotypic outcomes of different types of mutations in the Mir-183 cluster corroborate the requirement of mutation-tailored therapies in patients with hearing loss.
genetics_GWAS	34193555	hsa-mir-96	Hearing Loss	A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system.
genetics_GWAS	34193555	hsa-mir-96	Nonsyndromic sensorineural hearing loss	A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system.
genetics_knock down_suppress	34193422	hsa-mir-200c	Diabetes, Gestational	Premature senescence and NTDs were abolished by knockout of the transcription factor Foxo3a, the miR-200c gene, and the cell cycle inhibitors p21 and p27; transgenic expression of the dominant-negative FoxO3a mutant; or the senomorphic rapamycin.
genetics_knock down_suppress	34193422	hsa-mir-200c	Neural Tube Defects	Premature senescence and NTDs were abolished by knockout of the transcription factor Foxo3a, the miR-200c gene, and the cell cycle inhibitors p21 and p27; transgenic expression of the dominant-negative FoxO3a mutant; or the senomorphic rapamycin.
lncRNA target	34193130	hsa-mir-636	Endometrial Neoplasms	CONCLUSIONS: In conclusion, this study showed that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis.
lncRNA target	34193130	hsa-mir-636	Carcinoma, Endometrioid	CONCLUSIONS: In conclusion, this study showed that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis.
other	34193018	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	3p, is an oncogenic factor in NSCLC progression.
other	34193018	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	3p, is an oncogenic factor in NSCLC progression.
genetics_GWAS	34192880	hsa-mir-18a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-mir-100	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-mir-145	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-let-7	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-mir-24	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-mir-99a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
genetics_GWAS	34192880	hsa-let-7a	Prostatic Neoplasms	Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR
lncRNA target	34192708	hsa-mir-155	Carcinoma, Renal Cell	5p may promote cell growth of ccRCC via inhibiting PEG3 expression.
lncRNA target	34192661	hsa-mir-222	Osteoarthritis	CONCLUSION: HOTAIR might contribute to IL-1beta-induced chondrocytes death, inflammation, extracellular matrix degradation, and oxidative stress in OA via miR3p/ADAM10 axis.
other	34191854	hsa-mir-196a	Prostatic Neoplasms, Castration-Resistant	In conclusion, this study provides the rational for a role of miR-196a in the beta2-adrenergic receptor mediated neuroendocrine differentiation of LNCaP prostate cancer cells.
genetics_overexpression_promote	34191748	hsa-mir-494	Osteosarcoma	After circ_0081001 was overexpressed, the proliferation, migration, and invasion of OS cells were boosted but the apoptosis was reduced, whereas miR
lncRNA target	34191497	hsa-mir-21	Esophageal Squamous Cell Carcinoma	In particular, MI-Anti-miRNAs that targeted miRNA-21, which is involved in tumor initiation, progression, invasion, and metastasis in several types of cancer, successfully repressed miRNA-21 activity, resulting in a superior antitumor activity in both solid and metastatic tumor models without causing systemic toxicity.
genetics_knock down_promote	34191363	hsa-mir-1	Prostatic Neoplasms	In addition, miR-1 overexpression suppressed PCa cell progression by repressing MAP 3 K1.
genetics_overexpression_promote	34191246	hsa-mir-122	Uterine Cervical Neoplasms	Importantly, overexpression of RAD21 restored the roles of miR-122 in CC.
lncRNA target	34191053	hsa-mir-210	Lymphohistiocytosis, Hemophagocytic	Taken together, our results indicated that lncRNA-MEG3 participated in the inflammatory responses and apoptosis in HPS-infected PAMs through modulating the miR-210/TLR4 axis.
genetics_overexpression_suppress	34191006	hsa-mir-335	Leukemia, Myeloid, Acute	3p overexpression significantly inhibited cell proliferation and induced cell cycle G0/G1 arrest and apoptosis in AML cell lines (THP-1 and U937).
other	34190510	hsa-mir-99b	Carcinoma, Renal Cell	CONCLUSIONS: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment.
target gene	34190442	hsa-mir-155	Breast Neoplasms	Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis.
other	34190406	hsa-mir-27a	Intervertebral Disc Degeneration	The results showed that miR27a was rarely expressed in healthy intervertebral discs but showed increased expression in degenerated intervertebral discs.
lncRNA target	34190001	hsa-mir-139	Esophageal Squamous Cell Carcinoma	5p to upregulate PDE4A via the competing endogenous RNA network in ESCC cells.
genetics_overexpression_suppress	34189997	hsa-mir-491	Carcinoma, Non-Small-Cell Lung	5p downregulation or MAP3K3 overexpression reversed the effect of circ_0006988 silencing on NSCLC cell progression.
other	34189972	hsa-mir-27	Heart Failure	While betalain pre-treated rats prevented the cardiac failure significantly (p < 0.01) with improved anti-oxidant enzymes, abrogated the inflammatory signals with restored matrix proteins, cardiac biomarker genes, and attenuated miR-423 and miR-27 compared to heart failure rats.
other	34189972	hsa-mir-423	Heart Failure	While betalain pre-treated rats prevented the cardiac failure significantly (p < 0.01) with improved anti-oxidant enzymes, abrogated the inflammatory signals with restored matrix proteins, cardiac biomarker genes, and attenuated miR-423 and miR-27 compared to heart failure rats.
circulation_biomarker_prognosis_ns	34189151	hsa-mir-24-2	Carcinoma, Hepatocellular	Additionally, high-serum miR2p in HBV-related HCC patients was associated with cirrhosis, tumor size, clinical stage, and poor overall survival prognosis.
circulation_biomarker_prognosis_ns	34189151	hsa-mir-24	Carcinoma, Hepatocellular	CONCLUSIONS: High-serum miR
transcription factor target	34188710	hsa-mir-744	Glioblastoma	5p targets RFC2 and suppresses the progression of GBM by repressing cellular proliferation, migration and Bcl-2 protein expression, and effectively promoting caspase-3 activity and Bax protein expression.
circulation_biomarker_prognosis_ns	34188709	hsa-mir-433	Carcinoma, Non-Small-Cell Lung	To explore the impact of exosomal miR-433 in non-small cell lung cancer (NSCLC) and understand its mechanism of action in NSCLC progression, the present study isolated the exosomes from the plasma of patients with NSCLC after chemotherapy and found that miR-433 expression was lower in plasma of patients with resistant NSCLC compared with in plasma of patients with sensitive NSCLC and in normal serum.
other	34188706	hsa-mir-32	Carcinoma, Hepatocellular	Therefore, MT1JP may upregulate PTEN by downregulating miR-32 to regulate HCC cell proliferation.
genetics_overexpression_promote	34188550	hsa-mir-375	Uterine Cervical Neoplasms	Overexpression of SNHG17 in CC promoted the progression of CC partly via targeting miR
target gene	34188473	hsa-mir-338	Neuroblastoma	LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis.
genetics_knock down_promote	34188461	hsa-mir-144	Hyperglycemia	MALAT1 functioned as competing endogenous RNA (ceRNA) for miR-144, and pre-treatment with MALAT1 siRNA decreased mTOR activity and p-tau protein level in HG-treated hippocampal cells, which was significantly attenuated by miR-144 mimics. Moreover, miR-144 negatively regulated the expression of mTOR and knockdown of MALAT1 suppressed mTOR, while overexpression of mTOR abrogated protective effects of MALAT1 knockdown in HG-treated hippocampal cells.
genetics_overexpression_promote	34187598	hsa-mir-18a	Carcinoma, Hepatocellular	In HCC cells, circRHOBTB3 overexpression decreased mature miR-18a level but not miR-18a precursor.
genetics_overexpression_promote	34187569	hsa-mir-1291	Leukemia, Myeloid, Acute	Overexpression of PIK3R5 enhanced the promoting effect of HCP5 in the development of AML, while weakened the suppression of miR-1291 to AML progression.
lncRNA target	34187521	hsa-mir-10a	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7f	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7f	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-mir-181b	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7a	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7a	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7g	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-mir-186	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-let-7g	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-mir-186	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-mir-10a	Lymphoma	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187521	hsa-mir-181b	Leukemia-Lymphoma, Adult T-Cell	RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors.
lncRNA target	34187513	hsa-mir-2911	Esophageal Squamous Cell Carcinoma	CONCLUSION: Taken together, honeysuckle-derived miR2911 showed an anti-tumor effect in colon cancer through targeting TGF-beta1 mRNA.
circulation_biomarker_diagnosis_ns	34187448	hsa-mir-93	Inflammation	5p was declined in DN serum samples and HG-treated HGMCs.
circulation_biomarker_diagnosis_ns	34187448	hsa-mir-93	Diabetic Nephropathies	5p was declined in DN serum samples and HG-treated HGMCs.
genetics_overexpression_suppress	34187411	hsa-mir-210	Squamous Cell Carcinoma of Head and Neck	BTG2 (anti-proliferation factor 2) was identified as the target gene of miR-210, and BTG2 overexpression inhibited the proliferation and invasion of LSCC cells. CONCLUSION: The results of this study suggest that TINCR inhibits the proliferation and invasion of LSCC by regulating the miR-210/BTG2 pathway, participates in cell cycle regulation, and may become a target for the treatment of LSCC.
lncRNA target	34187303	hsa-mir-9	Osteoarthritis	In conclusion, our findings illuminated that inhibition of MIR22HG ameliorated IL-1beta-induced apoptosis and ECM degradation of human chondrocytes through miR3p/ADAMTS5 pathway, which may provide a potentially promising target for OA treatment.
other	34187214	hsa-mir-498	Endometrial Neoplasms	In this study, we investigated the mechanisms of lncRNA HOXB cluster antisense RNA 3 (HOXB-AS3), miRNA(miR)5p, and disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) in endometrial carcinoma (EC) cells.
other	34186489	hsa-mir-636	Pulmonary Arterial Hypertension	Two microRNAs (miR-636 and miR5p) were selected by all methods and used to predict PAH diagnosis with high accuracy.
other	34186489	hsa-mir-187	Pulmonary Arterial Hypertension	Two microRNAs (miR-636 and miR5p) were selected by all methods and used to predict PAH diagnosis with high accuracy.
lncRNA target	34186326	hsa-mir-145	Breast Neoplasms	5p targeting SOX2 was identified as a potential predictive biomarker for breast cancer stemness.
other	34186058	hsa-let-7c	Melanoma	Our study demonstrates an MITF-governed biogenesis mechanism that results in differential expression of clustered 99a/let-7c/125b-2 miRNAs that control melanoma progression.
circulation_biomarker_diagnosis_up	34185461	hsa-mir-27a	Breast Neoplasms	Our results exhibited significantly higher expression level of plasma miR-27a in breast cancer patients (median= 8.3 and 19 fold change for early and late stages respectively) compared to controls, high risk group and benign group with (P <0.001) for each.
other	34185416	hsa-mir-146b	Airway Inflammation	In the current study, we aimed to explore whether miR-146a/b could regulate cellular responses to RVs in HBECs and airways during RV-induced asthma exacerbation.
other	34185416	hsa-mir-146b	Respirovirus Infections	In the current study, we aimed to explore whether miR-146a/b could regulate cellular responses to RVs in HBECs and airways during RV-induced asthma exacerbation.
lncRNA target	34185281	hsa-mir-32	Myocardial Infarction	3p regulates myocardial injury induced by micro-embolism and micro-vascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques.
lncRNA target	34185281	hsa-mir-32	Plaque, Atherosclerotic	3p regulates myocardial injury induced by micro-embolism and micro-vascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques.
other	34185245	hsa-mir-17	Leukemia, Myeloid, Acute	5p and Beclin-1.
other	34185228	hsa-mir-199a	Intracranial Aneurysm	Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm.
other	34185228	hsa-mir-125b	Intracranial Aneurysm	Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm.
other	34185228	hsa-mir-143	Intracranial Aneurysm	Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm.
genetics_overexpression_promote	34185205	hsa-mir-548g	Esophageal Squamous Cell Carcinoma	The overexpression of miR-548g also promoted ESCC cell migration and invasion.
lncRNA target	34184952	hsa-mir-760	Osteoporosis	Our results demonstrated that LINC00963 positively regulated the expression of ETS1 by directly targeting miR-760, and then promoted osteogenic differentiation of hBMSCs in vitro, and also attenuated OP progression in vivo, suggesting that LINC00963 might be a potential therapeutic target for OP.
genetics_knock down_suppress	34184734	hsa-mir-8b	Central Nervous System Diseases	Knockdown miR-8b by anti-MIRs method caused severe defects of eyes and CNS.
lncRNA target	34184201	hsa-mir-222	Myocardial Reperfusion Injury	MiR-222 silencing in AC16 cells simulated the phenotypes of MIRI patients and HR-treated cells, indicating that LSINCT5 functions via miR-222 to regulate proliferation and apoptosis of HR-treated AC16 cells. LncRNA LSINCT5 was upregulated during MI pathogenesis, and LSINCT5 regulated MIRI possibly via a potential LSINCT5/miR-222 axis and PI3K/AKT signaling pathway.
lncRNA target	34184135	hsa-mir-582	FG syndrome	In conclusion, hsa_circ_0074371 downregulation inhibited proliferation, migration, and invasion of trophoblast cells via sponging miR
lncRNA target	34184082	hsa-mir-3074	Arthritis, Rheumatoid	A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls.
lncRNA target	34184082	hsa-mir-34c	Arthritis, Rheumatoid	A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls.
lncRNA target	34184082	hsa-mir-373	Arthritis, Rheumatoid	A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls.
lncRNA target	34184082	hsa-mir-766	Arthritis, Rheumatoid	A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls.
circulation_biomarker_diagnosis_up	34184078	hsa-mir-106a	Parkinson Disease	The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD.
circulation_biomarker_diagnosis_up	34184078	hsa-mir-29a	Parkinson Disease	The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD.
circulation_biomarker_diagnosis_up	34184078	hsa-mir-103a	Parkinson Disease	The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD.
circRNA target	34184075	hsa-mir-654	Carcinoma, Hepatocellular	In conclusion, interference with circRNA DOCK1 inhibited proliferation, invasion and migration of HCC cells by regulating the miR6545p/SMAD2 axis.
lncRNA target	34183954	hsa-mir-125b	Laryngeal Neoplasms	Down regulation of lncRNA MALAT1 inhibits laryngocarcinoma proliferation and invasion by modulating miR-125b/HMGA1. CONCLUSION: LncRNA MALAT1 promotes the development of laryngocarcinoma by regulating the expression level of HMGA1 by acting as a miR-125b ceRNA and may be considered as a new strategy for the development of laryngocarcinoma.
circulation_biomarker_prognosis_ns	34183951	hsa-mir-497	Intracranial Arteriosclerosis	miR-497 expression rises in ATCI patients, so this miR is expected to become a serum diagnostic marker for ATCI.
other	34183927	hsa-mir-451a	Prostatic Neoplasms	Conclusion miR-451a is lowly expressed in prostate cancer, and patients with low expression have a poor prognosis.
exosome	34183076	hsa-mir-622	Colorectal Neoplasms	CONCLUSION: Hsa_circ_0000231 attenuated Sev-aroused repression impacts on CRC development by sponging miR-622.
transcription factor target	34183039	hsa-mir-195	Intervertebral Disc Degeneration	CONCLUSION: MiR-195 was significantly upregulated in NP tissues of IVDD patients, and inhibition of miR-195 could protect human NP cells from TNF-alpha-induced apoptosis via upregulation of Bcl-2.
genetics_knock down_promote	34183035	hsa-mir-107	Osteoarthritis	RESULTS: HOTAIR expression was enhanced, and miR-107 level was reduced in OA cartilage samples. CONCLUSION: HOTAIR knockdown promoted chondrocyte proliferation, but inhibited cell apoptosis and ECM degradation in OA chondrocytes by regulating the miR-107/CXCL12 axis.
circRNA target	34182990	hsa-mir-29b	Stomach Neoplasms	CONCLUSIONS: Elevated circRNA_100290 expression in GC promotes cell proliferation, invasion and EMT via the miR-29b-3p/ITGA11 axis and might be regulated by EIF4A3.
lncRNA target	34182945	hsa-mir-21	Triple Negative Breast Neoplasms	CONCLUSION: Therefore, BRE-AS1 may inhibit TNBC by downregulating miR-21.
other	34182814	hsa-mir-615	Cholangiocarcinoma	5p/AMOT/YAP pathway, which may be a novel CCA pathway.
genetics_overexpression_promote	34182107	hsa-mir-8	Death	Overexpression of miR-8 in the CA increased cell size of the gland and expression of Jhamt (a gene coding for a key regulatory enzyme in JH biosynthesis), resulting in pupal lethality. By contrast, sponge-mediated reduction of miR-8 in the CA decreased cell size and Jhamt expression, but did not cause lethality.
genetics_overexpression_promote	34182107	hsa-mir-8	Perinatal Death	Overexpression of miR-8 in the CA increased cell size of the gland and expression of Jhamt (a gene coding for a key regulatory enzyme in JH biosynthesis), resulting in pupal lethality.
other	34182078	hsa-mir-132	Testicular Damage	Hippo pathway, which is highly conservative and may be activated by miR132 and miR195a, can control organ size and tissue regeneration, and participate in injury and deformity.
other	34182078	hsa-mir-195a	Testicular Damage	Hippo pathway, which is highly conservative and may be activated by miR132 and miR195a, can control organ size and tissue regeneration, and participate in injury and deformity.
circulation_biomarker_diagnosis_ns	34181969	hsa-mir-486	Acute Kidney Injury	5p mimic increased its levels in proximal tubules and endothelial cells, and improved plasma creatinine, histological injury, neutrophil infiltration, and apoptosis.
other	34181894	hsa-mir-519c	Inflammation	Furthermore, human placentas from normal and inflammation-associated pregnancies demonstrated that a decreased placental microRNA-519c level was linked to infection-induced inflammatory pathologies during pregnancy.
other	34181894	hsa-mir-519c	Premature Birth	CONCLUSION: We identified microRNA-519c, a human placenta-specific microRNA, as a novel regulator of immune adaptation associated with infection-induced preterm birth at the maternal-fetal interface. Our study serves as a basis for future experiments to explore the potential use of microRNA-519c as a biomarker for infection-induced preterm birth.
lncRNA target	34181826	hsa-mir-198	Ovarian Neoplasms	CONCLUSION: MiR-198 may possess an ability to inhibit activation of the P13K/Akt pathway, thus suppressing the OC cell proliferation, migration, as well as invasion.
circulation_biomarker_diagnosis_up	34181356	hsa-mir-148a	Carcinoma, Non-Small-Cell Lung	This study aimed to evaluate the role of serum miR-148a as a non-invasive biomarker in non-small cell lung cancer (NSCLC) patients and to assess the correlation between miR-148a and Bcl-2, as one of its target proteins. RESULTS: Significant lower expression of serum miR-148a and higher serum Bcl-2 levels were observed in NSCLC patients as compared to the control group (p.
other	34181233	hsa-mir-18a	Myocardial Infarction	Transfection of miR-18a-5p under ISO reduced the protective effect of 1% ISO against myocardial cell damage.
lncRNA target	34181232	hsa-mir-543	Triple Negative Breast Neoplasms	CONCLUSIONS: miR-543 influences the biological behavior of TNBC cells by directly targeting ACTL6A gene.
genetics_overexpression_promote	34181173	hsa-mir-17	Glioma	5p overexpression mitigated glioma progression, which was significantly inhibited with Circ-TLK1 upregulation.
genetics_overexpression_promote	34180760	hsa-mir-183	Nervous System Diseases	This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine.
genetics_overexpression_promote	34180758	hsa-mir-141	Carcinoma, Endometrioid	The overexpression of miR
circRNA target	34180753	hsa-mir-1205	Breast Neoplasms	In conclusion, our study suggests that circRASSF2 regulates BC progression through the miR-1205/HOXA1 pathway.
circulation_biomarker_prognosis_ns	34180348	hsa-mir-155	Ischemic Stroke	Serum miR-155 demonstrated a favorable function in predicting the development and prognosis of CIS (P < 0.001).
other	34180329	hsa-mir-199	Prostatic Diseases	Hsa-miR-143 and hsa-miR-199 were among the most prominent of the differentially expressed miRNAs upregulated in samples with prostate pathology but not vasectomy.
other	34180329	hsa-mir-143	Prostatic Diseases	Hsa-miR-143 and hsa-miR-199 were among the most prominent of the differentially expressed miRNAs upregulated in samples with prostate pathology but not vasectomy.
other	34180127	hsa-mir-29b-2	Pulmonary Fibrosis	Further, the ectopic expression of miR-29b5p and miR-34c-3p with chemotherapy attenuated silica-induced pulmonary fibrosis in vivo.
other	34180127	hsa-mir-34c	Pulmonary Fibrosis	Further, the ectopic expression of miR-29b5p and miR-34c-3p with chemotherapy attenuated silica-induced pulmonary fibrosis in vivo.
lncRNA target	34180119	hsa-mir-17	Acute Lung Injury	Taken together, our results indicate that HOTAIR regulated apoptosis, the cell cycle, proliferation and autophagy through the miR5p/ATG2/ATG7/ATG16 axis, thus driving LPS-induced ALI.
genetics_overexpression_suppress	34180077	hsa-mir-140	Breast Neoplasms	3p overexpression and syndecan-4 silencing increased the adhesion of BC to fibronectin and laminin.
circulation_biomarker_diagnosis_down	34179516	hsa-mir-1914	Cardiovascular Diseases	The expression of circulating miR5p is reportedly downregulated in patients with cardiovascular diseases.
other	34179503	hsa-mir-141	Uterine Cervical Neoplasms	The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively.
other	34179503	hsa-mir-340	Uterine Cervical Neoplasms	The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively.
lncRNA target	34179313	hsa-mir-200	Carcinoma, Hepatocellular	The expression profile of microRNA-200 (miR-200) families is different in hepatocellular carcinoma. miR-200 and their downstream genes might be the potentially specific targets for the treatment of hepatocarcinoma.
lncRNA target	34179092	hsa-mir-1827	Ovarian Neoplasms	Conclusion: These integrated bioinformatic analyses indicated that miRNA-1827 was dramatically downregulated in ovarian cancer as a tumor suppressor. Thus, the present study has identified miRNA-1827 as a potential intervention target for ovarian cancer based on our bioinformatic analysis processes.
circulation_biomarker_diagnosis_ns	34179081	hsa-mir-19a	Breast Neoplasms	plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients.
circulation_biomarker_diagnosis_ns	34179081	hsa-mir-126	Breast Neoplasms	plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients.
circulation_biomarker_diagnosis_ns	34179081	hsa-mir-20a	Breast Neoplasms	plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients.
circulation_biomarker_diagnosis_ns	34179081	hsa-mir-10b	Breast Neoplasms	plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients.
circulation_biomarker_diagnosis_ns	34179081	hsa-mir-155	Breast Neoplasms	plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients.
target gene	34178988	hsa-mir-186	Stomach Neoplasms	LncRNA HCP5 Induces Gastric Cancer Cell Proliferation, Invasion, and EMT Processes Through the miR-186-5p/WNT5A Axis Under Hypoxia.
genetics_overexpression_suppress	34178974	hsa-mir-124	Cleft Palate	Among them, overexpression of miR-27a-3p, miR-27b-3p, and miR
lncRNA target	34178725	hsa-mir-548d	American Tegumentary Leishmaniasis	As miR-548d-3p was predicted to target the chemokine pathway and inflammation is a central to the pathogenesis of ATL, we evaluated the effect of transient transfection of a miR-548d-3p inhibitor on L. Our data suggest miR-548d-3p could be further evaluated as a prognostic marker for ATL and/or as a host-directed therapeutic target.
lncRNA target	34178725	hsa-mir-548d	Inflammation	As miR-548d-3p was predicted to target the chemokine pathway and inflammation is a central to the pathogenesis of ATL, we evaluated the effect of transient transfection of a miR-548d-3p inhibitor on L. Our data suggest miR-548d-3p could be further evaluated as a prognostic marker for ATL and/or as a host-directed therapeutic target.
other	34178670	hsa-mir-1271	Colorectal Neoplasms	3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction.
other	34178670	hsa-mir-130a	Colorectal Neoplasms	3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction.
other	34178670	hsa-mir-495	Colorectal Neoplasms	3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction.
other	34178670	hsa-mir-130b	Colorectal Neoplasms	3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction.
target gene	34178650	hsa-mir-193b	Uterine Cervical Neoplasms	N(6)-Methyladenosine Associated Silencing of miR-193b Promotes Cervical Cancer Aggressiveness by Targeting CCND1.
other	34178135	hsa-mir-142	Stomach Neoplasms	Long non-coding RNA NEAT1 increases the aggressiveness of gastric cancer by regulating the microRNA-142-5p/JAG1 axis.
exosome	34178037	hsa-mir-150	Endometrial Fibrosis	CONCLUSION: ADSC-Exos mediate lncRNA-MIAT alleviation of endometrial fibrosis by regulating miR5p, which suggests that lncRNA-MIAT from ADSC-Exos may be a viable treatment for endometrial fibrosis.
lncRNA target	34178027	hsa-mir-874	Intervertebral Disc Degeneration	Functionally, circ_0040039 could enhance NPC apoptosis and inhibit NPC growth, revealing that circ_0040039 might aggravate IDD by stabilizing miR
other	34177591	hsa-mir-489	Stomach Neoplasms	Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer.
other	34177568	hsa-mir-34a	Myocardial Infarction	CONCLUSION: RSV rejuvenated BMSCs after chronic hyperglycemia-induced senescence by interacting with miR-34a and optimized the therapeutic effect of BMSCs on diabetes with myocardial infarction.
transcription factor target	34177264	hsa-mir-9	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Our study suggests that inhibition of miR3p protects against cerebral I/R injury through activating GSK-3beta/Nrf2/ARE signaling-mediated antioxidant responses by targeting FGF19, providing a potential therapeutic target for ischemic stroke.
lncRNA target	34176781	hsa-mir-637	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Downregulation of miR-637 in NSCLC was associated with TNM stage and poor prognosis of patients and served as a tumor suppressor in NSCLC.
lncRNA target	34176471	hsa-mir-4306	Thyroid Cancer, Papillary	CONCLUSION: ILF3-AS1 plays tumor-promoting role in PTC via targeting miR-4306/PLAGL2 axis.
exosome	34176265	hsa-mir-155	Squamous Cell Carcinoma of Head and Neck	Taken together, our findings, for the first time, established that the miR-155 inhibitor-loaded exosomes reverse chemoresistance in oral cancer, thereby providing an alternative therapeutic strategy for the management of refractory oral cancer patients.
other	34175436	hsa-mir-142	Tuberculosis	3p and the LASSO cox prediction model based on HMGA1 and CAPN1 have potential value for forecasting TB (AUC > 0.7).
other	34175436	hsa-mir-140	Tuberculosis	3p and the LASSO cox prediction model based on HMGA1 and CAPN1 have potential value for forecasting TB (AUC > 0.7).
other	34175401	hsa-mir-200a	Ovarian Neoplasms	Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly.
other	34175401	hsa-mir-130a	Ovarian Neoplasms	Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly.
other	34175401	hsa-mir-21	Ovarian Neoplasms	Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly.
lncRNA target	34175330	hsa-mir-126	Diabetes Mellitus	Therefore, regulatory processes through mir-126, which are influenced by aerobic exercise, can be a valuable strategy in developing new treatments for diabetes.
circulation_biomarker_prognosis_ns	34175168	hsa-mir-93	Carcinoma, Hepatocellular	CONCLUSIONS: Plasma and urine miR
other	34175151	hsa-mir-371a	Testicular Germ Cell Tumor	Levels of miR-371a-3p correlate with primary tumour mass, clinical stage, and International Germ Cell Cancer Collaborative Group risk groups.
circulation_biomarker_diagnosis_ns	34175151	hsa-mir-367	Testicular Germ Cell Tumor	OBJECTIVE: To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular GCTs in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation.
circulation_biomarker_diagnosis_ns	34175151	hsa-mir-371	Testicular Germ Cell Tumor	OBJECTIVE: To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular GCTs in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation.
lncRNA target	34174974	hsa-mir-665	Stomach Neoplasms	In gastric cancer tissues and cells, the expression of circSFMBT2 was up-regulated, and the expression of miR-665 was down-regulated. It was concluded that paeonol can inhibit the proliferation, migration, invasion and glutamine decomposition of gastric cancer HGC-27 cells via circSFMBT2/miR-665 axis, and also induce cell apoptosis.
other	34174955	hsa-mir-205	Diabetic Nephropathies	CONCLUSION: All data have manifested that circ-ACTR2 contributed to the HG-induced DN progression in HRMCs by the mediation of miR5p/HMGA2 axis.
lncRNA target	34174908	hsa-mir-181a	Endometrial Neoplasms	DLEU2 acted as an upstream activator for HK2-induced EMT and glycolysis in EC cells through two distinct mechanisms: (i) DLEU2 induced HK2 expression by competitively binding with miR-455, and (ii) DLEU2 also interacted with EZH2 to silence a direct inhibitor of HK2, miR-181a.
lncRNA target	34174908	hsa-mir-455	Endometrial Neoplasms	DLEU2 acted as an upstream activator for HK2-induced EMT and glycolysis in EC cells through two distinct mechanisms: (i) DLEU2 induced HK2 expression by competitively binding with miR-455, and (ii) DLEU2 also interacted with EZH2 to silence a direct inhibitor of HK2, miR-181a.
circulation_biomarker_diagnosis_up	34174519	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	RESULTS: Exosomal miR-155 and miR-21 were significantly upregulated, and exosomal miR-126 was dramatically downregulated in the primary OSCC cells and the serum of OSCC patients. CONCLUSION: Exosomal miR-155 and miR-21 are oncogenic miRNAs which suppress PTEN and Bcl-6 expression, and exosomal miR-126 acts as a tumor suppressor which downregulates EGFL7 in OSCC.
circulation_biomarker_diagnosis_up	34174519	hsa-mir-155	Squamous Cell Carcinoma of Head and Neck	RESULTS: Exosomal miR-155 and miR-21 were significantly upregulated, and exosomal miR-126 was dramatically downregulated in the primary OSCC cells and the serum of OSCC patients. CONCLUSION: Exosomal miR-155 and miR-21 are oncogenic miRNAs which suppress PTEN and Bcl-6 expression, and exosomal miR-126 acts as a tumor suppressor which downregulates EGFL7 in OSCC.
lncRNA target	34174438	hsa-mir-122	Brain Injuries	5p administration may be an attractive therapeutic target in RBI, providing new insights for clinical trials.
lncRNA target	34173813	hsa-mir-125b	Myocardial Infarction	The rat model also indicated that Carv might suppress the progression of acute myocardial infarction by regulating the levels of circ_NFIX, miR-125b-5p, and TLR4.
other	34173804	hsa-mir-106a	Myocardial Reperfusion Injury	In patients with acute myocardial infarction and in H/R cardiomyocytes and ischemia/reperfusion myocardium, the expression levels of FGD5-AS1 were reduced, whereas the expression levels of miR-106a-5p and miR-106b-5p were increased.
other	34173804	hsa-mir-106b	Myocardial Reperfusion Injury	In patients with acute myocardial infarction and in H/R cardiomyocytes and ischemia/reperfusion myocardium, the expression levels of FGD5-AS1 were reduced, whereas the expression levels of miR-106a-5p and miR-106b-5p were increased.
circulation_biomarker_diagnosis_ns	34173728	hsa-mir-20a	Ischaemic Heart Disease	5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05).
circulation_biomarker_diagnosis_ns	34173728	hsa-mir-20a	Cardiomyopathy, Dilated	5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05).
circulation_biomarker_diagnosis_ns	34173728	hsa-mir-29	Ischaemic Heart Disease	5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05).
circulation_biomarker_diagnosis_ns	34173728	hsa-mir-29	Cardiomyopathy, Dilated	5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05).
other	34173712	hsa-mir-525	Triple Negative Breast Neoplasms	In conclusion, LINC01234 aggravated TNBC cell growth, migration, invasion and EMT by modulating the miR5p/MEIS2 axis and activating the Wnt/beta-catenin signaling pathway.
lncRNA target	34173673	hsa-mir-433	Myocardial Reperfusion Injury	Thus, our findings indicate that NOB could effectively relieve H/R-induced damage in H9c2 cells by modulating the miR-433/SIRT1 axis, suggesting that nobiletin may be a potential drug for the treatment of myocardial ischemia-reperfusion injury. Furthermore, this study also identified another potential therapeutic target, miR-433, for the treatment of myocardial ischemia-reperfusion injury.
genetics_GWAS	34172780	hsa-mir-146a	Sepsis	Taken together, these results demonstrated that the 29940 G-to-C mutation within the NLRP3 3'-UTR was a gain-of-function alteration that caused the suppression of NLRP3 expression and downstream inflammatory cytokine production via binding with miR-146a, which ultimately protected patients against susceptibility to sepsis progression and poor clinical outcome.
circulation_biomarker_diagnosis_ns	34171684	hsa-mir-155	Multiple Sclerosis, Relapsing-Remitting	The study aims at investigating the expression of miR-155, ICAM1, ITGB2, perforin and GranzymeB in CD8+ T cells of RRMS patients receiving different treatment regimens and how these genes correlate with patients' EDSS and miR-155 expression. METHODS: Gene expression of miR-155, ICAM1, ITGB2, perforin and granzymeB was evaluated using RT-qPCR in CD8+ T cells isolated from blood samples of RRMS patients and compared to healthy controls.
lncRNA target	34171541	hsa-mir-379	Glioma	5p could regulate glioma cell viability, migration, invasion and EMT through MGST1, suggesting that miR
genetics_overexpression_promote	34171521	hsa-mir-101	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	MiR-101 mimic inhibited viability, migration and invasion of T-ALL cells, and reversed effects of overexpressed LINC00665, whilst miR-101 inhibitor reversed the effects of LINC00665 silencing.
lncRNA target	34171363	hsa-mir-424	Coronary Disease	Taken together, this study demonstrated that THRIL inhibition alleviates myocardial injury in CHD possibly through the miR-424/TXNIP/p53 axis.
transcription factor target	34170852	hsa-mir-143	Prostatic Neoplasms	ZQD treatment could promote apoptosis of prostate cancer cells by promoting miR-143 upregulation, which could be a possible mechanism underlying the inhibitory effect of ZQD in prostate cancer in patient.
genetics_overexpression_promote	34170494	hsa-mir-28	Carcinoma, Renal Cell	5p activity or overexpressing HMGA1, indicating that ITGB2-AS1 promotes the survival and progression of ccRCC by modulating miR
lncRNA target	34170484	hsa-mir-885	Cholangiocarcinoma	5p/MTPN axis may serve as a target for improving the sensitivity of CCA cells to chemotherapy.
genetics_overexpression_promote	34170291	hsa-mir-224	Colorectal Neoplasms	5p increased the proliferative, migratory and invasive abilities of CRC cells and inhibit CRC cell apoptosis, while overexpressing SLC4A4 caused the opposite result.
genetics_overexpression_suppress	34170070	hsa-mir-1	Colorectal Neoplasms	Overexpression or inhibition of miRNA-31 further confirmed the change in its expression in colorectal cancer cell lines.
other	34169968	hsa-mir-185	Tuberculosis	Eventually, miR5p was collected as a promising potential biomarker for tuberculosis.
other	34169732	hsa-mir-95	Colorectal Neoplasms	five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p.
other	34169732	hsa-mir-145	Colorectal Neoplasms	five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p.
other	34169732	hsa-mir-139	Colorectal Neoplasms	five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p.
other	34169732	hsa-mir-1247	Colorectal Neoplasms	five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p.
other	34169732	hsa-mir-429	Colorectal Neoplasms	five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p.
lncRNA target	34169675	hsa-mir-411	Prostatic Neoplasms	5p inhibits PCa progression.
circRNA target	34169652	hsa-mir-326	Atherosclerosis	In conclusion, circ_0002984 mediated cell proliferation, migration and inflammation through modulating miR3p and VAMP3 in VSMCs, which suggested that circ_0002984 might hold great promise as a therapeutic strategy for atherosclerosis.
lncRNA target	34169384	hsa-mir-181b	Cholangiocarcinoma	The present data indicated miR-181b-5p acted as an oncogene in CCA through promoting tumor cell proliferation, migration, and invasion of CCA via the PTEN/PI3K/AKT signaling pathway by targeting PARK2, which might be a promising therapeutic target or biomarker for CCA.
lncRNA target	34169096	hsa-mir-592	Uterine Cervical Neoplasms	Importantly, functional research findings indicated that lncRNA MEF2C-AS1 inhibited CC via suppressing miR-592 by targeting RSPO1.
target gene	34169001	hsa-mir-27	Triple Negative Breast Neoplasms	miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase.
other	34168984	hsa-mir-136	Wilms Tumor	In conclusion, our study discovered the biological role of the circ0093740-miR-136/145-DNMT3A axis in Wilms tumor growth and metastasis which is important for developing new treatment strategy.
other	34168917	hsa-mir-296	Carcinoma, Hepatocellular	5p) to positively modulate E2F transcription factor 2 (E2F2) and SRY-box transcription factor 12 (SOX12) in HCC cells.
lncRNA target	34168916	hsa-mir-593	Glioblastoma	We demonstrated that circMELK was upregulated in GBM, acting as an oncogene and regulating GBM mesenchymal transition and GSC maintenance via sponging of miR-593. Furthermore, we found that EphB2 was involved in circMELK/miR-593 axis-induced GBM tumorigenesis.
other	34168648	hsa-mir-215	Tuberculosis	A decision-tree algorithm identified gamma-glutamylthreonine and hsa-miR5p as the optimal variables to classify incident TB cases (AUC 0.965; 95% CI 0.925-1.000).
other	34168648	hsa-mir-215	Acquired Immunodeficiency Syndrome	A decision-tree algorithm identified gamma-glutamylthreonine and hsa-miR5p as the optimal variables to classify incident TB cases (AUC 0.965; 95% CI 0.925-1.000).
transcription factor target	34168462	hsa-mir-145	Melanoma	Furthermore, BGM inhibited the progression of melanoma by targeting miR-145/Cyclin D1 axis in vitro.
circulation_biomarker_diagnosis_up	34168120	hsa-mir-217	Pancreatic Carcinoma	Subsequently, miR-217 suppressed PC cell proliferation and metastasis by directly targeting YWHAG, which interacted with RAF1 and promoted its phosphorylation, leading to RAF1-mediated ERK signaling activation and translocation of phosphorylated ERK from the cytoplasm to the nucleus.
lncRNA target	34168116	hsa-mir-510	Carcinoma, Pancreatic Ductal	Collectively, present findings reveal that circSLIT2/miR5p/c-Myc/LDHA axis participates in the aerobic glycolysis and carcinogenesis of PDAC, and may act as a promising therapeutic target.
other	34167625	hsa-mir-424	Solitary Pulmonary Nodule	sEVs-miR5p could be a novel biomarker for distinguishing SSN from LC and BN populations.
other	34167624	hsa-mir-147	Squamous Cell Carcinoma of Head and Neck	In conclusion, this study found that IRX5 plays a role in promoting cancer in OSCC, and IRX5 is also negatively regulated by miRNA-147.
circulation_biomarker_diagnosis_ns	34167618	hsa-mir-155	Primary Myelofibrosis	The proposed novel fluorescent probe based on the DSN can be used to detect miRNA-155 in human serum and provide a potential, convenient and reliable tool for diagnosis of MM.
other	34167618	hsa-mir-155	Multiple Myeloma	MicroRNA-155 (miRNA-155) as a characteristic myeloma-associated biomarker exhibits significant potential application in the diagnosis of multiple myeloma (MM).
transcription factor target	34167441	hsa-mir-9	Leukemia, Myeloid	Taken together, miR-9 may act as a tumor suppressor by activating the Hippo/YAP signaling pathway of AML cells, which in this way supply ideas for the clinical remedy of AML patients.
transcription factor target	34167441	hsa-mir-9	Ischemic Stroke	Taken together, miR-9 may act as a tumor suppressor by activating the Hippo/YAP signaling pathway of AML cells, which in this way supply ideas for the clinical remedy of AML patients.
genetics_overexpression_promote	34167436	hsa-mir-4486	Stomach Neoplasms	miR-4486 overexpression could decrease viability and improve apoptosis of SGC-7901/DDP cells to revert its cisplatin-resistance, and the mechanism may be related to JAK3/STAT3 signalling pathway.
other	34166944	hsa-mir-21	Breast Neoplasms	As a proof of concept, the self-assembled AuAg NCs is successfully applied in the ultrasensitive detection of breast cancer biomarker microRNAs-21 (miR-21), which guides a new pathway for creating high-quality nano-optical elements in chemical sensors, biological imaging, and lightemitting devices.
exosome	34166712	hsa-mir-143	Myocardial Reperfusion Injury	SIGNIFICANCE: Collectively, our results indicated that MSCs-derived exosomal miR3p might represent a promising option for the treatment of I/R injury.
circulation_biomarker_diagnosis_ns	34165827	hsa-mir-498	Osteoarthritis	RESULTS: RUNX2-derived hsa_circ_0005526 (circ_RUNX2) is significantly highly expressed in OA serum and mainly located in the cytoplasm within the cartilage cell by sponging multiple miRNAs (miR-498, miR-924, miR3p, and miR-665).
circulation_biomarker_diagnosis_ns	34165827	hsa-mir-924	Osteoarthritis	RESULTS: RUNX2-derived hsa_circ_0005526 (circ_RUNX2) is significantly highly expressed in OA serum and mainly located in the cytoplasm within the cartilage cell by sponging multiple miRNAs (miR-498, miR-924, miR3p, and miR-665).
other	34165388	hsa-mir-152	Sepsis	3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC.
other	34165388	hsa-mir-152	Acute Lung Injury	3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC.
circRNA target	34165176	hsa-mir-619	Thyroid Cancer, Papillary	From these analyses, one PTCrelated miRNA (hsamiR36195p) was identified as a potential target for hsa_circ_IPCEF1 sponging, indicating the hsa_circ_IPCEF1/hsamiR36195p axis in pathogenesis.
genetics_overexpression_suppress	34165171	hsa-mir-486	Nasopharyngeal Carcinoma	Finally, the effects of SLC9A3AS1 silencing on NPC cells were reversed by inhibiting miR4865p or overexpressing E2F6. In summary, SLC9A3AS1 exerted carcinogenic effects on NPC cells by adjusting the miR4865p/E2F6 axis.
lncRNA target	34165168	hsa-mir-10b	Lung Neoplasms	These findings indicate a novel pathway in which cisplatin induces the levels of p53 by increasing mRNA stability via miR10b, indicating a novel oncogenic role of miR10b in promoting the malignant characteristics of nonsmall cell lung carcinoma.
lncRNA target	34165162	hsa-mir-223	Seizures, Febrile	Therefore, the results from the present study collectively suggested that treatment with MT alleviated FC via the MEG3/miR223/PTEN/AKT pathway, which also indicated that MT could be considered as a novel strategy for the treatment of FC disease.
lncRNA target	34165160	hsa-mir-205	Lung Neoplasms	Reverse transcriptionquantitative PCR was performed, which determined that miR205 expression was upregulated in NSCLC, and the present study detected the upregulation of miR2053p in a number of NSCLC cell lines and NSCLC tissues. Thus, the current findings highlighted the potential promotive impact of miR2053p on NSCLC processes and may provide theoretical evidence for miR2053p as a potential clinical gene therapy target.
other	34165154	hsa-mir-148a	Atherosclerosis	The present study aimed to investigate the role of the Kruppellike factor 5 (KLF5)/LINC00346/miR148a3p loop in AS.
genetics_overexpression_suppress	34165008	hsa-mir-126	Arthritis, Rheumatoid	In addition, overexpression of miR
genetics_knock down_promote	34164963	hsa-mir-495	Osteoarthritis	SOX9 was downregulated in the damaged cartilage tissues of patients with OA, and knockdown of SOX9 abolished the effect of anti-miR-495 on IL-1beta-treated TC28a2 cells.
other	34164962	hsa-mir-144	Squamous Cell Carcinoma of Head and Neck	3p expression and increasing EZH2 expression.
lncRNA target	34164910	hsa-mir-21	Pulmonary Fibrosis	However, whether miR-21 mediates obstructive renal fibrosis through the same signalling pathway has not been determined.
other	34164896	hsa-mir-1200	Alcoholism	Among these, circRNA-406742 and miR-1200 significantly interact with the highest number of mRNA, including genes associated with neuronal functioning and alcohol addiction (HRAS, PRKCB, HOMER1, and PCLO).
genetics_knock down_suppress	34164774	hsa-mir-340	Osteosarcoma	In conclusion, circ-CHI3L1.2 levels were increased in cisplatin-resistant osteosarcoma cells and circ-CHI3L1.2 knockdown sensitized cisplatin-resistant osteosarcoma cells to cisplatin through the miR5p-LPAATbeta axis.
lncRNA target	34164767	hsa-mir-942	Thyroid Neoplasms	Overall, silencing of hsa_circ_0001681 significantly suppressed TC progression through inhibiting EMT via acting as a miR
genetics_overexpression_promote	34164498	hsa-mir-211	Cicatrix, Hypertrophic	5p could target TGFbetaR2 (all P<0.05), and when hHSFs cells simultaneously overexpressed miR
lncRNA target	34164494	hsa-mir-637	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: CircHIPK3 demonstrates potential as a prognostic marker of OSCC and mediates OSCC progression via the miRmediated NUPR1/PI3K/AKT axis.
genetics_overexpression_promote	34164486	hsa-mir-664a	Polycystic Ovary Syndrome	Moreover, our results confirmed that miR-664a-3p directly targets BCL2A1 (P<0.05), and the inhibitory effect of miR-664a-3p on KGN cells was reversed by BCL2A1 overexpression (both P<0.05).
other	34164485	hsa-mir-216a	Parkinson Disease	Long non-coding RNA SNHG1 mediates neuronal damage in Parkinson's disease model cells by regulating miR-216a-3p/Bcl-2-associated X protein.
genetics_knock down_promote	34164475	hsa-mir-758	Osteosarcoma	In OS cells, migration, invasion, and epithelial-mesenchymal transformation (EMT) was promoted by overexpression of XIST and miR-758 inhibitor, but were inhibited by XIST knockdown and miR-758 mimics.
circulation_biomarker_diagnosis_up	34164201	hsa-mir-146a	Acute Coronary Syndrome	CONCLUSIONS: The serum exo-miR-146a may be used as a novel diagnostic biomarker for ACS patients, and it is also associated with inflammatory response.
circulation_biomarker_prognosis_up	34163524	hsa-mir-1246	Carcinoma, Hepatocellular	The expression levels of serum miR-497 and miR-1246 were significantly associated with the diagnosis, prognosis, and overall survival rate of patients with HCC.
genetics_overexpression_promote	34163467	hsa-mir-186	Myocardial Infarction	Concludingly, the overexpression of TUG1 alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through targeting the miR
genetics_overexpression_promote	34163467	hsa-mir-186	Cardiomyopathies	Concludingly, the overexpression of TUG1 alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through targeting the miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-23a	Sarcopenia	In aging patients, plasma miR-23a-3p, miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-93	Sarcopenia	In aging patients, plasma miR-23a-3p, miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-637	Fractures, Bone	In aging patients, plasma miR-23a-3p, miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-23a	Fractures, Bone	In aging patients, plasma miR-23a-3p, miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-93	Fractures, Bone	In aging patients, plasma miR-23a-3p, miR
circulation_biomarker_diagnosis_up	34163374	hsa-mir-637	Sarcopenia	In aging patients, plasma miR-23a-3p, miR
other	34163215	hsa-mir-637	cervical squamous cell carcinoma	miR-637 and RXRB mRNA expression levels in CSCC patients were examined using quantitative PCR. CONCLUSION: These findings suggest that the rs2072915 T > A change might augment the binding energy of miR-637 to RXRB, result in lower levels of RXRB, and thus contribute to the risk of CSCC.
lncRNA target	34163177	hsa-mir-544b	Carcinoma, Hepatocellular	This study clarified the role of MEG3/miR-544b/BTG2 axis in HCC and also provided new targets for HCC research.
target gene	34163175	hsa-mir-593	Prostatic Neoplasms	miR-593-3p Promotes Proliferation and Invasion in Prostate Cancer Cells by Targeting ADIPOR1.
transcription factor target	34163033	hsa-mir-142	Ovarian Neoplasms	Taken together, our findings unveil a novel homeostatic loop of SRI that drives the PTX-resistance and malignant progression via Smad4/ZEB1/miR5p in human OC.
lncRNA target	34162830	hsa-mir-127	Stomach Neoplasms	5p-SORT1 pathway, and our study provides novel insight for the identification of diagnostic/prognostic biomarkers and therapeutic targets for GC.
transcription factor target	34162761	hsa-mir-27b	Stomach Neoplasms	miR-27b-3p was confirmed with the binding site with PAX4 using ChIP assay and served as a tumor suppressor that inhibiting GC cell growth and metastasis, and reversed the effect of PAX4. Taken together, the PAX4/miR-27b-3p/Grb2 loop is known to be involved in GC cell promotion, and can be seen as a promising target for GC therapy.
lncRNA target	34162562	hsa-mir-98	Esophageal Squamous Cell Carcinoma	5p, in the treatment of esophageal squamous cell carcinoma.
lncRNA target	34162560	hsa-mir-93	Pancreatic Carcinoma	5p modulates tumorigenesis and gemcitabine resistance in PC cells via targeting the PTEN/PI3K/Akt signaling pathway.
lncRNA target	34162557	hsa-mir-132	Breast Neoplasms	3p enhanced VP16-induced breast cancer cell apoptosis through targeting GSK3B.
circulation_biomarker_diagnosis_ns	34162296	hsa-mir-28	Carotid Stenosis	RESULTS: Serum miR
lncRNA target	34162150	hsa-mir-140	Osteoarthritis	5p effectively alleviate EOA progression by modulating multiple biological processes and pathways in rats, representing a promising therapeutic for EOA.
lncRNA target	34162147	hsa-mir-223	Sepsis	meditated M2-type polarization of macrophages via targeting to Nfat5 and Rasa1 to control the progress of sepsis.
genetics_overexpression_promote	34161651	hsa-mir-19a	Renal Insufficiency, Chronic	This study tested the hypothesis that therapy with double overexpression of miR-19a-3p and miR-20a-5p (miR(DOE) ) to human inducible pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) was superior to iPS-MSCs alone for preserving renal function in rat with pre-existing chronic kidney disease (CKD), followed by ischaemia-reperfusion (IR) injury.
genetics_overexpression_promote	34161651	hsa-mir-20a	Renal Insufficiency, Chronic	This study tested the hypothesis that therapy with double overexpression of miR-19a-3p and miR-20a-5p (miR(DOE) ) to human inducible pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) was superior to iPS-MSCs alone for preserving renal function in rat with pre-existing chronic kidney disease (CKD), followed by ischaemia-reperfusion (IR) injury.
lncRNA target	34161325	hsa-let-7	Inflammation	Let-7b is a member of the let-7 microRNA family and plays an inhibitory role in a variety of diseases and inflammatory conditions.
lncRNA target	34161325	hsa-let-7b	Fibrosis	CONCLUSION: Our research clarifies the role of let-7b in the inhibition of HSC activation by rSjP40 and will provide new insights and ideas for the inhibition of HSC activation and treatment of liver fibrosis.
lncRNA target	34161325	hsa-let-7b	Inflammation	Let-7b is a member of the let-7 microRNA family and plays an inhibitory role in a variety of diseases and inflammatory conditions.
genetics_overexpression_promote	34160894	hsa-mir-206	Osteoarthritis	Overexpressed Elf3 reversed miR-206 up-regulation-induced effects on OA osteoblasts.
lncRNA target	34160887	hsa-mir-27a	Ovarian Neoplasms	We demonstrated that downregulation of the short isoform of UCA1 sensitized OC cells to cisplatin and that UCA1 acted as competing endogenous RNA to miR-27a-5p. In conclusion, response to treatment in patients with OC is regulated by the UCA1/miR-27a-5p/UBE2N axis, where UBE2N inhibition could potentially represent a novel therapeutic strategy to counter chemoresistance in OC.
genetics_overexpression_promote	34160745	hsa-mir-137	Glioma	Additionally, EZH2 was a direct target of miR-137 and overexpressed EZH2 effectively reversed the effect of miR-137 on glioma proliferation and migration.
genetics_overexpression_promote	34160728	hsa-mir-483	Arthritis, Rheumatoid	Overexpressed miR
exosome	34160339	hsa-mir-142	Osteoarthritis	CONCLUSION: Exosomal PCGEM1 from OA-FLSs facilitated IL-1beta-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR
lncRNA target	34160338	hsa-mir-28	Stomach Neoplasms	3p inhibitor increased apoptosis and oxidative stress of human gastric cancer cells.
lncRNA target	34160186	hsa-mir-365	Infantile convulsions and paroxysmal choreoathetosis, familial	3p inhibited the differentiation of bMSCs into ICCs via targeting Pax6 and inhibiting the MEK/ERK pathway.
circulation_biomarker_diagnosis_up	34160076	hsa-mir-374b	Stomatitis	CONCLUSIONS: hsa-miR-374b-5p is upregulated in blood and ginvial cells exposed to oral inflammation and tobacco smoke and regulates UHMK1, which has a role in osteoclast differentiation.
lncRNA target	34159811	hsa-mir-142	Vitamin D Deficiency	3p, which suppresses autophagy.
lncRNA target	34159811	hsa-mir-142	Inflammatory Bowel Diseases	3p, which suppresses autophagy.
circulation_biomarker_diagnosis_ns	34159768	hsa-mir-29b	Pulmonary Disease, Chronic Obstructive	Firstly, miR-29b and interleukin (IL)-22 expression was assessed in serum of 20 healthy non-smokers, 20 healthy smokers and 20 COPD patients as well as CSE-treated HBE cells.
other	34159752	hsa-mir-891a	Melanoma	LINC02446, LINC01857, and LINC02384 may stimulate melanoma progression by reducing tumor-protecting miR.891a.5p and miR.203b.3p.
lncRNA target	34159524	hsa-mir-590	Fetal Growth Retardation	3p exhibits a growing trend during pregnancy, and its expression in middle and late pregnancy is associated with increased FGR risk via interaction with VEGF, PIGF, and MMP9.
genetics_knock down_suppress	34159436	hsa-mir-135b	Stomach Neoplasms	More importantly, blocking the SP1 function by Plicamycin, an SP1 inhibitor, abolished the effect of stable miR-135b-5p knockdown GC cell-derived exosomes on Vgamma9Vdelta2 T cell function. Collectively, our results suggest that GC cell-derived exosomes impair the function of Vgamma9Vdelta2 T cells via miR-135b-5p/SP1 pathway, and targeting exosomal miR-135b-5p/SP1 axis may improve the efficiency of GC immunotherapy based on Vgamma9Vdelta2 T cells.
other	34159082	hsa-mir-145	Penile Neoplasms	CONCLUSIONS: Our data suggest that the underexpression of miR-145 may be triggered by HPV action, decreasing protein expression of p53, and being correlated with perineural invasion.
exosome	34159078	hsa-mir-155	Prostatitis	CONCLUSIONS: Exosomes in the prostatic fluid and the miRNA-155 contained therein were may be involved with the pathogenesis of CP/CPPS-A.
other	34159075	hsa-mir-29c	Urinary Bladder Neoplasms	Moreover, the correlations between TTLL7 and resting mast cells (R=0.24, P<0.001), DSC2 and resting mast cells (R=-0.23, P<0.001), ELN and resting mast cells (R=0.44, P<0.001), and hsa-miR-29c-3p and M0 macrophages (R=-0.29, P<0.001) were significant, indicating that interactions of these factors may play significant roles in the prognosis of BC. CONCLUSIONS: TTLL7, DSC2, ELN, hsa-miR-29c-3p, resting mast cells, and M0 macrophages may play an important role in the development of BC.
other	34159074	hsa-mir-1193	Prostatic Neoplasms	Additionally, it causes PCa cells to proliferate by negatively regulating miR-1193.
other	34158869	hsa-mir-486a	Cardiomyopathies	Conclusions: Our study demonstrates that elevated IgE promotes pathological cardiac fibrosis by modulating miR-486a-5p and downstream factors, such as Smad1.
other	34158869	hsa-mir-486	Cardiomyopathies	Conclusions: Our study demonstrates that elevated IgE promotes pathological cardiac fibrosis by modulating miR-486a-5p and downstream factors, such as Smad1.
other	34158867	hsa-mir-375	Breast Neoplasms	Conclusion: Our findings identified a crucial role of LDHB in macrophages and established tumor-derived miR-375 as a novel regulator of macrophage metabolism in breast cancer, which might pave the way for strategies of combinatorial cancer cell/stroma cell interventions.
genetics_overexpression_promote	34158819	hsa-mir-196a	Thyroid Neoplasms	Our study results manifested that miR-196a-2 was dramatically overexpressed in cells of TC, while NRXN1 was lowly expressed.
genetics_overexpression_promote	34158819	hsa-mir-196a-2	Thyroid Neoplasms	Our study results manifested that miR-196a-2 was dramatically overexpressed in cells of TC, while NRXN1 was lowly expressed.
transcription factor target	34158627	hsa-mir-766	Colorectal Neoplasms	3p reduces the proliferation of CRC cells by targeting HNF4G expression and thus inhibits the PI3K/AKT pathway.
genetics_overexpression_promote	34158416	hsa-mir-24	Myocardial Infarction	Moreover, TOLLIP overexpression debilitated the promotive role of miR
lncRNA target	34158095	hsa-mir-152	Osteoarthritis	CONCLUSIONS: It was concluded that lncRNA CASC19 accelerated chondrocytes apoptosis and proinflammatory cytokine production to exacerbate osteoarthritis development through regulating the miR3p/DDX6 axis.
genetics_knock down_promote	34158077	hsa-mir-30	Prostatic Neoplasms	Moreover, overexpression of miR
lncRNA target	34157861	hsa-mir-193b	Metabolic Diseases	Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression.
lncRNA target	34157861	hsa-mir-193b	Heart Failure	Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression.
lncRNA target	34157861	hsa-mir-193b	Hypertension, Pulmonary	Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression.
genetics_knock down_promote	34157832	hsa-mir-338	Osteosarcoma	3p level in OS cells after knockdown of circRNA_103801 was elevated compared with the control group.
lncRNA target	34157472	hsa-mir-342	COVID-19	5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified.
lncRNA target	34157472	hsa-mir-432	COVID-19	5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified.
lncRNA target	34157472	hsa-mir-98	COVID-19	5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified.
lncRNA target	34157472	hsa-mir-17	COVID-19	5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified.
lncRNA target	34157350	hsa-mir-3180	Diabetes Mellitus, Type 2	5p targets could provide valuable information for the development of therapeutic drugs for type 2 diabetes.
lncRNA target	34157350	hsa-mir-4632	Diabetes Mellitus, Type 2	5p targets could provide valuable information for the development of therapeutic drugs for type 2 diabetes.
transcription factor target	34157155	hsa-mir-21	Liver Injury	Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation.
transcription factor target	34157155	hsa-mir-21	Cholestasis	Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation.
transcription factor target	34157155	hsa-mir-21	Diabetic Nephropathies	Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation.
other	34156885	hsa-mir-214	alpha-Thalassemia	In this study, we illustrated the expressions of miR-214 and ATF4 in Hb H (beta4) disease, and Hb E (HBB: c.79G>A)/beta-thalassemia (beta-thal) reticulocyte samples.
genetics_overexpression_promote	34156675	hsa-mir-150	Squamous Cell Carcinoma of Head and Neck	MiR-150 overexpression inhibited the abilities of viability, invasive and the EMT by targeting HMGA2 in OSCC cells.
transcription factor target	34156672	hsa-mir-296	Pre-Eclampsia	3p inactivates the Wnt/beta-catenin and PI3K/AKT pathways to promote the progression of PE via targeting the CEMIP.
transcription factor target	34156640	hsa-mir-99b	Osteoporosis	Within osteoporosis bone tissues, miR-99b-5p was upregulated and FGFR3 was downregulated. In conclusion, we identify a deregulated miRNA/mRNA axis in osteoporosis and osteogenic differentiation, namely the miR-99b-5p/FGFR3 axis; through targeting FGFR3, miR-99b-5p inhibits osteoblast proliferation and activity, which might subsequently affect the bone formation in osteoporosis progression.
other	34156425	hsa-mir-211	Glaucoma, Open-Angle	5p are implicated in POAG for the first time.
other	34156425	hsa-mir-221	Glaucoma, Open-Angle	5p are implicated in POAG for the first time.
other	34156425	hsa-mir-486	Glaucoma, Open-Angle	5p are implicated in POAG for the first time.
other	34156425	hsa-mir-92a	Glaucoma, Open-Angle	5p are implicated in POAG for the first time.
other	34156425	hsa-mir-143	Glaucoma, Open-Angle	5p are implicated in POAG for the first time.
other	34155879	hsa-mir-29b	Colorectal Neoplasms	In conclusion, it is deduced that miR-29b-3p/TRAF5 signaling axis plays critical role in drug resistance in chemotherapy for colorectal cancer patients by regulating necroptosis.
lncRNA target	34155816	hsa-mir-98	Arthritis, Rheumatoid	5p mimic or inhibitor.
circulation_biomarker_diagnosis_ns	34155619	hsa-mir-181d	Diabetes, Gestational	MATERIAL AND METHODS: The serum samples were collected from patients with GDM and subjected to qRT-PCR to verify the potential altered the miR-181d expression.
exosome	34155579	hsa-mir-181a	Reperfusion Injury	I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR
exosome	34155579	hsa-mir-26a	Reperfusion Injury	I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR
exosome	34155579	hsa-mir-21	Reperfusion Injury	I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR
genetics_knock down_promote	34154607	hsa-mir-140	Arthritis, Rheumatoid	CONCLUSION: CircMAPK9 knockdown might inhibit cell proliferation, migration, invasion, inflammatory response, and facilitate apoptosis in RA-FLSs via regulating miR
lncRNA target	34153672	hsa-mir-149	Osteoarthritis	Circ_0008956 contributed to IL-1beta-induced growth arrest and ECM degradation in chondrocytes via miR5p/NAMPT axis, suggesting a new insight into the pathogenesis of OA and a promising therapeutic target for OA treatment.
exosome	34153644	hsa-mir-26b	Endometrial Neoplasms	Taken together, our study reveals that exosomal NEAT1 from CAFs contributes to EC progression via miR-26a/b-5p-mediated STAT3/YKL-40 pathway, which indicates the therapeutic potential of exosomal NEAT1 for treating EC.
exosome	34153644	hsa-mir-26a	Endometrial Neoplasms	Taken together, our study reveals that exosomal NEAT1 from CAFs contributes to EC progression via miR-26a/b-5p-mediated STAT3/YKL-40 pathway, which indicates the therapeutic potential of exosomal NEAT1 for treating EC.
genetics_overexpression_promote	34153339	hsa-mir-424	Glioblastoma	miR-424 overexpression significantly suppressed cell proliferation and migration rate in glioblastoma cells based on the MTT and scratch assays.
genetics_overexpression_promote	34153312	hsa-mir-23b	Alzheimer Disease	Taken together, we conclude that overexpression of miR-23b can interrupt the pathogenesis of AD.
lncRNA target	34153299	hsa-mir-136	Carcinoma, Hepatocellular	5p/ILF2 axis plays a significant regulatory role in HCC progression, which may partly explain the pathogenic mechanisms of HCC and may provide promising potential targets for the diagnosis, treatment, and prognosis of HCC.
genetics_overexpression_promote	34153159	hsa-mir-485	Glioma	5p overexpression significantly reduced the growth of glioma xenografts and prolonged survival time.
other	34153004	hsa-mir-1231	Thyroid Cancer, Papillary	Our consequence showed circKIF4A facilitated the malignant progress of papillary thyroid tumor by sponging miR-1231 and upregulating GPX4 expression.
lncRNA target	34152928	hsa-mir-326	Breast Neoplasms	Conclusion: CircHIPK3 sponges miR-326 to promote BCa growth and metastasis.
circulation_biomarker_diagnosis_up	34152844	hsa-mir-126	Diabetic Nephropathies	Diabetic nephropathy patients' plasma hsa-miR
circulation_biomarker_diagnosis_up	34152844	hsa-mir-200a	Diabetic Nephropathies	Diabetic nephropathy patients' plasma hsa-miR
circulation_biomarker_diagnosis_up	34152844	hsa-mir-2115	Diabetic Nephropathies	Diabetic nephropathy patients' plasma hsa-miR
other	34152551	hsa-mir-3	Nervous System Diseases	3p in the context of neurological diseases.
genetics_GWAS	34152066	hsa-mir-17	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Overall, LSD1 functions as a cancer stem cell supporter in OSCC by catalyzing demethylation of miR-17 and activating the downstream KPNA2/PI3K/AKT pathway, which contributes to understanding of the mechanisms associated with epigenetic regulation in OSCC.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-19b	Asthma	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-125b	Asthma	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-19b	Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-19b	Pulmonary Disease, Chronic Obstructive	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-125b	Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
circulation_biomarker_diagnosis_up	34151771	hsa-mir-320c	Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome	hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS.
circulation_biomarker_diagnosis_up	34151771	hsa-mir-320c	Pulmonary Disease, Chronic Obstructive	hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS.
circulation_biomarker_diagnosis_up	34151771	hsa-mir-320c	Asthma	hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS.
circulation_biomarker_diagnosis_ns	34151771	hsa-mir-125b	Pulmonary Disease, Chronic Obstructive	OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases.
genetics_knock down_suppress	34151707	hsa-mir-211	Spinal Cord Injuries	Taken together, the knockdown of NEAT1 remarkably alleviated the inflammation of SCI via miR5p/MAPK1 axis.
circRNA target	34151690	hsa-mir-146b	Drug-Related Side Effects and Adverse Reactions	CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation.
circRNA target	34151690	hsa-mir-146b	Inflammation	CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation. Conclusion: Our findings demonstrated the regulation of circTMOD3 in LPS-induced cell injury and inflammation at least partially via miR-146b-3p-independent modulation of CXCR1.
genetics_knock down_promote	34151668	hsa-mir-223	Inflammatory Bowel Diseases	Besides, inhibition of NF-kappaB signalling attenuated the pyroptosis-promoting effect of overexpressing miR-223.Our data suggested that miR-223 activated the NF-kappaB pathway via targeting SNIP1, thus promoting the process of cell pyroptosis, and ultimately participating in the pathogenesis of IBD.
lncRNA target	34151476	hsa-mir-524	Osteosarcoma	circITCH sponged miR-524 to up-regulate RASSF6, causing OS progression inhibition and DXR resistance reduction.
target gene	34150620	hsa-let-7a	Stomach Neoplasms	Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth.
genetics_knock down_suppress	34150336	hsa-mir-194	Glioma	Animal experiments suggested that circ_0030018 knockdown could reduce glioma tumor growth through regulating miR
lncRNA target	34150180	hsa-mir-744	Glioma	Functional experiments showed that the inhibition of LINC01116 could up-regulate miR
circulation_biomarker_diagnosis_ns	34150128	hsa-mir-192	Multiple Myeloma	OBJECTIVE: To investigate the expression level of serum miRNA5p and its clinical value in the diagnosis and care of patients with multiple myeloma (MM).
other	34150094	hsa-mir-93	Carcinoma, Non-Small-Cell Lung	5p and miR-18a is associated with NSCLC severity and prognosis, and both can be used as potential markers for diagnosis.
other	34150094	hsa-mir-18a	Carcinoma, Non-Small-Cell Lung	5p and miR-18a is associated with NSCLC severity and prognosis, and both can be used as potential markers for diagnosis.
target gene	34150070	hsa-mir-1307	Osteosarcoma	DEX can effectively inhibit the proliferation, invasion, metastasis, and apoptosis of osteosarcoma cells in a dose-dependent manner, and its efficacy may be related to its regulation of miR-1307 expression.
other	34150061	hsa-mir-223	Coronary Disease	3p and NRF2 can be predictors of clinical efficacy.
transcription factor target	34150047	hsa-mir-335	Pre-Eclampsia	OBJECTIVE: To investigate the role of miRNA-335 on the proliferation and apoptosis of placental trophoblast cells in preeclamptic rats and its potential mechanism. CONCLUSION: miRNA-335 inhibition can enhance the expression of CRIM1 to promote the proliferation and reduce the apoptosis of trophoblast cells in preeclamptic rats.
other	34150044	hsa-mir-223	Alzheimer Disease	METHODS: SH-SY5Y cells were treated with Abeta 25-35 to simulate nerve injury in the pathogenesis of Alzheimer's disease (AD), and JAT-treated SH-SY5Y cells were assessed for HDAC4 and miR3p.
exosome	34150009	hsa-mir-153	Osteosarcoma	CONCLUSION: Highly enriched exosomal lncRNA OIP5-AS1 can regulate OS tumor angiogenesis and autophagy through miR-153 and ATG5.
exosome	34150007	hsa-mir-18a	Hirschsprung-Associated Enterocolitis	Collectively, exosomal miR-18a-5p was a promoter of HAEC, which induces the intestine cell apoptosis and inflammatory responses through the inhibition of SIRT1/NFkappaB pathway by targeting RORA.
exosome	34150007	hsa-mir-18a	Inflammatory Bowel Diseases	Collectively, exosomal miR-18a-5p was a promoter of HAEC, which induces the intestine cell apoptosis and inflammatory responses through the inhibition of SIRT1/NFkappaB pathway by targeting RORA.
target gene	34150003	hsa-mir-142	Breast Neoplasms	Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway.
genetics_knock down_promote	34149934	hsa-mir-455	Cholangiocarcinoma	In support, overexpression of miR
circulation_biomarker_diagnosis_up	34149922	hsa-mir-223	Carcinoma, Hepatocellular	3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR
circulation_biomarker_diagnosis_up	34149922	hsa-mir-423	Carcinoma, Hepatocellular	3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR
circulation_biomarker_diagnosis_up	34149922	hsa-mir-365a	Carcinoma, Hepatocellular	3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR
circulation_biomarker_diagnosis_up	34149922	hsa-mir-26a	Carcinoma, Hepatocellular	3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR
target gene	34149919	hsa-mir-615	Uterine Cervical Neoplasms	Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis.
other	34149906	hsa-mir-27a	Stomach Neoplasms	5p, may serve critical roles in EGC.
other	34149906	hsa-let-7a	Stomach Neoplasms	5p, may serve critical roles in EGC.
other	34149906	hsa-mir-126	Stomach Neoplasms	5p, may serve critical roles in EGC.
other	34149906	hsa-mir-424	Stomach Neoplasms	5p, may serve critical roles in EGC.
other	34149904	hsa-mir-182	Breast Neoplasms	The results revealed that the expression levels of miR5p, PD-L1 and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) were upregulated in MDA-MB-231 cells and BC tissues.
transcription factor target	34149902	hsa-mir-4491	Carcinoma, Non-Small-Cell Lung	In addition, TRIM7 silencing attenuated the effect of miR-4491 inhibitor in NSCLC cells.
other	34149892	hsa-mir-20a	Lung Neoplasms	Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR-20a expression.
other	34149890	hsa-mir-200a	Ischemic Stroke	Collectively, the present results suggested that LINC00319 promoted apoptosis and aggravated neuronal injury induced by OGD by regulating miR-200a-3p, which may be important for ischemic stroke treatment.
lncRNA target	34149889	hsa-mir-24	Burns	5p and targeting CDK16 in the HDFs after thermal injury, implying a protective role for TPT1-AS1 in the burn wound healing process.
other	34149884	hsa-mir-125b	Acquired Immunodeficiency Syndrome	The expression of miR-125b-5p and ASCT2 mRNA was detected in colon biopsy samples of 10 patients with AIDS and 10 control healthy subjects. The results demonstrated that miR-125b-5p levels were increased and ASCT2 mRNA expression levels were decreased in colon samples from patients with AIDS and in LPS-induced intestinal mucosa cells.
circulation_biomarker_diagnosis_ns	34149877	hsa-mir-200b	Angelman Syndrome	Furthermore, miR-200b-3p expression was negatively correlated with ABCA1 expression in the blood of the patients with As.
other	34149871	hsa-mir-155	Diabetic Neuropathies	The present study demonstrated the involvement of the miR-155/COX-2 axis in the protective effect of CXB against high glucose-induced DN.
transcription factor target	34149870	hsa-mir-133a	Gastrointestinal Diseases	These results suggested that miR-133a-3p may be a promising therapeutic target for the diagnosis and treatment of gut-origin sepsis.
transcription factor target	34149870	hsa-mir-133a	Sepsis	These results suggested that miR-133a-3p may be a promising therapeutic target for the diagnosis and treatment of gut-origin sepsis.
other	34149807	hsa-mir-126	Adenocarcinoma of Lung	5p/TEK as immune-related ceRNA networks in LUAD progression.
other	34149807	hsa-mir-21	Adenocarcinoma of Lung	5p/TEK as immune-related ceRNA networks in LUAD progression.
transcription factor target	34149802	hsa-mir-196a	Parkinson Disease	The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology.
transcription factor target	34149802	hsa-mir-499a	Parkinson Disease	The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology.
transcription factor target	34149802	hsa-mir-29a	Parkinson Disease	The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology.
genetics_overexpression_suppress	34149728	hsa-mir-145	Sjogren's Syndrome	5p modulates MUC1 and TLR4 overexpression in SG from SS-patients in a type I IFN dependent manner.
lncRNA target	34149433	hsa-mir-10a	Osteoarthritis, Knee	The results showed that miR-10a-3p can recover the OA features through targeting CH25H/CYP7B1/RORalpha axis.
lncRNA target	34149433	hsa-mir-10a	Cartilage Diseases	The results showed that miR-10a-3p can recover the OA features through targeting CH25H/CYP7B1/RORalpha axis.
other	34149424	hsa-mir-199a	Death, Sudden	Furthermore, although this investigation was not designed to characterize the safety of transplanted AAV6-miR-199a-transduced hiPSC-CMs, there was no evidence of sudden death.
other	34149424	hsa-mir-199a	Heart Diseases	microRNAs are key regulators of cardiomyocyte proliferation, and when adeno-associated viruses coding for microRNA-199a (miR-199a) expression were injected directly into infarcted pig hearts, measures of cardiac function and fibrosis significantly improved, but the treatment was also associated with lethal arrhythmia.
lncRNA target	34149180	hsa-mir-183	Thyroid Cancer, Papillary	5p directly targeted PPP2R2A, and promoted PTC progression through regulating PPP2R2A.
other	34149178	hsa-mir-582	Glioma	LncRNA-NNT-AS1 contributes to the progression of glioma by miR-582-5p/EZH2 axis.
lncRNA target	34149174	hsa-mir-379	Stomach Neoplasms	5p, indicating that LINC00665 might be a potential therapeutic target for DDP- resistant GC patients.
target gene	34149172	hsa-mir-4735	Ovarian Neoplasms	LncRNA ARAP1-AS1 aggravates the malignant phenotypes of ovarian cancer cells through sponging miR-4735-3p to enhance PLAGL2 expression.
lncRNA target	34148561	hsa-mir-206	Polycystic Ovary Syndrome	CONCLUSIONS: Highly expressed lncROR indirectly up-regulated the expression of VEGF by down-regulating the expression of miR-206, thereby promoting the proliferation of KGN cells and inhibiting apoptosis, and further promoting the development of PCOS.
other	34148372	hsa-mir-501	Breast Neoplasms	LncRNA-miRNA-mRNA network highlighted a potential mechanism of BCBM in which lncRNA FIRRE and RP11-169F17.1 sponging hsa-miR5p to regulate the expression of MMS19, PTBP1 and NUP98.
genetics_overexpression_promote	34148288	hsa-mir-375	Carcinoma, Hepatocellular	The transfection of circ_0072088 overexpression plasmid or miR-375 inhibitors promoted the proliferation, migration, and invasion, and inhibited the apoptosis of HCC cells, whereas transfection of circ_0072088 siRNA or miR-375 mimics exerted opposite effects.
other	34148185	hsa-mir-421	Carcinoma, Hepatocellular	Our data suggest that Tregs, CD4 T cells, mast cells, SNHG1, HMMR and hsa-miR-421 are associated with HCC based on ceRNA immune cells co-expression patterns.
lncRNA target	34148029	hsa-mir-29b	Carcinoma, Hepatocellular	Moreover, miR-29b-3p has been identified as a negatively regulatory target gene of HCP5, and served as a tumor suppressor of HCC to prevent cell proliferation, migration, and invasion.
lncRNA target	34147937	hsa-mir-508	Precursor Cell Lymphoblastic Leukemia-Lymphoma	5p were nominated from a list of putative miRNAs targeting ABCA3.
genetics_knock down_promote	34147851	hsa-mir-934	Breast Neoplasms	However, miR-934 knockdown significantly inhibited the migration and invasion abilities of BC cells.
circRNA target	34147657	hsa-mir-556	Angelman Syndrome	Thus, we came a conclusion that circDIP2C protected against ox-LDL-induced HUVEC damage by upregulating TET2 expression through sponging miR5p, which provided a strategy for the therapy of AS.
lncRNA target	34147470	hsa-mir-433	Glioma	3p inhibits the malignant progression of glioma by targeting and down-regulating the expression of SMC4.
exosome	34147083	hsa-mir-203a	Colorectal Neoplasms	COCLUSION: MiR-203a-3p derived from hepatocyte exosomes plays an important role of CRC cells to colonize in liver.
transcription factor target	34147072	hsa-mir-206	Osteoarthritis	CONCLUSION: MiR-206 contributed to the progression of OA by modulating Th17/Treg imbalance, suggesting that miR-206 inhibition might be a promising therapeutic strategy for the treatment of OA.
genetics_overexpression_promote	34146927	hsa-mir-146a	Periodontitis	Overexpression of microRNA-146a inhibited proliferation of PDLSCs derived from both periodontitis-affected teeth and healthy teeth while downregulating IL-13.
lncRNA target	34146302	hsa-mir-124	Myocardial Infarction, Acute	3p expression may activate the FGF21/CREB/PGC1alpha pathway to reduce cell apoptosis, alleviate the inflammatory response, and attenuate oxidative stress in AMI rats by targeting SIRT1.
virus_miRNA	34146250	ebv-mir-BART11	stomach carcinoma	Eukaryotic initiating factor eIF4E is targeted by EBV-encoded miR-BART11-3p and regulates cell cycle and apoptosis in EBV-associated gastric carcinoma
other	34146198	hsa-mir-3	Diabetes Mellitus	These findings support the possible role of miR-33 to monitor pre-diabetes onset and progression.
exosome	34146092	hsa-mir-21	Keloid	Here, we extracted exosomes from the culture supernatants of keloid and normal skin fibroblasts and observed that both types of cells above secrete exosomes; however, keloid fibroblasts secreted significantly more exosomal miR-21 than normal skin fibroblasts (P < .001).
genetics_overexpression_suppress	34145797	hsa-mir-199b	Endometrial Neoplasms	MiR-199b-5p inhibitors or SLC7A5 overexpression attenuated circZNF124 silencing-mediated EC malignant progression.
other	34145485	hsa-mir-142	Norrie disease	The finding might provide novel insight into the role of miR3p/BOD1 axis in DN treatment.
genetics_overexpression_promote	34145425	hsa-mir-181c	Ovarian Neoplasms	Overexpression of miR-181c sensitized resistant OC to PTX by inhibiting the PI3K/Akt pathway in vitro and in vivo.
lncRNA target	34145399	hsa-mir-17	Colorectal Neoplasms	In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.
circulation_biomarker_diagnosis_ns	34144376	hsa-mir-346	Tuberculosis	The mean serum log hsa-miR-346 levels were -15.48 (-15.76 to -15.21) in patients with tuberculosis and -16.12 (-16.29 to -15.95) in healthy volunteers, which significantly differed.
lncRNA target	34144190	hsa-mir-139	Myocardial Infarction, Acute	5p inhibits endothelial cell viability of AMI by inhibiting VEGFR-1, and increased miR
transcription factor target	34143694	hsa-mir-145	Hyperlipidemias	In conclusion, MiR5p modulated lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating beta-catenin signaling in hyperlipidemia, which may provide a potential biomarker for the treatment of hyperlipidemia-induced cardiovascular diseases.
epigenetics	34143366	hsa-mir-181a	Thyroid Cancer, Papillary	KDM5C was identified as the target gene of miR-181a and represses S100A2 expression through histone demethylation to diminish the migration and proliferation of PTC cells.
lncRNA target	34143347	hsa-mir-135a	Asthma	In conclusion, SB inhibited NLRP3 inflammasome activation and reduced pyroptosis via the miR-135a-5p/TRPC1/STAT3/NF-kappaB axis, thus alleviating airway inflammation and airway remodeling in asthma.
lncRNA target	34143347	hsa-mir-135a	Pneumonia	In conclusion, SB inhibited NLRP3 inflammasome activation and reduced pyroptosis via the miR-135a-5p/TRPC1/STAT3/NF-kappaB axis, thus alleviating airway inflammation and airway remodeling in asthma.
circRNA target	34143288	hsa-mir-127	Carcinoma, Squamous Cell, Cutaneous	Hsa_circ_0008234 facilitates the proliferation of cSCC through targeting miR
other	34142698	hsa-mir-139	Diabetes Mellitus	High fatty acid reduces insulin secretion in pancreatic beta-cells and miR5p is increased in diabetic pancreatic tissues and induces islet beta-cell apoptosis.
lncRNA target	34142340	hsa-mir-448	Prostatic Neoplasms	CONCLUSIONS: Our research shows that circHIPK3 plays a carcinogenic effect in PCa by regulating the miR-448/MTDH axis, indicating that circHIPK3 may be a potential therapeutic target for PCa.
circulation_biomarker_prognosis_ns	34141710	hsa-mir-2276	Glioma	5p is significantly reduced in the plasma of glioma patients, and thus, it could be a potential biomarker for patients with glioma for diagnostic and/or prognostic purposes.
other	34141614	hsa-mir-204	Thyroid Neoplasms	In summary, our study found a potential mechanism in which hsa-miR5p regulated ALPL in activated dendritic cells, which may allow them to play a critical role in thyroid carcinoma.
other	34141611	hsa-mir-16-1	Osteosarcoma	Silencing of the Long Non-Coding RNA TTN-AS1 Attenuates the Malignant Progression of Osteosarcoma Cells by Regulating the miR-16-1-3p/TFAP4 Axis.
lncRNA target	34141179	hsa-mir-26a	Aortic Aneurysm, Abdominal	In short, CurTn suppressed VSMCs pyroptosis and inflammation though mediation PVT1/miR-26a/KLF4 axis by regulating the PI3K/AKT signaling pathway, CurTn might consider as a potential therapeutic target in the treatment of AAA.
lncRNA target	34141159	hsa-mir-146a	Drug-Induced Kidney Injury	This nephrotoxicity mediated by upregulation of the messenger RNA (mRNA) gene expression of the autophagy markers: Beclin-1, microtubule-associated protein LC3, p62 binding protein, immunoglobulin G receptor Fcgamma receptor (FcgammaR), micro-RNA-1 (miR-1), protein expression of phospho-adenosine monophosphate-activated protein kinase, and phospho-mammalian target of rapamycin, along with downregulation of miR-146a mRNA gene expression and alteration of calcium and iron levels.
lncRNA target	34141159	hsa-mir-1	Drug-Induced Kidney Injury	This nephrotoxicity mediated by upregulation of the messenger RNA (mRNA) gene expression of the autophagy markers: Beclin-1, microtubule-associated protein LC3, p62 binding protein, immunoglobulin G receptor Fcgamma receptor (FcgammaR), micro-RNA-1 (miR-1), protein expression of phospho-adenosine monophosphate-activated protein kinase, and phospho-mammalian target of rapamycin, along with downregulation of miR-146a mRNA gene expression and alteration of calcium and iron levels.
genetics_GWAS	34141156	hsa-mir-124	Neural Tube Defects	MiR-124 down-regulation may occur via epigenetic mechanisms and contribute to HCY-induced NTDs in chick embryo models.
genetics_knock down_suppress	34140798	hsa-mir-31	Inflammatory Bowel Diseases	CONCLUSION: Our data determined that UCA1 knockdown attenuated UC development via targeting the miR
other	34140779	hsa-mir-210	Lung Neoplasms	miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3.
circulation_biomarker_diagnosis_up	34140641	hsa-mir-135b	Colorectal Neoplasms	And miR-135b-5p was increased in the serum of colorectal cancer patients.
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-1287	Diabetes Mellitus	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-197	Diabetic Nephropathies	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-1287	Diabetic Nephropathies	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-197	Diabetes Mellitus	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-28	Diabetes Mellitus	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
circulation_biomarker_diagnosis_ns	34140396	hsa-mir-28	Diabetic Nephropathies	RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR
genetics_overexpression_promote	34140036	hsa-mir-337	Osteoarthritis	3p overexpression-mediated facilitation in viability, and inhibition in apoptosis, TNF-alpha and IL-6 generation and ECM degradation in OA model cells.
genetics_knock down_promote	34140005	hsa-mir-149	Esophageal Squamous Cell Carcinoma	The overexpression of MEG3, p53 or miR
transcription factor target	34139980	hsa-mir-1	Adenocarcinoma of Lung	3p could suppress the malignant phenotypes of LUAD cells by targeting CELSR3, which will help to provide novel therapeutic strategies for LUAD sufferers and new references for the targeted therapy of LUAD.
lncRNA target	34139933	hsa-mir-378b	Carcinoma, Hepatocellular	Circ_0078710 interference-induced effects in curcumin-stimulated HCC cells were partly abolished by the silence of miR-378b. CONCLUSIONS: Circ_0078710 silencing aggravated curcumin-mediated anti-tumor effects through mediating the miR-378b/PRIM2 signaling in HCC cells.
genetics_overexpression_promote	34139744	hsa-mir-532	Myocardial Infarction	ACAP2 is overexpressed in MI and may promote the maturation of miR-532 to induce the apoptosis of cardiomyocyte.
genetics_knock down_suppress	34139630	hsa-mir-193	Endometritis	In conclusion, our study firstly reported the mechanism by which miR-193a-3p targets LGR4 to elevate the inflammatory response in bovine endometrium injury, thereby implying that knockdown miR-193a-3p may lay the theoretical and practical basis for drug development of alleviating endometritis in dairy cows.
genetics_knock down_suppress	34139630	hsa-mir-193a	Endometritis	In conclusion, our study firstly reported the mechanism by which miR-193a-3p targets LGR4 to elevate the inflammatory response in bovine endometrium injury, thereby implying that knockdown miR-193a-3p may lay the theoretical and practical basis for drug development of alleviating endometritis in dairy cows.
transcription factor target	34139323	hsa-mir-467b	Non-alcoholic Fatty Liver Disease	This suggests that targeting of the HNF4alpha/miR-467b-3p/GPAT1 cascade may be used as a potential therapeutic strategy to control NAFLD.
transcription factor target	34139319	hsa-mir-125a	Liver Injury	Dysregulation of miR-125a-5p might be a possible mechanism of isoflurane-induced liver injury.
lncRNA target	34138419	hsa-mir-93	Kidney Failure, Chronic	CONCLUSION: MiR-93, via inhibiting the activity of Wnt/beta-catenin pathway by targeting TCF4, can improve the renal function of CRF rats, thereby mitigating the vascular calcification of CRF.
genetics_knock down_promote	34138410	hsa-mir-100	Cardiomegaly	Knockdown of miR
genetics_overexpression_suppress	34137496	hsa-mir-126	Scleroderma, Systemic	Inhibition of miR-126 in NL-MVECs resulted in reduced angiogenic capacity, whereas overexpression of miR-126 in SSc-MVECs resulted in enhanced tube assembly.
other	34137440	hsa-mir-210	Hypoxia	Furthermore, we found that coilin is needed for the hypoxic induction of a well-known hypoxia-induced miRNA (hypoxamiR), miR-210, as well as for the hypoxia-induced alternative splicing of the miR-210 host gene, MIR210HG.
other	34137197	hsa-mir-624	Duane Retraction Syndrome	3p in human retinal endothelial cells.
circRNA target	34136582	hsa-mir-296	Uterine Cervical Neoplasms	5p/HMGA1 pathway may be a potential target for the treatment of cervical cancer.
other	34136547	hsa-mir-155	Death, Sudden, Cardiac	miR-155 is one of the best characterized miRNAs and plays a critical role in several physiological and pathological process, including cardiovascular diseases.
genetics_overexpression_promote	34136482	hsa-mir-92b	Small Cell Lung Carcinoma	Importantly, exosomes isolated from the conditioned medium of SBC-3 cells overexpressing miR-92b-3p could promote SCLC chemoresistance and cell migration.
circRNA target	34136401	hsa-mir-141	Adenocarcinoma of Lung	Our findings suggest that circKEAP1 inhibits LUAD progression through circKEAP1/miR
target gene	34135963	hsa-mir-455	Carcinoma, Hepatocellular	miR-455 Inhibits the Viability and Invasion by Targeting RAB18 in Hepatocellular Carcinoma.
other	34135940	hsa-mir-148a	Colorectal Neoplasms	Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer.
other	34135841	hsa-mir-6810	Macular Degeneration	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-196a	Macular Degeneration	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-6499	Macular Degeneration	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-7854	Macular Degeneration	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-6499	Neurodegenerative Diseases	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-6796	Macular Degeneration	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-7854	Neurodegenerative Diseases	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-6810	Neurodegenerative Diseases	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-196a	Neurodegenerative Diseases	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135841	hsa-mir-6796	Neurodegenerative Diseases	In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes.
other	34135769	hsa-mir-223	Vasculitis	In conclusion, septic platelets released PMPs carrying functional miR-223 lower ICAM1 expression in endothelial cells, which may be a protective role against excessive sepsis-induced vascular inflammation.
other	34135670	hsa-mir-191	Triple Negative Breast Neoplasms	This study demonstrates that miR-191 liposomes may have promising clinical applications for TNBC therapy.
genetics_overexpression_suppress	34135635	hsa-mir-613	Esophageal Squamous Cell Carcinoma	In ESCC cells, CircRIMS overexpression decreased the expression of miR-613 and increased the methylation of miR-613 gene.
other	34135620	hsa-mir-28	Reperfusion Injury, Cerebral Ischemia	3p aggravated cerebral I/R injury.
other	34135620	hsa-mir-28	Stroke	3p aggravated cerebral I/R injury.
lncRNA target	34135616	hsa-mir-148b	Myocardial Infarction	CONCLUSION: This study demonstrated for the first time the important mechanism of action of the NEAT1/miR-148b-3p/ICAM-1 axis in the progression of CSF disease, and indicated the potential of NEAT1, miR-148b-3p, and ICAM-1 as a new target for the diagnosis and treatment of CSF.
target gene	34135597	hsa-mir-326	Breast Neoplasms	circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326.
other	34135596	hsa-mir-942	Adenocarcinoma of Lung	5p), and the DEGs (IGF2BP3, MKI67, CD79A, and ABAT) may serve as prognostic markers in LUAD.
other	34135596	hsa-mir-532	Adenocarcinoma of Lung	5p), and the DEGs (IGF2BP3, MKI67, CD79A, and ABAT) may serve as prognostic markers in LUAD.
genetics_overexpression_promote	34135394	hsa-mir-520g	Carcinoma, Hepatocellular	Furthermore, overexpression of p53-R175H and p53-R273H mutants promote miR-520G and MAGEA RNA expression and cellular transformation.
circulation_biomarker_diagnosis_ns	34134962	hsa-mir-16	Ovarian Neoplasms	The miR-16/polypeptide nanoparticles could be efficiently absorbed by human ovarian cancer cells and were distributed in the cytoplasm.
other	34134782	hsa-mir-152	Breast Neoplasms	3p could be considered a promising regulator of BC chemoresistance.
genetics_overexpression_promote	34134765	hsa-mir-20a	Osteoporosis	In this study, we intended to determine whether sEVs overexpressing miR-20a could exert a superior effect on osteoporotic bone defects and the underlying mechanism.
circulation_biomarker_diagnosis_up	34134589	hsa-mir-574	Sepsis	Thus, serum miR
circulation_biomarker_diagnosis_up	34134589	hsa-mir-574	Acute Kidney Injury	Thus, serum miR
other	34134471	hsa-mir-99a	Leukemia, Myeloid, Acute	Interestingly, upregulation of MIR99AHG and deregulation of the miRNA cluster, residing in the MIR99AHG locus, are known mechanisms of leukemogenesis in acute megakaryoblastic leukemia.
circulation_biomarker_diagnosis_up	34134454	hsa-mir-125a	Arthritis, Rheumatoid	3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients.
circulation_biomarker_diagnosis_up	34134454	hsa-mir-24	Arthritis, Rheumatoid	3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients.
circulation_biomarker_diagnosis_up	34134454	hsa-mir-146a	Arthritis, Rheumatoid	3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients.
other	34134453	hsa-mir-25	Multiple Sclerosis	Our results indicate that miR3p expression is likely induced by inflammatory mediators during autoimmune neuroinflammation.
genetics_GWAS	34134452	hsa-mir-124	Arthritis, Rheumatoid	Our findings propose a considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population.
genetics_GWAS	34134452	hsa-mir-124	Lupus Erythematosus, Systemic	Our findings propose a considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population.
lncRNA target	34133012	hsa-mir-145	Spinal Cord Injuries	5p inhibition mitigates inflammation and oxidative stress via targeting Nurr1 to regulate TNF-alpha signaling, which ameliorates SCI.
genetics_overexpression_suppress	34133001	hsa-mir-377	Osteosarcoma	3p overexpression in vivo.
genetics_knock down_suppress	34132956	hsa-mir-122	Ovarian Neoplasms	5p overexpression inhibited the progression of OC cells by targeting SLC1A5.
circulation_biomarker_diagnosis_ns	34132944	hsa-mir-25	Colorectal Neoplasms	Herein, we aim to evaluate the diagnostic potentials of plasma microRNA-211 and microRNA-25 in colorectal cancer patients. MicroRNA-211 and microRNA-25 might have a tumorigenic role in colorectal cancer and their plasma levels could be potential biomarkers in its diagnosis.
genetics_overexpression_promote	34132932	hsa-mir-129	Glioblastoma	5p overexpression inhibited GBM cell chemoresistance to TMZ and proliferation, and promoted cell apoptosis.
lncRNA target	34132637	hsa-mir-21	Gynatresia	5 p to inhibit miR
circulation_biomarker_diagnosis_down	34132380	hsa-mir-193a	Carcinoma, Ovarian Epithelial	The results indicated that the expression levels of miR193a5p were significantly decreased in serum samples obtained from patients with EOC and EOC cell lines compared with healthy individuals and normal cells, respectively.
genetics_overexpression_suppress	34132375	hsa-mir-431	Carcinoma, Ovarian Epithelial	Mechanistically, LINC01132 acted as a competing endogenous RNA by sequestering miR4315p and consequently overexpressing SOX9 in EOC cells, forming a LINC01132/miR4315p/SOX9 axis.
genetics_knock down_suppress	34132371	hsa-mir-429	Squamous Cell Carcinoma of Head and Neck	The present study examined the biological function of miR429 by performing the gain/lossoffunction studies of miR429 in a gingival squamous cell carcinoma line Ca922 cells that either over or underexpressed miR429 through transient transfection with miR429 mimic or miR429 inhibitor, respectively.
lncRNA target	34132371	hsa-mir-429	Mouth Diseases	Taken together, the findings revealed the molecular mechanism of miR429 to regulate the inflammatory mediator in gingival cells and suggested that it could be useful as a therapeutic target of oral inflammatory diseases.
other	34132362	hsa-mir-375	Liver Neoplasms	Furthermore, it was identified that increased mRNA stability was the primary reason for the upregulation of YAP expression in LC/CDDP cells, which was due to the downregulation of microRNA (miR)375 expression in LC/CDDP cells. In conclusion, the findings of the present study suggested that the miR375/YAP axis may regulate the expression levels of IL6 and TGFbeta, which may subsequently be involved in the CDDP resistance of LC cells.
genetics_knock down_promote	34132358	hsa-mir-16	Urinary Bladder Neoplasms	Furthermore, it was found that blockade of the BIMP1/NFkappaB signaling pathway inversed the inhibitory effects of miR165p knockdown on autophagy in BC cells.
genetics_knock down_promote	34132358	hsa-mir-16	bladder urothelial carcinoma	Furthermore, it was found that blockade of the BIMP1/NFkappaB signaling pathway inversed the inhibitory effects of miR165p knockdown on autophagy in BC cells.
circulation_biomarker_diagnosis_up	34132029	hsa-mir-199a	Aortic Aneurysm, Abdominal	The level of miR-199a-5p expression was upregulated in the plasma from AAA patients and Ang II-treated VSMCs.
genetics_overexpression_promote	34131397	hsa-mir-135b	Stomach Neoplasms	The in vitro functional assays demonstrated overexpression of miR-135b promoted cell proliferation, migration and invasion in GC, while miR-135b inhibition led to the opposite results.
other	34131232	hsa-mir-135b	Incontinentia Pigmenti	Among them, miR5p and miR-135b-5p were significantly downregulated by IPC.
other	34131232	hsa-mir-3	Incontinentia Pigmenti	Among them, miR5p and miR-135b-5p were significantly downregulated by IPC.
other	34131111	hsa-mir-326	Adenocarcinoma of Lung	Collectively, miR-326 restrained tumor progression by downregulating PD-L1 and B7-H3 expression and increasing T cell cytotoxic function in LUAD.
other	34131106	hsa-mir-21	Myocardial Reperfusion Injury	Furthermore, we identified MARCH5 as a modifier of miR5p, and its effect on mitochondrial fission and fusion are directly proportional to PVT1 expression during H/R injury.
genetics_knock down_promote	34131104	hsa-mir-155	Carcinoma, Renal Cell	Gain and loss-of-function studies further investigated the effect of transferred hypoxic exosomal miR
lncRNA target	34131102	hsa-mir-98	Thyroid Cancer, Papillary	METHODS: Expression of lncRNA OIP5-AS1 and miR-98 in PTC tissue and cells were measured by quantitative real-time PCR (qRT-PCR). OIP5-AS1 promotes PTC cell progression through miR-98/ADAMTS8 and EGFR, MEK/ERK pathways.
genetics_overexpression_promote	34131101	hsa-mir-103a	Carcinoma, Hepatocellular	In addition, high miR-103a expression was associated with poor patient prognosis, and its overexpression promoted HCC cell growth and mobility.
other	34130645	hsa-mir-770	Squamous Cell Carcinoma of Head and Neck	Furthermore, we validated that LINc02086/miR5p/SLC26A2 axis promoted migration in LSCC.
lncRNA target	34130607	hsa-let-7	Multiple Sclerosis	T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group.
circulation_biomarker_diagnosis_up	34130607	hsa-mir-26	Multiple Sclerosis	T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS.
circulation_biomarker_diagnosis_up	34130607	hsa-mir-20	Multiple Sclerosis	T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS.
lncRNA target	34130607	hsa-mir-21	Multiple Sclerosis	T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group.
circulation_biomarker_diagnosis_up	34130607	hsa-mir-155	Multiple Sclerosis	T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS.
lncRNA target	34130587	hsa-mir-17	Thyroid Neoplasms	5p inhibition repressed cell proliferation, clonal formation, cell migration, and cell invasion in thyroid carcinoma.
genetics_overexpression_promote	34130584	hsa-mir-188	Breast Neoplasms	3p, overexpression of TMED3 or blocking Wnt/beta-catenin signalling all attenuated the roles of RP11-283G6.5 in breast cancer.
genetics_overexpression_promote	34130294	hsa-mir-221	Adenocarcinoma, Follicular	What's more, overexpression of GAS5 or miR
lncRNA target	34129971	hsa-mir-200a	Glioma	RESULTS: Expression of circNCAPG and RAB5A was upregulated, and miR-200a-3p was decreased in glioma tissues and cells, while their expression presented an opposite trend in Pro-treated glioma cells. CONCLUSIONS: Pro could inhibit glioma cell growth and metastasis through the circNCAPG/miR-200a-3p/RAB5A axis, providing a promising therapeutic strategy for glioma treatment.
exosome	34129838	hsa-mir-424	Colorectal Neoplasms	CONCLUSION: Inhibited exosomal miR-424 from BMSCs inhibited malignant behaviors of CRC cells by targeting TGFBR3, thus suppressing the progression of CRC.
circulation_biomarker_diagnosis_up	34129195	hsa-mir-9	Retinoblastoma	RESULTS: Initially, the expression level of miR-9 was significantly decreased in the RB tissues and blood samples from patients with RB.
other	34128858	hsa-mir-3199	Thymic epithelial tumor	After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199).
other	34128858	hsa-mir-143	Thymic epithelial tumor	After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199).
other	34128858	hsa-mir-141	Thymic epithelial tumor	After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199).
other	34128858	hsa-mir-140	Thymic epithelial tumor	After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199).
genetics_GWAS	34128842	hsa-mir-4766	Essential Hypertension	5p.The PTX3 rs2614 locus SNP is significantly associated with EHT risk.
lncRNA target	34128362	hsa-mir-93	Triple Negative Breast Neoplasms	CONCLUSION: HAGLR could promote the progression of TNBC through the miR
circulation_biomarker_prognosis_ns	34127929	hsa-mir-614	Colorectal Neoplasms	5p expression of colorectal cancer was significantly correlated with N stage (OR) = 0.7 for N1&N2 vs. N0), M stage (OR = 0.5 for M1 vs. M0), pathologic stage (OR = 0.7 for Stage III & Stage IV vs. Stage I & Stage II), neoplasm type (OR = 0.5 for rectum adenocarcinoma vs. colon adenocarcinoma), and lymphatic invasion (OR = 0.6 for YES vs. NO) (all p-values < 0.05).
lncRNA target	34127806	hsa-mir-4736	Prostatic Neoplasms	3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs.
lncRNA target	34127806	hsa-mir-125b-2	Urinary Bladder Neoplasms	3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs.
lncRNA target	34127806	hsa-mir-4736	Urinary Bladder Neoplasms	3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs.
lncRNA target	34127806	hsa-mir-125b-2	Prostatic Neoplasms	3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs.
genetics_knock down_promote	34127015	hsa-mir-1205	Colorectal Neoplasms	CircASXL1 knockdown inhibited cell colony-forming ability, migration and invasion, whereas induced cell arrest at G0/G1 phase and cell apoptosis in CRC cells; however, these effects were attenuated by miR-1205 inhibitor.
lncRNA target	34127010	hsa-mir-194	Carcinoma, Non-Small-Cell Lung	5p enhanced the sensitivity of NSCLC cells to DOX by directly inhibiting HIF-1.
lncRNA target	34126989	hsa-mir-135b	Triple Negative Breast Neoplasms	The bioinformatics prediction revealed that circ_0044234 could act as an upstream sponge in the miR-135b/GATA3 axis, two of the most dysregulated transcripts in TNBC. Our comprehensive approach revealed the potential circ_0044234/miR135b-5p/GATA3 ceRNA axis in TNBC.
lncRNA target	34126893	hsa-mir-15b	Prostatic Neoplasms	Mechanistically, AFAP1-AS1 functioned as an oncogene in PCa through binding to miR-15b and destroying its tumor suppressor function. CONCLUSION: AFAP1-AS1 facilitates PCa progression by regulating miR-15b/IGF1R axis, indicating that AFAP1-AS1 may serve as a diagnostic biomarker and therapeutic target for PCa.
genetics_overexpression_promote	34126886	hsa-mir-92a	Carcinoma, Hepatocellular	MTT, flow cytometry, wound healing, Transwell invasion assays and western blot were conducted to uncover that overexpressed miR-92a-3p could boost the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of HCC cells while inhibiting cell apoptosis.
circulation_biomarker_diagnosis_ns	34126831	hsa-mir-135b	Diabetes, Gestational	5p and miR-3135b exhibited significantly lower expression in plasma samples from GDM patients.
circulation_biomarker_diagnosis_ns	34126831	hsa-mir-574	Diabetes, Gestational	5p and miR-3135b exhibited significantly lower expression in plasma samples from GDM patients.
lncRNA target	34126594	hsa-mir-27b	Breast Neoplasms	MiR-27b-3p targeted YAP in the breast cancer cells.
genetics_overexpression_promote	34126237	hsa-mir-23a	Pulmonary Arterial Hypertension	On the contrary, PAHRF-overexpressing plasmid inhibited the expression of miR-23a-3p in hypoxia.
lncRNA target	34125980	hsa-mir-181a	Pulmonary Disease, Chronic Obstructive	Mechanically, rescue assays demonstrated that miR-181a-5p inhibition could partially counteract the impact of LUCAT1 on COPD progression through the Wnt/beta-catenin pathway.
other	34125651	hsa-mir-144	Stomach Neoplasms	This study aimed to evaluate the expression changes of miR-144 and miR-375 in the human gastric adenocarcinoma cell line (AGS) under the exposure of ELF-EMF.
other	34125651	hsa-mir-375	Stomach Neoplasms	This study aimed to evaluate the expression changes of miR-144 and miR-375 in the human gastric adenocarcinoma cell line (AGS) under the exposure of ELF-EMF. Up-regulation of miR-144 and miR-375 were observed in AGS cells under the exposure of magnetic fields.
genetics_knock down_promote	34125645	hsa-mir-23a	Breast Neoplasms	MiR-323a-3p inhibition reversed the role of NORAD knockdown in the biological functions of BC cells while silencing PUM1 reversed the influence of NORAD overexpression on BC cells.
circulation_biomarker_prognosis_up	34125460	hsa-mir-222	Colorectal Neoplasms	The results of our present study identified a gene cluster, miR-221/222, that is constitutively upregulated in serum exosome samples of patients with colorectal carcinoma (CRC) with liver metastasis (LM); this upregulation predicts a poor overall survival rate. Overall, our results show that exosomal miR-221/222 promotes CRC progression and may serve as a novel prognostic marker and therapeutic target for CRC with LM.
circulation_biomarker_prognosis_up	34125460	hsa-mir-221	Colorectal Neoplasms	The results of our present study identified a gene cluster, miR-221/222, that is constitutively upregulated in serum exosome samples of patients with colorectal carcinoma (CRC) with liver metastasis (LM); this upregulation predicts a poor overall survival rate. Overall, our results show that exosomal miR-221/222 promotes CRC progression and may serve as a novel prognostic marker and therapeutic target for CRC with LM.
lncRNA target	34125401	hsa-mir-1178	Carcinoma, Hepatocellular	3p functions as a tumor suppressor in HCC through regulating TBL1XR1/PI3K/Akt pathway, and these findings could be a valid molecular target for liver cancer therapy.
genetics_knock down_promote	34124998	hsa-mir-425	Stomach Neoplasms	This study aim to investigate the role of miR-425 in gastric cancer.The expression of miR-425 and Dickkopf-related protein-3(DKK-3) were analyzed by qRT-PCR.
transcription factor target	34124983	hsa-mir-195	Stomach Neoplasms	5p or elevated PD-L1 expression reverses the inhibitory effect of AS-IV on EMT and angiogenesis of GC cells.
genetics_knock down_promote	34124974	hsa-mir-877	Squamous Cell Carcinoma of Head and Neck	5p.Hsa_circ_0042823 promotes proliferation, migration, invasion of LSCC cells.Hsa_circ_0042823 knockdown inhibits tumour growth of LSCC via miR
genetics_knock down_promote	34124372	hsa-mir-431	Colorectal Neoplasms	circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431.
other	34124194	hsa-mir-3	Plaque, Atherosclerotic	The analysis from atherosclerotic plaque revealed that Rb(1) treatment could result in an induction of Pigment epithelium-derived factor (PEDF) expression and reduction of the miR-33 generation.
transcription factor target	34124194	hsa-mir-3	Inflammation	The anti-angiogenic and anti-inflammation effects of Rb(1) are exerted via the modulation of miR-33 and its target gene PEDF.
circRNA target	34124144	hsa-mir-132	Nasopharyngitis	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-145	Nasal Polyps	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-27b	Nasal Polyps	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-27b	Nasopharyngitis	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-146a	Nasal Polyps	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-132	Nasal Polyps	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-145	Nasopharyngitis	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
circRNA target	34124144	hsa-mir-146a	Nasopharyngitis	"GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR"
transcription factor target	34124097	hsa-mir-1	Ameloblastoma	3p suppressed malignant phenotypes of AB through down-regulating LAMP2-mediated autophagy, which could become an underlying target for AB therapy.
exosome	34124064	hsa-mir-1305	Stomach Neoplasms	In conclusion, our results indicated a previously unknown regulatory pathway in which exosomal circ_0088300 derived from CAFs acts as a sponge of miR-1305 and promotes GC cell proliferation, migration and invasion; these data identify a potential biomarker and novel therapeutic target for GC in the future.
exosome	34124036	hsa-mir-6515	Osteoarthritis	CONCLUSION: Exosomes may alleviate OA inflammation by regulating the LYRM4-AS1/GRPR/miR5p signaling pathway.
transcription factor target	34123589	hsa-mir-568	Spinal Cord Ischemia	Moreover, inhibition of miR-3568 preserved hind limb function after SCII by reducing apoptosis, possibly through regulating GATA6, GATA4, and RBPJ in SCII.
circulation_biomarker_diagnosis_ns	34123418	hsa-mir-20a	Obesity	The expression of MALAT1 and miR-320a was correlated with the changes in the anthropometric and blood indices of obese children and adolescents, and their correlations with endothelial dysfunction markers were obtained.
other	34123373	hsa-mir-192	dystonia 5	These sensors showed a linear response to buffered miR-21, with a 17 fM limit of detection, and successfully discriminated between urine samples (n = 6) from DKD patients and unaffected control subjects (n = 6) by differential miR-192 detection.
other	34123373	hsa-mir-21	dystonia 5	These sensors showed a linear response to buffered miR-21, with a 17 fM limit of detection, and successfully discriminated between urine samples (n = 6) from DKD patients and unaffected control subjects (n = 6) by differential miR-192 detection.
lncRNA target	34122636	hsa-mir-145	Thymus Neoplasms	In conclusion, si-MALAT1 significantly attenuated cell proliferation and apoptosis via the miR5p/HMGA2 pathway in thymic cancer cells.
circulation_biomarker_prognosis_ns	34122634	hsa-mir-135a	Colonic Neoplasms	The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC).
circulation_biomarker_prognosis_ns	34122634	hsa-mir-135	Colonic Neoplasms	The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC).
target gene	34122631	hsa-mir-497	Triple Negative Breast Neoplasms	miR-497 inhibits proliferation and invasion in triple-negative breast cancer cells via YAP1.
target gene	34122630	hsa-mir-768	Breast Neoplasms	Decreased microRNA-768-3p expression indicates a poor prognosis in patients with breast cancer and promotes breast cancer cell viability, migration and invasion.
other	34122628	hsa-mir-588	Colorectal Neoplasms	In addition, western blot analysis indicated that the effect of SNHG8 on autophagy in CRC cells was dependent on the miR-588/ATG7 axis.
exosome	34122615	hsa-mir-224	Carcinoma, Renal Cell	5p can enter ccRCC cells via CAF-derived exosomes, in turn, promoting the malignant behaviors of ccRCC cells, which indicates that miR
target gene	34122108	hsa-mir-382	Ovarian Neoplasms	Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer.
target gene	34122108	hsa-mir-382	Breast Neoplasms	Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer.
circulation_biomarker_diagnosis_up	34122072	hsa-mir-20a	Pulmonary Embolism, Acute	Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form.
circulation_biomarker_diagnosis_up	34122072	hsa-mir-20a	Familial Primary Pulmonary Hypertension	Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form.
circulation_biomarker_diagnosis_up	34122072	hsa-let-7i	Familial Primary Pulmonary Hypertension	Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form.
circulation_biomarker_diagnosis_up	34122072	hsa-let-7i	Pulmonary Embolism, Acute	Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form.
circulation_biomarker_diagnosis_ns	34121556	hsa-mir-340	Glomerulonephritis, Membranous	5p and TNF-alpha (or IL-6) content in serum of GN rats.
genetics_overexpression_promote	34121515	hsa-mir-218	Glioma	Moreover, cell experiments validated that overexpressed TCF12 could promote the proliferation, migration, and invasion of glioma cells and inhibit their apoptosis, whereas overexpressing miR
transcription factor target	34121490	hsa-mir-134	Inflammation	Inflammation and oxidative stress were increased in H(2)O(2)-induced PC12 cells but improved with DEX or miR-134 inhibitor treatment.
lncRNA target	34121317	hsa-mir-211	Depression	5p/Dyrk1A pathway may be critically involved in the pathogenesis of depression and serve as a potential therapeutic target for the treatment of depression.
genetics_overexpression_promote	34121238	hsa-mir-626	Squamous Cell Carcinoma of Head and Neck	Overexpressed RASSF4 inhibited the proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of OSCC cells, promoted cell apoptosis, and blocked the Wnt/beta-Catenin pathway, which was reversed by miR-626 overexpression.
genetics_knock down_promote	34121038	hsa-mir-877	Osteosarcoma	The knockdown of miR-877 promoted the migration and invasion and facilitated the proliferation of Saos-2 and U2OS cells, and the silence of GGCT abolished this effects.
lncRNA target	34120890	hsa-mir-513b	Carcinoma, Hepatocellular	MiR-513b-5p may be applied as a therapeutic target for HCC.
other	34120462	hsa-mir-130a	Osteoarthritis	Aim: To investigate whether kaempferol exhibited protective effects on osteoarthritis chondrocytes by modulating the XIST/miR-130a/STAT3 axis.
genetics_knock down_promote	34120407	hsa-mir-144	Acute Lung Injury	Using gain- and loss-of-function approaches, we analysed the effects of miR-144 and its interaction with KLF2 on TRALI.
lncRNA target	34120306	hsa-mir-17	Cardiomegaly	kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and regulating autophagy.
exosome	34120145	hsa-mir-580	Breast Neoplasms	Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress.
circulation_biomarker_diagnosis_ns	34119828	hsa-mir-129	Diabetes Mellitus	The exosomes isolated from the blood of DM rats showed more miR
other	34119822	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	In general, our study demonstrated a novel regulatory mechanism that circ_0001461/miR-145/TLR4/NF-kappaB axis modulates oral squamous cell carcinoma progression.
transcription factor target	34118948	hsa-mir-1224	Ischemic Stroke	Among those miRNAs, miR-1224 markedly increased 3 days after ischemic stroke. Passive transfer of NK cells treated with an miR-1224 inhibitor prevented the accumulation of a bacterial burden in the lungs after ischemic stroke, suggesting an enhanced immune defense of NK cells.
other	34118888	hsa-mir-3158	Carcinoma, Hepatocellular	5p and -548as-3p) significantly correlated with the development of HCC, which can be present as biomarkers after further completing studies.
lncRNA target	34118875	hsa-mir-143	Tracheal Stenosis	The MIR143HG/miR-1275/ILK axis mediates beta-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis.
lncRNA target	34118875	hsa-mir-1275	Tracheal Stenosis	The MIR143HG/miR-1275/ILK axis mediates beta-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis.
transcription factor target	34118643	hsa-mir-486	Parkinson Disease	5p gene targets for PD onset and progression.
lncRNA target	34118183	hsa-mir-181b	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118183	hsa-mir-195	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118183	hsa-mir-146b	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118183	hsa-mir-1	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118183	hsa-mir-181b-2	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118183	hsa-mir-181b-1	Dwarfism, Pituitary	The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways.
lncRNA target	34118141	hsa-mir-124	Cognition Disorders	OBJECTIVES: In the current study, we investigated if miR-124 can offer protection against cognitive deficits induced by sevoflurane in a spatial learning paradigm, and examined the molecular mechanisms through cell cultures.
lncRNA target	34118139	hsa-mir-197	Gallbladder Neoplasms	Downregulation of miR-197 inhibited the proliferation and promoted the apoptosis of GBC cells, indicating potential therapeutic effects.
transcription factor target	34117764	hsa-mir-133a	Esophageal Neoplasms	MiR-133a-3p is a crucial tumour suppressor miRNA in EC, playing a tumour suppressor role by targeting CDCA8.
lncRNA target	34117688	hsa-mir-214	Squamous Cell Carcinoma of Head and Neck	In this article, we report circFOXO3 promotes tumor growth and invasion of OSCC by targeting miR-214 which specifically degrades the lysine demethylase 2A (KDM2A). Collectively, our results proved that circFOXO3 sponges miR-214 to up-regulate the expression of KDM2A, thus promotes tumor progression in OSCC.
genetics_knock down_suppress	34117619	hsa-mir-124	Glioma	In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells.
lncRNA target	34117611	hsa-mir-130b	Melanoma	Together, these data suggest the potential of miR-130b-3p to inhibit ferroptosis in melanoma cells and the mechanism was related to DKK1-mediated Nrf2/HO-1 pathway.
genetics_knock down_suppress	34117589	hsa-mir-15a	Endometriosis	Knockdown of circ_0075503 inhibited E2-induced enhancement of cell migration and invasion in eutopic ESCs by regulating miR-15a-5p/KLF12 axis, indicating a novel target for the treatment of endometriosis.
exosome	34117264	hsa-mir-636	Prostatic Neoplasms	In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636.
exosome	34117264	hsa-mir-451	Prostatic Neoplasms	In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636.
exosome	34117264	hsa-mir-16	Prostatic Neoplasms	In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636.
exosome	34117264	hsa-mir-21	Prostatic Neoplasms	In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636.
exosome	34117264	hsa-mir-142	Prostatic Neoplasms	In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636.
genetics_knock down_promote	34116704	hsa-mir-361	Ovarian Neoplasms	Rescue experiments revealed that LINC00922 knockdown inhibited OC cell proliferation, migration, invasion and EMT by regulating miR
genetics_overexpression_promote	34116691	hsa-mir-889	Carcinoma, Hepatocellular	CONCLUSIONS: Overall, miR-889 was upregulated in hepatocellular carcinoma tissues and cell lines, and overexpression of miR-889 promoted cell proliferation, migration, and invasion in hepatocellular carcinoma cells.
lncRNA target	34116684	hsa-mir-24	Osteoarthritis	CONCLUSIONS: In conclusion, our work provides important insight into targeting miR
genetics_overexpression_promote	34116237	hsa-mir-29b	Muscular Atrophy	The protective effects of exercise in Ang-induced muscle atrophy were inhibited by a PPARgamma inhibitor (T0070907) or adeno-associated virus serotype-8 (AAV8)-mediated miR-29b overexpression.
other	34116070	hsa-mir-532	Hypertension	BACKGROUND: This study was carried out to investigate the effect of microRNA miR5p on the proliferation of hypertension endothelial cells.
lncRNA target	34115574	hsa-mir-223	Sepsis	Our findings indicate MKNK1, one targets of miR
genetics_overexpression_suppress	34115555	hsa-mir-126	Sepsis	In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappaB signaling pathway activity.
genetics_overexpression_suppress	34115555	hsa-mir-126	Brain Injuries	In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappaB signaling pathway activity.
genetics_overexpression_promote	34115554	hsa-mir-509	Carcinoma, Hepatocellular	3p overexpression causes inhibition of the proliferation, migration, invasion and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis.
lncRNA target	34115526	hsa-mir-326	Myocardial Infarction	Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression.
lncRNA target	34115526	hsa-mir-143	Myocardial Infarction	Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression.
lncRNA target	34115526	hsa-mir-144	Myocardial Infarction	Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression.
genetics_overexpression_promote	34115460	hsa-mir-379	Endometrial Neoplasms	The results showed that overexpression of miR
tissue_expression_ns	34115333	hsa-mir-485	Breast Neoplasms	5p and upregulation of FLOT1 were capable of reversing the anticancer activities of A1BG-AS1 deficiency in terms of breast cancer cell malignancy.
lncRNA target	34115289	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	LncRNA CCDC144NL-AS1 can be used as an oncogene of NSCLC to predict patient prognosis and promote tumor proliferation, migration, and invasion by targeting miR3p.
transcription factor target	34115259	hsa-mir-133a	Kidney Failure, Chronic	Our findings provide insight into the potential use of miR-133a as a molecular target for diagnosing vascular calcification in end-stage renal disease.
transcription factor target	34114971	hsa-mir-187	salivary gland adenoid cystic carcinoma	Conjointly, our data revealed that CXCR5 facilitated PNI through downregulating miR-187 to disinhibit S100A4 expression in SACC.
lncRNA target	34114917	hsa-mir-210	Brain Injuries	However, there is no effective therapy for hypoxia-induced injury or OSAHS due to the elusive mechanism involved.Objective: This study aimed to assess the effects of paeoniflorin on hypoxia-induced injury and explore the underlying mechanism.Materials and methods: Hypoxic models of SD rats and CTX-TNA2 cells were used to assess the effect of paeoniflorin, and the expressions of hif1a, miR-210, caspase1 and GSDMD were detected using western blots and RT-PCR. After transfection of miR-210 mimics, the attenuation of pyroptosis induced by paeoniflorin was suppressed, which was accompanied by an increase of ROS levels, as well as LDH release, indicating a critical role of miR-210 in pyroptosis in astrocytes.Conclusions: Our findings demonstrated that paeoniflorin improved hypoxia-induced pyroptosis in astrocytes via depressing hif1a/miR-210/caspase1/GSDMD signaling, providing robust evidence for the treatment of hypoxic injury and OSAHS.HighlightsHypoxia induces severe injury and inflammatory response in the rat brain;Hypoxia enhanced pyroptotic level and led to an activation of astrocytes.;Paeoniflorin alleviates hypoxia-induced pyroptosis in astrocytes;Transfection of miR-210 mimics suppressed the effects of paeoniflorin on hypoxia-induced pyroptosis in astrocytes.
other	34114724	hsa-mir-146a	Acute Lung Injury	Moreover, STAT3 combined the promoter region of XIST to accelerate the transcription, constituting the positive feedback loop of XIST/miR-146a-5p/STAT3 in ALI.
transcription factor target	34114688	hsa-mir-31	Diabetic Foot	3p were found upregulated specifically in iPSC-derived diabetic fibroblasts, while their targets CAV1 and CDKN3 were suppressed.
transcription factor target	34114688	hsa-mir-197	Diabetic Foot	3p were found upregulated specifically in iPSC-derived diabetic fibroblasts, while their targets CAV1 and CDKN3 were suppressed.
lncRNA target	34114479	hsa-mir-498	Esophageal Squamous Cell Carcinoma	miR-498 inhibited MDM2-mediated ATF3 degradation, thus suppressing autophagy and M2-like polarization of macrophages in esophageal cancer.
other	34113619	hsa-mir-181b	Stomach Neoplasms	The CAGE-MiR-181b-5p-S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells.
other	34113568	hsa-mir-214	Lymphoma, Large-Cell, Anaplastic	5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.
lncRNA target	34113564	hsa-mir-378a	Breast Neoplasms	Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation.
lncRNA target	34113562	hsa-mir-20b	Colorectal Neoplasms	Mechanistically, through interacting with miR-320b in CRC, DLEU1 promoted the level of PRPS1 which was a target of miR-320b.
virus_miRNA	34113444	hsv1-mir-H1	Esophageal Sphincter, Lower	in the LES of patients with achalasia, hsv1-miR-H1 was overexpressed
genetics_overexpression_promote	34113395	hsa-mir-34a	pancreatic adenocarcinoma	In PAAD cells, overexpression of IUR and miR-34a led to decreased invasive and migratory abilities.
lncRNA target	34113393	hsa-mir-138	Glioma	Thus, SNHG7 may enhance glioma proliferation via modulating the miR5p/EZH2 signaling axis.
lncRNA target	34113391	hsa-mir-219a	Gallbladder Neoplasms	In addition, transfection with microRNA (miRNA/miR)-219a-5p inhibitor rescued short hairpin RNA-circMTO1-inhibited tumorigenesis of GBC cells, suggesting that miR-219a-5p acts as a downstream effector for circMTO1. Taken together, the results of the present study provide novel insight for the role of circMTO1-induced GBC tumorigenesis via regulation of miR-219a-5p expression.
circulation_biomarker_diagnosis_ns	34113163	hsa-mir-22	Cystadenocarcinoma, Serous, Ovarian	5p in blood suggested the migration risk of ovarian cancer.
transcription factor target	34113148	hsa-mir-200a	Diabetic Retinopathy	CONCLUSION: Our results demonstrated that miR-200a could be used as a potential therapy target through down-regulating PDLIM1 in DR.
other	34113144	hsa-mir-146b	Insulin Resistance	Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway.
target gene	34113143	hsa-mir-140	Insulin Resistance	miR-140-5p Aggravates Insulin Resistance via Directly Targeting GYS1 and PPP1CC in Insulin-Resistant HepG2 Cells.
target gene	34113130	hsa-mir-183	Carcinoma, Hepatocellular	miR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis.
genetics_overexpression_promote	34113129	hsa-mir-340	Retinoblastoma	Moreover, overexpression of WIF1 could repress retinoblastoma progression induced by miR-340 in vitro and in vivo.
target gene	34113122	hsa-mir-551b	Carcinoma, Non-Small-Cell Lung	LncRNA PVT1 Facilitates Proliferation, Migration and Invasion of NSCLC Cells via miR-551b/FGFR1 Axis.
circulation_biomarker_diagnosis_ns	34113113	hsa-mir-497	Myocardial Infarction	The diagnostic value of plasma miRNA-497, cTnI, FABP3 and GPBB in pediatric sepsis complicated with myocardial injury was analyzed.
circulation_biomarker_diagnosis_ns	34113113	hsa-mir-497	Neonatal Sepsis	The diagnostic value of plasma miRNA-497, cTnI, FABP3 and GPBB in pediatric sepsis complicated with myocardial injury was analyzed.
genetics_overexpression_promote	34113109	hsa-mir-130a	Intracranial Aneurysm	CONCLUSION: SAMMSON is overexpressed in IA and suppresses VSMC proliferation via inhibiting miR-130a maturation.
other	34112885	hsa-mir-506	Extra-Hepatic Portal Venous  Obstruction 	3p were higher in children with EHPVO than healthy group.
other	34112885	hsa-mir-124	Extra-Hepatic Portal Venous  Obstruction 	3p were higher in children with EHPVO than healthy group.
circulation_biomarker_prognosis_up	34112884	hsa-mir-451a	Gallbladder Neoplasms	Serum EVs miR-1246 and miR-451a were significantly upregulated and downregulated, respectively in GBC patients (P=0.005 and P=0.001), in line with their expression levels in cancer tissue according to an in silico analysis. Taken together, miR-1246 in serum EVs has potential application as a diagnostic and prognostic marker and miR-451a may be a novel therapeutic target in GBC.
other	34112774	hsa-mir-375	Prostatic Neoplasms	3p) from prostate cancer patients with active disease and in remission.
other	34112774	hsa-mir-141	Prostatic Neoplasms	3p) from prostate cancer patients with active disease and in remission.
other	34112731	hsa-mir-193b	Sepsis	Finally, the clinical significance of these results was supported by the finding of increased miR-193b-5p expression levels in lung autopsy samples from acute respiratory distress syndrome patients who died with diffuse alveolar damage.
other	34112731	hsa-mir-193b	Acute Lung Injury	Finally, the clinical significance of these results was supported by the finding of increased miR-193b-5p expression levels in lung autopsy samples from acute respiratory distress syndrome patients who died with diffuse alveolar damage.
lncRNA target	34112319	hsa-mir-132	Aortic Valve Stenosis	OBJECTIVES: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart failure development in this model. CONCLUSIONS: The inhibition of miR-132 is a valid strategy in prevention of heart failure progression in hypertrophic heart disease and may be developed as a treatment for heart failure of nonischemic origin.
lncRNA target	34112319	hsa-mir-132	Heart Failure	OBJECTIVES: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart failure development in this model. CONCLUSIONS: The inhibition of miR-132 is a valid strategy in prevention of heart failure progression in hypertrophic heart disease and may be developed as a treatment for heart failure of nonischemic origin.
circulation_biomarker_diagnosis_up	34112294	hsa-mir-1	Coronary Disease	CONCLUSIONS: Circulating miR-1 might have the value for early diagnosis of coronary artery plaque rupture in SCAD patients.
circulation_biomarker_diagnosis_up	34112294	hsa-mir-1	Plaque, Atherosclerotic	CONCLUSIONS: Circulating miR-1 might have the value for early diagnosis of coronary artery plaque rupture in SCAD patients.
target gene	34112163	hsa-mir-503	Liver Neoplasms	Echinacoside exerts anti-tumor activity via the miR-503-3p/TGF-β1/Smad aixs in liver cancer.
genetics_overexpression_promote	34112159	hsa-mir-493	Glioma	Functionally, the overexpression of circNALCN significantly inhibited the proliferation and migration of glioma cells, whereas miR
other	34112152	hsa-mir-106a	Asthma	EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively).
other	34112152	hsa-mir-146a	Asthma	EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively).
other	34112152	hsa-mir-126a	Asthma	EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively).
circulation_biomarker_diagnosis_ns	34112145	hsa-mir-20a	Lymphoma, Large B-Cell, Diffuse	the regulation of miR-320a/XBP1 axis through LINC00963 for endoplasmic reticulum stress and autophagy in diffuse large B-cell lymphoma.
lncRNA target	34111659	hsa-mir-26a	Kidney Diseases	Herein, we described the discovery path of Se-Y antagonism in Cd-induced renal necroptosis in chicken through targeting miR-26a-5p/PTEN/PI3K/AKT signaling pathway. Taken together, our results showed that Se-Y has an added value to antagonize Cd-induced necroptosis in chicken kidney by regulating the miR-26a-5p/PTEN/PI3K/AKT signaling pathway and HSPs, indicating that Se-Y could serve as an effective antagonist on Cd-induced renal necroptosis in chickens.
lncRNA target	34111466	hsa-mir-431	Hepatitis, Autoimmune	5p may be a potential therapeutic target for AIH.
genetics_overexpression_suppress	34111240	hsa-mir-128a	Leukemia, Myelomonocytic, Acute	We show that miR-130b and miR-128a are downstream targets of MLL-AF4 and can individually drive the transition from a pre-leukemic stage to an acute leukemia in an entirely murine Mll-AF4 in vivo model. Interestingly, miR-130b overexpression led to a mixed/B-cell precursor (BCP)/myeloid leukemia, propagated by the lymphoid-primed multipotent progenitor (LMPP) population, whereas miR-128a overexpression resulted in a pro-B acute lymphoblastic leukemia (ALL), maintained by a highly expanded Il7r+c-Kit+ blast population.
genetics_overexpression_suppress	34111240	hsa-mir-130b	Leukemia, Myelomonocytic, Acute	We show that miR-130b and miR-128a are downstream targets of MLL-AF4 and can individually drive the transition from a pre-leukemic stage to an acute leukemia in an entirely murine Mll-AF4 in vivo model. Interestingly, miR-130b overexpression led to a mixed/B-cell precursor (BCP)/myeloid leukemia, propagated by the lymphoid-primed multipotent progenitor (LMPP) population, whereas miR-128a overexpression resulted in a pro-B acute lymphoblastic leukemia (ALL), maintained by a highly expanded Il7r+c-Kit+ blast population.
genetics_knock down_promote	34110962	hsa-mir-125b	Pancreatic Carcinoma	Furthermore, the effects of MIR210HG knockdown on HK2 and PKM2 expression, pancreatic cancer cell aggressive phenotypes, and glycolysis were significantly reversed by miR-125b-5p inhibition.
exosome	34110633	hsa-mir-135a	Colorectal Neoplasms	Exosomal miR-135a-5p initiated the large tumor suppressor kinase 2-yes-associated protein-matrix metalloproteinase 7 axis to promote the occurrence of CRC liver metastasis, and cluster of differentiation 30-TNF receptor-associated factor 2-p65-mediated immunosuppression signaling also contributed to this process. CONCLUSIONS: Hypoxia-induced exosomal miR-135a-5p correlates with the development, clinical severity, and prognosis of CRC liver metastases through the premetastatic niche; and our findings revealed that miR-135a-5p might be a promising target in halting CRC liver metastases.
transcription factor target	34110576	hsa-mir-34c	Cardiovascular Diseases	The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-beta/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease.
other	34110382	hsa-mir-103	Stomach Neoplasms	In the present study, we aimed to clarify the association of CYTOR, miR-103, and RAB10 in gastric cancer progression. These findings suggest that the CYTOR/miR-103/RAB10 axis is a novel signaling pathway that facilitates gastric cancer progression.
genetics_overexpression_promote	34110366	hsa-mir-23b	Glioma	In addition, we demonstrated that overexpression of TLR4 abrogated the regulatory function of miR-23b-5p in glioma cells on cell proliferation, cell apoptosis, and the chemosensitivity of TMZ treatment.
other	34110104	hsa-mir-205	Carcinoma, Hepatocellular	RESULTS: YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b-ZEB1 axis partially in a Snail-independent manner. CONCLUSION: This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b-ZEB1 axis in HCC cells.
other	34110104	hsa-mir-200b	Carcinoma, Hepatocellular	RESULTS: YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b-ZEB1 axis partially in a Snail-independent manner. CONCLUSION: This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b-ZEB1 axis in HCC cells.
other	34109708	hsa-mir-424	Pneumonia, Mycoplasma	RESULTS: The expression level of linc00473 was low and miR5p was high in placenta of PE patients.
lncRNA target	34109707	hsa-mir-520g	Rhabdomyosarcoma 1	Our data revealed that IGF2-AS and N-cadherin levels were notably decreased, and miR-520g was strikingly increased in the placentas from RM patients. CONCLUSIONS: These findings indicated that IGF2-AS facilitated trophoblast cell proliferation, migration, invasion, EMT, and suppressed cell apoptosis by regulating miR-520g/N-cadherin axis, providing potential biomarkers for RM.
lncRNA target	34109575	hsa-mir-340	Osteosarcoma	5p repressed the malignant phenotypes of OS via targeting NRF2 and regulating PI3K/AKT pathway and EMT.
other	34109431	hsa-mir-200b	Lung Neoplasms	In the present study, miR200b expression was found to be increased in cigarette smoke (CS)exposed BEAS2B cells, lung cancer cell lines and tumor tissue samples.
transcription factor target	34109430	hsa-mir-142	Colorectal Neoplasms	Decreased expression of miR1423p may be associated with CRC tumorigenesis via Rac1ERK signaling.
transcription factor target	34109426	hsa-mir-199a	Brain Ischemia	However, the association between DEX and miR199a in CIR injury remains unknown. In conclusion, DEX inhibited expression of miR199a and improved neurocyte injury induced by CIR.
genetics_overexpression_promote	34109425	hsa-mir-451	Colorectal Neoplasms	Overexpression of miR451 inhibited proliferation and migration, promoted apoptosis and enhanced the sensitivity of CRC cells to chemotherapy.
lncRNA target	34109193	hsa-mir-23a	Colorectal Neoplasms	Materials and Methods: Quantitative real-time polymerase chain reaction was used to determine the expression levels of EBLN3P and miR-323a-3p in CRC tissues and cell lines. Conclusion: EBLN3P promoted the development of CRC via targeting miR-323a-3p/UHMK1, which provided a new idea for treating CRC.
other	34108628	hsa-mir-224	Colonic Neoplasms	In this research, a novel zinc-based nanoscale metal-organic framework (Zn-NMOF) coated with folic acid (FA) functionalized chitosan (CS) has been constructed and applied as efficient delivery of LNA (locked nucleic acid)-antisense miR-224 to colon cancer cell lines.
lncRNA target	34108451	hsa-mir-138	Carcinoma, Hepatocellular	5p/PTK2/Akt axis in HCC cells, indicating CircC16orf62 can be a therapeutic target with potentiality for liver cancer and a predictive marker for people with HCC.
circulation_biomarker_diagnosis_up	34108361	hsa-mir-34a	Cerebral Hemorrhage	ICH rat models were established utilizing the autologous blood injection method and the beneficial effect was found after DU20-penetrating-GB7 acupuncture along with decreased miR-34a-5p levels in the perihemorrhagic penumbra.
lncRNA target	34108309	hsa-mir-345	Thyroid Cancer, Papillary	5p suppressed PTC cell growth and motility via regulating FZD8.
other	34107956	hsa-mir-148b	Colorectal Neoplasms	Expression of DDIT4, TPTEP1, and miR-181d-5p showed significantly increased levels while SULF1 and miR-148b-3p showed decreased levels in CRC tissues compared to the adjacent normal tissues.
other	34107956	hsa-mir-181d	Colorectal Neoplasms	Expression of DDIT4, TPTEP1, and miR-181d-5p showed significantly increased levels while SULF1 and miR-148b-3p showed decreased levels in CRC tissues compared to the adjacent normal tissues.
genetics_overexpression_promote	34107856	hsa-mir-6734	Carcinoma, Non-Small-Cell Lung	3p overexpression on NSCLC progression were abrogated by upregulating ZEB2.
transcription factor target	34107852	hsa-mir-362	Diabetes, Gestational	5p might be a therapy target of GDM.
lncRNA target	34107580	hsa-mir-23b	Carcinoma, Hepatocellular	Conclusion: miR-23b can inhibit the proliferation, migration, invasion and vasculogenic mimicry formation, and enhance the sensitivity of lenvatinib drug in human hepatocellular carcinoma cells.
genetics_overexpression_promote	34107348	hsa-mir-214	Osteoarthritis	In addition, overexpressed miR
lncRNA target	34107168	hsa-mir-221	Lung Neoplasms	3p to hamper both tumour growth and metastasis could be a new therapeutic approach for lung cancer.
lncRNA target	34107168	hsa-mir-126	Lung Neoplasms	3p to hamper both tumour growth and metastasis could be a new therapeutic approach for lung cancer.
transcription factor target	34107032	hsa-mir-7	Parkinson Disease	Importantly, miR-7's primary target is an mRNA of alpha-synuclein, which contributes to the aetiology of Parkinson's disease.
circulation_biomarker_diagnosis_ns	34107000	hsa-mir-275	Trypanosomiasis	This system induces a constitutive, 40% reduction in miR275 transcript abundance in the fly's midgut and results in obstructed blood digestion (gut weights increased by 52%), a significant increase (p-value < 0.0001) in fly survival following infection with an entomopathogenic bacteria, and a 78% increase in trypanosome infection prevalence.
lncRNA target	34106877	hsa-mir-500b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	In vitro experiments suggested that LINC01278 promoted the proliferation of leukemic cells and inhibited leukemic cell apoptosis by targeting the inhibition of miR-500b-3p in cALL, and LINC01278 may be a biological target for the treatment of cALL in the future.
circulation_biomarker_diagnosis_ns	34106501	hsa-mir-142	Tuberculosis	CONCLUSIONS: Integrating serum miR
circulation_biomarker_diagnosis_ns	34106260	hsa-let-7b	Crohn Disease	Furthermore, CD changed the miRNA profile of exosomes and further analysis revealed a differential expression of let-7b-5p. Furthermore, serum exosome-mediated let-7b-5p-mimic delivery may significantly alleviate colitis, providing potential novel insight into an exosome-based strategy for the diagnosis and treatment of CD.
genetics_GWAS	34105828	hsa-mir-455	Liver Cirrhosis	Thus, the epigenetics mediated miR
circulation_biomarker_prognosis_up	34105500	hsa-mir-194	Graft vs Host Disease	The expressions of plasma miR-181b and miR-194 collected on day 15 after HSCT were significantly upregulated in the patients with aGVHD in comparison with non-GVHD patients (P<0.05).
genetics_GWAS	34105469	hsa-mir-155	Lymphoma, Large B-Cell, Diffuse	The relative expression of miR-155 and the polymorphism of MyD88 L265P were associated with lesion location, stage, BCL-2 protein expression and MyD88 protein expression in DLBCL patients (t=7.4618.8046.48710.812 2=10.6818.5997.25123.008P<0.05).
other	34105224	hsa-mir-211	Glioblastoma	5p/YY1 regulatory signaling axis in GBM.
other	34104831	hsa-mir-155	Coronary Artery Disease	Relevance for Patients Although further investigations are needed to confirm the role of miRNA-155 and miRNA-126, they may serve as potential biomarkers detecting severity of CAD, lowering of kidney function and metabolic syndrome.
circulation_biomarker_diagnosis_ns	34104831	hsa-mir-145	Coronary Artery Disease	Background and Aim Plasma circulating microRNA (miRNA)-126, -145, and -155 are associated with vascular remodeling, atherosclerotic lesion formation, and plaque vulnerability.
other	34104831	hsa-mir-126	Coronary Artery Disease	Relevance for Patients Although further investigations are needed to confirm the role of miRNA-155 and miRNA-126, they may serve as potential biomarkers detecting severity of CAD, lowering of kidney function and metabolic syndrome.
lncRNA target	34104112	hsa-mir-146a	Spinal Cord Injuries	In the present study, our results demonstrated that EZH2 could mediate miR-146a-5p/HIF-1alpha to alleviate the inflammation and glycolysis after ASCI.
genetics_GWAS	34104082	hsa-mir-192	Endometrial Neoplasms	5p is a tumor suppressor miRNA that is epigenetically silenced by promoter methylation and may serve as a potential prognostic biomarker in EC.
genetics_knock down_suppress	34103997	hsa-mir-760	Osteosarcoma	Moreover, EZH2 was identified as the target gene of miR-760 and EZH2 overexpression abolished miR
target gene	34103994	hsa-mir-155	Urinary Bladder Neoplasms	LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p.
genetics_overexpression_suppress	34103991	hsa-mir-136	Carcinoma, Squamous Cell, Cutaneous	5p on CSCC cell progression could be reversed by PRAF2 overexpression.
genetics_overexpression_promote	34103986	hsa-mir-10a	Colorectal Neoplasms	CONCLUSION: circFAT1 is overexpressed in CRC and may suppress CRC cell proliferation, invasion and migration by increasing miR-10a maturation.
lncRNA target	34103911	hsa-mir-485	Pulmonary Disease, Chronic Obstructive	CONCLUSION: These findings elucidated that circ-HACE1 contributed to the CSE-induced cell damages in COPD cell models via regulating TLR4 by acting as the sponge of miR3p.
lncRNA target	34103010	hsa-mir-654	Atherosclerosis	3p inhibitor significantly reversed the inhibitory effects of si-TP73-AS1 on cell viability and apoptosis.
other	34102907	hsa-mir-132	Mouth Neoplasms	CONCLUSION: circVAPA is highly expressed in oral cancer, and its abnormal expression might affect the proliferation, invasion and migration of oral cancer cells by modulating the miR-132/HOXA7 signaling axis.
other	34102651	hsa-mir-576	Carcinoma, Hepatocellular	3p and upregulating HIF-1alpha expression.
lncRNA target	34102644	hsa-mir-488	Spinal Cord Injuries	RESULTS: After SCI induction, rats exhibited low Basso-Beattie-Bresnahan scores, promoted the release of inflammation-related factors and downregulated miR-488. CONCLUSION: MiR-488 inhibited neural inflammation and apoptosis in SCI via its binding with HMGB1-mediated restraint on the TLR4/NF-kappaB signaling pathway.
lncRNA target	34102610	hsa-mir-1303	Osteosarcoma	Furthermore, we identified FGF7 is one direct target gene of miR-1303 in osteosarcoma cell.
transcription factor target	34102226	hsa-mir-892b	Osteoarthritis	CONCLUSION: MiR-892b antagomir inhibits the progression of OA via targeting Cyclin D1 and Cyclin D2.
genetics_knock down_suppress	34102206	hsa-mir-138	Retinoblastoma	5p, and SLC7A5 overexpression abated the anti-tumor roles of miR
other	34101749	hsa-mir-16	Breast Neoplasms	5p is a commonly used IC, it's not a suitable one for breast cancer studies.
transcription factor target	34101749	hsa-mir-361	Breast Neoplasms	5p had lower standard deviation and also was the only IC capable of detecting a significant up-regulation of hsa-miR
other	34101749	hsa-mir-16	Esophageal Squamous Cell Carcinoma	5p and U48 on 34 pairs of Primary breast tumor and their adjacent normal tissues using qRT-PCR.
other	34101749	hsa-mir-361	Esophageal Squamous Cell Carcinoma	5p and U48 on 34 pairs of Primary breast tumor and their adjacent normal tissues using qRT-PCR.
transcription factor target	34101749	hsa-mir-21	Breast Neoplasms	5p had lower standard deviation and also was the only IC capable of detecting a significant up-regulation of hsa-miR
lncRNA target	34101492	hsa-mir-613	Breast Neoplasms	Following transfection with miR-613 mimic, the expression of miR-613 was elevated in the BC cells leading to inhibition of NAMPT expression at both mRNA and protein level as measured by real-time PCR and western blotting, respectively.
lncRNA target	34101281	hsa-mir-26a	Hemorrhage	Mechanistically, miR-26a, which is enriched in SA-Exo, improved angiogenesis both in SHED and HUVECs via regulating TGF-beta/SMAD2/3 signalling. CONCLUSIONS: In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-beta/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration.
circRNA target	34101064	hsa-mir-545	Sepsis	In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI.
circRNA target	34101064	hsa-mir-545	Acute Kidney Injury	In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI.
other	34100730	hsa-mir-146b	Atrial Fibrillation	3p, miR-630, miR-146b-5p, and miR-367 had a potential diagnostic value to discriminate patients with AF from healthy controls in this study.
other	34100730	hsa-mir-367	Atrial Fibrillation	3p, miR-630, miR-146b-5p, and miR-367 had a potential diagnostic value to discriminate patients with AF from healthy controls in this study.
other	34100717	hsa-mir-125	Late Onset Disorders	Our findings identify miR-125 as a conserved effector of the DR pathway and open the avenue for this small RNA molecule and its downstream effectors to be considered as potential drug candidates for the treatment of late-onset diseases and biomarkers for healthy aging in humans.
other	34100450	hsa-mir-488	Spinal Cord Injuries	Furthermore, circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI.
transcription factor target	34100379	hsa-mir-16	Necrobiotic Disorders	Taken together, puerarin alleviates oxidative stress and pyroptosis in HG-stimulated HRECs through regulating the miR- 16-5p/CASP1 axis.
genetics_knock down_suppress	34100377	hsa-mir-671	Arthritis, Rheumatoid	Thus, circ-PTTG1IP knockdown repressed cell proliferation, migration, invasion and inflammatory response in RA-FLSs by regulating the miR
genetics_overexpression_promote	34100183	hsa-mir-29a	Colonic Neoplasms	In addition, colon cancer Caco-2 cells, which constitutively overexpress B7-H3, were transfected with lentivirus particles for miR-29a upregulation.
tissue_expression_up	34100182	hsa-mir-338	Atherosclerosis	3p in the development of AS, VSMC proliferation and migration were evaluated by EdU incorporation assay, MTT assay, and wound healing assay.
genetics_overexpression_promote	34100174	hsa-mir-1298	Lung Injury	5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells (BEAS-2B).
other	34099864	hsa-mir-570	Prostatic Neoplasms	SNV rs9860655 in the mature sequence of miR-570 was not present in benign prostate hyperplasia (BPH) tissue or cell lines but was detectable in clinical prostate cancer tissue samples and adjacent normal tissue.
transcription factor target	34099844	hsa-mir-21	Hyperlipidemias	Taken together, these results demonstrated that aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1, and OLR1.
lncRNA target	34099597	hsa-mir-7	Lung Neoplasms	LINC01272 suppressed cell multiplication and induced apoptosis via regulating the miR5p/CRLS1 axis in LC.
genetics_overexpression_promote	34099038	hsa-mir-378	Femur Head Necrosis	overexpressing ASCs (miR
circulation_biomarker_diagnosis_up	34098850	hsa-mir-221	Squamous Cell Carcinoma of Head and Neck	We used quantitative real-time PCR (qRT-PCR) and western blotting to determine PIK3R1 and miR-221 expressions in OSCC tissue or peripheral blood serum.
other	34098766	hsa-mir-223	ST Elevation Myocardial Infarction	OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI.
other	34098766	hsa-mir-126	ST Elevation Myocardial Infarction	OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI.
genetics_overexpression_promote	34098582	hsa-mir-195	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Key cell cycle regulators were downregulated upon miR-497/195 overexpression, and we identified cyclin-dependent kinase 4 (CDK4)- and cyclin-D3 (CCND3)-mediated control of G1/S transition as a principal mechanism for the suppression of BCP-ALL progression by miR-497/195.
genetics_overexpression_promote	34098582	hsa-mir-497	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Key cell cycle regulators were downregulated upon miR-497/195 overexpression, and we identified cyclin-dependent kinase 4 (CDK4)- and cyclin-D3 (CCND3)-mediated control of G1/S transition as a principal mechanism for the suppression of BCP-ALL progression by miR-497/195.
genetics_overexpression_promote	34098485	hsa-mir-194	Pancreatic Carcinoma	In addition, we found that overexpression of miR
circRNA target	34098264	hsa-mir-6631	Syphilis	5p/DUSP6 crosstalk regulated H(2)S-induced pyroptosis in broilers trachea via ROS generation.
other	34098197	hsa-mir-18a	Prostatic Neoplasms	Taken together, our results suggest that miR-18a-5p might function as a tumor-promoting factor in PCa and might contribute to its proliferation.
genetics_overexpression_promote	34098061	hsa-mir-105	Stomach Neoplasms	Overexpression of miR
lncRNA target	34098015	hsa-mir-744	Pituitary Neoplasms	Taken together, LINC01116 boosted the progression of pituitary adenoma cells via regulating miR
other	34097926	hsa-mir-200a	Reperfusion Injury	In conclusion, our study suggests that circPVT1 protects the myocardium from MI and H/R injury by preventing miR-125b- and miR-200a-mediated apoptotic signaling.
other	34097926	hsa-mir-125b	Reperfusion Injury	In conclusion, our study suggests that circPVT1 protects the myocardium from MI and H/R injury by preventing miR-125b- and miR-200a-mediated apoptotic signaling.
lncRNA target	34097859	hsa-mir-20a	Carcinoma, Non-Small-Cell Lung	ZEB1 transcriptionally inhibited the expression of miR-320a and upregulated the expression of RAD51AP1, thereby promoting metastasis in NSCLC.
other	34097717	hsa-mir-29c	Diabetic Nephropathies	TUG1 regulates miR-29c-3p/SIRT1 and subsequent ERS to relieve high glucose induced renal epithelial cells injury, and suggests a potential role for TUG1 as a promising diagnostic marker of diabetic nephropathy.
lncRNA target	34097562	hsa-mir-181c	Carcinoma, Hepatocellular	Taken together, our study elucidated that ZSCAN16-AS1 expedited HCC progression via modulating the miR-181 c-5p/SPAG9 axis to activate the JNK pathway, which might be a highly potential HCC therapy and treatment target.
circRNA target	34097558	hsa-mir-135b	Arthritis, Rheumatoid	Hsa_circ_0044235 regulated NLRP3-mediated pyroptosis through miR-135b-5p-SIRT1 axis to regulate the development of RA.
genetics_knock down_promote	34097310	hsa-mir-625	Leukemia, Myeloid, Acute	Circ_0012152 knockdown suppressed cell proliferation and promoted death by targeting SOX12 mediated by miR
circulation_biomarker_diagnosis_ns	34097306	hsa-mir-221	Pulmonary Disease, Chronic Obstructive	RESULTS: Chronic obstructive pulmonary disease patients possessed higher serum levels of miR
circulation_biomarker_diagnosis_ns	34097306	hsa-mir-92a	Pulmonary Disease, Chronic Obstructive	RESULTS: Chronic obstructive pulmonary disease patients possessed higher serum levels of miR
lncRNA target	34097192	hsa-mir-424	Liver Neoplasms	5p/ARK5 axis, and thus may serve as a potential target for targeted therapy.
lncRNA target	34096776	hsa-mir-498	Osteosarcoma	Experimental results indicated that miR-498 could directly target LEF1 in OS cells and that circ_0032463 could abrogate the tumor-inhibitory effect of miR-498 by upregulating LEF1 in OS.
circulation_biomarker_diagnosis_up	34096637	hsa-mir-26b	Hepatitis, Alcoholic	During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived.
circulation_biomarker_diagnosis_up	34096637	hsa-mir-146a	Hepatitis, Alcoholic	During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived. Cox regression analysis showed that BMI, MELD score, miR-20a-5p, miR-146a-5p, and miR-26b-5p predicted mortality.
circulation_biomarker_diagnosis_up	34096637	hsa-mir-20a	Hepatitis, Alcoholic	During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived.
lncRNA target	34096570	hsa-mir-27a	Carcinoma, Hepatocellular	Taken together, miR-27a-3p acted as a tumor suppressor gene in HCC cells, and it could be useful for modulating cisplatin sensitivity in chemotherapy.
exosome	34096448	hsa-mir-20a	Lung Neoplasms	Hence, our goal here was to investigate the relevance of miR-320a-containing exosomes from HUCMSCs to lung cancer. Altogether, exosomes carrying miR-320a from HUCMSCs might suppress lung cancer cell growth via the SOX4/Wnt/beta-catenin axis, which highpoints the potency of exosomes expressing miR-320a as a possible therapeutic option for lung cancer treatment.
circRNA target	34096408	hsa-mir-1228	psoriasis 1	CONCLUSIONS: CircRAB3B suppressed psoriasis progression partly through down-regulating miR3p and up-regulating PTEN.
circRNA target	34096368	hsa-mir-646	Diabetic Retinopathy	CONCLUSION: Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment.
circulation_biomarker_diagnosis_ns	34096222	hsa-mir-24	Alzheimer Disease	3p in serums of AD patients and to understand their roles in AD physiopathogenesis by in silico analysis.
circulation_biomarker_diagnosis_ns	34096222	hsa-mir-31	Alzheimer Disease	3p in serums of AD patients and to understand their roles in AD physiopathogenesis by in silico analysis.
lncRNA target	34096221	hsa-mir-373	Pancreatic Carcinoma	dependent SIRT1 inhibition displays anti-proliferative and proapoptotic roles in PC cells via PGC-1alpha/NRF2 pathway, which highlights miR-373 as a potential target for PC treatment.
lncRNA target	34096173	hsa-let-7i	Melanoma	In the in vitro part of the study, Let-7i mimics were transfected and the impact of its restoration on target gene expression, proliferation, migration and apoptosis of SK-MEL-3 melanoma cell line was assessed by real-time PCR and Western blotting, MTT assay, wound-healing assay and flow cytometry, respectively.
circulation_biomarker_diagnosis_ns	34096020	hsa-mir-28	Diabetes Mellitus, Type 2	5p in the plasma may be closely associated with the pathogenesis of T2DM.
circulation_biomarker_diagnosis_ns	34096020	hsa-mir-185	Diabetes Mellitus, Type 2	5p in the plasma may be closely associated with the pathogenesis of T2DM.
lncRNA target	34095625	hsa-mir-22	Instent Restenosis	More importantly, the PCEC@miR-22 coated stents showed reduced inflammation, low switching of SMC phenotype, and low secretion of extracellular matrix, which significantly inhibited IRS.
circulation_biomarker_diagnosis_ns	34095555	hsa-mir-9	psoriasis 1	OBJECTIVES: This study was performed to detect the expression of serum and tissue (lesion and non-lesion) LncRNA MALAT-1 and MiRNA-9 that might be used as biomarkers for psoriasis. CONCLUSION: This study highlights the dysregulation of LncRNA MALAT-1 and miRNA-9 in psoriasis.
genetics_knock down_promote	34095464	hsa-mir-376	Carcinoma, Hepatocellular	Overexpression and knockdown experiments were performed in HCC cells to examine the effects of the SNHG1/miR-376/FOXK1/Snail axis on viability, apoptosis, invasiveness, and migrating abilities.
genetics_knock down_promote	34095464	hsa-mir-376a	Carcinoma, Hepatocellular	Overexpression and knockdown experiments were performed in HCC cells to examine the effects of the SNHG1/miR-376/FOXK1/Snail axis on viability, apoptosis, invasiveness, and migrating abilities.
circulation_biomarker_diagnosis_ns	34095322	hsa-mir-146a	Aortic Valve Insufficiency	Additionally, the miR-146a-5p expression was negatively associated with the SERPINB2 expression in the serum of AR patients. miR-146a-5p and SERPINB2 could be applied as potential targets for AR treatment.
exosome	34095151	hsa-mir-224	Breast Neoplasms	miR-224-5p Carried by Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Regulates Autophagy in Breast Cancer Cells via HOXA5.
lncRNA target	34094954	hsa-mir-494	Prostatic Neoplasms	CONCLUSIONS: Our study reveals that LINC00467 promotes prostate cancer progression via M2 macrophage polarization and the miR3p/STAT3 axis.
other	34094949	hsa-mir-486	Lung Neoplasms	5p exerts in NSCLC, and its expression pattern in the different stages and morphologies of NSCLC makes it a promising biomarker in the early diagnosis of the disease.
transcription factor target	34094932	hsa-mir-139	Stomach Neoplasms	Mechanistically, HOXA13, directly targeted by miR5p in GC, might upregulate ABCC4 expression, thereby accentuating 5-FU resistance of GC cells.
lncRNA target	34094925	hsa-mir-4772	Pancreatic Carcinoma	RESULTS: A prognostic model containing four downregulated miRNAs (hsa-mir-424, hsa-mir-3613, hsa-mir-4772 and hsa-mir-126) related to the prognosis of pancreatic cancer was constructed. Among them, one novel miRNA (hsa-mir-4772) and two novel genes (COL12A1 and COL5A2) associated with pancreatic cancer have great potential to be used as prognostic factors and therapeutic targets for this tumor.
other	34094916	hsa-mir-137	Glioblastoma	We conclude that lncRNA HAS2-AS1 promotes proliferation by functioning as a miR-137 decoy to increase LSD1 levels and thus might be a possible biomarker for GBM.
other	34094909	hsa-mir-96	cervical adenocarcinoma	3p, promoting the MODY activation in cervical ADC.
other	34094909	hsa-mir-96	Uterine Cervical Neoplasms	3p, promoting the MODY activation in cervical ADC.
other	34094909	hsa-mir-28	cervical adenocarcinoma	3p, promoting the MODY activation in cervical ADC.
other	34094909	hsa-mir-28	Uterine Cervical Neoplasms	3p, promoting the MODY activation in cervical ADC.
lncRNA target	34094894	hsa-mir-145	Melanoma	In conclusion, these findings demonstrate that FUT8-AS1 exerts tumor suppressive roles in melanoma via regulating NF90/miR
exosome	34094717	hsa-mir-144	Nasopharyngeal Carcinoma	Notably, miR-144 was identified as a mediator in NPC-EV-induced regulatory effects through the inhibition of the target gene FBXW7 and promotion of the transcriptional factor HIF-1alpha-dependent vascular endothelial growth factor (VEGF-A).
genetics_knock down_suppress	34094712	hsa-mir-98	Mental Disorders	Our findings revealed that the knockdown of lncRNA Xist ameliorates sevoflurane-induced social and emotional impairment through inhibiting neuronal apoptosis and ER stress by targeting the miR
lncRNA target	34094710	hsa-mir-337	Endometrial Neoplasms	Our findings on the MIR210HG-miR3p/137-HMGA2 axis illustrate its potential as a target for endometrial cancer therapeutic development.
other	34094708	hsa-mir-146	Alzheimer Disease	Interestingly, constitutive activation of mTORC1 by Rheb activator restricts proinflammatory cytokine production by reactivating miR-146 miRNPs in amyloid beta-exposed glial cells to rescue the disease phenotype in the in vivo rat model of Alzheimer's disease.
exosome	34094673	hsa-mir-429	Carcinoma, Ovarian Epithelial	Exosomal transfer of miR-429 confers chemoresistance in epithelial ovarian cancer.
target gene	34094665	hsa-mir-206	Hepatoblastoma	βKlotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling.
other	34094547	hsa-mir-221	thyroid gland Hurthle cell carcinoma	Furthermore, in the first case [Hurthle cell carcinoma (HCC)], increased miRNA-221 content was detected, which also indicated malignancy.
other	34094547	hsa-mir-146b	thyroid gland Hurthle cell carcinoma	In the second case (Hurthle cell papillary thyroid carcinoma), an increased level of miRNA-146b was present, which indicated papillary carcinoma.
genetics_overexpression_promote	34093945	hsa-mir-532	Ovarian Neoplasms	5p, and its overexpression could partially offset the influence of miR
circulation_biomarker_prognosis_down	34093857	hsa-mir-138	Breast Neoplasms	5p promoted lung metastasis, and the level of circulating exosomal miR
other	34093839	hsa-let-7c	Stomach Neoplasms	The hsa_circ_0001483/hsa_circ_0001324-hsa-let-7c-PGC axis in GC may account for the down-regulation of PGC in GC tissue.
lncRNA target	34093832	hsa-mir-635	Nasopharyngeal Carcinoma	MiR-635 was demonstrated as a direct target of circRANBP17; circRANBP17 up-regulated RUNX2 expression levels by sponging miR-635, thereby promoting NPC proliferation and invasion.
circRNA target	34093821	hsa-mir-1278	Carcinoma, Non-Small-Cell Lung	In conclusion, we revelaed the vital role of circ0101675-miRWNT3A/5A signaling in NSCLC progression via the competing endogenous RNAs mechanism.
target gene	34093820	hsa-mir-1246	Leukemia	MicroRNA-1246 by Targeting AXIN2 and GSK-3β Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells.
lncRNA target	34093817	hsa-mir-548k	Laryngeal Neoplasms	Moreover, the screened pRS-related ceRNA network and circ_0002951/miR-548k/HAS2 pathway provide potential therapeutic targets and biomarkers of laryngocarcinoma.
genetics_overexpression_promote	34093798	hsa-mir-876	Colorectal Neoplasms	Additionally, LINC01272 or ITGB2 silencing reduced, while miR-876 overexpression promoted, the invasiveness and metastatic capacity of CRC cells in vitro.
other	34093766	hsa-mir-126	Myocardial Reperfusion Injury	PI3K/AKT axis in D-MI/R rats.
other	34093766	hsa-mir-126	Diabetes Mellitus	PI3K/AKT axis in D-MI/R rats.
lncRNA target	34093756	hsa-mir-150	Osteoarthritis	The present study demonstrated that silencing lincRNA-Cox2 expression plays a protective role in OA by enhancing the proliferation and suppressing the apoptosis of chondrocytes, which is related to increased miR-150 expression and activation of the Wnt/beta-catenin pathway.
lncRNA target	34093751	hsa-mir-9	Pancreatitis	However, the role and potential mechanism of miR-9 in AP progression remains unclear. As a result, miR-9 decreased inflammatory response and apoptosis in caerulein-treated AR42J cells by targeting FGF10 and blocking NF-kappaB signaling, suggesting that miR-9 may serve as a novel target for AP treatment.
genetics_overexpression_promote	34093749	hsa-mir-296	Colorectal Neoplasms	HMGA1 was overexpressed in CRC tissues and was inversely correlated with the expression of miR
genetics_overexpression_promote	34093664	hsa-mir-574	Colorectal Neoplasms	3p, and its overexpression reversed the inhibition effect of miR
other	34093662	hsa-mir-15a	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-92a	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-181b	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-590	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-93	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-92a-1	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-25	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
other	34093662	hsa-mir-421	Esophageal Neoplasms	5p were correlated to the shorter survival time in patients with EC.
lncRNA target	34093648	hsa-mir-766	Osteoarthritis	In conclusion, exhausting circ_0136474 could mitigate OA chondrocyte oxidative injury through regulating miR
other	34093646	hsa-mir-181	Diastrophic dysplasia	13bp-Insertion-allele vector (P < 0.05), suggesting the reduced binding capability with miR-181 in DD genotype.
circulation_biomarker_diagnosis_ns	34093203	hsa-mir-29b	Hypercholesterolemia	CONCLUSION: Data suggest that circulating miRNA-30c-5p and miRNA-29b-3p are associated with hypercholesterolemia.
circRNA target	34093041	hsa-mir-21	Neuroblastoma	CONCLUSION: We suggest that circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3 may be cancer suppressor genes, which act by sponging miR-21 in NB.
genetics_GWAS	34092821	hsa-mir-27b	Depression	OBJECTIVE: The objective of this study was to investigate the effect of polymorphisms of the CYP3A4, CYP2C9, CYP3A5, ABCB1, CYP2C19, SCL6A4, and 5-HTR2A genes on the concentration/dose indicator of mirtazapine and on the CYP3A expression level obtained by measuring the miR-27b plasma concentration levels in patients suffering from a recurrent depressive disorder.
genetics_GWAS	34092821	hsa-mir-27b	Alcoholism	OBJECTIVE: The objective of this study was to investigate the effect of polymorphisms of the CYP3A4, CYP2C9, CYP3A5, ABCB1, CYP2C19, SCL6A4, and 5-HTR2A genes on the concentration/dose indicator of mirtazapine and on the CYP3A expression level obtained by measuring the miR-27b plasma concentration levels in patients suffering from a recurrent depressive disorder.
genetics_overexpression_promote	34092750	hsa-mir-224	Rhinitis, Allergic	5p overexpression.
genetics_overexpression_promote	34092745	hsa-mir-346	Hypoadrenocorticism, Familial	MiR-346 overexpression offset circHACE1 elevation-mediated effects on malignant behaviors of differentiated THCA cells.
lncRNA target	34092624	hsa-mir-125a	Finnish lethal neonatal metabolic syndrome	Our findings revealed that circLMF1 deficiency could inhibit cell viability, cell cycle progression, and migration of PDGF-BB stimulated atherosclerosis model partly through the miR-125a-3p/VEGFA or FGF1 axis, suggesting that targeting circLMF1 can be a feasible therapeutic strategy for atherosclerosis.
circulation_biomarker_diagnosis_up	34092606	hsa-mir-762	Colorectal Neoplasms	Conclusions, the present study suggests that circulating miR-762 might be a potential biomarker for upregulation of CRC cell growth and invasion, and may be accompanied by the Wnt/beta-catenin signaling.
circulation_biomarker_prognosis_ns	34092580	hsa-mir-9	Breast Neoplasms	RESULTS: Results showed that serum expression of both miRNAs 9 and 342 can be used for the diagnosis of different types of BC.
transcription factor target	34092292	hsa-mir-520a	Sciatica	The purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine, so as to play a therapeutic role in sciatica. MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.
lncRNA target	34092219	hsa-mir-128	Sepsis	CONCLUSIONS: Overall, down-regulating SNHG16 alleviated the sepsis-mediated ALI by regulating miR
lncRNA target	34092219	hsa-mir-128	Acute Lung Injury	CONCLUSIONS: Overall, down-regulating SNHG16 alleviated the sepsis-mediated ALI by regulating miR
other	34092168	hsa-mir-24	Multiple Myeloma	3p) that could be a potential biomarker of PN.
other	34092168	hsa-mir-24	Peripheral Nervous System Diseases	3p) that could be a potential biomarker of PN.
other	34092168	hsa-mir-22	Multiple Myeloma	3p) that could be a potential biomarker of PN.
other	34092168	hsa-mir-23a	Multiple Myeloma	3p) that could be a potential biomarker of PN.
other	34092168	hsa-mir-22	Peripheral Nervous System Diseases	3p) that could be a potential biomarker of PN.
other	34092168	hsa-mir-23a	Peripheral Nervous System Diseases	3p) that could be a potential biomarker of PN.
other	34092127	hsa-mir-20b	Ovarian Neoplasms	Our findings suggest that miR-20b may have therapeutic value in combination with olaparib treatment for ovarian cancer.
lncRNA target	34092081	hsa-mir-150	Acute Lung Injury	However, the expression and significance of miR-150, AKT3 and SRPK1 in acute lung injury (ALI) were not clear. In conclusion, miR-150 and SRPK1 separately and cooperatively participate into inflammatory responses in ALI through regulating AKT3 pathway.
other	34092081	hsa-mir-150	Pneumonia	Increased miR-150 and silenced SRPK1 may be a novel potential factor for preventing and treating more inflammatory lung diseases.
transcription factor target	34092046	hsa-mir-93	Femur Head Necrosis	5p inhibitor could promote osteogenic differentiation by increasing BMP-2 expression during the development of TIONFH.
transcription factor target	34092046	hsa-mir-93	Wounds and Injuries	5p inhibitor could promote osteogenic differentiation by increasing BMP-2 expression during the development of TIONFH.
other	34091883	hsa-mir-223	Cardiovascular Diseases	In conclusion, a total of 45 miRs were associated with platelet function or maturity in patients with CVD, with miR-223 and miR-126 being the most frequently investigated.
other	34091883	hsa-mir-126	Cardiovascular Diseases	In conclusion, a total of 45 miRs were associated with platelet function or maturity in patients with CVD, with miR-223 and miR-126 being the most frequently investigated.
circRNA target	34091806	hsa-mir-27b	Lupus Nephritis	CircELK4 contributes to renal injury by promoting inflammation and cell apoptosis via acting as a miR-27b-3p sponge to modulate STING/IRF3/IFN-I signaling in LN.
lncRNA target	34091757	hsa-mir-26a	Diabetic Cardiomyopathies	CONCLUSION: Our study showed that GAS5 promotes DCM progression by regulating miR-26a/b-5p, suggesting that GAS5 might be a potential therapeutic target for DCM.
lncRNA target	34091757	hsa-mir-26b	Diabetic Cardiomyopathies	CONCLUSION: Our study showed that GAS5 promotes DCM progression by regulating miR-26a/b-5p, suggesting that GAS5 might be a potential therapeutic target for DCM.
genetics_overexpression_promote	34091587	hsa-mir-502	Pituitary Neoplasms	Mechanistically, overexpression of LINC00473 restricts miR3p through the ceRNA mechanism, upregulates KMT5A expression, and promotes the expression of cyclin D1 and CDK2, which is conducive to the cell cycle process, thereby promoting the proliferation of PA cells, involving IPA progression.
circulation_biomarker_diagnosis_ns	34091460	hsa-mir-221	psoriasis 1	3p was significantly increased in the serum of patients with psoriasis.
lncRNA target	34091391	hsa-mir-599	Colorectal Neoplasms	CONCLUSIONS: Circ_0084615 is a tumor-promoting circRNA in CRC that functions as a competing endogenous RNA to regulate DNMT3A expression via sponging miR-599.
lncRNA target	34091390	hsa-mir-650	Nasopharyngeal Carcinoma	CONCLUSION Our results demonstrated for the first time that miR-3650 was markedly upregulated in NPC tissues and positively associated with tumor progression and poor survival, suggesting that miR-3650 may be a potential novel prognostic biomarker and therapeutic target for NPC patients.
lncRNA target	34091117	hsa-mir-155	Encephalomyelitis, Autoimmune, Experimental	In conclusion, the alleviation of EAE by EA is characterized by reduced proportions of Th1/Th17 cells and increased proportions of Th2 cells, POMC upregulation, and miR-155 downregulation, while miR-155 itself can suppress POMC expression.
genetics_GWAS	34090498	hsa-mir-125b	Nerve Degeneration	Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR
genetics_GWAS	34090498	hsa-mir-24	Nerve Degeneration	Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR
genetics_GWAS	34090498	hsa-mir-21	Nerve Degeneration	Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR
genetics_GWAS	34090498	hsa-mir-199a	Nerve Degeneration	Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR
lncRNA target	34090492	hsa-mir-375	Stomach Neoplasms	mediated inhibition on GC cell stemness.
lncRNA target	34090483	hsa-mir-107	Gallbladder Neoplasms	Functionally, lncRNA TTN-AS1 promoted cell viability and motility in GBC by sponging miR-107.
lncRNA target	34090463	hsa-mir-335	Ovarian Neoplasms	CONCLUSION: XIST might be a carcinogenic lncRNA in ovarian cancer by regulating miR-335, and it can serve as a therapeutic target in human ovarian cancer.
lncRNA target	34090440	hsa-mir-744	Adenocarcinoma of Lung	5p inhibitor reversed the inhibitory effects of silencing LINC01116 on LAD malignant behaviors.
lncRNA target	34090323	hsa-mir-33a	Carcinoma, Pancreatic Ductal	CONCLUSIONS: Taken together, these results suggest that miR-33a-5p exerted tumor suppressive effects on PDAC cells by targeting RAP2A, which might provide a new theoretical basis for the clinical treatment of PDAC.
genetics_GWAS	34090052	hsa-mir-1205	Carcinoma, Hepatocellular	AIM: To investigate the prophylactic efficacy of gut microbiota-based treatments on nonalcoholic steatohepatitis (NASH) management via modulation of Hippo signaling pathway-related genes (YAP1, LATS1 and NF2), and their epigenetic regulators (miR-1205 and lncRNA SRD5A3-AS1) retrieved from in-silico data analysis.
circulation_biomarker_diagnosis_ns	34089908	hsa-mir-21	Bone Diseases, Metabolic	In vitro studies showed that miR-21@PSA-NP could effectively realize the intracellular delivery of miR-21 with low toxicity, while in vivo results indicated that the miR-21@PSA-NP-DSS(6) prolonged blood circulation time, enhanced bone accumulation, and significantly improved the efficacy of miR
lncRNA target	34089702	hsa-mir-633	Glioma	CONCLUSION: Sevoflurane repressed glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis, suggesting a new insight into the application of sevoflurane in glioma therapy.
genetics_overexpression_promote	34089591	hsa-mir-429	Hypertension	Functionally, overexpression of miR-429 transgene in the renal medulla significantly improved pressure natriuretic response, enhanced urinary sodium excretion, and reduced sodium retention upon extra sodium loading, and consequently, attenuated the salt-sensitive hypertension in Dahl S rats.
genetics_overexpression_promote	34089582	hsa-mir-338	Esophageal Squamous Cell Carcinoma	5p overexpressing ESCC cells was sufficient to derepress ESCC cell invasion both in vitro and in vivo.
lncRNA target	34089461	hsa-mir-17	Acute Kidney Injury	MiR5p was sponged by PVT1, and its inhibition weakened the impact of PVT1 deficiency on LPS-mediated injury of HK-2 cells.
transcription factor target	34089425	hsa-mir-373	Breast Neoplasms	CONCLUSIONS: Our results prove that miRNA-373, as an oncomir, would be a vital biomarker for BC diagnosis and prognosis by targeting both VEGF and cyclin D1.
genetics_knock down_promote	34089293	hsa-mir-489	Inflammation	This study revealed that shikonin protected WI-38 cells against LPS-induced cell injury and inflammatory response by regulating the miR
transcription factor target	34089082	hsa-mir-6741	Acute Kidney Injury	Henceforth, this study represents and demonstrates an effective association between miR3p and kidney diseases, i.e., collapsing glomerulopathy, chronic kidney disease (CKD), acute kidney injury (AKI), and tubulointerstitial lesions susceptibility to SARS-COV-2 infection via in silico and in vitro exploration and recommended to have better insight.
circulation_biomarker_diagnosis_up	34088891	hsa-mir-21	Colorectal Neoplasms	5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors.
circulation_biomarker_diagnosis_ns	34088630	hsa-mir-199a	Hypertrophy, Left Ventricular	As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration.
circulation_biomarker_diagnosis_up	34088630	hsa-mir-451a	Hypertrophy, Left Ventricular	RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients.
circulation_biomarker_diagnosis_ns	34088630	hsa-mir-199a	Cardiomyopathy, Hypertrophic	As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration.
circulation_biomarker_diagnosis_up	34088630	hsa-mir-29a	Cardiomyopathy, Hypertrophic	RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients.
circulation_biomarker_diagnosis_up	34088630	hsa-mir-451a	Cardiomyopathy, Hypertrophic	RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients.
circulation_biomarker_diagnosis_up	34088630	hsa-mir-29a	Hypertrophy, Left Ventricular	RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients.
other	34088068	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	In this study, we have investigated CdCl(2)-induced NAFLD in rats involves activation of miR34a/SIRT1/FXR axis. In conclusion, CdCl(2) induced NAFLD by increasing the transcription of miR-34a which in turn downregulates SIRT1 at the translational level.
other	34088068	hsa-mir-4	Non-alcoholic Fatty Liver Disease	In this study, we have investigated CdCl(2)-induced NAFLD in rats involves activation of miR34a/SIRT1/FXR axis. In conclusion, CdCl(2) induced NAFLD by increasing the transcription of miR-34a which in turn downregulates SIRT1 at the translational level.
circulation_biomarker_prognosis_up	34087856	hsa-mir-367	Breast Neoplasms	Furthermore, the relation between miR-367 in serum and clinicopathologic features and prognosis of BC patients was accessed.miR-367 expression in serum of the BC group was evidently lower than that in the control group (all P < .001).
other	34087839	hsa-mir-21	Breast Neoplasms	CONCLUSION: In this study, meta-analysis and bioinformatics analysis were used to further explore the prognosis, mechanism, and related pathways of miRNA-21 in breast cancer.
lncRNA target	34087832	hsa-mir-126	Instent Restenosis	METHODS: The literatures on the miRNA-126 diagnosis of ISR in CHD patients were collected by searching on computer through China National Knowledge Infrastructure, Wanfang, China Biology Medicine disc, PubMed, EMBASE, Cochrane Library and Web of Science.
lncRNA target	34087825	hsa-mir-182	Stomach Neoplasms	Through bioinformatics analysis, we further discussed the mechanism of miRNA-182 in gastric cancer and the understanding of related pathways.
transcription factor target	34087588	hsa-mir-29	Fibrosis, Renal	Overall, the localized delivery of cBSA/miR-29 b via a host-guest supramolecular hydrogel represents a safe and effective intervention strategy to delay and reverse the progression of interstitial renal fibrosis.
lncRNA target	34087084	hsa-mir-21	Diabetic Nephropathies	5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR
genetics_knock down_suppress	34086605	hsa-mir-92a	Sveinsson Chorioretinal Atrophy	In summary, the data demonstrated that AA protected against BMECs damage and TJs loss through the inhibition of miR-92a-3p expression.
genetics_knock down_promote	34086603	hsa-mir-29c	Alzheimer Disease	Silencing miR-29c-3p in BM-MSCs reduced BM-MSC-EV therapeutic effect on AD, which was reversed after BACE1 knockdown.
other	34086555	hsa-mir-214	Uterine Cervical Neoplasms	However, miR-214 was also up-regulated in the LSIL group (p=0.0062).
circulation_biomarker_diagnosis_up	34086555	hsa-let-7a	Uterine Cervical Neoplasms	However, miR-let-7a was higher in HPV positive plasma samples (p=0.0433) than in HPV negative plasma samples, and the correlation analysis confirmed the association between the levels of this miRNA with the presence of HPV (p=0.0407; r=0.3029), but not with lesion grade (p>0.05).
other	34086555	hsa-mir-21	Uterine Cervical Neoplasms	However, miR-214 was also up-regulated in the LSIL group (p=0.0062).
other	34086554	hsa-mir-21	Endometrial Neoplasms	CONCLUSION: Our findings support the important role of miR-21 as a biomarker to diagnose endometrial cancer.
genetics_knock down_promote	34086253	hsa-mir-141	Colonic Neoplasms	Knockdown of Bcl2 significantly enhanced the inhibition effect of miR
lncRNA target	34086111	hsa-mir-101	Stomach Neoplasms	CONCLUSION: In summary, our results indicated that LINC00943 was correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR3p.
genetics_overexpression_promote	34085707	hsa-mir-143	Colorectal Neoplasms	3p interacted with the 3' untranslated region (3'UTR) of FZD4 in CRC cells, and FZD4 overexpression partly reversed miR
circulation_biomarker_diagnosis_up	34085585	hsa-mir-155	Immune System Diseases	5p in the plasma of the Ginkgo biloba intervention group, the indicators in the serum reflecting arsenic-induced skin damage (Krt1, Krt6c, and Krt10) and the epithelial-mesenchymal transformation (EMT) vimentin were significantly reduced (P < 0.05), but the levels of NF-AT1 and the indicators reflecting arsenic-induced immunological dysfunction (IL-2, IFN-gamma) and EMT (E-cadherin) in serum were significantly increased (P < 0.05).
exosome	34085193	hsa-mir-183	Urinary Bladder Neoplasms	Using quantitative real-time polymerase chain reaction; expression of exosomal microRNA (miR)
exosome	34085193	hsa-mir-96	Urinary Bladder Neoplasms	Using quantitative real-time polymerase chain reaction; expression of exosomal microRNA (miR)
circulation_biomarker_diagnosis_up	34085179	hsa-mir-296	Diabetes Mellitus, Type 2	3p was downregulated in UA-induced Min6 cells and the serum of type 2 diabetes patients, while PTEN was upregulated in UA-induced Min6 cells.
other	34085163	hsa-mir-561	Arthritis, Gouty	circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis.
other	34085163	hsa-mir-192	Arthritis, Gouty	circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis.
transcription factor target	34084915	hsa-mir-200a	Maternal Death	We found that maternal uterine involution after delivery may involve two miRNA-target gene pairs, i.e., miRNA-200a-ZEB1 and YAP1.
lncRNA target	34084908	hsa-mir-33	Cardiovascular Diseases	Our study suggests that antisense therapeutic targeting of microRNA-33 may be a potential biomarker for cardiovascular disease.
transcription factor target	34084747	hsa-mir-17	Colorectal Neoplasms	We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR
transcription factor target	34084747	hsa-mir-17	Liver Neoplasms	We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR
transcription factor target	34084747	hsa-mir-185	Colorectal Neoplasms	We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR
transcription factor target	34084747	hsa-mir-185	Liver Neoplasms	We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR
target gene	34084220	hsa-mir-224	Breast Neoplasms	Long non-coding RNA CASC9/microRNA-590-3p axis participates in lutein-mediated suppression of breast cancer cell proliferation.
lncRNA target	34084218	hsa-mir-186	Uterine Cervical Neoplasms	3p expression was downregulated in cervical cancer tissues and cells, and it negatively regulated MCM2 expression by directly targeting its 3' untranslated region in cervical cancer.
other	34083664	hsa-mir-122	Carcinoma, Hepatocellular	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-21	Carcinoma, Hepatocellular	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-21	Metabolic Associated Fatty Liver  Disease 	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-122	Metabolic Associated Fatty Liver  Disease 	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-34a	Carcinoma, Hepatocellular	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-34a	Metabolic Associated Fatty Liver  Disease 	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-103	Metabolic Associated Fatty Liver  Disease 	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083664	hsa-mir-103	Carcinoma, Hepatocellular	3p in MAFLD/NASH animals was reduced with PR-PFD.
other	34083573	hsa-let-7d	Cardiovascular Diseases	3p, miR-133b level were significantly elevated in SS compared to IS groups.
other	34083573	hsa-mir-140	Cardiovascular Diseases	3p, miR-133b level were significantly elevated in SS compared to IS groups.
other	34083573	hsa-mir-133b	Cardiovascular Diseases	3p, miR-133b level were significantly elevated in SS compared to IS groups.
other	34083573	hsa-mir-142	Cardiovascular Diseases	3p, miR-133b level were significantly elevated in SS compared to IS groups.
other	34083573	hsa-mir-199a	Cardiovascular Diseases	3p, miR-133b level were significantly elevated in SS compared to IS groups.
exosome	34082869	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	An exosomal RNA-seq analysis was conducted to predict regulatory exosomal miRNAs related to OSCC growth, which determined miR
lncRNA target	34082777	hsa-mir-1287	Breast Neoplasms	CONCLUSION: Circ_0001982 affected BC cells glycolysis, proliferation, migration, and invasion through miR
lncRNA target	34082774	hsa-let-7a	Adenomyosis	If components of the hippo-YAP1 axis were unphosphorylated, upregulated let-7a could not inhibit the proliferation of ADS JZ SMCs.
genetics_GWAS	34082667	hsa-mir-7641	Rhinitis, Allergic	Sequencing analysis indicated that three kinds of mutations existed in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process.
lncRNA target	34082653	hsa-mir-106a	Moebius syndrome 1	Collectively, these results revealed that miR-106a-5p inhibited the proliferative, migratory, and invasive ability of ESCs via directly binding to FOXC1, likely through the suppression of the PI3K and its downstream signaling pathway, which offered a potential and novel therapeutic strategy for EMS treatment.
other	34082653	hsa-mir-106a	Endometriosis	Emerging evidence has exhibited an obvious decreased expression of miR-106a-5p in the ectopic endometrial tissue of endometriosis (EMS) patients.
lncRNA target	34082648	hsa-mir-92a	Breast Neoplasms	In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells.
exosome	34082434	hsa-mir-382	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-223	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-198	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-28	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-150	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-20a	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-29	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
exosome	34082434	hsa-mir-125b	Acquired Immunodeficiency Syndrome	We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198).
transcription factor target	34082245	hsa-mir-770	Pulmonary Fibrosis	Targeting miR5p might provide a new therapeutic strategy to prevent the abnormal activation of pulmonary fibroblasts in silicosis.
lncRNA target	34082012	hsa-mir-148a	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Runx3-miR-148a-3p axis targeted YBX1 to modulate NSCLC progression.
lncRNA target	34082009	hsa-mir-503	Myocardial Reperfusion Injury	CONCLUSIONS: In summary, PART1 protected mitochondrial function via miR5p/BIRC5 pathway in MI/RI, which may provide the new theoretical basis for MI/RI treatment in the clinic.
lncRNA target	34081870	hsa-mir-150	Diabetic Retinopathy	The linc00174 deteriorates diabetic retinal microangiopathy via regulating miR5p/VEGFA pathway, indicating a novel therapeutic target for DR treatment.
other	34081843	hsa-mir-194	Stomach Neoplasms	In particular, they show increased miR-194 levels are a predictor of more favourable gastric cancer prognosis, at least in part due to miR-194 downregulating production of a key protein for cancer development: CCND1.
other	34081808	hsa-mir-195	Osteosarcoma	MicroRNA-195 (miR-195) was shown to be a suitable biomarker for osteosarcoma, and the present study describes a sensitive method of miR-195 identification by nuclease digestion in ELISA to detect and quantify the level of miR-195. This method identified miR-195 at a lower level and will help to diagnose earlier stages of osteosarcoma.
lncRNA target	34081797	hsa-mir-145	Adenocarcinoma of Lung	Other experiments indicated that upregulation of each of miRNA-125a-5p or miRNA-145 inhibited cell growth, induced apoptosis, and markedly decreased the IC(50) value of erlotinib in A549 lung cancer cells (p < 0.05). The results of our study indicate that the therapeutic delivery of miRNA-145 and miRNA-125a-5p to lung cancer may inhibit cell proliferation, trigger apoptosis, and sensitize lung cancer cells to EGFR-TKIs.
lncRNA target	34081797	hsa-mir-125a	Adenocarcinoma of Lung	Other experiments indicated that upregulation of each of miRNA-125a-5p or miRNA-145 inhibited cell growth, induced apoptosis, and markedly decreased the IC(50) value of erlotinib in A549 lung cancer cells (p < 0.05). The results of our study indicate that the therapeutic delivery of miRNA-145 and miRNA-125a-5p to lung cancer may inhibit cell proliferation, trigger apoptosis, and sensitize lung cancer cells to EGFR-TKIs.
lncRNA target	34081624	hsa-mir-22	Cardiomyopathies	3p/Ltb4r1 signaling pathway appears to aggravate myocardial injury following a MI, which suggested that this signaling may be a useful target for improved and more individualized treatments for MI.
lncRNA target	34081624	hsa-mir-22	Myocardial Infarction, Acute	3p/Ltb4r1 signaling pathway appears to aggravate myocardial injury following a MI, which suggested that this signaling may be a useful target for improved and more individualized treatments for MI.
lncRNA target	34081622	hsa-mir-335	Colorectal Neoplasms	Our findings indicate that the ZEB1-AS1-miR5p-APOC1 ceRNA regulatory network is significantly valuable for better prognosis of patients with CRC and as a new therapeutic target for the treatment of CRLM.
transcription factor target	34080953	hsa-mir-372	Epstein-Barr Virus Infections	Hsa-miR5p, as well as other differential expressed miRNA, might serve as potential targets in the therapy of various EBV associated diseases.
other	34080770	hsa-mir-486	Fluorosis, Dental	This study, thus, contributes significantly in revealing the mechanism of miR3p-mediated CyclinD1 upregulation in skeletal fluorosis and sheds new light on endemic fluorosis treatment.
genetics_knock down_promote	34080658	hsa-mir-181a	Colorectal Neoplasms	Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR181a5p to decrease ROCK2 expression. In conclusion, circNSUN2 promoted the progression of CRC by sponging miR181a5p to increase the expression of ROCK2.
other	34080652	hsa-mir-199a	Lung Neoplasms	The regulatory effect of miR199a5p on autophagy may provide novel insights for future multidrugresistant lung cancer chemotherapy.
transcription factor target	34080651	hsa-mir-483	Pulmonary Fibrosis	In conclusion, these data indicated that miR4835p inhibition ameliorated TGFbeta1induced EMT by targeting RhoGDI1 via the Rac1/PI3K/Akt signaling pathway in PF, suggesting a potential role of miR4835p in the prevention and treatment of PF.
genetics_knock down_promote	34080649	hsa-mir-29c	Parkinson Disease	In addition, circSAMD4A knockdown repressed phosphorylatedAMPK expression and increased mTOR expression in MPTP or MPP(+)induced PD models, the effects of which were reversed by a miR29c3p inhibitor.
lncRNA target	34080640	hsa-mir-130b	Diabetic Neuropathies	On the whole, these results suggest that miR130b activates the PI3K/Akt signaling pathway to exert protective effects against oxidative stress injury via the regulation of PTEN in rats with DE.
genetics_overexpression_promote	34080639	hsa-mir-491	Colorectal Neoplasms	Furthermore, LBX2AS1 overexpression could notably reverse the inhibitory effect of miR4915p on proliferation and invasion of colorectal cancer cells.
other	34080437	hsa-mir-6736	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6716	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6761	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-208a	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-125a	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-24	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6754	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-4747	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6778	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6740	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-125b-1	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6753	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-595	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6875	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6762	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6787	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-4435	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-22	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6131	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-6747	Alzheimer Disease	3p) were down-regulated in AD.
other	34080437	hsa-mir-646	Alzheimer Disease	3p) were down-regulated in AD.
circulation_biomarker_diagnosis_up	34080404	hsa-mir-425	Pneumonia	Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells.
circulation_biomarker_diagnosis_up	34080404	hsa-mir-155	Pneumonia	Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells.
circulation_biomarker_diagnosis_up	34080404	hsa-mir-3	Pneumonia	Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells.
lncRNA target	34080033	hsa-mir-335	Retinoblastoma	These data suggested that the long noncoding RNA SNHG20 may promote cell proliferation, migration and invasion in RB via the miR3355p/E2F3 axis.
genetics_overexpression_promote	34080031	hsa-mir-875	Carcinoma, Non-Small-Cell Lung	Notably, it was determined that special ATrich sequencebinding protein 2 (SATB2) was a direct target gene of miR875, and overexpression of miR875 largely abrogated the effects of HCG11 in NSCLC cells. In conclusion, HCG11 was shown to suppress the malignant properties of NSCLC cells by targeting a miR875/SATB2 axis, and may therefore be a promising target for the treatment of NSCLC.
genetics_overexpression_promote	34080029	hsa-mir-454	Uterine Cervical Neoplasms	In conclusion, the present study indicated that ILF3AS1 inhibited CC cell proliferation and migration, and promoted CC cell apoptosis by inhibiting epithelialmesenchymal transition, and ILF3AS1 overexpression partially reversed the inhibitory effect of miR4543p on PTEN expression.
lncRNA target	34080028	hsa-mir-181a	Myocardial Infarction	These results provided a novel mechanistic insight into the role of ANRIL in H/Rinjured cardiomyocytes and suggested that the ANRIL/miR181a/SIRT1 axis may be a therapeutic target for reducing MI/R injury.
lncRNA target	34080023	hsa-mir-204	Hepatoblastoma	In summary, TUG1 was upregulated in hepatoblastoma and suppressed miR2045p, thereby activating the downstream signalling pathway of JAK2/STAT3 to facilitate angiogenesis.
lncRNA target	34079820	hsa-mir-200b	Esophageal Diseases	Collectively, this study suggests that MMC inhibited esophageal fibrosis by regulating cell apoptosis and autophagy via downregulating lncRNA-ATB and upregulating miR-200b.
lncRNA target	34079762	hsa-mir-1258	Glioblastoma	Furthermore, restoration of E2F1 expression in GBM cells effectively rescued the tumor-suppressive effect of miR-1258.
circRNA target	34079759	hsa-mir-20	Glioblastoma	Collectively, our findings showed that the circHECTD1-miR5p-SLC2A1 regulatory pathway promoted the progression of GBM, suggesting that circHECTD1 may be a therapeutic target for GBM.
genetics_knock down_promote	34079594	hsa-mir-499a	Leukemia, Myeloid, Acute	Knockdown of miR-499a-5p suppressed AML cell proliferation and promoted AML cell apoptosis, but silencing PDCD4 abolished this effect.
lncRNA target	34079592	hsa-mir-214	Colorectal Neoplasms	Inhibition of miR
genetics_overexpression_suppress	34079591	hsa-mir-590	pancreatic adenocarcinoma	In addition, overexpression of miR
lncRNA target	34079084	hsa-mir-654	Breast Neoplasms	In conclusion, our findings reveal that Lnc-408 promotes BC invasion and metastasis via the Lnc-408/miR5p/LIMK1 axis, highlighting a novel promising target for the diagnosis and treatment of BC.
transcription factor target	34079082	hsa-mir-26b	Lung Neoplasms	In the present study, we revealed that GPC5 transcriptionally enhanced the expression of CTDSP1 (miR-26b host gene) via AhR-ARNT pathway, and such up-regulation of CTDSP1 intracellularly contributed to the inhibited proliferation of lung cancer cells. By uncovering the regulation network among GPC5, miR-26b, miR-26b host gene (CTDSP1), and target gene (PTK2), our findings demonstrated that GPC5 functioned as a tumor suppressor in human lung cancer.
transcription factor target	34078833	hsa-mir-205	Myocardial Reperfusion Injury	In conclusion, miR-205 might participate in the protective effect of remifentanil in rat myocardial I/R injury via regulation of PINK1, providing a potential target for amelioration of cardiovascular ischemic disease.
transcription factor target	34078799	hsa-mir-135	Myocardial Infarction	Overall, miR-135a promotes ISO-induced cardiac injury by inhibiting the TLR4 pathway.
transcription factor target	34078799	hsa-mir-135a	Myocardial Infarction	Overall, miR-135a promotes ISO-induced cardiac injury by inhibiting the TLR4 pathway.
lncRNA target	34078755	hsa-mir-4270	Nasopharyngeal Carcinoma	In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo.
lncRNA target	34078519	hsa-mir-877	Stomach Diseases	5p may be a potential therapeutic target for gastric mucosal injury caused by aspirin.
genetics_overexpression_promote	34078414	hsa-mir-200b	Ovarian Neoplasms	miR-200b-overexpressed macrophages-conditioned medium notably enhanced the cell viability and invasion of ovarian cancer cells.
transcription factor target	34078310	hsa-mir-15a	Stomach Neoplasms	CONCLUSIONS: Collectively, these results suggest that LINC_00355 promotes GC progression by up-regulating PHF19 through sponging miR-15a-5p.
transcription factor target	34078216	hsa-mir-409	Parkinson Disease	The current study demonstrated that the inhibition of miR
genetics_knock down_promote	34077824	hsa-mir-18a	Intracranial Hemorrhages	Conversely, miR-18a knockdown or RUNX1 overexpression just presented an improvement effect on ICH.
circRNA target	34077501	hsa-mir-182	Sepsis	Our data suggested that circ_0091702 sponged miR-182 to regulate PDE7A, thereby alleviating LPS-induced cell injury in sepsis.
other	34077450	hsa-mir-122	Diabetes Mellitus, Type 2	3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05).
other	34077450	hsa-mir-126	Diabetes Mellitus, Type 2	3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05).
other	34077450	hsa-mir-146a	Diabetes Mellitus, Type 2	3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05).
genetics_knock down_promote	34077306	hsa-mir-1298	Carcinoma, Non-Small-Cell Lung	Taken together, circ_0003028 knockdown could suppress NSCLC progression partly by regulating the miR
lncRNA target	34077295	hsa-mir-515	Glioma	In conclusion, this study corroborated the regulatory mechanism of SP1/ZFPM2-AS1/miR5p/SOD2 axis in glioma, indicating that targeting ZFPM2-AS1 might be an effective way to treat glioma.
lncRNA target	34077011	hsa-mir-505	Osteosarcoma	5p is raised significantly in the cancer tissues of osteosarcoma patients, and the inhibition of miR
lncRNA target	34077008	hsa-mir-223	Lymphoma, Large B-Cell, Diffuse	CONCLUSIONS: MiR-223 may suppress the proliferation and promote the apoptosis of DLBCL c.
genetics_overexpression_promote	34077004	hsa-mir-326	Ovarian Neoplasms	MiR-326 overexpression markedly restrained the proliferation and invasion of OC cells, whereas miR-326 inhibitors exerted the contrary effect.
genetics_overexpression_promote	34077002	hsa-mir-326	Colorectal Neoplasms	RESULTS: miR-326 overexpression significantly inhibited the viability, invasion and migration and promoted the apoptosis of CRC cells, but overexpression of both E2F1 and miR-326 in turn increased cell viability, invasion and migration and decreased cell apoptosis.
circulation_biomarker_diagnosis_ns	34076996	hsa-mir-614	Stomach Neoplasms	PURPOSE: To investigate the expression of miR-614 in serum of gastric cancer patients and its effect on invasion and proliferation of gastric cancer cell line HGC-27. CONCLUSION: In conclusion, miR-614 is lowly expressed in gastric cancer patients and inhibits the invasion and proliferation of gastric cancer cell line HGC-27.
circulation_biomarker_prognosis_up	34076989	hsa-mir-203	Carcinoma, Hepatocellular	CONCLUSIONS: Serum level of miRNA-203 is downregulated in HCC patients, which is upregulated following TACE.
genetics_overexpression_promote	34076988	hsa-mir-497	Carcinoma, Hepatocellular	CONCLUSION: miR-497 was lowly expressed in HCC tissues, and its overexpression inhibited invasion and metastasis in HCC cells by suppressing VEGF-B levels.
other	34076987	hsa-mir-182	Carcinoma, Hepatocellular	5p were markedly downregulated in LIHC tissues.
lncRNA target	34076987	hsa-mir-22	Carcinoma, Hepatocellular	3p suppresses proliferative ability and arrests cell cycle progression in HCC through targeting CDKN2C.
genetics_overexpression_suppress	34076980	hsa-mir-188	Glioma	Overexpression of miRNA
lncRNA target	34076978	hsa-mir-335	Carcinoma, Non-Small-Cell Lung	PURPOSE: The purpose of this study was to illustrate the role of long non-coding RNA (lncRNA) NEAT1 in inhibiting sorafenib sensitivity in non-small cell lung cancer (NSCLC) through targeting microRNA-335 (miR-335)/c-Met axis. CONCLUSIONS: LncRNA NEAT1 aggravates sorafenib resistance in NSCLC through inhibiting MiR-335 to upregulate c-Met level, manifesting as attenuated proliferation and accelerated apoptosis.
other	34076850	hsa-mir-17	End Stage Liver Disease	Levels of miR-17 were remarkably higher in recipients with alcoholic ESLD.
other	34076840	hsa-mir-27a	Sepsis	Our results suggested that Linc-KIAA1737-2 could promote LPS-induced apoptosis in HK-2 cells, and presumably sepsis-induced acute kidney injury, by regulating the miR-27a-3p/TLR4/NF-kappaB axis.
other	34076840	hsa-mir-27a	Acute Kidney Injury	Our results suggested that Linc-KIAA1737-2 could promote LPS-induced apoptosis in HK-2 cells, and presumably sepsis-induced acute kidney injury, by regulating the miR-27a-3p/TLR4/NF-kappaB axis.
transcription factor target	34076811	hsa-mir-181b	Sepsis	This present study suggests that miR-181b decreased inflammatory factors and reduced myocardial injury in sepsis through downregulation of HMGB1.
transcription factor target	34076811	hsa-mir-181b	Myocardial Infarction	This present study suggests that miR-181b decreased inflammatory factors and reduced myocardial injury in sepsis through downregulation of HMGB1.
circulation_biomarker_diagnosis_ns	34076790	hsa-mir-150	Carcinoma, Endometrioid	We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients.
other	34076790	hsa-mir-27a	Carcinoma, Endometrioid	miRNA 27a was significantly associated with type I endometroid endometrial cancer.
epigenetics	34076365	hsa-mir-93	Osteoarthritis	RESULTS: Circ_HECW2 and miR-93 were inversely correlated, with Circ_HECW2 upregulated and miR-93 downregulated in OA and LPS-induced chondrocytes. CONCLUSION: In summary, our data revealed that the Circ_HECW2 is highly expressed in OA and might inhibit miR-93 expression through methylation to affect LPS-induced chondrocyte apoptosis.
genetics_knock down_promote	34076278	hsa-mir-184	Stomach Neoplasms	Also, FOSB knockdown offset the suppressive impact of miR-184 silencing on GC cell malignancy.
lncRNA target	34076140	hsa-mir-92b	Carcinoma, Hepatocellular	Furthermore, we confirmed by western blotting and immunofluorescence that miR-92b can mediate sorafenib resistance by activating the PI3K/AKT/mTOR pathway in HCC cells by directly targeting PTEN.
genetics_knock down_suppress	34075147	hsa-mir-148a	Breast Neoplasms	Here, we performed a knockdown of miR-148a using anti-miRNA oligonucleotides (AMOs) and investigated the effect on BC cell proliferation.
lncRNA target	34075120	hsa-mir-155	Autoimmune Diseases	MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4(+) T helper cells which are key players in autoimmune diseases. Small molecules that can modulate miR-155 may potentially provide new therapeutic avenues to inhibit Th17 cell-mediated autoimmune diseases.
other	34075120	hsa-mir-155	Dermatitis, Atopic	In addition, we found that FDA approved antiparasitic agents belonging to the 'azole' family also down-regulate Mir155 reporter and cytokine expression in Th17 cells, and thus could potentially be repurposed to treat Th17-driven immunopathologies.
transcription factor target	34075026	hsa-mir-5000	Colorectal Neoplasms	Moreover, through in vitro and in vivo experiments, miR
circulation_biomarker_diagnosis_ns	34074816	hsa-mir-127	Acquired Immunodeficiency Syndrome	5p to motor function, miRNAs previously identified in CSF or plasma in Alzheimer's and Parkinson's, respectively.
circulation_biomarker_diagnosis_ns	34074816	hsa-mir-485	Acquired Immunodeficiency Syndrome	5p to motor function, miRNAs previously identified in CSF or plasma in Alzheimer's and Parkinson's, respectively.
circulation_biomarker_diagnosis_up	34074322	hsa-mir-1	Adenocarcinoma of Lung	Furthermore, higher levels of circulating exosomal miR
lncRNA target	34073426	hsa-mir-146a	Colonic Neoplasms	A qRT-PCR validation step was conducted in a COAD patient cohort comprising of 29 tumor tissues and 29 normal adjacent tissues, endorsing the expression level for BMP5, as well as for two of the miRNAs targeting key EMT related genes, revealing upregulation of miR-27a-5p and miR-146a-5p.
lncRNA target	34073426	hsa-mir-27a	Colonic Neoplasms	A qRT-PCR validation step was conducted in a COAD patient cohort comprising of 29 tumor tissues and 29 normal adjacent tissues, endorsing the expression level for BMP5, as well as for two of the miRNAs targeting key EMT related genes, revealing upregulation of miR-27a-5p and miR-146a-5p.
other	34073154	hsa-mir-126	Prediabetic State	3p could potentially contribute to diabetes risk screening strategies.
other	34073090	hsa-mir-106a	Osteoarthritis	In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated.
other	34073090	hsa-mir-424	Osteoarthritis	In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated.
other	34073090	hsa-mir-365a	Osteoarthritis	In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated.
transcription factor target	34073090	hsa-mir-365a	Neoplasms, Second Primary	miR-365a-5p is known to directly target HDAC and NF-kB, and a decrease in HDAC activity by NMRT was detected.
other	34073090	hsa-mir-27a	Osteoarthritis	In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated.
other	34073090	hsa-mir-34b	Osteoarthritis	In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated.
lncRNA target	34072442	hsa-mir-34a	Triple Negative Breast Neoplasms	Our data form a solid foundation for promoting the use of a miR-34a-based approach to improve the therapeutic efficacy of selinexor in TNBC patients.
other	34071966	hsa-mir-122	Liver Diseases	miR5p can be used as a characteristic miRNA of UAB and may help to improve liver- and brain-related diseases.
other	34071966	hsa-mir-423	Muscular Diseases	Further analysis revealed that miR-423 can be used as a characteristic miRNA of UVB and has the potential to treat muscle-related diseases.
lncRNA target	34071861	hsa-mir-200c	Ovarian Neoplasms, High-Grade Serous	We identified the upregulation of miR-200c-3p expression in different stages of HGSC clinical samples and the downregulation of the tumor suppressor gene, Deleted in Liver Cancer 1 (DLC1), expression.
lncRNA target	34071707	hsa-mir-122	Cardiomyopathies	The downmodulation of cardiac Cx43, Cx26 and miR-122, high pS368-Cx43 phosphorylation, cell viability and survival activation could represent some of the female adaptative/compensatory reactions to ponatinib cardiotoxicity.
lncRNA target	34071592	hsa-mir-361	Pulmonary Disease, Chronic Obstructive	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-106b	Lung Neoplasms	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-497	Pulmonary Disease, Chronic Obstructive	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-497	Lung Neoplasms	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-361	Lung Neoplasms	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-27a	Lung Neoplasms	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-27a	Pulmonary Disease, Chronic Obstructive	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
lncRNA target	34071592	hsa-mir-106b	Pulmonary Disease, Chronic Obstructive	5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR
exosome	34071504	hsa-mir-643	Carcinoma, Hepatocellular	The present study was designed to identify the role of miR-643, which is one of the most significantly increased miRNA in exosomes released from cisplatin-resistant Heptocarcinoma cells, in altering the cisplatin resistance properties of recipient cells.
other	34071189	hsa-mir-126	Diabetes Mellitus, Type 2	MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus. To conclude, miR-126 expression is a strong and independent predictor of long-term all-cause mortality among patients with T2DM.
other	34070923	hsa-mir-106b	Colorectal Neoplasms	Thus, miR-106b/NR2F2-AS1/PLEKHO2/MAPK signaling axis may suggest the potential usage in CRC treatment.
lncRNA target	34070538	hsa-mir-139	Breast Neoplasms	mediated suppression of CXCR4/p-Akt signaling and thereby affected mesenchymal stem-cell genesis, indicating its potential as a therapeutic target for invasive breast cancer.
lncRNA target	34070455	hsa-mir-491	Chondrosarcoma	5p, and also Bcl-xL as a direct target of both miR
circulation_biomarker_diagnosis_ns	34070163	hsa-mir-1270	Pre-Eclampsia	Hsa-miR-1270 showed significantly different levels in cord blood EPC from preeclampsia versus control and was negatively correlated with mRNA levels of its predicted targets ANGPTL7 and TFRC.
circulation_biomarker_prognosis_ns	34069692	hsa-mir-16	Liver Cirrhosis	Our results emphasized that exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192, miR-146, and miR-16 are promising diagnostic and prognostic markers for both HCC and liver cirrhosis patients.
circulation_biomarker_prognosis_ns	34069692	hsa-mir-16	Carcinoma, Hepatocellular	Our results emphasized that exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192, miR-146, and miR-16 are promising diagnostic and prognostic markers for both HCC and liver cirrhosis patients.
other	34069135	hsa-mir-205	Breast Neoplasms	5p are expressed and released by BC cells, endothelial cells and during their interaction.
other	34069135	hsa-mir-194	Triple Negative Breast Neoplasms	5p are expressed and released by BC cells, endothelial cells and during their interaction.
other	34069135	hsa-mir-194	Breast Neoplasms	5p are expressed and released by BC cells, endothelial cells and during their interaction.
other	34069135	hsa-mir-205	Triple Negative Breast Neoplasms	5p are expressed and released by BC cells, endothelial cells and during their interaction.
target gene	34069116	hsa-mir-122	Carcinoma, Hepatocellular	Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122.
circulation_biomarker_diagnosis_up	34069089	hsa-mir-615	Breast Neoplasms	3p in the serum of patients with BC.
other	34069007	hsa-mir-181a	pancreatic adenocarcinoma	In situ hybridization of miR-181a and immunohistochemistry of EPB41L4B and SEL1L in pancreatic tissues (n = 4 Healthy; n = 3 IPMN; n = 4 PDAC) were also carried out.
other	34069007	hsa-mir-181a	Carcinoma, Pancreatic Ductal	In situ hybridization of miR-181a and immunohistochemistry of EPB41L4B and SEL1L in pancreatic tissues (n = 4 Healthy; n = 3 IPMN; n = 4 PDAC) were also carried out.
transcription factor target	34068941	hsa-mir-27b	Fibrosis, Renal	In conclusion, we suggest that selective inhibition of K63-Ub, when combined with the conventional treatment with ACE inhibitors, might represent a novel treatment strategy to prevent the progression of fibrosis and proteinuria in diabetic nephropathy and we propose miR-27b-3p as a biomarker of treatment efficacy.
transcription factor target	34068941	hsa-mir-27b	Diabetes Mellitus, Type 2	In conclusion, we suggest that selective inhibition of K63-Ub, when combined with the conventional treatment with ACE inhibitors, might represent a novel treatment strategy to prevent the progression of fibrosis and proteinuria in diabetic nephropathy and we propose miR-27b-3p as a biomarker of treatment efficacy.
other	34068397	hsa-mir-1228	Uterine Cervical Neoplasms	5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A.
other	34068397	hsa-mir-33a	Uterine Cervical Neoplasms	5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A.
other	34068397	hsa-mir-146a	Uterine Cervical Neoplasms	5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A.
other	34068397	hsa-mir-3200	Uterine Cervical Neoplasms	5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A.
other	34068397	hsa-mir-6815	Uterine Cervical Neoplasms	5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A.
genetics_GWAS	34068078	hsa-mir-15a	Leukemia, Myeloid, Acute	MiR-15a-5p overexpression in AML cells reduced apoptosis induced by both drugs in vitro.
other	34067956	hsa-mir-6782	Testicular Germ Cell Tumor	RT-qPCR validated hsa-miR5p to be present at 2.3-fold lower levels (p = 0.02) in the SP from men with TGCTs compared with controls.
circulation_biomarker_diagnosis_up	34067683	hsa-mir-421	Diabetes Mellitus, Type 2	Among them, miR-421 level was found to be decreased in the serum of diabetic patients, regardless of the presence or absence of diabetic complications, as well as being differential in various body mass index (BMI) groups.
other	34067335	hsa-mir-6798	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6780b	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-679	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6879	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6780b	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6798	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6879	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6126	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-679	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-711	Pancreatic Intraductal Neoplasms	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-711	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
other	34067335	hsa-mir-6126	Pancreatic Carcinoma	5p) in IPMC were significantly enriched compared to those in IPMA.
transcription factor target	34067060	hsa-mir-200c	Myocardial Infarction	Interestingly, we also found a significant upregulation of Follistatin-related protein 1 (FSTL1), a miR-200c predicted target already identified as a potent cardiogenic factor produced by epicardial cells that promotes regeneration following MI.
genetics_GWAS	34066331	hsa-mir-125b	Colonic Neoplasms	In conclusion, our data show that miR-125b-5p has an anti-cancer effect only in TP53 mutated colon cancer cells, explaining partially the dual behavior of this microRNA in malignant pathologies.
other	34063883	hsa-mir-378a	Diabetes Mellitus	These alterations correlated with a decrease in ATGL and Pgc1b expression in the OB group and with an increase of miR-378a-3p levels in the OBD group.
other	34063883	hsa-mir-378a	Obesity	These alterations correlated with a decrease in ATGL and Pgc1b expression in the OB group and with an increase of miR-378a-3p levels in the OBD group.
other	34063878	hsa-mir-125b-2	Glaucoma, Open-Angle	3p, and the miR-27a-3p.
other	34063878	hsa-mir-224	Ocular Hypertension	3p, and the miR-27a-3p.
other	34063878	hsa-mir-151a	Glaucoma, Open-Angle	3p, and the miR-27a-3p.
other	34063878	hsa-mir-151a	Ocular Hypertension	3p, and the miR-27a-3p.
other	34063878	hsa-mir-1307	Ocular Hypertension	3p, and the miR-27a-3p.
other	34063878	hsa-mir-224	Glaucoma, Open-Angle	3p, and the miR-27a-3p.
other	34063878	hsa-mir-27a	Ocular Hypertension	3p, and the miR-27a-3p.
other	34063878	hsa-mir-1307	Glaucoma, Open-Angle	3p, and the miR-27a-3p.
other	34063878	hsa-mir-125b-2	Ocular Hypertension	3p, and the miR-27a-3p.
other	34063878	hsa-mir-27a	Glaucoma, Open-Angle	3p, and the miR-27a-3p.
other	34063705	hsa-mir-141	Colorectal Neoplasms	In our study, the detection and expression of miR-141 in a cohort of colorectal cancer (n = 6) and breast cancer (n = 4) samples showed that its levels were significantly higher than in a healthy cohort (n = 9) (p < 0.004).
other	34063705	hsa-mir-141	Bulimia Nervosa	In light of this, we aimed to develop a high-sensitivity microRNA (miR) biosensor for application in the diagnosis of all miRassociated cancers, such as colorectal cancer (CRC) and breast cancer (BC).
other	34063705	hsa-mir-141	Breast Neoplasms	In our study, the detection and expression of miR-141 in a cohort of colorectal cancer (n = 6) and breast cancer (n = 4) samples showed that its levels were significantly higher than in a healthy cohort (n = 9) (p < 0.004).
genetics_overexpression_promote	34063443	hsa-mir-129	Melanoma	5p acts as a tumor suppressor as its overexpression decreased cell proliferation, improved treatment response and reduced viability of BRAFi resistant melanoma cells.
circulation_biomarker_diagnosis_ns	34063140	hsa-mir-148b	Glomerulonephritis, IGA	Serum levels of miR-148b, let-7b, and galactose-deficient IgA1 (Gd-IgA1) at the time of diagnosis were measured using real-time quantitative PCR and enzyme-linked immunosorbent assay using the monoclonal antibody KM55, respectively.
circulation_biomarker_diagnosis_ns	34063140	hsa-mir-148	Glomerulonephritis, IGA	Serum levels of miR-148b, let-7b, and galactose-deficient IgA1 (Gd-IgA1) at the time of diagnosis were measured using real-time quantitative PCR and enzyme-linked immunosorbent assay using the monoclonal antibody KM55, respectively.
other	34063140	hsa-let-7b	Glomerulonephritis, IGA	Patients with fast progression of the renal damage had significantly increased levels of let-7b (p = 0.01), Model 1 (p = 0.003), and Model 2 (p = 0.005) compared to slow progressors, as did those who reached ESKD (p = 0.002, p = 0.001, and p = 0.001, respectively).
other	34062414	hsa-mir-605	Complex Regional Pain Syndromes	We hypothesized that downregulation of miR-605 in poor responders to ketamine could increase CXCL5 expression and thereby contribute to inflammation in these patients. Thus, our studies suggest that miR-605 regulation of CXCL5 can regulate inflammation.
circulation_biomarker_diagnosis_ns	34062189	hsa-mir-20a	limb ischemia	The expression of MALAT1 and miR-320a was correlated with the changes of morphological and blood indices in obese children, and their correlations with endothelial dysfunction markers were obtained.
circulation_biomarker_diagnosis_ns	34062189	hsa-mir-20a	Obesity	The expression of MALAT1 and miR-320a was correlated with the changes of morphological and blood indices in obese children, and their correlations with endothelial dysfunction markers were obtained.
circulation_biomarker_diagnosis_ns	34062187	hsa-mir-19a	Glioblastoma	METHODS: Here we compared the expression of EGFR, miR-34a, and miR-19a between tumoral and adjacent non-cancerous tissues (ANCTs) of 50 GBM patients and also compared their expression levels in serum samples of GBM patients with serum samples of 50 control subjects.
circulation_biomarker_diagnosis_down	34062187	hsa-mir-34a	Glioblastoma	CONCLUSIONS: Dysregulation of the EGFR gene and miR-34a in serum samples of GBM patients compared with the control subjects promises the emergence of non-invasive biomarkers for early detection of GBM which need confirmative studies with a large sample size.
lncRNA target	34062164	hsa-mir-211	Depression	5p within the DG area in CUMS rats promoted neuronal neurogenesis, reduced neuronal apoptosis via suppression of the Dyrk1A/STAT3 signaling pathway and relieved depression-like behaviors in these CUMS rats.
lncRNA target	34062049	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	miR-9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC.
genetics_overexpression_suppress	34062009	hsa-mir-506	Triple Negative Breast Neoplasms	The results confirmed that overexpression of miR-506 and PENK in vivo through loading on GNs inhibited in situ triple-negative breast tumor growth and metastasis significantly in the xenograft model.
genetics_overexpression_suppress	34061466	hsa-mir-106a	Adenocarcinoma of Lung	To verify the relationship between SGMS1-AS1, miR-106a-5p, and MYLIP, we overexpressed miR-106a-5p inhibitor or MYLIP in LUAD cells after decreasing SGMS1-AS1 and repeated the above assays.
lncRNA target	34061447	hsa-mir-103a	Arthritis, Rheumatoid	CONCLUSION: Our data suggested that the linc00152/NF-kappaB feedback loop promotes RAFLS inflammation via regulating miR-103a/TAK1 axis and YY1 expression.
genetics_overexpression_suppress	34061329	hsa-mir-620	Breast Neoplasms	MiR-620 inhibitor hindered BC cell progression, which was similar to the effect of circ_0001666 overexpression. CONCLUSION: Circ_0001666 hindered the progression of BC via miR-620/WNK2 axis.
other	34061272	hsa-mir-383	Glomerulonephritis, IGA	miR-383 level was decreased in IgAN samples compared to healthy subject. In addition, miR-383 expression was also lower in urinary of IgAN cases than in urinary of healthy control.
transcription factor target	34061013	hsa-mir-28	Triple Negative Breast Neoplasms	OBJECTIVE: Using MDA-MB-231 cells as a model system for TNBC, we hypothesized that DHT would induce cell sensitivity towards doxorubicin via increasing levels of miR
genetics_GWAS	34060972	hsa-mir-146a	Arthritis, Rheumatoid	CONCLUSIONS: In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk.
tissue_expression_ns	34060486	hsa-mir-181b-1	Virus Diseases	miR-181ab1 deficiency in peripheral murine T cells causes delayed viral clearance after infection, resembling human immune aging.
tissue_expression_ns	34060486	hsa-mir-181a-1	Virus Diseases	miR-181ab1 deficiency in peripheral murine T cells causes delayed viral clearance after infection, resembling human immune aging.
lncRNA target	34060486	hsa-mir-181a	Virus Diseases	In conclusion, SIRT1 inhibition may be beneficial to treat systemic viral infection in older individuals by targeting antigen-specific T cells that develop replication stress due to miR-181a deficiency.
lncRNA target	34060415	hsa-mir-520g	Osteosarcoma	Moreover, the silence of circ_0102049 could markedly promote the proliferation, invasion, migration and cell-cycle promotion while inhibiting the apoptosis of OS cell line MG63 cells in vitro through regulating miR-520g-3p/PLK2 axis.
genetics_knock down_suppress	34060267	hsa-mir-140	Myocardial Reperfusion Injury	All in all, NEAT1 knockdown contributed to Sev-mediated myocardial I/R injury alleviation via the miR-140/RhoA axis.
lncRNA target	34059758	hsa-mir-182	Spinal Cord Injuries	Taken together, these data indicate that miR-182 improved SCI-induced secondary injury through inhibiting apoptosis and the inflammatory response by blocking the IKKbeta/NF-kappaB pathway.
circulation_biomarker_diagnosis_down	34059576	hsa-mir-502	Osteoporotic Fractures	3p were down-regulated in serum of patients with OPF, both of which could be used as potential biomarkers for the diagnosis and disease evaluation of OPF.
other	34058990	hsa-mir-29b	Osteoarthritis	The circHYBID-hsa-miR-29b-3p-TGF-beta1 axis may play a powerful regulatory role in HA metabolism and OA progression.
other	34058789	hsa-mir-96	Adenocarcinoma	In conclusion, this study sheds the light on M./P53/miR215/CD44 with an emphasis on M./miR96//foxO1 signaling cascades, as a novel pathway of melatonin signaling in adenocarcinoma to diminish cancer cell growth, survival and metastasis.
other	34058789	hsa-mir-215	Adenocarcinoma	In conclusion, this study sheds the light on M./P53/miR215/CD44 with an emphasis on M./miR96//foxO1 signaling cascades, as a novel pathway of melatonin signaling in adenocarcinoma to diminish cancer cell growth, survival and metastasis.
transcription factor target	34058620	hsa-mir-1271	Myocardial Infarction, Acute	miR5p decreased cardiomyocyte apoptosis induced by hypoxia and alleviated cardiac injury in AMI via down-regulating SOX6 expression.
transcription factor target	34058620	hsa-mir-1271	Heart Injuries	miR5p decreased cardiomyocyte apoptosis induced by hypoxia and alleviated cardiac injury in AMI via down-regulating SOX6 expression.
other	34058504	hsa-mir-129	Prostatic Hyperplasia	The findings led to the conclusion that the determination of miRNA-129 and VEGF can significantly contribute to the diagnosis of prostate disorders in dogs.
lncRNA target	34058384	hsa-mir-613	Carcinoma, Renal Cell	lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1
lncRNA target	34058384	hsa-mir-206	Carcinoma, Renal Cell	lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1
lncRNA target	34058384	hsa-mir-1-1	Carcinoma, Renal Cell	lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1
circulation_biomarker_diagnosis_ns	34058227	hsa-mir-451	Ischemic Stroke	By screening biomarkers in the peripheral blood of ischemic stroke patients, miR-451 was identified as a differentially expressed miRNA along the disease course of ischemic stroke.
circulation_biomarker_prognosis_up	34058065	hsa-mir-363	Breast Neoplasms	Our study revealed, for the first time, plasma exosomal miR
genetics_GWAS	34057989	hsa-mir-29	Chordoma	Somatic copy number gains of miR-29 loci in chordoma highlighted a mechanism of inactivation of TGFB3 signaling in tumor formation.
circRNA target	34057019	hsa-mir-936	Glioma	Additionally, miR-936 inhibited the glioma development via targeting ERBB4.
genetics_overexpression_promote	34057012	hsa-mir-2053	Esophageal Squamous Cell Carcinoma	After cell transfection, the effects of miR-2053 overexpression on proliferation, apoptosis, migration and invasion of esophageal cancer cells were determined.
genetics_overexpression_promote	34056735	hsa-mir-34a	Urinary Bladder Neoplasms	MiR-34a overexpression blocked bladder cancer cell migration and invasion, and induced cell apoptosis and cycle arrest, while these effects were abolished by CCND3 overexpression.
target gene	34056322	hsa-mir-7	Ovarian Neoplasms	Liposomal Delivery of MicroRNA-7 Targeting EGFR to Inhibit the Growth, Invasion, and Migration of Ovarian Cancer.
lncRNA target	34056113	hsa-mir-326	Pancreatic Carcinoma	CONCLUSION: circ_0066147 regulated PC malignant progression in part depending on the miR-326/E2F2 axis, illuminating circ_0066147 was a potential prognostic marker and therapeutic target for PC management.
lncRNA target	34056112	hsa-mir-136	Melanoma	5p suppressed melanoma progression by targeting RAB9A.
genetics_overexpression_promote	34056002	hsa-mir-603	Carcinoma, Hepatocellular	FABP1 overexpression reduced ROS in HCC cells, while miR-603 can reverse these effects.
genetics_overexpression_promote	34055989	hsa-mir-126	Carcinoma, Non-Small-Cell Lung	We also found that overexpression of ADAM9 could reverse the effects of miR
lncRNA target	34055978	hsa-mir-377	Colonic Neoplasms	Additionally, after downregulating NEAT1 in CCCs, transfection of NEAT1 siRNA packed with CNPs brought a great inhibition on cell proliferation and a promotion on apoptosis, and inhibiting miR
epigenetics	34055974	hsa-mir-142	Carcinoma, Hepatocellular	Finally, we found that miR-142 may be the important regulator for m(6)A RNA methylation in HCC.
genetics_overexpression_promote	34055896	hsa-mir-1251	Pancreatic Carcinoma	The oncogenic effects of circ_0001666 on EMT and PC cell invasion were rescued by miR-1251 overexpression. CONCLUSIONS: These results suggested that circ_0001666 acts as an oncogenic circRNA to promote EMT and invasion of PC cells through sponging miR-1251, and indicated that circ_0001666 could be explored as a potential therapeutic target for PC.
other	34055841	hsa-mir-448	Carcinoma, Hepatocellular	Conclusion: The newly identified PITPNA-AS/miR-448/ROCK1 axis promoted the oncogenicity of HCC cells.
genetics_overexpression_promote	34055778	hsa-mir-1290	Myocardial Infarction	Furthermore, in vivo animal studies showed that exosomes from EPCs with miR-1246 or miR-1290 overexpression attenuated the MI-induced cardiac injury in the rats and caused an increase in ELF5, SP1, and CD31 expression, respectively, but suppressed alpha-SMA expression in the cardiac tissues.
exosome	34055778	hsa-mir-1246	Myocardial Infarction	In conclusion, our study revealed that miR-1246 and miR-1290 in EPC-derived exosomes enhanced in vitro and in vivo angiogenesis in MI, and these improvements may be associated with amelioration of cardiac injury and cardiac fibrosis after MI.
other	34055770	hsa-mir-193	Placenta Diseases	Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases.
exosome	34055767	hsa-mir-9	Nerve Degeneration	Thus, our data indicate that NSC-derived exosomes facilitate the differentiation of NSCs via transferring miR-9, which sheds light on the development of cell-free therapeutic strategies for treating neurodegeneration.
other	34055638	hsa-mir-105	Breast Neoplasms	Conclusion In the present research, we identified 3 RNAs (hsa-miR5p, BCAR1 and PANX2) might associated with prognosis and metastasis of breast cancer, which might be provide a new perspective for metastasis of breast cancer and contributed to the treatment of breast cancer.
other	34055628	hsa-mir-493	Urinary Bladder Neoplasms	Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer as a sponge of miR-493-5p
genetics_GWAS	34055578	hsa-mir-342	Chromosome Aberrations	The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors, remains unclear.
other	34055578	hsa-mir-342	Cervical Intraepithelial Neoplasia	We first characterized the levels of miR-342 and ANXA2 in 31 cases of normal endometrium from patients with grade II-III cervical intraepithelial neoplasia or patients with hysterectomy versus ectopic endometrial tissues of 42 patients with endometriosis.
genetics_GWAS	34055578	hsa-mir-342	Endometriosis	The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors, remains unclear.
circulation_biomarker_diagnosis_up	34055487	hsa-mir-93	Prostatic Neoplasms	5p) in peripheral serum which could act as a non-invasive biomarker helping diagnosing PC.
other	34055120	hsa-mir-155	Low Back Pain	In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores.
other	34055120	hsa-mir-124a	Low Back Pain	In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores.
other	34055120	hsa-mir-558	Low Back Pain	In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores.
other	34055120	hsa-mir-146a	Low Back Pain	In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores.
lncRNA target	34055094	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	5p/ITGA2 signalling pathway might be an attractive target for future therapeutic options in NSCLC.
genetics_knock down_promote	34055079	hsa-mir-3677	Carcinoma, Hepatocellular	5p was indicated to significantly promote the proliferation, migration and invasion of HCC cells, whereas knockdown of miR
target gene	34055067	hsa-mir-1297	Prostatic Neoplasms	Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway.
target gene	34055060	hsa-mir-489	Psoriasis	miR-489-3p inhibits TLR4/NF-κB signaling to prevent inflammation in psoriasis.
other	34055058	hsa-mir-184	Thyroid Neoplasms	Thymosin β10 mediates the effects of microRNA-184 in the proliferation and epithelial-mesenchymal transition of BCPAP cells.
lncRNA target	34054958	hsa-mir-942	Stomach Neoplasms	More importantly, breast cancer metastasis suppressor 1 (BRMS1) inhibited GC progression by upregulating lncRNA HCG11 and downregulating miR
other	34054957	hsa-mir-25	Colorectal Neoplasms	CONCLUSION: Our results indicated that MSC-AS1 facilitated CRC progression by sponging miR-325 to upregulate TRIM14 expression.
other	34054947	hsa-mir-122	Diabetes Mellitus	At present, there are few reports concerning the relationship between miR-122 and diabetes. The present study aimed to investigate the role and modulatory mechanisms involving miR-122 in diabetes.
other	34054723	hsa-mir-103a	Infertility	Finally, we used the candidate miRNAs, miR-103a-3p and miR-10a-5p, to further investigate the relationship between their expression in FF and the outcomes of infertile patients undergoing IVF-ET treatment. Moreover, in another cohort of 106 infertile women undergoing IVF-ET treatment, miR-103a-3p or miR-10a-5p expression predicted the developmental status of the corresponding oocytes in which high expression of miR-103a-3p or miR-10a-5p resulted in a poor quality of embryo on days 3 and 5 during the IVF-ET treatment.
other	34054723	hsa-mir-10a	Infertility	Finally, we used the candidate miRNAs, miR-103a-3p and miR-10a-5p, to further investigate the relationship between their expression in FF and the outcomes of infertile patients undergoing IVF-ET treatment. Moreover, in another cohort of 106 infertile women undergoing IVF-ET treatment, miR-103a-3p or miR-10a-5p expression predicted the developmental status of the corresponding oocytes in which high expression of miR-103a-3p or miR-10a-5p resulted in a poor quality of embryo on days 3 and 5 during the IVF-ET treatment.
target gene	34054537	hsa-mir-578	Carcinoma, Non-Small-Cell Lung	CircRNA circ_0006677 Inhibits the Progression and Glycolysis in Non-Small-Cell Lung Cancer by Sponging miR-578 and Regulating SOCS2 Expression.
lncRNA target	34054430	hsa-mir-93	Spinal Cord Injuries	These findings suggest that the GAS5/miR-93/PTEN axis may be a promising therapeutic target for SCI.
lncRNA target	34054299	hsa-mir-17	Chordoma	CONCLUSION: Our results revealed the potential oncogenic effect of the miR-17/93 on chordoma progression, and suggested that the miR-17/93-p21 axis served as a promising therapeutic target in chordoma.
lncRNA target	34053876	hsa-mir-628	Carcinoma, Hepatocellular	CONCLUSIONS: ILF3-AS1 promoted hepatocellular carcinoma progression via the Notch pathway and miR
genetics_knock down_promote	34053467	hsa-mir-122	Uterine Cervical Neoplasms	5p in self-renewal and differentiation ability of CC stem cells were determined using ectopic expression, knockdown/depletion and reporter assay experiments.
circulation_biomarker_diagnosis_up	34053079	hsa-mir-1246	Mycosis Fungoides	Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls.
circulation_biomarker_diagnosis_up	34053079	hsa-mir-155	Mycosis Fungoides	Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls.
circulation_biomarker_diagnosis_up	34053079	hsa-mir-155	Plaque, Atherosclerotic	Plasma levels of cfmiR-1246 were significantly highest in combined plaque/tumour MF, followed by patch MF, and were lowest in controls (plaque/tumour > patch > healthy), while cfmiR-155 was upregulated only in plaque/tumour MF vs. Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls.
circulation_biomarker_diagnosis_up	34053079	hsa-mir-1246	Plaque, Atherosclerotic	Plasma levels of cfmiR-1246 were significantly highest in combined plaque/tumour MF, followed by patch MF, and were lowest in controls (plaque/tumour > patch > healthy), while cfmiR-155 was upregulated only in plaque/tumour MF vs. Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls.
exosome	34052997	hsa-mir-146a	Thrombocytopenia	In conclusion, these findings demonstrate that BMSC-derived exosomal miR-146a-5p regulates Th17/Treg imbalance in ITP by repressing IRAK1 expression. Thus, this work suggests that BMSCs-exosomal miR-146a-5p may be a potential therapeutic target for ITP.
genetics_overexpression_promote	34052838	hsa-mir-194	Brain Ischemia	Overexpression of circ_0000296 by miR
exosome	34052737	hsa-mir-361	Osteoarthritis	Overall, hBMSC-derived exosomal miR
other	34052462	hsa-mir-149	Osteoarthritis	METHODS: An initial database search led to the identification of miR5p, which was downregulated in clinical OA samples and contributed to chronic inflammation, by increasing TNF-alpha/IL-6 signaling within the synovium, and OA progression.
lncRNA target	34052320	hsa-mir-941	Homozygous Familial Hypercholesterolemia	Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR
lncRNA target	34052320	hsa-mir-941	Atherosclerosis	Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR
lncRNA target	34052320	hsa-mir-486	Atherosclerosis	Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR
lncRNA target	34052320	hsa-mir-486	Homozygous Familial Hypercholesterolemia	Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR
lncRNA target	34052307	hsa-mir-132	Lipid Metabolism Disorders	Taken together, our results revealed that lncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR3 P/SREBP1 signaling.
lncRNA target	34052307	hsa-mir-132	Prostatic Neoplasms	Taken together, our results revealed that lncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR3 P/SREBP1 signaling.
transcription factor target	34052187	hsa-mir-96	non-alcoholic steatohepatitis	Being a critical player in NASH development, caspase-2 targeting by miRNA5p could be a promising therapeutic modality to treat NASH.
lncRNA target	34051811	hsa-mir-520c	Cartilage Diseases	CONCLUSION: Our data showed that miR-520c-3p might regulate the GAS2 to inhibit the progression of OA.
other	34051810	hsa-mir-139	Ovarian Neoplasms	LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis.
lncRNA target	34051661	hsa-mir-128	Prostatic Neoplasms	Taken together, our data indicate that lncRNA OIP5-AS1 promotes PCa progression and ferroptosis resistance through miR
transcription factor target	34051305	hsa-mir-16	Diabetes Mellitus	These findings suggest that EGCG and quercetin exert synergistic anti-diabetes effect, possibly via decreasing the expression of miR5p that targets directly BCL-2.
genetics_knock down_promote	34051279	hsa-mir-24	Spinal Cord Injuries	5p alleviates the loss of animal locomotion and concurrently mediates several degenerative processes relevant to the pathogenesis of SCI by Sirt1, which may provide clues for SCI treatment.
transcription factor target	34051007	hsa-mir-4443	Thyroid Cancer, Papillary	We found that ectopic expression of miR-4443 inhibited PTC cell migration, invasion, ATP production, and aerobic glycolysis, while inhibition of miR-4443 had the opposite effect.
genetics_overexpression_promote	34050852	hsa-mir-21	Stomach Neoplasms	5p overexpression attenuated Lidocaine-induced anti-proliferative and anti-metastatic effects on GC cells.
genetics_knock down_promote	34050851	hsa-mir-619	Carcinoma, Non-Small-Cell Lung	Collectively, HOXA11-AS knockdown inhibited the progression of NSCLC by regulating miR
lncRNA target	34050453	hsa-mir-199a	Neuroblastoma	Overall, down-regulation of ID2-AS1 alleviated the neuronal injury in PD through regulating miR-199a-5p/IFNAR1/JAK2/STAT1 axis.
genetics_overexpression_promote	34050452	hsa-mir-653	Breast Neoplasms	HMGA2 overexpression abrogated the effect of miR
other	34050318	hsa-mir-143	Colorectal Neoplasms	Consistently, an inverse correlation between miR-143/miR-145 and CBFbeta expression levels is present in CRC patients.
other	34050318	hsa-mir-145	Colorectal Neoplasms	Consistently, an inverse correlation between miR-143/miR-145 and CBFbeta expression levels is present in CRC patients.
circulation_biomarker_diagnosis_down	34050266	hsa-mir-27a	Colorectal Neoplasms	Importantly, the expression levels of serum Linc00284 and miR-27a may serve as clinical biomarkers for CRC diagnosis.
genetics_overexpression_suppress	34050139	hsa-mir-518d	Carcinoma, Hepatocellular	In vitro and in vivo studies were performed in human hepatoma BCLC3 and Huh7 cells to analyze the effect of miR-518d-5p inhibition/overexpression during the response to sorafenib.
genetics_overexpression_promote	34050115	hsa-mir-148a	Glioblastoma	Cell invasion and migration analysis showed that overexpression of RP11-390F4.3 and ROCK1 resulted in increased, and overexpression of miR-148a resulted in deceased invasion and migration rates of glioblastoma cells.
genetics_knock down_promote	34050113	hsa-mir-338	Neuroblastoma	3p recovered the inhibitory effect of DANCR knockdown on neuroblastoma progression.
circulation_biomarker_prognosis_ns	34050091	hsa-mir-137	Intracranial Arteriosclerosis	In conclusions, our findings indicate that serum miR-137 levels are decreased in patients with cerebral AS and may be a new biomarker for diagnosing cerebral AS and predicting cerebrovascular events.
circulation_biomarker_prognosis_ns	34050091	hsa-mir-137	Cerebrovascular Disorders	In conclusions, our findings indicate that serum miR-137 levels are decreased in patients with cerebral AS and may be a new biomarker for diagnosing cerebral AS and predicting cerebrovascular events.
transcription factor target	34048990	hsa-mir-340	Urinary Bladder Neoplasms	Here, we proved that propofol regulated miR-340/CDK2 axis to suppress bladder cancer progression in vitro. CONCLUSION: In total, our results proved that targeting miR340/CDK2 axis was novel to enhance the anti-tumor effects of propofol in bladder cancer in vitro, and our study provided alternative therapeutic strategies for clinical treatment of bladder cancer.
transcription factor target	34048989	hsa-mir-155	Hypoxia	DEX, via down-regulating the expression of miR-155, could activate the ERK1/2 pathway, thereby mitigating the apoptosis and oxidative stress injury and increasing the MMP, thereby protecting hippocampal cells from OGD/R injury.
other	34048924	hsa-mir-23a	Uterine Cervical Neoplasms	Furthermore, some XIST-associated axes, namely XIST | miR-23a-3p | LGR4 and XIST | miR-30b-5p or miR-30c-5p or miR-30e-5p I ADAM9, had a significant impact on the overall survival of HPV16- and HPV18-CESC patients, respectively.
genetics_knock down_promote	34048784	hsa-mir-141	Keloid	LINC01116 knockdown or miR-3141 overexpression suppressed keloid fibroblast proliferation, migration, and promoted cell apoptosis.
transcription factor target	34048646	hsa-mir-155	Inflammation	Therefore, sequential detection of inflammation-related miR-155 (by external modified hairpin DNAs) and the cancer target of monocarboxylate transporter 1 (MCT1) (by internal loaded pH-sensitive carbon dots and MCT1 inhibitor-AZD3965) are achieved.
lncRNA target	34048366	hsa-mir-340	Osteosarcoma	In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR5p and activating the PI3K/AKT signaling pathway.
genetics_overexpression_promote	34048322	hsa-mir-451	Glioma	We demonstrated that overexpression of miR-451 suppressed glioma cell proliferation, invasion, migration and EMT by MTT and colony formation assays, Transwell assays, wound healing assays and animal experiments.
genetics_overexpression_promote	34048311	hsa-let-7i	ankylosing spondylitis 1	Ankylosing spondylitis (AS) is a chronic autoimmune disease in which let-7i has been studied to involved. Low expression of let-7i-3p could enhance osteoblast differentiation in AS by up-regulating PDK1.Abbreviations: AS: Ankylosing spondylitis; PDK1: pyruvate dehydrogenase kinase 1; TNF-alpha: tumor necrosis factor-alpha MMP: matrix metalloproteinase; OPG: osteoprotegerin; RANKL: receptor activator of nuclear factor-kappaB ligand; miRNAs: MicroRNAs; BMD: bone mineral density; PFA: paraformaldehyde; NC: negative control; OE: overexpression; HE: Hematoxylin-eosin; PBS: phosphate-buffered saline; EDTA: ethylene diamine tetraacetic acid; DMEM: Dulbecco's Modified Eagle Medium; RT-qPCR: Reverse transcription quantitative polymerase chain reaction; GAPDH: glyceraldehyde phosphate dehydrogenase; UTR: untranslated region; WT: wild type; MUT: mutant type.
circulation_biomarker_diagnosis_up	34048187	hsa-mir-92a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	RESULTS: plasma miRNA 92a and miRNA 638 expressions were elevated in ALL cases at the time of diagnosis (2.51 and 2.19 folds), and relapsed (2.1 and 1.61 folds) than that of patients with remitted ALL.
circulation_biomarker_diagnosis_up	34048187	hsa-mir-638	Precursor Cell Lymphoblastic Leukemia-Lymphoma	RESULTS: plasma miRNA 92a and miRNA 638 expressions were elevated in ALL cases at the time of diagnosis (2.51 and 2.19 folds), and relapsed (2.1 and 1.61 folds) than that of patients with remitted ALL.
other	34048164	hsa-mir-145	Breast Neoplasms	5p could be potential biomarkers to distinguish breast cancer patients from healthy controls.
other	34048164	hsa-mir-22	Breast Neoplasms	5p could be potential biomarkers to distinguish breast cancer patients from healthy controls.
other	34048164	hsa-mir-27b	Breast Neoplasms	5p could be potential biomarkers to distinguish breast cancer patients from healthy controls.
other	34047878	hsa-mir-637	Glioblastoma	Presently, we observed the increased expression of ZEB2 and the decreased expression of miR-637 in GBM. The collective findings suggest that ZEB2 and WNT/beta-catenin cascades merge at miR-637, and the ectopic expression of miR-637 disturbs ZEB2/WNT/beta-catenin-mediated GBM growth.
other	34047479	hsa-mir-199a	Carcinoma, Hepatocellular	LINC01133 sponged miR-199a-5p, resulting in enhanced expression of SNAI1, which induced epithelial-to-mesenchymal transition (EMT) in HCC cells. CONCLUSIONS: LINC01133 promotes HCC progression by sponging miR-199a-5p and interacting with ANXA2.
circRNA target	34046939	hsa-mir-665	Uterine Cervical Neoplasms	Mechanistically, circMYBL2 could inhibit the PTX sensitivity and promote cell malignant behaviors in PTX-sensitive and PTX-resistant CC cells via upregulating EGFR mediated by miR-665. CircMYBL2 played a positive role in the PTX resistance and malignant activities of PTX-sensitive and PTX-resistant CC cells by regulating the miR-665/EGFR network, providing a novel therapeutic strategy for the treatment of CC patients resistant to PTX.
target gene	34046406	hsa-mir-182	Thyroid Neoplasms	Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9.
transcription factor target	34046357	hsa-mir-200	Colorectal Neoplasms	Our results suggest the involvement of partial EMT at invasive tumor front, and partial MET in metastases in CRC, based on miR-200 family and its target genes expression.
other	34046349	hsa-mir-21	Adenocarcinoma of Lung	Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP (human lung adenocarcinoma drug-resistant cell line) cells.
other	34046349	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP (human lung adenocarcinoma drug-resistant cell line) cells. Hence, reduction of the expression of miRNA-21 in combination with cisplatin chemotherapy may effectively improve the therapeutic effect on patients with non-small cell lung cancer, and this may provide a theoretical basis for the treatment of this disease.
other	34046191	hsa-mir-1915	Chorioamnionitis	5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.
other	34046191	hsa-mir-4535	Chorioamnionitis	5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.
lncRNA target	34045897	hsa-mir-520a	Nasopharyngeal Carcinoma	CONCLUSION: These results suggest that SNHG16 acts as an oncogene in the progression of NPC via modulating the miR-520a-3p/MAPK1 axis.
exosome	34045869	hsa-mir-31	Colonic Neoplasms	CONCLUSION: Circ-PI4KA attenuated SEV-treated colon cancer cell malignancy by upregulating LASP1 through binding to miR
other	34045679	hsa-mir-150	Sepsis	Taken together, our data show that XIST/miR5p/c-Fos axis affected septic myocardial injury, which may indicate a novel therapeutic strategy for sepsis-induced myocardial injury.
other	34045679	hsa-mir-150	Cardiomyopathies	Taken together, our data show that XIST/miR5p/c-Fos axis affected septic myocardial injury, which may indicate a novel therapeutic strategy for sepsis-induced myocardial injury.
lncRNA target	34045663	hsa-mir-28	Breast Neoplasms	3p is a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also a model for the miRNA-fatty acid beta-oxidation-stemness axis, which may assist inunderstanding the cancer stem cell signaling functions of miRNA.
genetics_overexpression_suppress	34045601	hsa-mir-9	Prostatic Neoplasms	Taken together, our results suggest that inhibiting the expression of the oncomiR miR5p and overexpressing NUMB may represent novel therapeutic strategies to target PCSCs and PCa metastasis.
lncRNA target	34045549	hsa-mir-26b	Pre-Eclampsia	The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia.
other	34045467	hsa-mir-200c	Breast Neoplasms	MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
lncRNA target	34045139	hsa-mir-204	Osteoarthritis	5p in regulating inflammatory responses of human osteoarthritic synovial fibroblasts (SFs).
lncRNA target	34044859	hsa-mir-449a	Lung Neoplasms	CONCLUSION: It is eventually concluded that miR-449a delays lung cancer development through suppressing KDM3A/HIF-1alpha axis.
other	34044826	hsa-mir-6734	Glioma	3p to facilitate glioma development, proposing LINC01158 as a new player in glioma.
circulation_biomarker_diagnosis_up	34044822	hsa-mir-1250	Lymphoma, Non-Hodgkin	METHODS: AATK/miR-1250 methylation was studied in healthy controls, including ten normal peripheral blood buffy coats and eleven normal tonsils, ten lymphoma cell lines, and 120 primary lymphoma samples by methylation-specific PCR (MSP).
transcription factor target	34044650	hsa-mir-564	Lupus Erythematosus, Systemic	RESULTS: Bioinformatics analysis showed that miR-564 was up-regulated in SLE patients, and TP53 was the core target gene of miR-564.
genetics_overexpression_promote	34044640	hsa-mir-572	Prostatic Neoplasms	Overexpression of miR-572 decreased sensitivity of PCa cells to docetaxel treatment by reducing docetaxel-induced apoptosis.
transcription factor target	34044364	hsa-mir-3074	Abortion, Spontaneous	5p expression in ESCs might cause early pregnancy failure by disturbing decidualization of ESCs via the miR
other	34043986	hsa-mir-133a	Cardiomyopathies	Therefore, interfering with circHelz/miR-133a-3p/NLRP3 axis might be a promising therapeutic approach for ischemic cardiac diseases.
other	34043986	hsa-mir-133a	Myocardial Infarction	Therefore, interfering with circHelz/miR-133a-3p/NLRP3 axis might be a promising therapeutic approach for ischemic cardiac diseases.
lncRNA target	34043929	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC.
lncRNA target	34043929	hsa-mir-210	Carcinoma, Non-Small-Cell Lung	The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC.
lncRNA target	34043929	hsa-mir-1290	Carcinoma, Non-Small-Cell Lung	The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC.
genetics_knock down_suppress	34043680	hsa-mir-377	Osteoporosis	Furthermore, the therapeutic effect of hsa_circ_0001275 knockdown on osteoporosis was notably reversed by miR-377 antagomir.
other	34043149	hsa-mir-130a	Breast Neoplasms	In addition, bioinformatic analyses indicated that LINC00963/hsa-mir-130a-3p/HSPA8 axis might have potential regulatory role in BC.
lncRNA target	34043125	hsa-mir-145	Prostatic Neoplasms	Our results suggested that miR-145 suppressed the motility of prostate cancer cells via post-transcriptional downregulation of CDH2 expression, and miR
other	34042547	hsa-mir-382	Myocardial Infarction, Acute	5p reduced apoptosis of myocardial cells after AMI and the effect was achieved by increasing STC1 expression.
other	34042291	hsa-mir-206	Cardiac Complexes	Using a full structural equitation modelling of the total study sample, we found that the higher the increase in MF was observed in patients, the higher the probability of a decrease in the expression of miR-206 and TRIM63 and the lower severity of cardiac comorbidities.
other	34042286	hsa-mir-128	Colitis	3p in IBD, experimental colitis animal model was generated by 2,4,6-Trinitrobenzenesulfonic acid solution (TNBS).
circulation_biomarker_diagnosis_up	34042273	hsa-mir-202	Alzheimer Disease	In summary, we showed novel data that downregulation of serum miR-202 may be used as a potential biomarker for AD and may promote the development of AD by targeting APP.
genetics_overexpression_suppress	34042256	hsa-mir-192	Uterine Cervical Neoplasms	Finally, we found that TRPM7 overexpression reversed the inhibitory effects of miR
genetics_overexpression_promote	34042220	hsa-mir-10396	Hypertrophy	Our results showed that overexpression of miR-10396b-3p suppresses MS-induced LFH by inhibiting collagen I and III via the inhibition of IL-11. These data suggest that the MS-miR-10396b-3p-IL-11 axis plays a key role in the pathological progression of LFH.
genetics_knock down_promote	34041718	hsa-mir-188	Osteosarcoma	This study revealed that HCG18 knockdown repressed the viability, invasion and migration of OS cells by targeting miR
transcription factor target	34041689	hsa-mir-9	Fahr's disease	Bioinformatics analysis predicts almost 100 ion channels, membrane transporters and receptors, including genes linked to primary familial brain calcification (PFBC), as possible miR5p targets.
transcription factor target	34041689	hsa-mir-9	Progressive Familial Heart Block, Type Ib	5p targets.
genetics_knock down_promote	34041646	hsa-mir-30	Respiratory Distress Syndrome	In short, circANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells in vitro via sponging miR-330, which may provide new ideas for the treatment of sepsis-induced ARDS.
genetics_knock down_promote	34041646	hsa-mir-30	Sepsis	In short, circANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells in vitro via sponging miR-330, which may provide new ideas for the treatment of sepsis-induced ARDS.
lncRNA target	34041621	hsa-mir-26	Triple Negative Breast Neoplasms	3p as prognostic and therapeutic targets that can be exploited to predict or prevent BM.
lncRNA target	34041621	hsa-mir-101	Triple Negative Breast Neoplasms	3p as prognostic and therapeutic targets that can be exploited to predict or prevent BM.
other	34041583	hsa-mir-92a	Pituitary Diseases	MicroRNA (miR)-92a in the inflammatory endothelial dysfunction leads to atherosclerosis.
other	34041583	hsa-mir-92a	Decompression Sickness	RESULTS: MiR-92a increased after balloon injury and was present in HCAEC culture media. Chrysin was treated, and significantly attenuated the miR-92a levels after balloon injury, and similar results were obtained in HCAEC cultures in vitro.
exosome	34041043	hsa-mir-92a	Acute Lung Injury	In conclusion, AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p in ALI. miR-92a-3p in AEC exosomes might represent a novel diagnostic biomarker for ALI, which may lead to a new therapeutic approach.
exosome	34041043	hsa-mir-92a	Sepsis	In conclusion, AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p in ALI. miR-92a-3p in AEC exosomes might represent a novel diagnostic biomarker for ALI, which may lead to a new therapeutic approach.
transcription factor target	34040893	hsa-mir-199a	Liver Cirrhosis	Notably, downregulation of miR-199a-5p decreased TGF-beta1-induced expression of fibrosis markers. CONCLUSIONS: DZNep suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 axis, suggesting that DZNep may represent a novel treatment for fibrosis.
genetics_overexpression_promote	34040437	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	5p inhibition and NFAT5 overexpression offset the suppressive impact of circ_0001944 silencing on proliferation, migration, invasion, and glycolysis of NSCLC cells.
circulation_biomarker_diagnosis_ns	34040409	hsa-mir-122	Metabolic Associated Fatty Liver  Disease 	OBJECTIVE: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD. CONCLUSION: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.
other	34040396	hsa-mir-21	Asthma	RESULTS: The expression of miR5p was upregulated in macrophages of rats in vivo with OVA-induced asthma.
genetics_knock down_promote	34040392	hsa-mir-215	Thyroid Cancer, Papillary	5p was a direct target of circWDR27, and its inhibition reversed the suppressive effect of circWDR27 knockdown on PTC cell progression.
target gene	34040389	hsa-mir-29b	Stomach Neoplasms	MicroRNA-29b-3p Inhibits the Migration and Invasion of Gastric Cancer Cells by Regulating the Autophagy-Associated Protein MAZ.
target gene	34040388	hsa-mir-545	Neuroblastoma	Long Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis.
other	34040387	hsa-mir-145	Cholangiocarcinoma	5p/MAL2 axis could enhance CHOL progression, which might be useful to improve the clinical outcomes of CHOL patients.
other	34040372	hsa-mir-21	Osteoporosis	CONCLUSION: We have described for the first time a new concept of osteoporosis treatment based on nHAp/IO@miR-21/124 application.
other	34040139	hsa-mir-148a	Adenocarcinoma of Lung	Then, six prognostic RNAs (FKBP3, GPI, LOXL2, IL22RA1, GPR37, and has-miR-148a-3p) were viewed as the key members for constructing the prognostic prediction model in the ceRNA network, and three kinds of TIICs (Monocytes, Macrophages M1, activated mast cells) were identified to be significantly related with the prognosis in lung adenocarcinoma.
other	34040057	hsa-mir-23b	Multiple Myeloma	Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a).
other	34040057	hsa-let-7b	Multiple Myeloma	Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a).
other	34040057	hsa-mir-20a	Multiple Myeloma	Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a).
other	34039992	hsa-mir-34a	Colorectal Neoplasms	To generate training data, colorectal cancer HCT116 cells were subjected to miR-34a treatment and then classified using a conventional Annexin V/propidium iodide (PI)-staining assay.
genetics_overexpression_promote	34039939	hsa-mir-16	Melanoma	Rescued experiments confirmed that SOX4 overexpression abolished the inhibition effect of miR-16 mimics on growth, metastasis and EMT process of melanoma.
genetics_knock down_promote	34039781	hsa-mir-34a	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	In conclusion, our results demonstrated that knockdown of miR-34a-5p in extracellular vesicles derived from T-ALL cells promoted osteogenic differentiation of BMSCs by regulating WNT1.
transcription factor target	34039371	hsa-mir-20a	Encephalomyelitis, Autoimmune, Experimental	miR-20a is dysregulated in patients with CNS inflammatory demyelinating diseases; however, the function of miR-20a remains unclear. miR-20a antagomirs alleviate EAE, suggesting a new therapy for EAE and CNS inflammatory demyelinating diseases.
lncRNA target	34039026	hsa-mir-181b	Leukemia, Lymphocytic, Chronic, B-Cell	Conclusion:CARD11 is a novel target of miR-181b that is upregulated, which could be a poor prognostic indicator for CLL patients.
other	34038763	hsa-mir-34b	Atherosclerosis	Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease.
other	34038763	hsa-mir-34c	Atherosclerosis	Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease.
other	34038612	hsa-mir-96	Carcinoma, Hepatocellular	Identification of microRNA-96-5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma.
lncRNA target	34038520	hsa-mir-206	Colorectal Neoplasms	Mechanistic studies (Bioinformatics binding site analyses, the Luciferase reporter, Ago2 immunoprecipitation, the RNA pull-down, immunofluorescence colocalization, rescued assays and western blotting) implicated that RP11-51O6.1 could regulate YAP1 expression by competitively sponging miR-206 and blocking its activity in promoting CRC progression. Conclusively, our findings identify a novel RP11-51O6.1/miR-206/YAP1 regulatory axis that participates in CRC progression and development, suggesting RP11-51O6.1 is an exploitable biomarker and appealing therapeutic target in treating CRC.
genetics_overexpression_promote	34038200	hsa-mir-99a	Squamous Cell Carcinoma of Head and Neck	Functional assays revealed that miR-99a-5p overexpression significantly inhibited the proliferation, migration, and invasion abilities of CAL-27 and TCA-8113 OSCC cells.
circulation_biomarker_diagnosis_up	34038062	hsa-mir-874	Pneumonia	3p was reduced in serum samples of pediatric patients with pneumonia, and LPS treatment dose-dependently decreased miR
other	34038061	hsa-mir-496	Adenocarcinoma of Lung	Mir-496 may be an independent prognostic factor in lung adenocarcinoma.
lncRNA target	34037971	hsa-mir-124	Myocardial Infarction	Silencing miR-124 could inhibit the inflammation and apoptosis of myocardial cells, thereby relieving the MI injury via upregulation of STAT3.
lncRNA target	34037903	hsa-mir-362	Reperfusion Injury, Cerebral Ischemia	In conclusion, depletion of XIST attenuated I/R-induced neurological impairment and inflammatory response via the miR-362/ROCK2 axis.
genetics_overexpression_suppress	34037470	hsa-mir-494	Acute Lung Injury	Overexpression of miR
lncRNA target	34037099	hsa-mir-182	Prostatic Neoplasms	Our study proved that miR-182 participated in the proliferation and invasion of PCa cells via mediating expression of ST6GALNAC5 and established a miR-182/ST6GALNAC5/PI3K/AKT axis in regulation of tumor progression.
lncRNA target	34037089	hsa-mir-515	Stomach Neoplasms	DLGAP1-AS1 promoted GC progression through miR5p/MARK4 signaling pathway.
genetics_overexpression_promote	34036868	hsa-mir-1253	Osteosarcoma	Overexpression of miR-1253 could significantly inhibit OS cell proliferation, migration, invasion and EMT.
lncRNA target	34036857	hsa-mir-7	Breast Neoplasms	Taken together, our data for the first time reveal the biological implication of circ-TPGS2 in BC, it triggers TME reshaping that facilitates BC metastasis through the miR-7/TRAF6/NF-kappaB signalling cascade.
circRNA target	34036483	hsa-mir-1233	Carcinoma, Renal Cell	Circ_RPL23A inhibited ccRCC progression by upregulating ACAT2 expression by competitively binding miR-1233, which might provide an in-depth cognition for ccRCC pathogenesis and circ_RPL23A might be a promising biomarker in ccRCC diagnosis and treatment.
genetics_overexpression_promote	34036397	hsa-mir-375	Tinnitus	Additionally, miR3753p overexpression via injection of miR3753p mimic reduced the proportion of animals with persistent tinnitus.
other	34036390	hsa-mir-421	Reperfusion Injury	Recent studies have demonstrated that microRNA421 (miR421) prevents inflammation in cerebellar ischemia reperfusion injury.
lncRNA target	34036390	hsa-mir-421	Acute Lung Injury	In conclusion, the present study demonstrated the protective effect of miR421 on ALI and showed that miR421 attenuates LPSinduced ALI by inhibiting PDCD4 and NFkappaB.
genetics_overexpression_suppress	34036386	hsa-mir-135a	Gallbladder Neoplasms	In addition, overexpression of miR135a5p significantly inhibited the proliferation and migration of GBCSD cells.
other	34036383	hsa-mir-411	Carcinoma, Pancreatic Ductal	In the present study, the expression of PCED1BAS1, microRNA (miR)4113p and hypoxia inducible factor (HIF)1alpha mRNA in 47 cases of PDAC tissues were detected using reverse transcriptionquantitative (RTq)PCR. In conclusion, PCED1BAS1 expression was upregulated in PDAC tissues and cells, and it participated in promoting the proliferation, invasion and EMT of cancer cells by modulating the miR4113p/HIF1alpha axis.
genetics_overexpression_promote	34036380	hsa-mir-153	Retinoblastoma	Functional analysis revealed that the overexpression of miR153 inhibited RB cell proliferation, migration and invasion, and promoted the apoptosis of WERIRB1 and Y79 cells.
lncRNA target	34036377	hsa-mir-145	Brain Injuries, Traumatic	In conclusion, propofol maintained Th17/Treg balance and reduced inflammation in the rats with TBI via the miR1453p/NFATc2/NFkappaB axis.
genetics_knock down_promote	34036176	hsa-mir-510	Colonic Neoplasms	Additionally, the upregulation of miR-510 significantly promoted cell proliferation, migration, and invasion of colon cancer, while its knockdown significantly inhibited these cellular processes.
genetics_overexpression_promote	34035993	hsa-mir-9	Spinal Cord Ischemia	In conclusion, overexpression of miR-9 improves neurological outcomes after SCII and might inhibit BSCB disruption, neuroinflammation, and apoptosis through MAP2K3-, or Notch2-mediated signaling pathway in SCII.
genetics_knock down_promote	34035852	hsa-mir-9	Carcinoma, Hepatocellular	3p knockdown enhanced the protein expression level of IGF1R in HCC cells compared with the corresponding control groups.
lncRNA target	34035851	hsa-mir-375	Carcinoma, Renal Cell	These results collectively revealed that LUCAT1 promoted the proliferation, migration and invasion of ccRCC by the upregulation of YAP1 via sponging miR-375, which may be used as a potential therapeutic target for ccRCC.
lncRNA target	34035814	hsa-mir-552	Stomach Neoplasms	In conclusion, miR-552 serves as a tumor promoter in GC through targeting FOXO1 and regulating EMT and PI3K/AKT pathway.
lncRNA target	34035482	hsa-mir-339	Ovarian Neoplasms	These results determined that MAFG-AS1 stimulated the OC malignant progression by upregulating the NFKB1-mediated IGF1 via miR5p, thus highlighting a novel potential therapeutic target against OC.
exosome	34035464	hsa-mir-19b	Fractures, Bone	Collectively, these results indicate that mesenchymal stem cell-derived exosomal miR-19b represses the expression of WWP1 or Smurf2 and elevates KLF5 expression through the Wnt/beta-catenin signaling pathway, thereby facilitating fracture healing.
transcription factor target	34035375	hsa-mir-101	Breast Neoplasms	A higher expression of miR5p predicted better prognosis in patients with HER2+breast cancer (OS: p=0.039; BCSS: p=0.012), supporting the tumor-suppressing role of this miRNA.
circRNA target	34035217	hsa-mir-431	Glioma	In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
lncRNA target	34034740	hsa-mir-639	Ovarian Neoplasms	CONCLUSIONS: circ-PTK2 is an important molecule in regulating the pathogenic processes of ovarian cancer via the miR-639 and FOXC1 regulatory cascade.
other	34034626	hsa-mir-133b	Uterine Cervical Neoplasms	LncRNA MST1P2 serves as a Cervical Cancer oncogene by sponging with miR-133b.
genetics_knock down_promote	34034499	hsa-mir-212	Stomach Neoplasms	3p knockdown, respectively.
genetics_knock down_promote	34034499	hsa-mir-132	Stomach Neoplasms	3p knockdown, respectively.
genetics_overexpression_suppress	34034455	hsa-mir-144	Adenocarcinoma of Lung	3p in lung adenocarcinoma cell A549 was significantly decreased (P<0.05), and the overexpressed plasmid was successfully transfected (P<0.05).
circulation_biomarker_diagnosis_ns	34034413	hsa-mir-1825	Breast Neoplasms	miR-1825 may become a potential serum marker for the diagnosis of breast cancer and monitoring of therapeutic efficacy.
transcription factor target	34033710	hsa-mir-204	Acute Lung Injury	Thus, targeting miR3p may be a potential therapeutic strategy for ALI.
genetics_overexpression_promote	34033197	hsa-mir-124	Squamous Cell Carcinoma of Head and Neck	3p overexpression showed opposite effects.
circRNA target	34032607	hsa-mir-502	Osteoarthritis	Thus, silencing of hsa_circ_0032131 inhibited the progression of OA by inactivating the miR5p/PRDX3/Trx1/STAT3 axis, which highlights its potential as a therapeutic target for OA.
transcription factor target	34032330	hsa-mir-214	Bone Diseases	Increased osteoblastic differentiation by an miR5p inhibitor reveals a new possible strategy for the treatment of bone defect and osteoporosis.
transcription factor target	34032330	hsa-mir-214	Osteoporosis	Increased osteoblastic differentiation by an miR5p inhibitor reveals a new possible strategy for the treatment of bone defect and osteoporosis.
lncRNA target	34032148	hsa-mir-515	Carcinoma, Non-Small-Cell Lung	Findings in our study support that SNHG3/miR5p/SUMO2 regulatory axis may become a potential therapeutic target for lung cancer.
lncRNA target	34031995	hsa-mir-23	Posterior Segment Ocular Diseases	Herein, antisense oligonucleotide-loaded CCMV nanoparticles, intended for intravitreal injection, are evaluated for selective silencing of miR-23, an important target in AMD.
circRNA target	34031947	hsa-mir-152	Triple Negative Breast Neoplasms	CONCLUSIONS: Hsa_circ_102229 might serve as a competing endogenous RNA (ceRNA) to modulate PFTK1 expression via regulating miR3p to affect the functions of TNBC cells.
circulation_biomarker_diagnosis_up	34031917	hsa-mir-122	Fatty Liver	OBJECTIVE: This study proposed to assess the use of hepatocyte-derived canine familiaris (cfa)-microRNAs (miRNA-122, -34a, and -21) as new diagnostic serum biomarkers of liver steatosis or fibrosis, for which both processes have been implicated in canine cholecystolithiasis. CONCLUSIONS: Serum cfa-miRNA-122, -34a, and -21 expression was significantly upregulated in dogs with cholecystolithiasis with hepatic steatosis or fibrosis compared with control dogs.
circulation_biomarker_diagnosis_up	34031917	hsa-mir-122	Cholecystolithiasis	OBJECTIVE: This study proposed to assess the use of hepatocyte-derived canine familiaris (cfa)-microRNAs (miRNA-122, -34a, and -21) as new diagnostic serum biomarkers of liver steatosis or fibrosis, for which both processes have been implicated in canine cholecystolithiasis. CONCLUSIONS: Serum cfa-miRNA-122, -34a, and -21 expression was significantly upregulated in dogs with cholecystolithiasis with hepatic steatosis or fibrosis compared with control dogs.
lncRNA target	34031369	hsa-mir-99b	Osteoarthritis	Further studies showed that MFG-E8 was inhibited by miR-99b-5p, expression of which was significantly upregulated in OA cartilage, leading to exacerbation of experimental OA partially through activation of NF-kappaB signaling in chondrocytes.
lncRNA target	34031216	hsa-mir-574	Uterine Cervical Neoplasms	In conclusion, the LINC00997/miR3p/CUL2 axis contributes to CC cell proliferation, migration, invasion, and autophagy via the activation of MAPK signaling.
circulation_biomarker_diagnosis_ns	34031204	hsa-mir-223	Charcot-Marie-Tooth Disease	In addition, the putative Schwann cell miRs (e.g., miR223, -199a, -328, -409, -431) correlate with the recently described transmembrane protease serine 5 (TMPRSS5) protein biomarker that is most highly expressed in Schwann cells and also elevated in CMT1A plasma.
lncRNA target	34030715	hsa-mir-542	Colorectal Neoplasms	3p/TRIB2 axis to inactivate of Wnt/beta-catenin pathway, which providing a novel target for CRC treatment.
lncRNA target	34030529	hsa-mir-31	Arthritis, Rheumatoid	In summary, this study demonstrated that FOXD2-AS1 promoted RA progression via regulating the miR
genetics_GWAS	34030497	hsa-mir-100	Prostatic Neoplasms	MiR100 was overexpressed in prostate cancer with worse prognostic factors.
genetics_knock down_suppress	34030482	hsa-mir-512	Ovarian Neoplasms	Furthermore, the knockdown of CHRAC1 inhibited proliferation, migration, and invasion, and accelerated apoptosis of DDP-resistant OC cells, which was counteracted after the inhibition of miR
other	34030477	hsa-mir-194	Sepsis	In conclusion, MIR155HG promotes sepsis progression in an in vitro sepsis model by modulating the miR5p/MEF2A axis.
circulation_biomarker_diagnosis_ns	34030095	hsa-mir-21	Pancreatic Carcinoma	Significant distinctions are seen in the frequency shifts for exosomal miR-21 quantitation in clinical plasma samples between pancreatic cancer patients and healthy controls.
lncRNA target	34029939	hsa-mir-199a	Carcinoma, Hepatocellular	These findings suggest that miR-199a-5p is a potential therapeutic target of HCC, and matrine may represent a promising anti-metastatic medication for HCC therapy.
other	34029828	hsa-mir-495	Breast Neoplasms	From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis.
other	34029828	hsa-mir-6501	Breast Neoplasms	From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis.
other	34029828	hsa-mir-937	Breast Neoplasms	From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis.
other	34029828	hsa-mir-592	Breast Neoplasms	From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis.
lncRNA target	34029007	hsa-mir-129-2	Epilepsy, Temporal Lobe	2-3p/GABRA1 pathway may represent a potential target for the prevention and treatment of refractory epilepsy.
other	34028994	hsa-mir-205	Diabetes Mellitus	CONCLUSION: MiR5p was identified as relevant microRNA involved in islet dysfunction by interacting with TCF7L2.
lncRNA target	34028890	hsa-mir-103a	Stomach Neoplasms	Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC.
lncRNA target	34028890	hsa-mir-107	Stomach Neoplasms	Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC.
lncRNA target	34028890	hsa-mir-593	Stomach Neoplasms	Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC.
exosome	34028833	hsa-mir-29c	Coronary Disease	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
exosome	34028833	hsa-mir-125b	Coronary Disease	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
exosome	34028833	hsa-mir-155	Coronary Disease	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
exosome	34028833	hsa-mir-125b	Nephritis, Interstitial	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
exosome	34028833	hsa-mir-155	Nephritis, Interstitial	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
exosome	34028833	hsa-mir-29c	Nephritis, Interstitial	EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group.
transcription factor target	34028661	hsa-mir-33a	Vascular Calcification	The aim of the present study was to investigate how miR-33a-5p regulated vascular calcification stimulated by ox-LDL. Taken together, these results suggest miR-33a-5p suppresses VSMCs calcification stimulated by ox-LDL via targeting METTL3, highlighting the critical role of miR-33a-5p/METTL3 in vascular calcification.
circRNA target	34027799	hsa-mir-145	Osteoporosis	In summary, these results demonstrated that the role of circ_0062582 in osteoporosis is mediated through regulating the expression level of CBFB via miR-145.
genetics_overexpression_suppress	34027766	hsa-mir-429	Acute Kidney Injury	Overexpression of miR-429 attenuated apoptosis and elevated cell viability in a CI-AKI cell model via targeting PDCD4 and thus restraining NF-kappaB signalling.
genetics_overexpression_promote	34027641	hsa-mir-193a	Ovarian Neoplasms	DNM3OS overexpression enhanced OC cell proliferation, migration, and invasion; suppressed E-cadherin protein expression; and facilitated N-cadherin protein expression, while the transfection of miR-193a-3p mimics had the opposite effects.
genetics_overexpression_suppress	34027135	hsa-mir-634	Thyroid Carcinoma, Anaplastic	Here, we found that the overexpression of miR-634 synergistically increased lenvatinib-induced cytotoxicity by concurrently downregulating multiple genes related to cytoprotective processes, including ASCT2, a glutamine transporter, in ATC cell lines.
other	34027086	hsa-mir-199a	Myocardial Infarction	Previous studies have demonstrated that microRNA (miR) 199a-3p protect against MI. These results demonstrate that MMNPs ameliorate left ventricular remodeling and cardiac functions, and protect against MI, suggesting MMNPs containing miR199a-3p is a potential therapeutic approach to treat MI.
lncRNA target	34026693	hsa-mir-223	Cardiovascular Diseases	These data also suggest that miR-223 expression may be used as a marker for KD vasculitis pathogenesis and provide a novel therapeutic target.
lncRNA target	34026693	hsa-mir-223	Mucocutaneous Lymph Node Syndrome	These data also suggest that miR-223 expression may be used as a marker for KD vasculitis pathogenesis and provide a novel therapeutic target.
target gene	34026654	hsa-mir-125b	Triple Negative Breast Neoplasms	LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer.
target gene	34026626	hsa-mir-194	Urinary Bladder Neoplasms	Long Noncoding RNA KCNMB2-AS1 Promotes SMAD5 by Targeting miR-3194-3p to Induce Bladder Cancer Progression.
other	34026620	hsa-let-7	Neuroblastoma	Using microRNA trapping by RNA affinity purification, we provide a comprehensive view of MYCN-regulatory miRNAs in neuroblastoma-derived cells, confirming a pivotal role of the miR92 cluster and moderate association by the let-7 miRNA family.
transcription factor target	34026326	hsa-mir-204	Alzheimer Disease	Silencing of miR-204 could upregulate TRPML1 expression, thus suppressing ROS production and mitochondrial autophagy in AD through STAT3 pathway.
lncRNA target	34026068	hsa-mir-23a	Liver Neoplasms	MAGI2-AS3 might be a potential therapeutic target for liver cancer owing to its regulation by the miRNA-23a-3p/PTEN axis.
genetics_GWAS	34025683	hsa-mir-129-1	Non-alcoholic Fatty Liver Disease	Some of the identified genetic loci are implicated in the pathological pathways of NAFLD, including the lanosterol synthase gene (LSS) associated with glutathione peroxidase activity (Gpx) levels, the mitochondrial pyruvate carrier-1 gene (MPC1) and the sphingolipid transporter-1 gene (SPNS1) associated with hemoglobin levels, the transforming growth factor-beta-induced gene (TGFBI) and the micro-RNA 129-1 (MIR129-1) associated with IL-6 and the granzyme B gene (GZMB) associated with IL-10 levels.
other	34025560	hsa-mir-23b	Huntington Disease	We found an HD-specific signature: downregulation of hsa-miR-98 (fold change, -1.5, p = 0.0338 HD vs. HS, and fold change, 1.5, p = 0.0045 HD vs. PP) and upregulation of hsa-miR-323b-3p (fold change, 1.5, p = 0.0007 HD vs. HS, and fold change, 1.5, p = 0.0111 HD vs. PP). We were able to confirm that hsa-miR-323b-3p was upregulated in HD and premanifest HD vs. HS and PP: the median values (first-third quartile) were 4.1 (0.9-10.53) and 5.8 (1.9-10.70) vs. 0.69 (0.3-2.75) and 1.4 (0.78-2.70), respectively, p < 0.05.
exosome	34024846	hsa-mir-125b	Diabetic Nephropathies	It has been suggested that miR-125b is involved in DN. However, the biological functions of exosomal miRNAs, especially miR-125b, in DN are still unclear.
other	34024830	hsa-mir-551a	Alzheimer Disease	RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers.
other	34024830	hsa-mir-206	Alzheimer Disease	RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers.
other	34024830	hsa-mir-133b	Alzheimer Disease	RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers.
genetics_overexpression_suppress	34024254	hsa-mir-93	Breast Neoplasms	Overexpression of miR
circRNA target	34024251	hsa-mir-628	Glioblastoma	CONCLUSION: Silencing hsa_circ_0006168 might suppress GBM proliferation and motility via serving as competitive endogenous RNA for miR
lncRNA target	34024242	hsa-mir-338	Carcinoma, Non-Small-Cell Lung	3p per se suppressed NSCLC in vitro and its downregulation diminished the tumour-suppressive role of circ_0010235 blockage in NSCLC cells.miR
target gene	34024225	hsa-mir-212	Cognition Disorders	5p showed a neuroprotective effect in isoflurane-induced cognitive dysfunction rats by inhibiting neuroinflammation.
other	34024202	hsa-mir-22	Venous Thrombosis	We therefore hypothesized that hsa_circRNA_000455/hsa-miR3p/NLRP3 may involve in the development of deep vein thrombosis.
other	34024195	hsa-mir-155	Lymphoma, Mantle-Cell	5p levels may be correlated with poor prognosis in MCL.
other	34024195	hsa-mir-34a	Lymphoma, Mantle-Cell	Identification of miRNA-34a and miRNA-155 as prognostic markers for mantle cell lymphoma.
genetics_overexpression_promote	34024178	hsa-mir-425	Uterine Cervical Neoplasms	Additionally, silencing of RAB2B could suppress the growth of cervical cancer cells but its overexpression could rescue the tumor-suppressive effects of miR-425.
exosome	34024119	hsa-mir-381	Spinal Cord Injuries	In this paper we report on the effects of MSC-EV-microRNA-381 (miR-381) in a rodent model of SCI.
genetics_overexpression_promote	34024034	hsa-mir-720	Glioma	Functional experiments showed that overexpression of miR-720 promotes glioma migration and invasion, while downregulation of miR-720 inhibits glioma migration and invasion.
transcription factor target	34024028	hsa-mir-183	Cerebral Hemorrhage	CONCLUSION: BMSC-EVs carried miR5p into db/db-ICH rat brain tissues and repressed the NLRP3 pathway by targeting PDCD4, thus alleviating neuroinflammation after diabetic ICH.
circRNA target	34024023	hsa-mir-612	Esophageal Squamous Cell Carcinoma	RESULTS: Circ_0006948 and LASP1 were increased, and miR-3612 was decreased in ESCC tissues and cells. CONCLUSION: Circ_0006948 boosted ESCC progression partly by regulating the miR-3612/LASP1 axis, providing an underlying therapeutic target for the ESCC treatment.
genetics_overexpression_promote	34023860	hsa-mir-200b	Prostatic Neoplasms	Moreover, mechanistic analysis revealed that PPARG2 overexpression induced increased expression level of miR-200b-3p, which targeted 3' UTR of the downstream targets DNMT3A/3B, and facilitated interaction with demethylated AKAP12 gene promoter and suppressed cell proliferation in PCA.
lncRNA target	34023817	hsa-mir-107	Carcinoma, Hepatocellular	In conclusion, our study demonstrated that FEZF1-AS1 promoted HCC progression through activating Wnt/beta-catenin signaling by targeting miR-107, which provided a novel target for the therapy of HCC.
target gene	34023560	hsa-mir-348	Breast Neoplasms	Hsa_circ_0092276 promotes doxorubicin resistance in breast cancer cells by regulating autophagy via miR-348/ATG7 axis.
genetics_knock down_promote	34023283	hsa-mir-543	Uterine Cervical Neoplasms	We also found that overexpression of miR-543 impeded proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells by targeting FNDC3B.
circRNA target	34022910	hsa-mir-194	Esophageal Squamous Cell Carcinoma	5p/JMJD1C axis, providing a promising therapeutic target for ESCC chemotherapy.
lncRNA target	34022794	hsa-mir-501	Endometrial Neoplasms	CONCLUSIONS: MiR-501, which functions as an oncomir in endometrial cancer, might be a potential therapeutic target in high grade endometrial cancer.
genetics_overexpression_promote	34022711	hsa-mir-16	Fibrosis, Skin	5p-overexpressing keratinocytes-derived exosomes significantly enhanced miR
lncRNA target	34022583	hsa-mir-148a	Ischemic Stroke	3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS.
lncRNA target	34022583	hsa-mir-19a	Ischemic Stroke	3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS.
lncRNA target	34022583	hsa-mir-342	Ischemic Stroke	3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS.
circulation_biomarker_diagnosis_up	34022359	hsa-mir-155	Echinococcosis	The results also revealed that miR-146a and miR-155 upregulation in the plasma leads to the development of novel biomarkers for echinococcosis.
exosome	34022068	hsa-mir-942	Colorectal Neoplasms	CONCLUSION: Our data revealed that exosomal circEPB41L2 sponged miR
genetics_overexpression_promote	34021861	hsa-mir-4306	Esophageal Squamous Cell Carcinoma	Furthermore, we explored the molecular mechanism of effects of miR-4306 and found that miR-4306 inhibited the expression of SIX3 by interaction with SIX3 3'UTR in ESCC cells, and SIX3 overexpression significantly reversed the effect of miR
genetics_knock down_suppress	34021822	hsa-mir-646	Carcinoma, Hepatocellular	Further, FZD4 was a target of miR-646, and its overexpression could invert the inhibition effect of miR-646 mimic on HCC progression.
lncRNA target	34021567	hsa-mir-195	Incontinentia Pigmenti	Circ_0038467 silencing protected MRC-5 cells from LPS-induced injury by miR5p/TLR4 axis through NF-kappaB pathway, providing a theoretical basis for circRNA-directed IP therapy.
genetics_overexpression_promote	34021445	hsa-mir-9	Mouth Neoplasms	We have investigated the overexpression of miR
circRNA target	34021307	hsa-mir-527	Urinary Bladder Neoplasms	Lastly, circ_0001495 was found to promote the proliferation, migration and invasion of BCa cells in vitro through the miR-527/Robo1 axis and promote the growth and metastasis of BCa tumors in vivo. Altogether, findings in our study highlight the promoting role of circ_0001495 in the progression of BCa by increasing Robo1 via sponging miR-527, representing a promising target for BCa management.
lncRNA target	34021273	hsa-mir-34b	Colonic Neoplasms	Collectively, miR-34b-5p targets HuR and miR-34b-5p binds to OIP5-AS1 with HuR, thus inhibiting OIP5-AS1 and PI3K/Akt pathway and CC progression.
transcription factor target	34021255	hsa-mir-625	Urinary Bladder Neoplasms	RBM24-regulated BC cell proliferation was moderated via the Runx1t1/TCF4/miR
genetics_knock down_promote	34021124	hsa-mir-187	Pituitary Neoplasms	TUG1 knockdown inhibited cell proliferation, invasion, migration, and epithelial-mesenchymal transition, promoted apoptosis, and regulated the expression of NF-kappaB p65 and inhibitor of kappaB (IkappaB)-alpha in PA cells lines in vitro, and also inhibited tumor growth in vivo, and these effects were reversed by miR
lncRNA target	34020639	hsa-mir-488	Squamous Cell Carcinoma of Head and Neck	MiR-488 was a target of circ_0000745, and circ_0000745 downregulation suppressed OSCC development by enriching miR-488. CONCLUSIONS: Circ_0000745 regulated the expression of CCND1 partly by acting as miR-488 sponge and interacting with HuR protein, thus promoting the progression of OSCC.
other	34020619	hsa-mir-1228	Uterine Cervical Neoplasms	CONCLUSION: From above concern, it can conclude that hsa_circ_0000301/hsa-miR3p/IRF4 may be involved in the occurrence and development of cervical cancer.
other	34020433	hsa-mir-21	Breast Neoplasms	Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur.
other	34020433	hsa-mir-29a	Breast Neoplasms	Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur.
epigenetics	34020253	hsa-mir-29a	Scleroderma, Systemic	Our study highlights the therapeutic role of miR-29a-3p in SSc and the importance of regulating methylation and apoptosis.
other	34020163	hsa-mir-21	Ovarian Failure, Premature 	The study results inferred downregulation in the expression levels of miR-21 in ovarian tissues of PCOS patients and KGN cells, when compared with unaffected ovarian tissues and IOSE80 (human ovarian surface epithelial cell line).
other	34020163	hsa-mir-21	Polycystic Ovary Syndrome	The study results inferred downregulation in the expression levels of miR-21 in ovarian tissues of PCOS patients and KGN cells, when compared with unaffected ovarian tissues and IOSE80 (human ovarian surface epithelial cell line).
lncRNA target	34020142	hsa-mir-7	Carcinoma, Hepatocellular	5p could act as a tumor inhibitory factor in HCC.
transcription factor target	34019979	hsa-mir-181b	Pituitary Diseases	To conclude, butyrate prevents endothelial dysfunction in atherosclerosis by reducing endothelial NOX2 expression and ROS production via the PPARdelta/miR-181b pathway.
genetics_GWAS	34019714	hsa-mir-132	Carcinoma, Hepatocellular	The recovery experiments demonstrated that downregulation of miR-132/212 markedly eliminate the antitumor effects mediated by RBM5-AS1 silencing in HCC cells. The data of this work illustrate that RBM5-AS1 acts as an epigenetic regulator to promote the HCC progression by repressing miR-132/212 expressions, which would provide a new insight for understanding the action mechanism of RBM5-AS1 in HCC development.
genetics_GWAS	34019714	hsa-mir-212	Carcinoma, Hepatocellular	The recovery experiments demonstrated that downregulation of miR-132/212 markedly eliminate the antitumor effects mediated by RBM5-AS1 silencing in HCC cells. The data of this work illustrate that RBM5-AS1 acts as an epigenetic regulator to promote the HCC progression by repressing miR-132/212 expressions, which would provide a new insight for understanding the action mechanism of RBM5-AS1 in HCC development.
other	34019567	hsa-mir-222	Thyroid Cancer, Papillary	Especially MiR-222 and miR-146b may be prime candidates for the diagnosis of PTC in Asian population.
other	34019567	hsa-mir-146b	Thyroid Cancer, Papillary	Especially MiR-222 and miR-146b may be prime candidates for the diagnosis of PTC in Asian population.
other	34019487	hsa-mir-22	Carcinoma, Hepatocellular	In conclusion, this study suggests that chronic alcohol exposure promotes HCC progression and beta-catenin/miR3p/TET2 regulatory axis plays an important role in alcohol-promoted HCC malignancy.
lncRNA target	34018840	hsa-mir-200b	Liver Neoplasms	The lncRNA XIST promoted liver cancer cell proliferation, migration, and invasion in vitro, and acted as a molecular sponge for miR-200b-3p, and also regulated the expression of ZEB1/2 via miR-200b-3p. CONCLUSION: The lncRNA XIST is an oncogenic lncRNA that promotes liver cancer metastasis, and its pro-metastatic phenotype can be partially attributed to the lncRNA XIST/miR-200b-3p/ZEB1/2 signaling axis.
genetics_overexpression_promote	34018619	hsa-mir-630	Esophageal Squamous Cell Carcinoma	CONCLUSION: miR-630 overexpression can reduce EC cell invasion and migration, showing a possible key role of miR-630 in EC diagnosis and treatment in the future.
genetics_knock down_suppress	34018345	hsa-mir-221	Diabetic Neuropathies	Furthermore, knockdown of miR-221 remarkably decreased the expression of PEG2, BK, IL-6, IL-1beta, and TNF-alpha in both STZ-treated DPN rats and high glucose-induced SH-SY5Y cells, which was reversed by inhibition of SOCS3.
transcription factor target	34018309	hsa-mir-193b	Parkinson Disease	Our findings also revealed that miR-193b functions in PD development, possibly through regulating PGC-1alpha/FNDC5/BDNF pathway, suggesting miR-193b as a potential biomarker for PD diagnosis.
lncRNA target	34018092	hsa-mir-124	Esophageal Squamous Cell Carcinoma	By modulating miR-124/PD-L1 axis, silencing circ-VIM and applying sevoflurane both inhibited immune escape and multiple oncogenic activities of EC in vitro, and suppressed xenograft growth and lung metastases in vivo.
genetics_knock down_promote	34017919	hsa-mir-1229	Glioma	In vivo knockdown of circ_0037655 also suppressed glioma tumorigenesis by acting on the miR
lncRNA target	34017686	hsa-mir-146a	Osteosarcoma	MicroRNA analysis of SEVs from different malignant human osteosarcomas revealed that miR-146a-5p was involved in the inhibition of osteoclastogenesis.
target gene	34017681	hsa-mir-454	Colorectal Neoplasms	MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
other	34017558	hsa-mir-222	Coronary Disease	OBJECTIVE: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis. CONCLUSION: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%.
other	34017558	hsa-mir-221	Coronary Disease	OBJECTIVE: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis. CONCLUSION: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%.
genetics_overexpression_promote	34017500	hsa-mir-429	Carcinoma, Pancreatic Ductal	Overexpressed miR-429 restricted the mobility and proliferation of PDAC cells by restricting EMT, while down-regulated miR-429 had the opposite effect.
circulation_biomarker_prognosis_ns	34017498	hsa-mir-1269	Lung Neoplasms	METHODS: The miR-1269 expressions in the peripheral blood of LC patients, benign pulmonary disease (BPD) patients, and healthy controls were measured using qRT-PCR.
genetics_overexpression_promote	34017441	hsa-mir-21	Lung Injury	5p overexpression on the lung tissues of HILI rats can be partially blocked by MAP2K3 overexpression.
circulation_biomarker_diagnosis_down	34017415	hsa-mir-20	Smoke Inhalation Injury	CONCLUSION: Aerosol inhalation of edaravone in advance can reduce the levels of inflammatory factors and oxidative stress indexes in serum of smoke inhalation injury rats, thus protecting PF, which may be related to the down-regulation of miR-320 by edaravone.
lncRNA target	34017411	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	5p suppresses FOXK1 and accelerates apoptosis of tumor cells, which may serve as an therapeutic target for the treatment of NSCLC.
tissue_expression_ns	34017408	hsa-mir-663b	Burns	A deficiency of HULC promotes the proliferation, invasion, and ECM synthesis of HSF cells with thermal injury; HULC functions as a ceRNA of miR-663b.
exosome	34017395	hsa-mir-28	Myocardial Infarction	Furthermore, exogenous exosomal miR
lncRNA target	34017389	hsa-mir-20	Hypoxia	3p plays a certain role in the progression of hypoxic PH via KLF5 and HIF1alpha and might be a potent therapeutic tool for PH.
lncRNA target	34017389	hsa-mir-20	Hypertension, Pulmonary	3p plays a certain role in the progression of hypoxic PH via KLF5 and HIF1alpha and might be a potent therapeutic tool for PH.
other	34017389	hsa-mir-20	Diarrhea 5, With Tufting Enteropathy, Congenital	The results indicated that miR3p was downregulated in hypoxia-exposed rat PH models, hypoxia-induced PASMCs and chronic thromboembolic pulmonary hypertension (CTEPH) patients.
genetics_knock down_promote	34017387	hsa-mir-363	Carcinoma, Renal Cell	The expression of Snail1, Vimentin, N-cadherin, and E-cadherin in RCC cells was measured, and then the effect of loss-of-function of miR-363 and gain-of-function of Snail on RCC cells were analyzed.
target gene	34017385	hsa-mir-214	Prostatic Neoplasms	miR-214-5p targeted by LncRNA DANCR mediates TGF-β signaling pathway to accelerate proliferation, migration and inhibit apoptosis of prostate cancer cells.
genetics_knock down_promote	34017382	hsa-mir-338	Pancreatic Carcinoma	The inhibitory effects of circPCDH10 knockdown on PC cells could be notably reversed by miR
other	34017372	hsa-mir-423	Diabetic Nephropathies	5p-USF2 axis.
genetics_overexpression_promote	34017210	hsa-mir-19b	Colonic Neoplasms	RESULTS: The miR-19b was overexpressed and NR3C1 was decreased in colon cancer tissue and cell lines (SW480 and DLD-1).
other	34017077	hsa-mir-211	high grade glioma	The novel feedback loop among FMR1, circCHAF1A, miR5p, and HOXC8 in GSCs can facilitate the proliferation and tumorigenesis of glioma and GSCs.
exosome	34016964	hsa-mir-503	Breast Neoplasms	Exosomal microRNA-503-3p derived from macrophages represses glycolysis and promotes mitochondrial oxidative phosphorylation in breast cancer cells by elevating DACT2.
other	34016844	hsa-mir-27a	Ventricular Dysfunction, Right	As the current treatments cannot prevent the progression of the disease, we investigated whether 3 plant derivatives, namely perillyl alcohol (PA), quercetin (QS), and berberine (BBR), can improve RV function and affect the expression of miR-204, miR-27a, and biochemical factors in monocrotaline-induced PAH (MCT-PAH).
other	34016844	hsa-mir-27a	Pulmonary Arterial Hypertension	As the current treatments cannot prevent the progression of the disease, we investigated whether 3 plant derivatives, namely perillyl alcohol (PA), quercetin (QS), and berberine (BBR), can improve RV function and affect the expression of miR-204, miR-27a, and biochemical factors in monocrotaline-induced PAH (MCT-PAH).
circulation_biomarker_diagnosis_up	34016842	hsa-mir-340	von Hippel-Lindau Disease	The expression levels of miR-340 and von Hippel-Lindau tumor suppressor (VHL) in VSMCs induced by platelet-derived growth factor-BB or fetal bovine serum were measured by q-polymerase chain reaction.
genetics_knock down_promote	34016832	hsa-mir-30	Stomach Neoplasms	Knockdown of circ_ASAP2 promoted DDP sensitivity and suppressed malignant behaviors of DDP-resistant gastric cancer cells through targeting the miR3p/NT5E axis.
other	34016788	hsa-mir-454	Pituitary Neoplasms	3p/TNF-alpha in BIPAs.
other	34015968	hsa-mir-139	Intervertebral Disc Degeneration	In conclusion, lncRNA H19 facilitated the autophagy and apoptosis of DNPCs by the miR3p/CXCR4/NF-kappaB axis, thereby aggravating IDD.
genetics_overexpression_suppress	34015764	hsa-mir-588	Squamous Cell Carcinoma of Head and Neck	The overexpression of CXCR4 or miR-588 inhibitor could reverse circABCB10 depletion-attenuated malignant phenotypes of LSCC cells.
lncRNA target	34015763	hsa-mir-17	Intervertebral Disc Degeneration	Thus, we conclude that circITCH promotes ECM degradation in IDD by activating Wnt/beta-catenin through miR5p/SOX4 signaling.
other	34015762	hsa-mir-335	Osteosarcoma	The LOC100129620/miR3p/CDK6 signaling pathway promotes the metastasis of osteosarcoma by regulating the proliferation of osteosarcoma cells, angiogenesis, and macrophage polarization.
transcription factor target	34015413	hsa-mir-187	Brain Ischemia	Our findings demonstrate that the inhibition of miR1873p attenuated I/Rinduced cerebral injury by regulating seipin-mediated ERS.
other	34015321	hsa-mir-206	Glioblastoma	Further, miR-206/Twist axis is involved in EZH2-regulated malignancy of GBM cells.
other	34014027	hsa-mir-335	Obesity	Transcriptomic analyses of miRNA and mRNA in the epididymal WAT of obese rats using microarrays revealed that DATS decreased miRNA-335 expression and normalized the obesity-related mRNA transcriptomic signatures in epididymal WAT.
transcription factor target	34014023	hsa-mir-17	Diabetic Nephropathies	5p inhibition alleviates the apoptosis and fibrosis in high glucose-treated HMCs by targeting KIF23 activating Wnt/beta-catenin signaling.
circulation_biomarker_diagnosis_up	34013701	hsa-mir-29c	Acromegaly	CONCLUSION: Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control.
other	34013455	hsa-let-7a	Neurotic Disorders	3p, and miR-1202) were measured using real-time PCR.
other	34013455	hsa-mir-34a	Neurotic Disorders	3p, and miR-1202) were measured using real-time PCR.
other	34013455	hsa-mir-132	Neurotic Disorders	3p, and miR-1202) were measured using real-time PCR.
other	34013455	hsa-mir-17	Sexually Transmitted Diseases	Although a larger-scale analysis is needed due to the small number of subjects, these findings suggest that miR5p in NEVs is a potential biomarker for StD.
other	34013455	hsa-mir-26b	Neurotic Disorders	3p, and miR-1202) were measured using real-time PCR.
other	34013455	hsa-mir-17	Neurotic Disorders	3p, and miR-1202) were measured using real-time PCR.
lncRNA target	34013364	hsa-mir-17	Arthritis, Rheumatoid	Long noncoding RNA (lncRNA) LOC100912373 was identified as a key gene related to RA and has been proven to interact with miR175p, in order to regulate the pyruvate dehydrogenase kinase 1 and protein kinase B axis (PDK1/AKT axis). The present study aimed to determine whether AST may treat RA through the interaction between lncRNA LOC100912373 and the miR175p/PDK1 axis.
genetics_overexpression_promote	34013042	hsa-mir-28	Carcinoma, Non-Small-Cell Lung	5p overexpression-mediated influences in NSCLC cells were partly overturned by the addition of HIF-1alpha overexpression plasmid.
circulation_biomarker_diagnosis_ns	34012792	hsa-mir-4286	Carcinoma, Non-Small-Cell Lung	miR-4286 showed promise as a blood-based diagnostic biomarker that could distinguish between adenocarcinoma and SqCC histologies.
other	34012792	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	RESULTS: Differential expression of a 5-miR signature (miR-30a-3p, miR-30b-5p, miR-30c-5p, miR-34a-5p, miR-4286) demonstrated their ability to distinguish between normal and tumour lung tissue and between NSCLC histologies.
other	34012636	hsa-mir-625	Esophageal Neoplasms	Long non-coding RNA small nucleolar RNA host gene 7 facilitates the proliferation, migration, and invasion of esophageal cancer cells by regulating microRNA-625.
lncRNA target	34012590	hsa-mir-132	Carcinoma, Non-Small-Cell Lung	3p and restrained the development of tumor cells in NSCLC, the effects of which were attenuated via KLF7 over-expression.
circulation_biomarker_diagnosis_ns	34012511	hsa-mir-520e	Exanthema	RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash.
circulation_biomarker_diagnosis_ns	34012511	hsa-mir-21	Exanthema	RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash.
circulation_biomarker_diagnosis_ns	34012511	hsa-mir-1	Exanthema	RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash.
target gene	34012271	hsa-mir-338	Ovarian Neoplasms	CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway.
genetics_knock down_suppress	34012268	hsa-mir-873	Stomach Neoplasms	HNRNPK overexpression reversed the inhibitory impact of miR
lncRNA target	34012023	hsa-mir-1252	Osteoporosis	In summary, PAX8-AS1 suppressed the viability and activated the autophagy of osteoblasts via the miR5p/GNB1 axis in OP.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-4718	Drug-Induced Kidney Injury	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-3168	Head and Neck Neoplasms	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-4718	Head and Neck Neoplasms	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-6125	Head and Neck Neoplasms	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-6125	Drug-Induced Kidney Injury	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
circulation_biomarker_diagnosis_ns	34011306	hsa-mir-3168	Drug-Induced Kidney Injury	The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.
lncRNA target	34011046	hsa-mir-34a	Neuroblastoma	With all these evidences, we determined that miRNA-34a-5p regulated Wnt/beta-catenin pathway by targeting SOX4.In conclusion, our study demonstrates that miRNA-34a-5p can inhibit the over-activation of the Wnt/beta-catenin signaling pathway via targeting SOX4 and further regulate proliferation, invasion of neuroblastoma cells.
lncRNA target	34010654	hsa-mir-199a	Rett Syndrome	Moreover, miR-199a expression and treatment with BMP inhibitors rectify the differentiation of RTT patient-derived NS/PCs and development of brain organoids, respectively, suggesting that facilitation of BMP signaling accounts for the impaired RTT brain development. Our study illuminates the molecular pathology of RTT and reveals the MeCP2/miR-199a/Smad1 axis as a potential therapeutic target for RTT.
other	34010598	hsa-mir-107	Colorectal Neoplasms	Taken together, our results suggest that the miR-107/MCM7/PAK2 pathway may participate in cancer progression and that MCM7 may serve as a prognostic biomarker in CRC.
transcription factor target	34010470	hsa-mir-98	Alzheimer Disease	5p suppressed alpha7 nAChR expression through directly binding to the 3'UTR of mRNA.
other	34010469	hsa-mir-145	Eunuchism	These findings demonstrate that SC-derived miR5p plays a significant role in regulating the functions of Leydig cells and may therefore serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
genetics_knock down_promote	34010066	hsa-mir-579	Kidney Diseases	What's more, overexpression of GAS5, or knockdown of miR
genetics_knock down_promote	34010066	hsa-mir-579	Sepsis	What's more, overexpression of GAS5, or knockdown of miR
genetics_overexpression_promote	34009856	hsa-mir-9	Myocardial Infarction	CircJARID2 overexpression contributed to the hypoxia-induced H9c2 cell injury by sponging miR5p to upregulate BNIP3 expression, showing a novel molecular network of MI pathomechanism.
other	34009437	hsa-mir-195	Obesity	CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT.
other	34009437	hsa-mir-195	Diabetes Mellitus, Type 2	CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT.
other	34009437	hsa-mir-27	Diabetes Mellitus, Type 2	CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT.
other	34009437	hsa-mir-27	Obesity	CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT.
lncRNA target	34009012	hsa-mir-519a	Ovarian Neoplasms	Conclusion: PARP1, a target gene of miR-519a-3p, promoted the migration, invasion, and tube formation of OC cells, providing a possible therapeutic target for treatment of OC patients.
circulation_biomarker_diagnosis_ns	34008755	hsa-mir-141	Neonatal Sepsis	In conclusion, serum decreased miR-141 expression served as a candidate diagnostic biomarker of neonatal sepsis.
lncRNA target	34008749	hsa-mir-29a	Carcinoma, Hepatocellular	Furthermore, KCNQ1OT1 exerted tumor promotion in HCC cells via suppressing miR-29a-3p to regulate CBX3 expression.
lncRNA target	34008270	hsa-mir-124	Cataract, Age-Related	CONCLUSION: This study revealed that miRNA-124 promotes LEC apoptosis in ARC by upregulating mFas through targeted inhibition of PTB.
transcription factor target	34008206	hsa-mir-124	Neuralgia	Targeting miR3p might be a promising therapeutic strategy in the treatment of chronic pain.
transcription factor target	34007335	hsa-mir-135a	Depression	In conclusion, the findings of the present study indicate that miR-135a may be a novel potential target for the treatment of depression.
circulation_biomarker_diagnosis_ns	34007326	hsa-mir-23a	Pulmonary Disease, Chronic Obstructive	Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD.
circulation_biomarker_diagnosis_ns	34007326	hsa-mir-574	Pulmonary Disease, Chronic Obstructive	Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD.
circulation_biomarker_diagnosis_ns	34007326	hsa-mir-221	Pulmonary Disease, Chronic Obstructive	Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD.
genetics_knock down_promote	34007324	hsa-mir-141	Cardiomyopathies	In summary, the present study indicated that upregulated SGLT2 expression in cardiac fibrosis following MI was regulated by miR-141 and SGLT2 that knockdown reduced cardiac fibrosis and improved cardiac function after MI.
genetics_knock down_promote	34007313	hsa-mir-378	Esophageal Squamous Cell Carcinoma	miR-378 mimic and miR-378 inhibitor was transfected into ESCC cells to overexpress or knockdown miR-378 expression levels in ESCC cells.
lncRNA target	34007276	hsa-mir-340	Carcinoma, Hepatocellular	5p, which has been reported to directly inhibit ATF7 expression in HCC cells.
other	34007244	hsa-mir-6869	Diabetes, Gestational	5p is involved in maintaining placental microenvironment balance by preventing from inflammation and inducing M2 macrophages in gestational diabetes mellitus.
other	34007214	hsa-mir-7	Ovarian Neoplasms	LNC00115 Mediates Cisplatin Resistance by Regulating the miR-7/ERK Signalling Pathway in Ovarian Cancer.
lncRNA target	34007212	hsa-mir-138	Stomach Neoplasms	5p, the inhibition of which could attenuate silenced circ_CORO1C-induced inhibitory effects on GC progression.
lncRNA target	34007211	hsa-mir-4319	Carcinoma, Non-Small-Cell Lung	Furthermore, PCAT18 silencing inhibited NSCLC cell proliferation, migration and invasion, while co-transfection with a miR-4319 inhibitor reversed these biological effects, and miR-4319 inhibited NSCLC growth in vivo. CONCLUSION: In conclusion, these findings demonstrated that PCAT18 promoted NSCLC development by sponging miR-4319.
tissue_expression_ns	34007200	hsa-mir-223	Panniculitis, Peritoneal	MiR-223 deficiency also markedly aggravated inflammatory cells infiltration and cytokines release including interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein-1 (MCP-1) in the air pouch and peritonitis models.
transcription factor target	34007200	hsa-mir-223	Dyssegmental dysplasia, Rolland-Desbuquois type	CONCLUSION: MiR-223 was down-regulated in gout patients and miR-223 deficiency exacerbated inflammatory response in diverse murine models, suggesting that up-regulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflammation.
transcription factor target	34007200	hsa-mir-223	Gout	CONCLUSION: MiR-223 was down-regulated in gout patients and miR-223 deficiency exacerbated inflammatory response in diverse murine models, suggesting that up-regulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflammation.
target gene	34007185	hsa-mir-422a	Thyroid Neoplasms	Long Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis.
lncRNA target	34007135	hsa-mir-128	Pancreatic Carcinoma	Mechanistically, TP73-AS1 was validated to promote PC progression through GOLM1 upregulation by competitively binding to miR
lncRNA target	34006929	hsa-mir-378c	Atherosclerosis	Our results provided a better understanding of atherosclerosis pathophysiology and potential therapeutic management by targeting miR-378c-Samd1 circuit.
transcription factor target	34006907	hsa-mir-23a	Hematologic Neoplasms	Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo.
transcription factor target	34006907	hsa-mir-503	Hematologic Neoplasms	Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo.
other	34006268	hsa-mir-1275	Diabetes Mellitus, Type 1	Two miRNAs (hsa-miR-181a and hsa-miR-1275) were screened as T1DM-related miRNAs to build the T1DM-related ceRNA regulatory network, in which genes were considerably enriched in seven pathways.
other	34006268	hsa-mir-181a	Diabetes Mellitus, Type 1	Two miRNAs (hsa-miR-181a and hsa-miR-1275) were screened as T1DM-related miRNAs to build the T1DM-related ceRNA regulatory network, in which genes were considerably enriched in seven pathways.
genetics_knock down_promote	34006084	hsa-mir-1266	Carcinoma, Hepatocellular	5p knockdown significantly inhibited the proliferation, migration and invasion of HCC cells.
circulation_biomarker_diagnosis_up	34004247	hsa-mir-150	Sepsis	In human, the serum level of miR-150 was down-regulated in septic patients and elevated in non-septic trauma patients compared to healthy controls.
circulation_biomarker_diagnosis_up	34004232	hsa-mir-486	COVID-19	Interestingly, another research group recently reported miR3p is upregulated in blood samples from severe COVID-19 patients who suffer from bradycardia.
circulation_biomarker_diagnosis_up	34004232	hsa-mir-486	Bradycardia	Interestingly, another research group recently reported miR3p is upregulated in blood samples from severe COVID-19 patients who suffer from bradycardia.
genetics_knock down_suppress	34004029	hsa-mir-433	Bone Diseases	Local delivery of miR3p inhibitor could present a strategy for the management of bone loss disorders and bone defect repair.
other	34003899	hsa-mir-23a	Cataract	RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05).
other	34003899	hsa-mir-125a	Cataract	RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05).
other	34003899	hsa-let-7d	Cataract	Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts.
other	34003899	hsa-let-7a	Cataract	Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts.
other	34003899	hsa-mir-23b	Cataract	RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts.
other	34003899	hsa-let-7g	Cataract	RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts.
transcription factor target	34003896	hsa-mir-19a	Macular Degeneration	Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis.
transcription factor target	34003896	hsa-mir-126	Macular Degeneration	Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis.
transcription factor target	34003896	hsa-mir-410	Macular Degeneration	Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis.
lncRNA target	34003875	hsa-mir-510	Squamous Cell Carcinoma of Head and Neck	The results indicated there was a high expression of LINC00958 in ESCC, which promoted proliferation, migration, invasion and Epithelial-Mesenchymal Transition (EMT) of ESCC cells, and this effect may be via regulating miR5p.
lncRNA target	34003551	hsa-mir-522	Colonic Neoplasms	Taken together, our study confirmed that BVES-AS1 inhibited COAD progression via interacting with miR3p and TAF15 to regulate BVES expression, which might offer a perspective for COAD treatment.
lncRNA target	34003544	hsa-mir-199a	Breast Neoplasms	These results support a regulatory axis consisting of HIF-1, SNHG1, miR-199a-3p, and TFAM during BC development and metastasis under hypoxic conditions, providing an opportunity to develop targeted therapeutics for BC.
genetics_overexpression_promote	34003510	hsa-mir-497	Squamous Cell Carcinoma of Head and Neck	Also, LncRNA FGD5-AS1 overexpression increased cisplatin-resistance in LSCC by modulating the miR
circulation_biomarker_diagnosis_ns	34003488	hsa-mir-146a	Lupus Erythematosus, Systemic	This study aimed to evaluate the presence of miR-126 and miR-146a in plasma MPs of patients with SLE (SLE MPs) and analyse the ability of MPs to modulate some events in the promonocytic U937 cell line. SLE MPs contained decreased levels of miR-146a, but the miR-126 content in aSLE MPs was increased.
lncRNA target	34002676	hsa-mir-122	Cardiomyopathies	5p may mitigate sepsis-triggered myocardial injury through inhibiting inflammation, oxidative stress and apoptosis via targeting GIT1, which provides a possible therapeutic target for sepsis.
transcription factor target	34002673	hsa-mir-429	Pre-Eclampsia	In addition, targeting miR-429 might treat PE.
circRNA target	34002672	hsa-mir-140	Carcinoma, Hepatocellular	Mechanistically, circ_0008274 upregulates GRN expressions via adsorbing miR
other	34002670	hsa-mir-490	Stomach Neoplasms	In conclusion, lncRNA AL139002.1 was highly expressed in GC cells, and lncRNA AL139002.1/miR3p/HAVCR1 functioned critically in GC by regulating MEK/ERK signaling.
circulation_biomarker_diagnosis_ns	34002665	hsa-mir-146a	Asthma	In this work, we proved that miR-146a-5p expression was inhibited in asthma patients' plasma and platelet activating factor (PAF)-induced human small airway epithelial cells (HSAECs).
genetics_overexpression_promote	34002647	hsa-mir-24	Esophageal Squamous Cell Carcinoma	Additionally, overexpressed miR
transcription factor target	34002613	hsa-mir-1266	Atrial Fibrillation	It may be that miR-1266 is an antiarrhythmic miRNA and an AF intervention target in the future (Tab.
lncRNA target	34002487	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	Our data indicated that SNHG12 targeted and negatively regulated miR
lncRNA target	34002485	hsa-mir-140	Ovarian Neoplasms	H19 upregulated Wnt1 expression through targeting miR-140 in OC cells.
genetics_overexpression_suppress	34002462	hsa-mir-10a	Carcinoma, Hepatocellular	In particular, the overexpression of SKA1 reversed the inhibitory effects of miR-10a-5p in HCC.
other	34002325	hsa-mir-452	Enterovirus Infections	The results suggested that miR-18a and miR-452 repress the reproduction of EV71 virus by binding to VP3. Moreover, EV71 infection also affected the expression of endogenous miR-18a and miR-452.
other	34002325	hsa-mir-18a	Enterovirus Infections	The results suggested that miR-18a and miR-452 repress the reproduction of EV71 virus by binding to VP3. Moreover, EV71 infection also affected the expression of endogenous miR-18a and miR-452.
other	34001972	hsa-mir-375	Neuroendocrine Tumors	Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. Taken together, we provide compelling evidence that a miR-375/YAP axis is a critical mediator of neuroendocrine differentiation and tumorigenesis in lung carcinoid cells.
lncRNA target	34001919	hsa-mir-24	Nervous System Diseases	Characterisation of microRNAs that produce an effect on neurological activity, such as miR-324, and identification of the pathways they regulate will allow a better understanding of the processes involved in normal neurological function and in turn may present novel pharmaceutical targets in treating neurological disease.
lncRNA target	34001703	hsa-mir-138	Carcinoma, Renal Cell	Curcumin suppressed renal carcinoma tumorigenesis in vitro and in vivo via regulating circ-FNDC3B/miR
other	34001212	hsa-mir-124	Asthma	Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma.
other	34001212	hsa-mir-133b	Asthma	Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma.
other	34001212	hsa-mir-130a	Asthma	Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma.
genetics_overexpression_promote	34001147	hsa-mir-129	Carcinoma, Renal Cell	Overexpressed miR
circRNA target	34001137	hsa-mir-137	Stomach Neoplasms	Moreover, PBX3, a target of miR-137, play a DB-resistant role in GC cells.
genetics_overexpression_suppress	34001135	hsa-mir-139	Glioma	5p overexpression inhibited cell proliferation, migration, and invasion of glioma in vitro.
genetics_overexpression_suppress	34000513	hsa-mir-184	Breast Neoplasms	It was also found miR-184 expression was high in the BC cell lines treated with tripterine and that miR-184 overexpression reduced the viability, proliferation, and invasion abilities of BC cells under tripterine treatment.
exosome	34000376	hsa-mir-155	Intervertebral Disc Degeneration	BMSC exosomes increase miR-155 expression in NPCs, which targets Bach1 and in turn upregulates HO-1 expression, activates autophagy in NPCs, inhibits the apoptosis level, and improves intervertebral disc degeneration.
transcription factor target	34000275	hsa-mir-494	Macular Degeneration	MiR494-3p may be a candidate molecular target of diagnosis and therapy for age-related macular degeneration.
circulation_biomarker_diagnosis_up	33999859	hsa-mir-103a	Carcinoma, Non-Small-Cell Lung	Pumilio2 (Pum2) bound with miR-103a-3p in cytoplasm and nucleus, and facilitated packaging into CAF-derived exosomes in NSCLC cells.
lncRNA target	33999777	hsa-mir-155	Thyroid Carcinoma, Anaplastic	Our research proved that AFAP-AS1 could facilitate progression of thyroid cancer sponging miR5p through ETS1/ERK pathway.
lncRNA target	33999393	hsa-mir-223	Myocardial Infarction	3p may downregulate PIK3C2A expression, resulting in the inhibition of myocardial cell apoptosis in rats with myocardial infarction via the activation of PI3K/Akt signaling pathway.
other	33999360	hsa-mir-3156	Breast Neoplasms	Collectively, TPT1-AS1 diminished cell proliferation and sensitized cells to chemotherapy by sponging miR5p and upregulating CASP2, acting as a biomarker for patients with breast cancer.
genetics_knock down_promote	33999341	hsa-mir-135b	Neurotic Disorders	The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS.
genetics_knock down_promote	33999341	hsa-mir-135b	Campomelia Cumming type	The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS.
genetics_knock down_promote	33999341	hsa-mir-135b	Depressive Disorder	The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS.
other	33999095	hsa-mir-146	Epidural   Fibrosis	The upregulation of miR-146 enhanced the fibroblasts proliferation and inflammatory response in epidural fibrosis.
circulation_biomarker_diagnosis_ns	33997822	hsa-mir-375	Teratoma	Our results confirm prior reports that serum miR-375 cannot predict teratoma, and suggest that there may not exist a predictive serum miRNA for teratoma.
other	33997317	hsa-mir-21	Diabetic Foot	A previous report showed that NFkappaB-miR-21 pathway could serve as an innovative alternative to devise therapeutics for healing diabetic ulcers.
therapeutic target	33997273	hsa-mir-499	Lung Neoplasms	MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65.
genetics_overexpression_promote	33997050	hsa-mir-942	Colorectal Neoplasms	5p overexpression.
circulation_biomarker_diagnosis_ns	33997016	hsa-mir-146a	Myasthenia Gravis	OBJECTIVE: To investigate the expression and clinical significance of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) in myasthenia gravis (MG) patient serum.
other	33997006	hsa-mir-373	Hypoxia-Ischemia, Brain	In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1alpha, MMP-9, and VEGF.
other	33996940	hsa-mir-146b	Cardiotoxicity	Differential expression analysis of miRNAs profiling identified mir-146b to be up-regulatein (FC = 14, p = 0.046) in patients with CVAE.
other	33996940	hsa-mir-146b	Multiple Myeloma	Differential expression analysis of miRNAs profiling identified mir-146b to be up-regulatein (FC = 14, p = 0.046) in patients with CVAE.
lncRNA target	33996578	hsa-mir-212	Carcinoma, Non-Small-Cell Lung	In addition, ILF3-AS1 negatively controlled miR-212, which in turn targeted SMAD1 expression, thereby regulating NSCLC cell viability and apoptosis.
other	33996574	hsa-mir-139	Pancreatic Neoplasms	Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p.
other	33996574	hsa-mir-196b	Pancreatic Neoplasms	Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p.
target gene	33996559	hsa-mir-138	Breast Neoplasms	LINC00467 promotes progression of breast cancer through interacting with miR-138-5p and LIN28B directly
target gene	33996547	hsa-mir-326	Stomach Neoplasms	circATP2B1 Promotes Aerobic Glycolysis in Gastric Cancer Cells Through Regulation of the miR-326 Gene Cluster.
lncRNA target	33996428	hsa-mir-198	Osteosarcoma	CONCLUSION: Circ_0010220 contributes to osteosarcoma progression through mediating miR-198/STX6 axis, which might be a novel therapeutic target for osteosarcoma therapy.
circRNA target	33996257	hsa-mir-149	Thyroid Cancer, Papillary	Overall, our study pinpoints the oncogenic role of TR4 in PTC development, and the targeting of TR4/circ-FLNA/miR
lncRNA target	33996254	hsa-mir-429	Fatty Liver	dependent inhibition of PPARalpha, leading to cholesterol accumulation in liver and the occurrence of fatty liver.
exosome	33995992	hsa-mir-21	Arthritis, Rheumatoid	Collectively, BMSCs-derived EVs relieved RA by delivering miR-21, while the exosomal miR-21 alleviated RA through targeting the TET1/KLF4 regulatory axis.
lncRNA target	33995991	hsa-mir-144	Arthritis, Rheumatoid	3p/ROCK2/WNT in RA was investigated as a potential target for RA therapy.
other	33995948	hsa-mir-126	Asthma	c-kit+ cells had the potential to diminish asthma-related pathologies presumably by controlling the transcription of miRNA-126 and -133.
other	33995948	hsa-mir-133	Asthma	c-kit+ cells had the potential to diminish asthma-related pathologies presumably by controlling the transcription of miRNA-126 and -133.
lncRNA target	33995660	hsa-mir-138	Myocardial Infarction, Acute	Conclusions: Our findings suggest that M2M-derived circUbe3a-containing SEVs promote the proliferation, migration, and phenotypic transformation of CFs by directly targeting the miR5p/RhoC axis, which may also exacerbate myocardial fibrosis after acute myocardial infarction.
target gene	33995647	hsa-mir-146b	Pancreatic Neoplasms	MiR-146b-3p regulates proliferation of pancreatic cancer cells with stem cell-like properties by targeting MAP3K10.
other	33995620	hsa-mir-663	Carcinoma, Hepatocellular	In summary, acidic pH(e) enhances anoikis resistance of HCC cells by inducing autophagy, which is regulated by miR3p.
other	33995497	hsa-mir-6512	Non-alcoholic Fatty Liver Disease	Conclusion: The crosstalk of hsa_circ_0000313-hsa-miR3p-PEG10 and some related non-coding RNAs may take part in NAFLD's pathogenesis, which could be the potential biomarkers of NAFLD in the future.
other	33995494	hsa-mir-1	Familial Primary Pulmonary Hypertension	3p could regulate gene expression in IPAH.
lncRNA target	33995003	hsa-mir-186	Femur Head Necrosis	Inhibition of miR-186 reversed the protection of Ato on SANFH rats, while inhibition of TLR4 restored the protective effect of Ato.
lncRNA target	33994849	hsa-mir-218	Stomach Neoplasms	Negatively modulated by YY1, SNHG12 promotes GC metastasis and EMT by regulating the miR5p/YWHAZ axis and stabilizing CTNNB1 via activation of the beta-catenin signaling pathway.
genetics_knock down_suppress	33994812	hsa-mir-128	Glioma	Furthermore, the effects of HCP5 knockdown on radiosensitivity of glioma cells were attenuated by the inhibitor of miR-128.
exosome	33994542	hsa-mir-4717	Lymphoma	Our results suggest that exosomes including miR5p secreted from CAFs play a pivotal role in the lymphoma microenvironment, indicating that they are a promising therapeutic target.
genetics_knock down_promote	33994521	hsa-mir-99a	Glioma	Furthermore, miR-99a was involved in the circGFRA1-regulated glioma cell behaviors. In conclusion, our study demonstrated that knockdown circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a.
lncRNA target	33994508	hsa-mir-518a	Myocardial Infarction	More importantly, the miR-518a-5p mimic enhanced cell proliferation and repressed apoptosis of H/R-injured HUVEC cells by inhibiting GZMB expression.We proved that miR-518a-5p could partly attenuate H/R-induced HUVEC cell injury by targeting GZMB, and perhaps the miR-518a-5p/GZMB axis could be potential therapeutic targets for myocardial infarction.
circulation_biomarker_diagnosis_ns	33994501	hsa-mir-210	Sepsis	The above cellular and molecular alterations in H9C2 cells induced by septic serum were enhanced by miR
circulation_biomarker_diagnosis_ns	33994501	hsa-mir-210	Cardiomyopathies	The above cellular and molecular alterations in H9C2 cells induced by septic serum were enhanced by miR
transcription factor target	33994349	hsa-mir-139	Staphylococcal Infections	aureus-infected wound healing, suggesting that JTXK or other miR5p suppressants may be effective for treating infected skin wounds.
other	33994260	hsa-mir-125b	psoriasis 1	Moreover, the expression of miR-125b could be substantially decreased within psoriasis lesion tissue samples, while miR-125b could negatively regulate the SH3PXD2A-AS1 and STAT3 expression. A novel STAT3 related mechanism whereby STAT 3/ SH3PXD2A-AS1/ miR-125b/STAT3 positive feedback loop which could potentially affect the pathogenesis of Psoriasis has been established.
lncRNA target	33993846	hsa-mir-128	Stomach Neoplasms	HCP5 aggravated the resistance of GC cells to DDP in vitro by elevating HMGA2 expression via sponging miR-128.
genetics_GWAS	33993456	hsa-mir-216b	Glaucoma	Targeting the epigenetic axis of LINC01518/hsa-miR-216b-5p may provide new insight into the pathological development of human glaucoma.
lncRNA target	33993382	hsa-mir-662	Pancreatic Carcinoma	CONCLUSIONS: This study sheds light on miRNA-3662 inhibits PDAC cell chemoresistance and aerobic glycolysis through a negative feedback loop with HIF-1a.
lncRNA target	33993369	hsa-mir-183	Glioma	5p targeted TUSC2 and miR
transcription factor target	33993322	hsa-mir-217	Prostatic Neoplasms	5p inhibited the expression of EMT-related proteins by regulating the expression of the target gene CLU, and further inhibited the invasion and migration of prostate cancer cells.
lncRNA target	33993193	hsa-mir-16	Stomach Neoplasms	Our research indicates that LINC00473/miR5p/CCND2 axis plays a role in the proliferation of GC and modulates AQP3 to influence GC cell metastasis, making it a potential therapeutic target for GC.
lncRNA target	33993032	hsa-mir-155	Abortion, Habitual	In conclusion, the miRNA5p can not only promote the growth and proliferation but also inhibit the apoptosis of decidua stromal cells depending on inhibiting NF-kappaB signaling pathway in recurrent miscarriage.
other	33992764	hsa-mir-20a	Hepatitis B, Chronic	Finally, miR5p was positively correlated with titer of hepatitis B virus DNA (r = 0.438, P = 0.008) and hepatitis B e antigen (r = 0.610, P < 0.001), and miR-320a-3p was negatively correlated with hepatitis B virus DNA titer (r = -0.366, P = 0.028) at baseline.
other	33992764	hsa-mir-122	Hepatitis B, Chronic	Finally, miR5p was positively correlated with titer of hepatitis B virus DNA (r = 0.438, P = 0.008) and hepatitis B e antigen (r = 0.610, P < 0.001), and miR-320a-3p was negatively correlated with hepatitis B virus DNA titer (r = -0.366, P = 0.028) at baseline.
genetics_knock down_promote	33992709	hsa-mir-15a	Glioma	CONCLUSION: LINC00511 knockdown inhibits glioma cell progression via miR-15a-5p/AEBP1 axis.
genetics_overexpression_promote	33992597	hsa-mir-761	Colorectal Neoplasms	CircMYH9 overexpression protected CRC cells from Baicalin-induced injury partly through down-regulating miR-761.
other	33992122	hsa-mir-212	Osteochondrodysplasias	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-7	Osteochondrodysplasias	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-212	Norrie disease	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-378	Osteochondrodysplasias	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-20a	Norrie disease	Our results showed that miRNA-320a was significantly different in top-quality embryos versus non-top-quality embryos on day 3 in NOR patients with a sensitivity of 80% and specificity of 71%, (AUC=[0.753 (0.651; 0.855)], p=0.001).
other	33992122	hsa-mir-224	Osteochondrodysplasias	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-212	Polycystic Ovary Syndrome	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-7	Polycystic Ovary Syndrome	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-224	Norrie disease	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-7	Norrie disease	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-224	Polycystic Ovary Syndrome	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-378	Polycystic Ovary Syndrome	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
other	33992122	hsa-mir-378	Norrie disease	3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients.
lncRNA target	33991848	hsa-mir-139	Glioblastoma	CONCLUSIONS: Our study supports a tumorigenic role for RP3-439F8.1 in GBM through the RP3-439F8.1/miR
genetics_overexpression_promote	33991762	hsa-mir-128	Carcinoma, Hepatocellular	And the effects of overexpressed CDC6 on inhibiting E-Cadherin expression yet promoting MMP2, MMP9, N-Cadherin and Vimentin expressions in HCC cells were reversed by up-regulating miR
lncRNA target	33991434	hsa-mir-143	Bone Diseases	The lncRNA AC092155/miR3p/STMN1 axis may be a new therapeutic target for bone-related diseases.
genetics_GWAS	33991356	hsa-mir-7	Parkinson Disease	miR-7 and miR-30, implied in the pathogenesis of PD and in the post-transcriptional control of alpha-synuclein and NLRP3 expression, were also increased in PD. CONCLUSIONS: Mononuclear cells of newly diagnosed PD subjects display a hyper-expression of the P2X7R/NLRP3 inflammasome platform that seems to modulate cellular alpha-synuclein content and is reduced after PD treatment; an impaired JNK phosphorylation might be the intracellular signalling mediating this effect, undergoing an epigenetic regulation by miR-7 and miR-30.
transcription factor target	33990905	hsa-mir-519d	high grade glioma	Other genes such as MIR519D and NOP53 are also discovered as tumor suppressor genes in gliomas which are located on 19q13.3 and 19q13.4, respectively.
other	33990872	hsa-mir-4417	Prostatic Neoplasms, Castration-Resistant	Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated.
other	33990872	hsa-mir-195	Prostatic Neoplasms, Castration-Resistant	Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated.
other	33990872	hsa-mir-3687	Prostatic Neoplasms, Castration-Resistant	Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated.
other	33990872	hsa-mir-205	Prostatic Neoplasms, Castration-Resistant	RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated.
other	33990872	hsa-mir-92b	Prostatic Neoplasms, Castration-Resistant	RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated.
other	33990669	hsa-mir-210	Melanoma	Based on the results of measurements of mitochondrial resipiratory activity, ROS production, and changes in the metabolites obtained in cells under the observed conditions, we concluded that silencing of HIF-1alpha and miR-210 yields apoptosis and, ultimately, apoptotic cell death in A375 melanoma cells.
lncRNA target	33990639	hsa-mir-34a	Uterine Cervical Neoplasms	5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR.
lncRNA target	33990639	hsa-mir-21	Uterine Cervical Neoplasms	5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR.
circulation_biomarker_diagnosis_ns	33990639	hsa-mir-145	Uterine Cervical Neoplasms	5p, and miR-34a-5p in urine yielded 100% sensitivity and 92.8% specificity in distinguishing precancer and cancer patients from healthy controls and it well correlates with those of serum and tumor tissues.
lncRNA target	33990639	hsa-mir-218	Uterine Cervical Neoplasms	5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR.
genetics_knock down_promote	33990540	hsa-mir-135b	Carcinoma, Non-Small-Cell Lung	Overexpressing miR-135b significantly promoted the aggressiveness of NSCLC, as evidenced by enhanced cell proliferation, migration, invasion, anti-apoptosis, and angiogenesis in vitro and in vivo, and knockdown of miR-135b had the opposite effects.
circRNA target	33990513	hsa-mir-149	Angelman Syndrome	Circ_CHFR promoted the proliferation, invasion, and migration of PDGF-BB-induced HVSMCs through miR5p/NRP2 axis, providing a new insight into the pathogenesis of AS and a potential therapeutic target for AS treatment.
lncRNA target	33990028	hsa-mir-210	Pre-Eclampsia	MicroRNA-210 (miR-210) can decrease trophoblast cell migration and invasion and may act as a biomarker for preeclampsia. LncRNA maternally expressed gene 3 (MEG3) plays a positive role in pre-eclampsia, and MEG3 can be a downstream target of miR-210 in human umbilical vein endothelial cells (HUVEC).
lncRNA target	33989902	hsa-mir-574	Breast Neoplasms	Together, MAFG-AS1 acts as an oncogene via regulation of miR5p/SOD2 axis in BC cells.
other	33989778	hsa-mir-7	Diabetes Mellitus	CONCLUSIONS: Our study indicates that miRmediated beta-cell dedifferentiation induces EMT signalling and a chronic response to tissue injury, which alters the islet microenvironment and predisposes to fibrosis.
genetics_overexpression_promote	33989616	hsa-mir-1224	Anodontia	H9C2 cells under H/R conditions displayed increased synthesis of ROS, along with overexpression of miR-1224 and downregulation of GPX4.
other	33988168	hsa-mir-155	Breast Neoplasms	This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls.
other	33988168	hsa-mir-125	Breast Neoplasms	This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls.
other	33988168	hsa-mir-21	Breast Neoplasms	This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls.
lncRNA target	33988127	hsa-mir-350	Myocardial Reperfusion Injury	These findings suggest lncRNA AK020546 protects against ischemia/reperfusion and oxidative stress injury by sequestering miR3p and activating ErbB3, which highlights its potential as a therapeutic target for ischemic heart diseases.
genetics_overexpression_promote	33988065	hsa-mir-425	Retinoblastoma	Additionally, circMKLN1 overexpression hampered tumor growth in vivo.Conclusions: CircMKLN1 overexpression decelerated the progression of RB through sponging miR
other	33987861	hsa-mir-21	Osteosarcoma	"This research work has introduced an identification of an osteosarcoma biomarker ""miRNA-21"" on the interdigitated electrochemical sensor by nuclease digestion. This nuclease digestion technique with miRNA-21 identification helps in detecting osteosarcoma and related issues."
lncRNA target	33987822	hsa-mir-199a	Endometriosis	These findings suggest that hsa-miR-199a-3p may act as a tumor suppressor in endometriosis development.
lncRNA target	33987822	hsa-mir-199a	Autoimmune Lymphoproliferative Syndrome	Transfection of hsa-miR-199a-3p inhibited the migration, invasion, and contractility of ECSCs via inhibition of PAK4 mRNA expression.
target gene	33987474	hsa-mir-542	Neuroblastoma	MiR-542-3p Suppresses Neuroblastoma Cell Proliferation and Invasion by Downregulation of KDM1A and ZNF346.
target gene	33987473	hsa-mir-326	Lung Neoplasms	Sevoflurane Inhibits Proliferation, Invasion, but Enhances Apoptosis of Lung Cancer Cells by Wnt/β-catenin Signaling via Regulating lncRNA PCAT6/miR-326 Axis.
other	33987373	hsa-mir-1261	Carcinoma, Hepatocellular	Additionally, luciferase assays and RNA immunoprecipitation (RIP) assays were used to explore the interactions of circ0097009, microRNA-1261 (miR-1261), and solute carrier family 7 member 11 (SLC7A11) in HCC. CONCLUSIONS: Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in HCC.
other	33987373	hsa-mir-1261	Thyroid Cancer, Papillary	Additionally, luciferase assays and RNA immunoprecipitation (RIP) assays were used to explore the interactions of circ0097009, microRNA-1261 (miR-1261), and solute carrier family 7 member 11 (SLC7A11) in HCC. CONCLUSIONS: Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in HCC.
genetics_overexpression_suppress	33987352	hsa-mir-194	Myocardial Reperfusion Injury	CONCLUSIONS: Our study shows overexpression of miR
virus_miRNA	33987336	hcmv-mir-US5-1	adverse pregnancy outcomes	plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls.
virus_miRNA	33987336	hcmv-mir-UL148D	adverse pregnancy outcomes	plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls.
virus_miRNA	33987336	hcmv-mir-US25-1	adverse pregnancy outcomes	plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls.
target gene	33987194	hsa-mir-3	Breast Neoplasms	hsa-miR-33-5p as a Therapeutic Target Promotes Apoptosis of Breast Cancer Cells via Selenoprotein T.
circulation_biomarker_prognosis_up	33987186	hsa-mir-107	Lymphoma, Large B-Cell, Diffuse	3p were detected in the plasma of DLBCL patients and showed potential diagnostic value.
lncRNA target	33987098	hsa-mir-1301	Stomach Neoplasms	3p as a novel potential therapeutic target that is associated with the tumorigenesis and progression of gastric cancer.
other	33987074	hsa-mir-9	Disease	5p activated the SIRT1/NF-kappaB pathway to promote wear-particle-induced osteoclastogenesis.
transcription factor target	33987074	hsa-mir-9	Yaws	5p may be a useful therapeutic target for PIO remission and treatment.
tissue_expression_ns	33986977	hsa-mir-144	Pelizaeus-Merzbacher Disease	In the present work, we evaluated the gene expression of miR
lncRNA target	33986977	hsa-mir-381	Pelizaeus-Merzbacher Disease	3p increased throughout the first 24 h of PMI, contrary to miR-23b-3p.
lncRNA target	33986977	hsa-mir-23b	Pelizaeus-Merzbacher Disease	3p increased throughout the first 24 h of PMI, contrary to miR-23b-3p.
target gene	33986876	hsa-mir-223	Breast Neoplasms	miR-223-3p may promote cell proliferation, migration, invasion and EMT through the Hippo/Yap signaling pathway.
genetics_knock down_promote	33986875	hsa-mir-383	Lymphoma, Large B-Cell, Diffuse	5p knockdown.
genetics_overexpression_promote	33986868	hsa-mir-891a	Carcinoma, Non-Small-Cell Lung	In addition, the experiments revealed that NSCLC cell proliferation, invasion and migration were significantly increased by the overexpression of miR-891a-5p and were significantly reduced by its downregulation.
genetics_overexpression_promote	33986863	hsa-mir-4417	Uterine Cervical Neoplasms	However, overexpression of miR-4417 inhibited CSCC cell invasion and migration, and attenuated the effects of PSMG3-AS1 overexpression in CSCC cells.
circulation_biomarker_diagnosis_ns	33986857	hsa-mir-22	Osteoporosis	3p expression was lower while MAPK14 expression was higher in the serum from patients with OP compared with healthy volunteers.
lncRNA target	33986850	hsa-mir-761	Colorectal Neoplasms	A functional study suggested that LINC01535 silencing inhibited CRC cell proliferation and invasion but enhanced cisplatin sensitivity of CRC cells, while co-transfection with a miR-761 inhibitor reversed these biological effects.
lncRNA target	33986849	hsa-mir-499	Myocardial Reperfusion Injury	In summary, IPostC protected the rat myocardium against I/R injury, by inhibiting local and systemic complement activation; inflammation; NF-kappaB signaling; and upregulation of miR-499.
target gene	33986848	hsa-mir-660	Liver Neoplasms	miR-660 promotes liver cancer cell proliferation by targeting PPP2R2A.
genetics_knock down_suppress	33986844	hsa-mir-107	Carcinoma, Non-Small-Cell Lung	HMGB1-knockdown inhibited the proliferation and enhanced the radiosensitivity of NSCLC cells, which may be regulated via miR-107 by mediating the TLR4/NF-kappaB signaling pathway.
circulation_biomarker_diagnosis_ns	33986829	hsa-mir-770	Diabetes Mellitus, Type 2	5p was highly expressed in the serum of patients with T2DM compared with healthy volunteers.
transcription factor target	33986822	hsa-mir-137	Brain Damage, Chronic	Electroacupuncture treatment attenuated brain injury in CCH model group via regulating miR-137/NOX4 axis. These results suggest that electroacupuncture therapy for CCH may be mediated by miR-137/NOX4 axis.
lncRNA target	33986803	hsa-mir-28	Lymphoma, Large B-Cell, Diffuse	In sum, our findings clearly indicate that TUC338 functions as an oncogenic lncRNA in DLBCL through activating EGFR/PI3K/AKT pathway via sponging and inhibiting miR
target gene	33986801	hsa-mir-1224	Breast Neoplasms	miR-1224-3p Promotes Breast Cancer Cell Proliferation and Migration through PGM5-Mediated Aerobic Glycolysis.
genetics_overexpression_suppress	33986660	hsa-mir-497	Retinoblastoma	miR-497 inhibitor or WEE1 overexpression dramatically reversed the effects of TRPM2-AS downregulating on the malignant phenotypes of RB cells.
lncRNA target	33986610	hsa-mir-1178	Thyroid Cancer, Papillary	CONCLUSION: BRCA2 rs15869 is characterized as a potential biomarker associated with PTC risk, highlighting the contribution of the hsa-miR3p via functional exploration.
other	33986456	hsa-mir-192	Metabolic Diseases	Additionally, miRNA 192 was significantly elevated in metabolically unhealthy obesity.
other	33986456	hsa-mir-34a	Metabolic Diseases	Several miRNA levels including miRNAs 34a, 93, 122, and 192 were statistically significantly differing between individuals with prediabetes, impaired glucose tolerance, metabolic syndrome, or nonalcoholic fatty liver disease compared to the respective controls.
other	33986456	hsa-mir-192	Obesity	Additionally, miRNA 192 was significantly elevated in metabolically unhealthy obesity.
other	33986456	hsa-mir-34a	Obesity	Several miRNA levels including miRNAs 34a, 93, 122, and 192 were statistically significantly differing between individuals with prediabetes, impaired glucose tolerance, metabolic syndrome, or nonalcoholic fatty liver disease compared to the respective controls.
other	33986358	hsa-mir-363	Urinary Bladder Diseases	A three urinary miRNA signature (miR-10a-5p, miR-301b-3p and miR3p) could discriminate between controls and patients with LUTD (BLUTD and NLUTD).
other	33986358	hsa-mir-10a	Urinary Bladder Diseases	A three urinary miRNA signature (miR-10a-5p, miR-301b-3p and miR3p) could discriminate between controls and patients with LUTD (BLUTD and NLUTD).
transcription factor target	33986262	hsa-mir-146a	Osteoarthritis	Our findings demonstrate, for the first time, that KGN exerts anti-arthritic effects via activation of the miR-146a-NRF2 axis and KGN is a promising heterocyclic molecule to prevent OA-induced cartilage degeneration.
transcription factor target	33986262	hsa-mir-146a	Cartilage Diseases	Our findings demonstrate, for the first time, that KGN exerts anti-arthritic effects via activation of the miR-146a-NRF2 axis and KGN is a promising heterocyclic molecule to prevent OA-induced cartilage degeneration.
genetics_knock down_promote	33986259	hsa-mir-8055	Cardiomyopathies	Knockdown of circACSL1 or overexpression of miR-8055 reduced myocardial inflammation and myocardial injury level and these effects were rescued by overexpression of MAPK14. In summary, our study demonstrated that circACSL1 could aggravate myocardial inflammation and myocardial injury through competitive absorption of miR-8055, thereby upregulating MAPK14 expression.
genetics_knock down_promote	33986259	hsa-mir-8055	Myocarditis	Knockdown of circACSL1 or overexpression of miR-8055 reduced myocardial inflammation and myocardial injury level and these effects were rescued by overexpression of MAPK14. In summary, our study demonstrated that circACSL1 could aggravate myocardial inflammation and myocardial injury through competitive absorption of miR-8055, thereby upregulating MAPK14 expression.
other	33985670	hsa-mir-122	Asphyxia	In a previous study, four biomarkers-dual-specificity phosphatase 1 (DUSP1), potassium voltage-gated channel subfamily J member 2 (KCNJ2), miR-122, and miRwere screened in human cardiac tissue from cadavers that died from mechanical asphyxia compared with those that died from craniocerebral injury, hemorrhagic shock, or other causes.
other	33985670	hsa-mir-185	Asphyxia	In a previous study, four biomarkers-dual-specificity phosphatase 1 (DUSP1), potassium voltage-gated channel subfamily J member 2 (KCNJ2), miR-122, and miRwere screened in human cardiac tissue from cadavers that died from mechanical asphyxia compared with those that died from craniocerebral injury, hemorrhagic shock, or other causes.
lncRNA target	33985638	hsa-mir-29a	Fatty Liver	MiR-29 a mimic and miR-29 a inhibitor were transfected into hepatocytes, and then established the human steatotic hepatocyte model, the result of oil red O staining and triglyceride(TG)lipid content were observed, the expression of Sirt1 mRNA and protein were detected by qRT-PCR and Western blotting, respectively.
other	33985567	hsa-mir-424	Cardiovascular Diseases	5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM.
other	33985567	hsa-mir-424	Diabetes Mellitus, Type 1	5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM.
epigenetics	33985545	hsa-mir-106b	Carcinoma, Hepatocellular	Mechanistic analysis revealed that circMEMO1 can modulate the promoter methylation and gene expression of TCF21 to regulate HCC progression by acting as a sponge for miR-106b-5p, which targets the TET family of genes and increases the 5hmC level.
lncRNA target	33985523	hsa-mir-155	Neurogenic Inflammation	coli infection induced miR-155 and miR-146a, which collectively regulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappaB and EGFR-NF-kappaB signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage.
lncRNA target	33985523	hsa-mir-146a	Neurogenic Inflammation	coli infection induced miR-155 and miR-146a, which collectively regulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappaB and EGFR-NF-kappaB signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage.
genetics_overexpression_promote	33985519	hsa-mir-1303	Leukemia, Myeloid, Acute	Furthermore, the effect of TPTEP1 overexpression on AML cell proliferation was counteracted under miR-1303 upregulation.
other	33984967	hsa-mir-92b	Small Cell Lung Carcinoma	To test the relationship of membrane fluidity and invasiveness, we first demonstrated that transfection of small RNA miR-92b-3p can significantly increase invasiveness of the small cell lung cancer cell line SHP77.
other	33984882	hsa-mir-1301	Colorectal Neoplasms	In the present study, we identified miR-1301 was enriched in normal colorectal tissues and significantly down-regulated in CRC. In summary, this study highlights the significant role of miR-1301/STAT3 axis in CRC metastasis.
lncRNA target	33984721	hsa-mir-211	Endometritis	This study aims to investigate the regulatory role of miR-211 in the innate immune response involved in endometritis, and to evaluate its potential therapeutic value. Therefore, miR-211 has anti-inflammatory effects and mediates the negative regulation of the NF-kappaB signaling pathway in LPS-induced endometritis by targeting TAB1.
transcription factor target	33984719	hsa-mir-497	Corneal Neovascularization	Mechanically, miR-497 might serve as a potential strategy for pathological corneal neovascularization via macrophage through the IL-6/STAT3/VEGFA signaling pathway.
genetics_GWAS	33984485	hsa-mir-26a	Inflammation	The knockdown of miR-26a ubiquitously resulted in a significant reduction of miR-26a in embryos, accompanied by impaired TnP immunomodulatory function observed by the loss of the control of the removal of neutrophils in response to inflammation, while the overexpression increased the inhibition of neutrophilic inflammation promoted by TnP.
transcription factor target	33984358	hsa-mir-145	Inflammatory Bowel Diseases	The downregulation of miR-145 reduced the drug sensitivity of 5-aminosalicylic acid (5-ASA) and glucocorticoids in treating UC, indicating that miR-145 might be a potential therapeutic target for UC.
lncRNA target	33983643	hsa-mir-19a	Colonic Neoplasms	Our findings showed that lncRNA CASC2 inhibited cell viability in colon cancer cell lines and miR-19a reversed its functions through the NF-kappaB signalling pathway, suggesting that these could be factors in treating colon cancer in the future.
other	33982889	hsa-mir-10b	Lupus Erythematosus, Systemic	Importantly, hsa-miR-10b-5p expression levels were elevated in T cells from healthy women compared to healthy men and also elevated in T cells from SLE patients.
genetics_overexpression_promote	33982790	hsa-mir-454	Breast Neoplasms	Overexpression of miR4545p promoted breast cancer cell viability, migration and invasion in vitro, whereas silencing of miR4545p inhibited breast cancer proliferation, migration and invasion in vitro and suppressed tumor growth in vivo.
transcription factor target	33982786	hsa-mir-29b	Nasal Polyps	In the present study, samples from 100 patients with CRSwNPs were examined via reverse transcriptionquantitative PCR to assess the mRNA expression of miR29b3p, and western blotting was performed to assess the protein expression of MMP2, MMP9, acetylalphatubulin, integrin beta1 and tissue inhibitor of metalloproteinase 1 (TIMP1).
genetics_overexpression_promote	33982777	hsa-mir-500a	Stomach Neoplasms	lncRNA NEAT1 overexpressionmediated inhibition of gastric cancer cell proliferation and invasion was significantly reversed by miR500a3p overexpression. The present study demonstrated that lncRNA NEAT1 inhibited gastric cancer cell proliferation and invasion, and promoted apoptosis by regulating the miR500a3p/XBP1 axis.
transcription factor target	33982775	hsa-mir-133b	Cardiomyopathies	Thus, the current results indicated that miR133b alleviated doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2, implying that miR133b may be a potential biomarker for doxorubicininduced cardiac injury.
other	33982771	hsa-mir-23a	Sepsis	The expression of miR23a3p was downregulated whereas that of TLR4 was upregulated in the septic cells.
genetics_overexpression_promote	33982769	hsa-mir-198	Squamous Cell Carcinoma of Head and Neck	In addition, transfection of small interfering RNA against CDK4 in OSCC cells showed similar inhibitory effects on cell proliferation, invasion and EMT, whereas CDK4 overexpression in OSCC cells partially reversed the inhibitory effects of the miR198 mimic.
genetics_knock down_promote	33982765	hsa-mir-635	Osteosarcoma	Notably, mechanistic investigation revealed that lncRNA DUXAP8 predominantly acted as a competing endogenous RNA in OS by regulating the miR635/topoisomerase alpha 2 (TOP2A) axis. lncRNA DUXAP8 is upregulated in OS, and lncRNA DUXAP8knockdown serves a vital antitumor role in OS cell progression through the miR635/TOP2A axis.
lncRNA target	33982764	hsa-mir-24	Glioma	Collectively, the present findings demonstrated that NEAT1 acted as a competing endogenous RNA for miR3245p, and identified the NEAT1/miR3245p/KCTD20 axis as a novel regulatory axis and a potential therapeutic target for human glioma.
exosome	33982667	hsa-mir-127	Glioma	CONCLUSION: These results demonstrated that exosomal circRNA 0001445 promoted glioma progression through miRNA5p/SNX5 signaling pathway.
circulation_biomarker_diagnosis_ns	33982582	hsa-mir-215	Colorectal Neoplasms	However, circulating mmu-miR
other	33982450	hsa-mir-210	Osteoporosis	3p showed to be increased.
circRNA target	33982351	hsa-mir-149	Liver Cirrhosis	"Together, circUbe2k may act as a ""catalyst"" of HSCs activation and HF through the circUbe2k/miR5p/TGF-beta2 axis."
circRNA target	33982329	hsa-mir-24	Carcinoma, Hepatocellular	CONCLUSION: This study suggested GL63 impeded the HCC development by blocking the JAK2/STAT3 signaling pathway via mediating the circZNF83/miR
circulation_biomarker_diagnosis_up	33982217	hsa-mir-532	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33982217	hsa-let-7b	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33982217	hsa-mir-26b	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33982217	hsa-mir-221	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33982217	hsa-mir-5589	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33982217	hsa-mir-184	Carcinoma, Hepatocellular	RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR
circulation_biomarker_diagnosis_up	33981849	hsa-mir-107	Atherosclerosis	Expression of circ_UBR4 and ROCK1 was upregulated, whereas miR-107 was downregulated in human AS serum and ox-LDL-induced VSMCs. circ_UBR4 might be a contributor in human AS partially by regulating VSMCs' cell proliferation, migration, and cell cycle progression via circ_UBR4/miR-107/ROCK1 pathway.
lncRNA target	33981845	hsa-mir-320c	Osteoarthritis	In this study, levels of TUG1 and FUT4 were distinctly upregulated, but miR-320c level significantly decreased in OA tissues and chondrocytes derived from OA tissues as well as in IL-1beta-stimulated C28/I2 cells. Collectively, TUG1 modulated cell proliferation, apoptosis and ECM degradation in IL-1beta-induced C28/I2 cells via the miR-320c/FUT4 axis, providing a new insight into the OA treatment.
lncRNA target	33981772	hsa-mir-137	Osteosarcoma	circPVT1 and TRIAP1 were highly expressed, and miR-137 was decreased in DXR-resistant osteosarcoma tissues and cells. circPVT1 boosted DXR resistance of osteosarcoma cells partly by regulating the miR-137/TRIAP1 axis, hinting a promising therapeutic target for the osteosarcoma treatment.
transcription factor target	33981730	hsa-mir-205	Atrial Fibrillation	Conclusion: The miR-205/P4HA3 axis is implicated in atrial fibrosis by inhibition of rat fibroblast proliferation and migration and the inactivation of JNK signaling pathway.
transcription factor target	33981730	hsa-mir-205	Fibrosis, Atrial	Conclusion: The miR-205/P4HA3 axis is implicated in atrial fibrosis by inhibition of rat fibroblast proliferation and migration and the inactivation of JNK signaling pathway.
lncRNA target	33981611	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	In conclusion, we demonstrated that circ_0032822 functions as a tumor oncogene in HNSCC and that its function is regulated via the miR-141/E2F3 axis.
genetics_overexpression_promote	33981482	hsa-mir-410	Atherosclerosis	Furthermore, silencing miR-410 or overexpressing HDAC1 increased cell viability and suppressed apoptosis and an inflammatory reaction in HUVECs in atherosclerosis.
other	33981362	hsa-mir-1179	Breast Neoplasms	Long non-coding RNA TMPO-AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR-1179/TRIM37 axis.
genetics_knock down_suppress	33981357	hsa-mir-182	Melanoma	The overexpression of NUPR1 reversed the effects of DUXAP8 knockdown or miR-3182 mimic on melanoma progression. In conclusion, lncRNA DUXAP8 downregulation inhibits the development of melanoma by regulating the miR-3182/NUPR1 axis.
transcription factor target	33981308	hsa-mir-155	psoriasis 1	As the direct binding of tnfaip3 to miR-155 has been demonstrated by luciferase reporter assay, and Ebosin has been demonstrated to inhibit miR-155 level in vitro and in vivo, our study first indicates that Ebosin reduces inflammation through the miRtnfaip3-IL-17 axis and T cell differentiation in a psoriasis-like model.
target gene	33981163	hsa-mir-139	Carcinoma, Non-Small-Cell Lung	MiR-139-5p Targetedly Regulates YAF2 and Mediates the AKT/P38 MAPK Signaling Pathway to Alleviate the Metastasis of Non-Small Cell Lung Cancer Cells and Their Resistance Against Cisplatin.
genetics_overexpression_promote	33981162	hsa-mir-34a	Leukemia, Myeloid, Acute	In AML cells, overexpression of circ_POLA2 decreased the expression levels of mature miR-34a, but not miR-34a precursor.
transcription factor target	33980925	hsa-mir-506	Cholangitis, Sclerosing, Primary	MiR-506 was substantially upregulated in ascending colons of PSC and PSC UC patients, in contrast to sigmoid colons of PSC and UC patients. In ascending colons with PSC UC, upregulation of miR-506 may result in failure of bicarbonate secretion and inhibition of p53, which predisposes to pro-tumorigenic transformation.
transcription factor target	33980925	hsa-mir-506	Inflammatory Bowel Diseases	MiR-506 was substantially upregulated in ascending colons of PSC and PSC UC patients, in contrast to sigmoid colons of PSC and UC patients. In ascending colons with PSC UC, upregulation of miR-506 may result in failure of bicarbonate secretion and inhibition of p53, which predisposes to pro-tumorigenic transformation.
other	33980826	hsa-mir-125a	Melanoma	Moreover, we identified hsa-miR-125a-5p|0|-2 isoform as tenfold over-represented in melanoma than the canonical form and differentially expressed in MPMs arising in the same patient.
genetics_knock down_suppress	33980772	hsa-mir-879	Inflammation	Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR
genetics_knock down_suppress	33980772	hsa-mir-879	Diabetic Nephropathies	Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR
genetics_overexpression_promote	33980319	hsa-mir-182	Asthma	In addition, in vivo overexpression of EGR2 countered the promoting effect of the YAP/HIF-1alpha/miR-182 axis on asthma and lipid metabolism dysfunction.
circulation_biomarker_diagnosis_up	33980140	hsa-mir-15a	Sepsis	METHODS: Expression of circFADS2, mature miR-15a-5p, and miR-15a-5p precursor in plasma samples from sepsis patients and healthy controls was determined by RT-qPCR.
circRNA target	33979737	hsa-mir-513a	Stomach Neoplasms	circBFAR was proven to promote GC proliferation by targeting the miR-513a-3p/hexokinase 2 (HK2) axis. In this study, we found a circBFAR/miR-513a-3p/HK2 axis in GC and revealed the relationship between circBFAR and glycolysis for the first time.
genetics_overexpression_suppress	33979697	hsa-mir-148a	Alzheimer Disease	Overexpression of miR-148a-3p attenuated Abeta induced neurotoxicity in AD by targeting ROCK1.
lncRNA target	33979576	hsa-mir-132	Autoimmune Diseases	More importantly, miR-132 inhibits LPS-induced NF-kappaB signaling pathway by targeting IL-1beta, thereby preventing excessive inflammatory response from causing autoimmune diseases.
other	33979314	hsa-mir-210	Primary Graft Dysfunction	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
other	33979314	hsa-mir-34a	Hepatitis C	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
other	33979314	hsa-mir-34a	Primary Graft Dysfunction	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
other	33979314	hsa-mir-122	Primary Graft Dysfunction	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
other	33979314	hsa-mir-210	Hepatitis C	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
other	33979314	hsa-mir-122	Hepatitis C	A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis.
circulation_biomarker_diagnosis_ns	33978942	hsa-mir-146b	Pneumonia	In conclusion, the relative expression of miR-146b in serum of infantile pneumonia decreased, and over-expressing it could promote LPS-induced cell viability and reduce apoptosis.
lncRNA target	33978928	hsa-mir-16	Sepsis	Collectively, it is concluded that XIST reduces sepsis-induced ALI via regulating miR
lncRNA target	33978928	hsa-mir-16	Lung Injury	Collectively, it is concluded that XIST reduces sepsis-induced ALI via regulating miR
lncRNA target	33978765	hsa-mir-145	Diabetes Mellitus	Silencing circANKRD36 alleviated the inflammation and suppressed cell apoptosis in the pancreatic tissues of T2DM rats, which was abated by miR-145 inhibitor. Additionally, miR-145 inhibitor increased the level of XBP1 in T2DM rats, which was decreased in the presence of circANKRD36 silencing.
lncRNA target	33978765	hsa-mir-145	Inflammation	Silencing circANKRD36 alleviated the inflammation and suppressed cell apoptosis in the pancreatic tissues of T2DM rats, which was abated by miR-145 inhibitor. Additionally, miR-145 inhibitor increased the level of XBP1 in T2DM rats, which was decreased in the presence of circANKRD36 silencing.
circRNA target	33978716	hsa-mir-195	Prostatic Neoplasms	Overall, our study demonstrated that hsa_circ_0062019 promoted PCa cell proliferation, migration, and invasion via upregulation of HMGA2 expression by sponging miR5p.
circulation_biomarker_prognosis_ns	33978382	hsa-mir-182	Intervertebral Disc Degeneration	RESULTS: The expression level of miR-182 was dramatically increased in plasma samples of IDD patients compared with the controls.
circulation_biomarker_diagnosis_up	33978365	hsa-mir-429	Diabetes, Gestational	CONCLUSIONS: In summary, the increase of serum and urine miR-429 level is a risk factor of insulin resistance in pregnant women with GDM.
lncRNA target	33978322	hsa-mir-29c	Multiple Sclerosis	Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs.
lncRNA target	33978322	hsa-mir-25	Multiple Sclerosis	Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs.
lncRNA target	33978322	hsa-mir-20a	Multiple Sclerosis	Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs.
genetics_GWAS	33978320	hsa-mir-3130	Adenocarcinoma of Lung	5p as an intermediate modulator of risk loci 2q33 and the tumor suppressor NDUFS1.
circulation_biomarker_prognosis_ns	33978071	hsa-mir-215	Stomach Neoplasms	Furthermore, serum EV-miR
genetics_knock down_promote	33977869	hsa-mir-141	Cicatrix, Hypertrophic	INHBA-AS1-knockdown suppresses the formation of HS by regulating miR
genetics_overexpression_promote	33977112	hsa-mir-34a	Liver Cirrhosis	RESULTS: We found that miR-34a was overexpressed in the peripheral blood in PBC patients.
genetics_overexpression_promote	33977112	hsa-mir-34a	Cholangitis, Biliary, Primary	RESULTS: We found that miR-34a was overexpressed in the peripheral blood in PBC patients.
circulation_biomarker_diagnosis_up	33976977	hsa-mir-23b	Osteoporosis	RESULTS: Decreased expression of TUG1 and increased expression of miR-23b evident in the plasma of patients with osteoporosis than in that of age- and sex-matched healthy controls.
target gene	33976749	hsa-mir-515	Thyroid Neoplasms	ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3.
lncRNA target	33976745	hsa-mir-1224	Glioma	Conclusion: Together, our results revealed that circ-ZNF609 elevates glioma growth and metastasis via enforcing PLK1 expression by competitively binding miR
circRNA target	33976734	hsa-mir-1243	Glioma	5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma.
lncRNA target	33976730	hsa-mir-193b	Stomach Neoplasms	To sum up, these experimental results demonstrated that BLACAT2 acted as an oncogene in gastric cancer progression through the regulation of the miR-193b-5p/METTL3 pathway, hence providing new insights regarding the pathogenesis of gastric cancer.
transcription factor target	33976725	hsa-mir-202	Colorectal Neoplasms	5p resulted in CRC cell proliferation inhibition and enhancement, respectively.
exosome	33976535	hsa-mir-1182	Prostatic Neoplasms	RESULTS: Circ-XIAP and TPD52 were upregulated and miR-1182 was downregulated in DTX-resistant PCa tissue specimens and cell lines. CONCLUSION: Exosomal circ-XIAP promoted DTX resistance of PCa by regulating miR-1182/TPD52 axis, providing a promising therapeutic target for PCa chemotherapy.
exosome	33976355	hsa-mir-21	Rett Syndrome	In the present study, we sought to determine whether that exosomal miR5p from USCs could promote early neural formation in a model of RTT.
lncRNA target	33976115	hsa-mir-124	Esophageal Squamous Cell Carcinoma	Taken together, we identified that CircRNA_2646 functioned as an inhibitor in miR-124 signaling pathway in ESCC for carcinogenesis and could be a promising target for ESCC therapy.
exosome	33975615	hsa-mir-1252	Glioma	CONCLUSION: Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR5p-mediated degradation and demethylation in glioma.
genetics_knock down_promote	33975612	hsa-mir-127	Osteoarthritis	CONCLUSION: Circ_0128846 knockdown might inhibit the progression of OA by upregulating miR
lncRNA target	33975517	hsa-mir-16	Stomach Neoplasms	5p, resulting in the recovery of the Hippo pathway, which suppressed the expression levels of the downstream oncogenes, including EGFR, SOX2 and OCT4, leading to the inhibition of the malignant phenotypes in GC cells.
other	33975327	hsa-mir-432	Reperfusion Injury, Renal Ischemia	3p) affects inflammation in both RI-RI rats and NRK52E cells.
other	33975264	hsa-mir-516b	MASA syndrome	RNA Sequencing showed microRNA (miR) miR-516b-5p, was present at significantly lower levels in L/PT-DMSCs.
lncRNA target	33975060	hsa-mir-548s	Pancreatic Carcinoma	RESULTS: We identified the CAV1-CAV2 locus tagged by rs8940 was significantly associated with PDAC prognosis, and rs10249656 in the 3'untranslated region of CAV2 was the real functional variant, which upregulated CAV2 expression through abolishing miR-548s binding.
circulation_biomarker_prognosis_ns	33974530	hsa-mir-9	Carotid Stenosis	Serum miR
lncRNA target	33974352	hsa-mir-22	Stomach Neoplasms	Overall, NCK1-AS1 functions as an oncogene and promotes gastric cancer progression via the miR3p/BCL9-Wnt/beta-catenin signaling pathway.
other	33974163	hsa-mir-142	Ovarian Neoplasms	5p/PD-L1 axis is involved in regulating OC progression.
circRNA target	33973871	hsa-mir-96	Fibrosis, Renal	5p/HBEGF/KRAS axis and suggest that circRNA_30032 is a potential therapeutic target for treatment of renal fibrosis.
other	33973644	hsa-mir-486	Carcinoma, Squamous Cell	5p expression profiles.
other	33973644	hsa-mir-126	Carcinoma, Squamous Cell	5p expression profiles.
other	33973644	hsa-mir-182	Carcinoma, Squamous Cell	The aim of this study was to analyze mir-126, mir-182, and mir5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles.
other	33973497	hsa-mir-199a	Ventricular Premature Complexes	Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.
other	33973497	hsa-mir-125b	Ventricular Premature Complexes	Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.
other	33973497	hsa-mir-195	Ventricular Premature Complexes	Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.
other	33973497	hsa-mir-222	Ventricular Premature Complexes	Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.
transcription factor target	33973278	hsa-mir-4286	Osteoporosis	CONCLUSIONS: We firstly demonstrated that miR-4286 might function via intimate osteogenesis-angiogenesis pathway to alleviate alcohol-induced osteopenia via targeting HDAC3.
transcription factor target	33973278	hsa-mir-4286	Alcoholism	CONCLUSIONS: We firstly demonstrated that miR-4286 might function via intimate osteogenesis-angiogenesis pathway to alleviate alcohol-induced osteopenia via targeting HDAC3.
other	33973132	hsa-mir-454	DiGeorge Syndrome	The expressions of miR3p, lncRNA-DiGeorge syndrome critical region gene 5 (DGCR5) and growth arrest and DNA damage protein-inducible 45A (GADD45A) in placental tissues from PE patients or HTR-8/SVneo cells were assessed by Western blot or qRT-PCR.
lncRNA target	33973132	hsa-mir-454	Pneumonia, Mycoplasma	3p increased viability and promoted migration, invasion and tube formation in HTR-8/SVneo cells while inhibiting apoptosis.
genetics_overexpression_promote	33972506	hsa-mir-296	Lung Neoplasms	Inhibited AGAP2-AS1, macrophage-derived exosomes, and exosomes overexpressing AGAP2-AS1 or inhibiting miR-296 facilitated the malignant phenotypes of radioresistant lung cancer cells.
transcription factor target	33972468	hsa-mir-20b	Ischemic Stroke, Cerebral	Our study demonstrated that upregulation of miR-20b protected the brain from ischemic brain injury by targeting TXNIP, extending our understanding of miRNAs in cerebral ischemic stroke.
transcription factor target	33971623	hsa-mir-205	Breast Neoplasms	These results collectively indicated the tumor-suppressive role of miR-205 in breast cancer by targeting CLDN11; implying miR-205 may serve as a novel therapeutic target for breast cancer.
genetics_overexpression_promote	33971546	hsa-mir-133b	Adenocarcinoma of Lung	The results of in vitro functional experiments showed that overexpression of CDCA8 could promote the proliferation, invasion, and migration of LUAD cells, and miR-133b could reverse this promotion by targeting CDCA8.
circRNA target	33971492	hsa-mir-153	Osteoarthritis	CONCLUSION: Taken together, the results in this study suggested that circATRNL1 might ameliorate the development and progression of OA through regulating miR3p/KLF5 axis.
exosome	33971282	hsa-mir-338	Pancreatic Carcinoma	Overall, BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR
other	33970852	hsa-mir-16-1	Squamous Cell Carcinoma of Head and Neck	1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis.
other	33970852	hsa-mir-16	Squamous Cell Carcinoma of Head and Neck	1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis.
other	33970852	hsa-mir-15a	Squamous Cell Carcinoma of Head and Neck	1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis.
genetics_knock down_suppress	33969901	hsa-mir-5195	Leukemia, Myeloid, Acute	Meanwhile, the role of circ_0009910 knockdown in AML cells was partially reversed by miR
circulation_biomarker_diagnosis_up	33969722	hsa-mir-210	Colorectal Neoplasms	3p in circulating plasma exosomes was markedly upregulated in colorectal cancer patients, which were closely associated with multiple unfavorable clinicopathological features.
lncRNA target	33969374	hsa-mir-613	Leukemia	In conclusion, UCA1 up-regulation facilitated the resistance of acute leukemia cells to DNR via the PI3K/AKT pathway by sponging miR-613.
lncRNA target	33969134	hsa-mir-374	Colorectal Neoplasms	Hsa-miR-374 might be as a helpful biomarker or therapeutic target in CRC.
lncRNA target	33969134	hsa-mir-374a	Colorectal Neoplasms	Hsa-miR-374 might be as a helpful biomarker or therapeutic target in CRC.
genetics_GWAS	33969131	hsa-mir-612	Precursor Cell Lymphoblastic Leukemia-Lymphoma	A previous study suggested that mir-612 rs12803915 G> A may be associated with pediatric ALL risk. CONCLUSION: HRM is a suitable method to detect SNP rs12803915 in the mir-612 gene; however, we found no significant association between the rs12803915 polymorphism and ALL risk.
lncRNA target	33969128	hsa-mir-106b	Carcinoma, Renal Cell	Conclusively, circ-ITCH suppresses ccRCC metastasis by enforcing PDCD4 expression through binding miR-106b-5p.
transcription factor target	33969024	hsa-mir-200a	Heart Diseases	Interestingly, miR-200a-3p inhibition in activated FBs, alleviated TGF-beta1-FB-Exo-mediated endothelial dysfunction.
target gene	33968986	hsa-mir-210	Pancreatic Neoplasms	Long Non-coding RNA DLEU2L Targets miR-210-3p to Suppress Gemcitabine Resistance in Pancreatic Cancer Cells via BRCA2 Regulation.
genetics_knock down_promote	33968966	hsa-mir-147a	Carcinoma, Non-Small-Cell Lung	Mechanically, miR-147a/IFITM1 axis was a downstream target of LINC00847, and silencing of miR-147a could rescue the anti-cancer effects of LINC00847 knockdown on NSCLC cell behaviors. Conclusion: Overall, up regulation of LINC00847 induced by E2F1 promoted the progression of NSCLC by modulating miR-147a/IFITM1 axis, representing a novel regulatory mechanism for NSCLC progression.
circRNA target	33968929	hsa-mir-411	Osteosarcoma	Briefly, circSIPA1L1 could function as a driver gene in OS and initiate OS tumorigenesis through the miR5p/RAB9A signaling pathway, which might become a potential therapeutic biomarker for OS treatment.
lncRNA target	33968923	hsa-mir-146a	Amyotrophic Lateral Sclerosis	These results propose miR-146a as a new causal and emerging therapeutic target for astrocyte pathogenic processes in ALS.
transcription factor target	33968853	hsa-mir-24	Nephrosis, Lipoid	There were lower levels of miR-24 and miR-27 in children with active non-atopic INS (P < 0.05). miR-24 and miR-27 suppressed the expression of Th2 cells and have a critical function regulating Th2 cell expression in INS.
transcription factor target	33968853	hsa-mir-27	Nephrosis, Lipoid	There were lower levels of miR-24 and miR-27 in children with active non-atopic INS (P < 0.05). miR-24 and miR-27 suppressed the expression of Th2 cells and have a critical function regulating Th2 cell expression in INS.
genetics_overexpression_promote	33968785	hsa-mir-346	Carcinoma, Non-Small-Cell Lung	Dual-luciferase reporter assays were also carried out to reveal the interaction between miR-346 and the 3' untranslated region (3'UTR) of adenomatous polyposis coli (APC) mRNA.Our data demonstrated that overexpression of lncRNA GHRLOS suppressed cancer cell proliferation and invasion as well as promoted cell apoptosis by regulating the expression of CDK2, PCNA, E-cadherin, N-cadherin, Bax, and Bcl-2 in NSCLC cells. In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC.
genetics_knock down_promote	33968763	hsa-mir-137	Squamous Cell Carcinoma of Head and Neck	3p expression rescued the suppressive behaviors of LINC01929 knockdown on the biological behaviors of OSCC cells.
target gene	33968726	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	Long Noncoding RNA MLK7-AS1 Promotes Non-Small-Cell Lung Cancer Migration and Invasion via the miR-375-3p/YWHAZ Axis.
lncRNA target	33968711	hsa-mir-451a	Colonic Neoplasms	RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification.
lncRNA target	33968711	hsa-mir-4299	Colonic Neoplasms	RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification.
lncRNA target	33968711	hsa-mir-654	Colonic Neoplasms	RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification.
lncRNA target	33968711	hsa-mir-575	Colonic Neoplasms	RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification.
target gene	33968662	hsa-mir-335	Urinary Bladder Neoplasms	LncRNA DANCR regulates lymphatic metastasis of bladder cancer via the miR-335/VEGF-C axis.
other	33968653	hsa-mir-371a	Fibrosis	Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy.
other	33968653	hsa-mir-371a	Teratoma	Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy.
other	33968653	hsa-mir-375	Teratoma	Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy.
other	33968653	hsa-mir-375	Fibrosis	Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy.
other	33968586	hsa-mir-210	Fibrosis	Taken together, the present study suggests that TGFbeta-induced miR5p reduced STAT5A expression, leading to aberrant activation of STAT3, and facilitate skin fibrosis in HDFs.
circulation_biomarker_diagnosis_ns	33968296	hsa-mir-501	Instent Restenosis	Collectively, these findings showed that plasma sEV-carried miRNA
other	33968210	hsa-mir-665	Stomach Neoplasms	MicroRNA-665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3.
genetics_knock down_promote	33968209	hsa-mir-98	Nasopharyngeal Carcinoma	Furthermore, miR-98 inhibition counteracted the inductive effect of HOXA11-AS-knockdown on the DDP sensitivity of NPC cells.
target gene	33968202	hsa-mir-1244	Prostatic Neoplasms	Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR-1244/MAP3K2 axis.
target gene	33968198	hsa-mir-204	Lung Neoplasms	MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells.
target gene	33968197	hsa-mir-188	Colonic Neoplasms	miR-188-5p promotes oxaliplatin resistance by targeting RASA1 in colon cancer cells.
target gene	33968189	hsa-mir-219a	Thyroid Neoplasms	MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway.
other	33968182	hsa-mir-221	Thyroid Neoplasms	miR-221-3p and miR-222-3p regulate the SOCS3/STAT3 signaling pathway to downregulate the expression of NIS and reduce radiosensitivity in thyroid cancer.
other	33968182	hsa-mir-222	Thyroid Neoplasms	miR-221-3p and miR-222-3p regulate the SOCS3/STAT3 signaling pathway to downregulate the expression of NIS and reduce radiosensitivity in thyroid cancer.
genetics_knock down_suppress	33968176	hsa-mir-155	Osteosarcoma	Knockdown of NORAD and transfection of miR
exosome	33968135	hsa-mir-20a	Acute-On-Chronic Liver Failure	Altogether, our data suggest that the exosomal miR-20a-5p/intracellular CXCL8 axis may play an important role in the reduction of liver inflammation in ACLF in the context of MSC-based therapies and highlights CXCL8 as a potential target for alleviating liver injury.
other	33967958	hsa-mir-21	Renal Tubule Ischemia	Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia.
other	33967958	hsa-mir-21	Retinitis	Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia.
other	33967958	hsa-mir-21	Acute Lung Injury	Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia.
other	33967607	hsa-mir-29a	Diabetes Mellitus, Type 2	The function prediction results showed that has_circ_0071106 was involved in biological processes such as protein binding, gene transcription, and may be involved in the pathway of hsa-miR-29a-5p regulating diabetes, has_circ_0071106 may be used as a diagnostic marker for T2DM.
circulation_biomarker_diagnosis_up	33966404	hsa-mir-181a	Cicatrix, Hypertrophic	METHODS HSFb cells were transfected with miR-negative control (miR-NC), miR-181a mimics, miR-181a inhibitor, pcDNA3.1-PTEN (pc-PTEN), or small interfence-PTEN (si-PTEN) plasmid using a Lipofectamine 2000 transfection kit.
genetics_knock down_suppress	33966370	hsa-mir-19a	Lung Injury	This study aimed to investigate the role of miR-19a-3p and its regulation mechanism in sepsis-induced lung injury. In conclusion, miR-19a-3p knockdown could alleviate sepsis-induced lung injury through enhancing USP13 expression.
genetics_knock down_suppress	33966370	hsa-mir-19a	Sepsis	This study aimed to investigate the role of miR-19a-3p and its regulation mechanism in sepsis-induced lung injury. In conclusion, miR-19a-3p knockdown could alleviate sepsis-induced lung injury through enhancing USP13 expression.
other	33966214	hsa-mir-203a	Acidosis	In NCI-H358 lung cancer cells, miR-203a expression was repressed by acidosis.
lncRNA target	33966211	hsa-mir-203	Acidosis	Since acidosis modulates the expression of different microRNAs (e.g., miR-7, miR-183, miR-203, miR-215), microRNAs and their targets might be mediators between tumor acidosis and malignant behavior.
lncRNA target	33966211	hsa-mir-215	Acidosis	Since acidosis modulates the expression of different microRNAs (e.g., miR-7, miR-183, miR-203, miR-215), microRNAs and their targets might be mediators between tumor acidosis and malignant behavior.
lncRNA target	33965964	hsa-mir-182	Reperfusion Injury	By using miR-182 antagomir, the I/R injury was markedly ameliorated. CONCLUSIONS: Our results demonstrate that miR-182 promotes cell apoptosis and I/R injury through directly binding to FoxO3.
lncRNA target	33965958	hsa-mir-149	Uterine Cervical Neoplasms	CONCLUSION: ARAP1-AS1 was abnormally upregulated in CC tissues and indirectly modulated the POU2F2 expression via reducing miR
other	33965787	hsa-mir-29a	Stomach Neoplasms	In brief, we confirmed that circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway.
genetics_knock down_suppress	33965771	hsa-mir-206	Angelman Syndrome	CONCLUSION: MIAT knockdown impaired ox-LDL-induced HUVEC injury via regulating miR-206/RAB22A axis, suggesting the potential impacts of MIAT on AS occurrence, which revealed a potential therapeutic strategy for future clinic intervention in AS.
other	33965507	hsa-mir-204	Trichohepatoenteric Syndrome	In our previous study, we found that miR-204 was highly expressed in the ileum tissues of the susceptible group diarrhea piglets after infection with Clostridium perfringens (C.
lncRNA target	33964939	hsa-mir-129	Arthritis, Rheumatoid	5p was found to directly target HIPK2, and suppressed the tumor-like biologic behaviors and inflammation of RA-FLSs via regulating HIPK2.
transcription factor target	33964876	hsa-mir-128	Coronary Disease	3p had higher degrees, CTSB/CTSD could be targeted by them.
transcription factor target	33964876	hsa-mir-24	Coronary Disease	3p had higher degrees, CTSB/CTSD could be targeted by them.
other	33964458	hsa-mir-166	Genetic Diseases, Inborn	Under cold growing conditions, SlHB15A is subjected to conditional haploinsufficiency and recessive dosage sensitivity controlled by microRNA 166 (miR166).
transcription factor target	33964297	hsa-mir-19b	Carcinoma, Non-Small-Cell Lung	SIGNIFICANCE: In conclusion, this study demonstrates that MYPT1, regulated by miR-19b-3p, inhibits the progression of NSCLC via inhibiting the activation of wnt/beta-catenin signaling.
genetics_overexpression_promote	33964276	hsa-mir-1	Yellow Nail Syndrome	Here, we investigated the role of miR-1 overexpression in the development and function of sinoatrial (SAN) cells using murine embryonic stem cells (mESC).
other	33964276	hsa-mir-1	Heart Diseases	Conditions affecting the heart rate, such as endurance training and cardiac diseases, show a concomitant miR-1 up- or down-regulation.
lncRNA target	33963706	hsa-mir-23a	Osteoarthritis	OBJECTIVE: XFC can reduce the inflammatory response in patients with OA by down-regulating the expression of miR-23a-3p, inhibiting the activation of the PTEN/PI3K/AKT/ mTOR pathway, and regulating the expression of IL-1beta, IL-6, IL-10 and TNF-alpha.
genetics_knock down_suppress	33962944	hsa-mir-210	Inflammation	MiR-210 knockout in the hematopoietic lineage or in monocytes/macrophages mitigated the symptoms of endotoxemia, bacteremia, sepsis, and parasitosis, limiting the cytokine storm, organ damage/dysfunction, pathogen spreading, and lethality.
genetics_knock down_promote	33962657	hsa-mir-455	Thyroid cancer, medullary	Knockdown of circPVT1 or miR
genetics_knock down_promote	33962616	hsa-mir-578	Osteosarcoma	CONCLUSION: Circ-CNST knockdown could antagonize malignant behaviors and glycolysis of OS cells by regulating miR
lncRNA target	33962397	hsa-mir-34a	Glioma	Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma.
circulation_biomarker_diagnosis_up	33962174	hsa-mir-362	Breast Neoplasms	RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR
circulation_biomarker_diagnosis_up	33962174	hsa-mir-106b	Breast Neoplasms	RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR
circulation_biomarker_diagnosis_up	33962174	hsa-mir-142	Breast Neoplasms	RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR
circulation_biomarker_diagnosis_up	33962174	hsa-mir-26b	Breast Neoplasms	RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR
circulation_biomarker_diagnosis_up	33962174	hsa-mir-185	Breast Neoplasms	RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR
exosome	33961985	hsa-mir-21	Pulmonary Fibrosis	In conclusion, the results reveal that, in CS-induced pulmonary fibrosis, circRNA_0026344, via exosomal miR-21 regulation of Smad7, is involved in aberrant cross-talk of epithelium-fibroblasts.
other	33961875	hsa-mir-200	Diabetes Mellitus	The microRNA (miR)-200 family, specifically miR-141, is differentially expressed in diseased states including cognitive decline, thereby triggering changes in downstream genes.
lncRNA target	33961855	hsa-mir-495	Colorectal Neoplasms	SIGNIFICANCE: UCA1-miRSP1/SP3 axis is dysregulated in CRC and contributed to malignant phenotypes of CRC.
transcription factor target	33961841	hsa-mir-199a	Acute Lung Injury	SIGNIFICANCE: These findings reveal that irisin can alleviate ALI by inhibiting miR-199a and upregulating Rad23b expression, suggesting that irisin has clinical potential for the treatment of ALI.
genetics_overexpression_promote	33961511	hsa-mir-485	Osteoarthritis	CONCLUSION: Overexpression of miR
other	33961505	hsa-mir-222	Celiac Disease	3p increased specifically in CA HUVECs (72% and 53%, P = 0.04 and P = 0.06), whereas others did not change in either race.
other	33960958	hsa-mir-7977	Addison Disease	miR-7977 was upregulated in patients with coexisting autoimmune conditions vs those with isolated AD (P = 0.005, mean FC = 2.2). CONCLUSIONS: Our study demonstrates upregulated expression of miR-7977 in CD4+ T cells from patients with AD, especially with its polyendocrine form.
genetics_knock down_suppress	33960555	hsa-mir-4498	Osteoarthritis	We further determined that miR-4498 inhibitor reversed circSLC7A2-knockdown-induced OA phenotypes. CONCLUSIONS: The circSLC7A2/miR-4498/TIMP3 axis of chondrocytes catabolism and anabolism plays a critical role in OA development.
circulation_biomarker_diagnosis_ns	33960307	hsa-mir-660	ST Elevation Myocardial Infarction	CONCLUSION: Circulating miR
genetics_overexpression_promote	33960055	hsa-mir-21	Infertility	5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p < .05).
genetics_overexpression_promote	33960055	hsa-mir-155	Infertility	5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p < .05).
other	33959794	hsa-mir-26a	Rift Valley Fever	The results suggest the potential application of miR-26a in the treatment of RIF.
other	33959659	hsa-mir-93	Familial Primary Pulmonary Hypertension	5p expression was associated with the severity of CTEPH and could act as a potential predictor of high-risk CTEPH.
other	33959615	hsa-mir-222	Carcinoma, Non-Small-Cell Lung	Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC.
other	33959615	hsa-mir-221	Carcinoma, Non-Small-Cell Lung	Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC.
other	33959608	hsa-mir-487	Disease	MiR-487a expression was higher in ECs in the inner curvature (OS region) than the outer curvature of the rat aortic arch and thoracic aorta and also elevated in diseased human coronary arteries.
other	33959608	hsa-mir-487a	Disease	MiR-487a expression was higher in ECs in the inner curvature (OS region) than the outer curvature of the rat aortic arch and thoracic aorta and also elevated in diseased human coronary arteries.
exosome	33959603	hsa-mir-185	Vascular System Injuries	Exosomes derived from miR-185 mimic transfected VSMCs attenuated re-endothelialization after vascular injury. Taken together, our results indicate that exosomal miR-185 transfer from VSMCs to ECs is controlled by hnRNPA2B1 and impairs re-endothelialization after vascular injury.
target gene	33959508	hsa-mir-663a	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-6089	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-181a	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly down-regulated miRNAs
target gene	33959508	hsa-mir-4739	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-6769b	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-6892	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-7107	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-199a	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-1273g	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-6836	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-148a	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly down-regulated miRNAs
target gene	33959508	hsa-mir-1343	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959508	hsa-mir-24	Carcinoma, Hepatocellular	Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs
target gene	33959160	hsa-mir-182	Liver Neoplasms	mir-182-5p Regulates Cell Growth of Liver Cancer via Targeting RCAN1.
target gene	33958878	hsa-mir-7	Osteosarcoma	Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
genetics_overexpression_promote	33958865	hsa-mir-195	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Overexpression of miR
lncRNA target	33958720	hsa-mir-200a	Stomach Neoplasms	The expression of miR-200a was downregulated in human GC, correlating with upregulation of a novel miR-200a-targeting long non-coding RNA (LncRNA), PINK1 (PTEN Induced Kinase 1)-AS.
genetics_overexpression_suppress	33958701	hsa-mir-150	Colonic Neoplasms	3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133(+)CD44(+) cells using both in vitro and in vivo assays.
transcription factor target	33958654	hsa-mir-132	Epilepsy	Interestingly, the miRNA profile in the acute stage of infantile-onset TLE overlaps in dysregulation of miR
lncRNA target	33958547	hsa-mir-4787	Polycystic Kidney Diseases	In addition, polycystic kidney disease 1 gene, which encodes polycystin-1 (PC1), was found to be a direct target of miR
other	33958547	hsa-mir-4787	Alzheimer Disease	5p/polycystic kidney disease 1 axis in AD pathobiology.
genetics_knock down_promote	33958507	hsa-mir-217	Stomach Neoplasms	Moreover, circ_0000144 sponged miR-217, and rescue assays revealed that silencing miR-217 expression reversed the inhibitory effect of circ_0000144 knockdown on the progress of GC. Our findings reveal that circ_0000144 inhibition suppresses GC cell proliferation, migration and invasion via absorbing miR-217, providing a new biomarker and potential therapeutic target for treatment of GC.
other	33957967	hsa-mir-155	Behcet Syndrome	BACKGROUND: Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet's disease (BD) patients was decreased and affected cytokine production of DCs.
target gene	33957921	hsa-mir-595	Esophageal Squamous Cell Carcinoma	circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway.
lncRNA target	33957117	hsa-mir-205	Stomach Neoplasms	5p suppresses angiogenesis in GC by attenuating the expression of VEGFA and FGF1, indicating that upregulation of miR
genetics_overexpression_promote	33956530	hsa-mir-4709	Breast Neoplasms	3p mimic greatly inhibited the proliferation of breast cancer cells, whereas overexpression of miR
circulation_biomarker_diagnosis_ns	33956301	hsa-mir-145	Colorectal Neoplasms	5p and NRAS, confirmed with ROC curve analysis, these biomarkers may be useful in the screening and differentiating between tumor and control sample in colorectal neoplasm.
genetics_knock down_promote	33956079	hsa-mir-378c	Wilms Tumor	In addition, xenograft assay showed that miR-378c overexpression inhibited Wilms tumor development in vivo.
other	33956002	hsa-mir-200a	Ovarian Neoplasms	In the present study, a label-free electrochemical genosensor was designed based on ZnS quantum dots functionalized with l-cysteine (Cys-ZnS-QDs) to detect miR-200a, as a special ovarian cancer biomarker.
other	33955831	hsa-mir-601	Carcinoma, Hepatocellular	These results revealed lncRNA PP7080 effect in regulating miR-601/SIRT1 signal axis in the progression of HCC, indicating the important role of miR-601 in HCC pathogenesis.
transcription factor target	33955799	hsa-mir-133a	Carcinoma, Non-Small-Cell Lung	In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance.
transcription factor target	33955799	hsa-mir-206	Carcinoma, Non-Small-Cell Lung	In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance.
transcription factor target	33955799	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance.
transcription factor target	33955520	hsa-mir-101	Rift Valley Fever	On the whole, the present study demonstrates that miR101 is capable of inhibiting TGFbeta1induced tubular EMT by targeting TbetaRI, suggesting that it may be an important regulator of RIF.
other	33955520	hsa-mir-101	Fibrosis	Bioinformatics analyses revealed that miR101 was the miRNA that was most significantly downregulated in the fibrotic renal tissue samples, and this was confirmed by RTqPCR, which also demonstrated that this miRNA was downregulated in transforming growth factor (TGF)beta1treated human proximal tubular epithelial (HK2) cells.
other	33955520	hsa-mir-101	Kidney Diseases	Bioinformatics analyses revealed that miR101 was the miRNA that was most significantly downregulated in the fibrotic renal tissue samples, and this was confirmed by RTqPCR, which also demonstrated that this miRNA was downregulated in transforming growth factor (TGF)beta1treated human proximal tubular epithelial (HK2) cells.
lncRNA target	33955515	hsa-mir-93	Cerebral Hemorrhage	The present findings provided evidence to support miR935p as a potential therapeutic target for the treatment of ICH.
circulation_biomarker_diagnosis_ns	33955511	hsa-mir-135a	Non-alcoholic Fatty Liver Disease	In summary, circulating miR135a3p in EVs may serve as a potential noninvasive biomarker to diagnose NAFLD.
genetics_knock down_promote	33955508	hsa-mir-221	Influenza, Human	Furthermore, knockdown of SOCS1 efficiently abrogated the influences caused by miR221 inhibition on IAV replication and the typeI IFN response.
lncRNA target	33955505	hsa-mir-486	Mesothelioma	On the whole, the present study demonstrates that miR4865p may play an important role in MPM treatment by targeting multiple pathways involved in tumour development and progression.
lncRNA target	33955501	hsa-mir-129	Ovarian Neoplasms	These results indicated that HE4 promotes Pgpmediated drug resistance in ovarian cancer cells through the interactions with ANXA2, and the underlying mechanism may be associated with decreased expression of hsamiR1295p and dysregulation of the actin cytoskeleton signaling pathway.
lncRNA target	33955459	hsa-mir-543	Periodontitis	3p could down-regulate inflammation and inhibit periodontitis by targeting KLF6, and it provides a new insight into the molecular mechanism of periodontitis, which may be helpful for the early diagnosis and treatment of this disease.
lncRNA target	33955458	hsa-mir-21	Pulmonary Fibrosis	Our findings suggest that in addition to suppressing inflammation, the AM-RAMP2 system ameliorates pulmonary fibrosis by suppressing TGF-beta-Smad3 signaling, microRNA-21 activity and differentiation into non-p-MyoFbs.
lncRNA target	33955315	hsa-mir-340	Lung Neoplasms	5p/NET1 axis, suggesting a new approach to lung cancer clinical management.
other	33955243	hsa-mir-142	Bone Diseases	The regulatory roles of miR3p/HMGB1 in some orthopedic diseases have been determined successively, but there was no report about the degeneration of CEP.
other	33955243	hsa-mir-142	Neurodegenerative Diseases	The regulatory roles of miR3p/HMGB1 in some orthopedic diseases have been determined successively, but there was no report about the degeneration of CEP.
genetics_knock down_promote	33955122	hsa-mir-373	Choriocarcinoma	3p overexpression inhibited the migration by transwell methods of choriocarcinoma cells.
other	33954256	hsa-mir-495	Carcinoma, Renal Cell	In conclusion, down-regulation of circTLK1 restrained proliferation and metastasis and promoted apoptosis in RCC cells by modulating miR3p/CBL axis.
lncRNA target	33954190	hsa-mir-381	Cervical Intraepithelial Neoplasia	3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses.
lncRNA target	33954190	hsa-mir-130a	Cervical Intraepithelial Neoplasia	3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses.
lncRNA target	33954190	hsa-mir-4531	Cervical Intraepithelial Neoplasia	3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses.
lncRNA target	33954190	hsa-mir-205	Cervical Intraepithelial Neoplasia	3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses.
lncRNA target	33954185	hsa-mir-497	Acute Lung Injury	5p reduced ALI caused by sepsis through targeting IL2RB, indicating the potential effect of miR
lncRNA target	33954185	hsa-mir-497	Sepsis	5p reduced ALI caused by sepsis through targeting IL2RB, indicating the potential effect of miR
transcription factor target	33953853	hsa-mir-486a	Diabetic Cardiomyopathies	Bioinformatic analysis and apoptosis assessments revealed exercise exerted protective effects against DCM through miR-486a-5p release. CONCLUSION: Physical exercise inhibits cardiac remodelling in DCM, and the mechanism is associated with miR-486a-5p release-induced Mst1 inhibition.
exosome	33953745	hsa-mir-130a	Squamous Cell Carcinoma of Head and Neck	Our results suggest that exosomal miR-130a may serve as a promising diagnostic and prognostic biomarker for OSCC patients.
target gene	33953744	hsa-mir-139	Leukemia, Promyelocytic, Acute	miR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT.
other	33953665	hsa-mir-4456	Pulmonary Disease, Chronic Obstructive	miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease.
other	33953608	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	5p may play an oncogenic role in NSCLC.
lncRNA target	33953608	hsa-mir-183	Carcinoma, Non-Small-Cell Lung	3p could be used as a potential prognostic biomarker and therapeutic target to manage lung cancer.
therapeutic target	33953601	hsa-mir-195	Carcinoma, Non-Small-Cell Lung	Reversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene.
genetics_overexpression_promote	33953572	hsa-mir-140	Stomach Neoplasms	Moreover, we noticed that overexpression or downregulation of miR
lncRNA target	33953571	hsa-mir-211	Rectal Neoplasms	CONCLUSION: Down-regulation of EGOT could inhibit the growth of rectal cancer cells by regulating the miR
other	33953570	hsa-mir-140	Uterine Cervical Neoplasms	TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer.
other	33953222	hsa-mir-126	Colonic Neoplasms	High expression of miR-126 is an independent positive prognostic factor in stage I-III colon cancer.
lncRNA target	33953168	hsa-mir-23a	Sjogren's Syndrome	We demonstrate that miRNA-30a and miRNA-23a, increased in SM-EVs and neoplastic mast cell-derived EVs, attenuate osteoblast maturation by suppressing expression of RUNX2 and SMAD1/5, essential drivers of osteogenesis.
genetics_overexpression_promote	33952723	hsa-mir-142	Choroidal Neovascularization	3p was overexpressed in murine CNV lesions and its pharmacological inhibition decreased vascular and microglia densities by 46% and 30%, respectively.
lncRNA target	33952719	hsa-mir-222	Carcinoma, Hepatocellular	In summary, SOX2-mediated HCC progression through an axis involving CCAT1, EGFR, and miR
genetics_overexpression_promote	33952469	hsa-mir-663	Stomach Neoplasms	Overexpression of miR
circulation_biomarker_diagnosis_ns	33952466	hsa-mir-93	Hemoglobinuria, Paroxysmal	TCGA database analysis showed that miRNA-93 was increased in PC tissue. CONCLUSION: miRNA-93 contained in serum EVs may be a novel diagnostic and monitoring biomarker for PC.
genetics_GWAS	33952417	hsa-mir-210	Breast Neoplasms	RESULTS: In the GU-CCQ-BB population, miRSNPs TET2-rs7670522, ESR1-rs2046210, FGFR2-rs1219648, MIR210-rs1062099, HIF1A-rs2057482, and CASC16-rs4784227 were found to be associated with increased BC risk (P </= .05).
genetics_knock down_promote	33952250	hsa-mir-451	Breast Neoplasms	Interestingly, the inhibiting effects of LncRNA SNHG15 ablation on BC progression were abrogated by both silencing miR-451 and overexpressing c-Myc.
lncRNA target	33952191	hsa-mir-181c	Sepsis	CONCLUSION: Our research reveals that circPTK2 regulates microglia activation and hippocampal neuronal apoptosis induced by sepsis via miR-181c-5p-HMGB1 signaling.
genetics_overexpression_promote	33951295	hsa-mir-125b	Spinal Cord Injuries	miR-125b overexpression promotes neurological function recovery after SCI.
lncRNA target	33951290	hsa-mir-29b	Myocardial Reperfusion Injury	As a potential target gene of miR-29b, AKT3 plays a crucial role in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury, and this study aimed to investigate the potential role of high glucose in the outcome of I/R injury. In this study, we demonstrated that high glucose protects cardiomyocytes against I/R associated injury by suppressing apoptosis and high glucose promoted the expression of AKT3 by regulating the expression of circHIPK3/miR-29b.
genetics_GWAS	33950983	hsa-mir-363	Leukemia, Myeloid, Acute	3p may promote the development of RUNX1 mutation AML by targeting SPRYD4 and FNDC3B.
transcription factor target	33949939	hsa-mir-335	Brain Neoplasms	The other one is miR5p, which is a potential tumor suppressor miR in GBM, that was 5.66 folds upregulated in Aydin propolis treated GBM cells.
transcription factor target	33949939	hsa-mir-335	Glioblastoma	The other one is miR5p, which is a potential tumor suppressor miR in GBM, that was 5.66 folds upregulated in Aydin propolis treated GBM cells.
genetics_knock down_promote	33949774	hsa-mir-495	Pancreatic Carcinoma	A series of functional experiments indicated that upregulation of miR-495 or S100P knockdown suppressed pancreatic adenocarcinoma cells proliferation, invasion, and promoted apoptosis.
circulation_biomarker_diagnosis_ns	33949734	hsa-mir-181a	Esophageal Squamous Cell Carcinoma	3p (miR181a) serum levels in patients are predictive of the response to preoperative radiotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) and facilitate personalized treatment.
circulation_biomarker_diagnosis_ns	33949734	hsa-mir-181a-2	Esophageal Squamous Cell Carcinoma	The miR181a3p (miR181a) serum levels in patients are predictive of the response to preoperative radiotherapy in locally advanced esophageal squamous cell carcinoma (ESCC) and facilitate personalized treatment.
lncRNA target	33949293	hsa-mir-125b-2	Carcinoma, Hepatocellular	3p plays a tumor suppressive role in HCC.
lncRNA target	33949284	hsa-mir-2114	Osteosarcoma	Overall, our findings suggest that the previously uncharacterized regulatory axis of MIR205HG/miR3p/TWIST2 plays a critical role in promoting OS metastasis, which implies a potential therapeutic target in OS patients with metastasis.
lncRNA target	33949117	hsa-mir-454	Heart Failure	Furthermore, miR-454 activated the cAMP pathway via the NEDD4-2/TrkA axis, which ultimately suppressed cardiomyocyte apoptosis and attenuated myocardial damage.
other	33948855	hsa-mir-125a	Prostatic Neoplasms	5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer.
other	33948855	hsa-mir-100	Prostatic Neoplasms	Comparative analysis of the expression levels with tumor grading reveal that miR-100 was significantly down-regulated (p < 0.05) in high grade tumor, indicating that miR-100 associated with prostate cancer.
other	33948855	hsa-mir-20a	Prostatic Neoplasms	5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer.
other	33948855	hsa-mir-21	Prostatic Neoplasms	5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer.
other	33948855	hsa-mir-146a	Prostatic Neoplasms	5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer.
other	33948852	hsa-mir-156a	Stomatitis, Aphthous	Therefore, miR156a was the most stable miRNAs examined in this study, and could be used as a reference gene in poplar under canker pathogen stress, which should enable comprehensive comparisons of miRNAs expression and avoid the bias caused by different length between detected miRNAs and traditional reference genes.
other	33948374	hsa-mir-28	Colorectal Neoplasms	Our study provided a molecular basis for the development of 5-FU based chemotherapy resistance in CRC by LINC01347/miR-328/LOXL2 axis.
other	33948372	hsa-mir-16	Colorectal Neoplasms	Finally, increased frequencies of regulatory CD4(+)NKG2D(+) T cells with low miR-16 levels were observed in patients with late-stage colorectal cancer (Duke's C, D).
lncRNA target	33948369	hsa-mir-612	Endometrial Neoplasms	The bioinformatics analysis showed that PVT1/miR-612/CENP-H/CDK1 axis played a vital role in the malignant progression of advanced EC. In conclusion, the PVT1/miR-612/CENP-H/CDK1 axis promoted the malignant progression of advanced EC and could serve as a promising target for potential treatments.
target gene	33948156	hsa-mir-125a	Psoriasis	EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGFβ/SMAD pathway.
circulation_biomarker_diagnosis_ns	33946992	hsa-mir-21	Lung Neoplasms	5p and 210-3p), one sputum DNA methylation (RASSF1A), and two plasma miRNAs (miR
lncRNA target	33946612	hsa-mir-155	Pulmonary Fibrosis	SOCS1 is a target of microRNA-155 and although microRNA-155 levels were increased in IPF tissue, they were reduced in IPF fibroblasts.
transcription factor target	33946439	hsa-mir-21	Esophageal Squamous Cell Carcinoma	5p mimics or inhibitors had partial effects on cell proliferation and invasion in vitro.
transcription factor target	33946439	hsa-mir-210	Esophageal Squamous Cell Carcinoma	5p mimics or inhibitors had partial effects on cell proliferation and invasion in vitro.
other	33945794	hsa-mir-206	Fatty Liver	We demonstrate that miR-206 mimicry in vivo limits intramuscular fatty infiltration.
lncRNA target	33945659	hsa-mir-25	Spherocytosis, Type 1	5p might regulate the differentiation of EPCs partially through targeting ABCA1, and such a mechanism might account for HSS-induced differentiation of EPCs.
circulation_biomarker_diagnosis_up	33945535	hsa-mir-143	Adenomatous Polyposis Coli	Upregulation of plasma miR
lncRNA target	33945508	hsa-mir-206	Asthma	Overall, epithelial miR-206 upregulates airway IL-25 and TSLP expression by targeting the CD39-extracellular ATP axis, which represents a potentially novel therapeutic target in type 2-high asthma.
circulation_biomarker_diagnosis_ns	33945431	hsa-mir-145	Spinal Cord Injuries	5p plasmid were injected into the SCI rat model, and then rat damage was evaluated by BBB score, HE staining and Nissl staining.
genetics_knock down_promote	33945401	hsa-mir-515	Carcinoma, Non-Small-Cell Lung	In addition, circ_0017956 knockdown repressed NSCLC tumorigenesis by targeting miR
lncRNA target	33945396	hsa-mir-224	Osteoarthritis	In conclusion, our findings underscore a novel role of circ_PDE1C in OA pathogenesis and suggest that targeting circ_PDE1C/miR
lncRNA target	33945391	hsa-mir-206	Hemangioma, Cavernous	Thus, miR-206 could promote ECM accumulation through targeted inhibition of DNMT3A, further inhibiting the malignant development of HemECs and relieving IH.
lncRNA target	33945189	hsa-mir-29a	Renal Insufficiency, Chronic	CONCLUSION: PTH activates valvular EndMT via miR-29a-5p/GSAP/Notch1 pathway, which can contribute to VC in CKD rats.
other	33945148	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	CONCLUSION: Dexmedetomidine reduced 16HBE cells and AEC2 cell apoptosis and attenuated COPD by down-regulating miR-146a.
genetics_knock down_promote	33944676	hsa-mir-188	Multiple Myeloma	5p knockdown showed opposite effects on the MM cells in vitro and in vivo.
other	33943017	hsa-mir-1246	Acute Lung Injury	This study was carried out to analyze the interactions between Mirt2 and microRNA-1246 (miR-1246) in sepsis, with a specific focus on sepsis-induced acute lung injury (sepsis-ALI).
other	33943017	hsa-mir-1246	Sepsis	This study was carried out to analyze the interactions between Mirt2 and microRNA-1246 (miR-1246) in sepsis, with a specific focus on sepsis-induced acute lung injury (sepsis-ALI).
genetics_knock down_promote	33943007	hsa-mir-145	Nasopharyngeal Carcinoma	MiR-145 overexpression suppressed cell proliferation, migration, and angiogenesis in NPC, which was abolished by STMN1 overexpression.
other	33942991	hsa-mir-508	Pulmonary Arterial Hypertension	Experiment methods verified the functional expression of miR3p in PAH and its signalling cascade.
circRNA target	33942982	hsa-mir-136	Mucocutaneous Lymph Node Syndrome	miR-136 overturned the effects of circ_0023404 on HK-2 cell injury. In conclusion, we revealed circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R.
transcription factor target	33942935	hsa-mir-18a	gastric adenocarcinoma	The common signaling pathways further revealed that target genes of miR-18a-5p are involved in mixed-type GA progression. This study suggests that miR-18a-5p acts as a potential target for treatment, and common signal pathways provide a rich basis to seek reliable and effective molecular targets for the diagnosis, clinical treatment, and postoperative adjuvant therapy strategy of mixed-type GA.
other	33942704	hsa-mir-138	Osteoarthritis	5p and SIRT1 in chondrocytes, and to participate in the pathogenesis of OA.
circulation_biomarker_diagnosis_ns	33942497	hsa-mir-664	Osteoporosis	3p expression was markedly higher in the serum from patients with osteoporosis compared to that from normal subjects.
genetics_knock down_promote	33942497	hsa-mir-664	Bone Diseases	3p antagomir protected against ovariectomy-induced bone loss.
genetics_knock down_suppress	33942497	hsa-mir-664	Oophoritis	3p antagomir protected against ovariectomy-induced bone loss.
genetics_overexpression_promote	33942341	hsa-mir-34a	Tuberous Sclerosis	CONCLUSIONS: MicroRNA-34a is most highly overexpressed in tubers during foetal and early postnatal brain development.
lncRNA target	33942299	hsa-mir-124	Inflammatory Bowel Diseases	Our previous study has established the inhibitor of apoptosis-stimulating p53 protein (iASPP) as an oncogenic regulator in colorectal cancer by forming a regulatory axis or feedback loop with miR-124, p53, or p63.
other	33942238	hsa-mir-21	Pulmonary Fibrosis	miR-21 is increased in patients with IPF, but its function in the embryonic lung-derived diploid fibroblasts cells subjected to LPS is elusive.
transcription factor target	33942238	hsa-mir-21	Lung Injury	Totally, miR-21 aggravated the LPS-induced lung injury and modulated inflammatory responses by targeting TIMP3.
other	33942238	hsa-mir-21	Lung Diseases, Interstitial	miR-21 presented higher levels in interstitial pneumonia patients and LPS-induced WI-38 cells.
transcription factor target	33942217	hsa-mir-17	Diabetes Mellitus	Our findings suggest that hucMSC-EVs have regenerative and protective effects on HG-induced endothelial cells via transfer of miR5p targeting PTEN/ AKT/HIF-1alpha/VEGF pathway, thereby accelerating diabetic wound healing.
transcription factor target	33942214	hsa-mir-122	Cerebral Hemorrhage	Our findings reveal that IRN protects neurocyte from ICH-induced ferroptosis via miR5p/TP53/SLC7A11 pathway, which may provide a potential therapeutic mechanism for ICH.
genetics_GWAS	33941959	hsa-mir-146a	Breast Neoplasms	OBJECTIVE: To assess the association of miR-146a and its target protein RhoA expression levels in breast cancer. CONCLUSIONS: The miR-146a gene polymorphism rs2910164 G/C was found to have increased susceptibility to breast cancer at genotype and allelic levels.
genetics_overexpression_promote	33941868	hsa-mir-34b	Asthma	Notably, EZH2 and BTG2 were significantly overexpressed, while FOXO3 and miR-34b were obviously underexpressed in asthma.
lncRNA target	33941855	hsa-mir-100	Carcinoma	In support of a model whereby TGFbeta induces MIR100HG, which then enhances TGFbeta1 secretion, analysis of human carcinomas showed that MIR100HG expression correlated with expression of TGFB1 and its downstream extracellular target TGFBI. Thus, MIR100HG controls the magnitude of TGFbeta signaling via TGFbeta1 autoinduction and secretion in carcinomas.
other	33941855	hsa-mir-100	Pancreatic Carcinoma	mir-125b-1 cluster host gene (MIR100HG) expression in diverse cancer types, thus confirming an earlier demonstration of TGFbeta-mediated transcriptional induction of MIR100HG in pancreatic adenocarcinoma.
other	33941855	hsa-let-7a-2	Pancreatic Carcinoma	mir-125b-1 cluster host gene (MIR100HG) expression in diverse cancer types, thus confirming an earlier demonstration of TGFbeta-mediated transcriptional induction of MIR100HG in pancreatic adenocarcinoma.
other	33941699	hsa-let-7	Vector Borne Diseases	Here, we show that as the pathogenic fungus Beauveria bassiana penetrates into the host hemocoel, mosquitoes increase expression of the let-7 and miR-100 microRNAs (miRNAs). bassiana strains expressing anti-let-7 and anti-miR-100 are markedly more virulent to mosquitoes.
other	33941699	hsa-mir-100	Vector Borne Diseases	Here, we show that as the pathogenic fungus Beauveria bassiana penetrates into the host hemocoel, mosquitoes increase expression of the let-7 and miR-100 microRNAs (miRNAs). bassiana strains expressing anti-let-7 and anti-miR-100 are markedly more virulent to mosquitoes.
lncRNA target	33941559	hsa-mir-548c	Alzheimer Disease	Additionally, miR-548c- 3p is probably a common target for ADAMTS1, CITED2, and GABRA2.
epigenetics	33941064	hsa-mir-219-1	Glioblastoma	These findings suggested that DNA methylation has a crucial role in the regulation of miR
epigenetics	33941064	hsa-mir-219	Glioblastoma	These findings suggested that DNA methylation has a crucial role in the regulation of miR
circulation_biomarker_diagnosis_ns	33941051	hsa-mir-374a	Diabetic Retinopathy	Serum miR-374a was positively correlated with diabetes duration, fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), and homoeostasis model assessment of insulin resistance (HOMA-IR) in DR patients.
lncRNA target	33941019	hsa-mir-939	Wounds and Injuries	5p might present a new therapeutic target for PM(2.5) induced endothelial injury.
other	33940656	hsa-mir-204	Cardiovascular Diseases	We previously showed an association between miR5p and PR in stable cardiovascular patients, but data on functional mechanisms are lacking.
other	33940656	hsa-mir-204	Papillon-Lefevre Disease	5p were more reactive than controls.
other	33940617	hsa-mir-936	Schizophrenia	miR-936 upregulation in the DLPFC, therefore, can reduce glutamatergic synapses and weaken excitatory synaptic transmission, which underlie the synaptic pathology and hypofrontality in schizophrenia.
transcription factor target	33940568	hsa-mir-506	Burns	3p and its downstream target TGF-beta1 form a regulatory axis, modulating the cell viability, migration, and ECM synthesis in human dermal fibroblasts following burn injury.
lncRNA target	33939677	hsa-mir-15a	Pancreatic Carcinoma	Moreover, rescue assays verified that CERS6-AS1 was involved in cell proliferation and migration in PC via targeting miR-15a-5p/miR
lncRNA target	33939677	hsa-mir-6838	Pancreatic Carcinoma	Moreover, rescue assays verified that CERS6-AS1 was involved in cell proliferation and migration in PC via targeting miR-15a-5p/miR
transcription factor target	33939400	hsa-mir-211	Hypersensitivity	In conclusion, miR5p/-211 regulate alpha(S1)-casein and beta-casein synthesis via targeting CSN1S1 in GMEC, which provide the strategy for manipulating miR-204 family members to reduce milk allergy potential and improve ruminant milk quality for human consumption.
transcription factor target	33939400	hsa-mir-204	Hypersensitivity	In conclusion, miR5p/-211 regulate alpha(S1)-casein and beta-casein synthesis via targeting CSN1S1 in GMEC, which provide the strategy for manipulating miR-204 family members to reduce milk allergy potential and improve ruminant milk quality for human consumption.
transcription factor target	33939400	hsa-mir-211	Milk Hypersensitivity	In conclusion, miR5p/-211 regulate alpha(S1)-casein and beta-casein synthesis via targeting CSN1S1 in GMEC, which provide the strategy for manipulating miR-204 family members to reduce milk allergy potential and improve ruminant milk quality for human consumption.
transcription factor target	33939400	hsa-mir-204	Milk Hypersensitivity	In conclusion, miR5p/-211 regulate alpha(S1)-casein and beta-casein synthesis via targeting CSN1S1 in GMEC, which provide the strategy for manipulating miR-204 family members to reduce milk allergy potential and improve ruminant milk quality for human consumption.
exosome	33939301	hsa-mir-210	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Exosomal miR3p may play a crucial role in resistance to osimertinib in the tumor microenvironment of EGFR-mutant NSCLC.
lncRNA target	33939272	hsa-mir-29	Femur Head Necrosis	Also, biomechanical forces aggravated the pathogenesis of GIONFH through MALAT1/miR
transcription factor target	33939247	hsa-mir-486	Diabetic Nephropathies	Our collective findings indicate that lnc-ISG20 promotes the renal fibrosis process in DN by activating AKT through the miR5p/NFAT5 axis.
transcription factor target	33939247	hsa-mir-486	Fibrosis, Renal	Our collective findings indicate that lnc-ISG20 promotes the renal fibrosis process in DN by activating AKT through the miR5p/NFAT5 axis.
other	33938607	hsa-mir-375	Stomach Neoplasms	RESULTS: A cell model of Helicobacter pylori and gastric cancer was used to identify the expression of miR-375 and the maturity of dendritic cells.
genetics_overexpression_promote	33938174	hsa-mir-186	Colorectal Neoplasms	5p overexpression suppressed proliferation, cell viability, and migration while, it increased apoptosis in CRC cells, assessed by cell cycle, MTT, scratch and Annexin V/PI apoptosis assays.
genetics_GWAS	33937970	hsa-mir-146a	psoriasis 1	OBJECTIVE: We sought to study the importance of miR-146a in patients with moderate-to-severe psoriasis and to understand the impact of rs57095329 and rs2910164 polymorphisms in a psoriatic Portuguese population.
other	33937961	hsa-mir-15b	Uterine Cervical Neoplasms	These different changes in the expression levels of miR-34a and miR-15b along cervical carcinogenesis conduced to low apoptosis levels, high cell proliferation and finally, to cancerous cervical tissue development. Given the modifications in the expression levels of miR-34a and miR-15b during the development of cervical cancer, it will be useful to carry out further investigation to confirm them as molecular biomarkers of cancer.
other	33937961	hsa-mir-34a	Uterine Cervical Neoplasms	The aim of this study was to evaluate the miR-34a and miR-15b expression levels in the murine HPV16K14E7 (K14E7) transgenic model after chronic estrogen (E(2)) treatment and their involvement in CC.
lncRNA target	33937412	hsa-mir-210	Osteoarthritis	Thus, miR3p combined with BMMSCs is a candidate for future clinical applications in cartilage regeneration and could represent a promising new therapeutic target for OA.
circulation_biomarker_prognosis_up	33937336	hsa-mir-653	Stomach Neoplasms	5p was found to be significantly upregulated in GC tissues, serum, and cell lines and was strongly associated with poor prognosis in patients with GC.
lncRNA target	33937245	hsa-mir-376a	Rectal Neoplasms	Furthermore, for the clinical patient samples, the high expression of miR-376a was associated with the deregulation of CTC1 and a poor outcome for the rectum adenocarcinoma patients. Together, our results uncovered a novel role of miR-376a in stimulating rectum adenocarcinoma progression via CTC1 downregulating induced telomere dysfunction.
target gene	33937069	hsa-mir-646	Colorectal Neoplasms	The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
target gene	33937069	hsa-mir-381	Colorectal Neoplasms	The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
other	33937067	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	Here, we identify a super-enhancer associated with the MIR21 gene (MIR21-SE) by analyzing the MIR21 genomic regulatory landscape in head and neck squamous cell carcinoma (HNSCC).
lncRNA target	33937030	hsa-mir-93	Colorectal Neoplasms	Conclusion: CTBP1-AS2 promotes the TGF-beta/SMAD2/3 pathway activation by inhibiting miR
target gene	33937024	hsa-mir-338	Pancreatic Neoplasms	MiR-338-5p Inhibits EGF-Induced EMT in Pancreatic Cancer Cells by Targeting EGFR/ERK Signaling.
genetics_overexpression_suppress	33937023	hsa-mir-139	Carcinoma, Hepatocellular	Moreover, the overexpression of WTAP could partly abolish the inhibitory effects of miR
transcription factor target	33937021	hsa-mir-582	Carcinoma, Renal Cell	5p, which was regulated by RUNX1, inhibited tumor growth and invasion by targeting COL5A1, indicating that miR
circRNA target	33937016	hsa-mir-532	Carcinoma, Hepatocellular	CONCLUSIONS: Circ0013958 promotes HCC progression through miR
circulation_biomarker_diagnosis_ns	33936369	hsa-mir-382	Carcinoma, Non-Small-Cell Lung	Taken together, circulating exosomal miR-382 is a robust biomarker for evaluating the progression of NSCLC.
target gene	33936365	hsa-mir-105	Colonic Neoplasms	Long non-coding RNA CYTOR regulates proliferation and metastasis of colon cancer cells through regulating miRNA-105/PTEN axis.
circulation_biomarker_diagnosis_down	33936286	hsa-mir-1184	Sepsis	The results showed that miR-1184 was downregulated in the blood of children with sepsis and LPS-induced THP-1 cells.
target gene	33936279	hsa-mir-491	Carcinoma, Non-Small-Cell Lung	miR-491-5p inhibits the proliferation and migration of A549 cells by FOXP4.
lncRNA target	33936277	hsa-mir-155	Eosinophilic enteropathy	The present study suggests that the TGF-beta1/miR-155/MAPK axis is a novel target in the mechanism of EGD.
other	33936277	hsa-mir-155	Kidney Diseases	However, the potential role of miR-155 in early glomerular disease (EGD) remains elusive.
lncRNA target	33936273	hsa-mir-122	Ischemic Stroke	Therefore, the present study aimed to investigate the regulatory effect of microRNA (miR)-122 and its target gene repressor of RNA polymerase III transcription MAF1 homolog (Maf1) on the infarct area in ischemic stroke.
other	33936173	hsa-mir-34c	Carcinoma, Endometrioid	In addition, miR-34c cluster may be a key biomarker referring LNM in endometrial cancer.
exosome	33936086	hsa-mir-148a	Severe Acute Respiratory Syndrome	SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590.
exosome	33936086	hsa-mir-590	Severe Acute Respiratory Syndrome	SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590.
exosome	33936086	hsa-mir-590	COVID-19	SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590.
exosome	33936086	hsa-mir-148a	COVID-19	SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590.
transcription factor target	33936025	hsa-mir-21	Nasal Polyps	As a potential target of miR-21, the expression of PDCD4 was negatively correlated with miR-21 in CRSwNP.
genetics_knock down_promote	33935961	hsa-mir-214	ankylosing spondylitis 1	3p overexpression.
circulation_biomarker_diagnosis_up	33935780	hsa-mir-98	Glomerulonephritis, IGA	5p was significantly upregulated in the peripheral blood mononuclear cells (PBMCs) of pediatric patients with IgAN compared with patients diagnosed with mesangial proliferative glomerulonephritis (MsPGN) and immunoglobulin A vasculitis nephritis (IgAV-N), and healthy controls (p < 0.05).
other	33935775	hsa-mir-18a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Taken together, leonurine exerts significant anti-leukemia efficacy in CML by regulating miR-18a-5p/SOCS5/JAK2/STAT3 axis.
lncRNA target	33935726	hsa-mir-223	Gout	MicroRNA-223 Suppresses IL-1 and TNF- Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome.
lncRNA target	33935718	hsa-mir-486	Esophageal Squamous Cell Carcinoma	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-144	Esophageal Neoplasms	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-127	Esophageal Squamous Cell Carcinoma	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-34b	Esophageal Squamous Cell Carcinoma	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-127	Esophageal Neoplasms	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-486	Esophageal Neoplasms	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-34b	Esophageal Neoplasms	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
lncRNA target	33935718	hsa-mir-144	Esophageal Squamous Cell Carcinoma	Univariate cox regression analysis showed that there was no significant correlation between dysregulated miRNAs (such as hsa-miR-34b-3p, hsa-miR
genetics_knock down_promote	33935653	hsa-mir-146a	Alzheimer Disease	Knockdown of NF-kappaB or overexpression of TIGAR markedly attenuated oxidative stress and pyroptosis in AD-HHNs, while concurrent overexpression of miR-146a-5p inhibited these effects.
genetics_knock down_promote	33935653	hsa-mir-146a	Spinal Cord Injuries	Knockdown of NF-kappaB or overexpression of TIGAR markedly attenuated oxidative stress and pyroptosis in AD-HHNs, while concurrent overexpression of miR-146a-5p inhibited these effects.
other	33935503	hsa-mir-1182	Liver Neoplasms	A Novel Circular RNA circCSPP1 Promotes Liver Cancer Progression by Sponging miR-1182.
genetics_overexpression_promote	33935126	hsa-mir-138	Retinoblastoma	Overexpression of miR-138 in chemo-sensitive RB cell lines partly enhances cell viability after etoposide treatment.
transcription factor target	33934686	hsa-mir-212	Carcinoma, Hepatocellular	UBE2T, regulated by miR5p, significantly enhances the malignant phenotypes of HCC cells, which can be used as a target for HCC diagnosis and prognosis.
other	33934544	hsa-mir-10b	Heart Failure	Inside the cohort of advanced HF population, we identified three miRNAs (miR-125a-5p, miR-10b-5p, and miR5p) altered in HF patients experiencing the primary endpoint of cardiac death, heart transplantation, or mechanical circulatory support implantation when compared with those without clinical events.
other	33934544	hsa-mir-125a	Heart Failure	Inside the cohort of advanced HF population, we identified three miRNAs (miR-125a-5p, miR-10b-5p, and miR5p) altered in HF patients experiencing the primary endpoint of cardiac death, heart transplantation, or mechanical circulatory support implantation when compared with those without clinical events.
other	33934544	hsa-mir-9	Heart Failure	Inside the cohort of advanced HF population, we identified three miRNAs (miR-125a-5p, miR-10b-5p, and miR5p) altered in HF patients experiencing the primary endpoint of cardiac death, heart transplantation, or mechanical circulatory support implantation when compared with those without clinical events.
genetics_overexpression_promote	33934291	hsa-mir-624	Carcinoma, Hepatocellular	H3F3B overexpression reversed the repressive impact of miR-624 mimic on the Warburg effect and malignancy of HCC cells.
transcription factor target	33933678	hsa-mir-199a	Uterine Cervical Neoplasms	This study showed that HDAC6 suppresses the transcription of miR-199a and enhances the progression of HPV-positive cervical cancer through upregulation of Wnt5a.
lncRNA target	33933660	hsa-mir-338	Brain Ischemia	Brain-enriched microRNA-338 (miR-338) is known to play a central role in brain mitochondrial function, however the role of miR-338 in stroke injury remains unknown. These results suggest that miR-338 inhibition and/or COX4I1-targeted therapies may be novel clinical strategies to protect against stroke injury via preservation of mitochondrial function in multiple cell types.
other	33933426	hsa-mir-29b	Wounds and Injuries	Compared with the controls, wounds implanted with ADSC sheets had significantly higher rates of wound-closure; increased expression of alpha-SMA, VEGF, PI3k, PTEN, COL1A1, and COL3A1; decreased expression of PTEN and MMP1; and upregulated levels of miR-29b and miR-21 in the skin.
other	33933426	hsa-mir-21	Wounds and Injuries	Compared with the controls, wounds implanted with ADSC sheets had significantly higher rates of wound-closure; increased expression of alpha-SMA, VEGF, PI3k, PTEN, COL1A1, and COL3A1; decreased expression of PTEN and MMP1; and upregulated levels of miR-29b and miR-21 in the skin.
genetics_overexpression_promote	33933142	hsa-mir-199a	Ovarian Neoplasms	When overexpressed, lnc-CTSLP8 promoted ovarian cancer in vitro and in vivo by acting as a sponge for miR-199a-5p.
genetics_knock down_suppress	33932991	hsa-mir-182	Inflammation	5p inhibition-stimulated apoptosis, oxidative stress and inflammation were lessened by CXCL12 knockdown.
circRNA target	33932991	hsa-mir-182	Wounds and Injuries	CONCLUSION: Hsa_circ_0004831-targeted miR5p/CXCL12 regulatory network is one of the pathways by which ATV protects against ox-LDL-induced endothelial injuries.
lncRNA target	33932961	hsa-mir-22	Asthma	3p hampered airway inflammation and release of inflammatory cytokines through blocking the activation of the NLRP3-caspase
genetics_knock down_promote	33932899	hsa-mir-34a	Diabetic Nephropathies	Targeting modulation of p53/miR-34a/SIRT1 feedback by miR-34a knockdown or overexpression of SIRT1 could rescue podocyte injury during DN.
genetics_overexpression_promote	33932496	hsa-mir-135b	Colorectal Neoplasms	TXNIP was confirmed as a target of miR-135b-5p and overexpression of TXNIP could weaken the pro-CRC effect of exosomal miR-135b-5p, CONCLUSION: CAF-exos upregulate miR-135b-5p to promote CRC cell growth and angiogenesis by inhibiting TXNIP.
tissue_expression_ns	33932445	hsa-mir-140	Osteoarthritis	Enhanced miRNA-140 expression of osteoarthritis-affected human chondrocytes cultured in a polymer based three-dimensional (3D) matrix. AIMS We have evaluated the potential of a three-dimensional (3D) thermoreversible gelation polymer (TGP) matrix in enhancing miRNA 140 expression (a biomarker correlating with homeostasis and cartilage regeneration) during the in vitro expansion of osteoarthritis (OA)-affected human chondrocytes. SIGNIFICANCE The 3D-TGP matrix allows enhanced expression of miRNA 140 in OA-affected human chondrocytes in vitro which after necessary validations can be applied in clinical transplantation to significantly improve the outcome.
genetics_knock down_promote	33932399	hsa-mir-199b	Thyroid Neoplasms	OBJECTIVE: This research aims to investigate the relationship between the expression of microRNA-199b-5p (miR-199b-5p) and soluble human leukocyte antigen G (sHLA-G) in thyroid cancer tissues and its clinicopathological characteristics, as well as its impact on prognosis.
other	33932142	hsa-mir-503	Cicatrix, Hypertrophic	5p/ADAMTS14, AC000035.1-ADAMTS14 and hsa_circ_0069865-COMP/ADAM12 interaction pairs may play a central role in HS.
other	33932142	hsa-mir-204	Cicatrix, Hypertrophic	5p/ADAMTS14, AC000035.1-ADAMTS14 and hsa_circ_0069865-COMP/ADAM12 interaction pairs may play a central role in HS.
other	33932142	hsa-mir-431	Cicatrix, Hypertrophic	5p/ADAMTS14, AC000035.1-ADAMTS14 and hsa_circ_0069865-COMP/ADAM12 interaction pairs may play a central role in HS.
genetics_overexpression_suppress	33932136	hsa-mir-223	Inflammation	We previously demonstrated that microRNA(miR)-223 is overexpressed in intestinal tissue of infants with necrotizing enterocolitis (NEC).
genetics_overexpression_suppress	33932136	hsa-mir-223	Enterocolitis, Necrotizing	We previously demonstrated that microRNA(miR)-223 is overexpressed in intestinal tissue of infants with necrotizing enterocolitis (NEC).
circulation_biomarker_diagnosis_up	33931763	hsa-mir-26a	Diabetic  Retinopathy	A positive correlation between plasma miR-26a-5p level and the RNFL thickness of the superior quadrant of both eyes was identified in another cohort, including 33 mild NPDR cases, 33 matched non-DR patients and 20 healthy controls. CONCLUSIONS: Circulating miR-26a-5p is a potential biomarker for early-stage retinal neurodegeneration and it may be involved in the development of DR via profoundly influencing the functions of retinal cells.
circulation_biomarker_diagnosis_up	33931763	hsa-mir-26a	Diabetic Retinopathy	A positive correlation between plasma miR-26a-5p level and the RNFL thickness of the superior quadrant of both eyes was identified in another cohort, including 33 mild NPDR cases, 33 matched non-DR patients and 20 healthy controls. CONCLUSIONS: Circulating miR-26a-5p is a potential biomarker for early-stage retinal neurodegeneration and it may be involved in the development of DR via profoundly influencing the functions of retinal cells.
other	33931700	hsa-mir-451a	Encephalomyelitis, Autoimmune, Experimental	In this study, we examined the effect of HPV vaccines and EV miR-451a on murine experimental autoimmune encephalomyelitis (EAE), which is an autoimmune disorder that affects the central nervous system. Therefore, environmental factors that increase EV miR-451a levels exacerbate the autoimmune disorder more than the HPV vaccine.
other	33931593	hsa-let-7c	Adenocarcinoma of Lung	By integrated bioinformatics analyses of differentially expressed long noncoding RNAs (lncRNAs) and arm-level CNVs in lung adenocarcinoma (LUAD), we identified a potential antitumor gene, MIR99AHG, encoding lncRNA MIR99AHG as well as a miR-99a/let-7c/miR-125b2 cluster on chromosome 21q.
other	33931593	hsa-mir-125b-2	Adenocarcinoma of Lung	By integrated bioinformatics analyses of differentially expressed long noncoding RNAs (lncRNAs) and arm-level CNVs in lung adenocarcinoma (LUAD), we identified a potential antitumor gene, MIR99AHG, encoding lncRNA MIR99AHG as well as a miR-99a/let-7c/miR-125b2 cluster on chromosome 21q.
lncRNA target	33931593	hsa-mir-99a	Adenocarcinoma of Lung	In summary, MIR99AHG emerges as a noncoding tumor suppressor gene in LUAD, providing a new strategy for antitumor therapy.
lncRNA target	33931086	hsa-mir-27a	Carcinoma, Non-Small-Cell Lung	miR-27a-5p was confirmed as a tumor suppressor in NSCLC. CONCLUSIONS: KLF5-induced BBOX1-AS1 exerts tumor-promotive roles in NSCLC via sponging miR-27a-5p to activate MELK/FAK signaling, providing the possibility of employing BBOX1-AS1 as a therapeutic target for NSCLC patients.
exosome	33930499	hsa-mir-424	Polycystic Ovary Syndrome	These results demonstrate that exosomal miR
other	33930365	hsa-mir-148a	Osteonecrosis	Our aims are to investigate the mechanism of adipocyte-derived MVs-miR-148a in ONFH.
genetics_knock down_promote	33929992	hsa-mir-661	Breast Neoplasms	Collectively, hsa_circ_0069094 knockdown repressed breast cancer cell carcinogenesis and cell glycolysis by regulating HMGA1 through sponging miR-661, which provided a new insight for studying the mechanism of hsa_circ_0069094 in modulating breast cancer development.
genetics_overexpression_promote	33929991	hsa-mir-195	Colorectal Neoplasms	5p inhibitor and FZD4 overexpression could reverse the negative regulation of circRASSF2 silencing on CRC progression.
genetics_overexpression_promote	33929990	hsa-mir-5701	Carcinoma, Renal Cell	Furthermore, overexpression of PDE1B attenuated the effects of miR-5701, indicating that miR-5701 inhibited proliferation and promoted apoptosis of ccRCC cells via targeting PDE1B.
genetics_knock down_suppress	33929989	hsa-mir-188	Stomach Neoplasms	Knockdown of circ_0078607 inhibits the proliferation and induces apoptosis of gastric cancer via miR3p/RAP1B signal pathway.
lncRNA target	33929970	hsa-mir-29b	Pulmonary Fibrosis	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b
lncRNA target	33929970	hsa-mir-29b-2	Pulmonary Fibrosis	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b
other	33929592	hsa-mir-1202	Glaucoma	CONCLUSION: Hsa-miR-1260b was the most abundantly expressed among studied miRNAs and may be a potential biomarker of clinical status in PEXG and PACG.
other	33929592	hsa-mir-1260b	Glaucoma	CONCLUSION: Hsa-miR-1260b was the most abundantly expressed among studied miRNAs and may be a potential biomarker of clinical status in PEXG and PACG.
transcription factor target	33929592	hsa-mir-4634	Glaucoma	Target annotation and functional analyses showed that genes targeted by the most frequently expressed miRNAs (hsa-miR-1202, -1260b, -184,
lncRNA target	33929392	hsa-mir-455	Myocardial Infarction	3p/PTAFR axis, providing a potential molecular target for MI therapy.
genetics_overexpression_promote	33928819	hsa-mir-375	Ovarian Neoplasms	Overexpressed miR-375 in vivo inhibited OC progression.
lncRNA target	33928771	hsa-mir-185	Osteoporosis-pseudoglioma syndrome	Taken together, down-regulation of SNHG14 in hBMSCs accelerated the progression of OP via regulating miR5p/WISP2 axis.
lncRNA target	33928675	hsa-mir-125b	Non-alcoholic Fatty Liver Disease	Targeting the biliary SCT/SCTR/miR-125b axis may be key for ameliorating phenotypes of human NAFLD/NASH.
lncRNA target	33928608	hsa-mir-326	Squamous Cell Carcinoma of Head and Neck	The mutual inhibition between the expressions of lncRNA PRNCR1 and miR-326 was identified in OSCC.
genetics_knock down_suppress	33928606	hsa-mir-217	Urinary Bladder Neoplasms	OIP5-AS1 knockdown inhibits human BCa cell proliferation and invasion through miR-217/MTDH axis.
lncRNA target	33928605	hsa-mir-503	Uterine Cervical Neoplasms	In vitro studies have shown that MIR503HG inhibited cell proliferation and invasion, and enhanced cell apoptosis in cervical cancer through the miR-191/CEBPB axis.
target gene	33928594	hsa-mir-101	Uterine Cervical Neoplasms	MiR-101 affects proliferation and apoptosis of cervical cancer cells by inhibition of JAK2.
lncRNA target	33928467	hsa-mir-30	Carcinoma, Non-Small-Cell Lung	5p, thus, resulting in the inhibition of NSCLC cell growth.
other	33928027	hsa-mir-223	Triple Negative Breast Neoplasms	miR-223 is a valid and independent prognostic biomarker in BC.
lncRNA target	33928018	hsa-mir-1270	Urinary Bladder Neoplasms	CONCLUSIONS: CircZFR promotes the proliferation, migration and invasion of BCa cells by upregulating WNT5A signaling pathway via sponging miR-545 and miR-1270.
lncRNA target	33928018	hsa-mir-545	Urinary Bladder Neoplasms	CONCLUSIONS: CircZFR promotes the proliferation, migration and invasion of BCa cells by upregulating WNT5A signaling pathway via sponging miR-545 and miR-1270.
transcription factor target	33927285	hsa-mir-383	Depression	Downregulation of miR-383 ameliorated the behavioral and neurochemical changes induced by chronic stress in rats by directly targeting Wnt2, indicating that the miR-383/Wnt2 axis might be a potential therapeutic target for MDD.
other	33926561	hsa-mir-126	Osteoarthritis	3p which is involved in modulation of anabolic response of OA-CH.
genetics_knock down_promote	33926524	hsa-mir-503	Esophageal Squamous Cell Carcinoma	CONCLUSION: This work elucidates that HDAC2 knockdown retards the process of ESCC by elevating miR
epigenetics	33926515	hsa-mir-29c	Breast Neoplasms	We found deregulation of hsa-miR-29c-5p already present in pre-invasive breast lesions and postulate that hsa-miR-29c-5p may trigger early event abnormal DNA methylation in ER-positive breast cancer.
lncRNA target	33926489	hsa-mir-107	Ovarian Neoplasms	CONCLUSIONS: LncRNA AFAP1-AS1 serves as a tumor driver in the pathogenesis of OC via the miR-107/PDK4 axis.
transcription factor target	33926470	hsa-mir-190	Bulimia Nervosa	These two aspects led to miR-190 inhibition of p27 protein expression in human BC cells.
circRNA target	33926347	hsa-mir-1179	Thyroid Cancer, Papillary	It was also confirmed that HMGB1 was a direct target of miR-1179 and mediated the effects of circ_0062389 and miR-1179 in PTC.
lncRNA target	33925948	hsa-mir-217	Pancreatic Carcinoma	Transfecting miR-217 mimic in pancreatic cancer cells reduced viability, enhanced apoptosis, and affected cell cycle by promoting a S phase arrest in gemcitabine-treated cells.
genetics_GWAS	33925397	hsa-mir-155	Acquired Immunodeficiency Syndrome	Iodixanol velocity gradient provided the optimal separation of EVs from viruses and free proteins in culture supernatants and plasma samples from a person living with HIV (PLWH) or a control and revealed a new population of large EVs enriched in microRNA miR-155 and mitochondrial DNA. By revealing a new population of EVs enriched in miR-155 and mitochondrial DNA, this study paves a way to increase our understanding of HIV-1 pathogenesis.
other	33925234	hsa-mir-7484-1	Infertility, Male	Overall, a putative CMS mechanism involving mitochondrial dysfunction, the ghi-MIR7484-10/MAPKK6 network, and reduced glucose metabolism was suggested, and ghi-MIR7484-10/MAPKK6 may be related to abnormal microspore meiosis and induction of excessive sucrose accumulation in anthers.
other	33925232	hsa-mir-146a	Diabetes Mellitus, Type 2	Therefore, the current study was designed to investigate the association of rs11614913 T/C (MIR196A2), rs2910164 G/C (MIR146A), and rs6505162 C/A (MIR423) in clinicopathological proven T2DM patients and gender-matched healthy controls.
other	33925232	hsa-mir-196a-2	Diabetes Mellitus, Type 2	Therefore, the current study was designed to investigate the association of rs11614913 T/C (MIR196A2), rs2910164 G/C (MIR146A), and rs6505162 C/A (MIR423) in clinicopathological proven T2DM patients and gender-matched healthy controls.
other	33925232	hsa-mir-423	Diabetes Mellitus, Type 2	Therefore, the current study was designed to investigate the association of rs11614913 T/C (MIR196A2), rs2910164 G/C (MIR146A), and rs6505162 C/A (MIR423) in clinicopathological proven T2DM patients and gender-matched healthy controls.
other	33924725	hsa-mir-122	Fatty Liver	This combination of plant extracts had a beneficial effect on HFD-induced NAFLD by the modulation of miR-122, miR-34a and gut microbiome.
other	33924725	hsa-mir-34a	Fatty Liver	This combination of plant extracts had a beneficial effect on HFD-induced NAFLD by the modulation of miR-122, miR-34a and gut microbiome.
circulation_biomarker_diagnosis_ns	33924670	hsa-mir-20a	Breast Neoplasms	We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse.
circulation_biomarker_diagnosis_ns	33924670	hsa-mir-126	Breast Neoplasms	We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse.
circulation_biomarker_diagnosis_ns	33924670	hsa-mir-10b	Breast Neoplasms	We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse.
circulation_biomarker_diagnosis_ns	33924670	hsa-mir-155	Breast Neoplasms	We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse.
circulation_biomarker_diagnosis_ns	33924670	hsa-mir-19a	Breast Neoplasms	We investigated the differential expression of the immunomodulatory miR-10b, miR-19a, miR-20a, miR-126, and miR-155 in the plasma of healthy women and patients with early stage breast cancer and interrogated their role in the prediction of patients' relapse.
circulation_biomarker_diagnosis_ns	33924204	hsa-mir-24-2	Acquired Immunodeficiency Syndrome	5p is significantly altered in HIV+OP+ individuals, in line with data on other causes of osteoporosis, suggesting a common pattern of circulating miRNAs independent of the underlying cause.
circulation_biomarker_diagnosis_ns	33924204	hsa-mir-23a	Acquired Immunodeficiency Syndrome	5p is significantly altered in HIV+OP+ individuals, in line with data on other causes of osteoporosis, suggesting a common pattern of circulating miRNAs independent of the underlying cause.
circulation_biomarker_diagnosis_ns	33924204	hsa-mir-21	Acquired Immunodeficiency Syndrome	5p is significantly altered in HIV+OP+ individuals, in line with data on other causes of osteoporosis, suggesting a common pattern of circulating miRNAs independent of the underlying cause.
other	33924142	hsa-let-7b	Urinary Bladder Neoplasms	5p were significantly increased in the urine of patients with bladder cancer compared with those of controls.
other	33924142	hsa-mir-146a	Urinary Bladder Neoplasms	5p were significantly increased in the urine of patients with bladder cancer compared with those of controls.
other	33924142	hsa-mir-423	Urinary Bladder Neoplasms	5p were significantly increased in the urine of patients with bladder cancer compared with those of controls.
transcription factor target	33923995	hsa-mir-185	Pre-Eclampsia	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
transcription factor target	33923995	hsa-mir-185	Fetal Growth Retardation	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
transcription factor target	33923995	hsa-mir-15b	Fetal Growth Retardation	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
transcription factor target	33923995	hsa-mir-1	Fetal Growth Retardation	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
transcription factor target	33923995	hsa-mir-1	Pre-Eclampsia	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
transcription factor target	33923995	hsa-mir-15b	Pre-Eclampsia	In placental bed samples, significant changes in the ratio of miRNA and its potential target gene expression levels were revealed, which were unique for IUGR (miR-30c-5p/VIM, miR
other	33923732	hsa-mir-181a	Breast Neoplasms	Thus, the association of miR-19b, miR-22, miR-222, miR-378a, and miR-181a levels with BC characteristics is influenced by the status of tumor ER, PR, HER2, and Ki-67.
other	33923614	hsa-mir-145	Diabetes Mellitus, Type 2	We hypothesised that increased expression of microRNA-145 plays a functional role in DNA damage signalling and subsequent cellular senescence specifically in SMC cultured from the vasculature of T2DM patients.
circulation_biomarker_diagnosis_ns	33923577	hsa-mir-378	Anodontia	Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNF), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378.
other	33923455	hsa-mir-574	Asthma	Using logistic regression, microRNA hsa-miR5p had a good prognostic ability for incident asthma prognosis with an area under the receiver operating characteristic (AUROC) of 0.83.
other	33923310	hsa-mir-155	Acquired Immunodeficiency Syndrome	In HIV+ART, only miR-155 daily variation has been observed in large EVs.
circulation_biomarker_diagnosis_ns	33923172	hsa-mir-628	Pre-Eclampsia	Specific microRNAs including hsa-miRs 3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.
circulation_biomarker_diagnosis_ns	33922968	hsa-mir-375	Prostatic Neoplasms	3p in blood plasma show higher performance than PSA in discriminating PCa from BPH.
circulation_biomarker_diagnosis_ns	33922968	hsa-mir-182	Prostatic Neoplasms	3p in blood plasma show higher performance than PSA in discriminating PCa from BPH.
other	33922958	hsa-mir-141	Stroke	3p probes could be used as a potential treatment for ischemic stroke.
genetics_knock down_promote	33922649	hsa-mir-542	Glioma	3p and HK2 in glioma tissues from patients with low- and high-grade gliomas using imaging analysis; (3) Results: We show that knockdown of miR
other	33922375	hsa-mir-664b	Mastitis, Bovine	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-664b	Mastitis	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-23b	Mastitis	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-19b	Mastitis	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-23b	Mastitis, Bovine	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-31	Mastitis	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-19b	Mastitis, Bovine	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
other	33922375	hsa-mir-31	Mastitis, Bovine	3p were potential factors regulating the expression levels of CD14 Molecule (CD14), G protein subunit gamma 2 (GNG2), interleukin 17A (IL17A), collagen type IV alpha 1 chain (COL4A1), microtubule associated protein RP/EB family member 2 (MAPRE2), member of RAS oncogene family (RAP1B), LDOC1 regulator of NFKB signaling (LDOC1), low-density lipoprotein receptor (LDLR) and S100 calcium binding protein A9 (S100A9) in bovine mastitis caused by S.
exosome	33921710	hsa-mir-125b	Encephalitis, Japanese	The high level of miR-125b-5p in persistently JEV-infected cells was confirmed by Northern analysis and real-time quantitative polymerase chain reaction. This is the first report to characterize the potential roles of miR-125b-5p in persistent JEV infections.
other	33921319	hsa-mir-210	Colorectal Neoplasms	Clinically, the miRSTMN1 axis was activated in CRC patients with liver metastasis and correlated with a worse clinical outcome.
genetics_overexpression_promote	33921262	hsa-mir-210	Pneumonia, Mycoplasma	3p may play a role in regulating events associated with enEVT functions and its overexpression could impair spiral artery remodeling, thereby contributing to PE.
other	33921262	hsa-mir-210	Pre-Eclampsia	3p's role in the pathogenesis of PE is still under investigation.
circulation_biomarker_diagnosis_up	33919942	hsa-mir-137	Coronary Artery Disease	CONCLUSIONS Nourin-dependent miR-137 and miR-106b-5p are promising novel blood-based biomarkers for early diagnosis of myocardial ischemia in chest pain patients suspected of CAD in outpatient clinics.
circulation_biomarker_diagnosis_up	33919942	hsa-mir-106b	Myocardial Infarction	CONCLUSIONS Nourin-dependent miR-137 and miR-106b-5p are promising novel blood-based biomarkers for early diagnosis of myocardial ischemia in chest pain patients suspected of CAD in outpatient clinics.
circulation_biomarker_diagnosis_up	33919942	hsa-mir-106b	Coronary Artery Disease	CONCLUSIONS Nourin-dependent miR-137 and miR-106b-5p are promising novel blood-based biomarkers for early diagnosis of myocardial ischemia in chest pain patients suspected of CAD in outpatient clinics.
circulation_biomarker_diagnosis_up	33919942	hsa-mir-137	Myocardial Infarction	CONCLUSIONS Nourin-dependent miR-137 and miR-106b-5p are promising novel blood-based biomarkers for early diagnosis of myocardial ischemia in chest pain patients suspected of CAD in outpatient clinics.
transcription factor target	33919884	hsa-mir-18	Breast Neoplasms	Fifteen candidate female-biased BC genes targeted by 3 X-linked miRNAs (has-mir-18hashsa-mir-221, and hsa-mir-224) were pinpointed in this study.
transcription factor target	33919884	hsa-mir-221	Breast Neoplasms	Fifteen candidate female-biased BC genes targeted by 3 X-linked miRNAs (has-mir-18hashsa-mir-221, and hsa-mir-224) were pinpointed in this study.
other	33919834	hsa-mir-17	Premature Birth	3p).
other	33919834	hsa-mir-100	Premature Birth	3p).
other	33919834	hsa-mir-199a	Pregnancy Complications	3p).
other	33919834	hsa-mir-21	Pregnancy Complications	3p).
other	33919834	hsa-mir-143	Premature Birth	3p).
other	33919834	hsa-mir-130b	Pregnancy Complications	3p).
other	33919834	hsa-mir-143	Pregnancy Complications	3p).
other	33919834	hsa-mir-130b	Premature Birth	3p).
other	33919834	hsa-mir-126	Pregnancy Complications	3p).
other	33919834	hsa-mir-126	Premature Birth	3p).
other	33919834	hsa-mir-100	Pregnancy Complications	3p).
other	33919834	hsa-mir-20a	Premature Birth	3p).
other	33919834	hsa-mir-20a	Pregnancy Complications	3p).
other	33919834	hsa-mir-29a	Premature Birth	3p).
other	33919834	hsa-mir-574	Pregnancy Complications	3p).
other	33919834	hsa-mir-125b	Premature Birth	3p).
other	33919834	hsa-mir-125b	Pregnancy Complications	3p).
other	33919834	hsa-mir-1	Pregnancy Complications	3p).
other	33919834	hsa-mir-29a	Pregnancy Complications	3p).
other	33919834	hsa-mir-20b	Pregnancy Complications	3p).
other	33919834	hsa-mir-574	Premature Birth	3p).
other	33919834	hsa-mir-146a	Premature Birth	3p).
other	33919834	hsa-mir-21	Premature Birth	3p).
other	33919834	hsa-mir-17	Pregnancy Complications	3p).
other	33919834	hsa-mir-24	Premature Birth	3p).
other	33919834	hsa-mir-499a	Premature Birth	3p).
other	33919834	hsa-mir-499a	Pregnancy Complications	3p).
other	33919834	hsa-mir-1	Premature Birth	3p).
other	33919834	hsa-mir-26a	Pregnancy Complications	3p).
other	33919834	hsa-mir-20b	Premature Birth	3p).
other	33919834	hsa-mir-24	Pregnancy Complications	3p).
other	33919834	hsa-mir-26a	Premature Birth	3p).
other	33919834	hsa-mir-199a	Premature Birth	3p).
other	33919834	hsa-mir-221	Premature Birth	3p).
other	33919834	hsa-mir-221	Pregnancy Complications	3p).
other	33919834	hsa-mir-146a	Pregnancy Complications	3p).
circulation_biomarker_diagnosis_ns	33919053	hsa-mir-150	Cardiovascular Diseases	3p was quantified in plasma samples of stable CVD patients and correlated with PR as assessed by light-transmission aggregometry and in vivo thrombin generation markers.
circulation_biomarker_diagnosis_ns	33919053	hsa-mir-126	Cardiovascular Diseases	3p was quantified in plasma samples of stable CVD patients and correlated with PR as assessed by light-transmission aggregometry and in vivo thrombin generation markers.
circulation_biomarker_diagnosis_ns	33919053	hsa-mir-223	Cardiovascular Diseases	3p was quantified in plasma samples of stable CVD patients and correlated with PR as assessed by light-transmission aggregometry and in vivo thrombin generation markers.
circulation_biomarker_diagnosis_ns	33919053	hsa-mir-204	Cardiovascular Diseases	3p was quantified in plasma samples of stable CVD patients and correlated with PR as assessed by light-transmission aggregometry and in vivo thrombin generation markers.
circulation_biomarker_diagnosis_up	33918859	hsa-mir-19b	Triple Negative Breast Neoplasms	Herein, we identified significant differentially expressed circulating miRNAs in TNBC patients (miR-19a/b-3p, miR
circulation_biomarker_diagnosis_up	33918859	hsa-mir-19a	Triple Negative Breast Neoplasms	Herein, we identified significant differentially expressed circulating miRNAs in TNBC patients (miR-19a/b-3p, miR
circulation_biomarker_diagnosis_up	33918859	hsa-mir-210	Triple Negative Breast Neoplasms	Herein, we identified significant differentially expressed circulating miRNAs in TNBC patients (miR-19a/b-3p, miR
circulation_biomarker_diagnosis_up	33918859	hsa-mir-93	Triple Negative Breast Neoplasms	Herein, we identified significant differentially expressed circulating miRNAs in TNBC patients (miR-19a/b-3p, miR
other	33917851	hsa-mir-24	Carotid Stenosis	Admission glucose values (HR (hazard ratio) 1.020, CI (confidence of interval) 95% (1.001-1.038), p = 0.029), atheromatous carotid plaque (HR 5.373, CI 95% (1.251-11.079), p = 0.024), and miR-24 (HR 3.842, CI 95% (1.768-19.222), p = 0.011) predicted MACE at 2 years of follow-up. MiR24, hyperglycemia, and atheromatous plaque could predict MACE at 2 years of follow-up.
other	33917851	hsa-mir-133	Carotid Stenosis	At 2 years of follow-up, PDNMU versus NG, PDMU versus NG, and PDNMU versus PDMU over-expressed inflammatory markers and miR-24, miR-27, miR-100, miR-126, and miR-133 (p < 0.05).
other	33917851	hsa-mir-100	Carotid Stenosis	At 2 years of follow-up, PDNMU versus NG, PDMU versus NG, and PDNMU versus PDMU over-expressed inflammatory markers and miR-24, miR-27, miR-100, miR-126, and miR-133 (p < 0.05).
other	33917851	hsa-mir-126	Carotid Stenosis	At 2 years of follow-up, PDNMU versus NG, PDMU versus NG, and PDNMU versus PDMU over-expressed inflammatory markers and miR-24, miR-27, miR-100, miR-126, and miR-133 (p < 0.05).
other	33917851	hsa-mir-27	Carotid Stenosis	At 2 years of follow-up, PDNMU versus NG, PDMU versus NG, and PDNMU versus PDMU over-expressed inflammatory markers and miR-24, miR-27, miR-100, miR-126, and miR-133 (p < 0.05).
other	33917769	hsa-mir-224	Hypertension, Pulmonary	We found that pulmonary artery fibroblasts isolated from IPAH patients (PH-Fibs) exhibit reduced levels of mature miR-124 and several other miRNAs including let-7i, miR-224, and miR-210, and that these reduced levels can be restored by HDACi.
other	33917769	hsa-mir-210	Hypertension, Pulmonary	We found that pulmonary artery fibroblasts isolated from IPAH patients (PH-Fibs) exhibit reduced levels of mature miR-124 and several other miRNAs including let-7i, miR-224, and miR-210, and that these reduced levels can be restored by HDACi.
genetics_GWAS	33917769	hsa-mir-124-1	Hypertension, Pulmonary	Thus, our data indicate epigenetic events play important role in controlling miR-124 and likely other miRNA levels and epigenetic regulators such as HDACs appear to be promising therapeutic targets for chronic PH.
genetics_GWAS	33917769	hsa-mir-124	Hypertension, Pulmonary	Thus, our data indicate epigenetic events play important role in controlling miR-124 and likely other miRNA levels and epigenetic regulators such as HDACs appear to be promising therapeutic targets for chronic PH.
circulation_biomarker_prognosis_down	33917510	hsa-mir-877	Uterine Cervical Neoplasms	3p is a potential therapeutic target whose inhibition improves paclitaxel effects; (ii) the expression and location of its target ZNF177 could be diagnostic biomarkers between HSIL and SCCC; and (iii) cytoplasmic ZNF177 is a poor-prognosis biomarker in SCCC.
other	33917405	hsa-mir-144	Carcinoma, Renal Cell	3p's potential as biomarkers of clear cell RCC (ccRCC), establishing their role in its glycolysis status.
other	33917405	hsa-mir-186	Carcinoma, Renal Cell	3p's potential as biomarkers of clear cell RCC (ccRCC), establishing their role in its glycolysis status.
circulation_biomarker_diagnosis_ns	33916610	hsa-mir-126	Colorectal Neoplasms	Serum levels of miR
circulation_biomarker_diagnosis_ns	33916610	hsa-mir-152	Colorectal Neoplasms	Serum levels of miR
circulation_biomarker_diagnosis_ns	33916610	hsa-mir-92a-1	Colorectal Neoplasms	Serum levels of miR
circulation_biomarker_diagnosis_ns	33916610	hsa-mir-362	Colorectal Neoplasms	Serum levels of miR
circulation_biomarker_diagnosis_ns	33916195	hsa-mir-34a	mitochondrial DNA depletion syndrome 4b	5p and miR-34a-5p) and three serum miRNAs (miR
circulation_biomarker_diagnosis_ns	33916195	hsa-mir-194	mitochondrial DNA depletion syndrome 4b	5p and miR-34a-5p) and three serum miRNAs (miR
circulation_biomarker_diagnosis_ns	33916195	hsa-mir-192	mitochondrial DNA depletion syndrome 4b	5p and miR-34a-5p) and three serum miRNAs (miR
circulation_biomarker_diagnosis_ns	33916195	hsa-mir-193a	mitochondrial DNA depletion syndrome 4b	5p and miR-34a-5p) and three serum miRNAs (miR
transcription factor target	33915898	hsa-mir-100	Retinal Degeneration	These findings support that miR-100 at least in part mediates H(2)O(2)-induced cell death of ARPE-19 cells and can be regarded as a preventive and therapeutic target for retinal degenerative disease.
circulation_biomarker_diagnosis_up	33915734	hsa-mir-483	Alzheimer Disease	5p as the most upregulated miRNA amongst a panel of miRNAs in blood plasma specific to prodromal, early-stage Alzheimer's disease patients.
genetics_overexpression_promote	33915247	hsa-mir-873	Pancreatic Carcinoma	Overexpressed miR-873 or silenced PLEK2 inhibited the self-renewal and proliferation while promoting the apoptosis of pancreatic cancer stem cells.
lncRNA target	33914383	hsa-mir-150	Diabetic Nephropathies	Collectively, our findings indicate that NEAT1 facilitates high glucose-induced damage in HK-2 cells by suppressing mitophagy via the miR
other	33913671	hsa-mir-493	Melanoma	CONCLUSIONS: ILF3-AS1 promotes the aerobic glycolysis and survival of melanoma cells involving miR5p/PDK1 pathway.
lncRNA target	33913391	hsa-mir-326	Adenocarcinoma of Lung	MiR-326 could target ZEB1 to inhibit the proliferation, invasion and migration of lung adenocarcinoma cells and promote apoptosis, which is a potential therapeutic target for lung adenocarcinoma.
lncRNA target	33913264	hsa-mir-874	Retinal Diseases	CONCLUSIONS: miR-874 modulates the NF-kappaB signaling pathway by targeting the degradation of p65 to further improve the retina of diabetic rats, thus demonstrating the beneficial effect of miR-874 on diabetic retinopathy in rats.
lncRNA target	33913264	hsa-mir-874	Diabetes Mellitus	CONCLUSIONS: miR-874 modulates the NF-kappaB signaling pathway by targeting the degradation of p65 to further improve the retina of diabetic rats, thus demonstrating the beneficial effect of miR-874 on diabetic retinopathy in rats.
lncRNA target	33913242	hsa-mir-23b	Cholangiocarcinoma	miR-23b-3p was regarded as a target of LINC00184 and its depletion perversed the inhibitive influence of LINC00184 silencing on cholangiocarcinoma cells.
transcription factor target	33912994	hsa-mir-27a	Squamous Cell Carcinoma of Head and Neck	RESULTS: miR-27a was a key miRNA in TSCC, which was significantly up-regulated in both Cal-27 cells and malignant tissues from the TSCC patients. CONCLUSION: Our findings strongly suggest that miR-27a could promote the tumorigenesis and development of TSCC, which makes it a potential new diagnostic marker and therapeutic target for TSCC.
other	33912703	hsa-mir-20b	Stomach Neoplasms	MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT.
other	33912463	hsa-mir-124	Triple Negative Breast Neoplasms	The miR-124-3p/Neuropilin-1 Axis Contributes to the Proliferation and Metastasis of Triple-Negative Breast Cancer Cells and Co-Activates the TGF-β Pathway.
genetics_overexpression_promote	33912460	hsa-mir-640	Breast Neoplasms	Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect.
lncRNA target	33912133	hsa-mir-18a	Atherosclerosis	Downregulation of miR-18a-5p expression or upregulation of PGC-1alpha in ox-LDL treated HAECs could reverse mitochondrial energy metabolism disorder. In conclusion, these findings suggested that FENDRR/miR-18a-5p/PGC-1alpha signaling pathway regulated mitochondrial energy metabolism in HAECs; ox-LDL downregulated the expression of PGC-1alpha and cause mitochondrial energy metabolism disorder by inhibiting this signal pathway.
target gene	33911969	hsa-mir-567	Carcinoma, Non-Small-Cell Lung	MicroRNA-567 inhibits cell proliferation and induces cell apoptosis in A549 NSCLC cells by regulating cyclin-dependent kinase 8.
genetics_overexpression_promote	33911899	hsa-mir-34a	Glioblastoma	The overexpression of MAFG-AS1 promoted the progression of GBM in vivo by promoting the proliferation of GBM cells while miR-34a reversed the effect of overexpression of MAFG-AS1.
circulation_biomarker_diagnosis_ns	33911894	hsa-mir-155	Ischemic Stroke	SUBJECTS AND METHODS: The relative expression of serum miR-155 and mRNAs (JAK2/STAT3) was assessed using RT-PCR, serum TNF-alpha was measured using ELIZA in 46 acute ischemic stroke patients and 50 control subjects.
lncRNA target	33911865	hsa-mir-27a	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Biliverdin protects against cerebral I/R injury by regulating the miR-27a-3p/Rgs1 axis, thereby inhibiting inflammation and apoptosis.
other	33911724	hsa-mir-17	Dermatitis, Atopic	miR-106b and miR-17 may involve in regulation of immune response in AD patients.
other	33911724	hsa-mir-106b	Dermatitis, Atopic	miR-106b and miR-17 may involve in regulation of immune response in AD patients.
exosome	33911465	hsa-mir-1297	Metabolic Associated Fatty Liver  Disease 	AIM: To figure out the function of lipotoxic exosomal miR-1297 in MAFLD. The lipotoxic hepatocyte-derived exosomal miR-1297 could promote the activation and proliferation of hepatic stellate cells through the PTEN/PI3K/AKT signaling pathway, accelerating the progression of MAFLD.
genetics_knock down_promote	33911345	hsa-mir-384	Nasopharyngeal Carcinoma	Gain- and loss-of-functions of miR-384 were performed to identify its role in NPC progression.
genetics_overexpression_promote	33911148	hsa-mir-138	Glioblastoma	Transient overexpression of miR-138 in GBM cells inhibited cell proliferation, cell cycle, migration, and wound healing capability.
transcription factor target	33911114	hsa-mir-29b	Premature Birth	Hsa-miR-29b-3p associated with cognitive function and may be linked with adulthood morbidities in subjects born preterm, possibly through regulation of gene sets related to neurodegenerative diseases and insulin signaling as well as VLDL and triglyceride metabolism.
lncRNA target	33911067	hsa-mir-637	Triple Negative Breast Neoplasms	"Mechanistically, circPSMA1 acted as a ""miRNAs sponge"" to absorb miR-637; miR-637 inhibited TNBC cell migration and metastasis by directly targeted Akt1, which recognized as a key immune-related gene and affected downstream genes beta-catenin and cyclin D1."
transcription factor target	33911065	hsa-mir-1283	Hypertension	This study aimed to explore whether miR-1283 prevents hypertension through targeting ATF4. Therefore, the miR-1283/ATF4 axis may be a target for the prevention and treatment of hypertension.
other	33911004	hsa-mir-223	Endometrial Neoplasms	MiR-223 was significantly up-regulated in urine of endometrial cancers patients (p=0.003).
other	33911004	hsa-mir-200c	Endometrial Neoplasms	Furthermore, let7-i, miR-34a, and miR-200c were significantly down-regulated and miR-424 was up-regulated in obese women.
other	33911004	hsa-mir-34a	Endometrial Neoplasms	Furthermore, let7-i, miR-34a, and miR-200c were significantly down-regulated and miR-424 was up-regulated in obese women.
other	33911004	hsa-mir-424	Endometrial Neoplasms	Furthermore, let7-i, miR-34a, and miR-200c were significantly down-regulated and miR-424 was up-regulated in obese women.
other	33911004	hsa-let-7i	Endometrial Neoplasms	Furthermore, let7-i, miR-34a, and miR-200c were significantly down-regulated and miR-424 was up-regulated in obese women.
transcription factor target	33910926	hsa-mir-181c	Esophageal Squamous Cell Carcinoma	Functionally, the miR-181cd cluster induces the IT-to-MLP transition by suppressing expression of the Meis2 transcription factor, leading to upregulation of a developmental transcription factor, Hmgb3.
circulation_biomarker_prognosis_up	33910842	hsa-mir-378	Hypertrophy, Left Ventricular	CONCLUSION: We observed a statistically significant relationship between miRNA-378 expression levels and LVH, suggesting that circulating miRNA-378 may be used as a novel biomarker to distinguish patients who have LVH from those who do not.
other	33910598	hsa-let-7a	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-let-7c	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-mir-574	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-mir-877	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-let-7f	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-mir-342	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-let-7b	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
other	33910598	hsa-mir-1273f	Carcinoma, Ovarian Epithelial	3p) in EOC patients when compared with healthy subjects.
lncRNA target	33910530	hsa-mir-1275	Breast Neoplasms	Finally, the role of down-regulated miR-1275 on its targets in biological mechanisms of BC cells was identified; including cell growth, proliferation, movement, invasion, metastasis, and apoptosis.
lncRNA target	33910387	hsa-mir-500b	Alzheimer Disease	Linc01278 and ACTG2 were downregulated and miR-500b-5p was upregulated in AD tissues. This linc01278-miR-500b-5p-ACTG2 axis has a potential role in developing diagnostic markers and therapeutic targets for AD.
other	33910165	hsa-mir-98	Ovarian Neoplasms	Analysis of the top ranked miRNAs revealed that the miRNAs, hsa-let-7f, hsa-miR-1237, hsa-miR-98, hsa-miR-933, and hsa-miR-889, were significantly associated with the survival in patients with ovarian cancer.
other	33910165	hsa-mir-933	Ovarian Neoplasms	Analysis of the top ranked miRNAs revealed that the miRNAs, hsa-let-7f, hsa-miR-1237, hsa-miR-98, hsa-miR-933, and hsa-miR-889, were significantly associated with the survival in patients with ovarian cancer.
other	33910165	hsa-mir-1237	Ovarian Neoplasms	Analysis of the top ranked miRNAs revealed that the miRNAs, hsa-let-7f, hsa-miR-1237, hsa-miR-98, hsa-miR-933, and hsa-miR-889, were significantly associated with the survival in patients with ovarian cancer.
other	33910165	hsa-let-7f	Ovarian Neoplasms	Analysis of the top ranked miRNAs revealed that the miRNAs, hsa-let-7f, hsa-miR-1237, hsa-miR-98, hsa-miR-933, and hsa-miR-889, were significantly associated with the survival in patients with ovarian cancer.
other	33910165	hsa-mir-889	Ovarian Neoplasms	Analysis of the top ranked miRNAs revealed that the miRNAs, hsa-let-7f, hsa-miR-1237, hsa-miR-98, hsa-miR-933, and hsa-miR-889, were significantly associated with the survival in patients with ovarian cancer.
genetics_overexpression_promote	33909822	hsa-mir-133b	Esophageal Squamous Cell Carcinoma	KCNQ1OT1 could directly bind to miR-133b and suppress its expression, and miR-133b reversed the effects of KCNQ1OT1 overexpression in ESCC cells. CONCLUSION: KCNQ1OT1 facilitates ESCC progression by sponging miR-133b and activating the EGFR/PI3K/AKT pathway.
other	33909769	hsa-mir-34a	Retinitis	RESULTS: The present study shows that miR-34a and miR-125b are downregulated in a human diabetic heart.
other	33909769	hsa-mir-125b	Retinitis	RESULTS: The present study shows that miR-34a and miR-125b are downregulated in a human diabetic heart.
other	33909742	hsa-mir-210	Bone Diseases	In vitro and in vivo osteogenic and angiogenic experiments showed that the dual drug delivery system (Siv/DPNP/miR-210) exhibited better properties than those of the individual unloaded and single drug-loaded systems and could significantly accelerate the process of bone repair, which provides a novel strategy for the regeneration and repair of bone defects.
other	33909697	hsa-mir-20a	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-24	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-20a	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-24	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-17	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-214	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-199a	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-199a	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-150	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-17	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-150	Diabetes Mellitus	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
other	33909697	hsa-mir-214	Cardiomyopathies	The miRNA expression of miR-17 was up-regulated and miR-24, miR-150, miR-199a, miR-214, and miR-320a were down-regulated in the DCM patients as compared to healthy controls.
lncRNA target	33909326	hsa-mir-424	Liver Neoplasms	XIST silencing inhibited malignant phenotypes of liver cancer cells, while miR
other	33909229	hsa-mir-155	Triple Negative Breast Neoplasms	MiR-155 is highly expressed in TNBC, but its role and potential mechanism in TNBC remain to be elucidated. OBJECTIVE: The aim of this study is to examine the effect of interfering with miRNA-155 on the inflammatory pathway of NLRP 3 in TNBC (MDA-MB-231).
genetics_knock down_suppress	33908218	hsa-mir-210	Sepsis	Moreover, the knockdown of MIR210HG protected against AKI-induced histological changes of kidneys in rats.
circulation_biomarker_diagnosis_ns	33908217	hsa-mir-125b	Jaundice, Obstructive	CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.
circulation_biomarker_diagnosis_ns	33908217	hsa-mir-125b	Liver Injury	CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.
other	33908139	hsa-mir-15a	Pre-Eclampsia	Finally, rescue experiments were conducted to probe regulatory pattern of the LINC00473/miR-15a-5p/LITAF axis in trophoblasts of PE.
circRNA target	33908023	hsa-mir-155	Rhinitis, Allergic	Circ_0067835 effectively inhibited AR response in ILC2s through participation of miR-155/GATA3 axis.
lncRNA target	33907947	hsa-mir-1914	Carcinoma, Hepatocellular	The in vitro inhibition of the miR
transcription factor target	33907880	hsa-mir-4786	Squamous Cell Carcinoma of Head and Neck	Targeting at the miR3p-SELENBP1-KEAP1-NRF2 signaling axis may enhance the efficacy of chemotherapy for OSCC.
genetics_knock down_suppress	33907874	hsa-mir-181a	Diabetic Cardiomyopathies	Finally, KCNQ1OT1 knockdown reduced the expression of PDCD4 via regulating miR-181a-5p and inhibited myocardial inflammation and cardiomyocyte apoptosis in the in vivo DCM model. CONCLUSIONS: Our findings suggest that KCNQ1OT1 and its target gene miR-181a-5p regulate myocardial inflammation and cardiomyocyte apoptosis by modulating PDCD4 in DCM.
transcription factor target	33907846	hsa-mir-27b	Inflammation	Furthermore, FGF21 alleviated hypoxiainduced HPAEC dysfunction and inflammation by inhibiting miR27b expression and thereby promoting PPARgamma expression.
transcription factor target	33907846	hsa-mir-27b	Hypertension, Pulmonary	On the whole, the findings of the present study suggest that FGF21 may serve as a therapeutic target for managing PAH through the miR27bmediated PPARgamma pathway.
lncRNA target	33907842	hsa-mir-525	Thymoma	In summary, this study demonstrates that LOXL1AS1 acts as a sponge that targets miR5255p to promote HSPA9 expression, thereby promoting the growth and invasion and inhibiting apoptosis of thymoma and thymic carcinoma cells.
genetics_knock down_promote	33907817	hsa-mir-29b	Osteochondrodysplasias	RNF138 knockdown significantly rescued the protective effect of miR29b3p inhibitor on HTM cells under oxidative injury.
lncRNA target	33907817	hsa-mir-29b	Glaucoma	However, the role of microRNA29b3p (miR29b3p) in the pathogenesis of glaucoma remains unknown. Our findings demonstrated that miR29b3p was upregulated in a glaucoma model and antagomiR29b3p alleviated the symptoms of glaucoma.
other	33907817	hsa-mir-29	Glaucoma	By establishing a glaucoma rat model, the effects of miR293p in glaucoma were detected in vivo.
genetics_overexpression_promote	33907778	hsa-mir-99a	Squamous Cell Carcinoma of Head and Neck	miR-99a overexpression inhibited OSCC cell proliferation and clone formation, while miR-99a inhibition contributed to decreased proliferation and clone formation ability.
other	33907584	hsa-mir-1226	Osteosarcoma	MicroRNA-1226-3p has a tumor-promoting role in osteosarcoma.
target gene	33907581	hsa-mir-326	Liver Neoplasms	lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR-326/hnRNPA2B1 axis in liver cancer.
other	33907579	hsa-mir-641	Prostatic Neoplasms	circCDR1as/miR-641/XIAP regulatory axis plays a role in the invasion and migration of the prostate cancer PC-3 cell line.
lncRNA target	33907569	hsa-mir-574	Small Cell Lung Carcinoma	5p may act through VIM, which is a key marker of EMT.
target gene	33907567	hsa-mir-133a	Carcinoma, Non-Small-Cell Lung	MicroRNA-133a-3p suppresses malignant behavior of non-small cell lung cancer cells by negatively regulating ERBB2.
genetics_GWAS	33907541	hsa-mir-155	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Importantly, TGF-beta1 and BMP2/4 treatment had inhibitory effects on cell proliferation; however, miR-155 overexpression enabled CD34(+) CML cells to evade the anti-proliferative effects of TGF-beta1 and BMPs.
genetics_overexpression_suppress	33907470	hsa-mir-145	Carcinoma, Hepatocellular	Overexpression of ARF6 circumvented the effects of miR
lncRNA target	33907465	hsa-mir-4715	Lung Neoplasms	3p, targeting 3UTR of XPG, also influences the process of gastrointestinal carcinogenesis, however, the relationships between XPG and miR
lncRNA target	33907435	hsa-mir-25	Diabetic Nephropathies	CONCLUSION: PVT1 inhibits viability, oxidative stress, fibrosis, and inflammation in DN via miR3p/Snail1 axis.
target gene	33907420	hsa-mir-502	Stomach Neoplasms	Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis.
genetics_knock down_promote	33907418	hsa-mir-202	Triple Negative Breast Neoplasms	Meanwhile, overexpression of AXL obviously reversed the inhibitory effects of miR
exosome	33907416	hsa-mir-338	Pancreatic Neoplasms	Exosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway.
target gene	33907415	hsa-mir-1305	Ovarian Neoplasms	LINC00184 Promotes Ovarian Cancer Cells Proliferation and Cisplatin Resistance by Elevating CNTN1 Expression via Sponging miR-1305.
circulation_biomarker_diagnosis_ns	33907298	hsa-mir-21	Acute Kidney Injury	Fourteen studies (20.0%) examined the effect of miRNA-21 in AKI, and meta-analysis demonstrated significant increases in serum creatinine and kidney injury scores with miR-21 antagonism and pre-conditioning. In summary, several miRNAs target kidney function and apoptosis in pre-clinical AKI models, with data suggesting that miRNA-21 may mediate protection and kidney repair.Systematic review registration ID: CRD42019128854.
genetics_GWAS	33907143	hsa-mir-196a-2	Arthritis, Rheumatoid	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
genetics_GWAS	33907143	hsa-mir-196a-2	Lupus Erythematosus, Systemic	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
genetics_GWAS	33907143	hsa-mir-499	Arthritis, Rheumatoid	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
genetics_GWAS	33907143	hsa-mir-146a	Arthritis, Rheumatoid	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
genetics_GWAS	33907143	hsa-mir-146a	Lupus Erythematosus, Systemic	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
genetics_GWAS	33907143	hsa-mir-499	Lupus Erythematosus, Systemic	These findings do not support the genetic association between miR-196a2 rs11614913 and RA/SLE susceptibility, as well as the association of miR-146a rs2910164, miR-146a rs57095329, miR-499 rs3746444 with SLE.
other	33906981	hsa-mir-181a	Aspermia	In human testis samples of azoospermia patients, low level of miR-181a was correlated with defects in the spermatogenic process.
other	33906980	hsa-mir-34c	Vertebral fusion posterior lumbosacral blepharoptosis	MiR-34c-5p expression was higher in rabbit lumbar fusion model and differentiated BMSCs than normal rabbit or BMSCs.
circulation_biomarker_diagnosis_up	33906524	hsa-mir-377	Macular Edema	CONCLUSION: Serum exosomal miR
other	33906322	hsa-mir-155	Uterine Cervical Neoplasms	5p, which are upregulated in LSIL and HSIL, can be consider as predictive biomarkers for the prognosis of cervical cancer patients.<br />.
other	33906322	hsa-mir-92a	Uterine Cervical Neoplasms	5p, which are upregulated in LSIL and HSIL, can be consider as predictive biomarkers for the prognosis of cervical cancer patients.<br />.
other	33906290	hsa-mir-155	Uterine Cervical Neoplasms	The pooled HR of two miRNAs, miRNA-155 and miRNA-224 which were upregulated in cervical cancer tissues was 1.76 (95% CI 1.27-2.45) revealing significant association with overall poor survival.
other	33906290	hsa-mir-224	Uterine Cervical Neoplasms	The pooled HR of two miRNAs, miRNA-155 and miRNA-224 which were upregulated in cervical cancer tissues was 1.76 (95% CI 1.27-2.45) revealing significant association with overall poor survival.
lncRNA target	33906109	hsa-mir-21	Drug Hypersensitivity	In this study, we report the application of an RNA nanotechnology-based platform for the targeted delivery of anti-miR-21 by epidermal growth factor receptor (EGFR) aptamer in vitro to TNBC and chemical-resistant breast cancer cells.
lncRNA target	33906109	hsa-mir-21	Breast Neoplasms	An oncogenic miRNA, miR-21, is highly expressed in triple-negative breast cancer (TNBC) and is associated with tumor proliferation, invasion, carcinogenesis, prognosis, and therapeutic resistance. In this study, we report the application of an RNA nanotechnology-based platform for the targeted delivery of anti-miR-21 by epidermal growth factor receptor (EGFR) aptamer in vitro to TNBC and chemical-resistant breast cancer cells.
lncRNA target	33906109	hsa-mir-21	Triple Negative Breast Neoplasms	Inhibition of miR-21 by RNA nanoparticles suppressed TNBC cell invasion, migration, and colony formation.
transcription factor target	33905870	hsa-mir-145	Pulmonary Disease, Chronic Obstructive	In summary, isoxanthanol prevents Staphylococcus aureus-induced COPD in rats through up-regulation of miR5p and suppression of inflammatory cytokines.
circulation_biomarker_diagnosis_ns	33905821	hsa-mir-208b	Colorectal Neoplasms	We demonstrated that circulating miR-208b is a non-invasive marker for predicting FOLFOX sensitivity in CRC. Our results demonstrate that tumor-secreted miR-208b promotes Treg expansion by targeting PDCD4, and it may be related to a decrease of oxaliplatin-based chemosensitivity in CRC.
transcription factor target	33905668	hsa-mir-92a	Cerebrovascular Disorders	CONCLUSIONS: These findings suggest that alisol A 24-acetate exerts antiapoptotic effects on OGD-induced BMECs through miR-92a-3p inhibition by targeting the Bcl-2 gene, indicating its potential for BMECs protection and as a novel therapeutic agent for the treatment of cerebrovascular disease.
circulation_biomarker_diagnosis_ns	33905318	hsa-mir-142	Spinal Injuries	5p and serum levels of IL-6, TNF-alpha in SCI patients.
circulation_biomarker_diagnosis_ns	33905318	hsa-mir-142	Spinal Cord Injuries	5p and serum levels of IL-6, TNF-alpha in SCI patients.
lncRNA target	33904680	hsa-mir-34a	Breast Neoplasms	Due to the properties of CM, this study assesses the effects of miR-34a related MSC-CM on tumor behavior through the evaluation of migration, invasion, apoptosis, and PDL1 expression in breast cancer cell lines. The results of the present study showed that simultaneous application of miR-34a and MSC-CM can be considered as a new method for changing the cancerous microenvironment; and therefore, as a potential strategy in breast cancer therapy.
transcription factor target	33904674	hsa-mir-223	Asthma	Based on our findings,miR-223 and miR-21 may be considered biomarkers or used for targeted immunotherapies in asthma.
transcription factor target	33904674	hsa-mir-21	Asthma	Based on our findings,miR-223 and miR-21 may be considered biomarkers or used for targeted immunotherapies in asthma.
circulation_biomarker_diagnosis_ns	33904657	hsa-mir-519a	Inflammatory Bowel Diseases	There was no significant difference in the expression of miR-519a in the blood samples of UC and HC.
genetics_overexpression_promote	33904383	hsa-mir-140	Intervertebral Disc Degeneration	3p was under-expressed in the degenerated IVD NP, whereas its overexpression alleviated IDD.
genetics_overexpression_suppress	33904366	hsa-mir-181a	Osteoporosis-pseudoglioma syndrome	Our data also indicated that miR-181a-5p overexpression significantly inhibited ALP activity, and level of OPN, Runx2 and OCN at mRNA and protein level, whereas miR-181a-5p inhibition presented opposite results.
genetics_knock down_suppress	33904112	hsa-mir-424	Acute Lung Injury	CONCLUSION: NEAT1 knockdown alleviated LPS-induced injury of HPAEpiCs by regulating miR5p/MAPK14 axis, which provided a potential therapeutic target for the treatment of ALI.
lncRNA target	33903887	hsa-mir-126	Reperfusion Injury, Hepatic Ischemia	The results suggest that Dex protects hepatocytes from HIRI via regulating MALAT1/miR
lncRNA target	33903707	hsa-let-7a	Obesity, Maternal	The transfection of Let-7a inhibitor in ex-vivo liver slices from the offspring of obese dams restored phospho-AMPKalpha2 levels.
other	33903707	hsa-let-7	Obesity, Maternal	In summary, Let-7a appears to regulate hepatic AMPKalpha2 protein levels and lead to the early hepatic metabolic disturbances in the offspring of obese dams.
genetics_overexpression_promote	33902659	hsa-mir-125b	Aneuploidy	CONCLUSION: These results suggest that aneuploid abortion correlates positively with MAD1 overexpression, which might be caused by insufficient levels of miR-125b.
lncRNA target	33902658	hsa-mir-3074	Triple Negative Breast Neoplasms	Our results suggest that the inhibition of RARalphaS77 phosphorylation by either expressing RARalphaS77A or inhibiting RARalpha's phosphokinase CDK7, can bypass RA stimuli to transactivate tumor-suppressive miR
target gene	33902604	hsa-mir-188	Breast Neoplasms	lncRNA APOC1P1-3 promoting anoikis-resistance of breast cancer cells by specifically binding to miRNA-188-3p to block the inhibition of Bcl-2.
genetics_knock down_suppress	33902591	hsa-mir-432	Carcinoma, Non-Small-Cell Lung	5p depletion offset the impacts of LINC01783 knockdown, and then DLL-1 silence recovered the influence of miR
other	33902589	hsa-mir-655	Urinary Bladder Neoplasms	The VIM-AS1/miR-655/ZEB1 axis modulates bladder cancer cell metastasis by regulating epithelial-mesenchymal transition.
transcription factor target	33902432	hsa-mir-27a	Osteoporosis	It was reported that miR-27a-3p reduced the symptoms of osteoporosis. Thereby, miR-27a-3p might serve as a new target for the treatment of osteoporosis.
other	33902338	hsa-mir-200c	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-7	Metabolic Diseases	Levels of hsa-miR-148a-3p (P = 0.04) and hsa-miR5p (P = 0.04) were elevated in toxic/metabolic disease.
other	33902338	hsa-mir-221	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-148a	Metabolic Diseases	Levels of hsa-miR-148a-3p (P = 0.04) and hsa-miR5p (P = 0.04) were elevated in toxic/metabolic disease.
other	33902338	hsa-mir-29b	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-148a	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-320d	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-375	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
other	33902338	hsa-mir-125b	Exocrine Pancreatic Insufficiency	Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05).
lncRNA target	33902331	hsa-mir-199a	Lung Neoplasms	PVT1 absorbed miR-199a, and miR-199a inhibited caveolin1 expression and thus formed the PVT1/miR-199a/caveolin1 signaling pathway in lung cancer cells. Our study revealed that silencing of the PVT1/miR-199a/caveolin1 signaling pathway affected the role of lentinan in PM2.5-exposed lung cancer cells.
lncRNA target	33902208	hsa-mir-490	Osteosarcoma	Conclusion: Circ_0006948 regulates ATG7 expression through miR
circRNA target	33902207	hsa-mir-217	Colorectal Neoplasms	Conclusion: Silence of circABCB10 can up-regulate the expression of miR-217 to inhibit the proliferation, migration, invasion and growth of subcutaneous xenografts and increase the radiosensitivity of SW480 cells, which reveals the underlying molecular mechanism of colorectal cancer progression and provides a new sensitizing target for clinical radiotherapy of colorectal cancer.
other	33902008	hsa-mir-495	Breast Neoplasms	Combination of the results from expression, survival, correlation analysis and functional experiments analysis demonstrated the link between lncRNA GATA3-AS1/miR3p/CENPU axis and prognosis of breast cancer.
transcription factor target	33901943	hsa-mir-622	Carcinoma, Hepatocellular	Moreover, the cooperator of LIN28A, ZCCHC11, was newly identified as a prognostic and therapeutic target of miR-622 in liver cancer. Together, identification of novel miR-622 target genes revealed common regulation of cooperating genes and outlines the previously unknown oncogenic role of ZCCHC11 in liver cancer.
circulation_biomarker_diagnosis_ns	33901926	hsa-mir-335	Diabetes Mellitus, Type 2	5p and decreased SLC2A4 expression was observed in both T2D blood samples and pancreatic cell lines.
circulation_biomarker_diagnosis_down	33901624	hsa-mir-409	Diabetes Mellitus	RESULTS: Hsa_circ_0054633 was highly expressed and the expression of miR3p was downregulated in serum of DM patients and HG-treated human pancreatic beta cell line NES2Y.
lncRNA target	33901578	hsa-mir-1301	Carcinoma, Renal Cell	In conclusions, SNHG16 promotes ccRCC cell proliferation and suppresses ccRCC cell apoptosis via interaction with miR
genetics_knock down_promote	33901298	hsa-mir-204	Squamous Cell Carcinoma of Head and Neck	5p overexpression markedly inhibited ESCC cell growth, migration and invasion (P < .05).
transcription factor target	33901269	hsa-mir-34a	Intracranial Aneurysm	In conclusion, miR-34a is down-regulated in IAs while CXCR3 is the direct target of miR-34a that regulates phenotypic modulation of VSMCs.
circulation_biomarker_diagnosis_up	33901254	hsa-let-7a	Inflammatory Breast Neoplasms	Together, circulating sEV-derived miR-181b-5p, miR
circulation_biomarker_diagnosis_up	33901254	hsa-mir-222	Inflammatory Breast Neoplasms	Together, circulating sEV-derived miR-181b-5p, miR
lncRNA target	33901015	hsa-mir-139	Liver Failure	In conclusion, silencing lncRNA NEAT1 upregulated the expression of miR-139 through EZH2, leading to the downregulation of PUMA, which alleviated the development of ALF.
other	33901010	hsa-mir-1297	Glioma	Glioma progression appears to be supported DLGAP1-AS1 -promoted activation of the miR-1297/EZH2 axis.
lncRNA target	33901009	hsa-mir-107	Carcinoma, Hepatocellular	Our findings demonstrated that miR-107 downregulation leads to hepatocellular carcinoma cell resistance in HDACi via a cofilindependent molecular mechanism and ROS accumulation.
other	33900636	hsa-mir-34c	Testicular Diseases	In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions.
other	33900636	hsa-mir-34c	isolated cleft palate	In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions. The expressions of miR-34b and miR-34c were examined by qPCR technique, a significant decrease was observed in tissue samples in the CP-treated group.
other	33900636	hsa-mir-34b	Testicular Diseases	In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions. The expression of GDNF, occludin and TGF-beta3 plays an important role in testicular injury caused by CP, and the decrease in the expression of miR-34b/c in tissue samples may be an important marker for the detection of testicular damage.
other	33900636	hsa-mir-34b	isolated cleft palate	The expression of GDNF, occludin and TGF-beta3 plays an important role in testicular injury caused by CP, and the decrease in the expression of miR-34b/c in tissue samples may be an important marker for the detection of testicular damage.
circulation_biomarker_diagnosis_ns	33900534	hsa-mir-124a	Brain Injuries	Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery.
circulation_biomarker_diagnosis_ns	33900534	hsa-mir-124a	Heart Diseases	Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery.
other	33900518	hsa-mir-93	Parkinson Disease	This study aimed at investigating the role of miR-93 in PD and the molecular mechanisms involved. In conclusion, we demonstrate that miR-93 may be involved in PD by regulating the expression of STAT3.
genetics_GWAS	33900350	hsa-mir-483	Carcinoma, Hepatocellular	The data from our study illustrate that miR483-3p promotes HCC metastasis likely through the induction of oxidative stress and uncover a novel role of EGCG for protection against miR483-3p-mediated HCC metastasis via the epigenetic modulation of miR483-3p expression.
lncRNA target	33899983	hsa-mir-126	Axenfeld-Rieger syndrome	5p expression, as well as indirectly inhibiting the expression of VEGFA.
other	33899508	hsa-mir-4721	Hyperlipoproteinemia Type II	miR-4721 and miR-564 downregulate PCSK9 and may be useful to improve lipid profile in FH patients.
other	33899508	hsa-mir-564	Hyperlipoproteinemia Type II	miR-4721 and miR-564 downregulate PCSK9 and may be useful to improve lipid profile in FH patients.
other	33899115	hsa-mir-106b	Esophageal Neoplasms	The results revealed that miR106b3p levels were upregulated, whereas TMG3 levels were downregulated in ESCC tissues.
lncRNA target	33899079	hsa-mir-506	Stomach Neoplasms	In conclusion, our findings revealed that SNHG15 executed oncogenic properties in GC progression through targeting miR5p, which might provide a novel target for the GC treatment.
other	33898875	hsa-mir-122	Carcinoma, Hepatocellular	Moreover, sCDP/DOX/miR-122 displays remarkably increased anti-tumor efficacy in vivo compared to free DOX and sCDP/DOX alone, indicating its great promising in hepatoma therapy.
exosome	33898768	hsa-mir-33a	Colorectal Neoplasms	miR-33a-5p in small extracellular vesicles as non-invasive biomarker for oxaliplatin sensitivity in human colorectal cancer cells.
genetics_overexpression_suppress	33898511	hsa-mir-490	Colonic Neoplasms	However, without overexpression of miRISC components, when treating CC cells with 1,6-hexanediol(1,6-HD), a widely used LLPS inhibitor, the silence effects of miR
genetics_knock down_promote	33898469	hsa-mir-155	Murine Acquired Immunodeficiency Syndrome	miR-155 overexpression also increased CD4(-)CD8(+) subset and decreased CD4(-)CD8(-) subset of MAIT cells.
target gene	33898446	hsa-mir-143	bladder carcinoma	LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1.
transcription factor target	33898415	hsa-mir-155	Cardiomegaly	In conclusion, our data suggest that MKL1 may contribute to pathological hypertrophy via regulating macrophage-derived miR-155 transcription.
exosome	33898323	hsa-mir-494	Carcinoma, Non-Small-Cell Lung	Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway.
exosome	33898109	hsa-mir-181a	Thyroid Cancer, Papillary	In conclusion, exosomal miR-181a from hypoxic PTC cells promotes tumor angiogenesis and growth through MLL3 and DACT2 downregulation, as well as VEGF upregulation.
target gene	33898107	hsa-mir-2355	Pancreatic Neoplasms	TRIM29 alters bioenergetics of pancreatic cancer cells via cooperation of miR-2355-3p and DDX3X recruitment to AK4 transcript.
target gene	33898105	hsa-mir-20b	Lung Neoplasms	Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37.
other	33897883	hsa-mir-146b	Abortion, Habitual	Clinically, expression of miR-146a-5p, miR-146b-5p, and TRAF6 were aberrant in placental villous tissues from patients with RSA, and negative correlations were found between miR-146a-5p/miR-146b-5p and TRAF6 expression levels. Conclusions: Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA.
other	33897883	hsa-mir-146a	Abortion, Habitual	Clinically, expression of miR-146a-5p, miR-146b-5p, and TRAF6 were aberrant in placental villous tissues from patients with RSA, and negative correlations were found between miR-146a-5p/miR-146b-5p and TRAF6 expression levels. Conclusions: Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA.
other	33897771	hsa-mir-93	Melanoma	5p were obviously regulated positively in metastatic melanoma tissues.
other	33897771	hsa-mir-155	Melanoma	5p were obviously regulated positively in metastatic melanoma tissues.
other	33897771	hsa-mir-18a	Melanoma	5p were obviously regulated positively in metastatic melanoma tissues.
transcription factor target	33897713	hsa-mir-486	Arthritis, Rheumatoid	Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR
transcription factor target	33897713	hsa-mir-223	Arthritis, Rheumatoid	Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR
transcription factor target	33897713	hsa-mir-23a	Arthritis, Rheumatoid	Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR
circulation_biomarker_diagnosis_ns	33897448	hsa-mir-150	Diabetic Nephropathies	5p were detected in the serum and urine of patients with DN.
circulation_biomarker_diagnosis_ns	33897064	hsa-mir-27b	Depression	At the same time, correlation analysis didn't reveal a statistically significant relationship between the fluvoxamine efficacy profile evaluated by changes in HAMD scale scores and the miR-27b plasma concentration: r(s) = -0.012, p = 0.63.
circulation_biomarker_diagnosis_ns	33897064	hsa-mir-27b	Alcoholism	At the same time, correlation analysis didn't reveal a statistically significant relationship between the fluvoxamine efficacy profile evaluated by changes in HAMD scale scores and the miR-27b plasma concentration: r(s) = -0.012, p = 0.63.
lncRNA target	33896835	hsa-mir-1208	Carcinoma, Non-Small-Cell Lung	NSCLC cells were transfected with si-PVT1 or miR-1208 inhibitor and then exposed to irradiation.
exosome	33896827	hsa-mir-1468	Carcinoma, Non-Small-Cell Lung	Among them, 4 exosomal miRNAs, miR
exosome	33896827	hsa-mir-23	Carcinoma, Non-Small-Cell Lung	Among them, 4 exosomal miRNAs, miR
other	33896797	hsa-mir-151	Ovarian Neoplasms	In conclusion, this study demonstrated that circ_0007841/miR3p/MEX3C axis exerted important oncogenic functions in ovarian cancer.
circulation_biomarker_diagnosis_ns	33896365	hsa-mir-337	Stomach Neoplasms	Thus, our data suggested hsa_circ_0000117 exhibited oncogene properties in combination with the hsa_circ_0000117/miR3p/STAT3 axis in GC, potentially providing a new therapeutic target for GC.Abbreviations GC: gastric cancer; STAT3: Signal transducer and activator of transcription 3; circRNA: Circular RNA; miRNA: microRNA; DMEM: Dulbecco's modified Eagle's medium; FBS: fetal bovine serum; PVDF: polyvinylidene fluoride; CCK-8: Cell counting kit-8; qRT-PCR: Quantitative real-time PCR; SDS-PAGE: sodium dodecyl sulfate polyacrylamide gel electrophoresis; TNM: TNM Classification of Malignant Tumors; mTOR: mechanistic target of rapamycin; ANOVA: one-way analysis of variance.
genetics_overexpression_promote	33896068	hsa-mir-125b	Pancreatic Carcinoma	Also, overexpression of miR-125b encouraged migration, metastasis, and proliferation of BxPC-3 cells, and suppression reversed it.
circulation_biomarker_prognosis_ns	33895755	hsa-mir-21	Cholecystitis	AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination.
circulation_biomarker_prognosis_ns	33895755	hsa-mir-122	Cholecystitis	AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination.
circulation_biomarker_prognosis_ns	33895755	hsa-mir-122	Choledocholithiasis	AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination.
circulation_biomarker_prognosis_ns	33895755	hsa-mir-21	Choledocholithiasis	AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination.
other	33895495	hsa-mir-345	Lung Neoplasms	Collectively, SOX2-OT/microRNA5p/EGFR is a ceRNA mechanism underlying the malignant transformation of bronchial epithelia exposed to PM(2.5), which improves our understanding of the association between ambient PM(2.5) exposure and the development of lung cancer.
circulation_biomarker_diagnosis_up	33895478	hsa-mir-29a	COVID-19	5p were evaluated in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients, in both the acute and post-acute COVID-19 phase of the disease and healthy groups, by real-time PCR assays.
lncRNA target	33895168	hsa-mir-424	Colorectal Neoplasms	RESULTS: Our analyses of human colorectal cancer immune profiles and tumor-immune cell interactions showed that tumor-secreted EVs containing microRNA miR-424 suppressed the CD28-CD80/86 costimulatory pathway in tumor-infiltrating T cells and dendritic cells, leading to immune checkpoint blockade resistance. Modified tumor-secreted EVs with miR-424 knocked down enhanced T-cell-mediated antitumor immune response in colorectal cancer tumor models and increased the immune checkpoint blockade response.
transcription factor target	33894415	hsa-mir-223	Hyperglycemia	Transthyretin (TTR) has been proved to repress neovascularization in diabetic retinopathy environment by regulating the molecules in and downstream of the STAT-4/miR3p/FBXW7 signal pathway; however, the details of its direct targets are still not well understood.
other	33894361	hsa-mir-14	Jaw Abnormalities	On the other hand, wing malformation was observed in miR-2 and miR-306 agomirs and miR-2 and miR-14 antagomirs, respectively, suggesting their involvement in S.
other	33894361	hsa-mir-2	Jaw Abnormalities	On the other hand, wing malformation was observed in miR-2 and miR-306 agomirs and miR-2 and miR-14 antagomirs, respectively, suggesting their involvement in S.
genetics_knock down_promote	33894312	hsa-mir-34a	Stomach Neoplasms	Functional gain-and-loss experiments indicated that hsa-miR-34a-5p enhances the chemotherapy sensitivity of MDR GC cells by inhibiting SIRT1, P-gp and MRP1.
lncRNA target	33894272	hsa-mir-34a	Ovarian Neoplasms	This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.
lncRNA target	33894272	hsa-mir-21	Ovarian Neoplasms	This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.
lncRNA target	33894272	hsa-mir-16	Ovarian Neoplasms	This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.
lncRNA target	33894272	hsa-mir-125b	Ovarian Neoplasms	This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.
circRNA target	33894003	hsa-mir-195	Squamous Cell Carcinoma of Head and Neck	Taken together, propofol regulated aggressive progression of OSCC via the circ_0005623/miR
lncRNA target	33893997	hsa-mir-124	Prostatic Neoplasms	3p suppressed cell viability, proliferation, migration, invasion and enhanced apoptosis of prostatic carcinoma cells by directly sponging PTGS2 to inhibit the AKT/NF-kappaB pathway.
genetics_overexpression_promote	33893298	hsa-mir-146a	Colorectal Neoplasms	MiR-146a overexpression or miR-146a target inhibition represent therapeutic approaches that limit pathways converging on tumorigenic IL-17 signaling in CRC.
circulation_biomarker_diagnosis_ns	33893248	hsa-mir-202	Reperfusion Injury, Cerebral Ischemia	3p on CIRI, angiogenesis in midbrain tissue, and the release of inflammatory factors (IFs) in the serum were measured using in vivo rat models.
genetics_knock down_promote	33893245	hsa-mir-1246	Leukemia	Then, gain- and loss-of-function assays were performed in LSCs, where LSCs were co-cultured with AML cell-derived EVs to characterize the effects of miR
genetics_knock down_promote	33893245	hsa-mir-1246	Leukemia, Myeloid, Acute	Then, gain- and loss-of-function assays were performed in LSCs, where LSCs were co-cultured with AML cell-derived EVs to characterize the effects of miR
transcription factor target	33893086	hsa-mir-181c	Medulloblastoma	RESULTS: Compared to the PTCH1 tumor, the SUFU tumor demonstrated lower expression of miR-301a-3p and miR-181c-5p, matrix metallopeptidase 11 (MMP11) and OTX2, higher expression of miR5p and corresponding lower expression of its targeted gene, connexin 30 (GJB6).
circulation_biomarker_diagnosis_ns	33893078	hsa-mir-4525	Carcinoma, Renal Cell	Among them, miRNA-4525 was significantly elevated; miRNA-4525 expression was higher in RCC tissue than in the adjacent normal tissue. CONCLUSION: These findings suggest the potential of miRNA-4525 in serum EVs as a novel biomarker for advanced RCC.
other	33893074	hsa-mir-139	Prostatic Neoplasms	CONCLUSION: miR-139 acts as an immune agonist of RIG-1 to enhance IFN-beta response in prostate cancer cells.
circulation_biomarker_diagnosis_ns	33893071	hsa-mir-222	Pancreatic Carcinoma	miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls.
circulation_biomarker_diagnosis_ns	33893071	hsa-mir-130a	Pancreatic Carcinoma	miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls.
circulation_biomarker_diagnosis_ns	33893071	hsa-mir-34a	Pancreatic Carcinoma	miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls.
lncRNA target	33892661	hsa-mir-196a	Stomach Neoplasms	CONCLUSION: In conclusion, this research supported the first evidence that FGD5-AS1 suppressed proliferation and metastasis in gastric cancer by regulating miR-196a-5p/SMAD6/BMP axis and suggested a potential therapeutic candidate for gastric cancer.
lncRNA target	33892399	hsa-mir-543	Adenocarcinoma of Lung	LINC01089 inhibited lung adenocarcinoma cell proliferation and promoted apoptosis via sponging miR-543.
other	33892093	hsa-mir-7	Lung Neoplasms	Mechanistically, circZNF208 upregulated SNCA expression by acting as a sponge of miR5p and subsequently promoted the resistance of NSCLC cells to low linear energy transfer (LET) X-rays.
other	33892093	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	Mechanistically, circZNF208 upregulated SNCA expression by acting as a sponge of miR5p and subsequently promoted the resistance of NSCLC cells to low linear energy transfer (LET) X-rays.
exosome	33891698	hsa-mir-181	Acute Lung Injury	Our results showed that the lncRNA-p21-induced downregulation of miR-181 might suppress epithelial cell apoptosis and alleviate lung tissue injury by upregulating SIRT1 expression, suggesting the potential therapeutic effects of lncRNA-p21 on SALI. In conclusion, we found that the novel lncRNA-p21/miR-181/SIRT1 pathway may play an important role in the progression of SALI, and MSC-derived exosomes may be a new therapeutic strategy for this disease.
lncRNA target	33891564	hsa-mir-580	Carcinoma, Hepatocellular	5p and inhibited CCL2 secretion into tumor microenvironment by decrease the expression of PPARalpha in HCC cells, then inhibited the pro-inflammatory cytokine release from macrophages by regulating the COX-2/PGE2 pathway.
genetics_overexpression_promote	33891267	hsa-mir-506	Osteosarcoma	The promoting effects of FGD5-AS1 overexpression on OSA cell proliferation and migration could be counteracted by miR
other	33891266	hsa-mir-29a	Liver Neoplasms	CONCLUSION: COL4A1 is negatively regulated by XPD-miR-29a-3p axis and promotes liver cancer progression in vitro.
other	33891159	hsa-mir-19b	Antiphospholipid Syndrome	miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome.
other	33891159	hsa-mir-20a	Antiphospholipid Syndrome	Monocyte expression of miR-19b-3p and miR-20a-5p is low in APS, and patients with the lowest microRNA expression presented the highest levels of antiphospholipid antibodies.
genetics_GWAS	33890616	hsa-let-7	Death	In Caenorhabditis elegans, let-7 is a component of the heterochronic (developmental timing) gene regulatory network, and loss-of-function mutations of let-7 result in lethality during the larval to adult transition due to misregulation of the conserved let-7 target, lin-41.
circulation_biomarker_diagnosis_ns	33890321	hsa-mir-28	Mesothelioma	Thus, this study aimed to demonstrate the mesothelioma-inducing potential of chrysotile at the mesothelial cellular level and the function of microRNA-28 in malignantly transformed mesothelial MeT-5A cells. Surprisingly, the content of miR-28 in the blood of mesothelioma patients was higher than that in control subjects.
other	33890321	hsa-mir-28	Neoplasms, Mesothelial	Thus, this study aimed to demonstrate the mesothelioma-inducing potential of chrysotile at the mesothelial cellular level and the function of microRNA-28 in malignantly transformed mesothelial MeT-5A cells.
other	33890137	hsa-mir-9	Leukemia, Megakaryoblastic, Acute	5p, titrating them away from TGF-betaR mRNAs.
other	33890137	hsa-mir-17	Leukemia, Megakaryoblastic, Acute	5p, titrating them away from TGF-betaR mRNAs.
other	33890137	hsa-mir-106	Leukemia, Megakaryoblastic, Acute	5p, titrating them away from TGF-betaR mRNAs.
lncRNA target	33889573	hsa-mir-153	Carcinoma, Hepatocellular	SULF2-induced CAFs attenuated HCC apoptosis by activating the SDF-1/CXCR4/PI3K/AKT signaling pathway and induced EMT through the SDF-1/CXCR4/OIP5-AS1/miR
lncRNA target	33889541	hsa-mir-9	Glioblastoma	Herein, based on a variety of bioinformatics tools for the reverse prediction of target genes associated with the prognosis of GBM, a ceRNA network of AGAP2-AS1-miR5p-MMP2/MMP9 was constructed, and a potential therapeutic target for GBM was identified.
other	33889522	hsa-mir-942	Adenocarcinoma of Lung	circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.
other	33889521	hsa-mir-4633	Carcinoma, Non-Small-Cell Lung	ISOC1 and its intronic miR-4633, both of them could promote NSCLC cell proliferation, migration, invasion, and cell cycle progression.
lncRNA target	33888994	hsa-mir-23a	Squamous Cell Carcinoma of Head and Neck	RESULTS: The up-regulation of ZEB1-AS1 and downregulation of miR-23a-3p (miR-23a) were found in OSCC cancer tissues. CONCLUSION: The newly identified lncRNA ZEB1-AS1 functions as a tumor promoter in OSCC through regulation of miR-23a.
lncRNA target	33888871	hsa-mir-335	Carcinoma, Renal Cell	Here, we show that miR-335, an anti-onco-miRNA, is downregulation in tumor tissue and inhibited ccRCC cell proliferation, invasion, and migration. Together, our study establishes a new miR-335/KDM3A/YAP1 regulation axis, which provided new insight and potential targeting of the metastasized ccRCC.
lncRNA target	33888655	hsa-mir-132	Attention Deficit Disorder with Hyperactivity	3p levels of children with ADHD may be a therapeutic target of the disease.
lncRNA target	33888645	hsa-mir-204	Stomach Neoplasms	3p expression inhibited KRAS expression in HGC-27 cells, and ectopic expression of LINC00514 enhanced KRAS expression.
other	33888045	hsa-mir-21	Hypertension	CONCLUSION: The study results revealed significantly higher miRNA 21 and aldosterone in RH patients than in healthy individuals and newly diagnosed hypertensives.
lncRNA target	33887883	hsa-mir-627	Cicatrix, Hypertrophic	Conclusions: miR-627 expression in human hypertrophic scars is down-regulated; miR-627 can inhibit the proliferation and promote the apoptosis of Fbs in human hypertrophic scar by targeted inhibition of IGF- expression.
genetics_overexpression_suppress	33887878	hsa-mir-125b	Lymphoma, Large B-Cell, Diffuse	The EVcarried miR125b5p reduced the sensitivity of DLBCL cells to rituximab, which was averted by overexpression of TNFAIP3.
other	33887693	hsa-mir-122	Carcinoma, Renal Cell	From monolayer network to three-layer network, hsa-mir-122 is identified as an important molecule in the oncogenesis and progression of ccRCC, offering new strategies to further study of the carcinogenic mechanism of ccRCC.
genetics_overexpression_promote	33887625	hsa-mir-760	Carcinoma, Hepatocellular	RESULTS: We demonstrated that miR-760 overexpression suppressed cell proliferation, migration, and invasion in HCC.
genetics_overexpression_promote	33887588	hsa-mir-124	Colorectal Neoplasms	3p mimics or inhibitor reversed the effects induced by lncRNA-cCSC1 overexpression or silencing on cell proliferation of CRC.
other	33887587	hsa-mir-29c	Stomach Neoplasms	The circACC1/miR-29c-3p/FOXP1 network plays a key role in gastric cancer by regulating cell proliferation.
lncRNA target	33887546	hsa-mir-203a	Nasopharyngeal Carcinoma	Our findings reveal a new type of circRNA, circTRAF3, which acts as an oncogene in NPC and targets miR-203a-3p/AKT3 pathway.
genetics_GWAS	33887464	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	RESULTS: We identified miR-17 as an epigenetic regulator of LKB1 in NSCLC and confirmed targeting of miR-17 to LKB1 3' untranslated region by luciferase reporter assay.
transcription factor target	33887395	hsa-mir-21	Lung Injury	In conclusion, MET/PLGANPS may alleviate RILI by inhibiting the miR-21/TGF-beta1/Smad3 pathway, which would provide a new target for the treatment of radiation-induced lung injury.
transcription factor target	33887325	hsa-mir-218	Porcine Reproductive and Respiratory Syndrome	Taken together, these results demonstrate that PRRSV-induced miR-218 downregulation serves to inhibit the type I interferon response and may provide a novel therapeutic target for treatment of PRRSV and other viral infections.
transcription factor target	33887260	hsa-mir-17	Urinary Bladder Neoplasms	Collectively, our results demonstrate that BBR exerts anti-tumor effects by perturbing JAK1-STAT3 signaling through the upregulation of miR
genetics_knock down_suppress	33887222	hsa-mir-205	Duane Retraction Syndrome	In summary, Malat1 knockdown diminished hRMEC dysfunctions by regulating miR5p/VEGF-A, providing a useful insight for exploring new therapeutic target for DR.
genetics_overexpression_promote	33886809	hsa-mir-629	Osteosarcoma	5p was overexpressed in osteosarcoma tissues and cells, and thereby enhanced cell proliferation and migration.
genetics_knock down_suppress	33886117	hsa-mir-7	Parkinson Disease	CONCLUSIONS: LINC00943 knockdown could attenuate MPP(+)-triggered neuron injury by regulating the miR5p/CXCL12 axis, hinting at a promising therapeutic target for PD treatment.
genetics_overexpression_suppress	33886061	hsa-mir-145	Cardiomegaly	In this study, H9C2 cells were overexpressed with microRNA
genetics_overexpression_promote	33886022	hsa-mir-25	Carcinoma, Hepatocellular	RESULTS: miR-25 was overexpressed in HCC tissue compared with adjacent normal tissue and significantly correlated with a poorer prognosis.
other	33885954	hsa-mir-93	Acute Kidney Injury	NEAT1 might aggravate LPS-induced injury in HK2 cells by regulating miR5p/TXNIP axis, providing a potential therapeutic strategy for sepsis-associated AKI.
other	33885954	hsa-mir-93	Sepsis	NEAT1 might aggravate LPS-induced injury in HK2 cells by regulating miR5p/TXNIP axis, providing a potential therapeutic strategy for sepsis-associated AKI.
genetics_knock down_promote	33885332	hsa-mir-498	Esophageal Neoplasms	Overexpression of miR-498 or knockdown of DNMT3b enhanced the radiosensitivity of EC cells.
other	33885186	hsa-mir-145	Endometrial Neoplasms	3p/TCF4 axis.
lncRNA target	33885171	hsa-mir-185	Prostatic Neoplasms	CONCLUSIONS: These findings suggest that DANCR exerts oncogenic roles in prostate cancer via the miR
exosome	33884828	hsa-mir-338	Carcinoma, Hepatocellular	In conclusion, BMSC-derived exosomal miR
transcription factor target	33884382	hsa-mir-182	Breast Neoplasms	Thus, our integrated functional analysis suggests that miR-182 might lead to a new therapeutic target in BC manifestation.
lncRNA target	33884030	hsa-mir-588	Osteosarcoma	Taken together, these findings indicated that miR-588 may serve as an independent prognostic factor and tumor suppressor in OS.
other	33884013	hsa-mir-103a	Zoonoses	CONCLUSION: To our knowledge, this is the first study to evaluate miR-21 and miR-103a in toxocariasis, which shed light on the fundamental role of it as a biomarker and diagnostic tool.
circulation_biomarker_diagnosis_up	33883934	hsa-mir-194	Wilms Tumor	5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjacent normal tissues and blood collected from 49 WT patients.
genetics_overexpression_promote	33883902	hsa-mir-516b	Esophageal Squamous Cell Carcinoma	MiR-516b-5p overexpression inhibited the proliferation and motility of ESCC cells.
other	33883889	hsa-mir-17	Reperfusion Injury	CONCLUSION: PPF protects the MIRI by modulating the HOTAIR/miR5p/STAT3 axis.
other	33883598	hsa-mir-10b	Celiac Disease	EV membrane protein and non-coding RNA composition are highly specific to the parent cell type; for example, miR-10b is enriched in MSC-EVs relative to CDC-EVs, while Y RNA fragments follow the opposite pattern.
other	33883592	hsa-mir-29	Diabetes Mellitus	In conclusion, our findings suggest that QCSPION could regulate the expression of the miR-29 family, which in turn increases the expression of glucose transporters and IGF-1, thereby reducing diabetic complications.
circRNA target	33883408	hsa-mir-24	Stomach Neoplasms	5p with circ_0049447 proven by luciferase reporter assay indicated that circ_0049447 may inhibit GC by sponging certain miRNA.
circulation_biomarker_diagnosis_down	33883305	hsa-mir-1228	Stomach Neoplasms	miR-1228 was highly expressed in serum exosomes of patients with gastric cancer with a area under ROC curve (AUC) of 0.865.
circRNA target	33882945	hsa-mir-338	Colonic Neoplasms	CONCLUSION: Circ_0055625 repression inhibited the progression and radioresistance of colon cancer by downregulating MSI1 through sponging miR3p.
lncRNA target	33882812	hsa-mir-486	Breast Neoplasms	5p, inhibited H19 lncRNA and ICAM-1 expression and selectively regressed mBC cell aggressiveness.
transcription factor target	33882492	hsa-mir-210	Myocardial Infarction	In short, our results suggest that miR-210 exerts anti-apoptotic and anti-autophagic effects in hypoxic cardiomyocytes, which alleviates myocardial injury in response to hypoxia.
transcription factor target	33882484	hsa-mir-506	Angelman Syndrome	CONCLUSION: MiR3p can promote the proliferation and migration of VSMCs via targeting KLF4, which can probably contribute to the pathogenesis of AS.
genetics_knock down_promote	33882457	hsa-mir-338	Stomach Neoplasms	EED knockdown could restrain the proliferative and invasive abilities of GC cells by inducing miR
target gene	33882369	hsa-mir-451a	Pancreatic Neoplasms	LncRNA CRNDE promotes the progression and angiogenesis of pancreatic cancer via miR-451a/CDKN2D axis.
target gene	33882368	hsa-mir-10b	Breast Neoplasms	FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis.
lncRNA target	33882171	hsa-mir-195	Osteosarcoma	In this research, osteosarcoma biomarker (miRNA-195) was identified by citrate-capped GNP-colorimetric assay. This simple assay helps to quantify the level of miRNA-195 target DNA and to diagnose the osteosarcoma.
genetics_overexpression_promote	33882126	hsa-mir-15a	Urinary Bladder Neoplasms	These promoting effects were also hindered when miR-15a-5p was overexpressed or HMGA2 was silenced in BC cells. In conclusion, exosomal LINC00355 derived from CAFs promotes BC cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis.
genetics_overexpression_suppress	33882027	hsa-mir-370	Squamous Cell Carcinoma of Head and Neck	Based on rescue assays, FoxM1 overexpression or miR-370 downregulation partially recovered the inhibitory effect of MNX1-AS1 silencing on LSCC cells.
other	33881945	hsa-mir-16	Pneumonia, Mycoplasma	MiR-16 interacted with LINC01128, and miR-16 was high-expressed in PE placentae.
lncRNA target	33881703	hsa-mir-365	Diabetic Nephropathies	In addition, it was demonstrated that miR-365 could target BDNF.
exosome	33881681	hsa-mir-671	Myocardial Infarction	This study suggested that adMSC-derived exosomal miR-671 directly targets TGFBR2 and reduces Smad2 phosphorylation to alleviate MI-like symptoms both in vivo and in vitro.
genetics_knock down_suppress	33880997	hsa-mir-449a	Carcinoma, Hepatocellular	circ_LRIG3 knockdown inhibited the progression of HCC cells by sponging miR-449a.
other	33880613	hsa-mir-126	Pituitary Diseases	Low levels of S-miR3p due to endothelial dysfunction may lead to high IP-VEGF-A, which is closely related to complications after CABG.
other	33880613	hsa-mir-126	Peripheral Arterial Disease	Conversely, S-miR3p on day 7 after surgery was lower in patients with PAD than in patients without PAD.
genetics_knock down_suppress	33880596	hsa-mir-149	Squamous Cell Carcinoma of Head and Neck	Furthermore, DLEU1 knockdowninduced inhibition of OSCC cell proliferation was significantly reversed by the miR1495p antagomir. Knockdown of lncRNA DLEU1 reversed the proliferation of OSCC cells via regulation of the miR1495p/CDK6 axis.
genetics_knock down_promote	33880595	hsa-mir-24	Carcinoma, Non-Small-Cell Lung	Of note, overexpression of miR243p markedly abolished the exogenous hsa_circ_0058357induced excessive proliferation, migration and apoptosis resistance of NSCLC cells.
lncRNA target	33880593	hsa-mir-195	Breast Neoplasms	In breast cancer lncRNA FGD5AS1 serve a key role in glycolysis and tumor progression via the miR1955p/NUAK2 axis.
lncRNA target	33880592	hsa-mir-125b	Lupus Erythematosus, Systemic	It was also determined that hsa_circ_0010957 mediated microRNA (miR)125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)18, IL6 and IL17, which are important factors in the process of SLE. In conclusion, increased hsa_circ_0010957 may be involved in SLE pathogenesis via miR125b/STAT3 signaling.
genetics_knock down_promote	33880589	hsa-mir-1294	Carcinoma, Hepatocellular	circ-PRKCI overexpression promoted the viability, invasion and migration of HCCLM3 cells, which was also reversed by the overexpression of miR-1294 and miR
genetics_knock down_promote	33880589	hsa-mir-186	Carcinoma, Hepatocellular	circ-PRKCI overexpression promoted the viability, invasion and migration of HCCLM3 cells, which was also reversed by the overexpression of miR-1294 and miR
lncRNA target	33880581	hsa-mir-5580	Mouth Neoplasms	In addition to the observation that miR55803p promoted the malignant phenotypes of OC, it was also revealed that miR55803p inhibited OC cell viability, proliferation and migration by suppressing LAMC2.
transcription factor target	33880382	hsa-mir-34a	Diabetic Nephropathies	PURPOSE: To explore the regulatory effects of liraglutide on the kidney and liver through the miR-34a/SIRT1 pathway with related factors in diabetic nephropathy (DN) rats. CONCLUSION: Liraglutide, through its effect on the miR-34a/SIRT1 pathway, may have a protective role in the kidney and liver of DN rats.
circulation_biomarker_diagnosis_up	33880375	hsa-mir-720	Diabetes Mellitus, Type 2	In this study, circulating miR-720 was significantly higher in the T2D group than the control group, and miR-270 was positive correlated with FBG, while negatively correlated with FINS.
circulation_biomarker_diagnosis_up	33880375	hsa-mir-270	Diabetes Mellitus, Type 2	In this study, circulating miR-720 was significantly higher in the T2D group than the control group, and miR-270 was positive correlated with FBG, while negatively correlated with FINS.
lncRNA target	33880049	hsa-mir-200c	Opitz GBBB Syndrome, X-Linked	In this work, we aimed to explore the effects of the MALAT1/miR-200c/NRF2 regulatory axis on the pyroptosis and oxidative stress (Oxidative stress, OS) of renal podocytes in high glucose (HG) environment and whether the lipid-lowering drug atorvastatin (AT) can relieve renal OS through this approach. Further, atorvastatin protected MPC-5 cells from cell pyroptosis and downregulated the level of renal OS via attenuating the expression of MALAT1 and miR-200c.
other	33880049	hsa-mir-200c	Diabetes Mellitus	were detected by Western blotting and immunofluorescence, and the mRNA level of caspase-1, GSDMD, NLRP3, NRF2, MALAT1, miR-200c was tested by qRT-PCR. Further, the expression of GSDMD, MALAT1 and miR-200c were increased, while the level of NRF2, HO-1, OS-related indicators, were decreased simultaneously.
other	33879860	hsa-mir-210	Myocardial Ischemia	Finally, we observed the functional restoration of the ischemia/reperfusion-injured heart by maintaining the intercommunication of EVs and cardiovascular cells derived from ASC(miR-210).
other	33879806	hsa-mir-619	Esophageal Squamous Cell Carcinoma	5p showed excellent values of area under the curve (AUC) >/= 0.80 for diagnosing stage I ESCC.
other	33879806	hsa-mir-1273f	Esophageal Squamous Cell Carcinoma	5p showed excellent values of area under the curve (AUC) >/= 0.80 for diagnosing stage I ESCC.
lncRNA target	33879633	hsa-mir-203	Ovarian Neoplasms	Moreover, ITPKA was negatively regulated by miR-203, a microRNA that has been previously reported to be upregulated in ovarian cancer. Taken together, the results of this study demonstrated the tumor suppressive roles of ITPKA in ovarian cancer and provided a good explanation for the oncogenic roles of miR-203.
lncRNA target	33879631	hsa-mir-607	Carcinoma, Non-Small-Cell Lung	Through the above work, we found that hsa_circ_0072309 interacted with miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC.
other	33879548	hsa-mir-219	Prostatic Neoplasms	5p can be used as a biomarker to predict death risk in prostate cancer patients.
target gene	33879126	hsa-mir-539	Osteosarcoma	MiRNA-539 may inhibit the cell proliferation, migration and invasion of osteosarcoma cells and promote the apoptosis of osteosarcoma cells by targeting on TRIAP1.
transcription factor target	33878909	hsa-mir-204	Cognition Disorders	MiR5p could serve as a potential therapeutic target for the lightening of cognitive dysfunction induced by isoflurane.
lncRNA target	33878446	hsa-mir-34a	Carcinoma, Hepatocellular	In conclusion, TET1 is a tumor suppressor in the progression of HCC by regulating the miR-34a/BACH1/p53 axis, and may contribute to the improvement of HCC prognosis and therapy.
circulation_biomarker_diagnosis_ns	33877895	hsa-mir-21	Heart Failure	Conclusion: Circulating miR-21 levels were decreased in HFrEF patients and hematocrit was identified as a factor associated with this abnormality.
lncRNA target	33877664	hsa-mir-155	Brain Ischemia	Regulation of miRNA-155 expression can target neuronal pacing ion channel HCN channel to regulate the release of amino acid transmitters, thereby alleviating the progress of cerebral ischemia.
other	33877554	hsa-mir-766	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-10b	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-542	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-92b	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-1	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-455	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-184	Glioma	3p were significantly down-regulated in GBM.
other	33877554	hsa-mir-206	Glioma	3p were significantly down-regulated in GBM.
lncRNA target	33877318	hsa-mir-1287	Grave Disease	5p axis modulated TGF-beta1-induced increases in cell adhesion factor levels and TED orbital fibroblast activation through EGFR/AKT signaling.
genetics_overexpression_promote	33876722	hsa-mir-411	Pneumonia, Mycoplasma	5p mimic promoted cell proliferation, migration, and invasion, and the plasmid-mediated PTEN overexpression reversed the effect of the miR
circulation_biomarker_diagnosis_ns	33876465	hsa-mir-21	Anaphylaxis	CONCLUSIONS: These findings provide, for the first time, some insights into the anaphylactic miRNA serum profile in children and point to miR
genetics_knock down_promote	33875796	hsa-mir-4646	Stomach Neoplasms	5p, one of Drosha-independent mirtronic miRNA, is aberrant up-regulated in Drosha-low expressed GC and Drosha-knockdown gastric cancer cells.
lncRNA target	33875790	hsa-mir-135a	Hypoxia-Ischemia, Brain	M2 microglia-derived EVs delivered miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibited the activation of NLRP3 inflammasome, thereby reducing neuronal autophagy and ischemic brain injury.
genetics_knock down_promote	33875646	hsa-mir-548c	Triple Negative Breast Neoplasms	5p/miR-548c-3p efficiently promoted the cell proliferation, migration, and invasion suppressed by circBACH2 knockdown in the TNBC cell lines.
genetics_knock down_promote	33875646	hsa-mir-186	Triple Negative Breast Neoplasms	5p/miR-548c-3p efficiently promoted the cell proliferation, migration, and invasion suppressed by circBACH2 knockdown in the TNBC cell lines.
transcription factor target	33875643	hsa-mir-124	Nasopharyngeal Carcinoma	Our previous study demonstrated that miR-124 could target Foxq1 to inhibit NPC metastasis. In conclusion, our results show that Foxq1 is regulated by miR-124 and that it promotes NPC metastasis by inducing VM via the EGFR signaling pathway.
lncRNA target	33875617	hsa-mir-27a	Reperfusion Injury, Cerebral Ischemia	Thus, MiR-27a-3p appears to suppress CI/R injury by targeting FOXO1.
genetics_overexpression_promote	33875577	hsa-mir-181a-2	Sepsis	3p, and overexpression of GJB2 reversed the anti-inflammatory and antiapoptotic effects of miR-181a
genetics_overexpression_promote	33875577	hsa-mir-181a	Sepsis	3p, and overexpression of GJB2 reversed the anti-inflammatory and antiapoptotic effects of miR-181a
lncRNA target	33875234	hsa-mir-29c	Ovarian Neoplasms	CONCLUSION: Our results demonstrate that miR-29c downregulates B7-H3 to inhibit NK-cell exhaustion and associated with glycolysis, which suggest that NK cells may be a new target of anti-B7-H3 therapy in ovarian cancer patients.
other	33874912	hsa-mir-124	Glomerulonephritis, IGA	A multilayer regulatory network was constructed and several hub-DEGs (Tp53, STAT3, Jun, etc.), DEmiRs (miR-124, let-7b, etc.), TFs (NF-kB, etc.), and lncRNAs (HOTAIR, etc.) were introduced as potential factors in the pathogenesis of IgAN.
lncRNA target	33874704	hsa-mir-627	Cicatrix, Hypertrophic	Conclusion: miR-627 can inhibit the proliferation of Fbs in hypertrophic scar by targeting IGF-.
circulation_biomarker_diagnosis_ns	33872218	hsa-mir-503	Atherosclerosis	5p) was enriched in either extracellular vesicles (EVs), secreted by oxidized low-density lipoprotein-treated macrophages, or the EVs from peripheral blood mononuclear cells of atherosclerosis patients.
genetics_overexpression_promote	33871770	hsa-mir-216b	Glioblastoma	Cell proliferation assay showed that MYCNOS and FOXM1 overexpression resulted in an increased proliferation rate of GBM cells, while miR-216b overexpression suppressed cell proliferation.
other	33871591	hsa-mir-186	Cognition Disorders	The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p.
other	33871591	hsa-mir-107	Cognition Disorders	The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p.
other	33871591	hsa-let-7g	Cognition Disorders	The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p.
genetics_knock down_suppress	33871149	hsa-mir-26b	Pancreatic Carcinoma	METHODS: Overexpression or knockdown of CDK14 or miR-26b was generated in pancreatic cancer cell lines and the function of CDK14 and miR-26b on cell phenotype and the Wnt signaling pathway was determined using 3-(4,5-dimethylthiazol
other	33870836	hsa-mir-145	Diabetes Mellitus, Type 2	Conclusions: Functional miR-143/145 variants might influence the risk of T2DM.
genetics_overexpression_promote	33870669	hsa-mir-610	Neuroblastoma	Besides, overexpression of miR-610 hindered NB cell viability and facilitated cell apoptosis, whereas silencing miR-610 led to reverse results.
lncRNA target	33869908	hsa-mir-155	Plaque, Atherosclerotic	5p in foam cell atherosclerosis inhibition.
genetics_knock down_promote	33869780	hsa-mir-205	Acute Kidney Injury	TapSAKI knockdown or miR-205 overexpression alleviated LPS-induced cytotoxicity in HK-2 cells.
lncRNA target	33869780	hsa-mir-205	Sepsis	Our current study suggested that TapSAKI silencing relieved LPS-induced injury in HK-2 cells at least in part by sponging miR-205 and regulating the IRF3 signaling pathway, highlighting a novel understanding for sepsis pathogenesis and a promising target for this disease treatment.
lncRNA target	33869779	hsa-mir-645	Colorectal Neoplasms	Furthermore, circ_0026344 sponged miR-645 to inhibited Akt/mTOR signal pathway in propofol-treated CRC cells.
genetics_knock down_promote	33869744	hsa-mir-195	Squamous Cell Carcinoma of Head and Neck	The effects of LINC00461, miR-195, and HOXA10 on the EMT and chemoresistance of HNSCC cells were analyzed by comprehensive analysis of gain- and loss-of-function techniques.
genetics_knock down_promote	33869743	hsa-mir-224	Triple Negative Breast Neoplasms	5p reversed the effects of MIR503HG overexpression on TNBC cells, while overexpression of HOXA9 reversed the effect of MIR503HG knockdown.
lncRNA target	33869741	hsa-mir-124	Glioma	MicroRNA-124 de-targeted SFV-AM6-124T selectively replicates in glioma cells, and it can infect orthotopic GL261 gliomas when administered intraperitoneally.
other	33869675	hsa-mir-96	Spinal Cord Injuries	In particular, miR-96 provides a promising therapeutic opportunity to improve the outcomes of clinical interventions, including the way SCI injuries are evaluated and treated.
circulation_biomarker_diagnosis_ns	33869627	hsa-mir-21	Prostatic Neoplasms	In mechanism, circSLC8A1 exhibited a direct interaction with miR-21 and displayed as a miRNA sponge to inhibit PCa progression. CONCLUSIONS: CircSLC8A1 functioned as an inhibitor of neoplasm via modulating the miR-21 and might serve as a prospective target for the treatment of PCa.
genetics_overexpression_promote	33869277	hsa-mir-7b	Spinal Cord Injuries	On the contrary, the overexpression of miR-7b-3p upon in vitro oxidative stress condition (mimicking the SCI environment) significantly reduced the expression level of Wipf2, as observed in vivo, confirming it as a direct miR-7b-3p target.
lncRNA target	33869216	hsa-mir-574	Esophageal Squamous Cell Carcinoma	5p/SMAD4 axis in the progression of ESCC and provide emerging therapeutic targets for ESCC patients.
transcription factor target	33869205	hsa-mir-22	Heart Diseases	We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. Our results revealed that targeting miR-22 may become a new strategy for septic cardiomyopathy treatment.
transcription factor target	33869205	hsa-mir-22	Cardiomyopathies	We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. Our results revealed that targeting miR-22 may become a new strategy for septic cardiomyopathy treatment.
exosome	33869178	hsa-mir-3682	Carcinoma, Hepatocellular	CONCLUSION: Our study elucidates that exosomal miR3p attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling and provides novel potential targets for liver cancer therapy.
genetics_overexpression_promote	33869051	hsa-mir-877	Carcinoma, Non-Small-Cell Lung	Followed functional experiments indicated that overexpression of LINC00941 accelerated angiogenesis and NSCLC tumor progression via miR
genetics_overexpression_promote	33868799	hsa-mir-155	Alcoholism	5p level and its overexpression decreased p-IRS1 (ser 307) and increased p-IR (Tyr 1185) levels, and meanwhile inhibited the mTOR signaling pathway.
transcription factor target	33868799	hsa-mir-155	Cardiomyopathy, Alcoholic	We propose that miR-155 may serve as a novel potential therapeutic target for alcoholic heart disease.
lncRNA target	33868788	hsa-mir-372	Liver Neoplasms	In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer.
lncRNA target	33868788	hsa-mir-106	Liver Neoplasms	In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer.
lncRNA target	33868788	hsa-mir-106a	Liver Neoplasms	In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer.
target gene	33868787	hsa-mir-140	Osteosarcoma	miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
target gene	33868783	hsa-mir-4660	Osteosarcoma	MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660.
other	33868612	hsa-mir-21	Stomach Neoplasms	novel biomarkers (miRNA-21 and miRNA-29) could be proposed as potential treatments of gastric cancer
other	33868612	hsa-mir-29	Stomach Neoplasms	novel biomarkers (miRNA-21 and miRNA-29) could be proposed as potential treatments of gastric cancer
lncRNA target	33868482	hsa-mir-126	Sarcoma, Synovial	HOTAIR was highly expressed in SS tissues, wherein it could promote the proliferation, invasion and migration of SS cells by increasing the expression of SDF-1 via miR-126 inhibition.
genetics_GWAS	33868472	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression.
other	33868470	hsa-mir-124	Breast Neoplasms	Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway.
target gene	33868467	hsa-mir-497	Carcinoma, Non-Small-Cell Lung	lncRNA LINC00473 promotes proliferation, migration, invasion and inhibition of apoptosis of non-small cell lung cancer cells by acting as a sponge of miR-497-5p.
transcription factor target	33868233	hsa-mir-210	Inflammation	Induced miR-210 and miR-3570 inhibit inflammatory cytokine production by targeting RIPK2, thereby avoiding excessive inflammation.
transcription factor target	33868233	hsa-mir-570	Inflammation	Induced miR-210 and miR-3570 inhibit inflammatory cytokine production by targeting RIPK2, thereby avoiding excessive inflammation.
genetics_overexpression_promote	33867846	hsa-mir-92b	Inflammation	Looking into the molecular mechanisms of regulation of inflammatory injury by miR-92b, we observed that overexpression of miR-92b restrained TLR4/NF-kappaB by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT)/beta-catenin pathway. Collectively, these findings show that enforced expression of miR-92b alleviates LPS-induced inflammatory injury by activating the PI3K/AKT/beta-catenin pathway via targeting PTEN, suggesting a potential application for miR-92b-based therapy to treat endometritis or other inflammatory diseases.
lncRNA target	33867845	hsa-mir-4485	Fractures, Bone	MicroRNA-4485 (miR-4485), which we found to be upregulated in COVID-19 patients, negatively regulates osteogenic differentiation. Taken together, our findings highlight that up-regulation of miR-4485 is responsible for the suppression of osteogenic differentiation in COVID-19 patients, and TLR-4 is the potential target through which miR-4485 acts, providing a promising target for pro-fracture-healing and anti-osteoporosis therapy in COVID-19 patients.
lncRNA target	33867838	hsa-mir-1	Breast Neoplasms	Taken together, our results elucidate that circMETTL3 promotes breast cancer progression through circMETTL3/miR5p/CDK1 axis.
exosome	33867829	hsa-mir-4709	Glioblastoma	In summary, this study reveals for the first time that low-dose radiation-induced exosomal circ-METRN plays an oncogenic role in glioblastoma progression and radioresistance through miR
transcription factor target	33867828	hsa-mir-128	Kidney Diseases	Taken together, TF exhibits a strong nephroprotective ability to suppress CaOx-induced kidney damage through the recovery of the antioxidant defense system regulated by miR3p/SIRT1 axis.
lncRNA target	33867824	hsa-mir-18a	Breast Neoplasms	In conclusion: our study proved that HHT suppressed breast cancer cell growth and promoted apoptosis mediated by regulating of the miR-18a-3p-AKT-mTOR signaling pathway, HHT may be a promising antitumor agent in breast cancer treatment.
circulation_biomarker_diagnosis_ns	33867822	hsa-mir-1	Myocardial Infarction	Conclusion: The circulating exosomal miR3p after MI inhibited the CM-induced apoptosis and autophagy of renal tubular epithelial cells, and improved the renal function of rats by targeting ATG13 and activating the AKT signaling pathway.
transcription factor target	33867821	hsa-mir-146a	Stomach Neoplasms	Conclusions: miR-146a-5p targets PRSS1 and suppresses the growth and proliferation of MGC803 cells.
genetics_overexpression_promote	33867818	hsa-mir-552	Pancreatic Carcinoma	Functionally, overexpression of miR-552 promoted pancreatic cancer cell migration and inhibition of miR-552 attenuated this phenotype.
genetics_GWAS	33867710	hsa-mir-570	Urinary Bladder Neoplasms	miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls.
genetics_GWAS	33867710	hsa-mir-181a	Urinary Bladder Neoplasms	miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls.
circulation_biomarker_diagnosis_down	33866949	hsa-mir-125a	Multiple Sclerosis, Relapsing-Remitting	5p in the peripheral blood mononuclear cells (PBMCs) of subjects with relapsing-remitting multiple sclerosis (RRMS).
circulation_biomarker_diagnosis_down	33866949	hsa-mir-218	Multiple Sclerosis, Relapsing-Remitting	5p in the peripheral blood mononuclear cells (PBMCs) of subjects with relapsing-remitting multiple sclerosis (RRMS).
lncRNA target	33866896	hsa-mir-125a	Lupus Erythematosus, Systemic	CONCLUSION: Our findings postulate that miR-125a could act as a candidate therapeutic target for its possible regulation of inflammation in jSLE patients.
other	33866227	hsa-mir-138	Subarachnoid Hemorrhage	RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day.
other	33866227	hsa-mir-134	Subarachnoid Hemorrhage	RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day.
other	33866227	hsa-mir-132	Subarachnoid Hemorrhage	RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day.
other	33866193	hsa-let-7f	Coronary Artery Disease	5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition.
other	33866193	hsa-mir-223	Coronary Artery Disease	5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition.
other	33866193	hsa-mir-151a	Coronary Artery Disease	5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition.
other	33866193	hsa-mir-146a	Coronary Artery Disease	5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition.
circulation_biomarker_prognosis_ns	33866108	hsa-mir-375	Esophageal Neoplasms	High circulating miR-375 was associated with a longer OS (p = 0.02) in patients with esophageal adenocarcinoma (EAC). Elevated circulating miR-375 might be a prognostic marker for patients with EAC.
circulation_biomarker_diagnosis_ns	33866108	hsa-mir-200c	Esophageal Neoplasms	Increased circulating miR-200c-3p in GC showed a trend (p = 0.06) towards a shorter OS.
genetics_knock down_promote	33865997	hsa-mir-135a	Hypertension	The SHR-EVs from the miR135a-5p knockdown-treated fibroblasts lost their roles in inhibiting FNDC5 expression and promoting proliferation in VSMCs of both WKY and SHR.
transcription factor target	33865939	hsa-mir-137	Glaucoma	The aim of this study is to investigate the role of miR-137 in glaucoma and illustrate the potential molecular mechanisms. Hence, miR-137 might be used as a novel therapeutic target to treat glaucoma.
genetics_knock down_promote	33865422	hsa-mir-122	Pancreatic Carcinoma	PART1 was found to serve as a molecular sponge of miR-122, and miR-122 inhibition partially reversed the inhibitory phenotypes of PART1 knockdown on pancreatic cancer cells.
genetics_knock down_promote	33865414	hsa-mir-23c	Carcinoma, Hepatocellular	The results of MTT and Transwell assay showed that miR-23c inhibition restored the inhibitory effect of ZEB1-AS1 knockdown on HCC cells proliferation and invasion.
circulation_biomarker_prognosis_ns	33865271	hsa-mir-337	Osteosarcoma	Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR
circulation_biomarker_prognosis_ns	33865271	hsa-mir-3677	Osteosarcoma	Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR
circulation_biomarker_prognosis_ns	33865271	hsa-mir-582	Osteosarcoma	Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR
circulation_biomarker_prognosis_ns	33865271	hsa-mir-484	Osteosarcoma	Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR
circulation_biomarker_diagnosis_ns	33865244	hsa-mir-377	Diabetic Neuropathies	METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN.
circulation_biomarker_diagnosis_ns	33865244	hsa-mir-377	Diabetes Mellitus, Type 2	METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN.
circulation_biomarker_diagnosis_ns	33865244	hsa-mir-216a	Diabetes Mellitus, Type 2	METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN.
circulation_biomarker_diagnosis_ns	33865244	hsa-mir-216a	Diabetic Neuropathies	METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN.
genetics_overexpression_promote	33865032	hsa-mir-33a	Multiple Myeloma	Both high expression of miR-33a-5p and low expression of PIM1 reversed the suppressive effects of LINC01003 overexpression on cell adhesion and viability, and the promoting effect on apoptosis in MM cells.
circulation_biomarker_diagnosis_up	33865015	hsa-mir-200	Pre-Eclampsia	miR-200 family has been shown to be associated with preeclampsia and upregulated in the plasma and placenta of preeclamptic patients.
lncRNA target	33864618	hsa-mir-662	Pancreatic Carcinoma	CONCLUSIONS: Taken together, circ_03955 functions as a tumor promoter through miR-3662/HIF-1alpha axis, which might provide a novel sight for PC treatment.
other	33864612	hsa-mir-217	Asthma	RESULTS: TGF-beta1, GAS5, HDAC4 were up-regulated, while miR-217 was down-regulated in bronchial mucosal tissues of asthmatic children and TGF-beta1-treated BEAS-2B cells. CONCLUSIONS: The lncRNA GAS5/miR-217/HDAC4 axis played an important role in regulating TGF-beta1-induced bronchial epithelial cells injury, thus contributing to asthma.
lncRNA target	33864447	hsa-mir-1a	Bone Diseases	CONCLUSION: Statin causes skeletal injury through induction of miR-1a excessive expression to decrease MAP3K1 gene expression.
transcription factor target	33864383	hsa-mir-147	Arthritis	Anti-miR-147 therapy could alleviate the severity, especially for the synovitis and joint destruction in experimental arthritis.
transcription factor target	33864383	hsa-mir-147b	Arthritis	Also, mRNA sequencing data showed that hsa-miR-147b-3p mimic and ZNF148 siRNA commonly regulated the gene expression of CCL3 and DEPTOR as well as some arthritis and inflammation-related pathways. Taken together, miR-147b-3p contributes to synovial inflammation through repressing ZNF148 in RA and experimental arthritis.
circulation_biomarker_prognosis_ns	33864191	hsa-mir-767	Multiple Myeloma	METHODS: Bone marrow (BM) plasma cells of 86 MM patients (during standard diagnostic procedures) and 30 healthy donors (HDs) (examination of the eligibility for BM transplantation) were obtained, among which circ_0000190 and miR
lncRNA target	33863546	hsa-mir-27a	Osteosarcoma	In summary, our findings report a new molecular mechanism for the miR-27a-3p-mediated Taxol resistance via targeting tumour suppressor, Fbxw7 in osteosarcoma.
transcription factor target	33863396	hsa-mir-223	Shock, Septic	3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future.
transcription factor target	33863396	hsa-mir-29b	Shock, Septic	3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future.
transcription factor target	33863396	hsa-mir-223	Acute Kidney Injury	3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future.
transcription factor target	33863396	hsa-mir-29b	Acute Kidney Injury	3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future.
other	33863336	hsa-mir-29b	Spinal Cord Injuries	Then a SCI-related ceRNA regulatory network including 8 mRNAs of IFNGR1, STAT2, CYBB, NFATC1, FCGR2B, HMOX1, TLR4, and HK2, a lncRNA of RGD1564534, and a miRNA of miR-29b-5p was constructed. Moreover, RGD1564534 may serve as ceRNA by competitively binding to miR-29b-5p to regulate the expression of 8 SCI-related mRNAs.
circulation_biomarker_diagnosis_down	33862668	hsa-mir-93	Tuberculosis, Pulmonary	MATERIALS AND METHODS: Using two different references (U6 and miR-93), we compared the expression levels of potentially important microRNAs in serum of APT patients with healthy individuals using quantitative polymerase chain reaction (qPCR).
transcription factor target	33862560	hsa-mir-25	Uterine Cervical Neoplasms	We conclude that inhibition of miR-25 may upregulate KLF4 expression and regulate cell proliferation and motility in cervical cancer.
circRNA target	33862456	hsa-mir-532	Carcinoma, Hepatocellular	3p, leading to the downregulation of RAB9A and inhibiting cell invasion of HCC cells.
other	33862403	hsa-mir-4299	Periodontitis	RESULTS: The upregulation of miR-199a-5p and downregulation of miR-4299 in gingival tissue was associated with the presence of PD and RA (P < 0.05).
circulation_biomarker_diagnosis_up	33862403	hsa-mir-199a	Periodontitis	MiR-3198, miR-4299 level in GCF and miR-199a-5p level in plasma strongly correlated with PD, demonstrating significant diagnostic performance.
genetics_GWAS	33862181	hsa-mir-155	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	5p.Three different strategies were employed, namely a network-based pipeline, a survival analysis and genetic screening method, and a simulation modeling approach, to assess the oncogenic role of hsa-miR
other	33862068	hsa-mir-155	Lymphoma, T-Cell, Cutaneous	Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with Sezary syndrome.
circulation_biomarker_diagnosis_ns	33860430	hsa-mir-21	Atherosclerosis	We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis.
circulation_biomarker_diagnosis_ns	33860430	hsa-mir-17	Atherosclerosis	We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis.
circulation_biomarker_diagnosis_ns	33860430	hsa-mir-222	Atherosclerosis	We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis.
circulation_biomarker_diagnosis_ns	33860430	hsa-mir-106b	Atherosclerosis	We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis.
circulation_biomarker_diagnosis_ns	33860430	hsa-mir-27a	Atherosclerosis	We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis.
other	33860122	hsa-mir-122	Hepatitis B	After transduction with a lentivirus-encoding microRNA-122, the cell line harboring the highest level of replicon RNA was selected and then treated with anti-HCV compounds to eliminate the replicon RNA.
genetics_overexpression_suppress	33860046	hsa-mir-223	Neuralgia, Postherpetic	3p overexpression (OV) or interference.
lncRNA target	33860034	hsa-mir-543	Intrauterine Adhesion	OBJECTIVE: To explore the function of miR-543 in endometrial cells and the possible mechanism of regulating the occurrence and development of intrauterine adhesion. CONCLUSION: During the formation of intrauterine adhesions, the expression of CDH2, COL16A1, vimentin, and alpha-SMA may be inhibited by the high expression of miR-543, which may affect the degree of fibrosis and collagen content in the intrauterine adhesions, thereby inhibiting the occurrence and development of intrauterine adhesions.
genetics_overexpression_promote	33859925	hsa-mir-520a	Carcinoma, Non-Small-Cell Lung	Upregulation of RRM2 enhanced the malignant behaviors of NSCLCs, but the oncogenic effects of RRM2 were blocked upon miR-520a overexpression.
genetics_overexpression_suppress	33859750	hsa-mir-765	Endometrial Neoplasms	RNA silencing or overexpressing and pharmacologic inhibitors were used to assess the functions of ERbeta/miR-765/PLP2/Notch axis in UCEC cell proliferation and invasion in vivo and in vitro.
exosome	33859745	hsa-mir-125b	Acute Kidney Injury	We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway.
other	33859515	hsa-mir-21	Diabetic Nephropathies	Methods: A total of 136 patients with type 2 DM and 25 healthy subjects were assessed in a cross-sectional study concerning urinary albumin: creatinine ratio (UACR), eGFR, biomarkers of podocyte damage (synaptopodin, podocalyxin) and of proximal tubule (PT) dysfunction (Kidney injury moleculeKIM-1, N-acetyl-D-glucosaminidase-NAG), urinary lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), nuclear-enriched abundant transcript 1 (NEAT1), myocardial infarction-associated transcript (MIAT), taurine-upregulated gene 1 (TUG1), urinary miRNA21, 124, 93, 29a.
other	33859149	hsa-mir-467f	Brain Death	RESULTS: An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with 2 miRNAs, miR-30a-3p, and miR-467f, correlating with the level of LV dysfunction observed after BD.
other	33859149	hsa-mir-467f	Cardiomyopathies	RESULTS: An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with 2 miRNAs, miR-30a-3p, and miR-467f, correlating with the level of LV dysfunction observed after BD.
other	33859055	hsa-mir-21	Pulmonary Fibrosis	5 p expression than those from other patients.
other	33859055	hsa-mir-21	Fibrosis	5 p expression than those from other patients.
other	33858489	hsa-mir-185	Glioma	CONCLUSIONS: Our study identified the SRSF1/circATP5B/miR5p/HOXB5 feedback loop in GSCs.
transcription factor target	33858426	hsa-mir-665	lung squamous cell carcinoma	Furthermore, miR-665 promoted LUSC cell proliferation through facilitating the Wnt5a/beta-catenin signaling pathway and restrained apoptosis via inhibiting Caspase-3 signaling pathway, whereas TRIM8 suppressed cell growth by repressing the Wnt5a/beta-catenin signaling pathway and induced apoptosis through activating Caspase-3 signaling pathway.
other	33858418	hsa-mir-145	Carcinoma, Hepatocellular	Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma.
circulation_biomarker_diagnosis_up	33858417	hsa-mir-126	Diabetes Mellitus, Type 1	5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively.
circulation_biomarker_diagnosis_up	33858417	hsa-mir-126	Cardiovascular Diseases	5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively.
circulation_biomarker_diagnosis_up	33858417	hsa-mir-126	Inflammation	5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively.
genetics_overexpression_promote	33858324	hsa-mir-192	Carcinoma, Hepatocellular	Moreover, overexpression of miR-192 observably inhibited the proliferation and migration of HCC cells, while overexpression of lncRNA XIST showed an opposite effect.
transcription factor target	33858314	hsa-mir-129	Carcinoma, Non-Small-Cell Lung	5p into NSCLC cell lines markedly induced cell apoptosis, DNA injury, cell cycle arrest, and inhibited cell proliferation and colony formation.
circRNA target	33858297	hsa-mir-7	Thyroid Cancer, Papillary	Taken together, silencing of circ-PSD3 hampered the proliferation and invasion of PTC cells via upregulating the inhibitory effect of miR
genetics_overexpression_promote	33857783	hsa-mir-28	Leukemia, Lymphocytic, Chronic, B-Cell	CRNDE overexpression inhibited cell proliferation and promoted apoptosis via miR-28/NDRG2 axis in CLL. In conclusion, our data elaborated that CRNDE expression was regulated by DNA methylation, and the protective effect of CRNDE on CLL was attributed to the inhibition of proliferation in CLL via miR-28/NDRG2 axis.
other	33857584	hsa-mir-363	Kidney Diseases	The obtained results suggest miR3p involvement in the pathophysiology of Cd-induced renal injury in humans and maybe considered for possible interventional therapeutic strategies for Cd-associated kidney damage.
exosome	33857573	hsa-mir-497	Ossification of Posterior Longitudinal Ligament	Herein, this study evaluated the function of bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) delivering miR
lncRNA target	33857357	hsa-mir-26a	Cicatrix, Hypertrophic	LncRNA NORAD/miR-26a could be a potential target for treating HS.
transcription factor target	33857171	hsa-mir-155	Anodontia	pylori eradication, low-dose aspirin (LDA), non-steroidal anti-inflammatory drugs (NSAIDs) and proton-pump inhibitors (PPI) on modification of inflammatory mucosal miRNAs miR-155 and miR-223 in Helicobacter pylori-infected and non-infected subjects.
transcription factor target	33857171	hsa-mir-223	Anodontia	pylori eradication, low-dose aspirin (LDA), non-steroidal anti-inflammatory drugs (NSAIDs) and proton-pump inhibitors (PPI) on modification of inflammatory mucosal miRNAs miR-155 and miR-223 in Helicobacter pylori-infected and non-infected subjects.
other	33857171	hsa-mir-155	Gastritis, Atrophic	Daily LDA as well as regular NSAIDs showed no influence on miRNAs expression both in healthy subjects and patients, while regular PPI intake was associated with lower miR-155 expression in antrum of patients with chronic gastritis independent of density of neutrophils and mononuclear infiltrate.
other	33856606	hsa-mir-221	Leiomyosarcoma	Considering the pulmonary samples, we observed a higher miRNA-221 and a lower miRNA-126 expression in the leiomyosarcoma.
other	33856606	hsa-mir-126	Leiomyosarcoma	Considering the pulmonary samples, we observed a higher miRNA-221 and a lower miRNA-126 expression in the leiomyosarcoma.
transcription factor target	33856598	hsa-mir-34b	Diabetes, Gestational	These findings concluded that miR-34b-3p impaired HUVECs viability and migration in GDM by targeting PDK1, which might provide a novel perspective for the pathogenesis and underlying therapeutic target for GDM.
lncRNA target	33856498	hsa-mir-27a	Pulmonary Arterial Hypertension	Our results demonstrated that during the pathophysiology of PAH, miR-27a, PPARgamma, and ET-1 were cross-inhibited, which indicated that the miR-27a/PPARgamma/ET-1 signaling pathway was dysregulated; in addition, BST could competitively bind to ET-1 receptors and inhibit the miR-27a/PPARgamma/ET-1 signaling pathway, thereby delaying the proliferation of PASMCs and affecting the development of PAH.
genetics_overexpression_promote	33856490	hsa-mir-671	Stomach Neoplasms	5p inhibitors facilitated the proliferation of gastric cancer cells; however, knocking down LINC01207 and the overexpression of miR
transcription factor target	33856081	hsa-mir-138	Hamartoma Syndrome, Multiple	5p inhibits CS-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway.
transcription factor target	33856081	hsa-mir-138	Testicular Diseases	5p inhibits CS-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway.
other	33856026	hsa-mir-495	Acute Kidney Injury	In conclusion, our findings suggested a novel therapeutic axis of SNHG14/miR3p/HIPK1 to treat sepsis-induced AKI.
target gene	33854971	hsa-mir-450a	Stomach Neoplasms	MiR-450a-5p Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion and Promotes Apoptosis via Targeting CREB1 and Inhibiting AKT/GSK-3β Signaling Pathway.
other	33854632	hsa-mir-141	Carcinoma, Non-Small-Cell Lung	3p and ZEB1/ZEB2 relationship.
other	33854632	hsa-mir-141	Colorectal Neoplasms	3p and ZEB1/ZEB2 relationship.
lncRNA target	33854621	hsa-mir-1229	Esophageal Squamous Cell Carcinoma	To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination.
genetics_overexpression_suppress	33854606	hsa-mir-369	Carcinoma, Hepatocellular	More importantly, the ZEB1 siRNA diminished the discrepancy of growth and metastasis capacity between miR-369 overexpression HCC cells and control cells.
genetics_overexpression_suppress	33854606	hsa-mir-369	Liver Neoplasms	More importantly, the ZEB1 siRNA diminished the discrepancy of growth and metastasis capacity between miR-369 overexpression HCC cells and control cells.
target gene	33854603	hsa-mir-573	Pancreatic Neoplasms	MiR-573 suppresses cell proliferation, migration and invasion via regulation of E2F3 in pancreatic cancer.
circulation_biomarker_diagnosis_ns	33854583	hsa-mir-1305	Multiple Myeloma	Exosome-mediated secretion of miR-1305 in MM cells promoted oncogenic activity of hypoxic MM cells and high serum levels of exosomal miR-1305.
epigenetics	33854524	hsa-mir-375	Breast Neoplasms	EZH2 is an upstream regulator of miR-375 through mediating the methylation of STAT3, while FOXO1 is a downstream target mRNA of miR-375 that activates the p53 signaling pathway