code	PMID	miRNA	disease	description
other	36948853	hsa-mir-40	Liver Cirrhosis	MiR-340 mediates the involvement of high mobility group box 1 in the pathogenesis of liver fibrosis
target gene	36948479	hsa-mir-29b	Zika Virus Infection	Zika virus NS1 suppresses VE-cadherin via hsa-miR-29b-3p/DNMT3b/MMP-9 pathway in human brain microvascular endothelial cells.
exosome	36948039	hsa-mir-130b	Wound Healing	ADSCs-derived exosomal H19 accelerates cutaneous wound healing via the miR-130b-3p/PPARγ/STAT3 axis
target gene	36947996	hsa-mir-221	Stomach Neoplasms	Downregulation of miR-221-3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1.
other	36947456	hsa-mir-497	Pancreatic Neoplasms	Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1.
target gene	36947452	hsa-mir-511	Carcinoma, Non-Small-Cell Lung	Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer.
genetics_knock down_suppress	36946780	hsa-mir-449b	Liver Neoplasms	LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis.
target gene	36946346	hsa-mir-155	Neuroblastoma	miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1
target gene	36946310	hsa-mir-6315	Spinal Cord Injuries	miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway.
target gene	36946075	hsa-mir-145	Uterine Cervical Neoplasms	miR-145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC.
circulation_biomarker_diagnosis_ns	36945942	hsa-mir-21	Hypertension, Pulmonary	Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension
circulation_biomarker_diagnosis_ns	36945942	hsa-mir-143	Hypertension, Pulmonary	Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension
target gene	36944545	hsa-mir-515	Stomach Neoplasms	Hsa_circ_0000670 promoted the progression of gastric cancer through the miR-515-5p/SIX1 molecular axis
target gene	36944544	hsa-mir-200b	Retinoblastoma	The effect of lncRNA ADPGK-AS1 on the proliferation and apoptosis of retinoblastoma cells by targeting miR-200b-5p
other	36944116	hsa-mir-425	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-195	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-429	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-218	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-181a	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-9	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-8485	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-215	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-484	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-619	Hepatitis B, Chronic	miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-214	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-16-2	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200b	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-141	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200c	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-130a	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
other	36944116	hsa-mir-200a	Hepatitis B, Chronic	miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy
target gene	36943627	hsa-mir-454	Breast Neoplasms	LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p.
target gene	36943602	hsa-mir-96	Liver Cirrhosis	Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway.
target gene	36943433	hsa-mir-486	Psoriasis	Downregulation of circ_0024028 inhibits IL-22-induced keratinocyte proliferation and migration by miR-486-3p/AKT3 axis
other	36941992	hsa-mir-27b	Neuroblastoma	CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p
exosome	36941991	hsa-mir-93	Osteoarthritis	Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9.
target gene	36941464	hsa-mir-145	Breast Neoplasms	LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-19b	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-16	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-92a	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-15b	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-451a	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-142	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
circulation_biomarker_diagnosis_ns	36941394	hsa-mir-223	Malaria	Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection.
other	36941055	hsa-mir-34a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-146a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-101a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-15a	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-42	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
other	36941055	hsa-mir-125b	Alzheimer Disease	miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis.
target gene	36940068	hsa-mir-188	Atherosclerosis	Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis
other	36939902	hsa-mir-210	Triple Negative Breast Neoplasms	High HIF- 1a, miR-210 and beclin-1 as well as negative Bcl-2 were inversely related to pathologic complete response following NACT.
other	36939397	hsa-mir-146a	Urinary Bladder Neoplasms	Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance
exosome	36939367	hsa-mir-29a	Colorectal Neoplasms	Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier.
target gene	36939239	hsa-mir-140	Ovarian Neoplasms	lncRNA AC005224.4/miR-140-3p/SNAI2 regulating axis facilitates the invasion and metastasis of ovarian cancer through epithelial-mesenchymal transition
exosome	36939028	hsa-mir-29b	Stomach Neoplasms	Intraperitoneal transfer of miR-29b-containing small extracellular vesicles can suppress peritoneal metastases of gastric cancer.
target gene	36938678	hsa-mir-20a	Breast Neoplasms	LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.
target gene	36938448	hsa-mir-1281	Depression	MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1.
target gene	36937888	hsa-mir-490	renal fibrosis	Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p/HMGA2 axis
target gene	36937804	hsa-mir-23a	Pulmonary Disease, Chronic Obstructive	miR-23a-5p and miR-194-3pare important biomarkers for COPD patients with OP (osteoporosis) and may represent novel targets for diagnosis and treatment of COPD patients with OP.
circulation_biomarker_diagnosis_up	36937162	hsa-mir-205	Alopecia Areata	The serum expression of lncRNA HOTAIR was significantly downregulated in AA patients with a p value < 0.001, while the serum expression of both miRNA-205 and TGF-b1 were significantly upregulated in patients.
other	36936522	hsa-mir-29b	Diabetic Cardiomyopathies	Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP
other	36935520	hsa-mir-421	Osteoarthritis	Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.
other	36935173	hsa-mir-9	cervical squamous cell carcinoma	Effects of miR-9-5p on the migration, invasion and epithelial-mesenchymal transition process in cervical squamous cell carcinoma.
target gene	36934373	hsa-mir-28	Lung Neoplasms	Haplotype-GGGT in long non-coding RNA MALAT1 inhibits brain metastatic lung cancer and lymph nodes of lung cancer via the MALAT1/miR-328/KATNB1
exosome	36934264	hsa-mir-107	Carcinoma, Non-Small-Cell Lung	Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5.
target gene	36934152	hsa-mir-85	Liver Cirrhosis	MIAT enhances the activation of HSCs, at least in part, via miR-3085-5p/YAP/EMT signaling pathway.
exosome	36934129	hsa-mir-663a	Diabetic Nephropathies	Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria.
other	36933242	hsa-mir-62	Myocardial Infarction	MicroRNA-362-3p Implicated in Cardioprotection Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing TP53INP2 and Regulating SDF-1/CXCR4 Pathway.
therapeutic target	36933170	hsa-mir-139	Thyroid Neoplasms	miR-139-5p involvement in iodine uptake metabolism and suggests its possible role as a therapeutic target in restoring iodine uptake in RAI-refractory DTC.
target gene	36932454	hsa-mir-15b	Glioblastoma	circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling.
genetics_GWAS	36932446	hsa-mir-26a	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
genetics_GWAS	36932446	hsa-mir-487b	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
genetics_GWAS	36932446	hsa-mir-1	Glioma	A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival.
other	36932387	hsa-mir-127	Carcinoma, Hepatocellular	The circCCAR1/miR-127-5p/WTAP feedback loop enhances the growth and metastasis of HCC.
target gene	36931409	hsa-mir-202	Atherosclerosis	MicroRNA-202-5p-dependent inhibition of Bcl-2 contributes to macrophage apoptosis and atherosclerotic plaque formation.
circulation_biomarker_diagnosis_ns	36931262	hsa-mir-142	Polycystic Ovary Syndrome	circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers
circulation_biomarker_diagnosis_ns	36931262	hsa-mir-598	Polycystic Ovary Syndrome	circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers
genetics_GWAS	36931173	hsa-mir-1	Aortic Aneurysm, Abdominal	The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis.
exosome	36930410	hsa-mir-200b	Carcinoma, Hepatocellular	Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma.
other	36930090	hsa-mir-17	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
other	36930090	hsa-mir-2355	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
other	36930090	hsa-mir-106a	Tuberculosis	CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis.
exosome	36929868	hsa-mir-455	Nasopharyngeal Carcinoma	Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.
circulation_biomarker_diagnosis_ns	36929799	hsa-mir-146a	Diabetes, Gestational	A preliminary integrated analysis of miRNA-mRNA expression profiles reveals a role of miR-146a-3p/TRAF6 in plasma from gestational diabetes mellitus patients
target gene	36929708	hsa-mir-513b	Prostatic Neoplasms	Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.
other	36929702	hsa-mir-142	Nasopharyngeal Carcinoma	MicroRNA-142-5p promotes the proliferation and metastasis of nasopharyngeal carcinoma.
target gene	36929422	hsa-mir-34a	Colorectal Neoplasms	NONHSAG028908.3 sponges miR-34a-5p to promote growth of colorectal cancer via targeting ALDOA.
other	36928742	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway.
target gene	36927769	hsa-mir-409	Carcinoma, Hepatocellular	BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway.
exosome	36927608	hsa-mir-139	Myocardial Infarction	Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway.
genetics_GWAS	36926729	hsa-mir-34a	Ischemic Stroke	Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
other	36926723	hsa-mir-181b	Ischemic Stroke	miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.
target gene	36925075	hsa-mir-27a	Bronchiolitis Obliterans Syndrome	miR-27a-3p alleviates lung transplantation-induced bronchiolitis obliterans syndrome (BOS) via suppressing Smad-mediated myofibroblast differentiation and TLR4-induced dendritic cells maturation.
target gene	36924565	hsa-mir-223	Rhinitis, Allergic	MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7.
target gene	36923408	hsa-mir-155	Sepsis	CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression.
other	36923098	hsa-mir-29b	Squamous Cell Carcinoma of Head and Neck	The lncRNA XIST/miR-29b-3p/COL3A1 axis regulates central carbon metabolism in head and neck squamous cell carcinoma and is associated with poor tumor prognosis.
circulation_biomarker_diagnosis_ns	36923095	hsa-mir-4488	Non-alcoholic Fatty Liver Disease	Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease.
other	36922872	hsa-mir-484	Carcinoma, Hepatocellular	circFOXK2 upregulated the expression of protein FOXK2-142aa to promote LDHA phosphorylation and led to mitochondrial fission by regulating the miR-484/Fis1 pathway, ultimately activating the Warburg effect in HCC.
target gene	36922713	hsa-mir-1236	Ovarian Neoplasms	VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways.
target gene	36920708	hsa-mir-873	Colorectal Neoplasms	Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.
target gene	36920626	hsa-mir-490	Neuroblastoma	Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.
target gene	36920269	hsa-mir-127	Breast Neoplasms	Decreased miR-127 promotes the occurrence of breast cancer via increasing the expression of SPP1.
other	36920046	hsa-mir-637	Carcinoma, Hepatocellular	Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.
target gene	36920044	hsa-mir-193a	Colorectal Neoplasms	Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.
target gene	36919939	hsa-mir-29a	Cerebral Hemorrhage	Mechanism of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage via the miR-29a-3p/ACSL4 axis.
target gene	36919011	hsa-mir-182	Cicatrix, Hypertrophic	MicroRNA-182-5p Inhibits Hypertrophic Scar Formation by Inhibiting the Proliferation and Migration of Fibroblasts via SMAD4 Pathway.
other	36918702	hsa-mir-145	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
other	36918702	hsa-mir-125b	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
other	36918702	hsa-mir-29a	Colorectal Neoplasms	miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer
target gene	36918335	hsa-mir-1224	Keloid	Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p.
target gene	36917423	hsa-mir-204	Endometriosis	Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis.
target gene	36917402	hsa-mir-139	Hepatoblastoma	miR-139-3p/Wnt5A Axis Inhibits Metastasis in Hepatoblastoma.
target gene	36917325	hsa-mir-24-1	Carcinoma, Renal Cell	MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2.
target gene	36916542	hsa-mir-196a	Thyroid Neoplasms	MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells.
target gene	36916303	hsa-mir-592	Ovarian Neoplasms	MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3.
target gene	36916297	hsa-mir-150	Colonic Neoplasms	Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis.
other	36916095	hsa-mir-155	COVID-19	MicroRNA-155 is a main part of proinflammatory puzzle during severe coronavirus disease 2019 (COVID-19).
other	36916086	hsa-mir-17	Pneumonia	Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis.
other	36916084	hsa-mir-23a	Sepsis	ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
exosome	36915886	hsa-mir-93	Urinary Bladder Neoplasms	Exosomal miR-93-5p as an important driver of bladder cancer progression.
target gene	36915750	hsa-mir-101	Gastrointestinal Stromal Tumors	Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1.
other	36915463	hsa-mir-218	Colorectal Neoplasms	Up-regulation of PUM1 by miR-218-5p promotes colorectal tumor-initiating cell properties and tumorigenesis by regulating the PI3K/AKT axis.
other	36915149	hsa-mir-296	Hypertension, Pulmonary	Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling.
target gene	36915137	hsa-mir-34a	Osteoarthritis	Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis.
other	36915125	hsa-mir-200c	Prostatic Neoplasms	CLIC6 and SCNN1A linked to miR-200c-3p had good prognostic potential and provided valuable insights into the pathogenesis of PCa.
target gene	36915121	hsa-mir-148b	Irritable Bowel Syndrome	apigenin dose-dependently abolished the inhibitory effect of IBS-exo on CACO-2 cell autophagy by regulating miR-148b-3p/ATG14 signaling.
target gene	36915057	hsa-mir-124	Endometriosis	PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
target gene	36914604	hsa-mir-31	acute myocardial infarction	LncRNA AC005332.7 Inhibited Ferroptosis to Alleviate Acute Myocardial Infarction Through Regulating miR-331-3p/CCND2 Axis.
exosome	36913799	hsa-mir-125b	Acute Lung Injury	miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury.
target gene	36913151	hsa-mir-619	Pre-Eclampsia	circPTK2 promotes proliferation, migration and invasion of trophoblast cells through the miR-619/WNT7B pathway in preeclampsia.
target gene	36913084	hsa-mir-429	Uterine Cervical Neoplasms	Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway.
target gene	36913076	hsa-mir-128	Prostatic Neoplasms	Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.
exosome	36912495	hsa-mir-196a	Lung Neoplasms	Exosomal miR-196a-5p enhances radioresistance in lung cancer cells by downregulating NFKBIA.
other	36912261	hsa-mir-74a	Pancreatitis	miR-374a-5p was downregulated in samples from AP patients
other	36912070	hsa-mir-61	Carcinoma, Non-Small-Cell Lung	NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
other	36911684	hsa-mir-17	Adenocarcinoma of Lung	LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma.
other	36911413	hsa-mir-203a	Triple Negative Breast Neoplasms	can predict the survival time of TNBC patients
other	36911413	hsa-mir-148b	Triple Negative Breast Neoplasms	can predict the survival time of TNBC patients
target gene	36911384	hsa-mir-129-2	Endometrial Neoplasms	lncRNA XIST/miR-129-2-3p axis targets CCP110 to regulate the proliferation, invasion and migration of endometrial cancer cells.
target gene	36911069	hsa-mir-129	Carcinoma, Non-Small-Cell Lung	5-FU-miR-129 inhibited NSCLC tumor growth and extended survival in vivo without toxic side effects.
other	36910369	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	Decreased expression of hsa-miR-16-1 is remarkable.
other	36910147	hsa-mir-16	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
other	36910147	hsa-mir-29b	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
other	36910147	hsa-mir-210	Pre-Eclampsia	Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-885	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-200c	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-mir-1909	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
circulation_biomarker_diagnosis_ns	36909377	hsa-let-7d	Carcinoma, Ovarian Epithelial	three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs.
other	36909201	hsa-mir-100	Respiratory Distress Syndrome	miR-100 could serve as novel potential therapeutic molecule in the amelioration of ARDS
target gene	36908850	hsa-mir-19	Uterine Cervical Neoplasms	miR-19-3p Targets PTEN to Regulate Cervical Cancer Cell Proliferation, Invasion, and Autophagy.
target gene	36908326	hsa-mir-627	Colorectal Neoplasms	microRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2.
target gene	36908025	hsa-mir-196b	Ovarian Neoplasms	Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.
target gene	36907052	hsa-mir-34a	Triple Negative Breast Neoplasms	MALAT-1 mediates innate and adaptive immune suppression events partially via targeting miR-34a/MICA/B and miR-175p/PD-L1/B7-H4 axes in TNBC patients and cell lines
other	36906874	hsa-mir-137	Prostatic Neoplasms	lncRNA-PCMF1/hsa-miR-137/Twist1 Axis Involved in the EMT Regulation of Prostate Cancer Cells
other	36906716	hsa-mir-195	uterine corpus endometrial carcinoma	miR-195-5P negatively regulated the expression of PSAT1 in UCEC.
target gene	36905560	hsa-mir-79	Glioblastoma	Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma.
target gene	36905464	hsa-mir-20b	Breast Neoplasms	Silibinin had a strong anti-tumorigenic activity through BCL2L11upregulation and MiR-20b down expression
target gene	36905318	hsa-mir-182	Breast Neoplasms	Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription.
other	36905274	hsa-mir-34a	colorectal adenocarcinoma	The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa
other	36905274	hsa-mir-4b	colorectal adenocarcinoma	The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa
other	36902848	hsa-mir-196b	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-195	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-648	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-767	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-181c	Glioblastoma	Possible Effect on Temozolomide Sensitivity
other	36902848	hsa-mir-181d	Glioblastoma	Possible Effect on Temozolomide Sensitivity
target gene	36902482	hsa-mir-29b	Triple Negative Breast Neoplasms	By inhibiting the expression level of miR-29b-3p, it was shown that complex regulatory pathways targeted this transcript in TNBC cells.
other	36902184	hsa-mir-199a	Squamous Cell Carcinoma of Head and Neck	MiR-199a-5p-Regulated SMARCA4 Promotes Oral Squamous Cell Carcinoma Tumorigenesis.
exosome	36902024	hsa-mir-21	Carcinoma, Hepatocellular	Hepatocellular Carcinoma Cell-Derived Exosomal miR-21-5p Induces Macrophage M2 Polarization by Targeting RhoB.
other	36901866	hsa-mir-93	Endometriosis	The expression of miR-30a (p = 0.0018) and miR-93 (p = 0.0052) was significantly upregulated in the eutopic endometrium of women with endometriosis compared to the controls.
other	36901866	hsa-mir-143	Endometriosis	MiR-143 (p = 0.0225) expression also showed a statistical difference between the eutopic endometrium of women with endometriosis and the control group.
other	36901860	hsa-mir-149	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901860	hsa-mir-23b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MIR323B (rs56103835) were associated with protection from gastrointestinal toxicity
other	36901860	hsa-mir-200c	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment.
other	36901860	hsa-mir-499a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment.
other	36901860	hsa-mir-2053	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901860	hsa-mir-938	Precursor Cell Lymphoblastic Leukemia-Lymphoma	rs2505901 (MIR938) was associated with protection from this toxicity
other	36901860	hsa-mir-605	Precursor Cell Lymphoblastic Leukemia-Lymphoma	SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity
other	36901760	hsa-mir-483	Pterygium	RT-qPCR gene expression analysis confirmed IGF2 upregulation and demonstrated miR-483 expression in pterygium compared to normal conjunctiva (253.2-fold and 12.47-fold, respectively)
other	36901745	hsa-mir-203a	Osteoarthritis	miR203a-3p displayed a protective role reducing the inflammatory effects
genetics_overexpression_suppress	36901700	hsa-mir-101	Carcinoma, Hepatocellular	HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC.
genetics_overexpression_suppress	36901700	hsa-mir-490	Carcinoma, Hepatocellular	HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC.
circulation_biomarker_diagnosis_ns	36899831	hsa-mir-146a	Alzheimer Disease	Alzheimer's Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells.
target gene	36899278	hsa-mir-122	Dyslipidemias	miR-122 dysregulation is associated with type 2 diabetes mellitus-induced dyslipidemia and hyperglycemia independently of its rs17669 variant.
target gene	36899270	hsa-mir-510	Nasopharyngeal Carcinoma	Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis.
target gene	36899199	hsa-mir-139	Esophageal Neoplasms	MiR-139 Affects Radioresistance in Esophageal Cancer by Targeting the PDK1/AKT/Cyclin D1 Signaling Pathway.
exosome	36898846	hsa-mir-885	Stomach Neoplasms	Fusobacterium nucleatum induced exosomal HOTTIP promotes gastric cancer progression through miR-885-3p/EphB2 axis.
target gene	36897170	hsa-mir-424	Osteosarcoma	A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis.
circulation_biomarker_diagnosis_up	36896567	hsa-mir-200c	Carcinoma, Ovarian Epithelial	circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
circulation_biomarker_diagnosis_up	36896567	hsa-mir-200b	Carcinoma, Ovarian Epithelial	circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c.
exosome	36895784	hsa-mir-24	Inflammatory Bowel Diseases	TNF-a Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p.
target gene	36895489	hsa-mir-181a	Colorectal Neoplasms	The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation.
target gene	36894989	hsa-mir-760	Osteoarthritis	MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis.
target gene	36893940	hsa-mir-17	Adenocarcinoma of Lung	CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma.
other	36893709	hsa-mir-133a	Triple Negative Breast Neoplasms	MiR-133a/CD47 axis is a novel prognostic biomarker to promote triple negative breast cancer progression.
other	36892621	hsa-mir-125a	Medulloblastoma	Lower levels of microRNA-125a showed a tendency toward poor survival rates;
target gene	36892495	hsa-mir-152	Ovarian Neoplasms	Evodiamine inhibits malignant progression of ovarian cancer cells by regulating lncRNA-NEAT1/miR-152-3p/CDK19 axis.
target gene	36892025	hsa-mir-515	Stomach Neoplasms	circ_0006089 facilitates gastric cancer progression via decoying miR-515-5p and up-regulating CXCL6.
therapeutic target	36891498	hsa-mir-29b	Muscular Atrophy	small-molecule inhibitor of miR-29b that could act as a potential therapeutic agent for muscle atrophy
other	36890588	hsa-mir-494	Intervertebral Disc Degeneration	miR-494/SIRT3/mitophagy signaling pathway is responsible for the apoptosis and mitochondrial dysfunction of NP cells and that DHJSD may exert protective effects against IVD degeneration by regulating the miR-494/SIRT3/mitophagy signal axis.
target gene	36890438	hsa-mir-218	Atherosclerosis	MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis.
genetics_knock down_promote	36890211	hsa-mir-200b	Colorectal Neoplasms	Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
other	36889776	hsa-mir-195	Uterine Cervical Neoplasms	LncRNA CERS6-AS1 Is a Tumor Promoter in Cervical Cancer by Sponging miR-195-5p.
other	36889771	hsa-mir-525	Carcinoma, Non-Small-Cell Lung	LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP.
target gene	36889769	hsa-mir-26a	Breast Neoplasms	MiR-26a-5p Heightens Breast Cancer Cell Sensitivity to Paclitaxel via Targeting Flap Endonuclease 1.
target gene	36889766	hsa-mir-490	Adenocarcinoma of Lung	MiR-490-3p Sponged by lncRNA NEAT1 Can Attenuate Lung Adenocarcinoma Progression by Suppressing the RhoA/ROCK Signaling Pathway.
target gene	36889764	hsa-mir-118	Colorectal Neoplasms	Long Non-Coding RNA HAND2 Antisense RNA 1 Inhibits Colorectal Cancer Development by Sponging microRNA-3118/Leptin Receptor Axis.
genetics_knock down_suppress	36889763	hsa-mir-70	Uterine Cervical Neoplasms	CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway.
target gene	36889762	hsa-mir-218	Carcinoma, Non-Small-Cell Lung	Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
target gene	36889558	hsa-mir-154	Adenocarcinoma of Lung	LINC00115 regulates lung adenocarcinoma progression via sponging miR-154-3p to modulate Sp3 expression.
target gene	36889174	hsa-mir-152	Colorectal Neoplasms	miR-152-3p facilitates cell adhesion and hepatic metastases in colorectal cancer via targeting AQP11.
therapeutic target	36888755	hsa-mir-766	Sepsis	circPTK2/miR-766/eIF5A axis ameliorates septic ALI, developing a novel therapeutic target for the disease
target gene	36884182	hsa-mir-124	Prostatic Neoplasms	MiR-124-3p inhibits tumor progression in prostate cancer by targeting EZH2.
target gene	36884165	hsa-mir-136	Esophageal Squamous Cell Carcinoma	Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.
other	36883849	hsa-mir-155	Neuroinflammatory Diseases	MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation.
target gene	36882858	hsa-mir-34a	Ototoxicity	miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress.
other	36882799	hsa-mir-146b	Carcinoma, Renal Cell	MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma.
other	36882663	hsa-mir-16	pancreatic adenocarcinoma	The lncRNA PVT1/hsa-miR-16-5p/CASP6/CASP8 regulatory axis plays an vital role in regulating the anti-tumor immune responses for PAAD.
other	36882006	hsa-mir-34a	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36882006	hsa-mir-181a	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36882006	hsa-mir-28	COVID-19	miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19.
other	36881359	hsa-mir-136	Carcinoma, Hepatocellular	Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis.
target gene	36881345	hsa-mir-29b	Osteoporosis	microRNA-29b-3p/sirtuin-1/peroxisome proliferator-activated receptor γ suppress osteogenic differentiation.
target gene	36881338	hsa-mir-1	Colorectal Neoplasms	CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.
target gene	36880587	hsa-mir-24	Osteosarcoma	MicroRNA-324-3p inhibits osteosarcoma progression by suppressing PGAM1-mediated aerobic glycolysis.
target gene	36880288	hsa-mir-128	Alzheimer Disease	MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease.
target gene	36880039	hsa-mir-147b	Stomach Neoplasms	MIR-147B Regulated Proliferation and Apoptosis of Gastric Cancer Cells by Targeting CPEB2 Via the PTEN Pathway.
circulation_biomarker_diagnosis_ns	36879801	hsa-mir-17	Fabry Disease	Exercise-intolerance, blood-lactate increase, and the underlying miR-17/HIF-1 pathway may become useful therapeutic targets and diagnostic/monitoring tools in FD.
other	36879212	hsa-mir-6756	pancreatic ductal adenocarcinoma	LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis.
other	36879212	hsa-mir-4694	pancreatic ductal adenocarcinoma	LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis.
target gene	36879069	hsa-mir-30	Atherosclerosis	miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.
target gene	36878000	hsa-mir-74b	Multiple Sclerosis	MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis
other	36877445	hsa-mir-203a	obsolete Helicobacter pylori infectious disease	H. pylori could contribute to the process of carcinogenesis by downregulating miR-203a
target gene	36876834	hsa-mir-29c	esophageal carcinoma	E2F1 Reduces Sorafenib's Sensitivity of Esophageal Carcinoma Cells via Modulating the miR-29c-3p/COL11A1 Signaling Axis.
target gene	36876724	hsa-mir-144	Carcinoma, Non-Small-Cell Lung	Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in non-small cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144.
target gene	36876422	hsa-mir-211	Stomach Neoplasms	LncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
target gene	36874625	hsa-mir-26b	Colorectal Neoplasms	lncRNA HCG11 Promotes Colorectal Cancer Cell Malignant Behaviors via Sponging miR-26b-5p.
circulation_biomarker_diagnosis_ns	36874371	hsa-mir-92a	Ischemic Stroke	Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
circulation_biomarker_diagnosis_ns	36874371	hsa-mir-75	Ischemic Stroke	Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
target gene	36874361	hsa-mir-610	Melanoma	LINC00511 promotes melanoma progression by targeting miR-610/NUCB2.
other	36873400	hsa-mir-21	Atrial Fibrillation	miR-21-5p as a biomarker that reflects the extent of left atrial fibrosis in AF patients.
target gene	36873253	hsa-mir-221	Carcinoma, Non-Small-Cell Lung	TP63 Functions as a Tumor Suppressor Regulated by GAS5/miR-221-3p Signaling Axis in Human Non-Small Cell Lung Cancer Cells.
target gene	36873181	hsa-mir-23b	Pulmonary Fibrosis	A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis.
genetics_knock down_promote	36872771	hsa-mir-29a	Ischemic Stroke	CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
other	36872450	hsa-mir-26b	Eosinophilic Esophagitis	miR-26b-5p deregulated in saliva
other	36872450	hsa-mir-142	Eosinophilic Esophagitis	miR-142-5p deregulated in saliva
other	36872450	hsa-let-7i	Eosinophilic Esophagitis	Let-7i-5p deregulated in saliva
other	36872450	hsa-mir-205	Eosinophilic Esophagitis	miR-205-5p deregulated in saliva
other	36872450	hsa-mir-27b	Eosinophilic Esophagitis	miR-27b-3p deregulated in saliva
other	36871032	hsa-mir-424	Infertility, Male	upregulated miRNA, notably miR-424
target gene	36870548	hsa-mir-5009	Adenocarcinoma of Lung	LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis.
other	36869885	hsa-mir-71a	Testicular Neoplasms	microRNA-371a-3p showed significantly higher expression rates than other markers suggesting its superior clinical usefulness.
circulation_biomarker_diagnosis_ns	36869070	hsa-mir-21	Brain Injuries, Traumatic	Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients.
other	36869031	hsa-mir-136	Endometrial Neoplasms	PVT1/miR-136/Sox2/UPF1 axis regulates the malignant phenotypes of endometrial cancer stem cells.
circulation_biomarker_diagnosis_up	36868502	hsa-mir-1271	Endometriosis	blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group
circulation_biomarker_diagnosis_up	36868502	hsa-mir-490	Endometriosis	blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group
lncRNA target	36867300	hsa-mir-218	Glioma	CircRNA-104718 modulates glioma cell proliferation through the miR
other	36867268	hsa-mir-4428	Adenocarcinoma of Lung	In conclusion, circGRAMD1B is discovered to modulate miR-4428/SOX4/MEX3A axis to further activate PI3K/AKT pathway, finally boosting migration, invasion, and EMT of LUAD cells.
exosome	36866739	hsa-mir-143	Osteosarcoma	Briefly, transfer of exosomal miR1433p confers doxorubicin resistance in osteosarcoma cells.
circulation_biomarker_diagnosis_ns	36865390	hsa-mir-1246	Breast Neoplasms	The expression levels of circulation miR-1246, HOTAIR, and IL-39 could be considered early diagnostic biomarkers in BC patients.
other	36864416	hsa-mir-183	Stomach Neoplasms	"RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression."
other	36864416	hsa-mir-200	Stomach Neoplasms	"RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression."
circulation_biomarker_diagnosis_ns	36864077	hsa-mir-20a	COVID-19	In the present study, serum MiRNA-106a and miRNA-20a were quantified by real time-PCR in 50 COVID-19 patients hospitalized at Minia university hospital and 30 healthy volunteers.
transcription factor target	36863315	hsa-mir-34a	Inflammation	Thus, miR-34a and senescent PDL cells might be promising therapeutic targets for periodontitis in elderly people.
other	36863142	hsa-mir-146a	Osteoarthritis	induced rabbit OA model was established to investigate the therapeutic role of miR-146a-5p in OA.
lncRNA target	36862865	hsa-mir-126	Carcinoma, Ovarian Epithelial	Though in our previous study we found that miR-126 may inhibit proliferation and invasion in EOC cell lines, but in this study patients with elevated miR-126 expression exhibited poor overall survival and relapse free survival.
other	36862332	hsa-mir-1	Pancreatitis	In addition, the method was also utilized to detect the miRNA-31 expression in collected clinical samples from pancreatitis patients and demonstrated that miRNA-31 was upregulated in patients, showing a great promising of the method in clinical application.
circulation_biomarker_diagnosis_ns	36862282	hsa-mir-940	Bulimia Nervosa	The expression patterns of JHDM1D-AS1, miR-940 and ARTN in BC cells were altered by lentivirus infection and plasmid transfection for functional assays on the biological properties of BC cells.
other	36862282	hsa-mir-940	Breast Neoplasms	In this study, we clarified the mechanistic understanding of JHDM1D-AS1-miRARTN ceRNA network in the development of breast cancer (BC).
genetics_overexpression_promote	36862227	hsa-mir-320c	Cartilage Diseases	METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling.
genetics_overexpression_promote	36862227	hsa-mir-320c	Osteoarthritis	METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling.
genetics_overexpression_promote	36862005	hsa-mir-483	Colorectal Neoplasms	Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures (m-colospheres), here we show that the overexpression of microRNA 483-3p (miRNA
genetics_knock down_promote	36861928	hsa-mir-497	Adenocarcinoma of Lung	Also, LINC00511 and SMAD3 were overexpressed, while miR
target gene	36861798	hsa-mir-4660	Triple Negative Breast Neoplasms	(R)-9bMS inhibited the protein synthesis and autophagy of triple negative breast cancer cells via regulating miR-4660/mTOR axis.
transcription factor target	36861382	hsa-mir-192	Diabetic Retinopathy	5p attenuates DR progression by targeting ELAVL1 and reducing PI3Kdelta expression, suggesting a biomarker for the treatment of DR.
circulation_biomarker_diagnosis_ns	36861291	hsa-mir-143	Arthritis	3p and cell factor generation in peripheral blood (PB) of RA sufferers were identified by ELISA or RT-qPCR.
genetics_overexpression_promote	36861149	hsa-mir-1256	Thyroid Cancer, Papillary	Methods The expression of circ_0092315 in papillary thyroid carcinoma cells was examined by real-time fluorescence quantitative PCR.The proliferation and invasion of TPC-1 cells was assessed by CCK-8 and Transwell assays.The protein level of high mobility group A2 (HMGA2) was determined by Western blotting.The regulatory relationship of circ_0092315,microRNA-1256 (miR-1256),and HMGA2 was explored by bioinformatics tools,dual-luciferase reporter assay,real-time fluorescence quantitative PCR,and Western blotting. +++Results circ_0092315 was overexpressed in papillary thyroid carcinoma cells (all P<0.001).circ_0092315 promoted the proliferation and invasion of TPC-1 cells (all P<0.001).The transfection of si-circ_0092315 up-regulated the expression of miR-1256 (P<0.001),and miR-1256 inhibitor up-regulated the protein level of HMGA2 (P<0.001).
other	36860345	hsa-mir-21	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
other	36860345	hsa-mir-584	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
other	36860345	hsa-mir-200a	Adenocarcinoma of Lung	CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD.
circulation_biomarker_prognosis_ns	36860299	hsa-mir-486	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-193b	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-410	Subarachnoid Hemorrhage	The circulating exosomes miR
circulation_biomarker_prognosis_ns	36860299	hsa-mir-369	Subarachnoid Hemorrhage	The circulating exosomes miR
other	36859458	hsa-mir-146a	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
other	36859458	hsa-mir-5001	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
other	36859458	hsa-mir-17	Plaque, Atherosclerotic	We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis.
transcription factor target	36859185	hsa-mir-4739	Breast Neoplasms	Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth.
transcription factor target	36859185	hsa-mir-658	Breast Neoplasms	Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth.
circulation_biomarker_diagnosis_ns	36859176	hsa-mir-155	Obesity	The present study was designed to investigate expression patterns of miR-146a, miR-155, miR-15a, miR-193a, and miR-122 in peripheral blood mononuclear cells (PBMCs) in children who are obese along with their association with metabolic and inflammatory biomarkers.
circulation_biomarker_diagnosis_up	36858407	hsa-mir-155	Arthritis, Rheumatoid	RESULTS: Compared with the normal group, the pain threshold was significantly decreased (P<0.05), and the knee circumference was significantly increased (P<0.05); the synovial tissue of knee joints showed significant hyperplasia, abundant blood flow signal, joint cavity effusion and obvious inflammatory invasion, the pathological score was significantly increased (P<0.05), the expressions of miR-155 mRNA and IL-1beta, IL-17A, TLR4, NF-kappaB p65 proteins were significantly increased (P<0.05), the expressions of SOCS1 mRNA and protein were significantly decreased (P<0.05) in the model group.
lncRNA target	36858024	hsa-mir-124	Brain Injuries, Traumatic	Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI.
lncRNA target	36858024	hsa-mir-124	Parkinson Disease	Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI.
other	36857620	hsa-mir-370	Endometrial Neoplasms	3p /MAPK1 axis.
genetics_overexpression_promote	36857196	hsa-mir-132	Colorectal Neoplasms	3p or overexpressing IGF2BP1 reversed such effects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-27b	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-381	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
circulation_biomarker_diagnosis_ns	36856518	hsa-mir-451a	Urinary Bladder Neoplasms	5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects.
lncRNA target	36856372	hsa-mir-30	Colorectal Neoplasms	5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments.
genetics_overexpression_suppress	36856212	hsa-mir-125b	Osteosarcoma	Modulation of miR-125b-5p and RAB3D levels produced opposite effects on proliferation and migration of osteosarcoma cells, and in cells with overexpression of both miR-125b-5p and RAB3D, the effect of RAB3D on cell proliferation and migration was blocked by miR-125b-5p overexpression (P < 0.05).
lncRNA target	36856205	hsa-mir-506	High Grade Ovarian Neoplasms	3p may affect EMT of ovarian cancer cells by regulating cell migration and invasion via SNAI2, and its expression level has predictive value for HGSOC recurrence.
transcription factor target	36856174	hsa-mir-12200	Osteoporosis, Postmenopausal	The inhibition of miR5p would almost fully alleviate postmenopausal osteoporosis.
lncRNA target	36856174	hsa-mir-12200	Osteoporosis	The inhibition of miR
transcription factor target	36856108	hsa-mir-503	Intervertebral Disc Degeneration	CONCLUSIONS: miR-503 can improve the function and activity of human nucleus pulposus cells of degenerated intervertebral disc by inhibiting Wnt expression.
lncRNA target	36856073	hsa-mir-210	Fetal Hypoxia	TET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia.
lncRNA target	36856073	hsa-mir-210	Uterine Diseases	Together, our study reveals a novel mechanistic link between the miRTET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia.
lncRNA target	36856073	hsa-mir-210	Mitochondrial Diseases	Hypoxia during pregnancy impairs uterine vascular adaptation via microRNA-210 (miR-210)-mediated mitochondrial dysfunction and mitochondrial reactive oxygen species (mtROS) generation.
transcription factor target	36855796	hsa-mir-590	Colonic Neoplasms	After repressing miR3p with G4-CSSD590, the upregulation of CLCA1, B3GNT6 and UGT2A3 inhibited the proliferation and metastasis of colon cancer cells.
other	36855431	hsa-mir-150	Carcinoma, Hepatocellular	CONCLUSION: ZFAS1 is associated with the malignant status and prognosis of patients with hepatocellular carcinoma, and the ZFAS1/miR5p axis is involved in hepatocellular carcinoma progression.
genetics_knock down_promote	36854894	hsa-mir-424	Cholangiocarcinoma	5p reversed the HCG18 knockdown induced suppression on cholangiocarcinoma cancer cells.
other	36854781	hsa-mir-194	Colorectal Neoplasms	Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development.
other	36854781	hsa-mir-378a	Colorectal Neoplasms	Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development.
other	36854749	hsa-mir-200b	Diabetes Mellitus	Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing.
other	36854749	hsa-mir-200b	Wounds and Injuries	Anti-miR-200b delivery to murine injury sites likewise enhanced tissue perfusion, wound closure, and vasculogenic fibroblast contribution to perfused vessels in a FLI1 dependent manner. Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing.
transcription factor target	36853410	hsa-mir-21	Breast Neoplasms	We demonstrate the assay with the detection of target miRNA-21 in total RNA extracted from MCF-7 cancer cells.
lncRNA target	36853001	hsa-mir-10b	Pancreatitis, Chronic	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-let-7a	Pancreatic Carcinoma	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-mir-10b	Pancreatic Carcinoma	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36853001	hsa-let-7a	Pancreatitis, Chronic	Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI).
lncRNA target	36852954	hsa-mir-1	Myotonic Disorders	Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM.
lncRNA target	36852954	hsa-mir-1	Dmd-Associated Dilated Cardiomyopathy	Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM.
target gene	36852950	hsa-mir-485	Adenocarcinoma of Lung	Circ_0070440 modulated LUAD malignant progression and ferroptosis via targeting SLC7A11, implying a significant role of the circ_0070440/miR-485-5p/SLC7A11 axis in the diagnosis and treatment of LUAD.
circulation_biomarker_diagnosis_up	36852944	hsa-mir-296	Coronary Disease	RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS.
circulation_biomarker_diagnosis_down	36852944	hsa-mir-296	Coronary Artery Disease	RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS.
other	36852928	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
other	36852928	hsa-mir-96	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
other	36852928	hsa-mir-183	Carcinoma, Non-Small-Cell Lung	5p) were ruled out.
transcription factor target	36852907	hsa-mir-221	Diabetic Cardiomyopathies	These data suggest that the protection of luteolin against DCM, at least, is related to suppressing JNK/c-Jun-regulated miR-221 and the subsequent blockage of autophagy.
genetics_overexpression_promote	36852794	hsa-mir-16	Glioblastoma	5p ablation and SEPT2 overexpression.
other	36852793	hsa-mir-155	Neuroblastoma	erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004)
other	36852793	hsa-mir-223	Neuroblastoma	erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004)
genetics_overexpression_promote	36852468	hsa-mir-613	Carcinoma, Renal Cell	Furthermore, a rescue assay with AXL overexpression was performed to make a profound study whether miR-613 disturbs RCC proliferation, invasion, and migration through direct regulation of AXL.
lncRNA target	36852402	hsa-mir-3	Angelman Syndrome	Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity.
lncRNA target	36852402	hsa-mir-3	Fluoride Poisoning	Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity.
lncRNA target	36852302	hsa-mir-939	Colonic Neoplasms	Moreover, Fusobacterium nucleatum promotes COAD progression through the miR3p/FUT1/MUC2 axis.
genetics_knock down_promote	36852074	hsa-mir-30	Stomach Neoplasms	A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p.
genetics_knock down_promote	36852074	hsa-mir-34a	Stomach Neoplasms	A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p.
transcription factor target	36852042	hsa-mir-16	Neurogenic Inflammation	It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16.
transcription factor target	36852042	hsa-mir-16	Inflammation	It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16.
therapeutic target	36851875	hsa-mir-541	Thyroid Cancer, Papillary	circNRIP1 can be a prognostic biomarker and therapeutic target for PTC by acting as a sponge for oncogenic miR-541-5p and miR-3064-5p to upregulate PKM2 expression.
circulation_biomarker_diagnosis_up	36851429	hsa-mir-126	Lymphoma	However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine.
other	36851429	hsa-mir-192	Lymphoma	Expression of miR-18b and miR-192 was higher in carcinomas of the small intestine than in those of the large intestine.
circulation_biomarker_diagnosis_up	36851429	hsa-mir-18b	Lymphoma	However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine.
therapeutic target	36848481	hsa-mir-372	Stomach Neoplasms	downregulation of miR-372-5p may be assumed as a possible therapeutic target in treating gastric cancer.
lncRNA target	36848349	hsa-mir-942	Esophageal Squamous Cell Carcinoma	5p/CST1 axis might be a promising target for diagnosis and treatment of ESCC.
other	36848313	hsa-mir-19a	Pulmonary Fibrosis	Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression.
other	36848313	hsa-mir-19a	Lung Neoplasms	Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression.
lncRNA target	36848245	hsa-mir-27a	Cholangiocarcinoma	FoxO signalling was predominantly downregulated by miR-27a-3p in CCA, partially through targeting of FOXO1.
lncRNA target	36848007	hsa-mir-203a	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-16	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-26b	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-335	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
lncRNA target	36848007	hsa-mir-125b	Parkinson Disease	5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD.
genetics_knock down_suppress	36847916	hsa-mir-422a	Osteoporosis	Finally, since adipocytes released a higher amount of miR-422a in culture medium compared to hBMSCs we analyzed the levels of circulating miR-422a in patients with osteoporosis-a condition characterized by increased marrow adiposity-demonstrating that its levels are negatively correlated with T- and Z-scores. Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis.
genetics_knock down_suppress	36847916	hsa-mir-422a	Bone Diseases, Metabolic	Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis.
lncRNA target	36847717	hsa-mir-204	Sciatic Neuropathy	In summary, HAGLR promoted SC proliferation, migration, neurotrophic factor production, and facilitated functional recovery of SNC rats via miR-204/CDK5R1.
other	36847693	hsa-mir-23b	Uterine Cervical Neoplasms	The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells.
genetics_overexpression_promote	36847222	hsa-mir-252	Wounds and Injuries	Notably, co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression, further supporting that Rab6 is a biologically relevant target of miR
other	36847199	hsa-mir-545	Aortic Aneurysm, Abdominal	3p/CKAP4 axis, adding further understanding of the pathogenesis of AAA and a potential therapeutic approach in AAA management.
other	36847071	hsa-mir-142	Colorectal Neoplasms	LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
target gene	36846943	hsa-mir-152	Lung Neoplasms	ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
transcription factor target	36846934	hsa-mir-133b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: miR-133b downregulates FOXL2 by targeting the 3'-UTR of FOXL2, thereby inhibiting cell proliferation, EMT and metastasis induced by the TGF-beta/Smad signaling pathway in NSCLC.
genetics_knock down_suppress	36846012	hsa-mir-188	Angelman Syndrome	RASSF8-AS1 knockdown caused an increase in miR
other	36845968	hsa-mir-455	Osteoarthritis	3p in OA was downregulated, while PTEN was upregulated (P < 0.05) in comparison to healthy chondrocytes (P < 0.05).
target gene	36845963	hsa-mir-222	Breast Neoplasms	MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3.
target gene	36845963	hsa-mir-221	Breast Neoplasms	MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3.
other	36845957	hsa-mir-582	Obesity	5p-Elovl5 network may be disrupted in lipid metabolism and lead to obesity in the offspring of obese dams.
other	36845651	hsa-mir-103a-2	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
other	36845651	hsa-mir-181d	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
other	36845651	hsa-mir-199a	Amyotrophic Lateral Sclerosis	5p, and hsa-miR-181d-5p had a trend to be upregulated.
genetics_overexpression_promote	36845338	hsa-mir-186m	Carcinoma, Non-Small-Cell Lung	In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs.
genetics_overexpression_promote	36845338	hsa-mir-186	Carcinoma, Non-Small-Cell Lung	In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs.
other	36845111	hsa-mir-30	Chilblain lupus	3p contributes to HBV immune escape, which may provide novel insights into the roles of interaction networks among lncRNA, miRNA, and mRNA in HBV immune escape, highlighting potential applications of lnc-AIFM2-1 and CD244 for diagnosis and treatment in CHB.
transcription factor target	36845016	hsa-mir-206	Hypertension, Renal	CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy.
transcription factor target	36845016	hsa-mir-205	Hypertension, Renal	CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy.
lncRNA target	36845011	hsa-mir-9a	Ischemic Stroke	PURPOSE: Present research is aimed at exploring the effect of miR-9a-5p on mitochondrial autophagy and alleviating cellular oxidative stress injury in ischemic stroke. CONCLUSION: miR-9a-5p protects against ischemic stroke by inhibiting OGD/R-induced mitochondrial autophagy and alleviating cellular oxidative stress injury.
exosome	36844871	hsa-mir-1	Stomach Neoplasms	Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients.
exosome	36844871	hsa-mir-375	Stomach Neoplasms	Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients.
target gene	36844868	hsa-mir-613	Carcinoma, Non-Small-Cell Lung	Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization.
exosome	36844629	hsa-mir-187	Breast Neoplasms	Taxol-resistant breast cancer cell-derived exosome-delivered miR-187-5p regulates the growth of breast cancer cells via ABCD2 and Wnt/beta-catenin signaling.
genetics_GWAS	36843628	hsa-mir-26a	Acute Coronary Syndrome	This study aimed to determine the association between genetic (CYP2C19 and P2Y12 polymorphisms) and epigenetic (DNA methylation of CYP2C19 and P2Y12 and miRNA-26a expression) factors and their effects on MACEs among post-PCI patients. This study demonstrated that hypomethylation of CYP2C19 and miRNA-26a upregulation increased the risk of clopidogrel resistance in post-PCI patients, but there was no correlation between clopidogrel resistance and MACEs.
transcription factor target	36843205	hsa-mir-216a	Arthritis, Rheumatoid	These results revealed that the miR-216a-3p/DUSP5 pathway may play a crucial role in the malignant behavior of FLS, which may serve as a new target for the treatment of RA.
other	36842554	hsa-mir-339	Schizophrenia	This study aimed to determine the Role of miRNA- 339-5p in the Regulation of Klotho Gene Expression and its Circulatory Levels in Schizophrenia.
lncRNA target	36841811	hsa-mir-130a	Myocardial Reperfusion Injury	Collectively, our findings suggest that miR-130a regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial IRI.
lncRNA target	36841801	hsa-mir-506	Colorectal Neoplasms	CONCLUSIONS: Our study showed that LINC00543 enhanced EMT of CRC cells through the pre-miR3p/FOXQ1 axis.
other	36841760	hsa-mir-15a	Stomach Neoplasms	Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p.
genetics_overexpression_promote	36841132	hsa-mir-519c	Melanoma	Finally, we showed restoration of miR-519c-3p in NEAT1-overexpressing SK-MEL-5 CDDP Res cells successfully overrode the NEAT1-promoted cisplatin resistance in melanoma from in vitro and in vivo results.
circRNA target	36840946	hsa-mir-421	Prostatic Neoplasms	The rescue assay results for the PC3 and Du145 cell lines demonstrated that circDHRS3 inhibits prostate cancer cell lines' ability to proliferate and metastasize by modulating MEIS2 expression through the circDHRS3/miR-421/MEIS2 axis. Our study indicates that circDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis.
genetics_overexpression_promote	36840697	hsa-mir-431	Colorectal Neoplasms	Additionally, miR-431 suppression or SLC7A11 overexpression overturned circSTIL silencing-mediated cell phenotypes in CRC cells. CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC.
genetics_overexpression_promote	36840487	hsa-mir-450b	Liver Failure, Acute	MDM2 overexpression reversed the repressive effects of elevated miR-450b-5p on ALF.
other	36840403	hsa-mir-146a	Dengue	These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters.
other	36840403	hsa-mir-96	Dengue	These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters.
circulation_biomarker_diagnosis_ns	36836704	hsa-mir-172	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
circulation_biomarker_diagnosis_ns	36836704	hsa-mir-1285	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
circulation_biomarker_diagnosis_up	36836704	hsa-mir-335	Liver Injury	5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR
other	36836631	hsa-mir-194	Acquired Immunodeficiency Syndrome	The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease.
other	36836631	hsa-mir-122	Acquired Immunodeficiency Syndrome	The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease.
other	36835984	hsa-mir-146a	Osteoarthritis	TREM1, LIF, miR146-5a, and GAS5 were identified to be OA-related genes and potential regulatory pathways.
lncRNA target	36835852	hsa-mir-199a	Chondrocyte Hypertrophy	The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation.
lncRNA target	36835852	hsa-mir-199a	Osteoarthritis	The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation.
other	36835336	hsa-mir-155	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
other	36835336	hsa-mir-21	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
other	36835336	hsa-mir-10b	Breast Neoplasms	The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively.
genetics_overexpression_promote	36835287	hsa-mir-193b	Hyperglycemia	Overexpression of hsa-miR-193b-3p under hyperglycemia also resulted in excess accumulation of intracellular lipid droplets in HepG2 cells.
circulation_biomarker_diagnosis_up	36835287	hsa-mir-193b	Metabolic-Associated Fatty Liver Disease	This study supports further research into potential use of microRNA hsa-miR-193b-3p as a possible clinically relevant plasma biomarker for metabolic-associated fatty liver disease (MAFLD) in dysglycemic context.
circulation_biomarker_prognosis_ns	36835272	hsa-mir-411	Atrial Fibrillation	In conclusion, circulating miR5p could be a valuable prognostic biomarker for MACE in AF patients.
other	36835029	hsa-mir-21	Carcinoma, Pancreatic Ductal	In this study, we focused on the expression of miR-21, -96, -196a, -210, and -217 in normal fibroblasts, cancer-associated fibroblasts prepared from a ductal adenocarcinoma of the pancreas, and pancreatic carcinoma cell lines.
other	36834999	hsa-mir-23a	Infertility, Female	Overall, our findings point to MEIS1 as a common transcription repressor of miR-23a and NORHA, and develop the miR-23a/NORHA axis into a small regulatory network regulating GC apoptosis and female fertility.
other	36834756	hsa-mir-21	Head and Neck Neoplasms	Of all miRNAs assessed, only upregulation of miR-21 was consistently shown to be an independent predictor of poor prognosis and may thus serve as a prognostic biomarker in HNSCC.
circulation_biomarker_diagnosis_up	36834570	hsa-mir-21	Carcinoma, Hepatocellular	Upregulation of plasma hsa-miR
other	36833398	hsa-mir-143	Coronary Artery Disease	However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD.
other	36833380	hsa-let-7a-1	Stomach Neoplasms	Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death.
lncRNA target	36833372	hsa-mir-146a	psoriasis 1	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-155	Crohn Disease	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-146a	Crohn Disease	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
lncRNA target	36833372	hsa-mir-155	psoriasis 1	Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant.
other	36833357	hsa-mir-223	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-149	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-196	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-499	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36833357	hsa-mir-155	Arthritis, Rheumatoid	AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population.
other	36831939	hsa-mir-21	Stomach Neoplasms	In the present research work, the state-of-art label-free electrochemical genosensing platform was developed based on the hybridization process in the presence of [Fe(CN)(6)](3-/4-) as an efficient redox probe for sensitive recognition of the miRNA-21 in human gastric cell lines samples.
other	36831894	hsa-mir-425	Glioblastoma	5p showed the highest consistency in an upregulation in all three GSCs.
other	36831695	hsa-mir-92a	Colorectal Neoplasms	HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer.
other	36831632	hsa-mir-21	Prostatic Neoplasms	MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer.
other	36831624	hsa-mir-27a	Breast Neoplasms	This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients.
other	36831624	hsa-mir-196a	Breast Neoplasms	This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients.
other	36831545	hsa-mir-218	Lung Neoplasms	CONCLUSION: Our study highlights the vital role of the miR5p/EGFR signaling pathway in arsenic-induced carcinogenesis and angiogenesis, which may be helpful for the treatment of lung cancer induced by chronic arsenic exposure in the future.
lncRNA target	36831485	hsa-mir-34a	Colorectal Neoplasms	We have previously identified p53 and its target miR-34a, as critical determinants of the effect of hypoxia on colorectal cancer (CRC). Here we characterized the XBP-1(S) transcription factor and its regulator IRE1A as direct, conserved miR-34a targets in CRC cells.
genetics_overexpression_promote	36831315	hsa-mir-181b-2	Malformations of Cortical Development, Group II	As irradiation reduced the viability and proliferation of NSCs, whereas the overexpression of SOX21 restored the impaired cell viability and promoted the proliferation of NSCs, the findings suggest that the radiation-induced interaction of miR-181b3p with SOX21 may play dual roles in microglia and NSCs, respectively, leading to the impairment of brain neurogenesis.
circulation_biomarker_diagnosis_ns	36831306	hsa-mir-451a	Atrial Fibrillation	Receiver operating characteristic curve analysis showed that miR-451a in left atrium plasma could predict atrial fibrillation recurrence after pulmonary vein isolation. Our data suggest that miRNA-451a expression plays an important role in AF recurrence by controlling fibrosis and progression.
other	36831107	hsa-mir-1271	Thoracic Aortic   Dissection	CONCLUSIONS: The hsa_circ_0007386/miR5P/IGF1R/AKT axis may aggravate the progression of TAD by inducing VSMCs apoptosis.
other	36831100	hsa-mir-675	Breast Neoplasms	3p showed the maximal AUC of 1.000.
other	36831100	hsa-let-7	Breast Neoplasms	This study aims to investigate the relative quantification of long non-coding RNA (lncRNA) H19, microRNA (miR) 675-5p, 675-3p, and miR-let 7 in breast cancer patients.
other	36830824	hsa-mir-28	Dry Eye Syndromes	We previously reported anti-miR-328 therapy for dry eye disease (DED).
other	36830652	hsa-mir-106a	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-106a	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-21	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-21	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-146a	Pancreatitis	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36830652	hsa-mir-146a	familial chylomicronemia syndrome	In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control.
other	36829221	hsa-mir-421	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829221	hsa-mir-550a	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829221	hsa-mir-550a-1	Adenocarcinoma Of Esophagus	Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines.
other	36829193	hsa-mir-204	Mucocutaneous Lymph Node Syndrome	5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level.
other	36829193	hsa-mir-524	Mucocutaneous Lymph Node Syndrome	5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level.
other	36829181	hsa-mir-182	Breast Neoplasms	We identified a feedback loop with the composition of miR5p, CMTM7, CTNNA1, CTNNB1 (beta-catenin), and TCF3, which play essential roles in breast cancer progression.
other	36828974	hsa-mir-185	Diabetic Nephropathies	For the first time, we identified circRNA_0017076 as a sponge for miR5p, which regulates STIM1 gene expression and is involved in RIF.
circulation_biomarker_diagnosis_ns	36827064	hsa-mir-17	Carcinoma, Non-Small-Cell Lung	5p levels are significantly increased in the circulating blood of NSCLC patients.
lncRNA target	36827049	hsa-mir-6785	Colorectal Neoplasms	Our study identified and primarily validated the hsa_circ_0046430/miR5p/SRCIN1 regulatory axis impacted on CRC prognosis, suggesting novel biomarkers and therapeutic targets for CRC patients.
genetics_knock down_promote	36826778	hsa-mir-101	Thyroid Cancer, Papillary	3p, and overexpressed HMGB1 almost reverted the inhibitory impacts induced by miR
other	36826008	hsa-mir-146a	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
other	36826008	hsa-mir-215	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
other	36826008	hsa-mir-29a	Colonic Neoplasms	Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis.
genetics_knock down_promote	36825753	hsa-mir-5195	Ovarian Neoplasms	3p significantly suppressed cell proliferation, cell cycle G1/S transition, migration and invasion in OC cell lines (SKOV-3 and OVCAR3), while knockdown of miR
circulation_biomarker_diagnosis_up	36825718	hsa-mir-103	Osteoporosis	METHODS: Plasma samples of 66 OP patients and 66 healthy controls were collected to prepare RNA samples, followed by RT-qPCR to detect the expression of circPRKCI and miR-103.
transcription factor target	36825546	hsa-mir-21	Breast Neoplasms	miR-21 and TGF-beta expression levels showed upregulation in patients with BC and elevated miR-21/TGF-beta levels consistent with the BC stage. This study suggested that miR-21 and MEG-2 can be used as prospective diagnostic biomarkers and emphasized the crucible role of TGF-beta as therapeutic targets for BC.
transcription factor target	36825443	hsa-mir-339	Vasculitis	3p targets the 5'UTR of NFATc3 mRNA to increase the protein level of NFATc3, thereby aggravating the occurrence of vascular inflammation.
lncRNA target	36824247	hsa-mir-217	Asthma	Meanwhile, functional assays and animal experiments demonstrated that lncRNA NEAT1 regulated GATA3 expression through sponge miR-217, thereby regulating Th1/Th2 balance in CD4+T cells in pediatric asthma. CONCLUSION: lncRNA NEAT1/miR-217/GATA3 axis may reveal the immunological mechanism of pediatric asthma, which has potential clinical application value in the future.
target gene	36824234	hsa-mir-885	Stomach Neoplasms	Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis.
other	36823980	hsa-mir-5739	Muscular Diseases	Importantly, abnormal expression of miR-5739 was detected in somatic cells derived from patients with congenital muscle disease.
lncRNA target	36823651	hsa-mir-525	Osteoarthritis	CONCLUSIONS: LINC00313 inhibited the development of OA through regulating miR5p/GDF5 axis.
genetics_knock down_promote	36823512	hsa-mir-139	Carcinoma, Cutaneous, Squamous Cell	5p inhibition reversed the repressive effect of circ_0068631 knockdown on CSCC cell progression.
genetics_overexpression_promote	36820950	hsa-mir-26b	Nasopharyngeal Carcinoma	Differential analysis of miRNA dataset showed that the expression of miR-26b was significantly downregulated in NPC, in agreement with the validation results of nasopharyngeal carcinoma cell lines. MiR-26b downregulation leads to CEP135 overexpression and NF-kappaB pathway activation in NPC, which enhances proliferation, migration, and prevents apoptosis of nasopharyngeal carcinoma cells.
genetics_knock down_promote	36820067	hsa-mir-545	Carcinoma, Non-Small-Cell Lung	circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway.
transcription factor target	36819593	hsa-mir-155	Irritable Bowel Syndrome	5p participated in the pathogenesis of IBS, at least in part by inhibiting CLDN1 and ZO-1 expression, indicating that miR
transcription factor target	36819582	hsa-mir-194	Squamous Cell Carcinoma of Head and Neck	Also, hsa-miR5p was found to contribute to the poor prognosis of OSCC by regulating CHD4 and enhancing tumor anoikis resistance via the PI3K/AKT signaling pathway.
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-21	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-548ar	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819547	hsa-mir-142	Ischemic Stroke	"5p"" was significantly decreased in the peripheral blood of hospital patients."
circulation_biomarker_diagnosis_ns	36819541	hsa-mir-17	Myocardial Infarction	3p was negatively correlated with circ_0049271 in the AMI blood samples.
lncRNA target	36819499	hsa-mir-23a	Ovarian Neoplasms	lncRNA GAS5 also decreases OC progression by upregulating WT1 and attenuating miR-23a, suggesting that it could be an advantageous therapeutic target for OC intervention.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-107	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-379	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-103	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
circulation_biomarker_diagnosis_ns	36818649	hsa-mir-219a-2	Parkinson Disease	5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD.
exosome	36818289	hsa-mir-218	Dmd-Associated Dilated Cardiomyopathy	Mechanistically, we identified the upregulation of miRNA5p in the DCM-Exos as a critical contributor to fibrogenesis.
target gene	36817669	hsa-mir-1286	Lung Neoplasms	MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2.
transcription factor target	36817393	hsa-mir-182	Graves Ophthalmopathy	CONCLUSIONS: ELF3/miR-182/TSHR axis alleviated Graves' orbitopathy by inhibiting adipogenic differentiation.
lncRNA target	36816363	hsa-mir-27a	Colorectal Neoplasms	The direct targeting of miR-27a-3p by ADAMTS9-AS2 abrogated the latter's effect in CRC cells.
other	36816358	hsa-mir-107	Breast Neoplasms	The PTEN/AKT signaling pathway may be regulated by miR-107 to limit breast cancer cell growth and increase apoptosis, which suggests that miR-107 may be exploited as a tumor marker for therapeutic therapy.
target gene	36816357	hsa-mir-155	Carcinoma, Hepatocellular	LncRNA CASC2 Regulate Cell Proliferation and Invasion by Targeting miR-155/SOCS1 Axis in Hepatocellular Carcinoma.
genetics_overexpression_suppress	36815970	hsa-mir-191	Adenomyosis	MIR503HG directly targeted miR-191 that was highly expressed in endometrial tissues derived from patients with AD. Collectively, overexpressed MIR503HG impeded the proliferation and migration of ESCs derived from endometrium of patients with AD, while promoting apoptosis via inhibition of the Wnt/beta-catenin pathway via targeting miR-191.
circulation_biomarker_diagnosis_up	36815956	hsa-mir-519d	Coronary Artery Disease	METHODS: The expression level of miR-22, miR-30c, miR-145, miR-519d, interleukin 6 (IL-6), and transforming growth factor beta (TGF-) was determined in peripheral blood mononuclear cells (PBMCs) from 46 patients with CAD and 39 healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay.
lncRNA target	36815949	hsa-mir-137	Lupus Erythematosus, Systemic	Furthermore, miR-137 inhibitor intervention induced healthy CD4+ T cell pyroptosis and apoptosis via mediating AMPK, whereas miR-137 mimic transfection into CD4+ T cells of SLE patients leads to opposite results.
genetics_GWAS	36815649	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	LncRNA MCM3AP-AS1 enhances cell invasion, migration and tumor formation in non-small cell lung cancer cells by epigenetic inhibition of miR-34a.
other	36815359	hsa-mir-195	Breast Neoplasms	Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown.
other	36815359	hsa-mir-497	Breast Neoplasms	Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown.
genetics_overexpression_promote	36815253	hsa-mir-665	Adenocarcinoma of Lung	PTPRB overexpression offsets the pro-proliferative potential of miR-665 in LUAD cells.
other	36814857	hsa-mir-124	Periodontitis	The study was designed to examine the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miRNA-124 in the differentiation of osteoclasts, to provide new clues or evidences for the pathogenesis of periodontitis.
other	36814556	hsa-mir-24	Nasopharyngeal Carcinoma	3p/GAD1 axis is converged to modulate the growth, migration, and invasion of NPC cells.
target gene	36814555	hsa-mir-4757	Lung Neoplasms	miR-4757-3p Inhibited the Migration and Invasion of Lung Cancer Cell via Targeting Wnt Signaling Pathway.
other	36814316	hsa-let-7f	Schimke immunoosseous dysplasia	Moreover, we found that SI gammadelta T cells shaped the gut microbiota and regulated intestinal homeostasis by secreting the fecal micro-RNA let-7f.
lncRNA target	36814156	hsa-mir-141	Prostatic Neoplasms	3p suppressed the tumor growth of PCa in vivo.
lncRNA target	36814152	hsa-mir-361	Alzheimer Disease	In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR3p.
lncRNA target	36813149	hsa-mir-199a	Stomach Neoplasms	The conspicuously increased expression of DDR2 was found in GC cell lines, luciferase reporter assays verified that miR-199a-3p directly targeted DDR2 gene, which was correlated to tumor progression. CONCLUSION: Phenotype screens and disseminated verifications incriminating in GC exposit the miR-199a-3p-DDR2-mTOR-SOX2 axis as a clinically actionable target for tumor PM progression.
genetics_knock down_promote	36813147	hsa-mir-146b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: Our results revealed that CAF-derived exosomes contained higher levels of miR-146b-5p than NFs, and miR-146b-5p overexpression in exosomes promoted the malignant phenotype of OSCC by targeting HIPK3.
other	36813098	hsa-mir-1	Li-Fraumeni Syndrome	In addition, we found a positive association between miRNA3p and LF (beta = 0.039, 95% CI = 0.002, 0.080).
transcription factor target	36812841	hsa-mir-124	Pneumonia	3p or activation of the p38MAPK pathway reversed the alleviative effect of CGA on pneumonia in vitro.
lncRNA target	36812568	hsa-mir-4299	Triple Negative Breast Neoplasms	CONCLUSION: In general, the findings suggest that lncRNA AC093850.2 was closely related to the prognosis and progression of TNBC by sponging miR-4299, which might be a prognosis predictor and potential target for treating TNBC patients.
other	36812225	hsa-mir-155	Sepsis	5p, could be useful biomarkers for detecting sepsis.
other	36811957	hsa-mir-181c	Squamous Cell Carcinoma of Head and Neck	Meanwhile, circFNDC3B sequestered miR-181c-5p to upregulate SERPINE1 and PROX1, which drove epithelial-mesenchymal transition (EMT) or partial-EMT (p-EMT) in OSCC cells and promoted lymphangiogenesis to accelerate lymph node metastasis.
other	36811541	hsa-mir-34a	Neuroblastoma	5p expression involved in regulating p53-mediated pathway are also considered.
other	36811541	hsa-mir-137	Neuroblastoma	5p expression involved in regulating p53-mediated pathway are also considered.
other	36811533	hsa-mir-125b-2	Breast Neoplasms	Patients with a luminal BC showing higher levels of miR-125b-2 and miR-320a expression before therapy demonstrated better response to NHT with tamoxifen. CONCLUSIONS: The high levels of miR-125b-2, -155, -221, and -320a in tumor tissue are associated with the HER2/neu-positive status of luminal BC subtypes.
target gene	36811283	hsa-mir-6838	Breast Neoplasms	Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p.
epigenetics	36811277	hsa-mir-92a	Pancreatic Carcinoma	Taken together, our data suggest that targeting DNA methylation and miR-92a-3p-mediated repression of HIP1R could serve as novel therapeutic strategies for PAAD treatment.
lncRNA target	36811210	hsa-mir-625	Carcinoma, Hepatocellular	3p/PDLIM5 axis inhibits the development of HCC.
genetics_knock down_promote	36811106	hsa-mir-106a	Laryngeal Neoplasms	The migration and invasion ability of the LC cells was decreased after the miR-106a-5p knockdown.
circulation_biomarker_diagnosis_down	36810972	hsa-mir-1184	Myocardial Infarction	In AMI serum, circHSPG2 and MAP3K2 mRNA were highly expressed and miR-1184 was down-regulated.
other	36810892	hsa-mir-105	Glioma	5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro.
other	36810892	hsa-mir-9	Glioma	5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro.
exosome	36810326	hsa-mir-204	Glioblastoma	3p tends to be sorted into exosomes.
transcription factor target	36810285	hsa-mir-17	Colorectal Neoplasms	5p contributes to chemotherapy sensitivity in CRC via m(6)A modification is unclear.
lncRNA target	36809926	hsa-mir-101	Transfusion Reaction	Inhibition of miR
lncRNA target	36809926	hsa-mir-101	Hepatitis A	Inhibition of miR
lncRNA target	36809926	hsa-mir-101	Aortic Valve Disease	The finding is important as it reveals that miR-1013p may be a potential therapeutic target for calcific aortic valve disease.
genetics_overexpression_suppress	36809792	hsa-mir-23a	Polycystic Ovary Syndrome	RESULTS: miR-23a-3p was poorly expressed but HMGA2 was overexpressed in GCs of patients with PCOS.
transcription factor target	36809604	hsa-mir-483	Meningioma	CONCLUSION: Meningioma cell growth is critically dependent on autocrine miR-483/IGF-2 stimulation and the IGF-2 pathway provides a feasible meningioma treatment target.
genetics_overexpression_promote	36809521	hsa-mir-194	Osteosarcoma	HK2 overexpression weakened the inhibiting impacts of miR
transcription factor target	36809070	hsa-mir-29b-2	Respiratory Distress Syndrome	In the current study, we provide evidence that AhR activation can attenuate LPS-mediated ARDS through the activation of Th22 cells in the lungs, which are regulated through miR-29b5p.
lncRNA target	36808502	hsa-mir-499	familial febrile seizures 1	It also upregulated SIRT1/PGC-1alpha/Nrf1/TFAM profiles at both gene and protein levels, Mfn2 protein, and microRNA-499 expression, and downregulated Drp1 protein and Beclin1, LC3, and p62 genes (P < .05 to P < .001). Co-application of NMN/melatonin within the setting of I/R injury in the aged rat heart induced noticeable cardioprotection through modulation of a coordinated network including microRNA-499 expression along with mitochondrial biogenesis associated with SIRT1/PGC-1alpha/Nrf1/TFAM profiles, mitochondrial fission/fusion, and autophagy, therefore, appears to prevent the burden of myocardial I/R injury in elderly patients.
transcription factor target	36808485	hsa-mir-3529	Adenocarcinoma of Lung	The underlying mechanism may be that MSA alleviates hypoxia and has synergistic effects in cellular ROS promotion with miR
other	36808381	hsa-mir-34a	Fibrosis	In conclusion, our study indicated that the p53/miR-34a axis promotes the development of renal fibrosis.
genetics_knock down_promote	36808302	hsa-mir-579	gastric adenocarcinoma	Accordingly, cell proliferation, cholesterol synthesis and SQLE expression were significantly inhibited by circ_0000182 knockdown in STAD cells, and these effects were partly reversed by miR
lncRNA target	36808266	hsa-mir-1249	Carcinoma, Non-Small-Cell Lung	In vivo assay showed that circ_0001715 promoted the NSCLC progression through the miR
other	36807979	hsa-mir-122	Hepatitis C	Efficient hepatitis C virus (HCV) RNA accumulation is dependent upon interactions with the human liver-specific microRNA, miR-122.
lncRNA target	36807469	hsa-mir-138	Stomach Neoplasms	5p/PLAGL2 molecular signaling axis in GC, and our findings provide enlightenment for further understanding of the mechanism of tumorigenesis and development of GC, making LGALS8-AS1 a possible new diagnostic or therapeutic target for GC.
circRNA target	36807271	hsa-mir-1205	Breast Neoplasms	The expression of circ_0137652, miR-1205, and CCNB1 in BC tissues and cell lines were detected using RT-qPCR and/or western blotting. Furthermore, miR-1205 inhibits BC progression by targeting CCNB1.
lncRNA target	36806318	hsa-mir-200b	Carcinoma, Non-Small-Cell Lung	Furthermore, LncRNA ATB depletion suppressed NSCLC cells proliferation, migration and invasion, while miR-200b inhibitor or pcDNA-FN1 rescued these effects. CONCLUSION: In summary, our outcomes elucidated that LncRNA ATB/miR-200b axis expedited NSCLC cells proliferation, migration and invasion by up-regulating FN1.
lncRNA target	36806251	hsa-mir-525	Osteoarthritis	5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-kappaB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA.
transcription factor target	36806218	hsa-mir-144	Carcinoma, Hepatocellular	3p/FOXK1 axis repressed malignant progression of HCC via affecting the aerobic glycolytic process of HCC cells.
lncRNA target	36806197	hsa-mir-187	Embryo Loss	In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX.
lncRNA target	36806197	hsa-mir-187	Anovulation	miR-187, a miRNA down-regulated during follicular atresia in sows, maintains TGFBR2 mRNA stability in sow GCs by directly binding to its 5'-UTR. In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX.
other	36806086	hsa-mir-29a	Prostatic Neoplasms	These findings proved that the important role of miR-29a-5p in prostate cancer ferroptosis.
other	36805538	hsa-mir-183	Stomach Neoplasms	p-regulation of microRNA-183 reduces FOXO1 expression in gastric cancer patients with Helicobacter pylori infection.
transcription factor target	36805456	hsa-mir-23b	Arthritis, Rheumatoid	Following the intravenous injection of FP/miR-23b nanoparticles in experimental RA models, the nanoparticles show therapeutic efficacy with inhibition of inflammatory response, reduced bone and cartilage erosion, suppression of synoviocyte infiltration and the recovery of mobility.
other	36804532	hsa-mir-455	Pneumonia, Mycoplasma	Bioinformatics analysis confirmed that decidual stromal cells derived from PE patients expressed significantly lower miR3p than those derived from healthy donors.
target gene	36804476	hsa-mir-10a	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
target gene	36804476	hsa-mir-217	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
target gene	36804476	hsa-mir-512	Colorectal Neoplasms	Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways.
exosome	36804284	hsa-mir-20b	Brain Injuries, Traumatic	Furthermore, high level of microglial exosomal miR-20b-5p induced by mild hypothermia could transfer into injured neurons and promote neurite outgrowth and synapse recovery after TBI via activating the PI3K-AKT pathway by suppressing PTEN expression.
other	36803590	hsa-mir-192	Myelodysplastic Syndromes	CONCLUSIONS: This study shows that high levels of miR5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide.
other	36803590	hsa-mir-192	Leukemia	5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide.
other	36802524	hsa-mir-155	Breast Neoplasms	Furthermore, the biosensor could discriminate breast cancer patients evidently by analyzing exomiR-155, and these results conformed to that of qRT-PCR.
genetics_knock down_suppress	36802224	hsa-mir-1236	Pneumonia	CONCLUSION: Circ_0099188 knockdown might mitigate LPS-induced HPAEpiC cell injury by targeting the miR3p/HMGB3 axis, providing an underlying therapeutic strategy for pneumonia treatment.
lncRNA target	36801666	hsa-mir-4731	Breast Neoplasms	CONCLUSION: Collectively, BCSCs-EVs-mediated delivery of ARRDC1-AS1 may promote the malignant phenotypes of BC cells via the miR
other	36801567	hsa-mir-16	Cardiomegaly	In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy.
other	36801567	hsa-mir-15a	Cardiomegaly	In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy.
lncRNA target	36801509	hsa-mir-539	Colorectal Neoplasms	Mechanistically, we found that TP73-AS1 targeted miR
lncRNA target	36801505	hsa-mir-877	Breast Neoplasms	In summary, TRG-AS1 acts an endogenous RNA, inhibited breast cancer bone metastasis by competitively binding with miR5p to upregulate WISP2 expression.
circulation_biomarker_prognosis_up	36801489	hsa-mir-132	Epilepsy	3p serum levels performed better than each separately as a diagnostic biomarker to distinguish epilepsy patients from controls.
lncRNA target	36801480	hsa-mir-34a	Bone-Associated Metastatic Breast Cancer	MicroRNA-34a (miRNA-34a) is a promising anti-cancer miRNA for gene therapy to bone metastatic cancer patients. The results of experiments in vitro and in vivo confirmed that the constructed bone-targeted miRNA delivery system PCA/miR-34a can enhance the anti-tumor efficacy in bone metastatic cancer, and provide a potential strategy for gene therapy in bone metastatic cancer.
circRNA target	36801359	hsa-mir-344	Anxiety Disorders	5p might be new targets for the treatment of stress-related disorder.
other	36801359	hsa-mir-344	Memory Disorders	And miR5p mimics could simulate the dendritic spine density reduction, depressive- and anxiety-like behaviors and memory impairment induced by CUMS.
circRNA target	36801359	hsa-mir-344	Stress Disorders, Traumatic	These findings represent the first evidence for the involvement of circSYNDIG1 and its coupling mechanism in depression and anxiety, suggesting that circSYNDIG1 and miR5p might be new targets for the treatment of stress-related disorder.
circRNA target	36801359	hsa-mir-344	Neurotic Disorders	5p might be new targets for the treatment of stress-related disorder.
lncRNA target	36800936	hsa-mir-181a	Squamous Cell Carcinoma of Head and Neck	Moreover, upregulated miR-181a-5p significantly inhibited OSCC cell proliferation, colony formation, invasion, and migration; blocked the cell cycle; and promoted apoptosis.
other	36800843	hsa-mir-199a	Diabetic Nephropathies	Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control.
other	36800843	hsa-mir-199a	Lupus Nephritis	Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control.
other	36800843	hsa-mir-155	Lupus Nephritis	Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients.
other	36800843	hsa-mir-155	Diabetic Nephropathies	Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients.
other	36800833	hsa-mir-223	Sepsis	3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia.
other	36800833	hsa-mir-7110	Sepsis	3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia.
other	36800817	hsa-mir-193a	Endometrial Neoplasms	3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients.
other	36800817	hsa-mir-128	Endometrial Neoplasms	3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients.
other	36800601	hsa-mir-5703	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-652	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-3125	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
other	36800601	hsa-mir-513c	Adenocarcinoma of Lung	miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma.
lncRNA target	36800052	hsa-mir-450b	Osteoporosis	IRF-1 promoted the osteogenic differentiation via mediation of lncRNA XIST/miR-450b/FBXW7 axis, and this finding might shed novel insights on exploring new ideas against osteoporosis.
other	36799446	hsa-mir-125b	Liver Cirrhosis	In vitro, SCT 5-27 treatment of a human biliary PSC cell line decreased proliferation and senescence and SR/TGF-beta1/VEGF-A axis but increased the expression of miR-125b and FoxA2.
genetics_overexpression_promote	36799424	hsa-mir-940	Uterine Cervical Neoplasms	RESULTS: Hsa_circ_0000021 and KPNA2 were overexpressed and inversely associated with the levels of miR
genetics_overexpression_promote	36799154	hsa-mir-29a	Glioma	By conducting hypoxia experiments in vitro on U251 glioma cells, it was found that the expression level of miR29a3p decreased following hypoxia, while overexpression of miR29a3p significantly decreased the proliferation of U251 glioma cells and promoted apoptosis by inhibiting the expression of the antiapoptotic marker Bcl2 and increasing the expression of the proapoptotic marker Bax The potential targets of miR29a3p were predicted by online tools and validated by a dualluciferase gene reporter assay.
other	36798914	hsa-mir-29a	Diabetic Nephropathies	RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats.
other	36798914	hsa-mir-377	Diabetic Nephropathies	RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats.
other	36798788	hsa-mir-122	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-95	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-204	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798788	hsa-mir-552	Colorectal Neoplasms	3p) were identified as common DEMs in GSE56350 and GSE73178 datasets.
other	36798467	hsa-mir-200	Brain Neoplasms	However, currently, there is no known therapeutic role for miR-200 family members in the setting of BM.
circulation_biomarker_diagnosis_ns	36798431	hsa-mir-21	Pancreatic Carcinoma	Here, we refined the original method by simultaneously measuring the serum miR5p level to enhance the detection of PDAC.
genetics_knock down_promote	36797846	hsa-mir-1299	Esophageal Squamous Cell Carcinoma	All experimental data showed that knockdown of circPPFIA1 contributed to radiosensitivity in ESCC by inducing miR
genetics_overexpression_promote	36797791	hsa-mir-128	Stomach Neoplasms	Overexpressed TUFT1 reduced miR
other	36797674	hsa-mir-758	Migraine Disorders	5p) novel signature has been found differentially expressed between controls and patients with migraine.
other	36797674	hsa-mir-342	Migraine Disorders	5p) novel signature has been found differentially expressed between controls and patients with migraine.
genetics_knock down_promote	36797317	hsa-mir-1270	Pancreatic Carcinoma	The repressive effects of NR3C1 knockdown on PC cell malignant phenotypes were partly abolished by miR-1270 inhibition.
genetics_overexpression_promote	36796652	hsa-mir-125b	Glioma	Mechanistic studies revealed that circ101491 upregulated EDN1 expression through sponging miR-125b-5p, thus facilitating glioma progression. In summary, hypoxia could promote circ101491 overexpression in glioma cell-derived exosomes, and circ101491/miR-125b-5p/EDN1 regulatory axis might be implicated in the malignant progression of glioma.
lncRNA target	36796622	hsa-mir-1278	Glioma	These findings display that circPKD2 can function as a tumor suppressor in glioma by controlling the miR-1278/LATS2 axis and provide the potential biomarkers for glioma treatment.
lncRNA target	36796497	hsa-mir-214	Nephritis, Interstitial	3p attenuates T-2 toxin-induced chondrocyte apoptosis and ECM degradation through a potential NF-kappaB signaling pathway.
genetics_overexpression_promote	36796259	hsa-mir-149	psoriasis 1	CONCLUSION: The overexpressed miR
other	36795778	hsa-mir-489	Diabetic Retinopathy	CONCLUSION: This study demonstrated that a TPTEP1/miR3p/NRF2 axis affects the development of DR by regulating oxidative stress.
transcription factor target	36795153	hsa-mir-18a	Brain Injuries	Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH.
transcription factor target	36795153	hsa-mir-18a	Subarachnoid Hemorrhage	Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH.
lncRNA target	36794620	hsa-mir-499a	Colorectal Neoplasms	Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing.
lncRNA target	36794620	hsa-mir-6769b	Colorectal Neoplasms	Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing.
other	36794154	hsa-mir-155	Chronic Disease	Conclusion: IL-10 downregulated miR-155 and activated SOCS5, thereby promoting macrophage M2 polarization to relieve chronic rejection after heart transplantation.
other	36793717	hsa-mir-25	Tuberculosis	3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network.
other	36793717	hsa-mir-150	Tuberculosis	3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network.
other	36793496	hsa-mir-34c	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
other	36793496	hsa-mir-20a	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
other	36793496	hsa-mir-338	Colorectal Neoplasms	The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients.
exosome	36793374	hsa-mir-370	Uterine Cervical Neoplasms	The positive feedback loop of exosomal MALAT1/miR-370-3p/STAT3 mediates the cisplatin resistance of cervical cancer cells affecting PI3K/Akt pathway.
other	36793126	hsa-mir-146b	Colorectal Neoplasms	Moreover, we found that miR-146b-3p could be a key regulator for vascular endothelial cell dysfunction.
genetics_overexpression_suppress	36793115	hsa-mir-218	Osteoporosis	5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR
genetics_overexpression_suppress	36793115	hsa-mir-218	Pars Planitis	5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR
lncRNA target	36793108	hsa-mir-130a	Carcinoma, Non-Small-Cell Lung	The in vitro findings were reproduced in vivo, where ITF2357 inhibited the HDAC2/miR-130a-3p/Rad51 axis to reduce the resistance of mut-KRAS NSCLC to Pem. CONCLUSION: Taken together, HDAC inhibitor ITF2357 restores miR-130a-3p expression by inhibiting HDAC2, thereby repressing Rad51 and ultimately diminishing resistance of mut-KRAS NSCLC to Pem.
other	36792543	hsa-let-7a	Breast Neoplasms	Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively.
other	36792543	hsa-mir-21	Breast Neoplasms	Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively.
transcription factor target	36791645	hsa-mir-181a-2	Colorectal Neoplasms	In line with this, the miR-181a3p inhibitor transfection could increase tumorigenicity of NRF2-silenced colorectal cancer cells.
transcription factor target	36791628	hsa-mir-96	Liver Diseases	Data from small RNA sequencing and bioinformatics analysis reveal that miR-396e, one of the most abundant miRNAs of GDE, is the key component to regulate PFKFB3 expression. Mechanistically, miR-396e-mediating PFKFB3 expression plays a crucial role in GDE inhibiting inflammatory response and enhancing lipid metabolism in hepatocytes via the macrophage-hepatocyte crosstalk.
other	36791156	hsa-mir-1262	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-548o	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-205	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-mir-125b-2	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
other	36791156	hsa-let-7b	mesangial proliferative glomerulonephritis	3p was decreased in the MsPGN patient group.
circRNA target	36790665	hsa-mir-497	Prostatic Neoplasms	Our finding revealed that circ_0085494 downregulation might repress PCa tumor progression through in part regulating the miR
lncRNA target	36789845	hsa-mir-483	Myocardial Infarction	3p) to inhibit hypoxia-induced myocardial infarction.
genetics_overexpression_suppress	36789845	hsa-mir-483	Hypoxia	Overexpression of miR
genetics_knock down_suppress	36789690	hsa-mir-96	Cardiomyopathies	5p knockdown using antagomir alleviates the aggravated cardiac fibrosis and exacerbated myocardial function caused by myocardial infarction surgery as shown by the echocardiography and Masson's staining analysis.
lncRNA target	36788697	hsa-mir-370	Inflammation	MiR3p mimics inhibited XIST's effect on inflammation, viability, and apoptosis.
circulation_biomarker_diagnosis_up	36788514	hsa-mir-424	Pre-Eclampsia	METHODS: Blood pressure and 24-h proteinuria of patients with preeclampsia (PE) were measured as well as the levels of miR
genetics_overexpression_promote	36787443	hsa-mir-378a	Ventricular Premature Complexes	TGF-beta1 treatment led to an upregulation of CTGF since early VC but not miR-378a-3p until mid-term VC, while miR-378a-3p overexpression suppressed CTGF expressions without altering TGF-beta1 levels.
circulation_biomarker_diagnosis_ns	36787323	hsa-mir-122	Aortic Aneurysm, Abdominal	CONCLUSION: Plasma exosomes from AAA patients have significantly reduced levels of miRNA5p compared to controls.
genetics_knock down_promote	36787056	hsa-mir-545	Adenocarcinoma of Lung	3p inhibitor partially abolished the inhibition function of lncRNA PCAT6 knockdown on LUAD cells.
exosome	36786721	hsa-mir-183	Chemical and Drug Induced Liver Injury	Moreover, in vivo experiments confirmed that miR-183 and exosomes from ADSCs could improve liver injury in rats and inhibit the MAPK and NF-kappaB pathways. All of these findings demonstrate that exosomes derived from ADSCs have a significant protective effect on hepatic I/R injury by regulating the miR-183/ALOX5 axis, which might provide a therapeutic strategy for liver injury.
other	36786410	hsa-mir-431	Carcinoma, Hepatocellular	CircADSS could regulate HCC cell malignancy by miR5p/TOP2A axis.
lncRNA target	36786348	hsa-mir-450b	Carcinoma, Hepatocellular	Collectively, Silencing HCG18 inhibits GPX4 by binding to miR-450b-5p, promotes GPX4-inhibited ferroptosis, and averts sorafenib resistance in HCC.
genetics_GWAS	36786137	hsa-mir-146a	Gout	METHOD: A case-control study was performed in this report to examine the potential association between gout and the functional rs57095329 SNP of miR-146a in a Chinese population consisting of 448 primary gout patients (containing 76 tophi patients) and 418 healthy controls.
lncRNA target	36785792	hsa-mir-132	Myocardial Infarction	CONCLUSIONS: The current study revealed the critical role of the MBNL1-AS1/miR3p/RAB14/CAMTA1 axis in MI, indicating MBNL1-AS1 as an innovative therapeutic target for MI.
other	36785666	hsa-mir-1321	Pancreatic Carcinoma	Downregulating LINC01503 promoted the availability of miR-1321 in pancreatic cancer cells and thus repressed KLK4 expression.
other	36782343	hsa-mir-433	Osteosarcoma	CONCLUSIONS: Overall, PCGEM1 mediated tumor growth and metastasis of OS by sponging miR3p and regulating OMA1, which might provide an innovative strategy for OS diagnosis or treatment.
lncRNA target	36782115	hsa-mir-130b	Acute Lung Injury	We have previously discovered that microRNA 130b-3p inhibits eCIRP mediated inflammation.
lncRNA target	36781680	hsa-mir-449a	Fibrosis, Renal	Therefore, miR-449a might act as a target in treating RIF.
genetics_overexpression_suppress	36781583	hsa-mir-18a	Osteochondritis Dissecans	ACVR2B served as a direct target of miR-18a-5p, and ACVR2B overexpression might abolish the inhibitory role of miR-18a-5p on OGD/R-treated HBMEC injury.
target gene	36781484	hsa-mir-1298	Polycystic Ovary Syndrome	MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase.
exosome	36781343	hsa-mir-142	Atrial Premature Complexes	These data demonstrate that propofol inhibits osteogenic differentiation and mineralization of MSCs induced by PCa-derived exosomes by regulation of miR
other	36781308	hsa-mir-133a	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781308	hsa-mir-206	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781308	hsa-mir-133b	Osteoarthritis	However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis.
other	36781251	hsa-mir-132	Depression	Herein, we developed a bidirectional-motivated bimodal isothermal strand displacement amplifier (BB-ISDA) for the ultrasensitive fluorescent and colorimetric detection of MDD-related miRNA-132.
transcription factor target	36781060	hsa-mir-149	Brain Ischemia	5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability.
transcription factor target	36781060	hsa-mir-204	Brain Ischemia	5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability.
genetics_GWAS	36780761	hsa-let-7	Ischemic Stroke	Detecting let-7 promoter polymorphisms could raise awareness of the risk of IS, which directed individuals with risk alleles to have regular checks at an appropriate frequency to avoid developing the disease.
lncRNA target	36780323	hsa-mir-143	Myocardial Reperfusion Injury	3p's pathological role in the early stages of MI/RI, and inhibiting miR
other	36780058	hsa-mir-338	Carcinoma, Hepatocellular	Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis.
lncRNA target	36779980	hsa-mir-34a	Ovarian Neoplasms	Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC.
lncRNA target	36779980	hsa-mir-205	Ovarian Neoplasms	Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC.
genetics_knock down_promote	36778920	hsa-mir-1225	Carcinoma, Renal Cell	5p treatment further promoted the inhibitory ability of ARL4C knockdown.
lncRNA target	36777862	hsa-mir-34a	Inflammatory Bowel Diseases	CONCLUSIONS: Resveratrol attenuates IBD by promoting MUC2 synthesis via the ANRIL-miR-34a axis.
circulation_biomarker_diagnosis_down	36777859	hsa-mir-185	Pulmonary Disease, Chronic Obstructive	5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD.
circulation_biomarker_diagnosis_down	36777859	hsa-mir-182	Pulmonary Disease, Chronic Obstructive	5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD.
genetics_overexpression_promote	36777845	hsa-mir-145	Carcinoma, Renal Cell	circ-AFF2 and circ-ASAP1 were highly expressed in RCC patient-derived tumor samples; their overexpression correlated with poor prognosis and low miR-145 levels.
genetics_overexpression_promote	36777826	hsa-mir-26a	Cerebral Hemorrhage	In contrast, overexpression of miR-26a alleviated the neurologic damage and promoted cerebral angiogenesis in ICH rats, but these could be attenuated by TUG1 overexpression.
lncRNA target	36777638	hsa-mir-92a	Parkinson Disease	Moreover, the microRNA-TFs-mRNA network revealed that the microRNA-92a family targets all four immune-related genes in PD pathogenesis.
lncRNA target	36777518	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	PSMG3-AS1 increased OSCC cell proliferation and tumor growth and suppressed the inhibitory role of miR-141 in cell proliferation and tumor growth.
genetics_overexpression_suppress	36777504	hsa-mir-181a	Uveal melanoma	Furthermore, silencing GNAQ or AKT3 mimicked the anti-UM effects of miR-181a-5p, whereas overexpression of GNAQ or AKT3 rescued the anti-UM effects induced by miR-181a-5p.
other	36777002	hsa-mir-183	Thyroid Cancer, Papillary	5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability.
other	36777002	hsa-mir-182	Thyroid Cancer, Papillary	5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability.
lncRNA target	36776858	hsa-mir-222	Colorectal Neoplasms	The in vivo results demonstrated that inhibiting miR
lncRNA target	36776858	hsa-mir-222	Inflammatory Bowel Diseases	The in vivo results demonstrated that inhibiting miR
genetics_GWAS	36776296	hsa-mir-495	Thyroid Cancer, Papillary	RESULTS: Overexpression of miR
lncRNA target	36776216	hsa-mir-6827	Ovarian Neoplasms	5p in OC cells, which may provide a potential target and biomarker for the diagnosis or prognosis of OC.
lncRNA target	36776011	hsa-mir-223	Hepatitis B  Virus-Associated Glomerulonephritis	Objective: To investigate the potential function and related mechanism of microRNA-223 (miRNA-223) in the podocyte pyroptosis of hepatitis B virus (HBV)-associated glomerulonephritis induced by HBV X protein (HBx). Conclusion: HBx may promote podocyte pyroptosis of HBV-GN via downregulating miRNA-223 targeting NLRP3 inflammasome, suggesting that miRNA-223 is expected to be a potential target for the treatment of HBV-GN.
exosome	36775818	hsa-mir-146a	Diabetes Mellitus	Here, the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch (SFP) were demonstrated to promote diabetic wound healing.
circRNA target	36775571	hsa-mir-340	Colorectal Neoplasms	Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment.
genetics_overexpression_suppress	36775560	hsa-mir-150	Colonic Neoplasms	3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133(+)CD44(+) cells using both in vitro and in vivo assays.
lncRNA target	36775555	hsa-mir-135a	Hypoxia-Ischemia, Brain	M2 microglia-derived EVs delivered miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibited the activation of NLRP3 inflammasome, thereby reducing neuronal autophagy and ischemic brain injury. Mechanistically, M2 microglia-derived EVs deliver miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibits the activation of NLRP3 inflammasomes, thereby reducing neuronal autophagy and ischemic brain injury.
exosome	36775554	hsa-mir-21	Rett Syndrome	In the present study, we sought to determine whether that exosomal miR5p from USCs could promote early neural formation in a model of RTT.
other	36775545	hsa-mir-140	Alcoholism	Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease.
other	36775545	hsa-mir-140	Liver Injury	Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease.
lncRNA target	36775540	hsa-mir-143	Carcinoma, Non-Small-Cell Lung	3p inhibitor rescued the inhibitory effect of sh-UCC on the proliferation of NSCLC cells.
lncRNA target	36775537	hsa-mir-150	Sepsis	5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway.
lncRNA target	36775537	hsa-mir-150	Cardiomyopathies	5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway.
lncRNA target	36775498	hsa-mir-26b	Leukemia, Myeloid, Acute	This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth factor (CTGF)/vascular endothelial growth factor (VEGFA) axis via targeting miR-26b to regulate angiogenesis of acute myelogenous leukemia (AML), providing new insights into mechanisms of AML.
exosome	36775496	hsa-mir-199a	Thrombocytopenia	Supplementation of extracellular vesicles (EVs) derived from miR-199a-5p-modified ADSCs markedly repress Th17 differentiation by transferring miR-199a-5p to CD4(+)T cells, thus ameliorating experimental ITP.
transcription factor target	36775482	hsa-mir-130b	Adenocarcinoma of Lung	Hence, targeting miR-130b may serve as a potential therapeutic strategy for lung cancer. Hence, miR-130b is a potential therapeutic target for lung cancer.
target gene	36775481	hsa-mir-184	Idiopathic Pulmonary Fibrosis	miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial-mesenchymal transition of airway epithelial cells.
lncRNA target	36775475	hsa-mir-22	Hypogonadism	This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism.
lncRNA target	36775475	hsa-mir-125a	Hypogonadism	This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism.
lncRNA target	36775469	hsa-mir-214	Atrial Fibrillation	XIST then suppresses NLRP3 inflammasome activation and myocardial pyroptosis by reducing miR
circulation_biomarker_prognosis_ns	36775455	hsa-mir-221	Heart Failure	Furthermore, serum miR
genetics_overexpression_promote	36775453	hsa-mir-96	Carcinoma, Hepatocellular	5p transfection promoted proliferation, migration and invasion of SMMC-7721 and MHCC-97H hepatoma cells; whereas the function of oncogenic microRNA-96 was significantly inhibited in GPM6A-overexpressed hepatoma cells.
genetics_overexpression_promote	36775444	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1.
lncRNA target	36775436	hsa-mir-27a	Lung Injury	Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. In the present study, the authors reveal that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
lncRNA target	36775429	hsa-mir-20a	Leukemia, Myeloid, Acute	In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells.
other	36775425	hsa-mir-513a	Lupus Nephritis	Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.
circRNA target	36775423	hsa-mir-20a	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
circRNA target	36775423	hsa-mir-136	Acute Lung Injury	Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI.
genetics_overexpression_promote	36775421	hsa-mir-148a	Nasopharyngeal Carcinoma	Silencing of SRGN and CREB1, as well as miR-148a-5p overexpression, repressed NPC tumor progression in vitro and in vivo.
exosome	36775383	hsa-mir-1246	Glioma	and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.
exosome	36775383	hsa-mir-10b	Glioma	and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.
genetics_GWAS	36775382	hsa-mir-138	Cartilage Diseases	This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA.
genetics_GWAS	36775382	hsa-mir-138	Osteoarthritis	This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA.
genetics_overexpression_promote	36775374	hsa-mir-34b	Asthma	Notably, EZH2 and BTG2 were significantly overexpressed, while FOXO3 and miR-34b were obviously underexpressed in asthma.
lncRNA target	36775364	hsa-mir-96	Osteoarthritis	5p expression, which results in targeting HIF-2alpha 3'-UTR sequences and inhibiting HIF-2alpha in murine cartilage tissue and chondrocytes.
target gene	36775360	hsa-mir-432	Osteosarcoma	MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB.
circulation_biomarker_diagnosis_up	36775328	hsa-mir-143	Myocardial Infarction	CONCLUSIONS: An increase in plasma miR-143 concentrations in the acute phase may be a biomarker predicting recovery of LV function in the chronic phase in AMI patients.
other	36775115	hsa-mir-663a	Lung Neoplasms	GSE and MTE additively upregulated miR-663a and FHIT in lung cancer cell lines; transfection of antisense-miR-663a significantly abrogated the anti-proliferative effects of GSE/MTE, upregulation of FHIT mRNA and protein. LP and siliphos also additively increased miR-663a and FHIT protein in lung tumor xenografts.
other	36774884	hsa-mir-296	Carcinoma, Non-Small-Cell Lung	Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.
lncRNA target	36773565	hsa-mir-144	Diabetes Mellitus, Type 2	3p dysregulation.
other	36772911	hsa-mir-494	Dmd-Associated Dilated Cardiomyopathy	The results showed that the expression level of miR-494 was higher in the myocardial tissue of DCM rats and the myocardial cells of H9c2 treated with HG.
circulation_biomarker_diagnosis_down	36771341	hsa-mir-122	Alzheimer Disease	A final binary logistic regression analysis showed that alpha-tocopherol serum levels were associated with a higher AD probability and partially mediated by miR-122.
circRNA target	36770940	hsa-mir-1268b	Atherosclerosis	In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis and TMP-PF could regulate the circSCRG1/miR-1268b/NR4A1 axis to inhibit angiogenesis in atherosclerosis in vitro, indicating a novel angiogenesis signalling circSCRG1/miR-1268b/NR4A1 pathway in atherosclerosis and the regulatory effects of TMP-PF, which might provide a new pharmaceutical strategy to combat atherosclerotic plaque instability.
target gene	36769824	hsa-mir-197	Osteosarcoma	miR-197-3p Promotes Osteosarcoma Stemness and Chemoresistance by Inhibiting SPOPL.
circulation_biomarker_diagnosis_up	36769594	hsa-mir-1	Aortic Aneurysm, Abdominal	3p expression (overall and for age &lt; 65 years, aneurysm-related death or cardiac death subgroup) when compared to alive patients; further Cox regression yielded an independent relationship of preoperative low serum miR
other	36769379	hsa-mir-145	Premature Ovarian Aging	Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed.
other	36769379	hsa-mir-143	Premature Ovarian Aging	Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed.
lncRNA target	36769373	hsa-mir-340	Nasopharyngeal Carcinoma	3p/FKBP5 network may be instrumental in regulating NPC radioresistance by enhancing autophagy, which provides potential new therapeutic targets for NPC.
other	36769354	hsa-mir-21	Rhegmatogenous Retinal Detachment, Autosomal Dominant	We found the existence of a positive association between the expression of miR-21 (p = 0.017, r = 0.515) and miR-34 (p = 0.030, r = 0.624) and the duration of symptoms related to retinal detachment.
other	36769354	hsa-mir-146a	Rhegmatogenous Retinal Detachment, Autosomal Dominant	Moreover, the expression of miR-146a tended to decrease in patients who developed PVR.
other	36769177	hsa-mir-155	Breast Neoplasms	We found that the system is capable of specific detection of miR-155, a microRNA implicated in the carcinogenesis of human breast cancer.
circulation_biomarker_diagnosis_up	36769143	hsa-mir-434	Brain Injuries, Traumatic	These included 7 brain-enriched plasma miRNAs (miR
circulation_biomarker_diagnosis_up	36769143	hsa-mir-9a	Brain Injuries, Traumatic	These included 7 brain-enriched plasma miRNAs (miR
lncRNA target	36769104	hsa-mir-212	Hypoxia	Then, we predicted the upstream miRNAs of MCM2 through TargetScan and miRanDa and selected miR
lncRNA target	36769104	hsa-mir-212	Cerebrovascular Disorders	Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease.
lncRNA target	36769104	hsa-mir-212	Opitz GBBB Syndrome, X-Linked	Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease.
other	36768818	hsa-mir-20b	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-1	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-517	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-375	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-218	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
other	36768818	hsa-mir-378a	Testicular Germ Cell Tumor	3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs.
transcription factor target	36768805	hsa-mir-92a	Cardiac Microvascular Inflammation	Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease.
lncRNA target	36768805	hsa-mir-92a	Diabetes Mellitus	We previously characterized the cardiac microvascular inflammatory phenotype in diabetic patients and highlighted micro-RNA 92a (miR-92a) as a driver of endothelial dysfunction. Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease.
lncRNA target	36768775	hsa-mir-21	Endometriosis	The Expression of TGF-1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic The molecular pathogenesis of endometriosis has been associated with pathological alterations of protein expression via disturbances in homeostatic genes, miRNA expression profiles, and signaling pathways that play an essential role in the epithelial-mesenchymal transition (EMT) process. Compared to the endometrium of healthy participants, miR-21 expression levels did not change in the eutopic endometrium of women with endometriosis, but the RQ was higher in their endometrial implants.
other	36768614	hsa-mir-124	Diabetic Retinopathy	In rat DR, miR-124 prevents vasoregression and glial activation, improves neuroretinal function, and modulates microglial activation and inflammatory responses.
other	36768376	hsa-mir-16	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
other	36768376	hsa-mir-135	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
other	36768376	hsa-mir-135a	Depression	Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor.
lncRNA target	36768146	hsa-mir-182	Prostatic Neoplasms	In summary, this is the first study to report that miR-182 over-expression in prostate cancer may contribute to EMT by targeting MITF expression.
circulation_biomarker_diagnosis_ns	36766808	hsa-mir-155	Acquired Immunodeficiency Syndrome	We propose that the activation of peripheral blood mononuclear cells (PBMCs) leads to an increased miR-155 expression and production of miR
lncRNA target	36766731	hsa-mir-193a	Breast Neoplasms	In conclusion, miR193a-3p can potentially modify the tumor microenvironment by altering pro-growth BC secretome and inhibiting LEC growth, and may represent a therapeutic molecule to target breast tumors/cancer.
lncRNA target	36766731	hsa-mir-193a	Bulimia Nervosa	We have recently shown that miR193a-3p, a tumor suppressor miRNA, inhibits MCF-7 BC cell-driven growth of VECs via direct antimitogenic actions and alters MCF-7 secretome.
other	36766397	hsa-mir-411b	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-1193	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-485	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-381	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-3957	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-376b	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36766397	hsa-mir-376c	Hidradenitis Suppurativa	3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups.
other	36765584	hsa-mir-21	Colorectal Neoplasms	Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21.
other	36765487	hsa-mir-125	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL.
other	36765487	hsa-mir-195	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL.
other	36765483	hsa-mir-424	Lymphoma, Large B-Cell, Diffuse	5p enhances the drug resistance of DLBCL cells by regulating the PD-1/PD-L1 signaling pathway.
lncRNA target	36765482	hsa-mir-20a	Lymphoma	OBJECTIVE: To investigate the effects of lncRNA HOTAIR on the proliferation, invasion and migration of lymphoma cells through target gene miR-20a-5p and its molecular mechanism. CONCLUSION: HOTAIR affects the proliferation, invasion and migration of lymphoma cells by targeting miR-20a-5p, and its mechanism may be related to the activation of JAK/STAT3 signaling pathway.
transcription factor target	36765480	hsa-mir-144	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	3p can inhibit the proliferation and promote apoptosis of K562 cells, affect the cell cycle, and block K562 cells in S phase, which indicates that miR
lncRNA target	36765401	hsa-mir-148	Stomach Neoplasms	CONCLUSIONS: This study demonstrates that the miR-148/152 family members may prevent gastric cancer stem cell-like properties by targeting ITGA5, which can serve as an appealing target for gastric cancer treatment.
other	36764873	hsa-mir-1178	Breast Neoplasms	3p and thus upregulating TMED3.
other	36764602	hsa-mir-135a	Spinal Cord Injuries	In summary, the miR-135a-5p/SP1 axis regulates astrocyte proliferation and migration after SCI.
exosome	36764461	hsa-mir-203a	Diabetes Mellitus	CONCLUSIONS: Our results demonstrated that the abundant miR-203a-3p present in EpiSC-EXOs can promote M2 macrophage polarization by downregulating SOCS3 and suggested that diabetic wounds can obtain better healing effects through this mechanism.
transcription factor target	36764280	hsa-mir-155	Rhinitis, Allergic	Therefore, our results suggest that blocking the Notch pathway may alleviate miRmediated inflammation via the regulation of immune homeostasis in AR.
transcription factor target	36764278	hsa-mir-223	Acute Liver Injury	CONCLUSIONS: SPC alleviates acute liver injury through up-regulating the expression of miR3p.
circRNA target	36764273	hsa-mir-483	Osteoporosis	In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP.
circRNA target	36764273	hsa-mir-642b	Osteoporosis	In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP.
transcription factor target	36764271	hsa-mir-34b	Myocardial Reperfusion Injury	MiR-34b-3p and Jagged1 levels were increased and decreased in myocardial I/R injury model, respectively, while Dex reversed this effect. Dex relieved the myocardial I/R injury of rats via inhibiting miR-34b-3p and further activating Notch signaling pathway.
lncRNA target	36764156	hsa-mir-100	Stomach Neoplasms	3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells.
lncRNA target	36764156	hsa-mir-145	Stomach Neoplasms	3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells.
lncRNA target	36763225	hsa-mir-199a	Lupus Erythematosus, Systemic	* miR-199a-3p in CD4+ T cells plays a novel role in the pathogenesis of SLE and serves as a potential target for SLE.
lncRNA target	36763221	hsa-mir-769	Colorectal Neoplasms	CONCLUSION: Circ_0084188 upregulated the expression of KIF20A to promote the tumorigenesis of CRC through miR
lncRNA target	36762306	hsa-mir-493	Stomach Neoplasms	Furthermore, research into the underlying mechanisms of propofol's suppressive effects in GC cell proved that propofol therapy improved the degrees of expression of the potential tumor suppressor miR
lncRNA target	36762036	hsa-mir-505	Glioblastoma	All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505.
lncRNA target	36762032	hsa-mir-491	Pancreatic Carcinoma	Collectively, the findings from our study found a new potential strategy for gemcitabine resistance in PCa by illustrating the mechanistic insights of oncogenic ADSC-derived EVs-loaded NEAT1 via regulating the miR
circulation_biomarker_diagnosis_ns	36761245	hsa-mir-506	Osteoporosis, Postmenopausal	CONCLUSION: Our work suggested that circulating miR
circulation_biomarker_diagnosis_ns	36761245	hsa-mir-340	Osteoporosis, Postmenopausal	CONCLUSION: Our work suggested that circulating miR
other	36761165	hsa-mir-1321	Autism Spectrum Disorder	Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD.
other	36761165	hsa-mir-342	Autism Spectrum Disorder	Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD.
other	36760866	hsa-mir-26a	Carcinoma, Renal Cell	After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC.
other	36760866	hsa-mir-27b	Carcinoma, Renal Cell	After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC.
lncRNA target	36760811	hsa-mir-485	Osteoporosis	DISCUSSION: In conclusion, MALAT1 promoted osteogenic differentiation and inhibited cell apoptosis through the miR5p/WNT7B axis, which suggested that MALAT1 is a potential target to alleviate osteoporosis.
other	36760722	hsa-mir-16	Stomach Neoplasms	5p/HMGA1 axis to regulate the Tax resistance of GC cells.
other	36760720	hsa-mir-16	Stomach Neoplasms	PVT1/miR-16/CCND1 axis regulates gastric cancer progression.
lncRNA target	36760719	hsa-mir-153	Carcinoma, Non-Small-Cell Lung	3p sponge and regulated ITGB1 expression via adsorbing miR
lncRNA target	36760373	hsa-mir-135a	Hepatitis B, Chronic	CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway.
lncRNA target	36760373	hsa-mir-135a	Carcinoma, Hepatocellular	CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway.
genetics_overexpression_promote	36760249	hsa-mir-495	Bronchopulmonary Dysplasia	CONCLUSIONS: The aberrant overexpression of miR-495 may contribute to the development of BPD by targeting NEDD4L-ENaC pathway, implying an imbalance in lung fluid clearance.
other	36760244	hsa-mir-34c	Ovarian Neoplasms	We determined that LINC00665 is the most potential lncRNA upstream of ovarian cancer miRNA (hsa-miR-34c-5p)-P2RY14. Intervention of P2RY14 can affect the prognosis of ovarian cancer by affecting LINC00665-miR-34c-5p-P2RY14 axis.
other	36760243	hsa-mir-7	Carcinoma, Hepatocellular	miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
other	36759837	hsa-mir-375	Non-alcoholic Fatty Liver Disease	Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis.
other	36758875	hsa-mir-204	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-146a	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-1	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-16	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-124	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-206	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-132	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
other	36758875	hsa-mir-26a	Depression	3p, hsa-miR-146a-5p, and hsa-miR-26a-5p).
epigenetics	36758856	hsa-mir-29b	Pulmonary Disease, Chronic Obstructive	Collectively, these findings indicate that the miR-29b level in COPD controls Klotho methylation via DNMT3, which maybe a promising target for the treatment of COPD.
circRNA target	36758707	hsa-mir-139	Liver Cirrhosis	Mechanistically, circASPH directly targeted miR
lncRNA target	36758592	hsa-mir-124	Calcinosis	RESULTS: Compared with the blank group and no-load group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor group were increased (P<0.05). Compared with miR-124 inhibitor group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and the expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor combined with DAPT group were significantly decreased(P<0.05).
transcription factor target	36758470	hsa-mir-206	Abortion, Spontaneous	Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women.
transcription factor target	36758470	hsa-mir-18a	Abortion, Spontaneous	Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women.
circulation_biomarker_diagnosis_ns	36757626	hsa-mir-488	Esophageal Squamous Cell Carcinoma	circ_0024108 participated in the progress of ESCC through the miR-488-3p/USP14 axis. Circ_0024108 was differentially expressed in serum exosomes. Circ_0024108 might be a potential biomarker for the diagnosis of ESCC.
other	36757530	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Also, miRNA-34a was positively correlated with metabolic disorders associated with NAFLD such as hypertension and diabetes.
circulation_biomarker_diagnosis_up	36757530	hsa-mir-192	Non-alcoholic Fatty Liver Disease	Thus, larger cohorts are necessitated to certify the utility of serum MiRNA-34a and MiRNA-192 in monitoring the deterioration of NAFLD.
genetics_overexpression_suppress	36757298	hsa-mir-23b	Uterine Diseases	miR-23b-3p overexpression in infertile endometrial organoid-derived epithelial cells did not improve adhesion.
genetics_overexpression_promote	36756790	hsa-mir-21	Carcinoma, Renal Cell	Moreover, upregulation of PTEN, which is a target of miR-21, was observed in ccRCC cells with overexpression of GABPB1-IT1.
exosome	36756722	hsa-mir-128	Brain Ischemia	3p promotes OPC differentiation into OLs by suppressing BMP signaling, indicating that NSC-derived exosomal miR
genetics_knock down_promote	36756719	hsa-mir-542	Glioma	A battery of function experiments, including the CCK-8 viability test, colony formation assay, scratch migration assay, and Transwell invasion assay, was executed to address the responses of glioma cells to MTE treatment and gain or loss of function of lncMEG3, miR
genetics_knock down_promote	36756106	hsa-mir-19b	Leukemia, Myeloid, Acute	Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.
other	36756106	hsa-mir-17	Leukemia, Myeloid, Acute	We have investigated whether changes in the level of micro-ribonucleic acid (miR)-19b, miR-17, and miR-25, Wilms' tumor (WT1), and CCAAT enhancer-binding protein alpha (CEBPA) genes expression affect disease prognosis and clinical outcome in AML patients.
genetics_knock down_promote	36756106	hsa-mir-25	Leukemia, Myeloid, Acute	Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.
target gene	36755807	hsa-mir-502	Colorectal Neoplasms	FOXO1-Induced miR-502-3p Suppresses Colorectal Cancer Cell Growth through Targeting CDK6.
circulation_biomarker_prognosis_up	36755690	hsa-mir-135b	Carcinoma, Hepatocellular	RESULTS: Upregulation of miR-135b-5p was detected in patients with HCC with high serum AFP levels (AFP > 400 ng/ml).
genetics_GWAS	36755123	hsa-mir-4510	Breast Neoplasms	Two SNPs outside the miR-4510 binding site occurred, and Guanine (G) in both BC and NAT was changed into Thymine (T), as compared to the reference sequence (RefSeq).
lncRNA target	36754869	hsa-mir-20b	Cicatrix, Hypertrophic	Small nucleolar RNA host gene 1 (SNHG1) aced as a ceRNA to upregulate CTNNB1 expression via sponging miR-320b in HSFB.
genetics_knock down_promote	36754085	hsa-mir-1299	Triple Negative Breast Neoplasms	MiR-1299 interacted with the 3' untranslated region (3' UTR) of YY1, and YY1 overexpression partly reversed the effects of miR-1299 overexpression on BC progression.
transcription factor target	36753931	hsa-mir-1296	Placenta Accreta	Additionally, the dual-luciferase assay confirmed AGGF1 as a target gene of miR5p in placental tissues of PAS.
exosome	36753414	hsa-mir-218	Anxiety Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Mental Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Anxiety Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-132	Neurotic Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-218	Mental Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
exosome	36753414	hsa-mir-218	Neurotic Disorders	As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
transcription factor target	36753399	hsa-mir-124	Mitochondrial Diseases	These results showed that under high-glucose and high-lipid conditions, the down-regulation of miR3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD.
transcription factor target	36753399	hsa-mir-124	dystonia 5	3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD.
genetics_GWAS	36752600	hsa-mir-27a	Osteitis Deformans	MIR27a exerts its effects on osteoclast differentiation through modulation of Squstm1/p62 whose mutations have been linked to Paget's disease of bone.
genetics_overexpression_promote	36752341	hsa-mir-1283	Her2-Positive Breast Cancer	The miR-1283 overexpression prevented the proliferation and enhanced apoptosis of HER2+ breast cancer cells, as well as inhibited tumor growth.
lncRNA target	36752339	hsa-mir-124	Depression	We speculated that autophagy was enhanced in the CUMS model of depression and might be mediated by miR-124 targeting Ezh2.
lncRNA target	36752331	hsa-mir-210	Severe Acute Respiratory Syndrome	3p was the single unique lung-specific miRNA, which was found to target the NSP3, NSP4, and NSP13 genes of SARS-CoV-2.
lncRNA target	36752150	hsa-mir-101	Nasopharyngeal Carcinoma	3p was decreased in cisplatin-resistant NPC cells and negatively targeted SOX2.
other	36751856	hsa-mir-4533	Celiac Disease	3p, the longer the diet adherence, the less the expression differed from controls.
other	36751856	hsa-mir-2681	Celiac Disease	3p, the longer the diet adherence, the less the expression differed from controls.
circulation_biomarker_diagnosis_up	36751747	hsa-mir-125a	Endometriosis	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-16	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
other	36751747	hsa-mir-99b	Carcinoma, Endometrioid	In ECO group, downregulated expression of miR-16 and miR-125a (P<0.05) was observed, whereas miR-99b, miR-143 and miR-145 were upregulated (P<0.05). miR-145 showed diagnostic power for ECO, and for endometrioid EC, miR-16, miR-99b, miR-125a and miR-145 showed diagnostic potential.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-145	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_up	36751747	hsa-mir-145	Endometriosis	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
circulation_biomarker_diagnosis_ns	36751747	hsa-mir-125a	Carcinoma, Endometrioid	INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
other	36751048	hsa-mir-646	Hypertension	Our findings illustrated the specific molecular mechanism of miR-3646 regulating hypertension.
exosome	36750776	hsa-mir-874	Kidney Diseases	CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage.
exosome	36750776	hsa-mir-874	Acute Kidney Injury	CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage.
exosome	36750722	hsa-mir-4536	Uterine Cervical Neoplasms	HKF-derived exosomes carried miR5p to CC cells and thereby inhibited PDHB-AS expression.
other	36750632	hsa-mir-1236	Ovarian Neoplasms	CONCLUSIONS: Our results provide evidence for the translational involvement of miR-1236 in the lymphangiogenesis of OC by regulating lymphangiogenesis-related factors and support the clinical importance of miR-1236 as a new diagnostic and prognostic biomarker for OC.
genetics_overexpression_promote	36750528	hsa-mir-155	Spinal Cord Injuries	5p overexpression promoted astrocyte activation and glial scarring in an SCI model.
lncRNA target	36750423	hsa-mir-181a	Diabetes Mellitus	Aim: The aim of this study is to investigate the mechanism and interaction of microRNA-181a (miR-181a), toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappaB) in gastric hypersensitivity in diabetic rats. (4) Intrathecal injection of miR-181a agomir down-regulated the expression of TLR4, reduced the hyper-excitability of gastric-specific neurons, and alleviated gastric hypersensitivity.
transcription factor target	36750173	hsa-mir-874	Breast Neoplasms	Through analysis, we found that miR
tissue_expression_up	36750001	hsa-mir-194	COVID-19	METHODS: In this study, T-box expressed in T cells (T-bet), GATA binding protein 3, The retinoid orphan receptor gamma t (RORgammat), forkhead box P3 (FOXP3), interleukin (IL)-17A, IL-8, and CC ligand 20 (CCL20) mRNA levels and, miR-155 and miR-194 levels were evaluated in 70 patients suffered from severe coronavirus disease 2019 (COVID-19) and 70 healthy subjects using Real-Time qPCR technique. MiR-194 may play crucial roles in regulation of RORgammat and IL-17A expression in healthy people, the phenomenon that is disrupted in the severe SARS-CoV-2 infected patients.
other	36749775	hsa-mir-22	Liver Neoplasms	Overall, our study revealed a novel miR3p/CBL/SPRY2/ERK axis that plays an important role in EMT, cell migration, and invasion of liver cancer cells.
genetics_knock down_promote	36749538	hsa-mir-326	Arthritis, Rheumatoid	Knockdown of lncRNA-EWSAT1 could upregulate miR-326 expression and attenuate its proliferation inhibition and apoptosis induction effect in RA-FLS.
circulation_biomarker_diagnosis_ns	36749234	hsa-mir-375	Esophageal Neoplasms	receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma.
genetics_GWAS	36749159	hsa-mir-451a	Polycythemia	3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis.
genetics_GWAS	36749159	hsa-mir-210	Polycythemia	3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis.
lncRNA target	36749091	hsa-mir-206	gastric adenocarcinoma	These findings provide new clues with prognostic and therapeutic implications in STAD and suggest that HOTAIR/miR-206/SOX9 might be a potential new strategy for therapeutic targeting of gastric cancer.
lncRNA target	36748746	hsa-mir-136	Fibrosis, Renal	CONCLUSION: Through in vitro and in vivo experiments, the present study was able to successfully prove that tacrolimus upregulates NORAD to compete with miR
lncRNA target	36748628	hsa-mir-9	Carcinoma, Hepatocellular	BGH3 axis.
genetics_overexpression_promote	36748323	hsa-mir-200a	Endometrial Neoplasms	RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression.
genetics_overexpression_promote	36748323	hsa-mir-15b	Endometrial Neoplasms	RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression.
other	36747515	hsa-mir-376a	Ovarian Neoplasms	CONCLUSION: This study uncovered a novel mechanism that MEG3 sponged miRNA-376a and YBX1 to regulate the expression of RASA1 and exert an effect on the angiogenesis of ovarian cancer.
lncRNA target	36747258	hsa-mir-657	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LINC00326/miR-657/DKK2 axis signaling blocked tumor-associated functions in NSCLC cells through the targeting Wnt/beta-catenin pathway.
other	36747073	hsa-mir-770	Vasoplegia	5p allowed the ability to distinguish between patients who could and could not develop VS, representing a potential predictive biomarker of VS.
circulation_biomarker_diagnosis_up	36747073	hsa-mir-548c	Vasoplegia	3p, and hsa-miR770-5p) were decreased in blood of VASO compared to NONVASO groups.
other	36746925	hsa-mir-4433b	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-4433b	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-4433b	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-28	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Anxiety Disorders	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Depressive Disorder, Major	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-409	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746925	hsa-mir-432	Attention Deficit Disorder with Hyperactivity	5p in ANX cases at wave 2 only.
other	36746221	hsa-mir-206	Intervertebral Disc Degeneration	The ceRNA network suggested that lnc-TMEM44-AS1-hsa-miRHDAC4 may be one crucial axis in IDD.
exosome	36746199	hsa-mir-21	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
exosome	36746199	hsa-mir-223	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
exosome	36746199	hsa-mir-146a	Diabetes Mellitus	The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR
circulation_biomarker_diagnosis_down	36745296	hsa-mir-185	Abortion, Spontaneous	CONCLUSIONS: The current study, for the first time, successfully constructed the correlation between maternal circulating exosomal miR
genetics_knock down_promote	36745282	hsa-mir-96	Carcinoma, Hepatocellular	5p knockdown on hepatoma cell malignant behaviors.
genetics_GWAS	36745138	hsa-mir-221	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-22	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-146a	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-223	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-145	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-20b	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
genetics_GWAS	36745138	hsa-mir-1	Gout	"Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR"
lncRNA target	36744815	hsa-mir-10a	Uterine Cervical Neoplasms	This miR-10a-5p-mediated post-transcriptional regulation of UBE2I is involved in the tumorigenesis, invasion and migration of human cervical cancer.What are the implications of these findings for clinical practice and/or further research? These findings provide mechanistic insights into how miR-10a-5p regulates cervical cancer hyper-proliferation and metastasis, as well as a new target for clinical treatment.
transcription factor target	36744005	hsa-mir-25	Schizophrenia	3p is very likely to be associated with schizophrenia, revealing potential targets for the treatment and clinical diagnosis of schizophrenia.
lncRNA target	36743910	hsa-mir-124	Alzheimer Disease	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets.
lncRNA target	36743910	hsa-mir-103a	Alzheimer Disease	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets.
lncRNA target	36743910	hsa-mir-124	Diabetes Mellitus, Type 2	Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir
lncRNA target	36743367	hsa-mir-204	Carcinoma, Non-Small-Cell Lung	The influence brought from gene LOC285758 knocking out could be reversed through suppressing miRNA-204, causing up-regulated CDK6 as well as LOC285758 expression in NSCLC tissues.
other	36743290	hsa-mir-376a-1	Autism Spectrum Disorder	Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients.
other	36743290	hsa-mir-376a	Autism Spectrum Disorder	Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients.
circulation_biomarker_diagnosis_down	36742232	hsa-mir-203a	Breast Neoplasms	In this study, the plasma levels of miR-129 and miR-203a were evaluated to investigate their diagnostic potential in breast cancer and its metastasis.
circulation_biomarker_diagnosis_ns	36742227	hsa-mir-21	Vitiligo	CONCLUSION: Peripheral blood of vitiligo patients-derived exosomal miR
genetics_knock down_promote	36742154	hsa-mir-34a	Spinal Cord Injuries	TERC knockdown facilitated the regeneration of neuron tissues yet inhibited inflammation in SCI through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis.
genetics_overexpression_suppress	36742139	hsa-mir-148a	Intervertebral Disc Degeneration	We aimed to investigate the effects of miR-148a-3p overexpression on IDD progression.
target gene	36741904	hsa-mir-150	Rhabdomyosarcoma	Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis.
other	36741376	hsa-mir-27a	Colonic Neoplasms	CONCLUSION: Our results indicated that CD55 is regulated by TFCP2, NF-kappaB, miR-27a-3p, and several immune-related genes, which in turn affects colon cancer.
lncRNA target	36741266	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	Conclusions: Our results suggest that Dvl1 is a potential therapeutic target for NSCLC and that miR-214 plays an inhibitory role in Dvl1-mediated activation of Wnt/beta-catenin signalling in NSCLC cells, which could affect NSCLC progression.
target gene	36741009	hsa-mir-106a	Ovarian Neoplasms	circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway.
target gene	36741009	hsa-mir-519d	Ovarian Neoplasms	circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway.
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-499	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-423	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
circulation_biomarker_diagnosis_ns	36740798	hsa-mir-210	Heart Failure, Chronic	Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR
lncRNA target	36740760	hsa-mir-584	Carcinoma, Hepatocellular	3p inhibitor could reverse the effects of LINC00607 downregulation in HCC through rescue experiments.
transcription factor target	36740725	hsa-mir-223	Obesity	We infer that TBT induced miR-223 expression and increased adipogenesis in MSCs through the PPARgamma pathway and that transgenerationally increased expression of miR-223 plays an important role in the development of obesity caused by TBT exposure.
genetics_overexpression_promote	36740679	hsa-mir-140	Stomach Neoplasms	Overexpression of miR
other	36740569	hsa-mir-146a	Lupus Erythematosus, Systemic	Although we shed some light on the role of miR-146a in SLE, further study is recommended to improve our results.
exosome	36739582	hsa-mir-29b	Myocardial Infarction	To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI.
exosome	36739582	hsa-mir-29b	Cardiomyopathies	To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI.
transcription factor target	36739077	hsa-mir-128	Breast Neoplasms	Therefore, EMPA abrogates breast cancer stemness by inactivating SP1 and PKM2 via enhanced miR
other	36738648	hsa-mir-4732	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-939	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-142	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
other	36738648	hsa-mir-23a	Schizophrenia	3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients.
genetics_knock down_promote	36738516	hsa-mir-1238	Prostatic Neoplasms	Also, overexpression of SEPT2 abolished the suppressive impacts of miR
other	36738390	hsa-mir-10395	Stomach Neoplasms	3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance.
other	36738390	hsa-let-7g	Stomach Neoplasms	3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance.
lncRNA target	36738282	hsa-mir-1256	Esophageal Neoplasms	CircKRT1 acted as a sponge for miR-1256 in EC, and in-miR-1256 abolished the inhibitory effect of circKRT14 suppression on EC cell progression.
genetics_knock down_promote	36738165	hsa-mir-1278	Nasopharyngeal Carcinoma	Circ_0000285 knockdown-mediated anti-tumor effects in NPC cells could be largely reversed by silencing of miR-1278 or overexpression of FNDC3B.
genetics_overexpression_promote	36737832	hsa-mir-455	Squamous Cell Carcinoma of Head and Neck	5p overexpression and PDZK1IP1 inhibition promoted collective OSCC cell migration.
lncRNA target	36737782	hsa-mir-26b	Stomach Neoplasms	CONCLUSION: The newly identified miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop plays an important role in inflammation-related GC progression and may serve as a promising therapeutic target for GC.
lncRNA target	36737651	hsa-mir-92b	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737651	hsa-mir-92a	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737651	hsa-mir-320c	Squamous Cell Carcinoma of Head and Neck	Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort.
lncRNA target	36737507	hsa-let-7c	Carcinoma, Hepatocellular	CONCLUSION: Let-7c-5p has been proved to suppress HCC by down-regulating immune-related CDCA8, which will help understand the pathogenesis of HCC and develop drugs for its treatment.
other	36737428	hsa-mir-1208	Breast Neoplasms	Mechanistically, TMEM105 regulated LDHA expression by sponging miR-1208, which further promoted cell glycolysis and BCLM.
circRNA target	36737402	hsa-mir-874	Esophageal Neoplasms	3p/ENAH axis, which might provide novel therapeutic targets for esophageal cancer intervention.
circulation_biomarker_diagnosis_ns	36736597	hsa-mir-200c	sporatic amyotrophic lateral sclerosis	RESULTS: Our results show a dysregulation of a signaling pathway involving ZEB1-AS1/hsa-miR-200c/beta-Catenin in peripheral blood mononuclear cells and in induced pluripotent stem cells-derived neural stem cells from sALS patients.
lncRNA target	36736544	hsa-mir-206	Anxiety Disorders	CONCLUSIONS: In conclusion, the key findings of the current study demonstrate that gut microbiota aggravated anxiety-like behaviors via the miR
other	36736231	hsa-mir-219	Cognition Disorders	This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro.
other	36736231	hsa-mir-219a	Cognition Disorders	This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro.
genetics_knock down_promote	36735765	hsa-mir-92a	Ovarian Neoplasms	MiR-92a not only promotes the proliferation, colony formation and paclitaxel resistance of SKOV3-Tax cells in OC, but also inhibits apoptosis, and it may be related to the regulation of the PTEN/Akt signaling pathway.
other	36735713	hsa-mir-199a	Heart Failure	The miR-199a NP downregulated levels of HSP, which had a certain protective effect against HF and had a high clinical-adoption and promotion value.
other	36735415	hsa-mir-370	Spinal Cord Injuries	circ_0013613 can promote the recovery of SCI by regulating miR3p/CASP1 to mediate neuronal pyroptosis.
tissue_expression_ns	36735043	hsa-mir-150	Pyruvate Kinase Deficiency of Red Cells	5p silencing also mitigated the impact of circVRK1 deficiency on OGD-evoked injury.
lncRNA target	36734950	hsa-mir-125b	Leukemia	miR-125b-5p inhibited leukemia cell proliferation and boosted apoptosis through decreasing MCL1.
transcription factor target	36734882	hsa-mir-181a	Fractures, Bone	These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures.
lncRNA target	36734882	hsa-mir-181a	Osteoporosis	These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures.
other	36734859	hsa-mir-411	Keloid	5p/JAG1 axis.
other	36734858	hsa-mir-873	Osteosarcoma	5p/ROCK1 axis in OS.
genetics_overexpression_suppress	36734856	hsa-mir-3175	Lung Neoplasms	Overexpressing miR-3175 or silencing SEMA6A could hamper the effects of LINC00312 on lung cancer cells. LINC00312 inhibits lung cancer occurrence and progression via the miR-3175/SEMA6A axis.
genetics_knock down_promote	36734855	hsa-mir-105	Carcinoma, Non-Small-Cell Lung	5p or knockdown of GIMAP6 reversed the inhibition of lncRNA EPB41L4A-AS1 overexpression on NSCLC cell proliferation.
genetics_overexpression_promote	36734854	hsa-mir-873	Uterine Cervical Neoplasms	Moreover, overexpression of LMCD1-AS1 promoted CC cell proliferation and EMT process through the regulation of miR
other	36734696	hsa-mir-760	Carcinoma, Hepatocellular	"The article ""LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma"", by Z.-C."
other	36734535	hsa-let-7b	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-21	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-92a	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-92a	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-19b	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-21	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-let-7b	psoriasis 1	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
other	36734535	hsa-mir-19b	Arthritis, Psoriatic	Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA.
lncRNA target	36734386	hsa-mir-381	Reperfusion Injury, Cerebral Ischemia	CONCLUSIONS: The present research shows that LncRNA HCG11 silencing protects against cerebral ischemia/reperfusion injury through miR3p to regulate p53.
genetics_knock down_suppress	36734233	hsa-mir-210	Ischemic Stroke	TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits.
genetics_knock down_suppress	36734233	hsa-mir-210	Parkinson Disease	TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits.
lncRNA target	36734072	hsa-mir-671	Alzheimer Disease	Whether GABA can inhibit the reduction in CNTN1/2 expression by regulating CEBPalpha/circAPLP2/miR
other	36733403	hsa-mir-204	Diabetes Mellitus, Type 2	The regulation of TXNIP, miR-204, and MafA might play an important role in the mechanism of diabetes remission following bariatric surgery.
circulation_biomarker_diagnosis_up	36733250	hsa-mir-671	Pneumonia	5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstrual blood-derived stem cells on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury.
circulation_biomarker_diagnosis_ns	36733244	hsa-mir-92b	Pancreatitis	Further validation studies revealed that six miRNAs (miR-216a, miR-216b, miR-217, miR92b, miR-375 and miR-148a) were differentially expressed in the serum samples from patients with acute pancreatitis.
genetics_knock down_promote	36733207	hsa-mir-99a	Carcinoma, Hepatocellular	Finally, the experimental results of overexpression and knockdown confirmed that miRNA-99a-5p could inhibit cell proliferation in HCC, which also suggested that it may be an important tumor suppressor in HCC. CONCLUSION: MiRNA-99a-5p was negatively correlated with HCC progression and could act as a novel therapeutic target for HCC.
target gene	36732923	hsa-mir-361	Triple Negative Breast Neoplasms	LncRNA PRKCQ-AS1 regulates paclitaxel resistance in triple-negative breast cancer cells through miR-361-5p/PIK3C3 mediated autophagy.
other	36732514	hsa-mir-6125	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
other	36732514	hsa-mir-8069	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
other	36732514	hsa-mir-4505	Parkinson Disease	Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD.
target gene	36732504	hsa-mir-7	Colorectal Neoplasms	MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer.
lncRNA target	36732450	hsa-mir-125b	Lupus Erythematosus, Systemic	3p, miR-34a, miR-346, and miR-125b) in SLE PBMC cells was analyzed under proinflammatory cytokine IFNgamma treatment, and miR-125b was identified as the target miRNA.
lncRNA target	36732429	hsa-mir-218	Brain Ischemia	5p and up-regulated SMURF2, thus alleviating cerebral ischemic injury.
lncRNA target	36731227	hsa-mir-223	Diabetic Nephropathies	3p associated with IL6T mRNA and attenuated the progression of DKD by suppressing the downstream STAT3 activation, indicative of the implication of miR
genetics_knock down_promote	36730936	hsa-mir-195	Esophageal Squamous Cell Carcinoma	Finally, in vivo experiments were utilized to validate that knockdown of DGCR5 suppressed the Warburg effect via targeting of the miR-195/HK2 axis to increase the radiosensitivity of ESCC.
transcription factor target	36730721	hsa-mir-3	Non-alcoholic Fatty Liver Disease	Obtained results showed that resveratrol and atorvastatin combination therapy can improve nonalcoholic fatty liver disease by targeting genes involved in cholesterol metabolism and miR33.
genetics_knock down_suppress	36730637	hsa-mir-942	Ovarian Neoplasms	Circ-PIP5K1A knockdown reduced the resistance to DDP in OC via regulating miR
genetics_knock down_promote	36730555	hsa-mir-516b	Thyroid Neoplasms	Finally, we demonstrated that the miR-516b-5p inhibitor was capable of reversing ARAP1-AS1-knockdown's repressive effects on TC cell development by means of regulating PDE5A expression.
genetics_knock down_promote	36730544	hsa-mir-223	Carcinoma, Ovarian Epithelial	In addition, LARP4 knockdown increased the proliferation, migration, and invasion of EOC cells inhibited by miR
lncRNA target	36730426	hsa-mir-520d	Colorectal Neoplasms	PROX1-AS1 facilitated CRC progression and immune escape by targeting miR-520d. To sum up, this study affirmed that PROX1-AS1 could absorb miR-520d to upregulate PD-L1 in CRC, thereby promoting tumor progression and immune escape.
exosome	36730375	hsa-mir-1911	Adenocarcinoma of Lung	The present study demonstrated that M2 macrophage-derived exosomal miR
genetics_overexpression_promote	36730287	hsa-mir-498	Carcinoma, Hepatocellular	Moreover, ODC1 was a direct target of miR-498 and ODC1 overexpression abated the anticancer roles of miR-498 in HCC.
transcription factor target	36730262	hsa-mir-29a	Deltaretrovirus Infections	The objective of this study was to determine the relative expression of BLV-encoded miRNA blv-miR-b4-3p, the host analogous miRNA bo-miR-29a and a couple of potential target mRNAs (HBP-1 and PXDN, with anti-tumorigenic function in B-cells), in cattle naturally infected with BLV compared to uninfected animals (control group). Considering the similar expression of endogenous bo-miR-29a in both animal groups, the downregulation of PXDN in BLV-naturally infected cattle could be linked to blv-miR-b4-3p expression in these animals.
circRNA target	36729977	hsa-mir-377	Esophageal Neoplasms	Our study found that circ_0058063 could regulate the expression of HOXA1 by targeting miR
genetics_knock down_suppress	36729852	hsa-mir-508	Ovarian Neoplasms	3p overturned the effects of circSETDB1 knockdown on the Ptx resistance of ovarian cancer cells.
lncRNA target	36729201	hsa-mir-17	Wounds and Injuries	5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds.
lncRNA target	36729201	hsa-mir-17	Wounds, Nonpenetrating	CONCLUSIONS: Collectively, these results reveal a novel molecular mechanism that the autophagy pathway enhanced by Neat1/miR5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds.
other	36729102	hsa-mir-625	Uterine Cervical Neoplasms	Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1.
lncRNA target	36728962	hsa-mir-145	Carcinoma, Endometrioid	CONCLUSION: Circ_0005667 enhanced DDP resistance in EC by elevating IGF2BP1 through sponging miR
circulation_biomarker_prognosis_ns	36728308	hsa-mir-221	Thyroid Neoplasms	CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients.
circulation_biomarker_prognosis_ns	36728308	hsa-mir-146b	Thyroid Neoplasms	CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients.
other	36728308	hsa-mir-146b	Thyroid Diseases	The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification.
other	36728308	hsa-mir-221	Thyroid Diseases	The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification.
transcription factor target	36728287	hsa-mir-200b	Cholangiocarcinoma	CONCLUSION: L-Fucose inhibited the progression of CCA via the miR-200b/MAPK7 and signal transducer and activator of transcription 3 signaling pathways.
circRNA target	36728267	hsa-mir-92a	Pre-Eclampsia	The circRNA_06354/hsa-miR-92a-3p/VEGF-A axis might be a therapeutic target in the prevention and treatment of EOPE.
genetics_GWAS	36727832	hsa-mir-4736	Carcinoma, Pancreatic Ductal	Furthermore, blocking miR-4736 suppresses tumor growth in genetically engineered KPC (LSL-KrasG12D/+, LSL-Trp53R172H/+, and Pdx
circRNA target	36727737	hsa-mir-520h	Carcinoma, Non-Small-Cell Lung	MiR-520h restoration impaired gefitinib resistance and suppressed NSCLC cell proliferation, migration, and invasion by repressing YAP1.
other	36727735	hsa-mir-95	Cholangiocarcinoma	3p/TRAF3 axis and may become a novel approach for treating CHOL.
genetics_knock down_suppress	36727613	hsa-mir-509	Breast Neoplasms	CONCLUSION: Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR
other	36727428	hsa-mir-424	Nasopharyngeal Carcinoma	5p expression.
other	36727260	hsa-mir-29	Glioblastoma	miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42.
other	36727260	hsa-mir-29a	Glioblastoma	miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42.
genetics_overexpression_promote	36727232	hsa-mir-424	Carcinoma, Hepatocellular	5p mimic can reverse the role of overexpression of KIF23 in promoting the ability of HCC cells to proliferate, migrate and invade (P<0.05).
circulation_biomarker_diagnosis_up	36727070	hsa-mir-155	Carcinoma, Renal Cell	5p in serum was significantly upregulated in RCC patients, and miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-126	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-146a	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_ns	36726971	hsa-mir-21	Inflammation	Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR
circulation_biomarker_diagnosis_up	36726727	hsa-mir-1287	Microscopic Polyangiitis	5p in the exosomes obtained from MPA plasma.
other	36726727	hsa-mir-1287	Endothelial Inflammatory Injury	CONCLUSION: Our study revealed that MPA-exo was involved in the intercellular transfer of miR5p and subsequently promote the development of acute endothelial injury in MPA.
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-744	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-155	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-93	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-93	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-495	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-451a	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-155	Frailty	3p serum concentration was reduced, whereas that of miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-495	Sarcopenia	Serum concentration of miR-451a, miR
circulation_biomarker_diagnosis_ns	36726153	hsa-mir-451a	Frailty	CONCLUSION: These results suggest that serum miR-451a should be investigated as a potential biomarker for frailty and show that the VIVIFRAIL multicomponent program modulates circulatory miRNAs expression, at least in older adults.
circRNA target	36726025	hsa-mir-1178	Myocardial Infarction	Together, our results reveal that circCEBPZOS attenuates detrimental post-MI remodeling via the miR3p/PDPK1 axis, which facilitates revascularization, ultimately improving the cardiac function.
other	36724751	hsa-mir-142	Mesothelioma	CONCLUSION: This study proposed that the miR3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.
circulation_biomarker_diagnosis_up	36724195	hsa-mir-26a	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-20a	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-142	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-485	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
circulation_biomarker_diagnosis_up	36724195	hsa-mir-20b	Multiple Sclerosis, Chronic Progressive	In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR
exosome	36723877	hsa-mir-20	Reperfusion Injury, Cerebral Ischemia	hUC-MSCs-Exos-derived circDLGAP4 reduced cerebrovascular injury by regulating miR-320/KLF5 signaling.
transcription factor target	36723677	hsa-mir-181a	Osteoporosis	The CTR, NFATC1, MMP-9, CTSK, and TRAP mRNA expression levels were substantially reduced during osteoclast differentiation and bone resorption in the Res treatment group.The results suggest that Res can reduce the RAW 264.7 cell differentiation into osteoclasts and relieve LPS-stimulated osteoporosis, and the underlying mechanism may be associated with the Res-inhibited activity of the TRAF6/TAK1 pathway through the increased miR-181a-5p expression.
other	36723462	hsa-mir-656	Hypertension	related dysfunction of endothelial cells in hypertension.
other	36723144	hsa-mir-18b	Alzheimer Disease	Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration.
other	36723144	hsa-mir-342	Alzheimer Disease	Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration.
transcription factor target	36723042	hsa-mir-146a	Vasculitis	In addition, we demonstrated that miR-146a encapsulated liposomes reduced vascular inflammation responses in HAECs and SMCs through inhibition of ICAM-1 expression and decreased monocyte adhesion. Thus, based on these results, miR-146a encapsulated liposomes may be promising for reducing vascular inflammation by targeting its multiple associated mediators.
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-208b	Acute Coronary Syndrome	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS.
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-143	Death, Sudden, Cardiac	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-208b	Death, Sudden, Cardiac	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR
circulation_biomarker_diagnosis_ns	36723013	hsa-mir-143	Acute Coronary Syndrome	In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS.
tissue_expression_ns	36722721	hsa-mir-21	Breast Neoplasms	Moreover, MFS-CRISPR assay was evaluated by measuring clinical samples, and the difference of miR-21 expression of breast cancer patients and healthy donors was significant.
exosome	36722453	hsa-mir-374c	Carcinoma, Hepatocellular	MiR-374c-5p transferred by exosomes derived from bone marrow mesenchymal stem cell (BMSC) suppressed migration, invasion and proliferation of HCC cells.
genetics_overexpression_promote	36722424	hsa-mir-20a	Stomach Neoplasms	RUNX1-IT1 and miR-20a precursor were predicted to interact with each other, and overexpression of RUNX1-IT1 in GC cells decreased the expression levels of mature miR-20a.
genetics_knock down_promote	36722261	hsa-mir-183	Death	5p, whereas LINC00960 overexpression increases, but its knockdown decreases, the level of Nrdp1 and apoptosis.
lncRNA target	36722214	hsa-mir-493	Diabetic Nephropathies	In conclusion, TTN-AS1 exacerbated ECM accumulation via the miR3p/FOXP2 axis during DN development.
circulation_biomarker_prognosis_ns	36721512	hsa-mir-155	Chronic Gastritis	CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker.
circulation_biomarker_prognosis_ns	36721512	hsa-mir-155	Inflammation	CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker.
exosome	36720469	hsa-mir-378	Ovarian Neoplasms	Our study revealed a previously unknown regulatory pathway whereby CAFs-derived exosomes delivered circIFNGR2 and inhibited the malignant progression of OVCA by circIFNGR2/miR-378/ST5 axis.
genetics_knock down_suppress	36720318	hsa-mir-579	Hypoxia-Ischemia, Brain	CONCLUSION: This study demonstrated that circ_0007706 knockdown assuaged HIE-induced injury by decreasing TRAF6 expression via targeting miR3p.
other	36720158	hsa-mir-146a	Pediatric Cystic Fibrosis	Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling.
other	36720158	hsa-mir-25	Pediatric Cystic Fibrosis	Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling.
other	36719980	hsa-mir-370	Adenocarcinoma of Lung	High miR-370 expression was associated with poor overall survival (OS) among lung adenocarcinoma patients (p = 0.045).
genetics_knock down_promote	36719867	hsa-mir-148a	Leishmaniasis	Increased miR-148a in splenic leukocytes (SL) of dogs with CanL was observed in previous studies, and in silico analysis, identified possible pathways involved in immune response regulation that are affected by this miR.
transcription factor target	36719839	hsa-mir-186	Brain Injuries, Traumatic	5p, through upregulation IGF-1, attenuates the inflammatory factors, oxidative stress and by inhibiting NLRP3/ASC/caspase-1 signal pathway TBI in-vitro model.
other	36719832	hsa-mir-614	Alzheimer Disease	3p, etc.
other	36719832	hsa-mir-2115	Alzheimer Disease	3p, etc.
other	36719832	hsa-mir-193a	Alzheimer Disease	3p, etc.
genetics_overexpression_suppress	36719626	hsa-mir-543	Carcinoma, Non-Small-Cell Lung	TNRC6A was downregulated and miR-543 was overexpressed in NSCLC cells.
other	36719624	hsa-mir-211	Uterine Cervical Neoplasms	CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.
other	36718820	hsa-mir-326	Glioblastoma	In addition, miR-326 was downregulated in glioblastoma cells, which was verified to sponge circRNA-SMO and interact with CEP85. CircRNA-SMO sponges miR-326 to promote glioblastoma proliferation and migration by upregulating CEP85 expression.
genetics_overexpression_promote	36718644	hsa-mir-27a	Glioma	miR-27a-3p overexpression promotes hypoxia-challenged glioma cell aggressiveness, whereas FTO overexpression partially diminishes the oncogenic effects of miR-27a-3p overexpression.
circulation_biomarker_diagnosis_ns	36718306	hsa-mir-24	Lupus Erythematosus, Systemic	CONCLUSION: Our study provided an insight about the role of miR-24 and its target serum YKL-40 protein in the development of SLE-related inflammation and atherosclerosis.
lncRNA target	36717952	hsa-mir-1303	Osteoporosis	RESULTS: miR-1303 was lowly expressed, while cochlin (COCH) and KCNMA1-AS1 were highly expressed in the osteoporosis subjects. CONCLUSIONS: Our findings suggest that the KCNMA1-AS1/miR-1303/COCH axis is a promising biomarker and therapeutic target for osteoporosis.
other	36717793	hsa-mir-455	Intracranial Aneurysm	METHODS: Expression of the circular RNA circ-ATL1 and microRNA miR-455 was detected in IAs by RT-qPCR.
other	36717790	hsa-mir-125b	Asthma, Allergic	CONCLUSIONS: miR-125b-5p is significantly over-expressed in asthma, and AK089514-miR-125b-5p-TRAF6 axis play critical role in asthma by modulating macrophage polarization.
other	36717592	hsa-mir-149	Coronary Artery Disease	5p was verified in the stable CAD patients when compared to other groups.
other	36717592	hsa-mir-122	Coronary Artery Disease	5p was verified in the stable CAD patients when compared to other groups.
lncRNA target	36717528	hsa-mir-194	Squamous Cell Carcinoma of Head and Neck	5p and enhance its target gene (KLF7), thereby affecting OSCC development.
circulation_biomarker_diagnosis_down	36717388	hsa-mir-568	Heart Diseases	The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays.
circulation_biomarker_diagnosis_down	36717388	hsa-mir-568	Heart Failure	The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays.
lncRNA target	36717039	hsa-mir-133b	Breast Neoplasms	In addition, downregulation of NEAT1 decreased the migration and proliferation of BC cells by inhibiting the expression of CXCL12 by reducing the adsorption of miR-133b. Furthermore, inhibition of miR-133b reversed the interference of NEAT1 and CXCL12 in paclitaxel resistance, migration and proliferation of BC cells.
lncRNA target	36716981	hsa-mir-149	Osteoarthritis	CONCLUSION: Our study provides evidence that up-regulated miR-149 alleviates OA via inhibition of VCAM-1 and PI3K/AKT pathway, which is helpful for OA treatment.
circulation_biomarker_diagnosis_up	36716518	hsa-mir-146a	Rhinitis, Allergic	Serum exosome-derived miR-146a-3p seems to be a novel biomarker for predicting the short and long-term efficacies of SLIT in AR patients.
circRNA target	36715861	hsa-mir-186	Retinoblastoma	Circ_0119412 was found to be upregulated in RB, and could accelerate the progression of RB via the miR
other	36715854	hsa-mir-24	Leukemia, Myeloid, Acute	Taken together, this study emphasized the pro-oncogenic role of CEBPA-AS1 in AML and illustrated its connections with the upstream transcription factor ZFX and the downstream regulative axis miR3p/CTBP2, providing important insights to the cancerogenic process in AML.
epigenetics	36715362	hsa-mir-124-2	Uterine Cervical Neoplasms	OBJECTIVE: This study was undertaken to evaluate the performance of FAM19A4 and hsa-mir2 hypermethylation as a triage tool for women who are at risk of developing cervical cancer or high-grade cervical cancer precursor lesions by taking into consideration the cytology report, histology diagnosis, and human papillomavirus (HPV) status.
genetics_knock down_promote	36714464	hsa-mir-155	Diabetic Nephropathies	5p overexpression restored this.
target gene	36714373	hsa-mir-100	Uterine Cervical Neoplasms	Hypoxia-induced paclitaxel resistance in cervical cancer modulated by miR-100 targeting of USP15.
other	36714048	hsa-mir-146a	Asthma	We aimed to investigate the relationship between Treg, miR3p, and miR-146a-5p in relation to asthma phenotypes in search of novel biomarkers of disease severity.
other	36714048	hsa-mir-210	Asthma	3p is a sensitive biomarker and an independent risk factor for BA severity in Egyptian children.
circulation_biomarker_diagnosis_ns	36713778	hsa-mir-128	Parkinson Disease	Interestingly, a concomitant decreased expression of miR-128 was observed in the cellular models of PD. Thus, our study depicts the intracellular role of miR-128 in neuronal apoptosis and neurodegeneration and its implications as a biomarker being detectable in the circulating exosomes of PD patient blood.
other	36712879	hsa-mir-20	Heart Failure	The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction.
other	36712879	hsa-mir-204	Heart Failure	The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction.
other	36710985	hsa-mir-146a	Colorectal Neoplasms	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-215	Obesity	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-215	Colorectal Neoplasms	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
other	36710985	hsa-mir-146a	Obesity	We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer.
genetics_knock down_suppress	36709726	hsa-mir-128	Prostatic Neoplasms	GLIDR knockdown inhibited the invasion, EMT, and proliferation in PCa cells, and GLIDR was shown to sponge miR
exosome	36709645	hsa-mir-4655	Lung Neoplasms	Overall, our results indicated that exosomal miR5p secreted by lung cancer cells after irradiation promoted the proliferation and M2 polarization of macrophages.
other	36709365	hsa-mir-2008	Sjogren's Syndrome	Moreover, circ432 is validated to serve as the sponge of miR-2008, a differential expressed miRNA in SUS-diseased sea cucumbers, by Argonaute 2-RNA immunoprecipitation (AGO2-RIP) assay, luciferase reporter assay and RNA fluorescence in situ hybridization (FISH) in vitro.
other	36709121	hsa-mir-204	Carcinoma, Endometrioid	5p may play an important role in human endometrial cancer.
transcription factor target	36709037	hsa-mir-9a	Epilepsy	The bioinformatic assessment and disease enrichment analysis revealed that miR-9a-5p targets expressed with high confidence in the hippocampus are the most significantly associated with epilepsy.
other	36708978	hsa-mir-642b	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-760	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-424	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708978	hsa-mir-21	Myocardial Infarction	3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated.
other	36708662	hsa-mir-218	Child Development Disorders, Pervasive	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
other	36708662	hsa-mir-218	Heart Septal Defects, Atrial	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
other	36708662	hsa-mir-218	Mental Disorders	These results suggest an underlying mechanism of miR-218 involvement in neuropsychiatric disorders, and the interactions of layer-specific non-coding RNAs and proteins in regulating cortical development.
other	36708662	hsa-mir-218	Schizophrenia	Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia.
circulation_biomarker_diagnosis_up	36708579	hsa-mir-373	Carcinoma, Hepatocellular	This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation. CONCLUSION: Circulating pre-TACE MiR-373 could assist as a noninvasive predictor marker of response to TACE bridging therapy in early HCC patients awaiting liver transplantation.
circulation_biomarker_diagnosis_up	36708579	hsa-mir-210	Carcinoma, Hepatocellular	This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation.
lncRNA target	36708573	hsa-mir-379	Endometrial Neoplasms	5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR
lncRNA target	36708560	hsa-mir-145	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
lncRNA target	36708560	hsa-mir-200	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
lncRNA target	36708560	hsa-mir-21	Urinary Bladder Neoplasms	This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC.
transcription factor target	36708044	hsa-mir-143	Glioma	In addition, the results indicated that miR3p, which might directly target the 3'UTR of the hexokinase 2 (HK2) gene to regulate its protein expression, was subsequently involved in L1CAM-mediated VM formation by glioma cells.
lncRNA target	36708020	hsa-mir-650	Colorectal Neoplasms	RT-qPCR or western blot assays were performed to verify DICER1-AS1, miR-650, and mitogen-activated protein kinase 1 (MAPK1) expression in CRC cells or tissues. CONCLUSION: Our investigations found that upregulation of DICER1-AS1 activates the MAPK/ERK signaling pathway by sponging miR-650 to promote CRC progression, revealing a possible clinically significant biomarker and therapeutic target.
other	36707813	hsa-mir-372	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
other	36707813	hsa-mir-373	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
other	36707813	hsa-mir-671	sporatic amyotrophic lateral sclerosis	5p might be potential ceRNA regulatory pathways.
lncRNA target	36707017	hsa-mir-384	Brain Ischemia	Based on the above results, we speculated that the molecular mechanism of isoflurane post-conditioning to alleviate ischemic neuronal injury may be related to the regulation of miR5p/ATG5-mediated autophagy.
lncRNA target	36706943	hsa-mir-155	Arthritis, Rheumatoid	Further experiments showed that THY1 Ab downregulated the expression of JUNB by the hsa_circ_0094342/miRNA5P/SPI1 axis, inhibited RA angiogenesis and osteoclast differentiation, and relieved RA progression.
lncRNA target	36705783	hsa-let-7d	Hypertrophic Scar Fibrosis	Consistent with the results in vitro, the miR-let-7d mimics effectively ameliorated hypertrophic scar fibrosis in a rabbit ear hypertrophic scar model. Taken together, our results indicated for the first time that miR-let-7d attenuated hypertrophic scar fibrosis through modulation of iron metabolism by reducing iron uptake through DMT1, which may provide a novel therapeutic strategy for hypertrophic scar.
lncRNA target	36705739	hsa-mir-204	Uveal melanoma	As revealed by functional analysis, miR-204 suppressed UM cell invasion and migration.
exosome	36705422	hsa-mir-205	Chronic Periodontitis	This research is aimed to investigate the function of exosomal miR
other	36705420	hsa-mir-1207	Intervertebral Disc Degeneration	Quantitative real time PCR(qRT-PCR), enzyme-linked immunosorbent assay, and western blotting analyses were performed to evaluate the role of LINC01138, hsa-miR5p, and KIAA0101 during extracellular matrix (ECM) protein degeneration and cellular inflammatory response.
other	36705420	hsa-mir-1207	Osteoarthritis	5p is weakly expressed in OA tissues and cell models.
lncRNA target	36705418	hsa-mir-525	Venous Thrombosis	CONCLUSION: LINC00659 played an important role in DVT by regulating the apoptosis of vascular endothelial cells through regulating miR5p/Bax axis.
circulation_biomarker_diagnosis_ns	36705405	hsa-mir-495	Sepsis	RESULTS: In HUVECs stimulated with BS patient serum, NEAT1 expression was increased, while miR
lncRNA target	36705303	hsa-mir-574	Acute Lung Injury	This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6.
lncRNA target	36705303	hsa-mir-574	Sepsis	This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6.
genetics_overexpression_promote	36704943	hsa-mir-141	Pulmonary Fibrosis	3p and/or adenovirus vectors overexpressing Spred2 one week after BLM treatment.
other	36704851	hsa-mir-151a	Colorectal Neoplasms	Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR151a5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC.
transcription factor target	36704832	hsa-mir-155	Carcinoma, Hepatocellular	MiR-155 accelerates HCC cell proliferation, migration and invasion by targeting SHIP1 expression and inducing macrophage M2 polarization.
lncRNA target	36704357	hsa-mir-200a	Endometrial Neoplasms	The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
lncRNA target	36704357	hsa-mir-429	Endometrial Neoplasms	The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches.
circulation_biomarker_prognosis_up	36704329	hsa-mir-5	Migraine Disorders	The combination of serum levels of exosomal has-miR
circulation_biomarker_prognosis_up	36704329	hsa-mir-145	Migraine Disorders	The combination of serum levels of exosomal has-miR
other	36704329	hsa-mir-378a	Migraine Disorders	Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05).
circulation_biomarker_prognosis_up	36704329	hsa-mir-369	Migraine Disorders	The combination of serum levels of exosomal has-miR
other	36704329	hsa-mir-605	Migraine Disorders	Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05).
other	36703917	hsa-mir-497	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
other	36703917	hsa-mir-449b	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
other	36703917	hsa-mir-6087	Squamous Cell Carcinoma of Head and Neck	Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC.
genetics_overexpression_promote	36703756	hsa-mir-199b	Spinal Cord Injuries	Moreover, miR-199b-5p overexpression polarized M1 macrophage into M2 phenotype and promoted neural regeneration in SCI.
other	36703740	hsa-mir-9	Ovarian Neoplasms	Curcumin enhances the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis.
other	36703641	hsa-mir-567	Carotid Artery Diseases	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-4652	Carotid Artery Diseases	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-4652	Dementia, Vascular	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
other	36703641	hsa-mir-567	Dementia, Vascular	hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD.
genetics_knock down_suppress	36702852	hsa-mir-1275	Stomach Neoplasms	Overexpression and knockdown of miR-1275 in vitro could indirectly modulate the above lipid signalling by targeting FAAH, thereby affecting GC progression. Our study indicates that deregulated FAAH is a key lipid signal and the miR-1275/FAAH/AEA/LPA axis can serve as a diagnostic biomarker for GC or as a target for therapy development.
other	36702759	hsa-mir-501	Diabetes Mellitus, Type 2	Expression analysis of the PDGF-miR-501 signaling pathway could represent a powerful tool to classify patients in clinical trials that aim to improve muscle health and glucose homeostasis in diabetic patients.
other	36702354	hsa-mir-221	Inflammation	Previously, we found miR5p was aberrant and associated with the inflammation of RT induction.
transcription factor target	36701994	hsa-mir-34a	Esophageal Squamous Cell Carcinoma	RESULTS: LJZD significantly interfered with ILinduced activation of the miR-34a/STAT3/IL-6R feedback loop in ESCC by restoring the expression of the tumour suppressor miR-34a, and inhibited the proliferation of EC109 oesophageal cancer cells in a dose-dependant manner.
genetics_overexpression_promote	36701370	hsa-mir-130b	Leiomyosarcoma	Conversely, miR-130b-overexpressing LMS cells exhibited Rho-independent invasion, accompanied by down-regulation of Rho-pathway effectors.
genetics_knock down_suppress	36701095	hsa-mir-375	Breast Neoplasms	Knockdown of miR-375 expression in BC cells reduces cell proliferation, migration, and invasion by inverse correlation expression of HOXA5.
transcription factor target	36700779	hsa-mir-205	Atherosclerosis	CONCLUSION: ICA can alleviate AS and inhibit the proliferation and migration of HAVSMCs induced by ox-LDL, potentially mediated by the upregulation of miR5p.
circulation_biomarker_diagnosis_up	36700764	hsa-mir-193b	Elliptocytosis 2	High-throughput sequencing revealed that miR-193b-3p was markedly up-regulated in plasma exosomes of non-rejection LT patients.
genetics_knock down_promote	36700761	hsa-mir-141	Incontinentia Pigmenti	CONCLUSION: Circ_0044411 knockdown promoted cell viability and proliferation, inhibited inflammatory response and apoptosis by regulating miR3p/CCL16 axis, indicating that circ_0044411 might be a potential therapeutic target for IP.
lncRNA target	36700475	hsa-mir-361	Stomach Neoplasms	MUC13, which is targeted by miR
genetics_knock down_promote	36700300	hsa-mir-125a	Carcinoma, Hepatocellular	Overexpression of miR-125a-5p enhanced the repressive effects of CYTOR knockdown on HCC cells, and knockdown of HAX-1 enhanced the inhibitory effects of miR-125a-5p mimics on HCC cells.
lncRNA target	36700043	hsa-mir-10b	Glioma	The effect is mediated by the secreted miR-10b targets phosphoglycerate kinase 1 (PGK1) and insulin-like growth factor binding protein 2 (IGFBP2) that block cell-cycle progression and induce glioma cell death.
lncRNA target	36700022	hsa-mir-20a	Osteoarthritis	And then we analysed miRNA-320a-targeted OA genes via KEGG, GO enrichment and PPI Network.
lncRNA target	36699616	hsa-mir-361	Carcinoma, Hepatocellular	Mechanistically, BBOX1-AS1 enhanced the stability of PHF8 mRNA by targeting the PHF8 inhibitor miR
genetics_overexpression_promote	36699282	hsa-mir-1294	Esophageal Squamous Cell Carcinoma	PBX3 overexpression could reverse the suppressive roles of miR-1294 mimics on ESCC proliferation and invasion.
other	36698420	hsa-mir-194	Carcinoma, Hepatocellular	3p.
genetics_overexpression_promote	36698227	hsa-mir-128	Colonic Neoplasms	CONCLUSION: LncRNA PCAT1 was overexpressed in CC cells and facilitated CC cell proliferation and invasion via inhibition of miR
transcription factor target	36698180	hsa-mir-132	Diabetes Mellitus, Type 2	We identified Kruppel-like factor 7 (KLF7) as a target of miR
target gene	36697993	hsa-mir-103a	Lung Neoplasms	CYTOR Promotes Proliferation of Lung Cancer Cell by Targeting miR-103a-3p to Upregulate HMGB1.
other	36697494	hsa-mir-21	Infertility, Male	This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21.
other	36697494	hsa-mir-21	Infertility, Female	This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21.
circulation_biomarker_diagnosis_up	36697494	hsa-mir-21	Cataract, Congenital Zonular, with Sutural Opacities	MiR-21 abundance was higher in FF and CCs samples than in serum.
exosome	36697316	hsa-mir-92a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-21	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-200c	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-92b	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-24	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-423a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
exosome	36697316	hsa-mir-222	Adenomyosis	3p and hsa-miR-423a-5p were associated with preeclampsia and miscarriage.
exosome	36697316	hsa-mir-26a	Adenomyosis	3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure.
lncRNA target	36697118	hsa-mir-944	Squamous Cell Carcinoma of Head and Neck	Furthermore, FUT8-AS1 enhanced the expression of transcription factor 4 (TCF4) via sponging miR-944 and recruiting fused in sarcoma (FUS), thus affecting OSCC cell biological behaviors via modulation on Wnt/beta-catenin signaling activity. To conclude, TCF4-mediated FUT8-AS1 could exacerbate OSCC cell malignant behaviors and facilitate tumor growth via modulation on miR-944/FUS/TCF4.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-221	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-4487	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-20	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-1908	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-99a	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
circulation_biomarker_diagnosis_ns	36697090	hsa-mir-494	Early-Stage Malignant Melanoma	Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma.
lncRNA target	36696967	hsa-mir-1228	Carcinoma, Non-Small-Cell Lung	Our findings elucidate the potential molecular mechanisms underlying the ability of SNH to suppress NSCLC growth through activation of pyroptosis via the TCONS-14036/miR5p/PRKCDBP pathway.
circulation_biomarker_diagnosis_up	36696711	hsa-mir-142	Rhinitis, Allergic	CONCLUSION: The expression levels of serum miR
circulation_biomarker_diagnosis_up	36696711	hsa-mir-155	Rhinitis, Allergic	CONCLUSION: The expression levels of serum miR
lncRNA target	36696241	hsa-mir-498	Colorectal Neoplasms	A study of the molecular mechanism suggests that a circ-FADS2/miR-498/S100A16/AKT signaling cascade may be a potential therapeutic target for the treatment of CRC.
genetics_knock down_suppress	36696015	hsa-mir-210	Myocardial Infarction	Knockdown of miR3p in N-EVs significantly impaired its ability to protect the heart after myocardial infarction.
genetics_overexpression_suppress	36695693	hsa-mir-449a	Aortic Valve Insufficiency	Overexpression of miR-449a not only inhibited the M1-polarization of macrophages in vitro but also improved the AR of transplant in vivo.
genetics_knock down_promote	36695641	hsa-mir-122	Triple Negative Breast Neoplasms	The expression of hub genes distinguished TNBC tumors with gain or loss of miR-122 from normal breast tissues.
transcription factor target	36695612	hsa-mir-20a	Iris Diseases	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
transcription factor target	36695612	hsa-mir-20a	Fibrosis	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
transcription factor target	36695612	hsa-mir-20a	Kidney Failure, Chronic	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis.
genetics_knock down_suppress	36695612	hsa-mir-20a	Kidney Diseases	Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. Importantly, delivery of the miR-20a-5p mimic or inhibitor in the donor kidneys attenuated or aggravated renal loss and structural damage in cold storage transplantation injury.
other	36695578	hsa-mir-335	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
other	36695578	hsa-mir-27a	Hepatitis E	AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs.
other	36695578	hsa-mir-221	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
other	36695578	hsa-mir-122	Hepatitis E	AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs.
other	36695578	hsa-mir-194	Hepatitis E	We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients.
exosome	36695327	hsa-mir-615	Diabetic Nephropathies	The combined diagnosis of urinary exosomal miRNA
other	36695179	hsa-mir-629	Azoospermia	5p (p = 0.03 and 0.06, respectively).
lncRNA target	36695093	hsa-mir-197	Carcinoma, Hepatocellular	3p/GNA14 (lncRNA/miRNA/mRNA) ceRNA axis to further explain the mechanism of sex-related prognosis in the development of HCC and to provide new insights into candidate biomarkers for targeted therapies.
circRNA target	36694911	hsa-mir-377	Carcinoma, Non-Small-Cell Lung	Furthermore, miR-377 inhibitor reversed the inhibitory ability of circ_0070659 silencing on malignant biological behavior of NSCLC cells. Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC.
lncRNA target	36694626	hsa-mir-766	Colorectal Neoplasms	Besides that, inhibition of miR-766 reduced CRC cell growth and sensitized cells to radiotherapy, and these effects mediated by miR-766 inhibitor were rescued by the silencing of SMAD4.
genetics_overexpression_promote	36694453	hsa-mir-326	Adenocarcinoma of Lung	Moreover, LINC01270 was found inhibiting miR-326 and thereby overexpressing the abundance of LARP1 to promote LUAD development via PI3K/AKT pathway. All of these findings demonstrate thatLINC01270 is a tumor promotor in LUAD via enhancing LARP1 expressed by sponging miR-326 to facilitate the development of LUAD.
transcription factor target	36694425	hsa-mir-34a	Osteomyelitis	EHP might be a potential adjuvant herbal remedy for the treatment of bone nonunion, and miRNA-34a-5p is a novel target for controlling bone and metabolic diseases.
other	36694220	hsa-mir-206	Thyroid Neoplasms	RESULTS: Compared with the patients with benign thyroid nodules, the expression level of miR-206 in fine-needle aspiration cytology of thyroid cancer patients decreased significantly and the expression level of CCND2 increased significantly. CONCLUSIONS: miR-206 and CCND2 may become new biomarkers for clinical diagnosis of thyroid cancer based on the fine-needle aspiration cytology of thyroid nodules.
lncRNA target	36693615	hsa-mir-448	Heart Failure	mediated upregulation in ischemia, suggesting a new mechanism for the antiarrhythmic effect of miR-448 inhibition.
lncRNA target	36693551	hsa-mir-155	Sepsis	In conclusion, our findings indicate that GAS5 suppresses inflammatory responses by modulating the miR5p/SIRT1/HMGB1 axis in sepsis, providing a novel therapeutic target for inflammation in sepsis.
circRNA target	36691537	hsa-mir-665	Triple Negative Breast Neoplasms	Collectively, the regulatory network circAR-E2E4-miRSTAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC.
other	36691432	hsa-mir-181a	Colorectal Neoplasms	Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6.
genetics_overexpression_suppress	36691322	hsa-mir-1287	Carcinoma, Non-Small-Cell Lung	5p interacted with RBBP4, and RBBP4 overexpression partly reversed the inhibitory effect of miR
other	36691005	hsa-mir-17	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-92a-1	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-18a	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-181a	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
other	36691005	hsa-mir-155	Autistic Disorder	5p, as signature regulators for autism using important genes and mRNA-miRNA network.
transcription factor target	36690096	hsa-mir-221	Neurodevelopmental Disorders	Collectively, our data suggest fluoride impairs mitochondrial translation by dysregulating the miR3p/c-Fos/RMND1 axis to trigger mitochondrial dysfunction, leading to neuronal death and neurodevelopment defects.
other	36689923	hsa-mir-185	Asthma	3p/ZNFX1, may exist in asthma.
other	36689317	hsa-mir-375	Neuropathic Low Back Pain	We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP.
other	36689317	hsa-mir-455	Neuropathic Low Back Pain	We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP.
circRNA target	36689155	hsa-mir-146b	Intervertebral Disc Degeneration	Hsa_circ_0040039 may participate in IDD development by mediating the repair and regeneration of NPs through upregulation MMP2 and PCNA mediated by miR-146b-3p.
circulation_biomarker_diagnosis_up	36689014	hsa-mir-15a	Myocardial Infarction	This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression.
circulation_biomarker_diagnosis_up	36689014	hsa-mir-146a	Myocardial Infarction	This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression.
lncRNA target	36688989	hsa-mir-516b	Kidney Calculi	Patients with kidneys stones showed down-regulated LINC01197 and SIRT3 expression, and up-regulated miR-516b-5p expression. In conclusion, the present study revealed that lncRNA LINC01197 inhibited CaOx-induced kidney stones formation by regulating the miR-516b-5p/SIRT3/FOXO1 signaling pathway.
other	36688191	hsa-mir-155	COVID-19	CONCLUSION: The expression of miR-155 increased in patients with DLBCL and/or COVID-19.
other	36688110	hsa-mir-4647	Colorectal Neoplasms	miR-4647 is predicted in silico to bind to the MUC13 gene and was analyzed by RT-qPCR in 187 tumors and their adjacent non-malignant mucosa of patients with CRC.
lncRNA target	36686977	hsa-mir-582	Nasopharyngeal Carcinoma	In brief, the results of the research clarified circSMARCA5 modulated NPC cells' vital movement via the miR
transcription factor target	36686218	hsa-mir-372	Pre-Eclampsia	3p may act as a factor to cause PE and may also be a potential novel therapeutic target for PE.
circulation_biomarker_diagnosis_up	36685889	hsa-mir-628	Alzheimer Disease	We previously reported that plasma miR3p was up-regulated in AD with severe ACD, but not in severe AD without severe ACD or in our healthy controls.
other	36685889	hsa-mir-130a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-mir-27b	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-mir-151a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Keratoconjunctivitis Sicca	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685889	hsa-mir-146a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-let-7e	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
other	36685889	hsa-let-7a	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . Conclusion: Hsa-let-7a-5p, which was significantly up-regulated in AD-ACD (+) and AD-ACD (-) , could positively regulate the important innate immune-related genes such as TLR3, RIG-I, and MDA5.
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Hypersensitivity	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685889	hsa-let-7d	Alzheimer Disease	Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) .
circulation_biomarker_diagnosis_ns	36685889	hsa-let-7a	Dermatitis	It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma.
other	36685833	hsa-mir-24	pancreatic adenocarcinoma	Correlation analysis suggested that the long non-coding RNA (lncRNA) AL049555.1 and the microRNA (miRNA) hsa-miR5p were involved in the expression of RNF169, composing a potential regulatory axis to control the progression of PAAD.
other	36685826	hsa-mir-214	Ischemic Stroke	"The functional enrichment of 282 DEGs between the two clusters was mainly concentrated in the ""regulation of apoptotic signaling pathway,"" ""cellular response to DNA damage stimulus,"" ""adaptive immune system,"" and ""pyroptosis."" The miRLTF-FOXJ1 axis may be a key regulatory pathway for IS."
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-122	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-192	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_ns	36685382	hsa-mir-100	Acquired Immunodeficiency Syndrome	In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR
circulation_biomarker_diagnosis_down	36684655	hsa-mir-143	Diabetes, Gestational	3p levels are downregulated in the peripheral blood of patients with GDM.
other	36684425	hsa-mir-24	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
other	36684425	hsa-mir-23-2	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
other	36684425	hsa-mir-27a	Osteoarthritis	Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis.
exosome	36684253	hsa-mir-3120	Tuberculosis	Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis.
exosome	36684253	hsa-mir-3120	Adenocarcinoma of Lung	Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis.
other	36684045	hsa-mir-499	Carcinoma, Hepatocellular	CONCLUSION: In summary, this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals.
target gene	36684043	hsa-mir-590	Colorectal Neoplasms	Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis.
circulation_biomarker_diagnosis_ns	36683505	hsa-mir-637	Angelman Syndrome	RESULTS: The expression of circ_0033596 and GRB2 was significantly increased, while miR-637 was decreased in the blood of AS patients and ox-LDL-induced HUVECs compared with controls. CONCLUSION: Circ_0033596 depletion protected against ox-LDL-induced HUVEC injury by miR-637/GRB2 pathway, providing a therapeutic target for AS.
circRNA target	36683504	hsa-mir-1197	Angelman Syndrome	CONCLUSION: Circ_0090231 might protect against ox-LDL-mediated HUVEC injury via the miR-1197/RAB22A axis, which provides a therapeutic strategy for endothelial cell damage of AS.
other	36682830	hsa-mir-138	Osteoporosis	Thus, the miR5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis.
epigenetics	36682704	hsa-mir-188	Leukemia, Myeloid, Acute	5p promoter hydroxymethylation, and miR
circulation_biomarker_diagnosis_up	36682281	hsa-mir-130	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-21	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-146	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-182	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
circulation_biomarker_diagnosis_up	36682281	hsa-mir-1	Gallbladder Neoplasms	The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC.
other	36681676	hsa-mir-150	Cardiomyopathies	miR5p may be a predictor of sepsis severity development but warrants further study.
lncRNA target	36681521	hsa-mir-16	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
lncRNA target	36681521	hsa-mir-335	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
lncRNA target	36681521	hsa-mir-20a	Diabetic Nephropathies	After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN.
other	36681070	hsa-mir-182	Triple Negative Breast Neoplasms	5p miRNAs were upregulated in LA (7.82 times, p &lt; 0.005; 6.12 times, p &lt; 0.005, respectively) and TN breast cancer samples (9.42 times, p &lt; 0.0001; 8.51 times, p &lt; 0.0001) compared to normal tissues.
other	36681070	hsa-mir-96	Triple Negative Breast Neoplasms	5p miRNAs were upregulated in LA (7.82 times, p &lt; 0.005; 6.12 times, p &lt; 0.005, respectively) and TN breast cancer samples (9.42 times, p &lt; 0.0001; 8.51 times, p &lt; 0.0001) compared to normal tissues.
genetics_knock down_promote	36680456	hsa-mir-1206	Lung Neoplasms	Moreover, inhibition of miR-1206 could suppress the malignant phenotypes of lung cancer cells, which was attenuated by KLF2 knockdown.
circulation_biomarker_diagnosis_ns	36680208	hsa-mir-141	Schizophrenia	3p, Wnt5a, and Arp2 might be potential clinical blood-based biomarkers or therapeutic targets for schizophrenia.
transcription factor target	36677874	hsa-mir-185	Nasopharyngeal Carcinoma	5p/STIM1 axis may serve as a potentially effective therapeutic target for the treatment of NPC.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-200a	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-141	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
circulation_biomarker_diagnosis_ns	36677130	hsa-mir-21	Ovarian Neoplasms	In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed.
other	36676955	hsa-mir-181c	Triple Negative Breast Neoplasms	Co-treatment of miR-181c-5p mimic and WA (at varying concentration) down-regulated cell cycle progression markers (CDK4 and Cyclin D1) at mRNA and protein levels.
other	36676927	hsa-mir-16	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
other	36676927	hsa-let-7c	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
other	36676927	hsa-mir-363	Metabolic Diseases	Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a.
transcription factor target	36675268	hsa-mir-5591	Diabetes Mellitus	Moreover, the results confirm that the CMF treatment induced a reduction in the ROS production, an increase in the macrophage M2 anti-inflammatory phenotype through the activation of miRNA 5591, a reduction in inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6, an increase in anti-inflammatory ones, such as IL-10 and IL-12 and an increase in the markers related to improved wound healing such as collagen type I and integrins.
other	36675221	hsa-mir-20a	Leukemia, Lymphocytic, Chronic, B-Cell	In a multivariate analysis, high miR-20a expression remained an independent marker predicting long TTT (time to treatment) for CLL patients.
circulation_biomarker_diagnosis_ns	36675122	hsa-mir-221	Severe Asthma	The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR
circulation_biomarker_prognosis_up	36675028	hsa-mir-130a	Endothelial Dysfunction	Hence, serum miR-130a-5p could identify different stages of ED and independently predict CRTd response, therefore representing a novel prognostic HF biomarker.
other	36674994	hsa-mir-151a	Neurodevelopmental Disorders	This pilot study provides evidence that miR-151a-3p may aid the identification of infants at risk for neurodevelopmental delay.
circulation_biomarker_diagnosis_ns	36674813	hsa-mir-122	Non-alcoholic Fatty Liver Disease	miRNA-122, the most abundant liver-specific miRNA, protects hepatic steatosis and inhibits cholesterol and fatty acid synthesis in NAFLD. Previously, we have shown that compared with its expression in healthy controls, miRNA-122 decreased in the liver tissue but gradually increased in the serum of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, suggesting that miRNA-122 could have been transported to the serum.
lncRNA target	36674797	hsa-mir-200b	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
lncRNA target	36674797	hsa-mir-16	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
lncRNA target	36674797	hsa-let-7	Heart Failure	With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure.
other	36674758	hsa-mir-375	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-145	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-155	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-494	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-27	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
other	36674758	hsa-mir-21	Mouth Neoplasms	Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness.
circulation_biomarker_diagnosis_ns	36674679	hsa-mir-24	Diabetes Mellitus, Type 2	Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR
circulation_biomarker_diagnosis_ns	36674679	hsa-mir-24	Diabetes, Gestational	Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR
other	36674633	hsa-mir-200c	Dyslipidemias	Finally, a phenotypic correlation performed in the CAD group revealed lower hsa-miR-200c-3p expression levels in CAD patients affected by dyslipidemia (+DLP, n = 58) (p &lt; 0.01).
epigenetics	36674633	hsa-mir-200c	Coronary Artery Disease	An integrated analysis of genome-wide DNA methylation and miRNA-seq results indicated a significant downregulation of hsa-miR-200c-3p (FCCAD = 2.97, p  0.05) associated to the hypermethylation of two sites (genomic coordinates: chr12:7073122-7073122 and chr12:7072599-7072599) located intragenic to the miR-200c/141 genomic locus (encoding hsa-miR-200c-3p) (p-value = 0.009) in CAD patients.
tissue_expression_ns	36674605	hsa-mir-146a	Brain Ischemia	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-146a	Parkinson Disease	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-155	Brain Ischemia	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
tissue_expression_ns	36674605	hsa-mir-155	Parkinson Disease	These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD.
transcription factor target	36674578	hsa-mir-143	Hyalinosis, Systemic	Furthermore, miR3p was preferentially expressed in SHFs and Itga6 was identified as one of targets.
other	36674578	hsa-mir-143	Motion Sickness	3p in cashmere growth.
other	36674462	hsa-mir-22	Respiratory Tract Infections	Regression analysis identified environmental (daycare attendance, atmospheric pollution, breastfeeding duration), microbial (Verrucomicrobia, Streptococcus phage), and host factors (miR5p) associated with URI frequency (p < 0.05).
lncRNA target	36672938	hsa-mir-204	Endomyocardial Fibrosis	By constructing regulatory networks, lincRNA-ZFP42-ACTC1, lincRNA-AMY2-STAT1, and/or lincRNA-AMY2/miR-204/STAT1 were sieved, and the results indicate that lncRNA could participate in IMF deposition through direct regulation or ceRNA.
lncRNA target	36672843	hsa-mir-126	Peripheral Arterial Disease	The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role of miRNA-126 and the vascular endothelium growth factor (VEGF) angiogenic pathways on this adaptation. WT promoted angiogenesis in the muscle affected by PAD, and miRNA-126 may have a role in this adaptation by inhibiting PI3KR2, enabling the progression of the VEGF signaling pathway.
circulation_biomarker_diagnosis_up	36672841	hsa-mir-34	Multiple Myeloma	We also observed that TP53 and MYC were negatively correlated with mature miR-34 expressions in the plasma cells of patients with MM.
other	36672804	hsa-mir-652	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-5484	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-4463	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-3945	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672804	hsa-mir-920	Stomach Neoplasms	This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility.
other	36672782	hsa-mir-222	Hepatitis E	To our knowledge, it is the first time that miR3p has been described as a reference miRNA for use in CHEV sample analyses.
lncRNA target	36672150	hsa-mir-3916	primary biliary cholangitis 1	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
lncRNA target	36672150	hsa-mir-3916	Fibrosis	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
lncRNA target	36672150	hsa-mir-3916	Cholestasis	We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis.
circulation_biomarker_diagnosis_ns	36672009	hsa-mir-15b	Autism Spectrum Disorder	Upregulated blood miR-15b-5p *expression may represent a useful diagnostic marker of ASD subjects, and it may regulate TGFBR3 mRNA expression.
other	36671979	hsa-mir-34a	Nervous System Diseases	Zip nucleic acid (ZNA)-based genomagnetic assay was developed herein for the electrochemical detection of microRNA-34a (miR-34a), which is related to neurological disorders and cancer.
other	36671979	hsa-mir-34a	Carcinoma, Hepatocellular	To show the applicability of the ZNA-based genomagnetic assay for miR-34a detection in real samples, a batch of experiments was carried out in this study by using the total RNA samples isolated from the human hepatocellular carcinoma cell line (HUH-7).
lncRNA target	36671913	hsa-mir-625	Colorectal Neoplasms	5p promoted cell proliferation and migration but inhibited apoptosis through phenotypic experiments; thus, we initially identified miR
genetics_GWAS	36671508	hsa-mir-146a	Osteoarthritis	Our genetic and transcriptomic data define a crucial role of miR-146a-5p in OA pathogenesis and implicate modulation of miR-146a-5p in articular chondrocytes as a potential therapeutic strategy to alleviate OA.
other	36671388	hsa-mir-675	Carcinoma, Hepatocellular	Oncofetal H19-derived miR-675 expression could be considered a potential noninvasive diagnostic and prognostic biomarker, outstanding the performance of the expression of tissue lncRNA-H19 for HCC.
epigenetics	36670548	hsa-mir-124	Esophageal Squamous Cell Carcinoma	MATERIALS AND METHODS: Promoter methylation of miR129-2, miR124-3 and ZNF569 was assessed, using quantitative methylation-specific PCR (qMSP), in tissue samples from normal esophagus, treatment-naive and post-ChRT ECa, as well as in liquid biopsies from ECa patients. DISCUSSION: MiR129-2(me) , miR124-3(me) and ZNF569(me) accurately discriminate ECa, either pre- or post-ChRT, from normal tissue, enabling ECa detection.
other	36670490	hsa-mir-145	Pneumonia, Mycoplasma	CONCLUSION: This study provided evidence that the up-regulated hsa_circ_0001326 in PE restrained trophoblast cells proliferation, migration, and invasion by sponging miR5p to elevate TGFB2 expression.
other	36670110	hsa-mir-511	Carcinoma, Hepatocellular	In addition, miR5p was expressed at a low level in HCC tissues, was negatively correlated HLTF, and regulated HLTF expression.
lncRNA target	36669583	hsa-mir-9	Carcinoma, Hepatocellular	Twist1-YY1-p300 phase-separated condensates were disrupted by metformin (Met) and thus reduce miR-9 expression, thereby inhibiting the malignant progression of HCC.
circulation_biomarker_diagnosis_ns	36662897	hsa-mir-221	Peripheral Nerve Injuries	Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
circulation_biomarker_diagnosis_ns	36662897	hsa-mir-221	Neuralgia	Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
circulation_biomarker_diagnosis_ns	36662424	hsa-mir-221	Ischemia	The revascularization of miR-221/222-transfeted ADSCs was further verified in a rat hind limb ischemia model. Furthermore, injection of miR-221/222 transfected ADSCs significantly improved rat hindlimb ischemia, as evidenced by increased blood flow and structural integrity and reduce inflammatory infiltration.
lncRNA target	36661031	hsa-mir-518a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: In vitro lncRNA HOXA11-AS silencing inhibited OSCC stem cell stemness by targeting the miR-518a-3p/PDK1 axis, thus enhancing OSCC cell radiosensitivity.
circulation_biomarker_diagnosis_up	36660723	hsa-mir-21	Lung Injury	3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS.
circulation_biomarker_diagnosis_up	36660723	hsa-mir-21	Shock, Hemorrhagic	3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS.
target gene	36660663	hsa-mir-202	Adenocarcinoma of Lung	MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.
exosome	36660623	hsa-mir-146a	Carcinoma, Non-Small-Cell Lung	Tumor cell-derived exosomal microRNA-146a promotes non-small cell lung cancer cell invasion and proliferation by inhibiting M1 macrophage polarization.
genetics_overexpression_suppress	36660616	hsa-mir-145	Syphilis	Additionally, overexpression of TLR4 reversed the protein expression associated with pyroptosis in M2 macrophage-derived exosome miR
other	36660602	hsa-mir-20a	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
other	36660602	hsa-mir-126	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
other	36660602	hsa-mir-26b	Uterine Cervical Neoplasms	quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells.
exosome	36660450	hsa-mir-210	Epilepsy	Exosomal miR-210 from MSCs attenuated neuronal inflammation and contributed to neurogenesis possibly by inhibiting microglial M1 polarization.
lncRNA target	36660176	hsa-mir-204	Myocardial Reperfusion Injury	5p/FBXW7 axis in myocardial IR injury, and DLX6-AS1 may be a potential target for the treatment of myocardial IR injury.
other	36660044	hsa-mir-10b	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-let-7a	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-mir-21	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
other	36660044	hsa-mir-181a	Pancreatic Carcinoma	The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0.
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-16	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-451a	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-423	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
circulation_biomarker_diagnosis_ns	36659877	hsa-mir-185	Sepsis	Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR
genetics_knock down_promote	36659830	hsa-mir-1277	Endometrial Neoplasms	Besides that, MFGE8 overexpression also attenuated the inhibitory action of miR
lncRNA target	36658478	hsa-mir-1192	Spinal Cord Injuries	CONCLUSIONS: Our study clarified that the lncRNA TUG1/miR-1192/TLR3 axis is an important pathway for PBM to inhibit M1 macrophage polarization and inflammation, which provides theoretical support for its clinical application in patients with SCI.
lncRNA target	36658474	hsa-mir-142	Colitis, Ulcerative	5p was found to be highly expressed in UC, and its silencing inhibited LPS-stimulated Caco-2 cell apoptosis and inflammatory responses.
transcription factor target	36658407	hsa-mir-381	Leukemia, Myeloid, Acute	3p as the tumor suppressor within pediatric AML by targeting ROCK1.
genetics_overexpression_promote	36658310	hsa-mir-195	Adenocarcinoma of Lung	5p overexpression.
circulation_biomarker_diagnosis_ns	36657657	hsa-mir-195	Adenocarcinoma of Lung	5p expression in circulating exosomes of LAC patients was lower than that of healthy controls.
lncRNA target	36657426	hsa-mir-483	Colorectal Neoplasms	Conclusion The results suggested that BCAR4/miR3p/RAB5C axis has the potential to be explored as a novel therapeutic target for CRC treatment.
lncRNA target	36657061	hsa-mir-98	Ovarian Neoplasms	CONCLUSION: SNHG4 accelerates OC development via mediating the miR
other	36656656	hsa-mir-145	Plaque, Atherosclerotic	In vivo, this treatment reduced the atherosclerotic plaque area by 48.04% compared with treatment with free miR-145.
genetics_knock down_suppress	36656536	hsa-mir-93	Urinary Bladder Neoplasms	Knockdown miRNA
lncRNA target	36656498	hsa-mir-450b	Reperfusion Injury	This paper tested the hypothesis that Res could protect against cerebral ischemia-reperfusion injury (CI/RI) by modulating microglial polarization via the miR-450b-5p/KEAP1/Nrf2 pathway. Our study demonstrates that Res exerts neuroprotective effects on microglial M2 polarization through the miR-450b-5p/KEAP1/Nrf2 pathway during CI/RI.
circulation_biomarker_diagnosis_up	36656380	hsa-mir-133a	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circulation_biomarker_diagnosis_up	36656380	hsa-mir-637	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circulation_biomarker_diagnosis_up	36656380	hsa-mir-944	Breast Neoplasms	METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR).
circRNA target	36655489	hsa-mir-124	Fibrosis	Considering the important role of miR-124 in regulating liver fibrosis and HSCs activation, imatinib may exert its anti-fibrotic activity through miR-124.
other	36655275	hsa-mir-181a	Colonic Neoplasms	Collectively, LINC01232 enhances the proliferation, migration, invasion, and angiogenesis of COAD cells by decreasing miR-181a-5p expression.
genetics_overexpression_promote	36654514	hsa-mir-526b	Triple Negative Breast Neoplasms	Overexpression of miR-526b in TNBC cells decreased the expression levels of SLC16A1-AS1, while overexpression of SLC16A1-AS1 did not affect the expression of miR-526b.
lncRNA target	36653891	hsa-mir-28	Diabetes, Gestational	CONCLUSION: Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR
virus_miRNA	36653806	hcmv-mir-UL22A	Aortic Dissection	hcmv-miR-UL22A-5p high levels in the plasma of Aortic dissection patients
virus_miRNA	36653806	hcmv-mir-UL112	Aortic Dissection	hcmv-miR-UL112-5p high levels in the plasma of Aortic dissection patients
lncRNA target	36653745	hsa-mir-155	Retinal Diseases	CONCLUSIONS: Finally, our study identifies the lncRNA uc007nnj.1/miR5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death.
other	36653745	hsa-mir-155	Ischemia	DISCUSSION: Mechanistically, the results demonstrated that lncRNA uc007nnj.1 acts as ceRNA competitively binding miR5p, thereby enhancing the expression levels of Tle4, thus aggravating ischemia-related apoptosis in RGCs.
lncRNA target	36653745	hsa-mir-155	familial febrile seizures 1	5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death.
transcription factor target	36653507	hsa-mir-35	Breast Neoplasms	We studied the role of miR-335 and -145 on PD-L1 suppression in breast cancer. In summary, we found that miR-335 and -145 are novel tumor suppressors inactivated in BC, and these miRs may serve as potential therapeutic targets for breast cancer treatment.
exosome	36652132	hsa-mir-1827	Colorectal Neoplasms	These findings indicate hUC-MSCs-Exos as an inhibitor of M2 macrophage polarization and liver metastasis in CRC through inducing miR
lncRNA target	36651361	hsa-mir-140	Breast Neoplasms	5p suppressed tumor progression of breast carcinoma cells through inhibition of the AKT/STAT3/NF-kappaB pathway.
transcription factor target	36651333	hsa-mir-146a	Diabetes Mellitus	We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis.
transcription factor target	36651333	hsa-mir-146a	Cognition Disorders	We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis.
other	36651169	hsa-mir-188	Pre-Eclampsia	CONCLUSION: Our study demonstrated that circ_0001326 could promote trophoblast cell proliferation, invasion, migration and EMT in PE by miR3p/HTRA1 axis, indicating a novel insight into the pathogenesis of PE.
lncRNA target	36650622	hsa-mir-140	Lipodystrophy, Partial, Acquired	Inhibition of miR3p attenuated LRRC75A-AS1 deficiency-induced up-regulation of COL II, aggrecan and SOX9.
genetics_knock down_promote	36650344	hsa-mir-944	Tongue Neoplasms	We demonstrate that proliferation, migration, and invasion of tongue cancer cells are suppressed by MMP10 knockdown or miR-944 overexpression.
lncRNA target	36650131	hsa-mir-181a	Osteoporosis	Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis.
lncRNA target	36650131	hsa-mir-181c	Osteoporosis	Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-34a	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-206	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-128	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-21	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-136	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
circulation_biomarker_diagnosis_up	36649032	hsa-mir-512	Glioblastoma	5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM.
other	36648863	hsa-mir-26b	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-22	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-16	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-21	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-21	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-126	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-26b	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-133a	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-25	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-17	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-186	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-126	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-92a	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-183	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-22	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-133a	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-92a	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-186	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-183	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-17	hereditary diffuse gastric cancer	5p).
other	36648863	hsa-mir-25	Colorectal Neoplasms	5p).
other	36648863	hsa-mir-16	Colorectal Neoplasms	5p).
circulation_biomarker_diagnosis_ns	36648741	hsa-mir-21	Fibrosis, Renal	CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology.
circulation_biomarker_diagnosis_ns	36648741	hsa-mir-21	Glomerulonephritis, IGA	CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology.
exosome	36648415	hsa-mir-145	Myopia, Degenerative	5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration.
exosome	36648415	hsa-mir-143	Myopia, Degenerative	5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration.
other	36648259	hsa-mir-145	Breast Neoplasms	CONCLUSIONS: ICORG10/11 is the first Irish multicenter, translational research trial evaluating circulatory miRNAs as biomarkers predictive of long-term survival and correlated increased miR-145 expression with enhanced outcomes in early-stage breast cancer.
lncRNA target	36648213	hsa-mir-455	Depression	3p targets PSD-95 and co-regulates NR2B-PSD
lncRNA target	36647717	hsa-mir-194	Epilepsy, Temporal Lobe	Overall, our findings indicated that GA exerts protective effects on TLE young rats against neuronal injury by inhibiting ferroptosis through the miR
lncRNA target	36646789	hsa-mir-139	Pancreatic Carcinoma	Pancreatic cancer cells gain LPAR4 expression in response to stress by downregulating a tumour suppressor, miR5p.
circulation_biomarker_diagnosis_up	36646015	hsa-mir-133a	Myocardial Infarction, Acute	Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples.
circulation_biomarker_diagnosis_up	36646015	hsa-mir-208a	Myocardial Infarction, Acute	Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples.
lncRNA target	36646008	hsa-mir-223	Pneumonia	3p on its target NLRP3 was suppressed by circPWWP2A, which led to lung fibrosis.
transcription factor target	36645633	hsa-mir-193	Atherosclerosis	Thus, miR5p/SRSF10 may serve as a novel treatment target for atherosclerosis.
circRNA target	36645579	hsa-mir-205	Uterine Cervical Neoplasms	Circ_0000078 inhibits the growth of cancer by interfering with the miR5p/EREG network, acting as a tumor suppressor in CC.
other	36645554	hsa-mir-135b	Breast Neoplasms	mediated gene silencing involved in the ceRNA network of TNBC.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-215	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-527	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
circulation_biomarker_diagnosis_down	36644827	hsa-mir-190b	Prostatic Neoplasms	Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue.
exosome	36644823	hsa-mir-29c	Ovarian Neoplasms	Among the miRNAs downregulated in CAF-Exo, miR-29c-3p in OC tissues was associated with metastasis and survival in patients. These results verify the significant contribution of exosomes from omental CAFs to OC peritoneal metastasis, which could be partially due to the relief of MMP2 expression inhibition mediated by low exosomal miR-29c-3p.
lncRNA target	36644819	hsa-mir-625	Nasopharyngeal Neoplasms	Our results suggest that the circLASP1/miR-625 axis is involved the therapeutic effects of MK-2206 on NPC by regulating autophagy, proliferation, and apoptosis through the AKT/mTOR pathway.
other	36644780	hsa-mir-1525	Influenza, Human	SARS-cov2 and influenza A virus regulation have been connected to ZFP36L1 from miRNA 1525 and ETV5 from miRNA 756, respectively.
other	36644193	hsa-mir-195	Carcinoma, Hepatocellular	The homo sapiens-microRNA-195 (hsa-miR-195) may have contributed to the upregulation of CHEK1 in HCC.
genetics_GWAS	36644163	hsa-mir-100	Biliary Atresia	METHODS: We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects.
exosome	36643863	hsa-mir-589	Stomach Neoplasms	CircSTAU2 could be wrapped in exosomes and delivered to recipient cells, and functioned as a sponge for miR-589 to relieve its inhibitory effect on CAPZA1, thus inhibiting GC progression. CONCLUSION: Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC.
other	36643677	hsa-mir-6833	Bronchopulmonary Dysplasia	CONCLUSIONS: This study identified 1 key upregulated lncRNA (i.e., MERGE.57185.1) in preterm neonatal BPD, and revealed the MERGE.57185.1/hsa-miR5p/EIF5A mechanism in preterm neonatal BPD from the lncRNA-miRNA-mRNA network.
exosome	36643646	hsa-let-7b	Lung Neoplasms	CONCLUSIONS: M1-Exos inhibit the proliferation, invasion, and metastasis of lung cancer cells through miRNA-let-7b-5p and GNG5 signaling pathways and inhibit the anti-apoptotic ability of lung cancer cells.
target gene	36643496	hsa-mir-34a	Ischemic Stroke	Gentamycin Rationally Repositioned to Inhibit miR-34a Ameliorates Oxidative Injury to PC12 Cells.
other	36643367	hsa-mir-196b	Stomach Neoplasms	TCGA data showed a high expression of miR-196b-3p in gastric cancer cases (P < .001).
circRNA target	36643258	hsa-mir-487a	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: Circ_0005050 acted as an oncogenic factor in OSCC progression through miR-487a-3p/CHSY1 axis.
genetics_knock down_suppress	36643221	hsa-mir-2278	Squamous Cell Carcinoma of Head and Neck	GNAS knockdown restored miR-2278 inhibitor-mediated effect in OSCC cells.
exosome	36642417	hsa-mir-9	Osteoarthritis	Intra-articular injection of exosomal miR
other	36642194	hsa-mir-132	Ovarian Neoplasms	These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway.
other	36642194	hsa-mir-195	Ovarian Neoplasms	These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway.
exosome	36642112	hsa-mir-211	Melanoma	We show that the highly metastatic melanoma tumor cells (POL) can transfer their metastatic competency to the low-metastatic melanoma tumor cells (OL) by exosomal miR5p.
transcription factor target	36641890	hsa-mir-155	Cognition Disorders	In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone.
transcription factor target	36641890	hsa-mir-34a	Cognition Disorders	In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone.
genetics_overexpression_promote	36641136	hsa-mir-196b	Glomerulonephritis, IGA	Inhibition of PTEN rescued the therapeutic effects of overexpression of FGD5-AS1 or inhibition of miR-196b-5p on IgAN.
circulation_biomarker_diagnosis_ns	36640912	hsa-mir-128	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Our results show that circulating miRs are potential biomarkers of ALL MRD, asmiR3p level both in PFP and EEF predicts day 15 FC MRD.
exosome	36640325	hsa-mir-27b	Atherosclerosis	Thus, obesity-induced exosomal miR-27b-3p promotes endothelial inflammation and facilitates atherogenesis by PPARalpha suppression.
circulation_biomarker_diagnosis_ns	36640195	hsa-mir-223	Acute Kidney Injury	3p and SNRK expression and high HDAC2 expression in peripheral blood.
other	36640056	hsa-mir-4717	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36640056	hsa-mir-138	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36640056	hsa-mir-28	Arthritis, Rheumatoid	The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group.
other	36639978	hsa-mir-590	Dermatitis, Atopic	Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis.
genetics_knock down_suppress	36639866	hsa-mir-181a	Colorectal Neoplasms	Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway.
other	36639835	hsa-mir-22	Tongue Neoplasms	We also detected activation of miR-22/lncRNA/KAT6B/NF-kappaB signalling in recurrent cancers compared to paired primary tongue cancers.
genetics_GWAS	36639674	hsa-mir-92a-1	Diabetic Nephropathies	5p epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN.
lncRNA target	36639265	hsa-mir-195	Breast Neoplasms	Breast cancer cell proliferation was regulated by the SNHG16/miR-195/PCMT1 axis. CONCLUSION: PCMT1 silencing inhibited cell proliferation and invasion and induced apoptosis in breast cancer cells and the SNHG16/miR-195/PCMT1 regulatory axis might serve as a potential therapeutic target for breast cancer.
other	36639145	hsa-mir-122	Liver Injury	We describe miR-122 concentrations in participants with antituberculosis drug-induced liver injury (AT-DILI). CONCLUSIONS: miR-122 concentrations in our participants with AT-DILI were considerably higher than previously reported in healthy volunteers and in patients on antituberculosis therapy without liver injury.
exosome	36638658	hsa-mir-99b	Neuralgia	Collectively, our findings demonstrated that MSC-EVs had an analgesic effect on neuropathic pain via promoting autophagy, and these antinociceptive effects were at least in part caused by MSC-EV-mediated transfer of miR-99b-3p, thereby inhibiting microglial activation and pro-inflammatory cytokines expression.
other	36637626	hsa-mir-17	Glioblastoma	5p, and Caspase 3 as apoptosis predictors in the GM patients.
other	36637626	hsa-mir-20	Glioblastoma	5p, and Caspase 3 as apoptosis predictors in the GM patients.
circRNA target	36637163	hsa-mir-135a	Carcinoma, Non-Small-Cell Lung	Taken together, circ-N4BP2L2 enhanced NSCLC progression via the miR-135a-5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC.
circulation_biomarker_diagnosis_up	36636641	hsa-mir-10527	Esophageal Squamous Cell Carcinoma	5p was found to be notably reduced in both the plasma exosomes and tumor tissues of ESCC patients with LNM, and plasma exosomal miR
exosome	36636640	hsa-mir-133a	Reperfusion Injury, Cerebral Ischemia	Furthermore, exosomal miR-133a-3p derived from BMSCs markedly alleviated the symptom of CI/R injury in vivo. CONCLUSION: Exosomal miR-133a-3p derived from BMSCs alleviates CI/R injury via targeting DAPK2/Akt signaling.
circulation_biomarker_prognosis_ns	36636634	hsa-mir-342	Lupus Erythematosus, Systemic	Meanwhile, the low expression level of serum miR
genetics_overexpression_promote	36636455	hsa-mir-653	Adenocarcinoma of Lung	5p to AGR2 and stepwise upregulated AGR2 overexpression in LUAD gefitinib resistant cells, resulting gefitinib resistance in LUAD.
lncRNA target	36636079	hsa-mir-6788	Stomach Neoplasms	GC therapy may be improved by conducting targeted studies of the CNALPTC1/miR
transcription factor target	36636078	hsa-mir-17	Colorectal Neoplasms	5p promoted CRC cell proliferation, metastasis, and invasion, while inhibiting apoptosis.
other	36636074	hsa-mir-125b-1	Colorectal Neoplasms	The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
other	36636074	hsa-mir-125a	Colorectal Neoplasms	The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
lncRNA target	36636064	hsa-mir-204	Stomach Neoplasms	NORAD also regulated KMT2D expression by targeting miR5p and mediated PTEN/PI3K/AKT signaling in GC.
lncRNA target	36636050	hsa-mir-767	Stomach Neoplasms	3p-CHD4 axis, which is associated with GC proliferation and carcinogenesis, and may represent a promising therapeutic target for the future cure of GC.
genetics_knock down_promote	36636045	hsa-mir-543	Pancreatic Carcinoma	MicroRNA-543 knockdown dramatically increased PC cell growth, invasion, metastasis, and EMT, as well as decreased apoptosis in functional studies.
other	36636042	hsa-mir-62	Colorectal Neoplasms	circ_0000799 promotes proliferation and invasion in CRC and EMT. These effects of circ_0000799 may be achieved by negatively regulating miR-62.
exosome	36635928	hsa-mir-125a	Nasopharyngeal Carcinoma	RESULTS: miR-125a-5p was highly expressed in NPC tissues and cells. CONCLUSIONS: GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis.
lncRNA target	36635757	hsa-mir-139	Glioblastoma	CONCLUSIONS: According to our research, circNDC80 is an oncogenic factor that promotes glioblastoma through the miR5p/ECE1 pathway.
circRNA target	36635458	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: CircZNF236 modulates OSCC via the miR
lncRNA target	36635290	hsa-mir-142	Carcinoma, Hepatocellular	3p by ST8SIA6-AS1 accelerated the growth of cells while preventing cell apoptosis in LIHC cells, and the inhibitory effect of miR
genetics_knock down_promote	36635223	hsa-mir-625	Carcinoma, Squamous Cell, Cutaneous	Circ_0001402 knockdown can suppress the development and chemoresistance of DDP-resistant CSCC cells at least partly through targeting miR
genetics_overexpression_suppress	36634743	hsa-mir-654	Craniosynostosis radial aplasia syndrome	The inhibition of NEAT1 overexpression on apoptosis and autophagy in OGCs was reversed by miR-654 mimics.
circRNA target	36633774	hsa-mir-339	Colorectal Neoplasms	3p inhibitor partly attenuated this effect.
target gene	36633773	hsa-mir-1304	Lung Neoplasms	Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p.
genetics_overexpression_suppress	36633140	hsa-mir-212	Metabolic Associated Fatty Liver  Disease 	Conversely, the overexpression of miR2123p abolished the ameliorative effects of exercise on MAFLD.
other	36632887	hsa-mir-21	Glioblastoma	INTRODUCTION: miRNA-21 (miR-21) is highly expressed in glioblastoma, facilitating tumor growth by blocking the expression of apoptosis-related genes. Therefore, an antisense microRNA oligonucleotide (AMO) against miR-21 was suggested as a therapeutic nucleic acid for glioblastoma.
other	36632615	hsa-mir-5088	Breast Neoplasms	Our previous study confirmed that miR5p was associated with malignancy and metastasis in breast cancer.
transcription factor target	36632614	hsa-mir-1290	Liver Cirrhosis	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1290	Liver Neoplasms	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Liver Neoplasms	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Liver Cirrhosis	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1290	Carcinoma, Hepatocellular	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
transcription factor target	36632614	hsa-mir-1825	Carcinoma, Hepatocellular	Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC.
lncRNA target	36632453	hsa-mir-1303	Osteosarcoma	APLN increased PLOD2 expression in human osteosarcoma cell lines and cell migration via the mammalian Sterile 20-like kinase 1 (MST1), monopolar spindle-one-binder protein (MOB)1, and YAP cascades, and through hsa_circ_0000004 functioning as a sponge of miR-1303.
genetics_overexpression_promote	36631876	hsa-mir-193b	Pancreatic Carcinoma	miR-193b-3p and TRIM62 were overexpressed or silenced to examine their function in PC.
other	36631465	hsa-mir-33a	Melanoma	Last, a long non-coding (lncRNA) NEAT1/miR-33a-5p/IRS2 regulatory axis of the competing endogenous RNA network was built to investigate the mechanisms of SKCM metastasis progression. These findings highlight the regulatory axis of the lncRNA NEAT1/miR-33a-5p/IRS2, which may play a role in SKCM metastasis.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-200c	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-21	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-34a	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-22	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
circulation_biomarker_diagnosis_ns	36631039	hsa-mir-143	Takayasu Arteritis	5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes.
genetics_GWAS	36631028	hsa-mir-449b	Abortion, Spontaneous	CONCLUSION: There is a significant association between the risk of RPL and miR-449b/TNF-alpha combination, and therefore, genetic analysis for specific combined genotypes can be an important screening method for RPL in Korean women.
other	36631017	hsa-mir-141	Nasopharyngeal Carcinoma	3p and vimentin in NPC tissues increased significantly.
exosome	36631008	hsa-mir-380	Pulmonary Disease, Chronic Obstructive	The expression of miR-380 was significantly elevated in exosomes derived from COPD alveolar macrophages. This process may be involved with abnormal expression of miR-380 in exosomes of COPD alveolar macrophages and down-regulation of CFTR in bronchial epithelial cells.
other	36630972	hsa-mir-99a	Familial Hypophosphatemic Rickets	MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients.
other	36630972	hsa-mir-99a	Norrie disease	The expression of miR-99a-5p was detected in patients with NDR, NPDR, and PDR. MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients.
lncRNA target	36630972	hsa-mir-99a	Duane Retraction Syndrome	In conclusion, MiR-99a-5p protected hRMECs against HG damage, and the miR-99a-5p might be a novel target for diagnosis of DR.
other	36629882	hsa-mir-7	Respiratory Distress Syndrome	5p in ARDS biopsies.
lncRNA target	36629518	hsa-mir-6742	Adenocarcinoma of Lung	RESULTS: Bioinformatics analysis and dual-luciferase identified FGF8 is the target-gene of miR
other	36629013	hsa-mir-136	Stomach Neoplasms	Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway.
genetics_overexpression_promote	36628810	hsa-mir-578	Breast Neoplasms	Additionally, miR-578 inhibitor or GINS4 overexpression could reverse the inhibitory effect of hsa_circ_0008673 silencing on BC cell progression. CONCLUSION: Hsa_circ_0008673 might promote BC progression via modulating miR-578/GINS4 pathway.
genetics_knock down_promote	36628645	hsa-mir-454	Stomach Neoplasms	Long Chain Non-Coding RNA (lncRNA) HOTAIR Knockdown Increases miR3p to Suppress Gastric Cancer Growth by Targeting STAT3/Cyclin D1.
lncRNA target	36628448	hsa-mir-16	Colonic Neoplasms	5p inhibition partly rescued the effects of CERS6-AS1 depletion on CC development.
target gene	36628219	hsa-mir-497	Carcinoma, Hepatocellular	Sanguinarine promotes apoptosis of hepatocellular carcinoma cells via regulating the miR-497-5p/CDK4 axis.
genetics_overexpression_promote	36628205	hsa-mir-29a	Carcinoma, Endometrioid	Overexpression of miR-29a-3p inhibited EC cell growth, migration, and invasion through the regulation of HDAC4, as it is a target of miR-29a-3p.
lncRNA target	36627684	hsa-mir-644a	Breast Neoplasms	Mechanistically, BCAR4 facilitates breast cancer migration and invasion via the miR-644a-CCR7 axis of the MAPK pathway. BCAR4 promotes ABCB1 expression indirectly by binding to and down-regulating miR-644a to induce chemo-resistance in breast cancer.
lncRNA target	36627670	hsa-mir-1275	Adenocarcinoma of Lung	It was transcriptionally repressed by DDP-activated PI3K/AKT/c-Myc signal in LUAD, promoting DDP-acquired chemotherapeutic resistance by regulating miR-1275 to suppress PROCA1/ZFP36L2-induced BCL2 degradation, which led to apoptotic signal reduction.
genetics_overexpression_promote	36627652	hsa-mir-335	Ovarian Neoplasms	RESULTS: Overexpression of FOXD3 impaired the proliferation and chemoresistance of OC cells, which was related to the promotion of the miR-335 expression.
exosome	36627634	hsa-mir-218	Colorectal Neoplasms	5p expression in cells and exosomes, inhibiting PTPRR expression, and ultimately activating the Ras/ERK/c-Fos signaling pathway.
genetics_overexpression_promote	36627571	hsa-mir-106a	Atherosclerosis	CONCLUSION: Overexpression of GASL1 might suppress ox-LDL-induced HUVEC cell viability, apoptosis, and inflammation by regulating miR-106a/LKB1 axis.
lncRNA target	36627545	hsa-mir-1296	Carcinoma, Hepatocellular	In conclusion, hsa_circ_0000519 promoted tumor progression and angiogenesis in HCC through the miR-1296/E2F7 axis.
other	36627081	hsa-mir-10a	Periapical Periodontitis	In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis.
other	36627081	hsa-mir-891a	Periapical Periodontitis	In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis.
genetics_knock down_promote	36627006	hsa-mir-143	Urinary Bladder Neoplasms	3p inhibition or MSI2 overexpression restored the malignant behaviors of BCa cells induced by circ_644 knockdown or RUNX3 overexpression.
transcription factor target	36626918	hsa-mir-32	Prostatic Neoplasms	CONCLUSION: These results indicate that the suppression of miR-32 might offer an auxiliary treatment procedure for addressing the invasion, progression, and metastasis in PCa patients by improving cell apoptosis.
other	36626488	hsa-mir-506	Osteosarcoma	Furthermore, immunohistochemistry and quantitative real-time PCR outcomes indicated that the expression level of SLC7A8 and hsa-miR-506 was differentially expressed in lung metastasis OS tissues and non-metastasis tissues.
lncRNA target	36626439	hsa-mir-137	Postoperative Cognitive Complications	Taking together, this experiment provide the first experimental and clinical evidence that LncRNA GAS5/miR-137 promoted anesthesia-induced cognitive function to increase inflammatory bodies in patients undergoing lumbar spinal canal decompression, suggesting it may be a biomarker of POCD and a potential therapeutic target for POCD.
genetics_GWAS	36626225	hsa-mir-3	Pulmonary Fibrosis	We demonstrate that specific genetic ablation of miR-33 in macrophages protects against bleomycin-induced pulmonary fibrosis.
circRNA target	36626032	hsa-mir-135a	Nasopharyngeal Carcinoma	Together, our study uncovered the tumor-initiating and pro-metastatic role of circMAN1A2-miR-135a-3p-UBR5-ATMIN axis in NPC regulation that may be a potential therapeutic target for human NPC.
circRNA target	36625877	hsa-mir-766	Intestinal Diseases	3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis.
genetics_knock down_suppress	36625260	hsa-mir-498	Colorectal Neoplasms	Since hsa_circ_0079480 knockdown inhibited CRC cells malignant behaviors through regulation of the miR-498/ATP5E axis, it can be concluded that hsa_circ_0079480 might have great potential as therapeutic target for CRC.
lncRNA target	36624948	hsa-mir-222	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624948	hsa-mir-221	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624948	hsa-mir-21	Carcinoma, Renal Cell	PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment.
lncRNA target	36624643	hsa-mir-19b	Irritable Bowel Syndrome	CONCLUSION: We report five novel microRNA-mRNA regulatory axes in IBS-D pathogenesis and speculated that PIK3R3, negatively regulated by hsa-miR-19b-3p, may regulate NF-kappaB production through the PI3K/Akt pathway, which accounts for the occurrence of clinical symptoms in IBS-D patients.
exosome	36624516	hsa-mir-141	Ovarian Neoplasms	CONCLUSIONS: This study uncovers miR-141 as an OvCa-derived exosomal microRNA mediating the tumor-stroma interactions and the formation of tumor-promoting stromal niche through activating YAP1/GROalpha/CXCRs signaling cascade, providing new insight into therapy for OvCa patients with peritoneal metastases.
genetics_overexpression_promote	36624091	hsa-mir-488	Stomach Neoplasms	Overexpression of circPOFUT1 enhanced autophagy-associated chemoresistance of GC cells in vivo, but it was inhibited by overexpression of miR
lncRNA target	36623778	hsa-mir-155	Irritable Bowel Syndrome	CONCLUSIONS: Decreased colonic COMT in PI-IBS-D patients drives abdominal pain phenotypes via the COMT/miR-155/TNF-alpha axis.
circulation_biomarker_prognosis_up	36623770	hsa-mir-98	Carcinoma, Hepatocellular	5p was significantly decreased, while HBEGF expression was significantly increased in the serum of HCC patients compared with the control group.
other	36623676	hsa-mir-125b	Aortic Aneurysm, Abdominal	In conclusion, AAA patients might be benefit from EVAR based on various pathways and some molecules, such as miR-125b and SATB1-AS1, related with shear stress.
exosome	36623674	hsa-mir-125a	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Exosomal miR-125a-3p is a potential predictor of response to anti-PD-1/PD-L1 therapy in advanced NSCLC patients with low PD-L1 expression.
genetics_overexpression_promote	36622742	hsa-mir-181a	Polycystic Ovary Syndrome	CDKN2B-AS1 is overexpressed in PCOS and may sponge miR-181a to promote granulosa cell proliferation.
transcription factor target	36622663	hsa-mir-361	Breast Neoplasms	Together, these studies identify miR3p inhibitor as a potential new treatment for drug-responsive and -resistant advanced BC.
other	36622069	hsa-mir-542	Mesenteric Ischemia	Exogenous S1P analogs administered in vivo protect murine intestinal barrier from damage due to mesenteric ischemia reperfusion, and damaged intestinal tissue had increased levels of miR5p.
target gene	36621840	hsa-mir-140	Breast Neoplasms	Doxorubicin resistance in breast cancer xenografts and cell lines can be counterweighted by microRNA-140-3p, through PD-L1 suppression.
lncRNA target	36621784	hsa-mir-155	Arthritis, Rheumatoid	Objective To investigate the expression regulation of autophagy-related genes(ATG)and the mechanism of autophagy in rheumatoid arthritis(RA).Methods The differentially expressed genes(DEG)of RA were identified from GSE55235 and GSE55457,on the basis of which the differentially expressed autophagy-related genes(DE-ATG)were selected from the Human Autophagy Database.STRING 11.0 and GeneMANIA were used to establish protein-protein interaction networks.Further,the transcription factor-gene-miRNA co-expression network was established via NetworkAnalyst and Cytoscape.Finally,receiver operating characteristic(ROC)curve and DrugBank were employed to evaluate the efficacy of the predicted biomarkers and the performance of drugs targeting DE-ATG.GraphPad Prism 8.2.1 and R 4.0.3 were used for statistical analysis and graphics.Results A total of 485 DEG were enriched in signaling pathways such as T cell activation,hormone regulation,osteoclast differentiation,RA,and chemokines.Eleven DE-ATG regulated the expression of RUNX1,TP53,SOX2,and hsa-mir5p in synovial tissues of RA patients and were involved in the response to environmental factors such as 2,3,7,8-tetrachlorodibenzodioxin and silicon dioxide.The ROC curve analysis identified the DE-ATG with good sensitivity and specificity,such as MYC,MAPK8,CDKN1A,and TNFSF10,which can be used to distinguish certain phenotypes and serve as novel biomarkers for RA.Conclusions In RA,down-regulated DE-ATG expression may promote apoptosis and lysis of chondrocytes.The identified novel biomarkers provides new ideas and methods for diagnosing and treating RA.The establishment of transcription factor-miRNA-gene co-expression network provides direct evidence for dissecting synovial inflammation and articular cartilage destruction.
target gene	36620931	hsa-mir-433	Colorectal Neoplasms	LncRNA IGFL2-AS1 as a ceRNA Promotes HCT116 Cell Malignant Proliferation via the miR-433-3p/PAK4 Axis.
other	36620850	hsa-mir-128a	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-149	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-145	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
other	36620850	hsa-mir-181b	Glioblastoma	PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145.
transcription factor target	36620589	hsa-mir-194	Gastrointestinal Neoplasms	Our finding highlights that miR-194 exerts a tumor-suppressive role in digestive system cancers by targeting ATP6V1F, PPP1R14B, BTF3L4 and SLC7A5.
target gene	36620570	hsa-mir-7705	Stomach Neoplasms	hsa_circ_0061276 may be a new biomarker for gastric cancer. The tumor suppressor role of hsa_circ_0061276 on gastric cancer likely occurs through a sponge effect on miRNAs such as hsa-miR-7705.
circulation_biomarker_diagnosis_up	36620222	hsa-mir-486	Cerebral Palsy	Interestingly, miR-486 was upregulated 2-fold in the EVs of CP vs. TD both at baseline and after exercise. Our data suggest that circulating miR-486 transported by EVs is elevated in individuals with CP and that miR-486 alters the transcriptome of myoblasts affecting both ECM- and sarcomerogenesis-related genes, providing a link to the skeletal muscle alterations observed in individuals with CP.
lncRNA target	36619898	hsa-mir-197	Lymphoma, B-Cell	5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-kappaB signaling pathway and might impact the apoptosis and signal transduction of DLBCL.
exosome	36619870	hsa-mir-191	Uveal melanoma	Additionally, the comparison of miRNA expression levels in exosomes derived from UM patients with those derived from healthy donors revealed that hsa-miR
lncRNA target	36619232	hsa-mir-122	Carcinoma, Hepatocellular	Rescue experiments showed that RPPH1 acted as a competing endogenous RNA (ceRNA) by sponging miR-122 in HCC cells. Our study demonstrates for the first time that RPPH1 promotes HCC progression via the miR-122/Wnt1/beta-catenin axis, which may represent a valuable therapeutic target for patients with HCC.
transcription factor target	36619199	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	The present study aimed to observe the effects of ECC-BYF III in a COPD rat model and dissect its potential mechanisms in regulating mucus hypersecretion via the miR-146a-5p/epidermal growth factor receptor (EGFR)/MEK/ERK pathway. The protective effect of ECC-BYF III in reducing airway mucus hypersecretion in COPD may involve the miR-146a-5p/EGFR/MEK/ERK pathway.
target gene	36618816	hsa-mir-363	Lymphoma, T-Cell	MiR-363 suppresses the tumor growth of natural killer/T-cell lymphoma via the SIRT6/PI3K/AKT axis.
lncRNA target	36618771	hsa-let-7a	Carcinoma, Hepatocellular	Chol-let-7a had some off-target effects, such as mild acute hepatitis-like inflammation and non-specific drug-induced kidney injury.
genetics_knock down_promote	36618768	hsa-mir-576	Thyroid Cancer, Papillary	5p was significantly overexpressed in PTC tissues and TPC-1 cells.
circulation_biomarker_diagnosis_ns	36618534	hsa-mir-15b	Obesity	Effects of Two Different School-Based Training on Serum miR15b Expression and BACKGROUND: Some circulating microRNAs, such as miR15b, are predictors of diseases associated with adulthood obesity. This study aimed to evaluate the effect of two selected school-based and high-intensity interval training (HIT) on miR15b expression and lipid profile of obese adolescents.
circulation_biomarker_diagnosis_ns	36618355	hsa-let-7i	Malaria	We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products.
circulation_biomarker_diagnosis_ns	36618355	hsa-mir-451a	Malaria	We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products.
other	36618264	hsa-mir-20	Hyperglycemia	In conclusion, in DM-induced cardiac injury, miR-320 and CD36 mutually enhance each other's expression, leading to a positive feedback loop and a sustained hyperlipidemic state in the heart.
other	36618263	hsa-mir-7	Brain Ischemia	Overall, our findings imply that CDR1as reconstitution is neuroprotective after stroke, probably by protecting miR-7 and preventing alpha-Syn-mediated neuronal death.
genetics_knock down_promote	36617978	hsa-mir-1205	Carcinoma, Hepatocellular	Furthermore, CSNK2B significantly promoted HCC cell proliferation, and CSNK2B overexpression or knockdown attenuated the effects of miR-1205 overexpression or inhibition on HCC cell viability, respectively.
other	36617839	hsa-mir-34a	Asthma	CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management.
other	36617839	hsa-mir-125b	Asthma	CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management.
lncRNA target	36617735	hsa-mir-513a	Urinary Bladder Neoplasms	Mechanistically, circHGS functions as a sponge of miR-513a-5p to elevate VEGFC expression and activate the AKT/mTOR signaling pathway, ultimately promoting BCa progression. Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa.
lncRNA target	36617513	hsa-mir-578	Breast Neoplasms	Circ_0048764 depletion suppressed the proliferative, migrative, and invasive abilities of BC cells, which was rescued by transfection of miR-578 inhibitors.
transcription factor target	36617469	hsa-mir-10b	Adenocarcinoma of Lung	RESULTS: The expression of miR-10b was up-regulated in non-small cell lung cancer, and miR-10b inhibitor could inhibit the proliferation of A549 cell.
other	36617199	hsa-mir-93	Endometriosis	CONCLUSION: VEGFA and MMP3 expression levels trended to be increased in both eutopic and ectopic endometrial tissues of endometriosis women, while down-regulation of miR-93 might be involved in the alteration of VEGFA and MMP3 in endometriosis.
target gene	36615779	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a.
circulation_biomarker_diagnosis_ns	36615122	hsa-mir-342	Breast Neoplasms	Furthermore, we examined three plasma miRNAs in BC patients (n = 108) and healthy subjects (n = 103) by RT-PCR, namely, hsa-miR
other	36615083	hsa-mir-200c	COVID-19	Here, we investigated miRNA-200c as a potential marker for the prediction of the severity of COVID-19 to preventively initiate and personalize therapeutic interventions in the future. Our study provides the basis for further evaluation of miRNA-200c as a predictive biomarker for the progress of COVID-19.
other	36614208	hsa-mir-15a	Memory Disorders	This study investigated the potential of Dex to mitigate MTX-induced neurotoxicity and memory impairment in rats and the possible role of the miR-15a/ROCK-1/ERK1/2/CREB/BDNF pathway.
lncRNA target	36614110	hsa-mir-200c	Esophageal Achalasia	Taking into account our previous results on the downexpression of miR-200c-3p in tissues of patients with achalasia correlated with an increased expression of PRKG1, SULF1, and SYDE1 genes, our aim was to explore the unknown biological interaction between these genes and human miR-200c-3p and if this relation could unravel their functional role in the etiology of achalasia. Our study provides, for the first time, functional evidence about the PRKG1 gene as a direct target and SULF1 and SYDE1 as potential indirect substrates of miR-200c-3p and suggests the involvement of NO/cGMP/PKG signaling in the pathogenesis of achalasia.
genetics_overexpression_suppress	36614061	hsa-mir-423	Prostatic Neoplasms	Pathway enrichment analysis revealed that stable overexpression of miR
circulation_biomarker_diagnosis_ns	36613908	hsa-mir-101	Ovarian Neoplasms	The relative levels of miR-24 and miR-101 in plasma exosomes of HFs were significantly higher than in plasma exosomes of OC patients, while the levels of these microRNAs in exosomes from plasma and ascites of ill females showed no difference.
other	36613808	hsa-mir-221	Breast Neoplasms	Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro.
other	36613808	hsa-mir-9	Breast Neoplasms	Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro.
genetics_GWAS	36613718	hsa-mir-155	Mycosis Fungoides	The purpose of this study is to evaluate the plasma levels of miR-146a and miR-155 in MF patients and to investigate their association with SNPs of their genes.
other	36613642	hsa-mir-142	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-219a-2	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-199b	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-219a	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-199a	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-9	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-124	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
other	36613642	hsa-mir-129-2	Carcinoma, Non-Small-Cell Lung	5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-223	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-4454	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
circulation_biomarker_diagnosis_ns	36613584	hsa-mir-142	Obesity	5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22).
other	36613546	hsa-mir-500a	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-500a	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-206	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-206	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-548c	Ischemic Attack, Transient	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613546	hsa-mir-548c	Ischemic Stroke	3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients.
other	36613525	hsa-mir-375	Non-alcoholic Fatty Liver Disease	Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis.
other	36613525	hsa-mir-34a	Non-alcoholic Fatty Liver Disease	Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis.
other	36612284	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	MiR-21 did not show any variation among groups; miR-27b was under-expressed in dysplastic lesions (p = 0.046); miR-181b was upregulated in high-grade dysplasia (p = 0.006), increasing with the degree of dysplasia, and decreasing in OSCCs.
other	36612284	hsa-mir-181b	Squamous Cell Carcinoma of Head and Neck	(4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia.
other	36612284	hsa-mir-27b	Squamous Cell Carcinoma of Head and Neck	(4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia.
circulation_biomarker_diagnosis_ns	36612201	hsa-let-7d	Carcinoma, Hepatocellular	In our Chinese cohorts, three serum-exosome-derived miRNAs (miR
circulation_biomarker_diagnosis_ns	36612201	hsa-mir-122	Carcinoma, Hepatocellular	In our Chinese cohorts, three serum-exosome-derived miRNAs (miR
lncRNA target	36612120	hsa-mir-545	Carcinoma, Renal Cell	Mechanistically, we found that circ-PRKCI promoted the proliferation of RCC via the miR3p/CCND1 signaling pathway.
genetics_knock down_promote	36611966	hsa-mir-21	Carcinoma, Renal Cell	5p inhibitor suppressed the cell growth and cell invasion of ACHN and OSRC-2 cells, which could be compensated by FDX1 knockdown, reinforcing the functional linkage between miR
transcription factor target	36611916	hsa-mir-21	proliferative diabetic retinopathy	This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR.
transcription factor target	36611916	hsa-mir-125	proliferative diabetic retinopathy	This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR.
other	36611869	hsa-mir-497	Parkinson Disease	5p in PD contributes to enhanced progressive neurodegeneration of PD patients.
genetics_overexpression_suppress	36611865	hsa-mir-7	Pancreatitis	The overexpressed SNHG11/miR
transcription factor target	36611425	hsa-mir-146a	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
transcription factor target	36611425	hsa-mir-155	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
transcription factor target	36611425	hsa-mir-221	COVID-19	We found here that CDKN1B gen is a shared target of miR-146a, miR
circRNA target	36611218	hsa-mir-184	Osteosarcoma	5p/EGFR pathway, indicating that circEMB may serve as a therapeutic target for OSA.
other	36611161	hsa-mir-15b	Pulmonary Fibrosis	In addition, increased expression of miRNA15b was identified with decreased expression of Smurf2 mRNA in PF models.
other	36610331	hsa-mir-197	Osteoarthritis	RESULTS: OA tissues and model cells had higher abundance of circ_0003800 and SOX5, while miR3p content was lower.
transcription factor target	36610147	hsa-mir-195	Ovarian Neoplasms	CONCLUSION: Both in vitro and in vivo data demonstrated that TSN could reduce DDP resistance in OC through regulating the miR-195/ERK/beta-catenin pathway, highlighting the potential of TSN as an effective agent for favoring overcoming clinical DDP resistance in OC.
circulation_biomarker_diagnosis_ns	36609569	hsa-mir-6750	Nasopharyngeal Carcinoma	Here, we detected miR-6750, the precise molecular function of which was largely unknown, was significantly enriched in serum-SEVs from normal volunteers vs. patients with nasopharyngeal carcinoma (NPC).
circulation_biomarker_diagnosis_down	36609531	hsa-mir-339	Acute Kidney Injury	5p expression was downregulated in the blood of septic AKI patients, and miR
exosome	36609437	hsa-mir-598	Carcinoma, Non-Small-Cell Lung	In the present study, we sought to define the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-598 in NSCLC.
lncRNA target	36609391	hsa-mir-23b	Esophageal Neoplasms	Hsa_circ_0021727 promoted ESCC progression by activating TAB1/NFkappaB pathway by sponging miR-23b-5p. In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway.
lncRNA target	36609253	hsa-mir-141	Intervertebral Disc Degeneration	CONCLUSION: PLGA microspheres coloaded with TGF-beta1 and anti-miR-141 can reverse IDD by inhibiting the degeneration of NPCs.
other	36609154	hsa-mir-129	Memory Disorders	BACKGROUND: SAHA was reported to enhance the expression of miR5p, which was predicted to bind to 3' UTR of CASP-6, a gene playing crucial roles in the pathogenesis of memory impairment.
transcription factor target	36608839	hsa-mir-155	Hypoxia-Ischemia, Brain	Together, our results demonstrated that miR-155 exerted a negative effect in HIBD by targeting SIRT1, which could contribute to the treatment of neonatal patients with hypoxic-ischemic brain damage.
lncRNA target	36608833	hsa-mir-940	Ischemic Stroke	CONCLUSION: Depletion of circ_0006459 protected human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through miR-940/FOXJ2 pathway, providing a promising therapeutic target for ischemic stroke.
circRNA target	36608542	hsa-mir-384	Carcinoma, Renal Cell	miR-384 inhibitor transfection attenuated the inhibiting impacts of circ_0101692 silencing on ccRCC cell progression.
genetics_knock down_suppress	36608447	hsa-mir-373	Osteoarthritis	CONCLUSION: Our data confirmed that circ_0001721 knockdown alleviated IL-1beta-induced chondrocyte injury by miR3p/CXCR4 axis, which suggested that circ_0001721 might be a potential therapeutic target for OA.
genetics_overexpression_suppress	36607951	hsa-mir-154	Carcinoma, Pancreatic Ductal	In rescue assays, KPNA4 overexpression or miR
other	36607643	hsa-mir-872	Spinal Cord Ischemia	In conclusion, SCIRI in vivo and OGD/R in vitro stimulated the miR5p/FOXO3a/beta-catenin-TCF4 pathway, thereby promoting NSC proliferation.
lncRNA target	36607481	hsa-mir-195	Carcinoma, Hepatocellular	5p targeted CDK1 and repressed synthesis of new DNA in HCC cells, thus restraining HCC cell proliferation.
genetics_overexpression_promote	36607163	hsa-mir-612	Nasopharyngeal Carcinoma	overexpression-induced repression of the migration, adhesion, and proliferation of NPC cells via the activation of the PI3K/AKT pathway.
lncRNA target	36606668	hsa-mir-148a	Uterine Cervical Neoplasms	The Human papillomavirus E6 protein might reduce the expression of miR-148a-3p, relieve the inhibitory effect of miR-148a-3p on LIPG expression, and promote the progression of cervical cancer through the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B/mechanistic target of rapamycin kinase signalling pathway.IMPACT STATEMENTWhat is already known on this subject? LIPG provides lipid precursors, suggesting that it might function in the metabolism of carcinoma cellsWhat do the results of this study add? LIPG might be regulated by HPV16 E6/miR-148a-3p and promote cervical carcinoma progression via the PI3K/AKT/mTOR signalling pathway.What are the implications of these finding for clinical practice and/or further research? The results indicated that novel treatment and diagnosis strategies for cervical carcinoma could be developed related to LIPG.
other	36606643	hsa-let-7i	Ischemic Stroke	We selected five miRNAs (miR-17, miR-93, miR-450, miR-629, and let-7i) related to atherosclerosis based on a literature review. CONCLUSIONS: The expression level of let-7i was independently related to arterial stiffness in patients with cerebral infarction, suggesting that it plays a pathophysiological role in atherosclerosis.
lncRNA target	36606578	hsa-mir-145	Thyroid Cancer, Papillary	3p that targeted TGFBR2 and USP15, both of which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC.
other	36606461	hsa-mir-144	Obesity	Bivariate GWAS analysis found MIR144 gene and its related biological pathways may influence obesity and lipid levels.
circulation_biomarker_diagnosis_down	36606278	hsa-mir-29b	Sarcopenia	Moreover, we used real-time RT-PCR to measure the abundance of the CVRF-related miRNAs in the plasma of a cohort of 93 control and sarcopenia individuals, including miR-29b, miR-181a, and miR-494. We found that plasma miR-29b levels were significantly down-regulated in response to sarcopenia in the elderly with CVRF.
other	36606191	hsa-mir-143	Prostatic Neoplasms	miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer.
other	36605803	hsa-mir-146a	Diabetes Mellitus	Our previous studies have shown the ability of a cerium oxide nanoparticle (CNP) formulation conjugated with the anti-inflammatory microRNA miR146a (CNP-miR146a) to enhance the healing of diabetic wounds. Comparison with miR146a conjugated gold (bioactive, metal) and silica (bioinert, oxide) nanoparticles (AuNPs and SiO(2)NPs) was performed in the presence of H(2)O(2), as an analogue to the high levels of ROS present in the diabetic wound environment.
target gene	36605483	hsa-mir-22	Liver Neoplasms	Long noncoding RNA DSCR8 promotes the proliferation of liver cancer cells and inhibits apoptosis via the miR-22-3p/ARPC5 Axis.
genetics_knock down_promote	36605481	hsa-mir-653	Colorectal Neoplasms	Moreover, miR-653 served as carcinoma-promoting gene via targeting KLF6, and circSETD3 knockdown significantly reversed the inhibitory effect of KLF6 overexpression on CRC cells.
circulation_biomarker_diagnosis_ns	36604945	hsa-mir-181a	Osteoporosis	RESULTS: miR-181a-5p was highly expressed in the serum of osteoporosis patients.
lncRNA target	36604807	hsa-mir-486	Atrial Fibrillation	5p expression and had a potential targeting relationship with miR
lncRNA target	36604774	hsa-mir-3158	Migraine Disorders	5p via CNVs to modulate the mechanism of pain.
lncRNA target	36604774	hsa-mir-548e	Migraine Disorders	CNVs, the Cholinergic Receptor Nicotinic Alpha 7 Subunit (CHRNA7) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n = 120) aged 15-60 years, comparative, case-control study was conducted.
lncRNA target	36604721	hsa-mir-340	Osteosarcoma	CONCLUSION: FGF23 promotes osteosarcoma cell proliferation, migration and invasion by targeting miR5p gene expression.
circulation_biomarker_diagnosis_up	36604580	hsa-mir-484	Graves Ophthalmopathy	5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.
circulation_biomarker_diagnosis_up	36604580	hsa-mir-192	Graves Ophthalmopathy	5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.
target gene	36604405	hsa-mir-486	Thyroid Neoplasms	Circ_0124055 promotes the progression of thyroid cancer cells through the miR-486-3p/MTA1 axis.
lncRNA target	36604379	hsa-mir-8881	Charcot-Marie-Tooth disease type 1B	The aim of this study was to investigate the effects of lncRNA34977 on the proliferation, migration, invasion, and apoptosis of canine mammary tumor (CMT) cells through the regulation of miR-8881/ELAVL4 expression. Our study shows that lncRNA34977 promotes the proliferation, migration, and invasion and suppresses the apoptosis of CMT cells by regulating the expression of miR-8881/ELAVL4.
other	36603835	hsa-mir-223	Coronary Artery Disease	3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST.
transcription factor target	36603462	hsa-mir-342	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
transcription factor target	36603462	hsa-mir-150	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
transcription factor target	36603462	hsa-mir-142	Atrial Premature Complexes	3p in contributing NHT-R by targeting CREB5 in PCa.
other	36603443	hsa-mir-122	Breast Neoplasms	In the perusal, a novel electrochemical biosensor amplified with hierarchical flower-like gold, poly (n-butyl acrylate), and MXene (AuHFGNs/PnBA-MXene) nanocomposite and activated by highly special antisense ssDNA (single-stranded DNA) provide a promising alternative for miRNA-122 detection as a biomarker of breast cancer.
lncRNA target	36603340	hsa-mir-200c	Retinoblastoma	Our results demonstrate that miRNA-200c-3p inhibits EMT progression through the Wnt16/beta-catenin/ZEB1/E-cadherin axis, and the ZEB1 silencing response shows that miR-200c-3p regulates ZEB1-mediated EMT in retinoblastoma.
lncRNA target	36602696	hsa-mir-124	Stomach Neoplasms	HRCT1, negatively regulated by miR3p, may be a potential therapeutic target for patients with gastric cancer.
lncRNA target	36602629	hsa-mir-143	Diabetes Mellitus, Type 2	Collectively, lncRNA UCA1 inhibited mitochondrial dysfunction of skeletal muscle in T2DM by sequestering miR3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM.
lncRNA target	36602629	hsa-mir-143	Mitochondrial Diseases	3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM.
genetics_overexpression_promote	36602424	hsa-mir-25	Carcinoma, Non-Small-Cell Lung	Accordingly, overexpression of circ_BLNK improved DDP sensitivity of NSCLC cells via miR
lncRNA target	36602216	hsa-mir-122	Carcinoma, Hepatocellular	Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC.
lncRNA target	36602216	hsa-mir-122	Hepatitis C	Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC.
circulation_biomarker_diagnosis_up	36601739	hsa-mir-92a	Coronary Restenosis	The serum miR92a expression levels were significantly higher in patients with instent restenosis (ISR) compared with those in patients without ISR, whereas KLF4 expression was significantly reduced in the nonISR group.
lncRNA target	36601671	hsa-mir-130a	Inflammation	It was demonstrated that Pue induced the expression of miR-130a-5p, which suppressed the activity of HMGB2/NF-kappaB, contributing to the attenuation of infarct heart tissues.
other	36601516	hsa-mir-7	Endometrial Hyperplasia	CONCLUSION: We concluded that miR5p attenuates vascular smooth muscle cell migration and intimal hyperplasia after vascular injury by NF-kB signaling.
transcription factor target	36600989	hsa-mir-193b	Carcinoma, Hepatocellular	Enforced CDK1 expression attenuated miR-193b-3p-modulated suppressive actions on HCC cell proliferation and migration.
genetics_overexpression_promote	36600625	hsa-mir-375	Uterine Cervical Neoplasms	Besides, miR-375 was revealed to be a downstream target of circ_0002762, and miR-375 overexpression counteracted the promoting effects of circ_0002762 overexpression on CC cell viability and migration.
exosome	36600320	hsa-mir-124	Carcinoma, Non-Small-Cell Lung	3p significantly suppressed metastasis through extracellular exosome transport and intracellular PI3K/AKT signaling.
target gene	36599973	hsa-mir-206	Osteosarcoma	LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells.
target gene	36599932	hsa-mir-144	Liver Neoplasms	ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
genetics_overexpression_suppress	36599649	hsa-mir-139	Colonic Neoplasms	3p silencing or CDK16 overexpression abolished the inhibitory effects of baicalin on colon cancer proliferation.
circRNA target	36598961	hsa-mir-582	Leukemia, Myeloid, Acute	CONCLUSION: Our findings identify that suppression of circ_0003256 impedes the malignant behaviors of pediatric AML cells by regulating PRKACB expression by competing for shared miR3p.
other	36598779	hsa-mir-574	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
other	36598779	hsa-mir-133a	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
other	36598779	hsa-mir-27a	Colorectal Neoplasms	3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.
genetics_overexpression_promote	36598700	hsa-mir-342	Pre-Eclampsia	5p antagomir, and overexpressing PDCD4 (oe-PDCD4) vector into the placenta on the 16th day of pregnancy.
epigenetics	36598670	hsa-mir-129-2	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-1258	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-339	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-137	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-124-2	Carcinoma, Non-Small-Cell Lung	A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma.
epigenetics	36598670	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	Significant differences in the level of methylation of MIR124-2 and MIR375 genes were revealed for smoking patients with squamous cell lung cancer.
genetics_knock down_promote	36598315	hsa-mir-568	Carcinoma, Hepatocellular	Also, circ_0097009 knockdown blocked tumor growth in vivoCONCLUSION: Together, this study indicated that the oncogenic function of circ_0097009 in HCC, and circ_0097009/miR-568/RNF38 axis was expected to be a novel therapeutic option for HCC patients (Tab.
lncRNA target	36598302	hsa-mir-146a	Myocardial Reperfusion Injury	METHODS: The expression levels of SOX2-OT and miR-146a-5p in OGD/R-treated H9C2 cells and in myocardial tissues of MIRI rats were measured by qRT-PCR. CONCLUSIONS: Silencing of SOX2-OT relieved the apoptosis, inflammation, and oxidative stress of myocardial cells via up-regulating miR-146a-5p, contributing to the remission of MIRI (Fig.
transcription factor target	36598122	hsa-mir-155	Bone Diseases	Thus, Mir155 showed a catabolic effect on osteogenesis and bone mass phenotype via interaction with the S1pr1 gene, suggesting inhibition of Mir155 as a potential strategy for bone regeneration and bone defect healing.
genetics_knock down_suppress	36597907	hsa-mir-181a	Ovarian Neoplasms	In this study, the CCMV VLP was applied to encapsulate two different formats of anti-miR-181a oligonucleotides: naked RNA and chemically stabilized RNA to knockdown highly regulated miR-181a in ovarian cancer cells.
other	36597862	hsa-mir-335	Osteosarcoma	METHODS: In the current work, the expression of circUSP48, miR-335 and SNIP1 in OS cell lines and tissues were evaluated using qRT-PCR. Importantly, circUSP48 promoted OS malignancy by sponging miR-335 to upregulate SNIP1.
other	36597856	hsa-mir-498	Stomach Neoplasms	Moreover, hsa_circ_0001944 sponged miR-498 to increase GSPT1 expression, thereby promoted excessive proliferation and maintained the malignant phenotype of GC cells. CONCLUSION: The present study demonstrates the hsa_circ_0001944/miR-498/GSPT1 axis contributes to GC development.
circRNA target	36597773	hsa-mir-370	Acute Kidney Injury	Conclusion: Our data demonstrated that circ_0114428 contributed to septic AKI progression by regulating miR3p-mediated TIMP2 expression, which provided a promising target for septic AKI treatment.
other	36597599	hsa-mir-223	Sjogren's Syndrome	MiR3p increased while ITPR3 decreased in samples from SS patients and INF-gamma-induced SGECs.
circulation_biomarker_diagnosis_ns	36597468	hsa-mir-143	Diabetes Mellitus, Type 2	CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention.
circulation_biomarker_diagnosis_ns	36597468	hsa-mir-145	Diabetes Mellitus, Type 2	CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention.
genetics_overexpression_promote	36597176	hsa-mir-34	Hepatitis B, Chronic	Overexpression of pHBV(1.3) further confirmed that HBV downregulates miR-34 expression.
genetics_overexpression_suppress	36597175	hsa-mir-138	Carcinoma, Non-Small-Cell Lung	Moreover, overexpression of SNIP1 rescues the miR
other	36596777	hsa-mir-29a	Leukemia, Promyelocytic, Acute	APA exerts this effect by shortening the 3'UTRs of the Col1a1 and Col1a2 mRNAs, thus removing the binding sites of miR-29a-3p, which would otherwise strongly promote the degradation of both transcripts.
genetics_overexpression_suppress	36596504	hsa-mir-137	Spinal Cord Injuries	overexpressing BMMSC exosomes may serve as a treatment option for SCI recovery.
circulation_biomarker_diagnosis_ns	36596338	hsa-mir-548n	Aortic Aneurysm, Abdominal	CONCLUSION: Serum let-7b-5p and miR548n significantly improved the ability to diagnose AAA.
other	36596006	hsa-mir-149	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-196a-2	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-499	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
other	36596006	hsa-mir-146a	Ischemic Stroke	The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model.
target gene	36595346	hsa-mir-455	Pancreatic Neoplasms	IL-6 Accelerates the Proliferation and Metastasis of Pancreatic Cancer Cells via the miR-455-5p/IGF-1R Axis.
exosome	36595161	hsa-mir-138	Alzheimer Disease	In the present study, both in vitro and vivo experiments were employed, and we found Catalpol (Ca), the main extract of Rehmannia, could mitigate AD progression both in vitro and in vivo by promoting miR5p level in neural stem cell secreted exosomes.
circulation_biomarker_diagnosis_ns	36594832	hsa-mir-21	Stroke	The increase in miR-21a-5p secretion may have biomarker potential, as high blood levels of miR5p in stroke patients were associated with significant disability at hospital discharge.
lncRNA target	36594718	hsa-mir-139	Carcinoma, Hepatocellular	CONCLUSION: Matrine inhibited HCC cell malignancy through the circ_0013290/miR
circulation_biomarker_prognosis_down	36594100	hsa-mir-1275	Breast Neoplasms	We found that miR-1275 was significantly downregulated in plasma from patients resistant to chemotherapy and in chemoresistant BC cell lines, while patients with low levels of miR-1275 showed poor overall survival.
genetics_overexpression_promote	36594050	hsa-mir-15a	Carcinoma, Hepatocellular	Moreover, miR-15a-5p overexpression reversed the hsa_circ_0006988-mediated SOR-R and enhanced IGF1 levels in HCC cells.
other	36593966	hsa-mir-217	Periodontitis, Diabetic	Finally, antagomiR-217, a miRNA antagonism, was delivered into the periodontium to treat LIP-induced diabetic periodontitis.
genetics_overexpression_promote	36593867	hsa-mir-1258	Carcinoma, Non-Small-Cell Lung	miR-1258 overexpression weakened the effect of circ_0000520 overexpression on NSCLC cells.
other	36593510	hsa-mir-146a	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593510	hsa-mir-133b	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593510	hsa-mir-16	Asthma	RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased.
other	36593385	hsa-mir-31	Uterine Cervical Neoplasms	LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p.
transcription factor target	36593242	hsa-mir-149	Colorectal Neoplasms	In conclusion, our findings not only highlight the significance of DDX17 in the aggressive development and prognosis of CRC patients, but also reveal a novel mechanism underlying DDX17-mediated CRC cell metastasis and EMT progression through manipulation of the miR
genetics_GWAS	36593103	hsa-mir-223	Carcinoma, Hepatocellular	RESULTS: Genetic deletion of miR-223 markedly exacerbated tumourigenesis in inflammation-associated HCC.
lncRNA target	36592647	hsa-mir-582	Inflammation	5p attenuated the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 through suppressing the degradation of the NF-kappaB inhibitor alpha, followed by the nuclear translocation of NF-kappaB.
lncRNA target	36592647	hsa-mir-582	Immune System Diseases	Therefore, exogenously applied miR5p can attenuate the NF-kappaB signaling pathway via targeting Skp1; this provides a prospective therapeutic strategy for treating inflammatory and immune diseases.
circRNA target	36592530	hsa-mir-125b	psoriasis 1	Herein our findings showed increased expression of circVAPA and Sirt6 and decreased level of miR-125b-5p in psoriatic lesional tissues and M5-stimulated keratinocytes. CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis.
genetics_GWAS	36591938	hsa-mir-492	Pancreatic Carcinoma	In this study, we first found that miR-492 in enhancer loci activated neighboring genes (NR2C1/NDUFA12/TMCC3) and promoted PaCa cell proliferation, migration, and invasion in vitro.
circulation_biomarker_diagnosis_ns	36591868	hsa-mir-10b	Breast Neoplasms	Furthermore, when PLPNs loaded with a CRISPRi plasmid that targets microRNA-10b (miR-10b) are used in combination with UMMD, it results in the effective repression of miR-10b in breast cancer, simultaneous disturbance of multiple cell migration and invasion-related signaling pathways, and a significant inhibition of lung metastasis.
other	36591806	hsa-mir-126	Prostatic Neoplasms	A high degree of MCs infiltration of the PCa tissue was associated with 1.2 times (p=0.0347) higher level of OPN expression and 1.7 (p=0.0051) and 1.65 (p=0.0087) times lower levels of miR-126 and miR-181a expression, respectively.
other	36591804	hsa-mir-3163	Uterine Cervical Neoplasms	Taken together, high expression of lncRNA CBR3-AS1 predicts poor prognosis in cervical cancer, and the lncRNA CBR3-AS1/miR-3163/LASP1 pathway plays a vital function in the modulation of cervical cancer cell proliferation and cancer stem cell-like properties.
lncRNA target	36591727	hsa-mir-495	Carcinoma, Non-Small-Cell Lung	3p/CCND1 axis, highlighting a promising target for NSCLC patients.
other	36591654	hsa-mir-662	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-4501	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-1258	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
other	36591654	hsa-mir-7705	Breast Neoplasms	A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model.
exosome	36591520	hsa-mir-320d	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
exosome	36591520	hsa-mir-4479	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
exosome	36591520	hsa-mir-6763	Carcinoma, Ovarian Epithelial	Subsequently, exosomal miR-320d, miR-4479, and miR
other	36591476	hsa-mir-221	Uterine Cervical Neoplasms	3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2).
other	36591476	hsa-mir-205	Uterine Cervical Neoplasms	3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2).
virus_miRNA	36591247	hcmv-mir-US33	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-UL112	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US5	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US29	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
virus_miRNA	36591247	hcmv-mir-US4	Fever	hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients
other	36590967	hsa-mir-338	Pulmonary Disease, Chronic Obstructive	"3p correlated with airway eosinophilia and were able to distinguish ""pure eosinophilic"" COPD from other airway inflammatory subtypes (AUC 0.94 and 0.85, respectively)."
lncRNA target	36590397	hsa-mir-1	Colitis	Further analysis reveals that the number of proliferative epithelial cells, which characterizes the inflammatory process and the recovery of epithelia in colitis, is mainly determined by the inhibition of MIR31 on IL17RA.
lncRNA target	36590309	hsa-mir-361	Esophageal Neoplasms	Silencing the target genes of miR
target gene	36589606	hsa-mir-20a	Arthritis, Rheumatoid	LncRNA cardiac autophagy inhibitory factor is downregulated in rheumatoid arthritis and suppresses the apoptosis of fibroblast-like synoviocytes by promoting the maturation of miRNA-20a.
circulation_biomarker_diagnosis_up	36588450	hsa-mir-16	Arthritis, Rheumatoid	We aimed to evaluate miR-223 and miR-16 roles in monitoring RA activity and to investigate if there is a link between their plasma levels and US7 score.
other	36588450	hsa-mir-223	Arthritis, Rheumatoid	miR-16 and miR-223 levels were correlated with synovitis PDUS7 (r = 0.34, p < 0.01 and r= 0.25, P = 0.03, respectively). The miR-16 level was linked to synovitis GSUS7 and synovitis PDUS7 changes but miR-223 only linked to synovitis PDUS.
genetics_knock down_promote	36588357	hsa-mir-142	Liver Neoplasms	Injection with sh-CRNDE virus reduced in vivo tumor growth of liver cancer through up-regulation of miR-142 and down-regulation of EZH2 and HIF-1alpha. In conclusion, knockdown of CRNDE suppressed cell proliferation, glycolysis, and tumor growth of liver cancer through EZH2/miR-142/HIF-1alpha.
lncRNA target	36587882	hsa-mir-15	Inflammation	CONCLUSION: Collectively, our study revealed the previously undefined mechanistic role of Kabasura Kudineer (KK) that alleviates the LPS-induced oxidative damage associated with inflammation by inhibiting the miRNA5p/IL-10Ralpha axis.
other	36587497	hsa-mir-451a	Placenta Diseases	Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders.
other	36587497	hsa-let-7d	Placenta Diseases	Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders.
other	36587063	hsa-mir-28	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-203a	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-1	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-378a	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-203a	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-378a	Dermatitis, Atopic	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-1	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
other	36587063	hsa-mir-28	psoriasis 1	5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients.
genetics_overexpression_promote	36587050	hsa-mir-125a	ankylosing spondylitis 1	Accordingly, poorly expressed MEG3 and TNF alpha induced protein 3 (TNFAIP3) as well as overexpressed microRNA-125a-5p (miR-125a-5p) were noted in the serum of AS patients and in ASMSCs during the osteogenic induction process.
circulation_biomarker_diagnosis_ns	36586536	hsa-mir-96	Polycystic Ovary Syndrome	Furthermore, we demonstrated that the elevated circulating miR
genetics_knock down_promote	36586093	hsa-mir-1299	Carcinoma, Non-Small-Cell Lung	MiR-1299 inhibitor reversed circ_0020123 knockdown-mediated influence on malignant behaviors of NSCLC cells under TSIIA treatment.
lncRNA target	36586008	hsa-mir-361	Esophageal Neoplasms	3p or COL5A1 axis, indicating that BBOX1-AS1 might be a potential therapeutic target for EC therapy.
circulation_biomarker_diagnosis_ns	36585554	hsa-mir-188	Vascular Diseases	3p), and toll-like receptor 4 (TLR4) expression was determined via real-time quantitative polymerase chain reaction (RT-qPCR) in serum samples from AS patients and healthy volunteers.
other	36585230	hsa-mir-181c	Lung Neoplasms	Results UALCAN analysis displayed that the expression of miR-181c was significantly higher and RECK expression was significantly lower in lung cancer tissues compared to that in normal tissues.
other	36585203	hsa-mir-1	Glioblastoma	CONCLUSION: Our results demonstrated that NIPP is able to efficiently attenuate growth of GBM cells and suggest AKT1, ERK1/2 and miR-1 to be pivotal factors of NIPP-modulated cellular signalling.
transcription factor target	36585184	hsa-mir-877	Esophageal Squamous Cell Carcinoma	3p acts as a tumour suppressor gene in ESCC cells, and its down-regulation in ESCC tissues is associated with a poor prognosis.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4500	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-5191	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-5587	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-4469	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4803	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-5680	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4666a	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-4661	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
other	36584787	hsa-mir-183	Urticaria	RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients.
circulation_biomarker_diagnosis_ns	36584787	hsa-mir-382	Urticaria	3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects.
lncRNA target	36584452	hsa-mir-16	Inflammation	CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis.
lncRNA target	36584452	hsa-mir-16	Sepsis	CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis.
genetics_knock down_suppress	36583803	hsa-mir-29c	Carcinoma, Hepatocellular	CONCLUSION: miR-29c, a key gene regulating HCC, is lowly expressed in HCC, its overexpression can remarkably inhibit the biological function of tumor cells.
genetics_overexpression_suppress	36583788	hsa-mir-758	Uterine Cervical Neoplasms	3p overexpression on CC cell progression.
lncRNA target	36583714	hsa-mir-34a	Liver Cirrhosis	The miR-34a-mediated ductular reactions may be functioning through Sirt
lncRNA target	36583660	hsa-mir-27a	Thyroid Cancer, Papillary	Our study highlights that DNAJC3-AS1 inhibits miR-27a-3p to promote CCBE1 expression, thereby facilitating PTC development.
genetics_overexpression_promote	36583484	hsa-mir-101	Carcinoma, Non-Small-Cell Lung	3p weakened the promoting effect of overexpressed KPNA2 on LUSC malignant progression.
other	36583233	hsa-mir-15b	Coronary Artery Disease	RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups.
other	36583233	hsa-mir-15b	Heart Failure	RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups.
other	36583003	hsa-mir-4732	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-4732	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-631	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-513b	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-513b	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-631	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-1180	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-let-7b	Adenoma	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-let-7b	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-1180	Bulbospinal neuronopathy, X-linked recessive	5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively).
other	36583003	hsa-mir-6805	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-548av	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-548av	Adenoma	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
other	36583003	hsa-mir-6805	Bulbospinal neuronopathy, X-linked recessive	Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma.
genetics_GWAS	36582685	hsa-mir-216a	Colonic Neoplasms	In conclusions, lnc-LAMC2-1:1 SNP rs2147578 was involved in promoting COAD progression by targeting miR-216a-3p/HMGB3, and this study will provide a novel molecular target for COAD.
exosome	36582605	hsa-mir-122	Thyroid Neoplasms	Cancer stem cell-like cells-derived exosomal lncRNA CDKN2B-AS1 promotes biological characteristics in thyroid cancer via miR-122-5p/P4HA1 axis.
other	36582505	hsa-mir-122	Chilblain lupus	METHODS: The expression of adenosine deaminase acting on RNA-1 (ADAR1) and miR-122 was evaluated in liver tissues from patients with CHB concurrent NAFLD.
genetics_overexpression_suppress	36582030	hsa-mir-700	Skin Diseases	MiR5p overexpression or GPX4 downregulation inhibited the circ-Ash1l protective effects of UV-induced endothelial progenitor cell (EPC) damage.
genetics_overexpression_promote	36581129	hsa-mir-663b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: Our study illustrated that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis.
lncRNA target	36581048	hsa-mir-124	Liver Injury	Collectively, our findings suggest that miR-124 can potentially serve as a predictive biomarker for HBV-ACLF prognosis and may represent a promising therapeutic target for relieving severe liver injury resulting from cytokine storms.
lncRNA target	36580691	hsa-mir-181b	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
lncRNA target	36580691	hsa-mir-542	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
lncRNA target	36580691	hsa-mir-3690	Depressive Disorder, Major	3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression.
circRNA target	36580535	hsa-mir-203a	Osteosarcoma	Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS.
circRNA target	36580535	hsa-mir-208b	Osteosarcoma	Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS.
other	36580437	hsa-mir-515	Pre-Eclampsia	This study tried to elicit the functional mechanism of miR5p in trophoblast cell behaviors in PE.
transcription factor target	36579994	hsa-mir-233	Carcinoma, Hepatocellular	CONCLUSIONS: Our data suggest a potential role for miR3p as a prognostic as well as a therapeutic target for HCC.
lncRNA target	36579395	hsa-mir-141	Triple Negative Breast Neoplasms	3p could suppress autophagy and inhibit proliferation, migration, and invasion by targeting Malat1 in TNBC cells under hypoxia.
other	36579331	hsa-mir-296	Sepsis	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-650	Acute Kidney Injury	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-296	Acute Kidney Injury	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
other	36579331	hsa-mir-650	Sepsis	Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI.
genetics_overexpression_suppress	36578555	hsa-mir-122	Carcinoma, Renal Cell	Overexpression of circ_DENND1B regulated TIMP2 level by inhibiting miR
lncRNA target	36578092	hsa-mir-130a	Breast Neoplasms	CONCLUSION: This study presents a mechanism involving the DSCAM-AS1/miR-130a/ESR1 genomic axis through which progesterone impedes breast cancer cell invasion and migration.
transcription factor target	36578050	hsa-mir-4443	Esophageal Squamous Cell Carcinoma	CONCLUSION: In this study, miR-4443 is found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, which provides a new perspective and clue to alleviate radioresistance.
circulation_biomarker_diagnosis_ns	36577694	hsa-mir-206	Depression	OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients. miRNA-206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS.
circulation_biomarker_diagnosis_ns	36577694	hsa-mir-206	Anxiety Disorders	OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients.
circulation_biomarker_diagnosis_up	36577155	hsa-mir-21b	Graft vs Host Disease	Th1, Th17 and Treg cells were respectively isolated from peripheral blood CD4 T cells of allo-HSCT patients, and we found that proportions of Th1 and Th17 were markedly increased, while Treg proportion was significantly decreased in aGVHD patients post transplantation compared with non-aGVHD patients, accompanied by decreased ADAR1 and increased miR-21b levels. Collectively, ADAR1 suppresses miR-21b production and improves Foxp3-mediated Treg cell function to inhibit the progression of aGVHD after allo-HSCT.
lncRNA target	36577153	hsa-mir-34a	Neuralgia	CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway.
lncRNA target	36577153	hsa-mir-34a	Spinal Cord Injuries	CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway.
circulation_biomarker_diagnosis_ns	36577123	hsa-mir-375	Liver Neoplasms	Conclusions: According to our meta-analysis, measuring serum miR-375 has high sensitivity and specificity, which will facilitate its clinical application in liver cancer monitoring.
other	36577032	hsa-mir-503	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-10a	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-let-7d	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-106b	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
other	36577032	hsa-mir-93	Diabetes Mellitus, Type 1	5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05).
target gene	36576783	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis.
target gene	36576714	hsa-mir-378a	Hepatoblastoma	LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
genetics_knock down_promote	36575638	hsa-mir-92a	Coronary Artery Disease	Loss of LPP3 in CAD is associated with an increase in the LPP3 inhibitor, miR-92a.
lncRNA target	36575638	hsa-mir-92a	Fibromuscular Dysplasia	miR-92a is elevated in CAD arterioles (fold change: 1.9 0.01 P = 0.04), while inhibition of miR-92a restored NO-mediated FMD (CAD), and enhancing miR-92a expression (non-CAD) elicited H(2) O(2) -mediated dilatation (P &lt; 0.0001). Inhibition of miR-92a restores nitric oxide-mediated FMD in the microvasculature of CAD patients.
other	36575638	hsa-mir-92a	Vascular Diseases	We investigated the role of LPP3 and miR-92a as a mechanism for microvascular dysfunction in CAD.
other	36575500	hsa-mir-122	Muscular Dystrophy, Facioscapulohumeral	3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression.
circulation_biomarker_prognosis_ns	36575500	hsa-mir-23	Muscular Dystrophy, Facioscapulohumeral	CONCLUSIONS: Although limited by the small number of patients included in this study, we propose here a specific combination of circulating miR
circulation_biomarker_diagnosis_ns	36575500	hsa-mir-23b	Muscular Dystrophy, Facioscapulohumeral	Four of these circulating miRs (miR
other	36575500	hsa-mir-192	Muscular Dystrophy, Facioscapulohumeral	3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression.
circulation_biomarker_diagnosis_ns	36575500	hsa-mir-19b	Muscular Dystrophy, Facioscapulohumeral	Four of these circulating miRs (miR
lncRNA target	36575320	hsa-mir-29a	lacrimal gland adenoid cystic carcinoma	miR-29a-3p can specifically target the 3' UTR of Quaking mRNA and down-regulate Quaking expression, thereby inhibiting the proliferation, migration, and epithelial-mesenchymal transition of LACC cells.
genetics_knock down_promote	36575008	hsa-mir-342	Carcinoma, Non-Small-Cell Lung	3p) sponge, and circ_0006220 knockdown-induced changes on the phenotypes of NSCLC cells were largely overturned by the knockdown of miR
lncRNA target	36574754	hsa-mir-19b	Carcinoma, Endometrioid	CONCLUSIONS: LINC01857 exacerbated EC cell malignant behaviors via the miR-19b-3p/ELAVL1/MYCN axis.
circRNA target	36574090	hsa-mir-142	Lung Neoplasms	Taken together, circTAB2 serves as an inhibitory role in lung cancer through a novel circTAB2 /miR-3142 /GLIS2 /AKT pathway and could be exploited a novel marker in lung cancer.
circulation_biomarker_diagnosis_up	36573890	hsa-mir-124	Inflammatory Bowel Diseases	Consistently, miR-124 expression was upregulated in the rectal biopsies and blood samples of UC patients and a parallel reduction in Th17 cells and IL17a levels was observed in serum samples.
genetics_knock down_promote	36573325	hsa-mir-548i	Carcinoma, Non-Small-Cell Lung	Moreover, miR-548I was targeted by circ_0008003, and miR-548I knockdown reversed the influence of circ_0008003 silence on NSCLC progression. CONCLUSION: Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR-548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis.
other	36573168	hsa-mir-146a	psoriasis 1	Moreover, expression levels of miR-146a-3p were higher in psoriatic HDMECs than in normal controls.
other	36573051	hsa-mir-21	Rectal Neoplasms	5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma.
other	36573051	hsa-mir-455	Rectal Neoplasms	5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma.
genetics_overexpression_suppress	36572886	hsa-mir-338	Osteoarthritis	3p silencing/overexpression) were incubated with IL-1beta-induced ATDC5 cells, followed by evaluation of the chondrocyte proliferation, degradation, and inflammation injury.
transcription factor target	36572643	hsa-mir-297	Endometriosis	METHODS: ESCs were isolated from infertile endometriosis and normal patients and were transfected with miR-297 mimic or miR-297 inhibitor or respective control.
circRNA target	36572073	hsa-mir-556	Osteosarcoma	5p inhibitor.
other	36571367	hsa-mir-138	Diabetic Neuropathies	These findings suggest that the circ_0002538/miR5p/PLLP axis can promote the migration of Schwann cells in diabetic peripheral neuropathy patients, improving myelin sheath structure and nerve function.
transcription factor target	36571232	hsa-mir-132	Colonic Neoplasms	3p regulates colon cancer cell sensitivity to antibody-mediated CDC by directly targeting CD55.
exosome	36570020	hsa-mir-181a	Lung Injury	CONCLUSION: Consequently, we concluded that ADSC-derived exosomal miR-181a-5p alleviated Klebsiella pneumonia infection-induced lung injury by targeting STAT3 signaling. ADSC-derived exosomal miR-181a-5p may serve as a potential candidate for the treatment of Klebsiella pneumonia infection-induced lung injury.
lncRNA target	36569509	hsa-mir-200a	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
lncRNA target	36569509	hsa-mir-375	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
lncRNA target	36569509	hsa-mir-200b	Teratoma	CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery.
genetics_knock down_promote	36569483	hsa-mir-215	Pulmonary Fibrosis	5p knockdown on PQ-induced pulmonary fibrosis.
lncRNA target	36569479	hsa-mir-150	Carcinoma, Non-Small-Cell Lung	We validate that RSV influences mitophagy and PTX resistance in NSCLC via ZFAS1/miR
transcription factor target	36569394	hsa-mir-211	Dyspepsia	Targeting miR-211 or the MAPK pathway may be a potential intervention for FD.
target gene	36569343	hsa-mir-3677	Leukemia, Monocytic, Acute	Ginsenoside Rk3 Inhibits the Extramedullary Infiltration of Acute Monocytic Leukemia Cell via miR-3677-5p/CXCL12 Axis.
other	36568518	hsa-mir-30	Stomach Neoplasms	DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis.
lncRNA target	36567178	hsa-mir-376b	Carcinoma, Hepatocellular	Bioinformatics analysis based on Lncbase, miRDB and TargetScan databases showed MK5-AS1 competitively bound to miR-376b-5p that prevented epithelial cell transforming sequence 2 (ECT2) from miRNA-mediated degradation, thus facilitated HCC metastasis.
exosome	36567149	hsa-mir-145	Gynatresia	Exosomal miR
exosome	36567149	hsa-mir-145	adhesions of uterus	CONCLUSIONS: UCMSC-exos might reverse endometrial stromal cell fibrosis by regulating the miR5p/ZEB2 axis, representing a potential novel strategy to promote endometrial repair.
lncRNA target	36567017	hsa-mir-205	Hashimoto Disease	Under stress conditions, such as ultraviolet radiation, we in addition show HITT stability increases as a consequence of MiR-205 downregulation, inhibiting MFN2-mediated fusion and leading to apoptosis.
transcription factor target	36566019	hsa-mir-337	Urinary Bladder Neoplasms	3p may act as a candidate therapeutic target in BC treatments.
other	36566010	hsa-mir-210	Glaucoma	3p level/activity represents a potential new therapeutic strategy for POAG.
genetics_overexpression_promote	36565612	hsa-mir-2114	Ovarian Neoplasms	Cx26 overexpression and miR
genetics_overexpression_promote	36565360	hsa-mir-4299	Pancreatic Carcinoma	ADAM17 overexpression could reverse miR-4299 effects on PC cell viability, invasion, apoptosis, and immune escape.
circulation_biomarker_diagnosis_ns	36564725	hsa-mir-338	Sepsis	RESULTS: The levels of miR3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05).
circulation_biomarker_diagnosis_ns	36564725	hsa-mir-338	Kidney Diseases	3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05).
other	36564279	hsa-mir-548aq	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
other	36564279	hsa-mir-4710	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
other	36564279	hsa-mir-367	Breast Neoplasms	3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM.
transcription factor target	36564067	hsa-mir-126	Wounds and Injuries	5p may be a molecular target for MI treatment.
lncRNA target	36564067	hsa-mir-126	Myocardial Infarction	5p may be a molecular target for MI treatment.
circRNA target	36563841	hsa-mir-351	Diabetes, Gestational	CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR
circRNA target	36563841	hsa-mir-3102	Diabetes, Gestational	CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR
other	36563751	hsa-mir-143	Glima	Brain lower and grade glioma patients who had higher levels of TP53, hsa-miR-25, hsa-miR-34, hsa-miR-222, and hsa-miR-143 had a reduced likelihood of survival.
transcription factor target	36562844	hsa-mir-338	Coronary Disease	3p may be a diagnostic biomarker and therapeutic target for coronary heart disease.
circRNA target	36562476	hsa-mir-761	Triple Negative Breast Neoplasms	In-depth mechanism analysis indicated that circDUSP1 acts as an endogenous sponge of miR-761 to reduce its suppression on target gene DACT2 expression in TNBC.
lncRNA target	36561980	hsa-mir-142	Myocardial Reperfusion Injury	3p can negatively regulate dopamine receptor D2 (DRD2), which acted as an anti-inflammatory factor to suppress NF-kappaB-dependent inflammation and prevent MIRI.
other	36561976	hsa-mir-141	Mitochondrial Diseases	MicroRNA-141 (miR-141) has been implicated in the mitochondrial dysfunction in cell-based models of oxidant stress.
other	36561887	hsa-mir-200b	Nervous System Diseases	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-200b	Schizophrenia	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Alzheimer Disease	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Nervous System Diseases	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-146a	Schizophrenia	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
other	36561887	hsa-mir-200b	Alzheimer Disease	We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms.
lncRNA target	36561847	hsa-mir-4270	Colonic Neoplasms	More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells.
lncRNA target	36561842	hsa-mir-4711	Intervertebral Disc Degeneration	Overall, silencing ZFAS1 inhibits IDD progression by reducing NP cell apoptosis and ECM degradation through the miR5p/AAK1 axis.
other	36561253	hsa-mir-218	Aortic Aneurysm, Abdominal	BACKGROUND: To explore the effects of miRNA5p on inflammation and extracellular matrix proteins of vascular smooth muscle cell line in abdominal aortic aneurysm (AAA).
other	36561136	hsa-mir-186	Alzheimer Disease	5p were determined by COX regression, AD transformation status and aberrant miRNAs.
other	36561136	hsa-mir-425	Alzheimer Disease	5p were determined by COX regression, AD transformation status and aberrant miRNAs.
circulation_biomarker_diagnosis_ns	36561056	hsa-mir-21	Essential Hypertension	CONCLUSIONS: Circulating serum levels of miR-21 are increased in elderly patients with EH with LA dilation.
exosome	36560694	hsa-mir-21	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-548c	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-23a	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
exosome	36560694	hsa-mir-26a	Influenza, Human	Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown.
other	36560686	hsa-mir-6741	COVID-19	In sum, we show that circulatory miR5p may serve as a prognostic biomarker effectively predicting mortality risk and LOS of hospitalized COVID-19 patients.
other	36559150	hsa-mir-126	Ischemia	In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia.
other	36558525	hsa-mir-28	Arthritis	OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a.
other	36558525	hsa-mir-199a	Arthritis	OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a.
lncRNA target	36558243	hsa-mir-146a	Inflammation	Our previous studies demonstrated that cerium oxide nanoparticles (CNPs) conjugated with therapeutic microRNA146a (miR146a) could effectively enhance wound healing by targeting the NFkappaB pathway, reducing oxidative stress and inflammation.
other	36556492	hsa-mir-16	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-27a	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-195	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556492	hsa-mir-107	Colorectal Neoplasms	5p, and miR-27a-3p in the colonic mucosa of CRC patients.
other	36556329	hsa-mir-24	COVID-19	Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework.
other	36556329	hsa-mir-148a	COVID-19	Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework.
genetics_knock down_suppress	36556251	hsa-mir-92b	Bone Diseases	Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis.
genetics_knock down_suppress	36556251	hsa-mir-92b	Osteoporosis	Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis.
circulation_biomarker_diagnosis_up	36556238	hsa-mir-1296	Thyroid Cancer, Papillary	Taken together, our findings suggested that circulating exosomal miRNAs, particularly miR
transcription factor target	36555553	hsa-mir-503	Head and Neck Neoplasms	Overall, this study demonstrates that miR-503 suppresses HNC malignancy by inhibiting cell invasion through the Wnt signaling pathway via the WNT3A/MMP molecular axis.
target gene	36555545	hsa-mir-1	Carcinoma, Hepatocellular	Thymoquinone Suppresses Angiogenesis in DEN-Induced Hepatocellular Carcinoma by Targeting miR-1-3p.
other	36555437	hsa-mir-19	Obesity	We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced.
other	36555437	hsa-mir-19a	Obesity	Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity.
other	36555437	hsa-mir-19b	Obesity	Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity.
other	36555437	hsa-mir-19	Obesity, Morbid	We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced.
lncRNA target	36555418	hsa-mir-193b	Muscular Diseases	As a well-known cancer-related miRNA, miR-193b-3p is enriched in skeletal muscle and dysregulated in muscle disease.
transcription factor target	36555301	hsa-mir-200c	Cardiovascular Diseases	In conclusion, downregulated miR-200c-3p in T1DM correlated with diabetic control, VEGF signaling, inflammation, vascular health and targeting VEGF signaling, and may define subclinical CVD.
lncRNA target	36553675	hsa-mir-122b	Oropharyngeal Neoplasms	Our data suggest, for the first time, that ADAM3A and ADAM5 pseudogene-inherited CNV could modulate OPSCC occurrence and prognosis, possibly through the interaction of ADAM5 pseudogene transcript, miR-122b-5p, and ADAM9.
lncRNA target	36553610	hsa-mir-181c	Carcinoma, Hepatocellular	The functional enrichment bioinformatics analyses of miR-181c-5p-downregulated targets in HCC indicated that miR-181c-5p targets were significantly enriched in multiple pathways and biological processes involved in HCC development.
circulation_biomarker_diagnosis_ns	36553586	hsa-mir-375	Prostatic Neoplasms	Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR.
circulation_biomarker_prognosis_up	36553586	hsa-mir-21	Prostatic Neoplasms	The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant.
genetics_overexpression_promote	36553522	hsa-mir-664a	Carcinoma, Hepatocellular	Alcohol Dehydrogenase 4 (ADH4) is a well-known prognostic protein biomarker for predicting the survival outcomes of patients with hepatocellular carcinoma whose expression is regulated by miR-664a-3p, which is upregulated in HCC. In summary, our interaction analyses results predict the significance of the MEG3/miR-664a-3p/ADH4 axis, where MEG3 downregulation results in miR-664a-3p overexpression and the subsequential underexpression of ADH4 in HCC, as a novel axis of interest that demands further validation.
other	36553468	hsa-mir-1268a	Liver Diseases	3p, which might play roles in hepatic fibrosis.
transcription factor target	36552896	hsa-mir-130a	Non-alcoholic Fatty Liver Disease	MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after L. salivarius SNK-6 alleviated liver damage partly via the miR-130a-5p/MBOAT2 signaling pathway.
circulation_biomarker_diagnosis_up	36552891	hsa-mir-19b	Lupus Erythematosus, Systemic	After isolation of peripheral blood mononuclear cells (PBMC) from the SLE group and healthy group and treatment of SLE-derived PBMCs with UC-BSC-derived exosomes, the mRNA levels of corresponding factors in cells under different treatments were determined by RT-PCR, Th17/Treg content was analyzed by FCM (flow cytometry), and the targeted binding of microRNA-19b (miR-19b) to KLF13 was identified by in vitro experiments and bioinformatics analysis. According to the study's findings, SLE patients have dysregulated expression of the genes miR-19b and KLF13, and UC-BSC exosomes could regulate Th17/Treg cell balance and inflammatory factor expression in SLE patients through miR-19b/KLF13.
other	36552749	hsa-mir-143	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-1	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-214	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-125b	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
other	36552749	hsa-mir-200	Heart Failure	A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented.
transcription factor target	36552609	hsa-mir-137	Diabetes Mellitus	This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.
transcription factor target	36552609	hsa-mir-29b	Diabetes Mellitus	This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.
exosome	36551866	hsa-mir-210	Endometriosis	The expression of miR3p was increased in both exosomes and the eutopic endometrium in patients with endometriosis through miRNA sequencing, which could also reduce the proportion of CD80(+) macrophages.
lncRNA target	36551768	hsa-mir-186	Osteosarcoma	Furthermore, circDOCK1 upregulated DNMT3A expression through sponging miR-186 to regulate the progression of OS. CONCLUSIONS: CircDOCK1 promotes OS progression by interacting with miR-186/DNMT3ADNMT3A, representing a novel therapeutic approach.
other	36551704	hsa-mir-335	Adenocarcinoma of Lung	A ceRNA network of KCNQ1OT1/miR5p/DMRT3 was constructed in LUAD.
other	36551202	hsa-mir-126	Non-alcoholic Fatty Liver Disease	NAFLD+LOLA+VitE decreased miR-122, miR-33a and miR-186, and increased miR-126 (p &lt; 0.05, for all) in comparison to NAFLD and NAFLD+VitE.
exosome	36551009	hsa-mir-451	Prostatic Neoplasms	We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis.
exosome	36551009	hsa-mir-21	Prostatic Neoplasms	We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis.
genetics_knock down_promote	36550594	hsa-mir-942	Glioma	LINC01018 knockdown and miR
genetics_overexpression_promote	36550514	hsa-mir-204	Arthritis, Rheumatoid	5p, and its overexpression rescued the repressive impact of miR
other	36550370	hsa-mir-158	Mycoses	Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396.
other	36550370	hsa-mir-156	Mycoses	Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396.
lncRNA target	36550153	hsa-mir-20a	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-375	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-17	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-135b	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550153	hsa-mir-29c	Quadruple Negative Breast Cancer	miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival.
lncRNA target	36550019	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Hsa_circ_0092887 depletion alleviated PTX-resistance in NSCLC cells via modulating the miR
other	36549862	hsa-mir-92	Heart Failure	Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin.
other	36549862	hsa-mir-21	Heart Failure	Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin.
circulation_biomarker_diagnosis_ns	36549775	hsa-mir-377	Acute Coronary Syndrome	The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats.
circulation_biomarker_diagnosis_ns	36549765	hsa-mir-338	Respiratory Distress Syndrome, Newborn	Pearson's correlation analysis evaluated the correlation between serum miR
circulation_biomarker_diagnosis_ns	36549765	hsa-mir-338	Respiratory Distress Syndrome	Pearson's correlation analysis evaluated the correlation between serum miR
other	36549352	hsa-mir-29a	Pulmonary Fibrosis	The current study investigated the ability of THY to modulate oxidative stress, inflammation, miR-29a/TGF-beta expression, and PI3K/phospho-Akt signaling in lung fibrosis.
target gene	36548909	hsa-mir-216b	Stomach Neoplasms	LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis.
exosome	36548450	hsa-mir-124	Cerebral Hemorrhage	In conclusion, ICH-exos delivered lncRNA SND1-IT1 to HMC3 cells, and exosomal lncRNA SND1-IT1 can regulate cell viability and apoptosis to influence HMC3 cell growth via the SND1-IT1/miR3p/MTF1 axis.
lncRNA target	36548440	hsa-mir-1250	Triple Negative Breast Neoplasms	5p acts as tumor suppressor in TNBC cells and its induction by therapeutics might be a novel strategy for the disease treatment.
genetics_overexpression_promote	36546770	hsa-mir-143	Colonic Neoplasms	overexpressing cells restored 5-FU resistance of CRC cells.
other	36546578	hsa-mir-21	Endometriosis	Additionally, a negative correlation of METTL3 was identified with miR5p along with a positive correlation with the WIF1 mRNA in EM tissues.
genetics_overexpression_suppress	36545728	hsa-mir-31	Melanoma	Overexpression of miR
exosome	36545680	hsa-mir-449a	Osteosarcoma	Our findings not only reveal a novel mechanism of miR-449a /CCNB1 in OS but also had laid the groundwork for further investigation and analysis in the field of exosome engineering.
lncRNA target	36545127	hsa-mir-642a	Colonic Neoplasms	Analysis of the potential upstream miRNA of MACC1 showed that miR-642a-5p was downregulated in COAD and was negatively correlated with MACC1 expression. In summary, these findings suggest that MACC1 contributes to COAD progression and immune cell infiltration via the ZFAS1/miR-642a-5p/MACC1 axis.
genetics_overexpression_suppress	36544920	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	COL5A1 overexpression reversed the inhibitory effects of miR
lncRNA target	36544854	hsa-mir-124	Inflammation	An ameliorative action of Pio was demonstrated via decreased CD86 immunoexpression, upregulation of miRNA-124, decreased STAT3 expression and beneficial anti-inflammatory effects. Pio exerted its anti-inflammatory effects via PPARgamma/miRNA-124/STAT3 signaling.
other	36544782	hsa-mir-128	Carcinoma, Non-Small-Cell Lung	3p for participating in LUSC progression.
other	36544695	hsa-mir-23b	Squamous Cell Carcinoma of Head and Neck	Finally, a ceRNA network (SMS/hsa-miR-23b-3p/KTN1-AS1 and VPS9D1-AS axis) was constructed based on the co-expression and survival analyses in HNSC.
target gene	36544654	hsa-mir-200a	Neuroblastoma	Corin is regulated by circ-0012397/miR-200a-3p and inhibits the oxygen-glucose deprivation-induced apoptosis of SHSY5Y neuroblastoma cells.
transcription factor target	36544422	hsa-mir-204	Fetal Growth Retardation	CONCLUSIONS: Inhibiting miR-204 can improve the learning and memory functions of neonatal rats with IUGR, possibly by targeted activation of the BDNF/TrkB signaling pathway.
lncRNA target	36544170	hsa-mir-200a	Osteosarcoma	CONCLUSION: LncEBLN3P is upregulated in osteosarcoma and increases the MTX resistance in osteosarcoma cells through downregulating miR-200a-3p, which in turn promoted the EMT process of osteosarcoma cells by increasing the OGT.
other	36543894	hsa-let-7b	Acute Kidney Injury	Let-7b-5p downregulation may lead to increased renal AKI susceptibility, thus indicating that this miRNA is a potential driver of the MSC treatment response in AKI.
lncRNA target	36543302	hsa-mir-181a	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: In summary, our study demonstrates that LINC01232 expression increases in LUSC tissues and cell lines and promotes LUSC progression by modulating the miR-181a-5p/SMAD2 signaling, providing new potential drug targets for LUSC treatment.
lncRNA target	36542990	hsa-mir-200c	Colorectal Neoplasms	Mechanistically, we proved that circ-ZEB1 could directly bind with miR-200c and functioned as miR-200c sponge to exert its biological functions in CRC cells. In conclusion, circ-ZEB1 could promote CRC cells progression, EMT, and chemoresistance via acting on miR-200c, elucidating a potential therapeutic target to inhibit CRC progression.
other	36542459	hsa-mir-19	Breast Neoplasms	Collectively, these results demonstrated, for the first time, that SFN regulates the miR-19/PTEN axis to exert protective effects against BBP-mediated breast cancer promotion, suggesting a new potential role for SFN (or SFN-rich foods) in phthalate antagonism.
other	36542326	hsa-mir-149	Pituitary Neoplasms	dependent expression of ADAM12 and MMP-14.
circRNA target	36542208	hsa-mir-362	Colorectal Neoplasms	HMGB3 acted as a downstream target for miR
transcription factor target	36541921	hsa-mir-124	Memory Disorders	It is possible that miRNA-124 can be used as a new target for the pathogenesis of memory impairment, including age-associated neurodegenerative diseases such as Alzheimer's disease.
lncRNA target	36541900	hsa-mir-212	Pulmonary Disease, Chronic Obstructive	In conclusion, LINC00599 facilitated CSE-induced cell apoptosis and inflammation response, while inhibiting the cell viability and proliferation in COPD progression via modulating miR
other	36541451	hsa-mir-24	Pneumothorax	In conclusion, the miRNA-24 levels were significantly decreased in children with PSP.
other	36541451	hsa-mir-21	Pneumothorax	In conclusion, the miRNA-24 levels were significantly decreased in children with PSP.
circulation_biomarker_diagnosis_up	36541422	hsa-mir-146b	Pre-Eclampsia	There are a variety of abnormal expression miRNAs in PE, however, the relationship between miR-146b-5p and PE has yet to be fully elucidated.What do the results of this study add? We first found that expression levels of serum miR-146b-5p in the first trimester were significantly higher in PE than in a normal pregnancy group.
genetics_knock down_suppress	36541402	hsa-mir-545	Pancreatic Neoplasms	Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2.
genetics_GWAS	36541377	hsa-mir-4513	Coronary Disease	This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population.
genetics_GWAS	36541377	hsa-mir-146a	Coronary Disease	This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population.
lncRNA target	36541217	hsa-mir-34a	Fatty Liver	Taken together, ATM is a promising therapeutic agent against MAFLD that reduces lipid deposition by suppressing miR-34a-5p and upregulating PPARalpha.
lncRNA target	36541023	hsa-mir-144	Periprosthetic Fractures	3p/RUNX1 pathway may provide a potential target for prevention of PPOL.
other	36540394	hsa-mir-155	COVID-19	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540394	hsa-mir-155	Periodontitis	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540394	hsa-mir-155	Diabetes Mellitus	However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes.
other	36540376	hsa-mir-137	Alzheimer Disease	Furthermore, AD induction was performed by aluminum chloride (Alcl(3)), animals were allocated, and brain hippocampus tissue was isolated for ELISA and qRT-PCR analysis of malondialdehyde (MDA), nuclear factor kappa B (NF-kB), and microRNA-137 (miR-137) coupled with immunohistochemical amyloid-beta (Abeta(1-)42) expression and histopathological finding.
other	36540097	hsa-mir-582	Myocardial Infarction	5p/F2RL2 axis, providing novel biomarkers for MI treatment.
genetics_knock down_promote	36540014	hsa-mir-142	Osteoarthritis	5p reversed the suppressive effects of circ-NT5C2 silencing on the OA progression in vitro, and NAMPT overexpression also attenuated the effects of miR
circulation_biomarker_prognosis_ns	36540006	hsa-mir-146a	Lymphoma, Large B-Cell, Diffuse	This study aims to explore the role of serum miR-146a in predicting the prognosis of DLBCL. CONCLUSION: Our results suggest that the level of serum miR-146a can serve as a potential prognostic biomarker for DLBCL patients.
other	36539984	hsa-mir-21	Lung Neoplasms	Intriguingly, microRNA-21, an early marker of lung cancer, can be detected without being transcribed in advance by an innovative signal amplification strategy using ferritin-mediated aggregation of hydrophilic nitroxide radical monomers as an electrochemical biosensor.
lncRNA target	36539807	hsa-mir-194	Carcinoma, Pancreatic Ductal	5p/SOCS2 axis may be a potential therapeutic target for PDAC patients.
genetics_knock down_promote	36539702	hsa-mir-338	Colorectal Neoplasms	CONCLUSION: This study demonstrated that circ_0039857 knockdown suppressed CRC malignant progression through miR3p/RAB32 axis.
genetics_knock down_promote	36539576	hsa-mir-492	Breast Neoplasms	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-183	Breast Neoplasms	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-183	Precancerous Conditions	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_promote	36539576	hsa-mir-492	Precancerous Conditions	Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk.
genetics_knock down_suppress	36539369	hsa-mir-644a	Esophageal Neoplasms	Besides that, inhibition of miR-644a abolished the promoting action of hsa_circ_0007380 knockdown on esophagus cancer apoptosis and radiosensitivity.
lncRNA target	36539368	hsa-mir-1253	Prostatic Neoplasms	miR-1253 was a downstream molecule of circ-ABCC4, and circ-ABCC4 depletion-mediated anti-cancer impacts in PCa cells were partly counteracted by decreasing miR-1253 abundance. miR-1253 targeted SOX4 mRNA, and miR-1253 blocked PCa cell malignant phenotypes partly by targeting SOX4.
genetics_knock down_promote	36539367	hsa-mir-582	Urinary Bladder Neoplasms	5p targeted KPNA2, and KPNA2 overexpression counteracted the inhibitory impact of miR
lncRNA target	36539365	hsa-mir-338	Carcinoma, Non-Small-Cell Lung	Silencing of circPIM3 suppressed Tax resistance in Tax-resistant NSCLC cells through regulation of the miR3p/TNFAIP8 axis.
genetics_knock down_promote	36539364	hsa-mir-1299	Carcinoma, Non-Small-Cell Lung	MiR-1299 was a target of circ_0058608, and the effects of circ_0058608 knockdown on NSCLC cell progression and taxol resistance were reversed by miR-1299 inhibition.
other	36539363	hsa-mir-451a	Laryngeal Neoplasms	At the same time, miR-451a was found to be the most significantly downregulated miRNA in laryngeal squamous cell carcinoma tissues.
transcription factor target	36539014	hsa-mir-19	Cardiomyopathies	The present study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. CONCLUSIONS: Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways.
lncRNA target	36539001	hsa-mir-142	Breast Neoplasms	This study suggests that GNB2 is an essential target for miR
lncRNA target	36538851	hsa-mir-515	Osteoarthritis	CONCLUSION: FTO alleviated OA in an m6A-dependent manner via the miR5p/TLR4/MyD88/NF-kappaB axis.
other	36538560	hsa-mir-155	Osteoarthritis	As the micro-RNA miR-155 has been found increased in OA chondrocytes, we investigated the effects of high pressure on the expression of the miR-155 host gene Mir155hg.
lncRNA target	36538560	hsa-mir-155	Cartilage Diseases	The chondrocyte progenitor cell line ATDC5 was pressurized under hydrostatic pressure up to 25 MPa and the expression of Mir155hg or the resulting micro-RNAs were measured; pharmacological inhibitors were used to identify the signaling pathways involved in the regulation of Mir155hg.
genetics_GWAS	36538546	hsa-mir-20a	Polycystic Kidney Diseases	We compared the relative expression profile of miR-20a, -192, -365, -15b-5p, and 5p from plasma and serum samples of nine domestic cats with PKD1 mutation, detected by polymerase chain reaction (PCR), and a control group (n = 10).
lncRNA target	36538280	hsa-mir-576	Endometrial Neoplasms	5p promoted proliferation and metastasis capacity of EC cells by inhibiting ZBTB4 expression.
circRNA target	36538242	hsa-mir-135a	Urinary Bladder Neoplasms	Mechanically, circSTK39 could sponge with miR-135a-5p, thus inhibiting NR3C2-mediated EMT processes in the BCa progression. In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa.
transcription factor target	36538194	hsa-mir-155	Meningioma	The findings suggest that miR5p play an important role in the pathogenesis of meningioma and may represent potential therapeutic targets for its anti-PD-L1 immunotherapy.
circulation_biomarker_diagnosis_ns	36538076	hsa-mir-138	Acute Lung Injury	Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR
circulation_biomarker_diagnosis_ns	36538076	hsa-mir-138	Sepsis	Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR
lncRNA target	36537157	hsa-mir-9	Acute Lung Injury	5 p in ALI via regulating macrophage polarization.
other	36537124	hsa-mir-4640	Osteoarthritis	5p/NOTCH2 axis stimulates the Notch pathway to promote the transcription of inflammatory cytokines (IL33, IL17F and IL6), consequently facilitating OA progression in murine chondrocytes.
circulation_biomarker_prognosis_ns	36537076	hsa-mir-3201	Carcinoma, Hepatocellular	Conclusions: Blood miR-3201 could be used as a prognostic biomarker for curative therapy response and OS in HCC.
transcription factor target	36536941	hsa-mir-186	Atherosclerosis	CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1.
transcription factor target	36536941	hsa-mir-186	Myocardial Infarction, Acute	CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1.
other	36536870	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: miRNA-145 is significantly altered in OSCC in our patient population and its reduced values carry a poor prognosis.
other	36536516	hsa-mir-28	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: PUM2 plays as a novel oncogenic RBP in T-ALL by competitively binding to RBM5 mRNA with miR5p.
genetics_knock down_promote	36536496	hsa-mir-1179	Pancreatic Carcinoma	Moreover, the miR-1179 inhibitor reversed the regulation of circ_0000284 knockdown on PC cell progression.
other	36536183	hsa-mir-122	Celiac Disease	3p was significantly increased in CD patients relative to control subjects (p = 0.049).
transcription factor target	36536183	hsa-mir-197	Celiac Disease	Increased expression of miR3p with a final protective effect on Occludin expression can be further studied as a complement therapeutic target for Celiac disease.
transcription factor target	36535956	hsa-mir-126	Carcinoma, Hepatocellular	5p, one of the tumor-suppressive genes commonly decreased in HCC, was found negatively expressed and correlated with SNRPF1, and a specific region of SNRPF1 transcript is directly binding to miR
other	36535942	hsa-mir-378	Pancreatic Carcinoma	The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival.
other	36535942	hsa-mir-378a	Pancreatic Carcinoma	The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival.
circRNA target	36535407	hsa-mir-495	Leukemia	3p expression is important in the malignant phenotype of CML and TKI resistance mechanisms and could be a useful biomarker and a potential therapeutic target to eradicate CML.
target gene	36535369	hsa-mir-486	Immunoglobulin G4-Related Disease	Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
circulation_biomarker_diagnosis_ns	36535313	hsa-mir-133a	Diabetes Mellitus, Type 2	So, this study examined the effects of eight weeks combination of 250 mg of UA per day per kilogram of body weight of rat as well as resistance/endurance training on miR-133a expression across serum, bone marrow, skeletal muscle, and Connexin 43 (Cx43)-Runt-related transcription factor 2 (Runx2) signaling axis in high-fat diet and low-dose streptozotocin-induced T2D (here, HFD/STZ-induced T2D). In conclusion, only eight weeks of resistance-type exercise could affect miR-133a profile in muscles and osteoblast differentiation biomarker RUNX2 in aged T2D model of rats.
other	36535134	hsa-mir-124	Brain Ischemia	3p and Nrep level in the MCAO model were found to be lower in the model predicted by bioinformatics than in the sham-operated group.
genetics_overexpression_promote	36535076	hsa-mir-181b	Colorectal Neoplasms	To elucidate the influence of CAFs-derived exosome miR-181b-3p on CRC, we overexpressed and knocked down the miR-181b-3p expression in CAFs, respectively.
exosome	36535010	hsa-mir-485	Pancreatic Carcinoma	3p by exosomes or some other vehicle might be a novel approach for PC treatment.
circulation_biomarker_diagnosis_up	36534156	hsa-mir-199a	Hirschsprung Disease	Plasma exosomal miR-199a-3p, a diagnostic marker, is crucial for the development of HSCR.
circulation_biomarker_prognosis_ns	36533956	hsa-mir-192	Esophageal Squamous Cell Carcinoma	Plasma miR5p could be used as a predictor of response to chemotherapy and prognosis in EC patients.
lncRNA target	36533778	hsa-mir-19a	Pre-Eclampsia	Our results elucidated that circ_0004904 reduced proliferation and cell motility of trophoblast cells via the miR-19a-3p-mediated GADD45A level elevation, indicating the involvement of circ_0004904/miR-19a-3p/GADD45A in PE progression.
target gene	36533720	hsa-mir-136	Esophageal Squamous Cell Carcinoma	CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma.
genetics_overexpression_promote	36533591	hsa-mir-125b-2	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
genetics_overexpression_promote	36533591	hsa-mir-214	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
genetics_overexpression_promote	36533591	hsa-mir-326	Hypertension, Pulmonary	3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs.
lncRNA target	36531954	hsa-mir-155	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
lncRNA target	36531954	hsa-mir-185	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
lncRNA target	36531954	hsa-mir-664a	Intervertebral Disc Degeneration	We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR
circulation_biomarker_prognosis_ns	36531335	hsa-mir-340	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis.
circulation_biomarker_prognosis_ns	36531335	hsa-mir-450b	Carcinoma, Non-Small-Cell Lung	CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis.
genetics_overexpression_suppress	36531016	hsa-mir-182	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
genetics_overexpression_suppress	36531016	hsa-mir-21	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
genetics_overexpression_suppress	36531016	hsa-mir-146b	Mouth Neoplasms	5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354).
circulation_biomarker_diagnosis_up	36530488	hsa-mir-27a	Liver Neoplasms	The results showed that miR-27a-3p is downregulated in blood, cell lines, and tissues of HCC patients compared to normal controls.
target gene	36530029	hsa-mir-29a	Liver Neoplasms	miR-29a-5p regulates the malignant biological process of liver cancer cells through ARID2 regulation of EMT.
lncRNA target	36530027	hsa-mir-7	Femur Head Necrosis	OBJECTIVES: To investigate whether circHIPK3 promotes bone microvascular activity and angiogenesis by targeting miR-7 and Kruppel-like factor 4 (KLF4)/vascular endothelial growth factor (VEGF) signaling in ONFH.
genetics_overexpression_suppress	36529892	hsa-mir-105	Carcinoma, Non-Small-Cell Lung	Overexpression of FAM138B can inhibit the expression level of miR
genetics_overexpression_promote	36529430	hsa-mir-138	Glioma	5p repressed the glioma malignant phenotype and MeCP2 overexpression reversed the inhibitory effect of miR
lncRNA target	36529281	hsa-mir-133a	Bloom Syndrome	SIGNIFICANCE: These findings suggest that MALAT1 positively regulates RhoA protein expression by inhibiting miR-133a-3p in BSM cells, and that its upregulation causes the RhoA upregulation, resulting in an augmented BSM contractility.
other	36529281	hsa-mir-133a	Asthma	In BSMs of the murine asthma model, upregulations of Malat1 and RhoA protein were observed concomitantly with downregulation of miR-133a-3p.
tissue_expression_ns	36529101	hsa-mir-34a	Anovulation	In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased.
tissue_expression_ns	36529101	hsa-mir-34a	Intestinal Atresia	In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased.
lncRNA target	36529069	hsa-mir-193a	Multiple Sclerosis	Therefore, miR-193a and its associated targets could serve potential prognostic, diagnostic, and therapeutic efficacy in MS patients.
genetics_knock down_promote	36528986	hsa-mir-136	Carcinoma, Hepatocellular	5p re-expression inhibited HCC cell growth and metastasis, which was abated by KIAA1522 overexpression.
lncRNA target	36528556	hsa-mir-520c	Squamous Cell Carcinoma of Head and Neck	The expression of HOXA-AS2 was found to be negatively associated with miR-520c-3p in OSCC tissues. CONCLUSION: HOXA-AS2 served an oncogene and promoted OSCC progression via the miR-520c-3p/SNX5 axis.
lncRNA target	36527891	hsa-mir-483	Leukemia, Monocytic, Acute	CONCLUSION: LncRNA NR2F1-AS1 affects the sensitivity of THP-1 cells to azacitidine resistance by regulating the miR3p/IGF1 axis, which may be a potential target for the treatment of acute monocytic leukemia.
lncRNA target	36527878	hsa-mir-140	Osteoarthritis, Knee	5p protects CPCs from fate changes via inhibiting Jagged1/Notch signaling in knee OA, providing attractive targets for OA therapeutics.
other	36527420	hsa-mir-183	Amyotrophic Lateral Sclerosis	5p and provides a molecular link between aberrant RNA processing and protein degradation, two major pillars in ALS pathogenesis.
lncRNA target	36527387	hsa-mir-139	Diabetes Mellitus	5p/HOXA9 might be an important therapeutic target in treating diabetic BMSCs and diabetic complications in the future.
other	36526091	hsa-mir-26b	Diabetic Retinopathy	3p, which was not observed in the other models.
other	36526091	hsa-mir-122	Diabetic Retinopathy	3p, which was not observed in the other models.
lncRNA target	36525235	hsa-mir-424	Carcinoma, Endometrioid	Rescue experiments further supported that lncRNA E27 inhibited proliferation, migration, invasion, and promoted apoptosis of endometrial cancer through miR-424/E2F6/E2F7 signaling axis. Conclusively, our findings revealed the role of lncRNA E27 in regulating the miR-424/E2F6/E2F7 signaling axis during EC progression, opening up new strategies for the treatment of endometrial cancer.
other	36524862	hsa-mir-144	Glaucoma	CONCLUSION: Circ_0047835 might contribute to fibrosis progression after glaucoma surgery by regulating the miR3p/SP1 axis.
epigenetics	36524545	hsa-mir-1258	Carcinoma, Hepatocellular	Systemic analysis and experimentally validation identified a ceRNA network (PVT1/miR-1258/DUSP13 axis) characterized by lipid regulatory potential, immune properties, and abnormal methylation states in patients with HCC and MVI. Furthermore, miR-1258 was an independent predictor for MVI in patients with HCC.
circRNA target	36524450	hsa-mir-199b	Carcinoma, Hepatocellular	MiR-199b-5p suppressed HCC progression by inhibiting STRN expression.
other	36524359	hsa-mir-3065	Carcinoma, Hepatocellular	ZFPM2AS1 regulates XRCC4 by sponging miR30655p to promote GS and HCC progression.
epigenetics	36524356	hsa-mir-378a	IMAGe syndrome	The SUFU gene promoter remained unmethylated in all tissue samples, while miR2143p and miR378a5p were downregulated in IUGR.
circulation_biomarker_diagnosis_ns	36524216	hsa-mir-193a	Keloid	The hsa_circ_0020792 and miR-193a-5p levels in keloid patient-Exo and healthy control-Exo, as well as in keloid fibroblasts and normal skin fibroblasts (NFs) were evaluated by RT-qPCR. CONCLUSION: Collectively, keloid patient plasma-derived exosomal hsa_circ_0020792 could promote the proliferation, migration, and fibrogenesis of NFs via modulating miR-193a-5p and activating TGF-beta1/Smad2/3 signaling.
exosome	36524211	hsa-mir-503	Glioma	Herein, the aim of the current investigation was to explore the functional role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-503 in glioma.
lncRNA target	36524095	hsa-mir-193b	Cardiomegaly	Here, the mechanism of action of the lncRNA terminal differentiation-induced non-coding RNA (TINCR), miR-193b-3p, and RAR-related orphan receptor A (RORA) mRNA was analyzed in an angiotensin (Ang) II-induced H9C2 cardiomyocyte hypertrophy model treated with QYDP. CONCLUSIONS: Administration of QYDP improves Ang II-induced H9C2 cardiomyocyte hypertrophy and increase cell proliferation rate through the TINCR/miR-193b-3p/RORA axis.
lncRNA target	36523634	hsa-mir-199a	Respiratory Distress Syndrome	The agomirs or antagomirs of MiR-199a-3p were injected into the caudal vein to figure out whether MiR-199a-3p could influence ARDS inflammation and lung injury, whereas the mimics or inhibitors of MiR-199a-3p, siRNA of Rab8a, or PAK4 inhibitor were transfected or applied to RAW264.7 cells to evaluate the mechanism of SAP release.
other	36523600	hsa-mir-92b	Polycystic Ovary Syndrome	BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction.
other	36523600	hsa-mir-20b	Polycystic Ovary Syndrome	BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction.
other	36523511	hsa-mir-149	Carcinoma, Renal Cell	We also identified the lncRNA UBA6-AS1/miR5p/MMP9 regulatory axis for the progression of ccRCC.
genetics_overexpression_suppress	36523479	hsa-mir-4472	Breast Neoplasms	miR-4472 levels were reduced, and repulsive guidance molecule A (RGMA) mRNA or protein levels were increased after overexpression of RP11-551L14.4 in the breast cancer cells.
circulation_biomarker_diagnosis_ns	36523365	hsa-mir-126	Myocardial Infarction, Acute	CONCLUSION: Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events.
other	36523292	hsa-mir-1	Glioma	The present study was to analyze the mechanism of microRNA (miR)-1 in regulating the proliferation and invasion of glioma cells.
genetics_overexpression_promote	36523183	hsa-mir-362	Osteoarthritis	Additionally, overexpressed miR
genetics_knock down_promote	36523170	hsa-mir-760	Lung Neoplasms	RAB3D was a target of miR-760, and its knockdown reversed the promotion effect of miR-760 inhibitor on the progression of curcumin-treated LC cells.
transcription factor target	36523152	hsa-mir-182	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: CXCR7 protects against cerebral I/R injury, possibly via the miR-182/TCF7L2/Hippo pathway.
circulation_biomarker_diagnosis_ns	36523143	hsa-mir-197	Atherosclerosis	3p was decreased in the serum of AS patients compared to healthy donors.
circulation_biomarker_diagnosis_up	36522766	hsa-mir-149	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer.
circulation_biomarker_diagnosis_up	36522766	hsa-mir-4769	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer.
exosome	36522730	hsa-mir-21	Colonic Neoplasms	CONCLUSIONS: Our results implicated a reciprocal communication between colon cancer cells and Schwan cells that promoted the proliferation and metastasis of colon cancer, and identified NGF and exosomal miR
other	36522710	hsa-mir-126	Pulmonary Disease, Chronic Obstructive	Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH.
other	36522710	hsa-mir-126	Hypertension, Pulmonary	Since CS decreases miR126 in microvascular lung endothelial cells, we set out to characterize the remodeling by pulmonary vascular size in COPD-PH and its relationship with miR126 in COPD and COPD-PH lungs. Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH.
lncRNA target	36522683	hsa-mir-449b	Esophageal Squamous Cell Carcinoma	CONCLUSIONS: IGF2BP2 mediated circRUNX1 functions as an oncogenic factor to facilitate ESCC progression through the miR-449b-5p/FOXP3 axis, implying that circRUNX1 has the potential to be a promising diagnostic marker and therapeutic target for ESCC patients.
lncRNA target	36522638	hsa-mir-26a	Parvoviridae Infections	parvum as well as treated with miR-26a-mimic, miR-30a-mimic, miR-26a-mimic or miR-30a-inhibitor post C.
genetics_overexpression_suppress	36522613	hsa-mir-495	Melanoma	3p, and CREB1 overexpression enhanced melanoma cell viability by inhibiting miR
genetics_overexpression_promote	36522479	hsa-mir-181b	Breast Neoplasms	Overexpression of miR-181b-5p downregulated p53/p21 levels and inhibited doxorubicin-induced G1 arrest and senescence by suppressing BCLAF1 expression in vitro.
lncRNA target	36522211	hsa-mir-18b	Pulpitis	DUXAP8 upregulation and miR-18b-5p downregulation were found in pulpitis. CONCLUSIONS: Results demonstrated that LPS-induced cell injury in pulpitis was promoted by DUXAP8 through mediating miR-18b-5p/HIF3A axis.
exosome	36521318	hsa-mir-543	adhesions of uterus	Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions.
exosome	36521318	hsa-mir-543	Uterine Diseases	Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions. DISCUSSION: Collectively, UCMSCs-derived exosomal miR-543 was able to prevent endometrial fibrosis both in vitro and in vivo via downregulating N-cadherin.
genetics_knock down_suppress	36520963	hsa-mir-1	Nasopharyngeal Carcinoma	Knockdown of lncRNA SNHG16 attenuates radioresistance of nasopharyngeal carcinoma cells by miR
exosome	36520505	hsa-mir-143	Periodontitis	In conclusion, these results demonstrate that inflammatory PDLSCs facilitate M1 macrophage polarization through the exosomal miR
target gene	36520299	hsa-mir-2053	Colitis, Ulcerative	Collectively, rs6214 increased UC susceptibility and suppresses IGF-1 expression by enhancing miR-2053 binding.
lncRNA target	36520091	hsa-mir-335	Bone Diseases	In conclusion, melatonin facilitates osteogenesis in bone defect healing by enhancing miR5p expression and inhibiting the TNFalpha/NF-kappaB pathway.
circRNA target	36519785	hsa-mir-363	Prostatic Neoplasms	We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management.
circRNA target	36519785	hsa-mir-708	Prostatic Neoplasms	We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management.
lncRNA target	36519522	hsa-mir-874	Colorectal Neoplasms	CONCLUSION: Circ-CCS expedited CRC through miR
circulation_biomarker_diagnosis_up	36519433	hsa-mir-155	Pre-Eclampsia	RESULTS: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels.
genetics_knock down_promote	36519409	hsa-mir-124	Gastric   Cancer	3p or increasing ZNF655 could counteract the effects of LINC01210 knockdown on GC cell development.
other	36519254	hsa-mir-519a	Carcinoma, Hepatocellular	CONCLUSION: These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR-519a-5p/ARHGAP29 axis in HCC development.
circulation_biomarker_diagnosis_ns	36519116	hsa-mir-93	Tuberculosis	RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB.
circulation_biomarker_diagnosis_ns	36519116	hsa-mir-16	Tuberculosis	RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB.
genetics_GWAS	36518850	hsa-mir-122	Carcinoma, Hepatocellular	The aim of this study was to evaluate phenotypic and genetic heterogeneity of circulating epithelial cells (CECs) based on asialoglycoprotein receptor 1 (ASGR1) and miR
genetics_knock down_promote	36518817	hsa-mir-101	Pulmonary Disease, Chronic Obstructive	3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell BACKGROUND: Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function.
circulation_biomarker_diagnosis_ns	36518749	hsa-mir-138	Scleroderma, Systemic	Accordingly, the gene expression of miR-138 was assessed to find any alterations in the whole blood of the SSc patients.
lncRNA target	36518289	hsa-mir-491	Colorectal Neoplasms	3p expression promotes CRC progression through regulating uMtCK.
circulation_biomarker_diagnosis_ns	36517751	hsa-mir-184	Cardiotoxicity	We also found that distribution of particular miRNAs between of plasma and EVs (proportion between compartments) e.g., miR-184 in ALL, is altered, suggesting changes within secretory and miRNA sorting mechanisms.
circulation_biomarker_diagnosis_ns	36517751	hsa-mir-144	Cardiotoxicity	Moreover, vesicular miR3p correlates with the highest number of echocardiographic parameters and is differentially expressed in the circulation of patients with dilated cardiomyopathy.
genetics_knock down_promote	36517015	hsa-mir-423	Cardiomegaly	5p knockdown exerts its protective effects on Ang II-induced cardiomyocyte hypertrophy in HCMs via modulating SUPT6H expression.
lncRNA target	36515797	hsa-mir-671	late onset Parkinson's disease	UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD.
genetics_knock down_suppress	36515797	hsa-mir-671	Inflammation	KPNA4 overexpression offset the inhibitory influence of miR
lncRNA target	36515797	hsa-mir-671	Aicardi-Goutieres syndrome 5	UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD.
exosome	36515680	hsa-mir-195a	Acute Kidney Injury	Furthermore, in vitro inhibition of miR-195a-5p alleviated the effect of Exos(AKI) induced mitochondrial dysfunction and cell injury.
other	36515567	hsa-mir-382	Squamous Cell Carcinoma of Head and Neck	Our data demonstrate that circ_0000052 is oncogenic, and the circ_0000052/miR3p/PD-L1 axis is critical in HNSCC progression.
genetics_overexpression_suppress	36515277	hsa-mir-1290	Stomach Neoplasms	MiR-1290 was predicted as a target of circ_0026344 and miR-1290 overexpression attenuated the anti-tumor effect of circ_0026344 on GC cells. CONCLUSION: In conclusion, circ_0026344 inhibited GC cell proliferation via the miR-1290/FBP2 axis, which might provide a new therapeutic target for GC patients.
exosome	36514348	hsa-mir-222	Pre-Eclampsia	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways.
exosome	36514348	hsa-mir-222	Hypertension, Pregnancy-Induced	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways.
exosome	36514348	hsa-mir-155	Pre-Eclampsia	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE).
exosome	36514348	hsa-mir-155	Hypertension, Pregnancy-Induced	This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE).
other	36514216	hsa-mir-486	Pulmonary Disease, Chronic Obstructive	5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD.
genetics_overexpression_promote	36514078	hsa-mir-709	Spinal Cord Injuries	Moreover, experiments confirmed that Treg cells targeted the NKAP via exosomal miR-709 to reduce microglia pyroptosis and promote motor function recovery after SCI. More importantly, The miR-709 overexpressed exosomes we constructed significantly reduced the inflammatory response and improved motor recovery after spinal cord injury.
other	36513954	hsa-mir-214	Breast Neoplasms	5p/ROCK1 pathway, which might provide a new perspective to investigate the development process of BC.
target gene	36513872	hsa-mir-196a	Stomach Neoplasms	miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2.
genetics_overexpression_promote	36513585	hsa-mir-95	Triple Negative Breast Neoplasms	CONCLUSION: Overexpression of circ_0001777 decreased proliferation, migration, and invasion of TNBC cells by regulating the miR
circulation_biomarker_diagnosis_ns	36513264	hsa-mir-21	renal fibrosis	RESULTS: A positive correlation was found between plasma miR-21 levels and RF scores of rats after UUO surgery at Days 3, 7, 14 and 21.
other	36513253	hsa-mir-144	Non-alcoholic Fatty Liver Disease	5p was reduced in HFD-managed models and patients with NAFLD.
transcription factor target	36513242	hsa-mir-429	Kidney Diseases	These findings suggest that endosulfan can lead to kidney cell injury by modulating ACE2 through up-regulating miR-429, providing new evidence for the pathogenesis of CKDu.
genetics_overexpression_suppress	36512648	hsa-mir-655	Thyroid Cancer, Papillary	Overexpression of miR
lncRNA target	36512502	hsa-mir-122	Hepatitis C	Our study identifies PLK1-ELAVL1/HuR-miR-122 signaling as a regulatory axis that is critical for HCV proliferation, and suggests that a therapeutic approach targeting this host cell signaling pathway could be useful for treating HCV and HCV-associated diseases.
lncRNA target	36512324	hsa-mir-532	Carcinoma, Ovarian Epithelial	Furthermore, circATP2B4 induced macrophage M2 polarization by regulating the miR3p/SREBF1/PI3Kalpha/AKT axis, thereby leading to immunosuppression and ovarian cancer metastasis.
other	36511578	hsa-mir-155	Lung Neoplasms	In the second group, miR5p allows to predict lung cancers and colon cancers.
other	36511578	hsa-mir-155	Colonic Neoplasms	In the second group, miR5p allows to predict lung cancers and colon cancers.
other	36511422	hsa-mir-590	Myocardial Reperfusion Injury	3p regulates the TLR4/MyD88/NF-kappaB pathway by interacting with HMGB1 to protect against OGD/R-induced I/R injury.
other	36511396	hsa-mir-7	Alzheimer Disease	This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia.
circulation_biomarker_diagnosis_up	36510992	hsa-mir-1246	Colorectal Neoplasms	CONCLUSION: We confirmed the capability of circulating serum miR-1229 and miR-1246 as novel diagnostic biomarkers for CRC.
transcription factor target	36510830	hsa-mir-216b	Angelman Syndrome	The function of miR-216b-5p in AS remains unknown. miR-216b-5p alleviates the dysfunction of VSMCs and HUVECs caused by ox-LDL via repressing IGF2, and exerts protective functions to block the development of AS.
lncRNA target	36510610	hsa-mir-2116	Retinal Diseases	CONCLUSION: Rg1 inhibits HG-induced proliferation, migration, angiogenesis, and VEGF expression in retinal endothelial cells through the lncRNA SNG7/miR5p/SIRT3 axis.
genetics_overexpression_promote	36510495	hsa-mir-1	Lupus Erythematosus, Systemic	5p was downregulated and negatively correlated with the overexpression of SLC15A4 in PBMCs of SLE patients.
lncRNA target	36510038	hsa-mir-29c	Pancreatic Carcinoma	RESULTS: Through differential analysis, five pancreatic cancer-related miRNAs (hsa-miR-29c, hsa-miR-107, hsa-miR
lncRNA target	36509232	hsa-mir-101	Osteosarcoma	In addition, our study proved that TYMSOS promotes the malignancy of OS via elevating NETO2 expression as miR
other	36508822	hsa-mir-146b	Immune System Diseases	The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation.
other	36508822	hsa-mir-146b	Pneumonia	The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation.
genetics_knock down_suppress	36508789	hsa-mir-125a	Pulmonary Fibrosis	MiR-125a-5p anta-miR treatment contributes to the maintenance of Th1/Th2 balance during the progression of pulmonary fibrosis. Our findings indicated that knockdown miR-125a-5p could regulate T lymphocyte subsets and significantly reduce pulmonary fibrosis by targeting TRAF6.
lncRNA target	36508480	hsa-mir-199a	High Grade Ovarian Neoplasms	After treatment with CGA, cells derived from ovarian cancer cells were deregulated partially via the miR199a5p/DDR1 axis, significantly affecting tumour suppression. DDR1 has been identified as a direct target of miR199a5p in these ovarian cancer cells.
genetics_overexpression_promote	36508388	hsa-mir-1298	Uterine Cervical Neoplasms	While silencing of ONECUT2 could suppress the proliferation of cervical cancer cells, its overexpression could nullify the tumor-suppressive effects of miR
lncRNA target	36508036	hsa-mir-370	Endometriosis	CONCLUSION: IGF2-AS promotes endometriotic cell growth via regulating IGF2/miR3p axis and further activating PI3K/AKT/mTOR signaling pathway.
exosome	36506936	hsa-mir-425	Breast Neoplasms	Transfection of exosomes is obtained from BC cells, and miR
circulation_biomarker_diagnosis_up	36506422	hsa-mir-200a	Depressive Disorder, Major	Relative serum levels of miR-30a, miR-30e, and miR-200a, normalized to U6, were measured by quantitative real-time PCR in MDD inpatients with (MDD/SI, N = 19) and without (MDD, N = 31) acute suicide risk.
lncRNA target	36506327	hsa-mir-17	Varicose Veins	Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1.
lncRNA target	36506327	hsa-mir-21	Varicose Veins	Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1.
transcription factor target	36506063	hsa-mir-26b	Diabetes Mellitus, Type 1	Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.
transcription factor target	36506063	hsa-mir-21	Diabetes Mellitus, Type 1	Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation.
transcription factor target	36506055	hsa-mir-92b	Alstrom Syndrome	Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups.
transcription factor target	36506055	hsa-mir-92b	Bardet-Biedl Syndrome 11	Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups.
circulation_biomarker_diagnosis_up	36505330	hsa-mir-355	Mucocutaneous Lymph Node Syndrome	CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease.
circulation_biomarker_diagnosis_up	36505330	hsa-mir-2911	Mucocutaneous Lymph Node Syndrome	CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease.
circulation_biomarker_prognosis_ns	36505313	hsa-mir-127	Sepsis	The areas under the ROC curve (AUC) of serum miR-127, SOFA score, and APACHE II score for predicting prognosis of sepsis patients were 0.748 (0.674-0.823), 0.810 (0.742-0.878) and 0.864 (0.811-0.916), respectively.
target gene	36505312	hsa-mir-370	Lung Neoplasms	miR-370 impacts the biological behavior of lung cancer cells by targeting the SMAD1 signaling pathway.
genetics_knock down_promote	36505286	hsa-mir-216b	Colorectal Neoplasms	miR-216b overexpression suppressed tumor growth, metastasis and expressions of CPEB4, CD206 and IL-10 in CRC xenograft models.
lncRNA target	36505084	hsa-mir-31	Leukemia	HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs.
lncRNA target	36505084	hsa-mir-193	Leukemia	HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs.
circulation_biomarker_diagnosis_up	36504565	hsa-mir-18a	Stomach Neoplasms	CONCLUSION: A panel of circulating miR18a/21/125b could be suggested as a potential biomarker for the early detection of GC.
lncRNA target	36504472	hsa-mir-146a	Diabetes Mellitus	Furthermore, the downregulation of mir146a, as an inflammatory microRNA interacting with TLR4, showed another pathway, through which tropisetron improved diabetes-induced testicular injuries.
lncRNA target	36504384	hsa-mir-371a	Necrosis	BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT.
lncRNA target	36504384	hsa-mir-371a	Teratoma	BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT.
exosome	36504133	hsa-mir-21	Hyperglycemia	This study aimed to investigate the effects of AS-IV-mediated EPCs exosomal miR-21 (EPC-exos-miR-21) on high glucose (HG) damaged endothelial cells.
circulation_biomarker_diagnosis_up	36504065	hsa-mir-342	Arthritis, Rheumatoid	3p in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA) and its effect on inflammatory response and migration of synovial fibroblasts in RA (RA-FLS).
genetics_knock down_suppress	36504056	hsa-mir-4772	Ovarian Neoplasms	Survival analysis was carried out to identify the survival-related hub genes, and the results were validated using the data of 399 patients with ovarian cancer from GEO database and the sequencing results of SKOV3 cells transfected with miR-4772 mimics or inhibitor.
genetics_overexpression_promote	36504050	hsa-mir-607	Carcinoma, Hepatocellular	Overexpression of miR-607 inhibits HCC growth and metastasis possibly by down- regulating TRPC5, which causes Akt signaling inactivation.
other	36503407	hsa-mir-520h	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-374a	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-520h	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-628	Pregnancy Complications	5p.
other	36503407	hsa-mir-191	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-191	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-125b	Pregnancy Complications	5p.
other	36503407	hsa-mir-518b	Pregnancy Complications	5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Premature Birth	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Hypertension, Pregnancy-Induced	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
other	36503407	hsa-mir-518b	Pre-Eclampsia	Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia.
lncRNA target	36503346	hsa-mir-8082	Osteoarthritis	In our study, patients with OA showed downregulation of NAV2-AS5, upregulation of miR-8082, and downregulation of TNFAIP3 interacting protein 2 (TNIP2). In conclusion, these findings indicate that NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in OA, which provides a new theoretical basis for OA therapy.
lncRNA target	36503162	hsa-mir-581	Prostatic Neoplasms	In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/beta-catenin pathways.
tissue_expression_up	36502883	hsa-mir-146a	Triple Negative Breast Neoplasms	The analysis of the external validation cohorts corroborated the unfavorable nature of miR-146a repression regarding patients&#x27; survival and, strikingly, unveiled the ability of miR-146a to predict TNBC metastasis.
target gene	36502446	hsa-mir-27b	Lymphoma, Large B-Cell, Diffuse	miR-27b can inhibit the proliferation and invasiveness of DLBCL cells and promote the apoptosis of the cells by targeting MET/PI3K/AKT pathway.
transcription factor target	36499744	hsa-mir-122	Fibrosis, Renal	5p inhibitor suppressed renal fibrosis and downregulated COL1A2 and FN1.
genetics_overexpression_suppress	36499676	hsa-mir-145	Carcinoma, Non-Small-Cell Lung	5p by BMI1 overexpression could lead to the enhanced expression of Sp1 to induce the EMT process in pemetrexed-resistant NSCLC cells.
other	36499626	hsa-mir-200c	Ovarian Neoplasms	Moreover, miR-200c increased the sensitivity of ovarian cancer cells to cisplatin treatment by regulating mortalin levels. The combination of cisplatin and miR-200c significantly enhanced the therapeutic effects on ovarian cancer in vivo, suggesting that miR-200c may serve as a potential therapeutic agent for ovarian cancer.
lncRNA target	36499626	hsa-mir-200b	Ovarian Neoplasms	In this study, microRNA (miR)-200b/c downregulated mortalin expression and inhibited the proliferation and migration of the paired cisplatin-sensitive (A2780S) and cisplatin-resistant (A2780CP) epithelial ovarian cancer cell lines.
other	36499586	hsa-mir-122	Colonic Neoplasms	In conclusions, the study has explored the role of miR-122 in CRC and has identified a closely related group of genes influencing the prognosis of CRC in multiple ways.
other	36499552	hsa-mir-342	Heart Failure	3p) revealed pathways related to HF pathogenesis.
other	36499552	hsa-mir-125a	Heart Failure	3p) revealed pathways related to HF pathogenesis.
other	36499552	hsa-let-7a	Heart Failure	3p) revealed pathways related to HF pathogenesis.
transcription factor target	36499501	hsa-mir-186	Urinary Bladder Neoplasms	5p were confirmed as interfering with the stability of the mRNAs of DAP10, CD96, and the perforin gene in NK cells and may be potential targets used in the therapy for BC.
other	36499397	hsa-mir-200c	FG syndrome	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
other	36499397	hsa-mir-200c	Hematologic Diseases	We investigated the expression of miR-200c in urine from patients with different renal diseases as a potential candidate involved in podocytopathies.
other	36499397	hsa-mir-200c	Glomerulonephritis, Membranous	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
other	36499397	hsa-mir-200c	Nephrosis, Lipoid	miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes.
epigenetics	36499350	hsa-mir-124-2	Acquired Immunodeficiency Syndrome	Our bisulfite-converted genomic DNA sequencing also revealed significant promoter DNA methylation in the pri-miR
genetics_overexpression_suppress	36499299	hsa-mir-4732	Premature Birth	Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR5p was significantly overexpressed.
other	36499299	hsa-mir-125a	Premature Birth	Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95% CI: 0.814-0.972; p < 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk.
other	36499183	hsa-mir-18a	Prostatic Neoplasms	In conclusion, deregulation of the miR-18a-5p/P4HB network can contribute to the developmental origins of prostate cancer in maternally malnourished offspring, highlighting the need for improving maternal healthcare during critical windows of vulnerability early in life.
other	36499129	hsa-mir-21	Breast Neoplasms	miR-21 is upregulated in breast cancer that has been linked to drug resistance and carcinogenic processes.
other	36499093	hsa-mir-26a	Extramedullary Multiple Myeloma	Further, miR-26a-5p and miR-30e-5p were found to be significantly down-regulated in EMD compared to MM.
other	36499048	hsa-mir-222	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-140	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-15a	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-124	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499048	hsa-mir-106b	Frontotemporal Dementia	3p (FC: 2.1, p = 0.01, FDR = 0.893).
other	36499023	hsa-mir-369	Diabetes Mellitus, Type 2	3p).
other	36499023	hsa-mir-369	Hypoglycemia	3p).
genetics_overexpression_promote	36498905	hsa-mir-29c	Pulmonary Fibrosis	miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-.
genetics_overexpression_promote	36498905	hsa-mir-29c	Antisynthetase syndrome	miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-.
circRNA target	36497344	hsa-mir-934	Breast Neoplasms	Altogether, these findings reveal that circRNF10 functions as a novel anti-oncogene in BC via sponging miR-934 and suppressing the PI3K/Akt/MICA pathway.
exosome	36497115	hsa-mir-20a	Carcinoma, Hepatocellular	In summary, LIMA1 is a tumour suppressor that inhibits the Wnt/beta-catenin signalling pathway and is downregulated by CAF-derived exosomes carrying oncogenic miR-20a-5p in HCC.
circulation_biomarker_diagnosis_ns	36497090	hsa-mir-342	Alzheimer Disease	5p was dysregulated in human circulating sEVs from AD patients; sEV transfer of miR
circulation_biomarker_diagnosis_ns	36497052	hsa-mir-125a	Moyamoya Disease	CircZXDC sponges miR-125a-3p to increase ABCC6 expression, which induces ERS (endoplasmic reticulum stress), and subsequently regulates VSMC transdifferentiation from the contractive phenotype to the synthetic phenotype, contributing to the intima thickness of MMD vessels. Our findings provide insight into the pathophysiological mechanisms of MMD and indicate that the circZXDC-miR-125a-3p-ABCC6 axis plays a pivotal role in the progression of MMD.
other	36497036	hsa-mir-1274a	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1207	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1268	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36497036	hsa-mir-1274b	Prostatic Neoplasms	An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p).
other	36496421	hsa-mir-195	Adenocarcinoma of Lung	We also demonstrate that D-limonene-miRSREBP1/FASN axis is a potential preventive intervention for mediating the progression and development of LUAD induced by PM(2.5) exposure.
other	36496032	hsa-mir-342	Ischemic Stroke	SIGNIFICANCE: This study suggests that PEG11as regulates neuronal apoptosis by miR5p/PFN1 axis, which may contribute to our understanding of pathogenesis and provide a potential therapeutic option for cerebral I/R.
genetics_knock down_promote	36495604	hsa-mir-652	Carcinoma, Hepatocellular	3p, and the knockdown of TNRC6A restored repressed EMT and HCC metastasis caused by the inhibition of miR
other	36495516	hsa-mir-29a	Chronic Kidney   Disease	Then, Mir-29a-5p, sclerostin and fetuin-A are abnormally expressed in chronic kidney disease.
other	36495516	hsa-mir-29a	Vascular Calcification	Results showed that compared with the control group, the expression of mir-29a-5p and sclerostin in the study group was higher, and the expression of fetuin-A was lower, the difference was statistically significant (P < 0.05); The expression of mir-29a-5p, sclerostin and fetuin-A in calcified group was higher than that in non-calcified group, and the expression of fetuin-A was lower (P < 0.05); Mir-29a-5p and sclerostin showed positive correlation (r=6.776, P=0.011); The expression of mir-29a-5p and fetuin-A showed negative correlation (r=-5.326, P=0.001); The expression of mir-29a-5p and sclerostin showed negative correlation (r=-9.677, P=0.001); Mir-29a-5p and sclerostin were positively correlated with vascular calcification (r=0.695, P=0.001; r=0.715, P=0.001), and fetuin-A was positively correlated with vascular calcification (r = -0.953, P = 0.001).
lncRNA target	36495514	hsa-mir-144	Carcinoma, Hepatocellular	The liver tissue of miR-144 is low, the level of gene expression CCNB1 protein expression level is higher, the expression level in liver cancer cells directly influences the curative effect of hepatocellular carcinoma patients, the miR-144 gene can negative regulation CCNB1 protein, through this kind of negative adjustment to the biological behavior of liver cancer cells have a profound impact.
lncRNA target	36495510	hsa-mir-382	Colorectal Neoplasms	It is concluded that Circ_0022340 promoted colorectal cancer progression via recruiting HNRNPC to stabilize EBF1 mRNA and thereby activated SYT7 or miR5p/ELK1 axis, which might provide a novel target for CRC treatment.
transcription factor target	36495508	hsa-mir-29a	Renal Insufficiency, Chronic	Thus, miR-29a-5p/GSAP might be a potential target for the treatment of vascular calcification.
other	36495505	hsa-mir-1	Hypertension	The results showed that the apoptosis rate of myocardial cells in the miRNA-1 group decreased (0.710 /- 0.009661)% vs (1.066667 /- 0.02603)% compared with that in the spontaneous hypertension control group (P < 0.001).
other	36495504	hsa-mir-29a	Kidney Failure, Chronic	Mir-129 and Mir-29a-5p showed high expression in the patients with end-stage renal disease, and they also increased with the occurrence of vascular calcification, and they showed a positive correlation in the vascular calcification of end-stage renal disease.
circulation_biomarker_diagnosis_up	36495497	hsa-mir-193a	Aortic Aneurysm, Thoracic	In the current study, we discovered that miR-193a-5p was expressed at low levels in the blood of TAA patients.
epigenetics	36495416	hsa-mir-217	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	DNMT3A could be the molecular target of miR-217 by regulating PER2 gene methylation and getting involved with the occurrence and development of CML.
other	36495003	hsa-mir-155	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-203	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-146a	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-142	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
other	36495003	hsa-mir-146b	Periodontal Diseases	CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment.
target gene	36494581	hsa-mir-219	Ovarian Neoplasms	miR-219-5p attenuates cisplatin resistance of ovarian cancer by inactivating Wnt/β-catenin signaling and autophagy via targeting HMGA2.
lncRNA target	36494481	hsa-mir-34a	Carcinoma, Hepatocellular	Mechanistic studies suggest that ALDOA is a direct target of miR-34a-5p, which can inhibit glycolysis in hepatocellular carcinoma cells by targeting the 3'UTR of ALDOA.
other	36494341	hsa-mir-199a	Carcinoma, Renal Cell	Mechanistically, circPLIN2 not only increased the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, which ultimately resulted in ccRCC tumorigenesis and progression.
exosome	36494333	hsa-mir-197	Adenocarcinoma of Lung	In conclusion, LUAD cells-derived exosomal miR
other	36494326	hsa-mir-21	Crohn Disease	In conclusion, the level of miR-21 decreased in CD, resulting in an upregulated PI3K-Akt-mTOR signaling pathway, compromised immune tolerance, and elevated inflammation.
exosome	36494212	hsa-mir-17	Virus Diseases	EVs participated in TLR3-dependent antiviral immunity, protecting the host from viral infections through both EV-mediated functional delivery of miR-17 and direct virion neutralization after binding to virus ligands via surface receptors, including LDLR and ICAM-1.
exosome	36493861	hsa-mir-146a	Peripheral Nerve Injuries	CONCLUSION: Our study confirmed that miR-146a-5p was significantly decreased in SC-Exos under the ischemia-hypoxic microenvironment of the injury site after PNI, which mediated its shift from promoting macrophage M2 polarization (anti-inflammation) to promoting M1 polarization (pro-inflammation), thereby limiting axonal regeneration and functional recovery.
genetics_knock down_promote	36493845	hsa-mir-493	Esophageal Squamous Cell Carcinoma	Moreover, our multiple gain-and loss-of-functional experiments proved that a combination of miR
genetics_overexpression_promote	36484970	hsa-mir-19b	Glioma	The glioma patients exhibited overexpressed miR-19b-3p and poorly-expressed SOCS3.
lncRNA target	36484486	hsa-mir-515	Stomach Neoplasms	CircPDSS1 conferred DDP resistance through the miR
circulation_biomarker_diagnosis_down	36484399	hsa-mir-340	Duane Retraction Syndrome	In the blood of DR patients and the DR model, lncRNA SNHG1 was increased and miR
genetics_knock down_promote	36484173	hsa-mir-873	Esophageal Squamous Cell Carcinoma	CONCLUSION: CircLPAR3 knockdown suppressed ESCC cell growth, metastasis, and Warburg effect by miR
target gene	36484007	hsa-mir-29c	Stomach Neoplasms	miR-29c inhibits metastasis of gastric cancer cells by targeting VEGFA.
other	36483920	hsa-mir-23b	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-155	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-146a	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-124	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-195	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
other	36483920	hsa-mir-24	Hypertension, Pulmonary	5p, and hsa-mir-23b-3p were associated with HPH.
exosome	36483681	hsa-mir-134	Squamous Cell Carcinoma of Head and Neck	We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). This study hypothesize that OSCC-CSC-derived small extracellular vesicles (OSCC-CSC-sEVs) transfer a ceRNA of miR-134 and consequently promote M2 macrophage polarization by targeting LAMC2 via the PI3K/AKT pathway through in vitro and in vivo experiment methods.
other	36482859	hsa-mir-125	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-21	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-200b	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-21	Periodontitis	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05).
other	36482859	hsa-mir-7a	Periodontitis	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05).
other	36482859	hsa-mir-7a	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
other	36482859	hsa-mir-100	Cardiovascular Diseases	More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05).
lncRNA target	36482855	hsa-mir-372	Epilepsy	CONCLUSION: Our study suggests that targeting HOXA-AS2 could alleviate cellular damages in the epileptic model by regulating miR3p/STAT3 axis.
other	36482742	hsa-mir-1290	Carcinoma, Non-Small-Cell Lung	In summary, circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis.
circulation_biomarker_diagnosis_up	36482739	hsa-mir-455	Colorectal Neoplasms	3p expression was both higher in the serum and tumor tissues of CRC patients.
other	36482542	hsa-mir-140	Squamous Intraepithelial Lesions of the Cervix	CONCLUSIONS: The differential expression and potential effects of the lncRNA BACH1-IT1/miR5p/VEGFA axis, key genes, VEGFA and FOS, and MAPK signaling in CIN were clarified, and the occurrence and potential effects of CIN were further clarified.
lncRNA target	36482494	hsa-mir-142	Ovarian Neoplasms	Overall, our data demonstrate that hsa_circ_0000119 facilitated ovarian cancer development through increasing CDH13 expression via promoting DNMT1 expression by sponging miR
genetics_knock down_promote	36482354	hsa-mir-503	Pancreatic Carcinoma	5p down-regulation and ANLN up-regulation reversed the effects of LINC00460 knockdown on inhibiting the proliferation, migration and invasion, and on promoting the apoptosis, G0/G1 phase arrest, and the sensitivity of PC cells to the cytotoxicity of CD8(+) T cells.
transcription factor target	36482325	hsa-mir-431	Carcinoma, Hepatocellular	Expression of HHIP, a possible miR5p target gene, was significantly downregulated in HCC cells.
circulation_biomarker_diagnosis_ns	36482069	hsa-mir-34a	Hepatitis B, Chronic	Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum.
circulation_biomarker_diagnosis_ns	36482069	hsa-mir-34a	Fibrosis	miR-34a-5p inhibitor undo protective regulation of sh-CCAT2 in liver fibrosis. Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum.
genetics_overexpression_promote	36481751	hsa-mir-185	Hyperlipidemias	3p overexpression or MAML1 silencing reduced levels of serum lipids, mitigated oxidative stress and inflammatory response, relieved lipid accumulation and pathological morphology in liver tissues in hyperlipidemia rats; while up-regulated MAML1 reversed the effects of augmented miR
transcription factor target	36481664	hsa-mir-29a	COVID-19	Intriguingly, hsa-miR-29a-3p significantly downregulated in severe COVID-19 was predicted to bind the 3'-untranslated regions of both IL17RA and THBS1 mRNAs. These findings strongly suggest that dysregulated expression of THBS1, IL17RA, and hsa-miR-29a-3p involves severe COVID-19.
genetics_knock down_promote	36481629	hsa-mir-1	Ovarian Neoplasms	3p mimics on enhancing the sensitivity of human ovarian cancer cells to Erastin-induced or RSL3-induced ferroptosis was abrogated by overexpression of FZD7(P<0.05 or P<0.01).
other	36481589	hsa-mir-27a	Infertility, Female	In summary, our findings reveal that miR-27a-3p is a novel regulator of E2 synthesis and may predict litter size of Hu sheep, providing insight into mechanisms underlying granulosa cell function and female fertility.
lncRNA target	36481473	hsa-mir-936	Ovarian Neoplasms	These data suggested that circ_0021573 might promote the malignant phenotypes of ovarian cancer cells by functioning as a ceRNA for miR-936 to induce CUL4B, which provided a promising target for the prevention and inhibition of ovarian cancer.
exosome	36481205	hsa-mir-27a	Arthritis, Rheumatoid	Summarily, exosomal lncRNA TRAFD1-4:1 derived from RA-FLSs suppressed chondrocyte proliferation and migration through degrading CECM by upregulating CXCL1 as a sponge of miR-27a-3p.
other	36480308	hsa-mir-21	Prostatic Neoplasms	Herein, a solution-gated graphene transistor (SGGT) biosensor for the ultrasensitive and rapid quantification detection of the early prostate cancer-relevant biomarker, miRNA-21 is reported.
genetics_overexpression_promote	36479734	hsa-mir-199b	Carcinoma, Hepatocellular	Moreover, miR-199b-5p could target OTX1, and OTX1 overexpression reverted the repressive impact of miR-199b-5p mimic on the malignancy of HCC cells. In conclusion circKIAA1429 might promote HCC progression via regulating miR-199b-5p/OTX1 axis.
lncRNA target	36479657	hsa-mir-646	Pancreatic Carcinoma	Delivery of circ_0086375 by nanoparticles suppresses the tumorigenicity of pancreatic cancer by miR-646/SLC4A4 axis, suggesting a new potential target for future pancreatic cancer treatment.
lncRNA target	36479622	hsa-mir-101	Glioma	Therefore, targeting SPRY4-IT1/miR
circulation_biomarker_prognosis_up	36478451	hsa-mir-15b	Prostatic Neoplasms	In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively).
circulation_biomarker_prognosis_up	36478451	hsa-mir-106b	Prostatic Neoplasms	In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively).
other	36478437	hsa-mir-23a	Infertility, Female	Overall, our findings suggest that the SNVs g.-283G>C and g.-271C>T in the miR-23a promoter are causal variants affecting GC apoptosis and miR-23a may be a potential small-molecule nonhormonal drug for regulating female fertility.
lncRNA target	36478207	hsa-mir-494	Pneumonia, Mycoplasma	CONCLUSION: Overall, by suppressing HTR8/SVneo cell growth and migration via the miR3p/PTEN axis and other mechanisms, LINC00534 offers new insight into PE pathogenesis.
other	36477577	hsa-mir-186	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-144	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-206	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-203a	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
other	36477577	hsa-mir-205	Diabetes Mellitus	RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001).
lncRNA target	36477451	hsa-mir-148	Carcinoma, Renal Cell	CONCLUSION: Curcumin can inhibit the proliferation of renal cell carcinoma by regulating the miR-148/ ADAMTS18 axis through the suppression of autophagy in vitro and in vivo. There may exist a positive feedback loop between miR-148 and ADAMTS18 gene in RCC.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	beta-Thalassemia	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Anemia, Iron-Deficiency	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Anemia, Aplastic	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
circulation_biomarker_diagnosis_ns	36476908	hsa-mir-451	Myelodysplastic Syndromes	Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome.
genetics_overexpression_promote	36476884	hsa-mir-29a	Leukemia	miR-29a-3p could target and regulate the expression of HDGF, while overexpression of HDGF reversed the inhibitory effect of miR-29a-3p overexpression on the proliferation and promotion effect on the apoptosis of leukemia cells E6-1.
genetics_overexpression_promote	36476884	hsa-mir-29a	Precursor Cell Lymphoblastic Leukemia-Lymphoma	CONCLUSION: Overexpression of miR-29a-3p can inhibit the proliferation and promote the apoptosis of ALL cells E6-1, and its mechanism may be related to the regulation of HDGF expression.
other	36476775	hsa-mir-146a	Diabetes Mellitus, Type 2	The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05.
other	36476775	hsa-mir-146a	Tuberculosis	The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05.
circulation_biomarker_diagnosis_ns	36476595	hsa-mir-16	Schizophrenia	A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people.
transcription factor target	36476351	hsa-mir-125b	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: Overall, our findings demonstrated novel functions and mechanisms underlying DDP resistance in NSCLC through the TRIM28/miR-125b-5p/CREB1 axis.
circulation_biomarker_diagnosis_up	36476264	hsa-mir-375	Pancreatic Carcinoma	Subcellular location analysis indicated that AK4P1 was mainly located in cytoplasm, in which AK4P1 might competitively bind to tumour suppressive miR-375 in pancreatic adenocarcinoma.
other	36476239	hsa-mir-19a	Carcinoma, Hepatocellular	Furthermore, a well-established circ_002136 ceRNA regulatory network was constructed, namely circ_002136 blocked miR-19a-3p expression, elevated RAB1A expression activity and stimulated HCC development. Finally, high levels of circ_002136 or RAB1A, as well as low levels of miR-19a-3p, negatively affected HCC patient survival.
circulation_biomarker_diagnosis_ns	36475430	hsa-mir-222	Pre-Eclampsia	3p expression in total plasma and plasma Exos, which both have high diagnostic efficiency for PE.
genetics_overexpression_promote	36475330	hsa-mir-122	Obesity	The miRNA hsa-miR5p (p < 0.05) was overexpressed in the obese group.
other	36475295	hsa-mir-381	Breast Neoplasms	A prediction model consisting of combination of miR-381 and Ki-67 and TN indicators could predict disease progression more effectively.
other	36474808	hsa-mir-140	Osteoarthritis	Here we present functional studies of canonical microRNA3p and two of its most prevalent isomiRs, a 5' isomiR and a 3' isomiR, in an inflammation-induced model of osteoarthritis (OA).
genetics_GWAS	36474749	hsa-mir-21	Neonatal Sepsis	AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis.
genetics_GWAS	36474749	hsa-mir-181b	Neonatal Sepsis	AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis.
lncRNA target	36474748	hsa-mir-221	Carcinoma, Hepatocellular	CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively.
lncRNA target	36474748	hsa-mir-122	Carcinoma, Hepatocellular	CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively.
circulation_biomarker_diagnosis_up	36474713	hsa-mir-103a	Venous Thrombosis	RESULTS: The upregulated expression levels of lncRNA XIST and HMGB1 and downregulated level of miR-103a-3p were found in the plasma of DVT patients and IL-1beta-treated HUVECs. CONCLUSION: lncRNA XIST sponged miR-103a-3p improving HMGB1 expression to exacerbate DVT by activating the ROS/NF-kappaB signaling pathway.
target gene	36474621	hsa-mir-204	Psoriasis	Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis.
transcription factor target	36474573	hsa-mir-27a	Diabetic Nephropathies	CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR.
other	36474573	hsa-mir-33a	Kidney Diseases	Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO.
transcription factor target	36474573	hsa-mir-27a	Kidney Diseases	CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR.
other	36474573	hsa-mir-33a	Diabetic Nephropathies	Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO.
circulation_biomarker_diagnosis_up	36474147	hsa-mir-552	Carcinoma, Hepatocellular	METTL14 promoted circFUT8 m6A modification and facilitated its nuclear export to the cytoplasm, where M1 macrophages regulated the circFUT8/miR3p/CHMP4B pathway, thereby suppressing HCC progression.
genetics_overexpression_promote	36474029	hsa-mir-4731	Cardiomegaly	The rescue experiments showed that miR-4731 overexpression attenuated the protective effects of circ_0018553 overexpression on the cardiac hypertrophy induced by Ang II; SIRT2 silencing also attenuated the protective effects of miR-4731 inhibition on the Ang II-induced cardiac hypertrophy.
genetics_knock down_promote	36473889	hsa-mir-27a	Femur Head Necrosis	The expressions of Runx2 in BMSCs and steroid-induced ONFH rats was significantly up-regulated, while IL-6, TNF-alpha, PPAR-gamma and ApoA5 were down-regulated with miR-27a overexpression.
circRNA target	36473706	hsa-mir-340	Cholangiocarcinoma	CONCLUSION: Hsa_circ_0,019,054 deficiency could attenuate the proliferation and glycolysis of ICC cells via miR
genetics_knock down_promote	36473369	hsa-mir-96	Lung Neoplasms	5p expression, it could promote or inhibit the proliferation, invasion and metastasis of H1299 cells after LDB2 knockdown or overexpression and regulate the expression of cyclinD1, MMP9, Bcl-2, and Bax via ERK1/2 signaling pathway.
genetics_overexpression_promote	36473368	hsa-mir-653	Laryngeal Papilloma	5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells.
other	36473367	hsa-mir-520e	Osteosarcoma	Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma.
other	36473367	hsa-mir-520b	Osteosarcoma	Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma.
lncRNA target	36471281	hsa-mir-29a	Prostatic Neoplasms	In summary, we demonstrated that LINC00852 played a key role in promoting the prostate cancer, and LINC00852/miR-29a-3p/JARID2 axis could be used as a target for prostate cancer treatment.
lncRNA target	36471277	hsa-mir-214	Esophageal Neoplasms	CONCLUSIONS: These results further support the tumor-suppressive role of miR
other	36470669	hsa-mir-22	Carcinoma, Hepatocellular	The mRNA expression of FGD5-AS1, LINC00858, SNHG16, and UBE4B was higher in the HCC cell lines (7721 and HepG2) than in the normal hepatocyte line (LO2), and the expression of hsa-miR3p mRNA showed a decreasing trend.
lncRNA target	36470227	hsa-mir-506	Neuralgia	3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis.
lncRNA target	36470227	hsa-mir-506	Brachial Plexus Avulsion 	3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis.
other	36469564	hsa-mir-200	Biliary Tract Neoplasms	Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer.
transcription factor target	36469307	hsa-mir-210	Obesity	Thus, miR3p inhibition in ATMs could serve as a novel therapeutic strategy for managing obesity-induced type 2 diabetes.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-21	Lupus Erythematosus, Systemic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-21	Anemia, Hemolytic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-210	Lupus Erythematosus, Systemic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
circulation_biomarker_diagnosis_ns	36469203	hsa-mir-210	Anemia, Hemolytic	CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases.
exosome	36468636	hsa-mir-181a	Osteosarcoma	The results showed that exosomal miR-181a-5p derived from osteosarcoma cells induced polarization of M2 macrophages via targeting RORA.
other	36468451	hsa-mir-223	Colorectal Neoplasms	Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively.
other	36468451	hsa-mir-106a	Colorectal Neoplasms	Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively.
lncRNA target	36468227	hsa-mir-214	Myocardial Reperfusion Injury	MicroRNA3p protects against myocardial ischemia-reperfusion injury by targeting demethylase lysine demethylase 3A.
other	36468026	hsa-let-7	Pulmonary Disease, Chronic Obstructive	AIFM1-FKBP1A pathway also indicates new hypotheses of COPD pathology.
circRNA target	36467610	hsa-mir-124	Anxiety Disorders	3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity.
circRNA target	36467610	hsa-mir-124	Irritable Bowel Syndrome	3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity.
target gene	36467343	hsa-mir-95	Uterine Cervical Neoplasms	MiR-95-3p acts as a prognostic marker and promotes cervical cancer progression by targeting VCAM1.
therapeutic target	36467335	hsa-mir-345	Breast Neoplasms	Silencing the expression of lncRNA SNHG15 may be a novel therapeutic approach in human breast cancer through regulating miR-345-5p.
transcription factor target	36467048	hsa-mir-125b	Carcinoma, Non-Small-Cell Lung	Mechanistically, Curcumol downregulated the expression of SP1 (specificity protein 1) while upregulated miR-125b-5p, followed by decreasing VEGFA expression in NSCLC cells. Collectively, our study revealed that Curcumol inhibited cell growth and angiogenesis of NSCLC in vitro and in vivo, possibly through SP1/miR-125b-5p/VEGFA regulatory mechanism.
lncRNA target	36467040	hsa-mir-185	Heart Failure	3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR
circulation_biomarker_prognosis_ns	36466111	hsa-mir-210	Carcinoma, Pancreatic Ductal	Further detection of PDAC plasma exosomal miR-210 suggests that exosomal miR-210 expression was high and significantly associated with vascular invasion and TNM stage and was an independent risk factor for PDAC overall survival.
circulation_biomarker_diagnosis_ns	36465705	hsa-mir-210	Diabetes Mellitus, Type 2	This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then investigating the underlying mechanism of circulating miR-210 in T2DM.
transcription factor target	36464444	hsa-mir-155	Cardiovascular Diseases	In this work, a novel label-free and signal-off electrochemical biosensor based on efficient target-trigger T-structure recycling with dual strand displacement amplification (T-DSDA) was constructed for sensitive detection of miRNA-155 that related to cardiovascular diseases.
other	36464432	hsa-mir-455	Triple Negative Breast Neoplasms	The ECL sensing system was used to detect miRNA3p in the triple-negative breast cancer tumor tissues.
circulation_biomarker_diagnosis_up	36463825	hsa-mir-1246	Carcinoma, Non-Small-Cell Lung	Further investigation indicated that miR1246 was the most enriched microRNA in NSCLC-derived exosomes and mediated the partial effects of exosomes on microglia. Notably, miR1246 was also upregulated in the plasmatic exosomes of NSCLC patients.
lncRNA target	36463760	hsa-mir-206	Breast Neoplasms	Taken together, our results proved that the lncRNA COX10-DT could function via the COX10-DT/miR-206/BDNF axis, thereby promoting the development of breast cancer.
lncRNA target	36463687	hsa-mir-146a	Tendinopathy	Targeting the AC108925/miR-146a-3p axis might be a latent way to treat tendinopathy.
genetics_knock down_promote	36463188	hsa-mir-181a	Breast Neoplasms	Gain- and loss-of-function experiments were performed to explore the role of miR-181a in BC progression with the involvement of the AKT signaling pathway.
other	36463118	hsa-mir-122	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-29	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-155	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36463118	hsa-mir-196	Hepatitis C	RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients.
other	36462649	hsa-mir-140	brachydactyly type D	Results found that the expression of miR-140 in the articular cartilage of the KBD group was lower than that of the control group. Moreover, the occurrence of KBD might be related to the decreased expression of miR-140 in articular cartilage.
genetics_knock down_suppress	36462557	hsa-mir-125a	Carcinoma, Renal Cell	CONCLUSION: Circ_0000069 knockdown inhibited the carcinogenesis of RCC by regulating miR-125a-5p/SLC1A5 axis.
lncRNA target	36462499	hsa-mir-24	Melanoma	3p/MAPK1 axis in CMM, and revealed an alternative target for the diagnosis and treatment of CMM.
other	36462338	hsa-mir-197	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
other	36462338	hsa-mir-483	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
other	36462338	hsa-mir-885	Cirrhotic Cardiomyopathy	3p), were found to be the major potential genes involved in CCM regulation.
lncRNA target	36462326	hsa-mir-205	Prostatic Neoplasms	5p inhibitors, siErBB3 could oppose SC-triggered pro-apoptotic effects on PCa cells.
circulation_biomarker_diagnosis_ns	36462101	hsa-mir-375	Carcinoma, Non-Small-Cell Lung	miR-375, SHOX2 methylation, smoking history, neuron-specific enolase (NSE), and CYFRA21-1 levels were risk factors for NSCLC; the risk of NSCLC increased 25.763 times for each unit increase in plasma miR-375 level (OR = 25.763, CI: 1.726-384.529), and the risk of NSCLC increased 4.096 times for each unit increase in SHOX2 methylation (OR = 4.096, CI: 1.195-14.036).
circulation_biomarker_diagnosis_ns	36461796	hsa-mir-203	psoriasis 1	It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients.
circulation_biomarker_diagnosis_ns	36461796	hsa-mir-146a	psoriasis 1	It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients.
exosome	36461670	hsa-mir-217	Urinary Bladder Neoplasms	We conclude that bladder cancer tissue-derived exosomes inhibit ferroptosis of T24 bladder cancer cells by transporting miR-217.
genetics_GWAS	36461613	hsa-mir-587	Adenocarcinoma of Lung	Herein, the expression of lncRNA A2M-AS1, microRNA (miRNA) miR-587, and bone morphogenetic protein 3 (BMP3) in LUAD cell lines and tissues were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting.
other	36461592	hsa-mir-124	Alzheimer Disease	3p.
other	36461592	hsa-mir-124	Hyperuricemia	3p.
lncRNA target	36460840	hsa-mir-155	Ischemic Stroke	CONCLUSION: OIP5-AS1 suppressed oxidative stress and inflammatory response to alleviate cell injury caused by OGD/R induction in HMC3 and SH-SY5Y cells through regulating miR5p/IRF2BP2 axis, which might offer novel targeted molecules for ischemic stroke therapy.
transcription factor target	36460813	hsa-mir-205	Carcinoma, Hepatocellular	The study clearly reflects that hsa-mir5p is the signature miRNA for positively regulating angiogenesis in HCC through VEGFA.
genetics_overexpression_promote	36460812	hsa-mir-146b	Multiple Myeloma	The inhibitory effects of NDNF upregulation on MM cell growth, colony formation, and migration were partially abolished by miR-146b-3p overexpression.
lncRNA target	36460802	hsa-mir-23a	Glioma	Collectively, these data suggest that GAS5 functions as a suppressor in GSCs by targeting the miR-23a/E-cadherin axis, which may be a promising therapeutic target against glioma.
genetics_knock down_promote	36460200	hsa-mir-4306	Intervertebral Disc Degeneration	As expected, MIR4306 overexpression inhibited ECM degradation in degenerated NPCs by downregulating EPAS1.
circRNA target	36459832	hsa-mir-876	Esophageal Neoplasms	CONCLUSION: Circ_0001686 contributed to the progression and radioresistance of esophagus cancer cells via regulating SPIN1 expression by targeting miR
genetics_overexpression_promote	36459592	hsa-mir-143	Dementia, Vascular	Overexpression of miR
other	36459290	hsa-mir-21	Breast Neoplasms	RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively.
circulation_biomarker_diagnosis_ns	36459290	hsa-mir-145	Breast Neoplasms	CONCLUSION: Based on our results, we conclude that the detection of serum miRNA-145, -382 and -21 as a panel along with glutamic acid, and circulating HER2 concentrations could be useful as a non-invasive diagnostic profiling for early prediction of breast cancer in Egyptian patients.
other	36459290	hsa-mir-382	Breast Neoplasms	RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively.
transcription factor target	36459288	hsa-mir-588	high grade glioma	CONCLUSIONS: MiR-588 regulated the behaviors of hypoxic glioma cells by targeting ROBO1.
lncRNA target	36459288	hsa-mir-588	Carcinoma, Hepatocellular	MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive.
lncRNA target	36459288	hsa-mir-588	Glioblastoma	MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive.
lncRNA target	36459268	hsa-mir-30	Colorectal Neoplasms	3p/CNBP axis in CRC, highlighting the potential of circPACRGL as a therapeutic target for colorectal cancer.
other	36459254	hsa-mir-155	Periodontitis	The result suggested that miRNA-155 does not affect the expression of MITF gene in the process of osteoclastogenesis in localized stage III/IV periodontitis within this study design and limitations.
lncRNA target	36458392	hsa-mir-449a	Peripheral Nerve Injuries	CONCLUSIONS: BMSCs can modulate NF-kappaB signaling pathway by targeting miR-449a, so as to reduce the inflammatory response to peripheral nerve injury and repair nerve injury.
genetics_GWAS	36457982	hsa-mir-155	Behcet Syndrome	MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p &lt; 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021).
genetics_GWAS	36457982	hsa-mir-146a	Behcet Syndrome	MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p &lt; 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021).
other	36457981	hsa-mir-125b	Cholesteatoma	Low expression of microRNA-125b enhances the expression of STAT3 and contributes to cholesteatoma growth.
lncRNA target	36457977	hsa-mir-20a	Osteoporosis	MATERIAL AND METHODS: The expression of MALAT1 and miR-320a was determined using RT-PCR in bone tissue derived from female SD (Sprague Dawley) rats with osteoporosis. CONCLUSIONS: Downregulated MALAT1 and upregulated miR-320a expression play an important role in the pathological process of osteoporosis, via inhibition of the osteogenic differentiation of BMSCs.
other	36457973	hsa-mir-23b	Osteoporosis	It has been reported previously that miR-23b-3p is involved in osteoporosis and in regulation of differentiation of osteoblasts.
other	36457880	hsa-let-7e	Inflammation	CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway.
other	36457880	hsa-mir-20a	Inflammation	CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway.
circulation_biomarker_diagnosis_ns	36457743	hsa-mir-222	Carcinoma, Hepatocellular	The serum and tissue expression of miRNAs (Let-7a, miR-26a, miR-124, miR-155, miR-221, miR-222, and miR-340) were differentially expressed in HCC patients (p &lt; 0.05).
other	36457244	hsa-mir-454	Pancreatic Carcinoma	RESULTS: We revealed CDK6 might be an oncogene in PC, and the HOXA11-AS /NR2F1-AS1- miR3p axis was identified as the possible upstream ncRNA-associated pathway of CDK6 in PC.
other	36457077	hsa-mir-24	Colorectal Neoplasms	In follow-up experiments, we demonstrate that miR3p promotes CRC cell survival in multiple cell contexts.
genetics_knock down_promote	36457055	hsa-mir-8114	Seizures	Moreover, both circ_0001293 knockdown and miR-8114 overexpression reversed the beneficial effects of HsTx2 on inflammation, epilepsy progression, and the MAPK and NF-kappaB signaling pathways in vivo. CONCLUSIONS: HsTx2 suppressed PTZ-induced epilepsy by ameliorating inflammation in astrocytes via the circ_0001293/miR-8114/TGF-beta2 axis.
transcription factor target	36457036	hsa-mir-378a	Colorectal Neoplasms	Phenotypically, by reducing polyamine synthesis, miR-378a induced apoptosis and inhibited proliferation and migration of CRC cells, while disrupting the association of miR-378a with FOXQ1 and ODC1 offset the effects of miR-378a, suggesting that FOXQ1 and ODC1 were required for miR-378a to inhibit CRC cell growth.
lncRNA target	36457028	hsa-mir-133a	Uterine Cervical Neoplasms	369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3.
lncRNA target	36457028	hsa-mir-379	Uterine Cervical Neoplasms	369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3.
exosome	36457020	hsa-mir-142	hereditary diffuse gastric cancer	For accurate diagnosis of gastric cancer patients, a combination of LDT-CHA and a panel of four sEV-miRNAs (sEV-miR-1246, sEV-miR-21, sEV-miR
other	36456979	hsa-mir-576	Esophageal Neoplasms	5p/AHR were critical molecular pathways related to the radiosensitivity of esophageal cancer.
transcription factor target	36456413	hsa-mir-663a	Fibrosis	CONCLUSION: Our study identified lnc-C18orf26-1 and miR-663a as promising therapeutic targets for hepatic fibrosis.
circulation_biomarker_prognosis_ns	36456138	hsa-mir-21	Ovarian Neoplasms	CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer.
circulation_biomarker_prognosis_ns	36456138	hsa-mir-1	Ovarian Neoplasms	CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer.
exosome	36455873	hsa-mir-584	Postoperative Cognitive Complications	CONCLUSIONS: Sevoflurane-induced POCD-associated exosomes delivered miR
other	36455651	hsa-mir-152	Obesity	3p were associated with insulin resistance.
other	36455651	hsa-mir-423	Obesity	3p were associated with insulin resistance.
other	36455323	hsa-mir-6238	Acute Lung Injury	Collectively, our findings suggest that miR-6238 is a novel regulator of pulmonary inflammation and a putative biomarker that distinguishes PM-induced ALI from endotoxin (LPS/PTG)-mediated ALI.
genetics_overexpression_suppress	36455140	hsa-mir-143	Wilms Tumor	Meanwhile, overexpression of k-Ras reversed the inhibitory effects on WT cells induced by miR
lncRNA target	36454533	hsa-mir-210	Cholangiocarcinoma	It was further confirmed in vivo that miR-210 shuttled by tumor cell-derived EVs could specifically inhibit RECK expression, which promotes growth, metastasis and chemoresistance of CCA cells.
genetics_knock down_promote	36454505	hsa-mir-433	Glioma	3p overexpression-mediated effects on glioma cell clonogenicity, migration, and apoptosis.
circulation_biomarker_diagnosis_down	36454178	hsa-mir-191	Alzheimer Disease	5p in plasma/serum has been identified as a novel and promising noninvasive diagnostic biomarker for AD.
other	36454035	hsa-let-7d	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
other	36454035	hsa-mir-29a	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
other	36454035	hsa-mir-181b	Pulmonary Fibrosis, Idiopathic 	RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF.
genetics_knock down_suppress	36453878	hsa-mir-361	Esophageal Neoplasms	3p inhibitor rescued the anti-tumour effect of BBOX1-AS1 knockdown on the progression of EC.
other	36452459	hsa-let-7b	Leukemia	CTDSP1 was significantly downregulated in T-ALL compared to normal controls, which might be originated from the hyperediting of hsa-let-7b-5p in T-ALL.
other	36452459	hsa-mir-21	Leukemia	5p decreased in chronic lymphocytic leukemia patients with radiation treatments.
other	36452459	hsa-mir-155	Leukemia	5p decreased in chronic lymphocytic leukemia patients with radiation treatments.
other	36452144	hsa-mir-214	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-mir-148a	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-let-7b	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36452144	hsa-mir-26a	Schimke immunoosseous dysplasia	By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen.
other	36451863	hsa-mir-92a-2	Multiple Myeloma	3p expression.
lncRNA target	36451861	hsa-mir-126	Triple Negative Breast Neoplasms	Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors.
lncRNA target	36451861	hsa-mir-126	Pancreatic Carcinoma	Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors.
other	36451157	hsa-mir-17	Neuroectodermal Tumors, Primitive	The sperm sRNA sequencing revealed that the expression of the developmental miR92 cluster and the Sfmbt2 miRNA cluster was downregulated in the OEE group.
lncRNA target	36451051	hsa-mir-580	Stomach Neoplasms	SOX2-activated Linc-ROR serves as a cancer suppressor to restrain GCa progression in vitro via the miR
genetics_knock down_suppress	36450557	hsa-mir-214	Reperfusion Injury, Ischemia	SOX6 knockdown overturned the circTRRAP overexpression-induced effects in AC16 cardiomyocytes.In conclusion, the silence of circTRRAP was implicated in Sal B-mediated cardioprotective effects against I/R injury by regulating the miR3p/SOX6 axis.
circulation_biomarker_diagnosis_ns	36450556	hsa-mir-22	Graft Occlusion, Vascular	Peripheral blood samples were acquired from patients with in-stent restenosis (ISR) after percutaneous coronary intervention (PCI), with subsequent quantitative reverse transcription (qRT) -polymerase chain reaction (PCR) and Western blot analyses of miR
circulation_biomarker_diagnosis_ns	36450556	hsa-mir-22	Ciliary Motility Disorders	The peripheral blood of patients with ISR after PCI had low expression of miR
transcription factor target	36450556	hsa-mir-22	Cardiovascular Diseases	Conclusively, miR3p could repress VSMC proliferation, phenotypic transformation, and migration by targeting TOMM40, which might be a possible treatment candidate for restenosis after PCI in patients with cardiovascular disease.
circulation_biomarker_diagnosis_ns	36449688	hsa-mir-590	Reperfusion Injury, Renal Ischemia	RESULTS: miR3p was highly enriched in the plasma exosomes of young AKI patients after cardiac surgery.
other	36449366	hsa-mir-122	Hepatitis C	MicroRNA-122 (miR-122) is the most abundant miRNA in the liver and has been linked to the development of hepatocellular carcinoma and hepatitis C virus (HCV) infection.
lncRNA target	36449143	hsa-mir-488	Stomach Neoplasms	Overall, HULC re-expression elicited by miR-488 inhibition can enhance EZH2-H3K27me3 enrichment in the p53 promoter and repress the p53 expression, thus promoting the growth and metastasis of GC.
transcription factor target	36448837	hsa-mir-15a	Acute Lung Injury	The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response.
transcription factor target	36448837	hsa-mir-15a	Sepsis	The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response.
exosome	36448712	hsa-mir-518a	Ovarian Neoplasms	OC-derived exosomal circNFIX promoted angiogenesis by regulating the Janus-activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR-518a-3p/TRIM44 axis in HUVECs.
other	36448711	hsa-mir-223	Liver Neoplasms	Herein, we propose a simple and sensitive mass spectrometric method for the multiplex detection of nucleic acid and protein, in which liver cancer-related biomarkers miRNA 223 and alpha-fetoprotein (AFP) were selected as model analytes.
genetics_GWAS	36448327	hsa-mir-124	Ischemic Stroke	Finally, the suppressed of PARP1 was induced by gain-binding ability of miR5p through 3'UTR directly binding.Conclusions: In conclusion, our study demonstrates that the SNP rs8679 in PARP1 3'-UTR might act as a protective factor for the outcome of patients with ischemic stroke.
other	36447429	hsa-mir-223	Melanoma	miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells.
other	36447429	hsa-mir-181a	Melanoma	miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells.
target gene	36447254	hsa-mir-506	Stomach Neoplasms	Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism.
lncRNA target	36447214	hsa-mir-200b	Stomach Neoplasms	The StarBase database was used to predict that 3 pseudogenes and 7 lncRNAs might inhibit the hsa-miR-200b-3p-COL5A2 axis in gastric cancer. CONCLUSIONS: We elucidated the regulatory role of the pseudogenes/lncRNA-hsa-miR-200b-3p-COL5A2 network in gastric cancer progression and constructed a nomogram.
circulation_biomarker_diagnosis_ns	36446758	hsa-mir-148a	Bone Diseases	Finally, the miR-148a level was found to be positively correlated with beta-CTX in postmenopausal osteoporosis (PMOP) serum specimens. In osteoclast-related bone metabolic diseases such as PMOP, miR-148a may be an attractive therapeutic target in the future.
other	36446162	hsa-mir-4455	Cognitive Dysfunction	The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy.
other	36446162	hsa-let-7b	Cognitive Dysfunction	The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy.
lncRNA target	36446154	hsa-mir-1322	Myocardial Ischemia	CONCLUSION: Our results suggested that miR-1322 can protect against the myocardial ischemia via LRP8/PI3K/AKT pathway.
genetics_overexpression_suppress	36445955	hsa-mir-34a	Carcinoma, Hepatocellular	Overexpression of miR-34a-5p counteracts CSC properties and enhances radiosensitivity in HCC.
other	36445630	hsa-mir-6085	Cerebral Infarction	Celastrol ameliorated OGD/R-induced HBMEC apoptosis and oxidative stress by circDLGAP4/miR-6085/GDF11 pathway, supporting the use of Celastrol as a therapeutic agent for cerebral infarction.
genetics_knock down_promote	36445573	hsa-mir-490	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Knockdown of MAPKAPK5-AS1 inhibited the aggressive tumor phenotypes through miR
lncRNA target	36445120	hsa-let-7b	Colonic Neoplasms	Let-7b-5p was found to inhibit proliferation, migration, and invasion of colon cancer cells targeting NKD1. This research revealed a novel mechanism by which the let-7b-5p-NKD1-APC-beta-catenin signaling pathway inhibited colon cancer cell progression.
genetics_overexpression_promote	36445107	hsa-mir-548ag	Obesity	Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals.
genetics_overexpression_promote	36445107	hsa-mir-548ag	Endometrial Neoplasms	Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals.
tissue_expression_ns	36444993	hsa-mir-181a-2	Myelodysplastic Syndromes	Although abnormal microRNA expression has been implicated in MDS, the exact role of miR-181a3p has not been entirely elucidated. Here, we investigated miR-181a3p levels in bone marrow (BM), and described its utility as a potential indicator for MDS diagnosis and prognosis. METHODS: We evaluated miR-181a3p expression in BM samples of 54 newly diagnosed MDS cases, 16 sAML patients and 32 healthy donors and then assessed its association with clinical characteristics and its potential value for MDS diagnosis and prognosis. RESULTS: Compared with healthy controls, miR-181a3p levels were decreased in the total cohort of MDS patients. Additionally, in MDS patients with secondary AML (sAML), miR-181a3p was over-expressed relative to levels in those without this form. Further, multivariate analysis indicated that miR-181a3p was an independent prognostic index for MDS with respect to OS. CONCLUSION: Decreased miR-181a3p expression in MDS patients may be considered as one of the underlying markers reflecting MDS progression and prognosis.
genetics_knock down_promote	36444938	hsa-mir-6838	Uterine Cervical Neoplasms	Functional investigations revealed that CERS6-AS1 knockdown inhibited proliferation and invasion, and promoted apoptosis in CC cells, which was reversed by miR
genetics_overexpression_promote	36444911	hsa-mir-708	Retinoblastoma	Furthermore, retinoblastoma cells overexpressing miR-708 exhibited a markedly lower migratory rate and invasiveness compared to negative control cells.
circRNA target	36444635	hsa-mir-518a	Periodontal Diseases	CONCLUSION: Circ_0138960 promoted LPS-induced dysfunction in PDLCs by targeting miR-518a-5p/HDAC6 axis, which provided novel potential therapeutic targets for periodontitis.
genetics_GWAS	36444590	hsa-mir-423	Breast Neoplasms	The goal of this study was to determine if there was a link between the miR-423 rs6505162 gene variation and breast cancer susceptibility among Egyptian patients. CONCLUSION: Our data suggest that miR-423 rs6505162 polymorphism could be a potential risk factor in the pathogenesis of breast cancer among Egyptian population.
circRNA target	36444162	hsa-mir-1236	Osteosarcoma	CONCLUSION: Circ_0000253 promotes OS cell proliferation and suppresses cell apoptosis via regulating the miR
circRNA target	36443854	hsa-mir-667	Non-alcoholic Fatty Liver Disease	5p/SIRT1 axis reversed its effects, suggesting that targeting circLDLR/miR
other	36443711	hsa-mir-142	Breast Neoplasms	5p /RAC1/PAK1 axis.
genetics_overexpression_promote	36442661	hsa-mir-20b	Carcinoma, Hepatocellular	Mechanically, circITCH elevated PTEN expression to inactivate the PI3K/Akt signals through negatively regulating miR-20b-5p in HCC, and upregulating miR-20b-5p or inhibiting PTEN abolished the enhancing effect of circITCH overexpression on sorafenib-induced cytotoxicity in sorafenib-resistant HCC cells. CONCLUSION: Taken together, this study proves that circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells via regulating the miR-20b-5p/PTEN/PI3K/Akt signaling cascade, which highlights the potential value of circITCH as a target for enhancing the sorafenib-sensitivity in HCC.
transcription factor target	36442170	hsa-mir-1	Breast Neoplasms	ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells.
transcription factor target	36442170	hsa-mir-2	Breast Neoplasms	ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells.
genetics_knock down_promote	36441929	hsa-mir-140	Intracranial Aneurysm	Knockdown of miR-140 alleviates the development of intracranial aneurysms.
genetics_overexpression_suppress	36441170	hsa-mir-139	Urinary Bladder Neoplasms	Subsequent experimental results presented that overexpressing KIF18B could reverse inhibitory effect of overexpressing miRNA
genetics_overexpression_promote	36441004	hsa-mir-93	Urinary Bladder Neoplasms	Overexpression of PAFAH1B1 could efficiently reverse the effects of miR
other	36440973	hsa-mir-223	Complex Regional Pain Syndromes	In particular, microRNAs, such as miR-223, decreased in CRPS, have been described only in cross-sectional studies. CONCLUSION: We identified progressively reduced miR-223 as a putative biomarker of chronic CRPS pain.
transcription factor target	36440907	hsa-mir-124	Inflammatory Bowel Diseases	Collectively, Rauwolfia-derived PPs limited miR3p and targeted RBP4 and reduced the binding potency of RBP4 to NLRP3 to inhibit NLRP3-mediated pyroptosis, resulting in the alleviation of colonic epithelial cell pyroptosis and mucosal damages in UC.
genetics_overexpression_promote	36440854	hsa-mir-1	renal fibrosis	NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo.
other	36440749	hsa-mir-146a	Osteoarthritis	Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model.
other	36440749	hsa-mir-140	Osteoarthritis	Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model.
circulation_biomarker_diagnosis_ns	36440364	hsa-mir-146a	Arthritis, Rheumatoid	FLS were cocultured with WJR-containing serum to observe the effects of miRNA-146a-mediated autophagy via the PI3K/AKT/mTOR pathway on CIA-affected rats.
other	36440217	hsa-mir-21	Osteoporosis, Postmenopausal	Our findings suggest that whole-body vibration is a sufficient mechanical stimulus for altering c-miR5p expression, whereas a high intensity resistance exercise protocol did not elicit any c-miRNA responses in postmenopausal women.
other	36440215	hsa-mir-218	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-mir-517b	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-let-7a	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
other	36440215	hsa-mir-517a	Diabetes, Gestational	The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs.
lncRNA target	36440209	hsa-mir-107	Diabetes Mellitus, Type 1	CONCLUSION: Our results suggest that lncRNA such as lncRNA PVT1, LINC00960 and hsa-miR-107 might be involved in inflammation response in T1DM, and the former lncRNA chose in the present study may serve as novel biomarkers and potential targets for the diagnosis and treatment of T1DM.
target gene	36439901	hsa-mir-136	Uterine Cervical Neoplasms	Circular RNA circ_0004488 Increases Cervical Cancer Paclitaxel Resistance via the miR-136/MEX3C Signaling Pathway.
other	36439523	hsa-mir-550a	Adenocarcinoma of Lung	A nomogram consisting of BMI, history of chronic pain, miR 550a-3p, and VAS2d predicted the risk of CPSP after VATS in patients with lung adenocarcinoma.
other	36438900	hsa-mir-125b	Periodontitis	VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging.
other	36438900	hsa-mir-21	Periodontitis	VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging.
circulation_biomarker_diagnosis_up	36438898	hsa-mir-125b	Vitiligo	RESULTS: Compared with the healthy control group, the expression of miR-125b-5p in the tissues and serum of vitiligo patients was upregulated, and the expression of MITF was downregulated; compared with PIG1 cells, the expression of miR-125b-5p and MITF in the PIG3V group was consistent with the above.
transcription factor target	36438895	hsa-mir-877	Breast Neoplasms	5p inhibits epithelial mesenchymal transformation, cell proliferation, and invasion of BC cells via downregulating FGB.
circulation_biomarker_diagnosis_ns	36437340	hsa-mir-652	Pre-Eclampsia	3p, the level of SUMO 1-4 and UBC9 in the placenta, reduced concentration of PlGF, and increased sFlt-1/PlGF ratio in the blood of pregnant women with early-onset preeclampsia, which attests to the presence of a regulatory mechanism along the axis of miR
other	36437242	hsa-mir-17	skin melanoma	Seven immune-related CM prognostic molecules, including three mRNAs (SUCO, BTN3A1 and TBC1D2), three lncRNAs (HLA-DQB1-AS1, C9orf139 and C22orf34) and one miRNA (hsa-miR5p), were screened by differential expression analysis, ceRNA network analysis, LASSO Cox regression analysis and univariate Cox regression analysis.
genetics_knock down_promote	36436795	hsa-mir-1227	Osteoarthritis	3p inhibitor reversed the effect of circ_0114876 knockdown on the OA chondrocytes, and ADAM10 overexpression reversed the effect of miR
circulation_biomarker_diagnosis_down	36436490	hsa-mir-205	Kidney Diseases	Hence, our study sought to study the possible modulatory effect of rosuvastatin on miR-205 and its downstream target, Egl-9 family hypoxia-inducible factor 2 (EGLN2) to combat oxidative and endoplasmic reticulum (ER) stresses as pivotal contributors to colistin-associated renal injury.
transcription factor target	36436380	hsa-mir-129	Vitamin B Deficiency	These data indicates that miR3p affected ferroptosis under Se deficiency conditions through the SLC7A11 pathway.
genetics_overexpression_suppress	36436380	hsa-mir-129	Siderosis	3p/SLC7A11 axis could involve in the process of ferroptosis, our further research showed that overexpression of miR
other	36436380	hsa-mir-129	Deficiency Diseases	The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased.
other	36436380	hsa-mir-129	Liver Diseases	The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased.
lncRNA target	36436369	hsa-mir-223	Non-alcoholic Fatty Liver Disease	These results indicated that PAMK could relieve inflammatory liver tissue damage after LPS treatment and downregulate the level of inflammation factors via miR-223/NLRP3 axis, thus playing a liver protective role in liver inflammation injury in goslings.
transcription factor target	36436343	hsa-mir-338	Colorectal Neoplasms	3p, which may be a therapeutic target for CRC.
circRNA target	36436315	hsa-mir-506	Triple Negative Breast Neoplasms	3p was found to suppress proliferation and facilitate apoptosis of TNBC cells.
transcription factor target	36436291	hsa-mir-28	Otitis Media	Furthermore, in vivo experiments confirmed that CF-lenti-miR-28 inhibitor-Evs injection down-regulated the number of TRAP (+) MNCs and inhibited tooth movement of OTM rats.
genetics_knock down_promote	36436251	hsa-mir-204	Aortic Aneurysm, Abdominal	5p levels and reduced the expression of Mekk3, whereas lincRNA-p21 overexpression had the opposite effect.
other	36435921	hsa-mir-34a	Esophageal Squamous Cell Carcinoma	CONCLUSION: Our results not only provide evidence that HPV16 E6 promotes cell proliferation, migration, and invasion in ESCC, but also suggests a correlation between HPV infection and E6AP, p53 and miR-34a expression.
genetics_knock down_suppress	36435914	hsa-mir-140	Osteoarthritis	CONCLUSION: Circ_0136474 knockdown alleviated IL-1beta-triggered CHON-001 cell damage through modulation of miR3p/MECP2 axis, indicating a new target for treatment of OA.
other	36435866	hsa-mir-205	Carcinoma, Hepatocellular	CONCLUSION: Our data indicate that a LINC00152/miR5p/CXCL11 axis in HCC CAFs can affect the proliferative and migrative abilities of HCC cells in vitro and HCC tumor growth in vivo.
circulation_biomarker_diagnosis_up	36435781	hsa-mir-150	Lupus Erythematosus, Systemic	5p in peripheral blood mononuclear cells of SLE.
lncRNA target	36435763	hsa-mir-145	Femur Head Necrosis	In conclusion, miR-145 regulates the proliferation and differentiation of glucocorticoid-induced BMSC cells through GABARAPL1 and pharmacologically inhibit targeting miR-145 may provide new aspect for the treatment of SANFH.
lncRNA target	36435226	hsa-mir-370	Liver Cirrhosis	3p/Irak2 axis might be a novel identifier and therapeutic target for HF.
lncRNA target	36434857	hsa-mir-342	Brain Ischemia	5p on cerebral ischemia injury as well as novel targets for stroke.
circulation_biomarker_diagnosis_ns	36434610	hsa-mir-148a	Prostatic Neoplasms	Here, we investigated the correlation between the serum miR-148a-3p and miR5p expression levels and cancer recurrence in PCa patients, aiming to identify new biomarkers for diagnosis and predicting postoperative recurrence of prostate cancer.
circulation_biomarker_diagnosis_ns	36434610	hsa-mir-485	Prostatic Neoplasms	CONCLUSION: Pre-surgery serum miR-148a-3p level positively correlates while miR
lncRNA target	36434587	hsa-mir-101	Urinary Bladder Neoplasms	The promoting effects of NEAT1 on bladder cancer cells were reversed by miR-101 upregulation, and inhibition of miR-101 enhanced the effects of NEAT1.
other	36434577	hsa-mir-671	Lung Neoplasms	CONCLUSIONS: Elevated circ_0017109 expression promotes tumor progression of NSCLC by modulating miR5p/FZD4/beta-catenin axis.
circulation_biomarker_diagnosis_up	36434569	hsa-mir-15a	Primary Ovarian Insufficiency	RESULTS: miR-15a-5p was increased whilst Stat3 was decreased in the serum of POI patients and SS-induced KGN cells.
exosome	36434177	hsa-mir-375	Prostatic Neoplasms	In conclusion, our study suggests that cancer-derived exosomal miR-375 targets DIP2C, activates the Wnt signaling pathway, and promotes osteoblastic metastasis and PCa progression.
other	36433987	hsa-mir-124	Atherosclerosis	Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis.
other	36433987	hsa-mir-16	Atherosclerosis	Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis.
transcription factor target	36433652	hsa-mir-10b	Colorectal Neoplasms	The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues.
transcription factor target	36433652	hsa-mir-182	Colorectal Neoplasms	The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues.
circulation_biomarker_diagnosis_ns	36432575	hsa-mir-221	Diabetes Mellitus	We aimed to measure the adipose and plasma miR-221 and -222 levels, and to evaluate their association with adiposity, glucose intolerance, and new onset diabetes mellitus (NODM) after the commencement of PD. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
other	36432575	hsa-mir-221	Insulin Resistance	CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
circulation_biomarker_diagnosis_ns	36432575	hsa-mir-221	Obesity	Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin BACKGROUND: The correlation between microRNA, obesity, and glycemic intolerance in patients on peritoneal dialysis (PD) is unknown. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD.
circulation_biomarker_diagnosis_up	36432399	hsa-mir-103a	Diabetes, Gestational	The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR
circulation_biomarker_diagnosis_up	36432399	hsa-mir-222	Diabetes, Gestational	The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR
genetics_GWAS	36431040	hsa-mir-27a	Cardiovascular Diseases	Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls.
genetics_GWAS	36431040	hsa-mir-27a	Coronary Artery Disease	Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls.
lncRNA target	36430972	hsa-mir-29a	Tuberous Sclerosis	Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p).
lncRNA target	36430972	hsa-mir-33a	Tuberous Sclerosis	Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p).
lncRNA target	36430715	hsa-mir-169	Dehydration	The improved drought tolerance might be involved in the decreased expression levels of miRNA such as mtr_miR169l-5p, mtr_miR398b, and mtr_miR398c and its target genes in seedlings with active nodules. During severe drought stress, the lncRNA alternative splicings TCONS_00049507 and TCONS_00049510 competitively interacted with mtr_miR169l-5p, which upregulated the expression of NUCLEAR FACTOR-Y (NF-Y) transcription factor subfamily NF-YA genes MtNF-YA2 and MtNF-YA3 to regulate their downstream drought-response genes.
genetics_overexpression_promote	36430501	hsa-mir-408	Neutropenia, Severe Congenital, Autosomal Recessive 4	Overexpressing miR408 could negatively regulate soybean resistance to SCN by suppressing reactive oxygen species accumulation. Conversely, silencing miR408 positively regulates soybean resistance to SCN.
transcription factor target	36430468	hsa-mir-223	Rhabdomyosarcoma	Interestingly, IGF1R resulted in the direct target of miR-223 in AYA-RMS cells, as demonstrated by IGF1R silencing.
other	36430249	hsa-mir-369	Inflammatory Bowel Diseases	Our data suggest that miR3p may be a future alternative therapeutic approach to several compounds currently used for the treatment of inflammatory disorders including IBD.
lncRNA target	36430219	hsa-mir-592	Neuroblastoma	In conclusion, this study develops a lipid-metabolism-related gene-based prognostic model for NB and demonstrates that GDPD5 inhibits SH-SY5Y proliferation and migration and may be targeted by hsa-miR-592 and inhibit SH-SY5Y fat synthesis.
genetics_overexpression_promote	36430152	hsa-mir-515	Glioblastoma	TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies.
genetics_overexpression_promote	36430152	hsa-mir-126	Glioblastoma	TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies.
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-6851	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-8068	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-506	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
circulation_biomarker_diagnosis_ns	36428932	hsa-mir-144	Osteoporosis	Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR
other	36428476	hsa-mir-26a	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-186	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-210	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-205	Osteoarthritis, Knee	5p were detectable only in a few samples.
other	36428476	hsa-mir-199a	Osteoarthritis, Knee	5p were detectable only in a few samples.
transcription factor target	36427803	hsa-mir-615	Carcinoma, Non-Small-Cell Lung	In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR
transcription factor target	36427803	hsa-mir-744	Carcinoma, Non-Small-Cell Lung	In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR
epigenetics	36427628	hsa-mir-299	Insulin Resistance	5p-targeted resistin inhibition through demethylation, which underlies the mechanism of reducing IR.
epigenetics	36427628	hsa-mir-299	Myotonic Dystrophy	5p) expression was deficient in T2MD, which could be restored by aerobic exercise through modulating the DNA methylation modification enzymes.
other	36427609	hsa-mir-130b	Bone Diseases	The predicted circ_CUX1/miR-130b-5p/p300 axis might pave the way for better diagnostic and therapeutic approaches for bone-related diseases.
lncRNA target	36427469	hsa-mir-150	Endometriosis	CONCLUSION: MiR5p silencing inhibited hypoxia-induced autophagy and EMT of endometriotic cells by regulating the PDCD4/NF-kappaB signaling pathway.
other	36427432	hsa-mir-141	Pre-Eclampsia	Therefore, our data demonstrated that miR3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia.
other	36427432	hsa-mir-141	Pneumonia, Mycoplasma	3p), a multifunctional miRNA, is involved in a variety of physiological and pathological processes, including PE and autophagy.
other	36427432	hsa-mir-141	Hypoxia	3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia.
target gene	36426731	hsa-mir-337	Carcinoma, Non-Small-Cell Lung	Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3.
genetics_knock down_promote	36426627	hsa-mir-485	Breast Neoplasms	3p expression weakened the inhibiting effect of circ_0000129 knockdown on BC cell malignant behaviors.
genetics_overexpression_promote	36426595	hsa-mir-146a	Depressive Disorder, Major	CONCLUSIONS: The findings of this study reveal a relationship between miR-146a-5p overexpression and cortical atrophy and thus may help specify the in vivo mediating effect of miR-146a-5p dysregulation on brain structural abnormalities in patients with MDD.
circulation_biomarker_diagnosis_ns	36426578	hsa-mir-182	Triple Negative Breast Neoplasms	Finally, LNPs-miR3p were able to cross the blood-brain barrier and reduce intracranial tumors representing a possible therapeutic option for metastatic brain lesions.
lncRNA target	36426391	hsa-mir-150	Diabetes Mellitus, Type 2	5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19.
lncRNA target	36426391	hsa-mir-150	COVID-19	5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19.
other	36425259	hsa-mir-146a	Periodontal Diseases	Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation.
target gene	36424798	hsa-mir-374a	Stomach Neoplasms	Gastric cancer derived mesenchymal stem cells promote the migration of gastric cancer cells through miR-374a-5p.
circulation_biomarker_diagnosis_up	36424716	hsa-mir-184	Mucocutaneous Lymph Node Syndrome	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-19a	Mucocutaneous Lymph Node Syndrome	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-19a	limb ischemia	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
circulation_biomarker_diagnosis_up	36424716	hsa-mir-184	limb ischemia	Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA
genetics_knock down_promote	36424704	hsa-mir-202	Carcinoma, Endometrioid	5p depletion or CTNND1 overexpression, respectively.
exosome	36424471	hsa-mir-1228	Carcinoma, Hepatocellular	All in all, CAF-EV-carried miR
lncRNA target	36424455	hsa-mir-122	Acute Liver Injury	This study identifies a novel lncRNA with protective effects in acute liver injury and demonstrates that the binding of Mir122hg-C/EBPalpha promotes hepatocyte proliferation via upregulation of CXC chemokine and activation of AKT signaling.
exosome	36423858	hsa-mir-100	Endometriosis	Collectively, hUC-MSC-EV-loaded miR-100 downregulated HS3ST2 to facilitate the development of endometriosis, which highlights a promising therapeutic target for treating endometriosis.
genetics_overexpression_suppress	36423467	hsa-mir-203a	Elliptocytosis 2	These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways.
genetics_overexpression_suppress	36423467	hsa-mir-34b	Elliptocytosis 2	These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways.
transcription factor target	36423467	hsa-mir-203a	Abnormalities, Drug-Induced	When DEGs of miR-203a inhibitor-injected embryos were compared with BaP-exposed DEGs, alterations in nervous system development and function, and abnormal morphology of the neurosensory retina, eye and nervous tissue were predicted, consistent with both AhR and non-AhR pathways.
circulation_biomarker_diagnosis_ns	36423393	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	Significantly, accurate evaluation of miRNA-21 expression levels in cancer cell lines and non-small-cell lung carcinomas (NSCLC) serum samples are successfully achieved using the developed method.
lncRNA target	36423383	hsa-mir-146b	Thyroid Neoplasms	These findings support that targeting the LINC01311/miR-146b-5p/IMPA2 axis may be a promising approach against TC progression.
exosome	36423379	hsa-mir-24	Non-alcoholic Fatty Liver Disease	Collectively, our study demonstrated that MSCs-derived exosomal miR3p had hepaprotective effects through targeting Keap-1 signaling, providing a potential therapeutic value for NAFLD treatment.
lncRNA target	36422738	hsa-mir-1179	Stomach Neoplasms	Additionally, microRNA-1179 was found to play a key role in inhibiting the expression of ALDOA in the metabolic pathways of GC cells, which might disrupt the expression of various immune molecules and be detrimental to the prognosis of GC.
circulation_biomarker_diagnosis_up	36422510	hsa-mir-373	Alzheimer Disease	METHODS: The expression levels of miR-204 and miR-373 were investigated in neuron-derived serum exosomes obtained from 15 patients with mild AD, 18 with moderate AD, and 21 cognitively healthy individuals.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-33a	Liver Diseases	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-33a	Fatty Liver	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-200c	Liver Diseases	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
circulation_biomarker_diagnosis_up	36422507	hsa-mir-200c	Fatty Liver	It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c.
other	36421832	hsa-mir-1246	Pleural Effusion, Malignant	miRNA-1246 demonstrated 4-fold increased expression (OR: 3.87, 95% CI: 0.43, 35) in the MPE vs.
other	36421832	hsa-mir-150	Pleural Effusion, Malignant	HF-PE group and miR5p and miR-1246 in the BA-MPE vs.
other	36421385	hsa-mir-10a	Teratozoospermia	3p) did not significantly differ between the study and control groups.
genetics_knock down_promote	36420764	hsa-mir-1245b	Uterine Cervical Neoplasms	AATBC showed a significant prognostic value and miR-1245b-5p was found to mediate the tumor inhibitory effect of AATBC knockdown, which is speculated to be the underlying molecular mechanism of AATBC in cervical cancer development.
lncRNA target	36420706	hsa-mir-497	Breast Neoplasms	5p could improve the treatment response to paclitaxel in patients with breast cancer by inhibiting MALAT1 and SHOC2.
other	36420648	hsa-mir-146a	Arthritis, Rheumatoid	This study successfully predicted that LCK, FOXC1 and hsa-miR-146a-5p can be used as potential immune effector molecules of RA.
other	36420078	hsa-mir-455	Lung Neoplasms	LINC01635, a long non-coding RNA with a cancer/testis expression pattern, promotes lung cancer progression by sponging miR-455-5p.
circulation_biomarker_diagnosis_up	36419391	hsa-mir-367	Carcinoma, Non-Small-Cell Lung	3p in cancer tissues of 22 NSCLC patients was lower than corresponding normal tissues (P<0.05), and the serum miR
other	36419192	hsa-mir-342	Colitis, Ulcerative	3p-IRAK3 axes were found as potential regulatory pathways in UC.
other	36419192	hsa-mir-650	Colitis, Ulcerative	3p-IRAK3 axes were found as potential regulatory pathways in UC.
circulation_biomarker_diagnosis_ns	36418932	hsa-mir-124	Lupus Nephritis	RESULTS: HOXA11-OS was highly expressed in LN tissues, serum, and cells, and the expression of some key autophagy factors and Cyr61 was significantly increased, while miR
lncRNA target	36418889	hsa-mir-203	Ataxia Neuropathy Spectrum	Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2.
lncRNA target	36418889	hsa-mir-200	Cleft Palate	Thus, targeting of the ZEB2-miR-200 axis by TBX1 may have potential therapeutic implications in miRassociated tumors and cleft palate.
lncRNA target	36418889	hsa-mir-200	Ataxia Neuropathy Spectrum	Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2.
lncRNA target	36418889	hsa-mir-200b	Ataxia Neuropathy Spectrum	TBX1 rescues ZEB2-dependent transcriptional inhibition of the miR-200b/200a/429 cluster, whose promoter region contains conserved overlapping cis-regulatory motifs of the ZEB-binding E-box and TBX-binding element.
transcription factor target	36418472	hsa-mir-199	Melanoma, Experimental	5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance.
transcription factor target	36418472	hsa-mir-204	Melanoma, Experimental	5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance.
lncRNA target	36418471	hsa-mir-1231	Colorectal Neoplasms	Mechanistically, circTDRD3 promoted HIF1alpha expression by sponging miR-1231, which facilitated CRC progression. Our findings reveal that circTDRD3 facilitates the proliferation and metastasis of CRC through a positive feedback loop mediated by the HIF1alpha/PTBP1/circTDRD3/miR-1231/HIF1alpha axis.
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-23b	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-191	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
circulation_biomarker_diagnosis_ns	36418345	hsa-mir-92a	Breast Neoplasms	Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR
lncRNA target	36417821	hsa-mir-217	Acute Lung Injury	CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR
lncRNA target	36417821	hsa-mir-217	Sepsis	CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR
genetics_knock down_suppress	36417034	hsa-mir-214	Atrial Fibrillation	In conclusions, circCAMTA1 knockdown alleviated atrial fibrosis through downregulating TGFBR1 expression intermediated by miR
genetics_knock down_promote	36416408	hsa-mir-1225	Carcinoma, Non-Small-Cell Lung	5p recuperated the effects of circ_0075048 knockdown on NSCLC progression.
genetics_overexpression_promote	36416387	hsa-mir-23a	Pancreatic Carcinoma	HK-2 overexpression exerted oncogenic effects on pancreatic cancer cells and promoted cellular glycolysis; more importantly, HK-2 overexpression partially eliminated the effects of miR-323a overexpression.
other	36415802	hsa-mir-129	Myocardial Reperfusion Injury	5p.
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-373	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-21	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
circulation_biomarker_diagnosis_ns	36415626	hsa-mir-155	Breast Neoplasms	the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05)
genetics_knock down_promote	36415199	hsa-mir-181a	Osteosarcoma	However, knockdown miR-181a-5p promoted the proliferation and migration of osteosarcoma HOS cells, the cells in S phase increased(P<0.05).
lncRNA target	36414916	hsa-let-7c	Glioma	However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma.
other	36414911	hsa-mir-204	Depression	Notably, pre-ECT miR-204 levels moderately positively correlated with depression severity at baseline and moderately negatively correlated with mood score reduction post-ECT.
circulation_biomarker_diagnosis_ns	36414650	hsa-mir-144	COVID-19	Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR
other	36414609	hsa-mir-25	Hypertension	3p expression could aid HDIP diagnosis, and associated with an increased risk of adverse pregnancy outcomes in PE patients.
other	36414112	hsa-mir-34	Neurotic Disorders	RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype.
other	36414112	hsa-mir-34a	Neurotic Disorders	RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype.
transcription factor target	36414029	hsa-mir-122	Myocardial Infarction	The current study aims to investigate the cardioprotective effects of xanthenone through targeting the miR-122/Sirt-6/ACE2 axis on experimentally-induced MI in rats. Finally, by targeting the miR-122/Sirt-6/AMPK/ACE2 axis, xanthenone has the potential to be a promising cardioprotective agent against MI.
other	36413508	hsa-mir-24	Aortic Aneurysm, Abdominal	This study shows for the first time that inhaled e-cig nicotine vapor augments experimental AAA and aortic inflammation, suggests a mechanistic role for the cytokine Chil1/CHI3L1 and its regulator microRNA-24, and raises red flags regarding longitudinal e-cig safety.
transcription factor target	36413378	hsa-mir-382	Osteoarthritis	Our findings revealed that EVs produced by the OA rats contained miR5p, which might reduce cell viability and proliferation, and promote cell apoptosis by targeting PTEN.
circRNA target	36413177	hsa-mir-940	Keloid	CONCLUSIONS: This study suggests that hsa_circ_0038382 attenuates keloid formation by regulating the miR-940/TBX5 axis, which might provide a potential therapeutic target in the treatment of keloid formation.
genetics_knock down_promote	36412985	hsa-mir-133b	Esophageal Squamous Cell Carcinoma	NCK1-AS1 knockdown or miR-133b overexpression inhibited the malignant properties of ESCC cells as well as tumorigenesis in vivo.
circulation_biomarker_diagnosis_ns	36412588	hsa-mir-21	Breast Neoplasms	With the proposed method, the expression of miR-21 in different cancer cells can be assessed, and breast cancer patients and healthy individuals can be differentiated by analyzing the target miRNAs extracted from serum samples, holding great potential in clinical diagnosis.
transcription factor target	36412002	hsa-mir-21	Adenocarcinoma of Lung	QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro.
transcription factor target	36412002	hsa-mir-21	Carcinoma, Non-Small-Cell Lung	QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro.
circulation_biomarker_diagnosis_ns	36411886	hsa-mir-122	Carcinoma, Hepatocellular	Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin.
circulation_biomarker_diagnosis_ns	36411886	hsa-mir-122	Diabetes Mellitus, Type 2	Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin.
genetics_GWAS	36411728	hsa-mir-124-1	Zika virus congenital syndrome	We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR
genetics_GWAS	36411728	hsa-mir-124	Zika virus congenital syndrome	We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR
other	36411682	hsa-mir-145	Acute Kidney Injury	mediated autophagy.
other	36411682	hsa-mir-145	Reperfusion Injury	mediated autophagy.
lncRNA target	36411681	hsa-mir-200b	Liver Neoplasms	CONCLUSIONS: MiR-200b is involved in hepatocellular carcinoma progression via targeting SMYD2 and regulating SMYD2/p53/CyclinE1 signaling pathway and may be used as a potential target for hepatocellular carcinoma treatment.
other	36411517	hsa-mir-338	Prostatic Neoplasms	has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway.
genetics_GWAS	36411451	hsa-mir-218	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	Epigenetically, the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 expression was decreased in patients with CML. Furthermore, SLIT2 promoter methylation may function by regulating the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 during CML progression.
transcription factor target	36410437	hsa-mir-150	Prostatic Neoplasms	Additionally, profiling of MYB-targeted miRNAs demonstrated significant induction of miR-150 in high-dose androgen-treated PCa cells. Furthermore, MYB-silencing or miR-150 mimic transfection suppressed PCa cell growth induced by low-dose androgen, whereas miR-150 inhibition rescued PCa cells from growth repression by high-dose androgen.
other	36410410	hsa-mir-20b	Schizophrenia	SIGNIFICANCE: The significant SCZ-related ceRNAs subnetworks (lncRNA-C2orf48A/hsa-miR-20b-5p,5p/KIF23, FOXJ2) may represent promising predictive and diagnostic biomarkers and provide novel insights into the mechanism by which lncRNAs act as microRNA sponges and contribute to the pathogenesis of SCZ.
lncRNA target	36410171	hsa-mir-365a	Colorectal Neoplasms	RESULTS: In clinical samples and CRC cells, the abundance of HCG18 was enhanced whereas miR-365a-3p was reduced. CONCLUSION: Our results revealed that HCG18 promoted M2 macrophage polarization to facilitate CET resistance to CRC cells through modulating miR-365a-3p/FOXO1/CSF-1 axis.
other	36410106	hsa-mir-516b	Glioblastoma	Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G).
other	36410106	hsa-mir-516a	Glioblastoma	Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G).
transcription factor target	36410068	hsa-mir-375	Fatty Liver	This study uniquely revealed that miR-375 induced lipid synthesis and inhibited cell proliferation may partly due to regulation of RBPJ expression, thereby involving in fatty liver formation and inheritance in chicken.
circRNA target	36409529	hsa-mir-188	Pneumonia, Mycoplasma	3p, thereby inhibiting trophoblast cells function, which suggested a new molecular mechanism for the pathogenesis of PE.
exosome	36409397	hsa-mir-1	Adenocarcinoma of Lung	CONCLUSIONS: The promoting effect of IH on LUAD is achieved partly through BMSCs-derived exosomal miR
other	36408612	hsa-mir-454	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
other	36408612	hsa-mir-26b	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
other	36408612	hsa-mir-584	Osteoporosis	5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients.
lncRNA target	36408278	hsa-mir-155	Neurogenic Inflammation	Thus, BA suppressed the LPS-stimulated neuroinflammation in BV-2 microglia by blocking the TLR4-mediated signal transduction through TLR4/MyD88/NF-kappaB and MAPK pathways and inhibiting the miR-155 expression.
lncRNA target	36407085	hsa-mir-135b	Colonic Neoplasms	Moreover, the effects of hsa-miR-135b-5p on the biological behavior of COAD cells were observed. Therefore, downregulation of hsa-miR-135b-5p inhibits cell proliferation, migration, and invasion in COAD, and carcinogenesis may function by targeting FOXN2, NSA2, MYCBP, DIRAS2, DESI1, and RAB33B.
circulation_biomarker_diagnosis_ns	36406766	hsa-mir-182	Schizophrenia	On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis.
circulation_biomarker_diagnosis_ns	36406766	hsa-mir-183	Schizophrenia	On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis.
lncRNA target	36406317	hsa-mir-203a	Carcinoma, Hepatocellular	RESULTS: MiR-203a was significantly down-regulated in HBsAg-positive HCC with the sharpest decrease shown in microarray analysis. miR-203a may serve as a crucial treatment target in HBsAg-positive HCC.
lncRNA target	36406123	hsa-mir-190a	Ovarian Failure, Premature 	In conclusion, miRNA-190a-5p may become a potential biomarker for early screening of POF, and it can continuously activate primordial follicles in rats by targeting the expression of PHLPP1 and key proteins in the AKT-FOXO3a and AKT-LH/LHR pathways.
other	36406123	hsa-mir-151	Ovarian Failure, Premature 	5p.
other	36406123	hsa-mir-27b	Ovarian Failure, Premature 	5p.
other	36405735	hsa-mir-663a	Stomach Neoplasms	An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis.
other	36405735	hsa-mir-135a	Stomach Neoplasms	An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis.
transcription factor target	36405246	hsa-mir-524	Colonic Neoplasms	5p/CXCR7 axis regulated angiogenesis in colon cancer cells through the AKT and ERK pathways.
circulation_biomarker_diagnosis_down	36404826	hsa-mir-20a	Diabetes Mellitus, Type 2	METHODS: In the present study, we checked the expression of miR-320a, 182-5p, 503, and 375 by using quantitative PCR in both stimulated and unstimulated saliva and blood samples of 40 adult patients with type-2 diabetes compared to 40 healthy individuals.
genetics_knock down_promote	36404720	hsa-mir-885	Prostatic Neoplasms	5p, thereby blocking the effect of HOXA-AS2 knockdown by the miR
lncRNA target	36403772	hsa-mir-222	Prostatic Hyperplasia	Our findings elucidate that the pseudogene/lncRNA-hsa-miR3p-XBP1 pathway may play a regulatory role in the occurrence of BPH through autophagy.
lncRNA target	36403324	hsa-mir-29a	Tendon Injuries	Here, microRNA29a is identified as a promising therapeutic target for tendon injury through the cross-regulation of the immune response and matrix remodeling. In vivo studies of the Achilles tendon-rupture model indicate the best repair in the miR29a group, as evidenced by superior collagen composition and alignment, higher mechanical strength, and better functional recovery.
genetics_overexpression_suppress	36403222	hsa-mir-205	Influenza, Human	5p overexpression-induced inhibition of influenza A replication could be attributed to the inhibition of NP expression.
circRNA target	36403044	hsa-mir-27a	Hypertension, Pulmonary	CONCLUSION: Our findings demonstrated that circGSAP alleviated the dysfunction of PMECs via the increase of BMPR2 by competitively binding with miR-27a-3p, and mitigated pulmonary vascular remodeling of MCT-PH rats, providing potential therapeutic strategies for IPAH.
other	36401723	hsa-mir-217	Uterine Cervical Neoplasms	As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy.
other	36401723	hsa-mir-140	Uterine Cervical Neoplasms	As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy.
exosome	36401721	hsa-mir-506	Colorectal Neoplasms	The goal of the research was to study into the role of exosomal-miR
transcription factor target	36401720	hsa-mir-144	Necrobiotic Disorders	Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment.
transcription factor target	36401720	hsa-mir-144	Fibrosis	Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment.
other	36401685	hsa-mir-34a	Osteosarcoma	LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway.
other	36401491	hsa-mir-144	Urologic Neoplasms	Low miR-144 expression had better predictive value in patients with urinary system cancer (HR: 0.48, 95% CI: 0.35-0.64).
other	36401446	hsa-mir-34a	Pulmonary Disease, Chronic Obstructive	In conclusion, Res attenuated CSE-induced cellular senescence in BEAS-2B cells by regulating the miR-34a/SIRT1/NF-kappaB pathway, which may provide a new approach for COPD treatment.
genetics_GWAS	36401419	hsa-mir-146a	Coronary Disease	MicroRNA (miRNA)-146a rs2910164, a single nucleotide polymorphism, is associated with the progression of CHD risk.
lncRNA target	36401368	hsa-mir-200c	Breast Neoplasms	Collectively, baicalin significantly suppresses cell viability, migration, and invasion of BC cells possibly by regulating the TGF-beta/lncRNA-MALAT1/miR-200c pathway.
genetics_overexpression_promote	36401052	hsa-mir-421	Parkinson Disease	Overexpressed SNHG8 downregulates miR
lncRNA target	36400758	hsa-mir-202	Cholangiocarcinoma	Mechanistically, linc00976 competitively interacted with miR-3202 to upregulate GPX4 expression, thus contributing to the malignant biological behavior of CCA cells. Accordingly, JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating CCA tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis.
circulation_biomarker_diagnosis_up	36400592	hsa-mir-155	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
circulation_biomarker_diagnosis_up	36400592	hsa-mir-21	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
circulation_biomarker_diagnosis_up	36400592	hsa-mir-223	Neoplasm, Residual	"RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters."
lncRNA target	36399797	hsa-mir-485	Carcinoma, Ovarian Epithelial	CONCLUSION: SNHG17 silencing inhibits the development of EOC via regulation of miR
lncRNA target	36399659	hsa-mir-16b	Staphylococcal Infections	aureus-induced inflammation via microRNA-16b/YAP1-mediated regulation, and these findings might provide a new strategy for the prevention of bovine mastitis, facilitating further studies good of zoonotic diseases caused by S.
genetics_overexpression_promote	36399467	hsa-mir-34a	Melanoma	CONCLUSION: Melanoma cells overexpressed KCNQ1OT1, which influenced the miR-34a/STAT3 axis, to promote proliferation, migration, and invasion of melanoma cells.
transcription factor target	36399285	hsa-mir-106b	Leukemia, Myeloid	We also showed that inhibitors of the miR-106b-25 cluster and BCL-2 exert synergistic effects on apoptosis induction in primary myeloid leukaemic cells. Thus, the members of the miR-106b-25 cluster may jointly contribute to myeloid leukaemia drug resistance by inactivating multiple apoptotic genes.
other	36398728	hsa-mir-193a	Stomach Neoplasms	LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation.
other	36398319	hsa-mir-15b	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
other	36398319	hsa-mir-374a	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
other	36398319	hsa-mir-106a	Neoplasm, Residual	Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions.
exosome	36398229	hsa-mir-665	Osteosarcoma	CONCLUSION: This work proved that exosomes loaded with miR-665 inhibited the progression of OS in vivo and in vitro in a safe manner.
exosome	36398226	hsa-mir-382	Sepsis	CONCLUSION: EPC-derived exosomal miR
other	36398070	hsa-mir-200b	Pterygium	The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs.
other	36398070	hsa-mir-1	Pterygium	We found that hsa_circ_0002406 might upregulate FN1 and ADAM12 by sponging miR-26b-5p and miR3p, respectively, thus promoting EMT in pterygium.
other	36398070	hsa-mir-203a	Pterygium	The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs.
other	36398067	hsa-mir-148a	Carcinoma, Hepatocellular	In general, our data provided evidence that HCG18/hsa-mir-148a-regulated high expression of LAYN is associated with immune cell infiltration and unfavorable prognosis of LIHC patients.
lncRNA target	36397699	hsa-mir-361	Hyalinosis, Systemic	CONCLUSION: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m6A-dependent manner through miR
lncRNA target	36397308	hsa-mir-1272	Colorectal Neoplasms	CONCLUSION: Circ_0006508-mediated miR-1272 inhibition could promote the malignant behaviors of colorectal cancer with an upregulated Warburg effect.
other	36397164	hsa-mir-1208	Glioblastoma	The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression.
transcription factor target	36396820	hsa-mir-361	Colorectal Neoplasms	nucleatum-infected CRC via the MYC/miR5p/sonic hedgehog pathway cascade, subsequently reversing stemness and abolishing F.
exosome	36396777	hsa-mir-376c	Osteoarthritis	Meanwhile, the in vivo experiments also corroborated that the miR-376c-3p in hADSC-derived Exos mitigated OA-induced chondrocyte degradation and synovial fibrosis. MiR-376c-3p in hADSC-derived Exos repressed the WNT-beta-catenin pathway by targeting WNT3 or WNT9a, and then mitigating OA-induced chondrocyte degradation and synovial fibrosis, thereby providing theoretical basis for clinical implementation of treatment.
genetics_knock down_promote	36396668	hsa-mir-548l	Neuroblastoma	We also found that miR-548l overexpression suppressed cell viability and promoted apoptosis, while miR-548l knockdown promoted cell viability and inhibited apoptosis in neuroblastoma cells.
transcription factor target	36396627	hsa-mir-760	Urinary Bladder Neoplasms	Together, we concluded a regulatory axis composed of METTL1/m(7)G/miR-760/ATF3 in regulating BCa progression and provided potential therapeutic targets for BCa.
exosome	36396626	hsa-mir-769	Oculodigitoesophagoduodenal syndrome	5p to be loaded into extracellular vesicles (EVs) and to promote MMT reversal in recipient mesenchymal-like MCs.
other	36396626	hsa-mir-769	Fibrosis	In conclusion, we highlighted an HDAC1-WT1-miR5p axis potentially relevant for therapies aimed at counteracting organ fibrosis.
genetics_knock down_promote	36396591	hsa-mir-1297	salivary gland adenoid cystic carcinoma	STUDY DESIGN: The expression of long non-coding RNA human leukocyte antigen complex group 11 (HCG11), microRNA-1297 (miR-1297), and EphA2 in SACC cell lines compared with normal human salivary gland (HSG) cell line was measured by reverse transcription-quantitative polymerase chain reaction.
other	36396240	hsa-mir-141	Prostatic Neoplasms	The latest research shows that the expression level of microRNA-141 can predict the number of prostate cancer cells in the human body and has become an important biomarker. In this paper, an all-carbon sandwich self-powered biosensor based on graphene and carbon cloth is constructed for the highly sensitive detection of the prostate tumor marker miRNA-141.
other	36394782	hsa-mir-1246	Breast Neoplasms	MiR-1246 has recently gained much attention and many studies have shown its oncogenic role in colorectal, breast, lung, and ovarian cancers.
genetics_overexpression_promote	36394255	hsa-mir-326	Thyroid Cancer, Papillary	Additionally, miR-326 was a downstream target of circ_0003892, and miR-326 overexpression weakened the promoting effect of circ_0003892 overexpression on the malignant progression of PTC.
other	36394070	hsa-mir-148a	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394070	hsa-mir-486	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394070	hsa-mir-744	Sleep Apnea, Obstructive	5p + 1.13  let-7d-3p.
other	36394065	hsa-mir-142	Adenocarcinoma of Lung	3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients.
other	36389659	hsa-mir-146	Neurogenic Inflammation	Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation.
other	36389659	hsa-mir-146a	Neurogenic Inflammation	Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation.
genetics_knock down_promote	36389659	hsa-mir-146b	Neurogenic Inflammation	Our experiments demonstrated that miR-146b deficiency results in the attenuation of LPS-induced neuroinflammation, as it was evidenced by the reduction of sickness behavior, a decrease in the inflammatory status of microglia, and the loss of morphological signs of microglial activation in the hippocampus.
lncRNA target	36389338	hsa-mir-491	Carcinoma, Non-Small-Cell Lung	CONCLUSIONS: LncRNA KCNQ1OT1 was associated with the radioresistance of radioresistant LUSC cells, and the lncRNA KCNQ1OT1/miR5p/TPX2-RNF2 axis might be used as a therapeutic target to enhance the radiosensitivity of radioresistant LUSC cells.
transcription factor target	36389185	hsa-mir-29a	Tuberculosis, Pulmonary	The upregulation of miRNA-29a-3p suppresses the immune response by post-transcriptionally inhibiting interferon (INF)- expression in T cells, increasing susceptibility to pulmonary TB.
tissue_expression_ns	36388982	hsa-mir-17	Thymic aplasia	We demonstrate that transgenic miR-17 approximately 92 cell-intrinsically largely overcomes defects caused by CD28 deficiency.
other	36388689	hsa-mir-200b	Stomach Neoplasms	Interfering HMGB3 release from cancer-associated fibroblasts by miR-200b represses chemoresistance and epithelial-mesenchymal transition of gastric cancer cells.
circulation_biomarker_prognosis_down	36388649	hsa-mir-375	Esophageal Squamous Cell Carcinoma	RESULTS: miR-375 expression was significantly downregulated in both ESCC clinical tissues and serum, and the reduction of miR-375 was remarkably linked to a poor prognosis in ESCC.
exosome	36388165	hsa-mir-4455	Glomerulonephritis, IGA	This study revealed that MC-derived exosomal miR-4455 is a key factor affecting podocyte injury and provides a series of potential therapeutic targets for treating IgA nephropathy.
target gene	36388045	hsa-mir-137	Carcinoma, Non-Small-Cell Lung	miR-137 represses migration and cell motility by targeting COX-2 in non-small cell lung cancer.
other	36387469	hsa-mir-21	Adenocarcinoma of Lung	Finally, we discovered that the lncRNA MIR17HG/AC009299.3/miR5p/CCL20 regulatory network might be crucial in the pathogenesis of LUAD.
epigenetics	36387263	hsa-mir-1	Prostatic Neoplasms	3p expression by promoter hypermethylation.
lncRNA target	36387210	hsa-mir-628	Triple Negative Breast Neoplasms	This study demonstrated the vital roles of WFDC21P and its m6A in regulating the proliferation and metastasis of TNBC cells via the WFDC21P/miR-628/SMAD3 axis.
target gene	36387162	hsa-mir-134	Melanoma	Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma.
lncRNA target	36387061	hsa-mir-1249	Osteosarcoma	CONCLUSIONS: Our study uncovered the cancer-promoting role of LINC00665 in OS, and the feedback loop of LINC00665/miR5p/WNT2B/Wnt might be a potential target for OS treatment.
circulation_biomarker_prognosis_up	36386576	hsa-mir-10a	Pneumonia	RESULTS: Compared with healthy control, serum miR-10a-3p expression in patients with severe pneumonia was distinctly upregulated (P < 0.001).
other	36385489	hsa-mir-875	Carcinoma, Hepatocellular	YY1-activated LINC01608 could promote HCC progression by associating with miR5p to induce the EGFR/ERK signalling pathway.
other	36385302	hsa-mir-218	Alopecia	miR-218 has therapeutic potential for alopecia since it can activate the Wnt/beta-catenin channel by down-regulating SFRP2, which is a key channel in hair follicle cycle transformation for hair regrowth.
lncRNA target	36385135	hsa-mir-574	Colorectal Neoplasms	Our results suggested that NALT1 promoted CRC proliferation and migration by sponging miRNA5p to upregulate PEG10 expression, and implied that NALT1 might act as a promising biomarker and therapeutic target for CRC.
lncRNA target	36384413	hsa-mir-29c	Nerve Degeneration	SNHG15 served as a sponge to down-regulate miR-29c-3p, thereby releasing the inhibition of miR-29c-3p on SNCA expression, which promoted neuronal damages upon MPP(+) challenge. CONCLUSION: The upregulation of SNHG15 upon MPP(+) challenge mediates neuronal damages in SK-N-SH cells by regulating miR-29c-3p/SNCA axis.
lncRNA target	36384265	hsa-mir-214	Cardiomyopathies	3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis.
lncRNA target	36384265	hsa-mir-214	Sepsis	3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis.
transcription factor target	36384170	hsa-mir-155-1	Distal myopathy, Nonaka type	1 could act as a positive factor for virus replication in DEFs, which inhibited type I interferon (IFN-I) production.
genetics_overexpression_suppress	36384115	hsa-mir-145	Sucrase-isomaltase deficiency, congenital	5p overexpression.
other	36383327	hsa-mir-744	Multiple Sclerosis	5p is recommended as an important biomarker for the development together of diabetes mellitus, Alzheimer's disease, and MS disease.
circRNA target	36382967	hsa-mir-584	Carcinoma, Non-Small-Cell Lung	CONCLUSION: Circ_0079530 promoted NSCLC progression by regulating the miR5p/THBS2 axis, providing a possible circRNA-targeted therapy for NSCLC.
lncRNA target	36382488	hsa-mir-137	Glioma	CONCLUSIONS: It was found that miR-137 could target E2F7 to restrain cell progression and accelerate programmed cell death of glioma cells, which is helpful to search for new molecular therapeutic targets for glioma.
lncRNA target	36382487	hsa-mir-27b	Glioma	CONCLUSIONS: Silencing LINC01128 inhibited the proliferation, migration, and invasion levels of glioma cells by targeting miR-27b-3p, thereby affecting the progression of gliomas.
lncRNA target	36381992	hsa-mir-92b	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381992	hsa-mir-374b	Pulmonary Disease, Chronic Obstructive	RESULTS: One miRNA was significantly dysregulated between moderate GOLD participants compared to severe/very severe GOLD participants, with an AUC of 0.798, p = 0.01 for miR-374b-5p.
lncRNA target	36381992	hsa-mir-223	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381992	hsa-mir-374a	Pulmonary Disease, Chronic Obstructive	Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001).
lncRNA target	36381675	hsa-mir-27a	Colonic Neoplasms	CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU.
lncRNA target	36381675	hsa-mir-27	Colonic Neoplasms	CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU.
other	36381642	hsa-mir-595	Coronary Artery Disease	In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression.
other	36381642	hsa-mir-24	Coronary Artery Disease	In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression.
lncRNA target	36381585	hsa-mir-142a	Peripheral Nerve Injuries	Together, these results suggest that miR-142a-3p may be a potential target for therapeutic intervention to prevent motor endplate degradation following peripheral nerve injury.
target gene	36381334	hsa-mir-122	Prostatic Neoplasms	MicroRNA-122 targets delta-catenin to suppress the tumorigenic potential of prostate cancer cells.
genetics_GWAS	36381329	hsa-mir-99b	Breast Neoplasms	MiR-99b-high breast cancer was associated with high homologous recombination deficiencies, intratumor heterogeneity, and high rates of mutation and neoantigens.
genetics_GWAS	36381083	hsa-mir-217	Retinoblastoma	3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001).
genetics_GWAS	36381083	hsa-mir-592	Retinoblastoma	3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001).
other	36380872	hsa-mir-369	Thyroid Neoplasms	lncRNA EGFEM1P promotes thyroid cancer progression by acting as an miR-369-3p sponge and upregulating TCF4.
genetics_knock down_promote	36380666	hsa-mir-38	Nasopharyngeal Carcinoma	3p targeted and negatively regulated ELAVL1; ELAVL1 overexpression affected the effects of miR
lncRNA target	36380665	hsa-mir-21	Colorectal Neoplasms	Methods: The colorectal carcinoma (CRC) cell HCT116 was divided into blank control, negative control (NC), si-GAS5 and si-GAS5+ miR-21 inhibitor groups. Conclusion: GAS5 can act as a competing endogenous RNA for miR-21, and down regulation of GAS5 can promote the development of CRC by activating the miR-21/PTEN/Akt signaling pathway and promoting the acquisition of EMT and tumor cell stemness.
other	36380664	hsa-mir-503	Esophageal Squamous Cell Carcinoma	The xenograft experiment showed that the subcutaneous tumor in shMIR503HG group was significantly smaller than that in shNC group, and the tumor weight in shMIR503HG group was (0.097+/-0.026) g, which was lower than (0.166+/-0.021) g in shNC group (P<0.001).
circulation_biomarker_diagnosis_ns	36380587	hsa-mir-126	Neoplasms, Vascular Tissue	In a validated experimental model of lethal murine vascular neoplasm, tumor-originating EV delivered its miR-126 cargo to tumor-associated macrophages (TAMs).
genetics_overexpression_promote	36380260	hsa-mir-125b	Carcinoma, Endometrioid	Besides, the promoting impact of MTFP1 overexpression on malignant phenotypes of EC cells could be restored by miR-125b-5p up-regulation.
circRNA target	36380035	hsa-mir-873	Carcinoma, Hepatocellular	5p directly targeted the 3' untranslated region (3'UTR) of PHF2, and PHF2 was negatively regulated by miR
lncRNA target	36379611	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	In our previous work, we reported that the targeted expression of microRNA-7 (miR-7) operated by thyroid transcription factor-1 (TTF-1) promoter inhibited the growth of human lung cancer cells in vitro and in vivo; however, the intervention efficiency needed to be further improved. On the whole, our study revealed that the optimized TTF-1 promoter could more effectively operate miR-7 to influence the growth of human NSCLC cells, providing a new basis for the development of microRNA-based targeting gene therapy against clinical lung cancer.
other	36379393	hsa-mir-146a	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379393	hsa-mir-23a	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379393	hsa-mir-652	Osteoarthritis	Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain.
other	36379214	hsa-mir-124	Bipolar Disorder	3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP.
other	36379214	hsa-mir-124	Schizophrenia	3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP.
other	36378391	hsa-mir-488	Epilepsy	LncRNA PVT1 Promotes Neuronal Cell Apoptosis and Neuroinflammation by Regulating miR-488-3p/FOXD3/SCN2A Axis in Epilepsy.
other	36378340	hsa-mir-1914	Ovarian Neoplasms	We hypothesize that mir-1914 might open a new line of research in the realm of managing the recurrence of OC and could be a significant factor in triggering OC recurrence.
genetics_overexpression_promote	36377304	hsa-mir-199b	Carcinoma, Hepatocellular	Overexpressed miR-199b-3p constrained HCC cell proliferation, migration, and invasion while fostering apoptosis, which could be counteracted by upregulating AURKA.
other	36377220	hsa-mir-503	Endometriosis	Poly lactic-co-glycolic-based NPs were used as vector carriers for miRNA 503 transfection in endometriosis cells.
transcription factor target	36377217	hsa-mir-140	Pneumonia	CONCLUSION: In ASMCs, miR3p can inhibit the JAK2/STAT3 signaling pathway by targeting HMGB1, thus ameliorating airway inflammation and remodeling in the pathogenesis of asthma.
circulation_biomarker_diagnosis_ns	36377217	hsa-mir-140	Asthma	3p expression was declined in asthmatic patients' plasma and ASMCs stimulated by PDGF-BB.
lncRNA target	36377216	hsa-mir-18a	Colorectal Neoplasms	CONCLUSION: CASC2 inhibits CRC development by suppressing miR-18a-5p and raising BTG3 expression.
other	36376850	hsa-mir-509	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-421	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-769	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-42	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-296	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-193a	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-139	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
other	36376850	hsa-mir-767	Carcinoma, Hepatocellular	3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients.
lncRNA target	36376845	hsa-mir-340	Liver Cirrhosis, Hepatitis Virus B-Related	5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC.
lncRNA target	36376845	hsa-mir-20a	Liver Cirrhosis, Hepatitis Virus B-Related	5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC.
epigenetics	36376550	hsa-mir-29c	Lung Neoplasms	CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis.
other	36375570	hsa-mir-145	Breast Neoplasms	KEY FINDINGS: Based on bioinformatics analyses, CCAT2, AKT3, and mTOR were up-regulated in breast cancer cell lines, tissues, and TAM-resistant cells, while hsa-miR5p was down-regulated.
transcription factor target	36375474	hsa-mir-570	Colorectal Neoplasms	CONCLUSIONS: The present study reveals that ZnC slows the progression of CRC by inhibiting CRC cells in terms of proliferation, invasion and migration, meanwhile up-regulating PD-L1 expression via inhibiting miR-570.
virus_miRNA	36374933	bkv-mir-B1	Kidney Transplantation	Urine exosomal bkv-miR-B1-5p was associated with BKVN as were urine and plasma BKV DNA loads on serial follow-up, and might have potential as a predictive marker for BKVN during the early post-transplant period.
lncRNA target	36374810	hsa-mir-3677	Uterine Cervical Neoplasms	TRAF3IP2-AS1 may play a tumor-suppressor role in cervical cancer progression by sponging miR
other	36374808	hsa-mir-148b	Carotid Stenosis	Pearson analysis was used to analyze the relationship between HOTAIR and miR-148b-3p in patients with CAS. Reduction of miR-148b-3p expression was substantiated in CAS patients.
other	36374807	hsa-mir-130a	Thyroid Neoplasms	TYMSOS and myristoylated alanine rich protein kinase C substrate like 1 (MARCKSL1) were upregulated whereas miR-130a-5p was downregulated in THCA cells and tissues. Collectively, TYMSOS facilitates THCA progression by sponging miR-130a-5p and upregulating MARCKSL1 to activate the PI3K/Akt signaling pathway, providing new avenues for THCA treatment.
transcription factor target	36374798	hsa-mir-424	Carcinoma, Hepatocellular	Therefore, ultrasound-mediated targeted NBs are a potential effective carrier for liver cancer, and PD-L1 antibody and miR-424 have a synergistic anti-tumor immunotherapy effect.
other	36374774	hsa-mir-32	Colorectal Neoplasms	Meanwhile, we found that the transcription factor SP1 activated PROX1-AS1/miR-32/FBXL20 axis, thereby promoting CRC progression.
other	36374443	hsa-mir-497	Urinary Bladder Neoplasms	RESULTS: CEP55 expression as well as the expression levels of the oncogenic proteins PTHLH and HMGA2 were upregulated in BC cells while miR5p was downregulated.
genetics_GWAS	36374407	hsa-mir-495	Large-Artery   Atherosclerosis Stroke	MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.
genetics_GWAS	36374407	hsa-mir-200b	Large-Artery   Atherosclerosis Stroke	MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population.
transcription factor target	36374403	hsa-mir-23a	Colonic Neoplasms	This study demonstrated the mechanism of miR-23a-3p in CC, which may offer a new target for CC therapy.
other	36374119	hsa-mir-143	Urinary Bladder Neoplasms	Besides, miR-143 is a promising candidate biomarker for diagnosing BCa.
lncRNA target	36372373	hsa-mir-140	Ischemic Stroke	3p directly targets Tyro3 to regulate cell viability and apoptosis of OGD/R-exposed N2a cells through the PI3K/Akt pathway, suggesting that miR
genetics_knock down_promote	36371782	hsa-mir-1294	Stomach Neoplasms	RESULTS: The levels of hsa_circ_0043691 and PBX3 were upregulated, whereas miR-1294 expression was diminished in GC tissues and cells. CONCLUSION: Hsa_circ_0043691 knockdown repressed GC malignant phenotypes by miR-1294/PBX3 axis, which exhibited a novel therapeutic target for GC treatment.
other	36371775	hsa-mir-4739	Adenocarcinoma of Lung	RESULTS: The expression levels of LINC00511 and PYCR1 in LUAD were downregulated, whereas that of miR-4739 was upregulated. CONCLUSION: This study demonstrates for the first time that LINC00511 aggravates the malignancy of LUAD by sponging miR-4739 to upregulate PYCR1 expression.
genetics_GWAS	36371555	hsa-mir-149	Breast Neoplasms	Therefore, human blood samples and breast cancer cell line (MCF7) were analyzed to study any possible association between the genetic variant (rs2292832) in the miR-149 precursor and breast cancer susceptibility. METHODS: To study the role of rs2292832 polymorphism in breast cancer, the miR-149 gene variant was genotyped using PCR-RFLP.
lncRNA target	36371491	hsa-mir-195	Triple Negative Breast Neoplasms	5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application.
genetics_knock down_suppress	36371182	hsa-mir-127	Breast Neoplasms	The knockdown of miR-127 substantially increased, whereas overexpression decreased BC cell proliferation, invasion, and migration.
other	36370665	hsa-mir-326	Colorectal Neoplasms	5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC.
other	36370665	hsa-mir-30	Colorectal Neoplasms	5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC.
lncRNA target	36370637	hsa-mir-146a	Rhinitis, Allergic	Treatment with ESP-B4 relieved AR in rats, and elevated miR-146a-5p in the EVs from the nasal epithelial cells, apparently in relation to effects on helper T cell Th1/Th2 equilibrium. CONCLUSION: Overall, ESP-B4 can promote miR-146a-5p secretion, affect the Th1/Th2 balance of helper T cells, and relieve AR symptoms through Smad3/GATA-3 interaction, thus presenting a potential strategy for AR treatment.
transcription factor target	36370225	hsa-mir-200a	Memory Disorders	Our findings imply that miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for treating T2DM-induced memory dysfunction.
lncRNA target	36369960	hsa-mir-493	Cholangiocarcinoma	5p in EVs.
genetics_overexpression_suppress	36369900	hsa-mir-135b	Ovarian Neoplasms	Circ_0000471 served as a molecular sponge for microRNA-135b-5p (miR-135b-5p), and circ_0000471 overexpression-mediated anti-tumor influences in OC cells were largely reversed by the overexpression of miR-135b-5p.
other	36369887	hsa-mir-99a	Osteoporosis	Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication.
other	36369887	hsa-mir-99a	Osteoporosis-pseudoglioma syndrome	Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication.
circulation_biomarker_diagnosis_up	36369742	hsa-mir-210	Disorders of Sex Development	CONCLUSION: Our study showed a positive association between the presence of atypical genitalia and plasma levels of miR-210 expression in the group of patients with 46,XY DSD of unknown aetiology studied.
other	36369467	hsa-mir-654	Pancreatic Carcinoma	Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR3p sponge, thus promoting the PC malignant process.
circulation_biomarker_diagnosis_up	36369428	hsa-mir-19b	Hypoxia-Ischemia, Brain	The expression of miR-19b-3p and SOX6 in umbilical blood of HIE patients was detected by qRT-PCR assay. MiR-19b-3p expression was once down-regulated, whilst SOX6 expression was up-regulated in HIE patients.
lncRNA target	36368448	hsa-mir-363	Pre-Eclampsia	Furthermore, in vivo experiments noted that RES alleviated placental injury and promoted angiogenesis in rats with PE-like symptoms in vivo by increasing VEGF via promoting miR
lncRNA target	36368065	hsa-mir-144	Myocardial Infarction	After intervening the expression of miR-144 by microinjecting and activating Wnt pathway by an agonist BML-284, we confirmed that up-regulated miR-144 suppressed the expression of angiogenesis-related genes and negatively regulated Wnt pathway, further triggering angiogenesis disorders and cardiac phenotypic malformation.
other	36367679	hsa-mir-34a	Cognition Disorders	"The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4."
other	36367679	hsa-mir-128	Cognition Disorders	"The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4."
lncRNA target	36367621	hsa-mir-17	Colonic Neoplasms	3p regulated CC cell malignant progression, as well as apoptosis by targeting PLCD1.
lncRNA target	36367475	hsa-mir-125b	Ischemic Stroke	MSC-EVs inhibit astrocyte activation and associated inflammation through miR-125b-5p/TLR4/NF-kappaB pathway.
lncRNA target	36366842	hsa-mir-6938	Stomach Neoplasms	CONCLUSION: Taken together, our findings demonstrated that circSNTB2 plays an essential role in gastric cancer by regulating miR5p through G0S2 and PDCD4 genes.
lncRNA target	36366818	hsa-mir-3682	Carcinoma, Hepatocellular	In addition, inhibition of PTEN weakened the anti-migration and anti-stemnesic effects of miR
target gene	36366788	hsa-mir-151a	Colorectal Neoplasms	miR-30d-5p and miR-151a-3p, altered in CRC tissue, were also dysregulated in stool of CRC patients and urine of BC cases, respectively.
other	36366542	hsa-let-7f	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-126	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-let-7a	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-122	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36366542	hsa-mir-101	Asthma	3p, were identified between asthmatic and healthy subjects after inoculation with RV.
other	36362375	hsa-mir-101	Carcinoma, Hepatocellular	3p/TKTL1) associated with the progression of HCC under hypoxia.
lncRNA target	36361993	hsa-mir-34a	Colorectal Neoplasms	In conclusion, RF-EMF strongly influenced regulation mediated by the tumour suppressor miR-34a on the peripheral circadian oscillator in DLD1 cells.
lncRNA target	36361979	hsa-mir-1	Fibrosis	5p show the potential to inhibit LEC-dependent fibrosis.
genetics_knock down_suppress	36361843	hsa-mir-143	Obesity	Importantly, during high fat diet-induced obesity, miR-143KO significantly reduced body weight, and improved energy expenditure, insulin sensitivity, and glucose tolerance.
other	36361623	hsa-mir-223	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-21	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-128	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-92a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-92a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-21	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-142	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-26a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-15a	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-128	Sexual Dysfunctions, Psychological	3p and miR-26a-5p.
other	36361623	hsa-mir-142	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-26a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-15a	Genital Diseases, Female	3p and miR-26a-5p.
other	36361623	hsa-mir-223	Genital Diseases, Female	3p and miR-26a-5p.
other	36360309	hsa-mir-1255b	Diabetes Mellitus, Type 2	SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation.
other	36360309	hsa-mir-548o	Diabetes Mellitus, Type 2	SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation.
other	36360258	hsa-mir-203b	Food Hypersensitivity	Logistical regression models revealed that the addition of multi-omic features (miR-203b-3p, Cyanobacteria, and Proteus virus PM135) improved predictiveness for future FRs in infants (p = 0.005, X(2) = 12.9), predicting FRs with 72% accuracy (AUC = 0.81, sensitivity = 72%, specificity = 72%).
transcription factor target	36360255	hsa-mir-431	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-487b	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-432	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-127	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-134	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-23b	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-485	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-382	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-493	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-369	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-34c	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36360255	hsa-mir-122	Premature Birth	Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR
transcription factor target	36359915	hsa-mir-199a	Mastitis	Despite its importance in humans and animals, the molecular mechanism of bovine miR-199a-3p (bta-miR-199a-3p) in dairy cow mastitis and bovine mammary epithelial cell (bMEC) inflammation is unclear. This study reveals the potential regulatory mechanism of bta-miR-199a-3p in bMEC inflammatory immune response and may serve as a useful target for the treatment of mastitis.
lncRNA target	36359915	hsa-mir-199a	Inflammation	Thus, bta-miR-199a-3p inhibits LPS-induced inflammation in bMECs by directly targeting CD2AP and regulating the PI3K/AKT/NF-kappaB signaling pathway.
lncRNA target	36359873	hsa-mir-1264	Chondrosarcoma	Our results indicate that visfatin inhibits miR-1264 production through the PI3K/Akt/mTOR signaling cascade, and thereby promotes PDGF-C expression and chondrosarcoma angiogenesis.
lncRNA target	36359865	hsa-mir-374	Hepatocellular Carcinoma, Hbv-Related	5p/FOXO1 pathway were significantly dysregulated in HCC, and validation in vitro showed that FOXO1 is positively regulated by MAGI2-AS3 through the induction of miR-374a/b-5p in HCC cells.
transcription factor target	36359857	hsa-mir-397	Hepatolenticular Degeneration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-397	Dehydration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-408	Dehydration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
transcription factor target	36359857	hsa-mir-408	Hepatolenticular Degeneration	MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes.
exosome	36359855	hsa-mir-140	Diabetes, Gestational	These findings indicate that chemerin reduces placenta-derived exosomal miR
exosome	36359855	hsa-mir-574	Diabetes, Gestational	These findings indicate that chemerin reduces placenta-derived exosomal miR
genetics_overexpression_promote	36359774	hsa-mir-21	Alzheimer Disease	In AD neurons, miR-124/miR-21 overexpression was recapitulated in their exosomes.
circulation_biomarker_diagnosis_ns	36359344	hsa-mir-125b	Hepatitis B, Chronic	This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV).
circulation_biomarker_diagnosis_ns	36359344	hsa-mir-125	Hepatitis B, Chronic	This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV).
other	36358979	hsa-mir-122	Hepatitis C	By complementing miR-122 at the 5' end of the genome, the hepatitis C virus (HCV) gene can form a complex with Argonaute 2 (Ago2) protein to protect the 5' end of HCV RNA from exonucleolytic attacks.
lncRNA target	36357766	hsa-mir-217	Breast Neoplasms	miR-217 repressed sensitivity against anti-cancer drugs by inducing autophagy of BC cells through the NF1/HSF1/ATG7 axis.
lncRNA target	36357715	hsa-mir-125b	Alzheimer Disease 	Altogether, these results indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.
other	36357650	hsa-mir-1225	Uterine Cervical Neoplasms	Collectively, the present study indicates that hsa_circ_0001627 regulates miR5p/FNDC3B/PI3K/mTOR axis and functions as an oncogene in CC progression, suggesting the potential therapeutic use of hsa_circ_0001627 in CC treatment.
genetics_knock down_suppress	36356793	hsa-mir-146a	Epidermodysplasia Verruciformis	Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection. Knockdown of GW182 or Ago2 could weaken the replication ability of exosomal EV71 RNA in recipient cells through decreasing the amount of miR-146a in exosomes, but did not affect the package of viral RNA into exosomes.
exosome	36356793	hsa-mir-146a	Enterovirus Infections	Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection.
circRNA target	36356557	hsa-mir-758	Breast Neoplasms	3p, which might be a novel strategy for breast cancer suppression.
lncRNA target	36356379	hsa-mir-93	Carcinoma, Renal Cell	5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1.
lncRNA target	36356379	hsa-mir-93	Kidney Calculi	5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1.
genetics_overexpression_promote	36356335	hsa-mir-432	Squamous Cell Carcinoma of Head and Neck	5p was inhibited or DNMT3B was overexpressed, the growth and EMT of LSCC cells were stimulated despite ciRS-7 silencing.
other	36355333	hsa-mir-148a	Alzheimer Disease	One of these genes, hsa-miR-148a-3p, might be considered as a new biomarker for Alzheimer's disease diagnosis.
genetics_knock down_promote	36355210	hsa-mir-223	Stomach Neoplasms	3p) in GC cell biology and signaling pathway activation were examined by targeted knockdown (KD) or overexpression (OE) of ECT2 and miR
other	36354672	hsa-mir-130b	Glioblastoma	3p, and -34a-5p not only in the formation of NS, but also in the regulation of malignant growth and invasion of GBM.
genetics_overexpression_promote	36354205	hsa-mir-96	Uterine Cervical Neoplasms	TRIM52-AS1 inhibition or IGF2BP2 overexpression neutralized the inhibition of silencing miR
circulation_biomarker_diagnosis_up	36354186	hsa-mir-3	Spinal Cord Injuries	5p upregulation alleviated the leakage of the blood-spinal cord barrier (BSCB) induced by SCI and improved the neurological functions of SCI rats, as evidenced by the Basso, Beattie, and Bresnahan (BBB) scores and Evans blue staining.
other	36353991	hsa-mir-223	Thyroid Cancer, Papillary	RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA.
other	36353991	hsa-mir-223	Myocardial Infarction	RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA.
transcription factor target	36353937	hsa-mir-550a	Carcinoma, Hepatocellular	In addition, we also found that miR-550a-5p could suppress the growth of HCC in vivo via a xenograft tumor model assay.
circulation_biomarker_prognosis_ns	36353917	hsa-mir-223	Respiratory Distress Syndrome	Thus, circulating MV-miR-223 may be a potential biomarker in prognosticating patient-centered outcomes and predicting mortality in ARDS.
circulation_biomarker_prognosis_up	36353665	hsa-mir-155	Diabetic Foot	CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU.
circulation_biomarker_prognosis_up	36353665	hsa-mir-155	Diabetes Mellitus, Type 2	CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU.
transcription factor target	36353514	hsa-mir-424	Premature Birth	Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR
transcription factor target	36353514	hsa-mir-424	Trophoblast Dysfunction	Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR
transcription factor target	36352829	hsa-mir-543	Parkinson Disease	Our results highlight the idea that dysregulation of miR-543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD.
circRNA target	36352482	hsa-mir-217	Endometrial Neoplasms	hsa_circ_0023404 inhibit miR-217 as sponge which inhibit endometrial cancer cell growth and metastasis.
circulation_biomarker_prognosis_up	36352360	hsa-mir-451	Cholangiocarcinoma	RESULTS: The tissue and serum expression of miR-451 was decreased in cholangiocarcinoma compared with corresponding normal samples.
other	36352275	hsa-mir-423	Glioma	Finally, miR3p's biological functions of in effecting the cell proliferative, migratory, and invasive capabilities of glioma were investigated by performing Cell Counting Kit-8 (CCK-8) and Transwell assays.
lncRNA target	36352177	hsa-let-7a	Glioma	CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis.
lncRNA target	36352177	hsa-mir-29b	Glioma	CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis.
transcription factor target	36352176	hsa-mir-34a	Triple Negative Breast Neoplasms	We found that p53 could inhibit the expression of PD-L1 via miR-34a and that miR-34a could inhibit both cell activity and migration and promoted apoptosis and cytotoxicity in TNBC.
lncRNA target	36352081	hsa-mir-195	Small Cell Lung Carcinoma	5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future.
lncRNA target	36352081	hsa-mir-101	Small Cell Lung Carcinoma	5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future.
other	36351608	hsa-mir-210	Bacterial Infections	At that time, we started research on RNA and bacterial infection and revealed that miR-210, a small RNA in the gastric epithelial cells, is involved in gastric diseases caused by Helicobacter pylori in-fection.
other	36351549	hsa-mir-1	Endothelial Barrier Dysfunction	AGEs induced endothelial cell senescence and endothelial barrier dysfunction by regulating miR3p/MLCK signaling pathway.
other	36351490	hsa-mir-133a	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
other	36351490	hsa-mir-16	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
other	36351490	hsa-mir-133b	Simian Acquired Immunodeficiency Syndrome	Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression.
genetics_GWAS	36350621	hsa-mir-28	Myopia	3p as a novel risk factor for myopia through a genetic association study of the PAX6 gene.
transcription factor target	36350418	hsa-mir-155	ankylosing spondylitis 1	Our primary objective was to explore the role of miR-155 and its targeted factors in AS pathogenesis.
circulation_biomarker_prognosis_ns	36350075	hsa-mir-195	Subarachnoid Hemorrhage	5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients.
circulation_biomarker_prognosis_ns	36350075	hsa-mir-195	Vasospasm, Intracranial	5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients.
other	36349193	hsa-mir-425	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349193	hsa-mir-141	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349193	hsa-mir-7	Squamous Cell Carcinoma of Head and Neck	5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC.
other	36349191	hsa-mir-1321	Glioma	In conclusion, our findings showed that oncogene NQO1 and antioncogene miR-1321 bind to oncogene SERPINA1 to affect proliferation and apoptosis of glioma cells, which can bring new solution of antitumor treatments for glioma in the future.
other	36349063	hsa-mir-146b	Heart Injuries	Receiver operating characteristic curve and correlation analysis showed that cTnI and miR-146b had relatively high predictive values for chronic myocardial injury (area under the curve, 0.83 and 0.71, respectively) and were closely correlated with myocardial damage. These data suggested that CK, cTnI and FABP3 were relatively sensitive to DOX-induced acute myocardial injury, whereas cTnI and miR-146b were relatively sensitive to DOX-induced chronic myocardial injury.
other	36348805	hsa-mir-34a	Fibrosis, Renal	Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study.
other	36348805	hsa-mir-34a	Diabetes Mellitus	Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study.
other	36348568	hsa-mir-21	Carcinoma, Hepatocellular	CONCLUSION: miR-21 has a moderate overall performance in diagnosing HCC and may serve as a potential non-invasive marker for this early-stage disease.
other	36348379	hsa-mir-27b	Carcinoma, Hepatocellular	Mechanistically, circRanGAP1 as an oncogene promotes HCC progression by miR-27b-3p/NRAS/ERK axis, furthermore, affects the infiltration level of tumor-associated macrophages probably by sponging miR-27b-3p. CONCLUSION: These results reveal that circRanGAP1 is a HCC oncogene that function by the miR-27b-3p/NRAS/ERK axis and regulates the infiltration levels of tumor-associated macrophages by sponging miR-27b-3p.
lncRNA target	36348305	hsa-mir-145	Colorectal Neoplasms	5p is a tumor suppressor at early stage of CRC, and an oncogene at advanced stage of CRC.
exosome	36348269	hsa-mir-150	Hyperalgesia	CONCLUSION: BMSC-derived exosomal miR
transcription factor target	36348252	hsa-mir-122	Cholangiocarcinoma	5p was found to act as a post-transcriptional regulator of FUT8 and proved to inhibit FUT8 expression and then suppress the proliferation and migration ability of iCCA cell lines.
circulation_biomarker_diagnosis_up	36348199	hsa-mir-559	psoriasis 1	Furthermore, serum miRNA-559 and MTDH displayed comparable diagnostic accuracy in discriminating psoriatic patients from controls.
genetics_overexpression_promote	36348139	hsa-mir-29c	Squamous Cell Carcinoma of Head and Neck	Additionally, overexpressed C1QTNF6 facilitated these biological functions of HNSCC cells while upregulating miR-29c-3p reversed such effect.
other	36348020	hsa-mir-196b	Colorectal Neoplasms	METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b.
lncRNA target	36347825	hsa-mir-138	Laryngeal Neoplasms	5p inhibitor.
lncRNA target	36347300	hsa-mir-26b	Brain Injuries	CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis.
lncRNA target	36347300	hsa-mir-26b	Subarachnoid Hemorrhage	CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis.
other	36346713	hsa-mir-498	Esophageal Neoplasms	Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression
lncRNA target	36346578	hsa-mir-1224	Diabetic Retinopathy	All in all, SPAG5-AS1 attenuates diabetic retinal vascular dysfunction through miR5p/IRS-1 axis, providing a potential therapeutic strategy for DR.
transcription factor target	36345369	hsa-mir-34a	Diabetic Nephropathies	In conclusion, the above data suggested that AIF-1 regulated the levels of inflammation, oxidative stress, and autophagy in HRGECs via miR-34a/ATG4B pathway to contribute to the pathogenesis of diabetic kidney disease.
transcription factor target	36344974	hsa-mir-1199	Prostatic Hyperplasia	5p inhibitor increased SRD5A2 expression in BPH-1 cells.
lncRNA target	36344947	hsa-mir-21	Uterine Cervical Neoplasms	CONCLUSIONS: MEG3 performing as ceRNA promotes cisplatin sensitivity in CC cells through the miR-21/PTEN axis.
circulation_biomarker_diagnosis_up	36344812	hsa-mir-27	Scleroderma, Systemic	MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease.
circulation_biomarker_diagnosis_up	36344812	hsa-mir-27a	Scleroderma, Systemic	MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease.
genetics_overexpression_promote	36343886	hsa-mir-421	Carcinoma, Renal Cell	Overexpression of miR-421 has reversed the anti-tumor function of circSCNN1A in RCC cells.
other	36343560	hsa-mir-148a	Drug Hypersensitivity	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Neurotic Disorders	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Fatigue	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Mood Disorders	RESULTS: A significantly negative correlation was observed between relative miR-148a expression in breast milk and the total mood disturbance T-score.
other	36343560	hsa-mir-148a	Substance Withdrawal Syndrome	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
other	36343560	hsa-mir-148a	Pituitary Diseases	Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk.
circulation_biomarker_diagnosis_ns	36343541	hsa-mir-513a	Pancreatic Carcinoma	Plasmids altering LINC01234, miR-513a-3p and H6PD expression were transfected into pancreatic cancer cells to assess the change in biological behaviors of pancreatic cancer cells.
lncRNA target	36343490	hsa-mir-10b	Inflammatory Bowel Diseases	Thus, miR-10b may be expected to be a new target for the treatment of IBD.
lncRNA target	36342850	hsa-mir-21	Triple Negative Breast Neoplasms	This compound was incorporated into the design of a next-generation RiboTAC that targeted the microRNA-21 (miR-21) precursor and alleviated a miRassociated cellular phenotype in triple-negative breast cancer cells.
other	36341564	hsa-mir-125b	Urinary Bladder Neoplasms	Furthermore, the modulation of miR-34a and miR-125b gene expression in association with increased MAGE-A6 and MAGE-A11 genes could open a new horizon in the improvement of bladder cancer.
transcription factor target	36341347	hsa-mir-93	Polycystic Ovary Syndrome	5p as a new molecular target for improving the function of GCs in PCOS patients.
lncRNA target	36341225	hsa-mir-17	Metabolic Diseases	TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR
lncRNA target	36341225	hsa-mir-17	Diabetes, Gestational	TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR
genetics_knock down_suppress	36340580	hsa-mir-640	Osteosarcoma	MCAM knockdown repressed OS cell growth and migration, while additional miR-640 depletion partially abolished the anticancer effects of MCAM knockdown in OS cells.
other	36340453	hsa-mir-135b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-98	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-191	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-146b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-150	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-29a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-134	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-148a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-23b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-34c	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-181d	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-133b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-155	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-17	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7d	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-29b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-125b	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-let-7f	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-16	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-92a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-15a	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-372	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-142	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-143	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-138	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
other	36340453	hsa-mir-181c	Breast Neoplasms	Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7).
lncRNA target	36339585	hsa-mir-326	Osteoarthritis	Correspondingly, intracellular transfer of circPARD3B through OE-circPARD3B-SMSCs-sEV could postpone disease progression through a functional module regulated angiogenesis of circPARD3B-miRSIRT1, providing a novel therapeutic strategy for OA.
other	36338963	hsa-mir-141	Hemangioma, Infantile	5p) were significantly differentially expressed between IH and normal control (p < 0.05).
other	36338962	hsa-mir-147a	Ovarian Neoplasms	As a result, six genes (CDT1, CNIH4, CRLS1, LIMCH1, POC1A, and SNX13), and two miRNAs (mir-147a, and mir-103a-3p) were suggested as novel candidate prognostic biomarkers for ovarian cancer.
genetics_overexpression_suppress	36338839	hsa-mir-164	Dehydration	The heterologous accumulation of miR164g in Arabidopsis thaliana results in enhanced sensitivity to drought stress, while overexpression of MsNAC022 in Arabidopsis and the cultivated apple line 'GL-3' (Malus domestica Borkh.) lead to enhanced tolerance to drought stress by raising the ROS scavenging enzymes activity and related genes expression levels, particularly PEROXIDASE (MsPOD).
circulation_biomarker_diagnosis_up	36338741	hsa-mir-1228	Breast Neoplasms	Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes.
circulation_biomarker_diagnosis_up	36338741	hsa-mir-191	Breast Neoplasms	Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes.
other	36338672	hsa-mir-519b	Endometriosis	The present study aimed to investigate whether LncRNA HOTAIR regulates cell invasion and migration in endometriosis by regulating the miR-519b-3p/PRRG4 pathway.
lncRNA target	36338027	hsa-mir-29a	Laryngeal Neoplasms	In conclusion, hBMSC-derived Exo with upregulated miR-29a-3p inhibited laryngocarcinoma progression via regulating PTEN, providing a potential diagnostic and therapeutic target in this disease.
target gene	36337243	hsa-mir-195	Uterine Cervical Neoplasms	Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis.
other	36337027	hsa-mir-320c	Lung Neoplasms	Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.
other	36337027	hsa-mir-320d	Lung Neoplasms	Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC.
other	36336926	hsa-mir-30	Atherosclerosis	CONCLUSION: These results suggested that circIRAK1 upregulated TRIM14 by interacting with miR5p, consequently contributing to ox-LDL-induced endothelial cell injury in AS.
exosome	36336217	hsa-mir-625	Colorectal Neoplasms	The current results indicated that CAFs-Exo was directly internalized by CRC cells, and exosomal miR
other	36336032	hsa-mir-101a	Reperfusion Injury	CONCLUSION: Altogether, RGD1564534 elevates the expression of Dusp1 by competitively binding to miR-101a-3p, which facilitates mitochondrial autophagy-mediated inactivation of NLRP3 inflammasome and thus retards cerebral I/R injury.
genetics_overexpression_promote	36336031	hsa-mir-140	Subarachnoid Hemorrhage	SAH rats were treated with the EVs sourced from microglia overexpressing miR
lncRNA target	36335997	hsa-mir-144	Schizophrenia	3p/ZBTB20/ERK/CREB1 signalling might be associated with schizophrenia-like abnormalities, suggesting potential therapeutic targets for future schizophrenia treatment.
genetics_knock down_suppress	36335987	hsa-mir-506	Ovarian Neoplasms	CONCLUSION: XIST knockdown inhibited autophagy and carboplatin resistance of OC through FOXP1/protein kinase B (AKT)/mammalian target of rapamycin pathway by targeting miR
transcription factor target	36335879	hsa-mir-614	Breast Neoplasms	5p suppressed the expression of TXNRD1 by directly binding to the 3'-untranslated region (UTR), and TXNRD1 inhibition significantly repressed the proliferation and metastasis capacity of BC cells upon Cd exposure.
lncRNA target	36335706	hsa-mir-21	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-150	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-375	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-103a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-155	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-140	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-20a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-130a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-125a	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
lncRNA target	36335706	hsa-mir-101	salivary gland adenoid cystic carcinoma	3p inhibit the salivary adenoid cystic carcinoma progression.
other	36335210	hsa-mir-23b	Endometrial Neoplasms	Decreased miR-23b expression was associated with worse survival of EC patients.
other	36335210	hsa-mir-199a	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-221	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-146	Endometrial Neoplasms	Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2.
other	36335210	hsa-mir-34a	Endometrial Neoplasms	Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2.
other	36335210	hsa-mir-125b	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36335210	hsa-mir-451a	Endometrial Neoplasms	We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE.
other	36334906	hsa-mir-1	Wounds and Injuries	Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality.
other	36334906	hsa-mir-132	Wounds and Injuries	Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality.
other	36334875	hsa-let-7f-1	Intervertebral Disc Degeneration	3p/Bmal1/autophagy axis provides a potential therapeutic strategy for the clinical treatment of IDD.
circRNA target	36334805	hsa-mir-888	Triple Negative Breast Neoplasms	Furthermore, we found that inhibiting circRAD54L2 expression markedly reduced the invasion, metastasis, and proliferation of breast cancer cells via sponging of the miR-888 family, which downregulated the expression of pyruvate dehydrogenase kinase 1 (PDK1). CONCLUSION: Our results showed that circRAD54L2 could regulate PDK1 expression by sponging the miR-888 family competing for the ceRNA mechanism, indicating that circRAD54L2 may act as an essential upstream regulator and providing further mechanistic evidence to support the notion that circRAD54L2/miR-888s/PDK1 is a promising therapeutic target in the treatment of breast cancer.
genetics_knock down_promote	36334791	hsa-mir-19a	Neuralgia	To investigate into the role of miR-19a-3p and KLF7 in NP of rats, the knockdown of miR-19a-3p alone or along with KLF7 downregulation in rats were achieved through lentivirus injection.
other	36334781	hsa-mir-9	Stress Disorders, Post-Traumatic	Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group.
other	36334781	hsa-mir-34c	Stress Disorders, Post-Traumatic	Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group.
other	36334504	hsa-mir-106b	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-122	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-200c	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-423	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-1291	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
other	36334504	hsa-mir-4433b	Polycythemia, High Altitude	5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated.
lncRNA target	36334219	hsa-mir-449a	Cardiomyopathies	Collectively, our study established CFAR as a new profibrotic factor acting through a novel miR-449a-5p/LOXL3/mTOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases.
circulation_biomarker_diagnosis_ns	36333771	hsa-mir-155	Acute Lung Injury	5p in the plasma.
circulation_biomarker_diagnosis_ns	36333771	hsa-mir-155	Pancreatitis	5p in the plasma.
other	36333728	hsa-mir-17	Diabetic Foot	3p had a negative regulatory effect on Flk-1.
transcription factor target	36333342	hsa-mir-584	Atherosclerosis	These results suggest that OASL1/OASL regulates endothelial biology by protecting NOS3 mRNA and targeting miR-584 represents a rational therapeutic strategy for eNOS maintenance in vascular disease.
genetics_GWAS	36333293	hsa-mir-9	Squamous Cell Carcinoma of Head and Neck	These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA
genetics_GWAS	36333293	hsa-mir-9	Endometrial Neoplasms	These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA
genetics_overexpression_promote	36332797	hsa-mir-15a	Colorectal Neoplasms	Accordingly, overexpression of SIRT4 suppresses the miR-15a-5p-mediated enhancement in the proliferation, migration, and invasion of CRC cells, while the opposite phenotypes were observed after inhibition of SIRT4.
circulation_biomarker_diagnosis_up	36332335	hsa-mir-21	Colorectal Neoplasms	Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma.
circulation_biomarker_diagnosis_up	36332335	hsa-mir-221	Colorectal Neoplasms	Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma.
target gene	36331809	hsa-mir-18a	Urinary Bladder Neoplasms	LncRNA GAS5 regulates the Wnt/beta-catenin pathway through the miR-18a-5p/AXIN2/GSK3β axis to inhibit the proliferation and migration of bladder cancer cells.
genetics_knock down_promote	36331285	hsa-mir-152	Cholangiocarcinoma	PDK1 overexpression reversed the inhibition effect of miR
circRNA target	36330643	hsa-mir-424	Osteoarthritis	CONCLUSION: Hsa_circ_0004662 facilitates OA progression via the miR5p/VEGFA axis.
circulation_biomarker_prognosis_ns	36330573	hsa-mir-211	Vascular Calcification	The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR
circulation_biomarker_prognosis_ns	36330573	hsa-mir-211	Kidney Failure, Chronic	The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR
lncRNA target	36330459	hsa-mir-26a	Ischemic Stroke	CONCLUSIONS: TUG1/miR-26a, which may act as a regulatory axis in angiogenesis following ischemic stroke, can be considered a potential target for cerebral infarction therapy.
circulation_biomarker_diagnosis_up	36330052	hsa-mir-99a	Squamous Cell Carcinoma of Head and Neck	Furthermore, plasma EVs miR-99a-5p also distinguished early HNSCC with AUC of 0.7394 (95% CI: 0.6284-0.8504; p = 0.0002), with 79.07% sensitivity and 61.54% specificity, respectively.
circulation_biomarker_prognosis_up	36330017	hsa-mir-126	Infarct-Related Artery Total Occlusion	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-21	Infarct-Related Artery Total Occlusion	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-21	Myocardial Infarction, Acute	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
circulation_biomarker_prognosis_up	36330017	hsa-mir-126	Myocardial Infarction, Acute	5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR).
lncRNA target	36329790	hsa-mir-153	Prostatic Neoplasms	CONCLUSION: MiR-153 is up-regulated in PC tissues and may play an important role in aggressive PC by targeting potential target genes.
other	36329788	hsa-mir-129	Melanoma	lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma.
genetics_knock down_promote	36329586	hsa-mir-4324	Breast Neoplasms	CONCLUSIONS: High expression of Talin2 is associated with lymph node metastasis and HER-2 overexpression in breast cancer patients.Down-regulation of miR-4324 inhibits the proliferation, invasion and migration and induces apoptosis of breast cancer cells, and the inhibitory effect of miR-4324 knockdown on breast cancer cell migration is mediated probably by targeted inhibition of Talin2 expression.
transcription factor target	36329581	hsa-mir-16	Carcinoma, Non-Small-Cell Lung	5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells.
transcription factor target	36329581	hsa-mir-16	Breast Neoplasms	5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells.
genetics_knock down_promote	36329557	hsa-mir-637	Esophageal Squamous Cell Carcinoma	Loss of miR-637 promotes cancer cell stemness via WASH/IL-8 pathway and serves as a novel prognostic marker in esophageal squamous cell carcinoma.
other	36329419	hsa-mir-155	Multiple Sclerosis	CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required.
other	36329419	hsa-mir-145	Multiple Sclerosis	CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required.
other	36328940	hsa-mir-141	Anorectal Malformations	miR3p was downregulated in the ARM group, whereas Ubtd2 increased and colocalized with TUNEL-positive cells.
transcription factor target	36328305	hsa-mir-222	Spinal Cord Injuries	3p could alleviate the mitochondrial pathway-mediated apoptosis and motor dysfunction in rats after SCI by targeting Bbc3 and Bim.
lncRNA target	36328133	hsa-mir-374b	Neovascularization, Pathologic	Moreover, treatment of appropriate animal models either with a miR-374b-5p mimicry or with inhibitors of either stat3 acetylation, DNMT1, or EZH2, leads to marked inhibition of MCPpromoted neovascularization and tumor growth.
circulation_biomarker_diagnosis_ns	36328028	hsa-mir-1	Sarcopenia	CONCLUSIONS: These results suggest that circulating miR
circulation_biomarker_diagnosis_ns	36328028	hsa-mir-1	Heart Failure, Chronic	CONCLUSIONS: These results suggest that circulating miR
exosome	36327876	hsa-mir-29b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Extracellular vesicles derived from human bone marrow stem cells inhibit acute lymphoblastic leukemia cell growth by inhibiting MAPK pathway via the miR-29b-3p/GDF15 axis.
lncRNA target	36327779	hsa-mir-429	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-944	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-326	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-133b	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
lncRNA target	36327779	hsa-mir-451a	Carcinoma, Non-Small-Cell Lung	Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms.
genetics_knock down_suppress	36327671	hsa-mir-145	Ovarian Neoplasms	5p reversed the effects of circ_0015756 knockdown on OC cells.
circulation_biomarker_diagnosis_ns	36327567	hsa-mir-106a	hereditary diffuse gastric cancer	The Cas13a-bHCR based SERS assay of gastric cancer-related miRNA-106a (miR-106a) can be achieved within 60 min and output significantly enhanced SERS signal due to the multiple signal amplification, which possesses a good linear calibration curve from 10 aM to 1 nM with the limit of detection (LOD) low to 8.55 aM for detecting gastric cancer-related miR-106a in human serum.
transcription factor target	36327448	hsa-mir-21	Breast Neoplasms	To overcome these limitations, synergistic combinatorial anti-tumor effect of Granzyme B (GrB) and miR-21 inhibitor (miR-21i) for breast cancer therapy through a new co-delivery system was investigated in present study. In conclusion, the nanocapsules for simultaneously delivery of GrB and miR-21i produce a synergistic effect in human breast cancer therapy.
other	36327243	hsa-mir-199a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
other	36327243	hsa-mir-26a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
other	36327243	hsa-mir-130a	Preterm Premature Rupture of the Membranes	Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05).
circulation_biomarker_diagnosis_ns	36327023	hsa-mir-367	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation.
circulation_biomarker_diagnosis_ns	36327023	hsa-mir-22	Precursor Cell Lymphoblastic Leukemia-Lymphoma	MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation.
genetics_knock down_promote	36326978	hsa-mir-622	Glioma	miR-622 knockdown reversed the effect of Propofol on glioma progression.
target gene	36326553	hsa-mir-29a	Pneumonia	LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide.
target gene	36326553	hsa-mir-29a	Pulmonary Fibrosis	LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide.
transcription factor target	36326533	hsa-mir-133a	Hypercholesterolemia	In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats.
other	36326316	hsa-mir-590	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-15a	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-449a	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-381	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
other	36326316	hsa-mir-454	Tuberculosis	5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients.
lncRNA target	36326314	hsa-mir-8084	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-128	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-8084	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-494	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-494	Prostatic Hyperplasia	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326314	hsa-mir-128	Prostatic Neoplasms	DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer.
lncRNA target	36326096	hsa-mir-873	Esophageal Squamous Cell Carcinoma	In conclusion, UCA1 can protect Human Umbilical Vein Endothelial Cells from ox-LDL-induced injury via the miR5p/MAPK8 axis.
exosome	36325775	hsa-mir-204	Myocardial Reperfusion Injury	Results hUC-MSCs had adipogenic and osteogenic differentiation capabilities,and the exosomes were successfully identified.Compared with the negative control group,the miR-204 mimic group showed up-regulated expression of miR-204 in hUC-MSCs and their exosomes(P<0.001,P<0.001).Compared with the sham operation group,the modeling of I/R increased the left ventricular end-diastolic diameter(LVEDD)(P<0.001),left ventricular end-systolic diameter(LVESD)(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P<0.001),and CD11c(P<0.001).Meanwhile,it lowered the left ventricular ejection fraction(LVEF)(P<0.001),left ventricular fractional shortening(LVFS)(P<0.001),Arg-1(P<0.001),IL-10(P<0 CD206(P<0.001).Compared with those in the I/R group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P=0.010),and CD11c(P<0.001) reduced,while LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.028),and CD206(P=0.022) increased in the hUC-MSC exosomes group.Compared with those in the negative control group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P=0.001),and the levels of IL-1beta(P=0.048),TNF-alpha(P<0.001),and CD11c(P=0.007) reduced,while the LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.001),and CD206(P=0.001) increased in the miR-204 mimic group.
other	36325355	hsa-mir-181c	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-125b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-15b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
other	36325355	hsa-mir-193b	Leukemia, Lymphocytic, Chronic, B-Cell	We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low).
transcription factor target	36324898	hsa-mir-532	Colorectal Neoplasms	3p/si-KRAS might provide a promising potential strategy for inhibiting the malignant phenotypes of CRC cells.
transcription factor target	36324569	hsa-mir-140	Colorectal Neoplasms	Our results, both in vitro and in vivo, suggest that miR-140 may act as a tumor suppressor and plays an important role in DSB DNA repair and, consequently, CRC therapy response.
other	36324503	hsa-mir-23a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-29c	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-29b	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-200a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-145	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-22	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-20a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-34a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
other	36324503	hsa-mir-27a	Multiple Sclerosis	3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found.
transcription factor target	36324256	hsa-mir-101	Pre-Eclampsia	3p in placenta contributes to the development of PE by suppressing WDR5-mediated proliferation and invasion of trophoblast.
lncRNA target	36322830	hsa-mir-372	hereditary diffuse gastric cancer	Mining of this dataset across the human transcriptome defined a drug-like fragment that potently and specifically targeted the microRNA-372 hairpin precursor, inhibiting its processing into the mature, functional microRNA and alleviating invasive and proliferative oncogenic phenotypes in gastric cancer cells.
other	36322827	hsa-mir-148a	Leukemia, Myeloid	miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.
other	36322719	hsa-mir-29a	Neovascularization, Pathologic	Our data suggest that miR-29a may be a promising clinical candidate for the treatment of neovascular diseases.
other	36322706	hsa-mir-125a	Brain Ischemia	RESULTS: CircSTK39 and ERCC6 expression were significantly downregulated, but miR-125a-5p expression was upregulated in the lens tissues of ARC patients and H(2)O(2)-treated SRA01/04 cells.
genetics_knock down_promote	36322370	hsa-mir-340	Spinal Cord Injuries	Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis.
genetics_knock down_promote	36322370	hsa-mir-340	Subarachnoid Hemorrhage	Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis.
circulation_biomarker_diagnosis_down	36322282	hsa-mir-29a	Graves Disease	Collectively, our results demonstrate that miR-29a-3p emerges as a post-transcriptional brake to limit circulating Tfh memory cell response in GD patients and may be involved in the pathogenesis of GD.
other	36321868	hsa-mir-495	Squamous Cell Carcinoma of Head and Neck	Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC.
other	36321868	hsa-mir-495	Periodontitis	Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC.
other	36321836	hsa-mir-155	Esophageal Squamous Cell Carcinoma	MIR155HG encodes a precursor RNA of microRNA-155 (miRNA-155).
transcription factor target	36321792	hsa-mir-221	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Moreover, changes were observed in the expression of CDKN1B, a known target of miR
transcription factor target	36321792	hsa-mir-222	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Moreover, changes were observed in the expression of CDKN1B, a known target of miR
lncRNA target	36321407	hsa-mir-181c	Colorectal Neoplasms	To be concluded, SPR inactivates PI3K/AKT signaling pathway to suppress CRC cell proliferation, invasion, and migration via miR-181c/d-5p/RBM47.
exosome	36321189	hsa-mir-106	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-501	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-20a	Prostatitis, Chronic	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-20a	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-106	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
exosome	36321189	hsa-mir-501	Chronic   Pelvic Pain Syndrome	In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis.
genetics_GWAS	36320325	hsa-mir-145	Urinary Bladder Neoplasms	MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa.
genetics_GWAS	36320325	hsa-mir-143	Urinary Bladder Neoplasms	MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa.
lncRNA target	36320323	hsa-mir-196a	Huntington Disease	Taken together, miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in HD, supporting the neuroprotective functions of miR-196a through neuronal cytoskeleton in HD.
exosome	36319884	hsa-mir-222	AIDS-Related Complex	Exosomal miR
other	36319782	hsa-mir-10	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
other	36319782	hsa-mir-21	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
other	36319782	hsa-mir-124	Multiple Sclerosis	CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development.
exosome	36319622	hsa-mir-181d	Carcinoma, Renal Cell	Further investigation revealed that CAFs could enhance cancer stemness through delivering exosomes to RCC cells, and miR-181d-5p was identified as the critical exosomal miRNA in CAF-secreted exosomes by small RNA sequencing and subsequent screening assays. Mechanistically, exosomal miR-181d-5p transferred from CAFs to RCC cells directly suppressed the expression of ring finger protein 43 (RNF43) and activated Wnt/beta-catenin signaling pathway, thus promoted cancer stemness and tumor progression.
other	36319098	hsa-mir-196b	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-874	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-296	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-503	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-150	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-100	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-940	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-543	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-628	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
other	36319098	hsa-mir-299	Essential Hypertension	3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group.
lncRNA target	36319097	hsa-mir-155	Pulmonary Disease, Chronic Obstructive	These results suggest that miR-155 activates the PTEN/PI3K/Akt signaling pathway by targeting PIK3R1 to promote the occurrence and development of COPD, which provides new evidence for the use of miR-155 in the treatment of COPD.
other	36319063	hsa-mir-125b	Colonic Neoplasms	Furthermore, in human colon adenocarcinoma patients, we verified that miR-125b-5p expression was downregulated, and low levels of miR-125b-5p were associated with poor prognosis.
other	36318963	hsa-mir-29a	Alzheimer Disease	In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD.
other	36318963	hsa-mir-29	Alzheimer Disease	In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD.
other	36317581	hsa-mir-1	Squamous Cell Carcinoma of Head and Neck	This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects.
other	36317581	hsa-mir-21	Squamous Cell Carcinoma of Head and Neck	This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects.
genetics_knock down_promote	36317454	hsa-mir-138	Colorectal Neoplasms	5p was downregulated in CRC and its knockdown accelerated CRC progression.
target gene	36317339	hsa-mir-181a	Stomach Neoplasms	TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop.
genetics_GWAS	36317205	hsa-mir-146	Primary Ovarian Insufficiency	RESULTS: Compared with control group, the expression level of miRNA-146 in POI group was significantly lower, the expression level of OX-LDL and ROS were significantly higher, and the ovarian volume and peak systolic blood flow velocity of ovarian artery were significantly decreased in POI group.
other	36316703	hsa-mir-29b	Colorectal Neoplasms	Functional assays revealed that LIFR-AS1 could competitively bind to hsa-miR-29b-3p, and repressed colon cancer cell proliferation, colony formation and invasion.
circRNA target	36316592	hsa-mir-185	Diabetic Nephropathies	Circ_0008529 might be a potential target for DN, which regulated DN progression via miR5p/SMAD2 pathway.
lncRNA target	36316351	hsa-mir-34c	Stomach Neoplasms	Accordingly, our results support that E2F1 is an engaging target of drug development in tumor growth and aggressive proliferation of GC, and favorable results can be achieved through tumor suppressor lncRNA GAS5/miR-34c axis in GC.
other	36316110	hsa-mir-23b	Stomach Neoplasms	Moreover, low miR-23b expression predicted longer 10-year survival (P=0.0066) in patients with GC. MiR-23b-5p expression status could serve as a prognostic marker for survival in patients with GC.
circRNA target	36315981	hsa-mir-587	Uterine Cervical Neoplasms	CONCLUSION: Circ_0031027 inhibited the enlargement of CC by miR-587/SOCS5.
lncRNA target	36315357	hsa-mir-29b	Cardiomyopathies	Overall, our findings imply that induction of miR-29b-3p, which negatively regulates GSK-3beta and BMF expression, attenuates CME-induced myocardial injury, suggesting a novel potential therapeutic target for cardioprotective after CME.
circRNA target	36315192	hsa-mir-190a	Reperfusion Injury, Renal Ischemia	Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway. Taken together, our data showed that circRNA_45478/miR-190a-5p/PHLPP1 axis mediated the progression of ischemic AKI.
genetics_overexpression_promote	36314369	hsa-mir-92a	Uterine Cervical Neoplasms	Functional rescue assays revealed that miR-92a-3p overexpression or BTG2 downregulation reversed the inhibitory role of CARMN overexpression in CC cell growth.
circRNA target	36314002	hsa-mir-370	FG syndrome	CONCLUSION: The hsa-circ-0005238 modulates FGR pathogenesis by inhibiting trophoblast cell invasion and migration through sponging hsa-miR3p.
lncRNA target	36313765	hsa-mir-34a	Uterine Cervical Neoplasms	A pair of ceRNAs (CA9/ULBP2) could be involved in the carcinogenesis and development of cervical cancer, and the potential target might be hsa-miR-34a. Further research found that the ceRNA pairs of ULBP2/CA9 could regulate cervical cancer through hsa-miR-34a.
circRNA target	36313671	hsa-mir-361	Colonic Neoplasms	CircHADHA increased the expression of ATG13 via miR-361 in both colon epithelial and cancer cells. CircHADHA promoted autophagy by regulating ATG13 via miR-361 in both colon epithelial and cancer cells.
genetics_knock down_suppress	36313631	hsa-let-7g	Gallbladder Neoplasms	The loss of let-7g-5p enhanced the expression of IGF2BP3 and improved GBC progression.
target gene	36313626	hsa-mir-1	Breast Neoplasms	The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31.
other	36313468	hsa-mir-103a	Colorectal Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-193b	Colorectal Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-103a	Colonic Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
other	36313468	hsa-mir-193b	Colonic Neoplasms	In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer.
circulation_biomarker_diagnosis_up	36313425	hsa-mir-486	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-let-7e	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-223	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-152	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-199a	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
circulation_biomarker_diagnosis_up	36313425	hsa-mir-148a	Aortic Valve Insufficiency	The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR
other	36313069	hsa-mir-642a	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36313069	hsa-mir-652	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36313069	hsa-mir-630	Obesity	In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p.
other	36312756	hsa-mir-129-2	Breast Neoplasms	Furthermore, the expression of miR2-3p in breast cancer patients was about twice that in healthy people.
lncRNA target	36312597	hsa-mir-22a	Hypertension, Pulmonary	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-22a	Hypertension, Portal	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-34a	Hypertension, Portal	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
lncRNA target	36312597	hsa-mir-34a	Hypertension, Pulmonary	"In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc."
other	36312586	hsa-mir-92b	Breast Neoplasms	Moreover, we identified the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer. We discovered the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer, which has not yet been investigated previously.
other	36312469	hsa-mir-139	Carcinoma, Hepatocellular	The SNHG3/THUMP3-AS1-miR5p-SMARCA4 ceRNA network was established and could be assumed to serve as a stimulatory mechanism in HCC.
genetics_knock down_promote	36311891	hsa-mir-7	Carcinoma, Non-Small-Cell Lung	5p knockdown exerted the opposite effects.
exosome	36311808	hsa-mir-466	Heat Stroke	CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke.
exosome	36311808	hsa-mir-466	Brain Injuries	CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke.
other	36311688	hsa-mir-20b	Prostatic Neoplasms	miR-20b-5p is a novel biomarker for detecting prostate cancer.
lncRNA target	36311369	hsa-mir-21	Carcinoma, Renal Cell	Eventually, two novel lncRNAs, AL162377.1 and AF111167.2, targeting the miR
other	36311195	hsa-mir-574	Esophageal Squamous Cell Carcinoma	MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
other	36311189	hsa-mir-146a	Drug Hypersensitivity	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-106a	Drug Hypersensitivity	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-106a	Inflammation	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311189	hsa-mir-146a	Inflammation	Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
other	36311149	hsa-mir-10a	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10a	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135b	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10b	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Asthenozoospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-10a	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Infertility	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
other	36311149	hsa-mir-135a	Oligospermia	In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS.
target gene	36311048	hsa-mir-210	Inflammatory Osteolysis	Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat in fl ammatory or infective osteolysis and identifies a novel role of miR3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression.
other	36310619	hsa-mir-342	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
other	36310619	hsa-mir-142	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
other	36310619	hsa-mir-199a	Ulcerative   Colitis	3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC.
circulation_biomarker_diagnosis_down	36310502	hsa-mir-196a	Squamous Cell Carcinoma of Head and Neck	Additionally, in both DDP-resistant and -sensitive lines, GAS5 showed a cytoplasmic distribution and downregulated miR-196a in OSCC tissues.
other	36310379	hsa-mir-222	Diabetes Mellitus	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes.
other	36310379	hsa-mir-222	Insulin Resistance	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes.
other	36310379	hsa-mir-222	Metabolic Diseases	Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. Altogether, miR-222 exerts a direct effect in metabolic pathways of 3T3-L1 adipocytes that are relevant to adipocyte function, limiting adipogenesis and insulin signaling pathways, offering a mechanistic explanation for its reported association with metabolic diseases.
genetics_overexpression_promote	36309967	hsa-mir-548k	Breast Neoplasms	In this study, the significant overexpression of miR-548k in breast cancer tissues compared to adjacent normal tissues was confirmed.
other	36309937	hsa-mir-29c	Neurodegenerative Diseases	Recent reports have suggested that abnormal miR-29c expression in hippocampus have been implicated in the pathophysiology of some neurodegenerative and neuropsychiatric diseases.
other	36309937	hsa-mir-29c	Brain Diseases	Therefore, miR-29c might be a potential therapeutic agent for TNF-alpha accumulation and toxicity-related brain diseases.
exosome	36309693	hsa-mir-655	Osteosarcoma	LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal.
genetics_knock down_promote	36309620	hsa-mir-378a	Carcinoma, Renal Cell	The results of loss-of-function experiments showed that inhibition of TOB2 reversed the inhibitory roles of miR-378a-3p inhibitor on RCC progression.
transcription factor target	36309619	hsa-mir-27a	Lung Neoplasms	METHODS: We detect the expression of miR-27a after exposure to hypoxia conditions in lung cancer cells via qPCR.
target gene	36309571	hsa-mir-29a	Rhabdomyosarcoma	A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a.
circulation_biomarker_diagnosis_up	36308704	hsa-mir-182	Parkinson Disease	5p delivered by plasma exosomes promotes sevoflurane-induced neuroinflammation and cognitive dysfunction in aged POCD rats by targeting BDNF and activating the NF-kappaB pathway.
transcription factor target	36308623	hsa-mir-106b	Intervertebral Disc Degeneration	Our findings demonstrate that targeting miR-106b-5p in intervertebral disc has therapeutic effects on IDD.
other	36308360	hsa-mir-182	Breast Neoplasms	COCLUSION: Down regulation of FOXO3 and up regulation of miR-182 expression was associated with advanced breast cancer.
circulation_biomarker_diagnosis_ns	36307990	hsa-mir-542	Lupus Erythematosus, Systemic	5p expression positively correlated with the levels of polyamine synthetases in peripheral blood mononuclear cells of patients with SLE as well as disease severity.
virus_miRNA	36307872	ebv-mir-BART18	Colorectal Neoplasms	BART18-3p Promotes Colorectal Cancer Progression by Targeting De Novo Lipogenesis
circulation_biomarker_diagnosis_up	36307470	hsa-mir-543	Osteoarthritis	Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA.
circulation_biomarker_diagnosis_up	36307470	hsa-mir-542	Osteoarthritis	Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA.
other	36307001	hsa-mir-195	Carcinoma, Hepatocellular	Several studies found that miR-195 plays an unavoidable role in the regulation of cell proliferation, cycle and apoptosis in hepatocellular carcinoma (HCC).
circulation_biomarker_diagnosis_ns	36306116	hsa-mir-124	Parkinson Disease	MATERIAL AND METHODS: The circHIPK3 and microRNA-124 (miR-124) expression in human serum and cerebral fluid was detected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 92 PD patients and 95 controls.
genetics_knock down_suppress	36306049	hsa-mir-205	Norrie disease	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
genetics_knock down_suppress	36306049	hsa-mir-205	Fibrosis	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
genetics_knock down_suppress	36306049	hsa-mir-205	Inflammation	CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development.
other	36306007	hsa-mir-27b	Thyroid Neoplasms	LINC01089 blocks malignant progression of thyroid cancer by binding miR-27b-3p to enhance the FBLN5 protein level.
genetics_knock down_suppress	36305971	hsa-mir-135b	Protein-Losing Enteropathies	Knockdown of BMPER or overexpression of miR-135b inhibited the osteogenic differentiation of CTS-induced ossification in PLL cells.
genetics_overexpression_suppress	36305754	hsa-mir-133a-2	Uterine Cervical Neoplasms	The overexpression of hsa-mir-133a-2 significantly inhibits the proliferation and invasion of cervical cancer cells.
genetics_GWAS	36305672	hsa-mir-196a-2	Carcinoma, Non-Small-Cell Lung	This nanodevice can detect miR-196a2T with an ultralow detection limit of 2.46 aM; distinguish rare miR-196a2 SNP with a selectivity factor of 0.001%; and even profile miR-196a2T in human tissues for nonsmall cell lung cancer (NSCLC) diagnosis, risk assessment, and cancer type prediction.
transcription factor target	36305548	hsa-mir-140	Breast Neoplasms	3p regulates the expression of USP36, which mediates ubiquitination and regulates the expression of PKM2, and regulates the malignant biological behavior of breast cancer through the energy metabolism process.
other	36305435	hsa-mir-206	Rhinitis, Allergic, Seasonal	miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR.
other	36305435	hsa-mir-126	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-206	Asthma	miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR.
other	36305435	hsa-mir-125b	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-125b	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-126	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-133b	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-181a	Asthma	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-133b	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
other	36305435	hsa-mir-181a	Rhinitis, Allergic, Seasonal	The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction.
genetics_knock down_suppress	36305147	hsa-mir-424	Breast Neoplasms	5p; LINC00473 knockdown impeded the growth, migration, invasion, and epithelial-mesenchymal transition of BC cells, while these effects were abolished by miR
other	36305048	hsa-mir-873	Stomach Neoplasms	CONCLUSION: Our research showed that hsa_circ_0005529 promoted tumorigenic behavior in gastric cancer cells by adsorbing miR5p to modulate ZEB1 levels.
lncRNA target	36304947	hsa-mir-27a	Tuberculosis	RESULTS: Differential miRNA expression profiles were obtained, and miR-27a-3p and miR-30b-5p were highly expressed in patients with TB. CONCLUSION: Our study not only identified differentially expressed miRNAs between the TB and control groups but also revealed that miR-27a-3p and miR-30b-5p regulate proinflammatory cytokine secretion and macrophage differentiation through VDR in macrophages.
lncRNA target	36304901	hsa-mir-185	Short Stature, Idiopathic, Autosomal	Finally, the authors revealed that the silencing of hsa_circ_0008870 induces low expression of MAPK1 by impairing the sponge action of miR3p, thereby inhibiting chondrocyte proliferation, hypertrophy, and endochondral ossification, which results in a short stature phenotype.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-106a	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-194	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-17	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-17	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-194	Lymphoproliferative Disorders	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
circulation_biomarker_diagnosis_up	36304469	hsa-mir-106a	Epstein-Barr Virus Infections	Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced.
other	36304467	hsa-mir-196a-1	Intestinal Diseases	3p, respectively, to play a regulatory role in the process of high-altitude hypoxia-induced intestinal injury.
genetics_knock down_suppress	36304135	hsa-mir-512	Adenocarcinoma of Lung	Overexpression of HMGA1 could restore the inhibitory effects of miR
other	36303988	hsa-mir-34a	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-122	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-1260a	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
other	36303988	hsa-mir-93	Infertility	However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively).
lncRNA target	36303447	hsa-mir-433	Glioma	3p suppressed glioma malignant progression via inhibiting NR5A2.
lncRNA target	36303271	hsa-mir-21	Nasopharyngitis	Collectively, EGF upregulates HIF-1alpha and miR-21 expression to inhibit AQP4 expression, thereby promoting the proliferation of nasal epithelial cells and the development of CRS.
transcription factor target	36303071	hsa-mir-29b	Huntington Disease	We observed age-associated alterations in chromatin accessibility between HD-MSNs and pre-HD-MSNs and identified miR-29b-3p, whose age-associated upregulation promotes HD-MSN degeneration by impairing autophagic function through human-specific targeting of the STAT3 3' untranslated region. Reducing miR-29b-3p or chemically promoting autophagy increased the resilience of HD-MSNs against neurodegeneration.
genetics_GWAS	36303006	hsa-mir-146a	Arthritis, Rheumatoid	The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied.
genetics_GWAS	36303006	hsa-mir-499	Arthritis, Rheumatoid	The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied.
genetics_overexpression_promote	36302829	hsa-mir-181b	Cardiomyopathies, Uremic	In addition, miR-181b-5p overexpression exhibited same effects with ANRIL silencing in UC.
exosome	36302748	hsa-mir-592	Melanoma	Thus, via the extracellular vesicle miR-592/PTPN7/MAPK axis, melanoma-CSCs can transfer their metastatic ability to the low-metastatic non-CSC melanoma cells.
transcription factor target	36302626	hsa-mir-23b	Vascular Diseases	These findings suggest that correcting the dysregulation of miR-23b/SMAD3 or lactate metabolism is a potential treatment for vascular diseases.
lncRNA target	36302471	hsa-mir-214	Pneumococcal Infections	5p and C1QTNF1 as potential novel targets for the treatment of PCV2 infection.
transcription factor target	36302396	hsa-mir-29a	Abortion, Habitual	Conclusion: MiR-29a may be involved in the pathogenesis of RSA by inhibiting the protein expressions of FKBP52 and VEGF, promoting the apoptosis of trophoblasts, and impairing neovascularization, resulting in placental vascular dysplasia..
lncRNA target	36301978	hsa-mir-217	Urinary Bladder Neoplasms	The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR
lncRNA target	36301978	hsa-mir-103a	Urinary Bladder Neoplasms	The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR
transcription factor target	36301034	hsa-mir-762	Lupus Vasculitis, Central Nervous System	CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE.
transcription factor target	36301034	hsa-mir-762	Lupus Erythematosus, Systemic	CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE.
lncRNA target	36301033	hsa-mir-582	Ataxia Neuropathy Spectrum	The potential diagnostic and therapeutic strategies targeting miR
other	36301024	hsa-mir-506	Obesity	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-124	Colorectal Neoplasms	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-124	Obesity	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
other	36301024	hsa-mir-506	Colorectal Neoplasms	CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression.
circulation_biomarker_diagnosis_up	36300679	hsa-mir-146a	Peripartum Cardiomyopathy 	The myocardial up-regulation of the PPCM biomarkers plasminogen inhibitor activator 1 (PAI-1) and miR-146a were prevented by both cabergoline and bromocriptine therapy.
target gene	36300495	hsa-mir-541	Uterine Cervical Neoplasms	Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling.
exosome	36299891	hsa-mir-222	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-146a	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-221	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-124	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-181a	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-126	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-93	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-21	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-181b	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-143	Cardiomegaly	5p) or in EV-BMMSCs (miR
exosome	36299891	hsa-mir-210	Cardiomegaly	5p) or in EV-BMMSCs (miR
genetics_overexpression_promote	36299824	hsa-mir-452	Breast Neoplasms	Additionally, RGS2 overexpression inhibited the malignant phenotypes of BC cells, but miR
target gene	36299503	hsa-mir-6867	Gallbladder Neoplasms	HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells.
genetics_overexpression_promote	36299488	hsa-mir-512	Pre-Eclampsia	3p-overexpressing trophoblast and PE-associated placentas.
circulation_biomarker_diagnosis_ns	36299385	hsa-mir-21	Glioblastoma	Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma.
circulation_biomarker_diagnosis_ns	36299385	hsa-mir-326	Glioblastoma	Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma.
lncRNA target	36299340	hsa-mir-28	Chronic Periodontitis	5p may participate in CP progression by targeting SPHK1 to regulate the proliferation and inflammation of PDLCs.
genetics_knock down_suppress	36299308	hsa-mir-940	Periodontitis	RESULTS: Higher abundance of circ_0099630 and TRAF6 and lower miR-940 expression were observed in periodontitis, and circ_0099630 knockdown attenuated the damage of human PDL cells (PDLCs) induced by lipopolysaccharides (LPS). CONCLUSION: Silencing circ_0099630 alleviates LPS-induced periodontal ligament cell injury via targeting miR-940/TRAF6/NF-kappaB in periodontitis.
genetics_overexpression_suppress	36298739	hsa-mir-155	Nervous Necrosis Virus Infectious	Subsequently, it was proved that overexpression of cal-miR-155 enhanced cell apoptosis with or without NNV infection and inhibited virus replication in CAB cells.
target gene	36297369	hsa-mir-34a	Liver Neoplasms	Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells.
circulation_biomarker_diagnosis_ns	36297290	hsa-mir-126	Diabetes Mellitus, Type 2	Our results revealed that HFD/STZ-induced T2D increased fasting blood glucose, ET-1, ICAM-1, E-selectin, and VIP levels, while decreasing the expression of both microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR phosphorylation.
transcription factor target	36296612	hsa-mir-145	Pituitary Diseases	The study aimed to investigate whether the protective effects of LSW against endothelial dysfunction on vascular endothelial cells (VECs) was via vascular smooth muscle cells (VSMCs)-derived miRNA-145 packaged in EVs.
other	36295655	hsa-let-7e	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
other	36295655	hsa-mir-375	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
other	36295655	hsa-mir-210	Breast Neoplasms	3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data.
exosome	36295638	hsa-mir-10b	Squamous Cell Carcinoma of Head and Neck	Conclusions: Salivary exosomal miR-10b-5p and miR
exosome	36295638	hsa-mir-486	Squamous Cell Carcinoma of Head and Neck	Conclusions: Salivary exosomal miR-10b-5p and miR
other	36295630	hsa-mir-609	Hemoglobin SC Disease	miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF.
other	36295630	hsa-mir-483	Hemoglobin SC Disease	miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF.
genetics_knock down_promote	36295086	hsa-mir-371a	Carcinoma, Hepatocellular	Moreover, gain- and loss-of-function assays and rescue assays were used to evaluate the mediated effect of BECN1-dependent autophagy on the role of miR-371a-5p in the response of HCC cells to OXA.
other	36295073	hsa-let-7	Colorectal Neoplasms	Our results sustain the relationship between the IGF axis, let-7 miRNAs, and CRC and suggest an association between the expression of these miRNAs and perineural invasion.
other	36293469	hsa-mir-145	Retinoblastoma	Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients.
other	36293268	hsa-mir-499	Severe Acute Respiratory Syndrome	These results indicate that IH stress downregulates the miR-499 in cardiomyocytes, resulting in increased levels of Reg IV and Hgf mRNAs, leading to the protection of cardiomyocytes in SAS patients.
other	36293237	hsa-mir-34b	Infertility, Male	miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia.
other	36293237	hsa-mir-34c	Infertility, Male	miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia.
other	36293154	hsa-mir-182	Choriocarcinoma	Transfecting a synthetic miR5p mimic decreased spheroid attachment of human JAr choriocarcinoma cells and E-cadherin expression (which is important for endometrial receptivity).
lncRNA target	36293154	hsa-mir-182	Embryo Loss	The miR5p/NDRG1 Axis Controls Endometrial Receptivity through the Endometrial receptivity is essential for successful pregnancy, and its impairment is a major cause of embryo-implantation failure.
other	36293110	hsa-mir-20a	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36293110	hsa-mir-101	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36293110	hsa-mir-21	Bronchiolitis Obliterans Syndrome	3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway.
other	36292960	hsa-mir-126	Diabetic Nephropathies	We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition.
other	36292960	hsa-mir-145	Diabetic Nephropathies	We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition.
genetics_GWAS	36292185	hsa-mir-34b	Thyroid Neoplasms	To date, no study has been performed to evaluate the alterations of miRNA-146ars2910164 and miRNA34b/crs4938723 polymorphism as a risk factor in the development of thyroid cancer in the Pakistani population. Similarly in miRNA-34b/c gene SNP rs4938723 was observed to have a strong association with the development of thyroid cancer as the frequency of rare allele C was higher in patients.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-92a	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-20a	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-145	Diabetic Retinopathy	5p, and miR-145 in the serum and none in the vitreous samples.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-486	Diabetic Retinopathy	5p, and miR-145 in the serum and none in the vitreous samples.
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-375	Diabetic Retinopathy	3p in the serum, with miR
circulation_biomarker_diagnosis_ns	36291965	hsa-mir-223	Diabetic Retinopathy	3p in the serum, with miR
transcription factor target	36291907	hsa-mir-181a	Retinoblastoma	We thus identified miR-181a-5p as a therapeutically exploitable target for EMT-triggered drug-resistant cancers that halted their invasion and migration and sensitized them to low-dose chemotherapy drugs.
lncRNA target	36291876	hsa-mir-214	Melanoma	This finding points to miR-214 as a potential new therapeutic target to prevent melanoma intravasation.
other	36291859	hsa-mir-338	Adenocarcinoma of Lung	3p (upregulation)-MCM4 (downregulation) pattern significantly improved the overall survival of LUAD patients (p = 0.0093).
genetics_GWAS	36291816	hsa-mir-142	Lymphoma, Large B-Cell, Diffuse	RESULTS: By proteome analyses, miR-142 knockout resulted in a consistent up-regulation of 52 but also down-regulation of 41 proteins in GC-DLBCL lines BJAB and SUDHL4.
other	36291575	hsa-mir-31	Prostatic Neoplasms	RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group.
other	36291575	hsa-mir-200b	Prostatic Neoplasms	RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group.
transcription factor target	36291177	hsa-mir-147	Arthrogryposis and ectodermal dysplasia	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
transcription factor target	36291177	hsa-mir-147	Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, X-Linked	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
transcription factor target	36291177	hsa-mir-147	Darier Disease	Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site.
other	36291136	hsa-mir-155	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-155	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-20a	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-128	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-16	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-128	Gout	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-16	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
other	36291136	hsa-mir-20a	Spinal Cord Injuries	5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-133a-1	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-425	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-429	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-30	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-620	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-1	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-93	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-210	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-339	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
circulation_biomarker_diagnosis_ns	36290970	hsa-mir-1208	Carcinoma, Pancreatic Ductal	From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC.
other	36290936	hsa-mir-21	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-21	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-21	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-141	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Pancreatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Prostatic Diseases	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290936	hsa-mir-1290	Osteosarcoma	The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290.
other	36290678	hsa-mir-4732	Cardiotoxicity	Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage.
other	36290678	hsa-mir-4732	Breast Neoplasms	Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage.
lncRNA target	36290402	hsa-mir-381	Endomyocardial Fibrosis	3p suppressed IMF deposition by inhibiting preadipocyte cell differentiation and lipid droplet deposition via the suppression of FABP3 expression in the peroxisome proliferator-activated receptor signalling pathway, whereas lncRNA4789 rescued FABP3 expression by sponging miR
target gene	36290289	hsa-mir-1275	Carcinoma, Hepatocellular	Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway.
other	36289853	hsa-mir-16	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-24	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-24	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-133a	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-210	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-16	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-21	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-21	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-155	Premature Birth	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-155	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-210	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289853	hsa-mir-133a	Cardiovascular Diseases	3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR.
other	36289702	hsa-mir-124	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-27b	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-124	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-26a	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-27b	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-126	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-26a	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-126	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-181a	Osteoporosis	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
other	36289702	hsa-mir-181a	Progeria	3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression.
lncRNA target	36289686	hsa-let-7c	Carcinoma, Renal Cell	Transfection of ccRCC cells with pre-let-7c-5p significantly inhibited proliferation, migration, invasion, and IGF1R expression.
genetics_GWAS	36289656	hsa-mir-181a	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-10a	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-499	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
genetics_GWAS	36289656	hsa-mir-499b	Abortion, Spontaneous	This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women.
other	36289615	hsa-mir-184	Keratoconus	miRNA analysis detected 16 altered species, including miR-184, responsible for familial severe keratoconus.
lncRNA target	36289596	hsa-mir-182	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-23a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-20b	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-218	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-34a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
lncRNA target	36289596	hsa-mir-99a	Lung Neoplasms	5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR
transcription factor target	36289489	hsa-mir-196b	Acute Lung Injury	CONCLUSIONS: Combination therapy with BUD and NAC ameliorates LPS-induced ALI by attenuating neutrophil recruitment through the miR-196b-5p/Socs3 molecular axis.
tissue_expression_ns	36289359	hsa-mir-4653	Carcinoma, Pancreatic Ductal	3p, decreased in the order-normal pancreatic duct, low-grade PanIN, high-grade PanIN, and PDAC.
other	36289253	hsa-mir-25	Brain Injuries	5p is a candidate treatment for septic encephalopathy.
other	36289253	hsa-mir-25	Sepsis-Associated Encephalopathy	5p is a candidate treatment for septic encephalopathy.
lncRNA target	36289101	hsa-mir-125a	Hepatitis B, Chronic	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289101	hsa-mir-125a	Hepatitis	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289101	hsa-mir-125a	Diabetic Nephropathies	Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection.
lncRNA target	36289041	hsa-mir-193a	Breast Neoplasms	The miR-193a-5p upregulation restrained chemoresistance and BC progression by the downregulation of Rap2A. CONCLUSION: All results unraveled that circ_0001667 contributed to ADM resistance and tumor development in BC via the miR-193a-5p-mediated Rap2A expression change, providing a novel regulatory mechanism for circ_0001667.
lncRNA target	36288952	hsa-mir-532	Colorectal Neoplasms	3p may serve as a potential target for treating colorectal carcinoma.
lncRNA target	36288764	hsa-mir-27a	Infertility, Female	CONCLUSION: These findings indicate a pro-survival mechanism of the MyoD/miR-27a-3p/Vangl1/Vangl2 axis for granulosa cell proliferation and suggest a novel target for the improvement of female fertility.
transcription factor target	36288761	hsa-mir-142	Uterine Cervical Neoplasms	5p acts as a tumor suppressor in cervical cancer.
lncRNA target	36288387	hsa-mir-3165	Urinary Bladder Neoplasms	Additionally, miR-3165 inhibits METTL14 expression to promote BCa progression. In addition, miR-3165 down-regulates METTL14 expression to promote BCa progression.
lncRNA target	36287177	hsa-mir-141	Colonic Neoplasms	Collectively, our findings suggest an important role of the Sohlh2/LncRNA-H19/miR-141/beta-catenin pathway in regulating colon CSC stemness and differentiation, suggesting potential therapeutic targets for colon cancer.
exosome	36287066	hsa-mir-216a	Colitis	CONCLUSIONS: Exosomal miR-216a-5p released from hypoxia-prime ASCs showed higher therapeutic efficiency than NExos in experimental colitis by promoting the M2 macrophage phenotype, which indicated that hypoxia prime may represent a promising approach to optimizing the function of ASC-derived exosomes.
genetics_knock down_promote	36286392	hsa-mir-562	Wilms Tumor	CONCLUSION: Knockdown of hsa_circ_0093741 suppresses nephroblastoma cell growth, migration and invasion by regulating the miR-562/FRS2 axis, suggesting the potential involvement of hsa_circ_0093741 in nephroblastoma progression.
other	36286245	hsa-mir-198	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-138	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-155	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-29c	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-223	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286245	hsa-mir-146a	Acquired Immunodeficiency Syndrome	Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223).
other	36286075	hsa-mir-885	Mast Cell Tumors	This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR).
genetics_GWAS	36286075	hsa-mir-21	Mast Cell Tumors	Overall, salivary miR-21 was identified as a promising tool, representing a novel approach to detecting MCT-associated epigenetic alterations in a minimally invasive manner.
other	36286075	hsa-mir-379	Mast Cell Tumors	This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR).
circulation_biomarker_diagnosis_up	36286043	hsa-mir-122	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-33a	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-21	Diabetes Mellitus, Type 2	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-33a	Atherosclerosis	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-122	Atherosclerosis	5p in serum and the liver.
circulation_biomarker_diagnosis_up	36286043	hsa-mir-21	Atherosclerosis	5p in serum and the liver.
other	36286041	hsa-mir-146a	Melanoma	Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation.
circulation_biomarker_diagnosis_ns	36286037	hsa-mir-200b	Carcinoma, Hepatocellular	Expression of the five most common HCC-involved miRNAs (miR-122, miR-200a, miR-200b, miR-221, miR-222) was examined in serum using quantitative real time PCR (qRT-PCR).
exosome	36285300	hsa-mir-21	Pancreatic Neoplasms	Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression.
genetics_knock down_suppress	36285295	hsa-mir-214	Fibrosis, Renal	3p knockdown can reduce renal interstitial fibrosis through the PTEN/PI3K/AKT pathway.
lncRNA target	36284668	hsa-mir-598	Retinoblastoma	3p inhibitor.
genetics_overexpression_promote	36284637	hsa-mir-3960	Pancreatic Carcinoma	Overexpression of miR-3960 antagonized the promotion effect of exosomes on PC cells and the TFAP2A/PTEN/AKT signaling pathway, inhibiting the growth of tumors.
other	36284632	hsa-mir-375	Carcinoma, Hepatocellular	miR-375 was obviously augmented in Exo(IL2-TAM) and HCC cells treated with Exo(IL2-TAM).
circulation_biomarker_diagnosis_down	36284455	hsa-mir-155	Herpesviridae Infections	In this study, we discovered that the expression of GATA-binding protein 3 (GATA3) was lowly expressed in KS tissues and KSHV-infected cells, while microRNA-155 (miR-155) was highly expressed in KS serum and KSHV-infected cells.
circulation_biomarker_diagnosis_up	36284396	hsa-mir-210	Ischemic Stroke	RESULTS: MiR-210 was significantly upregulated in exosomes of the MCAO plasma, and further enhanced by EA therapy.
transcription factor target	36284391	hsa-mir-9	Nervous System Diseases	MiR-9 may be a potential target of nervous system diseases.
genetics_GWAS	36284378	hsa-mir-5189	Arthritis, Rheumatoid	OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients.
genetics_GWAS	36284378	hsa-mir-595	Arthritis, Rheumatoid	OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients.
other	36284205	hsa-mir-20	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-126	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-21	Obesity	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-21	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-20	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
other	36284205	hsa-mir-126	Sleep Apnea, Obstructive	In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p&lt;0.01), miR126 (p&lt;0.001) and miR320 (p&lt;0.001), with no changes in any miRNA in patients without OSA.
lncRNA target	36283303	hsa-mir-159	Sepsis	Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response.
lncRNA target	36283303	hsa-mir-160	Sepsis	Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response.
other	36282999	hsa-mir-21	Diabetes Mellitus	Differences in the expression patterns of miR-21 during diabetic wound healing identifies the potentially critical role of therapeutic timing, for miR-21 based therapies, in driving positive outcomes for patients.
other	36281935	hsa-mir-608	Endometriosis	Based on our previous results, the aim of the present study was to explore the role of lncRNA long intergenic nonprotein coding RNA (LINC)01960201 in in vitro decidualization of endometrial stromal cells in endometriosis during the window of implantation, as well as to explore the biological function of LINC01960201, and the regulation of a disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7), hsamicroRNA (miR)760 and hsamiR608 in the decidualization of endometrial stromal cells with endometriosis.
exosome	36281649	hsa-mir-200b	Breast Neoplasms	Collectively, TXT-resistant TNBC cell-derived exosomal LINC00667 could decrease the chemosensitivity of TNBC cells to TXT via regulating miR-200b-3p/Bcl-2 axis.
genetics_overexpression_promote	36281584	hsa-mir-29a	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-205	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-93	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
genetics_overexpression_promote	36281584	hsa-mir-29	salivary gland adenoid cystic carcinoma	CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future.
lncRNA target	36281526	hsa-mir-101	Stomach Neoplasms	The lncRNA SNHG22 promotes the proliferation, migration, and invasion of GC cells via the miR
transcription factor target	36281492	hsa-mir-9a	Inflammatory Bowel Diseases	This study finds that miRNA-9a-5p targets NOX4 to suppress ROS production, which plays an important role in mucosal barrier damage in IBD.
genetics_knock down_promote	36281372	hsa-mir-23b	Carcinoma, Hepatocellular	In addition, transforming growth factor beta1 (TGF-beta1) stimulation after miR-23b-3p overexpression induced neither the mesenchymal phenotype nor migratory property of HCC cells.
other	36280145	hsa-mir-143	Premature Birth	Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth.
other	36280145	hsa-mir-199b	Premature Birth	Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth.
transcription factor target	36279730	hsa-mir-2115	Pre-Eclampsia	3p might interact with the GOT1 mRNA to downregulate its expression, further inhibiting the hypoxia-promoted ferroptosis in a PE model.
lncRNA target	36279670	hsa-mir-145	Arthritis, Rheumatoid	5p/FZD4 signal axis plays an important role in promoting the pathogenesis of RA, and CAR from CCO may inhibit RA pathology by combining the FZD4 and further blocking this signal axis.
circulation_biomarker_diagnosis_ns	36279183	hsa-mir-222	Prostatic Neoplasms	The diagnostic value of the plasma miR222-3p for discrimination of the PC patients from healthy individuals was reasonable [cut-off value (fold change relative to miR16-5p) = 1.69, area under the curve = 0.73, sensitivity = 0.75 and specificity = 0.74].
genetics_overexpression_suppress	36278816	hsa-mir-204	Gallbladder Neoplasms	In addition, overexpression of FGFR2 restored the cell malignant behavior of GBC cells inhibited by miR
genetics_knock down_suppress	36278814	hsa-mir-761	Osteoarthritis	An in vitro OA model was constructed by treating C28/I2 cells with LPS and treating them with overexpression or knockdown vector of circRNA-MSR, miR-761, and FBXO21, and autophagy inhibitor 3-MA.
other	36278683	hsa-mir-130b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
other	36278683	hsa-mir-26b	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
other	36278683	hsa-mir-4649	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL.
genetics_knock down_promote	36278455	hsa-mir-1285	Carcinoma, Hepatocellular	CONCLUSION: Our results suggested that the knockdown of lncRNA TCTN2 inhibited HCC development by regulating the miR
circulation_biomarker_diagnosis_ns	36278201	hsa-mir-23a	Ischemic Stroke	A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS.
circulation_biomarker_diagnosis_ns	36278201	hsa-mir-99a	Ischemic Stroke	A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS.
other	36277877	hsa-mir-708a	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
other	36277877	hsa-mir-148	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
other	36277877	hsa-mir-148a	Myopia	Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.
lncRNA target	36277475	hsa-mir-630	Uterine Cervical Neoplasms	CONCLUSION: Taken together, our findings indicate a novel hypoxia-induced HIF-3alpha and miR-630 regulatory feedback loop contributing to metastasis and progression of cervical cancer cells and suggest that HIF-3alpha and miR-630 might act as potential biomarkers and therapeutic targets for cervical cancer in the future.
genetics_overexpression_suppress	36277474	hsa-mir-29b	Pancreatic Carcinoma	Treatment with the exosomal inhibitor (GW4869) prevented an increase in miR-29b expression and recused the reduced VEGF expression and tube formation and migration abilities of HUVECs cocultured with BxPC3 and AsPC-1 cells that overexpressed miR-29b.
genetics_knock down_promote	36277152	hsa-mir-590	Osteosarcoma	In addition, MALAT1 knockdown upregulated the expression of miR
circulation_biomarker_diagnosis_ns	36277151	hsa-mir-203	Hemangioma	Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females.
circulation_biomarker_diagnosis_ns	36277151	hsa-mir-203a	Hemangioma	Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females.
other	36276993	hsa-mir-146a	Pancreatitis	By using qPCR on our cerulein-induced pancreatitis cell model, it is worth noting that the change of miR-146a-5p expression in inflammation-related miRNAs in AP was predominant. There is potential for miR-146a-5p to serve as a diagnostic marker and therapeutic nucleic acid drug for AP.
genetics_overexpression_promote	36276867	hsa-mir-590	Colorectal Neoplasms	HK2 overexpression or miR
transcription factor target	36276815	hsa-mir-44	Liver Cirrhosis	In addition, TEVs inhibited TGF-beta1 signaling and miR-44 in TEVs had the potential inhibitory effect on liver fibrosis.
genetics_knock down_promote	36276300	hsa-mir-490	Osteosarcoma	3p inhibited cell progression of OS under hypoxia condition, while the effects were attenuated by KLF12 overexpression.
genetics_overexpression_suppress	36276294	hsa-mir-335	Carcinoma, Renal Cell	The overexpression of CCRK partially reversed the inhibitory effects of miR
target gene	36276285	hsa-mir-193a	Pancreatic Neoplasms	miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway.
exosome	36276272	hsa-mir-613	Breast Neoplasms	Exosome-Mediated Transfer of miR-3613-5p Enhances Doxorubicin Resistance by Suppression of PTEN Expression in Breast Cancer Cells.
other	36276146	hsa-mir-16	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-let-7c	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-mir-26a	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
other	36276146	hsa-mir-17	Biliary Tract Neoplasms	5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC.
genetics_knock down_promote	36276139	hsa-mir-200b	Colorectal Neoplasms	Collectively, the loss of exosomal miR-200b-3p in hypoxia CAFs reduced the sensitivity to 5-FU in CRC by targeting HMGB3.
other	36276078	hsa-mir-223	Carcinoma, Non-Small-Cell Lung	MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
lncRNA target	36275896	hsa-mir-409	Cardiomyopathies	3p promotes cardiac fibrosis at least partially through Gpd1.
other	36275894	hsa-mir-451b	Pulmonary Disease, Chronic Obstructive	BACKGROUND: A previous study identified miR-451b as a potential biomarker in smoker with or without chronic obstructive pulmonary disease (COPD). However, the function and molecular mechanisms of miR-451b in the pathogenesis of COPD remain elusive.
exosome	36275890	hsa-mir-124	Psoriasis	miR-124-3p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL-17A Stimulation in Psoriasis.
target gene	36275636	hsa-mir-361	Colorectal Neoplasms	ALDH1A3-Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFbeta Signaling via Sponging miR-361-5p.
transcription factor target	36275459	hsa-mir-203a	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
transcription factor target	36275459	hsa-mir-192	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
transcription factor target	36275459	hsa-mir-148a	Colorectal Neoplasms	The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0.
other	36275122	hsa-mir-130b	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-5100	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-598	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
lncRNA target	36275122	hsa-mir-1307	COVID-19	3p play a critical role in SARS-CoV-2 infection, including via effects on disease progression and severity.
other	36275122	hsa-mir-505	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-34a	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-129	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-181a-2	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-34c	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
other	36275122	hsa-mir-193a	COVID-19	5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection.
lncRNA target	36274974	hsa-mir-7847	Sepsis	Our experiments demonstrate that IL17-RA-1 attenuates the sepsis response through the miR3p/MAPK pathway, and this competing endogenous RNA (ceRNA) network may be a potential approach to predict and combat sepsis.
lncRNA target	36274500	hsa-mir-501	Stomach Neoplasms	3p facilitated cell proliferation, migration, and invasion, while inhibiting cell apoptosis in GC by targeting TM4SF1.
other	36274491	hsa-mir-3173	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-629	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-1343	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
other	36274491	hsa-mir-9	Lung Diseases	"3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies."
transcription factor target	36274382	hsa-mir-1	Bacterial Infections	Moreover, interventions of miRNA-31 expressions via administration of miRNA-31 agomir reduces lung pathology and bacilli burdens via inducing up-regulation of gene sets involved in biological processes of defense response or cellular and chemical homeostasis in lungs.
other	36274378	hsa-mir-433	Colorectal Neoplasms	3p/E2F3 forms a positive loop which might become a potential biomarker in CRC.
circRNA target	36274319	hsa-mir-146a	Inflammation	Specifically, circRNA-05280 can regulate the level of apoptosis and inflammation of mammary gland by binding miR-146a and releasing the expression of miR-146a on target gene IRAK1.
other	36274229	hsa-mir-223	Granulomatous Disease, Chronic	We engineered lentiviral vectors (LVs) carrying a universal promoter (EF1a) and two myeloid-specific promoters (miR223 and CD68) to drive the expression of green fluorescence protein (GFP) or CYBB, one of the key defective genes causing CGD.
genetics_knock down_suppress	36274134	hsa-mir-10	Osteosarcoma	CONCLUSION: PCED1B-AS1 knockdown may inhibit OS cell proliferation and movement by regulating miR-10 gene methylation.
transcription factor target	36273900	hsa-mir-1281	Osteosarcoma	Hence, our findings suggested that CTB-1 inhibited the cell growth, invasion, and migration of OS by upregulating miR-1281 and inhibiting PPIF expression, thereby providing a possible target drug for OS treatment.
genetics_knock down_promote	36273755	hsa-mir-581	Carcinoma, Hepatocellular	Over-expression or knockdown of miR-581 could alter cell phenotypes caused by Lnc-COX7C-5 in HCC.
genetics_overexpression_promote	36273455	hsa-mir-133a	Adenocarcinoma of Lung	However, the promoting effects of GINS4 overexpression on LUAD could be offset by miR-133a-3p overexpression.
lncRNA target	36273140	hsa-mir-370	Ovarian Neoplasms	CONCLUSION: circ_0025033 might promote ovarian cancer progression via hsa_miR
genetics_knock down_promote	36273122	hsa-mir-103a	Carcinoma, Hepatocellular	Overexpression of EVA1A significantly attenuated the cancer-promoting effects of miR-103a-3p in HCC cells, while knockdown of EVA1A alleviated the mitochondrial dysfunction and apoptosis caused by miR-103a-3p inhibition.
other	36273030	hsa-mir-548	Cakut	Additionally, miR-548 family members have shown substantial enrichment in rare CNVs in CAKUT.
lncRNA target	36272469	hsa-mir-22	Colorectal Neoplasms	3p and plumbagin reduced colony formation and caused apoptotic cell death (detected by Annexin V/PI dual staining), possibly through increased ROS (detection by Dihydroethidium staining) and decreased MMP (detection by MitoTracker Orange staining) in CRC cells.
other	36272464	hsa-mir-142	Hematologic Diseases	In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers.
other	36272464	hsa-mir-142	Siderosis	In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers.
transcription factor target	36272206	hsa-mir-210	Cardiomyopathies	3p facilitated the proliferation of myocardial cells in H/R-treated H9C2 cells by suppressing TFR-mediated ferroptosis, which provided new methods to treat H/R-induced myocardial injury.
other	36272177	hsa-mir-184	Adenocarcinoma of Lung	Finally, the circCENPF/hsa-miR-184 axis was identified as the most promising upstream regulatory pathway of HOXC9 in lung adenocarcinoma.
circulation_biomarker_diagnosis_up	36272155	hsa-mir-122	Intracranial Aneurysm	5p and KLF6 related plasmids was to figure out their roles in cell growth.
genetics_overexpression_promote	36272153	hsa-mir-15	Osteosarcoma	However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells.
genetics_overexpression_promote	36272153	hsa-mir-15a	Osteosarcoma	However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells.
lncRNA target	36272152	hsa-mir-650	Ovarian Neoplasms	The present study investigated the role of miR-650 in ovarian cancer by targeting Kruppel-like factor 12 (KLF12). Unlike miR-650, KLF12 showed a substantial up-regulation in ovarian cancer tissues and cell lines.
lncRNA target	36272150	hsa-mir-873	Osteosarcoma	5p/KLF5 axis confers vital effect on the occurrence and progression of OS, thus providing possible guidance for the clinical treatment of OS.
other	36271618	hsa-mir-206	Myocardial Ischemia	3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia.
other	36271618	hsa-mir-208a	Myocardial Ischemia	3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia.
other	36271413	hsa-mir-185	Leukemia, Lymphocytic, Chronic, B-Cell	Besides, the expression of circ_0002078 and TCF7L1 were significantly elevated and miR3p was obviously decreased in CLL patients.
genetics_GWAS	36270583	hsa-mir-21	Spinal Cord Injuries	This study aims to develop a type of genetically engineered miR21-loaded exosomes that can be entrapped in collagen-I (Col-I) scaffold to repair SCI.
other	36270453	hsa-mir-196c	Myocardial Reperfusion Injury	The mir-196c-3p mimic (mimics) and photothermal nanoparticles (BTN) were co-encapsulated in an injectable Gel (mimics Gel/BTN) with NIR-II light-triggered release.
circulation_biomarker_diagnosis_down	36270080	hsa-mir-155	Carcinoma, Non-Small-Cell Lung	Herein, employing miRNA-155 as a target, a novel integrated concentration and determination system of exosomes (ICDSE) was fabricated for the targeted enrichment of exosomes from the plasma of patients with non-small cell lung cancer and instant downstream analysis of exosomal miRNA.
other	36269619	hsa-mir-4756	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-10a	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-221	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
other	36269619	hsa-mir-192	COVID-19	3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses.
lncRNA target	36269529	hsa-mir-425	Osteosarcoma	5p/HMGB2 regulatory axis is a promising target in treating human OS.
lncRNA target	36269411	hsa-mir-4443	Rhabdomyosarcoma	In this study, through experimental verification, we found miR-4443 to be downregulated in cells infected with EV71.
lncRNA target	36269304	hsa-mir-7977	Diabetes Mellitus	Taken together, these findings suggest GO may be a superior auxiliary material for Ad-MSCs to facilitate diabetic wound healing via the Linc00324/miR-7977/STK4 pathway.
lncRNA target	36269211	hsa-mir-128	Neurotoxicity Syndromes	3p/PGC-1alpha axis may be a therapeutic target for PBDE-47 neurotoxicity.
genetics_overexpression_promote	36269185	hsa-mir-92a	Retinal Neovascularization	RESULTS: The overexpression of miR-92a-3p inhibited the development of retinal superficial vascular plexus and deep vascular plexus, decreased the expression of Ki67, and increased the expression of cleaved caspase-3 in isolectin B4-labeled retinal vascular ECs.
transcription factor target	36269185	hsa-mir-92a	Retinal Diseases	CONCLUSIONS: The miR-92a-3p could affect retinal angiogenesis by targeting SGK3 pathway, suggesting that miR-92a-3p may be a potential anti-angiogenic factor for retinal vascular disease.
transcription factor target	36269039	hsa-mir-29c	Stomach Neoplasms	To sum up, miR-29c-3p/MEST signaling pathway suppressed formation of malignant phenotypes of GC, and targeting the signaling pathway may be a new method for treating GC.
circRNA target	36268878	hsa-mir-145	Squamous Cell Carcinoma of Head and Neck	CONCLUSION: circGOLPH3 exerted pro-oncogenic effects through the miR
other	36268280	hsa-mir-143	Adenocarcinoma of Lung	We also identified the lncRNA UCA1/miR3p/CDK1 regulatory axis in LUAD.
genetics_overexpression_suppress	36268275	hsa-mir-22	Colorectal Neoplasms	3p inhibition or FSTL1 overexpression could offset the inhibition of TRPM2-AS downregulation on CRC cells.
other	36268199	hsa-mir-450b	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268199	hsa-mir-155	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268199	hsa-mir-1249	Diabetic Retinopathy	CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p.
other	36268034	hsa-mir-585	Stomach Neoplasms	CONCLUSIONS: In conclusion, this study uncovered miR5p impedes gastric cancer proliferation and metastasis by orchestrating the interactions among CREB1, MAPK1 and MITF.
transcription factor target	36268033	hsa-mir-125b	Liver Failure	AIMS: To explore the role and mechanism of miR-125b-5p in the development of liver failure. CONCLUSION: Upregulation of miR-125b-5p can alleviate acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway, and regulation of miR-125b-5p may serve as an alternative intervention for liver failure.
lncRNA target	36267915	hsa-mir-103	Acquired Immunodeficiency Syndrome	We reveal that miRNA-103 mimics, as well as Nutlin-3, an inhibitor of Mdm2-mediated p53 degradation, decrease CCR5-dependent HIV-1 infection.
lncRNA target	36267843	hsa-mir-411	Hemangioma	CONCLUSION: DSCAM-AS1 expedited HA progression via miR5p/TPD52 pathway, which provided a novel therapeutic option for HA treatment.
transcription factor target	36267816	hsa-mir-377	Heart Failure	Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway.
transcription factor target	36267816	hsa-mir-377	Sepsis	Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway.
other	36267811	hsa-mir-124	Myocardial Infarction	3p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated.
lncRNA target	36267792	hsa-mir-671	Thyroid Cancer, Papillary	In summary, circ_0001658 is a carcinogenesis-associated circRNA that regulates PI3K/AKT signaling via the miR
other	36267723	hsa-mir-423	Stomach Neoplasms	The lncRNA TERC promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-423-5p to regulate SOX12 expression.
transcription factor target	36267717	hsa-mir-16	Colorectal Neoplasms	CONCLUSIONS: This is the first study to show that amentoflavone inhibits CRC EMT via the miR-16/HMGA2/beta-catenin pathway.
circulation_biomarker_prognosis_up	36267307	hsa-mir-18a	Esophageal Squamous Cell Carcinoma	Peripheral blood (PB) miR-18a-5p and ATM levels in these participants were quantified via qRT-PCR, and the correlations of the two genes with ESCC patients' clinicopathological characteristics were investigated.
genetics_overexpression_suppress	36267095	hsa-mir-19b	Osteoarthritis	In this study, miR-19b-3p was downregulated in osteoarthritic cartilage tissues and IL-1beta-stimulated primary chondrocytes, and miR-19b-3p overexpression reversed the inhibitory effect of IL-1beta on cell viability, the promotion effects of apoptosis, inflammatory factor secretion and extracellular matrix degradation, whereas the opposite effect was observed with miR-19b-3p inhibitor.
exosome	36266968	hsa-mir-155	Mite Infestations	These results demonstrate that the niche factors in TAME, such as exosomal miRNA-155, regulate the function and polarity of macrophages to facilitate tumor progression.
circulation_biomarker_diagnosis_ns	36266728	hsa-mir-195	Carcinoma, Renal Cell	5p), PDCD5, HDAC3, and serum glucocorticoid-inducible kinase 1 (SGK1) was determined by RT-qPCR and Western blot analysis.
lncRNA target	36266695	hsa-mir-874	Osteosarcoma	CONCLUSION: LncRNA CASC9 promotes cell proliferation and invasion in OS via miR3p/SOX12 axis.
other	36266590	hsa-mir-71	Echinococcosis	Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354).
other	36266590	hsa-let-7	Echinococcosis	Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354).
lncRNA target	36266384	hsa-mir-148a	Squamous Cell Carcinoma of Head and Neck	Finally, via upstream prognosis-related microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) prediction and co-expression analysis, we built an immune-related ceRNA network (LINC00052/hsa-miR-148a-3p/PLAU) related to HNSCC patient prognosis.
circulation_biomarker_diagnosis_up	36265417	hsa-mir-29	Pulmonary Fibrosis	In human peripheral blood from IPF patients decreased miR-29 concentrations were associated with increased mortality in two cohorts potentially identified as a target population for treatment.
genetics_knock down_promote	36265392	hsa-mir-802	Squamous Cell Carcinoma of Head and Neck	miR-802 overexpression reduced the malignant potential of OSCC cells largely by down-regulating MYO6.
transcription factor target	36264388	hsa-mir-21	Osteoarthritis	We compare the efficacy of two treatments, MSC with their miR-21 inhibited through lentiviral transfection and their EV, against inflammation in a new OA animal model.
other	36264136	hsa-mir-616	Vasculitis, Central Nervous System	ABRA showed higher levels of long noncoding RNAs and miR-616.
other	36264049	hsa-mir-106b	Ovarian Neoplasms	Up-regulation of oxidized low-density lipoprotein receptor 1 correlates with decreased miR-106b-5p, miR-93-5p, miR-3129-5p, miR-199b-3p, and miR-4465, higher recurrence rate, and poor prognosis in ovarian cancer.
lncRNA target	36263453	hsa-mir-212	Colorectal Neoplasms	CONCLUSION: CRNDE led to the deterioration of impairment on cognition induced by ISO through suppressing miR5p expression and promoting neuroinflammation.
lncRNA target	36263172	hsa-mir-607	Esophageal Squamous Cell Carcinoma	In the section of mechanism experiments, hsa_circ_0003823 regulated CRISP3 by targeting microRNA-607 (miR-607) to promote progression of ESCC. Conclusions: In this study, we elucidated the function of hsa_circ_0003823 and its role in promoting tumor progression, metastasis and Apatinib resistance of ESCC through miR-607/CRISP3 axis.
genetics_overexpression_promote	36263050	hsa-mir-210	Osteoarthritis	3p overexpression in ECs via adeno-associated virus (AAV) alleviated cartilage degradation, suppressed the type 17 immune response and relieved symptoms by attenuating subchondral Emcn(+) vasculature and subchondral bone remodeling.
genetics_knock down_suppress	36262998	hsa-mir-26a	Esophageal Neoplasms	MiR-26a-5p inhibitor can dramatically limit the ability of LINC00240 knockdown on plate colony formation and relocation of esophageal cancerous cells was demonstrated in colony formation and migration experiments. CONCLUSION: LINC00240 expression is elevated in esophageal cancerous tissues, and knocking down LINC00240 decreases esophageal cancer cell proliferation, clone formation, invasion, and migration via miR-26a-5p.
genetics_knock down_suppress	36262967	hsa-mir-1236	Carcinoma, Hepatocellular	Finally, we found that knockdown of miR
other	36262826	hsa-mir-15a	Endometriosis	This study aims to uncover the role of long non-coding RNA BRAF-activated non-protein coding RNA (lncRNA BANCR)-mediated competing endogenous RNA mechanism in endometrial stromal cell (ESC) proliferation and invasion in EM by regulating miR-15a-5p/TRIM59.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-184	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-16	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
circulation_biomarker_diagnosis_up	36262825	hsa-mir-15b	Ischemic Stroke	5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software.
lncRNA target	36262353	hsa-mir-875	Osteosarcoma	Targeting the LINC00909/miR
lncRNA target	36262350	hsa-mir-216	Colorectal Neoplasms	The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC.
lncRNA target	36262350	hsa-mir-216b	Colorectal Neoplasms	The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC.
lncRNA target	36262285	hsa-mir-625	Urinary Bladder Neoplasms	OBJECTIVE: This study further explored LINC00958's role in promoting tumor angiogenesis (AG) and oxidative stress (OS) development by inhibiting BC cell autophagy through sponge adsorption of miR
genetics_overexpression_promote	36262247	hsa-mir-1182	Colorectal Neoplasms	FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells.
transcription factor target	36262165	hsa-mir-153	Cardiomegaly	In short, Gm43843 promotes cardiac hypertrophy via miR
lncRNA target	36261179	hsa-mir-194	Gallbladder Neoplasms	CONCLUSIONS: SNHG1 silencing suppressed the viability, proliferation and invasion of GBC cells via targeting miR
lncRNA target	36261177	hsa-mir-141	Pneumonia, Mycoplasma	CONCLUSIONS: MALAT1-201 derived from MSC-Ex regulated the proliferation, apoptosis and migration of HTR8-Svneo cells by targeting miR-141, which indicated a promising therapeutic target for PE.
other	36261176	hsa-mir-145	Colonic Neoplasms	3p negatively modulated the expression of CDK1, thus attenuating the oncogenic effects produced by CDK1 in CC.
lncRNA target	36261079	hsa-mir-144	Schizophrenia	In conclusion, this study revealed that icariin may have therapeutic effects on schizophrenia-like disorders via regulating the miR3p/ATP1B2/mTOR signalling, suggesting that icariin has potential to become an antipsychotic drug.
other	36261031	hsa-mir-3917	Lung Neoplasms	miR-3917 is highly expressed in lung cancer tissues and M2-Ex. M2-Ex can transfer miR-3917 into lung cancer cells and promote lung cancer progression, providing theoretical basis for the diagnosis and effective treatment of lung cancer.
genetics_overexpression_promote	36260870	hsa-mir-126	Adenocarcinoma of Lung	The overexpression of miR
genetics_overexpression_promote	36260870	hsa-mir-1	Adenocarcinoma of Lung	The overexpression of miR
lncRNA target	36260520	hsa-mir-299	Carcinoma, Hepatocellular	Matrine stimulates HCC cell apoptosis and represses the process of EMT and stemness through the miR
genetics_overexpression_promote	36260266	hsa-mir-633	Stomach Neoplasms	Overexpression of miR-633 inhibits the proliferation and migration of GC cells and induces apoptosis and cell cycle arrest at the in G(1) phase.
circulation_biomarker_diagnosis_up	36259475	hsa-mir-21	Hypertension	We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1).
circulation_biomarker_diagnosis_up	36259475	hsa-mir-222	Hypertension	We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1).
genetics_GWAS	36258913	hsa-mir-499	Carcinoma, Non-Small-Cell Lung	SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects.
genetics_GWAS	36258913	hsa-mir-196a	Carcinoma, Non-Small-Cell Lung	SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects.
circulation_biomarker_diagnosis_ns	36258850	hsa-mir-149	Sleep Apnea, Obstructive	This study aimed to examine the serum expression of microRNA
circulation_biomarker_diagnosis_ns	36258850	hsa-mir-149	Obesity	This study aimed to examine the serum expression of microRNA
circulation_biomarker_diagnosis_ns	36258728	hsa-mir-326	Platelet Storage Lesion	Differential miRNA-326 and its target gene, Bcl-xL and Bak, expression levels at different points of platelets storage are promising tools as biomarkers for platelets undergoing PSL in blood banks.
other	36257575	hsa-mir-124	Irritable Bowel Syndrome	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
other	36257575	hsa-mir-124	Visceral Hypersensitivity	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
other	36257575	hsa-mir-124	Cancer-Associated Cachexia	MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats.
lncRNA target	36257574	hsa-mir-152	Depression	PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR
lncRNA target	36257574	hsa-mir-152	Chronic Pain	PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR
genetics_overexpression_promote	36257404	hsa-mir-26a	Diabetic Nephropathies	We determined that miR-26a-5p overexpression ameliorated podocyte injury in DN via binding to 3'-UTR of Trpc6, as evidenced by the markedly reduced activity of luciferase reporters by miR-26a-5p mimic.
lncRNA target	36255597	hsa-mir-140	Esophageal Neoplasms	In addition, DGE identified target genes of miR
lncRNA target	36255069	hsa-mir-513a	Carcinoma, Hepatocellular	These findings unraveled that circ_0003998 elevated 5-FU resistance in HCC by sponging miR-513a-5p to upregulate the level of ARK5, indicating that circ_0003998 might be used as a target to improve 5-FU therapy for HCC.
genetics_knock down_suppress	36255068	hsa-mir-543	Ovarian Neoplasms	Circ_0026123 functionally targeted miR-543, and knockdown of miR-543 reversed the impacts of circ_0026123 deficiency on DDP sensitivity and the malignant behaviors of DDP-resistant OC cells. RAB1A was a target of miR-543, RAB1A overexpression attenuated the inhibitory functions of miR-543 on DDP resistance and the malignant phenotypes of DDP-resistant OC cells.
lncRNA target	36255066	hsa-mir-128	Squamous Cell Carcinoma of Head and Neck	Further research is underway to understand how miR3p regulates oncogenesis in TSCC via MAP2K7 and associated pathways.
other	36254861	hsa-mir-199a	Myocardial Reperfusion Injury	Recent studies have revealed that miR-199a-5p participates in the process of myocardial I/R injury, but the precise roles and molecular mechanisms of miR-199a-5p in myocardial I/R injury remain not well-studied. Herein, the present study aimed to explore the function and mechanisms by which miR-199a-5p regulates whether miR-199a-5p contributes to ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reoxygenation (OGD/R) injury, an in vitro model of myocardial I/R injury focusing on Akt/eNOS signaling pathway.
transcription factor target	36254861	hsa-mir-199a	Hypoxia-Ischemia, Brain	In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway.
lncRNA target	36254861	hsa-mir-199a	Siderosis	In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway.
transcription factor target	36254623	hsa-mir-371a	Neoplasms, Germ Cell and Embryonal	Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression.
transcription factor target	36254623	hsa-mir-371a	Seminoma	Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression.
other	36254341	hsa-mir-184a	Angioedemas, Hereditary	AKT2, the mRNA regulated by the differentially-expressed miR-184A, was also associated with HAE attacks.
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-4530	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-125a	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
circulation_biomarker_diagnosis_ns	36254252	hsa-mir-92a-2	Pancreatic Carcinoma	Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a
other	36254230	hsa-mir-192	Carcinoma, Hepatocellular	RESULT: CARMN was considered to be the potential upstream lncRNA for the hsa-miR5p/LOXL2 axis in HCC.
transcription factor target	36254157	hsa-mir-181d	Optic Nerve Injuries	CONCLUSION: miR-181d-5p can protect against the deterioration of TON by inhibiting RGCs death, astrocyte development, oxidative stress, and inflammation by targeting NFIA.
lncRNA target	36254053	hsa-mir-92a	Carcinoma, Non-Small-Cell Lung	To assess the potential prognostic value of miR-92a as a new biomarker in non-small cell lung cancer (NSCLC) via clinical evaluation, a total of 100 patients with NSCLC admitted to the Respiratory and Intensive Care Department of Suining Central Hospital in Sichuan Province between August 2007 and April 2020 were retrospectively analyzed.
exosome	36253857	hsa-mir-493	Asthma, Allergic	5p, thus DC-derived exosomal miR
genetics_knock down_promote	36253542	hsa-mir-1270	Adenocarcinoma of Lung	We show that the loss of miRNAs (miR)
genetics_overexpression_promote	36252912	hsa-mir-451a	Thyroid Cancer, Papillary	Overexpression of DCBLD2 and AKT1 could restore the effect of miR-451a on PTC cells.
other	36252562	hsa-mir-138	Muscular Atrophy, Spinal	Silencing of miRNA-138 increased neuronal apoptosis and spinal cord atrophy significantly.
genetics_knock down_suppress	36252562	hsa-mir-138	Myelodysplastic Syndromes	Comparatively, knockdown of miRNA-138 downregulated Shh levels in myelodysplastic regions.
circulation_biomarker_diagnosis_ns	36252485	hsa-mir-214	Hashimoto Disease	LINC00842 functioned as a miR-214 sponge in HT patients and thyroid epithelial follicular cells. These findings concluded that AMIO-drove XBP1s aggravated endoplasmic reticulum stress and apoptosis in HT via modulating LINC00842/miR-214/FASL axis, providing a new sight for the therapeutic strategy of AMIO-induced HT.
genetics_knock down_suppress	36252478	hsa-mir-450b	Acute Lung Injury	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_suppress	36252478	hsa-mir-450b	Systemic Inflammatory Response Syndrome	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_suppress	36252478	hsa-mir-450b	Sepsis	CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
genetics_knock down_promote	36252429	hsa-mir-335	Ischemic Stroke	CONCLUSION: Circ_0101874 knockdown alleviated OGD-induced neuronal cell injury by suppressing PDE4D via regulating miR
transcription factor target	36252394	hsa-mir-26a	Endometritis	miR-26a and MAP3K8 may be a promising biomarker and therapeutic target for dairy cow endometritis.
lncRNA target	36252156	hsa-mir-377	Esophageal Squamous Cell Carcinoma	The results suggest that the molecular targeting of the lncRNA NEAT1 and miR-377/E2F3 axis could prove beneficial in the management of esophageal cancer.
genetics_knock down_suppress	36252137	hsa-mir-1249	Hypertension, Pulmonary	In rats, the repression of microR-1249 in eEVs by microR-1249 inhibitor, histone deacetylase 10 overexpression, or calcium-sensing receptor knockout profoundly inhibited the proliferative capacities and diminished apoptosis-resistance of pulmonary artery smooth muscle cells and pulmonary hypertension development in rats intravenously administrated with eEVs preparation from cigarette smoke extract-treated pulmonary artery endothelial cells. CONCLUSIONS: Cigarette smoke-enriched microR-1249 in endothelial extracellular vesicles facilitates the hyperproliferative and antiapoptotic status of pulmonary artery smooth muscle cells promoting pulmonary hypertension evolution through the inhibition of histone deacetylase 10-NFkappaB-calcium-sensing receptor cascade.
circulation_biomarker_prognosis_up	36251659	hsa-mir-1246	Dengue	CONCLUSION: Our study indicated that circulating miRNAs, especially miR
genetics_overexpression_promote	36251494	hsa-mir-450b	Squamous Cell Carcinoma of Head and Neck	miR-450b was found to be overexpressed in OSCC animal samples, HNSCC samples and human OSCC cells.
circulation_biomarker_diagnosis_up	36251230	hsa-mir-502	Alzheimer Disease	Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD.
circulation_biomarker_diagnosis_up	36251230	hsa-mir-200a	Alzheimer Disease	Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD.
transcription factor target	36251141	hsa-mir-19b	Arthritis, Rheumatoid	GA upregulated miR-19b-3p expression, downregulated RAF1 expression, inhibited ERK1/2 phosphorylation, induced MH7A cell apoptosis and suppressed MH7A cell invasion and migration (P&lt;0.05 or P&lt;0.01).
other	36250950	hsa-mir-149	Stomach Neoplasms	Rescue assays indicated that circBGN regulates GC cell proliferation and invasion by upregulating miR5p/IL6 axis output.
circulation_biomarker_diagnosis_up	36250874	hsa-mir-21	Hypoxia	To test this hypothesis, we exposed male rats to 6 h of 12% O(2) and measured circulating levels of ET-1 and miR-21, pre, during, and posthypoxia.
genetics_knock down_suppress	36250827	hsa-let-7c	Abortion, Habitual	3p, and miR-let-7c expression levels in plasma samples of patients with idiopathic recurrent pregnancy loss (iRPL) and healthy subjects and to evaluate their potential diagnostic value in diagnosis of iRPL.
genetics_overexpression_promote	36250561	hsa-mir-499	Angelman Syndrome	5p overexpression could promote the proliferation and migration of MOVAS.
other	36250561	hsa-mir-499	Cardiovascular Diseases	The miR5p/SOX6 axis may present a promising therapeutic implication for the prevention and treatment of cardiovascular diseases.
genetics_overexpression_promote	36250558	hsa-mir-186	Myocardial Infarction, Acute	Rescue experiments revealed that miR-186 overexpression or YY1 suppression partially reversed the roles of ox-EVs overexpressing CLDN10-AS1 in ox-LDL-induced VEC injury.
other	36250452	hsa-mir-574	Osteosarcoma	3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS.
lncRNA target	36250437	hsa-mir-128	Epilepsy	3p attenuates penicillin-induced cell injury and inflammation in astrocytes by targeting MAPK6, thus providing a protective role in epilepsy.
lncRNA target	36250223	hsa-mir-338	Opitz GBBB Syndrome, X-Linked	3p/MEF2C is a prospective target for OS treatment.
other	36250210	hsa-mir-21	Pre-Eclampsia	The upregulation of placental miR21 abundance by placenta-specific nanoparticles loaded with agomir-miR21 during placentation interfered with PPP2R2B and activated the Hippo pathway in the placenta, leading to a PE-like phenotype. Thus, aberrant elevation of miR21 impairs EVT mobility by modulating the PP2A Bbeta/Hippo axis, which is one of the causes of PE.
other	36250208	hsa-mir-149	Colitis	3p in colon inflammation, which may serve as an attractive therapeutic tool for colitis or IBD, and even colitis-associated carcinoma.
circulation_biomarker_diagnosis_down	36250025	hsa-mir-335	Ischemic Stroke	Conclusion: Our results revealed that serum TUG1, miR-21, NBAT1, and miR-335 could be promising molecular diagnostic markers for AIS as these biomarkers could discriminate between AIS patients and healthy controls.
other	36249798	hsa-mir-143	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
other	36249798	hsa-mir-181	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
other	36249798	hsa-mir-152	Duodenal Ulcer	We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury.
lncRNA target	36249712	hsa-mir-432	Carcinoma, Non-Small-Cell Lung	circPTN regulates the malignant progression of NSCLC cells through targeting the miR
other	36249345	hsa-mir-185	Cataract, Congenital Zonular, with Sutural Opacities	Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs.
other	36249345	hsa-mir-22	Cataract, Congenital Zonular, with Sutural Opacities	Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs.
genetics_knock down_promote	36248798	hsa-mir-216a	Squamous Cell Carcinoma of Head and Neck	An miR-216a-5p inhibitor reversed the effect of HCP5 knockdown on the proliferation and migration and invasive ability of LSCC cells.
lncRNA target	36248732	hsa-mir-181a	Autoimmune Diseases	Collectively, our results reveal a previously unappreciated T cell-intrinsic role of miR-181a-5p in restraining autoimmunity and may provide a potential therapeutic target for uveitis treatment.
genetics_overexpression_promote	36248732	hsa-mir-181a	Uveitis	Th17 cells overexpressing miR-181a-5p exhibited impaired ability to induce pathogenesis in an adoptive transfer model of experimental autoimmune uveitis (EAU).
target gene	36248434	hsa-mir-378	Leukemia, Myeloid	LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis.
lncRNA target	36248429	hsa-mir-511	Alzheimer Disease	CONCLUSION: Moxibustion at acupoints of the governor vessel can suppress the lncRNA Six3os1 expression, promote cell autophagy, accelerate Abeta1-42 clearance and alleviate cognitive dysfunction of AD mediated by the PI3K/AKT/mTOR signaling pathway through the lncRNA Six3os1/miR
other	36248425	hsa-mir-6511b	Lymphoma	LncHOTAIR/hsa-miR-6511b-5p/ATG7 could regulate the proliferation, apoptosis, and autophagy of Raji and BJAB lymphoma cells.
lncRNA target	36248422	hsa-mir-200	Colorectal Neoplasms	In previous mechanistic studies, we found that the miR-200s expression in CRC is associated with L-OHP sensitivity through regulation of MDR1/p-gp and the downstream c-JunN-terminal kinase (JNK) signaling pathway.
target gene	36248404	hsa-mir-338	Ovarian Neoplasms	Circ_0109046 silencing impaired the proliferation, migration, and invasion of ovarian cancer cells through negatively regulating miR-338-3p in vitro
other	36248377	hsa-mir-1248	Pituitary Adenoma, Non-Functioning	Hsa-miR-1248 showed exceptional connectivity in the ceRNA regulatory network, which could be closely related to the invasiveness of NFPAs.
epigenetics	36248294	hsa-mir-205	Parkinson Disease	MiR-205 Regulates LRRK2 Expression in Dopamine Neurons in Parkinson's Disease through Methylation Modification.
exosome	36248244	hsa-mir-106a	Glioma	However, hypoxic glioma cell-derived exosomes markedly promoted the proliferation and suppressed the apoptosis in TMZ-treated glioma cells, and miR-106a-5p inhibitor was able to abolish these phenomena.
lncRNA target	36248191	hsa-mir-652	Atherosclerosis	3p regulates the lipid metabolism of macrophages to alleviate atherosclerosis by inhibiting TP53 expression.
transcription factor target	36247625	hsa-mir-408a	Dehydration	Finally, miR408a was selected for functional analysis and demonstrated to be a negative regulator of drought response, mainly through regulation of reactive oxygen species accumulation in the maize root system.
circulation_biomarker_diagnosis_ns	36247409	hsa-mir-1	Breast Neoplasms	In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality.
circulation_biomarker_diagnosis_ns	36247409	hsa-mir-29b	Breast Neoplasms	In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-223	Diabetes Mellitus, Type 2	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-223	Periodontal Diseases	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-200b	Periodontal Diseases	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
circulation_biomarker_diagnosis_up	36247296	hsa-mir-200b	Diabetes Mellitus, Type 2	The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease.
other	36247288	hsa-mir-7706	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
other	36247288	hsa-mir-877	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
other	36247288	hsa-mir-128	Intrahepatic Cholestasis of Pregnancy	3p) may be a useful noninvasive diagnostic biomarker of IHCP.
lncRNA target	36247255	hsa-mir-223	Cardiomyopathies	Further experiments demonstrated that FGD5-AS1 modulated Akt activity to reduce myocardial injury through miR3p.
lncRNA target	36247255	hsa-mir-223	Myocardial Infarction	3p/Akt pathway is involved in AMI, suggesting that FGD5-AS1 may act as a potential biomarker and therapeutic target for AMI.
target gene	36247254	hsa-mir-145	Osteosarcoma	LncRNA UCA1 accelerates osteosarcoma progression via miR-145 and Wnt/β-catenin pathway.
genetics_knock down_suppress	36247250	hsa-mir-486a	Endometrial Hyperplasia	Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia.
genetics_knock down_promote	36247250	hsa-mir-486a	Inflammation	Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia.
circulation_biomarker_diagnosis_up	36247238	hsa-mir-197	Hypertension, Pregnancy-Induced	RESULTS: In pregnant women with PIH, serum UCA1 and HDAC2 expression was downregulated and serum miR
other	36246958	hsa-mir-335	Pulmonary Arterial Hypertension	Our work highlights the role of miR5p and calumenin in RV remodeling and may lead to the development of novel therapeutic strategies for right heart failure.
other	36246623	hsa-mir-29c	Carcinoma, Hepatocellular	The DUXAP8-miR-29c-FANCD2 and LINC00511-miR-29c-FANCD2 axes were identified as the most likely ncRNA-associated upstream regulatory axis of FANCD2 in HCC.
lncRNA target	36246567	hsa-mir-4500	Stomach Neoplasms	HEIH promotes gastric cancer development by inhibiting miR-4500.
lncRNA target	36246563	hsa-mir-96	Colorectal Neoplasms	Analysis of LINC01314 and miR-96 Expression in Colorectal Cancer Patients via METHODS: A tissue microarray (TMA) containing 76 individual colorectal tumor samples and 28 adjacent normal samples was constructed, and the expression levels of LINC01314 and miR-96 were detected by fluorescence in situ hybridization.
lncRNA target	36246560	hsa-mir-21	Respiratory Distress Syndrome	Thus, the camk2g/miR3p/lncRNA/circRNA network, CXCL10/CXCR3, and IL-17 signaling pathways might provide novel insights and targets for further studying the lung injury mechanism and clinical treatment.
circulation_biomarker_prognosis_up	36245984	hsa-mir-651	Carcinoma, Hepatocellular	RESULTS: Serum miR-3651 was found to be higher in HCC patients than in LC patients and normal persons, and it presented a sensitivity and specificity of 57.14% and 94.00%, respectively, in forecasting the occurrence of HCC in LC patients.
target gene	36245704	hsa-mir-361	Prostatic Neoplasms	lncRNA MIAT participated in prostate cancer by regulating cell proliferation and apoptosis via miR-361-3p/CCAR2 axis.
genetics_overexpression_promote	36245426	hsa-mir-377	Endometrial Neoplasms	3p, and overexpression of miR
genetics_overexpression_promote	36245214	hsa-mir-378a	Stomach Neoplasms	RESULTS: We report the first evidence that miR-378a-3p is downregulated in GC, whereas its overexpression inhibits proliferation, invasion, and migration as well as promotes apoptosis in GC cells.
genetics_overexpression_promote	36245088	hsa-mir-187	Prostatic Neoplasms	Prostate cancer cells were then exposed to BMSC-exos that were treated with either miR-187 mimic/inhibitor or CD276 overexpression for pinpointing the in vitro and in vivo effects of exosomal miR-187.
lncRNA target	36244909	hsa-mir-21	Acute Kidney Injury	CONCLUSIONS: ADSC-EVs inhibited inflammation and TEC pyroptosis and promoted TEC repair in AKI by mediating miR
lncRNA target	36244580	hsa-mir-709	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Ligustrazine targets circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.
other	36244127	hsa-mir-223	Endometriosis	Given the fact that miRNA-223 was previously shown to be upregulated in these cells and that this upregulation has been linked to epithelial-to-mesenchymal transition (EMT) during endometriosis, this study aimed to further explore the expression of miRNA-223, its effect in endometriosis, and the mechanisms underlying its effects. CONCLUSION: miRNA-223 expression decreased in endometrial SCs from endometriosis patients, which may facilitate the differential regulation of EMT during endometriosis.
other	36243928	hsa-mir-218	Pulmonary Disease, Chronic Obstructive	The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE.
other	36243928	hsa-mir-146a	Pulmonary Disease, Chronic Obstructive	The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE.
genetics_overexpression_suppress	36243896	hsa-mir-486	Colorectal Neoplasms	In CRC cell lines, demethylation and overexpression of miR
genetics_overexpression_suppress	36243896	hsa-mir-34c	Colorectal Neoplasms	In CRC cell lines, demethylation and overexpression of miR
lncRNA target	36243865	hsa-mir-610	Ovarian Neoplasms	This study further demonstrated that circ_0000144 downregulated ELK3 levels by sponging miR-610 in ovarian cancer cells. CONCLUSION: Our data indicate that circ_0000144 could enhance the carcinogenesis of ovarian cancer by specifically targeting miR-610, which may serve as a novel target for the diagnosis and prognosis of ovarian cancer.
exosome	36243800	hsa-mir-140	Ossification of Posterior Longitudinal Ligament	CONCLUSIONS: We found that exosomal miR
lncRNA target	36243708	hsa-mir-124	Cartilage Diseases	3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA.
lncRNA target	36243708	hsa-mir-124	Osteoarthritis	3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA.
other	36243683	hsa-let-7a	Esophageal Squamous Cell Carcinoma	The decrease in let-7a expression level led to the increased expression level of CCR7 in ESCC cells, consequently increasing their invasive ability and malignancy and resulting in a worse prognosis for ESCC patients.
lncRNA target	36243115	hsa-mir-186	Carcinoma, Hepatocellular	miR-186 was significantly lower while IGF2BP1 was elevated in cancerous tissues from ten HCC patients compared to five healthy controls. SIGNIFICANCE: miR-186 may exert tumor suppressor effects in HCC by repressing oncogenic lncRNAs H19, SNHG3, and FOXD2-AS1 through its effect on IGF2BP1.
lncRNA target	36242967	hsa-mir-93	Acute Lung Injury	Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI.
lncRNA target	36242967	hsa-mir-93	Sepsis	Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI.
lncRNA target	36242914	hsa-mir-23a	Achard-Thiers syndrome	Hnf4alphaos also promoted the stability of Hnf4alpha mRNA through an RNA/RNA duplex, leading to the transcriptional activation of miR-23a and miR-23a depletion was required for PGC1alpha function in hepatoprotective effects on HIRI. Together, our findings reveal that Hnf4alphaos elevation in HIRI leads to severe liver damage via Hnf4alphaos/Hnf4alpha/miR-23a axis-mediated PGC1alpha inhibition.
genetics_knock down_promote	36242728	hsa-mir-186	Carcinoma, Hepatocellular	5p-mediated anti-tumor effects in HCC cells, whereas KLF7 knockdown reversed the promotive effects of NUTM2A-AS1.
other	36242602	hsa-mir-146a	Polycythemia Vera	Thrombotic risk did not depend on JAK2 rs12343867, TERT rs2736100, OBFC1 rs9420907 SNV, however, we found a novel strong tendency towards statistical significance between the CC genotype miR-146a rs2431697 and thrombosis.
lncRNA target	36242511	hsa-mir-130a	Renal Tubular Oxidative Injury	When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated.
lncRNA target	36242511	hsa-mir-130	Renal Tubular Oxidative Injury	When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated.
circRNA target	36242088	hsa-mir-338	Osteoarthritis	CONCLUSION: Circ_0008365 alleviates IL-1beta-induced CHON-001 cell damage through the miR3p/SOX9 axis, which suggested that circ_0008365 might be a new therapeutic target for OA.
circRNA target	36241975	hsa-mir-182	Carcinoma, Hepatocellular	CONCLUSIONS: Taken together, circ_0003570 suppresses the development of HCC by modulating miR5p/STARD13 axis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-145	Acute Coronary Syndrome	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-145	Coronary Stenosis	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-143	Coronary Stenosis	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circulation_biomarker_diagnosis_ns	36241060	hsa-mir-143	Acute Coronary Syndrome	In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis.
circRNA target	36241055	hsa-mir-1183	Triple Negative Breast Neoplasms	We found that hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT.
lncRNA target	36240611	hsa-mir-155	Mucocutaneous Lymph Node Syndrome	Through the relationships of TFs and hsa-miR
lncRNA target	36240130	hsa-mir-9	Diabetes Mellitus	These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9.
lncRNA target	36240130	hsa-mir-9	Cardiomyopathies	These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9.
lncRNA target	36240080	hsa-mir-134	Seizures	These findings suggest that targeting miR-134 does not have therapeutic applications in DS.
transcription factor target	36239618	hsa-mir-155	Myocardial Reperfusion Injury	Meanwhile, SL decreased miR-155 level, inhibited M1 macrophage polarization and inflammation.
lncRNA target	36239568	hsa-mir-936	Carcinoma, Non-Small-Cell Lung	CONCLUSION: miR-936 targets GPR78 and improves the sensitivity of NSCLC cells to cisplatin via the Galphaq Rho GTPase pathway.
other	36239555	hsa-mir-516a	Carcinoma, Hepatocellular	PNPLA3 rs738409 GG carriers affect miR-516a-3P expression in HCV, and this may highlight a new mechanism in liver disease.
circulation_biomarker_diagnosis_ns	36239547	hsa-mir-4496	Esophageal Squamous Cell Carcinoma	Next, EC cells were cocultured with EVs, followed by lentivirus transduction and plasmid transfection for studying the role of TEVs-AC116025.2 in EC cells in relation to miR-4496 and SEMA5A.
lncRNA target	36239525	hsa-mir-135a	Colitis	CONCLUSION: This study shows that circSMAD4 regulates the progression of experimental colitis via the miR-135a-5p/JAK2 signaling axis and it may be a potential therapeutic target.
lncRNA target	36238993	hsa-mir-143	Triple Negative Breast Neoplasms	3p could be potential therapeutic targets for TNBC.
genetics_overexpression_suppress	36238848	hsa-mir-5590	Carcinoma, Renal Cell	Of note, overexpression of ROCK2 effectively reversed the regulatory effects of miR
target gene	36238844	hsa-mir-29a	Carcinoma, Non-Small-Cell Lung	miR-29a-3p inhibits the malignant characteristics of non-small cell lung cancer cells by reducing the activity of the Wnt/β-catenin signaling pathway.
other	36238488	hsa-mir-494	Osteosarcoma	3p, and TRPS1 might be a characteristic molecule for assessing the prognostic value of OS patients.
other	36238484	hsa-mir-146a	Campomelia Cumming type	After ECT treatment, the cognitive impairment was ameliorated in CUMS rats accomplished with decreased miR-146a-5p and increased NF-kappaB level.
lncRNA target	36238484	hsa-mir-146a	Neurotic Disorders	Finally, compared with ECT treatment, DEX injection could protect against depression-like behaviors by increasing miR-146a-5p level and inactivated NF-kappaB pathway. Overall, ECT-induced cognitive impairment in depression rats could be ameliorated by DEX injection via miR-146a-5p/NF-kappaB axis.
genetics_GWAS	36238483	hsa-mir-204	Diabetic Retinopathy	5p in order to participate in the pathogenetic process of DR.
lncRNA target	36238473	hsa-mir-223	Optic Nerve Glioma	3p plays an inhibitory role in ONG development by regulating NLRP3 to inhibit the proliferation of ONG cells and promote apoptosis.
other	36238196	hsa-mir-5120	Non-alcoholic Fatty Liver Disease	CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD.
other	36238196	hsa-mir-5120	Diabetes Mellitus, Type 2	CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD.
circulation_biomarker_diagnosis_ns	36237545	hsa-mir-23b	Colorectal Neoplasms	Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues.
circulation_biomarker_diagnosis_ns	36237545	hsa-mir-194	Colorectal Neoplasms	Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues.
other	36237258	hsa-mir-29c	Squamous Cell Carcinoma of Head and Neck	The ceRNA regulatory network MIR193BHG-miR-29c-3p-SFXN3 was identified as one of the potential biological regulatory pathways of HNSC. CONCLUSIONS: By performing ceRNA analysis, our study demonstrated that MIR193HG-miR-29c-3p-SFXN3 is significantly involved in HNSC, and this action axis markedly affect the therapeutic effect and prognosis.
genetics_GWAS	36237193	hsa-mir-146a	Diabetes Mellitus, Type 2	CONCLUSION: The results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians.
transcription factor target	36237168	hsa-mir-690	Muscular Atrophy	CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing.
transcription factor target	36237168	hsa-mir-690	Aicardi-Goutieres syndrome 5	CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing.
lncRNA target	36234731	hsa-mir-125b	Glioma	To solve this problem, we co-encapsulated DOX and endogenous tumor suppressor miR-125b into nanoparticles (NPs) by nanoprecipitation methods, and passively targeted them into glioma cells. In vitro experiments show that miR-125b and DOX can be effectively encapsulated into nanoparticles with different ratios, and by targeting YES proto-oncogene 1 (YES1), they can affect the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/p53 pathway and induce brain glioma cell apoptosis.
genetics_overexpression_suppress	36233263	hsa-mir-26a	Pulmonary Arterial Hypertension	5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs.
genetics_overexpression_suppress	36233263	hsa-mir-486	Pulmonary Arterial Hypertension	5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs.
lncRNA target	36233075	hsa-mir-203	Breast Neoplasms	Notably, miR-203 and Caveolin 1 (CAV1) have also been found to play a role in breast cancer. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the HOTAIR/miR-203/CAV1 axis, which complemented the role network of HOTAIR as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy.
lncRNA target	36232922	hsa-mir-139	Colorectal Neoplasms	3p-transfected cells revealed 29 putative targets regulated by miR
other	36232660	hsa-mir-199a	Breast Neoplasms	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-151a	Arm Lymphedema	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-199a	Arm Lymphedema	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
other	36232660	hsa-mir-151a	Breast Neoplasms	Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group.
lncRNA target	36232606	hsa-mir-221	Carcinoma, Hepatocellular	The miR-221/AEG-1 axis silencing induces apoptosis and G2/M phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, RB, and PTEN and downregulating LSF, LC3A, Bcl-2, OPN, MMP9, PI3K, and Akt in HCC cells.
other	36232605	hsa-mir-140	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-708	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-183	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
other	36232605	hsa-mir-766	Carcinoma, Non-Small-Cell Lung	3p) were obtained.
genetics_GWAS	36232465	hsa-mir-166	Plant Poisoning	qRT-PCR analysis of 29 related genes suggested that defects of the OsDRB2-miR166-OsHBs pathway could play an important role in formation of the rolled leaf phenotype of rl89, in which OsDRB2 mutation reduced miR166 accumulation, resulting in elevated expressions of the class III homeodomain-leucine zipper genes (such as OsHB1, 3 and 5) involved in leaf polarity and/or morphology development.
other	36232448	hsa-mir-181a	Glioma	Therefore, miR-181a is a unique molecule that plays an important role in gliomagenesis, and is also associated with changes in patients' quality of life.
other	36231141	hsa-mir-100	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group.
transcription factor target	36231141	hsa-mir-155	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Targeting PERV with CRISPR/Cas9 resulted in reduced expression of PERV mRNA transcripts and increased miR-155 in the Endo-EVs, and supplementing these in embryos reduced embryo attachment.
other	36231141	hsa-mir-132	Stiff-Person Syndrome	Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Cardiomegaly	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Pulmonary Fibrosis	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
circulation_biomarker_diagnosis_up	36231079	hsa-mir-34a	Diabetic Cardiomyopathies	Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes.
lncRNA target	36231079	hsa-mir-92a	Pulmonary Fibrosis	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
lncRNA target	36231079	hsa-mir-92a	Cardiomegaly	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
lncRNA target	36231079	hsa-mir-92a	Diabetic Cardiomyopathies	Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a).
other	36231008	hsa-mir-210	Diabetes Mellitus, Type 2	5p).
other	36231008	hsa-mir-210	Obesity, Morbid	5p).
other	36231008	hsa-mir-206	Obesity, Morbid	5p).
other	36231008	hsa-mir-206	Diabetes Mellitus, Type 2	5p).
other	36230970	hsa-mir-93	Colorectal Neoplasms	CONCLUSION: In summary, our result reveals the novel mechanism in which m(6)A-mediated HNF1A-AS1/IGF2BP2/CCND1 axis promotes CRC cell cycle progression, along with competitively sponging miR5p to upregulate CCND1, demonstrating its significant role in cell cycle regulation and suggesting that HNF1A-AS1 may act as a potential prognostic marker of colorectal cancer in the future.
circulation_biomarker_diagnosis_up	36230923	hsa-mir-17	Pneumonia	5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum.
circulation_biomarker_diagnosis_up	36230923	hsa-mir-193a	Pneumonia	5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum.
circulation_biomarker_diagnosis_up	36230658	hsa-mir-34a	Carcinoma, Non-Small-Cell Lung	We analyzed the expression levels and examined the clinical significance of immunoregulatory miRNAs involved in immune checkpoint regulation (miR-34a, miR-200b, miR-200c), T-cell activity (miR-155), and the function of myeloid-derived suppressive cells (MDSCs) (miR-223) or regulatory T lymphocytes (Tregs) (miR-146a), in patients with advanced NSCLC (N = 69) treated with anti-PD-1 (Nivolumab) immunotherapy as 2nd or 3rd line of treatment therapy. Our findings suggest that alterations in circulating miR-200c and miR-34a expression levels are associated with the response and outcome in patients with advanced NSCLC treated with anti-PD1 immunotherapy.
other	36229758	hsa-mir-660	Carcinoma, Non-Small-Cell Lung	Circ_0060967 facilitates proliferation, migration, and invasion of non-small-cell lung cancer cells by sponging miR-660-3p/UBN2.
circulation_biomarker_diagnosis_down	36229729	hsa-mir-147b	Leukemia, Myeloid, Acute	miR-147b was negatively correlated with MAFG-AS1 in the serum and bone narrow of AML cases.
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-483	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-1277	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
circulation_biomarker_diagnosis_ns	36229645	hsa-mir-152	Lung Neoplasms	3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA
other	36228560	hsa-mir-21	Mucocutaneous Lymph Node Syndrome	Moreover, the proposed MLN-MB could detect the miRNA-21 in complex matrixes stably.
genetics_overexpression_suppress	36228497	hsa-mir-135a	Breast Neoplasms	Overexpression of BAG3 reversed the impacts of miR-135a-5p on the malignant biological behaviors of BC cells.
lncRNA target	36228430	hsa-mir-155	Influenza in Birds	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
lncRNA target	36228430	hsa-mir-155	Newcastle Disease	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
lncRNA target	36228430	hsa-mir-155	Bursitis	In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively.
circulation_biomarker_diagnosis_up	36228356	hsa-mir-221	Depression	3p in the hippocampus and serum of O(3) treated group.
other	36228348	hsa-let-7	Head and Neck Neoplasms	In this study, we aimed to investigate polymorphic alterations of the let-7 miRNA binding site (rs61764370) in the 3'UTR region of the KRAS gene as a predictive biomarker for head and neck cancer (HNC) and to evaluate its association with clinicopathological parameters.
epigenetics	36228259	hsa-mir-130b	Pediatric Obesity	Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children.
epigenetics	36228259	hsa-mir-146b	Pediatric Obesity	Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children.
lncRNA target	36227683	hsa-mir-19a	Cerebral Infarction, Acute	Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction.
lncRNA target	36227683	hsa-mir-19a	Brain Ischemia	Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction.
circulation_biomarker_diagnosis_ns	36227679	hsa-mir-146a	Depression, Post Stroke	Compared with that of N-PSD patients, serum miR-146a-5p levels in PSD patients were significantly increased (P<0.05).
lncRNA target	36227673	hsa-mir-194	Laryngeal Neoplasms	5p could reduce the number of laryngeal cancer cells passing through the basement membrane and their invasion ability.
other	36227666	hsa-mir-34a	Neuroblastoma	This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma.
other	36227666	hsa-mir-584	Neuroblastoma	This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma.
circulation_biomarker_diagnosis_up	36227663	hsa-mir-7	Colorectal Neoplasms	It was concluded that modulation of miR-7 in rats with colorectal cancer and HP infection enables regulation of the Akt / GSK-3 beta/beta- Catenin pathway to improve serum inflammation condition and alleviate HP infection in rats, which played a better role in intervention.
genetics_overexpression_promote	36227662	hsa-mir-889	Diabetes, Gestational	The high glucose-induced human trophoblast cells HTR-8/SVneo were adopted to stimulate the GDM model in vitro (HG group) and were transfected with lentivirus to silence circ-PNPT1 (si-circ-PNPT1 group) and mimic to overexpress miR
circRNA target	36227499	hsa-mir-134	Thyroid Cancer, Papillary	5p served as a tumor repressor in PTC by targeting FSTL1.
transcription factor target	36227355	hsa-mir-181c	Sepsis	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
transcription factor target	36227355	hsa-mir-181c	Acute Kidney Injury	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
transcription factor target	36227355	hsa-mir-181c	Burns	CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI.
genetics_knock down_suppress	36227295	hsa-mir-484	Kidney Calculi	Taken together, these findings suggest that miR-484 overexpression may be a potential inhibitor of RTEC proliferation and CaOx crystallization through a VDR/FoxO1 regulatory axis, providing a novel therapeutic target for the treatment of kidney stone.
lncRNA target	36227173	hsa-mir-22	Vascular Diseases	These findings suggested that PA inhibits VSMC switch to synthetic phenotype through upregulation of miR-22 thereby inhibiting EVI1, and correcting the dysregulation of miR-22/EVI1 or PA metabolism is a potential treatment to vascular diseases.
other	36227151	hsa-mir-101	Adenocarcinoma of Lung	The most promising upstream ncRNA-associated pathway of KIF14 in LUAD was determined to be GSEC/TYMSOS-hsa-miR3p axis according to the starBase and The Cancer Genome Atlas databases.
other	36227125	hsa-mir-422a	Glioma	In this study, based on the glioblastoma microarray profiles, we identified the upstream circTOP2A, which completely bound to miR-422a and was co-expressed with the RPN2.
other	36227097	hsa-mir-200c	Diabetic Nephropathies	The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction.
other	36227097	hsa-mir-200	Diabetic Nephropathies	The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction.
exosome	36226722	hsa-let-7b	Ovarian Neoplasms	We performed coculture experiments using ID8-VEGF ovarian cancer cells to demonstrate EV-mediated propagation of tumor suppressor miRNA Let7b administered with hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles.
lncRNA target	36226520	hsa-mir-486	Gaucher Disease	5p inhibits GA inflammatory response via modulating FOXO1.
other	36226317	hsa-mir-211	Cerebral Hemorrhage	BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH.
other	36226317	hsa-mir-198	Cerebral Hemorrhage	BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH.
lncRNA target	36226250	hsa-mir-1271	Uterine Cervical Neoplasms	Overall, this study showed that FAM201A promoted cervical cancer progression and metastasis by targeting the miR5p/FLOT1 axis-induced Wnt/beta-catenin pathway.
transcription factor target	36225912	hsa-mir-10a	Acquired Immunodeficiency Syndrome	Thus, inhibition of miR-10a-5p enhanced HIV-specific CD8(+) T cell capacity in progressors.
transcription factor target	36225178	hsa-mir-505	Myocarditis	In this study, miR5p is related to MIRI pathogenesis, which provides the new possible targeted therapy in patients with MIRI.
virus_miRNA	36225172	ebv-mir-BART5	Nasopharyngeal Carcinoma	Inhibiting expression of EBV-miR-BART5-3p might reduce the risk of developing nasopharyngeal cance
lncRNA target	36224673	hsa-mir-3679	Carcinoma, Hepatocellular	Moreover, miRNA-3679 promotes the proliferation of HCC cells and inhibits their apoptosis by suppressing ZADH2.
lncRNA target	36224588	hsa-mir-155	Colonic Neoplasms	CONCLUSION: Our findings demonstrate that circPPFIA1s inhibit the liver metastasis of CRC via the miR5p/CDX1 and HuR/RAB36 pathways.
lncRNA target	36224570	hsa-mir-4306	Hypertrophy Of Ligamentum Flavum	CONCLUSIONS: Our study demonstrated that TCF7 inhibition could suppress HLF formation by modulating TCF7/SNAI2/miR-4306 feedback loop, which might be considered as a novel potential therapeutic target for HLF.
lncRNA target	36224570	hsa-mir-4036	Hypertrophy Of Ligamentum Flavum	Furthermore, miR-4036 negatively regulated by SNAI2 could negatively feedback regulate TCF7 expression by directly binding to TCF7 mRNA 3'-UTR, thus inhibiting the hyper-proliferation and fibrosis phenotype of HLF cells in vitro.
genetics_GWAS	36224531	hsa-mir-19b	Endothelial Barrier Dysfunction	METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock.
genetics_GWAS	36224531	hsa-mir-19b	Shock, Hemorrhagic	METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock.
other	36224455	hsa-mir-1226	Nasopharyngeal Neoplasms	Our results demonstrated the novel function of TUC338/miR3p/FGF2 axis in NPC progression, suggesting the potential diagnosis and therapeutics significance of TUC338 in NPC.
genetics_overexpression_promote	36224454	hsa-mir-671	Thyroid Cancer, Papillary	5p, and its overexpression relieved miR
lncRNA target	36224266	hsa-mir-145	Laryngeal Neoplasms	5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma.
lncRNA target	36224266	hsa-mir-144	Laryngeal Neoplasms	5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma.
genetics_overexpression_promote	36224238	hsa-mir-936	Prostatic Neoplasms	Furthermore, the overexpression of miR-936 suppresses the cell proliferation, cell cycle progression, cell migration, and invasion abilities of metastatic PCa PC-3 cells in vitro and tumor forming ability in vivo.
exosome	36224178	hsa-let-7a	Liver Injury	Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment.
exosome	36224178	hsa-let-7a	Acute-On-Chronic Liver Failure	Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment.
exosome	36224027	hsa-mir-22	Melanoma	Moreover, exosomes secreted by MSCs can be loaded with miR
exosome	36224011	hsa-let-7c	Prostatic Neoplasms, Castration-Resistant	CONCLUSIONS: MSC-derived exosomes could serve as a therapeutic let-7c delivery system to target CRPC.
exosome	36223498	hsa-mir-25	Lupus Nephritis	Urinary exosomal miR
exosome	36223498	hsa-mir-195	Lupus Nephritis	CONCLUSION: We analyzed and obtained a series of differential miRNAs in LN kidney tissues and suggested that urinary exosomal miR
exosome	36223498	hsa-mir-429	Lupus Nephritis	Urinary exosomal miR
lncRNA target	36222958	hsa-mir-205	Depression	Thus, MA may ameliorate depressive behavior through CREB/BDNF pathway regulated by miR-205/Cx43 axis.
exosome	36222945	hsa-mir-655	Esophageal Squamous Cell Carcinoma	OBJECTIVE: This study clarified the function of human umbilical cord mesenchymal stem cell (hUCMSC)-derived extracellular vesicle (EV)-enclosed miR
transcription factor target	36222901	hsa-mir-199a	Colitis	plantarum supplementation also suppressed CD44 expression (1.2 fold) by up regulating the expression of miR199a (1 fold) over DSS induced colitis. Our study suggests that Lactobacillus, lignin, and their synergistic treatments have protective roles against inflammatory bowel disease through changes in inflammatory cytokines, and miR 199a expression in DSS-induced colitis.
other	36222338	hsa-mir-143	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
other	36222338	hsa-mir-133a	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
other	36222338	hsa-mir-145	Lung Neoplasms	We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node).
circRNA target	36222337	hsa-mir-124	Siderosis	Both UII and ferroptosis inducer Erastin significantly promoted the expression of alpha-SMA, Collagen I and TGF-beta1 in VAFs, but circ0004372 siRNA, miR-124 mimics, SERTAD4 siRNA or Ferrostatin-1 significantly inhibited the effect of UII and Erastin on cell activation. Therefore, these results indicate that UII promotes the activation of VAFs through the circ0004372/miR-124/SERTAD4/ferroptosis pathway.
genetics_overexpression_promote	36222159	hsa-mir-1299	Carcinoma, Hepatocellular	MiR-1299 mimics, ZC3H13 overexpression or GBX2 siRNA significantly inhibited HCC cell viability, promoted apoptosis and reduced invasion; GBX2 exerted the opposite effects and could reverse the regulatory effects of miR-1299 or ZC3H13 on HCC cells.
lncRNA target	36221890	hsa-mir-367	Lung Neoplasms	3p/TFRC pathway via resibufogenin might provide novel therapeutic targets for lung cancer therapy.
lncRNA target	36221434	hsa-mir-218	Pheochromocytoma	5p and toll-like receptors (TLR4) level were examined by both quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, the potential target genes of miR
other	36221429	hsa-mir-4748	Pulmonary Disease, Chronic Obstructive	Moreover, hsa-miR-4748/CDC42/MAPK signaling pathway may contribute to the pathogenesis of COPD, providing a potential novel therapeutic strategy in COPD.
lncRNA target	36221381	hsa-mir-181c	Frontotemporal Lobar Degeneration	In FTD, SEV miRNA-181c was downregulated compared to healthy controls. SEV miRNA-181c is significantly downregulated in FTD compared to healthy controls and may mediate its effects through microglial-directed neuroinflammation and interaction with TAR DNA-binding protein 43 (TDP-43) based on pathway analysis.
circulation_biomarker_diagnosis_up	36221381	hsa-mir-21	Frontotemporal Lobar Degeneration	Using an FDR <0.2, only miRNA5p was found to have increased expression in the cerebrospinal fluid compared to plasma in a group of AD and FTD participants.
exosome	36221294	hsa-mir-214	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-217	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-423	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
exosome	36221294	hsa-mir-133a	Myocardial Infarction	Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway.
lncRNA target	36221121	hsa-mir-223	Periodontitis	CONCLUSIONS: Our study provides novel evidence that miR-223 can be induced by periodontitis and acts as a negative regulator of PDL-derived cells osteogenesis by targeting two growth factor receptors (TGFbetaR2 and FGFR2).
other	36220723	hsa-mir-2909	Breast Neoplasms	The emerging studies of miR-2909 involvement in other cancers led us to explore its role as molecular mechanistic marker in breast cancer. CONCLUSION: The results suggest that miR-2909 forms strong thermodynamically stable molecular hybridized complexes with MRE11 and RAD50 mRNAs which further strongly interacts with argonaute protein to show potential molecular mechanistic role in breast cancer.
genetics_GWAS	36219718	hsa-mir-340	Stomach Neoplasms	PRACTICAL APPLICATIONS: Gastric cancer is the third leading cause of cancer death, and genetic and epigenetic factors, including miR-340, are involved in its pathogenesis.
circulation_biomarker_diagnosis_up	36219614	hsa-mir-221	Postoperative Cognitive Complications	Our results indicate that the plasma postoperative microRNA
circulation_biomarker_diagnosis_ns	36219565	hsa-mir-21	Lung Neoplasms	We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA5p biomarker related to lung cancer.
circulation_biomarker_diagnosis_up	36219542	hsa-mir-23b	Pancreatitis, Chronic	However, the expression of plasma glutathione peroxidase (GPx3) in early-onset ICP patients was markedly lower than that in late-onset ICP patients, although the level of hsa-miR-323b-5p was lower in late-onset patients compared to the early-onset ICP group. CONCLUSIONS: The up-regulated hsa-miR-323b-5p might play a crucial role in the early-onset mechanisms of ICP by diminishing the antioxidant activity through the down-regulation of GPx3.
epigenetics	36219533	hsa-mir-106b	Osteoporosis	CONCLUSION: Hsa-miRNA-106b-5p regulates bone formation and the pathogenesis of osteoporosis by controlling TCF4, and methylation modification of TCF4 can also affect the pathogenesis of osteoporosis.
genetics_overexpression_promote	36219369	hsa-mir-485	Adenocarcinoma of Lung	5p overexpression in LUAD cells reduced their malignant behaviors, suppressed PI3K and Akt phosphorylation, and facilitated apoptosis.
target gene	36219357	hsa-mir-326	Colorectal Neoplasms	upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells.
lncRNA target	36219356	hsa-mir-491	Squamous Cell Carcinoma of Head and Neck	In summary, we draw a conclusion that circMAT2B could modulate the processes of cell proliferation, migration, invasion, and glutaminolysis of HNSCC cells partly via the miR5p/ASCT2 axis by a molecular mechanism of competing endogenous RNA (ceRNA), implying an underlying circRNA-targeted therapy for HNSCC treatment.
genetics_knock down_promote	36219353	hsa-mir-92b	Colonic Neoplasms	We detected the expression of FEZF1-AS1, miR-92b-3p, and ZIC5 via quantitative reverse transcription-PCR, transfected colon cancer cell RKO with lentivirus and conducted FEZF1-AS1 knockdown, and performed cancer-related functional assays.
genetics_GWAS	36219319	hsa-mir-429	Glioblastoma	CONCLUSIONS: Altogether, miR-429 seems to be an efficient suppressor of the ERBB genetic signaling pathway and a potential therapeutic for GBM.
transcription factor target	36217923	hsa-mir-23b	Schizophrenia	We observed significant enrichment of MBSVs in schizophrenia, depression, bipolar disorder, and anorexia nervosa, particularly in genes targeted by several miRNA families, including miR
other	36217395	hsa-mir-221	Prostatic Neoplasms	CONCLUSIONS: TOPIIA, Ki-67 and miR-221 may not predict BCR, CR or PcD in high-risk PCa patients who underwent RP at a medium-term follow-up.
circulation_biomarker_diagnosis_ns	36217380	hsa-let-7f	Pulmonary Fibrosis	Of these, let-7f-5p showed reproducibly lower level in the blood and lung of the BIPF model rat, and the expression levels of PI3K/AKT/COX2 signaling pathway genes (PIK3CA, PDK1, Akt1, IKBKA, NF-kappaB1 and COX2) were increased in the lung of BIPF model rats, suggesting that there is a potential correlation between BIPF and the PI3K/AKT/COX2 signaling pathway.
other	36217202	hsa-mir-130b	Neoplasms, Multiple Primary	MiR-130b-3p levels were significantly upregulated and positively correlated with mTORC1 signaling in multiple cancers.
lncRNA target	36217202	hsa-mir-130b	Squamous Cell Carcinoma of Head and Neck	MiR-130b-3p inhibition attenuated tumor angiogenesis and growth in an HNSCC PDX model.
circulation_biomarker_prognosis_ns	36217165	hsa-mir-519a	Stomach Neoplasms	RESULTS: The expression level of miR-519a-3p in serum exosomes was significantly higher in GC-LM patients than in patients without LM, and high expression of exo-miR-519a-3p indicates a worse prognosis.
other	36216908	hsa-mir-193a	Obesity	The most significant association among the overlapping miRNAs was with miR-193a-5p, which was shown to be associated with type 2 diabetes and hepatic steatosis in the Rotterdam Study.
other	36216575	hsa-mir-17	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	The work uncovered a critical role of the c-MYC-miR92-BIM axis in the growth and survival of CML cells.
circulation_biomarker_diagnosis_ns	36216309	hsa-mir-33a	Carcinoma, Hepatocellular	Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention.
circulation_biomarker_diagnosis_ns	36216309	hsa-mir-122	Carcinoma, Hepatocellular	Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention.
exosome	36216243	hsa-mir-361	Diabetes Mellitus	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
exosome	36216243	hsa-mir-361	Diabetic Angiopathies	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
exosome	36216243	hsa-mir-361	Obesity	In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications.
circulation_biomarker_diagnosis_ns	36216207	hsa-mir-545	Pneumonia	3p), and tumor necrosis factor receptor-associated factor 1 (TRAF1) in neonatal pneumonia serums and LPS-treated 16HBE cells.
genetics_knock down_promote	36216119	hsa-mir-513a	Esophageal Squamous Cell Carcinoma	miR-513a-3p was verified as a specific target of BBOX1-AS1 in ESCC, whereas knockdown of miR-513a-3p reversed the suppressive function of BBOX1-AS1 silencing in TE-1 cells.
lncRNA target	36216078	hsa-mir-222	Aortic Dissection	3p alleviated the symptom of AD in vivo by targeting STAT3, and inhibited stress fiber formation, abnormal migration, proliferation and apoptosis of HVSMCs induced by PDGF-BB by regulating the expression of alpha-SMA, SM22alpha, MMP2, MMP9 and p-Smad2.
transcription factor target	36215851	hsa-mir-484	Dengue	CONCLUSION: The miRNAs identified by sequencing, especially miR-484 may be the potential therapeutic targets for liver involvement in dengue patients which involves the regulation of vascular permeability and expression of inflammatory cytokines.
genetics_overexpression_suppress	36215729	hsa-mir-6838	Liver Neoplasms	6p was down-regulated in HCC tumors and overexpression of miR
genetics_overexpression_promote	36215729	hsa-mir-6838	Carcinoma, Hepatocellular	5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor.
genetics_overexpression_promote	36215729	hsa-mir-6838	Hepatitis B, Chronic	Overexpression of miR5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor.
lncRNA target	36215225	hsa-let-7f	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs were significantly differentially expressed between PRRSV-infected and mock-infected PAMs from 4 pig breeds. The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7d	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7d	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7f	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7	Lung Injury	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
lncRNA target	36215225	hsa-let-7	Porcine Reproductive and Respiratory Syndrome	The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury.
genetics_knock down_promote	36214997	hsa-mir-23b	Stomach Neoplasms	Loss of SNHG17 reduced the resistance of DDP-resistant GC cells to DDP, which was achieved through miR-23b-3p-dependent Notch2 inhibition.
circulation_biomarker_diagnosis_up	36214846	hsa-mir-451a	Myocardial Infarction, Acute	MHR and miR-451a expression were markedly elevated in plasma samples of AMI patients compared with the UAP and HC groups, but the expressions of miR
circulation_biomarker_diagnosis_ns	36214846	hsa-mir-21	Myocardial Infarction, Acute	Circulating miR
circulation_biomarker_diagnosis_up	36214846	hsa-mir-486	Myocardial Infarction, Acute	The results showed that circulating miR
other	36214767	hsa-mir-145	Carcinoma, Hepatocellular	5p or RGS3 furtherly indicated UBE2MP1 as an upstream regulator of the axis in promoting HCC cell growth and maintenance.
other	36214765	hsa-mir-143	Coronary Artery Disease	In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively).
other	36214765	hsa-mir-143	Heart Valve Diseases	In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively).
other	36214718	hsa-mir-20a	Ischemic Stroke	A rat middle cerebral artery occlusionreperfusion (MCAO/R) model was established to investigate the role of the HIF1alpha/miR20a5p/KIF5A axis in ischaemic stroke in vivo.
other	36214716	hsa-mir-92a	Hirschsprung Disease	Herein, elevated expression of miR92a and reduced expression of KLF4 were found in HSCR tissues, and their expression patterns were negatively correlated.
lncRNA target	36214714	hsa-mir-642a	Glioblastoma	This study was designed to explore the function of lncRNA MAFGAS1/miR642a5p/Notch1 in glioblastoma (GBM) cells under radiation. MAFGAS1 reduces the radiosensitivity of GBM cells via miR642a5p/Notch1 axis.
lncRNA target	36214709	hsa-mir-206	Alzheimer Disease	The ADassociated network was constructed, including 2 lncRNAs (A2MAS1 and ZNF571AS1), 1 miRNA (hsamiR206), 2 mRNAs (NOTCH3 and JAG1), and 2 pathways (notch signaling pathway and endocrine resistance). A2MAS1, ZNF571AS1, hsamiR206, NOTCH3 and JAG1 may be involved in the mechanisms of AD through notch signaling pathway and endocrine resistance.
other	36214592	hsa-mir-223	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
other	36214592	hsa-mir-484	Acute Coronary Syndrome	RESULTS: The miR-484 expression was significantly upregulated in the ACS subjects (P = .0097). CONCLUSION: The results of this study indicate that the upregulated expression of miR-484 in ACS patients might be used as a diagnostic biomarker in ACS.
other	36214592	hsa-mir-126	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
other	36214592	hsa-mir-130a	Acute Coronary Syndrome	5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD).
circulation_biomarker_diagnosis_up	36213989	hsa-mir-942	Coronary Artery Disease	RESULTS: Circ_HECW2 and TLR4 expression levels were up-regulated and miR5p expression was decreased in the serum of CAD patients and oxidized low-density lipoprotein (ox-LDL)-induced hCMECs.
circRNA target	36213989	hsa-mir-942	Cardiovascular Diseases	CONCLUSION: Circ_HECW2 could regulate ox-LDL-induced cardiovascular endothelial cell dysfunction through targeting miR5p/TLR4 axis.
lncRNA target	36213586	hsa-mir-429	Nasopharyngeal Carcinoma	CONCLUSIONS: High expression of MSC-AS1 exerted a carcinogenic effect on NPC cell growth and metastasis by inhibiting miR-429 and activating the JAK1/STAT3 pathway.
genetics_GWAS	36213264	hsa-mir-143	Diabetes Mellitus, Type 2	A functional polymorphism of microRNA-143 is associated with the risk of type 2 OBJECTIVE: To explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-101	Diabetes Mellitus	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-181c	Stroke	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-181c	Diabetes Mellitus	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
circulation_biomarker_diagnosis_up	36212996	hsa-mir-101	Stroke	CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS.
target gene	36212971	hsa-mir-28	Stomach Neoplasms	miR-28-5p's Targeting of GAGE12I Inhibits Proliferation, Migration, and Invasion of Gastric Cancer in Vitro.
genetics_overexpression_promote	36212964	hsa-mir-641	Endometrial Neoplasms	Overexpression of AP1G1 neutralized the roles of miR-641 mimic on the viability, proliferation, apoptosis, and migration of HEC-1A and HECCL-1 cells.
lncRNA target	36212960	hsa-let-7a	Atrial Fibrillation	We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF.
lncRNA target	36212960	hsa-mir-125a	Atrial Fibrillation	We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF.
target gene	36212408	hsa-mir-101	Breast Neoplasms	LncRNA SNHG6 sponges miR-101 and induces tamoxifen resistance in breast cancer cells through induction of EMT.
other	36212369	hsa-mir-96	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-159b	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-529b	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212369	hsa-mir-19	Dehydration	As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated.
other	36212136	hsa-mir-155	Endometriosis	5p-HIF1A, which may be closely related to OE development.
other	36212136	hsa-mir-34a	Endometriosis	5p-HIF1A, which may be closely related to OE development.
other	36212136	hsa-mir-93	Endometriosis	5p-HIF1A, which may be closely related to OE development.
genetics_GWAS	36212130	hsa-mir-101	Carcinoma, Hepatocellular	Our study is the first to demonstrate that besides genetic alteration and DNA methylation, AC145207.5/LINC01748-miR
transcription factor target	36211818	hsa-mir-28	Intervertebral Disc Degeneration	5p targets WWP2 to regulate nucleus pulposus cells apoptosis and then participates in the development of IDD.
other	36211602	hsa-mir-155	Asthma	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
other	36211602	hsa-mir-155	Hypersensitivity, Immediate	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
other	36211602	hsa-mir-155	Dermatitis, Atopic	MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis.
circulation_biomarker_diagnosis_up	36211468	hsa-mir-26a	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
circulation_biomarker_diagnosis_up	36211468	hsa-mir-199a	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
circulation_biomarker_diagnosis_up	36211468	hsa-mir-29c	Carcinoma, Hepatocellular	The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%).
lncRNA target	36211460	hsa-mir-19b	Infertility, Male	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19a	Oligospermia	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19b	Oligospermia	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
lncRNA target	36211460	hsa-mir-19a	Infertility, Male	Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters.
circRNA target	36210730	hsa-mir-370	Tuberculosis	3p inhibition in TB progression.
lncRNA target	36210713	hsa-mir-125b	Ovarian Neoplasms	[MiR-125b-5 suppresses ovarian cancer cell migration and invasion by targeted OBJECTIVE: To investigate whether miR-125b-5p regulates biological behaviors of ovarian cancer cells by targeted regulation of CD147 expression.
genetics_knock down_suppress	36210706	hsa-let-7g	Urinary Bladder Neoplasms	Knocking down HMGB2 could partially reverse the effect of let-7g-3p knockdown on the biological behaviors of the bladder cancer cells.
transcription factor target	36210463	hsa-mir-124	Colorectal Neoplasms	5p through YAP1 nuclear translocation.
transcription factor target	36210463	hsa-mir-188	Colorectal Neoplasms	5p through YAP1 nuclear translocation.
transcription factor target	36210420	hsa-mir-210	Melanoma	The results of our study showed that miR-210/ISCU/ROS axis can serve as a novel therapeutic target in melanoma.
transcription factor target	36209087	hsa-mir-133a	Polycystic Ovary Syndrome	CONCLUSION: MiR-133a-3p promotes ovary IR on GCs of obese PCOS patients via inhibiting PI3K/AKT signaling pathway.
transcription factor target	36209049	hsa-mir-92a-2	Diabetic Cardiomyopathies	CONCLUSIONS: miR-92a5p plays an important role in cardiac oxidative stress, and may serve as a therapeutic target in DCM.
genetics_overexpression_promote	36209036	hsa-mir-539	Wilms Tumor	Overexpression of HOXB2 partially restored the inhibitory effects of miR
other	36208811	hsa-mir-4638	Breast Neoplasms	Overall, this study highlights the possibility of utilizing miR3p as a therapeutic molecule to curb skeletal metastasis of breast cancer cells.
other	36208715	hsa-mir-140	Osteoarthritis	Finally, upregulation of miR-140 in 2D chondrocytes resulted in significant upregulation of WWP2 and WDR1.
lncRNA target	36208372	hsa-mir-433	Colorectal Neoplasms	After analysis, it was found that circ_0001535 acted as a competing endogenous RNA (ceRNA) to inhibit miR
circulation_biomarker_prognosis_up	36208254	hsa-let-7b	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
circulation_biomarker_prognosis_ns	36208254	hsa-mir-146a	Multiple Myeloma	OBJECTIVE: To investigate the expression level and prognostic value of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes in patients with multiple myeloma (MM).
circulation_biomarker_prognosis_up	36208254	hsa-mir-21	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
circulation_biomarker_prognosis_up	36208254	hsa-mir-18a	Multiple Myeloma	CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate.
genetics_knock down_promote	36208253	hsa-mir-21	Multiple Myeloma	KLF5 plasmid with 3'UTR knockout was synthesized and cotransfected into RPMI-8226 cells with hsa-miR-21 mimics, and the proliferation of MM cells was detected by CCK-8 and cell cloning assay.
genetics_overexpression_suppress	36208244	hsa-mir-532	Lymphoma, Large B-Cell, Diffuse	CONCLUSION: Overexpression of miR
lncRNA target	36208243	hsa-mir-126	Lymphoma, Large B-Cell, Diffuse	The DLBCL cell line SU-DHL-4 was transfected with miR-126 inhibitor and its negative control (NC inhibitor) or miR-126 mimics and its negative control (NC mimics).
genetics_overexpression_promote	36208229	hsa-mir-196b	Leukemia, Myeloid, Acute	CONCLUSION: Overexpression of lncRNA XIST can inhibit the proliferation of acute myeloid leukemia cells KG1a and promote apoptosis by down-regulating the expression of miR-196b.
circulation_biomarker_diagnosis_ns	36207607	hsa-mir-20b	 Lymph  Node Metastasis	CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients.
circulation_biomarker_diagnosis_ns	36207607	hsa-mir-20b	Squamous Cell Carcinoma of Head and Neck	CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients.
lncRNA target	36207305	hsa-mir-499a	Bipolar Disorder	Our results suggest that MIR499A dysregulation might contribute to BD development.
lncRNA target	36206975	hsa-mir-150	Bone Diseases	5p inhibition and hydroxyapatite/tricalcium phosphate ceramic powders enhanced bone regeneration.
exosome	36206599	hsa-mir-145	Reperfusion Injury, Cerebral Ischemia	CONCLUSION: Collectively, exosomal miRderived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1.
circulation_biomarker_diagnosis_up	36206272	hsa-mir-19b	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-21	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-222	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-103a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-376a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-26a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_diagnosis_up	36206272	hsa-mir-23a	Polycystic Ovary Syndrome	According to our data, circulating miR
circulation_biomarker_prognosis_ns	36206229	hsa-mir-125b	Inflammatory Bowel Diseases	CONCLUSION: Serum LncRNA THRIL and MiR-125b could be used as potential biomarkers for diagnosis and prognosis of ulcerative colitis and Crohn&#x27;s disease.
genetics_knock down_suppress	36206143	hsa-mir-377	Chordoma	3p overexpression-mediated antitumor effects in chordoma cells were largely attenuated by SMAD3 overexpression.
genetics_overexpression_promote	36206112	hsa-mir-497	Esophageal Squamous Cell Carcinoma	5p overexpression-mediated influences in ESCC cells were largely reversed by the addition of SLC1A5 expressing plasmid.
exosome	36206102	hsa-mir-449a	Stomach Neoplasms	Exosomal circ_0063526 facilitated CDDP resistance in gastric cancer via regulating the miR-449a/SHMT2 axis.
other	36206098	hsa-mir-197	Pituitary Neoplasms	Our findings suggest a regulatory network of lncRNA MYMLR/miR3p/CBR1, which benefits the understanding of PA development and provides a promising lncRNA-direct therapeutic strategy against PA.
genetics_overexpression_suppress	36206095	hsa-mir-512	Carcinoma, Non-Small-Cell Lung	5p could be sponged by circ_0010235, and its overexpression had an inhibition effect on the PTX resistance of NSCLC cells.
genetics_knock down_suppress	36204881	hsa-mir-197	Gastrointestinal Stromal Tumors	3p reversed the effect of circ-CCS knockdown on apoptosis and autophagy in GIST cells.
other	36204642	hsa-mir-23b	Carcinoma, Hepatocellular	Based on their RNA-RNA interaction and expression analysis, four DElncRNAs (TRHDE-AS1, DLX6-AS1, SNHG14, HOXA11-AS), four DEmiRNAs (miR-23b, miR-320a, miR-589, miR-126) and five DEmRNAs (PKIA, PCDHA2, SHCBP1, PRSS16, KIF18A) in HCC tumor vs normal groups were subjected to the hub regulatory networks analysis and further prognostic value analysis. Importantly, the TRHDE-AS1/miR-23b/PKIA ceRNA network was associated with HCC prognosis.
other	36204577	hsa-mir-222	Cardiomyopathies	CONCLUSION: In summary, we propose that THBS1 may be a key IRHG, and can serve as a biomarker for the diagnosis of SCM; in addition, the immune-related regulatory network miR3p/THBS1 may be involved in the regulation of the pathogenesis of SCM and may serve as a promising candidate for SCM therapy.
other	36204312	hsa-mir-21	Tuberculosis	A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation.
other	36204312	hsa-mir-600	Tuberculosis	A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation.
target gene	36204179	hsa-mir-522	Stomach Neoplasms	MiR-522-3p Targets Transcription Factor 4 to Overcome Cisplatin Resistance of Gastric Cells.
lncRNA target	36204112	hsa-mir-129-1	Neurotoxicity Syndromes	Collectively, we found a novel circ_0015891/miR1-3p axis that may be a promising therapeutic target for METH-induced dopaminergic neurotoxicity.
other	36203804	hsa-mir-145	Dementia, Vascular	5p), six TFs (Csrnp1, Klf4, Nfatc4, Rxrg, Foxj2, and Klf5), and five mRNAs (Serpine1, Plec, Nedd4l, Trip12, and Tpm1) were significantly changed in rats with VaD, in line with the outcome of RNA sequencing.
circRNA target	36203795	hsa-mir-7001	Postoperative Cognitive Complications	5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD.
circRNA target	36203795	hsa-mir-490	Postoperative Cognitive Complications	5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD.
lncRNA target	36203618	hsa-mir-150	Osteoarthritis	5p were lower in human OA synovial tissue compared with non-OA specimens.
other	36203524	hsa-mir-421	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-339	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-18a	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-483	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-133a	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-584	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-122	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
other	36203524	hsa-mir-106b	Nasopharyngeal Carcinoma	5p are differentially regulated after chemoradiotherapy in NPC.
genetics_knock down_suppress	36203485	hsa-mir-34c	Stomach Neoplasms	This study aimed to investigate the expression, biological function, and downstream mechanism of miR-34c-5p in GC, provide new targets for gastric cancer diagnosis and treatment. miR-34c-5p overexpression inhibited migration, invasion, and colony formation of gastric cancer cells, the related protein E-cadherin expression was significantly increased and N-cadherin, vimentin, and PCNA expression were significantly decreased, while miR-34c-5p knockdown exerted the opposite effects.
lncRNA target	36203462	hsa-mir-182	Carcinoma, Hepatocellular	Notably, while the expression of most miRs deregulated in preneoplastic lesions was not altered in HCC or in hepatoma cells, miR-182, a miR known to target Dio1 and mitochondrial complexes, was down-deregulated by T3 treatment at all stages of hepatocarcinogenesis and in hepatocarcinoma cell lines. In support to the possible critical role of miR-182 in hepatocarcinogenesis, exogenous expression of this miR significantly impaired the inhibitory effect of T3 on the clonogenic growth capacity of human HCC cells.
exosome	36203260	hsa-mir-375	Hepatitis C	miR-375, secreted through exosomes derived from HCV-infected cells, could also be transferred to naive Huh7.5 cells, resulting in an increase in cell proliferation and migration in the recipient cells.
lncRNA target	36202872	hsa-mir-186	Triple Negative Breast Neoplasms	5p regulated the cell viability rate of docetaxel-resistant breast cancer cells.
lncRNA target	36202651	hsa-mir-335	Adrenal Cortex Neoplasms	CONCLUSION: A messenger RNA-microRNA-long noncoding RNA network analysis identified the BIRC5-miR335-5p-PAX8-AS1 network as one that was associated with poor overall survival in adrenocortical carcinoma, warranting further validation as a potential therapeutic target.
other	36202613	hsa-mir-16	Distal myopathy, Nonaka type	To the best of our knowledge, this is the first time that a predictive signature has been composed of genes belonging to the same mechanism (miR-16) in UM. Altogether, our results strongly suggest that UM is a miR-16 disease.
other	36202232	hsa-mir-363	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-1	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-206	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-4286	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-146a	Melanoma	3p (>2.5-fold increase, P < 0.014).
other	36202232	hsa-mir-196b	Melanoma	3p (>2.5-fold increase, P < 0.014).
genetics_knock down_suppress	36202224	hsa-mir-424	von Willebrand Diseases	Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro.
genetics_knock down_suppress	36202224	hsa-mir-424	Breast Neoplasms	Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro.
transcription factor target	36202203	hsa-mir-17	Necrobiotic Disorders	5p inhibitor cell model, resulting in the inactivation of NLRP3 inflammasome-dependent pyroptosis.
circulation_biomarker_diagnosis_up	36201274	hsa-mir-26b	Cardiomegaly	Thereafter, the CHF rats were injected with relative oligonucleotides and plasmids of HDAC3, miR-26b-3p and HMGA2 to detect the cardiac function, inflammatory reaction, myocardial tissue pathological changes, and cardiomyocyte apoptosis.
transcription factor target	36200697	hsa-mir-527	Acute Kidney Injury	CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1.
transcription factor target	36200697	hsa-mir-527	Sepsis	CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1.
genetics_knock down_promote	36200682	hsa-mir-421	Pancreatic Carcinoma	HIF-1alpha overexpression reversed the inhibiting effects of SIRT3 overexpression on PC progression and counteracted the inhibiting effects of miR-421 knockdown on glycolysis.
other	36200549	hsa-mir-223	Diabetes Mellitus	After inclusion of covariates, age, gender (male), New York Heart Association class and diabetes into the multivariate Cox regression model, miR-223 did not reach statistical significance (HR: 2.56, 95% CI: 0.79-8.33; p = 0.118).
genetics_knock down_suppress	36200529	hsa-mir-20b	Colorectal Neoplasms	Reducing miR-20b-3p or raising DEPDC1 levels weakened the effect of SIRT1 knockdown on L-OHP-resistant-CRC cells.
other	36200149	hsa-mir-3074	Diabetic Ischemia Complication	One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p.
other	36200149	hsa-mir-3074	Diabetes Mellitus	One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p.
genetics_overexpression_promote	36200131	hsa-mir-194	Hypertensive Retinopathy	5p upregulation restrained angiogenesis and increased tight junction protein levels in Ang II-treated HRMECs, and the effect was reversed by SOX17 overexpression.
other	36200027	hsa-mir-139	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-148	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-1305	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
other	36200027	hsa-mir-376	Adrenocortical Carcinoma, Pediatric	We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors.
circulation_biomarker_diagnosis_ns	36200021	hsa-mir-29	Hypertension	OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia.
genetics_GWAS	36200021	hsa-mir-21	Hypertension	METHOD: In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P = 0.005 and P = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P = 0.002 and P = 0.048).
circulation_biomarker_diagnosis_ns	36200021	hsa-mir-199	Hypertension	OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia.
lncRNA target	36199788	hsa-mir-31	Osteosarcoma	3p affected the occurrence and development of osteosarcoma by targeting the SOCS1/JAK2/STAT3 signaling pathway.
exosome	36199785	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	Macrophages transfected with miR-1246 inhibitor suppressed LSCC cell viability, migration, and invasion. CONCLUSION: In summary, our data implied that the exosomal, miR-1246 of LSCC, induced polarization of M2 type macrophages and promoted the progression of LSCC.
lncRNA target	36199571	hsa-mir-154	Urinary Bladder Neoplasms	Second, significantly altered miRNAs in recurrent bladder cancer were identified, with miR5p showing the highest level of editing in recurrent bladder cancer and may up-regulate the expression levels of downstream targets HS3ST3A1, AQP9, MYLK, and RAB23.
target gene	36199554	hsa-mir-7	Colorectal Neoplasms	The Transcription Factor Otc4A Stimulates the Proliferation, Invasion, and Stemness of Colorectal Cancer Cells by Inhibiting the Regulation of miR-7-5p on TLR4.
other	36199284	hsa-mir-21	Esophageal Neoplasms	However, the results are varied, and no studies on the diagnostic usefulness of miR-21 in Asian esophageal cancer (EC) patients have been published. CONCLUSION: Our findings suggest miR-21 might be the potential biomarker for detecting EC in Asian populations, with a good diagnostic value.
lncRNA target	36199080	hsa-mir-10a	Osteosarcoma	CONCLUSION: Lnc-SELPLG-2:1 is an oncogenesis activator in osteosarcoma, and its functions are performed via hsa-miR-10a-5p /BTRC cascade.
genetics_knock down_promote	36198257	hsa-mir-133b	Pneumonia, Mycoplasma	CONCLUSION: The current evidence demonstrated that circ_0088196 knockdown facilitated trophoblastic cell development by regulating the levels of miR-133b and AHNAK, suggesting that circ_0088196 promoted the PE progression via the miR-133b/AHNAK axis.
genetics_overexpression_promote	36198203	hsa-mir-20b	Uterine Cervical Neoplasms	The impacts of MEF2C-AS1 elevation on CC cell proliferative, migratory, and angiogenic capabilities were countervailed by miR-20 b-5p overexpression.
circulation_biomarker_diagnosis_ns	36198129	hsa-mir-499	Myocardial Infarction	It enables the rapid detection of an AMI-related miRNA (miR-499) at 10 aM in human serum within 30 min using the SNAzyme-catalyzed luminol-H(2)O(2) ECL reaction. This sensing strategy is then utilized for AMI diagnosis via probing endogenous miR-499 in patients' circulating blood with endogenous miR-16 as an intrinsic reference, showing a significant difference (P < 0.001) between the miR-499 levels of patients and the healthy.
lncRNA target	36197604	hsa-mir-21	Coronary Artery Disease	CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation.
lncRNA target	36197604	hsa-mir-133b	Coronary Artery Disease	CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation.
genetics_overexpression_promote	36197580	hsa-mir-377	Glioma	3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation.
circulation_biomarker_prognosis_down	36197268	hsa-mir-34a	Osteosarcoma	CONCLUSION: The expression level of serum miR-34a in patients with OS is closely related to the chemotherapy resistance, metastasis, recurrence, and survival of osteosarcoma, which can be used as one of the potential biomarkers and prognosis for the treatment of OS patients.
circulation_biomarker_diagnosis_ns	36197244	hsa-mir-21	Cardiomegaly	These findings indicate the potential crosstalk between serum miR-21 and inflammation during CHF progression, suggesting the potential of miR-21 in CHF diagnosis, severity indication, and treatment.
genetics_overexpression_suppress	36196919	hsa-mir-760	Carcinoma, Non-Small-Cell Lung	Furthermore, KIF2A overexpression neutralized miR
other	36196089	hsa-mir-22	Myopathies, Structural, Congenital	Our results identify RYR1, ATPB2B and miRNA-22 as common transcripts whose expression is decreased in muscles from congenital myopathy patients.
lncRNA target	36195937	hsa-mir-148a	Cardiomegaly	Similar results were obtained in angiotensin II-induced hypertrophy of NRCMs, in which the beneficial effects of HHP-EXO were abolished by miRNA-148a inhibition.
genetics_overexpression_promote	36195847	hsa-mir-200a	Papillomavirus Infections	RESULTS: The results demonstrated that miR-200a-3p overexpression suppressed proliferation, migration, and invasion of the HPV-negative C33A cells but promoted the growth and metastasis of HPV-positive CC cells, while YAP promoted the cell growth and metastasis not only in HPV-negative but also in the HPV-positive CC cells.
lncRNA target	36195691	hsa-mir-1192	Reperfusion Injury, Cerebral Ischemia	Overall, GAS5 silencing inhibited AQP4 through the miR-1192/STAT5A axis, thus alleviating cerebral I/R injury.
circulation_biomarker_diagnosis_ns	36195304	hsa-mir-492	Pneumonia, Mycoplasma	OBJECTIVE: This study aimed to evaluate the role of miRNA-492 in the progression of mycoplasma pneumoniae (MP) infection in pediatric patients. CONCLUSION: The present study's results suggested that miRNA-492 might play a role in the pathogenesis of mycoplasma pneumoniae pneumonia in children by regulating the secretion of immune-inflammatory factors such as IL-6 and IL-18 in the mononuclear macrophages.
transcription factor target	36195241	hsa-mir-181b	Liver Cirrhosis	Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis.
transcription factor target	36195241	hsa-mir-181b	Schistosomiasis	Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis.
other	36194985	hsa-mir-619	Osteoarthritis	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
other	36194985	hsa-mir-619	Osteoarthritis 	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
other	36194985	hsa-mir-619	Inflammation	CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention.
lncRNA target	36194972	hsa-mir-221	Arthritis, Rheumatoid	The therapeutic effect of triptolide on miR-221 Exs was reversed by miR-221 inhibitor in both normal and RA FLS.
genetics_GWAS	36194668	hsa-mir-181a	Retinal Diseases	Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches.
genetics_GWAS	36194668	hsa-mir-181b	Retinal Diseases	Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches.
genetics_GWAS	36194484	hsa-mir-1307	Anxiety Disorders	OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population.
genetics_GWAS	36194484	hsa-mir-1307	Depression	OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population.
target gene	36193940	hsa-mir-214	Carcinoma, Non-Small-Cell Lung	CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells.
genetics_knock down_promote	36193788	hsa-mir-1253	Lung Neoplasms	Circ-EIF3I could sponge miR-1253, and miR-1253 inhibitor overturned the regulation of circ-EIF3I knockdown on LC cell progression.
genetics_overexpression_promote	36193608	hsa-mir-9a	Ceroid lipofuscinosis, neuronal 5	In the VILI rat model, miR-9a-5p targeted the negative regulation of CXCR4, and CXCR4 overexpression to reverse the lung-protective and anti-inflammatory effects of miR-9a-5p overexpression in VILI rats.
transcription factor target	36193608	hsa-mir-9a	Lung Injury	CONCLUSION: miR-9a-5p can hinder the activation of the MAPK/ERK signaling pathway and reduce inflammatory reactions and lung injury in VILI rats through the targeted regulation of CXCR4 expression.
lncRNA target	36193590	hsa-let-7e	Hematologic Diseases	Let-7e-5p may be a potential therapeutic target of benzene-induced hematotoxicity, provide a basis for evaluating the health hazards of long-term and low-dose benzene exposure in workers, and supply a reference for revising occupational health standards.
lncRNA target	36193508	hsa-mir-182	Carcinoma, Non-Small-Cell Lung	CONCLUSION: We demonstrated that hsa_circ_0003176 suppressed the NSCLC progression via regulating miR
other	36193506	hsa-mir-28	Pain	5p in PA cells.
other	36193503	hsa-mir-125b	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-181a	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-139	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-29b	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-140	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
other	36193503	hsa-mir-122	Hepatitis B, Chronic	5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established.
genetics_GWAS	36193501	hsa-mir-137	Bipolar Disorder	This preliminary study is aimed at investigating the effects of genetic variations in miR-137 (rs1625579A/C), TCF4 (rs1261084C/T), and CACNA1C (rs10774053A/G and rs10466907G/T) on BD susceptibility.
lncRNA target	36193326	hsa-mir-20a	Femur Head Necrosis	Moreover, we proposed a ceRNA network of lncRNAs targeting hsa-miR-320a, hsa-miR-320a, and NOD2 as a potential RNA regulatory pathway that controls disease progression in ONFH.
transcription factor target	36193307	hsa-mir-20a	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
transcription factor target	36193307	hsa-mir-636	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
transcription factor target	36193307	hsa-mir-7	Colorectal Neoplasms	5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC.
other	36193251	hsa-mir-100	Melanoma	5p is revealed, and the present study is followed by a discussion of its molecular regulatory network, followed by novel insights into SKCM therapy.
circulation_biomarker_diagnosis_ns	36193149	hsa-mir-184	Respiratory Distress Syndrome	OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3.
circulation_biomarker_diagnosis_ns	36193149	hsa-mir-126	Respiratory Distress Syndrome	OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3.
genetics_knock down_suppress	36193129	hsa-mir-654	Colonic Neoplasms	CONCLUSION: Collectively, this study revealed that the knockdown of LINC01124 inhibited the malignant behaviors of CC via the miR
other	36193069	hsa-mir-192	Glioma	5p/ZEB2 axis.
genetics_knock down_promote	36192755	hsa-mir-1827	Carcinoma, Non-Small-Cell Lung	Also, SLC1A5 overexpression abolished the inhibition effect of miR-1827 on NSCLC cell progression.
circulation_biomarker_diagnosis_ns	36192429	hsa-mir-126	Carotid Artery Diseases	Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability.
circulation_biomarker_diagnosis_ns	36192429	hsa-mir-223	Carotid Artery Diseases	Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability.
genetics_knock down_promote	36192016	hsa-mir-1303	Carcinoma, Hepatocellular	Knockdown of miR-1303 attenuated cell proliferation, migration and invasion, and induced apoptosis in liver-cancer cells.
lncRNA target	36192016	hsa-mir-1303	Liver Neoplasms	However, the biological role of miR-1303 in the progression of liver cancer and its regulatory mechanism has not been elucidated. CONCLUSION: miR-1303 plays an important role in liver cancer, which is inhibited by TLN1 expression.
other	36191794	hsa-mir-328a	Pregnancy, Prolonged	Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage.
other	36191794	hsa-mir-328a	Sciatic Neuropathy	Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage.
circRNA target	36191606	hsa-mir-765	Fluoride Poisoning	We further showed that hsa_circ_0007478/miR-765/EFNA3 axis could also be involved in the inhibition of the lipid metabolism and foam cells formation in ox-LDL-macrophages.
lncRNA target	36191448	hsa-mir-125b	Ovarian Neoplasms	CONCLUSION: KCNQ1OT1 accelerated OC progression via miR-125b-5p/CD147 axis indicating KCNQ1OT1 serve as a novel biomarker for OC treatment.
lncRNA target	36191447	hsa-mir-648	Stomach Neoplasms	METHODS: The current study sought to evaluate the miR-648 expression in GC and any plausibility of its replacement, either with or without the combination of chemo agents to downregulate ET-1 expression through interaction with its target gene.
circulation_biomarker_diagnosis_ns	36191258	hsa-mir-210	Sleep Apnea, Obstructive	ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance.
circulation_biomarker_diagnosis_ns	36191258	hsa-mir-210	Acute Lung Injury	ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance.
genetics_overexpression_promote	36190650	hsa-mir-206	Esophageal Neoplasms	Meanwhile, overexpression of HOXA13 partially reversed the suppressive effects of miR-206 enrichment on ESCC cell malignant behaviors. CONCLUSION: In short, circ_0008726 exerted the carcinogenic effects to regulate the proliferation, invasion, angiogenesis and apoptosis of ESCC cells by targeting miR-206/HOXA13 axis.
lncRNA target	36190453	hsa-mir-375	Stomach Neoplasms	This study provides a potential target for gastric cancer progression based on the circRPPH1/miR-375/SLC7A11 regulatory axis.
circRNA target	36190397	hsa-mir-1234	Stomach Neoplasms	Furthermore, OE of hsa_circ_0006470 inhibited the tumorigenesis of GC via the regulation of the miR-1234/TP53I11 axis. In summary, the present study demonstrated that OE of hsa_circ_0006470 notably inhibited the tumorigenesis of GC by regulating the miR-1234/TP53I11 axis.
exosome	36190183	hsa-mir-221	Cerebrovascular Disorders	In conclusion, miR3p in EPC derived exosomes ameliorates OGD-induced neuronal apoptosis, which establish its potential as a new therapeutic method for patients with cerebrovascular diseases.
other	36189421	hsa-mir-143	Colorectal Neoplasms	Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells.
lncRNA target	36189147	hsa-mir-133c	Myocardial Reperfusion Injury	CONCLUSION: In sum, the identified ceRNA network which included the lncRNA Xist/miR-133c/Slc30a9 axis might contribute a better understanding to the pathogenesis and development of MI/R injury and offer a novel targeted therapy way.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-181a	Rh-Negative Hemolytic Disease, Fetus	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-125b-2	Rh-Negative Hemolytic Disease, Fetus	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-181a	Placenta Diseases	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
circulation_biomarker_diagnosis_ns	36188428	hsa-mir-125b-2	Placenta Diseases	3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN.
other	36188379	hsa-mir-379	Epilepsies, Partial	"However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence."
other	36188379	hsa-mir-154	Epilepsies, Partial	"However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence."
circulation_biomarker_diagnosis_up	36188229	hsa-mir-19b	Breast Neoplasms	Results: In the screening phase, 5 circulating miRNAs (miR-16, miR-17, miR-19b, miR-27a, and miR-106a) were identified as the most significantly upregulated miRNAs in plasma of BC patients. Conclusion: The current study developed a miR-19b-based 3-miRNA model holding potential for diagnosis of BC using blood samples.
other	36187569	hsa-mir-424	Gram-Negative Bacterial Infections	The duplex test, including miR-424 and CRP, has a diagnostic value for detecting the high risk of post-transplant gram-negative bacteremia in heart and lung transplant recipients.
epigenetics	36187230	hsa-mir-194	Ovarian Neoplasms	CONCLUSION: Our work demonstrates that lncRNA DARS-AS1 promotes OC progression by modulating TSPAN1 and ITGA2 hypomethylation by binding with miR
genetics_knock down_promote	36187163	hsa-mir-155	Pancreatitis	Multivariate analysis showed that the BISAP score, BUN, Leukocytes, age and CRP were independent risk factors for progression to SAP among AP patients after adjusting for hypertension, ICU admission, hospital stay and Fibrinogen, while miR-155 was a protective factor.
other	36187128	hsa-mir-503	Diabetes Mellitus, Type 2	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-503	Carotid Artery Diseases	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-4435-1	Carotid Artery Diseases	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
other	36187128	hsa-mir-4435-1	Diabetes Mellitus, Type 2	We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP.
transcription factor target	36186733	hsa-mir-642a	Inflammation	These results suggest that miR-642a-5p can inhibit the inflammation by suppressing the TLR4 signalling pathway in THP-1 cells.
other	36186733	hsa-mir-642a	Inflammatory Bowel Disease 11	Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response.
circulation_biomarker_diagnosis_down	36186733	hsa-mir-642a	Glucocorticoid Receptor Deficiency	Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response. We found that after treatment with miR-642a-5p mimics and DEX, the expression levels of glucocorticoid receptor (GR) in the nucleus and NF-kappaB p65 and p50 in the cytoplasm were increased (P < 0.05).
circulation_biomarker_prognosis_ns	36186528	hsa-mir-34a	Respiratory Distress Syndrome, Newborn	CONCLUSION: Serum miR-34a, Ang-1, and NCIS are closely related to the severity and prognosis of neonatal RDS.
other	36186470	hsa-mir-378f	Diabetic Retinopathy	3p and -665 can be used as powerful markers for DR diagnosis, and the ceRNA network: lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 may represent an important regulatory role in DR progression.
genetics_knock down_promote	36186461	hsa-mir-466	Non-alcoholic Fatty Liver Disease	These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway.
genetics_knock down_promote	36186461	hsa-mir-669c	Non-alcoholic Fatty Liver Disease	These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway.
epigenetics	36186442	hsa-mir-21	Carcinoma, Renal Cell	High PRKCE methylation levels and hsa-miR5p may contribute to PRKCE low expression in KIRC.
other	36186432	hsa-mir-17	Peripheral Arterial Occlusive Disease 1	Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD.
other	36186432	hsa-mir-20b	Peripheral Arterial Occlusive Disease 1	Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD.
genetics_knock down_promote	36186122	hsa-mir-124	Cognition Disorders	Here we reported age-related loss of miR-124 in human and rat brains. Our work suggested that age-related cognitive decline, at least in part, was associated with miR-124 deficiency and subsequently upregulated RyR3 expression in inducing neuronal death.
exosome	36185995	hsa-mir-10b	Colorectal Neoplasms	Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database.
exosome	36185995	hsa-mir-150	Colorectal Neoplasms	Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database.
other	36185765	hsa-mir-363	Ischemic Stroke	This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1).
other	36185765	hsa-mir-4500	Ischemic Stroke	This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1).
other	36185590	hsa-mir-133a	Myocardial Infarction	Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination.
other	36185590	hsa-mir-1	Myocardial Infarction	Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination.
other	36185502	hsa-mir-384	Thyroid Neoplasms	Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384.
circulation_biomarker_diagnosis_down	36185088	hsa-mir-130a	psoriasis 1	Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis.
circulation_biomarker_prognosis_ns	36185088	hsa-mir-130a	Abnormalities, Multiple	Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis.
lncRNA target	36184817	hsa-mir-140	Memory Disorders	5p inhibition enhanced Pin1 and ADAM10 mRNA expressions but has little effect on Pin1 protein level.
transcription factor target	36184552	hsa-mir-32	Atherosclerosis	5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation.
transcription factor target	36184552	hsa-mir-32	Inflammation	5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation.
lncRNA target	36184551	hsa-mir-6870	Coronary Artery Disease	3p regulates human EAT inflammation by targeting the Tollip-mediated JNK and NF-kappaB signaling pathways.
lncRNA target	36184541	hsa-mir-466	Myocardial Reperfusion Injury	Thus, LincRNA-p21 positively regulated the expression of Nr4a2, through sponging miR-466i-5p, promoting cardiomyocyte apoptosis in myocardial I/R injury. The current study revealed a novel LincRNA-p21/miR-466i-5p/Nr4a2 pathway for myocardial I/R injury, indicating that LincRNA-p21 may serve as a potential target for future therapy.
lncRNA target	36184488	hsa-mir-214	Squamous Cell Carcinoma of Head and Neck	CircFNDC3B silencing restrains the tumorigenesis of oesophageal squamous cell carcinoma through miR3p/CDC25A axis, which opens a new window to the development of novel therapeutic strategy for ESCC patients.
transcription factor target	36184123	hsa-mir-520d	Osteosarcoma	Our results suggests that RPS inhibits the VM formation and metastasis of OS by modulating the miR-520d-3p/MIG-7 signaling axis.
transcription factor target	36183924	hsa-mir-203	Pancreatic Carcinoma	In this study we aimed to explore interaction between downregulated miR-203 and its upregulated target DUSP5 in PC. CONCLUSIONS: These findings suggest that miR-203 restrains proliferation and migration of PC cells by regulating oncogenic activity of DUSP5 in PC, thereby could be novel candidate biomarkers for PC diagnosis and treatment.
transcription factor target	36183365	hsa-mir-20	Adenocarcinoma of Lung	Bioinformatics analyses suggested that SIGLEC17P might exert antioncogenic effects in LUAD through the mir
genetics_knock down_suppress	36183123	hsa-mir-1297	Glioma	More importantly, under TMZ treatment, inhibition of miR-1297 attenuated TMZ treatment on glioma cells; ADM knockdown partially attenuated the effects of miR-1297 inhibition on TMZ-treated glioma cells.
genetics_overexpression_promote	36183046	hsa-mir-193a	Carcinoma, Non-Small-Cell Lung	We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1.
other	36182923	hsa-mir-222	Polycystic Ovary Syndrome	3p assisted PCOS diagnosis and predicted increased risks of diabetic and cardiovascular complications.
transcription factor target	36181964	hsa-mir-365b	Alzheimer Disease	Based on the evidence, we finally identified hsa-miR-365b-5p as a key target in Alzheimer's disease. CONCLUSIONS: Hsa-miR-365b-5p act as a key target in Alzheimer's disease.
circulation_biomarker_diagnosis_up	36181627	hsa-let-7c	Moyamoya Disease	Our results demonstrated that the TLR7 and microRNA Let-7c expression are upregulated in VSMCs and the plasma of MMD patients, respectively.
other	36181617	hsa-mir-34a	Diabetes Mellitus, Type 2	After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity.
other	36181617	hsa-mir-143	Diabetes Mellitus, Type 2	After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity.
genetics_knock down_promote	36181561	hsa-mir-634	Squamous Cell Carcinoma of Head and Neck	MiR-634 targeted MAP2K4 and negatively regulated MAP2K4 expression, and overexpression of miR-634 inhibited TSCC cell proliferation, migration, and invasion, while co-overexpression of MAP2K4 was able to reverse the effects of miR-634 in TSCC cells.
lncRNA target	36181383	hsa-mir-137	Inflammation	CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment.
lncRNA target	36181383	hsa-mir-137	Norrie disease	In addition, miR-137 expression was negatively correlated with circHOMER1 and SOX6 expression in DN patients. CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment.
lncRNA target	36181281	hsa-mir-665	Colorectal Neoplasms	We further demonsatred that miR-665/E2F3 axis mediated the functional role of hsa_circ_0081069 in regulating the malignant phenotype of CRC cells. Targeting hsa_circ_0081069 and miR-665/E2F3 axis could serve as potential therapeutic strategies for CRC treatment.
genetics_overexpression_promote	36180981	hsa-mir-514b	Carcinoma, Non-Small-Cell Lung	Furthermore, overexpression of miR-514b-5p promoted NSCLC cell growth and suppressed apoptosis by inducing the activation of the phosphatidylinositol
other	36180946	hsa-mir-556	Acute Kidney Injury	Urine miR3p had the potential to improve the prediction of renal recovery from severe AKI.
circRNA target	36180890	hsa-mir-409	Breast Neoplasms	CONCLUSION: CircTRIM28 facilitated the BC via miR
lncRNA target	36180862	hsa-mir-107	Acute Lung Injury	This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107.
lncRNA target	36180862	hsa-mir-107	Sepsis	This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107.
other	36180575	hsa-mir-93	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-20a	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-17	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-195	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-19a	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-144	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-142	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180575	hsa-mir-16	Retinal Vein Occlusion	5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group.
other	36180561	hsa-mir-26b	Obesity	Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction.
circulation_biomarker_diagnosis_up	36180561	hsa-mir-155	Obesity	No changes were observed in the group of obese female dogs with normal serum biochemical profile and in relation to miR-155 expression.
other	36180561	hsa-mir-132	Obesity	Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction.
other	36180558	hsa-mir-28	Carcinoma, Renal Cell	The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively.
other	36180558	hsa-mir-125a	Carcinoma, Renal Cell	The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively.
circulation_biomarker_diagnosis_down	36180486	hsa-mir-21	Glioblastoma	We suggest that the increased exosomal miR-21 from Toxoplasma-infected BV2 microglial cells may play an important role as a cell growth promotor of U87 glioma cells through a down-regulation of anti-tumorigenic genes.
other	36180298	hsa-mir-133a-1	Diabetes Mellitus, Type 2	rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM.
other	36180298	hsa-let-7f	Diabetes Mellitus, Type 2	rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM.
transcription factor target	36180007	hsa-mir-27a	Thyroid Cancer, Papillary	Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2.
transcription factor target	36180007	hsa-mir-27a	Ischemic Stroke	Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2.
lncRNA target	36179941	hsa-mir-103a	Graves Ophthalmopathy	miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels.
lncRNA target	36179941	hsa-mir-103a	Diabetic Nephropathies	miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels.
circulation_biomarker_diagnosis_ns	36178486	hsa-mir-92a	Sepsis	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circulation_biomarker_diagnosis_down	36178486	hsa-mir-92a	Polycythemia	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circulation_biomarker_diagnosis_ns	36178486	hsa-mir-92a	beta-Thalassemia	OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells.
circRNA target	36178207	hsa-mir-122	Uterine Cervical Neoplasms	5p competition and thus promotes the development of CC, providing a novel targeted therapy for CC.
lncRNA target	36178080	hsa-mir-144	Osteoarthritis	CONCLUSION: LncRNA TM1-3P improved inflammation and damage of knee joints in OA rats through miR3p/ONECUT2 axis, providing a new theoretical basis for gene therapy of OA.
other	36177926	hsa-mir-494	Cystic Fibrosis	OBJECTIVE: To observe the effects of Xiaoqinglong Decoction and Qingqi Huatan Pills on interleukin-1beta (IL-1beta)-induced mucushypersecretion model of human airway epithelial H292 cellsand related molecules of nuclear factor-kappaB/microRNA-494(NF-kappaB/miR-494) signaling pathway, and to explore the mechanism of the two medicines in improving pathological airway mucus.
transcription factor target	36177783	hsa-mir-204	Brain Injuries	These results suggest that down-regulation of miR5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting VCAM1.
other	36177782	hsa-mir-16	Premature Ejaculation	We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls.
other	36177588	hsa-mir-203a	Vascular Diseases	5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01).
other	36177588	hsa-mir-29	Vascular Diseases	5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01).
circulation_biomarker_diagnosis_up	36177494	hsa-mir-125b	Lupus Erythematosus, Systemic	5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls.
circulation_biomarker_diagnosis_up	36177494	hsa-mir-9	Lupus Erythematosus, Systemic	5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls.
transcription factor target	36177008	hsa-mir-27b	Inflammatory Bowel Diseases	Moreover, the marked upregulation of six miR-27b target genes (IFI16, GCA, CYP1B1, RUNX1, MEF2C and MMP13) in the inflamed colon tissues is a possible direct consequence of the lack of repression due to the downregulated miRNA-27b expression.
lncRNA target	36176750	hsa-mir-186	Mesothelioma, Malignant	Conclusion: We unraveled a novel mechanism of action of butein, which attenuated the pro-tumorigenic features of MPM at least through a miR
other	36176029	hsa-mir-200b	Colitis	Notably, MVs from normal feces could effectively reverse the composition of the intestinal microbiota, restore the intestinal barrier and rescue colitis, and BMVs from colitis would also have similar effects after miR-200b-3p treatment.
genetics_overexpression_promote	36175984	hsa-mir-146a	Spinal Cord Injuries	miR-146a-5p was overexpressed in exosomes, and then, miR-146a-5p-modified exosomes were used to investigate the ability of exosomes to reduce neurotoxic astrocyte effects, preserve neurons and promote neurological function recovery in rats with SCI.
lncRNA target	36175893	hsa-mir-4741	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
lncRNA target	36175893	hsa-mir-508	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
lncRNA target	36175893	hsa-mir-3158	Intervertebral Disc Degeneration	5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets.
other	36175844	hsa-mir-181a	Chronic Disease	CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific.
circulation_biomarker_diagnosis_up	36175844	hsa-mir-181a	Aicardi-Goutieres syndrome 5	This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97. CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific.
circulation_biomarker_diagnosis_up	36175844	hsa-mir-181a	Multiple Chronic Conditions	This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97.
lncRNA target	36175700	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	The results confirmed the anti-tumor impact of berberine on CLL cells through reducing CD69, Ki67, and miR-155 expression and increasing cleaved PARP1 may be considered as an option for future clinical studies.
lncRNA target	36175341	hsa-mir-339	Pain, Postoperative	So, the authors hypothesized that miR5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP.
transcription factor target	36174767	hsa-mir-130a	Osteoporosis	In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRalpha/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats.
other	36174738	hsa-mir-200b	Encephalomyelitis, Eastern Equine	Furthermore, the expression of miR-200b-3p was increased, while that of ERG and PTHrP was markedly reduced in PEE fetal cartilage.
other	36174709	hsa-mir-148a	Osteoporosis	Moreover, histone acetylation of the WNT-1 gene and miR-148a-3p interference proved to play a role in the regulation of the WNT-signalling pathway during OP progression and treatment.
lncRNA target	36174668	hsa-mir-29a	Parkinson Disease	In conclusion, this research provides novel insight into a neuroprotective pathway of miR-29a and could thus serve as a possible therapeutic target for improving the treatment of PD.
lncRNA target	36173586	hsa-mir-101	Abortion, Habitual	3p/OTUD3 may be potential targets for the prevention of unexplained RSA.
other	36173547	hsa-mir-125a	Cataract, Age-Related Nuclear	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR.
other	36173547	hsa-mir-125a	AIDS-Related Complex	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. RESULTS: miR-125a-3p was upregulated in ARC tissues and LECs treated with UVB.
lncRNA target	36173547	hsa-mir-125a	Cataract	METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. CONCLUSION: This study indicated that miR-125a-3p regulated apoptosis by suppressing TMBIM4 in LECs under oxidative damage, providing a new idea for clinical therapeutic target of cataract.
other	36173063	hsa-let-7b	Melanoma	CONCLUSION: In conclusion, we elucidated the regulatory role of the SNHG16-hsa-let-7b-5p-TUBB4A axis in the progression of skin cutaneous melanoma by modulating mitochondrial function to affect cellular metabolism.
genetics_overexpression_promote	36173030	hsa-mir-22	Colorectal Neoplasms	3p in CRC reduced YAP1 expression, whereas overexpression of KDM3A restored the expression of YAP1.
other	36173004	hsa-mir-210	Uterine Cervical Neoplasms	3p and modulates the progression of cervical cancer, which predict the prognosis of cervical cancer patients.
lncRNA target	36172919	hsa-mir-1	Carcinoma, Non-Small-Cell Lung	The QKI-5 expression was anticorrelated with the miR-31 expression in NSCLC patient samples. CONCLUSION: Our results suggest that the miR-31/QKI-5/p21-CDK4-CDK6 axis might have critical functions in the progression of NSCLC, and targeting this axis could serve as a potential therapeutic strategy for NSCLC.
other	36172827	hsa-mir-485	Colorectal Neoplasms	CONCLUSION: Circ_0001535 promotes colorectal cancer cell development by absorbing miR5p and upregulating LASP1.
other	36172678	hsa-mir-409	Lung Neoplasms	CONCLUSION: miR3p may prevent non-small cell lung cancer (NSCLC) by affecting ELF2 transcription and other cellular regulators to regulate A549 cell division and induce apoptosis.
other	36172578	hsa-mir-370	Myocardial Reperfusion Injury	This study revealed that the lncRNA-HRAT/miR3p/RNF41 pathway regulates cardiomyocyte apoptosis and myocardial injury.
other	36172547	hsa-mir-192	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-223	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-26b	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-16-2	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-185	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-485	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-197	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-16	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
other	36172547	hsa-mir-23a	Wounds and Injuries	5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma.
genetics_GWAS	36172375	hsa-mir-146a	Autoimmune Diseases	Our work highlights the pathogenetic role of miR-146a and the potential of pharmacologic inhibition of TRAF6 in autoimmune diseases in which miR-146a is deregulated.
lncRNA target	36172098	hsa-mir-668	Alzheimer Disease	3p may be a potential therapeutic target for AD.
other	36172090	hsa-mir-149	Breast Neoplasms	Rutaecarpine prevents the malignant biological properties of breast cancer cells by the miR-149-3p/S100A4 axis.
other	36171887	hsa-mir-203a	Breast Neoplasms	An mRNA-miRNA network was built to identify an miR-203a-3p/LDHD/LYRM7 regulatory axis in BC.
other	36171576	hsa-mir-126	Adenocarcinoma of Lung	Transduction of miR3p is a potential therapeutic strategy for treating LUAD, yet the physiological environment and properties of miRNA challenge current transduction approaches.
other	36171191	hsa-mir-132	Neurotic Disorders	5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine.
other	36171191	hsa-mir-132	Rubella Syndrome, Congenital	5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine.
circRNA target	36171087	hsa-mir-647	Vascular Diseases	Circular RNA hsa_circ_0000345 (circ_0000345) and miR-647 are related to oxygenized low-density lipoprotein (ox-LDL)-induced arterial smooth muscle cell (ASMC) dysregulation.
genetics_overexpression_promote	36171087	hsa-mir-647	Angelman Syndrome	Mechanistically, circ_0000345 was verified as a miR-647 sponge, and miR-647 overexpression impaired the inhibitory effects of circ_0000345 upregulation on ox-LDL-induced ASMC proliferation, migration, invasion, and inflammatory response.
lncRNA target	36170021	hsa-mir-136	Carcinoma, Renal Cell	CONCLUSIONS: Our findings suggested that lncRNA NLGN1-AS1 could promote the progression of ccRCC by targeting miR5p/FZD4 and Wnt/beta-catenin pathway, and might serve as a novel potential therapeutic target to inhibit the progression of ccRCC.
genetics_knock down_suppress	36169673	hsa-mir-466f	Osteoporosis	* Knockdown of lncRNA NEAT1 inhibited osteoblast cells autophagy by sponging miRNA-466f-3p and targeting HK2 in osteoporosis.
other	36169175	hsa-mir-675	Adrenocortical Carcinoma	The downregulated expression of H19 in ACC compared to ACA correlated with miR675 expression hosted by H19.
genetics_knock down_promote	36169092	hsa-mir-506	Carcinoma, Hepatocellular	In HSC-CM cultured HCC cells, the effects of MIR4435-2HG knockdown on TGFB1 expression and HCC cell phenotypes were partially reversed by miR
other	36168936	hsa-mir-29a	Uterine Cervical Neoplasms	In conclusion, circ_0072995 promoted cervical cancer development by inducing miR-29a-mediated WDR5 expression.Impact statementWhat is already known on this subject? Global Cancer Statistics 2020 estimated that there were 1 021,494 new cases of cervical cancer and 439 201 deaths from cervical cancer. We first reported the promoting effects of circ_0072995 in cervical cancer development by inducing miR-29a mediated WDR5 expression and also revealed the therapeutic potential of circ_0072995, miR-29a, and WDR5 in cervical cancer.
lncRNA target	36168877	hsa-mir-18a	Ischemic Stroke	Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis.
lncRNA target	36168858	hsa-mir-144	Osteoporosis, Diabetic	In conclusion, this study indicated that HG regulated the migration, proliferation, and mineralization of osteoblasts via the miRNA
other	36168845	hsa-mir-619	Biliary Tract Neoplasms	3p represents a potentially valuable diagnostic strategy for identifying BTCs as well as a predictive indicator of BTC prognosis.
other	36168417	hsa-mir-122	Diabetes Mellitus, Type 2	The relationship of miR-126 and miR-122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR-126 expression was related to lower T2DM risk, FBG level and HOMA-IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index.
other	36167817	hsa-mir-26a	Respiratory Sounds	"RESULTS: Two infant factors (daycare attendance, family history of asthma) and three salivary ""omic"" features (miR-26a-5p, Elusimicrobia, Streptococcus phage phiARI0131-1) differed between the two groups (adjusted p < 0.05)."
circulation_biomarker_diagnosis_up	36167754	hsa-mir-182	high grade glioma	The proposed method was highly selective and possessed remarkable capability for evaluating the expression levels of miRNA-182 in serum samples from healthy donors and glioma patients.
lncRNA target	36167718	hsa-mir-451	Osteoarthritis	Moreover, when osteoarthritis (OA) was induced in Sprague Dawley rats via bilateral anterior cruciate ligament transection (ACLT), miR-451 expression was increased in OA cartilage compared to control, suggesting its inhibition might be used to prevent or treat OA. To examine the prophylactic and therapeutic potential of inhibiting miR-451, we evaluated treatment with miR-451 power inhibitor (451-PI) at the onset of joint trauma and treatment after OA had developed.
other	36167680	hsa-mir-890	Hemangioma, Cavernous	Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance.
other	36167680	hsa-mir-890	Hemangioma	Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance.
circulation_biomarker_diagnosis_up	36166353	hsa-mir-199a	Diabetic Neuropathies	Regarding the association between endoplasmic reticulum (ER) stress with the pathogenesis of neuropathy, this study aims to examine binding immunoglobulin protein (BiP) gene expression and long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1), miR-199a-5 as its regulator in the peripheral blood of DN patients compared to diabetic patients without neuropathy.
other	36165177	hsa-mir-96	Crohn Disease	5p had a better performance in recognizing active Crohn's disease with AUROC of 0.727 (95%CI 0.609-0.844, p = .001) than C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fecal calprotectin.
epigenetics	36165173	hsa-mir-1246	Lupus Erythematosus, Systemic	We found that increased histone H3 trimethylation at Lys(27) (H3K27me3) and decreased histone H3 acetylation at Lys(9) and Lys(14) (H3K9/K14ac) in the miR-1246 promoter region are essential for the low expression of miR-1246 in SLE B cells.
other	36164970	hsa-mir-125a	Lupus Erythematosus, Systemic	In conclusion, hsa_circ_0012919 regulated the pyroptosis in the CD4+ T cells of SLE patients by miR-125a-3p/GSDMD axis.
circulation_biomarker_diagnosis_ns	36164928	hsa-mir-296	Diabetes, Gestational	3p in peripheral blood samples from patients with GDM were measured using reverse transcription-quantitative polymerase chain reaction.
other	36164909	hsa-mir-20	Myocardial Reperfusion Injury	Compared with the sham group, the modeling of IR increased the myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and down-regulated the expression of miR-20 b-5 p(P&lt;0.05). The IR+RES+miR-20 b-5 p antagomir group had higher myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and lower expression of miR-20 b-5 p than the IR+RES group(P&lt;0.05).
genetics_knock down_promote	36164726	hsa-mir-656	Carcinoma, Non-Small-Cell Lung	3p downregulation or xCT overexpression partly overturned hsa_circ_0018189 knockdown or miR
lncRNA target	36164699	hsa-mir-338	Osteosarcoma	3p, which could be a new target for OS treatments.
other	36164683	hsa-mir-106b	Arthritis, Rheumatoid	The qRT-PCR results indicated that the expression of lncRNA HOTAIR was markedly decreased and that of miR-106b-5p was markedly increased in HFLSs of RA.
other	36164637	hsa-mir-223	Sepsis	CONCLUSION: Our study shows that all tested miRNAs can be used for early detection of sepsis, with miRNA-223 being predictive of mortality, hence preventing multi-organ failure and reducing mortality, and predicting poor outcomes, thereby assisting in early categorization of ICU patients for rapid appropriate treatment and medico legal aspects.
circRNA target	36164444	hsa-mir-146b	Colorectal Neoplasms	Rescue assays demonstrated circZC3HAV1 sponged miR-146b-3p and upregulated TBC1D9 to restrict migration and invasion of CRC cells. CONCLUSION: circZC3HAV1 could upregulate TBC1D9 via absorbing miR-146b-3p, consequently inhibiting migratory and invasive capabilities of CRC cells.
other	36164345	hsa-mir-187	Stomach Neoplasms	miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway.
genetics_overexpression_promote	36164322	hsa-mir-452	Carcinoma, Hepatocellular	The effects of HCC cell-derived exosomes on accelerating HCC migration and invasion and inducing M2 macrophage polarization were confirmed, which were further enhanced after overexpressing miR
transcription factor target	36163623	hsa-mir-153	Sepsis	Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage.
transcription factor target	36163623	hsa-mir-153	Lung Injury	Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage.
lncRNA target	36163622	hsa-mir-1	Sepsis	Objective To investigate whether long non-coding RNA-HOX transcript antisense intergenic RNA (lncRNA-HOTAIR) regulates the inflammatory response of sepsis by targeting microRNA miR3p.
lncRNA target	36162992	hsa-mir-575	Esophageal Squamous Cell Carcinoma	Mechanistically, RPL34-AS1 acted as a competing endogenous RNA (ceRNA) of miR-575 to relieve the repressive effect of miR-575 on its target ACAA2, then suppressed the tumorigenesis of ESCC.
transcription factor target	36162691	hsa-mir-146a	Depression	We also observed 74 miRNAs associated with depression that are targeted by curcumin, with hsa-miR-146a-5p having the greatest expression and interaction.
other	36162484	hsa-mir-205	Breast Neoplasms	MiR-205 and HELLS could be considered a novel diagnosis and therapeutic molecular marker of breast cancer.
other	36162459	hsa-mir-200a	Diabetes Mellitus	Furthermore, circSCMH1 was observed to induce HG cell growth and EMT by regulating the miR-200a-3p/ZEB1 axis.
genetics_overexpression_promote	36162436	hsa-mir-382	Squamous Cell Carcinoma of Head and Neck	In addition, overexpression of miR
lncRNA target	36162418	hsa-mir-144	Polycystic Ovary Syndrome	The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients.
lncRNA target	36162418	hsa-mir-224	Polycystic Ovary Syndrome	The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients.
other	36162367	hsa-mir-423	Pulmonary Disease, Chronic Obstructive	5p is a potential marker for identifying COPD patients.
other	36161443	hsa-mir-206	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-375	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-19b	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-424	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-221	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
other	36161443	hsa-mir-28	Heart Failure	5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61.
genetics_knock down_promote	36161346	hsa-mir-508	Breast Neoplasms	CONCLUSION: Knockdown of hsa_circ_0002082 suppresses breast cancer growth and metastasis by miR3p/CENPF axis, suggesting that hsa_circ_0002082 may be a promising target for breast cancer treatment.
epigenetics	36161330	hsa-mir-193	Pituitary Neoplasms	In pituitary carcinomas, methylation of autosomal genes PARP15, LINC00599, MIR193 and ZAP70 was higher than in PAs/PITNETs, while X-linked genes methylation level was lower.
lncRNA target	36161300	hsa-mir-144	Uterine Cervical Neoplasms	CONCLUSION: Silencing circPUM1 may inhibit the proliferation, colony formation, migration, invasion and induce apoptosis of cervical cancer cells through targeting and regulating the expression of miR
transcription factor target	36161100	hsa-mir-4739	Osteoporosis	CONCLUSIONS: Overall, we proved that the higher expression of miR-4739 participated in the progression of osteoporosis by targeting ITGA10 and modulating PI3K/AKT signaling pathway, and perhaps miR-4739/ITGA10 axis could be potential diagnostic markers and therapeutic target for osteoporosis.
lncRNA target	36161098	hsa-mir-223	Myocardial Infarction	3p is a potential target for the treatment of myocardial infarction (MI).
genetics_knock down_suppress	36160904	hsa-mir-122	Osteochondritis Dissecans	5p and the knockdown of NDRG3 reversed the inhibitory effects of Meg3 overexpression on the proliferation, migration and angiogenesis of hCMEC/D3 cells subjected to OGD, as well as the promoting effects of Meg3 overexpression on cell apoptosis.
genetics_knock down_suppress	36160896	hsa-mir-3160	Lymphoma, Large B-Cell, Diffuse	Overall, the present study revealed that CACNA1G-AS1-knockdown and miR
transcription factor target	36160881	hsa-mir-146a	Inflammatory Bowel Diseases	At present, the biogenesis, function and role of miR-146a-5p in intestinal epithelial cells (IECs) during the pathogenesis of IBD remain elusive. Therefore, miR-146a-5p may act as an important diagnostic biomarker and treatment target of IBD.
lncRNA target	36160704	hsa-mir-372	Diabetic Cardiomyopathies	3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress.
lncRNA target	36160704	hsa-mir-372	Brain Ischemia	3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress.
other	36160329	hsa-mir-124	Spinal Cord Injuries	METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. CONCLUSIONS: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.
lncRNA target	36160034	hsa-mir-182	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
lncRNA target	36160034	hsa-mir-4506	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
lncRNA target	36160034	hsa-mir-7109	Colorectal Neoplasms	Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC.
other	36160032	hsa-mir-4462	Breast Neoplasms	In this study, after performing GSEA and microarray analysis on the GSE71053 dataset, a new ceRNA network of CCDC18-AS1, LINC01343, hsa-miR4462, and SFN in BC was detected by bioinformatics analysis.
other	36160019	hsa-mir-133	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36160019	hsa-mir-195	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36160019	hsa-mir-181	childhood acute myeloid leukemia	hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated
other	36159813	hsa-mir-29c	Head and Neck Neoplasms	Moreover, the LINC01270/hsa-miR-29c-3p/SFXN3 axis was identified as the most likely upstream non-coding RNA-related pathway of SFXN3 in HNSC using bioinformatic analysis, expression analysis, correlation analysis, and survival analysis.
lncRNA target	36159784	hsa-mir-3061	Intestinal Diseases	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159784	hsa-mir-3061	Sepsis	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159784	hsa-mir-3061	Diabetes Mellitus	CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization.
lncRNA target	36159592	hsa-mir-106b	Muscular Dystrophy, Duchenne	This study demonstrates that miR-106b is an important modulator of SC quiescence, and that miR-106b may be a new target to develop therapeutic strategies to promote muscle regeneration improving the regenerative capabilities of injured dystrophic muscle.
circRNA target	36159584	hsa-mir-140	Osteoarthritis	CONCLUSION: The upregulation of circKMT2E is involved in the chondrocyte apoptosis of the pathogenesis of OA through activation of TLR4 by the sponge function of miR
target gene	36159567	hsa-mir-135a	Liver Neoplasms	HBV Promotes the Proliferation of Liver Cancer Cells through the hsa_circ_0000847/miR-135a Pathway.
transcription factor target	36159559	hsa-mir-132	Cognition Disorders	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD.
transcription factor target	36159559	hsa-mir-132	REM Sleep Behavior Disorder	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD.
transcription factor target	36159559	hsa-mir-13	REM Sleep Behavior Disorder	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model.
transcription factor target	36159559	hsa-mir-13	Cognition Disorders	Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model.
genetics_overexpression_suppress	36158838	hsa-mir-194	Angelman Syndrome	Overall, the current study demonstrated that LINC00452 overexpression reversed oxLDL-induced growth inhibition of HUVECs via regulating the miR5p/IGF1R axis, thus providing a potential beneficial targets for AS.
exosome	36158698	hsa-mir-1246	Squamous Cell Carcinoma of Head and Neck	Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells.
circulation_biomarker_diagnosis_down	36158656	hsa-mir-625	Neuroendocrine Tumors	CONCLUSIONS: Our study suggests that expression of plasma miRNAs miR
genetics_overexpression_promote	36158629	hsa-mir-26a	Carcinoma, Hepatocellular	miR-26a overexpression broadly inhibited the inflammatory response in both hepatocytes and macrophages by decreasing several key oncogenic signaling pathways in HCC promotion.
lncRNA target	36157880	hsa-mir-106a	Glioma	Further research showed that DCs after miR-106a/20b-mimics transfection could promote the inhibition of GSC proliferation by T cells in vitro and suppress tumour growth in vivo.
other	36157872	hsa-mir-326	Carcinoma, Hepatocellular	CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.
other	36157872	hsa-mir-424	Carcinoma, Hepatocellular	CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.
circulation_biomarker_prognosis_up	36157872	hsa-mir-511	Carcinoma, Hepatocellular	AIM: To assess the role of circulating miRNAs-326, miRNA-424, and miRNA-511 in Egyptian HCC patients.
other	36157551	hsa-mir-423	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups. In the validation cohort, only miR-21 and miR-423 could be confirmed as potential HCC biomarkers.
other	36157551	hsa-mir-320d	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups.
other	36157551	hsa-mir-21	Carcinoma, Hepatocellular	In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups.
other	36157524	hsa-mir-3682	Carcinoma, Hepatocellular	3p may represent a novel therapeutic strategy for HCC.
other	36157241	hsa-mir-26a	Stomach Neoplasms	Finally, we determined that the Taurine Upregulated 1 (TUG1)/hsa-miR-26a-5p/EIF4G2 axis was the most likely regulatory pathway involved in GC development. The TUG1/hsa-miR-26a-5p axis is a likely upstream regulatory mechanism of EIF4G2 in GC.
other	36157234	hsa-mir-375	Carcinoma, Hepatocellular	lncRNA TINCR Regulates Proliferation and Invasion of Hepatocellular Carcinoma Cells by Regulating the miR-375/ATG7 Axis.
lncRNA target	36157217	hsa-mir-520g	Triple Negative Breast Neoplasms	TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC.
lncRNA target	36157217	hsa-mir-520h	Triple Negative Breast Neoplasms	TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC.
genetics_overexpression_promote	36156852	hsa-mir-506	Colorectal Neoplasms	AKT2 overexpression or miR
target gene	36156333	hsa-mir-506	Breast Neoplasms	MicroRNA-506 ameliorates breast cancer-induced osteolytic bone metastasis via the NFATc-1 signaling pathway.
lncRNA target	36156291	hsa-mir-599	Angelman Syndrome	CONCLUSION: Our findings illustrated that curcumin exhibited anti-AS effect through the miR-599/MYD88 axis and thereby inhibiting the NF-kappaB pathway.
lncRNA target	36156150	hsa-let-7b	Breast Neoplasms	Expression of SMUG1 and hsa-let-7b-5p were negatively correlated in breast cancer and we found an inhibitory auto-regulatory loop between SMUG1 and hsa-let-7b-5p in the MCF7 breast cancer cells.
other	36155856	hsa-mir-196a-2	Abortion, Septic	hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Estimation of the Odds Ratios indicated that the chance of recurrent abortions in TT genotypes of miRNA196a-2 was about three times more likely than CC in non-infected individuals and about five times more likely than CC in M.
other	36155856	hsa-mir-196a-2	Hodgkin Disease	hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Our results proposed the role of miRNA196a-2 genotypes in RPL either in M.
circulation_biomarker_diagnosis_up	36155776	hsa-mir-515	Pre-Eclampsia	5p may play critical roles in the pathogenesis of preeclampsia through suppression of XIAP, and serum miR
genetics_overexpression_promote	36155610	hsa-mir-10a	Pancreatitis	Finally, rescue experiments proved that KLF4 overexpression or miR-10a-5p suppression enhanced pyroptosis of AP acinar cells. Overall, USP25 stabilized KLF4 expression through deubiquitination, limited miR-10a-5p expression, and increased GSDMD expression, finally promoting pyroptosis of acinar cells in AP.
exosome	36155593	hsa-mir-193b	Seminoma	Taken together, these findings indicate that exosomal miR-193b-3p regulates the chemosensitivity of TCam-2 cells to cisplatin through ZBTB7A signaling and could be a promising drug target for patients with chemoresistant seminoma.
circulation_biomarker_diagnosis_up	36155522	hsa-mir-146a	Cognitive Dysfunction	OBJECTIVE: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n = 12), people with mild cognitive impairment (MCI, n = 9), and normocognitive group (CTRL, n = 18).
genetics_knock down_promote	36155410	hsa-mir-199a	Intervertebral Disc Degeneration	CDKN1B knockdown partially abrogated the effects of miR-199a-5p inhibition on DNPC proliferation and apoptosis.
circRNA target	36155326	hsa-mir-625	Squamous Cell Carcinoma of Head and Neck	5p/STAT3 axis to activate JAK/STAT3 signaling pathway, consequently facilitating OSCC cell proliferation and inhibiting cell apoptosis.
lncRNA target	36155216	hsa-mir-6499	Liver Cirrhosis	CONCLUSION: Sal B suppresses HSC activation and liver fibrosis via regulation of miR3p/LncRNA-ROR-mediated NF-kappaB signaling pathway.
lncRNA target	36155181	hsa-mir-21	Pulmonary Fibrosis	Treatment with either NaHS or BM-MSC leads to an inhibitory effect on pulmonary fibrosis as evidenced by improvement of histopathological studies, pulmonary function tests, reduction of inflammatory and fibrotic markers like Hydroxyproline, TNF alpha, TGF-beta and caspase -3 together with downregulation miR-21 and increase lncRNA-GAS5 expression. SIGNIFICANCE: The current work revealed the inhibitory effect of combined NaHS and BM-MSC on pulmonary fibrosis with concomitant modulation of miR-21 and lncRNA-GAS5 expression.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-181c	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-34a	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
circulation_biomarker_diagnosis_down	36155067	hsa-mir-29b	Alzheimer Disease	CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis.
other	36154667	hsa-mir-486	Diabetic Nephropathies	5p-CSF2RB presents a biomarker axis to the occurrence and development of DN.
other	36154667	hsa-mir-155	Diabetic Nephropathies	5p-CSF2RB presents a biomarker axis to the occurrence and development of DN.
other	36154076	hsa-let-7g	Liver Neoplasms	In an aggressive MYC-driven liver cancer model relevant to hepatocytes, 5A2-SC8 LNPs carrying let-7g miRNA were able to significantly extend survival up to 121 days.
genetics_knock down_promote	36153644	hsa-mir-16	Sepsis	Knockdown of miR
genetics_overexpression_promote	36153605	hsa-mir-1286	Osteosarcoma	OS cell progression was suppressed by miR-1286 overexpression via downregulating MAFB.
lncRNA target	36153499	hsa-mir-155	Pre-Eclampsia	CONCLUSION: LINC00240 inhibited symptoms of preeclampsia through regulation on miR-155/Nrf2 axis, which suppressed oxidative stress-induced pyroptosis to improve trophoblast function and M2 macrophage polarization.
lncRNA target	36153449	hsa-mir-126	Brain Ischemia	OBJECTIVE: To observe the effect of electroacupuncture (EA) on miRNA3p and mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway in rats with cerebral ischemia (CI), so as to explore the underlying mechanism of EA on angiogenesis.
lncRNA target	36153434	hsa-mir-770	Diabetic Nephropathies	CONCLUSIONS: These results suggest that circ ASAP2 decreased inflammation and ferroptosis in DN through SOX2/SLC7A11 by miR
other	36153426	hsa-mir-664b	Alzheimer Disease	Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure.
other	36153426	hsa-mir-651	Alzheimer Disease	Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure.
lncRNA target	36153370	hsa-mir-648	Stomach Neoplasms	Our studies suggest that miR-3648 acts as a tumour-suppressive miRNA and that the miR-3