category	mir	disease	pmid	description
epigenetics	hsa-mir-195	"Carcinoma, Hepatocellular"	17188425	"miRNA-195 expression is decreased in HCC compared to nontumor liver [59], and is also deleted in lung cancer [65], suggesting it is tumor related. miRNA-195 alters the expression of methyl-CpG binding protein 2 (which alters DNA methylation), the SKI oncogene, and a Bcl-2 like protein [59], suggesting miRNA-195 may act as a tumor suppressor in HCC."
epigenetics	hsa-mir-127	Colon Neoplasms	17355635	"Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene."
epigenetics	hsa-mir-127	Prostate Neoplasms	17355635	"Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene."
epigenetics	hsa-mir-127	Urinary Bladder Cancer	17355635	"Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene."
epigenetics	hsa-mir-29a	Lung Neoplasms	17890317	"mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B."
epigenetics	hsa-mir-29b	Lung Neoplasms	17890317	MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
epigenetics	hsa-mir-29b-1	Lung Neoplasms	17890317	"mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B."
epigenetics	hsa-mir-29c	Lung Neoplasms	17890317	"mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B."
epigenetics	hsa-mir-34b	Colorectal Carcinoma	18519671	"Our results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC."
epigenetics	hsa-mir-34c	Colorectal Carcinoma	18519671	"Our results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC."
epigenetics	hsa-mir-1	Cardiomegaly	18539123	"Microinjecting fragments of either the coding region or the related microRNA miR-1 led to high levels of expression of homologous RNA, resulting in an epigenetic defect, cardiac hypertrophy, whose efficient hereditary transmission correlated with the presence of miR-1 in the sperm nucleus."
epigenetics	hsa-mir-34a	Neoplasms [unspecific]	18719384	"miR-34a: inactivation, Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer"
epigenetics	hsa-mir-34b	Neoplasms [unspecific]	18768788	miR-34b: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues
epigenetics	hsa-mir-34c	Neoplasms [unspecific]	18768788	miR-34c: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues
epigenetics	hsa-mir-9-1	Neoplasms [unspecific]	18768788	miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues
epigenetics	hsa-mir-9-2	Neoplasms [unspecific]	18768788	miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues
epigenetics	hsa-mir-9-3	Neoplasms [unspecific]	18768788	miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues
epigenetics	hsa-mir-126	Neoplasms [unspecific]	19116145	miR-126: a tumor supressor: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7
epigenetics	hsa-mir-29b-1	"Leukemia, Myeloid, Acute"	19211935	miR-29b: induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
epigenetics	hsa-mir-29b-2	"Leukemia, Myeloid, Acute"	19211935	miR-29b: induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
epigenetics	hsa-mir-107	Pancreatic Neoplasms	19407485	Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer.
epigenetics	hsa-mir-512	Gastric Neoplasms	19503096	Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells.
epigenetics	hsa-mir-22	"Leukemia, Lymphoblastic, Acute"	19807731	"Thus, accumulation of H3K27triM independent of promoter DNA methylation may be a novel epigenetic mechanism for MIR22 silencing in ALL."
epigenetics	hsa-mir-124-1	"Carcinoma, Hepatocellular"	19843643	miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
epigenetics	hsa-mir-124-2	"Carcinoma, Hepatocellular"	19843643	miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
epigenetics	hsa-mir-124-3	"Carcinoma, Hepatocellular"	19843643	miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
epigenetics	hsa-mir-203	"Carcinoma, Hepatocellular"	19843643	miR-203:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
epigenetics	hsa-mir-212	Gastric Neoplasms	20020497	miR-212:miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer
epigenetics	hsa-mir-193b	Prostate Neoplasms	20073067	miR-193b:miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer
epigenetics	hsa-mir-181c	Gastric Neoplasms	20080834	miR-181c:Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis.
epigenetics	hsa-mir-137	"Squamous Cell Carcinoma, Oral"	20197299	miR-137:MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index
epigenetics	hsa-mir-148a	Lung Neoplasms	20431052	miR-148a:The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis
epigenetics	hsa-mir-124-1	Myelodysplastic Syndromes	20448201	miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
epigenetics	hsa-mir-124-2	Myelodysplastic Syndromes	20448201	miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
epigenetics	hsa-mir-124-3	Myelodysplastic Syndromes	20448201	miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
epigenetics	hsa-mir-27a	Pancreatic Neoplasms	20488920	"microRNA-27a:Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a"
epigenetics	hsa-mir-206	Waldenstrom Macroglobulinemia	20519629	miR-206:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9
epigenetics	hsa-mir-9-1	Waldenstrom Macroglobulinemia	20519629	miR-9:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9
epigenetics	hsa-mir-9-2	Waldenstrom Macroglobulinemia	20519629	miR-9:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9
epigenetics	hsa-mir-152	"Carcinoma, Hepatocellular"	20578129	microRNA-152:a tumor-suppressive role of miR-152 in the epigenetic aberration of HBV-related HCC
epigenetics	hsa-mir-181b-1	Inflammation	20797623	miR-181b-1:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
epigenetics	hsa-mir-181b-1	Neoplasms [unspecific]	20797623	miR-181b-1:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
epigenetics	hsa-mir-21	Inflammation	20797623	miR-21:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
epigenetics	hsa-mir-21	Neoplasms [unspecific]	20797623	miR-21:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
epigenetics	hsa-mir-34b	Gastric Neoplasms	20924086	"These results suggest that miR-34b and miR-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR-34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk."
epigenetics	hsa-mir-34c	Gastrointestinal Neoplasms	20924086	"These results suggest that miR-34b and miR-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR-34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk."
epigenetics	hsa-mir-375	Breast Neoplasms	20978187	Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells.
epigenetics	hsa-mir-212	Gastrointestinal Neoplasms	21053104	"The conclusion could be deduced from the study that decreased expression of miR-212 may be due to hypermethylation of CPI in gastric cancer cells, and miR-212 might act on the progression of gastric cancer through the potential target gene Myc."
epigenetics	hsa-mir-1224	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-1227	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-1229	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-149	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-210	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-212	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-328	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-503	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-9-1	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-9-2	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-9-3	Urinary Bladder Cancer	21138856	hypermethylation was more frequent and dense in CpG shores than islands
epigenetics	hsa-mir-373	Cholangiocarcinoma	21165562	Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar Cholangiocarcinoma.
epigenetics	hsa-mir-126	Systemic Lupus Erythematosus	21165896	MicroRNA-126 regulates DNA methylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
epigenetics	hsa-mir-129-2	Gastric Neoplasms	21213213	"upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared with adjacent normal tissues, and their methylation status correlated inversely with their expression patterns."
epigenetics	hsa-mir-34b	Gastric Neoplasms	21213213	"upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared with adjacent normal tissues, and their methylation status correlated inversely with their expression patterns."
epigenetics	hsa-mir-34a	Breast Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	"Carcinoma, Renal Cell"	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	Colorectal Carcinoma	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	Ovarian Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	Pancreatic Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	Sarcoma [unspecific]	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34a	Urinary Bladder Cancer	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Breast Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	"Carcinoma, Renal Cell"	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Colorectal Carcinoma	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Ovarian Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Pancreatic Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Sarcoma [unspecific]	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34b	Urinary Bladder Cancer	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Breast Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	"Carcinoma, Renal Cell"	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Colorectal Carcinoma	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Ovarian Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Pancreatic Neoplasms	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Sarcoma [unspecific]	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-34c	Urinary Bladder Cancer	21225432	"Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas."
epigenetics	hsa-mir-196b	Prostate Neoplasms	21255435	"We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells."
epigenetics	hsa-mir-205	Prostate Neoplasms	21255435	"We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells."
epigenetics	hsa-mir-21	Prostate Neoplasms	21255435	"We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells."
epigenetics	hsa-mir-29b-1	Atherosclerosis	21266537	"OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases."
epigenetics	hsa-mir-29b-2	Atherosclerosis	21266537	"OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases."
epigenetics	hsa-mir-335	Breast Neoplasms	21289068	MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer.
epigenetics	hsa-mir-200b	Neoplasms [unspecific]	21292642	Depletion of miR-200 in arsenite-transformed cells involved induction of the EMT-inducing transcription factors ZEB1 (zinc-finger E-box-binding homeobox factor 1) and ZEB2 and increased methylation of miR-200 promoters.
epigenetics	hsa-mir-199a-1	Breast Neoplasms	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199a-1	"Carcinoma, Lung, Non-Small-Cell"	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199a-1	Colorectal Carcinoma	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199a-2	Breast Neoplasms	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199a-2	"Carcinoma, Lung, Non-Small-Cell"	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199a-2	Colorectal Carcinoma	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199b	Breast Neoplasms	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199b	"Carcinoma, Lung, Non-Small-Cell"	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-199b	Colorectal Carcinoma	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-34a	Breast Neoplasms	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-34a	"Carcinoma, Lung, Non-Small-Cell"	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-34a	Colorectal Carcinoma	21317930	"Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells"
epigenetics	hsa-mir-203	"Leukemia, Myeloid, Acute"	21323860	The frequent hsa-miR-203 methylation in lymphoid malignancies suggested a pathogenetic role of hsa-miR-203 methylation.
epigenetics	hsa-mir-1-1	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-1-1	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-1-1	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-1	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-1	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-1	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-2	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-2	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-2	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-3	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-3	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-124-3	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-148a	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-148a	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-148a	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-152	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-152	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-152	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-18b	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-18b	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-18b	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-200a	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-200a	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-200a	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-208a	Colorectal Carcinoma	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-208a	Endometrial Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-208a	Gastrointestinal Neoplasms	21327300	"Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;"
epigenetics	hsa-mir-145	Prostate Neoplasms	21349819	this is the first report documenting that downregulation of miR-145 is through DNA methylation and p53 mutation pathways in prostate cancer.
epigenetics	hsa-mir-124-1	Gastric Neoplasms	21365509	"Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)."
epigenetics	hsa-mir-124-2	Gastric Neoplasms	21365509	"Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)."
epigenetics	hsa-mir-124-3	Gastric Neoplasms	21365509	"Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)."
epigenetics	hsa-mir-34b	"Carcinoma, Lung, Non-Small-Cell"	21383543	DNA hypermethylation of microRNA-34b/c has prognostic value for stage ¢ñ non-small cell lung cancer.
epigenetics	hsa-mir-34c	"Carcinoma, Lung, Non-Small-Cell"	21383543	DNA hypermethylation of microRNA-34b/c has prognostic value for stage ¢ñ non-small cell lung cancer.
epigenetics	hsa-mir-199a-1	Testicular Neoplasms	21383689	"PODXL is a downstream effector mediating the action of miR199a-5p. This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy."
epigenetics	hsa-mir-199a-2	Testicular Neoplasms	21383689	"PODXL is a downstream effector mediating the action of miR199a-5p. This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy."
epigenetics	hsa-mir-193a	"Leukemia, Myeloid, Acute"	21399664	MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia.
epigenetics	hsa-mir-137	"Squamous Cell Carcinoma, Head and Neck"	21425146	MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck.
epigenetics	hsa-mir-203	Lymphoma	21454413	Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis.
epigenetics	hsa-mir-203	Urinary Bladder Cancer	21461574	hypermethylation of miR-124a and miR-203 in the precursor lesions compared to the control samples
epigenetics	hsa-mir-181a-2	"Carcinoma, Hepatocellular"	21464043	"HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM."
epigenetics	hsa-mir-181b-1	"Carcinoma, Hepatocellular"	21464043	"HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM."
epigenetics	hsa-mir-181b-2	"Carcinoma, Hepatocellular"	21464043	"HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM."
epigenetics	hsa-mir-181c	"Carcinoma, Hepatocellular"	21464043	"HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM."
epigenetics	hsa-mir-181d	"Carcinoma, Hepatocellular"	21464043	"HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM."
epigenetics	hsa-mir-375	Esophageal Neoplasms	21533613	Epigenetic Silencing of MicroRNA-375 Regulates PDK1 Expression in Esophageal Cancer
epigenetics	hsa-mir-126	Systemic Lupus Erythematosus	21538319	MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
epigenetics	hsa-mir-24-1	"Leukemia, Myeloid, Acute"	21544199	miR-124-1 is epigenetically inactivated in Haematological Malignancies.
epigenetics	hsa-mir-24-1	Lymphoma	21544199	miR-124-1 is epigenetically inactivated in Haematological Malignancies.
epigenetics	hsa-mir-24-1	Multiple Myeloma	21544199	miR-124-1 is epigenetically inactivated in Haematological Malignancies.
epigenetics	hsa-mir-129-2	Esophageal Neoplasms	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-129-2	"Squamous Cell Carcinoma, Esophageal"	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34a	Esophageal Neoplasms	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34a	"Squamous Cell Carcinoma, Esophageal"	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34b	Esophageal Neoplasms	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34b	"Squamous Cell Carcinoma, Esophageal"	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34c	Esophageal Neoplasms	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-34c	"Squamous Cell Carcinoma, Esophageal"	21547903	"The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)."
epigenetics	hsa-mir-10b	Gastric Neoplasms	21562367	"miR-10b methylation may be a useful molecular biomarker for assessing the risk of gastric cancer development, and modulation of miR-10b may represent a therapeutic approach for treating gastric cancer."
epigenetics	hsa-mir-34b	Colorectal Carcinoma	21610744	Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer.
epigenetics	hsa-mir-34c	Colorectal Carcinoma	21610744	Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer.
epigenetics	hsa-mir-132	Pancreatic Neoplasms	21665894	Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
epigenetics	hsa-mir-345	Colorectal Carcinoma	21665895	"MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer."
epigenetics	hsa-mir-34b	Mesothelioma	21673066	Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma.
epigenetics	hsa-mir-34c	Mesothelioma	21673066	Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma.
epigenetics	hsa-mir-221	Breast Neoplasms	21673316	TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer.
epigenetics	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	21692953	The CC genotype of the miR-196a-2 rs11614913 polymorphism is associated with increased risk of HCC development in this Turkish population.
epigenetics	hsa-mir-126	"Carcinoma, Lung, Non-Small-Cell"	21702040	mir-34b and mir-126 were silenced by DNA methylation.
epigenetics	hsa-mir-34b	"Carcinoma, Lung, Non-Small-Cell"	21702040	mir-34b and mir-126 were silenced by DNA methylation.
epigenetics	hsa-mir-143	"Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic"	21706045	Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression.
epigenetics	hsa-mir-373	Liver Neoplasms	21706058	"Thus, histone deacetylation of CDH1 and downregulation of miR-373, together with the previously demonstrated hypermethylation of CDH1 by HBx, may be important for the understanding of HBV-related carcinogenesis."
epigenetics	hsa-mir-203	Multiple Myeloma	21707582	MIR203 is epigeneticlly silenced in multiple myeloma.
epigenetics	hsa-mir-373	Colorectal Carcinoma	21785829	Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer.
epigenetics	hsa-mir-200a	"Carcinoma, Hepatocellular"	21837748	The histone deacetylase 4/Sp1/miR-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma.
epigenetics	hsa-mir-152	Endometrial Neoplasms	21868754	miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.
epigenetics	hsa-mir-17	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-18	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-19a	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-19b-1	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-20a	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-92-1	"Leukemia, Myeloid, Acute"	21897363	We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states.
epigenetics	hsa-mir-124-1	Gastric Neoplasms	21914401	The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma.
epigenetics	hsa-mir-34b	Gastric Neoplasms	21914401	The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma.
epigenetics	hsa-mir-34c	Gastric Neoplasms	21914401	The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma.
epigenetics	hsa-mir-124-2	"Carcinoma, Lung, Non-Small-Cell"	21917081	"The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit."
epigenetics	hsa-mir-124-3	"Carcinoma, Lung, Non-Small-Cell"	21917081	"The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit."
epigenetics	hsa-mir-9-3	"Carcinoma, Lung, Non-Small-Cell"	21917081	"The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit."
epigenetics	hsa-mir-139	Gastric Neoplasms	21925125	HER2 Interacts with CD44 to Upregulate CXCR4 via Epigenetic Silencing of microRNA-139 in Gastric Cancer Cells.
epigenetics	hsa-mir-9-1	Gastric Neoplasms	21931274	"In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment."
epigenetics	hsa-mir-9-2	Gastric Neoplasms	21931274	"In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment."
epigenetics	hsa-mir-9-3	Gastric Neoplasms	21931274	"In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment."
epigenetics	hsa-mir-129-1	Thyroid Neoplasms	21946411	"Two HDACi, Trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death. In addition, miR-129-5p alone was sufficient to induce cell death and knockdown experiments showed that expression of this miRNA was required for HDACi-induced cell death. Moreover, miR-129-5p was also able to improve the anti-proliferative effects of other cancer drugs such as etoposide or HAMLET (human alpha lactalbumin made letal for tumor cells). Taken together, the data show that miR-129-5p is involved in the antitumor activity of HDACi and highlight that miRNA-driven cell death may be an efficient approach to cancer treatment."
epigenetics	hsa-mir-129-2	Thyroid Neoplasms	21946411	"Two HDACi, Trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death. In addition, miR-129-5p alone was sufficient to induce cell death and knockdown experiments showed that expression of this miRNA was required for HDACi-induced cell death. Moreover, miR-129-5p was also able to improve the anti-proliferative effects of other cancer drugs such as etoposide or HAMLET (human alpha lactalbumin made letal for tumor cells). Taken together, the data show that miR-129-5p is involved in the antitumor activity of HDACi and highlight that miRNA-driven cell death may be an efficient approach to cancer treatment."
epigenetics	hsa-mir-129-2	Gastric Neoplasms	21960261	"The methylation-silenced expression of the miRNA could be reactivated in gastric cancer cells by treatment with demethylating drugs in a time-dependent manner.Analysis of the methylation status of these miRNAs showed that the upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared to adjacent normal tissues, and their methylation status correlated inversely with their expression patterns. The expression of miR-34b and miR-129-3p was downregulated by DNA hypermethylation in primary gastric cancers, and the low expression was associated with poor clinicopathological features."
epigenetics	hsa-mir-34b	Gastric Neoplasms	21960261	"The methylation-silenced expression of the miRNA could be reactivated in gastric cancer cells by treatment with demethylating drugs in a time-dependent manner.Analysis of the methylation status of these miRNAs showed that the upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared to adjacent normal tissues, and their methylation status correlated inversely with their expression patterns. The expression of miR-34b and miR-129-3p was downregulated by DNA hypermethylation in primary gastric cancers, and the low expression was associated with poor clinicopathological features."
epigenetics	hsa-mir-185	Glioma	21962230	MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma.
epigenetics	hsa-let-7e	Breast Neoplasms	21969366	Jumonji/Arid1 B (JARID1B) promotes breast tumor cell cycle progression through epigenetic repression of micro RNA let-7e.
epigenetics	hsa-mir-191	"Carcinoma, Hepatocellular"	21969817	Hypomethylation of the hsa-miR-191 Locus Causes High Expression of hsa-miR-191 and Promotes the Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.
epigenetics	hsa-mir-34b	"Carcinoma, Lung, Small-Cell"	22047961	Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.
epigenetics	hsa-mir-34c	"Carcinoma, Lung, Small-Cell"	22047961	Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.
epigenetics	hsa-mir-29a	Influenza	22072783	Epigenetic Changes Mediated by miR29 Activate Cyclooxygenase-2 and Interferon Production during Viral Infection.
epigenetics	hsa-mir-34c	Breast Neoplasms	22074923	MiR-34c down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells.
epigenetics	hsa-mir-34b	Neoplasms [unspecific]	22082000	"miR-34b/c were homozygously methylated in HEL cells but heterozygously in MEG-01. In HEL cells, homozygous miR-34b/c methylation was associated with miR silencing, and 5-aza-2'-deoxycytidine treatment led to re-expression of both miR-34b and miR-34c, consistent with that both miRs are under the regulation of the same promoter CpG island. miR-34a was heterozygously methylated in MEG-01 and K-562. miR-203 was completely unmethylated in K-562 and SET-2 but no MSP amplification was found in both HEL and MEG-01, suggestive of miR deletion. In primary samples, four each had miR-34b/c and -203 methylation, in which two had concomitant methylation of miR-34b/c and -203. miR-34a was methylated in one patient and none had methylation of miR-124-1."
epigenetics	hsa-mir-34c	Neoplasms [unspecific]	22082000	"miR-34b/c were homozygously methylated in HEL cells but heterozygously in MEG-01. In HEL cells, homozygous miR-34b/c methylation was associated with miR silencing, and 5-aza-2'-deoxycytidine treatment led to re-expression of both miR-34b and miR-34c, consistent with that both miRs are under the regulation of the same promoter CpG island. miR-34a was heterozygously methylated in MEG-01 and K-562. miR-203 was completely unmethylated in K-562 and SET-2 but no MSP amplification was found in both HEL and MEG-01, suggestive of miR deletion. In primary samples, four each had miR-34b/c and -203 methylation, in which two had concomitant methylation of miR-34b/c and -203. miR-34a was methylated in one patient and none had methylation of miR-124-1."
epigenetics	hsa-mir-369	"Leukemia, Myeloid, Chronic"	22089542	"The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation."
epigenetics	hsa-mir-410	"Leukemia, Myeloid, Chronic"	22089542	"The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation."
epigenetics	hsa-mir-615	"Leukemia, Myeloid, Chronic"	22089542	"The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation."
epigenetics	hsa-mir-663a	"Leukemia, Myeloid, Chronic"	22089542	"The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation."
epigenetics	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	22096249	"Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia."
epigenetics	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	22096249	"Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia."
epigenetics	hsa-mir-16-2	"Leukemia, Lymphocytic, Chronic, B-Cell"	22096249	"Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia."
epigenetics	hsa-mir-29b-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	22096249	"Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia."
epigenetics	hsa-mir-29b-2	"Leukemia, Lymphocytic, Chronic, B-Cell"	22096249	"Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia."
epigenetics	hsa-mir-212	"Carcinoma, Lung, Non-Small-Cell"	22110741	"We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease."
epigenetics	hsa-mir-193a	"Carcinoma, Hepatocellular"	22117060	DNA methylation regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via SRSF2.
epigenetics	hsa-mir-127	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-137	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-141	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-200a	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-200c	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-375	"Carcinoma, Oral"	22132151	"MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers."
epigenetics	hsa-mir-9-1	"Squamous Cell Carcinoma, Oral"	22133638	Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas.
epigenetics	hsa-mir-9-3	"Squamous Cell Carcinoma, Oral"	22133638	Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas.
epigenetics	hsa-mir-148a	Gastric Neoplasms	22167392	MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer.
epigenetics	hsa-mir-29b	Cardiovascular Diseases [unspecific]	22226905	This article is part of a Special Issue entitled OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: Novel mechanisms for cardiovascular diseases.
epigenetics	hsa-mir-200b	Breast Neoplasms	22231446	Methylation of functional promoters of the Hsa-mir-200b is associated with metastasis or hormone receptor status in advanced breast cancer.
epigenetics	hsa-mir-519d	"Carcinoma, Hepatocellular"	22262409	"In hepatocellular carcinoma miR-519d is upregulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2."
epigenetics	hsa-mir-125b-1	Breast Neoplasms	22277129	"We observed a significant reduction on the expression of miR-125b1 in cancer cells in comparison with controls, suggesting that DNA methylation at the CpG island might reduce miR-125b1 expression."
epigenetics	hsa-mir-193a	"Carcinoma, Lung, Non-Small-Cell"	22282464	Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers.
epigenetics	hsa-mir-9-3	"Carcinoma, Lung, Non-Small-Cell"	22282464	Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers.
epigenetics	hsa-mir-31	Breast Neoplasms	22289355	miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer.
epigenetics	hsa-mir-152	Atherosclerosis	22295098	MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor ¦Á gene.
epigenetics	hsa-mir-17	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-18a	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-19a	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-19b-1	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-20a	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-92a-1	Colorectal Carcinoma	22308110	Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster.
epigenetics	hsa-mir-132	Prostate Neoplasms	22310291	DNA methylation silences miR-132 in prostate cancer.
epigenetics	hsa-mir-34a	Prostate Neoplasms	22347519	Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment.
epigenetics	hsa-let-7c	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-101-1	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-125b-1	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-125b-2	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-139	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-200b	"Carcinoma, Hepatocellular"	22370893	"Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis."
epigenetics	hsa-mir-675	Eosinophilic Esophagitis	22391115	EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation.
epigenetics	hsa-mir-203	Breast Neoplasms	22393463	Epigenetic Silencing of miR-203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells.
epigenetics	hsa-mir-199b	Medulloblastoma	22411914	"The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma."
epigenetics	hsa-mir-224	"Carcinoma, Hepatocellular"	22459148	MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms.
epigenetics	hsa-let-7b	Liver Neoplasms	22683924	Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines.
epigenetics	hsa-mir-137	Gastric Neoplasms	22703336	"Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis"
epigenetics	hsa-mir-210	Gastric Neoplasms	22703336	"Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis"
epigenetics	hsa-mir-34b	Gastric Neoplasms	22703336	"Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis"
epigenetics	hsa-mir-9-1	Gastric Neoplasms	22703336	"Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis"
epigenetics	hsa-mir-9-3	Gastric Neoplasms	22703336	"Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis"
epigenetics	hsa-mir-218-1	Breast Neoplasms	22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.
epigenetics	hsa-mir-218-2	Breast Neoplasms	22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.
epigenetics	hsa-mir-7-1	Breast Neoplasms	22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.
epigenetics	hsa-mir-7-2	Breast Neoplasms	22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.
epigenetics	hsa-mir-7-3	Breast Neoplasms	22705304	miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer.
epigenetics	hsa-mir-1-1	Colorectal Carcinoma	22766685	Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer.
epigenetics	hsa-mir-133a-1	Colorectal Carcinoma	22766685	Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer.
epigenetics	hsa-mir-133a-2	Colorectal Carcinoma	22766685	Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer.
epigenetics	hsa-mir-340	Neuroblastoma	22797059	miR-340 is upregulated by demethylation of an upstream genomic region that occurs during the process of neuroblastoma cell differentiation induced by all-trans retinoic acid (ATRA).
epigenetics	hsa-mir-1256	Prostate Neoplasms	22805767	Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion.
epigenetics	hsa-mir-29a	Prostate Neoplasms	22805767	Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion.
epigenetics	hsa-mir-124-1	Cholangiocarcinoma	22819820	Epigenetic regulation of miR-124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3.
epigenetics	hsa-mir-124-2	Cholangiocarcinoma	22819820	Epigenetic regulation of miR-124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3.
epigenetics	hsa-mir-149	Colorectal Carcinoma	22821729	SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer.
epigenetics	hsa-mir-205	Prostate Neoplasms	22869146	Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer.
epigenetics	hsa-mir-124a	Colorectal Carcinoma	22870149	The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs.
epigenetics	hsa-mir-34b	Colorectal Carcinoma	22870149	The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs.
epigenetics	hsa-mir-34c	Colorectal Carcinoma	22870149	The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs.
epigenetics	hsa-mir-141	Esophageal Neoplasms	22921431	Inhibition of SOX17 by MicroRNA-141 and Methylation Activates the WNT Signaling Pathway in Esophageal Cancer.
epigenetics	hsa-mir-31	Melanoma	22948084	Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.
epigenetics	hsa-mir-127	Osteosarcoma	22957032	"Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma."
epigenetics	hsa-mir-411	Osteosarcoma	22957032	"Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma."
epigenetics	hsa-mir-431	Osteosarcoma	22957032	"Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma."
epigenetics	hsa-mir-432	Osteosarcoma	22957032	"Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma."
epigenetics	hsa-mir-23b	Prostate Neoplasms	23074286	miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
epigenetics	hsa-mir-29b-1	Multiple Myeloma	23100393	DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma
epigenetics	hsa-mir-29b-2	Multiple Myeloma	23100393	DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma
epigenetics	hsa-mir-200a	Breast Neoplasms	23112837	the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer
epigenetics	hsa-mir-200b	Breast Neoplasms	23112837	the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer
epigenetics	hsa-mir-200c	Breast Neoplasms	23112837	the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer
epigenetics	hsa-mir-149	Colorectal Carcinoma	23115050	Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer
epigenetics	hsa-mir-137	"Squamous Cell Carcinoma, Oral"	23121285	MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma
epigenetics	hsa-mir-101-1	Hepatitis B Virus Infection	23124077	miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
epigenetics	hsa-mir-101-2	Hepatitis B Virus Infection	23124077	miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
epigenetics	hsa-mir-29b-1	Systemic Lupus Erythematosus	23142053	MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1
epigenetics	hsa-mir-29b-2	Systemic Lupus Erythematosus	23142053	MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1
epigenetics	hsa-mir-34b	Prostate Neoplasms	23147995	"miRNA-34b Inhibits Prostate Cancer through Demethylation, Active Chromatin Modifications, and AKT Pathways"
epigenetics	hsa-mir-29b-1	"Leukemia, Myeloid, Acute"	23178755	Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia
epigenetics	hsa-mir-29b-2	"Leukemia, Myeloid, Acute"	23178755	Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia
epigenetics	hsa-mir-29b-1	Ovarian Neoplasms	23179556	Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation
epigenetics	hsa-mir-29b-2	Ovarian Neoplasms	23179556	Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation
epigenetics	hsa-mir-211	Glioma	23183822	"Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis,Chemosensitivity and Radiosensitivity"
epigenetics	hsa-mir-124	Bladder Neoplasms	23200812	"Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers"
epigenetics	hsa-mir-137	Bladder Neoplasms	23200812	"Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers"
epigenetics	hsa-mir-9	Bladder Neoplasms	23200812	"Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers"
epigenetics	hsa-mir-200a	"Carcinoma, Hepatocellular"	23222811	Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma
epigenetics	hsa-mir-200b	"Carcinoma, Hepatocellular"	23222811	Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma
epigenetics	hsa-mir-200c	"Carcinoma, Hepatocellular"	23222811	Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma
epigenetics	hsa-mir-193a	"Leukemia, Myeloid, Acute"	23223432	Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21)acute myeloid leukemia by activating the PTEN/PI3K signal pathway
epigenetics	hsa-mir-335	"Carcinoma, Hepatocellular"	23229728	Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma
epigenetics	hsa-mir-31	Prostate Neoplasms	23233736	Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression
epigenetics	hsa-mir-34a	Colon Neoplasms	23243217	Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and beta-Catenin Predicts Distant Metastasis of Colon Cancer
epigenetics	hsa-mir-34a	Breast Neoplasms	23292869	Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis
epigenetics	hsa-mir-124-1	"Carcinoma, Renal Cell"	23321515	Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
epigenetics	hsa-mir-124-2	"Carcinoma, Renal Cell"	23321515	Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
epigenetics	hsa-mir-124-3	"Carcinoma, Renal Cell"	23321515	Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
epigenetics	hsa-mir-195	Gastric Neoplasms	23333942	MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer
epigenetics	hsa-mir-378a	Gastric Neoplasms	23333942	MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer
epigenetics	hsa-mir-124-1	Pancreatic Neoplasms	23334332	Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
epigenetics	hsa-mir-124-2	Pancreatic Neoplasms	23334332	Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
epigenetics	hsa-mir-124-3	Pancreatic Neoplasms	23334332	Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
epigenetics	hsa-mir-129-2	"Carcinoma, Hepatocellular"	23402613	Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC
epigenetics	hsa-mir-200	Breast Neoplasms	23525011	Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state
epigenetics	hsa-mir-146a	"Lymphoma, Burkitt"	23528241	"We concluded that similarly to the promoters of protein coding genes, both DNA methylation and histone modifications contribute to the host cell dependent expression of miR-146a."
epigenetics	hsa-mir-129-1	"Carcinoma, Hepatocellular"	23580407	Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma
epigenetics	hsa-mir-129-2	"Carcinoma, Hepatocellular"	23580407	Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma
epigenetics	hsa-mir-1286	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-1287	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-1290	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-432	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-641	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-95	Human Papilloma Virus Infection	23732000	"We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines."
epigenetics	hsa-mir-124a-2	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-124a-3	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-129-2	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-34b	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-34c	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-9-1	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-9-3	"Carcinoma, Renal Cell"	23755536	"The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue"
epigenetics	hsa-mir-29a	"Carcinoma, Hepatocellular"	23789939	miR-29a could regulate TGF-¦Â-induced EMT by affecting DNA methylation via the suppression of DNMT.
epigenetics	hsa-mir-219	Breast Neoplasms	23813567	Aberrant DNA methylation of miR-219 promoter in long-term night shiftworkers.
epigenetics	hsa-mir-10a	Bladder Neoplasms	23867826	"Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers."
epigenetics	hsa-mir-152	Bladder Neoplasms	23867826	"Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers."
epigenetics	hsa-mir-200b	Bladder Neoplasms	23867826	"Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers."
epigenetics	hsa-mir-15a	"Carcinoma, Lung, Non-Small-Cell"	23867991	Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer.
epigenetics	hsa-mir-16-1	"Carcinoma, Lung, Non-Small-Cell"	23867991	Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer.
epigenetics	hsa-mir-663	"Leukemia, Myeloid, Acute"	23870168	"Expression of miR-663 was significantly lower in pediatric AML cells compared to NBM controls; furthermore, a high frequency of miR-663 promoter hypermethylation was observed in both AML cell lines and pediatric AML samples.Inactivation of miR-663 by promoter hypermethylation could be affected by 5-Aza demethylation. These findings suggest that hypermethylation of the miR-663 promoter may be an early event in the development of pediatric AML."
epigenetics	hsa-mir-126	Colorectal Carcinoma	23900443	Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer.
epigenetics	hsa-mir-29	"Carcinoma, Lung, Non-Small-Cell"	23939044	Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.
epigenetics	hsa-mir-34b	Gastric Neoplasms	23942619	Our results suggest that methylation of miR-34b/c in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC.
epigenetics	hsa-mir-34c	Gastric Neoplasms	23942619	Our results suggest that methylation of miR-34b/c in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC.
epigenetics	hsa-mir-199a	Testicular Neoplasms	23959088	"microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer."
epigenetics	hsa-mir-126	Systemic Lupus Erythematosus	23981988	The upregulation of miR-126 and its host gene EGFL7 expression in CD4+ T cells from SLE is associated with the hypomethylation of the EGFL7 promoter.
epigenetics	hsa-mir-328	Breast Neoplasms	23991164	Methylation patterns in the miR-328 5'-flanking region are involved in the inter-individual difference in BCRP levels in human placenta
epigenetics	hsa-mir-122	"Carcinoma, Hepatocellular"	24085423	The expression of miRNA-122 is regulated by DNA methylation and correlated with apoptosis of liver cancer cells. Methylation regulation of miRNA-122 expression might be involved in the development of hepatocellular carcinoma.
epigenetics	hsa-mir-29	Neoplasms [unspecific]	24096364	The miR-29 family recurrently regulates active DNA demethylation pathway members TET1 and TDG.
epigenetics	hsa-mir-203	"Leukemia, Myeloid, Acute, Pediatric"	24103876	miR-203 may not be regulated with methylation mechanism in pediatric acute leukemia. miR- 203 may be a protooncogene involved in the formation of pediatric acute leukemia and ALL. Further analyses indicated that high expression of miR-203 may be associated with poor prognosis of pediatric ALL and acute leukemia.
epigenetics	hsa-mir-125b	Melanoma	24118912	"the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels."
epigenetics	hsa-mir-200	Hepatoblastoma	24122292	The strong correlation between expression and DNA methylation suggests a major role for this epigenetic mark in the regulation of the miR-141-200c locus.
epigenetics	hsa-mir-205	Hepatoblastoma	24122292	The strong correlation between expression and DNA methylation suggests a major role for this epigenetic mark in the regulation of the miR-141-200c locus.
epigenetics	hsa-mir-214	Lung Fibrosis	24122720	"Stable decreases in miR-124 expression contribute to an epigenetically reprogrammed, highly proliferative, migratory, and inflammatory phenotype of hypertensive pulmonary adventitial fibroblasts. Thus, therapies directed at restoring miR-124 function, including histone deacetylase inhibitors,should be investigated."
epigenetics	hsa-mir-34b	Early-Stage Lung Adenocarcinoma	24130071	Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma.
epigenetics	hsa-mir-34c	Early-Stage Lung Adenocarcinoma	24130071	Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma.
epigenetics	hsa-mir-29b	Liver Fibrosis	24138392	Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis.
epigenetics	hsa-mir-34b	Pleural Mesothelioma	24168922	"Our digital MSP assay can quantify miR-34b/c methylation in serum-circulating DNA. The degree of miR-34b/c methylation in serum-circulating DNA is associated with MPM, suggesting that this approach might be useful for the establishment of a new detection system for MPM."
epigenetics	hsa-mir-34c	Pleural Mesothelioma	24168922	"Our digital MSP assay can quantify miR-34b/c methylation in serum-circulating DNA. The degree of miR-34b/c methylation in serum-circulating DNA is associated with MPM, suggesting that this approach might be useful for the establishment of a new detection system for MPM."
epigenetics	hsa-mir-375	Prostate Neoplasms	24173286	Androgen receptor is negatively correlated with the methylation-mediated transcriptional repression of miR-375 in human prostate cancer cells.
epigenetics	hsa-mir-143	Breast Neoplasms	24218337	MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.
epigenetics	hsa-mir-124a	Rheumatoid Arthritis	24223605	"The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis."
epigenetics	hsa-mir-203	Rhabdomyosarcoma	24247238	"miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma."
epigenetics	hsa-mir-148b	Breast Neoplasms	24257477	"Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer."
epigenetics	hsa-mir-151a	Breast Neoplasms	24257477	"Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer."
epigenetics	hsa-mir-21	Breast Neoplasms	24257477	"Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer."
epigenetics	hsa-mir-29c	Breast Neoplasms	24297604	Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
epigenetics	hsa-mir-199a	Chronic Obstructive Pulmonary Disease	24299514	"miR-199a-5p is a key regulator of the unfolded protein response in AAT-deficient monocytes, and epigenetic silencing of its expression regulates this process in chronic obstructive pulmonary disease."
epigenetics	hsa-mir-124a	Melanoma	24303550	Epigenetic regulation of melanoma tumor suppressor miRNA-124a.
epigenetics	hsa-mir-128a	"Leukemia, T-Cell"	24316133	Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia jurkat cells by modulating expression of fas-associated protein with death domain (FADD).
epigenetics	hsa-mir-223	"Carcinoma, Hepatocellular"	24333181	Downregulation of miR-223 in HCC is associated with the epigenetic regulation by highly expressed sulfatide and involved in tumor metastasis.
epigenetics	hsa-mir-205	Hepatitis B Virus Infection	24339740	Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis.
epigenetics	hsa-mir-9	Medulloblastoma	24346283	microRNA-9 is a methylation-silenced tumour suppressor that could be a potential candidate predictive marker for poor prognosis of medulloblastoma.
epigenetics	hsa-mir-22	Ewing Sarcoma	24362521	The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma.
epigenetics	hsa-let-7c	Cardiomyopathy	24365598	Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications.
epigenetics	hsa-mir-99a	Cardiomyopathy	24365598	Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications.
epigenetics	hsa-mir-375	"Diabetes Mellitus, Type 2"	24366165	Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus.
epigenetics	hsa-mir-9	"Leukemia, Lymphocytic, Chronic, B-Cell"	24373626	"Of the miR-9 family, miR-9-3 is a tumor suppressor miRNA relatively frequently methylated, and hence silenced in CLL; whereas miR-9-1 methylation is rare in CLL. The role of miR-9-3 methylation in the constitutive activation of NF¦ÊB signaling pathway in CLL warrants further study."
epigenetics	hsa-mir-124a-1	Breast Neoplasms	24375250	"Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease."
epigenetics	hsa-mir-124a-2	Breast Neoplasms	24375250	"Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease."
epigenetics	hsa-mir-124a-3	Breast Neoplasms	24375250	"Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease."
epigenetics	hsa-mir-124	Pulmonary Hypertension	24385500	Deacetylation of MicroRNA-124 in fibroblasts: role in pulmonary hypertension.
epigenetics	hsa-mir-297	Squamous Cell Carcinoma	24394434	Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas.
epigenetics	hsa-mir-485	Squamous Cell Carcinoma	24394434	Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas.
epigenetics	hsa-mir-92b	Squamous Cell Carcinoma	24394434	Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas.
epigenetics	hsa-mir-34a	Bladder Neoplasms	24423412	"Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression, which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44."
epigenetics	hsa-let-7a-3	Neoplasms [unspecific]	24423609	Reduction of let-7a3/let-7b miRNA may be one of mechanisms leading to overexpression of HMGA2 in AT/RT tissues.
epigenetics	hsa-mir-1258	Lung Neoplasms	24450160	Novel miRNA genes methylated in lung tumors.
epigenetics	hsa-mir-137	Lung Neoplasms	24450160	Novel miRNA genes methylated in lung tumors.
epigenetics	hsa-mir-375	Lung Neoplasms	24450160	Novel miRNA genes methylated in lung tumors.
epigenetics	hsa-mir-21	Pancreatic Neoplasms	24460329	MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells.
epigenetics	hsa-mir-10b	Gastric Neoplasms	24481854	"Taken together, these findings suggest that miR-10b may function as a novel tumor suppressor and is partially silenced by DNA hypermethylation in GC."
epigenetics	hsa-mir-1260b	Prostate Neoplasms	24504368	Our data suggest that genistein exerts its anti-tumour effect via downregulation of miR-1260b that targeted sRRP1 and Smad4 genes in prostate cancer cells. The expression of sFRP1 and Smad4 was also modulated by genistein via DNA methylation or histone modifications in PC cell lines.
epigenetics	hsa-mir-203	"Carcinoma, Endometrial"	24530564	"Hypermethylation of miR-203 is a frequent event in endometrial carcinomas and is strongly associated with microsatellite instability and MLH1 methylation status. Thus, miR-203 methylation level might represent a marker for patients with endometrioid and clear endometrial sub-cancers."
epigenetics	hsa-mir-34a	"Leukemia, Lymphocytic, Chronic, B-Cell"	24559316	"Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study."
epigenetics	hsa-mir-34b	"Leukemia, Lymphocytic, Chronic, B-Cell"	24559316	"Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study."
epigenetics	hsa-mir-34c	"Leukemia, Lymphocytic, Chronic, B-Cell"	24559316	"Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study."
epigenetics	hsa-mir-375	"Carcinoma, Breast"	24571711	"Epigenetic silencing of miR-375 causes the upregulation of IGF1R,which at least partially underlies trastuzumab resistance of breast cancer cells.Our study has implications for miR-375 as a potential target in combination with trastuzumab for treating HER2-positive breast cancers."
epigenetics	hsa-mir-429	"Carcinoma, Hepatocellular"	24572141	"Epigenetic modification of miR-429 can manipulate liver T-ICs by targeting the RBBP4/E2F1/OCT4 axis. This miRNA might be targeted to inactivate T-ICs, thus providing a novel strategy for HCC prevention and treatment."
epigenetics	hsa-mir-199b	Ovarian Neoplasms	24659709	Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer.
epigenetics	hsa-mir-127	Lung Neoplasms	24665010	Epigenetic analysis of microRNA genes in tumors from surgically resected lung cancer patients and association with survival.
epigenetics	hsa-mir-491	Liver Neoplasms	24680928	Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491.
epigenetics	hsa-mir-34	"Leukemia, Lymphocytic, Chronic, B-Cell"	24686393	microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
epigenetics	hsa-mir-34b	"Leukemia, Lymphocytic, Chronic, B-Cell"	24686393	microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
epigenetics	hsa-mir-34c	"Leukemia, Lymphocytic, Chronic, B-Cell"	24686393	microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
epigenetics	hsa-let-7a-3	"Leukemia, Myeloid, Acute"	24703161	"MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia."
epigenetics	hsa-mir-34b	"Carcinoma, Hepatocellular"	24704024	Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer.
epigenetics	hsa-mir-148a	"Carcinoma, Hepatocellular"	24714841	MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis.
epigenetics	hsa-mir-200c	Breast Neoplasms	24729530	Induction of the mesenchymal to epithelial transition by demethylation- activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic trioxide on human breast cancer cells.
epigenetics	hsa-mir-224	Prostate Neoplasms	24737792	"The GABRE-miR-452-miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. Tumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines,suggesting that epigenetic silencing of GABRE/miR-452/miR-224 may be selected for in prostate cancer."
epigenetics	hsa-mir-452	Prostate Neoplasms	24737792	"The GABRE-miR-452-miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. Tumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines,suggesting that epigenetic silencing of GABRE/miR-452/miR-224 may be selected for in prostate cancer."
epigenetics	hsa-mir-302	"Carcinoma, Hepatocellular"	24740829	"miR-302-mediated iPSC technology reprogrammed HCC cells and improved drug sensitivity through AOF2 down-regulation, which caused H3K4 methylation and c-Myc repression."
epigenetics	hsa-mir-375	"Diabetes Mellitus, Type 2"	24741571	Ethnic differences in microRNA-375 expression level and DNA methylation status in type 2 diabetes of Han and Kazak populations.
epigenetics	hsa-mir-31	"Adenocarcinoma, Colon"	24752710	"MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions."
epigenetics	hsa-mir-615	"Adenocarcinoma, Pancreatic Ductal"	24769899	miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma.
epigenetics	hsa-mir-449a	Gastric Neoplasms	24810364	Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a.
epigenetics	hsa-mir-99a	Gastric Neoplasms	24810364	Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a.
epigenetics	hsa-mir-214	Rhabdomyosarcoma	24811402	MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis.
epigenetics	hsa-mir-34a	"Leukemia, Promyelocytic, Acute"	24811488	"Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia."
epigenetics	hsa-mir-34b	"Leukemia, Promyelocytic, Acute"	24811488	"Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia."
epigenetics	hsa-mir-34c	"Leukemia, Promyelocytic, Acute"	24811488	"Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia."
epigenetics	hsa-mir-126	Myeloma	24875904	"TNF¦Á in the marrow microenvironment led to RANKL demethylation and re-expression in myeloma cells through DNMT1 repression and upregulation of miR-126-3p and miR-140, both known to repress DNMT1 translation."
epigenetics	hsa-mir-140	Myeloma	24875904	"TNF¦Á in the marrow microenvironment led to RANKL demethylation and re-expression in myeloma cells through DNMT1 repression and upregulation of miR-126-3p and miR-140, both known to repress DNMT1 translation."
epigenetics	hsa-mir-146a	Prostate Neoplasms	24885368	"Up-regulating miR-146a expression via the hypomethylation of the miR-146a promoter by 5-Aza-CdR was correlated with delayed progression of castration-resistant prostate cancers. Moreover, site-specific DNA methylation may play an important role in miR-146a expression in androgen-dependent prostate cancer progression to androgen-independent prostate cancer and therefore provides a potentially useful biomarker for assessing drug efficacy in prostate cancer."
epigenetics	hsa-mir-15a	"Leukemia, Myeloid, Acute"	24885794	"The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukaemogenesis, however in paediatric AML we found the region to be transcriptionally repressed. In combination, our data highlights the utility of interrogating DNA methylation and microRNA in combination with underlying genetic status to provide novel insights into AML biology."
epigenetics	hsa-mir-16-1	"Leukemia, Myeloid, Acute"	24885794	"The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukaemogenesis, however in paediatric AML we found the region to be transcriptionally repressed. In combination, our data highlights the utility of interrogating DNA methylation and microRNA in combination with underlying genetic status to provide novel insights into AML biology."
epigenetics	hsa-mir-30b	Gastric Neoplasms	24913034	Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
epigenetics	hsa-mir-200	Breast Neoplasms	24918286	SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cells.
epigenetics	hsa-mir-219	Chronic Inflammatory Pain	25031391	methylation-mediated epigenetic modification of spinal miR-219 expression regulates chronic inflammatory pain by targeting CaMKII¦Ã.
epigenetics	hsa-mir-105	Neoplasms [unspecific]	25089631	A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.
epigenetics	hsa-mir-767	Neoplasms [unspecific]	25089631	A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.
epigenetics	hsa-mir-145	Chondrosarcoma	25145279	The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma.
epigenetics	hsa-mir-149	Breast Neoplasms	25156775	Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer.
epigenetics	hsa-mir-320a	Breast Neoplasms	25159093	A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer.
epigenetics	hsa-mir-200	Neoplasms [unspecific]	25178837	Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.
epigenetics	hsa-mir-210	Helicobacter pylori Infection	25187177	Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection.
epigenetics	hsa-mir-193a	Bladder Neoplasms	25188512	The DNA methylation-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer via repression of SRSF2/PLAU/HIC2 expression.
epigenetics	hsa-mir-101	Lung Neoplasms	25210796	Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
epigenetics	hsa-mir-155	"Lymphoma, Non-Hodgkin"	25211095	Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin's lymphomas.
epigenetics	hsa-mir-106b	Polycystic Ovarian Syndrome	25243570	"Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS."
epigenetics	hsa-mir-25	Polycystic Ovarian Syndrome	25243570	"Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS."
epigenetics	hsa-mir-93	Polycystic Ovarian Syndrome	25243570	"Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS."
epigenetics	hsa-mir-9	Gastric Neoplasms	25270964	Epigenetic silencing of miRNA-9 is correlated with promoter-proximal CpG island hypermethylation in gastric cancer in vitro and in vivo.
epigenetics	hsa-mir-148a	"Carcinoma, Nasopharyngeal"	25277193	Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma.
epigenetics	hsa-mir-10b	Squamous Cell Carcinoma	25312779	Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b.
epigenetics	hsa-mir-24	"Carcinoma, Nasopharyngeal"	25319395	Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation.
epigenetics	hsa-mir-129	Gastric Neoplasms	25344911	Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters.
epigenetics	hsa-mir-214	"Leukemia, Lymphocytic, Chronic, B-Cell"	25361012	"miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation."
epigenetics	hsa-mir-26a	"Leukemia, Lymphocytic, Chronic, B-Cell"	25361012	"miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation."
epigenetics	hsa-mir-34b	Breast Neoplasms	25398683	long-term shiftwork may increase the risk of breast cancer via methylation-based suppression of miR-34b and a consequent reduction in immunomediated anti-tumor capacity and support our previous findings that LAN may induce epigenetic alteration of cancer-relevant microRNAs.
epigenetics	hsa-mir-142	"Lymphoma, T-Cell"	25405321	These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.
epigenetics	hsa-mir-146a	"Lymphoma, T-Cell"	25405321	These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.
epigenetics	hsa-mir-155	"Lymphoma, T-Cell"	25405321	These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.
epigenetics	hsa-mir-181b	"Lymphoma, T-Cell"	25405321	These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.
epigenetics	hsa-mir-21	"Lymphoma, T-Cell"	25405321	These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients.
epigenetics	hsa-mir-720	"Leukemia, Myeloid, Acute"	25417880	"The expression of miR-720 in AML patients reduced significantly, and DNA methylation-mediated epigenetic silencing of miR-720 contributed to maintain the malignant characteristics of AML."
epigenetics	hsa-mir-34a	Colorectal Carcinoma	25422210	"miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation."
epigenetics	hsa-mir-106b	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-148a	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-195	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-23a	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-25	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-27a	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-375	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-378	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-497	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-93	"Carcinoma, Hepatocellular"	25424171	"DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention."
epigenetics	hsa-mir-155	Multiple Myeloma	25497370	"DNA methylation contributes to miR-155 expression in myeloma cells. Interestingly, the survival data showed an association between miR-155 expression and outcome of MM."
epigenetics	hsa-mir-141	Gastric Neoplasms	25502084	"sion of miR-200c/141 induced by TGF-¦Â in SGC-7901 cells. Our study revealed that miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment."
epigenetics	hsa-mir-155	"Carcinoma, Colon"	25502084	"miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment."
epigenetics	hsa-mir-200	Gastric Neoplasms	25502084	"sion of miR-200c/141 induced by TGF-¦Â in SGC-7901 cells. Our study revealed that miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment."
epigenetics	hsa-mir-490	"Carcinoma, Gastric"	25503559	"hypermethylation-mediated silencing of miR-490-3p reactivates SMARCD1 to confer malignant phenotypes, mechanistically linking H. pylori, chromatin remodeling, and gastric carcinogenesis."
epigenetics	hsa-mir-137	Neuroblastoma	25505154	"an epigenetic mechanism involving miR-137-mediated EZH2 repression in RSV-induced apoptosis and tumor suppression of neuroblastoma, which would provide a key potential therapeutic target in neuroblastoma treatment."
epigenetics	hsa-mir-21	"Leukemia, Myeloid, Chronic"	25575817	RBP2 epigenetically downregulated miR-21 in blast transformation of CML.
epigenetics	hsa-mir-34b	Leukemia	25582471	"The hypermethylation of promoter leads to decrease in the expression levels of miR-34b in leukemia cell lines, which attenuate mechanism of proliferative inhibition may be one of the reasons of occurrence or development of childhood leukemia."
epigenetics	hsa-mir-328	Osteosarcoma	25605016	the role of RESV-induced molecular and epigenetic regulation in suppressing tumor metastasis.
epigenetics	hsa-mir-34b	Wilms Tumor	25625843	Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation.
epigenetics	hsa-mir-142	Systemic Lupus Erythematosus	25661834	"Data from this study suggest that MPA activates miR-142 and miR-146a expression through histone modification at the promoter region, which may partially explain the pharmacological mechanisms of MPA for SLE."
epigenetics	hsa-mir-146a	Systemic Lupus Erythematosus	25661834	"Data from this study suggest that MPA activates miR-142 and miR-146a expression through histone modification at the promoter region, which may partially explain the pharmacological mechanisms of MPA for SLE."
epigenetics	hsa-mir-375	Myeloproliferative Neoplasms	25666256	Epigenetic deregulated miR-375 contributes to the constitutive activation of JAK2/STAT signaling in myeloproliferative neoplasm.
epigenetics	hsa-mir-484	Colorectal Carcinoma	25727216	Methylation-induced loss of miR-484 in microsatellite-unstable colorectal cancer promotes both viability and IL-8 production via CD137L.
epigenetics	hsa-mir-125b-2	Prostate Neoplasms	25728837	Our work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen-dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation.
epigenetics	hsa-mir-133b	Prostate Neoplasms	25728837	Our work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen-dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation.
epigenetics	hsa-mir-145	Prostate Neoplasms	25749421	A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation.
epigenetics	hsa-mir-129-2	Glioma	25772485	MiR-129-2 functions as a tumor suppressor in glioma cells by targeting HMGB1 and is down-regulated by DNA methylation.
epigenetics	hsa-mir-34b	Soft Tissue Sarcoma	25773680	Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas.
epigenetics	hsa-mir-34c	Soft Tissue Sarcoma	25773680	Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas.
epigenetics	hsa-mir-101	Glioma	25829251	MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.
epigenetics	hsa-mir-9-1	Multiple Myeloma	25855800	"Hypermethylation of miR-9-3 and miR-9-1 is tumour-specific in MM,leading to reversible miRNA silencing. Frequent methylation of miR-9-3 and miR-9-1 in cell lines, but not in primary samples, may be acquired during in vitro culture, and indicates an unimportant role of miR-9 methylation in myelomagenesis."
epigenetics	hsa-mir-9-3	Multiple Myeloma	25855800	"Hypermethylation of miR-9-3 and miR-9-1 is tumour-specific in MM,leading to reversible miRNA silencing. Frequent methylation of miR-9-3 and miR-9-1 in cell lines, but not in primary samples, may be acquired during in vitro culture, and indicates an unimportant role of miR-9 methylation in myelomagenesis."
epigenetics	hsa-mir-34a	Gastric Neoplasms	25860861	Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a.
epigenetics	hsa-mir-124	Prostate Neoplasms	25860954	Regulation and methylation of tumor suppressor miR-124 by androgen receptor in prostate cancer cells.
epigenetics	hsa-mir-29b	Gastric Neoplasms	25874772	"Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer."
epigenetics	hsa-mir-29c	Gastric Neoplasms	25874772	"Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer."
epigenetics	hsa-mir-24-2	Neoplasms [unspecific]	25943634	The conclusion drawn of hsa-miR-24-2 targeting the genes of cell survival correlated with the methylation profile and resultant transcription factor binding site gain or loss in support of absence of cell survival.
epigenetics	hsa-mir-182	Lung Neoplasms	25975295	DNA methylation occurs in the miR-182 promoter region in lung cancer cell lines. This methylation can regulate the expression level of miR-182.Further study must be conducted to explore the function of miR-182 promoter methylation in lung cancer occurrence and development.
epigenetics	hsa-mir-34b	Neoplasms [unspecific]	25979762	"although results obtained by the different DNA methylation analysis techniques are largely comparable, an appropriate correction may be necessary for stringent comparison."
epigenetics	hsa-mir-34c	Neoplasms [unspecific]	25979762	"although results obtained by the different DNA methylation analysis techniques are largely comparable, an appropriate correction may be necessary for stringent comparison."
epigenetics	hsa-mir-148a	Breast Neoplasms	25980823	Glabridin inhibits cancer stem cell-like properties of human breast cancer cells:An epigenetic regulation of miR-148a/SMAd2 signaling.
epigenetics	hsa-mir-137	Neoplasms [unspecific]	26066330	We also found that miR-137 and its host gene are epigenetically silenced in human cancer specimens and cell lines.These results support the development and testing of microRNA-based therapies (in particular based on restoring miR-137 levels) for targeting the oncogenic family of p160 SRCs in cancer.
epigenetics	hsa-mir-129-2	Lung Neoplasms	26081366	Epigenetic regulation of miR-129-2 and its effects on the proliferation and invasion in lung cancer cells.
epigenetics	hsa-mir-302c	Chondrosarcoma	26094604	Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1.
epigenetics	hsa-mir-10a	Atherosclerosis	26148682	"Methylation-specific PCR (MSP) confirmed differential CpG methylation of HOXA genes, the ER stress gene ATF4, inflammatory regulator microRNA-10a and ARHGAP25 that encodes a negative regulator of Rho GTPases involved in cytoskeleton remodeling."
epigenetics	hsa-mir-137	Glioblastoma	26187071	Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells.
epigenetics	hsa-mir-203	Melanoma	26225581	DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells.
epigenetics	hsa-mir-210	Cardiovascular Diseases [unspecific]	26254226	Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210.
epigenetics	hsa-mir-145	"Squamous Cell Carcinoma, Esophageal"	26254350	Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinoma.
epigenetics	hsa-mir-139	"Carcinoma, Lung, Non-Small-Cell"	26256448	Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer.
epigenetics	hsa-let-7	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-106a	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-106b	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-15a	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-16	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-17	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-19b	Neoplasms [unspecific]	26303212	Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review.
epigenetics	hsa-mir-148	Hematologic Neoplasms	26314468	"This article summarizes the expression of miR-148/152 family in hematological malignancies, aiming at expounding the signicance of relationship between DNA methylation modification and microRNA."
epigenetics	hsa-mir-152	Hematologic Neoplasms	26314468	"This article summarizes the expression of miR-148/152 family in hematological malignancies, aiming at expounding the signicance of relationship between DNA methylation modification and microRNA."
epigenetics	hsa-mir-20a	Glioma	26337869	"In summary, DNMT1 mediated chemosensitivity by reducing methylation of the microRNA-20a promoter in glioma cells."
epigenetics	hsa-mir-125b	Neoplasms [unspecific]	26354435	"Taken together, our results demonstrated that miR-125b mediates PAR2-induced cancer cell migration by targeting Gab2 and that NSun2-dependent RNA methylation contributes to the down-regulation of miR-125b by PAR2 signaling. "
epigenetics	hsa-let-7	Glioma	26463235	epigenetic modification is a crucial mechanism for controlling the expression of miR-126 in glioma.
epigenetics	hsa-mir-126	Rheumatoid Arthritis	26464634	Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients.
epigenetics	hsa-mir-122	Germ Cell Tumor	26497383	"Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology."
epigenetics	hsa-mir-302a	Germ Cell Tumor	26497383	"Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology."
epigenetics	hsa-mir-302d	Germ Cell Tumor	26497383	"Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology."
epigenetics	hsa-mir-371	Germ Cell Tumor	26497383	"Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology."
epigenetics	hsa-mir-373	Germ Cell Tumor	26497383	"Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology."
epigenetics	hsa-mir-129-2	Breast Neoplasms	26519551	"In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors."
epigenetics	hsa-mir-129-2	Ovarian Neoplasms	26519551	"In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors."
epigenetics	hsa-mir-9-1	Breast Neoplasms	26519551	"In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors."
epigenetics	hsa-mir-9-1	Ovarian Neoplasms	26519551	"In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors."
epigenetics	hsa-mir-34b	Leukemia	26524015	"CpG island methylation of miR-34b promoter region in leukemia cell lines can decrease the expression levels of miR-34b, which is also the reason why miR-34b can reduce the inhibition of cell proliferation, thus miR-34b might be a tumor suppressor gene involved in the regulation of leukemia."
epigenetics	hsa-mir-29c	Breast Neoplasms	26539832	Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter.
epigenetics	hsa-mir-24	Colon Adenoma	26559563	"Butyrate and partial TSA reduced the expression of miR-135a, miR-135b, miR-24 and miR-let-7a (~0.5-fold, 24 h) and miR-24, miR-106b and miR-let-7a (~0.5-0.7-fold, 48 h) in LT97 cells."
epigenetics	hsa-mir-143	Vascular Disease [unspecific]	26573388	"Taken together, these findings suggest that DNMT3a is a direct target of miR-143, and that the upregulation of DNMT3 is responsible for the hypermethylation of miR-143 in Hcy-induced VSMC proliferation."
epigenetics	hsa-mir-145	"Adenocarcinoma, Lung"	26582602	"Taken together, DNA hyper-methylation in the miR-145 promoter region reduced its expression in LAC and miR-145 expression level might serve as a novel prognostic biomarker."
epigenetics	hsa-mir-218	"Carcinoma, Esophageal"	26610476	"In conclusion, our results support that aberrant CpG hypermethylation at least partly accounts for miR-218 silencing in ESCC, which impairs its tumor-suppressive function."
epigenetics	hsa-mir-148a	Skin Neoplasms	26638007	"Taken together, the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2.Its methylation may be a potential prognostic indicator in skin cancer."
epigenetics	hsa-mir-125a	Colorectal Carcinoma	26693202	"Our results suggest that DNA hypermethylation may be involved in the inactivation of miR-125a and miR-125b in CRC, and hypermethylation of miR-125 is a potential biomarker for clinical outcome."
epigenetics	hsa-mir-125b	Colorectal Carcinoma	26693202	"Our results suggest that DNA hypermethylation may be involved in the inactivation of miR-125a and miR-125b in CRC, and hypermethylation of miR-125 is a potential biomarker for clinical outcome."
epigenetics	hsa-mir-34c	Colorectal Carcinoma	26704889	"In conclusion, our results suggested the existence of E2F1-miR-34c-SCF negative feedback loop which was interrupted by the hyper-methylation of miR-34c promoter in CRC cells and increased cell proliferation."
epigenetics	hsa-mir-140	Osteoarthritis	26723856	"Some miRNA have also been identified and more extensively characterized, such as delineation of the role played by miR-140 in chondrogenesis, followed by the discovery of numerous miRNA potentially involved in the epigenetic regulation of osteoarthritic disease."
epigenetics	hsa-mir-21	Colorectal Carcinoma	26787105	This study suggests a high frequency of miR-21 overexpression and aberrant promoter methylation in down-regulation of PTEN expression in colorectal carcinoma. Loss of PTEN may be a prognostic factor for patients with CRC.
epigenetics	hsa-mir-133a	Cardiomegaly	26830171	Phe exposure led to methylation of CpG sites within the miR-133a locus and reduced miR-133a expression in H9C2 cells
epigenetics	hsa-mir-34b	Sarcomatoid Mesothelioma	26870271	miR-34b/c was heavily methylated in 2/4 established MPM cell lines
epigenetics	hsa-mir-34c	Sarcomatoid Mesothelioma	26870271	miR-34b/c was heavily methylated in 2/4 established MPM cell lines
epigenetics	hsa-mir-34a	Ovarian Neoplasms	26879132	"We demonstrated a clinical independent role of miR-34a in epithelial ovarian cancers. Moreover, we corroborated the correlation between miR-34a expression and its promoter methylation in a large set of ovarian cancers. The inverse association between miR-34a expression and grading, p53 mutation status and dualistic tumor type classification, together with its prognostic relevance may underline the tumor-suppressive character of miR-34a in ovarian cancer."
epigenetics	hsa-mir-296	Glioblastoma	26898758	We show that miR-296-5p expression is repressed in a DNA methylation-dependent manner under conditions that promote GBM cell stemness
epigenetics	hsa-mir-378	"Leukemia, Myeloid, Chronic"	26913395	Methylation of miR-378 in Chronic Myeloid Leukemia.
epigenetics	hsa-mir-181c	Glioblastoma	26983574	Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines.
epigenetics	hsa-mir-10b	"Squamous Cell Carcinoma, Head and Neck"	27002147	DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 production leading to up-regulation of RhoGTPase and survival proteins.
epigenetics	hsa-mir-497	Hematologic Neoplasms	27075177	"Strikingly, low-dose decitabine was able to augment chemosensitivity in cancer stem cells, likely by the upregulation of miRNA-497"
epigenetics	hsa-mir-155	Lymphoma	27110708	DNA methylation regulates miR-155 expression.
epigenetics	hsa-mir-30d	Ovarian Neoplasms	27141829	TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells
epigenetics	hsa-mir-193b	"Adenocarcinoma, Esophageal"	27176876	Aberrant methylation of microRNA-193b in human Barrett's esophagus and esophageal adenocarcinoma
epigenetics	hsa-mir-141	Prostate Neoplasms	27198154	miR-200c and miR-141 are under epigenetic regulation in PCa cells.
epigenetics	hsa-mir-200c	Prostate Neoplasms	27198154	miR-200c and miR-141 are under epigenetic regulation in PCa cells.
epigenetics	hsa-mir-153	Glioblastoma	27215075	MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation.
epigenetics	hsa-mir-211	Melanoma	27237979	DNMT1 mediated promoter methylation is a mechanism of miRNA suppression in melanoma
epigenetics	hsa-mir-200b	Cervical Neoplasms	27272214	Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b
epigenetics	hsa-mir-27b	Breast Neoplasms	27363334	MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells
epigenetics	hsa-mir-19a	Breast Neoplasms	27445062	"CAP treatment of MCF-7 induced hypermethylation at the promoter CpG sites and downregulation of miR-19a, which was known as an oncomiR."
epigenetics	hsa-mir-34a	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	27450916	"Our study revealed that miR-34a promoter hypermethylation was a risk factor for LSCC, played a critical role in the disease progression and metastasis, and could serve as a poor prognostic factor for LSCC."
epigenetics	hsa-mir-375	"Carcinoma, Breast"	27466996	"MiR-375 is downregulated in MCF-7/ADM and MCF-7/PTX cells, and its downregulation is a result of promoter methylation."
epigenetics	hsa-mir-152	"Carcinoma, Breast"	27475839	DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.
epigenetics	hsa-mir-615	"Carcinoma, Hepatocellular"	27487123	"In conclusion, our findings characterize miR-615-5p as an important epigenetically silenced miRNA involved in the Rab-Ras pathway in hepatocellular carcinoma and expand our understanding of the molecular mechanism underlying hepatocarcinogenesis and metastasis."
epigenetics	hsa-let-7b	"Carcinoma, Colon"	27525719	"G9a binds with and stabilizes RelB, thereby recruiting DNA methyltransferase 3 on the Let-7b promoter and repressing its expression."
epigenetics	hsa-mir-34a	"Carcinoma, Bladder"	27557899	MicroRNA epigenetic signatures in human disease.
epigenetics	hsa-mir-34b	Bladder Neoplasms	27557899	MicroRNA epigenetic signatures in human disease.
epigenetics	hsa-mir-34c	"Carcinoma, Bladder"	27557899	MicroRNA epigenetic signatures in human disease.
epigenetics	hsa-mir-125b	Chondrosarcoma	27576314	Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma.
epigenetics	hsa-mir-429	Cholangiocarcinoma	27593557	Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma.
epigenetics	hsa-mir-17	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-18	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-19a	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-19b-1	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-20a	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-92-1	Bronchopulmonary Dysplasia	27694474	our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD
epigenetics	hsa-mir-200c	"Carcinoma, Breast"	27717206	Epigenetic silencing of miR-200c in breast cancer is associated with aggressiveness and is modulated by ZEB1.
epigenetics	hsa-mir-200	Ovarian Serous Cystadenocarcinoma	27746113	DNA methylation-regulated microRNA pathways in ovarian serous cystadenocarcinoma: A meta-analysis.
epigenetics	hsa-mir-200	"Leukemia, Myeloid, Acute"	27756750	epigenetic silencing of the miR-200 family microRNAs affects ZEB2 expression
epigenetics	hsa-mir-124	Cervical Neoplasms	27765948	Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.
epigenetics	hsa-mir-126	"Carcinoma, Hepatocellular"	27774652	METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6 -methyladenosine-dependent primary MicroRNA processing.
epigenetics	hsa-mir-149	Glioblastoma	27783537	"MicroRNA-149 is epigenetically silenced tumor-suppressive microRNA, involved in cell proliferation and downregulation of AKT1 and cyclin?D1 in human glioblastoma multiforme."
epigenetics	hsa-mir-181a	Neurodegenerative Diseases [unspecific]	27789312	PPAR¦Â/¦Ä activation protects against corticosterone-induced ER?stress?in astrocytes by inhibiting the CpG hypermethylation of?microRNA-181a.
epigenetics	hsa-mir-124a	Rheumatoid Arthritis	27824863	Demethylation of MicroRNA-124a Genes Attenuated Proliferation of Rheumatoid Arthritis Derived Fibroblast-Like Synoviocytes and Synthesis of Tumor Necrosis Factor-¦Á.
epigenetics	hsa-mir-107	"Carcinoma, Breast"	27830681	Novel miRNA genes hypermethylated in breast cancer.
epigenetics	hsa-mir-1258	"Carcinoma, Breast"	27830681	Novel miRNA genes hypermethylated in breast cancer.
epigenetics	hsa-mir-130b	"Carcinoma, Breast"	27830681	Novel miRNA genes hypermethylated in breast cancer.
epigenetics	hsa-mir-132	"Carcinoma, Breast"	27830681	Novel miRNA genes hypermethylated in breast cancer.
epigenetics	hsa-mir-137	"Carcinoma, Breast"	27830681	Novel miRNA genes hypermethylated in breast cancer.
epigenetics	hsa-mir-378a	Liver Cirrhosis	27855367	The Epigenetically-Regulated microRNA-378a Targets TGF-¦Â2 in TGF-¦Â1-Treated Hepatic Stellate Cells.
epigenetics	hsa-mir-148a	Osteoporosis	27900532	MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women.
epigenetics	hsa-mir-124	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-125b	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-127	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-132	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-137	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-148a	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-191	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-193a	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-203	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-212	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-34b	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-375	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-9	"Carcinoma, Breast"	27998789	DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression.
epigenetics	hsa-mir-149	Hematologic Neoplasms	28035377	Histone deacetylases meet microRNA-associated MMP-9 expression regulation in glucocorticoid-sensitive and -resistant cell lines.
epigenetics	hsa-mir-520c	Hematologic Neoplasms	28035377	Histone deacetylases meet microRNA-associated MMP-9 expression regulation in glucocorticoid-sensitive and -resistant cell lines.
epigenetics	hsa-mir-106b	"Adenocarcinoma, Esophageal"	28049580	Epigenetic regulation on the gene expression signature in esophagus adenocarcinoma.
epigenetics	hsa-mir-129	"Carcinoma, Urothelial"	28081549	MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma.
epigenetics	hsa-mir-663a	"Carcinoma, Urothelial"	28081549	MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma.
epigenetics	hsa-mir-200	"Carcinoma, Endometrioid Endometrial"	28088687	Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma.
epigenetics	hsa-mir-193b	Prostate Neoplasms	28143614	MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors.
epigenetics	hsa-mir-371	Testicular Germ Cell Tumor	28199193	Epigenetic and risk factors of testicular germ cell tumors: a brief review.
epigenetics	hsa-mir-373	Testicular Germ Cell Tumor	28199193	Epigenetic and risk factors of testicular germ cell tumors: a brief review.
epigenetics	hsa-mir-1	Heart Diseases [unspecific]	28209718	Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
epigenetics	hsa-mir-133	Heart Diseases [unspecific]	28209718	Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
epigenetics	hsa-mir-208	Heart Diseases [unspecific]	28209718	Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
epigenetics	hsa-mir-499	Heart Diseases [unspecific]	28209718	Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.
epigenetics	hsa-mir-137	"Carcinoma, Lung, Non-Small-Cell"	28223039	Oncogene LSD1 is epigenetically suppressed by miR-137 overexpression in human non-small cell lung cancer.
epigenetics	hsa-mir-183	"Carcinoma, Hepatocellular"	28321157	hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma.
epigenetics	hsa-mir-210	Colorectal Carcinoma	28364795	The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer.
epigenetics	hsa-mir-34	Colorectal Carcinoma	28364795	The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer.
epigenetics	hsa-mir-9	Colorectal Carcinoma	28364795	The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer.
epigenetics	hsa-mir-370	Cholangiocarcinoma	28545228	Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.
epigenetics	hsa-mir-10b	Atherosclerosis	28601079	Variability of Methylation Profiles of CpG Sites in microrNA Genes in Leukocytes and Vascular Tissues of Patients with Atherosclerosis.
epigenetics	hsa-mir-200	Lung Neoplasms	28698146	Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.
epigenetics	hsa-mir-200c	Breast Neoplasms	28724364	Tamoxifen reverses epithelial-mesenchymal transition by demethylating miR-200c in triple-negative breast cancer cells.
epigenetics	hsa-mir-21	Multiple Sclerosis	28766461	Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.
epigenetics	hsa-mir-21	Nervous System Diseases [unspecific]	28903050	Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.
epigenetics	hsa-mir-34a	Cholangiocarcinoma	28923203	Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway.
epigenetics	hsa-mir-142	"Carcinoma, Hepatocellular"	28963738	Loss-of-function of miR-142 by hypermethylation promotes TGF-¦Â-mediated tumour growth and metastasis in hepatocellular carcinoma.
epigenetics	hsa-mir-200b	Cervical Neoplasms	29077234	DNA methylation regulated microRNAs in human cervical cancer.
epigenetics	hsa-mir-342	Multiple Myeloma	29242101	Epigenetic silencing of EVL/miR-342 in multiple myeloma
epigenetics	hsa-mir-101	Glioblastoma	29251856	Studies of intragenic and distant intergenic alterations in DNA methylation will help elucidate the nature of epigenetic deregulation in glioblastoma
epigenetics	hsa-mir-29a	"Lymphoma, Burkitt"	29318382	methylation-mediated miR-29 epigenetic silencing may occur during BL development
epigenetics	hsa-mir-22	Cholangiocarcinoma	29406621	MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.
epigenetics	hsa-mir-433	Cholangiocarcinoma	29406621	MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.
epigenetics	hsa-mir-196b	Prostate Neoplasms	29536528	"CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease."
epigenetics	hsa-mir-34a	Preeclampsia	29557690	Hypomethylation of the miRNA-34a gene promoter is associated with Severe Preeclampsia
epigenetics	hsa-mir-1179	"Carcinoma, Lung, Non-Small-Cell"	29570800	DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients.
epigenetics	hsa-mir-148a	Prostate Neoplasms	29596883	miR-148a is silenced by DNA methylation and ectopic expression of miR-148a suppresses DNMT1 expression and induced apoptotic genes expression in hormone-refractory prostate cancer cells
epigenetics	hsa-mir-375	"Carcinoma, Ovarian"	29631007	Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis
epigenetics	hsa-mir-449a	"Carcinoma, Pancreatic"	29684857	MicroRNA-449a functions as a tumor suppressor in pancreatic cancer by the epigenetic regulation of ATDC expression.
epigenetics	hsa-mir-34c	Colorectal Carcinoma	29701273	SATB2 targeted by methylated miR-34c-5p suppresses proliferation and metastasis attenuating the epithelial-mesenchymal transition in colorectal cancer.
epigenetics	hsa-mir-483	"Carcinoma, Lung, Non-Small-Cell"	29717264	Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin ¦Â3.
epigenetics	hsa-mir-570	Osteosarcoma	29795113	Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma.
epigenetics	hsa-mir-1271	Gastric Neoplasms	29862663	Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer.
epigenetics	hsa-mir-155	Glioma	29885519	Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas.
epigenetics	hsa-mir-34b	Neoplasms [unspecific]	29893976	Regulation of miR-34b/c-targeted gene expression program by SUMOylation.
epigenetics	hsa-mir-34c	Neoplasms [unspecific]	29893976	Regulation of miR-34b/c-targeted gene expression program by SUMOylation.
epigenetics	hsa-mir-34	"Carcinoma, Breast"	29916548	Methylation profiles of miR34 gene family in Vietnamese patients suffering from breast and lung cancers.
epigenetics	hsa-mir-137	Endometrial Neoplasms	29955087	miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation.
epigenetics	hsa-mir-124	"Carcinoma, Cervical"	29960712	"Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer."
epigenetics	hsa-mir-145	Ovarian Neoplasms	29993160	Double-negative feedback interaction between DNA methyltransferase 3A and microRNA-145 in the Warburg effect of ovarian cancer cells.
epigenetics	hsa-mir-125a	Gastric Neoplasms	30117667	Epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in gastric cancer.
epigenetics	hsa-mir-122	"Carcinoma, Hepatocellular"	30195653	LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation.
epigenetics	hsa-mir-4532	"Carcinoma, Breast"	30202238	Downregulation of hypermethylated in cancer-1 by miR-4532 promotes adriamycin resistance in breast cancer cells.
epigenetics	hsa-mir-873	Liver Cirrhosis	30237481	MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
epigenetics	hsa-mir-486	Colorectal Carcinoma	30305607	DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/¦Â-catenin signal pathways.
epigenetics	hsa-mir-388	Gastric Neoplasms	30308487	Hypermethylation of miR-338-3p and Impact of its Suppression on Cell Metastasis Through N-Cadherin Accumulation at the Cell -Cell Junction and Degradation of MMP in Gastric Cancer.
epigenetics	hsa-mir-107	Ovarian Neoplasms	30363055	"Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis"
epigenetics	hsa-mir-1258	Ovarian Neoplasms	30363055	"Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis"
epigenetics	hsa-mir-130b	Ovarian Neoplasms	30363055	"Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis"
epigenetics	hsa-mir-203a	Ovarian Neoplasms	30363055	"Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis"
epigenetics	hsa-mir-132	"Carcinoma, Pancreatic"	30387838	Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF-¦Â-driven progression of pancreatic cancer.