category mir disease pmid root_name doid icd10cm mesh omim hpo description other hsa-mir-198 Acquired Immunodeficiency Syndrome 19148268 disease by infectious agent DOID:635 B20 D000163 609423 miR-198: miR-198 inhibits HIV-1 gene expression and replication in monocytes other hsa-mir-29a Acquired Immunodeficiency Syndrome 16236258 disease by infectious agent DOID:635 B20 D000163 609423 miRNAs expressed in T-cells can repress nef function and thus influence disease progression. other hsa-mir-29a Acquired Immunodeficiency Syndrome 19102781 disease by infectious agent DOID:635 B20 D000163 609423 miR-29a: Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication other hsa-mir-29b-1 Acquired Immunodeficiency Syndrome 16236258 disease by infectious agent DOID:635 B20 D000163 609423 miRNAs expressed in T-cells can repress nef function and thus influence disease progression. other hsa-mir-126 Acute Brucellosis 27824867 disease by infectious agent DOID:11077 A23 D002006 MicroRNA Expression Patterns of CD8+ T Cells in Acute and Chronic Brucellosis. other hsa-mir-4753 Acute Brucellosis 27824867 disease by infectious agent DOID:11077 A23 D002006 MicroRNA Expression Patterns of CD8+ T Cells in Acute and Chronic Brucellosis. other hsa-let-7e Acute Coronary Syndrome 25903651 I24.9 D054058 These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology. other hsa-mir-107 Acute Coronary Syndrome 25903651 I24.9 D054058 These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology. other hsa-mir-1-1 Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. other hsa-mir-1-2 Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. other hsa-mir-133a-1 Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. other hsa-mir-133a-2 Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. other hsa-mir-133b Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. other hsa-mir-146a Acute Coronary Syndrome 20195282 I24.9 D054058 miR-146a in PBMCs modulates Th1 function in patients with acute coronary syndrome other hsa-mir-155 Acute Coronary Syndrome 21804579 I24.9 D054058 The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome. other hsa-mir-15b Acute Coronary Syndrome 25903651 I24.9 D054058 These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology. other hsa-mir-208b Acute Coronary Syndrome 21806992 I24.9 D054058 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. other hsa-mir-223 Acute Coronary Syndrome 24202700 I24.9 D054058 Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. other hsa-mir-486 Acute Coronary Syndrome 25903651 I24.9 D054058 These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology. other hsa-mir-92b Acute Coronary Syndrome 25903651 I24.9 D054058 These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology. other hsa-let-7i Acute Ischemic Stroke 24911610 cardiovascular system disease DOID:224 I63.9 D002546 HP:0002140 Several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA may regulate leukocyte gene expression in ischemic stroke including pathways involved in immune activation,leukocyte extravasation and thrombosis. other hsa-let-7i Acute Ischemic Stroke 27784773 cardiovascular system disease DOID:224 I63.9 D002546 HP:0002140 Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. other hsa-mir-1 Acute Kidney Failure 26400542 urinary system disease DOID:3021 N17.9 D058186 HP:0001919 Ramipril reduced cardiac hypertrophy, attenuated the increase in microRNA-212 and microRNA-132, and significantly increased microRNA-133 and microRNA-1 expression. other hsa-mir-182 Acute Kidney Failure 27865759 urinary system disease DOID:3021 N17.9 D058186 HP:0001919 miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury. other hsa-mir-21 Acute Kidney Failure 27122240 urinary system disease DOID:3021 N17.9 D058186 HP:0001919 In summary, we report noninvasive detection of AKI in humans by combining the sensitivity of KIM-1 along with mechanistic potentials of miR-21, -200c, and -423. other hsa-mir-34a Acute Kidney Failure 20386864 urinary system disease DOID:3021 N17.9 D058186 HP:0001919 MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival. other hsa-mir-21 Acute Kidney Failure 24214874 urinary system disease DOID:3021 N17.9 D058186 HP:0001919 MicroRNA-21 in the pathogenesis of acute kidney injury. other hsa-mir-125b Acute Lung Injury 25004393 S27 D055371 Enforced expression of miR-125b attenuates LPS-induced acute lung injury. other hsa-mir-16 Acute Lung Injury 29484411 S27 D055371 miR-16 inhibits hyperoxia-induced cell apoptosis in human alveolar epithelial cells other hsa-mir-125b-2 Acute Megakaryoblastic Leukemia 20194440 disease of cellular proliferation DOID:8761 C94.2 D007947 606078 we propose miR-125b-2 as a positive regulator of megakaryopoiesis and an oncomiR involved in the pathogenesis of trisomy 21-associated megakaryoblastic leukemia. other hsa-mir-1291 Acute Myocardial Infarction 24885383 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study. other hsa-mir-133 Acute Myocardial Infarction 24885383 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study. other hsa-mir-133 Acute Myocardial Infarction 29845217 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c. other hsa-mir-134 Acute Myocardial Infarction 24833470 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Predictive value of circulating miR-328 and miR-134 for acute myocardial infarction. other hsa-mir-145 Acute Myocardial Infarction 25465803 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction. other hsa-mir-150 Acute Myocardial Infarction 26077801 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Results indicated that the levels of circulating miR-486 and miR-150 are associated with AMI. They may be novel and powerful biomarkers for AMI,especially for NSTEMI. other hsa-mir-191 Acute Myocardial Infarction 26044724 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction. other hsa-mir-208b Acute Myocardial Infarction 26044724 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction. other hsa-mir-208b Acute Myocardial Infarction 26712201 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 none other hsa-mir-21 Acute Myocardial Infarction 29845217 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c. other hsa-mir-26a Acute Myocardial Infarction 26044724 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction. other hsa-mir-29 Acute Myocardial Infarction 29845217 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c. other hsa-mir-30c Acute Myocardial Infarction 29845217 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c. other hsa-mir-328 Acute Myocardial Infarction 24833470 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Predictive value of circulating miR-328 and miR-134 for acute myocardial infarction. other hsa-mir-486 Acute Myocardial Infarction 26077801 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Results indicated that the levels of circulating miR-486 and miR-150 are associated with AMI. They may be novel and powerful biomarkers for AMI,especially for NSTEMI. other hsa-mir-497 Acute Myocardial Infarction 25110754 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 High association between human circulating microRNA-497 and acute myocardial infarction. other hsa-mir-499 Acute Myocardial Infarction 23872321 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 We developed a novel reverse-transcription real-time PCR assay for human miR-499 quantification. The good reproducibility and wide linearity range may permit more use of it in the quantification of other human miRNAs in future. other hsa-mir-499 Acute Myocardial Infarction 23192357 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 The target miRNA is miRNA-499, a biomarker candidate of AMI with low abundance in biological samples. other hsa-mir-663b Acute Myocardial Infarction 24885383 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study. other hsa-mir-92a Acute Myocardial Infarction 25240056 cardiovascular system disease DOID:9408 I21 D056989 608446 HP:0001658 Early single intracoronary administration of encapsulated antagomir-92a in an adult pig model of reperfused AMI prevents left ventricular remodeling with no local or distant adverse effects other hsa-mir-216 Acute Pancreatitis 28183420 endocrine system disease DOID:2913 K85 D019283 167800 HP:0001735 Circulating microRNA 216 as a Marker for the Early Identification of Severe Acute Pancreatitis. other hsa-mir-216a Acute Pancreatitis 23995054 endocrine system disease DOID:2913 K85 D019283 167800 HP:0001735 MiR-216a and miR-216b as markers for acute phased pancreatic injury. other hsa-mir-216b Acute Pancreatitis 23995054 endocrine system disease DOID:2913 K85 D019283 167800 HP:0001735 MiR-216a and miR-216b as markers for acute phased pancreatic injury. other hsa-mir-34a Acute Pancreatitis 28592850 endocrine system disease DOID:2913 K85 D019283 167800 HP:0001735 NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling. other hsa-mir-27a Adenocarcinoma, Cervical 29531222 disease of cellular proliferation DOID:3702 miR-27a inhibits cervical adenocarcinoma progression by downregulating the TGF-βRI signaling pathway. other hsa-mir-9 Adenocarcinoma, Cervical 25809226 disease of cellular proliferation DOID:3702 our results here present a tumor suppressor potential of miR-9 in cervical adenocarcinoma for the first time and suggest that miR-9 could repress tumorigenesis through inhibiting the activity of IL-6/Jak/STAT3 pathway.has-miR-146b-5p other hsa-mir-193a Adenocarcinoma, Colon 21670079 disease of cellular proliferation DOID:234 C18 HP:0040276 Finally, expression of miR-193a is inversely correlated with PLAU and K-Ras in human colon adenocarcinomas. other hsa-mir-194 Adenocarcinoma, Colon 24691499 disease of cellular proliferation DOID:234 C18 HP:0040276 miR-194 as a predictor for adenoma recurrence in patients with advanced colorectal adenoma after polypectomy. other hsa-mir-21 Adenocarcinoma, Colon 19737943 disease of cellular proliferation DOID:234 C18 HP:0040276 predictors of prognosis other hsa-mir-30 Adenocarcinoma, Colon 27261459 disease of cellular proliferation DOID:234 C18 HP:0040276 miR-30 family likely plays an important role in IEC homeostasis other hsa-mir-96 Adenocarcinoma, Colon 28742206 disease of cellular proliferation DOID:234 C18 HP:0040276 Bioinformatics analysis of RNA-seq data revealed critical genes in colon adenocarcinoma other hsa-mir-34b Adenocarcinoma, Endometrial 22052540 reproductive system disease DOID:2870 C54.1 D018269 608089 HP:0012114 MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma. other hsa-mir-126 Adenocarcinoma, Esophageal 20309880 disease of cellular proliferation DOID:4914 C562730 133239 we found that miR-126 expression was associated with tumor cell de-differentiation and lymph node metastasis, other hsa-mir-145 Adenocarcinoma, Esophageal 25551563 disease of cellular proliferation DOID:4914 C562730 133239 While expression of miR-145 in ESCC stopped proliferation and invasion, expression of miR-145 in EAC cells enhanced invasion and anoikis resistance. Although more work is required to understand how miR-145 conveys these effects, expression of miR-145 appears to promote EAC progression by enhancing invasion and protection against anoikis, which could in turn facilitate distant metastasis. other hsa-mir-16-2 Adenocarcinoma, Esophageal 20309880 disease of cellular proliferation DOID:4914 C562730 133239 miR-16-2 was associated with lymph node metastasis other hsa-mir-195 Adenocarcinoma, Esophageal 20309880 disease of cellular proliferation DOID:4914 C562730 133239 miR-195p was associated with higher pathologic disease stages in patients with esophageal adenocarcinoma other hsa-mir-330 Adenocarcinoma, Esophageal 26221725 disease of cellular proliferation DOID:4914 C562730 133239 MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma. other hsa-mir-143 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-145 Adenocarcinoma, Gastric 25904219 disease of cellular proliferation DOID:3717 D37.1 D013274 Downregulation of the Genes Involved in Reprogramming (SOX2, c-MYC, miR-302,miR-145, and P21) in Gastric Adenocarcinoma. other hsa-mir-155 Adenocarcinoma, Gastric 20209161 disease of cellular proliferation DOID:3717 D37.1 D013274 Taken together, our study describes, in the context of an H. pylori infection, a direct link between Foxp3 and miR-155 in human T cells and highlights the significance of cAMP in this miR-155 induction cascade. other hsa-mir-203 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-205 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-21 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-223 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-23a Adenocarcinoma, Gastric 23688986 disease of cellular proliferation DOID:3717 D37.1 D013274 Suppression of miR-23a with ASO-23a obviously inhibited cell growth, colony formation and invasiveness of MGC803 cells and significantly enhanced the cell apoptosis. other hsa-mir-302 Adenocarcinoma, Gastric 25904219 disease of cellular proliferation DOID:3717 D37.1 D013274 Downregulation of the Genes Involved in Reprogramming (SOX2, c-MYC, miR-302,miR-145, and P21) in Gastric Adenocarcinoma. other hsa-mir-320 Adenocarcinoma, Gastric 24136787 disease of cellular proliferation DOID:3717 D37.1 D013274 Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. other hsa-mir-34a Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-486 Adenocarcinoma, Gastric 25793394 disease of cellular proliferation DOID:3717 D37.1 D013274 Expression and prognostic value of miR-486-5p in patients with gastric adenocarcinoma. other hsa-mir-93 Adenocarcinoma, Gastric 23898078 disease of cellular proliferation DOID:3717 D37.1 D013274 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. other hsa-mir-34 Adenocarcinoma, Lung 28512015 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma. other hsa-let-7c Adenocarcinoma, Lung 23562878 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Ectopic let-7c expression increased the in vitro and in vivo chemo- or radiosensitivity of DTX-resistant LAD cells through enhanced apoptosis, reversal of epithelial-to-mesenchymal phenotypes, and inhibition of in vivo metastatic potential via inactivation of Akt phosphorylation, whereas a let-7c inhibitor decreased the chemo- or radiosensitivity of parental cells other hsa-mir-127 Adenocarcinoma, Lung 24317514 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. other hsa-mir-138 Adenocarcinoma, Lung 26631041 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 we discovered that 伪-solanine could affect the expression of miR-138 and focal adhesion kinase other hsa-mir-140 Adenocarcinoma, Lung 28005074 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MiR-206 and miR-140 also suppressed lung adenocarcinoma cell metastasis in vitro and in vivo by regulating EMT-related factors other hsa-mir-145 Adenocarcinoma, Lung 24026105 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 miR-145 may have a cell type-specific function and play important roles in the process of BM from lung adenocarcinoma. other hsa-mir-145 Adenocarcinoma, Lung 28535533 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MALAT1 Modulates TGF-β1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145. other hsa-mir-146a Adenocarcinoma, Lung 26902276 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Effects of microRNA-146a on Fas-associated factor 2 and inflammatory factors in human lung adenocarcinoma A549 cells under the stimulation of cigarette smoke extract. other hsa-mir-146a Adenocarcinoma, Lung 28299977 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. other hsa-mir-150 Adenocarcinoma, Lung 28299977 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. other hsa-mir-155 Adenocarcinoma, Lung 26899325 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Role of miR-155 in invasion and metastasis of lung adenocarcinoma A549 cells. other hsa-mir-155 Adenocarcinoma, Lung 27081085 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 We identified a regulatory network including miR-15b and miR-155, and transcription factors with prognostic value in lung cancer. other hsa-mir-17 Adenocarcinoma, Lung 23036707 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture other hsa-mir-17 Adenocarcinoma, Lung 26402252 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Identification of Biomarker and Co-Regulatory Motifs in Lung Adenocarcinoma Based on Differential Interactions. other hsa-mir-181b Adenocarcinoma, Lung 29324442 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 ZEB1 initiates a miR-181b-regulated ceRNA network to drive metastasis other hsa-mir-181b Adenocarcinoma, Lung 29434967 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b other hsa-mir-183 Adenocarcinoma, Lung 28115792 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma. other hsa-mir-200a Adenocarcinoma, Lung 23036707 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture other hsa-mir-200b Adenocarcinoma, Lung 26416454 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 These results provide new evidence for the mechanisms governing the microRNA (miRNA)-ATG12 network and their possible contribution to autophagy modulation and LAD chemoresistance. other hsa-mir-200b Adenocarcinoma, Lung 27027446 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 the double-negative feedback loop between E2F3b and miR-200b regulates docetaxel chemosensitivity of human LAD cells other hsa-mir-205 Adenocarcinoma, Lung 23043084 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens. other hsa-mir-205 Adenocarcinoma, Lung 26068980 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Surprisingly, expression of classifier miR-205 was intermediate between that of classical adenocarcinoma and squamous cell carcinoma suggesting that adenosquamous carcinoma is a transitional stage between these tumor types. other hsa-mir-206 Adenocarcinoma, Lung 28005074 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MiR-206 and miR-140 also suppressed lung adenocarcinoma cell metastasis in vitro and in vivo by regulating EMT-related factors other hsa-mir-21 Adenocarcinoma, Lung 28089356 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. other hsa-mir-21 Adenocarcinoma, Lung 23036707 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture other hsa-mir-21 Adenocarcinoma, Lung 29730429 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis. other hsa-mir-210 Adenocarcinoma, Lung 25263437 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. other hsa-mir-214 Adenocarcinoma, Lung 26462018 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Collectively, this study uncovers a previously unappreciated miR-214-Sufu pathway in controlling EMT and metastasis of LAD and suggests that interfering with miR-214 and Sufu could be a viable approach to treat late stage metastatic LAD patients. other hsa-mir-214 Adenocarcinoma, Lung 29288987 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Machine Learning Based Prediction of Brain Metastasis of Patients with IIIA-N2 Lung Adenocarcinoma by a Three-miRNA Signature other hsa-mir-23a Adenocarcinoma, Lung 27492069 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 In addition, miR-23a was significantly enriched in the exosomes after mesenchymal transition. other hsa-mir-24 Adenocarcinoma, Lung 29434967 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b other hsa-mir-25 Adenocarcinoma, Lung 28101226 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Evaluation of plasma microRNA levels to predict insensitivity of patients with advanced lung adenocarcinomas to pemetrexed and platinum. other hsa-mir-29a Adenocarcinoma, Lung 27569280 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-α receptor. other hsa-mir-31 Adenocarcinoma, Lung 29367106 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 down-regulation of MIR31HG had no effect on the expression of miR-31 in lung adenocarcinoma cells other hsa-mir-326 Adenocarcinoma, Lung 27460077 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Overexpression of miR-326 reversed cisplatin chemoresistance of LAD cells in vitro and in vivo. other hsa-mir-342 Adenocarcinoma, Lung 28299977 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. other hsa-mir-34a Adenocarcinoma, Lung 23043084 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens. other hsa-mir-373 Adenocarcinoma, Lung 26182868 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells other hsa-mir-375 Adenocarcinoma, Lung 28533502 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 miR-375 is essential for the progression of LUAD other hsa-mir-376a Adenocarcinoma, Lung 24317514 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. other hsa-mir-451 Adenocarcinoma, Lung 25026294 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Acquisition of radioresistance in docetaxel-resistant human lung adenocarcinoma cells is linked with dysregulation of miR-451/c-Myc-survivin/rad-51 signaling. other hsa-mir-494 Adenocarcinoma, Lung 27575252 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Discriminating between Terminal- and Non-Terminal Respiratory Unit-Type Lung Adenocarcinoma Based on MicroRNA Profiles. other hsa-mir-497 Adenocarcinoma, Lung 28057758 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. other hsa-mir-511 Adenocarcinoma, Lung 24402374 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX. other hsa-mir-551b Adenocarcinoma, Lung 27575252 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Discriminating between Terminal- and Non-Terminal Respiratory Unit-Type Lung Adenocarcinoma Based on MicroRNA Profiles. other hsa-mir-552 Adenocarcinoma, Lung 24778034 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases. other hsa-mir-592 Adenocarcinoma, Lung 24778034 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases. other hsa-mir-608 Adenocarcinoma, Lung 24339958 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Bcl-xL silencing induces alterations in hsa-miR-608 expression and subsequent cell death in A549 and SK-LU1 human lung adenocarcinoma cells. other hsa-mir-9 Adenocarcinoma, Lung 29492899 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 differences in cell response (both miR-9 and proliferation) to dexamethasone in naïve and desialylated cells may point to non-genomic dexamethasone effects other hsa-mir-99a Adenocarcinoma, Lung 23893385 disease of cellular proliferation DOID:3910 C78.00 C538231 211980 HP:0030078 Clinic significance of microRNA-99a expression in human lung adenocarcinoma. other hsa-mir-141 Adenocarcinoma, Pancreatic Ductal 24242138 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinoma. other hsa-mir-145 Adenocarcinoma, Pancreatic Ductal 29137251 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration. other hsa-mir-155 Adenocarcinoma, Pancreatic Ductal 25520858 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 MiR-21, miR-155 and miR-216 in stool have the potential of becoming biomarkers for screening PDAC. other hsa-mir-155 Adenocarcinoma, Pancreatic Ductal 28198398 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma. other hsa-mir-181b Adenocarcinoma, Pancreatic Ductal 28064436 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 MicroRNA-181b-5p, ETS1, and the c-Met pathway exacerbate the prognosis of pancreatic ductal adenocarcinoma after radiation therapy. other hsa-mir-186 Adenocarcinoma, Pancreatic Ductal 25742499 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells. other hsa-mir-194 Adenocarcinoma, Pancreatic Ductal 24398877 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma. other hsa-mir-21 Adenocarcinoma, Pancreatic Ductal 20460539 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 miR-21:miR-21 expression correlated with outcome in PDAC patients treated with gemcitabine other hsa-mir-21 Adenocarcinoma, Pancreatic Ductal 25061297 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. other hsa-mir-21 Adenocarcinoma, Pancreatic Ductal 20093556 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 Our findings indicate that miR-21 warrants further investigation as a marker for early detection of PDAC. other hsa-mir-221 Adenocarcinoma, Pancreatic Ductal 25061297 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. other hsa-mir-222 Adenocarcinoma, Pancreatic Ductal 25061297 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. other hsa-mir-31 Adenocarcinoma, Pancreatic Ductal 29486633 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 The AT-rich interactive domain 1A expression level in the cells was increased following microRNA-31 (miR-31) inhibitor transfection other hsa-mir-326 Adenocarcinoma, Pancreatic Ductal 25742499 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells. other hsa-mir-34a Adenocarcinoma, Pancreatic Ductal 27594424 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma. other hsa-mir-375 Adenocarcinoma, Pancreatic Ductal 27862697 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma. other hsa-mir-375 Adenocarcinoma, Pancreatic Ductal 28122349 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. other hsa-mir-663 Adenocarcinoma, Pancreatic Ductal 26028359 disease of cellular proliferation DOID:3498 C25.3 D021441 260350 MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression. other hsa-mir-126 Adenocarcinoma, Prostate 28089917 disease of cellular proliferation DOID:2526 C61 D011471 176807 microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma. other hsa-mir-141 Adenocarcinoma, Prostate 25252191 disease of cellular proliferation DOID:2526 C61 D011471 176807 Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery. other hsa-mir-154 Adenocarcinoma, Prostate 28089917 disease of cellular proliferation DOID:2526 C61 D011471 176807 microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma. other hsa-mir-21 Adenocarcinoma, Prostate 25252191 disease of cellular proliferation DOID:2526 C61 D011471 176807 Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery. other hsa-mir-21 Adenocarcinoma, Prostate 28089917 disease of cellular proliferation DOID:2526 C61 D011471 176807 microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma. other hsa-mir-221 Adenocarcinoma, Prostate 25252191 disease of cellular proliferation DOID:2526 C61 D011471 176807 Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery. other hsa-mir-372 Adenocarcinoma, Prostate 26662140 disease of cellular proliferation DOID:2526 C61 D011471 176807 hsa-miR-372 and miR-373, we suggest that miR-ch21 down-regulation might be the result of specific silencing of miR genes mapped to chromosome 21 other hsa-mir-148a Adenovirus Infection 25714032 B34.0 D000257 Thus, miRNA-control of late proteins constitutes a novel strategy to provide selectivity to adenoviruses. other hsa-mir-155 Adenovirus Infection 27916071 B34.0 D000257 The effect of curcumin on the expression of miR-155 to apoptosis and invasion of extravillus trophoblast cells treated by lipopolysaccharide. other hsa-mir-26b Adenovirus Infection 28114818 B34.0 D000257 Functional Screening Identifies Human miRNAs that Modulate Adenovirus Propagation in Prostate Cancer Cells. other hsa-mir-30c Adenovirus Infection 24239602 B34.0 D000257 Comparison of RNAi with CCN2-modulating microRNA (miR) vectors expressing miR-30c or miR-133b showed higher efficacy of RNAi. other hsa-mir-100 Adrenal Cortex Neoplasms 20484036 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 miR-100:differentially regulated in childhood adrenocortical tumors (ACT), including miR-99a and miR-100 other hsa-mir-142 Adrenal Cortex Neoplasms 28110695 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors other hsa-mir-24 Adrenal Cortex Neoplasms 28110695 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors other hsa-mir-99a Adrenal Cortex Neoplasms 20484036 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 miR-99a:differentially regulated in childhood adrenocortical tumors (ACT), including miR-99a and miR-100 other hsa-mir-130a Adrenal Cortex Neoplasms 19849700 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 miR-130a:miR-130a and miR-382 as putative diagnostic MMAD markers other hsa-mir-382 Adrenal Cortex Neoplasms 19849700 disease of cellular proliferation DOID:0050891 C74.0 D000306 HP:0100641 miR-382:miR-130a and miR-382 as putative diagnostic MMAD markers other hsa-mir-150 Age-Related Macular Degeneration 29618664 nervous system disease DOID:10871 H35.30 D008268 PS603075 miR-150 as pathogenic in AMD and provide potentially novel molecular insights into diseases of aging other hsa-mir-184 Age-Related Macular Degeneration 29325388 nervous system disease DOID:10871 H35.30 D008268 PS603075 miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract other hsa-mir-34a Alcoholic Hepatitis 26403328 endocrine system disease DOID:12351 K70.1 D006519 These results constitute a demonstration of the altered regulation of miR-34a and miR-483-3p in the livers of AH and mice fed DDC where MDBs formed, providing further insight into the mechanism of MDB formation mediated by miR-34a and miR-483-3p in AH. other hsa-mir-483 Alcoholic Hepatitis 26403328 endocrine system disease DOID:12351 K70.1 D006519 These results constitute a demonstration of the altered regulation of miR-34a and miR-483-3p in the livers of AH and mice fed DDC where MDBs formed, providing further insight into the mechanism of MDB formation mediated by miR-34a and miR-483-3p in AH. other hsa-mir-144 Allergic Asthma 26646558 immune system disease DOID:9415 J45.909 C564133 600807 Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease. other hsa-mir-155 Allergic Asthma 29104649 immune system disease DOID:9415 J45.909 C564133 600807 Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma. other hsa-mir-34a Allergic Asthma 26646558 immune system disease DOID:9415 J45.909 C564133 600807 Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease. other hsa-mir-34b Allergic Asthma 26646558 immune system disease DOID:9415 J45.909 C564133 600807 Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease. other hsa-mir-155 Allergic Contact Dermatitis 29404871 immune system disease DOID:3042 L23 D017449 Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells other hsa-mir-21 Allergic Contact Dermatitis 29282578 immune system disease DOID:3042 L23 D017449 MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway other hsa-mir-17 Allergic Rhinitis 27491928 respiratory system disease DOID:4481 J30.9 D065631 607154 HP:0003193 The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants. other hsa-mir-18a Allergic Rhinitis 27491928 respiratory system disease DOID:4481 J30.9 D065631 607154 HP:0003193 The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants. other hsa-mir-19b Allergic Rhinitis 27491928 respiratory system disease DOID:4481 J30.9 D065631 607154 HP:0003193 circulation_biomarker_diagnosis_up other hsa-mir-20a Allergic Rhinitis 27491928 respiratory system disease DOID:4481 J30.9 D065631 607154 HP:0003193 The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants. other hsa-mir-92a Allergic Rhinitis 27491928 respiratory system disease DOID:4481 J30.9 D065631 607154 HP:0003193 The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants. other hsa-mir-126 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-155 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-17 Allergy 29122948 immune system disease DOID:1205 T78.40 D006967 HP:0012393 MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. other hsa-mir-21 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-210 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-22 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-27b Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-31 Allergy 24063594 immune system disease DOID:1205 T78.40 D006967 HP:0012393 Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. other hsa-mir-106b Alopecia 19821055 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 mir-106b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB other hsa-mir-125b-1 Alopecia 19821055 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 miR-125b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB other hsa-mir-125b-2 Alopecia 19821055 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 miR-125b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB other hsa-mir-203 Alopecia 25939713 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 RBM28 contributes to HF growth regulation through modulation of miR-203 and p63 activity. other hsa-mir-221 Alopecia 19821055 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 miR-221:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB other hsa-mir-410 Alopecia 19821055 integumentary system disease DOID:987 L65.9 D000505 300042 HP:0001596 miR-410:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB other hsa-mir-221 Alveolar Rhabdomyosarcoma 29367756 disease of cellular proliferation DOID:4051 D018232 268220 HP:0006779 PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. other hsa-mir-29 Alveolar Rhabdomyosarcoma 28883017 disease of cellular proliferation DOID:4051 D018232 268220 HP:0006779 the NFκB-YY1-miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor suppressor activity other hsa-mir-486 Alveolar Rhabdomyosarcoma 29367756 disease of cellular proliferation DOID:4051 D018232 268220 HP:0006779 PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. other hsa-let-7a Alzheimer Disease 25759134 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-let-7b Alzheimer Disease 29170128 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 let-7b has an important association with the pathology of AD and can be used as an adjunct to improve the diagnostic performance of traditional AD biomarkers other hsa-mir-101 Alzheimer Disease 24194717 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network. other hsa-mir-101-1 Alzheimer Disease 21172309 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed. other hsa-mir-106b Alzheimer Disease 19110058 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-106b: endogenous regulators of APP expression other hsa-mir-106b Alzheimer Disease 24194717 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network. other hsa-mir-107 Alzheimer Disease 20413881 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. other hsa-mir-107 Alzheimer Disease 27143098 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 osthole plays a neuroprotective activity role in part through up-regulate miR-107 in AD. other hsa-mir-10a Alzheimer Disease 29215712 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-10a restrains synapse remodeling and neuronal cell proliferation while promoting apoptosis in AD rats via inhibiting BDNF-TrkB signaling pathway other hsa-mir-124 Alzheimer Disease 28912710 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Aβ downregulated miR-155 and miR-124, and reduced the CD11b+ subpopulation in 2 DIV microglia other hsa-mir-125b Alzheimer Disease 24293102 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells. other hsa-mir-125b Alzheimer Disease 25001178 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. other hsa-mir-125b Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-132 Alzheimer Disease 26792551 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. other hsa-mir-132 Alzheimer Disease 28148775 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. other hsa-mir-146a Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-146a Alzheimer Disease 27797173 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. other hsa-mir-146a Alzheimer Disease 29615954 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer's Disease other hsa-mir-148b Alzheimer Disease 24352679 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. other hsa-mir-155 Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-155 Alzheimer Disease 28912710 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Aβ downregulated miR-155 and miR-124, and reduced the CD11b+ subpopulation in 2 DIV microglia other hsa-mir-15a Alzheimer Disease 24352679 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. other hsa-mir-15b Alzheimer Disease 29207665 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-15b play an important role in the cellular AD phenotype and might be involved in the pathogenesis of AD other hsa-mir-17 Alzheimer Disease 19110058 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-17-5p: endogenous regulators of APP expression other hsa-mir-17 Alzheimer Disease 24194717 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network. other hsa-mir-186 Alzheimer Disease 27029568 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-186 in Alzheimer's disease: a big hope for a small RNA other hsa-mir-195 Alzheimer Disease 27693395 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice. other hsa-mir-200c Alzheimer Disease 25759134 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-20a Alzheimer Disease 19110058 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-20a: endogenous regulators of APP expression other hsa-mir-20a Alzheimer Disease 24194717 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network. other hsa-mir-20a Alzheimer Disease 24423585 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 The results of microarray analysis showed that miR-329, miR-193b, miR-20a, miR-296, and miR-130b were all upregulated in H2O2-induced primary hippocampal neurons and different strains of senescence accelerated mice. other hsa-mir-21 Alzheimer Disease 29635890 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-21 can exert protective roles in AD, which might be dependent on PDCD4/PI3K/AKT/GSK-3β signaling pathway in vitro other hsa-mir-27a Alzheimer Disease 24212398 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Our pilot study highlights hsa-miR-27a-3p as a candidate biomarker for AD and provides the groundwork for further confirmation studies in larger cohorts and in other hospitals. other hsa-mir-323 Alzheimer Disease 24283221 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy. other hsa-mir-33 Alzheimer Disease 26936997 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Understanding the Role of miR-33 in Brain Lipid Metabolism: Implications for Alzheimer's Disease. other hsa-mir-342 Alzheimer Disease 24440716 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. other hsa-mir-34a Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-34a Alzheimer Disease 27378912 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Over-Expressed Pathogenic miRNAs in Alzheimer's Disease (AD) and Prion Disease (PrD) Drive Deficits in TREM2-Mediated Aβ42 Peptide Clearance. other hsa-mir-34a Alzheimer Disease 28652929 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 TNF-α and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-α-Induced Neurotoxicity. other hsa-mir-532 Alzheimer Disease 26402772 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Although we could not consistently separate AD patients and controls in the whole group, we have found indications miRNA in CSF are able to reflect aging and perhaps also heterogeneity in AD. Further investigation requires optimizing RNA input, while maintaining strict age matching. other hsa-mir-663 Alzheimer Disease 25695604 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 Our results indicate that AICD has a novel role in suppression of neuronal differentiation via transcriptional regulation of miR-663 in human neural stem cells. other hsa-mir-7 Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-7 Alzheimer Disease 28296235 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 the circular RNA circular RNA sponge for miR-7 (ciRS-7) has an important role in regulating BACE1 and APP protein levels other hsa-mir-9 Alzheimer Disease 26694372 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. other hsa-mir-9 Alzheimer Disease 27394443 nervous system disease DOID:10652 G30.9 D000544 104300 HP:0002511 These results demonstrated that osthole plays a neuroprotective activity role in part through upregulating miR-9 in AD. other hsa-mir-125b Amyotrophic Lateral Sclerosis 28090150 nervous system disease DOID:332 G12.21 D000690 PS105400 HP:0007354 M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. other hsa-mir-146a Amyotrophic Lateral Sclerosis 28612258 nervous system disease DOID:332 G12.21 D000690 PS105400 HP:0007354 Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage. other hsa-mir-155 Amyotrophic Lateral Sclerosis 28612258 nervous system disease DOID:332 G12.21 D000690 PS105400 HP:0007354 Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage. other hsa-mir-206 Amyotrophic Lateral Sclerosis 20007902 nervous system disease DOID:332 G12.21 D000690 PS105400 HP:0007354 MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice other hsa-mir-125a Androgenetic Alopecia 25778683 integumentary system disease DOID:0050801 L64.9 D000505 109200 These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS. other hsa-mir-485 Androgenetic Alopecia 25778683 integumentary system disease DOID:0050801 L64.9 D000505 109200 These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS. other hsa-mir-7 Androgenetic Alopecia 25778683 integumentary system disease DOID:0050801 L64.9 D000505 109200 These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS. other hsa-mir-144 Anemia 29269522 hematopoietic system disease DOID:2355 D64.9 D000740 300751 miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia other hsa-mir-151a Anemia 21921042 hematopoietic system disease DOID:2355 D64.9 D000740 300751 Expression of miR-26b and miR-151-3p were both associated with HbF levels at MTD (maximum tolerated dose). other hsa-mir-26b Anemia 21921042 hematopoietic system disease DOID:2355 D64.9 D000740 300751 Expression of miR-26b and miR-151-3p were both associated with HbF levels at MTD (maximum tolerated dose). other hsa-mir-34a Anemia 23222379 hematopoietic system disease DOID:2355 D64.9 D000740 300751 Thus, in FA patients, increased apoptosis occurs in target epithelial cells of severe aGVHD, and this deleterious effect is linked to overexpression of miR-34a but not TP53. other hsa-mir-194 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-19b-1 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-21 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-362 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-550 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-769 Aneurysm 26771601 I72.9 D000783 105800 Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. other hsa-mir-155 Ankylosing Spondylitis 27412942 musculoskeletal system disease DOID:7147 M45.9 D013167 Conclusion XFC could effectively improve hypercoagulative state in active AS patients. The potential mechanism may be associated with the inhibition of miR-155 and NF-魏B signal pathway. other hsa-mir-19b-1 Antiphospholipid Syndrome 21794077 immune system disease DOID:2988 D68.61 D016736 107320 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. other hsa-mir-20a Antiphospholipid Syndrome 21794077 immune system disease DOID:2988 D68.61 D016736 107320 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. other hsa-mir-15b Anus Neoplasm 22045185 disease of cellular proliferation DOID:4551 C21.0 D001005 The expression of miR-15b was shown to be highly correlated with that of five selected E2F-induced genes (CCNA2, CCNB1, CCNB2, MSH6 and MCM7). A knockdown of HPV16 E7 resulted in decreased levels of miR-15b in Ca Ski cells.Conclusion:MiR-15b expression correlates with E2F-regulated genes in anal carcinoma and appears to be part of the E2F-regulatory network. other hsa-mir-143 Aortic Aneurysm 28167124 cardiovascular system disease DOID:3627 I71 D001014 100070 HP:0004942 P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. other hsa-mir-145 Aortic Aneurysm 28167124 cardiovascular system disease DOID:3627 I71 D001014 100070 HP:0004942 P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. other hsa-mir-195 Aortic Aneurysm 25201911 cardiovascular system disease DOID:3627 I71 D001014 100070 HP:0004942 We provide the first evidence that miR-195 may contribute to the pathogenesis of aortic aneurysmal disease. Although inhibition of miR-29b proved more effective in preventing aneurysm formation in a preclinical model, miR-195represents a potent regulator of the aortic extracellular matrix. Notably, plasma levels of miR-195 were reduced in patients with abdominal aortic aneurysms suggesting that microRNAs might serve as a noninvasive biomarker of abdominal aortic aneurysms. other hsa-mir-29b Aortic Aneurysm 25342766 cardiovascular system disease DOID:3627 I71 D001014 100070 HP:0004942 Battle of the bulge: miR-195 versus miR-29b in aortic aneurysm. other hsa-mir-145 Aortic Aneurysm, Abdominal 27956160 cardiovascular system disease DOID:7693 I71.3-.4 D017544 PS100070 MicroRNA-145 Mediates the Formation of Angiotensin II-Induced Murine Abdominal Aortic Aneurysm. other hsa-mir-155 Aortic Aneurysm, Abdominal 24283299 cardiovascular system disease DOID:7693 I71.3-.4 D017544 PS100070 microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155. other hsa-mir-181b Aortic Aneurysm, Abdominal 27756793 cardiovascular system disease DOID:7693 I71.3-.4 D017544 PS100070 MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. other hsa-mir-21 Aortic Aneurysm, Abdominal 22357537 cardiovascular system disease DOID:7693 I71.3-.4 D017544 PS100070 MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. other hsa-mir-29b Aortic Aneurysm, Abdominal 23871588 cardiovascular system disease DOID:7693 I71.3-.4 D017544 PS100070 MicroRNA-29b regulation of abdominal aortic aneurysm development. other hsa-mir-125b Aortic Insufficiency 26203686 cardiovascular system disease DOID:57 I35.1 D001022 HP:0001659 MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease. other hsa-mir-22 Aortic Stenosis 26304936 cardiovascular system disease DOID:1712 I35.0 D001024 109730 HP:0001650 Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis. other hsa-mir-24 Aortic Stenosis 26304936 cardiovascular system disease DOID:1712 I35.0 D001024 109730 HP:0001650 Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis. other hsa-mir-378 Aortic Stenosis 25157568 cardiovascular system disease DOID:1712 I35.0 D001024 109730 HP:0001650 Circulating levels of miR-1, miR-133 and miR-378 were decreased in AS patients, and miR-378 predicts LVH independent of the pressure gradient. Further prospective investigations are needed to elucidate whether these circulating miRs affect clinical outcome. other hsa-mir-382 Aortic Stenosis 26304936 cardiovascular system disease DOID:1712 I35.0 D001024 109730 HP:0001650 Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis. other hsa-mir-451a Aortic Stenosis 26304936 cardiovascular system disease DOID:1712 I35.0 D001024 109730 HP:0001650 Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis. other hsa-mir-126 Aplastic Anemia 26354756 hematopoietic system disease DOID:12449 D61.9 D000741 609135 HP:0001915 Identification of novel microRNA signatures linked to acquired aplastic anemia. other hsa-mir-145 Aplastic Anemia 26354756 hematopoietic system disease DOID:12449 D61.9 D000741 609135 HP:0001915 Identification of novel microRNA signatures linked to acquired aplastic anemia. other hsa-mir-199a Aplastic Anemia 26354756 hematopoietic system disease DOID:12449 D61.9 D000741 609135 HP:0001915 Identification of novel microRNA signatures linked to acquired aplastic anemia. other hsa-mir-223 Aplastic Anemia 26354756 hematopoietic system disease DOID:12449 D61.9 D000741 609135 HP:0001915 Identification of novel microRNA signatures linked to acquired aplastic anemia. other hsa-mir-1 Arrhythmia 24468403 I49.9 D001145 600919 HP:0011675 Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). other hsa-mir-1-1 Arrhythmia 17401374 I49.9 D001145 600919 HP:0011675 These data strongly indicate that miR-1 is an arrhythmogenic or proarrhythmic factor that is detrimental to the ischemic heart. Delivery of miR-1 into healthy hearts was also arrhythmogenic. other hsa-mir-1-1 Arrhythmia 17786230 I49.9 D001145 600919 HP:0011675 the finding that increasing or decreasing miR-1 expression causes lethal cardiac arrhythmias highlights not only the exquisite sensitivity of the heart to the levels of expression of this miRNA but also poses significant hurdles to the possible therapeutic manipulation of miR-1 levels in the settings of cardiac conduction abnormalities or myocardial repair. other hsa-mir-1-2 Arrhythmia 17401374 I49.9 D001145 600919 HP:0011675 These data strongly indicate that miR-1 is an arrhythmogenic or proarrhythmic factor that is detrimental to the ischemic heart. Delivery of miR-1 into healthy hearts was also arrhythmogenic. other hsa-mir-1-2 Arrhythmia 17786230 I49.9 D001145 600919 HP:0011675 the finding that increasing or decreasing miR-1 expression causes lethal cardiac arrhythmias highlights not only the exquisite sensitivity of the heart to the levels of expression of this miRNA but also poses significant hurdles to the possible therapeutic manipulation of miR-1 levels in the settings of cardiac conduction abnormalities or myocardial repair. other hsa-mir-133a Arrhythmia 23497314 I49.9 D001145 600919 HP:0011675 Multiple miR-133a isomiRs with potential different mRNA target profiles are present in the atrium in humans and mice. other hsa-mir-133a-1 Arrhythmia 17786230 I49.9 D001145 600919 HP:0011675 These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-goбзCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells. other hsa-mir-133a-2 Arrhythmia 17786230 I49.9 D001145 600919 HP:0011675 These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-goбзCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells. other hsa-mir-126 Arteriosclerosis Obliterans 21969012 cardiovascular system disease DOID:5160 D001162 HP:0002634 Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. other hsa-mir-126 Arteriosclerosis Obliterans 28143713 cardiovascular system disease DOID:5160 D001162 HP:0002634 Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6. other hsa-mir-133a Arteriosclerosis Obliterans 25740337 cardiovascular system disease DOID:5160 D001162 HP:0002634 MicroRNA-133a in the Development of Arteriosclerosis Obliterans. other hsa-mir-133a Arteriosclerosis Obliterans 21969012 cardiovascular system disease DOID:5160 D001162 HP:0002634 Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. other hsa-mir-140 Arteriosclerosis Obliterans 20528768 cardiovascular system disease DOID:5160 D001162 HP:0002634 Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16). other hsa-mir-182 Arteriosclerosis Obliterans 20528768 cardiovascular system disease DOID:5160 D001162 HP:0002634 Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16). other hsa-mir-21 Arteriosclerosis Obliterans 29506703 cardiovascular system disease DOID:5160 D001162 HP:0002634 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction other hsa-mir-499 Arteriosclerosis Obliterans 21969012 cardiovascular system disease DOID:5160 D001162 HP:0002634 Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. other hsa-mir-92a Arteriosclerosis Obliterans 20528768 cardiovascular system disease DOID:5160 D001162 HP:0002634 Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16). other hsa-mir-92b Arteriosclerosis Obliterans 20528768 cardiovascular system disease DOID:5160 D001162 HP:0002634 Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16). other hsa-mir-140 Arthritis 27165343 musculoskeletal system disease DOID:848 M19.90 D001168 estrogen acts via ER and miR-140 to inhibit the catabolic activity of proteases within the chondrocyte extracellular matrix. other hsa-mir-146a Arthritis 28545737 musculoskeletal system disease DOID:848 M19.90 D001168 MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. other hsa-let-7a Asthma 25759134 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-let-7a-1 Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7a-2 Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7a-3 Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7b Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7b:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7c Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7c:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7d Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7d:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7e Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7e:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7f Asthma 26242299 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 17β-E2+P4 increased IL-17A production from TH17 cells, providing a potential mechanism for the increased prevalence of severe asthma in women compared with men. other hsa-let-7f Asthma 29455573 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle other hsa-let-7f-1 Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7f:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7f-2 Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7f:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7g Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7g:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-let-7i Asthma 20630862 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 let-7i:Proinflammatory role for let-7 microRNAS in experimental asthma other hsa-mir-128 Asthma 29231896 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Downregulated miR-128 and miR-744 supports a Th2/Th17 type immune response in severe equine asthma other hsa-mir-133a Asthma 29191361 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 The relative expression of miRNA-133a increased in the low-dose anti-IgE, high-dose anti-IgE, fluticasone+anti-IgE and anti-TNF groups other hsa-mir-146a Asthma 22580216 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone. other hsa-mir-146a Asthma 27463381 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-146b Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-146b Asthma 22580216 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone. other hsa-mir-148b Asthma 25266681 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion. other hsa-mir-152 Asthma 25266681 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion. other hsa-mir-155 Asthma 27463381 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-181a Asthma 22580216 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone. other hsa-mir-19a Asthma 28081849 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling. other hsa-mir-200c Asthma 25759134 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-21 Asthma 27463381 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-21 Asthma 28379062 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inhibition of MicroRNA-21 by an antagomir ameliorates allergic inflammation in a mouse model of asthma. other hsa-mir-221 Asthma 22572970 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inhibition of miRNA-221 Suppresses the Airway Inflammation in Asthma. other hsa-mir-221 Asthma 23944957 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. other hsa-mir-221 Asthma 27113449 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 The degranulation was found to be significantly increased in miR-221 overexpressed cells while it was found to be significantly decreased in miR-221 downregulated cells. other hsa-mir-223 Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-29b Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-29c Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-33b Asthma 28785038 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b. other hsa-mir-34 Asthma 24313771 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA. other hsa-mir-449 Asthma 24313771 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA. other hsa-mir-483 Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-574 Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-672 Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-690 Asthma 21305051 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. other hsa-mir-744 Asthma 29231896 respiratory system disease DOID:2841 J45 D001249 600807 HP:0002099 Downregulated miR-128 and miR-744 supports a Th2/Th17 type immune response in severe equine asthma other hsa-mir-21 Astrocytoma 27504157 disease of cellular proliferation DOID:3069 C72.9 D001254 155755 HP:0009592 Our data showed that in 1321N1 cells, 尾-adrenergic-Epac pathway stimulation up and down-regulated Cx43 and miR-21 expression respectively. other hsa-mir-221 Astrocytoma 26454049 disease of cellular proliferation DOID:3069 C72.9 D001254 155755 HP:0009592 Loss of miR-221 function and cytotoxicity induced by the miR-221 DOXO MB provides combined therapeutic efficacy against cancers. other hsa-mir-335 Astrocytoma 21592405 disease of cellular proliferation DOID:3069 C72.9 D001254 155755 HP:0009592 Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells. other hsa-mir-100 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-10a Atherosclerosis 21952822 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Endothelial inflammation is critically regulated by miRNAs such as miR-126 and miR-10a in vitro and in vivo. other hsa-mir-125b Atherosclerosis 27835742 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis. other hsa-mir-126 Atherosclerosis 19996457 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Administration of apoptotic bodies or miR-126 limited atherosclerosis other hsa-mir-126 Atherosclerosis 23324496 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 whereas the endothelial cell-specific miRNA-126 signals the need for endothelial repair through its transfer from apoptotic endothelial cells in microvesicles other hsa-mir-126 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-126 Atherosclerosis 24870014 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 These effects may explain the ability of pitavastatin to reduce the progression of atherosclerosis. The findings further suggest that inhibitory effect of pitavastatin on VCAM-1 is not related to miR-126 but depends on other ways. other hsa-mir-126 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-126 Atherosclerosis 21952822 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Endothelial inflammation is critically regulated by miRNAs such as miR-126 and miR-10a in vitro and in vivo. other hsa-mir-126 Atherosclerosis 24022569 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Increased miR-146a and miR-126 and reduced miR-155 levels were observed in both treatment groups (all, P<0.001) other hsa-mir-126 Atherosclerosis 24833799 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-126 in atherosclerosis other hsa-mir-126 Atherosclerosis 24933211 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a. other hsa-mir-126 Atherosclerosis 25315114 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNAs (miRNAs) encapsulated within microparticles (MPs) are likely to have a role in cell-to-cell signaling in a variety of diseases, including atherosclerosis. other hsa-mir-126 Atherosclerosis 26001902 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Conversely, CXCL12 expression can be induced by miR-126 in ECs through an auto-amplifying feedback loop to facilitate endothelial regeneration, thus limiting atherosclerosis and mediating plaque stabilization. other hsa-mir-126 Atherosclerosis 26662986 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored. other hsa-mir-126 Atherosclerosis 27748840 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Paeonol promotes microRNA-126 expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-κB pathway. other hsa-mir-126 Atherosclerosis 27870587 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 17β-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis. other hsa-mir-126 Atherosclerosis 27923459 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNAs in lipid metabolism and atherosclerosis. other hsa-mir-126 Atherosclerosis 28678312 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Identification of miRNAs as atherosclerosis biomarkers and functional role of miR-126 in atherosclerosis progression through MAPK signalling pathway. other hsa-mir-126 Atherosclerosis 29203244 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway other hsa-mir-1264 Atherosclerosis 26047583 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 This could be a causative epigenetic mechanism associated with TNF-α and IGF-1 induced smooth muscle cell proliferation involved in the pathogenesis of coronary artery hyperplasia and restenosis. other hsa-mir-127 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-133 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-143 Atherosclerosis 22373869 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Secreted miRNAs (miR-143/145) suppress atherogenesis. other hsa-mir-143 Atherosclerosis 27775792 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 miR-143 is involved in endothelial cell dysfunction through suppression of glycolysis and correlated with atherosclerotic plaques formation. other hsa-mir-145 Atherosclerosis 22373869 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Secreted miRNAs (miR-143/145) suppress atherogenesis. other hsa-mir-145 Atherosclerosis 23324496 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Downregulation of miR-145, which controls differentiation of smooth muscle cells, promotes lesion formation other hsa-mir-145 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-146 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-146 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-146a Atherosclerosis 20195282 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 this study also provided evidence that miR-146a treatment in vitro could induce the protein expression of TNF-alpha, MCP-1, NF-kappaB p65, which are key pro-inflammatory cytokines and critical transcription factor in AS other hsa-mir-146a Atherosclerosis 28637783 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. other hsa-mir-146a Atherosclerosis 28882869 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 EV-derived miRNAs from atherogenic macrophages, in particular miR-146a, may accelerate the development of atherosclerosis by decreasing cell migration and promoting macrophage entrapment in the vessel wall other hsa-mir-146a Atherosclerosis 29449647 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 they express a remarkably high basal level of miR-146a, a microRNA known to negatively regulate the TLR pathway other hsa-mir-150 Atherosclerosis 28254813 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions. other hsa-mir-152 Atherosclerosis 22370758 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Co-expression in plaque tissue and classical monocytes. other hsa-mir-155 Atherosclerosis 23324496 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Elevated miR-155 levels are characteristic of proinflammatory macrophages and atherosclerotic lesions other hsa-mir-155 Atherosclerosis 23513069 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1-and microRNA-155-Dependent Pathway during Atherosclerosis other hsa-mir-155 Atherosclerosis 23827206 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-155 in the pathogenesis of atherosclerosis other hsa-mir-155 Atherosclerosis 24767942 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 We hypothesized that native LDL and oxidized LDL played a key role in modulating the effects of miR-155 on macrophages at different stages of atherosclerosis. other hsa-mir-155 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-155 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-155 Atherosclerosis 28407320 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients. other hsa-mir-155 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-155 Atherosclerosis 24933211 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a. other hsa-mir-155 Atherosclerosis 29465752 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 both the atherosclerosis inducer ox-LDL and atheroprotective factor KLF2 regulated inflammation-associated microRNA-155 (miR-155) expression in human umbilical vein endothelial cells (HUVECs) other hsa-mir-17 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-185 Atherosclerosis 26523989 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 These findings reveal that miR-185 controls cholesterol homeostasis as a key posttranscriptional LDLR modulator in hepatic cells, providing novel insight into the regulatory mechanism for LDLR expression and the anti-atherosclerosis effect of miR-185-inhibitor. other hsa-mir-19b Atherosclerosis 25765596 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The present study demonstrates that Dgn enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. other hsa-mir-20a Atherosclerosis 24933211 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a. other hsa-mir-21 Atherosclerosis 21817107 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities. other hsa-mir-21 Atherosclerosis 25882990 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 In atherosclerosis, miR-21 is increased in the aorta and associated with vitamin D deficiency. Vitamin D deficiency may influence aberrant miR-21 expression in vasculature and bone contributing to the concurrent development of atherosclerosis and osteoporosis. other hsa-mir-21 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-21 Atherosclerosis 24562307 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 In ox-LDL treated VECs, transfection with a miR-21 mimic significantly increased miR-21 expression and inhibited PTEN expression, and attenuated the protective effects of paeonol pretreatment, whereas transfection with an miR-21 inhibitor significantly decreased miR-21 expression and increased PTEN expression, thus enhanced the protective effects of paeonol pretreatment. other hsa-mir-21 Atherosclerosis 25961718 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 resveratrol significantly reduced miR-21 expression other hsa-mir-21 Atherosclerosis 25981603 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 miR-21 is involved in ischemic stroke pathology through atherosclerosis and provides neuroprotection by its anti-apoptotic features. other hsa-mir-21 Atherosclerosis 27107761 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 LaCM decreased apoptosis, necrosis and inflammatory miR-155 and conversely increased anti-apoptotic miR-21 in Ec-LPS-treated HUVECs. other hsa-mir-21 Atherosclerosis 28674080 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. other hsa-mir-21 Atherosclerosis 29503197 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions other hsa-mir-21 Atherosclerosis 29659130 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 its involvement in the complex development of atherosclerosis has yet to be ascertained other hsa-mir-210 Atherosclerosis 25981603 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 miR-497 induces neuronal death and miR-210 is upregulated in hypoxic cells. other hsa-mir-210 Atherosclerosis 27895035 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. other hsa-mir-210 Atherosclerosis 28367268 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210. other hsa-mir-221 Atherosclerosis 26221589 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling. other hsa-mir-221 Atherosclerosis 26451018 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder,suggesting an association between these miRNAs and atherosclerotic plaque stability. other hsa-mir-221 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-221 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-221 Atherosclerosis 27644883 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. other hsa-mir-222 Atherosclerosis 26221589 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling. other hsa-mir-222 Atherosclerosis 26451018 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder,suggesting an association between these miRNAs and atherosclerotic plaque stability. other hsa-mir-222 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-222 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-222 Atherosclerosis 27644883 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. other hsa-mir-223 Atherosclerosis 25463083 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MiR-223-mediated suppression of TF expression provides a novel molecular mechanism for the regulation of coagulation cascade, and suggests a clue against thrombogenesis during the process of atherosclerotic plaque rupture. other hsa-mir-23b Atherosclerosis 22955103 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 In addition, members of the miR-23-27-24 cluster are increased and specifically miR-23b blocks cell cycle progression, whereas miR-27b was shown to reduce endothelial cell repulsive signals. other hsa-mir-24 Atherosclerosis 24815336 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. other hsa-mir-27b Atherosclerosis 22955103 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 In addition, members of the miR-23-27-24 cluster are increased and specifically miR-23b blocks cell cycle progression, whereas miR-27b was shown to reduce endothelial cell repulsive signals. other hsa-mir-29 Atherosclerosis 23774505 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. other hsa-mir-29 Atherosclerosis 26309238 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Transcriptional and posttranscriptional mechanisms contribute to the dysregulation of elastogenesis in Schimke immuno-osseous dysplasia. other hsa-mir-296 Atherosclerosis 20415654 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Tumor angiogenesis is additionally controlled by miR-296 and miR-378. other hsa-mir-29a Atherosclerosis 28593745 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 ox-LDL increases microRNA-29a transcription through upregulating YY1 and STAT1 in macrophages. other hsa-mir-30a Atherosclerosis 26176854 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 we here report the successful use of miRNA technology to silence a platelet protein in megakaryoblastic cells and demonstrate its usefulness in functional assays. Hence, we believe that artificial miRNAs are suitable tools to unravel the role of a protein of interest in stem cells, megakaryocytes and platelets, thereby expanding their application to novel fields of basic and translational research. other hsa-mir-30e Atherosclerosis 28123167 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 miR-30e in VSMCs exerted an anti-atherosclerosis effect via inhibiting proliferation and migration, and promoting apoptosis of VSMCs other hsa-mir-31 Atherosclerosis 21946298 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-33 Atherosclerosis 24086374 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 These results reveal a novel mechanism for the BA-mediated ABCA1 expression, which may provide new insights for developing strategies for modulating vascular inflammation and atherosclerosis. other hsa-mir-33 Atherosclerosis 24953492 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Taken together, these results reveal that C. pneumoniae may negatively regulate ABCA1 expression via TLR2-NF-κB and miR-33 pathways in THP-1 macrophage-derived foam cells, which may provide new insights for understandingthe effects of C. pneumoniae on the pathogenesis of atherosclerosis. other hsa-mir-33 Atherosclerosis 27905947 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions. other hsa-mir-33 Atherosclerosis 27920122 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. other hsa-mir-33 Atherosclerosis 28296196 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. other hsa-mir-33 Atherosclerosis 28428217 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis. other hsa-mir-33a Atherosclerosis 22274626 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. other hsa-mir-33a Atherosclerosis 27923459 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNAs in lipid metabolism and atherosclerosis. other hsa-mir-33b Atherosclerosis 22274626 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. other hsa-mir-342 Atherosclerosis 23513069 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1-and microRNA-155-Dependent Pathway during Atherosclerosis other hsa-mir-34a Atherosclerosis 20627091 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MiR-34a:MicroRNA-34a regulation of endothelial senescence other hsa-mir-34a Atherosclerosis 25395581 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 miR-34a is involved in the flow-dependent regulation of endothelial inflammation. other hsa-mir-422a Atherosclerosis 22370758 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Co-expression in plaque tissue and non-classical monocytes. other hsa-mir-494 Atherosclerosis 26583674 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Treatment with GSO-494 results in smaller atherosclerotic lesions with increased plaque stability. Inhibition of miR-494 may decrease the risk of surgical complications or even avert endarterectomy surgery in some cases. other hsa-mir-497 Atherosclerosis 27918592 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNA-497 Induces Apoptosis and Suppresses Proliferation via the Bcl-2/Bax-Caspase9-Caspase3 Pathway and Cyclin D2 Protein in HUVECs. other hsa-mir-548p Atherosclerosis 28336556 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis. other hsa-mir-712 Atherosclerosis 24346612 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. other hsa-mir-92a Atherosclerosis 27923459 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 MicroRNAs in lipid metabolism and atherosclerosis. other hsa-mir-98 Atherosclerosis 25623956 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Coculturing ECs with sSMCs under static condition causes initial increases of 4 anti-inflammatory miRs (146a/708/451/98) in ECs followed by decreases below basal levels at 7 days; other hsa-mir-98 Atherosclerosis 28436142 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Cortisol is associated with low frequency of interleukin 10-producing B cells in patients with atherosclerosis. other hsa-mir-99b Atherosclerosis 22370758 cardiovascular system disease DOID:1936 I70 D050197 108725 HP:0002621 Co-expression in plaque tissue and classical monocytes. other hsa-mir-155 Atopic Dermatitis 25761610 integumentary system disease DOID:3310 L20 D003876 PS603165 HP:0001047 MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells. other hsa-mir-155 Atopic Dermatitis 24521175 integumentary system disease DOID:3310 L20 D003876 PS603165 HP:0001047 The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding. other hsa-mir-1 Atrial Fibrillation 26221584 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. other hsa-mir-106b Atrial Fibrillation 24927531 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility. other hsa-mir-10a Atrial Fibrillation 26221584 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. other hsa-mir-10b Atrial Fibrillation 26221584 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. other hsa-mir-124 Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-126 Atrial Fibrillation 26313139 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 Biological significance of miR-126 expression in atrial fibrillation and heart failure. other hsa-mir-133a-1 Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-133a-2 Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-133b Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-146a Atrial Fibrillation 29437577 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation other hsa-mir-146b Atrial Fibrillation 25617731 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 miR-146b-5p probably acts as an intracellular mediator in the maladaptive remodeling in atrial fibrosis in atrial fibrillation. other hsa-mir-150 Atrial Fibrillation 24462065 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure. other hsa-mir-183 Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-192 Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-199a Atrial Fibrillation 25706326 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 Our combined transcriptomic analysis and miRNA microarray study of atrial samples from pAF patients revealed novel pathways and miRNA-mRNA regulations that may be relevant in the development of pAF. Future studies are required to investigate the potential involvement of the gonadotropin releasing hormone receptor and p53 pathways in AF pathogenesis. other hsa-mir-208b Atrial Fibrillation 27545043 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation. other hsa-mir-21 Atrial Fibrillation 26221584 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. other hsa-mir-215 Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-26b Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-29 Atrial Fibrillation 24085039 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 These new insights into mir29’s functions further support a role for the adaptive immune system in the immunopathogenesis of AF. We recommend that AF investigators team up with immunologists in search for pathogenic T cells. other hsa-mir-30a Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-30b Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-30c-1 Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-30c-2 Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-30d Atrial Fibrillation 22407060 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF other hsa-mir-355p Atrial Fibrillation 26567235 cardiovascular system disease DOID:0060224 I48.0 D001281 PS608583 HP:0005110 In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model. other hsa-mir-518a Atrioventricular Septal Defect 27396555 cardiovascular system disease DOID:0050651 Q21.2 D004694 PS606215 Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96. other hsa-mir-518e Atrioventricular Septal Defect 27396555 cardiovascular system disease DOID:0050651 Q21.2 D004694 PS606215 Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96. other hsa-mir-518f Atrioventricular Septal Defect 27396555 cardiovascular system disease DOID:0050651 Q21.2 D004694 PS606215 Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96. other hsa-mir-528a Atrioventricular Septal Defect 27396555 cardiovascular system disease DOID:0050651 Q21.2 D004694 PS606215 Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96. other hsa-mir-96 Atrioventricular Septal Defect 27396555 cardiovascular system disease DOID:0050651 Q21.2 D004694 PS606215 Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96. other hsa-mir-155 Atrophic Gastritis 21880981 gastrointestinal system disease DOID:8929 K29.4 D005757 MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis. other hsa-let-7g Atypical Teratoid Tumor 25638158 disease of cellular proliferation DOID:2129 609322 LIN28A knockdown led to increased expression of let-7b and let-7g microRNAs and a down-regulation of KRAS mRNA. other hsa-mir-140 Autism Spectrum Disorder 28848387 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 Expression and Regulatory Network Analysis of miR-140-3p, a New Potential Serum Biomarker for Autism Spectrum Disorder. other hsa-mir-182 Autism Spectrum Disorder 28617945 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. other hsa-mir-184 Autism Spectrum Disorder 18203756 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 The restricted release of MeCP2 from the paternal allele results in paternal allele-specific expression of miR-184. Our finding provides a clue to the link between the microRNA and DNA methylation pathways. other hsa-mir-21 Autism Spectrum Disorder 27571009 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. other hsa-mir-212 Autism Spectrum Disorder 28617945 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. other hsa-mir-363 Autism Spectrum Disorder 28617945 disease of mental health DOID:0060041 F84.0 D000067877 209850 HP:0000729 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. other hsa-let-7a Autoimmune Diseases [unspecific] 25759134 D001327 607836 HP:0002960 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-10a Autoimmune Diseases [unspecific] 27687891 D001327 607836 HP:0002960 MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs other hsa-mir-125a Autoimmune Diseases [unspecific] 25963922 D001327 607836 HP:0002960 Using a chemically synthesized miR-125a analogue,we show potential to re-programme the immune homeostasis in EAE models. These findings point to miR-125a as a critical factor that controls autoimmune diseases by stabilizing Treg-mediated immune homeostasis. other hsa-mir-126 Autoimmune Diseases [unspecific] 27687891 D001327 607836 HP:0002960 MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs other hsa-mir-142 Autoimmune Diseases [unspecific] 27943367 D001327 607836 HP:0002960 Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells. other hsa-mir-146a Autoimmune Diseases [unspecific] 24014244 D001327 607836 HP:0002960 Our data unravel the crucial immunomodulatory role of miR-146a in pDCs and may add to our understanding of aberrant responses in autoimmune diseases. other hsa-mir-146a Autoimmune Diseases [unspecific] 27943367 D001327 607836 HP:0002960 Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells. other hsa-mir-150 Autoimmune Diseases [unspecific] 26275076 D001327 607836 HP:0002960 dysregulated expression of miR-150 in immune cells might result in autoimmune diseases. other hsa-mir-155 Autoimmune Diseases [unspecific] 26674874 D001327 607836 HP:0002960 We have shown that mice in which the miR-155 host gene (MIR155HG) has been deactivated are resistant to EAE. other hsa-mir-155 Autoimmune Diseases [unspecific] 27687891 D001327 607836 HP:0002960 MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs other hsa-mir-200c Autoimmune Diseases [unspecific] 25759134 D001327 607836 HP:0002960 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-21 Autoimmune Diseases [unspecific] 27271606 D001327 607836 HP:0002960 miR-21 was found to be correlated with the pathogenesis of autoimmune diseases other hsa-mir-188 Azoospermia 27868267 reproductive system disease DOID:14227 N46.0 D053713 HP:0000027 Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia. other hsa-mir-143 Barrett Esophagus 19190970 gastrointestinal system disease DOID:9206 K22.7 D001471 614266 HP:0100580 miR-143: significantly higher other hsa-mir-31 Barrett Esophagus 22302717 gastrointestinal system disease DOID:9206 K22.7 D001471 614266 HP:0100580 The authors propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barrett's esophagus. other hsa-mir-375 Barrett Esophagus 22302717 gastrointestinal system disease DOID:9206 K22.7 D001471 614266 HP:0100580 The authors propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barrett's esophagus. other hsa-mir-34c Becker Muscular Dystrophy 29703249 musculoskeletal system disease DOID:9883 G71.0 300376 miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context. other hsa-mir-708 Becker Muscular Dystrophy 29703249 musculoskeletal system disease DOID:9883 G71.0 300376 miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context. other hsa-mir-196a2 Behcet Disease 27993883 cardiovascular system disease DOID:13241 M35.2 D001528 109650 Association of Reduced Heme Oxygenase-1 with Decreased MicroRNA-196a2 Expression in Peripheral Blood Mononuclear Cells of Patients with Intestinal Behcet's Disease. other hsa-mir-129 Biliary Atresia 27706677 gastrointestinal system disease DOID:13608 Q44.2 D001656 210500 Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models. other hsa-mir-155 Biliary Atresia 27817193 gastrointestinal system disease DOID:13608 Q44.2 D001656 210500 Effect of microRNA-155 on the interferon-gamma signaling pathway in biliary atresia. other hsa-mir-29a Biliary Atresia 22167021 gastrointestinal system disease DOID:13608 Q44.2 D001656 210500 MicroRNA Profiling Identifies miR-29 as a Regulator of Disease-Associated Pathways in Experimental Biliary Atresia. other hsa-mir-29b-1 Biliary Atresia 22167021 gastrointestinal system disease DOID:13608 Q44.2 D001656 210500 MicroRNA Profiling Identifies miR-29 as a Regulator of Disease-Associated Pathways in Experimental Biliary Atresia. other hsa-mir-29c Biliary Atresia 27706677 gastrointestinal system disease DOID:13608 Q44.2 D001656 210500 Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models. other hsa-mir-103-1 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-124 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-132 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-138 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-206 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-218-1 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-34a Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-449a Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-708 Bipolar Disorder 27864917 disease of mental health DOID:3312 F31 D001714 HP:0007302 Genetic variation in the miR-708 gene and its binding targets in bipolar disorder. other hsa-mir-9-3 Bipolar Disorder 25817407 disease of mental health DOID:3312 F31 D001714 HP:0007302 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-100 Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-100 Bladder Neoplasms 23945108 C67 D001749 109800 HP:0009725 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. other hsa-mir-101 Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-101 Bladder Neoplasms 25109742 C67 D001749 109800 HP:0009725 Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. other hsa-mir-101 Bladder Neoplasms 25658842 C67 D001749 109800 HP:0009725 miR-101 suppresses VEGF-C expression, inhibits cell migration and invasion, and increases cisplatin sensitivity in bladder cancer cells. other hsa-mir-101 Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-106b Bladder Neoplasms 25168920 C67 D001749 109800 HP:0009725 Urinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancer. other hsa-mir-10b Bladder Neoplasms 25620614 C67 D001749 109800 HP:0009725 urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial. other hsa-mir-125a Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-125b Bladder Neoplasms 20549700 C67 D001749 109800 HP:0009725 Taken together, miR-125b may act as a tumor suppressor in bladder urothelium, and downregulation of miR-125b may contribute to the tumorigenesis of bladder cancer. other hsa-mir-125b Bladder Neoplasms 28938585 C67 D001749 109800 HP:0009725 The trophoblast cell surface antigen 2 and miR-125b axis in urothelial bladder cancer. other hsa-mir-129 Bladder Neoplasms 19487295 C67 D001749 109800 HP:0009725 We identified several miRNAs with prognostic potential for predicting disease progression (e.g., miR-129, miR-133b, and miR-518c*). other hsa-mir-133b Bladder Neoplasms 19487295 C67 D001749 109800 HP:0009725 We identified several miRNAs with prognostic potential for predicting disease progression (e.g., miR-129, miR-133b, and miR-518c*). other hsa-mir-141 Bladder Neoplasms 25884322 C67 D001749 109800 HP:0009725 MiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer. Detection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND. other hsa-mir-143 Bladder Neoplasms 26356996 C67 D001749 109800 HP:0009725 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. other hsa-mir-143 Bladder Neoplasms 25804644 C67 D001749 109800 HP:0009725 The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients. other hsa-mir-143 Bladder Neoplasms 28123579 C67 D001749 109800 HP:0009725 miR-143 inhibits bladder cancer cell proliferation and enhances their sensitivity to gemcitabine by repressing IGF-1R signaling. other hsa-mir-145 Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-145 Bladder Neoplasms 26356996 C67 D001749 109800 HP:0009725 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. other hsa-mir-145 Bladder Neoplasms 25804644 C67 D001749 109800 HP:0009725 The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients. other hsa-mir-145 Bladder Neoplasms 26852750 C67 D001749 109800 HP:0009725 decreasing miR-145 expression reduced cisplatin sensitivity other hsa-mir-148a Bladder Neoplasms 25865490 C67 D001749 109800 HP:0009725 miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1. other hsa-mir-148b Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-151 Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-155 Bladder Neoplasms 25965824 C67 D001749 109800 HP:0009725 MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1. other hsa-mir-16 Bladder Neoplasms 23991964 C67 D001749 109800 HP:0009725 miR-16 is an important regulator in bladder cancer, which will contribute to better understanding of important mis-regulated miRNAs. other hsa-mir-16 Bladder Neoplasms 26373319 C67 D001749 109800 HP:0009725 Together, our results revealed that urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. other hsa-mir-17 Bladder Neoplasms 29386015 C67 D001749 109800 HP:0009725 Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression other hsa-mir-181b Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-182 Bladder Neoplasms 26356996 C67 D001749 109800 HP:0009725 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. other hsa-mir-183 Bladder Neoplasms 26356996 C67 D001749 109800 HP:0009725 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. other hsa-mir-192 Bladder Neoplasms 25566965 C67 D001749 109800 HP:0009725 miR-192 may be a suppressor for bladder cancer cells by cell cycle regulation. other hsa-mir-200a Bladder Neoplasms 20473948 C67 D001749 109800 HP:0009725 we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression. other hsa-mir-200b Bladder Neoplasms 25884322 C67 D001749 109800 HP:0009725 MiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer. Detection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND. other hsa-mir-200b Bladder Neoplasms 20473948 C67 D001749 109800 HP:0009725 we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression. other hsa-mir-200c Bladder Neoplasms 20473948 C67 D001749 109800 HP:0009725 we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression. other hsa-mir-205 Bladder Neoplasms 20473948 C67 D001749 109800 HP:0009725 we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression. other hsa-mir-21 Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-21 Bladder Neoplasms 25266796 C67 D001749 109800 HP:0009725 A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis. other hsa-mir-21 Bladder Neoplasms 22788411 C67 D001749 109800 HP:0009725 The effect of normalization was tested with miR-21 as the target gene, as this was previously suggested to be upregulated in cancer patients' serum. other hsa-mir-210 Bladder Neoplasms 25620614 C67 D001749 109800 HP:0009725 urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial. other hsa-mir-214 Bladder Neoplasms 25975233 C67 D001749 109800 HP:0009725 Urinary cell-free miR-214 is a hopeful biomarker for tumor stratification, early diagnosis and prognostic assessment of bladder cancer. other hsa-mir-221 Bladder Neoplasms 25620614 C67 D001749 109800 HP:0009725 urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial. other hsa-mir-221 Bladder Neoplasms 25585941 C67 D001749 109800 HP:0009725 The expression of MMP-2, MMP-9 and VEGF-C were reduced, resulting in reduced invasiveness and infiltration capability of bladder cancer cells, thereby inhibiting the immune evasion of bladder cancer cells. other hsa-mir-221 Bladder Neoplasms 28770966 C67 D001749 109800 HP:0009725 Inhibition of miR-221 influences bladder cancer cell proliferation and apoptosis. other hsa-mir-224 Bladder Neoplasms 25804644 C67 D001749 109800 HP:0009725 The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients. other hsa-mir-224 Bladder Neoplasms 29386015 C67 D001749 109800 HP:0009725 Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression other hsa-mir-23a Bladder Neoplasms 25620614 C67 D001749 109800 HP:0009725 urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial. other hsa-mir-23b Bladder Neoplasms 25405368 C67 D001749 109800 HP:0009725 RNA networks regulated by tumor-suppressive miR-23b/27b provide new insights into the potential mechanisms of BC oncogenesis and metastasis. other hsa-mir-27b Bladder Neoplasms 25405368 C67 D001749 109800 HP:0009725 RNA networks regulated by tumor-suppressive miR-23b/27b provide new insights into the potential mechanisms of BC oncogenesis and metastasis. other hsa-mir-29a Bladder Neoplasms 28687357 C67 D001749 109800 HP:0009725 Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway. other hsa-mir-29b Bladder Neoplasms 27322434 C67 D001749 109800 HP:0009725 miR-21 and miR-29b depression have been shown in Snail-1 suppressed group in EJ-138 cells in vitro. other hsa-mir-29c Bladder Neoplasms 24952510 C67 D001749 109800 HP:0009725 Down-regulation of miR-29c in human bladder cancer and the inhibition of proliferation in T24 cell via PI3K-AKT pathway. other hsa-mir-29c Bladder Neoplasms 25620614 C67 D001749 109800 HP:0009725 urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial. other hsa-mir-34a Bladder Neoplasms 25572695 C67 D001749 109800 HP:0009725 polyphenols in PRE can be potential molecular clusters to suppress bladder cancer cell EJ proliferation via p53/miR-34a axis. other hsa-mir-34a Bladder Neoplasms 23720881 C67 D001749 109800 HP:0009725 These findings suggest that the relative low expression of miRNA-34a might be involved in the tumorigenesis of bladder cancer. other hsa-mir-373 Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-449a Bladder Neoplasms 29659560 C67 D001749 109800 HP:0009725 Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration. other hsa-mir-451 Bladder Neoplasms 25550801 C67 D001749 109800 HP:0009725 miR451 should be a tumor-suppressing gene in bladder cancer. miR-451 could maintain the bladder tumor cells in epithelial phenotype, inhibit EMT process, thereby reducing the invasion and migration of tumor cells. other hsa-mir-503 Bladder Neoplasms 29169421 C67 D001749 109800 HP:0009725 miR-503-5p inhibits the proliferation of T24 and EJ bladder cancer cells by interfering with the Rb/E2F signaling pathway other hsa-mir-708 Bladder Neoplasms 23568547 C67 D001749 109800 HP:0009725 miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2 other hsa-mir-874 Bladder Neoplasms 22745731 C67 D001749 109800 HP:0009725 The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization. other hsa-mir-96 Bladder Neoplasms 26356996 C67 D001749 109800 HP:0009725 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. other hsa-mir-99a Bladder Neoplasms 23911686 C67 D001749 109800 HP:0009725 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. other hsa-mir-1 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-132 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-204 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-212 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-221 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-29 Bladder Outlet Obstruction 24340017 urinary system disease DOID:13948 N32.0 D001748 Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. other hsa-mir-29 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-30 Bladder Outlet Obstruction 26612603 urinary system disease DOID:13948 N32.0 D001748 We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. other hsa-mir-410 Blindness 27297412 nervous system disease DOID:1432 H54 HP:0000618 antisense microRNA-410 (anti-miR-410) induces RPE differentiation from amniotic epithelial stem cells. other hsa-mir-24 Blood Coagulation Disorders 28694557 D68.9 D001778 Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X. other hsa-mir-34a Bone Disease [unspecific] 28543623 musculoskeletal system disease DOID:0080001 M89.9 D001847 Regulatory effect of microRNA-34a on osteogenesis and angiogenesis in glucocorticoid-induced osteonecrosis of the femoral head. other hsa-mir-34c Bone Disease [unspecific] 27492554 musculoskeletal system disease DOID:0080001 M89.9 D001847 Taken together, our studies suggested that Icariine restored LPS-induced bone loss by downregulating miR-34c level and suppressing JNKs, p38, and NF-kB pathways, which highlighted the potential use of Icariine as a therapeutic agent in the treatment of bacteria-induced bone loss diseases. other hsa-mir-34c Bone Disease [unspecific] 27156573 musculoskeletal system disease DOID:0080001 M89.9 D001847 Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop. other hsa-let-7 Brain Disease [unspecific] 29408500 nervous system disease DOID:936 G93.40 D001927 608033 MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation other hsa-mir-132 Brain Disease [unspecific] 25957996 nervous system disease DOID:936 G93.40 D001927 608033 our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases. other hsa-mir-146a Brain Disease [unspecific] 25957996 nervous system disease DOID:936 G93.40 D001927 608033 our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases. other hsa-mir-155 Brain Disease [unspecific] 25957996 nervous system disease DOID:936 G93.40 D001927 608033 our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases. other hsa-mir-21 Brain Disease [unspecific] 28452880 nervous system disease DOID:936 G93.40 D001927 608033 Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury. other hsa-mir-27b Brain Disease [unspecific] 29050310 nervous system disease DOID:936 G93.40 D001927 608033 MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury other hsa-mir-29b Brain Disease [unspecific] 29087603 nervous system disease DOID:936 G93.40 D001927 608033 MiR-29b expression is associated with a dexmedetomidine-mediated protective effect against oxygen-glucose deprivation-induced injury to SK-N-SH cells in vitro. other hsa-mir-9 Brain Disease [unspecific] 20362537 nervous system disease DOID:936 G93.40 D001927 608033 These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs. other hsa-mir-106b Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-17 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-18 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-181c Brain Neoplasms 24867100 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma. other hsa-mir-19a Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-19b-1 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-20a Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-21 Brain Neoplasms 19175699 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 Since its identification 3 years ago as the miRNA most commonly and strongly up-regulated in human brain tumour glioblastoma [1], miR-21 has attracted the attention of researchers in various fields other hsa-mir-25 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-34a Brain Neoplasms 20190569 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 microRNA-34a is tumor suppressive in brain tumors and glioma stem cells other hsa-mir-520g Brain Neoplasms 26687818 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment. other hsa-mir-92-1 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-93 Brain Neoplasms 29547527 disease of cellular proliferation DOID:1319 C71 D001932 603688 HP:0030692 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors other hsa-mir-21 Breast Adenocarcinoma 28092843 thoracic disease DOID:3458 Moreover siRNA transfection had effects on breast adenocarcinoma cells and inhibits the migration (p<0.0001), proliferation (p<0.0001), cell cycle arrest (p=0.03) and induces apoptosis (p<0.0001) and reduces the expression of miR-21 (P=0.0014) other hsa-mir-10b Breast Ductal Carcinoma 29599829 thoracic disease DOID:3007 D05.10 D044584 miR-10b-positive expression was correlated with the expression of ER-α, Her-2 and the molecular subtypes of early invasive ductal carcinoma of the breast other hsa-mir-10b Breast Ductal Carcinoma 28512126 thoracic disease DOID:3007 D05.10 D044584 Tumor-associated myoepithelial cells promote the invasive progression of ductal carcinoma in situ through activation of TGFβ signaling. other hsa-mir-21 Breast Malignant Phyllodes Tumor 24980553 thoracic disease DOID:3016 D003557 miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. other hsa-let-7 Breast Neoplasms 23774803 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-let-7a Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7b Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7c Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7d Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7f Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7g Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7i Breast Neoplasms 24104964 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-let-7 Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-let-7a Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-let-7a Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-let-7a Breast Neoplasms 24942235 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations. other hsa-let-7a Breast Neoplasms 26924493 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Mir-206 and let-7 were up-regulated, and mir-21 expression was down-regulated in the exercise training compared to tumor group. other hsa-let-7a-1 Breast Neoplasms 21368581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. other hsa-let-7a-2 Breast Neoplasms 21368581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbe-induced oncomiR miRNA-181a. other hsa-let-7a-3 Breast Neoplasms 21368581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. other hsa-let-7c Breast Neoplasms 21409395 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells other hsa-let-7e Breast Neoplasms 24257477 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer. other hsa-let-7i Breast Neoplasms 24662829 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In breast cancer patients, significantly decreased let-7i levels were associated with missense mutations in p53. other hsa-mir-1 Breast Neoplasms 26275461 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer. other hsa-mir-1 Breast Neoplasms 26497855 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway. other hsa-mir-101 Breast Neoplasms 25059472 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-101 promotes breast cancer cell apoptosis by targeting Janus kinase 2. other hsa-mir-101 Breast Neoplasms 26360780 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7. other hsa-mir-103 Breast Neoplasms 22753153 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. other hsa-mir-103 Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-103a Breast Neoplasms 24865188 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients. other hsa-mir-106a Breast Neoplasms 24164962 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2. other hsa-mir-106b Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-107 Breast Neoplasms 20348243 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters. other hsa-mir-107 Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-10a Breast Neoplasms 25934412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The data presented supports a potential tumour suppressor role for miR-10a in breast cancer, and highlights retinoic acid as a positive regulator of the microRNA. other hsa-mir-10a Breast Neoplasms 29113237 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway. other hsa-mir-10b Breast Neoplasms 24457988 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Critical role of miR-10b in transforming growth factor-β1-induced epithelial-mesenchymal transition in breast cancer. other hsa-mir-10b Breast Neoplasms 24897960 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our results provide evidences that the addition of miR-10b RERs to the prognostic factors used in clinical routine could improve the prediction abilities for both overall mortality and disease progression in breast cancer patients. other hsa-mir-10b Breast Neoplasms 22020939 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Cysteine rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2(WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1{alpha}-TWIST signaling networks in human breast cancer cells. other hsa-mir-122 Breast Neoplasms 25078559 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression. other hsa-mir-122 Breast Neoplasms 25150312 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Breast cancer-specific TRAIL expression mediated by miRNA response elements of let-7 and miR-122. other hsa-mir-122 Breast Neoplasms 25621950 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression. other hsa-mir-1258 Breast Neoplasms 21266359 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase. other hsa-mir-125a Breast Neoplasms 26130254 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. other hsa-mir-125a Breast Neoplasms 23519125 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells other hsa-mir-125b Breast Neoplasms 24098452 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression of ENPEP and CK2-α was inversely correlated with miR-125b expression in breast tumors,indicating the relevance of these potential oncogenic proteins in breast cancer patients. other hsa-mir-125b Breast Neoplasms 24165569 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Taken together our results show a mechanism for EPO/EPOR and ERBB2 co-regulation in breast cancer and confirm the importance of miR-125b in controlling clinically-relevant cancer features. other hsa-mir-125b Breast Neoplasms 25539763 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 context-dependent roles are not clear in breast cancer, a diverse expression pattern of ALCAM mRNA was detected in a panel of breast cancer patient samples. Differentially expressed/regulated cancer-related genes upon miR-125b expression along with the significant increase of ALCAM are of future interest to understand how deregulated expression of miR-125b may have a tumor suppressor role in breast and other cancers. other hsa-mir-125b Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-mir-125b Breast Neoplasms 26130254 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. other hsa-mir-125b-1 Breast Neoplasms 23519125 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells other hsa-mir-125b-2 Breast Neoplasms 23519125 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells other hsa-mir-126 Breast Neoplasms 26926567 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. other hsa-mir-126 Breast Neoplasms 23396050 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-126 and miR-126(*) repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis other hsa-mir-1266 Breast Neoplasms 25640367 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast cancer patients. other hsa-mir-127 Breast Neoplasms 24155205 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-127 is downregulated by Tudor-SN protein and contributes to metastasis and proliferation in breast cancer cell line MDA-MB-231. other hsa-mir-1274b Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-mir-128 Breast Neoplasms 27322220 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-128 in exosomes negatively regulates the level of Bax in MCF-7 recipient cells and inhibits cell proliferation. other hsa-mir-128a Breast Neoplasms 20054641 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These data suggest that the hormone-responsive miR-128a can modulate TGFβ signaling and survival of the letrozole-resistant cell lines. other hsa-mir-128b Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-133a Breast Neoplasms 25051376 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 both miR-148b and miR-133a have potential use as biomarkers for breast cancer detection other hsa-mir-133a Breast Neoplasms 26107945 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2. other hsa-mir-134 Breast Neoplasms 26416415 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity. other hsa-mir-135a Breast Neoplasms 25680412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. other hsa-mir-137 Breast Neoplasms 26215676 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis. other hsa-mir-139 Breast Neoplasms 24158791 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-139-5p is a regulator of metastatic pathways in breast cancer. other hsa-mir-139 Breast Neoplasms 25680412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. other hsa-mir-139 Breast Neoplasms 23722663 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Some novel miRNAs without known association to breast cancer were also found, and the putative functions of their PINs were also elucidated. These include miR-139 and miR-383. other hsa-mir-140 Breast Neoplasms 26378051 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. other hsa-mir-140 Breast Neoplasms 23752191 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. other hsa-mir-141 Breast Neoplasms 26164002 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-141 as potential suppressor of β-catenin in breast cancer. other hsa-mir-143 Breast Neoplasms 25961039 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes. other hsa-mir-143 Breast Neoplasms 26439035 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 UCA1 can directly interact with miR-143, lower its expression and affect its downstream regulation. Therefore, the UCA1-miR-143 axis constitutes a part of the oncogenic role of UCA1 in breast cancer. other hsa-mir-143 Breast Neoplasms 22260523 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells. other hsa-mir-143 Breast Neoplasms 28933584 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143. other hsa-mir-144 Breast Neoplasms 25465851 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 4 miRNAs that are generally dysregulated in human pathologies. Although these markers are not specific to certain diseases they may add to the diagnosis in combination with other markers, building a specific signature. Besides these dysregulated miRNAs, we propose a set of constant miRNAs that may be used as control markers. other hsa-mir-144 Breast Neoplasms 26252024 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation,migration and invasion of breast cancer cells. other hsa-mir-145 Breast Neoplasms 25961039 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes. other hsa-mir-145 Breast Neoplasms 26324407 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells. other hsa-mir-145 Breast Neoplasms 19996288 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis. other hsa-mir-145 Breast Neoplasms 19730444 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. other hsa-mir-145 Breast Neoplasms 20818426 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. other hsa-mir-145 Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-146a Breast Neoplasms 26095299 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 our study provided new insights into the function of CXCR4 in breast cancer: it promotes tumor progression as both a protein-coding gene and a non-coding RNA, complicating the mechanism by which oncogenes promote tumor progression. other hsa-mir-146a Breast Neoplasms 21472990 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. other hsa-mir-146a Breast Neoplasms 22949171 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-146a suppresses metastatic activity in brain metastasis. other hsa-mir-146b Breast Neoplasms 24498150 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Unraveling the hidden heterogeneities of breast cancer based on functional miRNA cluster. other hsa-mir-146b Breast Neoplasms 21472990 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. other hsa-mir-148a Breast Neoplasms 25063027 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 our findings offer important new insights into the ability of estrogenic GPER signaling to trigger HLA-G expression through inhibiting miR-148a that supports immune evasion in breast cancer. other hsa-mir-148a Breast Neoplasms 25928008 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. other hsa-mir-148a Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-148b Breast Neoplasms 25051376 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 both miR-148b and miR-133a have potential use as biomarkers for breast cancer detection other hsa-mir-15 Breast Neoplasms 25594541 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the expression of the miR-15 family contributes to increased radiosensitivity of breast cancer cells by influencing G2/M checkpoint proteins. other hsa-mir-15 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-150 Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-153 Breast Neoplasms 23803066 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-153 silencing induces apoptosis in the MDA-MB-231 breast cancer cell line. other hsa-mir-153 Breast Neoplasms 27012032 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis. other hsa-mir-155 Breast Neoplasms 24840899 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: a meta-analysis. other hsa-mir-155 Breast Neoplasms 25086633 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. other hsa-mir-155 Breast Neoplasms 25484137 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 a role of miR-155 in thiamine homeostasis and suggests a function of this oncogenic miRNA on breast cancer metabolism. other hsa-mir-155 Breast Neoplasms 25523096 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. other hsa-mir-155 Breast Neoplasms 25744731 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Role of miR-155 in drug resistance of breast cancer. other hsa-mir-155 Breast Neoplasms 26795347 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors. other hsa-mir-155 Breast Neoplasms 21460854 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. other hsa-mir-155 Breast Neoplasms 22245916 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Up-regulated miR-155 expression was associated with lymph node positivity (P=0.034), higher proliferation index (Ki-67 >10%) (P=0.019) and advanced breast cancer TNM clinical stage (P=0.002). other hsa-mir-155 Breast Neoplasms 23302487 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-155, as an oncomir, promotes lymph node involvement and vascular invasion and accompanies over-expressed HER-2 on breast cancer FFPE tissue other hsa-mir-155 Breast Neoplasms 29214365 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Profiling differential microRNA expression between in situ, infiltrative and lympho-vascular space invasive breast cancer: a pilot study other hsa-mir-15a Breast Neoplasms 22335947 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression level of miR-15a in MCF-7 cells was lower than that in the MCF-10A cells (0.253:1, P < 0.0001). The expression of MiR-15a was significantly inhibited by Bcl-2 (P < 0.05). other hsa-mir-15a Breast Neoplasms 28337296 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Tumor suppressor p53 induces miR-15a processing to inhibit neuronal apoptosis inhibitory protein (NAIP) in the apoptotic response DNA damage in breast cancer cell. other hsa-mir-15a Breast Neoplasms 28509572 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. other hsa-mir-15b Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-15b Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-16 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-16 Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-16-1 Breast Neoplasms 22260523 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells. other hsa-mir-16-2 Breast Neoplasms 22260523 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells. other hsa-mir-17 Breast Neoplasms 24287487 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. other hsa-mir-17 Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-17 Breast Neoplasms 24658544 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. other hsa-mir-17 Breast Neoplasms 25001613 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer. other hsa-mir-17 Breast Neoplasms 26130254 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. other hsa-mir-17 Breast Neoplasms 20406904 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling other hsa-mir-17 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-18 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-181a-2 Breast Neoplasms 23774803 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-mir-181a-2 Breast Neoplasms 21368581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. other hsa-mir-181a-2 Breast Neoplasms 23759567 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. other hsa-mir-181b Breast Neoplasms 22009755 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen. other hsa-mir-181b-1 Breast Neoplasms 23759567 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. other hsa-mir-181b-2 Breast Neoplasms 23759567 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. other hsa-mir-181c Breast Neoplasms 25828099 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. other hsa-mir-182 Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-182 Breast Neoplasms 22086602 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. other hsa-mir-183 Breast Neoplasms 26400174 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In conclusion,our findings provide evidence that post-transcriptional studies of BRCA will benefit from transcending the one-locus-one-miRNA paradigm and taking into account all isoforms from each miRNA locus as well as the patient's race. other hsa-mir-184 Breast Neoplasms 26070602 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These studies elucidate a new layer of regulation in the PI3K/AKT/mTOR pathway with relevance to mammary development and tumour progression and identify miR-184 as a putative breast tumour suppressor. other hsa-mir-187 Breast Neoplasms 23060431 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro other hsa-mir-18a Breast Neoplasms 21755340 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-18a expression was much higher in ERa-negative than in ERa-positive tumors (P < 0.0001), with the expression levels of miR-18a not differing in ERa-positive breast cancer as a function of ERa protein level. other hsa-mir-18b Breast Neoplasms 19684618 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 inhibit Eralpha signaling other hsa-mir-18b Breast Neoplasms 21755340 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Low miR-18b expression was significantly associated with improved survival in HER2-negative breast cancer, although miR-18b expression was not correlated with ERa protein expression. other hsa-mir-19 Breast Neoplasms 24831732 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. other hsa-mir-191 Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-191 Breast Neoplasms 23505378 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status other hsa-mir-192 Breast Neoplasms 26642352 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells. other hsa-mir-193b Breast Neoplasms 25213330 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. other hsa-mir-193b Breast Neoplasms 25550792 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-193b as a novel tumor suppressor plays an important role in breast cancer progression, understanding the mechanisms could account for the aggressive behaviour of breast cancer. other hsa-mir-193b Breast Neoplasms 19684618 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 inhibit Eralpha signaling other hsa-mir-193b Breast Neoplasms 21755340 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased. other hsa-mir-193b Breast Neoplasms 21512034 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 we present here a proteomic screen to identify targets of miR-193b, and a systems biological approach to mimic its effects at the level of cellular phenotypes. other hsa-mir-194 Breast Neoplasms 23273170 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Manipulation of the miR-194 expression level using a synthetic inhibiting RNA produced a small but significant suppression of cell proliferation and upregulation in the expression of several genes that are thought to act as tumor suppressors in MCF-7 and T47D breast cancer cells. other hsa-mir-196a-1 Breast Neoplasms 23250869 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-alpha and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties other hsa-mir-196a-2 Breast Neoplasms 26886638 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. other hsa-mir-196a-2 Breast Neoplasms 23250869 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-alpha and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties other hsa-mir-199a Breast Neoplasms 26399456 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Thus, miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. other hsa-mir-199a-1 Breast Neoplasms 23337876 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy other hsa-mir-199a-2 Breast Neoplasms 23337876 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy other hsa-mir-199b Breast Neoplasms 26399456 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Thus, miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. other hsa-mir-19a Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-19a Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-19b-1 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-20 Breast Neoplasms 24658544 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. other hsa-mir-200 Breast Neoplasms 24037528 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. other hsa-mir-200 Breast Neoplasms 24518294 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer. other hsa-mir-200 Breast Neoplasms 24967704 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family. other hsa-mir-200 Breast Neoplasms 25086633 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. other hsa-mir-200 Breast Neoplasms 25401471 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 metastatic capability can be transferred by the uptake of extracellular vesicles. other hsa-mir-200 Breast Neoplasms 27257068 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-200 levels increase following hPMR1 knockdown, and changes in miR-200 family microRNAs were matched by corresponding changes in miR-200 targets and reporter expression. other hsa-mir-200a Breast Neoplasms 26088362 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. other hsa-mir-200a Breast Neoplasms 26283635 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells. other hsa-mir-200a Breast Neoplasms 24086551 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells. other hsa-mir-200a Breast Neoplasms 19839049 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-200a:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells other hsa-mir-200a Breast Neoplasms 23318438 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells other hsa-mir-200b Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-200b Breast Neoplasms 24086551 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells. other hsa-mir-200b Breast Neoplasms 19839049 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-200b:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells other hsa-mir-200b Breast Neoplasms 23318438 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells other hsa-mir-200c Breast Neoplasms 24754877 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. other hsa-mir-200c Breast Neoplasms 25746005 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. other hsa-mir-200c Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-200c Breast Neoplasms 19839049 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-200c:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells other hsa-mir-200c Breast Neoplasms 21553120 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor. other hsa-mir-200c Breast Neoplasms 22364742 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis. other hsa-mir-200c Breast Neoplasms 23318438 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells other hsa-mir-200c Breast Neoplasms 23546450 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling other hsa-mir-200c Breast Neoplasms 26310899 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 selected miRNAs, such as miR-200c and miR-34a, may influence response to chemotherapy in several tumor types other hsa-mir-200c Breast Neoplasms 29532351 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals other hsa-mir-200c Breast Neoplasms 21336307 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study elucidates a role for p53 in regulating EMT-MET (mesenchymal-epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to suppress EMT-associated cancer stem cells through activation of the p53-miR-200c pathway. other hsa-mir-200 Breast Neoplasms 26068592 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The upregulation of fibronectin and lysyl oxidase directly by miR-200 or indirectly through Fli-1 or TCF12 contributed to ECM remodeling, triggering the invasion and metastasis of breast cancer cells both in vitro and vivo other hsa-mir-203 Breast Neoplasms 26790955 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. other hsa-mir-203 Breast Neoplasms 21553120 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor. other hsa-mir-203 Breast Neoplasms 22260523 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells. other hsa-mir-204 Breast Neoplasms 26436206 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. other hsa-mir-204 Breast Neoplasms 22629385 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Gene expression analysis of miR-204 and miR-379-transfected cells indicated that these miRNAs downregulated the expression of several genes involved in TGF-β signaling, including prostaglandin-endoperoxide synthase 2 (PTGS2). other hsa-mir-205 Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-mir-205 Breast Neoplasms 21553120 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor. other hsa-mir-205 Breast Neoplasms 21787752 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 ErbB2 down-regulates microRNA-205 in breast cancer. other hsa-mir-205 Breast Neoplasms 22578566 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. other hsa-mir-205 Breast Neoplasms 23519125 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells other hsa-mir-205 Breast Neoplasms 23474752 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. other hsa-mir-206 Breast Neoplasms 26130254 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. other hsa-mir-206 Breast Neoplasms 19684618 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 inhibit Eralpha signaling other hsa-mir-206 Breast Neoplasms 21302623 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-206 may suppress invasion and migration of MDA-MB-231 cells in vitro partly via regulating actin cytoskeleton remodelling such as filopodia formation other hsa-mir-20a Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-20a Breast Neoplasms 24287487 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. other hsa-mir-20a Breast Neoplasms 20406904 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling other hsa-mir-20a Breast Neoplasms 22901144 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Differential Distribution of miR-20a and miR-20b may Underly Metastatic Heterogeneity of Breast Cancers. other hsa-mir-20b Breast Neoplasms 20406904 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling other hsa-mir-21 Breast Neoplasms 26026077 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-21 is a potential biomarker for breast cancer prognosis. other hsa-mir-21 Breast Neoplasms 23851508 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. other hsa-mir-21 Breast Neoplasms 24248894 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-21 in breast cancer: diagnostic and prognostic potential. other hsa-mir-21 Breast Neoplasms 24488617 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion. other hsa-mir-21 Breast Neoplasms 25523096 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. other hsa-mir-21 Breast Neoplasms 25706383 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our results indicated that miR-21 can predict unfavorable prognoses in breast cancer patients, especially in Asians. other hsa-mir-21 Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-mir-21 Breast Neoplasms 25735723 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-21 controls in situ expansion of CCR6 regulatory T cells through PTEN/AKT pathway in breast cancer. other hsa-mir-21 Breast Neoplasms 25880495 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Formulation of Anti-miR-21 and 4-Hydroxytamoxifen Co-loaded Biodegradable Polymer Nanoparticles and Their Antiproliferative Effect on Breast Cancer Cells. other hsa-mir-21 Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-21 Breast Neoplasms 26106867 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Successful attempts were made in applying the approach to detect miR-21 in human cell lysate samples of breast cancer patients. other hsa-mir-21 Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-mir-21 Breast Neoplasms 26270351 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Breast Cancer/Stromal Cells Coculture on Polyelectrolyte Films Emulates Tumor Stages and miRNA Profiles of Clinical Samples. other hsa-mir-21 Breast Neoplasms 26349663 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results indicate that miRNAs show promising associations with prognosis in breast cancer. Moreover, specific miRNAs such as miR-21 and miR-210 can predict poor survival rates in breast cancer patients. other hsa-mir-21 Breast Neoplasms 26411332 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The miR-21-triggered self-assembly of DNA nanostructures can also serve as a remarkable signal amplification platform to achieve ultrasensitive detection of miR-21 from as low as 10 MCF-7 human breast cancer cells. other hsa-mir-21 Breast Neoplasms 26486006 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Advances in Research on miR-21 and Breast Cancer. other hsa-mir-21 Breast Neoplasms 25784176 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21. other hsa-mir-21 Breast Neoplasms 18932017 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-21: High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1 other hsa-mir-21 Breast Neoplasms 20082533 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cells other hsa-mir-21 Breast Neoplasms 21131358 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Induction of MIR-21 by retinoic acid in estrogen-receptor-positive breast carcinoma cells: biological correlates and molecular targets other hsa-mir-21 Breast Neoplasms 21471222 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Upregulation of MIR-21 mediates resistance to trastuzumab therapy for breast cancer. other hsa-mir-21 Breast Neoplasms 22187223 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells. other hsa-mir-21 Breast Neoplasms 22618231 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells. other hsa-mir-21 Breast Neoplasms 23052036 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Endocrine Disruptors Fludioxonil and Fenhexamid Stimulate miR-21 Expression in Breast Cancer Cells other hsa-mir-21 Breast Neoplasms 23216894 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells other hsa-mir-21 Breast Neoplasms 26790955 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. other hsa-mir-21 Breast Neoplasms 22086602 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. other hsa-mir-21 Breast Neoplasms 26769851 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-21, a well-documented oncogenic miRNA for promoting tumor cell metastasis, was also found to be involved in inhibitory activity of SSA in breast tumor cell motility through the modulation of TGF尾 pathway. other hsa-mir-21 Breast Neoplasms 26924493 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Mir-206 and let-7 were up-regulated, and mir-21 expression was down-regulated in the exercise training compared to tumor group. other hsa-mir-21 Breast Neoplasms 27372573 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs. other hsa-mir-21 Breast Neoplasms 28509572 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. other hsa-mir-21 Breast Neoplasms 28628833 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer. other hsa-mir-210 Breast Neoplasms 24395300 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response. other hsa-mir-210 Breast Neoplasms 26349663 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results indicate that miRNAs show promising associations with prognosis in breast cancer. Moreover, specific miRNAs such as miR-21 and miR-210 can predict poor survival rates in breast cancer patients. other hsa-mir-210 Breast Neoplasms 24591754 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers. other hsa-mir-210 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-210: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-210 Breast Neoplasms 21738599 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. other hsa-mir-216b Breast Neoplasms 25078617 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Regulation of the P2X7R by microRNA-216b in human breast cancer. other hsa-mir-22 Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-22 Breast Neoplasms 26512777 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results provide mechanistic insight into TIP60 regulation and evidence for the utility of the combination of TIP60 and miR-22 as prognostic indicator of breast cancer progression. other hsa-mir-221 Breast Neoplasms 24197133 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 14-3-3ζ orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. other hsa-mir-221 Breast Neoplasms 24886939 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. other hsa-mir-221 Breast Neoplasms 24905916 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trail resistance induces epithelial-mesenchymal transition and enhances invasiveness by suppressing PTEN via miR-221 in breast cancer. other hsa-mir-221 Breast Neoplasms 25007959 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. other hsa-mir-221 Breast Neoplasms 25523096 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. other hsa-mir-221 Breast Neoplasms 18790736 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer other hsa-mir-221 Breast Neoplasms 21553120 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor. other hsa-mir-221 Breast Neoplasms 21755340 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased. other hsa-mir-221 Breast Neoplasms 25447917 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221-3p may give crucial information about molecular mechanism of the disease upon PAK1 activity or different mechanisms with respect to histopathology and severity of breast cancer. other hsa-mir-221 Breast Neoplasms 23529451 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221/222: promising biomarkers for breast cancer. other hsa-mir-221 Breast Neoplasms 23637992 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221 promotes tumorigenesis in human triple negative breast cancer cells. other hsa-mir-221 Breast Neoplasms 27031715 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 5-aza treatment caused an increase of miRNA-10b, -122, -200b levels in MCF-7/S cells, miRNA-34a, -10b, -122, -200b and -320a levels in MCF-7/Dox cells and miRNA-34a, -10b, -200b and -320a levels in MCF-7/DDP cells. other hsa-mir-221 Breast Neoplasms 27420990 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05); other hsa-mir-221 Breast Neoplasms 22009755 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen. other hsa-mir-222 Breast Neoplasms 23994196 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells. other hsa-mir-222 Breast Neoplasms 24886939 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. other hsa-mir-222 Breast Neoplasms 24923427 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Overall, this study suggested that both celecoxib and aspirin could prevent breast cancer growth by regulating proteins in the cell cycle and apoptosis without blocking estrogen synthesis. Besides, celecoxib might affect miR expression in an undesirable fashion. other hsa-mir-222 Breast Neoplasms 25007959 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. other hsa-mir-222 Breast Neoplasms 25562151 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 β-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells. other hsa-mir-222 Breast Neoplasms 25735339 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. other hsa-mir-222 Breast Neoplasms 18790736 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-222: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer other hsa-mir-222 Breast Neoplasms 21553120 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor. other hsa-mir-222 Breast Neoplasms 23529451 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-221/222: promising biomarkers for breast cancer. other hsa-mir-222 Breast Neoplasms 26432333 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 exosomes transmit drug resistance through delivering miR-222. other hsa-mir-222 Breast Neoplasms 27420990 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05) other hsa-mir-222 Breast Neoplasms 22009755 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen. other hsa-mir-223 Breast Neoplasms 24400121 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-223 is a coordinator of breast cancer progression as revealed by bioinformatics predictions. other hsa-mir-223 Breast Neoplasms 24727437 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. other hsa-mir-23a Breast Neoplasms 25445205 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The overall concordance rates between miR-23a with HRG and FOXM1 tissue RNAs were 91% and 79%, respectively. The median follow-up period was 49 months. mi-23a and HRG RNA were significant independent prognostic markers in relapse-free survival. miR-23a may have an oncogenic function and enhance BC progression by directly activating FOXM1 and HRG at RNA level. other hsa-mir-23b Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-mir-23b Breast Neoplasms 24985346 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. other hsa-mir-23b Breast Neoplasms 23338610 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Pro-oncogenic factors miR-23b- and miR-27b are regulated by Her2/Neu, EGF, and TNFa in breast cancer other hsa-mir-24 Breast Neoplasms 23774803 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-mir-24 Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-24 Breast Neoplasms 29103019 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Propofol induces apoptosis of breast cancer cells by downregulation of miR-24 signal pathway. other hsa-mir-25 Breast Neoplasms 24398324 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. other hsa-mir-25 Breast Neoplasms 25523096 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. other hsa-mir-25 Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-25 Breast Neoplasms 29765562 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 A myriad of roles of miR-25 in health and disease. other hsa-mir-26a Breast Neoplasms 25434799 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer. other hsa-mir-26a-1 Breast Neoplasms 22094936 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer. other hsa-mir-26a-1 Breast Neoplasms 22384020 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. other hsa-mir-26a-2 Breast Neoplasms 22094936 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer. other hsa-mir-26a-2 Breast Neoplasms 22384020 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. other hsa-mir-27a Breast Neoplasms 20382698 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-27a:MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells other hsa-mir-27a Breast Neoplasms 23240057 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival other hsa-mir-27a Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-mir-27a Breast Neoplasms 29393459 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Liraglutide inhibits the proliferation and promotes the apoptosis of MCF-7 human breast cancer cells through downregulation of microRNA-27a expression other hsa-mir-27a Breast Neoplasms 26662313 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 knockdown of miR-27a by the specific inhibitors significantly increased the sensitivity of T-47D cells to cisplatin (CDDP) treatment. other hsa-mir-27a Breast Neoplasms 27372573 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs. other hsa-mir-27a Breast Neoplasms 19921425 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 We hypothesize that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk. other hsa-mir-27b Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-mir-27b Breast Neoplasms 26065921 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1. other hsa-mir-27b Breast Neoplasms 26130254 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. other hsa-mir-27b Breast Neoplasms 23240057 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival other hsa-mir-29 Breast Neoplasms 24289849 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The inhibitory role of Mir-29 in growth of breast cancer cells. other hsa-mir-29 Breast Neoplasms 25174825 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aberrant miR-29 expression may account for reduced NMI expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth. Reduction in NMI levels has a feed-forward impact on miR-29 levels. other hsa-mir-29a Breast Neoplasms 23994196 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells. other hsa-mir-29a Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-29a Breast Neoplasms 19247375 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-29a: miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context other hsa-mir-29a Breast Neoplasms 19567675 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 potentially oncogenic role in breast tumorigenesis; significantly associated with decreased breast cancer risk; mutant precursors of miR-196a-2 into breast cancer cells led to less efficient processing of the miRNA precursor to its mature form as well as diminished capacity to regulate target genes, further showed that cell cycle response to mutagen challenge was significantly enhanced; other hsa-mir-29a Breast Neoplasms 25562151 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 β-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells. other hsa-mir-29a Breast Neoplasms 25735339 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. other hsa-mir-29a Breast Neoplasms 28701793 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells. other hsa-mir-29b-1 Breast Neoplasms 21359530 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-29b regulates migration of human breast cancer cells. other hsa-mir-29b-2 Breast Neoplasms 21359530 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-29b regulates migration of human breast cancer cells. other hsa-mir-29c Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-301a Breast Neoplasms 21393507 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses. other hsa-mir-301b Breast Neoplasms 21393507 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses. other hsa-mir-302a Breast Neoplasms 23184229 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation other hsa-mir-302c Breast Neoplasms 19684618 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 inhibit Eralpha signaling other hsa-mir-30a Breast Neoplasms 20498642 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Mir-30:Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells other hsa-mir-30a Breast Neoplasms 27302063 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 regulation of lumen formation by miR-342 other hsa-mir-30a Breast Neoplasms 28461244 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect. other hsa-mir-30b Breast Neoplasms 22384020 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. other hsa-mir-30e Breast Neoplasms 25523096 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs. other hsa-mir-30e Breast Neoplasms 26057454 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 We highlighted a relevant and subtype-specific role in breast cancer for miR-30e* and demonstrated that adding miRNA markers to gene signatures and clinico-pathological features can help for a better prognostication. other hsa-mir-30e Breast Neoplasms 27012041 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Abnormal miRNA-30e Expression is Associated with Breast Cancer Progression. other hsa-mir-31 Breast Neoplasms 21406558 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Activation of miR-31 function in already-established metastases elicits metastatic regression. other hsa-mir-320b Breast Neoplasms 26178901 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity. other hsa-mir-320c Breast Neoplasms 26378051 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. other hsa-mir-324 Breast Neoplasms 26166821 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. other hsa-mir-326 Breast Neoplasms 19883630 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1 other hsa-mir-328 Breast Neoplasms 25824027 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells. other hsa-mir-335 Breast Neoplasms 26378051 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. other hsa-mir-335 Breast Neoplasms 22034498 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aryl Hydrocarbon Receptor (AHR) Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells. other hsa-mir-335 Breast Neoplasms 24942235 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations. other hsa-mir-335 Breast Neoplasms 22908280 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b. other hsa-mir-339 Breast Neoplasms 20932331 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. other hsa-mir-33a Breast Neoplasms 26507842 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These findings identified miR-33a as a negative regulator of breast cancer cell proliferation and metastasis. other hsa-mir-342 Breast Neoplasms 23408138 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-342 is associated with estrogen receptor-ж┿expression and response to tamoxifen in breast cancer other hsa-mir-34a Breast Neoplasms 25078559 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression. other hsa-mir-34a Breast Neoplasms 25562151 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 β-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells. other hsa-mir-34a Breast Neoplasms 25735339 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. other hsa-mir-34a Breast Neoplasms 25789847 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells. other hsa-mir-34a Breast Neoplasms 26359358 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These data provide evidence for the leptin-antagonist potential of HNK and reveal the involvement of LKB1 and miR-34a. other hsa-mir-34a Breast Neoplasms 26790955 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. other hsa-mir-34a Breast Neoplasms 25784176 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21. other hsa-mir-34a Breast Neoplasms 21399894 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 increased expression of miR-34a in an acquired model of docetaxel resistance in breast cancer. other hsa-mir-34a Breast Neoplasms 22102859 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-34a Expression Has an Effect for Lower Risk of Metastasis and Associates with Expression Patterns Predicting Clinical Outcome in Breast Cancer. other hsa-mir-34a Breast Neoplasms 29226432 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the intracellular function of miR-34a delivered by the nanocomplex to upregulate active Caspase-3 was imaged in real-time other hsa-mir-34b Breast Neoplasms 25647415 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. other hsa-mir-34b Breast Neoplasms 22439831 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-34b is associated with clinical outcome in triple-negative breast cancer patients.Expression levels of miR-34b significantly correlate with disease free survival (DFS) (p = 0.0020, log-rank test) and overall survival (OS) (p = 0.0008, log-rank test) of TNBC patients. other hsa-mir-34c Breast Neoplasms 25064703 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Together, our results support the role of miR-34c as a tumor suppressor miRNA also in breast cancer. other hsa-mir-34c Breast Neoplasms 25647415 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. other hsa-mir-3646 Breast Neoplasms 27045586 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-3646 Contributes to Docetaxel Resistance in Human Breast Cancer Cells by GSK-3β/β-Catenin Signaling Pathway. other hsa-mir-373 Breast Neoplasms 26122224 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 INFLUENCE OF miR-373 ON THE INVASION AND MIGRATION OF BREAST CANCER AND THE EXPRESSION LEVEL OF TARGET GENES TXNIP. other hsa-mir-373 Breast Neoplasms 26258411 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. other hsa-mir-373 Breast Neoplasms 28260305 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Effects of microRNA-373 on the proliferation and invasiveness of breast carcinoma and its mechanisms. other hsa-mir-374a Breast Neoplasms 23321667 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis other hsa-mir-375 Breast Neoplasms 25663261 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study demonstrated that formononetin promoted ERα-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ERα feedback loop. other hsa-mir-375 Breast Neoplasms 25680412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. other hsa-mir-375 Breast Neoplasms 26962366 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Hsa-miR-375 is a predictor of local control in early stage breast cancer. other hsa-mir-375 Breast Neoplasms 25613180 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 biochanin A promoted ERα-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ERα feedback loop. other hsa-mir-375 Breast Neoplasms 22508479 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. other hsa-mir-375 Breast Neoplasms 27372573 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs. other hsa-mir-376 Breast Neoplasms 26940843 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MIR376 as an important microRNA family for cancer formation and progression other hsa-mir-379 Breast Neoplasms 22629385 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Gene expression analysis of miR-204 and miR-379-transfected cells indicated that these miRNAs downregulated the expression of several genes involved in TGF-β signaling, including prostaglandin-endoperoxide synthase 2 (PTGS2). other hsa-mir-383 Breast Neoplasms 23722663 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Some novel miRNAs without known association to breast cancer were also found, and the putative functions of their PINs were also elucidated. These include miR-139 and miR-383. other hsa-mir-423 Breast Neoplasms 25663458 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Genetic analysis and preliminary function study of miR-423 in breast cancer. other hsa-mir-424 Breast Neoplasms 20348243 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters. other hsa-mir-425 Breast Neoplasms 23505378 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status other hsa-mir-429 Breast Neoplasms 25405387 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 our results offer an opportunity for further understanding of the recondite mechanisms underlying the bone metastasis of breast cancer. other hsa-mir-429 Breast Neoplasms 24086551 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells. other hsa-mir-449a Breast Neoplasms 29431182 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis other hsa-mir-451a Breast Neoplasms 26161389 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-451a Inhibited Cell Proliferation and Enhanced Tamoxifen Sensitive in Breast Cancer via Macrophage Migration Inhibitory Factor. other hsa-mir-451a Breast Neoplasms 18645025 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-451: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin other hsa-mir-452 Breast Neoplasms 24648265 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-452 contributes to the docetaxel resistance of breast cancer cells. other hsa-mir-452 Breast Neoplasms 25562151 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 β-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells. other hsa-mir-453 Breast Neoplasms 19028706 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 In contrast, the T allele attenuates the binding of miR-453, which might lead to a reduced miRNA-mediated ESR1 repression, in consequence higher ESR1 protein levels and an increased breast cancer risk. other hsa-mir-467 Breast Neoplasms 26018675 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Inhibition of hyperglycemia-induced angiogenesis and breast cancer tumor growth by systemic injection of microRNA-467 antagonist. other hsa-mir-4728 Breast Neoplasms 24828673 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 we present here an alternative mode of miRNA regulation and demonstrate this dual function of the HER2 locus, linking the two major biomarkers in breast cancer. other hsa-mir-484 Breast Neoplasms 25643696 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast Cancer. other hsa-mir-486 Breast Neoplasms 26378051 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. other hsa-mir-489 Breast Neoplasms 27171498 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-489 could reverse the chemoresistance of breast cancer via the PI3K-Akt pathway by targeting SPIN1. other hsa-mir-494 Breast Neoplasms 27216190 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Elevating Dicer expression increased levels of the AXL kinase targeting miRNA miR-494 other hsa-mir-496 Breast Neoplasms 24204564 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. other hsa-mir-499 Breast Neoplasms 26886638 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. other hsa-mir-505 Breast Neoplasms 22051041 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-505 is a novel tumor suppressive miRNA and inhibits cell proliferation by inducing apoptosis. We also find that Akt3, correlate inversely with miR-505, modulates drug sensitivity in MCF7-ADR. other hsa-mir-509 Breast Neoplasms 25659578 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-α. other hsa-mir-515 Breast Neoplasms 23928990 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation. other hsa-mir-515-1 Breast Neoplasms 23549953 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers other hsa-mir-515-2 Breast Neoplasms 23549953 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers other hsa-mir-516a-1 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-516a-2 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-516b-1 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-516b-2 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-526b Breast Neoplasms 25733698 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation. other hsa-mir-548c Breast Neoplasms 25802200 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 we showed that miR-548c-3p is implicated in doxorubicin-treated MCF-7 cell viability, suggesting a role for this miRNA in resistance. other hsa-mir-570 Breast Neoplasms 20348243 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters. other hsa-mir-573 Breast Neoplasms 25333258 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis. other hsa-mir-574 Breast Neoplasms 25560734 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 functional screening mediated by miRNA libraries can provide new insights into the genes essential for tamoxifen response in breast cancer. other hsa-mir-574 Breast Neoplasms 26416693 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. other hsa-mir-578 Breast Neoplasms 25333258 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis. other hsa-mir-584 Breast Neoplasms 23479725 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Micro-RNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1): New Signaling Route Through Which Transforming Growth Factor-Beta Mediates the Migration and Actin Dynamics of Breast Cancer Cells other hsa-mir-592 Breast Neoplasms 25680412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. other hsa-mir-608 Breast Neoplasms 26886638 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study. other hsa-mir-618 Breast Neoplasms 20348243 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters. other hsa-mir-621 Breast Neoplasms 25867061 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. other hsa-mir-660 Breast Neoplasms 26416693 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. other hsa-mir-7 Breast Neoplasms 25511742 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-7-5p has a critical function through blocking REGγ in breast cancer cells. other hsa-mir-7 Breast Neoplasms 24707474 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. other hsa-mir-7 Breast Neoplasms 18922890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Finally, we show that miR-7 introduction inhibits the motility, invasiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer cells. other hsa-mir-708 Breast Neoplasms 23328481 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Our findings uncover a mechanistic role for miR-708 in metastasis and provide arationale for developing miR-708 as a therapeutic agent against metastatic breast cancer. other hsa-mir-7-1 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-7-1 Breast Neoplasms 23227519 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma other hsa-mir-7-2 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-7-2 Breast Neoplasms 23227519 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma other hsa-mir-720 Breast Neoplasms 25722304 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. other hsa-mir-7-3 Breast Neoplasms 18755890 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer other hsa-mir-7-3 Breast Neoplasms 23227519 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma other hsa-mir-760 Breast Neoplasms 25661353 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Systematic analysis of gene expression pattern in has-miR-760 overexpressed resistance of the MCF-7 human breast cancer cell to doxorubicin. other hsa-mir-760 Breast Neoplasms 20348243 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters. other hsa-mir-892b Breast Neoplasms 26747895 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 miR-892b Silencing Activates NF-κB and Promotes Aggressiveness in Breast Cancer. other hsa-mir-9 Breast Neoplasms 25017439 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 FOXO1 3'UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity. other hsa-mir-9 Breast Neoplasms 25086633 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. other hsa-mir-9 Breast Neoplasms 25680412 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. other hsa-mir-9 Breast Neoplasms 27468688 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts. other hsa-mir-9 Breast Neoplasms 20173743 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin. other hsa-mir-9 Breast Neoplasms 28345661 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients. other hsa-mir-92-1 Breast Neoplasms 26046581 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. other hsa-mir-92a Breast Neoplasms 22482439 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 We found that miR-221 levels are prognostic in breast cancer illustrating the high-throughput method and confirming that miRNAs can be valuable biomarkers in cancer. other hsa-mir-92a-1 Breast Neoplasms 22563438 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. other hsa-mir-92a-2 Breast Neoplasms 22563438 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. other hsa-mir-93 Breast Neoplasms 25238878 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 Identification of microRNA-93 as a functional dysregulated miRNA in triple-negative breast cancer. other hsa-mir-96 Breast Neoplasms 25907662 thoracic disease DOID:1612 C50 D001943 114480 HP:0100013 These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA. other hsa-mir-144 Bronchiolitis Obliterans Syndrome 26874429 respiratory system disease DOID:2799 J42 D001989 HP:0011946 MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. other hsa-mir-144 Bronchiolitis Obliterans Syndrome 27044533 respiratory system disease DOID:2799 J42 D001989 HP:0011946 MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. other hsa-mir-21 Bronchiolitis Obliterans Syndrome 27564214 respiratory system disease DOID:2799 J42 D001989 HP:0011946 Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study. other hsa-mir-34a Bronchiolitis Obliterans Syndrome 27564214 respiratory system disease DOID:2799 J42 D001989 HP:0011946 Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study. other hsa-mir-16 Bronchopulmonary Dysplasia 28381639 P27.1 D001997 Thus the intergenerational effects of gestational SS involve epigenetic regulation of HIF-1α through specific miRs contributing to increased incidence of AA and BPD in the progenies other hsa-mir-29b Bronchopulmonary Dysplasia 28473324 P27.1 D001997 miR-29b supplementation decreases expression of matrix proteins and improves alveolarization in mice exposed to maternal inflammation and neonatal hyperoxia. other hsa-mir-125b Carcinoma, Adrenocortical 24205079 endocrine system disease DOID:3948 D018268 202300 HP:0006744 miR-125b, miRNA-200b, miR-122, miRNA-466b, miR-138,vmiRNA-214, miRNA-503 and miRNA27a were down-regulated in response to 17α-E2 treatment. other hsa-mir-132 Carcinoma, Adrenocortical 24205079 endocrine system disease DOID:3948 D018268 202300 HP:0006744 ACTH up-regulated the expression of miRNA-212, miRNA-182, miRNA-183, miRNA-132, and miRNA-96 and down-regulated the levels of miRNA-466b, miRNA-214, miRNA-503, and miRNA-27a. other hsa-mir-210 Carcinoma, Adrenocortical 27550961 endocrine system disease DOID:3948 D018268 202300 HP:0006744 Preclinical progress and first translational steps for a liposomal chemotherapy protocol against adrenocortical carcinoma. other hsa-mir-212 Carcinoma, Adrenocortical 24205079 endocrine system disease DOID:3948 D018268 202300 HP:0006744 The levels of miR-212,miRNA-183, miRNA-182, miRNA-132, miRNA-370, miRNA-377, and miRNA-96 were up-regulated, whereas miR-125b, miRNA-200b, miR-122, miRNA-466b, miR-138, miRNA-214, miRNA-503 and miRNA27a were down-regulated in response to 17α-E2 treatment. other hsa-mir-146a Carcinoma, Basal Cell 20680470 disease of cellular proliferation DOID:2513 C44.91 D002280 605462 HP:0002671 These findings suggest that this functional SNP in pre-miR-146a could contribute to ESCC susceptibility and clinical outcome. other hsa-mir-1246 Carcinoma, Biliary Tract 27573701 disease of cellular proliferation DOID:4897 K83.9 D001650 HP:0030153 miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. other hsa-mir-200 Carcinoma, Biliary Tract 27941621 disease of cellular proliferation DOID:4897 K83.9 D001650 HP:0030153 Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients. other hsa-mir-205 Carcinoma, Biliary Tract 27941621 disease of cellular proliferation DOID:4897 K83.9 D001650 HP:0030153 Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients. other hsa-mir-4644 Carcinoma, Biliary Tract 27573701 disease of cellular proliferation DOID:4897 K83.9 D001650 HP:0030153 miR‑1246 and miR‑4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. other hsa-mir-100 Carcinoma, Bladder 28229968 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. other hsa-mir-125b Carcinoma, Bladder 28347246 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer. other hsa-mir-145 Carcinoma, Bladder 28106737 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells. other hsa-mir-148a Carcinoma, Bladder 27906180 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. other hsa-mir-203 Carcinoma, Bladder 28229968 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. other hsa-mir-21 Carcinoma, Bladder 28139790 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN. other hsa-mir-223 Carcinoma, Bladder 27744452 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p. other hsa-mir-223 Carcinoma, Bladder 28222670 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion. other hsa-mir-3658 Carcinoma, Bladder 27820650 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 Upregulation of miR-3658 in bladder cancer and tumor progression. other hsa-mir-489 Carcinoma, Bladder 28281959 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 miR-489 Suppresses Proliferation and Invasion of Human Bladder Cancer Cells. other hsa-mir-576 Carcinoma, Bladder 28338199 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 MiR-576-3p is a novel marker correlated with poor clinical outcome in bladder cancer. other hsa-mir-892b Carcinoma, Bladder 27573859 urinary system disease DOID:4007 D09.0 D001749 109800 HP:0002862 MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways. other hsa-let-7 Carcinoma, Breast 27574028 D05 D001943 114480 HP:0003002 Let‑7 miRNAs sensitize breast cancer stem cells to radiation‑induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathway. other hsa-let-7a Carcinoma, Breast 25669981 D05 D001943 114480 HP:0003002 Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA. other hsa-mir-101 Carcinoma, Breast 28109909 D05 D001943 114480 HP:0003002 ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer. other hsa-mir-122 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-125a Carcinoma, Breast 27651454 D05 D001943 114480 HP:0003002 Structural dynamics control the MicroRNA maturation pathway. other hsa-mir-126 Carcinoma, Breast 28125889 D05 D001943 114480 HP:0003002 Micro RNA-126 coordinates cell behavior and signaling cascades according to characteristics of breast cancer cells. other hsa-mir-127 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-139 Carcinoma, Breast 27864119 D05 D001943 114480 HP:0003002 Role of miR-139 as a surrogate marker for tumor aggression in breast cancer. other hsa-mir-155 Carcinoma, Breast 27470349 D05 D001943 114480 HP:0003002 Therefore, through the anti-glycolytic effect and breakage of the JAK/STAT3/SOCS1 feedback loop via miR-155-5p, 3B may potentially serve as a potential therapeutic agent against breast cancer. other hsa-mir-155 Carcinoma, Breast 28338193 D05 D001943 114480 HP:0003002 Oncogenic miR-155 down-regulated upon activation of antitumor cytotoxic T lymphocytes by the fusion of dendritic cells with breast carcinoma cells. other hsa-mir-17 Carcinoma, Breast 27811009 D05 D001943 114480 HP:0003002 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. other hsa-mir-17 Carcinoma, Breast 28178652 D05 D001943 114480 HP:0003002 STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. other hsa-mir-182 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-183 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-184 Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-18a Carcinoma, Breast 24633304 D05 D001943 114480 HP:0003002 Our findings identify a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers. other hsa-mir-200b Carcinoma, Breast 28152297 D05 D001943 114480 HP:0003002 miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins other hsa-mir-200c Carcinoma, Breast 25967125 D05 D001943 114480 HP:0003002 our data suggests that expression of miR-200c-141 and ∆Np63 in D492M can reverse EMT resulting in luminal- and myoepithelial differentiation, respectively,demonstrating the importance of these molecules in epithelial integrity in the human breast. other hsa-mir-200c Carcinoma, Breast 28003747 D05 D001943 114480 HP:0003002 MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell. other hsa-mir-200c Carcinoma, Breast 28334634 D05 D001943 114480 HP:0003002 E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. other hsa-mir-205 Carcinoma, Breast 28346474 D05 D001943 114480 HP:0003002 The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model. other hsa-mir-206 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-20a Carcinoma, Breast 27811009 D05 D001943 114480 HP:0003002 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. other hsa-mir-21 Carcinoma, Breast 26008976 D05 D001943 114480 HP:0003002 Our data revealed tissue specific changes of extracellular circulating miRNAs that would be otherwise unraveled using blood samples. other hsa-mir-21 Carcinoma, Breast 27579604 D05 D001943 114480 HP:0003002 Distinct Small RNA Signatures in Extracellular Vesicles Derived from Breast Cancer Cell Lines. other hsa-mir-21 Carcinoma, Breast 27836600 D05 D001943 114480 HP:0003002 A novel method for sensitive microRNA detection: Electropolymerization based doping. other hsa-mir-21 Carcinoma, Breast 28115844 D05 D001943 114480 HP:0003002 Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells. other hsa-mir-214 Carcinoma, Breast 28051254 D05 D001943 114480 HP:0003002 MiR-214 negatively regulates proliferation and WNT/β-catenin signaling in breast cancer. other hsa-mir-217 Carcinoma, Breast 28152297 D05 D001943 114480 HP:0003002 miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins other hsa-mir-221 Carcinoma, Breast 27686606 D05 D001943 114480 HP:0003002 A small RNA (miR-221) target was determined via the impedimetric measurement of the hybridization event in a label-free and PCR-free approach other hsa-mir-221 Carcinoma, Breast 27940575 D05 D001943 114480 HP:0003002 mda-7/IL-24 Mediates Cancer Cell-Specific Death via Regulation of miR-221 and the Beclin-1 Axis. other hsa-mir-221 Carcinoma, Breast 28191469 D05 D001943 114480 HP:0003002 RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site. other hsa-mir-221 Carcinoma, Breast 28202520 D05 D001943 114480 HP:0003002 Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles. other hsa-mir-221 Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-222 Carcinoma, Breast 27569215 D05 D001943 114480 HP:0003002 Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. other hsa-mir-222 Carcinoma, Breast 27699665 D05 D001943 114480 HP:0003002 miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27kip1 pathway. other hsa-mir-223 Carcinoma, Breast 27569215 D05 D001943 114480 HP:0003002 Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. other hsa-mir-23a Carcinoma, Breast 24806942 D05 D001943 114480 HP:0003002 Downregulation of SP1 and increased miR-23a levels in MSCs after contact with tumor cell medium as well as enhanced TGF尾1 expression were identified as potential molecular regulators of CXCL12 activity in MSCs. other hsa-mir-27a Carcinoma, Breast 27779715 D05 D001943 114480 HP:0003002 miR-27a-mediated antiproliferative effects of metformin on the breast cancer cell line MCF-7. other hsa-mir-27a Carcinoma, Breast 27811009 D05 D001943 114480 HP:0003002 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. other hsa-mir-29a Carcinoma, Breast 27523474 D05 D001943 114480 HP:0003002 miR-29a may be a potential target for the patients who acquired ADR-resistance during the treatment of breast cancer. other hsa-mir-29a Carcinoma, Breast 27986463 D05 D001943 114480 HP:0003002 Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells. other hsa-mir-29a Carcinoma, Breast 28186968 D05 D001943 114480 HP:0003002 XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p. other hsa-mir-29a Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-29b Carcinoma, Breast 27986463 D05 D001943 114480 HP:0003002 Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells. other hsa-mir-29a Carcinoma, Breast 25656908 D05 D001943 114480 HP:0003002 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. other hsa-mir-29b Carcinoma, Breast 25656908 D05 D001943 114480 HP:0003002 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. other hsa-mir-29c Carcinoma, Breast 25656908 D05 D001943 114480 HP:0003002 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. other hsa-mir-30 Carcinoma, Breast 28347244 D05 D001943 114480 HP:0003002 The miR-30 family: Versatile players in breast cancer. other hsa-mir-324 Carcinoma, Breast 27798879 D05 D001943 114480 HP:0003002 MicroRNA-324 in Human Cancer: miR-324-5p and miR-324-3p Have Distinct Biological Functions in Human Cancer. other hsa-mir-335 Carcinoma, Breast 28008602 D05 D001943 114480 HP:0003002 MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. other hsa-mir-34a Carcinoma, Breast 28334277 D05 D001943 114480 HP:0003002 In bone metastasis miR-34a-5p absence inversely correlates with Met expression, while Met oncogene is unaffected by miR-34a-5p in non-metastatic and metastatic breast carcinomas. other hsa-mir-363 Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-375 Carcinoma, Breast 23791885 D05 D001943 114480 HP:0003002 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. other hsa-mir-375 Carcinoma, Breast 28300567 D05 D001943 114480 HP:0003002 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models. other hsa-mir-375 Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-4443 Carcinoma, Breast 27504971 D05 D001943 114480 HP:0003002 We revealed that miR-4443 induced malignancy of breast cancer mainly in chemo-resistance aspect for the very first time, providing a novel biomarker in breast cancer diagnosis and therapy. other hsa-mir-455 Carcinoma, Breast 28335433 D05 D001943 114480 HP:0003002 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. other hsa-mir-485 Carcinoma, Breast 23886178 D05 D001943 114480 HP:0003002 miR-485 acts as a tumor suppressor by inhibiting cell growth and migration in breast carcinoma T47D cells. other hsa-mir-503 Carcinoma, Breast 27539783 D05 D001943 114480 HP:0003002 An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells. other hsa-mir-650 Carcinoma, Breast 28101578 D05 D001943 114480 HP:0003002 A 22q11.2 amplification in the region encoding microRNA-650 correlates with the epithelial to mesenchymal transition in breast cancer primary cultures of Mexican patients. other hsa-mir-660 Carcinoma, Breast 28252173 D05 D001943 114480 HP:0003002 Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer. other hsa-mir-7 Carcinoma, Breast 28571043 D05 D001943 114480 HP:0003002 MicroRNA-7 suppresses the homing and migration potential of human endothelial cells to highly metastatic human breast cancer cells. other hsa-mir-760 Carcinoma, Breast 27981531 D05 D001943 114480 HP:0003002 miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in breast cancer cells. other hsa-mir-765 Carcinoma, Breast 26398721 D05 D001943 114480 HP:0003002 These results provided novel insight into the regulatory mechanism of EMP3 in primary breast carcinoma. other hsa-mir-98 Carcinoma, Breast 28232182 D05 D001943 114480 HP:0003002 SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. other hsa-mir-128 Carcinoma, Breast, Triple Negative 24485087 D064726 This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells. other hsa-mir-15a Carcinoma, Breast, Triple Negative 24485087 D064726 This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells. other hsa-mir-15b Carcinoma, Breast, Triple Negative 24485087 D064726 This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells. other hsa-mir-16 Carcinoma, Breast, Triple Negative 24485087 D064726 This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells. other hsa-mir-190a Carcinoma, Breast, Triple Negative 24865188 D064726 Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients. other hsa-mir-200b Carcinoma, Breast, Triple Negative 24865188 D064726 Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients. other hsa-mir-200c Carcinoma, Breast, Triple Negative 29666469 D064726 the new p53/miR-30a/ZEB2 axis controls tumor cell invasion and distal spreading and impinges upon miR-200c expression other hsa-mir-205 Carcinoma, Breast, Triple Negative 25792283 D064726 Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition. other hsa-mir-210 Carcinoma, Breast, Triple Negative 28402752 D064726 The MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer. other hsa-mir-211 Carcinoma, Breast, Triple Negative 25680404 D064726 MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration. other hsa-mir-34c Carcinoma, Breast, Triple Negative 28069384 D064726 Regulation of cancerous progression and epithelial-mesenchymal transition by miR-34c-3p via modulation of MAP3K2 signaling in triple-negative breast cancer cells. other hsa-mir-93 Carcinoma, Breast, Triple Negative 24865188 D064726 Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients. other hsa-mir-93 Carcinoma, Breast, Triple Negative 27840899 D064726 miR-93 inhibits the invasive potential of triple-negative breast cancer cells in vitro via protein kinase WNK1. other hsa-mir-940 Carcinoma, Breast, Triple Negative 27731867 D064726 MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer. other hsa-let-7a Carcinoma, Cervical 26209160 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs. other hsa-let-7a Carcinoma, Cervical 27748903 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Let‑7a suppresses cell proliferation via the TGF‑β/SMAD signaling pathway in cervical cancer. other hsa-mir-106b Carcinoma, Cervical 26769181 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Our data suggest that the TGF-β1/miR-106b/DAB2 axis may be involved in the pathogenesis of cervical carcinoma. other hsa-mir-124 Carcinoma, Cervical 27806357 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Virtues and Weaknesses of DNA Methylation as a Test for Cervical Cancer Prevention. other hsa-mir-125b Carcinoma, Cervical 24402874 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a. other hsa-mir-126 Carcinoma, Cervical 24377569 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 miR-126 Suppresses the proliferation of cervical cancer cells and alters cell sensitivity to the chemotherapeutic drug bleomycin other hsa-mir-145 Carcinoma, Cervical 25666710 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells. other hsa-mir-145 Carcinoma, Cervical 28112371 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells. other hsa-mir-146a Carcinoma, Cervical 24406730 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. other hsa-mir-155 Carcinoma, Cervical 27717891 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population. other hsa-mir-18a Carcinoma, Cervical 25963391 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis. other hsa-mir-205 Carcinoma, Cervical 28304186 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. other hsa-mir-20a Carcinoma, Cervical 23819812 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Our results suggested that the circulating miR-20a may be a potential biomarker for detecting the lymph node status of cervical cancer patients. other hsa-mir-20a Carcinoma, Cervical 25803820 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MiR-20a promotes cervical cancer proliferation and metastasis in vitro and in vivo. other hsa-mir-21 Carcinoma, Cervical 24406730 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. other hsa-mir-21 Carcinoma, Cervical 26051842 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Overall, our study suggests that the microRNAs, miR-21 and let-7a function as clinically relevant integral components of STAT3 signaling and are responsible for maintaining activated state of STAT3 in HPV-infected cells during cervical carcinogenesis. other hsa-mir-218 Carcinoma, Cervical 24843318 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. other hsa-mir-223 Carcinoma, Cervical 26617846 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 In conclusion, miR-223 inhibited cell metastasis of human cervical cancer by modulating epithelial-mesenchymal transition. other hsa-mir-23b Carcinoma, Cervical 28077801 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3. other hsa-mir-29b Carcinoma, Cervical 28122338 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer. other hsa-mir-31 Carcinoma, Cervical 25894339 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Our results suggested that miR-31 plays an oncogenetic role in the development and progression of cervical cancer. other hsa-mir-335 Carcinoma, Cervical 25712373 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-335 represents an independent prognostic marker in cervical cancer. other hsa-mir-34a Carcinoma, Cervical 24402874 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a. other hsa-mir-34a Carcinoma, Cervical 26209160 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs. other hsa-mir-361 Carcinoma, Cervical 24158756 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-361-5p facilitates cervical cancer progression through mediation of epithelial-to-mesenchymal transition. other hsa-mir-375 Carcinoma, Cervical 25330011 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT. other hsa-mir-494 Carcinoma, Cervical 25877755 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MiRNA-494 inhibits metastasis of cervical cancer through Pttg1. other hsa-mir-9 Carcinoma, Cervical 25344913 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 Activation of miR-9 by human papillomavirus in cervical cancer. other hsa-mir-92a Carcinoma, Cervical 28081742 disease of cellular proliferation DOID:2893 D06.9 D002583 603956 HP:0030159 MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression. other hsa-let-7 Carcinoma, Colon 27789274 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. other hsa-mir-1 Carcinoma, Colon 28560697 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. other hsa-mir-103a Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-106a Carcinoma, Colon 26224446 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer. other hsa-mir-106b Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-122 Carcinoma, Colon 24898807 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. other hsa-mir-126 Carcinoma, Colon 25199818 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The current population based study of patients operated for stage II colon cancer demonstrated correlations between several prognostic unfavourable characteristics and miRNA-126 and argues for a possible prognostic impact on overall survival. An influence on survival by the MVD estimate was not detected. other hsa-mir-135b Carcinoma, Colon 24735923 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. other hsa-mir-139 Carcinoma, Colon 25550849 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-139-3p has potential as a prognostic biomarker for colon cancer. Further prospective studies are required to validate this result. other hsa-mir-141 Carcinoma, Colon 28739727 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. other hsa-mir-143 Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-145 Carcinoma, Colon 28272349 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. other hsa-mir-145 Carcinoma, Colon 29360852 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 We show that approximately 100 proteins are differentially expressed in HCT116 human colon cancer cells stably transduced with miR-143 or miR-145 compared to Empty control cells other hsa-mir-146 Carcinoma, Colon 28272349 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. other hsa-mir-146a Carcinoma, Colon 28466779 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-146a induces immune suppression and drug-resistant colorectal cancer cells. other hsa-mir-155 Carcinoma, Colon 26744471 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer. other hsa-mir-155 Carcinoma, Colon 28259135 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene. other hsa-mir-17 Carcinoma, Colon 28272349 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. other hsa-mir-185 Carcinoma, Colon 25216407 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia-inducible factor-2α pathway in vitro and in vivo. other hsa-mir-186 Carcinoma, Colon 28302487 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. other hsa-mir-192 Carcinoma, Colon 24213572 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-192 suppresses liver metastasis of colon cancer. other hsa-mir-192 Carcinoma, Colon 27793841 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. other hsa-mir-199a Carcinoma, Colon 28542779 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. other hsa-mir-199b Carcinoma, Colon 28542779 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. other hsa-mir-200 Carcinoma, Colon 25832648 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro. other hsa-mir-200 Carcinoma, Colon 27460529 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family. other hsa-mir-200 Carcinoma, Colon 27666412 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro. other hsa-mir-200 Carcinoma, Colon 28163188 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). other hsa-mir-200b Carcinoma, Colon 28163188 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). other hsa-mir-200c Carcinoma, Colon 28163188 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). other hsa-mir-203 Carcinoma, Colon 27771718 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. other hsa-mir-20a Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-20a Carcinoma, Colon 26012475 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma. other hsa-mir-20b Carcinoma, Colon 27878272 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer. other hsa-mir-21 Carcinoma, Colon 23827854 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. other hsa-mir-21 Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-21 Carcinoma, Colon 27798874 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. other hsa-mir-21 Carcinoma, Colon 21956205 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 our findings identify direct transcriptional regulation of miR-21 by TCF4 and suggest a role for miR-21 in cancer cell proliferation and invasion upon activation of β-catenin/TCF4 signaling. other hsa-mir-21 Carcinoma, Colon 28560697 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. other hsa-mir-214 Carcinoma, Colon 27537384 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells. other hsa-mir-215 Carcinoma, Colon 24239208 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease. other hsa-mir-29c Carcinoma, Colon 28392396 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. other hsa-mir-301a Carcinoma, Colon 28193514 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. other hsa-mir-302a Carcinoma, Colon 27840990 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells. other hsa-mir-30d Carcinoma, Colon 28651493 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis. other hsa-mir-31 Carcinoma, Colon 27630355 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients. other hsa-mir-34a Carcinoma, Colon 25333573 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil. other hsa-mir-34a Carcinoma, Colon 23991105 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MicroRNA-34a mediates the autocrine signaling of PAR2-activating proteinase and its role in colonic cancer cell proliferation. other hsa-mir-4465 Carcinoma, Colon 27793841 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. other hsa-mir-493 Carcinoma, Colon 24533778 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. other hsa-mir-506 Carcinoma, Colon 26452129 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Taking together, our study sheds light on the role of miR-506 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-506 may serve as a new potential marker for monitoring and treating colon cancer. other hsa-mir-582 Carcinoma, Colon 27595705 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. other hsa-mir-590 Carcinoma, Colon 27878255 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 Roles of mitochondrial transcription factor A and microRNA‑590‑3p in the development of colon cancer. other hsa-mir-598 Carcinoma, Colon 28161537 gastrointestinal system disease DOID:1520 D01.0 C028885 HP:0003003 miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT. other hsa-mir-134 Carcinoma, Embryonal 25447206 disease of cellular proliferation DOID:3308 D018236 HP:0002898 FOXM1 is essential for human pluripotent stem cells and miR-134 attenuates its expression during differentiation. other hsa-mir-140 Carcinoma, Embryonal 26318829 disease of cellular proliferation DOID:3308 D018236 HP:0002898 Role of miR-140 in embryonic bone development and cancer. other hsa-let-7 Carcinoma, Endometrial 27775072 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Metformin acts by upregulating microRNA let-7 through AMPK activation, leading to degradation of H19 long noncoding RNA, which normally binds to and inactivates SAHH other hsa-let-7 Carcinoma, Endometrial 28381177 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Dicer1 dysfunction promotes stemness and aggression in endometrial carcinoma. other hsa-mir-125b Carcinoma, Endometrial 28225751 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Proliferation and migration capability of endometrial carcinoma cells were detected after transfection of endometrial carcinoma cells with mir-125b mimic other hsa-mir-134 Carcinoma, Endometrial 25528443 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 endogenous miR-134 regulation in HuECSCs may suppress tumourigenesis in human endometrial carcinoma. other hsa-mir-143 Carcinoma, Endometrial 24071015 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. other hsa-mir-145 Carcinoma, Endometrial 24589415 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Linc-RoR is a ceRNA and acts as a miR-145 sponge to inhibit mediation of the differentiation of ETs by miR-145. These results suggest that linc-RoR has an important role during endometrial carcinogenesis. other hsa-mir-145 Carcinoma, Endometrial 25634023 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 OCT4-pg5 can act as an RNA sponge to protect OCT4 transcripts from being inhibited by miR-145, providing novel insight into the control of OCT4 expression. other hsa-mir-145 Carcinoma, Endometrial 24071015 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. other hsa-mir-152 Carcinoma, Endometrial 27263284 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Effect of Progesterone-induced MicroRNA-152 on the Proliferation of Endometrial Epithelial Cells. other hsa-mir-203 Carcinoma, Endometrial 29331043 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 Role of miR-203 in estrogen receptor-mediated signaling in the rat uterus and endometrial carcinoma other hsa-mir-203 Carcinoma, Endometrial 21125666 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness other hsa-mir-205 Carcinoma, Endometrial 26817318 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 The role of miRNA in endometrial cancer in the context of miRNA 205 other hsa-mir-22 Carcinoma, Endometrial 24715036 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 miR-22 inhibits proliferation and invasion in estrogen receptor α-positive endometrial endometrioid carcinomas cells. other hsa-mir-23b Carcinoma, Endometrial 21125666 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness other hsa-mir-29c Carcinoma, Endometrial 21125666 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness other hsa-mir-302 Carcinoma, Endometrial 24333727 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 MicroRNA miR-302 inhibits the tumorigenicity of endometrial cancer cells by suppression of Cyclin D1 and CDK1. other hsa-mir-31 Carcinoma, Endometrial 24779718 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 MIR31 functions as an oncogene in endometrial cancer by repressing the Hippo pathway. MIR31 is a potential new molecular marker for predicting the risk of recurrence and prognosis of endometrial cancer. other hsa-mir-93 Carcinoma, Endometrial 27829043 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 MicroRNA-93 Promotes Epithelial-Mesenchymal Transition of Endometrial Carcinoma Cells. other hsa-mir-944 Carcinoma, Endometrial 28178620 reproductive system disease DOID:2871 D07.0 D016889 608089 HP:0012114 miR-944 acts as a prognostic marker and promotes the tumor progression in endometrial cancer. other hsa-mir-186 Carcinoma, Endometrioid Endometrial 23946815 C54.1 D018269 The qRT-PCR analysis further identified a profile of four serum miRNAs (miR-222, miR-223, miR-186 and miR-204) as a fingerprint for EEC detection. other hsa-mir-206 Carcinoma, Endometrioid Endometrial 21983130 C54.1 D018269 Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERж┿positive endometrioid adenocarcinoma. other hsa-let-7g Carcinoma, Esophageal 26655271 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. other hsa-let-7i Carcinoma, Esophageal 26655271 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. other hsa-mir-138 Carcinoma, Esophageal 27536892 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 α-Solanine Modulates the Radiosensitivity of Esophageal Cancer Cells by Inducing MicroRNA 138 Expression. other hsa-mir-144 Carcinoma, Esophageal 24369245 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 miRNA-144 in the saliva is a genetic marker for early diagnosis of esophageal cancer other hsa-mir-144 Carcinoma, Esophageal 27572636 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. other hsa-mir-145 Carcinoma, Esophageal 26156802 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 The effect of recombinant lentiviral vector encoding miR-145 on human esophageal cancer cells. other hsa-mir-193b Carcinoma, Esophageal 26878873 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 These results highlight the importance of miR-193b in determining oesophageal cancer cell viability and demonstrate an enhancement of chemotoxicity that is independent of apoptosis induction. other hsa-mir-196a Carcinoma, Esophageal 27621035 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Inhibition of miR-196a affects esophageal cancer cell growth in vitro. other hsa-mir-200a Carcinoma, Esophageal 28025999 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 miR-200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating cytoplasmic collapsin response mediator protein-1. other hsa-mir-203 Carcinoma, Esophageal 24219349 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1. other hsa-mir-203 Carcinoma, Esophageal 24154605 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells. other hsa-mir-20b Carcinoma, Esophageal 27701465 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 MicroRNA-20b (miR-20b) Promotes the Proliferation, Migration, Invasion, and Tumorigenicity in Esophageal Cancer Cells via the Regulation of Phosphatase and Tensin Homologue Expression. other hsa-mir-21 Carcinoma, Esophageal 26125864 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Association of miR-21 with esophageal cancer prognosis: a meta-analysis. other hsa-mir-21 Carcinoma, Esophageal 26481465 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 In this study, miR-21 was identified as an independent prognostic biomarker for DSS in patients with EAC whereas miR-21 failed to show independent prognostic significance in ESCC. High miR-375 was not associated with enhanced survival in either histology. other hsa-mir-21 Carcinoma, Esophageal 27885434 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. other hsa-mir-212 Carcinoma, Esophageal 25299094 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients. other hsa-mir-27 Carcinoma, Esophageal 26026166 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts. other hsa-mir-30c Carcinoma, Esophageal 26402921 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Factors such as core promoter-binding protein (CPBP), nuclear factor of activated T-cells 1 (NFAT-1), miR-30c-5p, were located in the central hub of this network, highlighting their vital roles in esophageal tumorigenesis. other hsa-mir-374a Carcinoma, Esophageal 26252180 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression. other hsa-mir-375 Carcinoma, Esophageal 26481465 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 In this study, miR-21 was identified as an independent prognostic biomarker for DSS in patients with EAC whereas miR-21 failed to show independent prognostic significance in ESCC. High miR-375 was not associated with enhanced survival in either histology. other hsa-mir-375 Carcinoma, Esophageal 25404787 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker. other hsa-mir-375 Carcinoma, Esophageal 27885434 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. other hsa-mir-451 Carcinoma, Esophageal 27572636 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. other hsa-mir-491 Carcinoma, Esophageal 26279431 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 miR-491 may play a critical role in EC. other hsa-mir-506 Carcinoma, Esophageal 26617801 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Taken together, our data identify a new role of miR-506 in esophageal cancer involving CREB1 suppression. other hsa-mir-93 Carcinoma, Esophageal 28434073 disease of cellular proliferation DOID:1107 C15.9 D004938 133239 HP:0011459 Direct Downregulation of B-Cell Translocation Gene 3 by microRNA-93 Is Required for Desensitizing Esophageal Cancer to Radiotherapy. other hsa-mir-130a Carcinoma, Gallbladder 24953832 disease of cellular proliferation DOID:4948 C23 D005706 Together, these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. other hsa-mir-145 Carcinoma, Gallbladder 24966896 disease of cellular proliferation DOID:4948 C23 D005706 miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. other hsa-mir-19a Carcinoma, Gallbladder 29575299 disease of cellular proliferation DOID:4948 C23 D005706 The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer. other hsa-mir-218 Carcinoma, Gallbladder 25569100 disease of cellular proliferation DOID:4948 C23 D005706 CCAT1 is a driver of malignancy, which acts in part through 'spongeing' miRNA-218-5p. other hsa-let-7a Carcinoma, Gastric 20809749 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo. other hsa-mir-100 Carcinoma, Gastric 28381156 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. other hsa-mir-1284 Carcinoma, Gastric 27627897 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells. other hsa-mir-133b Carcinoma, Gastric 27696637 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1. other hsa-mir-137 Carcinoma, Gastric 25663388 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis. other hsa-mir-148a Carcinoma, Gastric 28381156 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. other hsa-mir-152 Carcinoma, Gastric 28056089 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Helicobacter Pylori Promote B7-H1 Expression by Suppressing miR-152 and miR-200b in Gastric Cancer Cells. other hsa-mir-155 Carcinoma, Gastric 29675003 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers other hsa-mir-190b Carcinoma, Gastric 28044223 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells. other hsa-mir-19a Carcinoma, Gastric 26239140 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of nuclear factor-κB. other hsa-mir-200b Carcinoma, Gastric 28056089 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Helicobacter Pylori Promote B7-H1 Expression by Suppressing miR-152 and miR-200b in Gastric Cancer Cells. other hsa-mir-200c Carcinoma, Gastric 25672630 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 DZNep raises miR-200c expression to delay the invasion and migration of MGC-803 gastric carcinoma cells other hsa-mir-200c Carcinoma, Gastric 28113080 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells. other hsa-mir-204 Carcinoma, Gastric 28133610 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. other hsa-mir-21 Carcinoma, Gastric 28381156 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. other hsa-mir-21 Carcinoma, Gastric 28407783 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. other hsa-mir-22 Carcinoma, Gastric 27662840 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 NTRK2 is an oncogene and associated with microRNA-22 regulation in human gastric cancer cell lines. other hsa-mir-24 Carcinoma, Gastric 27743162 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 miR-24-3p Regulates Progression of Gastric Mucosal Lesions and Suppresses Proliferation and Invasiveness of N87 Via Peroxiredoxin 6. other hsa-mir-29a Carcinoma, Gastric 27000664 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma. other hsa-mir-29b Carcinoma, Gastric 27497248 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Taken together, our results suggested that RUNX3-mediated up-regulation of miR-29b inhibited the proliferation and migration of gastric cancer cells by targeting KDM2A, representing a novel molecular mechanism for the tumor suppression action of RUNX3. other hsa-mir-29c Carcinoma, Gastric 27000664 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma. other hsa-mir-30 Carcinoma, Gastric 27729002 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 miR-30 functions as an oncomiR in gastric cancer cells through regulation of P53-mediated mitochondrial apoptotic pathway. other hsa-mir-30a Carcinoma, Gastric 27876712 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MiR-30a Decreases Multidrug Resistance (MDR) of Gastric Cancer Cells. other hsa-mir-30a Carcinoma, Gastric 28381156 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. other hsa-mir-31 Carcinoma, Gastric 27904131 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MiR-31 Regulates Rho-Associated Kinase-Myosin Light Chain (ROCK-MLC) Pathway and Inhibits Gastric Cancer Invasion other hsa-mir-328 Carcinoma, Gastric 27923017 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Expression of microRNA-328 Functions as a Biomarker for Recurrence of Early Gastric Cancer (EGC) After Endoscopic Submucosal Dissection (ESD) by Modulating CD44. other hsa-mir-340 Carcinoma, Gastric 28057912 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway. other hsa-mir-34a Carcinoma, Gastric 24796666 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a. other hsa-mir-34a Carcinoma, Gastric 29577459 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 abnormal glycolysis was relieved by ASIV via regulation of the expressions of LDHA, p53, TIGAR, MCT1, MCT4, HIF-1α, CD147, and miRNA-34a other hsa-mir-423 Carcinoma, Gastric 28254439 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer. other hsa-mir-429 Carcinoma, Gastric 26513239 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Our data suggest that miR-429 suppression in GC promotes Bcl-2-mediated cancer cell survival against chemotherapy-induced cell death.Re-expression of miR-429 levels in GC cells may enhance cancer apoptosis during chemotherapy. other hsa-mir-449c Carcinoma, Gastric 26141986 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 MiR-449c inhibits gastric carcinoma growth. other hsa-mir-502 Carcinoma, Gastric 27866197 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Rs56288038 (C/G) in 3'UTR of IRF-1 Regulated by MiR-502-5p Promotes Gastric Cancer Development. other hsa-mir-520d Carcinoma, Gastric 28011625 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop. other hsa-mir-574 Carcinoma, Gastric 28042090 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-β1. other hsa-mir-9 Carcinoma, Gastric 28476807 disease of cellular proliferation DOID:5517 C16.9 D013274 HP:0012126 Expression of hsa-miR-9 and MYC Copy Number Variation in Hereditary Diffuse Gastric Cancer. other hsa-mir-141 Carcinoma, Gastrooesophageal 26885979 The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer. other hsa-mir-200c Carcinoma, Gastrooesophageal 26885979 The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer. other hsa-mir-505 Carcinoma, Gastrooesophageal 26885979 The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer. other hsa-mir-99b Carcinoma, Gastrooesophageal 26885979 The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer. other hsa-mir-214 Carcinoma, Gingival 28565877 D00.03 Elucidating the mechanism of miRNA-214 in the regulation of gingival carcinoma. other hsa-let-7 Carcinoma, Hepatocellular 27821157 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway. other hsa-let-7a Carcinoma, Hepatocellular 27693636 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. other hsa-let-7a Carcinoma, Hepatocellular 28691642 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma. other hsa-let-7a Carcinoma, Hepatocellular 28012864 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Germline and somatic DICER1 mutations in familial and sporadic liver tumors. other hsa-let-7b Carcinoma, Hepatocellular 22934260 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. other hsa-let-7b Carcinoma, Hepatocellular 24297460 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. other hsa-let-7c Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-let-7d Carcinoma, Hepatocellular 23682578 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. other hsa-let-7e Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-let-7e Carcinoma, Hepatocellular 23282077 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis. other hsa-let-7f-1 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-let-7f-2 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-let-7g Carcinoma, Hepatocellular 24791593 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Let-7g microRNA sensitizes fluorouracil-resistant human hepatoma cells. other hsa-mir-1 Carcinoma, Hepatocellular 26019452 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-1 might be a potential tumor activator. Inhibiting its expression could decrease proliferation, induce apoptosis, and inhibit the migration and invasion of TECs of human HCC. other hsa-mir-100 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-100 Carcinoma, Hepatocellular 22249248 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression. other hsa-mir-100 Carcinoma, Hepatocellular 27577856 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. other hsa-mir-101 Carcinoma, Hepatocellular 24759835 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels. other hsa-mir-101-1 Carcinoma, Hepatocellular 19155302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101: a tumor suppressor other hsa-mir-101-1 Carcinoma, Hepatocellular 20444294 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101:PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells other hsa-mir-101-1 Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-101-1 Carcinoma, Hepatocellular 22035408 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Benzothiazole based compounds exhibited effective cytotoxicity at 4 M concentration and have shown G1 cell cycle arrest with decrease in levels of G1 cell cycle proteins such as cyclin D1 and Skp2. Involvement of tumour suppressor proteins such as PTEN and p53 was studied. Interestingly these compounds displayed decrease in the phosphorylated forms of AKT, p38 MAPK and ERK1/2 which play a vital role in cell proliferation. Compounds have exhibited strong and significant effect on the expression of micro RNAs such as miR-195a & miR-101-1 which regulate hepatic cell proliferation. other hsa-mir-101-1 Carcinoma, Hepatocellular 23483142 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells other hsa-mir-101-2 Carcinoma, Hepatocellular 19155302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101: a tumor suppressor other hsa-mir-101-2 Carcinoma, Hepatocellular 20444294 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101:PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells other hsa-mir-101-2 Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-101-2 Carcinoma, Hepatocellular 23483142 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells other hsa-mir-103a-1 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-103a-2 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-105 Carcinoma, Hepatocellular 25280563 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. other hsa-mir-106a Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-106a Carcinoma, Hepatocellular 25760076 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells. other hsa-mir-106b Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-106b Carcinoma, Hepatocellular 25327652 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Effects of miR-106b expression on the proliferation of human hepatocellular carcinoma cells. other hsa-mir-106b Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-106b Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-107 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-107 Carcinoma, Hepatocellular 26296971 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miRNA-7/21/108 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. other hsa-mir-107 Carcinoma, Hepatocellular 27571925 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway. other hsa-mir-10a Carcinoma, Hepatocellular 28958640 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression other hsa-mir-10b Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-1180 Carcinoma, Hepatocellular 28468075 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. other hsa-mir-1202 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-122 Carcinoma, Hepatocellular 19296470 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-122: a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma other hsa-mir-122 Carcinoma, Hepatocellular 20527935 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-122:Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma other hsa-mir-122 Carcinoma, Hepatocellular 21917968 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 HepG2 cells expressing miR-122 support the entire hepatitis C virus life cycle. other hsa-mir-122 Carcinoma, Hepatocellular 24130799 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The continued expression of miR-122 in HCV-associated HCC may signify an important role for HCV replication late in the progression to malignancy. other hsa-mir-122 Carcinoma, Hepatocellular 24531873 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Antitumor function of microRNA-122 against hepatocellular carcinoma. other hsa-mir-122 Carcinoma, Hepatocellular 25023326 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Baculovirus-mediated miRNA regulation to suppress hepatocellular carcinoma tumorigenicity and metastasis. other hsa-mir-122 Carcinoma, Hepatocellular 25823567 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma. other hsa-mir-122 Carcinoma, Hepatocellular 25965999 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction. other hsa-mir-122 Carcinoma, Hepatocellular 26179591 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by using Smart Mesoporous Silica Nanoparticles. other hsa-mir-122 Carcinoma, Hepatocellular 26514126 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The findings suggest that the export of miR-122 via AMSC exosomes represents a novel strategy to enhance HCC chemosensitivity. other hsa-mir-122 Carcinoma, Hepatocellular 26655273 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our data imply that an intimate correlation between miR-122 and IGF-1R abnormal expression is a critical determinant of sorafenib tolerance. other hsa-mir-122 Carcinoma, Hepatocellular 25269820 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. other hsa-mir-122 Carcinoma, Hepatocellular 27846390 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. other hsa-mir-122 Carcinoma, Hepatocellular 27895094 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Crosstalk between microRNA-122 and FOX family genes in HepG2 cells. other hsa-mir-122 Carcinoma, Hepatocellular 27980102 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. other hsa-mir-122 Carcinoma, Hepatocellular 28114997 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds. other hsa-mir-122 Carcinoma, Hepatocellular 22820284 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes. other hsa-mir-122 Carcinoma, Hepatocellular 27194671 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 High expression levels of plasma miR-122 are associated with early TACE refractoriness in HCC patients treated with TACE. other hsa-mir-122 Carcinoma, Hepatocellular 27391076 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment. other hsa-mir-122 Carcinoma, Hepatocellular 27450327 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 In this system, we developed a conditionally replicative adenovirus (CRAd) loaded on human umbilical cord-derived mesenchymal stem cells (HUMSCs), in which the CRAd contained an adenovirus E1A gene dual regulated by 伪-fetoprotein promoter and microRNA-122 target sequence. other hsa-mir-122 Carcinoma, Hepatocellular 28179291 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. other hsa-mir-122 Carcinoma, Hepatocellular 28642869 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients. other hsa-mir-122 Carcinoma, Hepatocellular 29534065 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD134+ cells associated with different stages of hepatocarinogensis other hsa-mir-122a Carcinoma, Hepatocellular 28686599 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. other hsa-mir-124 Carcinoma, Hepatocellular 26188282 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma. other hsa-mir-1246 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-1246 Carcinoma, Hepatocellular 27639189 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells. other hsa-mir-1249 Carcinoma, Hepatocellular 28365245 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Induced MiR-1249 expression by aberrant activation of Hedegehog signaling pathway in hepatocellular carcinoma. other hsa-mir-125a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-125a-5p recurence related other hsa-mir-125a Carcinoma, Hepatocellular 27982429 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-125a-5p Is a Downstream Effector of Sorafenib in Its Antiproliferative Activity Toward Human Hepatocellular Carcinoma Cells. other hsa-mir-125a Carcinoma, Hepatocellular 29534065 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD136+ cells associated with different stages of hepatocarinogensis other hsa-mir-125b Carcinoma, Hepatocellular 25889022 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 This finding provides the novel evidence for GLPS on inhibition of HCC through miR-125b inhibiting Tregs accumulation and function. other hsa-mir-125b Carcinoma, Hepatocellular 27577856 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. other hsa-mir-125b Carcinoma, Hepatocellular 28654261 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo. other hsa-mir-125b Carcinoma, Hepatocellular 22824797 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 downregulation of miR-125b was a frequent event in hepatocellular carcinoma (HCC) tissues, and the miR-125b level was positively associated with the rate of apoptosis in HCC tissues. other hsa-mir-125b Carcinoma, Hepatocellular 28521446 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Candidate miRNAs and pathogenesis investigation for hepatocellular carcinoma based on bioinformatics analysis. other hsa-mir-125b Carcinoma, Hepatocellular 28958640 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression other hsa-mir-125b-1 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-125b-1 Carcinoma, Hepatocellular 21703189 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-125b regulates of placenta growth factor in hepatocellular cancer other hsa-mir-125b-1 Carcinoma, Hepatocellular 22942733 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells. other hsa-mir-125b-2 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-125b-2 Carcinoma, Hepatocellular 21703189 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-125b regulates of placenta growth factor in hepatocellular cancer other hsa-mir-125b-2 Carcinoma, Hepatocellular 22942733 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells. other hsa-mir-126 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-126* recurence related other hsa-mir-126 Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-126 Carcinoma, Hepatocellular 25345948 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Expression of miR-126/miR-126* in hepatocelluar carcinoma and its correlation with clinical outcomes. other hsa-mir-1260b Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-1269a Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-127 Carcinoma, Hepatocellular 24854842 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-127 plays a tumor-suppressor role and can serve as a potential diagnostic biomarker for HCC. other hsa-mir-1274a Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-128 Carcinoma, Hepatocellular 25704921 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. other hsa-mir-1290 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-129-1 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-129-5p recurence related other hsa-mir-129-2 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-129-5p recurence related other hsa-mir-1301 Carcinoma, Hepatocellular 22159405 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-1301-mediated inhibition of tumorigenesis. other hsa-mir-130a Carcinoma, Hepatocellular 21712254 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The hepatitis B virus-associated estrogen receptor alpha (ER{alpha}) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells. other hsa-mir-130b Carcinoma, Hepatocellular 25387077 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome proliferator-activated receptor gamma in human hepatocellular carcinoma. other hsa-mir-133a Carcinoma, Hepatocellular 25714665 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 These findings for the first time demonstrated that the involvement of miR-133a and miR-326 in MDR is mediated by ABCC1 in hepatocellular carcinoma cell line HepG2 and suggested that miR-133a and miR-326 may be efficient agents for preventing and reversing ADM resistance in cancer cells. other hsa-mir-137 Carcinoma, Hepatocellular 26352279 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42. other hsa-mir-138 Carcinoma, Hepatocellular 28258280 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression. other hsa-mir-140 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-140-3p recurence related other hsa-mir-141 Carcinoma, Hepatocellular 20619223 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-141:Hsa-miR-141 and hsa-miR-200c, microRNAs that promote epithelial phenotypes, had significantly higher levels in non-hepatic epithelial tumors other hsa-mir-141 Carcinoma, Hepatocellular 24135722 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec24a-mediated secretome. other hsa-mir-141 Carcinoma, Hepatocellular 25425543 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-141 functions as a tumor suppressor in HCC cells through the inhibition of HNF-3β translation. other hsa-mir-142 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-142-3p recurence related other hsa-mir-142 Carcinoma, Hepatocellular 25292173 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 This study reveals a novel role for propofol in the inhibition of HCC through MV-mediated transfer of miR-142-3p from macrophages to cancer cells in vivo. other hsa-mir-142 Carcinoma, Hepatocellular 28243631 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies. other hsa-mir-145 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-145 Carcinoma, Hepatocellular 22378186 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. other hsa-mir-145 Carcinoma, Hepatocellular 22431718 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. other hsa-mir-145 Carcinoma, Hepatocellular 24630966 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-145: a promising biomarker for hepatocellular carcinoma (HCC). other hsa-mir-146a Carcinoma, Hepatocellular 21982769 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-146a suppresses the sensitivity to interferon-a in hepatocellular carcinoma cells. other hsa-mir-146a Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-146a Carcinoma, Hepatocellular 24895573 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. other hsa-mir-146b Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-147a Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-148a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-148a Carcinoma, Hepatocellular 23861222 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma. other hsa-mir-148a Carcinoma, Hepatocellular 24806207 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells. other hsa-mir-148a Carcinoma, Hepatocellular 28958640 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression other hsa-mir-149 Carcinoma, Hepatocellular 28468075 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. other hsa-mir-150 Carcinoma, Hepatocellular 26215970 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-150: a promising novel biomarker for hepatitis B virus-related hepatocellular carcinoma. other hsa-mir-150 Carcinoma, Hepatocellular 25549355 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 re-expression of MMP14 in hepatoma cells partially reverses the effect of miR-150-5p in inhibiting cell invasion other hsa-mir-151 Carcinoma, Hepatocellular 20812359 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma. other hsa-mir-152 Carcinoma, Hepatocellular 28339081 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinoma. other hsa-mir-153 Carcinoma, Hepatocellular 25708809 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX. other hsa-mir-155 Carcinoma, Hepatocellular 23316018 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 These results suggest that S100A4 exerts its effects through the regulation of miR-155 expression in HCC cells other hsa-mir-155 Carcinoma, Hepatocellular 27913196 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis. other hsa-mir-155 Carcinoma, Hepatocellular 28670383 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-155 up-regulated by TGF-β promotes epithelial-mesenchymal transition, invasion and metastasis of human hepatocellular carcinoma cells in vitro. other hsa-mir-15a Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-15a Carcinoma, Hepatocellular 23649629 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. other hsa-mir-15b Carcinoma, Hepatocellular 26023735 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A. other hsa-mir-16 Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-16 Carcinoma, Hepatocellular 24759835 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels. other hsa-mir-16 Carcinoma, Hepatocellular 23282077 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis. other hsa-mir-16 Carcinoma, Hepatocellular 28770611 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Clinical significance of miRNA-autophagy transcript expression in patients with hepatocellular carcinoma other hsa-mir-16 Carcinoma, Hepatocellular 29136911 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-155 expression, essential in NK cell activation, was elevated in Foxo3-/- NK cells while its inhibition led to diminished IFNγ production other hsa-mir-16 Carcinoma, Hepatocellular 29344256 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR-16 expression other hsa-mir-16-1 Carcinoma, Hepatocellular 21336967 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. other hsa-mir-16-1 Carcinoma, Hepatocellular 23649629 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. other hsa-mir-16-2 Carcinoma, Hepatocellular 21336967 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. other hsa-mir-17 Carcinoma, Hepatocellular 24297460 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. other hsa-mir-17 Carcinoma, Hepatocellular 23912452 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells. other hsa-mir-17 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-17 Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-17 Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-17 Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-17 Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-17 Carcinoma, Hepatocellular 26804174 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 SLU7 knockdown altered the splicing of the C13orf25 primary transcript, and markedly reduced the expression of its miR-17, miR-20 and miR-92a constituents. other hsa-mir-17 Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-18 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-18 Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-18 Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-18 Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-18 Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-18 Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-181a-2 Carcinoma, Hepatocellular 20576283 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miRNA-181a:Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines other hsa-mir-181b Carcinoma, Hepatocellular 29534065 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD135+ cells associated with different stages of hepatocarinogensis other hsa-mir-181d Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-182 Carcinoma, Hepatocellular 25739014 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5p and miR-182-5p on insulin-like growth factor II, insulin-like growth factor-1 receptor and insulin-like growth factor-binding protein-3 in hepatocellular carcinoma. other hsa-mir-182 Carcinoma, Hepatocellular 26126858 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis. other hsa-mir-182 Carcinoma, Hepatocellular 27262453 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Upon forcing miR-182 expression in the HCC NK-cells, upregulation of both receptors was observed. other hsa-mir-183 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-183 Carcinoma, Hepatocellular 24222732 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Expression and significance of microRNA-183 in hepatocellular carcinoma. other hsa-mir-183 Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-183 Carcinoma, Hepatocellular 26188282 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma. other hsa-mir-183 Carcinoma, Hepatocellular 26400524 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 This study revealed a novel miR-21/miR-183-SOCS7 axis that might play an important role in modulating cell growth and invasion of HCC cells. other hsa-mir-184 Carcinoma, Hepatocellular 24183204 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-184 functions as an oncogenic regulator in hepatocellular carcinoma (HCC). other hsa-mir-185 Carcinoma, Hepatocellular 28240051 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-185 induces potent autophagy via AKT signaling in hepatocellular carcinoma. other hsa-mir-18a Carcinoma, Hepatocellular 19027010 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-18a: prevents estrogen receptor-alpha expression, promoting proliferation other hsa-mir-18a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-18a Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-18a Carcinoma, Hepatocellular 24975878 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma. other hsa-mir-18a Carcinoma, Hepatocellular 28219903 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. other hsa-mir-18a Carcinoma, Hepatocellular 23682578 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. other hsa-mir-18a Carcinoma, Hepatocellular 28302149 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis. other hsa-mir-18b Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-18b Carcinoma, Hepatocellular 21876625 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 potential associated miRNA other hsa-mir-190a Carcinoma, Hepatocellular 26608035 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our results reveal the involvement of miR-190a-treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis. other hsa-mir-190b Carcinoma, Hepatocellular 24586785 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Increased expression of miR-190 may cause decreased IGF-1 in HCC development. Insulin resistance appears to be a part of the physiopathologic significance of decreased IGF-1 levels in HCC progression. This study provides a novel miRNA-mediated regulatory mechanism for controlling IGF-1 expression in HCC and elucidates the biological relevance of this interaction in HCC. other hsa-mir-191 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-191 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-192 Carcinoma, Hepatocellular 22433310 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 HBx gene down-regulates miR-192 expression and inhibits apoptosis of human hepatoma cell line HepG2. other hsa-mir-192 Carcinoma, Hepatocellular 28465351 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function. other hsa-mir-192 Carcinoma, Hepatocellular 29534065 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD133+ cells associated with different stages of hepatocarinogensis other hsa-mir-193a Carcinoma, Hepatocellular 24330766 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Effects of miR-193a and sorafenib on hepatocellular carcinoma cells. other hsa-mir-193b Carcinoma, Hepatocellular 25034398 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Modulation of miRNAs expression might be a potential way to enhance response to sorafenib in HBV-associated HCC. other hsa-mir-193b Carcinoma, Hepatocellular 25997995 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-193b acts as a cisplatin sensitizer via the caspase-3-dependent pathway in HCC chemotherapy. other hsa-mir-194 Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-194 Carcinoma, Hepatocellular 28465351 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function. other hsa-mir-195 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-196a-1 Carcinoma, Hepatocellular 20127796 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-196:MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression other hsa-mir-196a-2 Carcinoma, Hepatocellular 20127796 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-196:MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression other hsa-mir-198 Carcinoma, Hepatocellular 23391410 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration other hsa-mir-199a Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-199a Carcinoma, Hepatocellular 25714015 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents. other hsa-mir-199a Carcinoma, Hepatocellular 28529584 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. other hsa-mir-199a-1 Carcinoma, Hepatocellular 23742776 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression. other hsa-mir-199a-2 Carcinoma, Hepatocellular 23742776 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression. other hsa-mir-199b Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-19a Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-19a Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-19a Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-19a Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-19a Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-19a Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-19a Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-19b-1 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-19b-1 Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-19b-1 Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-19b-1 Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-19b-1 Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-19b-1 Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-200 Carcinoma, Hepatocellular 23857252 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC). other hsa-mir-200 Carcinoma, Hepatocellular 24135722 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec23a-mediated secretome. other hsa-mir-200a Carcinoma, Hepatocellular 22868917 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers. other hsa-mir-200a Carcinoma, Hepatocellular 23760980 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells. other hsa-mir-200a Carcinoma, Hepatocellular 25482402 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation. other hsa-mir-200a Carcinoma, Hepatocellular 25797260 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2. other hsa-mir-200b Carcinoma, Hepatocellular 22868917 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers. other hsa-mir-200b Carcinoma, Hepatocellular 23760980 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells. other hsa-mir-200c Carcinoma, Hepatocellular 20619223 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-200c:Hsa-miR-141 and hsa-miR-200c, microRNAs that promote epithelial phenotypes, had significantly higher levels in non-hepatic epithelial tumors other hsa-mir-200c Carcinoma, Hepatocellular 24135722 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec25a-mediated secretome. other hsa-mir-203 Carcinoma, Hepatocellular 21786180 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver. other hsa-mir-203 Carcinoma, Hepatocellular 28100026 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. other hsa-mir-203a Carcinoma, Hepatocellular 26210453 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of miRNA-30c and miR-204a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells. other hsa-mir-204 Carcinoma, Hepatocellular 23282077 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis. other hsa-mir-20a Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-20a Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-20a Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-20a Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-20a Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-20a Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-21 Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-mir-21 Carcinoma, Hepatocellular 20447717 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-21:MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma other hsa-mir-21 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-21 Carcinoma, Hepatocellular 23442323 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma other hsa-mir-21 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-21 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-21 Carcinoma, Hepatocellular 24759835 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels. other hsa-mir-21 Carcinoma, Hepatocellular 24845419 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor β and androgen receptor. other hsa-mir-21 Carcinoma, Hepatocellular 25447674 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 I3C could function as a miR-21 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC. other hsa-mir-21 Carcinoma, Hepatocellular 25720799 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity. other hsa-mir-21 Carcinoma, Hepatocellular 26296971 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miRNA-7/21/109 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. other hsa-mir-21 Carcinoma, Hepatocellular 26400524 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 This study revealed a novel miR-21/miR-183-SOCS6 axis that might play an important role in modulating cell growth and invasion of HCC cells. other hsa-mir-21 Carcinoma, Hepatocellular 24112539 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3. other hsa-mir-21 Carcinoma, Hepatocellular 26060089 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression. other hsa-mir-21 Carcinoma, Hepatocellular 25969534 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. other hsa-mir-21 Carcinoma, Hepatocellular 29538313 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our analysis identified novel miR-21 targets that are likely to play a causal role in hepatocarcinogenesis other hsa-mir-21 Carcinoma, Hepatocellular 28529584 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. other hsa-mir-210 Carcinoma, Hepatocellular 27018975 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Down-regulation of TIMP2 by HIF-1伪/miR-210/HIF-3伪 regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma. other hsa-mir-214 Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-214 Carcinoma, Hepatocellular 23962428 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis. other hsa-mir-214 Carcinoma, Hepatocellular 24719559 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Addition of NCTD to treat RAW264.7 or TAMs enhanced M1 polarization through increase of miR-214 expression. NCTD significantly inhibited 尾-catenin expression, which could be reversed by miR-214 inhibitor. other hsa-mir-215 Carcinoma, Hepatocellular 28958640 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression other hsa-mir-216 Carcinoma, Hepatocellular 20206398 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We also found an inverse correlation between IGF activation and miR-100/miR-216 levels (FDR<0.05). other hsa-mir-216b Carcinoma, Hepatocellular 25741595 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway. other hsa-mir-218 Carcinoma, Hepatocellular 25110121 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. other hsa-mir-218 Carcinoma, Hepatocellular 25120782 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-218 modulate hepatocellular carcinoma cell proliferation through PTEN/AKT/PI3K pathway and HoxA10. other hsa-mir-218 Carcinoma, Hepatocellular 26024833 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC. other hsa-mir-22 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-22 Carcinoma, Hepatocellular 21750200 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-22 promotes HBV related hepatocellular carcinoma development in males. other hsa-mir-221 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-221 Carcinoma, Hepatocellular 25447674 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 I3C could function as a miR-19 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC. other hsa-mir-221 Carcinoma, Hepatocellular 27904678 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NFκB. other hsa-mir-221 Carcinoma, Hepatocellular 27983537 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma. other hsa-mir-221 Carcinoma, Hepatocellular 28096271 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis. other hsa-mir-221 Carcinoma, Hepatocellular 28302149 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis. other hsa-mir-221 Carcinoma, Hepatocellular 29322790 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-221 and miR-222 might affect the pathogenesis of HCC other hsa-mir-221 Carcinoma, Hepatocellular 28529584 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. other hsa-mir-222 Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-mir-222 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-222 Carcinoma, Hepatocellular 25447674 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 I3C could function as a miR-20 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC. other hsa-mir-222 Carcinoma, Hepatocellular 29322790 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-221 and miR-223 might affect the pathogenesis of HCC other hsa-mir-223 Carcinoma, Hepatocellular 18555017 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-223: MicroRNA-223 is commonly reproessed in hepatocellular carcinoma and potentiates expression of Stathmin1 other hsa-mir-223 Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-223 Carcinoma, Hepatocellular 27998765 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation. other hsa-mir-224 Carcinoma, Hepatocellular 23741247 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-224 functions as an onco-miRNA in hepatocellular carcinoma cells by activating AKT signaling. other hsa-mir-224 Carcinoma, Hepatocellular 23913306 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A noncanonical pathway links autophagy,miR-224, Smad4, and HBV-associated HCC. These findings open a new avenue for the treatment of HCC. other hsa-mir-23a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-23a Carcinoma, Hepatocellular 24417970 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Correlation between miR-23a and onset of hepatocellular carcinoma. other hsa-mir-23a Carcinoma, Hepatocellular 26305257 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 up-regulating the expression of miR-23a may activate the positive regulatory network of p53 and miR-23a involved in the mechanism underlying the anti-tumor effect of berberine in hepatocellular carcinoma (HCC). other hsa-mir-23a Carcinoma, Hepatocellular 18508316 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. other hsa-mir-24 Carcinoma, Hepatocellular 24800232 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-24 modulates aflatoxin B1-related hepatocellular carcinoma prognosis and tumorigenesis. other hsa-mir-24 Carcinoma, Hepatocellular 18508316 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. other hsa-mir-24-1 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-24-1 Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-24-2 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-24-2 Carcinoma, Hepatocellular 22552153 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurrence-related in hepatocellular carcinoma other hsa-mir-25 Carcinoma, Hepatocellular 27840896 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway. other hsa-mir-26 Carcinoma, Hepatocellular 23569435 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Development of a miR-26 Companion Diagnostic Test for Adjuvant Interferon-alpha Therapy in Hepatocellular Carcinoma other hsa-mir-26a Carcinoma, Hepatocellular 24296580 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hepatocellular carcinoma: New insight into angiogenesis in hepatocellular carcinoma: involvement of microRNA-26a. other hsa-mir-26a Carcinoma, Hepatocellular 27906498 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway. other hsa-mir-26a Carcinoma, Hepatocellular 28079894 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy. other hsa-mir-26a-1 Carcinoma, Hepatocellular 21610700 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Tumor-specific Expression of MicroRNA-26a Suppresses Human Hepatocellular Carcinoma Growth via Cyclin-dependent and -independent Pathways. other hsa-mir-26a-2 Carcinoma, Hepatocellular 21610700 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Tumor-specific Expression of MicroRNA-26a Suppresses Human Hepatocellular Carcinoma Growth via Cyclin-dependent and -independent Pathways. other hsa-mir-27a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-27a Carcinoma, Hepatocellular 18508316 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. other hsa-mir-27b Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-27b Carcinoma, Hepatocellular 24614526 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Fumonisin B modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. other hsa-mir-29 Carcinoma, Hepatocellular 24798303 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Modulation of miR-29 expression by α-fetoprotein is linked to the hepatocellular carcinoma epigenome. other hsa-mir-29 Carcinoma, Hepatocellular 25367851 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Negative feedback of miR-29 family TET1 involves in hepatocellular cancer. other hsa-mir-29a Carcinoma, Hepatocellular 23023935 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our findings demonstrate that the expression of miR-29a is important in the regulation of the SPARC-AKT pathway and HCC growth. other hsa-mir-302c Carcinoma, Hepatocellular 25027009 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells. other hsa-mir-30a Carcinoma, Hepatocellular 25654285 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Effect of miR-30a-5p on the proliferation, apoptosis, invasion and migration of SMCC-7721 human hepatocellular carcinoma cells other hsa-mir-30a Carcinoma, Hepatocellular 23282077 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis. other hsa-mir-30a Carcinoma, Hepatocellular 28732393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-30a suppresses tumor progression by blocking Ras/Raf/MEK/ERK signaling pathway in hepatocellular carcinoma other hsa-mir-30a Carcinoma, Hepatocellular 29061507 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma. other hsa-mir-30b Carcinoma, Hepatocellular 24314246 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC. other hsa-mir-30b Carcinoma, Hepatocellular 27894814 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells. other hsa-mir-30c Carcinoma, Hepatocellular 26210453 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells. other hsa-mir-30d Carcinoma, Hepatocellular 27571925 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway. other hsa-mir-30e Carcinoma, Hepatocellular 28958640 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression other hsa-mir-31 Carcinoma, Hepatocellular 27909734 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Klf4 inhibits tumor growth and metastasis by targeting microRNA-31 in human hepatocellular carcinoma. other hsa-mir-3144 Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-3178 Carcinoma, Hepatocellular 26182877 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Regulation of tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells by microRNA-3178 and underlying mechanism. other hsa-mir-326 Carcinoma, Hepatocellular 25714665 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 These findings for the first time demonstrated that the involvement of miR-133a and miR-326 in MDR is mediated by ABCC1 in hepatocellular carcinoma cell line HepG2 and suggested that miR-133a and miR-326 may be efficient agents for preventing and reversing ADM resistance in cancer cells. other hsa-mir-328 Carcinoma, Hepatocellular 23682578 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. other hsa-mir-331 Carcinoma, Hepatocellular 25750939 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 This provided useful information in exploring the mechanism of HCC induced by HBV infection. other hsa-mir-338 Carcinoma, Hepatocellular 26315112 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma. other hsa-mir-338 Carcinoma, Hepatocellular 26060089 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression. other hsa-mir-338 Carcinoma, Hepatocellular 27694002 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Down-regulation of microRNA-338-3p promoted angiogenesis in hepatocellular carcinoma. other hsa-mir-345 Carcinoma, Hepatocellular 23577194 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hepatitis C Virus Core Protein Down-Regulates p21(Waf1/Cip1) and Inhibits Curcumin-Induced Apoptosis through MicroRNA-345 Targeting in Human Hepatoma Cells other hsa-mir-34a Carcinoma, Hepatocellular 19006648 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-34a: miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells other hsa-mir-34a Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-mir-34a Carcinoma, Hepatocellular 25596083 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the expression of miR-34a in HCC biopsy specimens has an independent predictive value of early recurrence after RFA. other hsa-mir-34a Carcinoma, Hepatocellular 26060089 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression. other hsa-mir-34a Carcinoma, Hepatocellular 27725225 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells. other hsa-mir-34a Carcinoma, Hepatocellular 28356025 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Regulation of Apoptosis by SYB in HepG2 Liver Cancer Cells is Mediated by the P53/Caspase 9 Axis. other hsa-mir-34a Carcinoma, Hepatocellular 29128099 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury. other hsa-mir-362 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-362-3p recurence related other hsa-mir-365 Carcinoma, Hepatocellular 25973057 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma. other hsa-mir-365 Carcinoma, Hepatocellular 28184920 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-365 targets ADAM10 and suppresses the cell growth and metastasis of hepatocellular carcinoma. other hsa-mir-367 Carcinoma, Hepatocellular 27688096 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals. other hsa-mir-379 Carcinoma, Hepatocellular 28051262 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatic identification of IGF1 as a hub gene in hepatocellular carcinoma (HCC) and in-vitro analysis of the chemosensitizing effect of miR-379 via suppressing the IGF1/IGF1R signaling pathway. other hsa-mir-375 Carcinoma, Hepatocellular 28577837 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma. other hsa-mir-375 Carcinoma, Hepatocellular 28769563 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma other hsa-mir-375 Carcinoma, Hepatocellular 28915706 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The role of autophagy in hepatocellular carcinoma: friend or foe. other hsa-mir-375 Carcinoma, Hepatocellular 29555460 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-375/Sf-LCC NPs can deliver sorafenib and miR-375 into HCC cells and tumor tissues, increase drug retention time in tumor, significantly inhibit autophagy and produce enhanced anti-tumor effect other hsa-mir-376a-1 Carcinoma, Hepatocellular 22684007 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma. other hsa-mir-376a-2 Carcinoma, Hepatocellular 22684007 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma. other hsa-mir-378a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-379 Carcinoma, Hepatocellular 27266355 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Effects of microRNA-379-5p on proliferation, migration and invasion of hepatocellular carcinoma cell line. other hsa-mir-421 Carcinoma, Hepatocellular 22446874 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of Human Farnesoid X Receptor by miR-421 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells. other hsa-mir-423 Carcinoma, Hepatocellular 26663009 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR423-5p contributed to the tumorigenesis and progression of HCC.It could be a new predictor in HCC patients beyond the Milan criteria and would help to improve patient outcomes and enlarge recipient pools of liver transplantation. other hsa-mir-424 Carcinoma, Hepatocellular 26315541 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma. other hsa-mir-425 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-429 Carcinoma, Hepatocellular 25931210 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 our results here defined miR-429 as a key inducer for HCC pathogenesis and metastasis with potential utility for tumor intervention. other hsa-mir-432 Carcinoma, Hepatocellular 25797263 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation. other hsa-mir-451 Carcinoma, Hepatocellular 26164082 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma. other hsa-mir-451 Carcinoma, Hepatocellular 24841638 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-451: potential role as tumor suppressor of human hepatoma cell growth and invasion. other hsa-mir-483 Carcinoma, Hepatocellular 24127413 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Exploration of genome-wide circulating microRNA in hepatocellular carcinoma:MiR-483-5p as a potential biomarker. other hsa-mir-490 Carcinoma, Hepatocellular 24875649 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. other hsa-mir-491 Carcinoma, Hepatocellular 23725476 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition. other hsa-mir-497 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-499a Carcinoma, Hepatocellular 22641068 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells. other hsa-mir-499b Carcinoma, Hepatocellular 22641068 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells. other hsa-mir-500 Carcinoma, Hepatocellular 19863192 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our findings reveal that diverse changes of miRNAs occur during liver development and, one of these, miR-500 is an oncofetal miRNA relevant to the diagnosis of human HCC. other hsa-mir-500a Carcinoma, Hepatocellular 19737067 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 oncofetal miRNA relevant to the diagnosis other hsa-mir-502 Carcinoma, Hepatocellular 26163264 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma. other hsa-mir-503 Carcinoma, Hepatocellular 21495032 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-503 regulates metastatic function in hepatocellular cancer cell. other hsa-mir-503 Carcinoma, Hepatocellular 23967867 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our data highlight an important role for miR-503 in cell cycle regulation and in the molecular etiology of HCC, and implicate the potential application of miR-503 in prognosis prediction and miRNA-based HCC therapy. other hsa-mir-508 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-520d Carcinoma, Hepatocellular 24458129 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process. other hsa-mir-520e Carcinoma, Hepatocellular 22212428 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. other hsa-mir-539 Carcinoma, Hepatocellular 27717846 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma. other hsa-mir-573 Carcinoma, Hepatocellular 26201458 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The miR-573/apoM/Bcl2A1-dependent signal transduction pathway is essential for hepatocyte apoptosis and hepatocarcinogenesis. other hsa-mir-581 Carcinoma, Hepatocellular 24913918 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development. other hsa-mir-612 Carcinoma, Hepatocellular 23478189 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma other hsa-mir-630 Carcinoma, Hepatocellular 25731670 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator. other hsa-mir-637 Carcinoma, Hepatocellular 21809363 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Primate-specific miRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting stat3 signaling. other hsa-mir-675 Carcinoma, Hepatocellular 24939300 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 inhibition of LncRNAH19 and miR-675 expression can promote migration and invasion of HCC cells via AKT/GSK-3β/Cdc25A signaling pathway. other hsa-mir-7 Carcinoma, Hepatocellular 24339204 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells. other hsa-mir-7 Carcinoma, Hepatocellular 26296971 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. other hsa-mir-7 Carcinoma, Hepatocellular 27519414 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Suppression of MicroRNA-7 (miR-7) Biogenesis by Nuclear Factor 90-Nuclear Factor 45 Complex (NF90-NF45) Controls Cell Proliferation in Hepatocellular Carcinoma. other hsa-mir-7 Carcinoma, Hepatocellular 27614453 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. other hsa-mir-7 Carcinoma, Hepatocellular 28459371 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma. other hsa-mir-744 Carcinoma, Hepatocellular 28468075 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. other hsa-mir-877 Carcinoma, Hepatocellular 24060847 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. other hsa-mir-9 Carcinoma, Hepatocellular 26206264 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 this study revealed the involvement of the miR-9/PPARA/CDH1 signaling pathway in HCC oncogenesis. other hsa-mir-9 Carcinoma, Hepatocellular 25552204 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 the potential of miR-9 as a novel prognostic biomarker for HCC. Large well-designed studies with diverse populations and functional evaluations are warranted to confirm and extend our findings. other hsa-mir-9 Carcinoma, Hepatocellular 28062574 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma. other hsa-mir-92 Carcinoma, Hepatocellular 23546593 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Expression and significance of PTEN and miR-92 in hepatocellular carcinoma other hsa-mir-92-1 Carcinoma, Hepatocellular 24358224 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. other hsa-mir-92-1 Carcinoma, Hepatocellular 24876719 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. other hsa-mir-92-1 Carcinoma, Hepatocellular 26231474 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-95 cluster promotes hepatocarcinogenesis. other hsa-mir-92-1 Carcinoma, Hepatocellular 26232302 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-94 cluster promotes hepatocarcinogenesis. other hsa-mir-92-1 Carcinoma, Hepatocellular 26233130 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-17-93 cluster promotes hepatocarcinogenesis. other hsa-mir-92-1 Carcinoma, Hepatocellular 28904393 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. other hsa-mir-92a Carcinoma, Hepatocellular 26804174 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 SLU7 knockdown altered the splicing of the C13orf25 primary transcript, and markedly reduced the expression of its miR-17, miR-20 and miR-92a constituents. other hsa-mir-93 Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-mir-93 Carcinoma, Hepatocellular 22773266 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Downregulation of MiR-93 Expression Reduces Cell Proliferation and Clonogenicity of HepG2 Cells. other hsa-mir-940 Carcinoma, Hepatocellular 25940592 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 MiR-940 inhibits hepatocellular carcinoma growth and correlates with prognosis of hepatocellular carcinoma patients. other hsa-mir-940 Carcinoma, Hepatocellular 28468075 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. other hsa-mir-941 Carcinoma, Hepatocellular 25049231 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 miR-941 and KDM6B regulated the epithelial-mesenchymal transition process and affected cell migratory/invasive properties. other hsa-mir-95 Carcinoma, Hepatocellular 24530415 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma. other hsa-mir-96 Carcinoma, Hepatocellular 20018759 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC other hsa-mir-96 Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-96 Carcinoma, Hepatocellular 22160187 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Suppression of microRNA-96 expression inhibits the invasion of hepatocellular carcinoma cells. other hsa-mir-96 Carcinoma, Hepatocellular 23151657 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells other hsa-mir-99a Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-99a Carcinoma, Hepatocellular 26060089 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression. other hsa-mir-99b Carcinoma, Hepatocellular 21298008 disease of cellular proliferation DOID:684 C22.0 D006528 114550 HP:0001402 recurence related other hsa-mir-101 Carcinoma, Hepatocellular, HBV-Related 24697700 Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis. other hsa-mir-122 Carcinoma, Hepatocellular, HBV-Related 24748463 Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk. other hsa-mir-429 Carcinoma, Hepatocellular, HBV-Related 25312821 miR-429 represses cell proliferation and induces apoptosis in HBV-related HCC. other hsa-mir-602 Carcinoma, Hepatocellular, HBV-Related 24398562 Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes. other hsa-mir-122 Carcinoma, Hepatocellular, HCV-Related 24690114 Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma. other hsa-let-7 Carcinoma, Laryngeal 27874955 disease of cellular proliferation DOID:2600 C32.3 D007822 21198 HP:0012118 Expression and significances of MiRNA Let-7 and HMGA2 in laryngeal carcinoma. other hsa-mir-106b Carcinoma, Laryngeal 23912048 disease of cellular proliferation DOID:2600 C32.3 D007822 21198 HP:0012118 MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells. other hsa-mir-152 Carcinoma, Laryngeal 25095980 disease of cellular proliferation DOID:2600 C32.3 D007822 21198 HP:0012118 Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma. other hsa-mir-27a Carcinoma, Laryngeal 28122350 disease of cellular proliferation DOID:2600 C32.3 D007822 21198 HP:0012118 Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway. other hsa-mir-423 Carcinoma, Laryngeal 25337209 disease of cellular proliferation DOID:2600 C32.3 D007822 21198 HP:0012118 microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma. other hsa-mir-1 Carcinoma, Lung 27541266 disease of cellular proliferation DOID:3905 C34.90 D008175 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. other hsa-mir-127 Carcinoma, Lung 27869168 disease of cellular proliferation DOID:3905 C34.90 D008175 miR-127 promotes EMT and stem-like traits in lung cancer through a feed-forward regulatory loop. other hsa-mir-129b Carcinoma, Lung 27813559 disease of cellular proliferation DOID:3905 C34.90 D008175 miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299. other hsa-mir-146a Carcinoma, Lung 27463381 disease of cellular proliferation DOID:3905 C34.90 D008175 Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-155 Carcinoma, Lung 27463381 disease of cellular proliferation DOID:3905 C34.90 D008175 Chitin also induced the expression of the key pattern recognition receptors TLR2 and TLR4. Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-155 Carcinoma, Lung 28400205 disease of cellular proliferation DOID:3905 C34.90 D008175 Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles. other hsa-mir-200 Carcinoma, Lung 27694892 disease of cellular proliferation DOID:3905 C34.90 D008175 ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. other hsa-mir-200 Carcinoma, Lung 27189341 disease of cellular proliferation DOID:3905 C34.90 D008175 AKT2 can regulate miR-200a in a histology- or stage-specific manner other hsa-mir-200a Carcinoma, Lung 27189341 disease of cellular proliferation DOID:3905 C34.90 D008175 AKT2 can regulate miR-200a in a histology- or stage-specific manner and that other hsa-mir-203 Carcinoma, Lung 26132195 disease of cellular proliferation DOID:3905 C34.90 D008175 miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells. other hsa-mir-206 Carcinoma, Lung 24189536 disease of cellular proliferation DOID:3905 C34.90 D008175 miR-206 is capable of suppressing a known oncogene, it might be a true tumor suppressor gene and, as such, be deleted, modified, or directly repressed in human tumors. other hsa-mir-206 Carcinoma, Lung 27541266 disease of cellular proliferation DOID:3905 C34.90 D008175 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. other hsa-mir-21 Carcinoma, Lung 24004609 disease of cellular proliferation DOID:3905 C34.90 D008175 Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells. other hsa-mir-21 Carcinoma, Lung 27463381 disease of cellular proliferation DOID:3905 C34.90 D008175 Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines. other hsa-mir-21 Carcinoma, Lung 28283413 disease of cellular proliferation DOID:3905 C34.90 D008175 Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. other hsa-mir-21 Carcinoma, Lung 28705115 disease of cellular proliferation DOID:3905 C34.90 D008175 MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact. other hsa-mir-214 Carcinoma, Lung 27642589 disease of cellular proliferation DOID:3905 C34.90 D008175 cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/β-catenin signaling other hsa-mir-222 Carcinoma, Lung 27566197 disease of cellular proliferation DOID:3905 C34.90 D008175 Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. other hsa-mir-223 Carcinoma, Lung 28281961 disease of cellular proliferation DOID:3905 C34.90 D008175 MicroRNA-223 Promotes Tumor Progression in Lung Cancer A549 Cells via Activation of the NF-κB Signaling Pathway. other hsa-mir-30a Carcinoma, Lung 28400205 disease of cellular proliferation DOID:3905 C34.90 D008175 Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles. other hsa-mir-31 Carcinoma, Lung 27541266 disease of cellular proliferation DOID:3905 C34.90 D008175 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. other hsa-mir-34 Carcinoma, Lung 28705115 disease of cellular proliferation DOID:3905 C34.90 D008175 MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact. other hsa-mir-495 Carcinoma, Lung 25286762 disease of cellular proliferation DOID:3905 C34.90 D008175 MicroRNA-495 mimics delivery inhibits lung tumor progression. other hsa-mir-558 Carcinoma, Lung 27485693 disease of cellular proliferation DOID:3905 C34.90 D008175 By contrast, in the cells exposed to 4, 6 or 8 Gy, the administration of miR鈥?58 mimics or AATK specific siRNA significantly promoted cell survival rate and overexpression of AATK reversed this effect. other hsa-mir-616 Carcinoma, Lung 27890917 disease of cellular proliferation DOID:3905 C34.90 D008175 Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. other hsa-mir-7 Carcinoma, Lung 27642589 disease of cellular proliferation DOID:3905 C34.90 D008175 cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/β-catenin signaling other hsa-let-7a Carcinoma, Lung, Non-Small-Cell 23349018 C34.90 D002289 HP:0030358 Expression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples. other hsa-let-7c Carcinoma, Lung, Non-Small-Cell 24400442 C34.90 D002289 HP:0030358 Modulation of let-7c altered the sensitivity of A549/DDP cells to DDP through regulating DDP-induced apopotis. other hsa-mir-1 Carcinoma, Lung, Non-Small-Cell 23617628 C34.90 D002289 HP:0030358 Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis. other hsa-mir-125a Carcinoma, Lung, Non-Small-Cell 20719190 C34.90 D002289 HP:0030358 hsa-miR-125a-5p was poorly-expressed in lung cancer cells and it could enhance lung cancer cell invasion by up-regulating hsa-miR-125a-5p. other hsa-mir-143 Carcinoma, Lung, Non-Small-Cell 27602093 C34.90 D002289 HP:0030358 miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor. other hsa-mir-145 Carcinoma, Lung, Non-Small-Cell 28347234 C34.90 D002289 HP:0030358 Clinical value of miR-145-5p in NSCLC and potential molecular mechanism exploration: A retrospective study based on GEO, qRT-PCR, and TCGA data. other hsa-mir-145 Carcinoma, Lung, Non-Small-Cell 26780934 C34.90 D002289 HP:0030358 TP53 knockdown reduced the miRNA hsa-miR-145 other hsa-mir-145 Carcinoma, Lung, Non-Small-Cell 29266356 C34.90 D002289 HP:0030358 Effect of microRNA-145 on proliferation and apoptosis of human non-small cell lung cancer A549 cells by regulating mTOR signaling pathway other hsa-mir-150 Carcinoma, Lung, Non-Small-Cell 23670238 C34.90 D002289 HP:0030358 These findings suggest that miR-150, p53 protein and relevant miRNAs are members of a regulatory network in NSCLC tumorigenesis. other hsa-mir-155 Carcinoma, Lung, Non-Small-Cell 21350005 C34.90 D002289 HP:0030358 Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort. other hsa-mir-15a Carcinoma, Lung, Non-Small-Cell 19549910 C34.90 D002289 HP:0030358 miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. other hsa-mir-15a Carcinoma, Lung, Non-Small-Cell 26314859 C34.90 D002289 HP:0030358 We found that induced expression of hsa-miR-15a-3p via mimic transfection sensitised cisplatin-resistant cells to apoptosis and autophagy. other hsa-mir-16 Carcinoma, Lung, Non-Small-Cell 19549910 C34.90 D002289 HP:0030358 miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. other hsa-mir-16 Carcinoma, Lung, Non-Small-Cell 23349018 C34.90 D002289 HP:0030358 Expression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples. other hsa-mir-17 Carcinoma, Lung, Non-Small-Cell 21350005 C34.90 D002289 HP:0030358 Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort. other hsa-mir-182 Carcinoma, Lung, Non-Small-Cell 27073334 C34.90 D002289 HP:0030358 MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin other hsa-mir-195 Carcinoma, Lung, Non-Small-Cell 28848163 C34.90 D002289 HP:0030358 Knockdown of Lncrna PVT1 Enhances Radiosensitivity in Non-Small Cell Lung Cancer by Sponging Mir-195. other hsa-mir-200a Carcinoma, Lung, Non-Small-Cell 23708087 C34.90 D002289 HP:0030358 The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. other hsa-mir-200a Carcinoma, Lung, Non-Small-Cell 27396618 C34.90 D002289 HP:0030358 we show that down-regulating Zeb-1 by inducing miR-200a or 尾-Catenin siRNA can increase drug sensitivity of TKI-resistant cells. other hsa-mir-200b Carcinoma, Lung, Non-Small-Cell 23708087 C34.90 D002289 HP:0030358 The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. other hsa-mir-205 Carcinoma, Lung, Non-Small-Cell 21263248 C34.90 D002289 HP:0030358 In conclusion, the relative quantification of miR-205 and miR-21 seems to be a promising diagnostic tool other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 21263248 C34.90 D002289 HP:0030358 In conclusion, the relative quantification of miR-205 and miR-21 seems to be a promising diagnostic tool other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 21350005 C34.90 D002289 HP:0030358 Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 28096685 C34.90 D002289 HP:0030358 The role of microRNA-21 in predicting brain metastases from non-small cell lung cancer. other hsa-mir-216b Carcinoma, Lung, Non-Small-Cell 26852748 C34.90 D002289 HP:0030358 microRNA (miR)-216b levels were significantly downregulated in paclitaxel-treated NSCLC cells. other hsa-mir-224 Carcinoma, Lung, Non-Small-Cell 29387235 C34.90 D002289 HP:0030358 Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy other hsa-mir-29b Carcinoma, Lung, Non-Small-Cell 27199349 C34.90 D002289 HP:0030358 Overall, our results reveal a complexity in cancer for miR-29b, which can act as either an oncogene or tumor suppressor gene depending on signaling context. other hsa-mir-29b Carcinoma, Lung, Non-Small-Cell 26776158 C34.90 D002289 HP:0030358 knockdown of ETS1 led to upregulation of eight microRNAs and downregulation of miR-29b in the immune-evasion subtype. other hsa-mir-29b Carcinoma, Lung, Non-Small-Cell 27555773 C34.90 D002289 HP:0030358 Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. other hsa-mir-30a Carcinoma, Lung, Non-Small-Cell 28158983 C34.90 D002289 HP:0030358 CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer. other hsa-mir-342 Carcinoma, Lung, Non-Small-Cell 29387235 C34.90 D002289 HP:0030358 Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy other hsa-mir-34a Carcinoma, Lung, Non-Small-Cell 29387235 C34.90 D002289 HP:0030358 Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy other hsa-mir-361 Carcinoma, Lung, Non-Small-Cell 27779659 C34.90 D002289 HP:0030358 microRNA-361 targets Wilms' tumor 1 to inhibit the growth, migration and invasion of non-small-cell lung cancer cells. other hsa-mir-361 Carcinoma, Lung, Non-Small-Cell 28051257 C34.90 D002289 HP:0030358 Downregulation of miR-361-5p associates with aggressive clinicopathological features and unfavorable prognosis in non-small cell lung cancer. other hsa-mir-378 Carcinoma, Lung, Non-Small-Cell 23617628 C34.90 D002289 HP:0030358 Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis. other hsa-mir-381 Carcinoma, Lung, Non-Small-Cell 26640150 C34.90 D002289 HP:0030358 ADAR1 overexpression enhances the editing frequencies of target transcripts such as NEIL1 and miR-381. other hsa-mir-383 Carcinoma, Lung, Non-Small-Cell 27551765 C34.90 D002289 HP:0030358 MicroRNA-383 is a tumor suppressor and potential prognostic biomarker in human non-small cell lung caner. other hsa-mir-424 Carcinoma, Lung, Non-Small-Cell 27666545 C34.90 D002289 HP:0030358 Effects of miR-424 on Proliferation and Migration Abilities in Non-small Cell Lung Cancer A549 Cells and Its Molecular Mechanism. other hsa-mir-519d Carcinoma, Lung, Non-Small-Cell 27447710 C34.90 D002289 HP:0030358 The aim of the study was to evaluate the expression levels of selected miRNAs: miR-26a, miR-29b and miR-519d, and their target gene, matrix metalloproteinase-2 (MMP-2) in patients with non-small cell lung cancer (NSCLC). other hsa-mir-635 Carcinoma, Lung, Non-Small-Cell 27810784 C34.90 D002289 HP:0030358 The microRNA-635 suppresses tumorigenesis in non-small cell lung cancer. other hsa-mir-661 Carcinoma, Lung, Non-Small-Cell 28716024 C34.90 D002289 HP:0030358 MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer other hsa-mir-7 Carcinoma, Lung, Non-Small-Cell 28229971 C34.90 D002289 HP:0030358 Breviscapine suppresses the growth of non-small cell lung cancer by enhancing microRNA-7 expression. other hsa-mir-7 Carcinoma, Lung, Non-Small-Cell 25289099 C34.90 D002289 HP:0030358 Upregulation of miR-7 enhanced the PTX-sensitivity of NSCLC cells by suppressing cell proliferation and promoting cell apoptosis other hsa-mir-7 Carcinoma, Lung, Non-Small-Cell 26557760 C34.90 D002289 HP:0030358 We found that miR-7 significantly decreased the IC50 of gefitinib and inhibited cell growth other hsa-mir-92a Carcinoma, Lung, Non-Small-Cell 28534966 C34.90 D002289 HP:0030358 MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis. other hsa-mir-92b Carcinoma, Lung, Non-Small-Cell 27775799 C34.90 D002289 HP:0030358 Regulation of Twist in the metastasis of non-small cell lung cancer by miR-92b. other hsa-mir-9501 Carcinoma, Lung, Non-Small-Cell 27734264 C34.90 D002289 HP:0030358 The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer. other hsa-mir-96 Carcinoma, Lung, Non-Small-Cell 28656287 C34.90 D002289 HP:0030358 Identification and characterization of miR-96, a potential biomarker of NSCLC, through bioinformatic analysis. other hsa-let-7 Carcinoma, Lung, Non-Small-Cell 25714397 C34.90 D002289 HP:0030358 Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. other hsa-let-7g Carcinoma, Lung, Non-Small-Cell 23820752 C34.90 D002289 HP:0030358 Let-7g and miR-21 expression in non-small cell lung cancer: correlation with clinicopathological and molecular features other hsa-mir-101-1 Carcinoma, Lung, Non-Small-Cell 22014955 C34.90 D002289 HP:0030358 The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. other hsa-mir-101-2 Carcinoma, Lung, Non-Small-Cell 22014955 C34.90 D002289 HP:0030358 The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. other hsa-mir-106a Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-10b Carcinoma, Lung, Non-Small-Cell 25988292 C34.90 D002289 HP:0030358 microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells. other hsa-mir-10b Carcinoma, Lung, Non-Small-Cell 24198203 C34.90 D002289 HP:0030358 microRNA expression profiles associated with survival, disease progression, and response to gefitinib in completely resected non-small-cell lung cancer with EGFR mutation. other hsa-mir-1-1 Carcinoma, Lung, Non-Small-Cell 20194856 C34.90 D002289 HP:0030358 significantly associated with overal survival other hsa-mir-1-2 Carcinoma, Lung, Non-Small-Cell 20194856 C34.90 D002289 HP:0030358 significantly associated with overal survival other hsa-mir-221 Carcinoma, Lung, Non-Small-Cell 25641933 C34.90 D002289 HP:0030358 Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. other hsa-mir-222 Carcinoma, Lung, Non-Small-Cell 25641933 C34.90 D002289 HP:0030358 Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. other hsa-mir-122 Carcinoma, Lung, Non-Small-Cell 26389880 C34.90 D002289 HP:0030358 These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy. other hsa-mir-124-1 Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-1246 Carcinoma, Lung, Non-Small-Cell 26711929 C34.90 D002289 HP:0030358 Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC.CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC. other hsa-mir-125b Carcinoma, Lung, Non-Small-Cell 25772251 C34.90 D002289 HP:0030358 Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer. other hsa-mir-125b-1 Carcinoma, Lung, Non-Small-Cell 23718732 C34.90 D002289 HP:0030358 MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. other hsa-mir-125b-2 Carcinoma, Lung, Non-Small-Cell 23718732 C34.90 D002289 HP:0030358 MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. other hsa-mir-126 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-126 Carcinoma, Lung, Non-Small-Cell 22900072 C34.90 D002289 HP:0030358 MicroRNA-126 Inhibits Tumor Cell Growth and Its Expression Level Correlates with Poor Survival in Non-Small Cell Lung Cancer Patients. other hsa-mir-1290 Carcinoma, Lung, Non-Small-Cell 26711929 C34.90 D002289 HP:0030358 Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC.CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC. other hsa-mir-1290 Carcinoma, Lung, Non-Small-Cell 25016979 C34.90 D002289 HP:0030358 miR-1290 suppresses cell viability and cell cycle progression. These data provide insight into miR-1290-mediated cellular mechanisms in asiatic acid-treated A549 non-small cell lung carcinoma cells. other hsa-mir-133a Carcinoma, Lung, Non-Small-Cell 24816813 C34.90 D002289 HP:0030358 MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. other hsa-mir-135a-1 Carcinoma, Lung, Non-Small-Cell 21552288 C34.90 D002289 HP:0030358 miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. other hsa-mir-135a-1 Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-135a-2 Carcinoma, Lung, Non-Small-Cell 21552288 C34.90 D002289 HP:0030358 miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. other hsa-mir-135a-2 Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-135b Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-136 Carcinoma, Lung, Non-Small-Cell 23959478 C34.90 D002289 HP:0030358 miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells. other hsa-mir-138-1 Carcinoma, Lung, Non-Small-Cell 21787234 C34.90 D002289 HP:0030358 miR-138 could play an important role in the development of cisplatin resistance in non-small cell lung cancer (NSCLC) other hsa-mir-138-2 Carcinoma, Lung, Non-Small-Cell 21787234 C34.90 D002289 HP:0030358 miR-138 could play an important role in the development of cisplatin resistance in non-small cell lung cancer (NSCLC) other hsa-mir-144 Carcinoma, Lung, Non-Small-Cell 24066116 C34.90 D002289 HP:0030358 Our results for the first time showed mir-144-ZFX pathway is involved in the development of NSCLC, which sheds a light for further investigations on underlying mechanisms toward better understanding and management of NSCLC. other hsa-mir-145 Carcinoma, Lung, Non-Small-Cell 22331473 C34.90 D002289 HP:0030358 miR-145* inhibits cell invasion and metastasis, and is associated with brain metastasis. other hsa-mir-145 Carcinoma, Lung, Non-Small-Cell 25661374 C34.90 D002289 HP:0030358 Low miR-145 expression level is associated with poor pathological differentiation and poor prognosis in non-small cell lung cancer. other hsa-mir-148a Carcinoma, Lung, Non-Small-Cell 23843100 C34.90 D002289 HP:0030358 Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer. other hsa-mir-148b Carcinoma, Lung, Non-Small-Cell 26377406 C34.90 D002289 HP:0030358 Our findings demonstrated that miR-148b may play a role as independent prognostic factor for patients with NSCLC. other hsa-mir-149 Carcinoma, Lung, Non-Small-Cell 24007627 C34.90 D002289 HP:0030358 A two miRNA signature (miR-149 and miR-375) was found predictive for response and was also associated to progression-free survival (p = 0.05). other hsa-mir-152 Carcinoma, Lung, Non-Small-Cell 25190353 C34.90 D002289 HP:0030358 MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2. other hsa-mir-155 Carcinoma, Lung, Non-Small-Cell 21219656 C34.90 D002289 HP:0030358 The prognostic impact of miR-155 depends on histological subtype and nodal status in NSCLC. other hsa-mir-155 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-155 Carcinoma, Lung, Non-Small-Cell 26322518 C34.90 D002289 HP:0030358 These results suggest that miR-155 expression is not significantly related to non-small cell lung cancer patients except in patients from Asian and America. other hsa-mir-155 Carcinoma, Lung, Non-Small-Cell 23817461 C34.90 D002289 HP:0030358 This meta-analysis provides evidence that miR-21 and miR-155 are predicting factors for non-small-cell lung cancer prognosis and lymphoid infiltration. other hsa-mir-15a Carcinoma, Lung, Non-Small-Cell 21575235 C34.90 D002289 HP:0030358 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. other hsa-mir-16-1 Carcinoma, Lung, Non-Small-Cell 21575235 C34.90 D002289 HP:0030358 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. other hsa-mir-16-2 Carcinoma, Lung, Non-Small-Cell 21575235 C34.90 D002289 HP:0030358 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. other hsa-mir-17 Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-17 Carcinoma, Lung, Non-Small-Cell 24200043 C34.90 D002289 HP:0030358 This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies. other hsa-mir-17 Carcinoma, Lung, Non-Small-Cell 26482648 C34.90 D002289 HP:0030358 Our study indicates that miR-17 and miR-92 families play important roles in cisplatin resistance and can be used as potential biomarkers for better predicting the clinical response to platinum-based chemotherapy in NSCLC. other hsa-mir-182 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-186 Carcinoma, Lung, Non-Small-Cell 23671127 C34.90 D002289 HP:0030358 PTTG1 promotes migration and invasion of human non-small cell lung cancer cells and is modulated by miR-186. other hsa-mir-18a Carcinoma, Lung, Non-Small-Cell 25755757 C34.90 D002289 HP:0030358 Effect of miR-18a overexpression on the radiosensitivity of non-small cell lung cancer. other hsa-mir-193b Carcinoma, Lung, Non-Small-Cell 22491710 C34.90 D002289 HP:0030358 MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells. other hsa-mir-200c Carcinoma, Lung, Non-Small-Cell 22045191 C34.90 D002289 HP:0030358 Ectopic expression of mir-200c alters expression of EMT proteins, sensitivity to erlotinib, and migration in lung cells. other hsa-mir-203 Carcinoma, Lung, Non-Small-Cell 26683818 C34.90 D002289 HP:0030358 Our results suggest that LASP-1, mediated by miR-203,has crucial functions in the proliferation, migration and invasion of NSCLC. other hsa-mir-205 Carcinoma, Lung, Non-Small-Cell 26311306 C34.90 D002289 HP:0030358 Validation for histology-driven diagnosis in non-small cell lung cancer using hsa-miR-205 and hsa-miR-21 expression by two different normalization strategies. other hsa-mir-205 Carcinoma, Lung, Non-Small-Cell 26001154 C34.90 D002289 HP:0030358 the MiR-205 can also increase in the case with severe inflammation and benign tumor.3 The possibility of false-positive because of noncancerous lesion has to be further studied. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 20832755 C34.90 D002289 HP:0030358 miR-21:Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 22237007 C34.90 D002289 HP:0030358 Increased miR-21 expression significantly increased the resistance of A549 cell to platinum, whereas reduced miR-21 decreased the resistance of A549/CDDP cell. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 23820752 C34.90 D002289 HP:0030358 Let-7g and miR-21 expression in non-small cell lung cancer: correlation with clinicopathological and molecular features other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 24452750 C34.90 D002289 HP:0030358 Expression of microRNA-21 in non-small cell lung cancer tissue increases with disease progression and is likely caused by growth conditional changes during malignant transformation. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 26311306 C34.90 D002289 HP:0030358 Validation for histology-driven diagnosis in non-small cell lung cancer using hsa-miR-205 and hsa-miR-21 expression by two different normalization strategies. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 26453197 C34.90 D002289 HP:0030358 Up-Regulation of miR-21 Expression Predicate Advanced Clinicopathological Features and Poor Prognosis in Patients with Non-Small Cell Lung Cancer. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 23817461 C34.90 D002289 HP:0030358 This meta-analysis provides evidence that miR-21 and miR-155 are predicting factors for non-small-cell lung cancer prognosis and lymphoid infiltration. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 24198203 C34.90 D002289 HP:0030358 microRNA expression profiles associated with survival, disease progression, and response to gefitinib in completely resected non-small-cell lung cancer with EGFR mutation. other hsa-mir-21 Carcinoma, Lung, Non-Small-Cell 24906642 C34.90 D002289 HP:0030358 Downregulation of miR-21 increases cisplatin sensitivity of non-small-cell lung cancer. other hsa-mir-210 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-210 Carcinoma, Lung, Non-Small-Cell 24305009 C34.90 D002289 HP:0030358 We show that miR-210 in stromal cells, and co-expressed in cancer cells and stromal cells mediates an independent prognostic impact. It is a candidate marker for prognostic stratification in NSCLC. other hsa-mir-214 Carcinoma, Lung, Non-Small-Cell 22502680 C34.90 D002289 HP:0030358 MicroRNA-214 Regulates the Acquired Resistance to Gefitinib via the PTEN/AKT Pathway in EGFR-mutant Cell Lines. other hsa-mir-222 Carcinoma, Lung, Non-Small-Cell 24955421 C34.90 D002289 HP:0030358 MicroRNA-222 expression and its prognostic potential in non-small cell lung cancer. other hsa-mir-23a Carcinoma, Lung, Non-Small-Cell 24898878 C34.90 D002289 HP:0030358 There is an interaction between miR-23a and IRS-1 in the modulation of the migration and invasion of NSCLC cells. IRS-1 is variably expressed in NSCLC patients and correlates with NSCLC patient survival. other hsa-mir-27a Carcinoma, Lung, Non-Small-Cell 25773791 C34.90 D002289 HP:0030358 Rs895819 within miR-27a might be involved in development of non small cell lung cancer in the Chinese Han population. other hsa-mir-29b-1 Carcinoma, Lung, Non-Small-Cell 22399498 C34.90 D002289 HP:0030358 increased after necitumumab in combination with cisplatin/gemcitabine other hsa-mir-29b-2 Carcinoma, Lung, Non-Small-Cell 22399498 C34.90 D002289 HP:0030358 increased after necitumumab in combination with cisplatin/gemcitabine other hsa-mir-30b Carcinoma, Lung, Non-Small-Cell 24286402 C34.90 D002289 HP:0030358 Our study identified miR-30b and miR-30c as useful prognostic predictors in NSCLC patients who underwent first line treatment with TKIs. other hsa-mir-30c Carcinoma, Lung, Non-Small-Cell 24286402 C34.90 D002289 HP:0030358 Our study identified miR-30b and miR-30c as useful prognostic predictors in NSCLC patients who underwent first line treatment with TKIs. other hsa-mir-30d Carcinoma, Lung, Non-Small-Cell 20194856 C34.90 D002289 HP:0030358 significantly associated with overal survival other hsa-mir-3127 Carcinoma, Lung, Non-Small-Cell 25284075 C34.90 D002289 HP:0030358 Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. other hsa-mir-328 Carcinoma, Lung, Non-Small-Cell 21448905 C34.90 D002289 HP:0030358 MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. other hsa-mir-34 Carcinoma, Lung, Non-Small-Cell 25714397 C34.90 D002289 HP:0030358 Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. other hsa-mir-34a Carcinoma, Lung, Non-Small-Cell 21575235 C34.90 D002289 HP:0030358 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. other hsa-mir-34a Carcinoma, Lung, Non-Small-Cell 24595209 C34.90 D002289 HP:0030358 The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells. other hsa-mir-34a Carcinoma, Lung, Non-Small-Cell 26406332 C34.90 D002289 HP:0030358 Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells. other hsa-mir-34a Carcinoma, Lung, Non-Small-Cell 24444609 C34.90 D002289 HP:0030358 Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. other hsa-mir-3619 Carcinoma, Lung, Non-Small-Cell 26512718 C34.90 D002289 HP:0030358 Our data demonstrate a previously unappreciated role for miR-3619-5p,in suppression of β-catenin-mediated cancer growth and invasion in NSCLC cells,and highlight miR-3619-5p as a novel cancer suppressor in NSCLC. other hsa-mir-375 Carcinoma, Lung, Non-Small-Cell 24404590 C34.90 D002289 HP:0030358 Decreased circulating miR-375: a potential biomarker for patients with non-small-cell lung cancer. other hsa-mir-378a Carcinoma, Lung, Non-Small-Cell 22052152 C34.90 D002289 HP:0030358 MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. other hsa-mir-424 Carcinoma, Lung, Non-Small-Cell 22295063 C34.90 D002289 HP:0030358 The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001). other hsa-mir-449a Carcinoma, Lung, Non-Small-Cell 25424357 C34.90 D002289 HP:0030358 The tumor suppression role of microRNA-449a could be due to its promotion of tumor cell proliferation and its inhibition of tumor cell apoptosis. other hsa-mir-451a Carcinoma, Lung, Non-Small-Cell 21329503 C34.90 D002289 HP:0030358 Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). other hsa-mir-485 Carcinoma, Lung, Non-Small-Cell 23734217 C34.90 D002289 HP:0030358 hsa-mir-485 Prostatic Neoplasms Prostatic Neoplasms Cytotoxic treatment of DU-145 cells enhanced the release of PCS-miRNAs with the exception of miR-485-3p which was retained by surviving cells. other hsa-mir-486 Carcinoma, Lung, Non-Small-Cell 20194856 C34.90 D002289 HP:0030358 significantly associated with overal survival other hsa-mir-494 Carcinoma, Lung, Non-Small-Cell 25861022 C34.90 D002289 HP:0030358 Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer. other hsa-mir-495 Carcinoma, Lung, Non-Small-Cell 24038379 C34.90 D002289 HP:0030358 miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A). other hsa-mir-497 Carcinoma, Lung, Non-Small-Cell 26485685 C34.90 D002289 HP:0030358 Together, our data demonstrate a previously unappreciated role for miR-497 in suppression of VEGF-A-mediated NSCLC cancer cell growth and invasion. other hsa-mir-499a Carcinoma, Lung, Non-Small-Cell 20194856 C34.90 D002289 HP:0030358 significantly associated with overal survival other hsa-mir-512 Carcinoma, Lung, Non-Small-Cell 25687035 C34.90 D002289 HP:0030358 Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. other hsa-mir-520a Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-520b Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-520c Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-520d Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-520e Carcinoma, Lung, Non-Small-Cell 22370637 C34.90 D002289 HP:0030358 The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. other hsa-mir-570 Carcinoma, Lung, Non-Small-Cell 24200043 C34.90 D002289 HP:0030358 This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies. other hsa-mir-590 Carcinoma, Lung, Non-Small-Cell 24200043 C34.90 D002289 HP:0030358 This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies. other hsa-mir-92a Carcinoma, Lung, Non-Small-Cell 26482648 C34.90 D002289 HP:0030358 Our study indicates that miR-17 and miR-92 families play important roles in cisplatin resistance and can be used as potential biomarkers for better predicting the clinical response to platinum-based chemotherapy in NSCLC. other hsa-mir-92b Carcinoma, Lung, Non-Small-Cell 24099768 C34.90 D002289 HP:0030358 The miR-92b play an oncogene roles by regulatescell growth, cisplatin chemosensitivity phenotype, and could serve as a novel potential maker for NSCLC therapy. other hsa-mir-99a Carcinoma, Lung, Non-Small-Cell 25046358 C34.90 D002289 HP:0030358 A novel small-molecule compound diaporine A inhibits non-small cell lung cancer growth by regulating miR-99a/mTOR signaling. other hsa-mir-26a Carcinoma, Lung, Small-Cell 27644194 C34.90 D055752 182280 HP:0030357 KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer. other hsa-mir-29a Carcinoma, Lung, Small-Cell 23043084 C34.90 D055752 182280 HP:0030357 Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens. other hsa-mir-375 Carcinoma, Lung, Small-Cell 23043084 C34.90 D055752 182280 HP:0030357 Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens. other hsa-mir-375 Carcinoma, Merkel Cell 26877261 disease of cellular proliferation DOID:3965 C4A.9 D015266 HP:0030447 Roles for miR-375 in Neuroendocrine Differentiation and Tumor Suppression via Notch Pathway Suppression in Merkel Cell Carcinoma. other hsa-mir-10b Carcinoma, Nasopharyngeal 24175854 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 miR-10b promotes migration and invasion in nasopharyngeal carcinoma cells. other hsa-mir-1204 Carcinoma, Nasopharyngeal 25756509 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo. other hsa-mir-125a Carcinoma, Nasopharyngeal 24896104 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p. other hsa-mir-141 Carcinoma, Nasopharyngeal 20053927 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 We propose that miR-141- and tumor-related genes c-MYC, SPLUNC1, BRD3, UBAP1 and PTEN may constitute a gene-miRNA network to contribute to NPC development. other hsa-mir-142 Carcinoma, Nasopharyngeal 26183850 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 MiR-142-3p Suppresses SOCS6 Expression and Promotes Cell Proliferation in Nasopharyngeal Carcinoma. other hsa-mir-143 Carcinoma, Nasopharyngeal 25701793 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Identification of miR-143 as a tumour suppressor in nasopharyngeal carcinoma based on microRNA expression profiling. other hsa-mir-146a Carcinoma, Nasopharyngeal 24430575 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population. other hsa-mir-152 Carcinoma, Nasopharyngeal 26135619 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Our findings provide new insights into the metastasis of NPC regulated by EBV and advocate for developing clinical intervention strategies against NPC. other hsa-mir-152 Carcinoma, Nasopharyngeal 27840403 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells. other hsa-mir-155 Carcinoma, Nasopharyngeal 24241359 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 MiR-155 up-regulation by LMP1 DNA contributes to increased nasopharyngeal carcinoma cell proliferation and migration. other hsa-mir-195 Carcinoma, Nasopharyngeal 26135619 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Our findings provide new insights into the metastasis of NPC regulated by EBV and advocate for developing clinical intervention strategies against NPC. other hsa-mir-200a Carcinoma, Nasopharyngeal 20826811 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Our findings reveal for the first time the function of miR-200a in shifting nasopharyngeal carcinoma cell states via a reversible process coined as epithelial-mesenchymal to stem-like transition through differential and specific mechanisms. other hsa-mir-203 Carcinoma, Nasopharyngeal 27589832 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma. other hsa-mir-204 Carcinoma, Nasopharyngeal 25752113 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Clinical significance of miRNA-204 in nasopharyngeal carcinoma. other hsa-mir-21 Carcinoma, Nasopharyngeal 26568302 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 LMP1 greatly increased expression of miR-21 and downregulated expression of the miR-21 target other hsa-mir-31 Carcinoma, Nasopharyngeal 28042945 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma. other hsa-mir-324 Carcinoma, Nasopharyngeal 25735100 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 The loss of miRNA-324-3p and ectopic WNT2B might co-induce the initiation and progression of NPC. other hsa-mir-34a Carcinoma, Nasopharyngeal 25231528 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Hypofractionated radiotherapy induces miR-34a expression and enhances apoptosis in human nasopharyngeal carcinoma cells. other hsa-mir-34c Carcinoma, Nasopharyngeal 26795575 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Our study presents the current knowledge of miRNA regulatory network in NPC with combination of bioinformatics analysis and literature research. The hypothesis of miR-34c regulatory pathway may be beneficial in guiding further studies on the molecular mechanism of NPC tumorigenesis. other hsa-mir-494 Carcinoma, Nasopharyngeal 25809707 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma. other hsa-mir-744 Carcinoma, Nasopharyngeal 25961434 disease of cellular proliferation DOID:9261 C11 C538339 607107 HP:0100630 MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. other hsa-mir-25 Carcinoma, Neuroendocrine 25512615 disease of cellular proliferation DOID:1800 C7A D018278 HP:0100634 The pathogenesis of prostatic SCNC involves a p53 and Aurora Kinase A signaling mechanism, both potentially targetable pathways. other hsa-mir-124 Carcinoma, Oral 28077301 gastrointestinal system disease DOID:0050610 MiR-124 down-regulation is critical for cancer associated fibroblasts-enhanced tumor growth of oral carcinoma. other hsa-mir-21 Carcinoma, Oral 22249446 gastrointestinal system disease DOID:0050610 miR-21 inhibitor sensitizes human OSCC(oral squamous cell carcinoma) cells to cisplatin. other hsa-mir-21 Carcinoma, Oral 22761427 gastrointestinal system disease DOID:0050610 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. other hsa-mir-27a Carcinoma, Oral 23472065 gastrointestinal system disease DOID:0050610 Primary Microcephaly Gene MCPH1 Shows Signatures of Tumor Suppressors and Is Regulated by miR-27a in Oral Squamous Cell Carcinoma other hsa-mir-7-1 Carcinoma, Oral 22761427 gastrointestinal system disease DOID:0050610 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. other hsa-mir-7-2 Carcinoma, Oral 22761427 gastrointestinal system disease DOID:0050610 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. other hsa-mir-7-3 Carcinoma, Oral 22761427 gastrointestinal system disease DOID:0050610 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. other hsa-let-7a Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-100 Carcinoma, Ovarian 27748936 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 miR-100 resensitizes resistant epithelial ovarian cancer to cisplatin. other hsa-mir-101 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-103a Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-122 Carcinoma, Ovarian 25195148 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 A polymorphism at miRNA-122-binding site in the IL-1α 3'UTR is associated with risk of epithelial ovarian cancer. other hsa-mir-1284 Carcinoma, Ovarian 28281963 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MicroRNA-1284 Inhibits Cell Viability and Induces Apoptosis of Ovarian Cancer Cell Line OVCAR3. other hsa-mir-130a Carcinoma, Ovarian 26043084 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. other hsa-mir-132 Carcinoma, Ovarian 27673409 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MicroRNA and long non-coding RNA have potential clinical utility in the diagnosis of ovarian cancer and predicting prognosis, metastasis, recurrence, and response to therapy other hsa-mir-137 Carcinoma, Ovarian 25955305 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo. other hsa-mir-145 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-16 Carcinoma, Ovarian 28067383 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The functional consequences and prognostic value of dosage sensitivity in ovarian cancer. other hsa-mir-16 Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-182 Carcinoma, Ovarian 27748882 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response. other hsa-mir-191 Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-196a Carcinoma, Ovarian 26097603 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 In conclusion, miR-196a may play an important role in the progression of ovarian carcinoma, and could be used as an independent prognostic biomarker for patients with ovarian carcinoma. other hsa-mir-199a Carcinoma, Ovarian 25839163 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma. other hsa-mir-200 Carcinoma, Ovarian 26213923 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer. other hsa-mir-200 Carcinoma, Ovarian 28245631 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer. other hsa-mir-200 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-203 Carcinoma, Ovarian 27655286 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. other hsa-mir-21 Carcinoma, Ovarian 27840916 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA‑21 and the suppression of the PI3K/Akt‑NF‑κB signaling pathway in an in vitro model of ovarian carcinoma. other hsa-mir-210 Carcinoma, Ovarian 24715221 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis. other hsa-mir-214 Carcinoma, Ovarian 28175963 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer. other hsa-mir-214 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-23b Carcinoma, Ovarian 28245631 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer. other hsa-mir-25 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-26a Carcinoma, Ovarian 27673409 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MicroRNA and long non-coding RNA have potential clinical utility in the diagnosis of ovarian cancer and predicting prognosis, metastasis, recurrence, and response to therapy other hsa-mir-29b Carcinoma, Ovarian 24767251 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Involvement of miR-29b signaling in the sensitivity to chemotherapy in patients with ovarian carcinoma. other hsa-mir-29b Carcinoma, Ovarian 27832631 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 A Double-Negative Feedback Interaction between MicroRNA-29b and DNMT3A/3B Contributes to Ovarian Cancer Progression. other hsa-mir-30a Carcinoma, Ovarian 28222434 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. other hsa-mir-30c Carcinoma, Ovarian 28222434 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. other hsa-mir-31 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-335 Carcinoma, Ovarian 24515774 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Our results indicate that miR-335 relates to the prognosis of patients with EOC and is a promising predictor of EOC recurrence. other hsa-mir-34b Carcinoma, Ovarian 17823410 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Importantly, miR-34b and miR-34c cooperate in suppressing proliferation and soft-agar colony formation of neoplastic epithelial ovarian cells, in agreement with the partially overlapping spectrum of their predicted targets. other hsa-mir-34c Carcinoma, Ovarian 17823410 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Importantly, miR-34b and miR-34c cooperate in suppressing proliferation and soft-agar colony formation of neoplastic epithelial ovarian cells, in agreement with the partially overlapping spectrum of their predicted targets. other hsa-mir-372 Carcinoma, Ovarian 28456593 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The role of miR-372 in ovarian carcinoma cell proliferation. other hsa-mir-374a Carcinoma, Ovarian 26043084 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. other hsa-mir-376a Carcinoma, Ovarian 27979415 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MiR-376a promotion of proliferation and metastases in ovarian cancer other hsa-mir-383 Carcinoma, Ovarian 27567588 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene. other hsa-mir-423 Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-483 Carcinoma, Ovarian 27554045 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells. other hsa-mir-491 Carcinoma, Ovarian 25299770 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. other hsa-mir-506 Carcinoma, Ovarian 28601063 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role other hsa-mir-519d Carcinoma, Ovarian 28146423 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C. other hsa-mir-551a Carcinoma, Ovarian 28345465 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Demethoxycurcumin inhibited human epithelia ovarian cancer cells' growth via up-regulating miR-551a. other hsa-mir-6126 Carcinoma, Ovarian 27742688 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells. other hsa-mir-7 Carcinoma, Ovarian 28216373 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA. other hsa-mir-9 Carcinoma, Ovarian 25846738 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 MicroRNA-9 promotes tumorigenesis and mediates sensitivity to cisplatin in primary epithelial ovarian cancer cells. other hsa-mir-92a Carcinoma, Ovarian 27419385 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. other hsa-mir-93 Carcinoma, Ovarian 26087719 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells. other hsa-mir-98 Carcinoma, Ovarian 28067383 endocrine system disease DOID:4001 C56.9 C538090 167000 HP:0025318 The functional consequences and prognostic value of dosage sensitivity in ovarian cancer. other hsa-mir-21 Carcinoma, Ovarian, Clear Cell 25366985 endocrine system disease DOID:0050934 MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma. other hsa-mir-182 Carcinoma, Ovarian, Serous 24077281 endocrine system disease DOID:0050933 We describe several mechanisms responsible for FOXO3a inactivity, including chromosomal deletion (chromosome 6q21), upregulation of miRNA-182 and destabilization by activated PI3K and MEK. other hsa-mir-30a Carcinoma, Ovarian, Serous 23787480 endocrine system disease DOID:0050933 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. other hsa-mir-30a Carcinoma, Ovarian, Serous 25962395 endocrine system disease DOID:0050933 Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma. other hsa-mir-30e Carcinoma, Ovarian, Serous 23787480 endocrine system disease DOID:0050933 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. other hsa-mir-505 Carcinoma, Ovarian, Serous 23787480 endocrine system disease DOID:0050933 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. other hsa-mir-101 Carcinoma, Pancreatic 27988337 C25.3 C562463 260350 HP:0002894 micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine. other hsa-mir-124 Carcinoma, Pancreatic 29255366 C25.3 C562463 260350 HP:0002894 circRNA_100782 regulates BxPC3 cell proliferation by acting as miR-124 sponge through the IL6-STAT3 pathway other hsa-mir-125a Carcinoma, Pancreatic 28498896 C25.3 C562463 260350 HP:0002894 targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis, via miRNA regulation and siRNA-based therapy targeting it shows promise as a treatment for patients with pancreatic cancer other hsa-mir-1291 Carcinoma, Pancreatic 25115443 C25.3 C562463 260350 HP:0002894 N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. other hsa-mir-15b Carcinoma, Pancreatic 24892299 C25.3 C562463 260350 HP:0002894 Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. other hsa-mir-17 Carcinoma, Pancreatic 28280038 C25.3 C562463 260350 HP:0002894 The NOP14/mutp53 axis suppressed p21 expression at both the transcriptional and posttranscriptional levels via induction of miR-17-5p in PDAC cells other hsa-mir-196a Carcinoma, Pancreatic 26683934 C25.3 C562463 260350 HP:0002894 MiRNA-196a level may be a promising prognostic marker of recurrence in resected PanNETs, although further experimental investigation would be required. other hsa-mir-215 Carcinoma, Pancreatic 26063036 C25.3 C562463 260350 HP:0002894 miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas. other hsa-mir-24 Carcinoma, Pancreatic 26517093 C25.3 C562463 260350 HP:0002894 The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma. other hsa-mir-29c Carcinoma, Pancreatic 28088520 C25.3 C562463 260350 HP:0002894 Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway. other hsa-mir-33a Carcinoma, Pancreatic 26113407 C25.3 C562463 260350 HP:0002894 miR-33a suppresses the nuclear translocation of β-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells. other hsa-mir-374 Carcinoma, Pancreatic 27665739 C25.3 C562463 260350 HP:0002894 MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy. other hsa-mir-4787 Carcinoma, Pancreatic 27624777 C25.3 C562463 260350 HP:0002894 Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGFβ1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p. other hsa-mir-489 Carcinoma, Pancreatic 27793842 C25.3 C562463 260350 HP:0002894 KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis. other hsa-mir-601 Carcinoma, Pancreatic 27993677 C25.3 C562463 260350 HP:0002894 Identification of miR-601 as a novel regulator in the development of pancreatic cancer. other hsa-mir-663a Carcinoma, Pancreatic 27624777 C25.3 C562463 260350 HP:0002894 Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGFβ1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p. other hsa-mir-7 Carcinoma, Pancreatic 28450156 C25.3 C562463 260350 HP:0002894 microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. other hsa-mir-148a Carcinoma, Pancreatic Ductal 29660218 disease of cellular proliferation DOID:3587 C25.3 D021441 Molecular pathogenesis of pancreatic ductal adenocarcinoma: Impact of passenger strand of pre-miR-148a on gene regulation. other hsa-mir-1 Carcinoma, Prostate 28317618 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MiR-1, a Potential Predictive Biomarker for Recurrence in Prostate Cancer After Radical Prostatectomy. other hsa-mir-1 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-101 Carcinoma, Prostate 28384067 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells. other hsa-mir-129 Carcinoma, Prostate 27779679 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miR-129 predicts prognosis and inhibits cell growth in human prostate carcinoma. other hsa-mir-135a Carcinoma, Prostate 27524492 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Our data support a model in which hsa-miR-135-1 acts as a potential tumor suppressor in metastatic prostate cancer. other hsa-mir-139 Carcinoma, Prostate 27562849 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer. other hsa-mir-141 Carcinoma, Prostate 25921227 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 The work demonstrated here thus offers new opportunities for the construction of functional DNA nanostructures and for the application of these DNA nanostructures as an effective signal amplification means in the sensitive detection of nucleic acid biomarkers. other hsa-mir-141 Carcinoma, Prostate 27589398 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Sensitive detection of microRNA in complex biological samples by using two stages DSN-assisted target recycling signal amplification method. other hsa-mir-145 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-146a Carcinoma, Prostate 28101571 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer. other hsa-mir-181a Carcinoma, Prostate 28485104 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA-181a promotes docetaxel resistance in prostate cancer cells. other hsa-mir-181b Carcinoma, Prostate 28184935 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis. other hsa-mir-205 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-21 Carcinoma, Prostate 27725205 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21. other hsa-mir-21 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-221 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-24 Carcinoma, Prostate 28157714 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 The role of miR-24 as a race related genetic factor in prostate cancer. other hsa-mir-25 Carcinoma, Prostate 25858144 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression. other hsa-mir-30d Carcinoma, Prostate 28241827 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer. other hsa-mir-371 Carcinoma, Prostate 28005952 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. other hsa-mir-372 Carcinoma, Prostate 27730751 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Repression of MicroRNA-372 by Arsenic Sulphide Inhibits Prostate Cancer Cell Proliferation and Migration through Regulation of large tumour suppressor kinase 2. other hsa-mir-375 Carcinoma, Prostate 28320379 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 miRNAs associated with prostate cancer risk and progression. other hsa-mir-502 Carcinoma, Prostate 28578017 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population. other hsa-mir-512 Carcinoma, Prostate 28005952 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. other hsa-mir-663 Carcinoma, Prostate 28005952 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. other hsa-mir-665 Carcinoma, Prostate 28005952 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. other hsa-mir-671 Carcinoma, Prostate 28005952 disease of cellular proliferation DOID:10286 D07.5 D011471 176807 HP:0012125 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. other hsa-mir-100 Carcinoma, Rectal 26255374 disease of cellular proliferation DOID:1993 C20 D012004 The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC. other hsa-mir-141 Carcinoma, Rectal 18483486 disease of cellular proliferation DOID:1993 C20 D012004 Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. other hsa-mir-183 Carcinoma, Rectal 19935649 disease of cellular proliferation DOID:1993 C20 D012004 Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1. other hsa-mir-196a Carcinoma, Rectal 19418581 disease of cellular proliferation DOID:1993 C20 D012004 miR-196a exerts a pro-oncogenic influence in colorectal cancer. other hsa-mir-200c Carcinoma, Rectal 18483486 disease of cellular proliferation DOID:1993 C20 D012004 Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. other hsa-mir-200c Carcinoma, Rectal 19935649 disease of cellular proliferation DOID:1993 C20 D012004 Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1. other hsa-mir-203 Carcinoma, Rectal 19935649 disease of cellular proliferation DOID:1993 C20 D012004 Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1. other hsa-mir-203 Carcinoma, Rectal 21063914 disease of cellular proliferation DOID:1993 C20 D012004 miR-203 may be related to the proliferation and invasion of gastric and colorectal cancers. other hsa-mir-34a Carcinoma, Rectal 20734047 disease of cellular proliferation DOID:1993 C20 D012004 Satraplatin treatment induces p53-related genes and its direct microRNA target of miR-34a independently. other hsa-mir-34a Carcinoma, Rectal 28435028 disease of cellular proliferation DOID:1993 C20 D012004 Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. other hsa-mir-630 Carcinoma, Rectal 26255374 disease of cellular proliferation DOID:1993 C20 D012004 The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC. other hsa-mir-99a Carcinoma, Rectal 26255374 disease of cellular proliferation DOID:1993 C20 D012004 The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC. other hsa-let-7f Carcinoma, Renal Cell 20180642 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Transfection of miR-224 into HEK-293 cells resulted in decreased KLK1 protein levels. A luciferase assay demonstrated that hsa-let-7f can target KLK10 in the RCC cell line ACHN. other hsa-let-7i Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-125b Carcinoma, Renal Cell 28599452 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-125b is associated with renal cell carcinoma cell migration, invasion and apoptosis. other hsa-mir-126 Carcinoma, Renal Cell 25279769 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava. other hsa-mir-127 Carcinoma, Renal Cell 22492545 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-127-3p, miR-145, and miR-126 are significantly correlated with relapse-free survival of nonmetastatic RCC patients. other hsa-mir-133b Carcinoma, Renal Cell 27710896 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. other hsa-mir-135a Carcinoma, Renal Cell 27710896 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. other hsa-mir-138-1 Carcinoma, Renal Cell 21875287 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiR-138 Suppresses Expression of Hypoxia-inducible factor 1a (HIF-1a) in Clear Cell Renal Cell Carcinoma 786-O Cells. other hsa-mir-138-2 Carcinoma, Renal Cell 21875287 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiR-138 Suppresses Expression of Hypoxia-inducible factor 1a (HIF-1a) in Clear Cell Renal Cell Carcinoma 786-O Cells. other hsa-mir-141 Carcinoma, Renal Cell 24647573 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-141 serves as a potential biomarker for discriminating ccRCC from normal tissues and a crucial suppressor of ccRCC cell proliferation and metastasis by modulating the EphA2/p-FAK/p-AKT/MMPs signaling cascade. other hsa-mir-141 Carcinoma, Renal Cell 24810210 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling. other hsa-mir-141 Carcinoma, Renal Cell 25974855 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC. other hsa-mir-146a Carcinoma, Renal Cell 21472233 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Carbamylated albumin stimulates microRNA-146, which is increased in human renal cell carcinoma. other hsa-mir-146b Carcinoma, Renal Cell 21472233 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Carbamylated albumin stimulates microRNA-146, which is increased in human renal cell carcinoma. other hsa-mir-155 Carcinoma, Renal Cell 23050614 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma other hsa-mir-155 Carcinoma, Renal Cell 26064968 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. other hsa-mir-155 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-155 Carcinoma, Renal Cell 29056573 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Noncoding RNA Expression and Targeted Next-Generation Sequencing Distinguish Tubulocystic Renal Cell Carcinoma (TC-RCC) from Other Renal Neoplasms. other hsa-mir-15a Carcinoma, Renal Cell 28098906 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR‑15a‑5p acts as an oncogene in renal cell carcinoma. other hsa-mir-16 Carcinoma, Renal Cell 25815587 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Upregulated microRNA-16 as an oncogene in renal cell carcinoma. other hsa-mir-17 Carcinoma, Renal Cell 25011053 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/tumor initiating cell properties. other hsa-mir-17 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-18 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-184 Carcinoma, Renal Cell 21253009 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development other hsa-mir-184 Carcinoma, Renal Cell 21844955 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-184 show abnormal expression in human renal carcinoma. other hsa-mir-193b Carcinoma, Renal Cell 27802451 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma. other hsa-mir-195 Carcinoma, Renal Cell 28260025 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Identification of miR‑195‑3p as an oncogene in RCC. other hsa-mir-19a Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-19b-1 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-200 Carcinoma, Renal Cell 27580029 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Loss of fumarate hydratase is associated with suppression of miR-200 and the EMT signature in renal cancer and is associated with poor clinical outcome other hsa-mir-200a Carcinoma, Renal Cell 22082152 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. other hsa-mir-200c Carcinoma, Renal Cell 23754305 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 microRNA-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. other hsa-mir-200c Carcinoma, Renal Cell 25974855 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC. other hsa-mir-205 Carcinoma, Renal Cell 21330408 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. other hsa-mir-205 Carcinoma, Renal Cell 25600645 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 how overexpression of MALAT1 confers an oncogenic function in RCC that may offer a novel theranostic marker in this disease. other hsa-mir-206 Carcinoma, Renal Cell 21253009 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development other hsa-mir-20a Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-20a Carcinoma, Renal Cell 20022054 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Transfection of miR-20a inhibitor significantly decreased cell proliferation in a dose dependent manner. other hsa-mir-21 Carcinoma, Renal Cell 25279769 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava. other hsa-mir-21 Carcinoma, Renal Cell 25974855 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC. other hsa-mir-21 Carcinoma, Renal Cell 28714373 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma. other hsa-mir-21 Carcinoma, Renal Cell 29070781 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase. other hsa-mir-210 Carcinoma, Renal Cell 21253009 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development other hsa-mir-210 Carcinoma, Renal Cell 25974855 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC. other hsa-mir-210 Carcinoma, Renal Cell 23902947 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 VHL, involved in tumorigenesis of PGLs and clear cell renal cell carcinomas, may be an important player in the pathogenesis of sporadic HNPGLs via activation of an HIF-1α/miR-210 pHx pathway. other hsa-mir-210 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-221 Carcinoma, Renal Cell 26201448 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Gain of function experiments showed that miR-221 and miR-222 decreased angiogenesis and cellular proliferation in human umbilical vein endothelial cells (HUVEC) while increasing cellular proliferation in ACHN cells. miRNAs represent potential predictive markers for sunitinib response. other hsa-mir-221 Carcinoma, Renal Cell 25279769 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava. other hsa-mir-222 Carcinoma, Renal Cell 26201448 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Gain of function experiments showed that miR-221 and miR-222 decreased angiogenesis and cellular proliferation in human umbilical vein endothelial cells (HUVEC) while increasing cellular proliferation in ACHN cells. miRNAs represent potential predictive markers for sunitinib response. other hsa-mir-224 Carcinoma, Renal Cell 20180642 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Transfection of miR-224 into HEK-293 cells resulted in decreased KLK1 protein levels. A luciferase assay demonstrated that hsa-let-7f can target KLK10 in the RCC cell line ACHN. other hsa-mir-27a Carcinoma, Renal Cell 25973137 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-27a promotes cell proliferation and metastasis in renal cell carcinoma. other hsa-mir-30a Carcinoma, Renal Cell 25712526 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib. other hsa-mir-30b Carcinoma, Renal Cell 28259953 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Identification of miR‑30b as an oncogene in renal cell carcinoma. other hsa-mir-34a Carcinoma, Renal Cell 28045889 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells. other hsa-mir-34a Carcinoma, Renal Cell 29104726 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma. other hsa-mir-429 Carcinoma, Renal Cell 25974855 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC. other hsa-mir-429 Carcinoma, Renal Cell 27619681 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiR-429 is linked to metastasis and poor prognosis in renal cell carcinoma by affecting epithelial-mesenchymal transition. other hsa-mir-484 Carcinoma, Renal Cell 26064968 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. other hsa-mir-7 Carcinoma, Renal Cell 23793934 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 Identification of miR-7 as an oncogene in renal cell carcinoma. other hsa-mir-708 Carcinoma, Renal Cell 21852381 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. other hsa-mir-9-1 Carcinoma, Renal Cell 22082152 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. other hsa-mir-9-2 Carcinoma, Renal Cell 22082152 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. other hsa-mir-92-1 Carcinoma, Renal Cell 20964835 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue. other hsa-mir-9-3 Carcinoma, Renal Cell 22082152 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. other hsa-mir-99a Carcinoma, Renal Cell 23173671 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma other hsa-mir-99b Carcinoma, Renal Cell 23173671 disease of cellular proliferation DOID:4450 D002292 144700 HP:0005584 MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma other hsa-mir-1 Carcinoma, Renal Cell, Clear-Cell 26036633 disease of cellular proliferation DOID:4467 HP:0006770 MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis. other hsa-mir-10b Carcinoma, Renal Cell, Clear-Cell 24793999 disease of cellular proliferation DOID:4467 HP:0006770 The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma. other hsa-mir-10b Carcinoma, Renal Cell, Clear-Cell 28360191 disease of cellular proliferation DOID:4467 HP:0006770 miR-10b is a prognostic marker in clear cell renal cell carcinoma. other hsa-mir-10b Carcinoma, Renal Cell, Clear-Cell 29672315 disease of cellular proliferation DOID:4467 HP:0006770 MicroRNA-10b Promotes Apoptosis via JNK Pathway in Clear Cell Renal Cell Carcinoma other hsa-mir-125b Carcinoma, Renal Cell, Clear-Cell 25155155 disease of cellular proliferation DOID:4467 HP:0006770 Tumor miR-125b predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. other hsa-mir-143 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-145 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-15a Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-16 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-182 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-183 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-185 Carcinoma, Renal Cell, Clear-Cell 25700976 disease of cellular proliferation DOID:4467 HP:0006770 Our results suggest that the miR-185, as a tumor suppressor, plays a pivotal role by inhibiting VEGFA in VHL-inactivated ccRCC. other hsa-mir-200c Carcinoma, Renal Cell, Clear-Cell 27123083 disease of cellular proliferation DOID:4467 HP:0006770 Aza-induced upregulation of miR-200c may inhibit migration, invasion and EMT in ccRCC cells. other hsa-mir-21 Carcinoma, Renal Cell, Clear-Cell 24793999 disease of cellular proliferation DOID:4467 HP:0006770 The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma. other hsa-mir-21 Carcinoma, Renal Cell, Clear-Cell 26572589 disease of cellular proliferation DOID:4467 HP:0006770 Thus, a single miRNA may have an impact on the formation of highly tumorigenic cancer spheres in kidney cancer. other hsa-mir-217 Carcinoma, Renal Cell, Clear-Cell 23790169 disease of cellular proliferation DOID:4467 HP:0006770 miR-217 plays a tumor suppressor role in ccRCC. other hsa-mir-27a Carcinoma, Renal Cell, Clear-Cell 26046464 disease of cellular proliferation DOID:4467 HP:0006770 Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma. other hsa-mir-30a Carcinoma, Renal Cell, Clear-Cell 24402943 disease of cellular proliferation DOID:4467 HP:0006770 miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2α regulation. other hsa-mir-30c-2 Carcinoma, Renal Cell, Clear-Cell 24402943 disease of cellular proliferation DOID:4467 HP:0006770 miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2α regulation. other hsa-mir-335 Carcinoma, Renal Cell, Clear-Cell 25846734 disease of cellular proliferation DOID:4467 HP:0006770 miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. other hsa-mir-429 Carcinoma, Renal Cell, Clear-Cell 27549611 disease of cellular proliferation DOID:4467 HP:0006770 Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. other hsa-mir-584 Carcinoma, Renal Cell, Clear-Cell 21119662 disease of cellular proliferation DOID:4467 HP:0006770 Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma. other hsa-mir-96 Carcinoma, Renal Cell, Clear-Cell 25776476 disease of cellular proliferation DOID:4467 HP:0006770 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. other hsa-mir-200 Carcinoma, Skin 26527515 disease of cellular proliferation DOID:3451 D04.9 D018280 HP:0008069 only a functionally coherent group consisting of the miR-200 family members and miR-205-5p displays a pattern of progressive co-downregulation from the early toward the most aggressive stages of carcinogenesis. other hsa-mir-34a Carcinoma, Skin 24726431 disease of cellular proliferation DOID:3451 D04.9 D018280 HP:0008069 Our results demonstrate that p53 mutations increase apoptotic resistance in keratinocytes by interfering with miR-34a-mediated regulation of SIRT1 expression. other hsa-mir-146a Carcinoma, Thyroid 28103112 disease of cellular proliferation DOID:3963 C73 D013964 188550 HP:0002890 Potassium Iodate Differently Regulates the Proliferation, Migration, and Invasion of Human Thyroid Cancer Cells via Modulating miR-146a. other hsa-mir-146b Carcinoma, Thyroid 24946010 disease of cellular proliferation DOID:3963 C73 D013964 188550 HP:0002890 The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. other hsa-mir-21 Carcinoma, Thyroid 25316501 disease of cellular proliferation DOID:3963 C73 D013964 188550 HP:0002890 The PDCD4/miR-21 pathway in medullary thyroid carcinoma. other hsa-mir-27a Carcinoma, Thyroid 28002594 disease of cellular proliferation DOID:3963 C73 D013964 188550 HP:0002890 Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis. other hsa-mir-449b Carcinoma, Thyroid 26044563 disease of cellular proliferation DOID:3963 C73 D013964 188550 HP:0002890 Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b. other hsa-mir-144 Carcinoma, Thyroid, Anaplastic 29504819 C73 D065646 188550 HP:0011779 Effects of miR-144 on the sensitivity of human anaplastic thyroid carcinoma cells to cisplatin by autophagy regulation. other hsa-mir-146b Carcinoma, Thyroid, Anaplastic 27602131 C73 D065646 188550 HP:0011779 p21 participates in the regulation of anaplastic thyroid cancer cell proliferation by miR-146b. other hsa-mir-17 Carcinoma, Thyroid, Follicular 25748447 disease of cellular proliferation DOID:3962 C73 C572845 188470 HP:0006731 Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway. other hsa-mir-10a Carcinoma, Thyroid, Medullary 23685355 disease of cellular proliferation DOID:3973 C73 C536914 155240 HP:0002865 Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma. other hsa-mir-375 Carcinoma, Thyroid, Medullary 23685355 disease of cellular proliferation DOID:3973 C73 C536914 155240 HP:0002865 Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma. other hsa-let-7 Carcinoma, Thyroid, Papillary 27314338 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. other hsa-let-7e Carcinoma, Thyroid, Papillary 26414548 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. other hsa-mir-146 Carcinoma, Thyroid, Papillary 27011326 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 Family of microRNA-146 Regulates RARβ in Papillary Thyroid Carcinoma. other hsa-mir-155 Carcinoma, Thyroid, Papillary 27777199 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance. other hsa-mir-16 Carcinoma, Thyroid, Papillary 28085013 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC. other hsa-mir-181a Carcinoma, Thyroid, Papillary 27164936 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 MiRNA-21 and MiRNA-181a-5p were found to be expressed reciprocally in the exosomes of patients with papillary and follicular TC other hsa-mir-199a Carcinoma, Thyroid, Papillary 24810336 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. other hsa-mir-21 Carcinoma, Thyroid, Papillary 26007293 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. other hsa-mir-21 Carcinoma, Thyroid, Papillary 27164936 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 MiRNA-21 and MiRNA-181a-5p were found to be expressed reciprocally in the exosomes of patients with papillary and follicular TC other hsa-mir-221 Carcinoma, Thyroid, Papillary 28297755 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 Expression of microRNA-221 and IL-17 in papillary thyroid carcinoma and correlation with clinicopathologic features. other hsa-mir-9 Carcinoma, Thyroid, Papillary 26007293 disease of cellular proliferation DOID:3969 C73 C536915 188550 HP:0002895 MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. other hsa-mir-140 Carcinoma, Tounge 24530397 Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells. other hsa-mir-628 Cardiac Allograft Vasculopathy 27653298 T86.290 D014652 MicroRNA 628-5p as a Novel Biomarker for Cardiac Allograft Vasculopathy. other hsa-mir-21 Cardiac Fibrosis 22580345 we identify the protective transcriptome signature of enhanced PI3Kα signaling in the context of pathological hypertrophy, and demonstrate the regulation of TGF-β/miR-21 by which enhanced PI3Kα signaling protects against cardiac fibrosis. other hsa-mir-199a Cardiac Myocyte Injury 28077443 Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction. other hsa-mir-133a Cardiomegaly 25313674 I51.7 D006332 HP:0001640 Our observations supplied the possibility that circulating miR-133a could be a surrogate biomarker of cardiac hypertrophy in MHD patients. other hsa-mir-133a-1 Cardiomegaly 19096030 I51.7 D006332 HP:0001640 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-133a-2 Cardiomegaly 19096030 I51.7 D006332 HP:0001640 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-133b Cardiomegaly 19096030 I51.7 D006332 HP:0001640 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-15 Cardiomegaly 25103110 I51.7 D006332 HP:0001640 We identified the miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGFβ-pathway. other hsa-mir-21 Cardiomegaly 25644540 I51.7 D006332 HP:0001640 miR-21: a star player in cardiac hypertrophy. other hsa-mir-29a Cardiomegaly 25145535 I51.7 D006332 HP:0001640 MicroRNA-29a is a friend or foe for cardiac hypertrophy other hsa-mir-30a Cardiomegaly 19096030 I51.7 D006332 HP:0001640 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-30b Cardiomegaly 19096030 I51.7 D006332 HP:0001640 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-1 Cardiomegaly 19933931 I51.7 D006332 HP:0001640 Our results reveal a critical role of miR-1 in mediating the effects of the IGF-1 pathway and demonstrate a feedback loop between miR-1 expression and the IGF-1 signal transduction cascade. other hsa-mir-1 Cardiomegaly 28985746 I51.7 D006332 HP:0001640 Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension. other hsa-mir-126 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-133a Cardiomegaly 26845040 I51.7 D006332 HP:0001640 APN reversed miR-133a levels through AMPK activation other hsa-mir-155 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-17 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-199a-1 Cardiomegaly 20458739 I51.7 D006332 HP:0001640 miR-199a:miR-199a is essential for the maintenance of cell size in cardiomyocytes other hsa-mir-199a-2 Cardiomegaly 20458739 I51.7 D006332 HP:0001640 miR-199a:miR-199a is essential for the maintenance of cell size in cardiomyocytes other hsa-mir-208a Cardiomegaly 23623871 I51.7 D006332 HP:0001640 MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy - role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/α-MHC modulation. other hsa-mir-208b Cardiomegaly 23623871 I51.7 D006332 HP:0001640 MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy - role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/α-MHC modulation. other hsa-mir-21 Cardiomegaly 24743143 I51.7 D006332 HP:0001640 In particular, a passenger strand miR, miR-21*, was identified as a potent paracrine factor that induces cardiomyocyte hypertrophy when shuttled through exosomes. other hsa-mir-221 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-222 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-29a Cardiomegaly 28985746 I51.7 D006332 HP:0001640 Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension. other hsa-mir-31 Cardiomegaly 21946298 I51.7 D006332 HP:0001640 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-34a Cardiomegaly 26508703 I51.7 D006332 HP:0001640 Neonatal HHR had higher cardiac telomerase activity and expression of Tert and miR-34a. other hsa-mir-378 Cardiomegaly 23625957 I51.7 D006332 HP:0001640 MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. other hsa-mir-146 Cardiometabolic Disorders 26165231 Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs:Implications for Cardiometabolic Disorders. other hsa-mir-29 Cardiometabolic Disorders 26165231 Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs:Implications for Cardiometabolic Disorders. other hsa-let-7a Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-1295a Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-16-1 Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-19b-1 Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-21 Cardiomyopathy 19043405 cardiovascular system disease DOID:0050700 I42 D009202 miR-21: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts other hsa-mir-34b Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-371a Cardiomyopathy 26512958 cardiovascular system disease DOID:0050700 I42 D009202 In conclusion, the presence of a g2252c polymorphism in the BAG3 3'-UTR determines loss of miR-371a-5p binding and results in an altered response to epi, potentially representing a new molecular mechanism that contributes to TTC pathogenesis. other hsa-mir-99b Cardiomyopathy 27475403 cardiovascular system disease DOID:0050700 I42 D009202 Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p other hsa-mir-1 Cardiomyopathy, Hypertrophic 21464712 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy. other hsa-mir-125b-1 Cardiomyopathy, Hypertrophic 20470752 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-125b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth other hsa-mir-125b-2 Cardiomyopathy, Hypertrophic 20470752 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-125b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth other hsa-mir-133 Cardiomyopathy, Hypertrophic 21464712 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy. other hsa-mir-133 Cardiomyopathy, Hypertrophic 28322824 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications. other hsa-mir-133a Cardiomyopathy, Hypertrophic 21586423 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 Logistic regression analysis identified microRNA-133a as a significant positive predictor of LVM normalisation, whereas β-myosin heavy chain and BMI constituted negative predictors. other hsa-mir-133a Cardiomyopathy, Hypertrophic 23070543 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 Consistent with these structural changes, the expression of molecular markers of cardiac hypertrophy were also increased [Nppb(BNP), Myh7-Myh6(βMHC-αMHC) (both P < 0.05) and mir-133a (P < 0.01)]. other hsa-mir-133a Cardiomyopathy, Hypertrophic 28382463 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. other hsa-mir-133a-1 Cardiomyopathy, Hypertrophic 17786230 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-goбзCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells. other hsa-mir-133a-1 Cardiomyopathy, Hypertrophic 20013939 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR133a regulates cardiomyocyte hypertrophy in diabetes other hsa-mir-133a-2 Cardiomyopathy, Hypertrophic 17786230 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-goбзCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells. other hsa-mir-133a-2 Cardiomyopathy, Hypertrophic 20013939 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR133a regulates cardiomyocyte hypertrophy in diabetes other hsa-mir-16 Cardiomyopathy, Hypertrophic 25583328 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy. other hsa-mir-195 Cardiomyopathy, Hypertrophic 20470752 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-195:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth other hsa-mir-199b Cardiomyopathy, Hypertrophic 21464712 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy. other hsa-mir-208 Cardiomyopathy, Hypertrophic 21464712 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy. other hsa-mir-208a Cardiomyopathy, Hypertrophic 17965831 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-208 was recently shown to enhance stress-related cardiac muscle growth by up-regulating a contractile protein, bMHC, possibly by repressing translation of thyroid hormone receptor-associated protein 1 (THRAP1). other hsa-mir-21 Cardiomyopathy, Hypertrophic 17525252 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 Modulating miR-21 expression via antisense-mediated depletion (knockdown) had a significant negative effect on cardiomyocyte hypertrophy. other hsa-mir-21 Cardiomyopathy, Hypertrophic 28382463 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. other hsa-mir-23a Cardiomyopathy, Hypertrophic 20470752 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-23a:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth other hsa-mir-23a Cardiomyopathy, Hypertrophic 21464712 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy. other hsa-mir-23b Cardiomyopathy, Hypertrophic 28382463 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. other hsa-mir-24 Cardiomyopathy, Hypertrophic 28382463 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. other hsa-mir-27b Cardiomyopathy, Hypertrophic 20470752 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-27b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth other hsa-mir-9-1 Cardiomyopathy, Hypertrophic 20177053 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy other hsa-mir-9-2 Cardiomyopathy, Hypertrophic 20177053 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy other hsa-mir-9-3 Cardiomyopathy, Hypertrophic 20177053 cardiovascular system disease DOID:11984 I42.2 D002312 192600 HP:0001639 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy other hsa-mir-126 Cardiomyopathy, Ischemic 27866054 I25.5 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. other hsa-mir-155 Cardiomyopathy, Ischemic 27866054 I25.5 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. other hsa-mir-21 Cardiomyopathy, Ischemic 27666568 I25.5 Trimetazidine protects against cardiac ischemia/reperfusion injury via effects on cardiac miRNA‑21 expression, Akt and the Bcl‑2/Bax pathway. other hsa-mir-499 Cardiomyopathy, Ischemic 27866054 I25.5 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. other hsa-let-7a Cardiovascular Diseases [unspecific] 25759134 D002318 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-let-7b Cardiovascular Diseases [unspecific] 28159509 D002318 Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. other hsa-mir-100 Cardiovascular Diseases [unspecific] 25857370 D002318 In endothelial cells, activation of PPAR-δ decreased VLDL receptor expression and VLDL uptake via the induction of miR-100. These results provided a novel mechanism for the vascular protective effect of PPAR-δ agonists. other hsa-mir-10b Cardiovascular Diseases [unspecific] 27624142 D002318 Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients. other hsa-mir-126 Cardiovascular Diseases [unspecific] 25958013 D002318 This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes. other hsa-mir-126 Cardiovascular Diseases [unspecific] 23201405 D002318 Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes other hsa-mir-126 Cardiovascular Diseases [unspecific] 22215713 D002318 miRNA-126 levels were reduced in SHRs with an increase of 51% in phosphoinositol-3 kinase regulatory subunit 2 expression but normalized in SHR-Ts. other hsa-mir-126 Cardiovascular Diseases [unspecific] 24349482 D002318 miR-126 expression was depressed in the process of EPC EndMT. other hsa-mir-126 Cardiovascular Diseases [unspecific] 28253326 D002318 Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model. other hsa-mir-138 Cardiovascular Diseases [unspecific] 24486907 D002318 Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. other hsa-mir-143 Cardiovascular Diseases [unspecific] 25958013 D002318 This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes. other hsa-mir-143 Cardiovascular Diseases [unspecific] 22135162 D002318 MicroRNAs are critical for vascular smooth muscle cell differentiation and phenotype regulation, and miR-143 and miR-145 play a particularly important role in this respect. other hsa-mir-144 Cardiovascular Diseases [unspecific] 24642088 D002318 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144. other hsa-mir-145 Cardiovascular Diseases [unspecific] 26845891 D002318 THERAPEUTIC POTENTIAL OF MICRORNA IN THE FIELD OF CARDIOVASCULAR SURGERY. other hsa-mir-145 Cardiovascular Diseases [unspecific] 22135162 D002318 MicroRNAs are critical for vascular smooth muscle cell differentiation and phenotype regulation, and miR-143 and miR-145 play a particularly important role in this respect. other hsa-mir-146a Cardiovascular Diseases [unspecific] 25958013 D002318 This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes. other hsa-mir-155 Cardiovascular Diseases [unspecific] 24475727 D002318 The role of miRNA-155 in cardiovascular diseases other hsa-mir-155 Cardiovascular Diseases [unspecific] 28018919 D002318 a recent clinical trial of Miravirsen targeting microRNA-122 sheds light on exploiting microRNA-155 as a novel target to develop effective therapeutic strategies for cardiovascular diseases in the near future other hsa-mir-17 Cardiovascular Diseases [unspecific] 24386440 D002318 These findings revealed the role of miRNAs in h-ERG trafficking, which may contribute to the cardiac electrical disturbances associated with oxidative stress. other hsa-mir-17 Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-18 Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-188 Cardiovascular Diseases [unspecific] 19669742 D002318 These findings suggest that dicer and miRNAs especially miR-188 are involved in Hcy-induced cardiac remodeling other hsa-mir-199a-1 Cardiovascular Diseases [unspecific] 20458739 D002318 miR-199a is essential for the maintenance of cell size in cardiomyocytes other hsa-mir-199a-2 Cardiovascular Diseases [unspecific] 20458739 D002318 miR-199a is essential for the maintenance of cell size in cardiomyocytes other hsa-mir-19a Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-19b-1 Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-200c Cardiovascular Diseases [unspecific] 25759134 D002318 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-20a Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-21 Cardiovascular Diseases [unspecific] 25975660 D002318 miR-21 and cardiac fibrosis: another brick in the wall other hsa-mir-21 Cardiovascular Diseases [unspecific] 19043405 D002318 MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts other hsa-mir-21 Cardiovascular Diseases [unspecific] 20404348 D002318 MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand other hsa-mir-21 Cardiovascular Diseases [unspecific] 24447911 D002318 Ang II induced miR-21 expression in primary mouse cardiac fibroblasts (CFs) via ERK-dependent AP-1 and STAT3 activation, and while a miR-21 inhibitor reversed Ang II-induced RECK suppression, a miR-21 mimic inhibited both RECK expression and Ang II-induced CF migration. other hsa-mir-21 Cardiovascular Diseases [unspecific] 28418864 D002318 Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats. other hsa-mir-21 Cardiovascular Diseases [unspecific] 21712654 D002318 The small regulatory RNA microRNA-21 (miR-21) plays a crucial role in a plethora of biological functions and diseases including development, cancer, cardiovascular diseases and inflammation. other hsa-mir-21 Cardiovascular Diseases [unspecific] 21909994 D002318 This review highlights the complex roles that miRNA-21 plays in cancer and cardiovascular diseases and its potential clinical applications. other hsa-mir-21 Cardiovascular Diseases [unspecific] 23710745 D002318 MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-α induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway other hsa-mir-21 Cardiovascular Diseases [unspecific] 28465657 D002318 The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR) -induced VEGF expression in ARPE-19 cells under a hyperglycemic condition. other hsa-mir-21 Cardiovascular Diseases [unspecific] 29456377 D002318 the stability of both DIM and pre-miR-21 was found to be inversely correlated to each other in binding condition other hsa-mir-21 Cardiovascular Diseases [unspecific] 29659130 D002318 MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease other hsa-mir-210 Cardiovascular Diseases [unspecific] 27359286 D002318 miR-210 has also been shown to be associated with the development of different human diseases including various types of cancers, cardiovascular and cerebrovascular diseases, and immunological diseases. other hsa-mir-22 Cardiovascular Diseases [unspecific] 25218673 D002318 miR-22 in cardiac remodeling and disease. other hsa-mir-222 Cardiovascular Diseases [unspecific] 25863248 D002318 These studies implicate miR-222 as necessary for exercise-induced cardiomyocyte growth and proliferation in the adult mammalian heart and show that it is sufficient to protect the heart against adverse remodeling. other hsa-mir-222 Cardiovascular Diseases [unspecific] 28127557 D002318 MiR-222 in Cardiovascular Diseases: Physiology and Pathology. other hsa-mir-223 Cardiovascular Diseases [unspecific] 24657505 D002318 miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field. other hsa-mir-26 Cardiovascular Diseases [unspecific] 25066487 D002318 An emerging role for the miR-26 family in cardiovascular disease. other hsa-mir-29 Cardiovascular Diseases [unspecific] 27932253 D002318 Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis. other hsa-mir-29b Cardiovascular Diseases [unspecific] 27932253 D002318 Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis. other hsa-mir-30c Cardiovascular Diseases [unspecific] 29483230 D002318 Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. other hsa-mir-32 Cardiovascular Diseases [unspecific] 28319142 D002318 MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification. other hsa-mir-34 Cardiovascular Diseases [unspecific] 26559089 D002318 MicroRNA-34 Family and Its Role in Cardiovascular Disease. other hsa-mir-34a Cardiovascular Diseases [unspecific] 24438466 D002318 MicroRNA-34a: role in cancer and cardiovascular disease. other hsa-mir-34a Cardiovascular Diseases [unspecific] 20627091 D002318 MiR-34a:MicroRNA-34a regulation of endothelial senescence other hsa-mir-34a Cardiovascular Diseases [unspecific] 22651868 D002318 Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease. other hsa-mir-34a Cardiovascular Diseases [unspecific] 25887273 D002318 Also, miR-125a-5p/-351, miR-200c/-429, miR-106b/-17, miR-363/-92b, miR-181b/-181d, miR-19a/-19b, let-7d/-7f, miR-18a/-18b, miR-128/-27b and miR-106a/-291a-3p pairs exhibited significant synergy and their association to aging and/or cardiovascular diseases is supported in many cases by a disease database and previous studies. other hsa-mir-425 Cardiovascular Diseases [unspecific] 27132035 D002318 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo other hsa-mir-92-1 Cardiovascular Diseases [unspecific] 24212931 D002318 The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease. other hsa-mir-92a Cardiovascular Diseases [unspecific] 28696247 D002318 MicroRNA-92a Mediates Endothelial Dysfunction in CKD. other hsa-mir-92a Cardiovascular Diseases [unspecific] 27208561 D002318 PDW/miR-92a-score with a specificity of 97.5% and a sensitivity of 80.0% in relation to detect aspirin resistance. other hsa-mir-92a Cardiovascular Diseases [unspecific] 27936205 D002318 Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation. other hsa-mir-184 Cataract 29325388 nervous system disease DOID:83 H26.9 D002386 PS116200 HP:0000518 miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract other hsa-mir-1290 Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-17 Celiac Disease 28208686 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children. other hsa-mir-192 Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-194 Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-30a Celiac Disease 28208686 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children. other hsa-mir-31 Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-551a Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-551b Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-638 Celiac Disease 24063611 immune system disease DOID:10608 K90.0 D002446 PS212750 HP:0002608 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. other hsa-mir-134 Central Nervous System Embryonal Tumor 20622856 C72.9 D009373 miR-134:A novel pathway regulates memory and plasticity via SIRT1 and miR-134 other hsa-mir-221 Central Nervous System Embryonal Tumor 24832085 C72.9 D009373 Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors. other hsa-mir-222 Central Nervous System Embryonal Tumor 24832085 C72.9 D009373 Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors. other hsa-mir-29b Cerebral Aneurysm 28214880 cardiovascular system disease DOID:0060228 I67.1 D002532 PS105800 HP:0007029 MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. other hsa-let-7c Cerebral Ischemia 25934573 cardiovascular system disease DOID:2316 I67.82 D002545 HP:0002637 MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation. other hsa-mir-124-1 Cerebral Ischemia 23754622 cardiovascular system disease DOID:2316 I67.82 D002545 HP:0002637 MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. other hsa-mir-124-2 Cerebral Ischemia 23754622 cardiovascular system disease DOID:2316 I67.82 D002545 HP:0002637 MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. other hsa-mir-128 Cerebral Ischemia 27905005 cardiovascular system disease DOID:2316 I67.82 D002545 HP:0002637 MicroRNA-128-3p Protects Mouse Against Cerebral Ischemia Through Reducing p38α Mitogen-Activated Protein Kinase Activity. other hsa-mir-497 Cerebral Ischemia 27209189 cardiovascular system disease DOID:2316 I67.82 D002545 HP:0002637 amikacin inhibits miR-497 maturation and promotes ischemic neuronal survival by upregulating anti-apoptotic protein, bcl-2. other hsa-let-7a Cervical Neoplasms 25539644 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6. other hsa-mir-125b Cervical Neoplasms 28102867 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 Gene regulation of the DEGs also revealed important TFs and miRNAs such as ELF1, SRF, has-mir-125b-5p and has-mir-644a other hsa-mir-146a Cervical Neoplasms 23189617 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a other hsa-mir-15b Cervical Neoplasms 22920753 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 These data suggested that down-regulation of NDRG2 could enhance sensitivity of Hela cells to cisplatin through inhibiting Bcl-2 protein expression, which might be mediated by up-regulating miR-15b and miR-16. other hsa-mir-16 Cervical Neoplasms 22920753 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 These data suggested that down-regulation of NDRG2 could enhance sensitivity of Hela cells to cisplatin through inhibiting Bcl-2 protein expression, which might be mediated by up-regulating miR-15b and miR-16. other hsa-mir-200a Cervical Neoplasms 23679328 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. other hsa-mir-21 Cervical Neoplasms 25539644 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6. other hsa-mir-21 Cervical Neoplasms 28447761 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 miR-21 inhibitor suppresses cell proliferation and colony formation through regulating the PTEN/AKT pathway and improves paclitaxel sensitivity in cervical cancer cells. other hsa-mir-218 Cervical Neoplasms 23189617 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a other hsa-mir-29a Cervical Neoplasms 23189617 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a other hsa-mir-34a Cervical Neoplasms 21128241 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 In summary, our study demonstrates an intimate connection among oncogenic HPV E6,p53, miR-34a and p18Ink4c and identifies p18Ink4c as a possible biomarker for cervical cancer. other hsa-mir-34a Cervical Neoplasms 23189617 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a other hsa-mir-644a Cervical Neoplasms 28102867 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 Gene regulation of the DEGs also revealed important TFs and miRNAs such as ELF1, SRF, has-mir-125b-5p and has-mir-644a other hsa-mir-93 Cervical Neoplasms 23679328 disease of cellular proliferation DOID:4362 C53.9 D002583 603956 HP:0030159 MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. other hsa-mir-21 Cervicitis 26010154 reproductive system disease DOID:2568 N72 D002575 Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. other hsa-mir-200a Cervix Endometrial Stromal Tumor 24850415 disease of cellular proliferation DOID:4521 MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation. other hsa-mir-503 Chikungunya Virus Infection 24278205 disease by infectious agent DOID:0050012 A92.0 D065632 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. other hsa-mir-638 Chikungunya Virus Infection 24278205 disease by infectious agent DOID:0050012 A92.0 D065632 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. other hsa-mir-744 Chikungunya Virus Infection 24278205 disease by infectious agent DOID:0050012 A92.0 D065632 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. other hsa-mir-320a Childhood Leukemia 20807887 disease of cellular proliferation DOID:7757 In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression. other hsa-mir-494 Childhood Leukemia 20807887 disease of cellular proliferation DOID:7757 In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression. other hsa-mir-107 Childhood Obesity 24423308 E66.9 D063766 601665 Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.These changes have been causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease. other hsa-mir-33 Childhood Obesity 24423308 E66.9 D063766 601665 Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.These changes have been causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease. other hsa-mir-146a Chlamydial Infection 20011700 disease by infectious agent DOID:11263 A74.9 D002690 microRNA-146a is a negative regulator of Tolllike receptor (TLR) signaling other hsa-mir-106b Cholangiocarcinoma 29286255 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family other hsa-mir-138 Cholangiocarcinoma 23446431 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9. other hsa-mir-146a Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-155 Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-192 Cholangiocarcinoma 25131257 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 This finding indicates that elevated levels of miR-192 may be involved in CCA genesis and have a potential utility as a noninvasive prognostic indicator for CCA patients. other hsa-mir-199 Cholangiocarcinoma 25217977 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 the cell proliferation and inhibition of tumor suppression mediated by these miRNAs is common to both cancerous and non-cancerous cells. other hsa-mir-200a Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-200b Cholangiocarcinoma 24169343 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Our study shows that miR-200b/c has a critical role in the regulation of the tumorigenic and metastatic capacity of cholangiocarcinoma and reveals the probable underlying mechanisms. other hsa-mir-200b Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-200c Cholangiocarcinoma 22707408 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Inactivation of miR-200c resulted in an induction of EMT, whereas activation of miR-200c led to a reduction of EMT including a reduced cell migration and invasion in ICC cells. other hsa-mir-200c Cholangiocarcinoma 24169343 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Our study shows that miR-200b/c has a critical role in the regulation of the tumorigenic and metastatic capacity of cholangiocarcinoma and reveals the probable underlying mechanisms. other hsa-mir-21 Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-21 Cholangiocarcinoma 22213145 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Based on our data, we conclude that Ars2 is overexpressed in human CCA and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21. other hsa-mir-21 Cholangiocarcinoma 28197636 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 miR-21 and KLF4 jointly augment epithelial‑mesenchymal transition via the Akt/ERK1/2 pathway. other hsa-mir-221 Cholangiocarcinoma 24918778 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA. other hsa-mir-24 Cholangiocarcinoma 28087162 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation. other hsa-mir-30e Cholangiocarcinoma 29662654 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Extracellular vesicle-encapsulated miR-30e suppresses cholangiocarcinoma cell invasion and migration via inhibiting epithelial-mesenchymal transition other hsa-mir-494 Cholangiocarcinoma 22785131 disease of cellular proliferation DOID:4947 C22.1 D018281 615619 HP:0030153 Coordinated effects of microRNA-494 induce G/M arrest in human cholangiocarcinoma. other hsa-mir-130b Cholestasis 25802328 gastrointestinal system disease DOID:13580 K83.1 D002779 PS243300 These data support miR-130b as a potential negative regulator of drug metabolism by directly and/or indirectly affecting the expression of several ADME genes. This may be of relevance in pathophysiologic conditions such as cholestasis and inflammation, which are associated with increased miR-130b expression. other hsa-let-7a Cholesteatoma 25405753 integumentary system disease DOID:869 H71.9 D002781 604183 HP:0009797 reveal the crucial role of let-7a miRNA in the inhibition of growth and invasion of cholesteatoma keratinocytes. other hsa-mir-21 Cholesteatoma 25405753 integumentary system disease DOID:869 H71.9 D002781 604183 HP:0009797 reveal the crucial role of let-7a miRNA in the inhibition of growth and invasion of cholesteatoma keratinocytes. other hsa-mir-125b Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-129 Chondrosarcoma 28535514 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/β-Catenin Signaling Pathway. other hsa-mir-186 Chondrosarcoma 29730230 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 Resistin facilitates VEGF-C-associated lymphangiogenesis by inhibiting miR-186 in human chondrosarcoma cells. other hsa-mir-192 Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-206 Chondrosarcoma 27826039 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCδ pathway. other hsa-mir-20a Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-27b Chondrosarcoma 27252405 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells other hsa-mir-27b Chondrosarcoma 27345723 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 expression of microRNA-27b was negatively regulated by leptin other hsa-mir-490 Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-509 Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-550 Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-589 Chondrosarcoma 24178909 disease of cellular proliferation DOID:3371 M91-M94 D002813 215300 HP:0006765 mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line other hsa-mir-1-1 Chordoma 20041488 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 miR-1:miRNA-1 may have a functional effect on chordoma tumor pathogenesis other hsa-mir-1-2 Chordoma 20041488 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 miR-1:miRNA-1 may have a functional effect on chordoma tumor pathogenesis other hsa-mir-140 Chordoma 27016303 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression. other hsa-mir-148a Chordoma 27016303 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression. other hsa-mir-222 Chordoma 27016303 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression. other hsa-mir-31 Chordoma 23912551 musculoskeletal system disease DOID:3302 C41.0 D002817 215400 HP:0010762 MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. other hsa-mir-10b Choriocarcinoma 22682079 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 The role of miR-10b in metastatic pancreatic ductal adenocarcinoma. other hsa-mir-141 Choriocarcinoma 21726338 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 Reduction in miR-141 is induced by leukemia inhibitory factor and inhibits proliferation in choriocarcinoma cell line JEG-3. other hsa-mir-182 Choriocarcinoma 24078156 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage. other hsa-mir-194 Choriocarcinoma 24078156 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage. other hsa-mir-203 Choriocarcinoma 25486432 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 Besides EZH2, increases in miR-203 expression in the crypts at days 6 and 12 post infection correlated with reduced levels of its target WIF1; overexpression of miR-203 in primary colonocytes decreased WIF1 mRNA and protein levels. other hsa-mir-30d Choriocarcinoma 27481218 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 Following transient transfection of mir-30d mimic, the disrupted attachment and outgrowth of JAR spheroids was partially restored in the model. other hsa-mir-31 Choriocarcinoma 24078156 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage. other hsa-mir-34a Choriocarcinoma 23327670 disease of cellular proliferation DOID:3594 C58 D002822 HP:0100768 MiR-34a was either inhibited or ectopically expressed transiently in two choriocarcinoma cell lines (BeWo and JEG-3) respectively. other hsa-mir-211 Chromosome 15q13.3 Microdeletion Syndrome 27459725 genetic disease DOID:0060394 Q93.5 C567439 612001 The 15q13.3 microdeletion syndrome is caused by a 1.5-MB hemizygous microdeletion located on 15q13.3 affecting seven genes: FAN1; MTMR10; TRPM1; miR-211; KLF13; OTUD7A; and CHRNA7 other hsa-mir-145 Chromosome 5q Deletion Syndrome 26075044 hematopoietic system disease DOID:0090016 D46.7 153550 Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. other hsa-mir-146a Chromosome 5q Deletion Syndrome 26075044 hematopoietic system disease DOID:0090016 D46.7 153550 Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. other hsa-mir-126 Chronic Heart Failure 24958738 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression. other hsa-mir-133a-1 Chronic Heart Failure 19015276 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart other hsa-mir-133a-2 Chronic Heart Failure 19015276 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart other hsa-mir-21 Chronic Heart Failure 24958738 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression. other hsa-mir-214 Chronic Heart Failure 24958738 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression. other hsa-mir-221 Chronic Heart Failure 24958738 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression. other hsa-mir-222 Chronic Heart Failure 24958738 cardiovascular system disease DOID:6000 I50 D006333 HP:0001635 In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression. other hsa-mir-122 Chronic Hepatitis B 25788377 B18.0-.1 D019694 610424 Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection. other hsa-mir-15a Chronic Hepatitis B 28498453 B18.0-.1 D019694 610424 The inhibition of microRNA-15a suppresses hepatitis B virus-associated liver cancer cell growth through the Smad/TGF-β pathway. other hsa-mir-181a Chronic Hepatitis B 28053323 B18.0-.1 D019694 610424 HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN. other hsa-mir-210 Chronic Hepatitis B 24597695 B18.0-.1 D019694 610424 Studying the association of microRNA-210 level with chronic hepatitis B progression. other hsa-mir-224 Chronic Hepatitis B 27731343 B18.0-.1 D019694 610424 MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C. other hsa-mir-122 Chronic Hepatitis C 23808991 B18.2 D019698 609532 Serum microRNA-122 kinetics in patients with chronic hepatitis C virus infection during antiviral therapy. other hsa-mir-122 Chronic Hepatitis C 24270780 B18.2 D019698 609532 Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection. other hsa-mir-122 Chronic Hepatitis C 24270782 B18.2 D019698 609532 miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection. other hsa-mir-122 Chronic Hepatitis C 24672032 B18.2 D019698 609532 Reduction of microRNA 122 expression in IFNL3 CT/TT carriers and during progression of fibrosis in patients with chronic hepatitis C. other hsa-mir-122 Chronic Hepatitis C 26503793 B18.2 D019698 609532 We demonstrated a substantial and prolonged decrease in plasma miR-122 levels in patients dosed with miravirsen. Plasma levels of other miRNAs were not significantly affected by antagonising miR-122. other hsa-mir-122 Chronic Hepatitis C 24752012 B18.2 D019698 609532 HMOX1 and miR-122 play an important role in the pathogenesis of CHC in HCV mono-and HIV/HCV co-infected patients. Reduced expression of HMOX1 in patients with HIV/HCV co-infection may indicate a worse prognosis in this group. Our results do not support the importance of Bach-1 in repression of HMOX1 in patients with chronic hepatitis C. other hsa-mir-122 Chronic Hepatitis C 19085952 B18.2 D019698 609532 Moreover, CD56(+) T SN treatment inhibited the expression of HCV-supportive micro RNA (miRNA)-122 and enhanced the levels of anti-HCV miRNA-196a in human hepatocytes. other hsa-mir-122 Chronic Hepatitis C 27614072 B18.2 D019698 609532 TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. other hsa-mir-122 Chronic Hepatitis C 27805315 B18.2 D019698 609532 Inducing Hepatitis C Virus Resistance After Pig Liver Transplantation-A Proof of Concept of Liver Graft Modification Using Warm Ex Vivo Perfusion. other hsa-mir-122 Chronic Hepatitis C 28008821 B18.2 D019698 609532 Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5' untranslated region of hepatitis C virus RNA. other hsa-mir-122 Chronic Hepatitis C 28067225 B18.2 D019698 609532 Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. other hsa-mir-122 Chronic Hepatitis C 28087069 B18.2 D019698 609532 Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial. other hsa-mir-122 Chronic Hepatitis C 28295463 B18.2 D019698 609532 Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101. other hsa-mir-122 Chronic Hepatitis C 28389707 B18.2 D019698 609532 The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market. other hsa-mir-122 Chronic Hepatitis C 28442604 B18.2 D019698 609532 Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. other hsa-mir-122 Chronic Hepatitis C 28456022 B18.2 D019698 609532 Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA. other hsa-mir-122 Chronic Hepatitis C 28494029 B18.2 D019698 609532 Characterization of miR-122-independent propagation of HCV. other hsa-mir-122 Chronic Hepatitis C 28642978 B18.2 D019698 609532 Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin. other hsa-mir-122 Chronic Hepatitis C 28844749 B18.2 D019698 609532 Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing. other hsa-mir-122 Chronic Hepatitis C 29084265 B18.2 D019698 609532 miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. other hsa-mir-122 Chronic Hepatitis C 29327233 B18.2 D019698 609532 DCAF1 is involved in HCV replication through regulation of miR-122 and thus provides new insights into the interaction between HCV and the host cell other hsa-mir-122 Chronic Hepatitis C 29343570 B18.2 D019698 609532 the 5'-proximal EHcV-specific region enhances viral replication and RNA stability in a miR-122-independent manner other hsa-mir-122 Chronic Hepatitis C 29486652 B18.2 D019698 609532 Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges other hsa-mir-122 Chronic Hepatitis C 29672716 B18.2 D019698 609532 miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11 other hsa-mir-155 Chronic Hepatitis C 27765085 B18.2 D019698 609532 Differential Expression of MicroRNAs in Hepatitis C Virus-Mediated Liver Disease Between African Americans and Caucasians: Implications for Racial Health Disparities. other hsa-mir-196a Chronic Hepatitis C 19085952 B18.2 D019698 609532 Moreover, CD56(+) T SN treatment inhibited the expression of HCV-supportive micro RNA (miRNA)-122 and enhanced the levels of anti-HCV miRNA-196a in human hepatocytes. other hsa-mir-223 Chronic Hepatitis C 28864162 B18.2 D019698 609532 Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9. other hsa-mir-224 Chronic Hepatitis C 27731343 B18.2 D019698 609532 MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C. other hsa-mir-24 Chronic Hepatitis C 28864162 B18.2 D019698 609532 Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9. other hsa-mir-30a Chronic Hepatitis C 27591428 B18.2 D019698 609532 miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models. other hsa-mir-99a Chronic Hepatitis C 25844942 B18.2 D019698 609532 IFI35, mir-99a and HCV genotype to predict sustained virological response to pegylated-interferon plus ribavirin in chronic hepatitis C. other hsa-mir-146a Chronic Inflammation 23705069 MicroRNA-146a (miR-146a) is a critical negative regulator of inflammation other hsa-mir-148a Chronic Inflammation 25486906 Twist1 and T-bet not only control the differentiation and function of Th1 cells, but also their persistence in chronic inflammation. other hsa-mir-34a Chronic Inflammation 29773953 miR-34a-mediated regulation of XIST in female cells under inflammation. other hsa-mir-21 Chronic Kidney Disease 27610006 urinary system disease DOID:784 N18.9 D007676 HP:0012622 TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation. other hsa-mir-1 Chronic Obstructive Pulmonary Disease 28025995 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. other hsa-mir-132 Chronic Obstructive Pulmonary Disease 26807508 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Ectopic expression of PKR or miR-132 antagomiR alone failed to restore IFN-尾 induction, whereas cotreatment increased antiviral stress granule formation, induction of p300, and IFN-尾 in COPD pBECs. other hsa-mir-149 Chronic Obstructive Pulmonary Disease 28260877 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD. other hsa-mir-15a Chronic Obstructive Pulmonary Disease 28025995 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. other hsa-mir-16 Chronic Obstructive Pulmonary Disease 28025995 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. other hsa-mir-196a-2 Chronic Obstructive Pulmonary Disease 27043015 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Association of MicroRNA-196a2 Variant with Response to Short-Acting β2-Agonist in COPD: An Egyptian Pilot Study. other hsa-mir-21 Chronic Obstructive Pulmonary Disease 29543496 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy other hsa-mir-23a Chronic Obstructive Pulmonary Disease 28025995 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. other hsa-mir-34 Chronic Obstructive Pulmonary Disease 26191210 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 These proofs suggest that resveratrol inhibited dysfunction of dendritic cells (DCs) from COPD patients through promoting miR-34. other hsa-mir-9 Chronic Obstructive Pulmonary Disease 28025995 respiratory system disease DOID:3083 J44.9 D029424 606963 HP:0006510 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. other hsa-mir-212 Cocaine Abuse 20613834 disease of mental health DOID:809 F14.1 D019970 miR-212:miR-212 signalling has a key role in determining vulnerability to cocaine addiction other hsa-mir-212 Cocaine Abuse 20711185 disease of mental health DOID:809 F14.1 D019970 miR-212:miR-212 in dorsal striatum may be important in regulating vulnerability to cocaine addiction other hsa-mir-146b Colitis 23071818 gastrointestinal system disease DOID:0060180 K52.9 D003092 191390 HP:0002583 our data indicates that miRNA-146b and PPARγ activation may be implicated in the regulation of Th17 responses and colitis in C. difficile-infected mice. other hsa-mir-155 Colitis 21880981 gastrointestinal system disease DOID:0060180 K52.9 D003092 191390 HP:0002583 MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis. other hsa-mir-200b Colitis 28370348 gastrointestinal system disease DOID:0060180 K52.9 D003092 191390 HP:0002583 miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition. other hsa-mir-124 Colitis, Ulcerative 24825593 gastrointestinal system disease DOID:8577 K51 D003093 attenuation of ischemic and inflammatory injury in cardiomyocytes. other hsa-mir-126 Colitis, Ulcerative 27061150 gastrointestinal system disease DOID:8577 K51 D003093 mango polyphenols attenuated inflammatory response by modulating the PI3K/AKT/mTOR pathway at least in part through upregulation of miRNA-126 expression both in vitro and in vivo other hsa-mir-146a Colitis, Ulcerative 26730791 gastrointestinal system disease DOID:8577 K51 D003093 Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC. other hsa-mir-155 Colitis, Ulcerative 26730791 gastrointestinal system disease DOID:8577 K51 D003093 Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC. other hsa-mir-16 Colitis, Ulcerative 26440311 gastrointestinal system disease DOID:8577 K51 D003093 miR-16 suppression during the colitis-to-cancer sequence in colon epithelial cells, which was rescued by drinking Cl-amidine. other hsa-mir-200 Colitis, Ulcerative 28288169 gastrointestinal system disease DOID:8577 K51 D003093 The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients. other hsa-mir-21 Colitis, Ulcerative 26730791 gastrointestinal system disease DOID:8577 K51 D003093 Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC. other hsa-mir-21 Colitis, Ulcerative 27824649 gastrointestinal system disease DOID:8577 K51 D003093 Downregulation of MicroRNA-21 in Colonic CD3+ T Cells in UC Remission. other hsa-mir-941-1 Colitis, Ulcerative 22359580 gastrointestinal system disease DOID:8577 K51 D003093 UC susceptibility other hsa-mir-941-3 Colitis, Ulcerative 22359580 gastrointestinal system disease DOID:8577 K51 D003093 UC susceptibility other hsa-mir-941-4 Colitis, Ulcerative 22359580 gastrointestinal system disease DOID:8577 K51 D003093 UC susceptibility other hsa-mir-204 Coloboma 26056285 nervous system disease DOID:12270 Q13.0 D003103 120200 MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma. other hsa-let-7a Colon Neoplasms 25330373 D12.6 D003110 HP:0100273 63 miRNA are selectively enriched in the EVs--miR-19a/b-3p, miR-378a/c/d, and miR-577 and members of the let-7 and miR-8 families being the most prominent. other hsa-let-7c Colon Neoplasms 18188765 D12.6 D003110 HP:0100273 Let-7C was clearly present in lung, prostate, and colon cancers but undetectable in ovary and thyroid cancer samples other hsa-let-7f Colon Neoplasms 25330373 D12.6 D003110 HP:0100273 63 miRNA are selectively enriched in the EVs--miR-19a/b-3p, miR-378a/c/d, and miR-577 and members of the let-7 and miR-8 families being the most prominent. other hsa-let-7g Colon Neoplasms 18172508 D12.6 D003110 HP:0100273 Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer. other hsa-let-7i Colon Neoplasms 29588449 D12.6 D003110 HP:0100273 Available gene expression data allowed us to associate miR-30b expression with axon guidance and let-7i expression with cell adhesion, migration, and motility other hsa-mir-101-1 Colon Neoplasms 19133256 D12.6 D003110 HP:0100273 miR-101: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression other hsa-mir-101-1 Colon Neoplasms 22353936 D12.6 D003110 HP:0100273 MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers. other hsa-mir-101-2 Colon Neoplasms 19133256 D12.6 D003110 HP:0100273 miR-101: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression other hsa-mir-101-2 Colon Neoplasms 22353936 D12.6 D003110 HP:0100273 MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers. other hsa-mir-106b Colon Neoplasms 21283757 D12.6 D003110 HP:0100273 Butyrate-induced p21 protein expression was dampened by treatment with a miR-106b mimic. other hsa-mir-1-1 Colon Neoplasms 22179665 D12.6 D003110 HP:0100273 MIR-1 DOWNREGULATION COOPERATES WITH MACC1 IN PROMOTING MET OVEREXPRESSION IN HUMAN COLON CANCER. other hsa-mir-125a Colon Neoplasms 23327190 D12.6 D003110 HP:0100273 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer other hsa-mir-125b-1 Colon Neoplasms 23327190 D12.6 D003110 HP:0100273 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer other hsa-mir-125b-2 Colon Neoplasms 23327190 D12.6 D003110 HP:0100273 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer other hsa-mir-126 Colon Neoplasms 18663744 D12.6 D003110 HP:0100273 miR-126: miR-126 suppresses the growth of neoplastic cells other hsa-mir-1290 Colon Neoplasms 23142292 D12.6 D003110 HP:0100273 Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells other hsa-mir-130a Colon Neoplasms 29225578 D12.6 D003110 HP:0100273 Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a other hsa-mir-140 Colon Neoplasms 19734943 D12.6 D003110 HP:0100273 high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts other hsa-mir-143 Colon Neoplasms 14573789 D12.6 D003110 HP:0100273 reduced miRNA levels other hsa-mir-143 Colon Neoplasms 21276449 D12.6 D003110 HP:0100273 The ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. other hsa-mir-143 Colon Neoplasms 21653642 D12.6 D003110 HP:0100273 EGFR suppresses miR-143 and miR-145 in murine models of colon cancer. Furthermore, Western diet unmasks the tumor suppressor roles of these EGFR-regulated miRNAs. other hsa-mir-143 Colon Neoplasms 26025964 D12.6 D003110 HP:0100273 The data also showed that the restoration of hsa-miR-143 expression in SW480 leads to a significant translation repression of the introduced reporter and suicide genes. other hsa-mir-143 Colon Neoplasms 26824186 D12.6 D003110 HP:0100273 miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells other hsa-mir-143 Colon Neoplasms 29360852 D12.6 D003110 HP:0100273 miR-143 might circumvent resistance of colon cancer cells to oxaliplatin via increased oxidative stress in HCT116 human colon cancer cells other hsa-mir-145 Colon Neoplasms 14573789 D12.6 D003110 HP:0100273 reduced miRNA levels other hsa-mir-145 Colon Neoplasms 18676867 D12.6 D003110 HP:0100273 miR-145: miR-145 potently suppressed growth of three different colon carcinoma cell lines other hsa-mir-145 Colon Neoplasms 21653642 D12.6 D003110 HP:0100273 EGFR suppresses miR-143 and miR-145 in murine models of colon cancer. Furthermore, Western diet unmasks the tumor suppressor roles of these EGFR-regulated miRNAs. other hsa-mir-145 Colon Neoplasms 26824186 D12.6 D003110 HP:0100273 miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells other hsa-mir-155 Colon Neoplasms 23036199 D12.6 D003110 HP:0100273 Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155 other hsa-mir-15a Colon Neoplasms 22574716 D12.6 D003110 HP:0100273 Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo. other hsa-mir-15b Colon Neoplasms 24892299 D12.6 D003110 HP:0100273 Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. other hsa-mir-16-1 Colon Neoplasms 22574716 D12.6 D003110 HP:0100273 Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo. other hsa-mir-16-1 Colon Neoplasms 23308284 D12.6 D003110 HP:0100273 The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest other hsa-mir-16-2 Colon Neoplasms 23308284 D12.6 D003110 HP:0100273 The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest other hsa-mir-17 Colon Neoplasms 22677902 D12.6 D003110 HP:0100273 miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. other hsa-mir-181b Colon Neoplasms 18172508 D12.6 D003110 HP:0100273 Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer. other hsa-mir-1915 Colon Neoplasms 24814047 D12.6 D003110 HP:0100273 Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. other hsa-mir-192 Colon Neoplasms 19074875 D12.6 D003110 HP:0100273 Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest. other hsa-mir-19a Colon Neoplasms 22677902 D12.6 D003110 HP:0100273 miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. other hsa-mir-19a Colon Neoplasms 23666757 D12.6 D003110 HP:0100273 MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. other hsa-mir-203 Colon Neoplasms 28431272 D12.6 D003110 HP:0100273 Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6. other hsa-mir-21 Colon Neoplasms 21279518 D12.6 D003110 HP:0100273 PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis. other hsa-mir-21 Colon Neoplasms 22677902 D12.6 D003110 HP:0100273 miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer. other hsa-mir-21 Colon Neoplasms 23544170 D12.6 D003110 HP:0100273 Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens other hsa-mir-21 Colon Neoplasms 26853468 D12.6 D003110 HP:0100273 a DHA-enriched diet induced a decrease of human miR-21 expression and an increase of human TNF伪 mRNA expression limiting tumor growth in a cancer cell-derived TNF伪 dependent manner. other hsa-mir-21 Colon Neoplasms 28176652 D12.6 D003110 HP:0100273 Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation. other hsa-mir-21 Colon Neoplasms 17702597 D12.6 D003110 HP:0100273 In colon cancer cells, at a clinically relevant concentration,the drug up-regulates or down-regulates in vitro the expression of 19 and 3 miR genes, respectively, by a factor of not less than two-fold. In some instances, 5-FU up-regulates miR genes that are already over-expressed in neoplastic tissues, including, for example, miR-21 that is associated with anti-apoptotic functions characterizing malignant cells. other hsa-mir-215 Colon Neoplasms 19074875 D12.6 D003110 HP:0100273 Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest. other hsa-mir-22 Colon Neoplasms 22328083 D12.6 D003110 HP:0100273 MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. other hsa-mir-223 Colon Neoplasms 23584479 D12.6 D003110 HP:0100273 Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells. other hsa-mir-23b Colon Neoplasms 22109528 D12.6 D003110 HP:0100273 Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. other hsa-mir-29b Colon Neoplasms 29545333 D12.6 D003110 HP:0100273 A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells other hsa-mir-302b Colon Neoplasms 22384170 D12.6 D003110 HP:0100273 Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells. other hsa-mir-30b Colon Neoplasms 29588449 D12.6 D003110 HP:0100273 Available gene expression data allowed us to associate miR-30b expression with axon guidance and let-7i expression with cell adhesion, migration, and motility other hsa-mir-31 Colon Neoplasms 21062447 D12.6 D003110 HP:0100273 Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells. other hsa-mir-31 Colon Neoplasms 27926494 D12.6 D003110 HP:0100273 p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription. other hsa-mir-34a Colon Neoplasms 20433755 D12.6 D003110 HP:0100273 For instance, miR-34a up-regulation corresponded with a down-regulation of BCL2 protein. Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU. other hsa-mir-449a Colon Neoplasms 28878284 D12.6 D003110 HP:0100273 MicroRNA-449a deficiency promotes colon carcinogenesis. other hsa-mir-455 Colon Neoplasms 27861461 D12.6 D003110 HP:0100273 MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells. other hsa-mir-493 Colon Neoplasms 22373578 D12.6 D003110 HP:0100273 miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. other hsa-mir-498 Colon Neoplasms 18676867 D12.6 D003110 HP:0100273 miR-498: correlated with the probability of recurrence-free survival other hsa-mir-502 Colon Neoplasms 22580605 D12.6 D003110 HP:0100273 Inhibition of autophagy and tumor growth in colon cancer by miR-502. other hsa-mir-627 Colon Neoplasms 27458137 D12.6 D003110 HP:0100273 In addition, overexpression of miR-627 or siRNA knockdown of CYP3A4 enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction. other hsa-mir-92a-1 Colon Neoplasms 21883694 D12.6 D003110 HP:0100273 miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer other hsa-mir-126 Colorectal Adenocarcinoma 23996930 disease of cellular proliferation DOID:0050861 C19 C000599423 114500 Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. other hsa-mir-145 Colorectal Adenocarcinoma 24938624 disease of cellular proliferation DOID:0050861 C19 C000599423 114500 This might be attributable to the fact that effects of miRNA activity may oscillate between gene product repression and activation. other hsa-mir-182 Colorectal Adenocarcinoma 24615484 disease of cellular proliferation DOID:0050861 C19 C000599423 114500 The increased levels of the oncogene-like miR-182 increase the risk for disease progression and predict poor overall survival for colorectal adenocarcinoma patients. other hsa-mir-21 Colorectal Adenocarcinoma 24938624 disease of cellular proliferation DOID:0050861 C19 C000599423 114500 This might be attributable to the fact that effects of miRNA activity may oscillate between gene product repression and activation. other hsa-mir-21 Colorectal Adenocarcinoma 29512659 disease of cellular proliferation DOID:0050861 C19 C000599423 114500 An amplification-free electrochemical detection of exosomal miRNA-21 in serum samples other hsa-mir-15a Colorectal Adenoma 26148070 disease of cellular proliferation DOID:0050860 Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression. other hsa-let-7b Colorectal Carcinoma 25611389 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. other hsa-mir-100 Colorectal Carcinoma 26132860 disease of cellular proliferation DOID:0080199 C19 D015179 114500 These findings suggest that extracellular miRNAs can function in target cells and uncover a potential new mode of action for mutant KRAS in CRC. other hsa-mir-101 Colorectal Carcinoma 26071354 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells. other hsa-mir-106a Colorectal Carcinoma 23950216 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Fecal miR-106a is a good molecular marker to identify colorectal cancer patients from among those with negative iFOBT results. FmiRT combined with iFOBT may improve the sensitivity to detect colorectal cancer. other hsa-mir-106a Colorectal Carcinoma 28693239 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Biological effects and clinical characteristics of microRNA-106a in human colorectal cancer other hsa-mir-106b Colorectal Carcinoma 26238857 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. other hsa-mir-106b Colorectal Carcinoma 26617763 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Taken together, these findings demonstrated that miR-106b knockdown could induce EMT which conferring cells migratory and invasive properties but could not accomplish distant metastatic colonization efficiently. other hsa-mir-107 Colorectal Carcinoma 25197016 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MiR-107 and miR-99a-3p were validated as predictors of response to standard fluoropyrimidine-based chemotherapy in patients with mCRC. other hsa-mir-10b Colorectal Carcinoma 25606801 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-10b is potentially involved in the invasion of colorectal cancer. other hsa-mir-124 Colorectal Carcinoma 24909917 disease of cellular proliferation DOID:0080199 C19 D015179 114500 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. other hsa-mir-124 Colorectal Carcinoma 25818238 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. other hsa-mir-1288 Colorectal Carcinoma 24009195 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance. other hsa-mir-1292 Colorectal Carcinoma 28054337 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. other hsa-mir-1307 Colorectal Carcinoma 25977444 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment. other hsa-mir-130b Colorectal Carcinoma 24027433 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. other hsa-mir-130b Colorectal Carcinoma 24204200 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. other hsa-mir-132 Colorectal Carcinoma 24914372 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Our study indicated that miR-132 plays an important role in the invasion and metastasis of CRC. other hsa-mir-133a Colorectal Carcinoma 25104873 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The clinicopathological significance of miR-133a in colorectal cancer. other hsa-mir-133a Colorectal Carcinoma 24464560 disease of cellular proliferation DOID:0080199 C19 D015179 114500 DSS-induced chronic inflammation downregulates miR-133a and miR-143/145, which is reportedly associated with human colorectal cancer and PI3K/Akt activation. other hsa-mir-133b Colorectal Carcinoma 28098895 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. other hsa-mir-134 Colorectal Carcinoma 26897940 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Decreased Expression of MIR-134 and its Clinical Significance in Human Colorectal Cancer. other hsa-mir-138 Colorectal Carcinoma 26316117 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of miR-138 as a Contributing Mechanism to Lcn-2 Overexpression in Colorectal Cancer with Liver Metastasis. other hsa-mir-139 Colorectal Carcinoma 24942287 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. other hsa-mir-139 Colorectal Carcinoma 25286864 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer. other hsa-mir-139 Colorectal Carcinoma 27173050 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. other hsa-mir-140 Colorectal Carcinoma 25980495 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy. other hsa-mir-141 Colorectal Carcinoma 26179333 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. other hsa-mir-143 Colorectal Carcinoma 25474488 disease of cellular proliferation DOID:0080199 C19 D015179 114500 a role of the miR-143/145 cluster as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. other hsa-mir-143 Colorectal Carcinoma 26392389 disease of cellular proliferation DOID:0080199 C19 D015179 114500 These findings warrant further studies to investigate the relationship between miR-143, FXYD3 and fluoropyrimidines, and the clinical utility of miR-143 as biomarker. other hsa-mir-143 Colorectal Carcinoma 19843160 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Collectively, the data obtained in the present study suggest anti-proliferative, chemosensitizer and putative pro-apoptotic roles for miR-143 in colon cancer. other hsa-mir-143 Colorectal Carcinoma 22751122 disease of cellular proliferation DOID:0080199 C19 D015179 114500 These results establish a complex network of regulation through which the miR-143/145 cluster is able to modulate KRAS signaling in colorectal cancer. other hsa-mir-143 Colorectal Carcinoma 27629291 disease of cellular proliferation DOID:0080199 C19 D015179 114500 we showed the importance of interactions between TP53, miR-143, KRAS, BCL2, and PLK1 with respect to colorectal cancer using bioinformatics approach other hsa-mir-143 Colorectal Carcinoma 19843336 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In vitro functional studies indicated that miR-143 and miR-145 appear to function in opposing manners to either inhibit or augment cell proliferation in a metastatic CRC model. other hsa-mir-145 Colorectal Carcinoma 25474488 disease of cellular proliferation DOID:0080199 C19 D015179 114500 a role of the miR-143/145 cluster as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. other hsa-mir-145 Colorectal Carcinoma 22751122 disease of cellular proliferation DOID:0080199 C19 D015179 114500 These results establish a complex network of regulation through which the miR-143/145 cluster is able to modulate KRAS signaling in colorectal cancer. other hsa-mir-145 Colorectal Carcinoma 29404790 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC other hsa-mir-145 Colorectal Carcinoma 19843336 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In vitro functional studies indicated that miR-143 and miR-145 appear to function in opposing manners to either inhibit or augment cell proliferation in a metastatic CRC model. other hsa-mir-146a Colorectal Carcinoma 24576899 disease of cellular proliferation DOID:0080199 C19 D015179 114500 A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. other hsa-mir-146a Colorectal Carcinoma 27580100 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Numb is involved in the non-random segregation of subcellular vesicles in colorectal cancer stem cells. other hsa-mir-146a Colorectal Carcinoma 27769860 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells. other hsa-mir-148a Colorectal Carcinoma 23933284 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Clinical significance of microRNA-148a in patients with early relapse of stage II stage and III colorectal cancer after curative resection. other hsa-mir-148b Colorectal Carcinoma 24632606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. other hsa-mir-150 Colorectal Carcinoma 25924769 disease of cellular proliferation DOID:0080199 C19 D015179 114500 We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups. other hsa-mir-152 Colorectal Carcinoma 28098901 disease of cellular proliferation DOID:0080199 C19 D015179 114500 after treatment with berberine and evodiamine for 24 h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted other hsa-mir-153 Colorectal Carcinoma 23950211 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance. other hsa-mir-155 Colorectal Carcinoma 27176480 disease of cellular proliferation DOID:0080199 C19 D015179 114500 S100A8 activated the NF-魏B pathway in the macrophages and promoted the expression of miR-155 other hsa-mir-16 Colorectal Carcinoma 24895601 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC. other hsa-mir-16 Colorectal Carcinoma 27055667 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Prodigiosin caused a significant increase in miRNA-16-1 expression other hsa-mir-17 Colorectal Carcinoma 26215320 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Calycosin induces apoptosis by the regulation of ERβ/miR-17 signaling pathway in human colorectal cancer cells. other hsa-mir-182 Colorectal Carcinoma 25755709 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Fentanyl also downregulated the expression of 尾-catenin and miR-182 in both xenograft tumors and HCT116 cells other hsa-mir-18a Colorectal Carcinoma 25379703 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. other hsa-mir-19 Colorectal Carcinoma 25934693 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer. other hsa-mir-194 Colorectal Carcinoma 28280361 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-194 modulates epithelial-mesenchymal transition in human colorectal cancer metastasis. other hsa-mir-195 Colorectal Carcinoma 28255246 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. other hsa-mir-195 Colorectal Carcinoma 28356122 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer. other hsa-mir-196a-2 Colorectal Carcinoma 24107909 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer. other hsa-mir-199a Colorectal Carcinoma 26065676 disease of cellular proliferation DOID:0080199 C19 D015179 114500 It was found that miR-199a would reduce the proliferation, migration and invasion. However, overexpression of miR-199a on the apoptosis rate and cell cycles showed no significant results. The potential functionary mechanism of miR-199a might through HIF-1α/VEGF pathway. other hsa-mir-19a Colorectal Carcinoma 26302825 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Collectively, miR-19a played an important role in mediating EMT and metastatic behavior in CRC. It may serve as a potential marker of lymph node metastasis. other hsa-mir-200 Colorectal Carcinoma 24376848 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The role of microRNA-200 in progression of human colorectal and breast cancer. other hsa-mir-200b Colorectal Carcinoma 28899657 disease of cellular proliferation DOID:0080199 C19 D015179 114500 HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells. other hsa-mir-200c Colorectal Carcinoma 26179333 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. other hsa-mir-200c Colorectal Carcinoma 27918105 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Resveratrol Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition by Increasing miR-200c Expression in HCT-116 Colorectal Cancer Cells. other hsa-mir-200c Colorectal Carcinoma 28745318 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity. other hsa-mir-200c Colorectal Carcinoma 28567416 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Negative Correlation between miR-200c and Decorin Plays an Important Role in the Pathogenesis of Colorectal Carcinoma. other hsa-mir-203 Colorectal Carcinoma 27236538 disease of cellular proliferation DOID:0080199 C19 D015179 114500 overexpression of miR-203 sensitizes colon cancer cells other hsa-mir-204 Colorectal Carcinoma 25294901 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Our results demonstrate for the first time that miR-204-5p acts as a tumor suppressor in colorectal cancer through inhibiting RAB22A and reveal RAB22A to be a new oncogene and prognostic factor for colorectal cancer. other hsa-mir-204 Colorectal Carcinoma 27571956 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. other hsa-mir-205 Colorectal Carcinoma 26183718 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. other hsa-mir-20a Colorectal Carcinoma 29404790 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC other hsa-mir-21 Colorectal Carcinoma 22281474 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Aging and DMH are associated with increases in CSLC biomarkers and miR21, each of which have been linked to colorectal cancer. other hsa-mir-21 Colorectal Carcinoma 23788041 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression. other hsa-mir-21 Colorectal Carcinoma 23858763 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Construction of microRNA-21 and PTEN eukaryotic expression and short hairpin RNA expression vectors other hsa-mir-21 Colorectal Carcinoma 24780321 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. other hsa-mir-21 Colorectal Carcinoma 24832083 disease of cellular proliferation DOID:0080199 C19 D015179 114500 nuclear translocation of β-catenin increased by miR-21 promotes tumour malignancy and a poor outcome in APC-mutated patients but not in APC-wild-type colorectal cancer. other hsa-mir-21 Colorectal Carcinoma 25178983 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Circulating miR21 level has potential value for colorectal cancer early detection, whereas high tissue miR21 level is associated with adverse colorectal cancer prognosis. other hsa-mir-21 Colorectal Carcinoma 26184038 disease of cellular proliferation DOID:0080199 C19 D015179 114500 IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b. other hsa-mir-21 Colorectal Carcinoma 27349026 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Plasma Expression Levels of Circulating miR-21 are not Useful for Diagnosing and Monitoring Colorectal Cancer. other hsa-mir-21 Colorectal Carcinoma 29404790 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC other hsa-mir-21 Colorectal Carcinoma 28192117 disease of cellular proliferation DOID:0080199 C19 D015179 114500 NR2F2 inhibits Smad7 expression and promotes TGF-β-dependent epithelial-mesenchymal transition of CRC via transactivation of miR-21. other hsa-mir-21 Colorectal Carcinoma 28236743 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy other hsa-mir-21 Colorectal Carcinoma 28401648 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer. other hsa-mir-21 Colorectal Carcinoma 29456985 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Evaluation of miR-21 Inhibition and its Impact on Cancer Susceptibility Candidate 2 Long Noncoding RNA in Colorectal Cancer Cell Line other hsa-mir-21 Colorectal Carcinoma 26712035 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-21 followed by miR-34, miR-200 and miR-215 are the most reported miRNAs to have roles in colon CSC regulation. other hsa-mir-210 Colorectal Carcinoma 24632577 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. other hsa-mir-211 Colorectal Carcinoma 26974151 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer. other hsa-mir-214 Colorectal Carcinoma 24616020 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. other hsa-mir-215 Colorectal Carcinoma 28006930 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Systemic administration of miRNA mimics by liposomal delivery system in animal model of colorectal carcinoma. other hsa-mir-215 Colorectal Carcinoma 26712035 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-21 followed by miR-34, miR-200 and miR-215 are the most reported miRNAs to have roles in colon CSC regulation. other hsa-mir-221 Colorectal Carcinoma 23770133 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In metastatic CRC cells, reduced levels of mir-221* and mir-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin. Increased activities of mir-221* and mir-224 reduce growth and metastasis of CRC xenograft tumors in mice; these mirs might be developed as therapeutic reagents or biomarkers of CRC progression. other hsa-mir-223 Colorectal Carcinoma 24841830 disease of cellular proliferation DOID:0080199 C19 D015179 114500 fecal miR-223 and miR-451 hold promise in detecting CRC. other hsa-mir-223 Colorectal Carcinoma 24819398 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-223 functions as an oncogene in human colorectal cancer cells. other hsa-mir-224 Colorectal Carcinoma 23770133 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In metastatic CRC cells, reduced levels of mir-221* and mir-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin. Increased activities of mir-221* and mir-224 reduce growth and metastasis of CRC xenograft tumors in mice; these mirs might be developed as therapeutic reagents or biomarkers of CRC progression. other hsa-mir-224 Colorectal Carcinoma 25919696 disease of cellular proliferation DOID:0080199 C19 D015179 114500 We describe a novel mechanism of KRAS regulation, and highlight the clinical utility of colorectal cancer-specific miRNAs as disease progression or clinical response biomarkers. other hsa-mir-224 Colorectal Carcinoma 26822534 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Our research showed mechanistic links between miR-224 and Wnt/β-catenin in the pathogenesis of CRC through modulation of GSK3β and SFRP2. other hsa-mir-23a Colorectal Carcinoma 24249161 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells. other hsa-mir-26a Colorectal Carcinoma 26494299 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. other hsa-mir-26b Colorectal Carcinoma 26308439 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Clinical Value of miR-26b Discriminating Ulcerative Colitis-associated Colorectal Cancer in the Subgroup of Patients with Metastatic Disease. other hsa-mir-27a Colorectal Carcinoma 24909917 disease of cellular proliferation DOID:0080199 C19 D015179 114500 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. other hsa-mir-27a Colorectal Carcinoma 25712055 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. other hsa-mir-29a Colorectal Carcinoma 26782449 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis. other hsa-mir-29a Colorectal Carcinoma 28098901 disease of cellular proliferation DOID:0080199 C19 D015179 114500 after treatment with berberine and evodiamine for 24 h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted other hsa-mir-29b Colorectal Carcinoma 26184038 disease of cellular proliferation DOID:0080199 C19 D015179 114500 IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b. other hsa-mir-30b Colorectal Carcinoma 24909917 disease of cellular proliferation DOID:0080199 C19 D015179 114500 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. other hsa-mir-31 Colorectal Carcinoma 24242331 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway. other hsa-mir-31 Colorectal Carcinoma 27082577 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. other hsa-mir-31 Colorectal Carcinoma 25543122 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Overexpression of miR-31 and -182 in CRC leads to more aggressive cancer. other hsa-mir-31 Colorectal Carcinoma 26871294 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In conclusion, an inverse association was identified between EZH2 and miR-31 in colorectal cancers. other hsa-mir-320a Colorectal Carcinoma 25458952 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-320b may function in competing with microRNA-320a. Thus, our study has proposed one novel mechanism for controlling colorectal cancer proliferation and invasion through homologous competition between microRNAs. This mechanism may be important for colorectal cancer metastasis. other hsa-mir-320b Colorectal Carcinoma 25458952 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-320b may function in competing with microRNA-320a. Thus, our study has proposed one novel mechanism for controlling colorectal cancer proliferation and invasion through homologous competition between microRNAs. This mechanism may be important for colorectal cancer metastasis. other hsa-mir-320e Colorectal Carcinoma 26035698 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In two clinical trial cohorts, a systematic biomarker discovery and validation approach identified miR-320e to be a novel prognostic biomarker that is associated with adverse clinical outcome in stage III CRC patients treated with 5-FU-based adjuvant chemotherapy. These findings have important implications for the personalised management of CRC patients. other hsa-mir-34a Colorectal Carcinoma 25362853 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. other hsa-mir-34a Colorectal Carcinoma 25712055 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. other hsa-mir-34a Colorectal Carcinoma 25924769 disease of cellular proliferation DOID:0080199 C19 D015179 114500 We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups. other hsa-mir-34a Colorectal Carcinoma 26183718 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. other hsa-mir-34c Colorectal Carcinoma 26674205 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Res suppressed CRC by specifically activating miR-34c-KITLG in vitro and in vivo; and the effect was strengthened in the presence of p53. Besides, Resexerted a synergistic effect with Oxa in a miR-34c dependent manner. We also suggested that Res-increased miR-34c could interfere IL-6-triggered CRC progression. other hsa-mir-362 Colorectal Carcinoma 27082577 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. other hsa-mir-374b Colorectal Carcinoma 26045793 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. other hsa-mir-375 Colorectal Carcinoma 22535378 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. other hsa-mir-375 Colorectal Carcinoma 28186962 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. other hsa-mir-375 Colorectal Carcinoma 29068474 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. other hsa-mir-378 Colorectal Carcinoma 25328987 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer. other hsa-mir-378 Colorectal Carcinoma 26496897 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression. other hsa-mir-378a Colorectal Carcinoma 24412052 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. other hsa-mir-423 Colorectal Carcinoma 26402653 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In conclusion, our findings demonstrated a critical impact of miR-423-3p on CRC growth. other hsa-mir-424 Colorectal Carcinoma 22535378 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. other hsa-mir-424 Colorectal Carcinoma 28054337 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. other hsa-mir-425 Colorectal Carcinoma 27082577 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. other hsa-mir-429 Colorectal Carcinoma 24237355 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-429 identified by dynamic transcriptome analysis is a new candidate biomarker for colorectal cancer prognosis. other hsa-mir-429 Colorectal Carcinoma 24510588 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy. other hsa-mir-429 Colorectal Carcinoma 28098901 disease of cellular proliferation DOID:0080199 C19 D015179 114500 after treatment with berberine and evodiamine for 24 h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted other hsa-mir-449b Colorectal Carcinoma 23674142 disease of cellular proliferation DOID:0080199 C19 D015179 114500 These data suggest that miR-449b plays a tumor-suppressive role in colon cancer stem cells other hsa-mir-451 Colorectal Carcinoma 24841830 disease of cellular proliferation DOID:0080199 C19 D015179 114500 fecal miR-223 and miR-451 hold promise in detecting CRC. other hsa-mir-455 Colorectal Carcinoma 27571956 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. other hsa-mir-4775 Colorectal Carcinoma 28095858 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition. other hsa-mir-486 Colorectal Carcinoma 26183718 disease of cellular proliferation DOID:0080199 C19 D015179 114500 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. other hsa-mir-497 Colorectal Carcinoma 24375248 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis. other hsa-mir-497 Colorectal Carcinoma 25926384 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition. other hsa-mir-497 Colorectal Carcinoma 25929865 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miRNA-497 Enhances the Sensitivity of Colorectal Cancer Cells to Neoadjuvant Chemotherapeutic Drug. other hsa-mir-502 Colorectal Carcinoma 26086375 disease of cellular proliferation DOID:0080199 C19 D015179 114500 While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets. other hsa-mir-503 Colorectal Carcinoma 28054337 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. other hsa-mir-518a Colorectal Carcinoma 25812680 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of miR-518a-3p activates the NIK-dependent NF-κB pathway in colorectal cancer. other hsa-mir-584 Colorectal Carcinoma 26494299 disease of cellular proliferation DOID:0080199 C19 D015179 114500 microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. other hsa-mir-592 Colorectal Carcinoma 25661360 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Up-regulation of miR-592 correlates with tumor progression and poor prognosis in patients with colorectal cancer. other hsa-mir-625 Colorectal Carcinoma 23861214 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Our results suggest that miR-625 may serve as an efficient clinical biomarker and a therapeutic tool for the inhibition of metastasis in CRC. other hsa-mir-630 Colorectal Carcinoma 24981248 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-630 is a prognostic marker for patients with colorectal cancer. other hsa-mir-650 Colorectal Carcinoma 26086375 disease of cellular proliferation DOID:0080199 C19 D015179 114500 While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets. other hsa-mir-7 Colorectal Carcinoma 26086375 disease of cellular proliferation DOID:0080199 C19 D015179 114500 While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets. other hsa-mir-7 Colorectal Carcinoma 27919977 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer. other hsa-mir-7 Colorectal Carcinoma 28929494 disease of cellular proliferation DOID:0080199 C19 D015179 114500 CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis. other hsa-mir-760 Colorectal Carcinoma 26086375 disease of cellular proliferation DOID:0080199 C19 D015179 114500 While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets. other hsa-mir-877 Colorectal Carcinoma 27082577 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. other hsa-mir-9 Colorectal Carcinoma 25940709 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis. other hsa-mir-92a Colorectal Carcinoma 25515201 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-92a is involved in lymph node metastasis of CRC patients through PTEN-regulated PI3K/AKT signaling pathway. other hsa-mir-92a Colorectal Carcinoma 22535378 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. other hsa-mir-92b Colorectal Carcinoma 28693229 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNAs as outcome predictors in patients with metastatic colorectal cancer treated with bevacizumab in combination with FOLFOX. other hsa-mir-93 Colorectal Carcinoma 25371073 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-93 suppress colorectal cancer development via Wnt/β-catenin pathway downregulating. other hsa-mir-93 Colorectal Carcinoma 26086375 disease of cellular proliferation DOID:0080199 C19 D015179 114500 While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets. other hsa-mir-95 Colorectal Carcinoma 25671802 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Glargine Promotes Human Colorectal Cancer Cell Proliferation via Upregulation of miR-95. other hsa-mir-95 Colorectal Carcinoma 27393650 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In conclusion, calycosin exerts an inhibitory effect on proliferation of CRC cells in vivo and in vitro, through ER尾-mediated regulation of the IGF-1R, PI3K/Akt signaling pathways and of miR-95 expression. other hsa-mir-96 Colorectal Carcinoma 25256312 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients. other hsa-mir-99a Colorectal Carcinoma 25197016 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MiR-107 and miR-99a-3p were validated as predictors of response to standard fluoropyrimidine-based chemotherapy in patients with mCRC. other hsa-let-7b Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-1 Colorectal Carcinoma 25196260 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway. other hsa-mir-106a Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-10b Colorectal Carcinoma 22322955 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells. other hsa-mir-1-1 Colorectal Carcinoma 22343615 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation. other hsa-mir-124-1 Colorectal Carcinoma 22885837 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. other hsa-mir-124-2 Colorectal Carcinoma 22885837 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. other hsa-mir-1246 Colorectal Carcinoma 22479426 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors. other hsa-mir-125b-1 Colorectal Carcinoma 21399871 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients. other hsa-mir-125b-2 Colorectal Carcinoma 21399871 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients. other hsa-mir-126 Colorectal Carcinoma 22848274 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer. other hsa-mir-1275 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-1280 Colorectal Carcinoma 22479426 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors. other hsa-mir-129-1 Colorectal Carcinoma 23744359 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. other hsa-mir-129-2 Colorectal Carcinoma 23744359 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. other hsa-mir-133a Colorectal Carcinoma 23968734 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-133a may play a key role in CRC genesis and metastasis, which suggests its potential role in the molecular therapy of cancer. other hsa-mir-135b Colorectal Carcinoma 26178670 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. other hsa-mir-137 Colorectal Carcinoma 23275153 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer other hsa-mir-140 Colorectal Carcinoma 22479426 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors. other hsa-mir-141 Colorectal Carcinoma 19830559 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-141:miR-141 regulates SIP1 to inhibit migration and invasion of CRC cells other hsa-mir-142 Colorectal Carcinoma 23397547 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors other hsa-mir-143 Colorectal Carcinoma 23866094 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-143 blocks the TLR2 signalling pathway in human CRC cells. This knowledge may pave the way for new clinical applications utilising miR-143 mimics in the treatment of patients with CRC. other hsa-mir-143 Colorectal Carcinoma 20094072 disease of cellular proliferation DOID:0080199 C19 D015179 114500 anti-oncomirs other hsa-mir-143 Colorectal Carcinoma 20620599 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-143:MiR-21 and miR-143 expressions were quantified by using the quantitative reverse transcription polymerase chain reaction method other hsa-mir-143 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-143 Colorectal Carcinoma 23128394 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression other hsa-mir-143 Colorectal Carcinoma 23574723 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers other hsa-mir-144 Colorectal Carcinoma 21929751 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. other hsa-mir-145 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-145 Colorectal Carcinoma 23128394 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression other hsa-mir-145 Colorectal Carcinoma 23397547 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors other hsa-mir-146b Colorectal Carcinoma 20881268 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-146b-3p and miR-486-5p are more abundant in KRAS mutated samples after cetuximab treatment respect to wild-type ones other hsa-mir-146b Colorectal Carcinoma 26178670 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. other hsa-mir-148a Colorectal Carcinoma 23056401 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer other hsa-mir-150 Colorectal Carcinoma 22052060 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Only one miR-150 was found to show a decrease in expression levels in the three tissue groups (normal, adenoma and cancer tissue) in parallel with increasing carcinogenesis of the colorectal tissue. In both ISH and qRT-PCR analysis, tumour tissue had reduced levels of miR-150 expression compared with paired non-cancerous tissue, which indicated that the levels of miR-150 expression were associated with CRC. Moreover, patients whose tumours had low miR-150 expression had shorter survival and a worse response to adjuvant chemotherapy than patients whose tumours had high miRNA expression. other hsa-mir-155 Colorectal Carcinoma 21806946 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Neurotensin Signaling Activates MicroRNAs -21 and -155 and Akt, Promotes Tumor Growth in Mice, and is Increased in Human Colon Tumors. other hsa-mir-155 Colorectal Carcinoma 20351277 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Modulation of mismatch repair and genomic stability by miR-155 other hsa-mir-16-1 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-16-2 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-181b-1 Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-181b-2 Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-18a Colorectal Carcinoma 25233396 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Stool-based miR-221 can be used as a non-invasive biomarker for the detection of CRC. other hsa-mir-18a Colorectal Carcinoma 23437304 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer other hsa-mir-193a Colorectal Carcinoma 23758639 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. other hsa-mir-194-1 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-194-2 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-195 Colorectal Carcinoma 20727858 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-195:microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells other hsa-mir-195 Colorectal Carcinoma 22479426 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors. other hsa-mir-19b-1 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-19b-1 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-19b-2 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-19b-2 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-200a Colorectal Carcinoma 25422078 disease of cellular proliferation DOID:0080199 C19 D015179 114500 PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-β1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function. other hsa-mir-200a Colorectal Carcinoma 23441132 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression other hsa-mir-200b Colorectal Carcinoma 25422078 disease of cellular proliferation DOID:0080199 C19 D015179 114500 PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-β1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function. other hsa-mir-200b Colorectal Carcinoma 22804917 disease of cellular proliferation DOID:0080199 C19 D015179 114500 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good progression-free survival . other hsa-mir-200b Colorectal Carcinoma 23441132 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression other hsa-mir-200c Colorectal Carcinoma 25422078 disease of cellular proliferation DOID:0080199 C19 D015179 114500 PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-β1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function. other hsa-mir-200c Colorectal Carcinoma 21873159 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. other hsa-mir-200c Colorectal Carcinoma 22735571 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. other hsa-mir-200c Colorectal Carcinoma 23441132 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression other hsa-mir-203 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-203 Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-20a Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-21 Colorectal Carcinoma 20620599 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-21:Our results support the hypothesis about oncogenic function of miR-21 other hsa-mir-21 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-21 Colorectal Carcinoma 21806946 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Neurotensin Signaling Activates MicroRNAs -21 and -155 and Akt, Promotes Tumor Growth in Mice, and is Increased in Human Colon Tumors. other hsa-mir-21 Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-21 Colorectal Carcinoma 22553926 disease of cellular proliferation DOID:0080199 C19 D015179 114500 EGF/Ras efficiently induces the miR-21 primary transcript, but this does not rapidly and simply translate into higher mature miR-21 levels. other hsa-mir-215 Colorectal Carcinoma 23532818 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery other hsa-mir-22 Colorectal Carcinoma 21629773 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-22 regulates hypoxia signaling in colon cancer cells. other hsa-mir-221 Colorectal Carcinoma 25233396 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Stool-based miR-221 can be used as a non-invasive biomarker for the detection of CRC. other hsa-mir-221 Colorectal Carcinoma 21873159 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. other hsa-mir-222 Colorectal Carcinoma 21873159 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. other hsa-mir-23a Colorectal Carcinoma 22628407 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-23a promotes the transition from indolent to invasive colorectal cancer. other hsa-mir-23a Colorectal Carcinoma 22684455 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-23a, a critical regulator of migRation and metastasis in colorectal cancer. other hsa-mir-23a Colorectal Carcinoma 23758639 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. other hsa-mir-26b Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-27a Colorectal Carcinoma 23530649 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a other hsa-mir-27a Colorectal Carcinoma 26178670 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. other hsa-mir-27b Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-32 Colorectal Carcinoma 26054686 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. other hsa-mir-324 Colorectal Carcinoma 22202009 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks. other hsa-mir-338 Colorectal Carcinoma 24277750 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-338-3p could inhibit colorectal carcinoma cell invasion and migration by inhibiting smoothened expression. other hsa-mir-338 Colorectal Carcinoma 23758639 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. other hsa-mir-372 Colorectal Carcinoma 22456107 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA-372 Is Associated with Poor Prognosis in Colorectal Cancer. other hsa-mir-451a Colorectal Carcinoma 21948564 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Microrna-451 is Involved in the Self-Renewal, Tumorigenicity and Chemoresistance of Colorectal Cancer Stem Cells. other hsa-mir-486 Colorectal Carcinoma 20881268 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-146b-3p and miR-486-5p are more abundant in KRAS mutated samples after cetuximab treatment respect to wild-type ones other hsa-mir-552 Colorectal Carcinoma 24778034 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases. other hsa-mir-592 Colorectal Carcinoma 24778034 disease of cellular proliferation DOID:0080199 C19 D015179 114500 MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases. other hsa-mir-638 Colorectal Carcinoma 21722265 disease of cellular proliferation DOID:0080199 C19 D015179 114500 The miRNA has a role in colorectal liver metastases. other hsa-mir-9 Colorectal Carcinoma 26178670 disease of cellular proliferation DOID:0080199 C19 D015179 114500 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. other hsa-mir-93 Colorectal Carcinoma 21406606 disease of cellular proliferation DOID:0080199 C19 D015179 114500 Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways. other hsa-mir-211 Cone Dystrophy 29209045 nervous system disease DOID:0050795 602093 HP:0000548 MiR-211 is essential for adult cone photoreceptor maintenance and visual function. other hsa-mir-183 Congenital Deafness 21621863 C565195 124480 The quantitative real-time polymerase chain reaction result demonstrated that the miR-183 family exhibits cell-specific expression in cochlear progenitor cells compared with neural stem cells. other hsa-mir-96 Congenital Deafness 26490746 C565195 124480 Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders and eventually congenital deafness as previously reported. other hsa-mir-27b Congenital Heart Diseases 25847058 cardiovascular system disease DOID:1682 Q24 D006330 617912 HP:0030680 The current study revealed for the first time that microRNAs may be important regulators in pulmonary arterial hypertension secondary to congenital heart disease, and demonstrated the correlation between microRNA-27b and pulmonary arterial hypertension with the implication of NOTCH1. other hsa-mir-302f Congenital Heart Diseases 27637763 cardiovascular system disease DOID:1682 Q24 D006330 617912 HP:0030680 Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways. other hsa-mir-184 Cornea Squamous Cell Carcinoma 29325388 nervous system disease DOID:13538 miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract other hsa-mir-106b Coronary Artery Disease 25415674 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a relationship between the miR-17-92 family and lipid metabolism, which merits further study. other hsa-mir-122 Coronary Artery Disease 26490079 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MicroRNA Biomarkers for Coronary Artery Disease other hsa-mir-125b Coronary Artery Disease 26446730 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 We found several synergistic effects between miR-125b and classical risk factors, such as age,sex, CR, FBG and HDL-C; the proportion of CHD attributable to the interaction of miR-125b and age was as high as 80%. Therefore, miR-125b was shown to play an important role in individual's susceptibility to developing CHD. other hsa-mir-126 Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-126 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-130a Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-130a Coronary Artery Disease 28947970 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. other hsa-mir-133a Coronary Artery Disease 28511772 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Transcoronary Concentration Gradient of microRNA-133a and Outcome in Patients With Coronary Artery Disease. other hsa-mir-134 Coronary Artery Disease 20230787 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes other hsa-mir-146a Coronary Artery Disease 26114385 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke. other hsa-mir-155 Coronary Artery Disease 24525789 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 miR-155 expression is associated inversely with complicated proatherogenic metabolic risk factors, and the severity of coronary stenotic lesions calculated by Gensini scores. other hsa-mir-155 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-16 Coronary Artery Disease 29306454 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD other hsa-mir-17 Coronary Artery Disease 25415674 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a relationship between the miR-17-93 family and lipid metabolism, which merits further study. other hsa-mir-17 Coronary Artery Disease 26134369 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-17-5p as circulating biomarkers for the severity of coronary atherosclerosis in coronary artery disease. other hsa-mir-17 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-18a Coronary Artery Disease 25415674 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a relationship between the miR-17-94 family and lipid metabolism, which merits further study. other hsa-mir-198 Coronary Artery Disease 20230787 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes other hsa-mir-19b Coronary Artery Disease 26459935 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Therefore our results indicate that miR-19b plays a key role in the attenuation of TNF-α-induced endothelial cell apoptosis and that this function is closely linked to the Apaf1/caspase-dependent pathway. other hsa-mir-206 Coronary Artery Disease 27994218 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-206 Suppresses the Progression of Coronary Artery Disease by Modulating Vascular Endothelial Growth Factor (VEGF) Expression. other hsa-mir-21 Coronary Artery Disease 20489163 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 miR-21:We identified a novel miR-21-dependent mechanism of ADMA-mediated APC dysfunction other hsa-mir-21 Coronary Artery Disease 25656948 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort. other hsa-mir-21 Coronary Artery Disease 26310808 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Local anti-miR delivery: the latest in the arsenal of drug-eluting stents other hsa-mir-214 Coronary Artery Disease 25575606 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 increased miR-214 level may be used to predict the presence and severity of coronary lesions in CAD patients. other hsa-mir-221 Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-221 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-222 Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-222 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-223 Coronary Artery Disease 29306454 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD other hsa-mir-23a Coronary Artery Disease 25656948 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study other hsa-mir-31 Coronary Artery Disease 21946298 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-340 Coronary Artery Disease 22022480 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*. other hsa-mir-34a Coronary Artery Disease 25656948 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort. other hsa-mir-370 Coronary Artery Disease 20230787 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes other hsa-mir-486 Coronary Artery Disease 26485305 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients. other hsa-mir-616 Coronary Artery Disease 27615006 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Relationship of microRNA 616 gene polymorphism with prognosis of patients with premature coronary artery disease. other hsa-mir-624 Coronary Artery Disease 22022480 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*. other hsa-mir-92a Coronary Artery Disease 25415674 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 a relationship between the miR-17-95 family and lipid metabolism, which merits further study. other hsa-mir-92a Coronary Artery Disease 26485305 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients. other hsa-mir-92a Coronary Artery Disease 29306454 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD other hsa-mir-92a-1 Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-92a-2 Coronary Artery Disease 21195052 cardiovascular system disease DOID:3393 I20-I25 D003324 608320 Coronary Artery Disease other hsa-mir-100 Coronary Atherosclerosis 25519160 I25.1 D003324 HP:0004929 miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. other hsa-mir-138 Costello Syndrome 26138095 genetic disease DOID:0050469 D056685 218040 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-206 Costello Syndrome 26138095 genetic disease DOID:0050469 D056685 218040 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-330 Costello Syndrome 26138095 genetic disease DOID:0050469 D056685 218040 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-342 Costello Syndrome 26138095 genetic disease DOID:0050469 D056685 218040 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-99b Costello Syndrome 26138095 genetic disease DOID:0050469 D056685 218040 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-126 Coxsackievirus Infection 23811937 B97.11 D006223 MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/β-catenin signal pathways. other hsa-mir-142 Crohn Disease 25886994 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC. other hsa-mir-149 Crohn Disease 28260036 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 Comprehensive bioinformatics analyses of Crohn's disease. other hsa-mir-155 Crohn Disease 29263823 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 a small subset had inflammatory responses almost comparable to wild-type patients on both gene and miR-155 regulatory levels other hsa-mir-200b Crohn Disease 22294131 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 miR-200b is involved in intestinal fibrosis of Crohn's disease. other hsa-mir-21 Crohn Disease 25886994 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC. other hsa-mir-29 Crohn Disease 24054330 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. other hsa-mir-29 Crohn Disease 24641356 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts. other hsa-mir-29b Crohn Disease 28190086 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. other hsa-mir-31 Crohn Disease 25886994 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC. other hsa-mir-4447 Crohn Disease 28260036 gastrointestinal system disease DOID:8778 K50 D003424 266600 HP:0100280 Comprehensive bioinformatics analyses of Crohn's disease. other hsa-let-7e Cystic Fibrosis 25800681 genetic disease DOID:1485 E84 D003550 219700 Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers. other hsa-mir-125a Cystic Fibrosis 25800681 genetic disease DOID:1485 E84 D003550 219700 Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers. other hsa-mir-146a Cystic Fibrosis 27689251 genetic disease DOID:1485 E84 D003550 219700 miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs. other hsa-mir-155 Cystic Fibrosis 21282106 genetic disease DOID:1485 E84 D003550 219700 Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyper-expression of interleukin-8. other hsa-mir-155 Cystic Fibrosis 27689251 genetic disease DOID:1485 E84 D003550 219700 miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs. other hsa-mir-181b Cystic Fibrosis 29044225 genetic disease DOID:1485 E84 D003550 219700 microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense. other hsa-mir-199a Cystic Fibrosis 25665524 genetic disease DOID:1485 E84 D003550 219700 Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. other hsa-mir-200 Cystic Fibrosis 26292219 genetic disease DOID:1485 E84 D003550 219700 Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA. other hsa-mir-21 Cystic Fibrosis 19997496 genetic disease DOID:1485 E84 D003550 219700 mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection other hsa-mir-23b Cystic Fibrosis 19997496 genetic disease DOID:1485 E84 D003550 219700 mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection other hsa-mir-27b Cystic Fibrosis 19997496 genetic disease DOID:1485 E84 D003550 219700 mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection other hsa-mir-30b Cystic Fibrosis 19997496 genetic disease DOID:1485 E84 D003550 219700 mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection other hsa-mir-370 Cystic Fibrosis 27689251 genetic disease DOID:1485 E84 D003550 219700 miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs. other hsa-mir-509 Cystic Fibrosis 24829907 genetic disease DOID:1485 E84 D003550 219700 Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression. other hsa-mir-708 Cystic Fibrosis 27689251 genetic disease DOID:1485 E84 D003550 219700 miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs. other hsa-mir-99b Cystic Fibrosis 25800681 genetic disease DOID:1485 E84 D003550 219700 Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers. other hsa-mir-34a Dementia 21956116 disease of mental health DOID:1307 F03 D003704 127750 HP:0000726 miR-34a was among the most highly induced miRNAs in HIV-1 Tat-treated neurons. other hsa-mir-126 Dengue Virus Infection 27039024 disease by infectious agent DOID:12205 A90 D003715 614371 GRP75 is involved in processing of host miRNA, hsa-mir-126, that down regulates dengue virus replication. other hsa-mir-30e Dengue Virus Infection 25122182 disease by infectious agent DOID:12205 A90 D003715 614371 MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. other hsa-mir-675 Dental Enamel Hypoplasia 28963438 gastrointestinal system disease DOID:693 D003744 HP:0006297 DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. other hsa-mir-185 Depression Disorder 24213247 disease of mental health DOID:1596 F32.9 D003866 The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. other hsa-mir-491 Depression Disorder 24213247 disease of mental health DOID:1596 F32.9 D003866 The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. other hsa-mir-206 Dermatomyositis 24288551 integumentary system disease DOID:10223 M33 D003882 Correlation between the frequency of Th17 cell and the expression of microRNA-206 in patients with dermatomyositis. other hsa-let-7a Diabetes Mellitus 25759134 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-103 Diabetes Mellitus 27137869 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Long-term treatment with 500鈥壩糓 CML during adipogenesis resulted in increases in miR-103 and miR-143 levels other hsa-mir-126 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-126 Diabetes Mellitus 23713864 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Recent studies identified circulating microRNA-126 as a biomarker for myocardial injury and vascular damage in diabetes. other hsa-mir-126 Diabetes Mellitus 29477147 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 While both miRs have differential functions on endothelial VCAM expression, miR-19a and miR-126 cooperate to exhibit anti-thrombotic properties via regulating vascular TF expression other hsa-mir-130b Diabetes Mellitus 28433632 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 inhibition of miR-130b-3p appears to improve mitochondrial biogenesis signaling and protect placental trophoblast cells from oxidative stress other hsa-mir-143 Diabetes Mellitus 27137869 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Long-term treatment with 500鈥壩糓 CML during adipogenesis resulted in increases in miR-103 and miR-143 levels other hsa-mir-145 Diabetes Mellitus 26636106 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes. other hsa-mir-146a Diabetes Mellitus 20086228 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice. other hsa-mir-155 Diabetes Mellitus 23250986 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Global Remodeling of the Vascular Stem Cell Niche in Bone Marrow of Diabetic Patients: Implication of the miR-155/FOXO3a Signaling Pathway other hsa-mir-155 Diabetes Mellitus 23560074 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts other hsa-mir-155 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-17 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-17 Diabetes Mellitus 25249581 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Ask1 deletion suppressed diabetes-induced IRE1伪 endoriboneclease activities, which led to X-box binding protein 1 mRNA cleavage, an ER stress marker, decreased expression of microRNAs, and increased expression of a miR-17 target other hsa-mir-17 Diabetes Mellitus 26660634 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 miR-17 repression mediates the pro-apoptotic effect of high glucose other hsa-mir-186 Diabetes Mellitus 25059983 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Differentiation of human induced pluripotent stem cells into insulin-like cell clusters with miR-186 and miR-375 by using chemical transfection. other hsa-mir-19a Diabetes Mellitus 29477147 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 While both miRs have differential functions on endothelial VCAM expression, miR-19a and miR-126 cooperate to exhibit anti-thrombotic properties via regulating vascular TF expression other hsa-mir-200c Diabetes Mellitus 25759134 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-204 Diabetes Mellitus 27438705 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers. other hsa-mir-21 Diabetes Mellitus 26826461 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Role of microRNA 21 in diabetes and associated/related diseases. other hsa-mir-21 Diabetes Mellitus 21613227 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 microRNA-21 orchestrates high glucose-induced signals to TORC1 for renal cell pathology in diabetes. other hsa-mir-21 Diabetes Mellitus 20086228 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice. other hsa-mir-221 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-222 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-223 Diabetes Mellitus 25944670 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Thus, calpain inhibition may be one means of normalizing platelet miRNA processing as well as platelet function in diabetes mellitus. other hsa-mir-26b Diabetes Mellitus 26636106 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes. other hsa-mir-29a Diabetes Mellitus 26636106 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes. other hsa-mir-29b-2 Diabetes Mellitus 25587719 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. other hsa-mir-301a Diabetes Mellitus 23573265 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators other hsa-mir-31 Diabetes Mellitus 26318001 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin. other hsa-mir-31 Diabetes Mellitus 21946298 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-320a Diabetes Mellitus 22900199 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 miR-320 Regulates Glucose-Induced Gene Expression in Diabetes. other hsa-mir-34a Diabetes Mellitus 20086228 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice. other hsa-mir-375 Diabetes Mellitus 16195701 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 mir-375 was found to modulate glucose-stimulated insulin secretion and exocytosis. other hsa-mir-375 Diabetes Mellitus 17965831 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 For instance, miR-375 was shown to directly regulate insulin secretion from pancreatic islet cells. Overexpression of miR-375 led to an enhanced inhibition of insulin exocytosis, whereas anti-sense to miR-375 enhanced insulin secretion by blocking the effects of the miRNA. other hsa-mir-375 Diabetes Mellitus 25059983 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Differentiation of human induced pluripotent stem cells into insulin-like cell clusters with miR-186 and miR-375 by using chemical transfection. other hsa-mir-375 Diabetes Mellitus 19800254 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Recent studies, for example, implicate miR-375 in pancreatic islet cell viability and function, and removal or overexpression of miR-375 profoundly affects glucose metabolism. other hsa-mir-375 Diabetes Mellitus 26311337 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 This review analyzes the role of miRNAs in obesity and insulin resistance, focusing on the miR-17/92, miR-143-145, miR-130, let-7, miR-221/222, miR-200, miR-223, miR-29 and miR-375 families, as well as miRNA changes by relevant tissue other hsa-mir-410 Diabetes Mellitus 26307561 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 miR-410 enhanced hESC-derived pancreatic endoderm transplant to alleviate gestational diabetes mellitus. other hsa-mir-494 Diabetes Mellitus 24349514 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. other hsa-mir-503 Diabetes Mellitus 29285014 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 microRNA-503 contribute to pancreatic beta cell dysfunction by targeting the mTOR pathway in gestational diabetes mellitus other hsa-mir-550a Diabetes Mellitus 27935135 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 Micro RNA-550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes. other hsa-mir-590 Diabetes Mellitus 26770982 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p)and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model. The procedure significantly improved glucose metabolism and other symptoms of T2D. other hsa-mir-92a Diabetes Mellitus 26283734 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation. other hsa-mir-92a Diabetes Mellitus 26636106 disease of metabolism DOID:9351 E10-E14 D003920 222100 HP:0000819 CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes. other hsa-let-7a Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-let-7g Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-126 Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-130b Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-137 Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-137 Diabetes Mellitus, Gestational 29505767 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 High glucose induces dysfunction of human umbilical vein endothelial cells by upregulating miR-137 in gestational diabetes mellitus. other hsa-mir-148a Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-27a Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-30c Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-30d Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-33a Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-362 Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-452 Diabetes Mellitus, Gestational 27562513 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. other hsa-mir-502 Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-508 Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-9 Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-92a Diabetes Mellitus, Gestational 26302821 disease of metabolism DOID:11714 O24.4 D016640 606176 HP:0009800 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. other hsa-mir-34a Diabetes Mellitus, Type 1 28185128 disease of metabolism DOID:9744 E10 D003922 222100 HP:0100651 Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. other hsa-let-7f Diabetes Mellitus, Type 2 23723366 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 let-7f, a microRNA which has been related to endothelial angiogenic function, is found to play key role in TSP-2 increase, but let-7f did not directly interact with TSP-2 mRNA. other hsa-mir-1 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-103 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b. other hsa-mir-103a-1 Diabetes Mellitus, Type 2 21654750 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 MicroRNAs 103 and 107 regulate insulin sensitivity. other hsa-mir-103a-2 Diabetes Mellitus, Type 2 21654750 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 MicroRNAs 103 and 107 regulate insulin sensitivity. other hsa-mir-107 Diabetes Mellitus, Type 2 22645244 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes. other hsa-mir-107 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b. other hsa-mir-122 Diabetes Mellitus, Type 2 27592052 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells. other hsa-mir-122 Diabetes Mellitus, Type 2 27899485 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. other hsa-mir-122 Diabetes Mellitus, Type 2 22488426 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122. other hsa-mir-124a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-126 Diabetes Mellitus, Type 2 25986735 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Circulating miR-126 is a potential biomarker to predict the onset of type 2 diabetes mellitus in susceptible individuals. other hsa-mir-126 Diabetes Mellitus, Type 2 27696070 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 MicroRNA-126 and micro-/macrovascular complications of type 1 diabetes in the EURODIAB Prospective Complications Study. other hsa-mir-126 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-128a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-133a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-133b Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-143 Diabetes Mellitus, Type 2 28270439 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women. other hsa-mir-143 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-144 Diabetes Mellitus, Type 2 27906902 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. other hsa-mir-145 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-146 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-146a Diabetes Mellitus, Type 2 21249428 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. other hsa-mir-155 Diabetes Mellitus, Type 2 27711113 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice. other hsa-mir-15a Diabetes Mellitus, Type 2 28289072 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. other hsa-mir-15a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-15b Diabetes Mellitus, Type 2 28289072 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. other hsa-mir-15b Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-181b Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-192 Diabetes Mellitus, Type 2 27906902 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. other hsa-mir-192 Diabetes Mellitus, Type 2 29040025 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Lower concentrations of miR-192 and miR-375 were also found, which correlated positively with HOMA-IR other hsa-mir-195 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-200 Diabetes Mellitus, Type 2 26032109 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Preventing β-cell apoptosis and T2DM with microRNAs--a role for miR-200 other hsa-mir-200a Diabetes Mellitus, Type 2 24812635 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 miR-448, let-7b, miR-540, miR-296, miR-880, miR-200a, miR-500, miR-10b, miR-336, miR-30d, miR-208, let-7e, miR-142-5p, miR-874, miR-375, miR-879, miR-501, and miR-188 were upregulated, while miR-301b, miR-134, and miR-652 were downregulated in TMH group. other hsa-mir-21 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-221 Diabetes Mellitus, Type 2 27420990 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05) other hsa-mir-222 Diabetes Mellitus, Type 2 27420990 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05) other hsa-mir-223 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-24 Diabetes Mellitus, Type 2 25737017 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Pioglitazone increases circulating microRNA-24 with decrease in coronary neointimal hyperplasia in type 2 diabetic patients- optical coherence tomography analysis. other hsa-mir-27b Diabetes Mellitus, Type 2 28698281 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes. other hsa-mir-27b Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b other hsa-mir-29 Diabetes Mellitus, Type 2 24349318 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Urinary miR-29a correlated with albuminuria while urinary miR-29b correlated with carotid intima-media thickness (cIMT) in patients with type 2 diabetes. Therefore, they may have the potential to serve as alternative biomarker for diabetic nephropathy and atherosclerosis in type 2 diabetes. other hsa-mir-29 Diabetes Mellitus, Type 2 28404597 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. other hsa-mir-29 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-29a Diabetes Mellitus, Type 2 27906902 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. other hsa-mir-29a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-30a Diabetes Mellitus, Type 2 27758866 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. other hsa-mir-320 Diabetes Mellitus, Type 2 24825548 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. other hsa-mir-320 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-33 Diabetes Mellitus, Type 2 22488426 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122. other hsa-mir-33a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-33b Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-34a Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-370 Diabetes Mellitus, Type 2 26948318 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 salidroside can directly decrease the expression of miR-370 in type 2 diabetic mice other hsa-mir-370 Diabetes Mellitus, Type 2 22488426 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122. other hsa-mir-375 Diabetes Mellitus, Type 2 24812635 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Through target gene analysis and real-time PCR verification, we found that these miRNAs, especially miR-375 and miR-30d, can stimulate insulin secretion in islet. other hsa-mir-375 Diabetes Mellitus, Type 2 29040025 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Lower concentrations of miR-192 and miR-375 were also found, which correlated positively with HOMA-IR other hsa-mir-376 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-383 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-384 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). other hsa-mir-423 Diabetes Mellitus, Type 2 28411267 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway. other hsa-mir-4687 Diabetes Mellitus, Type 2 27597954 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. other hsa-mir-652 Diabetes Mellitus, Type 2 28270439 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women. other hsa-mir-7 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-9 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-92a Diabetes Mellitus, Type 2 24379347 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The updated subnetwork predicted that miR-126/-193b/-92a control CCL2 production by several TFs, including v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), MYC-associated factor X (MAX), and specificity protein 12 (SP1). other hsa-mir-96 Diabetes Mellitus, Type 2 24944010 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (尾) cell development has been well discussed. other hsa-mir-99a Diabetes Mellitus, Type 2 23762265 disease of metabolism DOID:9352 E11 D003924 125853 HP:0005978 Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway. other hsa-mir-384 Diabetic Encephalopathy 29511445 nervous system disease DOID:0050850 Control of macrophage autophagy by miR-384-5p in the development of diabetic encephalopathy. other hsa-mir-124 Diabetic Nephropathy 24556741 E10-11.21 D003928 These results provide a novel idea that curcumin prevents against podocytic adhesive capacity damage under mechanical stress by inhibitting miR-124 other hsa-mir-192 Diabetic Nephropathy 22223877 E10-11.21 D003928 Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy other hsa-mir-21 Diabetic Nephropathy 24370587 E10-11.21 D003928 Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy. other hsa-mir-23b Diabetic Nephropathy 26898629 E10-11.21 D003928 Diabetic nephropathy: MiR-23b protects against fibrosis in diabetic nephropathy. other hsa-mir-27a Diabetic Nephropathy 28277542 E10-11.21 D003928 MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy. other hsa-mir-30c Diabetic Nephropathy 28127848 E10-11.21 D003928 MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. other hsa-mir-34a Diabetic Nephropathy 27858840 E10-11.21 D003928 Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway. other hsa-let-7i Diabetic Polyneuropathy 29533535 nervous system disease DOID:12785 D003929 let-7i is widely expressed in sensory neurons, supports their growth and is depleted in experimental DPN other hsa-mir-126 Diabetic Retinopathy 27225425 nervous system disease DOID:8947 E10-11.31 D003930 MicroRNA-126 (miR-126) plays a potential role in the pathogenesis in DR other hsa-mir-1273g Diabetic Retinopathy 29197896 nervous system disease DOID:8947 E10-11.31 D003930 miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway. other hsa-mir-146b Diabetic Retinopathy 28170537 nervous system disease DOID:8947 E10-11.31 D003930 Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p. other hsa-mir-200b Diabetic Retinopathy 21357793 nervous system disease DOID:8947 E10-11.31 D003930 MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy. other hsa-mir-21 Diabetic Retinopathy 28270521 nervous system disease DOID:8947 E10-11.31 D003930 Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα. other hsa-mir-34a Diabetic Retinopathy 27977785 nervous system disease DOID:8947 E10-11.31 D003930 LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. other hsa-mir-15a Diabetic Vasculopathy 24397367 cardiovascular system disease DOID:11713 D003925 Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment. other hsa-mir-181c Diabetic Vasculopathy 24397367 cardiovascular system disease DOID:11713 D003925 Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment. other hsa-mir-20b Diabetic Vasculopathy 24397367 cardiovascular system disease DOID:11713 D003925 Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment. other hsa-let-7 Diffuse Lipomatosis 22642449 integumentary system disease DOID:3923 First description of inhibition of let-7 microRNA expression and HMGA2 overexpression in a case of deep-seated diffuse lipomatosis. other hsa-let-7a Digeorge Syndrome 26202964 genetic disease DOID:11198 D82.1 D004062 188400 Collectively, our data suggest a novel mechanism that SUMOylation of DGCR8 controls direct functions of pri-miRNAs in gene silencing. other hsa-mir-223 Disease of Metabolism 26512640 disease of metabolism DOID:0014667 E88.9 D008659 the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders. other hsa-mir-1-1 Distal Myopathy 20619221 G72.9 D049310 160500 miR-1:have a profound influence on multiple myopathies other hsa-mir-1-2 Distal Myopathy 20619221 G72.9 D049310 160500 miR-1:have a profound influence on multiple myopathies other hsa-mir-133a-1 Distal Myopathy 20619221 G72.9 D049310 160500 miR-133:have a profound influence on multiple myopathies other hsa-mir-133a-2 Distal Myopathy 20619221 G72.9 D049310 160500 miR-133:have a profound influence on multiple myopathies other hsa-mir-206 Distal Myopathy 20619221 G72.9 D049310 160500 miR-206:have a profound influence on multiple myopathies other hsa-mir-1246 Down Syndrome 21637297 genetic disease DOID:14250 Q90 D004314 190685 p53 downregulates Down syndrome-associated DYRK1A through miR-1246. other hsa-mir-155 Down Syndrome 17468766 genetic disease DOID:14250 Q90 D004314 190685 Because miR-155 maps to chromosome 21, Setupathy et al. speculate that miR-155 overexpression in trisomics'a which they confirmed experimentally a accounts for the lower levels of diastolic and systolic blood pressure associated with Down syndrome. other hsa-mir-155 Down Syndrome 24938108 genetic disease DOID:14250 Q90 D004314 190685 Analysis of mtDNA, miR-155 and BACH1 expression in hearts from donors with and without Down syndrome. other hsa-mir-155 Down Syndrome 26546125 genetic disease DOID:14250 Q90 D004314 190685 The lentiviral miRNA-sponge strategy demonstrated the genome-wide regulatory effects of miR-155 and miR-802. Furthermore, the analysis combining predicted candidates and experimental transcriptomic data proved to retrieve genes with potential significance in DS-hippocampal phenotype bridging with DS other neurological-associated diseases such as Alzheimer's disease. other hsa-mir-802 Down Syndrome 26546125 genetic disease DOID:14250 Q90 D004314 190685 The lentiviral miRNA-sponge strategy demonstrated the genome-wide regulatory effects of miR-155 and miR-802. Furthermore, the analysis combining predicted candidates and experimental transcriptomic data proved to retrieve genes with potential significance in DS-hippocampal phenotype bridging with DS other neurological-associated diseases such as Alzheimer's disease. other hsa-mir-424 Early-Stage Colon Adenocarcinoma 28714374 C18.9 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. other hsa-mir-548am Early-Stage Colon Adenocarcinoma 28714374 C18.9 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. other hsa-mir-548c Early-Stage Colon Adenocarcinoma 28714374 C18.9 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. other hsa-mir-548i Early-Stage Colon Adenocarcinoma 28714374 C18.9 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. other hsa-mir-31 Early-Stage Colon Carcinoma 26173758 C18.9 The potential role of microRNA-31 expression in early colorectal cancer. other hsa-mir-150 Early-Stage Small-Cell Lung Carcinoma 24637927 C34.90 D055752 211980 A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy. other hsa-mir-886 Early-Stage Small-Cell Lung Carcinoma 24637927 C34.90 D055752 211980 A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy. other hsa-mir-1246 Ebola Hemorrhagic Fever 25218824 disease by infectious agent DOID:4325 A98.4 D019142 Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. other hsa-mir-22 Emphysema 26482970 J43 D004646 130700 HP:0002097 MicroRNA miR-22 drives T(H)17 responses in emphysema. other hsa-mir-155 Encephalitis 24516198 disease by infectious agent DOID:9588 G04.90 D004660 HP:0002383 Critical role of microRNA-155 in herpes simplex encephalitis. miR-H2 other hsa-mir-132 Encephalomyelitis 23780851 nervous system disease DOID:640 B01.11 D004679 MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration. other hsa-mir-155 Encephalomyelitis 24332164 nervous system disease DOID:640 B01.11 D004679 MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis. other hsa-mir-155 Encephalomyelitis 21788439 nervous system disease DOID:640 B01.11 D004679 Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis. other hsa-mir-155 Endometrial Neoplasms 21176560 reproductive system disease DOID:1380 C54.1 D016889 608089 Hsa-miR-155 may play an important role in the proliferation, and metastasis of endometrial cancer, which may be a indicator in the diagnosis and prognosis of endometrial cancer and may be used as a predictive biomarker. other hsa-mir-181 Endometrial Neoplasms 22911744 reproductive system disease DOID:1380 C54.1 D016889 608089 Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process. other hsa-mir-182 Endometrial Neoplasms 22766795 reproductive system disease DOID:1380 C54.1 D016889 608089 In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity. other hsa-mir-183 Endometrial Neoplasms 22766795 reproductive system disease DOID:1380 C54.1 D016889 608089 In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity. other hsa-mir-183 Endometrial Neoplasms 22911744 reproductive system disease DOID:1380 C54.1 D016889 608089 Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process. other hsa-mir-200 Endometrial Neoplasms 22911744 reproductive system disease DOID:1380 C54.1 D016889 608089 Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process. other hsa-mir-200a Endometrial Neoplasms 22766795 reproductive system disease DOID:1380 C54.1 D016889 608089 In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity. other hsa-mir-200a Endometrial Neoplasms 23295740 reproductive system disease DOID:1380 C54.1 D016889 608089 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines other hsa-mir-200a Endometrial Neoplasms 23743934 reproductive system disease DOID:1380 C54.1 D016889 608089 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. other hsa-mir-200b Endometrial Neoplasms 23295740 reproductive system disease DOID:1380 C54.1 D016889 608089 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines other hsa-mir-200b Endometrial Neoplasms 23743934 reproductive system disease DOID:1380 C54.1 D016889 608089 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. other hsa-mir-200c Endometrial Neoplasms 22766795 reproductive system disease DOID:1380 C54.1 D016889 608089 In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity. other hsa-mir-200c Endometrial Neoplasms 23295740 reproductive system disease DOID:1380 C54.1 D016889 608089 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines other hsa-mir-200c Endometrial Neoplasms 23743934 reproductive system disease DOID:1380 C54.1 D016889 608089 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. other hsa-mir-204 Endometrial Neoplasms 27438705 reproductive system disease DOID:1380 C54.1 D016889 608089 It is believed that miR-204 acts as a tumor-suppressor via promoting apoptosis, conferring the resistance of cancer cells to chemotherapy, and suppressing the self-renewal of cancer stem cells (CSCs) and the epithelial to mesenchymal transition (EMT). other hsa-mir-205 Endometrial Neoplasms 27655663 reproductive system disease DOID:1380 C54.1 D016889 608089 Locked nucleic acid-inhibitor of miR-205 decreases endometrial cancer cells proliferation in vitro and in vivo. other hsa-mir-30c-1 Endometrial Neoplasms 22139444 reproductive system disease DOID:1380 C54.1 D016889 608089 Endometrial Neoplasms other hsa-mir-30c-2 Endometrial Neoplasms 22139444 reproductive system disease DOID:1380 C54.1 D016889 608089 Endometrial Neoplasms other hsa-mir-142 Endometrial Stromal Sarcoma 25754227 reproductive system disease DOID:4226 Z85.42 D018203 miR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells. other hsa-mir-143 Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-145 Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-17 Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-183 Endometriosis 24173391 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis. other hsa-mir-199a Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-200 Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-20a Endometriosis 22648654 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. other hsa-mir-20a Endometriosis 29463003 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis other hsa-mir-210 Endometriosis 25516558 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 This work was supported in part by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (no. 13237327 to K.N., no. 25861500 to Y.K. and no. 23592407 to H.N.). There are no conflicts of interest to declare. other hsa-mir-27b Endometriosis 29247225 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 Rg3 effectively altered fibrotic properties of HESCs from patients with endometriosis, which is likely associated with miR-27b-3p modulation other hsa-mir-29c Endometriosis 27778641 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4. other hsa-mir-33b Endometriosis 28537685 reproductive system disease DOID:289 N80.0 D004715 131200 HP:0030127 MiR-33b can mediate cell apoptosis, alter VEGF and MMP-9 expression and affect proliferation and apoptosis of uterus endometrial cells, thus participating endometriosis formation other hsa-mir-101-1 Endomyocardial Fibrosis 22811578 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor Pathway. other hsa-mir-101-2 Endomyocardial Fibrosis 22811578 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-ж┿ Pathway. other hsa-mir-18a Endomyocardial Fibrosis 28733035 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. other hsa-mir-208a Endomyocardial Fibrosis 17786230 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 Clearly, miR-208 is also essential for expression of the genes involved in cardiac fibrosis and hypertrophic growth. other hsa-mir-21 Endomyocardial Fibrosis 25903305 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. other hsa-mir-25 Endomyocardial Fibrosis 19919989 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 both miR-25 and miR-29a were sufficient to decrease collagen gene expression other hsa-mir-29a Endomyocardial Fibrosis 19919989 cardiovascular system disease DOID:12932 I42.3 D004719 HP:0006685 both miR-25 and miR-29a were sufficient to decrease collagen gene expression other hsa-mir-146a Enterovirus Infection 24561744 B97.10 D004769 Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. other hsa-mir-146a Enterovirus Infection 25469565 B97.10 D004769 EV71-induced cell apoptosis is partly governed by altered miRNAs. other hsa-mir-370 Enterovirus Infection 25469565 B97.10 D004769 EV71-induced cell apoptosis is partly governed by altered miRNAs. other hsa-let-7d Ependymoma 22053178 disease of cellular proliferation DOID:5074 C71.0 D004806 HP:0002888 Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival. other hsa-mir-203 Ependymoma 22053178 disease of cellular proliferation DOID:5074 C71.0 D004806 HP:0002888 miR-203 is an independent marker for relapse compared to the parameters that are currently used. other hsa-mir-367 Ependymoma 22053178 disease of cellular proliferation DOID:5074 C71.0 D004806 HP:0002888 Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival. other hsa-mir-596 Ependymoma 22053178 disease of cellular proliferation DOID:5074 C71.0 D004806 HP:0002888 Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival. other hsa-let-7d Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-106b Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-130a Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-132 Epilepsy 24553459 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis. other hsa-mir-132 Epilepsy 23485811 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 Functional studies employing antagomirs have identified contributions from miR-34a and miR-132 to seizure-induced neuronal death whereas silencing miR-134 potently reduced status epilepticus, seizure-damage and the later occurrence of spontaneous seizures. other hsa-mir-132 Epilepsy 24282394 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 Targeting miR-34a, miR-132 and miR-184 has been reported to alter seizure-induced neuronal death, whereas targeting miR-134 was neuroprotective, reduced seizure severity during status epilepticus and reduced the later emergence of recurrent spontaneous seizures. other hsa-mir-146a Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-146a Epilepsy 24553459 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis. other hsa-mir-155 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-15a Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-184 Epilepsy 24282394 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 Targeting miR-34a, miR-132 and miR-184 has been reported to alter seizure-induced neuronal death, whereas targeting miR-134 was neuroprotective, reduced seizure severity during status epilepticus and reduced the later emergence of recurrent spontaneous seizures. other hsa-mir-194 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-21 Epilepsy 27725160 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. other hsa-mir-221 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-222 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-223 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-23a Epilepsy 24553459 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis. other hsa-mir-301a Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-30b Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-342 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-mir-34a Epilepsy 24553459 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis. other hsa-mir-34a Epilepsy 23485811 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 Functional studies employing antagomirs have identified contributions from miR-34a and miR-132 to seizure-induced neuronal death whereas silencing miR-134 potently reduced status epilepticus, seizure-damage and the later occurrence of spontaneous seizures. other hsa-mir-4446 Epilepsy 26506013 nervous system disease DOID:1826 G40 D004827 PS601068 HP:0001250 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. other hsa-let-7 Epstein-Barr Virus Infection 25031339 B27.90 D020031 300853 Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer. other hsa-mir-10b Esophageal Neoplasms 20075075 C15.9 D004938 133239 HP:0100751 MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. other hsa-mir-1286 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-143 Esophageal Neoplasms 23276710 C15.9 D004938 133239 HP:0100751 miR-143 may act as a tumor suppressor in ESCC other hsa-mir-148a Esophageal Neoplasms 21246413 C15.9 D004938 133239 HP:0100751 Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells. other hsa-mir-193a Esophageal Neoplasms 21420070 C15.9 D004938 133239 HP:0100751 The expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was associated with the presence of lymph node metastasis. other hsa-mir-199a-1 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-199a-2 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-200a Esophageal Neoplasms 28635228 C15.9 D004938 133239 HP:0100751 MALAT1 functions as a competing endogenous RNA to regulate the expressions of ZEB1 and ZEB2 by sponging miR-200a and promotes invasion and migration of esophageal cancer cells through inducing epithelial-mesenchymal transition other hsa-mir-200c Esophageal Neoplasms 21248297 C15.9 D004938 133239 HP:0100751 Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. other hsa-mir-21 Esophageal Neoplasms 22689922 C15.9 D004938 133239 HP:0100751 Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. other hsa-mir-22 Esophageal Neoplasms 23188185 C15.9 D004938 133239 HP:0100751 Increased miRNA-22 expression sensitizes esophageal squamous cell carcinoma to irradiation other hsa-mir-25 Esophageal Neoplasms 22450326 C15.9 D004938 133239 HP:0100751 MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma. other hsa-mir-296 Esophageal Neoplasms 22939244 C15.9 D004938 133239 HP:0100751 differentially regulated other hsa-mir-302a Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-302f Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-31 Esophageal Neoplasms 22689922 C15.9 D004938 133239 HP:0100751 Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. other hsa-mir-31 Esophageal Neoplasms 22706599 C15.9 D004938 133239 HP:0100751 MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. other hsa-mir-342 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-425 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-451 Esophageal Neoplasms 27896643 C15.9 D004938 133239 HP:0100751 A novel signaling role for miR-451 in esophageal tumor microenvironment and its contribution to tumor progression. other hsa-mir-451a Esophageal Neoplasms 23053883 C15.9 D004938 133239 HP:0100751 Effect of miR-451 on the Biological Behavior of the Esophageal Carcinoma Cell Line EC9706 other hsa-mir-455 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-486 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-519c Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-548d-1 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-548d-2 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-617 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-758 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-766 Esophageal Neoplasms 21743970 C15.9 D004938 133239 HP:0100751 Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy. other hsa-mir-92a-1 Esophageal Neoplasms 21148309 C15.9 D004938 133239 HP:0100751 microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. other hsa-mir-92a-2 Esophageal Neoplasms 21148309 C15.9 D004938 133239 HP:0100751 microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. other hsa-mir-99b Esophageal Neoplasms 21420070 C15.9 D004938 133239 HP:0100751 The expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was associated with the presence of lymph node metastasis. other hsa-mir-126 Essential Hypertension 24794206 cardiovascular system disease DOID:10825 I10 C562386 145500 MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. other hsa-mir-9 Essential Hypertension 24794206 cardiovascular system disease DOID:10825 I10 C562386 145500 MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. other hsa-mir-124 Ewing Sarcoma 28055964 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 miR-124 represses the mesenchymal features and suppresses metastasis in Ewing sarcoma. other hsa-mir-125b Ewing Sarcoma 26782555 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 Circulating miR-125b as a biomarker of Ewing's sarcoma in Chinese children. other hsa-mir-145 Ewing Sarcoma 21217773 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma. other hsa-mir-145 Ewing Sarcoma 20382729 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. other hsa-mir-34a Ewing Sarcoma 25015333 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 By demonstrating its relationship with clinical outcome, we propose evaluation of miR-34a at diagnosis of EWS patients to allow early risk stratification. Validation of these results would nonetheless ultimately need a prospective assessment. other hsa-mir-34a Ewing Sarcoma 21960059 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 miR-34a and miR490-3p achieved sufficient statistical power to predict prognosis.Patients with the highest expression of miR-34a did not experience adverse events in 5 years; in contrast, patients with the lowest expression recurred within two years. other hsa-mir-34a Ewing Sarcoma 26616853 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 CD99 counteracts EWS-FLI1 in controlling NF-κB signaling through the miR-34a other hsa-mir-490 Ewing Sarcoma 21960059 musculoskeletal system disease DOID:3369 D012512 612219 HP:0012254 miR-34a and miR490-3p achieved sufficient statistical power to predict prognosis. other hsa-mir-181c Fanconi Anemia 22310912 hematopoietic system disease DOID:13636 D61.09 D005199 PS227650 Downregulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFж┿regulation and proliferation of hematopoietic progenitor cells. other hsa-mir-130a Fatty Liver [unspecific] 24677715 disease of metabolism DOID:9452 K76.0 D005234 613282 HP:0001397 A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. other hsa-mir-29a Fatty Liver [unspecific] 28167804 disease of metabolism DOID:9452 K76.0 D005234 613282 HP:0001397 miR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus). other hsa-mir-122 Fatty Liver, Non-Alcoholic 24973316 disease of metabolism DOID:0080208 K75.81 D065626 613282 miR-122 plays a role of physiological significance in the biology of NAFLD; circulating miRNAs mirror the histological and molecular events occurring in the liver. NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk. other hsa-mir-122 Fatty Liver, Non-Alcoholic 25117675 disease of metabolism DOID:0080208 K75.81 D065626 613282 Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis. other hsa-mir-122 Fatty Liver, Non-Alcoholic 25470250 disease of metabolism DOID:0080208 K75.81 D065626 613282 Finally, the liver appears to be an important source of circulating EVs in NAFLD animals as evidenced by the enrichment in blood with miR-122 and 192--two microRNAs previously described in chronic liver diseases, coupled with a corresponding decrease in expression of these microRNAs in the liver. other hsa-mir-122 Fatty Liver, Non-Alcoholic 27669236 disease of metabolism DOID:0080208 K75.81 D065626 613282 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. other hsa-mir-33a Fatty Liver, Non-Alcoholic 27669236 disease of metabolism DOID:0080208 K75.81 D065626 613282 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. other hsa-mir-33b Fatty Liver, Non-Alcoholic 27669236 disease of metabolism DOID:0080208 K75.81 D065626 613282 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. other hsa-mir-17 Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-17 Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-17 Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-17 Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-18 Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-18 Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-18 Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-18 Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-19a Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-19a Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-19a Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-19a Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-19b-1 Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-19b-1 Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-19b-1 Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-19b-1 Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-20a Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-20a Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-20a Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-20a Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-92-1 Feingold Syndrome 23495052 genetic disease DOID:0060464 Q87.8 C537734 PS164280 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. other hsa-mir-92-1 Feingold Syndrome 24511118 genetic disease DOID:0060464 Q87.8 C537734 PS164280 MicroRNA-17~92 is required for nephrogenesis and renal function. other hsa-mir-92-1 Feingold Syndrome 26026879 genetic disease DOID:0060464 Q87.8 C537734 PS164280 respectively, of miR-17-92∆/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission other hsa-mir-92-1 Feingold Syndrome 29636449 genetic disease DOID:0060464 Q87.8 C537734 PS164280 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. other hsa-mir-153 Fetal Alcohol Spectrum Disorder 24313161 disease of mental health DOID:0050696 D063647 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. other hsa-mir-21 Fetal Alcohol Spectrum Disorder 24313161 disease of mental health DOID:0050696 D063647 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. other hsa-mir-335 Fetal Alcohol Spectrum Disorder 24313161 disease of mental health DOID:0050696 D063647 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. other hsa-mir-9 Fetal Alcohol Spectrum Disorder 24313161 disease of mental health DOID:0050696 D063647 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. other hsa-mir-196a Focal Segmental Glomerulosclerosis 25107948 urinary system disease DOID:1312 N04.1 D005923 PS603278 HP:0000097 The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity. other hsa-mir-30a Focal Segmental Glomerulosclerosis 25107948 urinary system disease DOID:1312 N04.1 D005923 PS603278 HP:0000097 The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity. other hsa-mir-490 Focal Segmental Glomerulosclerosis 25107948 urinary system disease DOID:1312 N04.1 D005923 PS603278 HP:0000097 The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity. other hsa-mir-29 Fuchs Endothelial Dystrophy 24334445 nervous system disease DOID:11555 H18.51 D005642 136800 Decreased endothelial expression of miR-29 family members may be associated with increased subendothelial extracellular matrix accumulation in FECD. other hsa-mir-210 Gallstones 25639987 K80.20 D042882 600803 HP:0001081 An integrated analysis of differential miRNA and mRNA expressions in human gallstones. other hsa-mir-203a Gastric Cardia Adenocarcinoma 27791400 disease of cellular proliferation DOID:6271 Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. other hsa-let-7g Gastric Neoplasms 19948396 disease of cellular proliferation DOID:10534 C16 D013274 137215 different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1 other hsa-mir-1 Gastric Neoplasms 27349337 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-1, -133 and -206 family in GC other hsa-mir-1 Gastric Neoplasms 28493075 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer. other hsa-mir-100 Gastric Neoplasms 25703026 disease of cellular proliferation DOID:10534 C16 D013274 137215 The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells. other hsa-mir-100 Gastric Neoplasms 20022810 disease of cellular proliferation DOID:10534 C16 D013274 137215 progression-related signature, miR-125b, miR-199a, and miR-100 were the most important microRNAs involved other hsa-mir-101-2 Gastric Neoplasms 26458815 disease of cellular proliferation DOID:10534 C16 D013274 137215 Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells. other hsa-mir-106 Gastric Neoplasms 24643999 disease of cellular proliferation DOID:10534 C16 D013274 137215 Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study. other hsa-mir-106a Gastric Neoplasms 26722506 disease of cellular proliferation DOID:10534 C16 D013274 137215 Diagnostic significance of miR-106a in gastric cancer. other hsa-mir-106a Gastric Neoplasms 18996190 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-106a: oncogenic activity other hsa-mir-10a Gastric Neoplasms 22969895 disease of cellular proliferation DOID:10534 C16 D013274 137215 miRNA expression profile in primary gastric cancers and paired lymph node metastases indicates that miR-10a plays a role in metastasis from primary gastric cancer to lymph nodes. other hsa-mir-10b Gastric Neoplasms 26311318 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-10b promotes migration and invasion through Hoxd10 in human gastric cancer cell lines and may play an important role in tumorigenesis,progression, and prognosis. other hsa-mir-1228 Gastric Neoplasms 23554909 disease of cellular proliferation DOID:10534 C16 D013274 137215 Restoration of miR-1228* Expression Suppresses Epithelial-Mesenchymal Transition in Gastric Cancer other hsa-mir-1234 Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-125a Gastric Neoplasms 22322911 disease of cellular proliferation DOID:10534 C16 D013274 137215 Low expression levels of miR-125a-3p were associated with indicators of enhanced malignant potential such as tumor size (p=0.0002), tumor invasion (p=0.0149), lymph node metastasis (p=0.018), liver metastasis (p=0.016), peritoneal dissemination (p=0.03), advanced clinical stage (p=0.0037) and poor prognosis (p=0.0083). other hsa-mir-125b-1 Gastric Neoplasms 23128435 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells other hsa-mir-125b-2 Gastric Neoplasms 26458815 disease of cellular proliferation DOID:10534 C16 D013274 137215 Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells. other hsa-mir-125b-2 Gastric Neoplasms 23128435 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells other hsa-mir-126 Gastric Neoplasms 20619534 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-126:miR-126 functions as a tumour suppressor in human gastric cancer other hsa-mir-127 Gastric Neoplasms 23880861 disease of cellular proliferation DOID:10534 C16 D013274 137215 The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. other hsa-mir-129 Gastric Neoplasms 24055727 disease of cellular proliferation DOID:10534 C16 D013274 137215 Growth inhibitory effects of three miR-129 family members on gastric cancer. other hsa-mir-129-2 Gastric Neoplasms 20331975 disease of cellular proliferation DOID:10534 C16 D013274 137215 We also found that inactivation of SOX4 by siRNA and restoration of miR-129-2 induced apoptosis in gastric cancer cells. other hsa-mir-133 Gastric Neoplasms 27349337 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-1, -133 and -206 family in GC other hsa-mir-133a Gastric Neoplasms 25780292 disease of cellular proliferation DOID:10534 C16 D013274 137215 Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. other hsa-mir-135a Gastric Neoplasms 25322930 disease of cellular proliferation DOID:10534 C16 D013274 137215 Regulation of BGC-823 cell sensitivity to adriamycin via miRNA-135a-5p. other hsa-mir-135b Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-135b Gastric Neoplasms 23328512 disease of cellular proliferation DOID:10534 C16 D013274 137215 Quantitative real-time PCR was used to validate the reliability of microarray and detect miR-135b expression in the above clinical samples, as well as cell lines GES-1, BGC-823 and SGC-7901. other hsa-mir-143 Gastric Neoplasms 25656032 disease of cellular proliferation DOID:10534 C16 D013274 137215 Expression of miR-143 and miR-145 and their functional study in gastric carcinoma. other hsa-mir-145 Gastric Neoplasms 26010149 disease of cellular proliferation DOID:10534 C16 D013274 137215 Reverse Correlation between MicroRNA-145 and FSCN1 Affecting Gastric Cancer Migration and Invasion. other hsa-mir-145 Gastric Neoplasms 25656032 disease of cellular proliferation DOID:10534 C16 D013274 137215 Expression of miR-143 and miR-145 and their functional study in gastric carcinoma. other hsa-mir-146a Gastric Neoplasms 25081668 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells. other hsa-mir-146a Gastric Neoplasms 21947847 disease of cellular proliferation DOID:10534 C16 D013274 137215 H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. other hsa-mir-146a Gastric Neoplasms 28987948 disease of cellular proliferation DOID:10534 C16 D013274 137215 MiR-146a functions as a small silent player in gastric cancer. other hsa-mir-148 Gastric Neoplasms 25261463 disease of cellular proliferation DOID:10534 C16 D013274 137215 Polymorphisms and haplotypes of the miR-148/152 family are associated with the risk and clinicopathological features of gastric cancer in a Northern Chinese population. other hsa-mir-148a Gastric Neoplasms 23869555 disease of cellular proliferation DOID:10534 C16 D013274 137215 Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development. other hsa-mir-148a Gastric Neoplasms 23873106 disease of cellular proliferation DOID:10534 C16 D013274 137215 microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition. other hsa-mir-152 Gastric Neoplasms 25261463 disease of cellular proliferation DOID:10534 C16 D013274 137215 Polymorphisms and haplotypes of the miR-148/152 family are associated with the risk and clinicopathological features of gastric cancer in a Northern Chinese population. other hsa-mir-155 Gastric Neoplasms 19702585 disease of cellular proliferation DOID:10534 C16 D013274 137215 possible role in the intimate relationship other hsa-mir-155 Gastric Neoplasms 29675003 disease of cellular proliferation DOID:10534 C16 D013274 137215 Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers other hsa-mir-16 Gastric Neoplasms 25897338 disease of cellular proliferation DOID:10534 C16 D013274 137215 Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. other hsa-mir-16 Gastric Neoplasms 21081469 disease of cellular proliferation DOID:10534 C16 D013274 137215 NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. other hsa-mir-16 Gastric Neoplasms 27157613 disease of cellular proliferation DOID:10534 C16 D013274 137215 MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. other hsa-mir-181b Gastric Neoplasms 19948396 disease of cellular proliferation DOID:10534 C16 D013274 137215 different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1 other hsa-mir-181c Gastric Neoplasms 23425811 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-181c expression level was significantly related to several clinicopathological features of gastric cancer other hsa-mir-185 Gastric Neoplasms 24352663 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer. other hsa-mir-18a Gastric Neoplasms 26772615 disease of cellular proliferation DOID:10534 C16 D013274 137215 Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. other hsa-mir-194-1 Gastric Neoplasms 21845495 disease of cellular proliferation DOID:10534 C16 D013274 137215 There is an inverse Association between miR-194 Expression and Tumor Invasion in Gastric Cancer. other hsa-mir-194-2 Gastric Neoplasms 21845495 disease of cellular proliferation DOID:10534 C16 D013274 137215 There is an inverse Association between miR-194 Expression and Tumor Invasion in Gastric Cancer. other hsa-mir-196b Gastric Neoplasms 24222951 disease of cellular proliferation DOID:10534 C16 D013274 137215 Co-activation of miR-196b and HOXA10 characterized a poor-prognosis subgroup of patients with gastric cancer. Elucidation of the biologic function of miR-196b and HOXA10 is warranted. other hsa-mir-197 Gastric Neoplasms 26632693 disease of cellular proliferation DOID:10534 C16 D013274 137215 Associations of Il-1 Family-Related Polymorphisms With Gastric Cancer Risk and the Role of Mir-197 In Il-1f5 Expression. other hsa-mir-19b Gastric Neoplasms 25897338 disease of cellular proliferation DOID:10534 C16 D013274 137215 Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. other hsa-mir-200 Gastric Neoplasms 24352645 disease of cellular proliferation DOID:10534 C16 D013274 137215 We have uncovered a key microRNA regulatory network that defines the mesenchymal gastric cancer subtype significantly associated with poor overall survival in gastric cancer other hsa-mir-200 Gastric Neoplasms 25270520 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma. other hsa-mir-202 Gastric Neoplasms 23936094 disease of cellular proliferation DOID:10534 C16 D013274 137215 Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer. other hsa-mir-203 Gastric Neoplasms 27142767 disease of cellular proliferation DOID:10534 C16 D013274 137215 Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR-203. other hsa-mir-206 Gastric Neoplasms 25653235 disease of cellular proliferation DOID:10534 C16 D013274 137215 Activation of PAX3-MET pathways due to miR-206 loss promotes gastric cancer metastasis. other hsa-mir-206 Gastric Neoplasms 26186594 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway. other hsa-mir-206 Gastric Neoplasms 27349337 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-1, -133 and -206 family in GC other hsa-mir-20a Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-21 Gastric Neoplasms 24434352 disease of cellular proliferation DOID:10534 C16 D013274 137215 the effect of celastrol on apoptosis was due to miR-21 inhibiting the PI3K/Akt-dependent NF-κB pathway. other hsa-mir-21 Gastric Neoplasms 26265521 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-21: Mechanisms of Oncogenesis and its Application in Diagnosis and Prognosis of Gastric Cancer. other hsa-mir-21 Gastric Neoplasms 18794849 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-21: miR-21 plays a pivotal role in gastric cancer pathogenesis and progression other hsa-mir-21 Gastric Neoplasms 19702585 disease of cellular proliferation DOID:10534 C16 D013274 137215 possible role in the intimate relationship other hsa-mir-21 Gastric Neoplasms 21081469 disease of cellular proliferation DOID:10534 C16 D013274 137215 NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. other hsa-mir-21 Gastric Neoplasms 26772615 disease of cellular proliferation DOID:10534 C16 D013274 137215 Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. other hsa-mir-21 Gastric Neoplasms 29185784 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway other hsa-mir-21 Gastric Neoplasms 29422082 disease of cellular proliferation DOID:10534 C16 D013274 137215 CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways other hsa-mir-210 Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-210 Gastric Neoplasms 25618442 disease of cellular proliferation DOID:10534 C16 D013274 137215 MIR210 is often highly overexpressed in gastric cancer other hsa-mir-214 Gastric Neoplasms 24614175 disease of cellular proliferation DOID:10534 C16 D013274 137215 Clinicopathological significance of microRNA-214 in gastric cancer and its effect on cell biological behaviour. other hsa-mir-214 Gastric Neoplasms 29129783 disease of cellular proliferation DOID:10534 C16 D013274 137215 Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells. other hsa-mir-214 Gastric Neoplasms 29456019 disease of cellular proliferation DOID:10534 C16 D013274 137215 Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer other hsa-mir-22 Gastric Neoplasms 23786758 disease of cellular proliferation DOID:10534 C16 D013274 137215 Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis.. other hsa-mir-221 Gastric Neoplasms 24317477 disease of cellular proliferation DOID:10534 C16 D013274 137215 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. other hsa-mir-221 Gastric Neoplasms 26364844 disease of cellular proliferation DOID:10534 C16 D013274 137215 The miR-221/miR-222-RECK axis might be an important path modulating H. pylori infection-related gastric cancer development. other hsa-mir-221 Gastric Neoplasms 19702585 disease of cellular proliferation DOID:10534 C16 D013274 137215 possible role in the intimate relationship other hsa-mir-221 Gastric Neoplasms 26772615 disease of cellular proliferation DOID:10534 C16 D013274 137215 Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles. other hsa-mir-222 Gastric Neoplasms 26364844 disease of cellular proliferation DOID:10534 C16 D013274 137215 The miR-221/miR-222-RECK axis might be an important path modulating H. pylori infection-related gastric cancer development. other hsa-mir-222 Gastric Neoplasms 19702585 disease of cellular proliferation DOID:10534 C16 D013274 137215 possible role in the intimate relationship other hsa-mir-222 Gastric Neoplasms 29098549 disease of cellular proliferation DOID:10534 C16 D013274 137215 The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway. other hsa-mir-223 Gastric Neoplasms 25036956 disease of cellular proliferation DOID:10534 C16 D013274 137215 Increased microRNA-223 in Helicobacter pylori-associated gastric cancer contributed to cancer cell proliferation and migration. other hsa-mir-224 Gastric Neoplasms 24796455 disease of cellular proliferation DOID:10534 C16 D013274 137215 Effect of antisense miR-224 on gastric cancer cell proliferation and apoptosis. other hsa-mir-23b Gastric Neoplasms 25765901 disease of cellular proliferation DOID:10534 C16 D013274 137215 Reciprocal repression between TUSC7 and miR-23b in gastric cancer. other hsa-mir-23b Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-24 Gastric Neoplasms 26045155 disease of cellular proliferation DOID:10534 C16 D013274 137215 These results suggest that the measurement of miR-24 expression from formalin-fixed paraffin-embedded (FFPE) samples is useful to identify radiation-associated GC. other hsa-mir-25 Gastric Neoplasms 24643999 disease of cellular proliferation DOID:10534 C16 D013274 137215 Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study. other hsa-mir-27a Gastric Neoplasms 18789835 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-27a: MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin other hsa-mir-27a Gastric Neoplasms 19148490 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-27a: There was a correlation between mir-27a and lymph node metastasis other hsa-mir-27a Gastric Neoplasms 19702585 disease of cellular proliferation DOID:10534 C16 D013274 137215 possible role in the intimate relationship other hsa-mir-27a Gastric Neoplasms 21569481 disease of cellular proliferation DOID:10534 C16 D013274 137215 Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. other hsa-mir-27a Gastric Neoplasms 22018270 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. other hsa-mir-27a Gastric Neoplasms 23175237 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-27a inhibitors alone or in combination with perifosine suppress the growth of gastric cancer cells other hsa-mir-27b Gastric Neoplasms 22018270 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. other hsa-mir-29 Gastric Neoplasms 24643999 disease of cellular proliferation DOID:10534 C16 D013274 137215 Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study. other hsa-mir-29 Gastric Neoplasms 25634213 disease of cellular proliferation DOID:10534 C16 D013274 137215 a global mechanism for understanding the efficacious effects of cytotoxic chemotherapy in gastric cancer. other hsa-mir-29c Gastric Neoplasms 23001726 disease of cellular proliferation DOID:10534 C16 D013274 137215 The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. other hsa-mir-30b Gastric Neoplasms 26309359 disease of cellular proliferation DOID:10534 C16 D013274 137215 Our findings describe a link between miR-30b and EIF5A2, which plays an important role in mediating epithelial-mesenchymal transition. other hsa-mir-31 Gastric Neoplasms 22212233 disease of cellular proliferation DOID:10534 C16 D013274 137215 PDCD4 expression inversely correlated with miR-21 levels in gastric cancers. other hsa-mir-335 Gastric Neoplasms 22802949 disease of cellular proliferation DOID:10534 C16 D013274 137215 A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-335 (P<0.001). other hsa-mir-337 Gastric Neoplasms 24422944 disease of cellular proliferation DOID:10534 C16 D013274 137215 These findings indicate that hsa-miR-337-3p plays a role in the reduction of gastric cancer cell invasion capacity, and further studies on the mechanism of hsa-miR-337-3p in gastric cancer metastasis are warranted. other hsa-mir-33b Gastric Neoplasms 27456358 disease of cellular proliferation DOID:10534 C16 D013274 137215 Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer. other hsa-mir-340 Gastric Neoplasms 26722508 disease of cellular proliferation DOID:10534 C16 D013274 137215 Effect of miR-340 on gastric cancer cell proliferation and apoptosis. other hsa-mir-34a Gastric Neoplasms 24981249 disease of cellular proliferation DOID:10534 C16 D013274 137215 MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer. other hsa-mir-34a Gastric Neoplasms 24988056 disease of cellular proliferation DOID:10534 C16 D013274 137215 Luteolin Induces Apoptosis by Up-regulating miR-34a in Human Gastric Cancer Cells. other hsa-mir-34a Gastric Neoplasms 26745070 disease of cellular proliferation DOID:10534 C16 D013274 137215 Our study demonstrates chrysin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight gastric cancer. other hsa-mir-34a Gastric Neoplasms 18803879 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres other hsa-mir-34b Gastric Neoplasms 18803879 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres other hsa-mir-34c Gastric Neoplasms 18803879 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres other hsa-mir-375 Gastric Neoplasms 24718681 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling. other hsa-mir-376c Gastric Neoplasms 27965982 disease of cellular proliferation DOID:10534 C16 D013274 137215 hsa-miR-376c-3p Regulates Gastric Tumor Growth Both In Vitro and In Vivo. other hsa-mir-422a Gastric Neoplasms 24317477 disease of cellular proliferation DOID:10534 C16 D013274 137215 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. other hsa-mir-423 Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-429 Gastric Neoplasms 21684154 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-429 Modulates the expression of c-myc in human gastric carcinoma cells. other hsa-mir-433 Gastric Neoplasms 23880861 disease of cellular proliferation DOID:10534 C16 D013274 137215 The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. other hsa-mir-4496 Gastric Neoplasms 27265143 disease of cellular proliferation DOID:10534 C16 D013274 137215 Here, we show that rebamipide suppresses H. pylori CagA-induced 尾-catenin and its target cancer-initiating cells (C-IC) marker gene expression via upregulation of miRNA-320a and -4496. other hsa-mir-451 Gastric Neoplasms 27173190 disease of cellular proliferation DOID:10534 C16 D013274 137215 Propofol effectively inhibited proliferation and induced apoptosis in gastric cancer cells, which was partly owing to the downregulation of MMP-2 expression by miR-451. other hsa-mir-451a Gastric Neoplasms 26458815 disease of cellular proliferation DOID:10534 C16 D013274 137215 Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells. other hsa-mir-455 Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-4697 Gastric Neoplasms 26531872 disease of cellular proliferation DOID:10534 C16 D013274 137215 The expression of TM4SF5, CTD-2354A18.1 and miR-4697-3P is in balance at physiological conditions, however, the balance is disrupted by some situations, which may contribute to gastric cancer. GO analysis and Pathway analysis also showed TM4SF5 played an important role in proliferation,differentiation and apoptosis. Therefore, TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer (Tab. 2, Fig. 4, Ref. 30). other hsa-mir-4732 Gastric Neoplasms 24317477 disease of cellular proliferation DOID:10534 C16 D013274 137215 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. other hsa-mir-4739 Gastric Neoplasms 25861021 disease of cellular proliferation DOID:10534 C16 D013274 137215 These data provide a theoretical basis for the potential interaction between miRNA and the β-catenin signaling pathway in GC. other hsa-mir-4758 Gastric Neoplasms 24317477 disease of cellular proliferation DOID:10534 C16 D013274 137215 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. other hsa-mir-494 Gastric Neoplasms 24606447 disease of cellular proliferation DOID:10534 C16 D013274 137215 Cinobufacin suppresses cell proliferation via miR-494 in BGC- 823 gastric cancer cells. other hsa-mir-497 Gastric Neoplasms 24845562 disease of cellular proliferation DOID:10534 C16 D013274 137215 The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. other hsa-mir-500 Gastric Neoplasms 25595906 disease of cellular proliferation DOID:10534 C16 D013274 137215 we report the uncovering of a novel mechanism for constitutive NF-κB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer. other hsa-mir-551b Gastric Neoplasms 25623763 disease of cellular proliferation DOID:10534 C16 D013274 137215 Expression of miR-551b-3p in gastric cancer cell lines and tissues and its clinical significance. other hsa-mir-610 Gastric Neoplasms 22189055 disease of cellular proliferation DOID:10534 C16 D013274 137215 MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein. other hsa-mir-650 Gastric Neoplasms 20381459 disease of cellular proliferation DOID:10534 C16 D013274 137215 we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer other hsa-mir-7 Gastric Neoplasms 24573489 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. other hsa-mir-7-1 Gastric Neoplasms 22139078 disease of cellular proliferation DOID:10534 C16 D013274 137215 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. other hsa-mir-7-2 Gastric Neoplasms 22139078 disease of cellular proliferation DOID:10534 C16 D013274 137215 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. other hsa-mir-7-3 Gastric Neoplasms 22139078 disease of cellular proliferation DOID:10534 C16 D013274 137215 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. other hsa-mir-9 Gastric Neoplasms 25395097 disease of cellular proliferation DOID:10534 C16 D013274 137215 membranous ALCAM expression and high serum sALCAM levels are independent prognostic markers of poor survival for patients with GC, and that the overexpression of ALCAM may be due to the downregulation of miR-9. other hsa-mir-92b Gastric Neoplasms 24317477 disease of cellular proliferation DOID:10534 C16 D013274 137215 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. other hsa-mir-92b Gastric Neoplasms 25537895 disease of cellular proliferation DOID:10534 C16 D013274 137215 miR-92b promotes the migration, adhesion and invasion of human gastric cancer cell line SGC7901 by mediating epithelial-mesenchymal transition, and may accelerate tumor cell metastasis via signaling pathways other than PI3K/Akt pathway. other hsa-mir-93 Gastric Neoplasms 24643999 disease of cellular proliferation DOID:10534 C16 D013274 137215 Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study. other hsa-let-7a Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-101 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-106a Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-106a Gastrointestinal Neoplasms 22994734 D37.9 D005770 Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs other hsa-mir-107 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-122 Gastrointestinal Neoplasms 19607815 D37.9 D005770 The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers. other hsa-mir-126 Gastrointestinal Neoplasms 19951901 D37.9 D005770 We have identified a seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0.0009) and relapse-free survival (p=0.0005) of gastric cancer patients. other hsa-mir-126 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-133b Gastrointestinal Neoplasms 23196799 D37.9 D005770 Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor other hsa-mir-143 Gastrointestinal Neoplasms 19439999 D37.9 D005770 Taken together, these findings suggest that miR-143 and miR-145 act as anti-oncomirs common to gastrointestinal tumors. other hsa-mir-143 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-145 Gastrointestinal Neoplasms 29459716 D37.9 D005770 miR-145, which blocked EGFR endocytosis, prolonged EGFR membrane signaling and altered responsiveness of colon cancer cells to EGFR-targeting drugs other hsa-mir-145 Gastrointestinal Neoplasms 19439999 D37.9 D005770 Taken together, these findings suggest that miR-143 and miR-145 act as anti-oncomirs common to gastrointestinal tumors. other hsa-mir-145 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-146a Gastrointestinal Neoplasms 26211779 D37.9 D005770 miR-146a cancer susceptibility gene polymorphism is closely associated with gastrointestinal cancers. other hsa-mir-149 Gastrointestinal Neoplasms 24312386 D37.9 D005770 The present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians. other hsa-mir-17 Gastrointestinal Neoplasms 29459716 D37.9 D005770 The regulation of EGF receptor (EGFR) endocytosis by two predicted miRNAs, namely miR-17 and miR-145, was confirmed experimentally other hsa-mir-17 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-17 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-18 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-181 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-192 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-194 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-195 Gastrointestinal Neoplasms 23212612 D37.9 D005770 We demonstrated that miR-195-5p is a novel tumor suppressor miRNA and may contribute to gastric carcinogenesis. other hsa-mir-196a-1 Gastrointestinal Neoplasms 22258453 D37.9 D005770 Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors. other hsa-mir-196a-2 Gastrointestinal Neoplasms 22258453 D37.9 D005770 Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors. other hsa-mir-19a Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-19b-1 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-20a Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-21 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-21 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-21 Gastrointestinal Neoplasms 22994734 D37.9 D005770 Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs other hsa-mir-215 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-218 Gastrointestinal Neoplasms 28024574 D37.9 D005770 miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth. other hsa-mir-221 Gastrointestinal Neoplasms 22994734 D37.9 D005770 Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs other hsa-mir-30e Gastrointestinal Neoplasms 24312366 D37.9 D005770 Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer. other hsa-mir-34 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-421 Gastrointestinal Neoplasms 19802518 D37.9 D005770 miR-421 may involve in the early stage of stomach carcinogenesis and could be used as an efficient diagnostic biomarker. other hsa-mir-449 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-451a Gastrointestinal Neoplasms 19318487 D37.9 D005770 miR-451: microRNA-451 Regulates Macrophage Migration Inhibitory Factor Proliferation of Gastrointestinal Cancer Cells Production other hsa-mir-486 Gastrointestinal Neoplasms 22168593 D37.9 D005770 The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer. other hsa-mir-499 Gastrointestinal Neoplasms 24312386 D37.9 D005770 The present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians. other hsa-mir-7 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-92-1 Gastrointestinal Neoplasms 21219233 D37.9 D005770 The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors. other hsa-mir-218 Gastrointestinal Stromal Tumor 24706111 disease of cellular proliferation DOID:9253 C49.A D046152 606764 microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway. other hsa-mir-221 Gastrointestinal Stromal Tumor 25898773 disease of cellular proliferation DOID:9253 C49.A D046152 606764 miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. other hsa-mir-222 Gastrointestinal Stromal Tumor 25898773 disease of cellular proliferation DOID:9253 C49.A D046152 606764 miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. other hsa-mir-320a Gastrointestinal Stromal Tumor 24217767 disease of cellular proliferation DOID:9253 C49.A D046152 606764 MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors. other hsa-mir-221 Gastrointestinal Stromal Tumor 24674454 disease of cellular proliferation DOID:9253 C49.A D046152 606764 Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile. other hsa-mir-222 Gastrointestinal Stromal Tumor 24674454 disease of cellular proliferation DOID:9253 C49.A D046152 606764 Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile. other hsa-mir-372 Germ Cell And Embryonal Neoplasms 17695719 D49.9 D009373 273300 we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis of primary human cells that harbor both oncogenic RAS and active wild-type p53. other hsa-mir-373 Germ Cell And Embryonal Neoplasms 17695719 D49.9 D009373 273300 we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis of primary human cells that harbor both oncogenic RAS and active wild-type p53. other hsa-mir-107 Glaucoma 26149270 nervous system disease DOID:1686 H40 D005901 137750 Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course. other hsa-mir-143 Glaucoma 28424493 nervous system disease DOID:1686 H40 D005901 137750 Regulation of intraocular pressure by microRNA cluster miR-143/145. other hsa-mir-145 Glaucoma 28424493 nervous system disease DOID:1686 H40 D005901 137750 Regulation of intraocular pressure by microRNA cluster miR-143/145. other hsa-mir-149 Glaucoma 26149270 nervous system disease DOID:1686 H40 D005901 137750 Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course. other hsa-mir-21 Glaucoma 26149270 nervous system disease DOID:1686 H40 D005901 137750 Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course. other hsa-mir-450 Glaucoma 26149270 nervous system disease DOID:1686 H40 D005901 137750 Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course. other hsa-let-7a Glioblastoma 28494471 D005909 HP:0100843 Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma. other hsa-let-7b Glioblastoma 28677425 D005909 HP:0100843 IKBKE promotes glioblastoma progression by establishing the regulatory feedback loop of IKBKE/YAP1/miR-Let-7b/i. other hsa-let-7d Glioblastoma 25212824 D005909 HP:0100843 the current study is the first to demonstrate the effect of FCL on modulation of let-7d expression other hsa-let-7i Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-1 Glioblastoma 24310399 D005909 HP:0100843 Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. other hsa-mir-1 Glioblastoma 25374033 D005909 HP:0100843 Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells. other hsa-mir-103 Glioblastoma 25903655 D005909 HP:0100843 CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content. other hsa-mir-106a Glioblastoma 23416698 D005909 HP:0100843 MiR-106a is an independent prognostic marker in patients with glioblastoma other hsa-mir-10a Glioblastoma 20444541 D005909 HP:0100843 miR-10a:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells other hsa-mir-10b Glioblastoma 21471404 D005909 HP:0100843 Human glioma growth is controlled by microRNA-10b other hsa-mir-10b Glioblastoma 23307328 D005909 HP:0100843 Inhibition of miR-10b strongly reduced cell invasion and migration in glioblastoma cell and stem cell lines while overexpression of miR-10b induced cell migration and invasion other hsa-mir-10b Glioblastoma 25738367 D005909 HP:0100843 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. other hsa-mir-10b Glioblastoma 27467502 D005909 HP:0100843 Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells. other hsa-mir-10b Glioblastoma 28153089 D005909 HP:0100843 Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. other hsa-mir-1238 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-124 Glioblastoma 24954504 D005909 HP:0100843 MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. other hsa-mir-124 Glioblastoma 25753094 D005909 HP:0100843 Gap Junctions Enhance the Antiproliferative Effect of MicroRNA-124-3p in Glioblastoma Cells. other hsa-mir-124 Glioblastoma 22701651 D005909 HP:0100843 Significantly, REST is highly expressed in self-renewing tumorigenic-competent GBM cells and its knock down strongly reduces their self-renewal in vitro and tumor-initiating capacity in vivo and affects levels of miR-124 and its downstream targets. other hsa-mir-124 Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-124-1 Glioblastoma 18577219 D005909 HP:0100843 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells other hsa-mir-124-2 Glioblastoma 18577219 D005909 HP:0100843 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells other hsa-mir-124-3 Glioblastoma 18577219 D005909 HP:0100843 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells other hsa-mir-125 Glioblastoma 23835866 D005909 HP:0100843 MicroRNA-125b inhibitor sensitizes human primary glioblastoma cells to chemotherapeutic drug temozolomide on invasion. other hsa-mir-125 Glioblastoma 25903655 D005909 HP:0100843 CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content. other hsa-mir-125a Glioblastoma 25542152 D005909 HP:0100843 TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells. other hsa-mir-125b Glioblastoma 24817689 D005909 HP:0100843 MicroRNA expression signatures and their correlation with clinicopathological features in glioblastoma multiforme other hsa-mir-125b-1 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-125b-1 Glioblastoma 22711523 D005909 HP:0100843 miR-125b expression plays an essential role in the invasion of glioblastoma CD133-positive cells but not CD133-negative cells. other hsa-mir-125b-2 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-125b-2 Glioblastoma 22711523 D005909 HP:0100843 miR-125b expression plays an essential role in the invasion of glioblastoma CD133-positive cells but not CD133-negative cells. other hsa-mir-128 Glioblastoma 25017996 D005909 HP:0100843 miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma. other hsa-mir-128 Glioblastoma 27893811 D005909 HP:0100843 The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death. other hsa-mir-128 Glioblastoma 28591575 D005909 HP:0100843 MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. other hsa-mir-1280 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-128-1 Glioblastoma 21874051 D005909 HP:0100843 Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. other hsa-mir-128-1 Glioblastoma 23482671 D005909 HP:0100843 NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200 other hsa-mir-128-2 Glioblastoma 21874051 D005909 HP:0100843 Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. other hsa-mir-128-2 Glioblastoma 23482671 D005909 HP:0100843 NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200 other hsa-mir-130a Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-133 Glioblastoma 26138587 D005909 HP:0100843 Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression. other hsa-mir-137 Glioblastoma 18577219 D005909 HP:0100843 miR-137: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells other hsa-mir-137 Glioblastoma 24465609 D005909 HP:0100843 Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells. other hsa-mir-137 Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-137 Glioblastoma 25232498 D005909 HP:0100843 OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs other hsa-mir-137 Glioblastoma 27448441 D005909 HP:0100843 Furthermore, combining miR-137 and antimiR-10b synergizes with the receptor inhibitory function of aptamer carriers and prevents GSC expansion. other hsa-mir-137 Glioblastoma 27649660 D005909 HP:0100843 Circulating microRNA-137 is a potential biomarker for human glioblastoma. other hsa-mir-142 Glioblastoma 22570537 D005909 HP:0100843 Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature. other hsa-mir-143 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-143 Glioblastoma 22490015 D005909 HP:0100843 Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines. other hsa-mir-143 Glioblastoma 23376635 D005909 HP:0100843 miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells other hsa-mir-145 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-145 Glioblastoma 22490015 D005909 HP:0100843 Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines. other hsa-mir-145 Glioblastoma 23814265 D005909 HP:0100843 Our study demonstrates that miR-145 has a tumor-suppressive function in glioblastoma in that it reduces proliferation, adhesion, and invasion of glioblastoma cells, apparently by suppressing the activity of oncogenic proteins Sox9 and ADD3. Reduced levels of miR-145 may lead to neoplastic transformation and malignant progression in glioma due to unregulated activity of these proteins. other hsa-mir-145 Glioblastoma 25232498 D005909 HP:0100843 OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs other hsa-mir-145 Glioblastoma 25564360 D005909 HP:0100843 Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma. other hsa-mir-145 Glioblastoma 29521593 D005909 HP:0100843 Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells other hsa-mir-146a Glioblastoma 25326894 D005909 HP:0100843 The Downregulation of MicroRNA-146a Modulates TGF-β Signaling Pathways Activityin Glioblastoma. other hsa-mir-146a Glioblastoma 26239619 D005909 HP:0100843 Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma. other hsa-mir-146b Glioblastoma 21266476 D005909 HP:0100843 Induction of miR-146b by PDGF-BB is modulated via MAPK-dependent induction of c-fos. other hsa-mir-149 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-149 Glioblastoma 25017996 D005909 HP:0100843 miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma. other hsa-mir-15 Glioblastoma 25738367 D005909 HP:0100843 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. other hsa-mir-151 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-151a Glioblastoma 20305651 D005909 HP:0100843 significantly increases HCC cell migration and invasion in vitro and in vivo, mainly through miR-151-5p, but not through miR-151-3p other hsa-mir-153-1 Glioblastoma 21213215 D005909 HP:0100843 Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines other hsa-mir-155 Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-155 Glioblastoma 22834637 D005909 HP:0100843 A relationship between knock-down of miR-155 and re-expression of GABRA 1 protein in vivo was recently individuated. other hsa-mir-155 Glioblastoma 23512614 D005909 HP:0100843 Cytokines (IL-1β and TNFα) also induce the expression of miR-155 and miR-155*, the microRNAs crucial in immunity and inflammation-induced oncogenesis and this is dose-dependently suppressed by IRF3. other hsa-mir-16 Glioblastoma 24418124 D005909 HP:0100843 MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. other hsa-mir-16 Glioblastoma 25738367 D005909 HP:0100843 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. other hsa-mir-16-1 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-16-2 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-17 Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-17 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-17 Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-17 Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-17 Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-18 Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-18 Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-18 Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-181a Glioblastoma 27633853 D005909 HP:0100843 MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma. other hsa-mir-181a-2 Glioblastoma 20353279 D005909 HP:0100843 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients other hsa-mir-181a-2 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-181b Glioblastoma 25633526 D005909 HP:0100843 NF-κB activation by DNA damage in GBM cells confers resistance to radiation-induced death. other hsa-mir-181b-1 Glioblastoma 20353279 D005909 HP:0100843 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients other hsa-mir-181b-2 Glioblastoma 20353279 D005909 HP:0100843 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients other hsa-mir-181c Glioblastoma 20353279 D005909 HP:0100843 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients other hsa-mir-181c Glioblastoma 21895872 D005909 HP:0100843 Evaluation of the miR-181c in combination with miR-21 predicted time to progression within six months from diagnosis with 92% sensitivity and 81% specificity (p < 0.0001). The combination of miR-181c and miR-21 could be a very sensitive and specific test to identify patients at high risk of early progression after surgery. other hsa-mir-181d Glioblastoma 20353279 D005909 HP:0100843 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients other hsa-mir-182 Glioblastoma 25838542 D005909 HP:0100843 miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. other hsa-mir-183 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-18a Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-1908 Glioblastoma 26265437 D005909 HP:0100843 miRNA-1908 functions as an oncogene in glioblastoma by repressing the PTEN pathway. MiR-1908 is a potential new molecular marker for predicting the risk of recurrence and prognosis of glioblastoma. other hsa-mir-191 Glioblastoma 28178667 D005909 HP:0100843 Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells. other hsa-mir-195 Glioblastoma 20444541 D005909 HP:0100843 miR-195:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells other hsa-mir-195 Glioblastoma 21895872 D005909 HP:0100843 miR-195 (P=0.0124; log-rank test) has positively correlated with overall survival. other hsa-mir-196b Glioblastoma 21895872 D005909 HP:0100843 miR-196b (P=0.0492; log-rank test) has positively correlated with overall survival. other hsa-mir-196b Glioblastoma 22723849 D005909 HP:0100843 Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype. other hsa-mir-19a Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-19a Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-19a Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-19a Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-19b-1 Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-19b-1 Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-19b-1 Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-19b-1 Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-19b-2 Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-200 Glioblastoma 23482671 D005909 HP:0100843 NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200 other hsa-mir-200c Glioblastoma 25058589 D005909 HP:0100843 Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme. other hsa-mir-205 Glioblastoma 25736407 D005909 HP:0100843 Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis. other hsa-mir-206 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-206 Glioblastoma 27558109 D005909 HP:0100843 MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2. other hsa-mir-208a Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-208b Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-20a Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-20a Glioblastoma 20305691 D005909 HP:0100843 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures other hsa-mir-20a Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-20a Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-20a Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-20a Glioblastoma 29625108 D005909 HP:0100843 The findings of the current study demonstrate presence of the IDH1 R132H mutation in primary human glioblastoma cell lines with upregulated HIF-1α expression, downregulating c-MYC activity and resulting in a consequential decrease in miR-20a, which is responsible for cell proliferation and resistance to standard temozolomide treatment other hsa-mir-20b Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-21 Glioblastoma 18829576 D005909 HP:0100843 miR-21: MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma other hsa-mir-21 Glioblastoma 21618027 D005909 HP:0100843 A miR-21 inhibitor enhances apoptosis and reduces G(2)-M accumulation induced by ionizing radiation in human glioblastoma U251 cells. other hsa-mir-21 Glioblastoma 21895872 D005909 HP:0100843 Evaluation of the miR-181c in combination with miR-21 predicted time to progression within six months from diagnosis with 92% sensitivity and 81% specificity (p < 0.0001). The combination of miR-181c and miR-21 could be a very sensitive and specific test to identify patients at high risk of early progression after surgery. other hsa-mir-21 Glioblastoma 22528454 D005909 HP:0100843 MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide. other hsa-mir-21 Glioblastoma 22753745 D005909 HP:0100843 MicroRNA-21 inhibition enhances in vitro chemosensitivity of temozolomide-resistant glioblastoma cells. other hsa-mir-21 Glioblastoma 23201752 D005909 HP:0100843 MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma other hsa-mir-21 Glioblastoma 23482671 D005909 HP:0100843 NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200 other hsa-mir-21 Glioblastoma 25582055 D005909 HP:0100843 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. other hsa-mir-21 Glioblastoma 26559642 D005909 HP:0100843 Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells. other hsa-mir-21 Glioblastoma 24205116 D005909 HP:0100843 MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development. other hsa-mir-21 Glioblastoma 25903655 D005909 HP:0100843 CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content. other hsa-mir-21 Glioblastoma 26433199 D005909 HP:0100843 Dissociated microglia and monocytes/macrophages from tumor-bearing brains revealed increased levels of miR-21 and reduced levels of c-Myc mRNA. other hsa-mir-21 Glioblastoma 27757032 D005909 HP:0100843 Pluronic-based micelle encapsulation potentiates myricetin-induced cytotoxicity in human glioblastoma cells. other hsa-mir-21 Glioblastoma 28727188 D005909 HP:0100843 we highlighted utilization of miR-21 as diagnostic and therapeutic biomarker for GBM patients other hsa-mir-21 Glioblastoma 29023168 D005909 HP:0100843 Development and characterization of cationic solid lipid nanoparticles for co-delivery of pemetrexed and miR-21 antisense oligonucleotide to glioblastoma cells. other hsa-mir-21 Glioblastoma 23907387 D005909 HP:0100843 Furthermore, several modules associated with less well-reported molecular aberrations-such as chromosome 11 CNVs, CD40, PLXNB1 and GSTM1 methylations, and mir-21 expressions-were also validated by external information. other hsa-mir-21 Glioblastoma 25628933 D005909 HP:0100843 Dox and miR-21 inhibitor therapy can sensitize GBM resistant cells to anthracyclines by enhancing apoptosis. other hsa-mir-210 Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-219 Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-22 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-221 Glioblastoma 25582055 D005909 HP:0100843 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. other hsa-mir-221 Glioblastoma 18759060 D005909 HP:0100843 Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). other hsa-mir-221 Glioblastoma 27837435 D005909 HP:0100843 Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma. other hsa-mir-222 Glioblastoma 25582055 D005909 HP:0100843 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. other hsa-mir-222 Glioblastoma 19520829 D005909 HP:0100843 Immunohistochemical and in situ hybridization analyses of 30 primary glioblastoma tissues demonstrated that expression of Dicer, miR-222, or miR-339 was inversely associated with ICAM-1 expression. other hsa-mir-222 Glioblastoma 23099529 D005909 HP:0100843 Electrochemical detection of miRNA-222 by use of a magnetic bead-based bioassay. other hsa-mir-224 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-224 Glioblastoma 24785373 D005909 HP:0100843 MiR-224 expression increases radiation sensitivity of glioblastoma cells. other hsa-mir-24 Glioblastoma 25903655 D005909 HP:0100843 CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content. other hsa-mir-25 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-26a Glioblastoma 24211747 D005909 HP:0100843 MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated. other hsa-mir-26a-1 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-26a-2 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-29a Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-29c Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-302 Glioblastoma 25991553 D005909 HP:0100843 Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. other hsa-mir-30a Glioblastoma 21178384 D005909 HP:0100843 the transcriptional BDNF inhibitor miR-30a-5p was also overexpressed at 6 and 12 h of paroxetine incubation other hsa-mir-30c-1 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-30c-2 Glioblastoma 21961478 D005909 HP:0100843 altered expression after Polyunsaturated fatty acids (PUFAs) treatment other hsa-mir-31 Glioblastoma 26164206 D005909 HP:0100843 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma. other hsa-mir-31 Glioblastoma 29521593 D005909 HP:0100843 Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-6p co-overexpression in human mesenchymal stem cells other hsa-mir-3189 Glioblastoma 25645911 D005909 HP:0100843 Anti-tumoral effects of miR-3189-3p in glioblastoma. other hsa-mir-323a Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-323b Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-326 Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-326 Glioblastoma 27871300 D005909 HP:0100843 PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA. other hsa-mir-329-1 Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-329-2 Glioblastoma 23302469 D005909 HP:0100843 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients other hsa-mir-339 Glioblastoma 19520829 D005909 HP:0100843 Immunohistochemical and in situ hybridization analyses of 30 primary glioblastoma tissues demonstrated that expression of Dicer, miR-222, or miR-339 was inversely associated with ICAM-1 expression. other hsa-mir-340 Glioblastoma 25817794 D005909 HP:0100843 miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2. other hsa-mir-340 Glioblastoma 25831237 D005909 HP:0100843 miR-340 suppresses glioblastoma multiforme. other hsa-mir-34a Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-367 Glioblastoma 25991553 D005909 HP:0100843 Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. other hsa-mir-376a-1 Glioblastoma 23093778 D005909 HP:0100843 Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells other hsa-mir-376a-2 Glioblastoma 23093778 D005909 HP:0100843 Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells other hsa-mir-378 Glioblastoma 29081036 D005909 HP:0100843 MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. other hsa-mir-381 Glioblastoma 21435336 D005909 HP:0100843 Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. other hsa-mir-423 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-451 Glioblastoma 20816946 D005909 HP:0100843 MiRNA-451 plays a role as tumor suppressor in human glioma cells. other hsa-mir-451 Glioblastoma 22205943 D005909 HP:0100843 The model provides an explanation for the growth-invasion cycling patterns of glioma cells in response to high/low glucose uptake in microenvironment in vitro, and suggests new targets for drugs,associated with miR-451 upregulation. other hsa-mir-451 Glioblastoma 24899919 D005909 HP:0100843 Those parameters are primarily linked to the reactions that involve the microRNA-451 and the thereof regulated protein MO25. other hsa-mir-451 Glioblastoma 25833239 D005909 HP:0100843 low levels of glucose affect metabolism and activate cell migration through the miR-451-AMPK control system other hsa-mir-451 Glioblastoma 28440461 D005909 HP:0100843 The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required. other hsa-mir-451 Glioblastoma 28629521 D005909 HP:0100843 Erythropoietin Promotes Glioblastoma via miR-451 Suppression. other hsa-mir-451a Glioblastoma 23367447 D005909 HP:0100843 A computational multiscale model of glioblastoma growth: Regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK other hsa-mir-455 Glioblastoma 20444541 D005909 HP:0100843 miR-455-3p:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells other hsa-mir-491 Glioblastoma 24747968 D005909 HP:0100843 Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. other hsa-mir-494 Glioblastoma 25662849 D005909 HP:0100843 miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells. other hsa-mir-504 Glioblastoma 28056026 D005909 HP:0100843 Integration of MicroRNA, mRNA, and Protein Expression Data for the Identification of Cancer-Related MicroRNAs. other hsa-mir-513c Glioblastoma 26063413 D005909 HP:0100843 microRNA-513c suppresses the proliferation of human glioblastoma cells by repressing low-density lipoprotein receptor-related protein 6. other hsa-mir-577 Glioblastoma 25764520 D005909 HP:0100843 miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. other hsa-mir-603 Glioblastoma 24994119 D005909 HP:0100843 A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. other hsa-mir-613 Glioblastoma 28718378 D005909 HP:0100843 MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2. other hsa-mir-7 Glioblastoma 24603851 D005909 HP:0100843 miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways. other hsa-mir-7 Glioblastoma 25149532 D005909 HP:0100843 Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. other hsa-mir-7 Glioblastoma 18483236 D005909 HP:0100843 microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. other hsa-mir-7 Glioblastoma 28459998 D005909 HP:0100843 Identification of miRNA-7 by genome-wide analysis as a critical sensitizer for TRAIL-induced apoptosis in glioblastoma cells. other hsa-mir-708 Glioblastoma 23754151 D005909 HP:0100843 miR-708 acts as a tumor suppressor in human glioblastoma cells. other hsa-mir-9 Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-92-1 Glioblastoma 25677619 D005909 HP:0100843 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. other hsa-mir-92-1 Glioblastoma 20940405 D005909 HP:0100843 Together, our results define a pathway in which c-Myc activation of miR-17∼92 attenuates the TGFβ signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth. other hsa-mir-92-1 Glioblastoma 28903422 D005909 HP:0100843 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines other hsa-mir-92b Glioblastoma 22829753 D005909 HP:0100843 Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies. other hsa-mir-93 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-938 Glioblastoma 25869098 D005909 HP:0100843 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. other hsa-mir-99a Glioblastoma 23298836 D005909 HP:0100843 The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma other hsa-mir-99a Glioblastoma 23409016 D005909 HP:0100843 Photofrin Based Photodynamic Therapy and miR-99a Transfection Inhibited FGFR3 and PI3K/Akt Signaling Mechanisms to Control Growth of Human Glioblastoma In Vitro and In Vivo other hsa-mir-106a Glioma 25950430 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The Effects and Molecular Mechanisms of MiR-106a in Multidrug Resistance Reversal in Human Glioma U87/DDP and U251/G Cell Lines. other hsa-mir-106b Glioma 28431179 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. other hsa-mir-107 Glioma 23572380 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-107 Inhibits U87 Glioma Stem Cells Growth and Invasion other hsa-mir-10b Glioma 22766763 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. other hsa-mir-1227 Glioma 28091986 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration other hsa-mir-122 Glioma 24863942 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression. other hsa-mir-124 Glioma 26269187 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Our findings indicate a clear benefit in harnessing the wild-type virus replicative potency in development of next-generation oncolytic alphaviruses. other hsa-mir-124 Glioma 26530859 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 In conclusion,miR-124 was found to suppress the migration and invasion of glioma cells in vitro via Capn4. other hsa-mir-124 Glioma 23338605 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity. other hsa-mir-124-1 Glioma 22918790 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma. other hsa-mir-124-2 Glioma 22918790 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma. other hsa-mir-124a Glioma 25175832 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-124a restoration inhibits glioma cell proliferation and invasion by suppressing IQGAP1 and β-catenin. other hsa-mir-125b Glioma 26170223 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway. other hsa-mir-127 Glioma 26261488 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. other hsa-mir-127 Glioma 29805677 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-κB and microRNA-127 in human glioma U87MG cells. other hsa-mir-128 Glioma 23338605 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity. other hsa-mir-130b Glioma 28107197 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MTDH promotes glioma invasion through regulating miR-130b-ceRNAs. other hsa-mir-132 Glioma 25983322 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 TGF-β induced miR-132 enhances the activation of TGF-β signaling through inhibiting SMAD7 expression in glioma cells. other hsa-mir-135a-1 Glioma 22139076 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-135a functions as a selective killer of malignant glioma. other hsa-mir-135a-2 Glioma 22139076 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-135a functions as a selective killer of malignant glioma. other hsa-mir-138-1 Glioma 22921398 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-138 has a critical role in promoting growth and survival of bona fide tumor-initiating cells with self-renewal potential. other hsa-mir-138-2 Glioma 22921398 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-138 has a critical role in promoting growth and survival of bona fide tumor-initiating cells with self-renewal potential. other hsa-mir-140 Glioma 28443475 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma. other hsa-mir-142 Glioma 24825189 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response. other hsa-mir-142 Glioma 24974128 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 These data indicate a unique role of miR-142-3p in glioma immunity by modulating M2 macrophages through the transforming growth factor beta signaling pathway. other hsa-mir-145 Glioma 22269208 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Over-expression of miR-145 enhances the effectiveness of HSVtk gene therapy for malignant glioma. other hsa-mir-146b Glioma 26397753 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 In conclusion, the inhibition of miR-146b may increase hypoxia-induced cardiomyocyte apoptosis. other hsa-mir-146b Glioma 23338605 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity. other hsa-mir-146b Glioma 23419525 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor. other hsa-mir-155 Glioma 25672607 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-155 contributes to the progression of glioma by enhancing Wnt/β-catenin pathway. other hsa-mir-155 Glioma 28724215 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells. other hsa-mir-15b Glioma 21937590 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-15b and miR-21 were differentially expressed in CSF (cerebrospinal fluid) samples from patients with gliomas, compared to control subjects with various neurologic disorders, including patients with primary CNS lymphoma and carcinomatous brain metastases.In conclusion, the results of this pilot study demonstrate that miR-15b and miR-21 are markers for gliomas, which can be assessed in the CSF by means of qRT-PCR. other hsa-mir-15b Glioma 25811315 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Decreased Expression of miR-15b in Human Gliomas is Associated with Poor Prognosis. other hsa-mir-16 Glioma 25242314 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-16 suppresses epithelial-mesenchymal transition-related gene expression in human glioma. other hsa-mir-16 Glioma 27430517 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 apigenin inhibits glioma cell growth through promoting miR‑16 and suppression of BCL2 and NF-κB/MMP-9 other hsa-mir-17 Glioma 29351283 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The reduced miR-17 levels in glioma cells increased cell viability and migration, which correlates with increased expression of Cyclin D1, p-Akt and Akt other hsa-mir-181a-2 Glioma 18710654 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-181a: mir suppressor other hsa-mir-181b Glioma 23810250 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. other hsa-mir-181b Glioma 23554660 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells. other hsa-mir-181b-1 Glioma 18710654 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-181b: mir suppressor other hsa-mir-181b-2 Glioma 18710654 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-181b: mir suppressor other hsa-mir-182 Glioma 23252827 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas other hsa-mir-182 Glioma 23006329 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 we found that TGF-β induced miR-182 expression, leading to prolonged NF-κB activation. other hsa-mir-182 Glioma 28956430 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The feasibility of the method for sensitive determination of miRNA-182 and miRNA-381 from serum samples of glioma patients at different stages was demonstrated other hsa-mir-183 Glioma 23252827 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas other hsa-mir-183 Glioma 28184912 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines. other hsa-mir-184 Glioma 26464691 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Inhibitory effect of miR-184 on the potential of proliferation and invasion in human glioma and breast cancer cells in vitro. other hsa-mir-185 Glioma 22834685 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway. other hsa-mir-186 Glioma 28351322 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186. other hsa-mir-18a Glioma 23533157 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling other hsa-mir-192 Glioma 28039611 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. other hsa-mir-195 Glioma 27574009 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7. other hsa-mir-196a Glioma 20601442 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Our results suggest that miR-196 may play a role in the malignant progression of gliomas and may be a prognostic predictor in glioblastomas. other hsa-mir-196b Glioma 23049982 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 We have provided the first evidence that expression of miR-196b was associated with the occurrence of pre-operative seizures in low-grade gliomas,and may predict seizure prognosis in patients without pre-operative seizures other hsa-mir-196b Glioma 27821299 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Biomarkers related with seizure risk in glioma patients: A systematic review. other hsa-mir-200 Glioma 27041571 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 SHP-2 acts together with PI3K/AKT to regulate a ZEB1-miR-200 feedback loop in PDGFR伪-driven gliomas. other hsa-mir-203 Glioma 23813496 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Our data validate an important clinical significance of miR-203 in gliomas, and reveal that it might be an intrinsic regulator of tumor progression and a potential prognostic factor for this dismal disease. other hsa-mir-204 Glioma 26134825 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion. other hsa-mir-205 Glioma 27574009 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7. other hsa-mir-20a Glioma 27242439 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The expression levels of miR-20a decreased significantly after U-87 and U-251 cells were treated with EMAP-II. other hsa-mir-20a Glioma 29625108 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Oncogenic MicroRNA-20a is downregulated by the HIF-1α/c-MYC pathway in IDH1 R132H-mutant glioma other hsa-mir-21 Glioma 20514462 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-21:Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3 other hsa-mir-21 Glioma 21937590 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-15b and miR-21 were differentially expressed in CSF (cerebrospinal fluid) samples from patients with gliomas, compared to control subjects with various neurologic disorders, including patients with primary CNS lymphoma and carcinomatous brain metastases.In conclusion, the results of this pilot study demonstrate that miR-15b and miR-21 are markers for gliomas, which can be assessed in the CSF by means of qRT-PCR. other hsa-mir-21 Glioma 22766763 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. other hsa-mir-21 Glioma 23104517 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas other hsa-mir-21 Glioma 26109525 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Tamoxifen-Induced Cell Death of Malignant Glioma Cells Is Brought About by Oxidative-Stress-Mediated Alterations in the Expression of BCL2 Family Members and Is Enhanced on miR-21 Inhibition. other hsa-mir-21 Glioma 26473373 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 These results suggest that miR-21 is associated with regulation of the migratory ability and survival in human glioma cells. These findings suggest novel mechanisms of malignancy and new potential combinatorial strategies for the management of malignant glioma. other hsa-mir-21 Glioma 26121981 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. other hsa-mir-21 Glioma 23810250 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. other hsa-mir-21 Glioma 19934272 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 the results of our study show that the downregulation of miR-21 contributes to the antitumor effects of IFN-beta and that miR-21 expression is negatively regulated by STAT3 activation. These results highlight the importance of understanding the transcriptional regulation of the miRNAs involved in oncogenesis. other hsa-mir-21 Glioma 25510379 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 An independent meta-analysis of five included studies was conducted to evaluate the diagnostic efficacy of miR-21 in patients with glioma other hsa-mir-21 Glioma 26433199 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Dissociated microglia and monocytes/macrophages from tumor-bearing brains revealed increased levels of miR-21 and reduced levels of c-Myc mRNA. other hsa-mir-21 Glioma 27504157 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Our data showed that in 1321N1 cells, E2-adrenergic-Epac pathway stimulation up and down-regulated Cx43 and miR-21 expression respectively. other hsa-mir-21 Glioma 27909726 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling. other hsa-mir-21 Glioma 28208619 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells. other hsa-mir-21 Glioma 28431179 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. other hsa-mir-214 Glioma 24277415 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Combined aberrant expression of microRNA-214 and UBC9 is an independent unfavorable prognostic factor for patients with gliomas. other hsa-mir-218 Glioma 26572167 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-218-5p inhibits the stem cell properties and invasive ability of the A2B5+CD133- subgroup of human glioma stem cells. other hsa-mir-218 Glioma 23338605 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity. other hsa-mir-218 Glioma 28039611 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. other hsa-mir-219 Glioma 28431179 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. other hsa-mir-222 Glioma 28091986 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration other hsa-mir-23b Glioma 24503899 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo. other hsa-mir-26a Glioma 19487573 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. other hsa-mir-26a Glioma 28431179 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. other hsa-mir-29c Glioma 23943502 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis. other hsa-mir-29c Glioma 23744344 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Tumor-suppressive effects of miR-29c on gliomas. other hsa-mir-300 Glioma 24464870 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells. other hsa-mir-30a Glioma 26255203 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-30a-5p is induced by Wnt/β-catenin pathway and promotes glioma cell invasion by repressing NCAM. other hsa-mir-30a Glioma 28192116 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway. other hsa-mir-30e Glioma 22156201 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-ж╩B/Iж╩Bж┿negative feedback loop. other hsa-mir-32 Glioma 28091986 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration other hsa-mir-323 Glioma 26656446 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiRNA-323-5p inhibited human cerebral glioma U373 cell proliferation and promoted its apoptosis by reducing IGF-1R. other hsa-mir-326 Glioma 26183397 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. other hsa-mir-328 Glioma 24305703 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-328 promotes glioma cell invasion via SFRP1-dependent Wnt-signaling activation. other hsa-mir-335 Glioma 22172575 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-335 is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/PKA Pathway. other hsa-mir-338 Glioma 28431179 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. other hsa-mir-33a Glioma 25202981 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. other hsa-mir-342 Glioma 28112756 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p. other hsa-mir-34a Glioma 20190569 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 microRNA-34a is tumor suppressive in brain tumors and glioma stem cells other hsa-mir-34a Glioma 22568628 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem Cells. other hsa-mir-34a Glioma 23529798 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 These findings indicate the role of miR-34a in tumor progression may be closely associated with p53 mutation and inversely correlated to Bcl-2 expression other hsa-mir-34a Glioma 27268916 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-34a was downregulated under hypoxia but upregulated by resveratrol other hsa-mir-376 Glioma 26940843 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MIR376 as an important microRNA family for cancer formation and progression other hsa-mir-381 Glioma 28956430 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The feasibility of the method for sensitive determination of miRNA-182 and miRNA-381 from serum samples of glioma patients at different stages was demonstrated other hsa-mir-429 Glioma 26272601 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Our results indicated that BMK1 modulation by miR-429 has an important function in glioma invasion both in vitro and in vivo. other hsa-mir-451 Glioma 24714982 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Selective β2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac. other hsa-mir-451a Glioma 25629604 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Effective control of growing cells near BV sites in addition to relocalization of invisible migratory cells back to the resection site was suggested as a way of eradicating these migratory cells. other hsa-mir-451a Glioma 20227367 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells other hsa-mir-508 Glioma 28121353 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 MiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma. other hsa-mir-524 Glioma 24194606 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. other hsa-mir-603 Glioma 25681036 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1. other hsa-mir-628 Glioma 24194606 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. other hsa-mir-637 Glioma 27840895 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Sevoflurane inhibits the migration and invasion of glioma cells by upregulating microRNA-637. other hsa-mir-7-1 Glioma 23373996 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo other hsa-mir-7-1 Glioma 23404538 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells other hsa-mir-7-2 Glioma 23373996 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo other hsa-mir-7-2 Glioma 23404538 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells other hsa-mir-7-3 Glioma 23373996 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo other hsa-mir-7-3 Glioma 23404538 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells other hsa-mir-9 Glioma 27975329 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 Density-Dependent Regulation of Glioma Cell Proliferation and Invasion Mediated by miR-9. other hsa-mir-92a Glioma 25342742 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 We conclude that glioma-derived miR-92a induces IL-6(+) IL-10(+) NKT cells; this fraction of NKT cells can suppress cytotoxic CD8(+) T cells. other hsa-mir-93 Glioma 25823655 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. other hsa-mir-96 Glioma 23252827 disease of cellular proliferation DOID:3070 D005910 PS137800 HP:0009733 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas other hsa-mir-21 Gliosis 20130193 D005911 HP:0002171 We find that the two receptors exert opposing effects on the posttranscriptional regulation of astrocytic microRNA-21. other hsa-mir-135 Glomerulonephritis 26134897 urinary system disease DOID:2921 N05 D005921 305800 HP:0000099 miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling. other hsa-mir-148b Glomerulonephritis 22362909 urinary system disease DOID:2921 N05 D005921 305800 HP:0000099 Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy. other hsa-mir-30 Glomerulonephritis 24029422 urinary system disease DOID:2921 N05 D005921 305800 HP:0000099 Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. other hsa-mir-140 Gout 27727249 musculoskeletal system disease DOID:13189 M10 D006073 HP:0001997 microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1β-induced Osteoarthritis. other hsa-mir-140 Gout 28647469 musculoskeletal system disease DOID:13189 M10 D006073 HP:0001997 Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. other hsa-mir-146a Gout 25646371 musculoskeletal system disease DOID:13189 M10 D006073 HP:0001997 Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. other hsa-mir-146a Graft-Versus-Host Disease 28853768 D89.813 D006086 614395 Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease. other hsa-mir-155 Graft-Versus-Host Disease 28423578 D89.813 D006086 614395 Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. other hsa-mir-21 Graft-Versus-Host Disease 26631756 D89.813 D006086 614395 MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus. other hsa-mir-21 Graft-Versus-Host Disease 28396121 D89.813 D006086 614395 Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction. other hsa-mir-663 Graft-Versus-Host Disease 27063175 D89.813 D006086 614395 Role of miR-663 in acute renal graft rejection: an in vitro study. other hsa-mir-132 Granulosa Cell Tumor 26282993 disease of cellular proliferation DOID:2999 D006106 Our findings suggest that miR-132 is involved in the cAMP signaling pathway and promotes estradiol synthesis via the translational repression of Nurr1 in ovarian GCs. other hsa-mir-21 Granulosa Cell Tumor 20357270 disease of cellular proliferation DOID:2999 D006106 MicroRNA 21 Blocks Apoptosis in Mouse Periovulatory Granulosa Cells other hsa-mir-23a Granulosa Cell Tumor 26400397 disease of cellular proliferation DOID:2999 D006106 These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be used for future clinical applications. other hsa-mir-27a Granulosa Cell Tumor 26400397 disease of cellular proliferation DOID:2999 D006106 These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be used for future clinical applications. other hsa-mir-346 Graves Disease 28192819 immune system disease DOID:12361 E05.00 D006111 275000 HP:0100647 MiR-346 and TRAb as Predicative Factors for Relapse in Graves' Disease Within One Year. other hsa-mir-101 Graves Disease 25871842 immune system disease DOID:12361 E05.00 D006111 275000 HP:0100647 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. other hsa-mir-146a Graves Ophthalmopathy 24743332 E05.00 D049970 Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy. other hsa-mir-146a Graves Ophthalmopathy 25100151 E05.00 D049970 Circulating levels of miR-146a and IL-17 are significantly correlated with the clinical activity of Graves' ophthalmopathy. other hsa-mir-155 Graves Ophthalmopathy 24743332 E05.00 D049970 Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy. other hsa-mir-122 Growth Disorders 26198739 M89.20 D006130 Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA other hsa-mir-15 Growth Disorders 26198739 M89.20 D006130 Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA other hsa-mir-16 Growth Disorders 26198739 M89.20 D006130 Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA other hsa-mir-21 Growth Disorders 26198739 M89.20 D006130 Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA other hsa-mir-503 Growth Disorders 26198739 M89.20 D006130 Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA other hsa-mir-125b-1 Hailey-Hailey Disease 21913998 integumentary system disease DOID:0050429 Q82.8 D016506 169600 Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation. other hsa-mir-140 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-143 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-148a Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-324 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-362 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-545 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-628 Hand, Foot And Mouth Disease 22087245 disease by infectious agent DOID:10881 B08.4 D006232 A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761. other hsa-mir-151 Hantavirus Infection 24074584 B33.4 D018778 Our data suggest that differential immune responses following hantavirus infection may be regulated in part by cellular miRNA through dysregulation of genes critical to the inflammatory process. other hsa-mir-1973 Hantavirus Infection 24074584 B33.4 D018778 Our data suggest that differential immune responses following hantavirus infection may be regulated in part by cellular miRNA through dysregulation of genes critical to the inflammatory process. other hsa-let-7a-1 Head And Neck Neoplasms 21292542 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. other hsa-let-7a-2 Head And Neck Neoplasms 21292542 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. other hsa-let-7a-3 Head And Neck Neoplasms 21292542 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. other hsa-mir-107 Head And Neck Neoplasms 22491216 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Lipid-based Nanoparticle Delivery of Pre-miR-107 Inhibits the Tumorigenicity of Head and Neck Squamous Cell Carcinoma. other hsa-mir-10b Head And Neck Neoplasms 24209638 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 The study of microRNA alterations in HNSCC is an essential step to the mechanistic understanding of tumor formation and could lead to the discovery of clinically relevant biomarkers. other hsa-mir-138-1 Head And Neck Neoplasms 23445815 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Role of microRNA-138 as a Potential Tumor Suppressor in Head and Neck Squamous Cell Carcinoma other hsa-mir-138-2 Head And Neck Neoplasms 23445815 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Role of microRNA-138 as a Potential Tumor Suppressor in Head and Neck Squamous Cell Carcinoma other hsa-mir-196a Head And Neck Neoplasms 24209638 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 The study of microRNA alterations in HNSCC is an essential step to the mechanistic understanding of tumor formation and could lead to the discovery of clinically relevant biomarkers. other hsa-mir-200c Head And Neck Neoplasms 21294122 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. other hsa-mir-204 Head And Neck Neoplasms 20369013 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis other hsa-mir-7-1 Head And Neck Neoplasms 23115635 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 other hsa-mir-7-2 Head And Neck Neoplasms 23115635 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 other hsa-mir-7-3 Head And Neck Neoplasms 23115635 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 other hsa-mir-9-1 Head And Neck Neoplasms 22664743 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 other hsa-mir-9-2 Head And Neck Neoplasms 22664743 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 other hsa-mir-9-3 Head And Neck Neoplasms 22664743 disease of cellular proliferation DOID:11934 C76.0 D006258 HP:0012288 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 other hsa-mir-34a Hearing Loss 28756190 H91.93 D034381 miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis. other hsa-mir-1 Heart Diseases [unspecific] 25177824 I51.9 D006333 miRNA-1: functional roles and dysregulation in heart disease. other hsa-mir-122 Heart Diseases [unspecific] 28287427 I51.9 D006333 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. other hsa-mir-184 Heart Diseases [unspecific] 28287427 I51.9 D006333 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. other hsa-mir-21 Heart Diseases [unspecific] 17786230 I51.9 D006333 Another miRNA consistently induced by cardiac stress, miR-21, appears to function as a regulator of cardiac growth and fetal gene activation in primary cardiomyocytes in vitro although some confusion remains regarding its exact role. other hsa-mir-34a Heart Diseases [unspecific] 23047694 I51.9 D006333 Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. other hsa-mir-34a Heart Diseases [unspecific] 28287427 I51.9 D006333 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. other hsa-mir-1 Heart Failure 19149547 I50 D006331 HP:0001635 miR-133 and miR-1 are specifically expressed in cardiac and skeletal muscle and control myogenesis, cardiac development, cardiac performance and cardiomyocyte hypertrophy (mainly by tuning transcription factors and other growth-related targets). other hsa-mir-1 Heart Failure 19320780 I50 D006331 HP:0001635 The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy. other hsa-mir-1 Heart Failure 19519553 I50 D006331 HP:0001635 MiR-1 influences susceptibility to cardiac arrhythmias after myocardial infarction. other hsa-mir-1 Heart Failure 22110643 I50 D006331 HP:0001635 We conclude that miR-1 and -499 play differential roles in cardiac differentiation of hESCs in a context-dependent fashion. While miR-499 promotes ventricular specification of hESCs, miR-1 serves to facilitate electrophysiological maturation. other hsa-mir-1 Heart Failure 22326846 I50 D006331 HP:0001635 These findings demonstrate the importance of miR-1 in cardiac function and in the pathogenesis of heart failure via Sorcin-dependent calcium homeostasis. other hsa-mir-1 Heart Failure 29117535 I50 D006331 HP:0001635 Rescuing infusion of miRNA-1 prevents cardiac remodeling in a heart-selective miRNA deficient mouse. other hsa-mir-100 Heart Failure 18582896 I50 D006331 HP:0001635 To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes. other hsa-mir-1-1 Heart Failure 22163007 I50 D006331 HP:0001635 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. other hsa-mir-1-1 Heart Failure 22362515 I50 D006331 HP:0001635 SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. other hsa-mir-1-2 Heart Failure 22163007 I50 D006331 HP:0001635 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. other hsa-mir-1-2 Heart Failure 22362515 I50 D006331 HP:0001635 SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. other hsa-mir-125b Heart Failure 25763857 I50 D006331 HP:0001635 Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells. other hsa-mir-125b Heart Failure 22545159 I50 D006331 HP:0001635 These studies identified miR-125b as an important regulator of hESC differentiation in general, and the development of hESC-derived mesoderm and cardiac muscle in particular. other hsa-mir-126 Heart Failure 26313139 I50 D006331 HP:0001635 Biological significance of miR-126 expression in atrial fibrillation and heart failure. other hsa-mir-126 Heart Failure 23465244 I50 D006331 HP:0001635 Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients other hsa-mir-126 Heart Failure 19320780 I50 D006331 HP:0001635 The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy. other hsa-mir-126 Heart Failure 27180261 I50 D006331 HP:0001635 miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation. other hsa-mir-132 Heart Failure 29027324 I50 D006331 HP:0001635 Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure. other hsa-mir-133 Heart Failure 19149547 I50 D006331 HP:0001635 miR-133 and miR-1 are specifically expressed in cardiac and skeletal muscle and control myogenesis, cardiac development, cardiac performance and cardiomyocyte hypertrophy (mainly by tuning transcription factors and other growth-related targets). other hsa-mir-133 Heart Failure 19320780 I50 D006331 HP:0001635 The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy. other hsa-mir-133a Heart Failure 19056878 I50 D006331 HP:0001635 It will be interesting to see, if miR-133a is also involved in human heart diseases, especially VSD and dilated cardiomyopathy. other hsa-mir-133a Heart Failure 28283551 I50 D006331 HP:0001635 A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure. other hsa-mir-133a-1 Heart Failure 19096030 I50 D006331 HP:0001635 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-133a-1 Heart Failure 22163007 I50 D006331 HP:0001635 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. other hsa-mir-133a-2 Heart Failure 19096030 I50 D006331 HP:0001635 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-133a-2 Heart Failure 22163007 I50 D006331 HP:0001635 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. other hsa-mir-133b Heart Failure 19096030 I50 D006331 HP:0001635 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-133b Heart Failure 22163007 I50 D006331 HP:0001635 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. other hsa-mir-133b Heart Failure 18582896 I50 D006331 HP:0001635 To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes. other hsa-mir-135a Heart Failure 21185128 I50 D006331 HP:0001635 Possible involvement of microRNAs (miR-135a∗) in heart failure associated with 25bp deletion in MYBPC3 (cardiac myosin binding protein C) gene. other hsa-mir-142 Heart Failure 26327117 I50 D006331 HP:0001635 miR-142-5p has been proposed to control adaptive growth in cardiomyocytes postnatally and its increase is associated with extensive apoptosis and cardiac dysfunction in a murine heart failure model. other hsa-mir-150 Heart Failure 24462065 I50 D006331 HP:0001635 Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure. other hsa-mir-16 Heart Failure 25763857 I50 D006331 HP:0001635 Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells. other hsa-mir-181c Heart Failure 27742689 I50 D006331 HP:0001635 Role of microRNA in metabolic shift during heart failure. other hsa-mir-195 Heart Failure 22190509 I50 D006331 HP:0001635 microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. other hsa-mir-199a-1 Heart Failure 20965886 I50 D006331 HP:0001635 Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart other hsa-mir-199a-2 Heart Failure 20965886 I50 D006331 HP:0001635 Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart other hsa-mir-19b Heart Failure 27805004 I50 D006331 HP:0001635 miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. other hsa-mir-19b Heart Failure 28091585 I50 D006331 HP:0001635 MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure. other hsa-mir-205 Heart Failure 28849082 I50 D006331 HP:0001635 Short‑term vagus nerve stimulation reduces myocardial apoptosis by downregulating microRNA‑205 in rats with chronic heart failure. other hsa-mir-206 Heart Failure 24465270 I50 D006331 HP:0001635 Provide a complex overview of microRNA-206. other hsa-mir-206 Heart Failure 23242657 I50 D006331 HP:0001635 Recent data indicate that these miRNAs as well as miR-206 change their expression quickly in response to physical activity. other hsa-mir-208 Heart Failure 19519553 I50 D006331 HP:0001635 MiR-208 is involved in the shift toward a fetal gene expression pattern in contractile proteins in heart failure. other hsa-mir-208 Heart Failure 23839576 I50 D006331 HP:0001635 Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity. other hsa-mir-208 Heart Failure 25840809 I50 D006331 HP:0001635 miR-208 family is closely associated with the development of cardiac diseases other hsa-mir-208b Heart Failure 24714087 I50 D006331 HP:0001635 These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure. other hsa-mir-21 Heart Failure 25763857 I50 D006331 HP:0001635 Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells. other hsa-mir-21 Heart Failure 19519553 I50 D006331 HP:0001635 MiR-29 is involved in fibrotic reaction after myocardial infarction while miR-21 may exert a fundamental role in post-angioplasty restenosis. other hsa-mir-21 Heart Failure 22529925 I50 D006331 HP:0001635 Transfection assay revealed that both Ago1 and Ago2 synergistically induced miR-21 and miR-21* when the mir-21 plasmid was co-transfected with either. other hsa-mir-21 Heart Failure 22842854 I50 D006331 HP:0001635 TMZ improved RV function (as indicated by an increase in tricuspid annular plane systolic excursion), and inhibited fibrosis. TMZ also protects RVMCs againts apoptosis and increases miR-21 expression. other hsa-mir-21 Heart Failure 24743143 I50 D006331 HP:0001635 In particular, a passenger strand miR, miR-21*, was identified as a potent paracrine factor that induces cardiomyocyte hypertrophy when shuttled through exosomes. other hsa-mir-21 Heart Failure 25903305 I50 D006331 HP:0001635 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. other hsa-mir-21 Heart Failure 26047574 I50 D006331 HP:0001635 Torasemide but not furosemide inhibits CYP11B2 activity and reduces the expression of CTGF, LOX, and miR-21. other hsa-mir-21 Heart Failure 27292200 I50 D006331 HP:0001635 heart failure (miR-21 and miR-133a) other hsa-mir-210 Heart Failure 23302636 I50 D006331 HP:0001635 MicroRNA 210 as a Biomarker for Congestive Heart Failure other hsa-mir-210 Heart Failure 28249798 I50 D006331 HP:0001635 Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis. other hsa-mir-212 Heart Failure 21977024 I50 D006331 HP:0001635 Conversely, alcohol-mediated inhibition of mTOR/S6K1, down-regulation of INS receptor and growth-inhibitory mir-200 family, and upregulation of mir-212 that promotes fetal gene program may exacerbate CRS-related cardiomyopathy. other hsa-mir-214 Heart Failure 29584819 I50 D006331 HP:0001635 ROCR acted as a microRNA-214 sponge to release PTEN, which blocked activation of the PI3 kinase/Akt pathway to inhibit cardiomyocyte proliferation and ROCR may be a novel therapeutic target for preventing and treating heart failure other hsa-mir-22 Heart Failure 22570371 I50 D006331 HP:0001635 These data indicate that miR-22 functions as an integrator of Ca(2+) homeostasis and myofibrillar protein content during stress in the heart and shed light on the mechanisms that enhance propensity toward heart failure. other hsa-mir-22 Heart Failure 27687198 I50 D006331 HP:0001635 Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. other hsa-mir-23a Heart Failure 25829494 I50 D006331 HP:0001635 Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression. other hsa-mir-25 Heart Failure 24161931 I50 D006331 HP:0001635 Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. other hsa-mir-25 Heart Failure 25214573 I50 D006331 HP:0001635 miR-25 in heart failure. other hsa-mir-29 Heart Failure 19320780 I50 D006331 HP:0001635 The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy. other hsa-mir-29a Heart Failure 25464262 I50 D006331 HP:0001635 MicroRNA-29a (miR-29a), a key regulator of tissue fibrosis, was highly expressed in the exosomes and the marginal area of the RIC group. other hsa-mir-30a Heart Failure 19096030 I50 D006331 HP:0001635 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-30b Heart Failure 19096030 I50 D006331 HP:0001635 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling other hsa-mir-30b Heart Failure 25301066 I50 D006331 HP:0001635 E2F1 transcriptionally represses miR-30b expression. other hsa-mir-30d Heart Failure 26858295 I50 D006331 HP:0001635 Letter by Sardu et al Regarding Article, Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. other hsa-mir-30d Heart Failure 26858296 I50 D006331 HP:0001635 Response to Letter Regarding Article, Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. other hsa-mir-34a Heart Failure 24714087 I50 D006331 HP:0001635 These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure. other hsa-mir-378 Heart Failure 27742689 I50 D006331 HP:0001635 Role of microRNA in metabolic shift during heart failure. other hsa-mir-423 Heart Failure 24506564 I50 D006331 HP:0001635 The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis. other hsa-mir-451a Heart Failure 25763857 I50 D006331 HP:0001635 Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells. other hsa-mir-499 Heart Failure 22110643 I50 D006331 HP:0001635 We conclude that miR-1 and -499 play differential roles in cardiac differentiation of hESCs in a context-dependent fashion. While miR-499 promotes ventricular specification of hESCs, miR-1 serves to facilitate electrophysiological maturation. other hsa-mir-499 Heart Failure 22752967 I50 D006331 HP:0001635 miR-499 is increased in human and murine cardiac hypertrophy and cardiomyopathy, is sufficient to cause murine heart failure, and accelerates maladaptation to pressure overloading. other hsa-mir-508 Heart Failure 23465244 I50 D006331 HP:0001635 Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients other hsa-mir-665 Heart Failure 25111814 I50 D006331 HP:0001635 MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure. other hsa-mir-92 Heart Failure 18582896 I50 D006331 HP:0001635 To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes. other hsa-mir-99 Heart Failure 25517466 I50 D006331 HP:0001635 concept for identifying and activating conserved molecular programs to regenerate the damaged heart. other hsa-mir-15a Heart Valve Disease 28888871 cardiovascular system disease DOID:4079 I39 D006349 Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. other hsa-mir-29a Heart Valve Disease 28888871 cardiovascular system disease DOID:4079 I39 D006349 Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. other hsa-mir-106a Helicobacter pylori Infection 25307786 B96.81 D016480 600263 HP:0005202 A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. other hsa-mir-155 Helicobacter pylori Infection 26191144 B96.81 D016480 600263 HP:0005202 Inflammatory response of macrophages cultured with Helicobacter pylori strains was regulated by miR-155. other hsa-mir-375 Helicobacter pylori Infection 25307786 B96.81 D016480 600263 HP:0005202 A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. other hsa-mir-126 Hemangioma 28538565 disease of cellular proliferation DOID:255 D18.0 D006391 602089 Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation. other hsa-mir-382 Hemangioma 28112362 disease of cellular proliferation DOID:255 D18.0 D006391 602089 Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway. other hsa-let-7 Hematologic Neoplasms 26676759 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Taken together, our results reveal a previously unknown mechanism by which Myc induces apoptosis independent of the p53 pathway and as a response to HDACi in malignant hematopoietic cells. other hsa-mir-103 Hematologic Neoplasms 24921248 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. other hsa-mir-124 Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-125b Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-15 Hematologic Neoplasms 26676759 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Taken together, our results reveal a previously unknown mechanism by which Myc induces apoptosis independent of the p53 pathway and as a response to HDACi in malignant hematopoietic cells. other hsa-mir-155 Hematologic Neoplasms 23815946 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Relationship between microRNA-155 and hematological malignancies other hsa-mir-155 Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-155 Hematologic Neoplasms 23538486 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Transfection of Kasumi-1 cells with a new type of polymer carriers loaded with miR-155 and antago-miR-155. other hsa-mir-181a Hematologic Neoplasms 16249029 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 The stress-induced modulation of hematopoietic miR-181a levels through AChE, PKC and PKA cascade(s) suggests using miRNA mimics for diverting the fate of hematopoietic tumor cells towards differentiation and/or apoptosis. other hsa-mir-21 Hematologic Neoplasms 24921248 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. other hsa-mir-223 Hematologic Neoplasms 25753223 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 C/EBP伪 interacts with AP-1 proteins to bind hybrid DNA elements during monopoiesis, and induction of Gfi-1, C/EBP蔚, KLF5, and miR-223 by C/EBP伪 enables granulopoiesis. other hsa-mir-23b Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-26a Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-29b Hematologic Neoplasms 25004911 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. other hsa-mir-31 Hematologic Neoplasms 24921248 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. other hsa-mir-378 Hematologic Neoplasms 27864740 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. other hsa-mir-566 Hematologic Neoplasms 24921248 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. other hsa-mir-93 Hematologic Neoplasms 24921248 disease of cellular proliferation DOID:2531 C96.9 D019337 HP:0004377 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. other hsa-let-7 Hemoglobin Diseases 27861570 D58.2 D006450 141900 HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts. other hsa-mir-1246 Hemophilia A 26176629 D66 D006467 306700 Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene. other hsa-mir-122 Hepatitis [unspecific] 25973575 endocrine system disease DOID:2237 D006521 HP:0012115 These results demonstrate that first, exosomes mediate communication between hepatocytes and monocytes/macrophages and second, hepatocyte-derived miRNA-122 can reprogram monocytes inducing sensitization to LPS. other hsa-mir-208b Hepatitis [unspecific] 27841874 endocrine system disease DOID:2237 D006521 HP:0012115 Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. other hsa-mir-223 Hepatitis [unspecific] 29145157 endocrine system disease DOID:2237 D006521 HP:0012115 BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis other hsa-mir-499a Hepatitis [unspecific] 27841874 endocrine system disease DOID:2237 D006521 HP:0012115 Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. other hsa-mir-101-1 Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-101-2 Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-106a Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-106b Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-106b Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-1-1 Hepatitis B Virus Infection 21520166 disease by infectious agent DOID:2043 B16/18 D006509 610424 MiR-1 regulates the expression of several host genes to enhance HBV replication and reverse cancer cell phenotype, which is apparently beneficial for HBV replication. other hsa-mir-1-2 Hepatitis B Virus Infection 21520166 disease by infectious agent DOID:2043 B16/18 D006509 610424 MiR-1 regulates the expression of several host genes to enhance HBV replication and reverse cancer cell phenotype, which is apparently beneficial for HBV replication. other hsa-mir-122 Hepatitis B Virus Infection 26541590 disease by infectious agent DOID:2043 B16/18 D006509 610424 Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122. other hsa-mir-122 Hepatitis B Virus Infection 23508904 disease by infectious agent DOID:2043 B16/18 D006509 610424 Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B other hsa-mir-122 Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-122 Hepatitis B Virus Infection 21902631 disease by infectious agent DOID:2043 B16/18 D006509 610424 Hybridization between the host-encoded, liver-specific microRNA (miR-122) and the 5'-untranslated region of HCV genome was shown to be required for effective viral RNA replication. other hsa-mir-122 Hepatitis B Virus Infection 21903935 disease by infectious agent DOID:2043 B16/18 D006509 610424 miR-122 may down-regulate HBV replication by binding to the viral target sequence, contributing to the persistent/chronic infection of HBV, and that HBV-induced modulation of miR-122 expression may represent a mechanism to facilitate viral pathogenesis. other hsa-mir-122 Hepatitis B Virus Infection 23055569 disease by infectious agent DOID:2043 B16/18 D006509 610424 Inhibition of Alpha Interferon (IFN-alpha)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-ж┿ other hsa-mir-122 Hepatitis B Virus Infection 24314655 disease by infectious agent DOID:2043 B16/18 D006509 610424 microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture. other hsa-mir-122 Hepatitis B Virus Infection 25299106 disease by infectious agent DOID:2043 B16/18 D006509 610424 Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease. other hsa-mir-125a Hepatitis B Virus Infection 24824183 disease by infectious agent DOID:2043 B16/18 D006509 610424 Functional interplay between hepatitis B virus X protein and human miR-125a in HBV infection. other hsa-mir-125a Hepatitis B Virus Infection 21317190 disease by infectious agent DOID:2043 B16/18 D006509 610424 hsa-mir-125a-5p, was found to interact with the viral sequence and to suppress the reporter activity markedly. other hsa-mir-151a Hepatitis B Virus Infection 26801621 disease by infectious agent DOID:2043 B16/18 D006509 610424 We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model. other hsa-mir-181b Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-185 Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-18a Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-18a Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-18b Hepatitis B Virus Infection 21876625 disease by infectious agent DOID:2043 B16/18 D006509 610424 potential associated miRNA other hsa-mir-197 Hepatitis B Virus Infection 23710316 disease by infectious agent DOID:2043 B16/18 D006509 610424 miR-197 Expression in Peripheral Blood Mononuclear Cells from Hepatitis B Virus-Infected Patients. other hsa-mir-21 Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-215 Hepatitis B Virus Infection 24434140 disease by infectious agent DOID:2043 B16/18 D006509 610424 Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. other hsa-mir-22 Hepatitis B Virus Infection 23508904 disease by infectious agent DOID:2043 B16/18 D006509 610424 Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B other hsa-mir-24 Hepatitis B Virus Infection 26801621 disease by infectious agent DOID:2043 B16/18 D006509 610424 We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model. other hsa-mir-29 Hepatitis B Virus Infection 25299106 disease by infectious agent DOID:2043 B16/18 D006509 610424 Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease. other hsa-mir-29a Hepatitis B Virus Infection 23285022 disease by infectious agent DOID:2043 B16/18 D006509 610424 MicroRNA-29a-5p Is a Novel Predictor for Early Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma after Surgical Resection other hsa-mir-29c Hepatitis B Virus Infection 26456479 disease by infectious agent DOID:2043 B16/18 D006509 610424 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-31 Hepatitis B Virus Infection 24824126 disease by infectious agent DOID:2043 B16/18 D006509 610424 HBsAg regulation of miR-31 expression in HepG2 cells other hsa-mir-323b Hepatitis B Virus Infection 24341744 disease by infectious agent DOID:2043 B16/18 D006509 610424 Association of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication. other hsa-mir-323b Hepatitis B Virus Infection 26037063 disease by infectious agent DOID:2043 B16/18 D006509 610424 The association between microRNA-323b polymorphism and hepatitis B virus persistent infection - some problems should be addressed. other hsa-mir-323b Hepatitis B Virus Infection 26037064 disease by infectious agent DOID:2043 B16/18 D006509 610424 The association between microRNA-323b polymorphism and hepatitis B virus persistent infection - some problems should be addressed. other hsa-mir-338 Hepatitis B Virus Infection 22912826 disease by infectious agent DOID:2043 B16/18 D006509 610424 The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation. other hsa-mir-425 Hepatitis B Virus Infection 26801621 disease by infectious agent DOID:2043 B16/18 D006509 610424 We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model. other hsa-mir-5193 Hepatitis B Virus Infection 26456535 disease by infectious agent DOID:2043 B16/18 D006509 610424 Therefore, miR-5193 might be useful and have a vital role for inhibition of HBV replication in the future. other hsa-mir-520b Hepatitis B Virus Infection 24886421 disease by infectious agent DOID:2043 B16/18 D006509 610424 HBx accelerates hepatocarcinogenesis with partner survivin through modulating tumor suppressor miR-520b and oncoprotein HBXIP. other hsa-mir-99 Hepatitis B Virus Infection 27886437 disease by infectious agent DOID:2043 B16/18 D006509 610424 The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy. other hsa-let-7b Hepatitis C Virus Infection 22391672 disease by infectious agent DOID:1883 B19.2 D006526 609532 Let-7b is a novel regulator of hepatitis C virus replication. other hsa-let-7f Hepatitis C Virus Infection 27496568 disease by infectious agent DOID:1883 B19.2 D006526 609532 these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication. other hsa-mir-1181 Hepatitis C Virus Infection 20006370 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation other hsa-mir-122 Hepatitis C Virus Infection 23537271 disease by infectious agent DOID:1883 B19.2 D006526 609532 Down-regulating miR-122 expression by HCV core protein may give a new insight into the interaction between HCV and miR-122 and chronic HCV infection other hsa-mir-122 Hepatitis C Virus Infection 25646812 disease by infectious agent DOID:1883 B19.2 D006526 609532 Circulating miRNA-122 levels are associated with hepatic necroinflammation and portal hypertension in HIV/HCV coinfection. other hsa-mir-122 Hepatitis C Virus Infection 16141076 disease by infectious agent DOID:1883 B19.2 D006526 609532 interaction with non-coding regions of Hepatitis C help its replication other hsa-mir-122 Hepatitis C Virus Infection 18550664 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122: Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells other hsa-mir-122 Hepatitis C Virus Infection 19020517 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122: microRNA-122 stimulates translation of hepatitis C virus RNA other hsa-mir-122 Hepatitis C Virus Infection 19122656 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122: Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy other hsa-mir-122 Hepatitis C Virus Infection 20371461 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122, a major regulatory RNA in liver that fine-tunes the expression of over 100 cellular genes and enhances HCV replication other hsa-mir-122 Hepatitis C Virus Infection 20527935 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122:Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma other hsa-mir-122 Hepatitis C Virus Infection 21653556 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. other hsa-mir-122 Hepatitis C Virus Infection 22189820 disease by infectious agent DOID:1883 B19.2 D006526 609532 Here we show that HCV IRES-dependent translation efficiency in the hepatoma cell line Huh7 is highest during the G 0 and G 1 phases of the cell cycle but significantly drops during the S phase and even more in the G 2/M phase. The superimposed stimulation of HCV translation by ectopic miR-122 works best during the G 0, G 1 and G 2/M phases but is lower during the S phase. However, the levels of Ago2 protein do not substantially change during cell cycle phases, indicating that other cellular factors involved in HCV translation stimulation by miR-122 may be differentially expressed in different cell cycle phases. Moreover, the levels of endogenously expressed miR-122 in Huh7 cells are lowest in the S phase, indicating that the predominant G 0/G 1 state of non-dividing hepatocytes in the liver facilitates high expression of the HCV genome and stimulation by miR-122, with yet unknown factors involved in the differential extent of stimulation by miR-122. other hsa-mir-122 Hepatitis C Virus Infection 22342424 disease by infectious agent DOID:1883 B19.2 D006526 609532 Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. other hsa-mir-122 Hepatitis C Virus Infection 22593164 disease by infectious agent DOID:1883 B19.2 D006526 609532 Expression of MicroRNA miR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus. other hsa-mir-122 Hepatitis C Virus Infection 23126531 disease by infectious agent DOID:1883 B19.2 D006526 609532 Alcohol Facilitates HCV RNA Replication Via Up-Regulation of miR-122 Expression and Inhibition of Cyclin G1 in Human Hepatoma Cells other hsa-mir-122 Hepatitis C Virus Infection 23218444 disease by infectious agent DOID:1883 B19.2 D006526 609532 Can tobacco use promote HCV-induced miR-122 hijacking and hepatocarcinogenesis other hsa-mir-122 Hepatitis C Virus Infection 23245472 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-122-dependent and -independent replication of Hepatitis C Virus in Hep3B human hepatoma cells other hsa-mir-122 Hepatitis C Virus Infection 23248316 disease by infectious agent DOID:1883 B19.2 D006526 609532 Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication other hsa-mir-122 Hepatitis C Virus Infection 23405269 disease by infectious agent DOID:1883 B19.2 D006526 609532 microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation other hsa-mir-122 Hepatitis C Virus Infection 23770926 disease by infectious agent DOID:1883 B19.2 D006526 609532 mir-122 and the Hepatitis C RNA genome: more than just stability. other hsa-mir-122 Hepatitis C Virus Infection 23793894 disease by infectious agent DOID:1883 B19.2 D006526 609532 A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes. other hsa-mir-122 Hepatitis C Virus Infection 24141094 disease by infectious agent DOID:1883 B19.2 D006526 609532 The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122. other hsa-mir-122 Hepatitis C Virus Infection 24106328 disease by infectious agent DOID:1883 B19.2 D006526 609532 By use of duplex and precursor miR-122 mimetic molecules that carried mutations in the passenger strand of miR-122, the effects on viral and reporter gene expression could be pinpointed to the action of precursor miR-122 molecules. other hsa-mir-122 Hepatitis C Virus Infection 25836383 disease by infectious agent DOID:1883 B19.2 D006526 609532 The binding of p68 onto HCV RNA can be specifically inhibited by miR-122 via a competitive binding process. other hsa-mir-122 Hepatitis C Virus Infection 23881584 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122 promotion of the hepatitis C virus life cycle: sound in the silence. other hsa-mir-122 Hepatitis C Virus Infection 24721497 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C virus and human miR-122: insights from the bench to the clinic. other hsa-mir-122 Hepatitis C Virus Infection 24844965 disease by infectious agent DOID:1883 B19.2 D006526 609532 Different types of IFN increase the expression of miRNAs that inhibit HCV replication and decrease the expression of miRNA-122 that supports HCV replication. Thus the regulation of HCV replication-related miRNA expression is a general anti-HCV mechanism by different types of IFN. However, the regulation pattern by type II IFN is different from those by other types of IFNs,implying that type II IFN has different anti-HCV mechanisms from other types of IFN at miRNA level. other hsa-mir-122 Hepatitis C Virus Infection 25403145 disease by infectious agent DOID:1883 B19.2 D006526 609532 Our study provides insight into the interaction between miR-122 and HCV, including viral adaptation to reduced miR-122 bioavailability, and has implications for the development of anti-miR-122-based HCV drugs. other hsa-mir-122 Hepatitis C Virus Infection 25662750 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation. other hsa-mir-122 Hepatitis C Virus Infection 25768906 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C virus RNA functionally sequesters miR-122. other hsa-mir-122 Hepatitis C Virus Infection 25855736 disease by infectious agent DOID:1883 B19.2 D006526 609532 Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5' Untranslated Region. other hsa-mir-122 Hepatitis C Virus Infection 26096908 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C virus addiction to liver miR-122 takes its Toll on the host. other hsa-mir-122 Hepatitis C Virus Infection 23826300 disease by infectious agent DOID:1883 B19.2 D006526 609532 Modulation of hepatitis C virus RNA accumulation and translation by DDX6 and miR-122 are mediated by separate mechanisms. other hsa-mir-122 Hepatitis C Virus Infection 25963774 disease by infectious agent DOID:1883 B19.2 D006526 609532 The mechanism of HCV dyslipidemia is complex and could partly relate to the effect of miR-122 on lipid metabolism which requires further evaluation in a larger study. other hsa-mir-122 Hepatitis C Virus Infection 26330540 disease by infectious agent DOID:1883 B19.2 D006526 609532 These results show that hnRNP K is a cellular protein that binds and affects the accumulation of miR-122. Its ability to also bind HCV RNA near the miR-122 binding site suggests a role for miR-122 recognition of HCV RNA. other hsa-mir-122 Hepatitis C Virus Infection 26305877 disease by infectious agent DOID:1883 B19.2 D006526 609532 Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect. other hsa-mir-122 Hepatitis C Virus Infection 19965718 disease by infectious agent DOID:1883 B19.2 D006526 609532 a locked nucleic acid (LNA)-modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia other hsa-mir-122 Hepatitis C Virus Infection 26845923 disease by infectious agent DOID:1883 B19.2 D006526 609532 Mechanism of regulation of HCV replication by miR-122. other hsa-mir-122 Hepatitis C Virus Infection 22965312 disease by infectious agent DOID:1883 B19.2 D006526 609532 these findings indicate that miR-122 and functional lipid metabolism are involved in the tissue tropism of HCV infection. In this review, we would like to focus on the role of miR-122 and lipid metabolism in the cell tropism of HCV. other hsa-mir-122 Hepatitis C Virus Infection 29549787 disease by infectious agent DOID:1883 B19.2 D006526 609532 Identification of nucleotides in the 5'UTR and amino acids substitutions that are essential for the infectivity of 5'UTR-NS5A recombinant of hepatitis C virus genotype 1b (strain Con1). other hsa-mir-122 Hepatitis C Virus Infection 24871972 disease by infectious agent DOID:1883 B19.2 D006526 609532 Representatively, miR-122 directly modulates the HCV life cycle by increasing HCV translation and genomic RNA stability. other hsa-mir-122 Hepatitis C Virus Infection 25275643 disease by infectious agent DOID:1883 B19.2 D006526 609532 Exosome-loading with a miR-122 inhibitor, or inhibition of HSP90, vacuolar H+-ATPases, and proton pumps, significantly suppressed exosome-mediated HCV transmission to na茂ve cells. other hsa-mir-122 Hepatitis C Virus Infection 26587035 disease by infectious agent DOID:1883 B19.2 D006526 609532 characteristics of the miR-122 and Let-7 families further highlight the suitability of tree shrew as the animal model in HCV research. other hsa-mir-122 Hepatitis C Virus Infection 26927063 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV) transcripts other hsa-mir-122 Hepatitis C Virus Infection 27303683 disease by infectious agent DOID:1883 B19.2 D006526 609532 HCV infection requires miR-122 other hsa-mir-122 Hepatitis C Virus Infection 27366906 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2. other hsa-mir-122 Hepatitis C Virus Infection 27440892 disease by infectious agent DOID:1883 B19.2 D006526 609532 the expression of CAMP in nonhepatic 293T cells expressing claudin 1 and microRNA miR-122 confers complete propagation of HCV. other hsa-mir-122 Hepatitis C Virus Infection 27578438 disease by infectious agent DOID:1883 B19.2 D006526 609532 Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122. other hsa-mir-122 Hepatitis C Virus Infection 27641985 disease by infectious agent DOID:1883 B19.2 D006526 609532 The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control. other hsa-mir-122 Hepatitis C Virus Infection 27692039 disease by infectious agent DOID:1883 B19.2 D006526 609532 Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family. other hsa-mir-122 Hepatitis C Virus Infection 28475652 disease by infectious agent DOID:1883 B19.2 D006526 609532 Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis. other hsa-mir-122 Hepatitis C Virus Infection 29411512 disease by infectious agent DOID:1883 B19.2 D006526 609532 This result along with the idea about the driver function of circulating miRNAs will promote further investigations that eventually lead to the development of novel strategies to treat HCV infection-associated extrahepatic comorbidities other hsa-mir-122 Hepatitis C Virus Infection 29528577 disease by infectious agent DOID:1883 B19.2 D006526 609532 microRNA-122 is a potential marker of progression of hepatocytes injury in patients infected with HCV but not a reliable marker for diagnosis of HCC other hsa-mir-130a Hepatitis C Virus Infection 24383925 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-130a inhibits HCV replication by restoring the innate immune response. other hsa-mir-130a Hepatitis C Virus Infection 26060358 disease by infectious agent DOID:1883 B19.2 D006526 609532 Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. other hsa-mir-130a Hepatitis C Virus Infection 29321333 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. other hsa-mir-142 Hepatitis C Virus Infection 21970718 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-128a, miR-196a and miR-142-3p were modulated in a concerted fashion in all three HCV clones other hsa-mir-143 Hepatitis C Virus Infection 17188425 disease by infectious agent DOID:1883 B19.2 D006526 609532 miRNA-143 and -145 levels increase as disease progresses from chronic hepatitis to cirrhosis, suggesting that they may turn on inflammatory or fibrosis related genes and/or turn off tumor suppressor genes. other hsa-mir-145 Hepatitis C Virus Infection 17188425 disease by infectious agent DOID:1883 B19.2 D006526 609532 miRNA-143 and -145 levels increase as disease progresses from chronic hepatitis to cirrhosis, suggesting that they may turn on inflammatory or fibrosis related genes and/or turn off tumor suppressor genes. other hsa-mir-145 Hepatitis C Virus Infection 27496568 disease by infectious agent DOID:1883 B19.2 D006526 609532 these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication. other hsa-mir-148a Hepatitis C Virus Infection 27591428 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models. other hsa-mir-149 Hepatitis C Virus Infection 20006370 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation other hsa-mir-155 Hepatitis C Virus Infection 24383923 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver. other hsa-mir-155 Hepatitis C Virus Infection 24591085 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection other hsa-mir-17 Hepatitis C Virus Infection 25707620 disease by infectious agent DOID:1883 B19.2 D006526 609532 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. other hsa-mir-196a-1 Hepatitis C Virus Infection 21970718 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-128a, miR-196a and miR-142-3p were modulated in a concerted fashion in all three HCV clones other hsa-mir-196b Hepatitis C Virus Infection 24591085 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection other hsa-mir-199a Hepatitis C Virus Infection 27496568 disease by infectious agent DOID:1883 B19.2 D006526 609532 these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication. other hsa-mir-199a-1 Hepatitis C Virus Infection 19144437 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-199a: Regulation of the hepatitis C virus genome replication other hsa-mir-199a-2 Hepatitis C Virus Infection 19144437 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-199a: Regulation of the hepatitis C virus genome replication other hsa-mir-19a Hepatitis C Virus Infection 28077652 disease by infectious agent DOID:1883 B19.2 D006526 609532 Furthermore, we demonstrate the role of exosomal miR-19a in activation of the STAT3-TGF-β pathway in HSC other hsa-mir-221 Hepatitis C Virus Infection 26090579 disease by infectious agent DOID:1883 B19.2 D006526 609532 IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment. other hsa-mir-221 Hepatitis C Virus Infection 27496568 disease by infectious agent DOID:1883 B19.2 D006526 609532 these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication. other hsa-mir-23a Hepatitis C Virus Infection 19578061 disease by infectious agent DOID:1883 B19.2 D006526 609532 virus specific, miR-122-sensitive double-helical switch element in the 5' region--a new mechanism of action of micro-RNAs other hsa-mir-24-1 Hepatitis C Virus Infection 20006370 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation other hsa-mir-24-2 Hepatitis C Virus Infection 20006370 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation other hsa-mir-27a Hepatitis C Virus Infection 24824429 disease by infectious agent DOID:1883 B19.2 D006526 609532 MicroRNA-27a modulates HCV infection in differentiated hepatocyte-like cells from adipose tissue-derived mesenchymal stem cells. other hsa-mir-27b Hepatitis C Virus Infection 27665576 disease by infectious agent DOID:1883 B19.2 D006526 609532 Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. other hsa-mir-29a Hepatitis C Virus Infection 26429314 disease by infectious agent DOID:1883 B19.2 D006526 609532 This study showed that HCV infection might abrogate NK cytotoxic potential through altering PU.1, NKG2D receptor and perforin molecules. other hsa-mir-29a Hepatitis C Virus Infection 21606534 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. other hsa-mir-29b-1 Hepatitis C Virus Infection 21606534 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. other hsa-mir-29b-2 Hepatitis C Virus Infection 21606534 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. other hsa-mir-29c Hepatitis C Virus Infection 21606534 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. other hsa-mir-449a Hepatitis C Virus Infection 23226395 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Mediated Changes in miRNA-449a Modulates Inflammatory Biomarker YKL40 through Components of the NOTCH Signaling Pathway other hsa-mir-503 Hepatitis C Virus Infection 28343379 disease by infectious agent DOID:1883 B19.2 D006526 609532 Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-κb/miR-503/bcl-2 Pathway. other hsa-mir-557 Hepatitis C Virus Infection 25707620 disease by infectious agent DOID:1883 B19.2 D006526 609532 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. other hsa-mir-638 Hepatitis C Virus Infection 20006370 disease by infectious agent DOID:1883 B19.2 D006526 609532 miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation other hsa-mir-765 Hepatitis C Virus Infection 25707620 disease by infectious agent DOID:1883 B19.2 D006526 609532 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. other hsa-mir-122 Hepatitis E Virus Infection 29540601 disease by infectious agent DOID:4411 B17.2 D016751 Positive regulation of hepatitis E virus replication by microRNA-122 other hsa-mir-221 Hepatitis E Virus Infection 23579640 disease by infectious agent DOID:4411 B17.2 D016751 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells other hsa-mir-222 Hepatitis E Virus Infection 23579640 disease by infectious agent DOID:4411 B17.2 D016751 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells other hsa-mir-184 Hepatoblastoma 26081234 disease of cellular proliferation DOID:687 C22.2 D018197 HP:0002884 miRNA-184 lentivirus-mediated human lens epithelial cells (HLEC) can inhibit the occurrence of epithelial-mesenchymal transition (EMT). other hsa-mir-199a Hepatoblastoma 25673149 disease of cellular proliferation DOID:687 C22.2 D018197 HP:0002884 The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. other hsa-mir-34a Hepatoblastoma 28277300 disease of cellular proliferation DOID:687 C22.2 D018197 HP:0002884 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. other hsa-mir-34b Hepatoblastoma 28277300 disease of cellular proliferation DOID:687 C22.2 D018197 HP:0002884 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. other hsa-mir-34c Hepatoblastoma 28277300 disease of cellular proliferation DOID:687 C22.2 D018197 HP:0002884 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. other hsa-mir-15a Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-16 Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-15b Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-195 Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-29a Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-29b Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-29c Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-30a Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-30b Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-30c Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-30d Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-30e Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-200a Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-200b Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-200c Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-141 Hereditary Breast Carcinoma 24104964 D05 D001943 114480 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. other hsa-mir-218-1 Hirschsprung Disease 25786906 gastrointestinal system disease DOID:10487 Q43.1 D006627 600156 HP:0002251 SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. other hsa-mir-34a Holt-Oram Syndrome 27471727 genetic disease DOID:0060468 Q87.2 C535326 142900 This approach allowed to discover complex regulatory circuits involving novel miRNAs and protein coding genes not considered before in the HOS such as miR-34a and miR-30 and their targets. other hsa-mir-155 Human Cytomegalovirus Infection 28642130 B25 D003586 609889 mir-155 expression is downregulated in kidney transplant patients with human cytomegalovirus infection. other hsa-mir-21 Human Cytomegalovirus Infection 28589873 B25 D003586 609889 Human cytomegalovirus microRNAs are carried by virions and dense bodies and are delivered to target cells. other hsa-mir-218 Human Cytomegalovirus Infection 28589873 B25 D003586 609889 Human cytomegalovirus microRNAs are carried by virions and dense bodies and are delivered to target cells. other hsa-let-7c Human Immunodeficiency Virus Infection 25717002 B20 D015658 609423 Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process. other hsa-mir-101-1 Human Immunodeficiency Virus Infection 23554480 B20 D015658 609423 HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells other hsa-mir-101-2 Human Immunodeficiency Virus Infection 23554480 B20 D015658 609423 HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells other hsa-mir-124a Human Immunodeficiency Virus Infection 25717002 B20 D015658 609423 Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process. other hsa-mir-125b Human Immunodeficiency Virus Infection 24434277 B20 D015658 609423 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. other hsa-mir-125b Human Immunodeficiency Virus Infection 22527633 B20 D015658 609423 Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection. other hsa-mir-125b-1 Human Immunodeficiency Virus Infection 23251514 B20 D015658 609423 Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b other hsa-mir-125b-2 Human Immunodeficiency Virus Infection 23251514 B20 D015658 609423 Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b other hsa-mir-126 Human Immunodeficiency Virus Infection 28250134 B20 D015658 609423 MicroRNA miR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection. other hsa-mir-1290 Human Immunodeficiency Virus Infection 26469550 B20 D015658 609423 Our study emphasizes the role of cellular miRNAs in HIV-1 latency regulation, and it suggests that inhibitors of miR-196b and miR-1290 could be used to activate latent HIV-1. other hsa-mir-132 Human Immunodeficiency Virus Infection 23357732 B20 D015658 609423 miR-132 enhances HIV-1 replication other hsa-mir-150 Human Immunodeficiency Virus Infection 24434277 B20 D015658 609423 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. other hsa-mir-150 Human Immunodeficiency Virus Infection 22527633 B20 D015658 609423 Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection. other hsa-mir-150 Human Immunodeficiency Virus Infection 23094138 B20 D015658 609423 Here, we observed that the expression levels of the cellular factors Trim5α, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-α and IFN-β in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells. other hsa-mir-155 Human Immunodeficiency Virus Infection 25873391 B20 D015658 609423 we demonstrate that TRIM32, an E3 ubiquitin ligase, promotes reactivation from latency by directly modifying IκBα, leading to a novel mechanism of NF-κB induction not involving IκB kinase activation. other hsa-mir-155 Human Immunodeficiency Virus Infection 24391808 B20 D015658 609423 Cocaine enhances HIV-1 infectivity in monocyte derived dendritic cells by suppressing microRNA-155. other hsa-mir-155 Human Immunodeficiency Virus Infection 26181817 B20 D015658 609423 Levels of miR-155 and miR-223 but not miR-92 were strongly correlated negatively with EV abundance and size in ART-naive patients. other hsa-mir-155 Human Immunodeficiency Virus Infection 27981723 B20 D015658 609423 MicroRNA-155 is a biomarker of T-cell activation and immune dysfunction in HIV-1-infected patients. other hsa-mir-196a Human Immunodeficiency Virus Infection 24872081 B20 D015658 609423 Involvement of miR-196a in HIV-associated neurocognitive disorders. other hsa-mir-196b Human Immunodeficiency Virus Infection 26469550 B20 D015658 609423 Our study emphasizes the role of cellular miRNAs in HIV-1 latency regulation, and it suggests that inhibitors of miR-196b and miR-1290 could be used to activate latent HIV-1. other hsa-mir-21 Human Immunodeficiency Virus Infection 24961346 B20 D015658 609423 Relevance of miR-21 in HIV and non-HIV-related lymphomas. other hsa-mir-21 Human Immunodeficiency Virus Infection 26473639 B20 D015658 609423 These data reveal specific regulation of plasma miR-21 in HIV,HIV/HCV coinfection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection. other hsa-mir-221 Human Immunodeficiency Virus Infection 23555914 B20 D015658 609423 HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy other hsa-mir-222 Human Immunodeficiency Virus Infection 23555914 B20 D015658 609423 HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy other hsa-mir-223 Human Immunodeficiency Virus Infection 26181817 B20 D015658 609423 Levels of miR-155 and miR-223 but not miR-92 were strongly correlated negatively with EV abundance and size in ART-naive patients. other hsa-mir-223 Human Immunodeficiency Virus Infection 22527633 B20 D015658 609423 Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection. other hsa-mir-223 Human Immunodeficiency Virus Infection 23094138 B20 D015658 609423 Here, we observed that the expression levels of the cellular factors Trim5α, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-α and IFN-β in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells. other hsa-mir-28 Human Immunodeficiency Virus Infection 24434277 B20 D015658 609423 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. other hsa-mir-28 Human Immunodeficiency Virus Infection 22527633 B20 D015658 609423 Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection. other hsa-mir-28 Human Immunodeficiency Virus Infection 23094138 B20 D015658 609423 Here, we observed that the expression levels of the cellular factors Trim5α, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-α and IFN-β in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells. other hsa-mir-29 Human Immunodeficiency Virus Infection 25808800 B20 D015658 609423 The miRNA-29 family could influence the clinical progression of HIV-1 infection, the HIV-1 proviral load and the innate immune response against HIV-1. other hsa-mir-29a Human Immunodeficiency Virus Infection 25486977 B20 D015658 609423 links miR-29a to viral latency and suggests another approach to activate and destroy latent HIV-1 reservoirs. other hsa-mir-29a Human Immunodeficiency Virus Infection 24103357 B20 D015658 609423 The lack of significant negative correlation of miR-29a and TTP expression levels suggests that while miR-29a may contribute to TTP regulation, additional factors are involved. Reduced TTP expression during acute infection is consistent with increased cytokine production during this phase of infection, but the increases in TTP observed during late-stage infection were insufficient to halt runaway cytokine levels. other hsa-mir-34a Human Immunodeficiency Virus Infection 25717002 B20 D015658 609423 Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process. other hsa-mir-34c Human Immunodeficiency Virus Infection 27993935 B20 D015658 609423 miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication. other hsa-mir-382 Human Immunodeficiency Virus Infection 22527633 B20 D015658 609423 Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection. other hsa-mir-382 Human Immunodeficiency Virus Infection 23094138 B20 D015658 609423 Here, we observed that the expression levels of the cellular factors Trim5α, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-α and IFN-β in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells. other hsa-mir-500 Human Immunodeficiency Virus Infection 28594894 B20 D015658 609423 MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology. other hsa-mir-9 Human Immunodeficiency Virus Infection 29497921 B20 D015658 609423 Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration other hsa-mir-9-1 Human Immunodeficiency Virus Infection 23129528 B20 D015658 609423 The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection other hsa-mir-9-1 Human Immunodeficiency Virus Infection 23508624 B20 D015658 609423 Modulation of BK Channel by MicroRNA-9 in Neurons After Exposure to HIV and Methamphetamine other hsa-mir-9-2 Human Immunodeficiency Virus Infection 23129528 B20 D015658 609423 The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection other hsa-mir-93 Human Immunodeficiency Virus Infection 28594894 B20 D015658 609423 MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology. other hsa-let-7a Human Papilloma Virus Infection 21442230 B97.7 D027383 HPV-38 was predicted to express an miRNA conserved to human let-7a and the expression of let-7a, in HPV-38-positive non-melanoma skin cancer (NMSC) biopsies was 10-fold higher than those with HPV-positive (for other types except HPV-38) and HPV-negative NMSCs, suggesting that let-7a expression might be related to HPV-38 infection. other hsa-mir-125b Human Papilloma Virus Infection 26180794 B97.7 D027383 miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. other hsa-mir-146a Human Papilloma Virus Infection 28551628 B97.7 D027383 Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. other hsa-mir-146a Human Papilloma Virus Infection 29181576 B97.7 D027383 HPV16 induces the overexpression of miR-146a in the initial stages of carcinogenesis (hyperplasia and dysplasia), whereas decreases its expression at later stages (CIS) other hsa-mir-150 Human Papilloma Virus Infection 28551628 B97.7 D027383 Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. other hsa-mir-205 Human Papilloma Virus Infection 24314651 B97.7 D027383 miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. other hsa-mir-24 Human Papilloma Virus Infection 24314651 B97.7 D027383 miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. other hsa-mir-34a Human Papilloma Virus Infection 26180794 B97.7 D027383 miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. other hsa-mir-137 Huntington Disease 23965969 nervous system disease DOID:12858 G10 D006816 143100 Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs. other hsa-mir-137 Huntington Disease 23145961 nervous system disease DOID:12858 G10 D006816 143100 We also identified several microRNAs (miRNAs) whose aberrant repression is directly mediated by REST, including miR-137, which has not previously been shown to be a direct REST target in mouse. other hsa-mir-148a Huntington Disease 23965969 nervous system disease DOID:12858 G10 D006816 143100 Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs. other hsa-mir-196a Huntington Disease 23810380 nervous system disease DOID:12858 G10 D006816 143100 miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models. other hsa-mir-196a Huntington Disease 27631085 nervous system disease DOID:12858 G10 D006816 143100 miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells. other hsa-mir-214 Huntington Disease 23965969 nervous system disease DOID:12858 G10 D006816 143100 Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs. other hsa-mir-126 Hyperglycemia 27673690 disease of metabolism DOID:4195 E78.1 D006943 HP:0003074 Hyperglycemia and Advanced Glycation End Products Regulate miR-126 Expression in Endothelial Progenitor Cells. other hsa-mir-221 Hyperglycemia 19351599 disease of metabolism DOID:4195 E78.1 D006943 HP:0003074 miR-221: induced expression other hsa-mir-24 Hyperglycemia 26022048 disease of metabolism DOID:4195 E78.1 D006943 HP:0003074 In this issue of Blood, Xiang et al identify a novel mechanism, involving activation of the polyol pathway and repression of microRNA-24 (miR-24), through which hyperglycemia augments von Willebrand factor (VWF) expression and secretion. other hsa-mir-24 Hyperlipidemia 24677249 E78.4 D006949 HP:0003077 Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. other hsa-mir-33a Hyperlipidemia 24928089 E78.4 D006949 HP:0003077 all selected miRNAs were detected in 伪-lipoprotein fraction from sera, and miR-33a was also present in 尾-lipoprotein fraction; other hsa-mir-103a-1 Hypertension 21753805 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension. other hsa-mir-103a-2 Hypertension 21753805 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension. other hsa-mir-126 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-133a Hypertension 24937684 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 These results suggest that high salt intervention could down-regulate the expression of myocardial microRNA-133a, which may be one of the mechanisms involved in myocardial fibrosis in salt-sensitive hypertension. other hsa-mir-155 Hypertension 27683672 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. other hsa-mir-155 Hypertension 28360962 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. other hsa-mir-155 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-17 Hypertension 22161164 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Inhibition of microRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension. other hsa-mir-17 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-204 Hypertension 21890685 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 These effects were associated with the inhibition of Src, STAT3, Pim1, NFATc2, and Survivin and the upregulation of BMPR2 and miR-204. other hsa-mir-204 Hypertension 22534459 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 This correlates with a down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs, which in turn corresponds to enhanced cell proliferation. other hsa-mir-204 Hypertension 27438705 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers. other hsa-mir-204 Hypertension 28473439 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. other hsa-mir-204 Hypertension 28565757 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 An exploratory study into the role of miR-204-5p in pregnancy-induced hypertension. other hsa-mir-204 Hypertension 29196166 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 1,25(OH)2D3 was a promising therapeutic modality for treatment of PAH, function of which was exerted through miR-204 mediated Tgfbr2 signaling other hsa-mir-208a Hypertension 22666483 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 this work reveals an original aldosterone-dependent inhibition of miR-208a in hypertension, resulting in the inhibition of β-myosin heavy chain expression through the induction of its transcriptional repressor Sox6. other hsa-mir-208b Hypertension 22666483 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Besides, the AH-induced increase of ßMyHC and its intronic miRNA-208b was prevented in AS-Ren. other hsa-mir-208b Hypertension 29506053 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity other hsa-mir-20a Hypertension 22450430 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. other hsa-mir-21 Hypertension 22371328 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension other hsa-mir-21 Hypertension 22534459 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 This correlates with a down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs, which in turn corresponds to enhanced cell proliferation. other hsa-mir-21 Hypertension 28360962 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. other hsa-mir-221 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-222 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-223 Hypertension 28473439 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. other hsa-mir-24 Hypertension 23836801 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. other hsa-mir-26b Hypertension 29506053 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity other hsa-mir-30a Hypertension 23817492 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 miR-30a regulates endothelial tip cell formation and arteriolar branching. other hsa-mir-31 Hypertension 21946298 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation. other hsa-mir-425 Hypertension 27132035 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo other hsa-mir-499 Hypertension 29506053 cardiovascular system disease DOID:10763 I10 D006973 145500 HP:0000822 miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity other hsa-mir-1-1 Hypertrophy 20619221 D006984 miR-1:have a profound influence on multiple myopathies other hsa-mir-1-2 Hypertrophy 20619221 D006984 miR-1:have a profound influence on multiple myopathies other hsa-mir-133a-1 Hypertrophy 20619221 D006984 miR-133:have a profound influence on multiple myopathies other hsa-mir-133a-2 Hypertrophy 20619221 D006984 miR-133:have a profound influence on multiple myopathies other hsa-mir-142 Hypertrophy 22367739 D006984 Repression of miR-142 by p300 and MAPK is required for survival signaling via gp130 during adaptive hypertrophy. other hsa-mir-206 Hypertrophy 20619221 D006984 miR-206:have a profound influence on multiple myopathies other hsa-mir-208a Hypertrophy 17786230 D006984 Clearly, miR-208 is also essential for expression of the genes involved in cardiac fibrosis and hypertrophic growth. other hsa-mir-21 Hypertrophy 22879939 D006984 TGFbeta-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion. other hsa-mir-23a Hypertrophy 22084234 D006984 Cardiac hypertrophy is positively regulated by miR-23a. other hsa-mir-26a-1 Hypertrophy 20525681 D006984 MiR-26a:stretch or enforced expression of miR-26a induces HASMC hypertrophy other hsa-mir-26a-2 Hypertrophy 20525681 D006984 MiR-26a:stretch or enforced expression of miR-26a induces HASMC hypertrophy other hsa-mir-26b Hypertrophy 22219180 D006984 GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. other hsa-mir-375 Hypogonadism 26219823 endocrine system disease DOID:1924 D007006 241100 we identified miR-375 as an androgen regulated microRNA, which could play an important role for understanding the mechanism of the increase in visceral fat mass and the associated insulin resistance caused by testosterone deficiency. other hsa-mir-676 Hypohidrotic Ectodermal Dysplasia 29106399 musculoskeletal system disease DOID:14793 D053358 PS305100 HP:0007607 A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. other hsa-mir-155 Hypoxia 27587248 D000860 Effect of miR- 155 on immune- factors and its mechanism in mesenchymal stem cells under hypoxic environment. other hsa-mir-18a Hypoxia 29363860 D000860 ACE-EPCs-EXs have better protective effects on H/R injury in ageing ECs which could be through their carried miR-18a and subsequently down-regulating the Nox2/ROS pathway other hsa-mir-34a Hypoxia 29581146 D000860 Inhibition of miR-34a-5p alleviates hypoxia-reoxygenation injury by enhancing autophagy in steatotic hepatocytes other hsa-mir-34b Hypoxia 25982511 D000860 Sevoflurane preconditioning-inhibited apoptosis and preconditioning-enhanced cell viability of PC12 cells were significantly attenuated by transfection of miR-101a mimetic or miR-34b inhibitors, but were significantly enhanced by transfection of miR-34b mimetic. other hsa-mir-17 Hypoxic-Ischemic Encephalopathy 29394934 P91.60 D020925 IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats other hsa-let-7d Idiopathic Pulmonary Fibrosis 20395557 respiratory system disease DOID:0050156 J84.112 D054990 178500 The down-regulation of let-7d in IPF and the profibrotic effects of this down-regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis. other hsa-let-7d Idiopathic Pulmonary Fibrosis 26787543 respiratory system disease DOID:0050156 J84.112 D054990 178500 Lin28B causes epithelial-mesenchymal transition (EMT) by inhibition of let-7d. other hsa-mir-26a Idiopathic Pulmonary Fibrosis 24853416 respiratory system disease DOID:0050156 J84.112 D054990 178500 Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis. other hsa-mir-155 IgA Nephropathy 27796698 urinary system disease DOID:2986 N02.8 D005922 161950 HP:0000794 MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy. other hsa-mir-21 IgA Nephropathy 24468088 urinary system disease DOID:2986 N02.8 D005922 161950 HP:0000794 Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy. other hsa-let-7i Immune System Disease [unspecific] 21742974 immune system disease DOID:2914 D89.9 D007154 Dynamic regulation of let-7i may fine-tune immune responses by inducing Ag-specific immune tolerance. other hsa-mir-146 Immune System Disease [unspecific] 26400897 immune system disease DOID:2914 D89.9 D007154 Present review is focused on the current knowledge about the action of medicaments,microRNA molecules, exosomes and related vesicles on macrophages leading to modulation of their biological activity. other hsa-mir-146a Immune System Disease [unspecific] 19965651 immune system disease DOID:2914 D89.9 D007154 Our results demonstrate that several signaling pathways, other than inflammation, are influenced by miR-146a. In particular, we provide experimental evidence that miR-146a modulates activation-induced cell death (AICD), acting as an antiapoptotic factor, and that Fas-associated death domain (FADD) is a target of miR-146a. other hsa-mir-150 Immune System Disease [unspecific] 25690461 immune system disease DOID:2914 D89.9 D007154 Our current studies characterized TsF as regulatory miRNA-150 carried by T suppressor cell-derived exosomes that are antigen specific due to a surface coat of IgM antibody light chains produced by B1a cells. other hsa-mir-155 Immune System Disease [unspecific] 24303979 immune system disease DOID:2914 D89.9 D007154 Role of miR-155 in the regulation of lymphocyte immune function and disease. other hsa-mir-155 Immune System Disease [unspecific] 23949802 immune system disease DOID:2914 D89.9 D007154 MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN. other hsa-mir-15a Immune System Disease [unspecific] 22578383 immune system disease DOID:2914 D89.9 D007154 In conclusion, our data support the involvement of elevated miR-15a in autoimmune disease development in B/W mice and suggest that decreasing this microRNA might be beneficial in B/W mice. other hsa-mir-2909 Immune System Disease [unspecific] 25500259 immune system disease DOID:2914 D89.9 D007154 a mechanistic-pathway is proposed that links the epigenomic-interplay between MALT1 and miR-2909. other hsa-mir-9 Immune System Disease [unspecific] 22585398 immune system disease DOID:2914 D89.9 D007154 Using microarray and deep sequencing approaches, we detected an increase in the abundance of miR-9 in activated human CD4(+) T cells. other hsa-mir-92a Immune System Disease [unspecific] 23355465 immune system disease DOID:2914 D89.9 D007154 we have demonstrated that TLR-mediated miR-92a reduction feedback enhances TLR-triggered production of inflammatory cytokines in macrophages, thus outlining new mechanisms for fine-tuning the TLR-triggered inflammatory response. other hsa-let-7 Infection [unspecific] 19592657 D007239 Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response. other hsa-let-7i Infection [unspecific] 29069656 D007239 Cyclosporine A Induces MicroRNAs Controlling Innate Immunity during Renal Bacterial Infection. other hsa-mir-100 Infection [unspecific] 28181552 D007239 MicroRNA-100 is involved in shrimp immune response to white spot syndrome virus (WSSV) and Vibrio alginolyticus infection. other hsa-mir-132 Infection [unspecific] 29467760 D007239 MicroRNA Regulation of Host Immune Responses following Fungal Exposure other hsa-mir-140 Infection [unspecific] 27749761 D007239 Microrna Expression Profiling of Macrophage Line Raw264.7 Infected by Candida Albicans. other hsa-mir-143 Infection [unspecific] 28870451 D007239 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. other hsa-mir-146a Infection [unspecific] 29467760 D007239 MicroRNA Regulation of Host Immune Responses following Fungal Exposure other hsa-mir-146a Infection [unspecific] 27297392 D007239 miR-146a was found to be differentially regulated in THP-1 cells between probiotic and pathogenic bacteria. other hsa-mir-146a Infection [unspecific] 28319200 D007239 Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera. other hsa-mir-155 Infection [unspecific] 26072128 D007239 An update on the role of miRNA-155 in pathogenic microbial infections. other hsa-mir-155 Infection [unspecific] 28319200 D007239 Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera. other hsa-mir-15a Infection [unspecific] 22953717 D007239 Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection. other hsa-mir-181 Infection [unspecific] 28870451 D007239 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. other hsa-mir-21 Infection [unspecific] 28870451 D007239 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. other hsa-mir-21 Infection [unspecific] 28589100 D007239 MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. other hsa-mir-21 Infection [unspecific] 28083515 D007239 Genome-Wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus. other hsa-mir-221 Infection [unspecific] 29698854 D007239 Avian leukosis virus subgroup J promotes cell proliferation and cell cycle progression through miR-221 by targeting CDKN1B. other hsa-mir-223 Infection [unspecific] 28083515 D007239 Genome-Wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus. other hsa-mir-29b Infection [unspecific] 28394930 D007239 Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia. other hsa-mir-451 Infection [unspecific] 28378118 D007239 miR-451 limits CD4+ T cell proliferative responses to infection in mice. other hsa-mir-451 Infection [unspecific] 22953717 D007239 Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection. other hsa-mir-664 Infection [unspecific] 22953717 D007239 Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection. other hsa-mir-9 Infection [unspecific] 28031262 D007239 Pseudomonas aeruginosa GroEL Stimulates Production of PTX3 by Activating the NF-κB Pathway and Simultaneously Downregulating MicroRNA-9. other hsa-mir-98 Infection [unspecific] 19592657 D007239 Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response. other hsa-mir-155 Infectious Bursal Disease Virus 29564226 D007243 gga-miR-155 plays a critical role in cell response to IBDV infection other hsa-mir-122 Infertility 26648257 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. other hsa-mir-17 Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-18 Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-19a Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-19b-1 Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-20a Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-34c Infertility 26648257 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. other hsa-mir-449a Infertility 26648257 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. other hsa-mir-92-1 Infertility 29402772 reproductive system disease DOID:5223 N46.9/N97.9 D007246 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice other hsa-mir-1 Inflammation 21385380 D007249 Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression. other hsa-mir-101 Inflammation 26087518 D007249 Advances in understanding the roles of microRNA-101 in inflammation, fibrosis and cancer other hsa-mir-122 Inflammation 26657215 D007249 In addition to the classical Jak-Stat antiviral signaling pathway,IFN-λ1 inhibits HCV replication through the suppression of miRNA-122 transcription via an inflammatory Stat 3-HNF4α feedback loop. Inflammatory feedback circuits activated by IFNs during chronic inflammation expose non-responders to the risk of hepatocellular carcinoma. other hsa-mir-125b Inflammation 20435889 D007249 The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis. other hsa-mir-125b Inflammation 22456625 D007249 Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation. other hsa-mir-125b Inflammation 29354323 D007249 Up-Regulation of the Pro-Inflammatory Cytokines IL-6 and TNFα, C-Reactive Protein (CRP) and miRNA-146a in Blood Serum other hsa-mir-126 Inflammation 22419694 D007249 MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. other hsa-mir-126 Inflammation 25300227 D007249 Polyphenolic extracts from cowpea (Vigna unguiculata) protect colonic myofibroblasts (CCD18Co cells) from lipopolysaccharide (LPS)-induced inflammation--modulation of microRNA 126. other hsa-mir-132 Inflammation 20005135 D007249 MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase other hsa-mir-132 Inflammation 20064444 D007249 Boosting the brain's ability to block inflammation via microRNA-132. other hsa-mir-132 Inflammation 22362752 D007249 we propose an outline of the current knowledge about miR-132 and miR-212 functions in neurons and immune cells other hsa-mir-132 Inflammation 28209997 D007249 Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation. other hsa-mir-132 Inflammation 27378528 D007249 LPS down-regulated the expression of miRNA-132. other hsa-mir-143 Inflammation 26739093 D007249 Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin other hsa-mir-146 Inflammation 24035832 D007249 Our findings reveal a novel regulatory module of two miRNA-mediated negative feedback loops that allows for the fine-tuning of the dynamics of key mediators in inflammation. other hsa-mir-146 Inflammation 29601548 D007249 the NF-κB-miR-146 and NF-κB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-κB-miR-21 and NF-κB-miR-181b-1 amplifying loops link inflammation to cancer other hsa-mir-146a Inflammation 20214679 D007249 miR-146a in reactive astrocytes supports the possible involvement of miRNAs in the modulation of the astroglial inflammatory response other hsa-mir-146a Inflammation 20384865 D007249 functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases other hsa-mir-146a Inflammation 25805648 D007249 the model of endotoxin tolerance is suitable for the antagonistic effects on the dysregulation of ABCA1/G1 induced by high dose of P.g LPS.Conversely, low-dose AGEs did not induce the model of P.g LPS-mediated tolerance. other hsa-mir-146a Inflammation 26956852 D007249 Effect of High MiR-146a Expression on the Inflammatory Reaction in BV2 Cells. other hsa-mir-146a Inflammation 22371089 D007249 miR-146a and miR-147 are involved in the resolution phase of inflammation. other hsa-mir-146a Inflammation 27256622 D007249 These effects were partially mediated through RvD2 induction of microRNA-146a other hsa-mir-146a Inflammation 27998828 D007249 we reported an anti-inflammatory effect of resveratrol and hydroxytyrosol at low, nutritionally relevant concentrations, involving the inhibition of granulocytes and monocytes activation, the modulation of miR-146a expression and the activation of Nrf2 other hsa-mir-146a Inflammation 26718614 D007249 miR-146a inhibits inflammatory activation. other hsa-mir-146b Inflammation 18390754 D007249 Overall, these studies indicate that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response. other hsa-mir-147 Inflammation 22371089 D007249 miR-146a and miR-147 are involved in the resolution phase of inflammation. other hsa-mir-155 Inflammation 21282106 D007249 Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyper-expression of interleukin-8. other hsa-mir-155 Inflammation 18940871 D007249 Finally, we demonstrate that LMP1-mediated activation of miR-155 in an EBV-negative background correlates with reduction of protein PU.1, which is a possible miR target. other hsa-mir-155 Inflammation 27981414 D007249 MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases. other hsa-mir-155 Inflammation 29601548 D007249 the NF-κB-miR-146 and NF-κB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-κB-miR-21 and NF-κB-miR-181b-1 amplifying loops link inflammation to cancer other hsa-mir-16 Inflammation 21385380 D007249 Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression. other hsa-mir-181a Inflammation 18291670 D007249 MiRNAs are implicated in establishing and maintaining the cell fate of immune cells (e.g. miR-181a and miR-223), and they are involved in innate immunity by regulating Toll-like receptor signaling and ensuing cytokine response (e.g. miR-146). other hsa-mir-181a Inflammation 29535629 D007249 we provide the first evidence for the negative regulation of miR-181a in LPS-induced inflammation via the suppression of ROS generation and TLR4-NF-κB pathway other hsa-mir-181a-2 Inflammation 23220232 D007249 miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo other hsa-mir-182 Inflammation 28045967 D007249 Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis. other hsa-mir-183 Inflammation 28045967 D007249 Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis. other hsa-mir-203 Inflammation 18291670 D007249 MiRNAs are implicated in establishing and maintaining the cell fate of immune cells (e.g. miR-181a and miR-223), and they are involved in innate immunity by regulating Toll-like receptor signaling and ensuing cytokine response (e.g. miR-146). other hsa-mir-206 Inflammation 21385380 D007249 Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression. other hsa-mir-21 Inflammation 24035832 D007249 Our findings reveal a novel regulatory module of two miRNA-mediated negative feedback loops that allows for the fine-tuning of the dynamics of key mediators in inflammation. other hsa-mir-210 Inflammation 20237418 D007249 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state other hsa-mir-210 Inflammation 21467158 D007249 miRNA-210 is a good example in this category that impairs wound closure. other hsa-mir-210 Inflammation 27983913 D007249 Precise Regulation of miR-210 Is Critical for the Cellular Homeostasis Maintenance and Transplantation Efficacy Enhancement of Mesenchymal Stem Cells in Acute Liver Failure Therapy. other hsa-mir-210 Inflammation 28188219 D007249 Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement. other hsa-mir-212 Inflammation 22362752 D007249 we propose an outline of the current knowledge about miR-132 and miR-212 functions in neurons and immune cells other hsa-mir-219-2 Inflammation 22957142 D007249 Delayed resolution undermines endogenous resolution programs, altering miR-219-2 expression, increasing pro-inflammatory mediators and compromising SPM production that contribute to failed catabasis and homeostasis. other hsa-mir-22 Inflammation 26088024 D007249 extracellular Adenosine and uridine triphosphate (ATP and UTP) can attenuate ICAM-1 expression and leukocyte adhesion in endothelial cells through miR-22. other hsa-mir-221 Inflammation 20110463 D007249 Functional inhibition of miR-221 with anti-miR-221 induced ICAM-1 protein expression. Moreover, IFN-gamma stimulation decreased miR-221 expression in cholangiocytes in a signal transducer and activator of transcription 1-dependent manner. other hsa-mir-221 Inflammation 20435889 D007249 The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis. other hsa-mir-221 Inflammation 27731391 D007249 Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. other hsa-mir-222 Inflammation 26081516 D007249 In pathological hyperglycaemic conditions, EMP-mediated miR-222-dependent anti-inflammatory effects are reduced. other hsa-mir-223 Inflammation 25997943 D007249 we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose. other hsa-mir-223 Inflammation 27999792 D007249 Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. other hsa-mir-223 Inflammation 29444433 D007249 MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation other hsa-mir-24-1 Inflammation 21282569 D007249 Role of miR-204 in the regulation of apoptosis, ER stress response, and inflammation in human trabecular meshwork cells. other hsa-mir-24-2 Inflammation 21282569 D007249 Role of miR-204 in the regulation of apoptosis, ER stress response, and inflammation in human trabecular meshwork cells. other hsa-mir-27b Inflammation 20164187 D007249 We provide evidence that LPS-induced miR-27b contributes to destabilization of PPARgamma1 mRNA. Understanding molecular mechanisms decreasing PPARgamma might help to better appreciate inflammatory diseases. other hsa-mir-29a Inflammation 25997943 D007249 we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose. other hsa-mir-33a Inflammation 21285396 D007249 miR-33 reduces RIP140 coactivator activity for NF-kB, which is supported by the reduction in NF-kB reporter activity and the inflammatory potential in macrophages. other hsa-mir-33b Inflammation 21285396 D007249 miR-33 reduces RIP140 coactivator activity for NF-kB, which is supported by the reduction in NF-kB reporter activity and the inflammatory potential in macrophages. other hsa-mir-34a Inflammation 25997943 D007249 we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose. other hsa-mir-424 Inflammation 25997943 D007249 we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose. other hsa-mir-4661 Inflammation 24238336 D007249 The bipolar role of miR-4661 in inflammation. other hsa-mir-579 Inflammation 20435889 D007249 The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis. other hsa-mir-93 Inflammation 24433094 D007249 Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses. other hsa-mir-98 Inflammation 27913008 D007249 MicroRNA-98 plays a critical role in experimental myocarditis. other hsa-mir-100 Inflammation 26209130 D007249 Such delicately counterbalanced systems are a hallmark of immune plasticity and we propose that miR-100 editing is a novel mechanism toward this end. other hsa-mir-125b Inflammation 26954942 D007249 MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response. other hsa-mir-1270 Inflammation 25746225 D007249 This coordinated regulatory architecture suggests a vital function for the innate immune system in maintaining precise physiological type I IFN levels via post-transcriptional regulatory mechanisms. other hsa-mir-146a Inflammation 24607549 D007249 In conclusion several aging-related mitomiRs may play a direct role in controlling mitochondrial function by regulating mitochondrial protein expression. Their modulation could thus mediate the loss of mitochondrial integrity and function in aging cells, inducing or contributing to the inflammatory response and to age-related diseases. other hsa-mir-17 Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-18 Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-19a Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-19b Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-19b-1 Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-20a Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-21 Inflammation 27075111 D007249 Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. other hsa-mir-24 Inflammation 25358394 D007249 miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. other hsa-mir-26a Inflammation 27075111 D007249 Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. other hsa-mir-33a Inflammation 25329888 D007249 Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages. other hsa-mir-34a Inflammation 24607549 D007249 In conclusion several aging-related mitomiRs may play a direct role in controlling mitochondrial function by regulating mitochondrial protein expression. Their modulation could thus mediate the loss of mitochondrial integrity and function in aging cells, inducing or contributing to the inflammatory response and to age-related diseases. other hsa-mir-449c Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-455 Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-92-1 Inflammation 25979460 D007249 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. other hsa-mir-129 Inflammatory Bowel Diseases 26003847 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases. other hsa-mir-133a Inflammatory Bowel Diseases 28104982 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism. other hsa-mir-155 Inflammatory Bowel Diseases 23288924 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 OVER EXPRESSION OF MICRORNAS-155 AND 21 TARGETING MISMATCH REPAIR PROTEINS IN INFLAMMATORY BOWEL DISEASES other hsa-mir-186 Inflammatory Bowel Diseases 26003847 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases. other hsa-mir-200c Inflammatory Bowel Diseases 26003847 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases. other hsa-mir-21 Inflammatory Bowel Diseases 23224068 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis other hsa-mir-21 Inflammatory Bowel Diseases 23288924 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 OVER EXPRESSION OF MICRORNAS-155 AND 21 TARGETING MISMATCH REPAIR PROTEINS IN INFLAMMATORY BOWEL DISEASES other hsa-mir-31 Inflammatory Bowel Diseases 25665881 gastrointestinal system disease DOID:0050589 D015212 PS266600 HP:0002037 Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. other hsa-let-7b Influenza 25788763 respiratory system disease DOID:8469 J09-J11 D007251 614680 This approach provides an additional layer of biosafety and thus has great potential for the application in the rational development of safer and more effective influenza viral vaccines. other hsa-let-7b Influenza 26163223 respiratory system disease DOID:8469 J09-J11 D007251 614680 These results indicate that the influenza virus containing microRNA response elements (MREs) is attenuated in vivo and can be used to design a live attenuated vaccine. other hsa-let-7c Influenza 22452878 respiratory system disease DOID:8469 J09-J11 D007251 614680 Cellular MicroRNA let-7c Inhibits M1 Protein Expression of the H1N1 Influenza A Virus in Infected Human Lung Epithelial Cells. other hsa-mir-126 Influenza 28282445 respiratory system disease DOID:8469 J09-J11 D007251 614680 Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. other hsa-mir-146a Influenza 23343627 respiratory system disease DOID:8469 J09-J11 D007251 614680 Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a other hsa-mir-148a Influenza 23731466 respiratory system disease DOID:8469 J09-J11 D007251 614680 QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus other hsa-mir-150 Influenza 26148929 respiratory system disease DOID:8469 J09-J11 D007251 614680 The up-regulation of miR-150 is associated with poorer outcomes of A/H1N1 infection. The differential expression of miRNAs related with immune processes in severe A/H1N1 disease supports the potential role of these miRNAs as biomarkers of disease progression. other hsa-mir-155 Influenza 28392443 respiratory system disease DOID:8469 J09-J11 D007251 614680 Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome. other hsa-mir-15b Influenza 21872652 respiratory system disease DOID:8469 J09-J11 D007251 614680 Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. other hsa-mir-192 Influenza 23934176 respiratory system disease DOID:8469 J09-J11 D007251 614680 MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies. other hsa-mir-29a Influenza 26000345 respiratory system disease DOID:8469 J09-J11 D007251 614680 With assay optimization, the detection limit of our MARS assay for miR-29a-3p was found to be 1 nM, and this new assay could be completed within 1 hour without thermal cycling. This non-PCR assay with high selectivity for mature microRNA provides a new platform for rapid disease diagnosis, quarantine and disease control. other hsa-mir-29a Influenza 23731466 respiratory system disease DOID:8469 J09-J11 D007251 614680 QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus other hsa-mir-29c Influenza 24953694 respiratory system disease DOID:8469 J09-J11 D007251 614680 Induction of the cellular miR-29c by influenza virus inhibits the innate immune response through protection of A20 mRNA. other hsa-mir-30 Influenza 26296570 respiratory system disease DOID:8469 J09-J11 D007251 614680 RNA interference of influenza A virus replication by microRNA-adapted lentiviral loop short hairpin RNA. other hsa-mir-31 Influenza 23731466 respiratory system disease DOID:8469 J09-J11 D007251 614680 QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus other hsa-mir-33a Influenza 26498766 respiratory system disease DOID:8469 J09-J11 D007251 614680 In conclusion, we found that miR-33a is a novel inhibitory factor for influenza A virus replication. other hsa-mir-548a Influenza 24210102 respiratory system disease DOID:8469 J09-J11 D007251 614680 Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus. other hsa-mir-590 Influenza 29677213 respiratory system disease DOID:8469 J09-J11 D007251 614680 IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs other hsa-mir-650 Influenza 26460926 respiratory system disease DOID:8469 J09-J11 D007251 614680 Together these findings reveal a novel link between miR-650 and the innate immune response in human MDDCs. other hsa-mir-137 Intellectual Disability 26095359 disease of mental health DOID:1059 F79 D008607 617991 Our findings suggest that miR-137 is a key factor in the control of synaptic efficacy and mGluR-dependent synaptic plasticity, supporting the notion that glutamatergic dysfunction contributes to the pathogenesis of miR-137-linked cognitive impairments. other hsa-mir-199a-1 Interstitial Cystitis 23201090 urinary system disease DOID:13949 N30.10-.11 D018856 miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome other hsa-mir-199a-2 Interstitial Cystitis 23201090 urinary system disease DOID:13949 N30.10-.11 D018856 miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome other hsa-mir-222 Intervertebral Disc Degeneration 26134418 musculoskeletal system disease DOID:90 M51 D055959 603932 HP:0008419 a comprehensive microRNA-222 and microRNA-589 gene regulatory network was constructed, which was found to be important in IDD progression. other hsa-mir-589 Intervertebral Disc Degeneration 26134418 musculoskeletal system disease DOID:90 M51 D055959 603932 HP:0008419 a comprehensive microRNA-222 and microRNA-589 gene regulatory network was constructed, which was found to be important in IDD progression. other hsa-mir-31 Intestinal Schistosomiasis 19997615 disease by infectious agent DOID:0050597 B65.1 D012554 181460 some nucleotides at many positions of Schistosoma miRNAs, such as miR-8, let-7, miR-10, miR-31, miR-92, miR-124, and miR-125, are indeed significantly distinct from other bilaterian orthologs other hsa-mir-155 Intracerebral Hemorrhage 19724284 I60.1 D002543 HP:0001342 correlate other hsa-mir-298 Intracerebral Hemorrhage 19724284 I60.1 D002543 HP:0001342 correlate other hsa-mir-362 Intracerebral Hemorrhage 19724284 I60.1 D002543 HP:0001342 correlate other hsa-mir-126 Intracerebral Hemorrhage 28112373 I60.1 D002543 HP:0001342 Protective role of microRNA-126 in intracerebral hemorrhage. other hsa-mir-132 Intracerebral Hemorrhage 27940326 I60.1 D002543 HP:0001342 MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. other hsa-mir-195 Intrahepatic Cholangiocarcinoma 27474881 disease of cellular proliferation DOID:4928 C22.1 D018281 615619 Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model. other hsa-mir-221 Intrahepatic Cholangiocarcinoma 27280413 disease of cellular proliferation DOID:4928 C22.1 D018281 615619 no correlation was found between the expression levels of these molecular markers and histopathological differentiation grade. other hsa-mir-29a Irritable Bowel Syndrome 19951903 syndrome DOID:9778 K58 D043183 miR-29a:MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome other hsa-mir-126 Ischemia 21856785 cardiovascular system disease DOID:326 D007511 601367 MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1+/Lin- progenitor cells in ischemia. other hsa-mir-126 Ischemia 29242072 cardiovascular system disease DOID:326 D007511 601367 Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia other hsa-mir-155 Ischemia 22052914 cardiovascular system disease DOID:326 D007511 601367 Inhibition of miR-15 Protects Against Cardiac Ischemic Injury. other hsa-mir-210 Ischemia 20237418 cardiovascular system disease DOID:326 D007511 601367 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state other hsa-mir-592 Ischemia 29402808 cardiovascular system disease DOID:326 D007511 601367 Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR. other hsa-mir-146a Ischemia-Reperfusion Injury 28771774 D015427 MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-κB pathway. other hsa-mir-155 Ischemia-Reperfusion Injury 25916938 D015427 MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst. other hsa-mir-155 Ischemia-Reperfusion Injury 28640790 D015427 MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice. other hsa-mir-192 Ischemia-Reperfusion Injury 27870736 D015427 Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury. other hsa-mir-192 Ischemia-Reperfusion Injury 28035621 D015427 Implications of dynamic changes in miR-192 expression in ischemic acute kidney injury. other hsa-mir-204 Ischemia-Reperfusion Injury 28714326 D015427 miR-204 inhibitor upregulated the activity and expression of RAP2C, while miR-204 mimic played the opposite role other hsa-mir-21 Ischemia-Reperfusion Injury 25159851 D015427 miR-21 in ischemia/reperfusion injury: a double-edged sword other hsa-mir-21 Ischemia-Reperfusion Injury 24676391 D015427 microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. other hsa-mir-21 Ischemia-Reperfusion Injury 26168042 D015427 losartan treatment significantly increased microRNA (miR)-1, -15b, -92a, -133a, -133b, -210, and -499 expression but decreased miR-21 in the left ventricle. other hsa-mir-21 Ischemia-Reperfusion Injury 22785173 D015427 Thus, upregulation of miR-21 contributes to the protective effect of delayed ischemic preconditioning against subsequent renal ischemia-reperfusion injury. other hsa-mir-21 Ischemia-Reperfusion Injury 23719532 D015427 MiR-21 expression is down-regulated and cell apoptosis is increased in rat myocardium during early ischemia-reperfusion injury. other hsa-mir-21 Ischemia-Reperfusion Injury 25536091 D015427 isoflurane mediates protection of cardiomyocytes against oxidative stress via an miR-21/programmed cell death protein 4 pathway. other hsa-mir-21 Ischemia-Reperfusion Injury 26259139 D015427 Isoflurane protects mouse hearts from ischemia-reperfusion injury by a microRNA-21-dependent mechanism. other hsa-mir-21 Ischemia-Reperfusion Injury 27804287 D015427 Fluorescent Nanocomposite for Visualizing Cross-Talk between MicroRNA-21 and Hydrogen Peroxide in Ischemia-Reperfusion Injury in Live Cells and In Vivo. other hsa-mir-21 Ischemia-Reperfusion Injury 29170412 D015427 Ischemic Postconditioning Protects Against Intestinal Ischemia/Reperfusion Injury via the HIF-1α/miR-21 Axis other hsa-mir-21 Ischemia-Reperfusion Injury 29187695 D015427 the activation of the Akt pathway regulated by miR-21 participates in the protective effects of H2S against I/R-induced liver injury other hsa-mir-21 Ischemia-Reperfusion Injury 29506703 D015427 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction other hsa-mir-223 Ischemia-Reperfusion Injury 27635859 D015427 Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats. other hsa-mir-24 Ischemia-Reperfusion Injury 24854275 D015427 MicroRNA-24 antagonism prevents renal ischemia reperfusion injury. other hsa-mir-27a Ischemia-Reperfusion Injury 24009229 D015427 Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. other hsa-mir-34a Ischemia-Reperfusion Injury 28599575 D015427 Suppression of miR-34a Expression in the Myocardium Protects Against Ischemia-Reperfusion Injury Through SIRT1 Protective Pathway. other hsa-mir-34a Ischemia-Reperfusion Injury 28709867 D015427 Attenuation of the hypoxia-induced miR-34a protects cardiomyocytes through maintenance of glucose metabolism. other hsa-mir-92a Ischemia-Reperfusion Injury 23897866 D015427 Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. other hsa-mir-144 Ischemic Diseases [unspecific] 25060662 D007511 601367 MicroRNA-144 is a circulating effector of remote ischemic preconditioning. other hsa-mir-199a Ischemic Diseases [unspecific] 21464712 D007511 601367 On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia. other hsa-mir-21 Ischemic Diseases [unspecific] 21464712 D007511 601367 On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia. other hsa-mir-210 Ischemic Diseases [unspecific] 22833359 D007511 601367 miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia. other hsa-mir-210 Ischemic Diseases [unspecific] 21464712 D007511 601367 On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia. other hsa-mir-210 Ischemic Diseases [unspecific] 22123256 D007511 601367 Upregulation of microRNA-210 regulates renal angiogenesis mediated by activation of VEGF signaling pathway under ischemia/perfusion injury in vivo and in vitro. other hsa-mir-221 Ischemic Diseases [unspecific] 25796380 D007511 601367 Moreover, exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression. other hsa-mir-222 Ischemic Diseases [unspecific] 25796380 D007511 601367 Moreover, exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression. other hsa-mir-487b Ischemic Diseases [unspecific] 25085941 D007511 601367 The 14q32 microRNA gene cluster is highly involved in neovascularization. other hsa-mir-494 Ischemic Diseases [unspecific] 25085941 D007511 601367 The 14q32 microRNA gene cluster is highly involved in neovascularization. other hsa-mir-494 Ischemic Diseases [unspecific] 21464712 D007511 601367 On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia. other hsa-mir-494 Ischemic Diseases [unspecific] 28624225 D007511 601367 Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494. other hsa-mir-494 Ischemic Diseases [unspecific] 28880896 D007511 601367 Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494. other hsa-mir-495 Ischemic Diseases [unspecific] 25085941 D007511 601367 The 14q32 microRNA gene cluster is highly involved in neovascularization. other hsa-let-7 Ischemic Heart Disease 26588727 I25.9/I24.9 D017202 Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. other hsa-mir-18a Ischemic Heart Disease 24903055 I25.9/I24.9 D017202 PNS treatment resulted in reduced expression of miR-18a in tumor and upregulated expression of miR-18a in heart. other hsa-mir-21 Ischemic Heart Disease 29444190 I25.9/I24.9 D017202 Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis other hsa-mir-146a Japanese Encephalitis Virus Infection 25889446 A83.0 D018349 Upregulation of miR-146a by JEV JaOArS982 strain leads to suppression of NF-κB activity and disruption of antiviral Jak-STAT signaling which helps the virus to evade the cellular immune response. This effect of JEV infection on miR-146a expression was found to be strain specific. other hsa-mir-146a Kaposi Sarcoma 20023696 disease of cellular proliferation DOID:8632 C46 D012514 Our results show that K13-induced NF-kappaB activity suppresses CXCR4 through upregulation of miR-146a. other hsa-mir-155 Kaposi Sarcoma 17881434 disease of cellular proliferation DOID:8632 C46 D012514 Together, these findings indicate that KSHV miR-K12-11 is an ortholog of miR-155. other hsa-mir-155 Kaposi Sarcoma 18191785 disease of cellular proliferation DOID:8632 C46 D012514 Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis. other hsa-mir-17 Kaposi Sarcoma 27512057 disease of cellular proliferation DOID:8632 C46 D012514 Here, we provide the first experimental evidence of JMRV miRNAs in vitro and demonstrate that one of these viral miRNAs can mimic the activity of the cellular miR-17/20/106 family. other hsa-mir-21 Kaposi Sarcoma 18971265 disease of cellular proliferation DOID:8632 C46 D012514 Therefore, K15M may contribute to KSHV-mediated tumor metastasis and angiogenesis via regulation of miR-21 and miR-31, which we show here for the first time to be a specific regulator of cell migration. other hsa-mir-23 Kaposi Sarcoma 23986579 disease of cellular proliferation DOID:8632 C46 D012514 Kaposi's sarcoma-associated herpesvirus encodes a mimic of cellular miR-23. other hsa-mir-31 Kaposi Sarcoma 18971265 disease of cellular proliferation DOID:8632 C46 D012514 Therefore, K15M may contribute to KSHV-mediated tumor metastasis and angiogenesis via regulation of miR-21 and miR-31, which we show here for the first time to be a specific regulator of cell migration. other hsa-mir-409 Kaposi Sarcoma 25942495 disease of cellular proliferation DOID:8632 C46 D012514 our data provide a more detailed understanding of KSHV latency and guide further studies of the biological significance of these changes. other hsa-mir-708 Kaposi Sarcoma 25942495 disease of cellular proliferation DOID:8632 C46 D012514 our data provide a more detailed understanding of KSHV latency and guide further studies of the biological significance of these changes. other hsa-mir-196a-1 Keloid 22358059 L91.0 D007627 148100 HP:0010562 miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts. other hsa-mir-196a-2 Keloid 22358059 L91.0 D007627 148100 HP:0010562 miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts. other hsa-mir-205 Keloid 27651436 L91.0 D007627 148100 HP:0010562 Upregulation of microRNA-205 suppresses vascular endothelial growth factor expression-mediated PI3K/Akt signaling transduction in human keloid fibroblasts. other hsa-mir-146a Keratitis 24996260 nervous system disease DOID:4677 H16 D007634 148190 HP:0000491 Our data demonstrate that miR-146a controls nuclear factor kappa B-dependent inflammatory responses in keratinocytes and chronic skin inflammation in AD. other hsa-mir-155 Keratitis 25700796 nervous system disease DOID:4677 H16 D007634 148190 HP:0000491 Role of miR-155 in the pathogenesis of herpetic stromal keratitis. other hsa-mir-182 Keratitis 27035623 nervous system disease DOID:4677 H16 D007634 148190 HP:0000491 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. other hsa-mir-183 Keratitis 27035623 nervous system disease DOID:4677 H16 D007634 148190 HP:0000491 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. other hsa-mir-96 Keratitis 27035623 nervous system disease DOID:4677 H16 D007634 148190 HP:0000491 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. other hsa-mir-338 Kideny Transplant Rejection 25769569 T86.11 D006084 miR-338-5p is closely correlated with the procedure of renal allograft antibody-mediated rejection. other hsa-mir-107 Kidney Diseases [unspecific] 25392232 N18.9 D007674 new strategies for probing autonomic circulatory control and ultimately, susceptibility to hypertensive renal sequelae. other hsa-mir-107 Kidney Diseases [unspecific] 24597825 N18.9 D007674 This review was performed to sum up the role of miR-107 and its signaling pathways in renal diseases. other hsa-mir-155 Kidney Diseases [unspecific] 17965831 N18.9 D007674 miR-155 was shown to decrease the expression of angiotensin II type 1 receptor in human primary fibroblasts [175]. This suggests that miR-155 may regulate a diverse set of physiological functions including fluid homeostasis and renal function. other hsa-mir-192 Kidney Diseases [unspecific] 24508230 N18.9 D007674 miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. other hsa-mir-21 Kidney Diseases [unspecific] 24576069 N18.9 D007674 This review was performed to sum up the role of miR-21 and its signaling pathways in renal diseases. other hsa-mir-122 Kidney Injury 26489516 S37.0 D058186 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-151a Kidney Injury 26489516 S37.0 D058186 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-182 Kidney Injury 27870928 S37.0 D058186 miR-182-5p Inhibition Ameliorates Ischemic Acute Kidney Injury. other hsa-mir-200c Kidney Injury 27431456 S37.0 D058186 Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/渭l) and miR-423 (189 copies/渭L). other hsa-mir-21 Kidney Injury 25145934 S37.0 D058186 MicroRNA-21 in glomerular injury. other hsa-mir-382 Kidney Injury 26489516 S37.0 D058186 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-423 Kidney Injury 27431456 S37.0 D058186 Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/渭l) and miR-423 (189 copies/渭L). other hsa-mir-1236 Kidney Neoplasms 26481573 disease of cellular proliferation DOID:263 C64 D007680 Kidney cancer: RNA activation in RCC: p21 and miR-1236 are a promising pair. other hsa-mir-141 Kidney Neoplasms 27358122 disease of cellular proliferation DOID:263 C64 D007680 Invasion and metastasis ability of renal cancer cell strains 786-0: under the influence of miR-141. other hsa-mir-148b Kidney Neoplasms 26573018 disease of cellular proliferation DOID:263 C64 D007680 The present study therefore suggested that miR-148b exerts an oncogenic function by enhancing the proliferation and apoptosis of renal cancer cells by inhibiting the MAPK/JNK pathway. other hsa-mir-199a Kidney Neoplasms 24609899 disease of cellular proliferation DOID:263 C64 D007680 miR-199a-3p inhibits hepatocyte growth factor/c-Met signaling in renal cancer carcinoma. other hsa-mir-21 Kidney Neoplasms 22347428 disease of cellular proliferation DOID:263 C64 D007680 Up-Regulation of MicroRNA-21 Correlates with Lower Kidney Cancer Survival. other hsa-mir-21 Kidney Neoplasms 23981302 disease of cellular proliferation DOID:263 C64 D007680 NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation. other hsa-mir-27a Kidney Neoplasms 24173369 disease of cellular proliferation DOID:263 C64 D007680 Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. other hsa-mir-302 Kidney Neoplasms 26363379 disease of cellular proliferation DOID:263 C64 D007680 Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. other hsa-mir-367 Kidney Neoplasms 26363379 disease of cellular proliferation DOID:263 C64 D007680 Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. other hsa-mir-381 Kidney Neoplasms 23816136 disease of cellular proliferation DOID:263 C64 D007680 miR-381 increases sensitivity of 786-O cells to 5-FU by inhibitory WEE1 and increase of Cdc2 activity. other hsa-let-7a Laryngeal Neoplasms 19787239 C32.3 D007822 Thus, we propose that let-7a may be a tumor suppressor in laryngeal cancer by inhibiting cell growth, inducing cell apoptosis and downregulating the oncogenes expression. other hsa-mir-15a Laryngeal Neoplasms 29085504 C32.3 D007822 Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. other hsa-mir-193b Laryngeal Neoplasms 25517434 C32.3 D007822 Culturing the IL-10(+) Mos with effector CD8(+) T cells resulted in the suppression of CD8(+) T-cell activitie other hsa-mir-373 Laryngeal Neoplasms 26688807 C32.3 D007822 Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. other hsa-mir-152 Leiomyosarcoma 27900663 C55 D007890 HP:0100243 miR-152 down-regulation is associated with MET up-regulation in leiomyosarcoma and undifferentiated pleomorphic sarcoma. other hsa-mir-210 Leishmaniasis 24098824 disease by infectious agent DOID:9065 B55 D007896 602068 MicroRNA expression profile in human macrophages in response to Leishmania major infection. other hsa-mir-21 Lepromatous Leprosy 23134990 disease by infectious agent DOID:10887 A30.5 D015440 miR-21 and STAT3 are increased in LL lesions with PEH, given their association with epithelial hyperproliferation; and Cbl-b is diminished in LL lesions with PEH compared to classic LL lesions. other hsa-mir-17 Lesch-Nyhan Syndrome 23804752 disease of metabolism DOID:1919 E79.1 D007926 300322 Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome. other hsa-mir-1224 Leukemia 28977780 C95 D007938 613065 HP:0001909 a similar expression pattern of hsa-miR-1224-3p and hsa-miR-21 were observed in urine samples collected from human leukemia patients preconditioned with TBI other hsa-mir-125 Leukemia 22504525 C95 D007938 613065 HP:0001909 Here we discuss new findings concerning PU.1-controlled microRNAs and miR-125-regulated networks in normal and malignant myelopoiesis. other hsa-mir-125a Leukemia 24216483 C95 D007938 613065 HP:0001909 ASXL1-MT resulted in derepression of homeobox A9 (Hoxa9) and microRNA-125a (miR-125a) expression through inhibition of polycomb repressive complex 2–mediated (PRC2-mediated) methylation of histone H3K27. other hsa-mir-125a Leukemia 28381182 C95 D007938 613065 HP:0001909 Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines. other hsa-mir-125b Leukemia 25915540 C95 D007938 613065 HP:0001909 The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. other hsa-mir-126 Leukemia 26859449 C95 D007938 613065 HP:0001909 miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells. other hsa-mir-128a Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-138-1 Leukemia 19896708 C95 D007938 613065 HP:0001909 miR-138:miR-138 might reverse multidrug resistance of leukemia cells other hsa-mir-138-2 Leukemia 19896708 C95 D007938 613065 HP:0001909 miR-138:miR-138 might reverse multidrug resistance of leukemia cells other hsa-mir-145 Leukemia 20962326 C95 D007938 613065 HP:0001909 As evidence that this subset of miRNAs is relevant to leukemia, we show that loss of 2 miRNAs identified in our analysis, miR-145 and miR-146a, results in leukemia in a mouse model. other hsa-mir-145 Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-146 Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-146a Leukemia 26487345 C95 D007938 613065 HP:0001909 Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell. other hsa-mir-146a Leukemia 18568019 C95 D007938 613065 HP:0001909 In leukaemic cell lines PLZF overexpression downmodulated miR-146a and upregulated CXCR4 protein, whereas PLZF knockdown induced the opposite effects. other hsa-mir-146a Leukemia 20962326 C95 D007938 613065 HP:0001909 As evidence that this subset of miRNAs is relevant to leukemia, we show that loss of 2 miRNAs identified in our analysis, miR-145 and miR-146a, results in leukemia in a mouse model. other hsa-mir-150 Leukemia 17923094 C95 D007938 613065 HP:0001909 Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. other hsa-mir-150 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-150 Leukemia 18667440 C95 D007938 613065 HP:0001909 Our findings suggest that c-Myb is an evolutionally conserved target of miR-150 and miR-150/c-Myb interaction is important for embryonic development and possibly oncogenesis. other hsa-mir-150 Leukemia 27899822 C95 D007938 613065 HP:0001909 miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways. other hsa-mir-155 Leukemia 26337206 C95 D007938 613065 HP:0001909 Altogether, these data implicate QKI in the pathophysiology of inflammation and oncogenesis where miR-155 is involved. other hsa-mir-155 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-155 Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-15a Leukemia 21838537 C95 D007938 613065 HP:0001909 These data indicate that miR-15a/16-1 plays an important role in the ATRA-induced differentiation of leukemic and primary AML cells. other hsa-mir-16 Leukemia 17683260 C95 D007938 613065 HP:0001909 several confirmed miRNA targets appear in our high-confidence set, such as the interactions between miR-92 and the signal transduction gene MAP2K4, as well as the relationship between miR-16 and BCL2, an anti-apoptotic gene which has been implicated in chronic lymphocytic leukemia. other hsa-mir-16 Leukemia 20839343 C95 D007938 613065 HP:0001909 The murine disease is linked to a genetic abnormality in microRNA mir-15a/16-1 locus, resulting in decreased mature miR-15a/16. other hsa-mir-17 Leukemia 26041742 C95 D007938 613065 HP:0001909 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. other hsa-mir-17 Leukemia 25130806 C95 D007938 613065 HP:0001909 Anti-leukemia mechanism of miR-17 and miR-20a silencing mediated by miRNA sponge. other hsa-mir-17 Leukemia 24872388 C95 D007938 613065 HP:0001909 Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. other hsa-mir-17 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-17 Leukemia 27123834 C95 D007938 613065 HP:0001909 Combinatorial treatment against miR-17-5p and miR-19a-3p of the miR-17-92 cluster dramatically reduces colony forming ability of MLL-fusion containing cell lines relative to non-MLL acute myeloid leukemia (AML) controls. other hsa-mir-17 Leukemia 28247308 C95 D007938 613065 HP:0001909 Differential Maturation of miR-17 ~ 92 Cluster Members in Human Cancer Cell Lines. other hsa-mir-18 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-181 Leukemia 23550642 C95 D007938 613065 HP:0001909 We also present observations based on analyzes of miR-181 family genes that indicate the potential functions of primary and/or precursor miRNAs in target recognition and explore the impact of these findings on target identification. other hsa-mir-181 Leukemia 28072759 C95 D007938 613065 HP:0001909 Induction of K562 Cell Apoptosis by As4S4 via Down-Regulating miR181. other hsa-mir-181a Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-181a-2 Leukemia 23393335 C95 D007938 613065 HP:0001909 MicroRNA 181a Influences the Expression of HMGB1 and CD4 in Acute Leukemias other hsa-mir-181b Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-18a Leukemia 27888798 C95 D007938 613065 HP:0001909 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. other hsa-mir-196a Leukemia 20570349 C95 D007938 613065 HP:0001909 our results identify miR-196a and miR-196b as ERG regulators and implicate a potential role for these miRNAs in acute leukemia. other hsa-mir-196b Leukemia 19188669 C95 D007938 613065 HP:0001909 miR-196b: MLL normally regulates expression of mir-196b other hsa-mir-196b Leukemia 25475721 C95 D007938 613065 HP:0001909 miRNA-196b may play an essential role in the development of MLL-associated leukemias through inhibiting cell differentiation and apoptosis, while promoting cell proliferation. other hsa-mir-196b Leukemia 20570349 C95 D007938 613065 HP:0001909 our results identify miR-196a and miR-196b as ERG regulators and implicate a potential role for these miRNAs in acute leukemia. other hsa-mir-199a-1 Leukemia 22285730 C95 D007938 613065 HP:0001909 Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. other hsa-mir-199a-2 Leukemia 22285730 C95 D007938 613065 HP:0001909 Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. other hsa-mir-19a Leukemia 26041742 C95 D007938 613065 HP:0001909 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. other hsa-mir-19a Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-19b-1 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-20 Leukemia 26487345 C95 D007938 613065 HP:0001909 Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell. other hsa-mir-20a Leukemia 25130806 C95 D007938 613065 HP:0001909 Anti-leukemia mechanism of miR-17 and miR-20a silencing mediated by miRNA sponge. other hsa-mir-20a Leukemia 24872388 C95 D007938 613065 HP:0001909 Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. other hsa-mir-20a Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-20a Leukemia 23114118 C95 D007938 613065 HP:0001909 It is concluded that the miR-20a sponge is constructed successfully, and Jurkat-S stable cell line is established, in which the expression of miR-20a is inhibited stably. other hsa-mir-20a Leukemia 27010069 C95 D007938 613065 HP:0001909 Mechanistic study further shows that induction of SIRP伪 protein in APL cells by ATO is mediated through suppression of c-Myc, resulting in reduction of three SIRP伪-targeting microRNAs: miR-17, miR-20a and miR-106a. other hsa-mir-20a Leukemia 27888798 C95 D007938 613065 HP:0001909 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. other hsa-mir-20a Leukemia 28247308 C95 D007938 613065 HP:0001909 Differential Maturation of miR-17 ~ 92 Cluster Members in Human Cancer Cell Lines. other hsa-mir-21 Leukemia 26294715 C95 D007938 613065 HP:0001909 In this issue of Blood, Junker et al delineate a novel signaling axis involving miR-21 and the tumor suppressor Pdcd4 that is essential for Notch-mediated induction of T-cell acute lymphoblastic leukemia (T-ALL). other hsa-mir-21 Leukemia 27895788 C95 D007938 613065 HP:0001909 Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia. other hsa-mir-21 Leukemia 27995885 C95 D007938 613065 HP:0001909 Targeted suppression of miRNA-21 inhibit K562 cells growth through PTEN-PI3K/AKT signaling pathway. other hsa-mir-21 Leukemia 28218044 C95 D007938 613065 HP:0001909 Leukemia microvesicles affect healthy hematopoietic stem cells. other hsa-mir-21 Leukemia 28977780 C95 D007938 613065 HP:0001909 a similar expression pattern of hsa-miR-1224-3p and hsa-miR-21 were observed in urine samples collected from human leukemia patients preconditioned with TBI other hsa-mir-217 Leukemia 24350829 C95 D007938 613065 HP:0001909 Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors. miR-#-5p,miR-#-3p other hsa-mir-221 Leukemia 29156756 C95 D007938 613065 HP:0001909 Increasing knowledge of biological changes, due to altered miRNA dynamics, is expected to have relevant translational implications for leukemia detection and treatment other hsa-mir-223 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-23a Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-26a Leukemia 21455993 C95 D007938 613065 HP:0001909 we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN) other hsa-mir-29a Leukemia 28218044 C95 D007938 613065 HP:0001909 Leukemia microvesicles affect healthy hematopoietic stem cells. other hsa-mir-376 Leukemia 26940843 C95 D007938 613065 HP:0001909 MIR376 as an important microRNA family for cancer formation and progression other hsa-mir-548f Leukemia 28698179 C95 D007938 613065 HP:0001909 A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis. other hsa-mir-9-1 Leukemia 23509296 C95 D007938 613065 HP:0001909 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis other hsa-mir-92 Leukemia 17683260 C95 D007938 613065 HP:0001909 several confirmed miRNA targets appear in our high-confidence set, such as the interactions between miR-92 and the signal transduction gene MAP2K4, as well as the relationship between miR-16 and BCL2, an anti-apoptotic gene which has been implicated in chronic lymphocytic leukemia. other hsa-mir-9-2 Leukemia 23509296 C95 D007938 613065 HP:0001909 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis other hsa-mir-92-1 Leukemia 18536574 C95 D007938 613065 HP:0001909 Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92). other hsa-mir-92a Leukemia 28247308 C95 D007938 613065 HP:0001909 Differential Maturation of miR-17 ~ 92 Cluster Members in Human Cancer Cell Lines. other hsa-mir-92a Leukemia 28358188 C95 D007938 613065 HP:0001909 Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor. other hsa-mir-9-3 Leukemia 23509296 C95 D007938 613065 HP:0001909 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis other hsa-mir-150 Leukemia, Acute 24086639 disease of cellular proliferation DOID:12603 C95.0 308960 HP:0002488 miR-150 promotes myeloid differentiation, a previously uncharacterized role for this miRNA, and that absent or low miR-150 expression contributes to blocked myeloid differentiation in acute leukemia cells. other hsa-mir-222 Leukemia, Acute 23522449 disease of cellular proliferation DOID:12603 C95.0 308960 HP:0002488 MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia other hsa-mir-142 Leukemia, B-Cell 12007417 C91.31 D015448 151430 A translocation that make MYC overexpression other hsa-mir-15a Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-16-1 Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-17 Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-17 Leukemia, B-Cell 17989227 C91.31 D015448 151430 the miR-17 cluster (8, 9) synergizes with MYC to induce B cell lymphoma. other hsa-mir-17 Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-18 Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-18a Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-19a Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-19a Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-19b Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-19b-1 Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-20a Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-20a Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-92a Leukemia, B-Cell 23551855 C91.31 D015448 151430 DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas. other hsa-mir-92a-1 Leukemia, B-Cell 17940623 C91.31 D015448 151430 These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1. other hsa-mir-29b Leukemia, Biphenotypic, Acute 27775550 disease of cellular proliferation DOID:9953 C95.0 D015456 HP:0005531 MicroRNA-29b mediates altered innate immune development in acute leukemia. other hsa-mir-126 Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-126 Leukemia, Lymphoblastic 27535859 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 Bioinformatics analysis of microRNA comprehensive regulatory network in B- cell acute lymphoblastic leukemia. other hsa-mir-128 Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-146b Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-17 Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-18 Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-191 Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-19a Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-19b-1 Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-20a Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-223 Leukemia, Lymphoblastic 23815897 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 Expression of microRNA-223 in lymphocytic leukemia cells and its action mechanism other hsa-mir-425 Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-509 Leukemia, Lymphoblastic 25368993 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia. other hsa-mir-629 Leukemia, Lymphoblastic 19760605 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions. other hsa-mir-92-1 Leukemia, Lymphoblastic 20855495 disease of cellular proliferation DOID:1037 C91.0 D007945 613065 NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92. other hsa-mir-100 Leukemia, Lymphoblastic, Acute 23915977 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. other hsa-mir-125b Leukemia, Lymphoblastic, Acute 23915977 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. other hsa-mir-146a Leukemia, Lymphoblastic, Acute 23888320 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report. other hsa-mir-149 Leukemia, Lymphoblastic, Acute 26725775 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia. other hsa-mir-150 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-15a Leukemia, Lymphoblastic, Acute 27281445 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 Prednisolone in concentration of 700 µM was significantly increased the expression of miR 16-1 and miR 15a after 24 h and 48 h treatment other hsa-mir-16 Leukemia, Lymphoblastic, Acute 27281445 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 Prednisolone in concentration of 700 µM was significantly increased the expression of miR 16-1 and miR 15a after 24 h and 48 h treatment other hsa-mir-17 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-18 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-181a Leukemia, Lymphoblastic, Acute 28184923 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia. other hsa-mir-18a Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-196a-2 Leukemia, Lymphoblastic, Acute 24291415 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 Hsa-miR-196a2 polymorphism increases the risk of acute lymphoblastic leukemia in Chinese children. other hsa-mir-19a Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-19b-1 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-20a Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-222 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-29a Leukemia, Lymphoblastic, Acute 26251039 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia. other hsa-mir-34a Leukemia, Lymphoblastic, Acute 27150988 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 Expression of miR-34a in Bone Marrow of Adult Acute Lymphoblastic Leukemia and Its Significance in Cell Drug Resistance. other hsa-mir-92-1 Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-92a Leukemia, Lymphoblastic, Acute 25796601 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease. other hsa-mir-99a Leukemia, Lymphoblastic, Acute 23915977 disease of cellular proliferation DOID:9952 C91.0 D054198 247640 HP:0006721 MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. other hsa-mir-323b Leukemia, Lymphoblastic, Acute, B-Cell 27649261 disease of cellular proliferation DOID:0060592 C91.0 613065 HP:0004812 MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia. other hsa-mir-196b Leukemia, Lymphoblastic, Acute, Childhood 20494936 disease of cellular proliferation DOID:0080144 C91.0 D054198 613065 Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia. other hsa-mir-210 Leukemia, Lymphoblastic, Acute, Childhood 24720529 disease of cellular proliferation DOID:0080144 C91.0 D054198 613065 Effect of microRNA-210 on prognosis and response to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia. other hsa-mir-146b Leukemia, Lymphoblastic, Acute, T-Cell 27550837 disease of cellular proliferation DOID:5602 C91.0 613065 HP:0006727 MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia. other hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell 23525797 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients other hsa-mir-107 Leukemia, Lymphocytic, Chronic, B-Cell 19692702 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 regulation of PLAG1 by miR-181a, miR-181b, miR-107, and miR-424 other hsa-mir-122 Leukemia, Lymphocytic, Chronic, B-Cell 24047131 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Four-way junction formation promoting ultrasensitive electrochemical detection of microRNA. other hsa-mir-146a Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-146b Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-148a Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-150 Leukemia, Lymphocytic, Chronic, B-Cell 25833959 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile. other hsa-mir-151a Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 24914134 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 25833959 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile. other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 23821659 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 24136167 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 24392455 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Hsa-miR-15a and Hsa-miR-16-1 expression is not related to proliferation centers abundance and other prognostic factors in chronic lymphocytic leukemia. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 24971479 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of miR-15/16 in CLL. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 16885332 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 The finding that essentially all indolent CLLs have lost miR-15a/miR-16-1 expression suggests that this event is the initiating event in the pathogenesis of the indolent form of CLL. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-15b Leukemia, Lymphocytic, Chronic, B-Cell 26324892 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 These results are the first, to our knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 24392455 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Hsa-miR-15a and Hsa-miR-16-1 expression is not related to proliferation centers abundance and other prognostic factors in chronic lymphocytic leukemia. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 24971479 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of miR-15/16 in CLL. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 16885332 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 The finding that essentially all indolent CLLs have lost miR-15a/miR-16-1 expression suggests that this event is the initiating event in the pathogenesis of the indolent form of CLL. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 26324892 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 These results are the first, to our knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia. other hsa-mir-17 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-196b Leukemia, Lymphocytic, Chronic, B-Cell 20549547 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-196b:Potential tumor suppressive function of miR-196b in B-cell lineage acute lymphoblastic leukemia other hsa-mir-22 Leukemia, Lymphocytic, Chronic, B-Cell 24825182 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation. other hsa-mir-223 Leukemia, Lymphocytic, Chronic, B-Cell 25833959 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile. other hsa-mir-223 Leukemia, Lymphocytic, Chronic, B-Cell 20862275 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-223:ZAP70, LPL, CLLU1, microRNA-29c and microRNA-223 were measured by real time PCR in a cohort of 170 patients other hsa-mir-29 Leukemia, Lymphocytic, Chronic, B-Cell 25833959 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile. other hsa-mir-29 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-29a Leukemia, Lymphocytic, Chronic, B-Cell 20566844 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-29:dysregulation of miR-29 can contribute to the pathogenesis of indolent B-CLL other hsa-mir-29b-1 Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-29c Leukemia, Lymphocytic, Chronic, B-Cell 25860243 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Our data identify biological characteristics associated with subset #4 patients, providing further evidence for the putative role of BCR in shaping the features of the tumor cells in CLL. other hsa-mir-29c Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-29c Leukemia, Lymphocytic, Chronic, B-Cell 20862275 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-29c:ZAP70, LPL, CLLU1, microRNA-29c and microRNA-223 were measured by real time PCR in a cohort of 170 patients other hsa-mir-34 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-497 Leukemia, Lymphocytic, Chronic, B-Cell 25860243 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Our data identify biological characteristics associated with subset #4 patients, providing further evidence for the putative role of BCR in shaping the features of the tumor cells in CLL. other hsa-mir-640 Leukemia, Lymphocytic, Chronic, B-Cell 19717645 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia other hsa-mir-650 Leukemia, Lymphocytic, Chronic, B-Cell 22234685 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. other hsa-mir-663b Leukemia, Lymphocytic, Chronic, B-Cell 26305332 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. other hsa-mir-708 Leukemia, Lymphocytic, Chronic, B-Cell 25704289 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia. other hsa-mir-92 Leukemia, Lymphocytic, Chronic, B-Cell 25886051 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Role of microRNA in chronic lymphocytic leukemia onset and progression. other hsa-mir-125b Leukemia, Lymphocytic, Chronic, B-Cell 28126961 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. other hsa-mir-146b Leukemia, Lymphocytic, Chronic, B-Cell 27431016 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib. other hsa-mir-15 Leukemia, Lymphocytic, Chronic, B-Cell 26010203 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7. other hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 28783166 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 21881595 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. other hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell 23608884 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. other hsa-mir-16 Leukemia, Lymphocytic, Chronic, B-Cell 26010203 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7. other hsa-mir-16 Leukemia, Lymphocytic, Chronic, B-Cell 21881595 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. other hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell 23608884 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. other hsa-mir-17 Leukemia, Lymphocytic, Chronic, B-Cell 27059597 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Interestingly, TLR1/2 triggering restored BCR functionality, likely breaching the anergic state, and this was accompanied by induction of the miR-17鈭?2 cluster other hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell 27431016 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib. other hsa-mir-22 Leukemia, Lymphocytic, Chronic, B-Cell 27431016 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib. other hsa-mir-222 Leukemia, Lymphocytic, Chronic, B-Cell 28824233 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Inhibition of MicroRNA miR-222 with LNA Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia other hsa-mir-26a Leukemia, Lymphocytic, Chronic, B-Cell 28783166 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model. other hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell 27431016 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib. other hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell 18818704 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. other hsa-mir-363 Leukemia, Lymphocytic, Chronic, B-Cell 27118451 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 Our results reveal an enrichment of specific cellular miRNAs including miR-363 within EVs derived from CD40/IL-4-stimulated CLL cells compared with parental cell miRNA content and control EVs from unstimulated CLL cells. other hsa-mir-532 Leukemia, Lymphocytic, Chronic, B-Cell 28126961 disease of cellular proliferation DOID:1040 C91.1 D015451 151400 HP:0005550 miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. other hsa-mir-126 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 29505034 C92.1 D015464 Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia other hsa-mir-155 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 26548770 C92.1 D015464 Analysis of microRNA and gene networks in human chronic myelogenous leukemia. other hsa-mir-21 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 26116834 C92.1 D015464 Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth:a possible role for exosomal disposal of miR-21. other hsa-mir-21 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 27050372 C92.1 D015464 Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 other hsa-mir-10 Leukemia, Myeloid 21455993 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 Our analysis identified a strong positive correlation between HOX-related genes and miR-10 and miR-20a. other hsa-mir-125b Leukemia, Myeloid 25006123 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias. other hsa-mir-125b-1 Leukemia, Myeloid 25316507 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 Myeloid neoplasm with translocation t(2;11)(p21;q23-24), elevated microRNA 125b-1, and JAK2 exon 12 mutation. other hsa-mir-130a Leukemia, Myeloid 21638198 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML (Chronic Myeloid Leukaemia). other hsa-mir-130b Leukemia, Myeloid 21638198 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML (Chronic Myeloid Leukaemia). other hsa-mir-139 Leukemia, Myeloid 26165837 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 miR-139-5p controls translation in myeloid leukemia through EIF4G2. other hsa-mir-188 Leukemia, Myeloid 25646775 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia. other hsa-mir-20a Leukemia, Myeloid 21455993 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 Our analysis identified a strong positive correlation between HOX-related genes and miR-10 and miR-20a. other hsa-mir-210 Leukemia, Myeloid 25579461 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 The suitability of the method for biological samples was tested by detecting microRNA-210 from transfected K562 cells. other hsa-mir-27b Leukemia, Myeloid 24378438 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 (6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. other hsa-mir-486 Leukemia, Myeloid 25533034 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 miR-486-5p cooperates with GATA1s in supporting the growth and survival, and the aberrant erythroid phenotype of the megakaryocytic leukemias of DS. other hsa-mir-92a Leukemia, Myeloid 26866730 disease of cellular proliferation DOID:8692 C92 D007951 HP:0012324 The human myeloid leukemia cell line K562 secretes exosomes containing a large amount of miR-92a that enhances angiogenesis under normoxic and hypoxic conditions. other hsa-let-7a-1 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7a-2 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7a-3 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7b Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7b:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7c Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7c:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7c Leukemia, Myeloid, Acute 22964640 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia. other hsa-let-7d Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7d:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7e Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7e:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7f-1 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7f:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7f-2 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7f:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7g Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7g:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7i Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-let-7i:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-mir-1 Leukemia, Myeloid, Acute 20842122 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Our data showed that EVI1 controls proliferation in AML through modulation of miR-1-2. This study contributes to further understand the transcriptional networks involving transcription factors and miRNAs in AML. other hsa-mir-1 Leukemia, Myeloid, Acute 28042875 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 the PI3K/mTOR dual inhibitor BEZ235 effectively chemosensitizes AML cells via increasing miR-1-3p and subsequently down-regulating BAG4, EDN1 and ABCB1 other hsa-mir-10 Leukemia, Myeloid, Acute 24596420 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML. other hsa-mir-125a Leukemia, Myeloid, Acute 28053194 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. other hsa-mir-125b Leukemia, Myeloid, Acute 28053194 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. other hsa-mir-125b-1 Leukemia, Myeloid, Acute 18936236 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-125b-1: Myeloid cell differentiation arrest by miR-125b-1 other hsa-mir-126 Leukemia, Myeloid, Acute 26832662 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. other hsa-mir-126 Leukemia, Myeloid, Acute 18832181 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-126: discriminate CBF, t(15;17), and MLL-rearrangement AMLs other hsa-mir-126 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-126:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-mir-128 Leukemia, Myeloid, Acute 24846063 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells. other hsa-mir-142 Leukemia, Myeloid, Acute 24858343 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. other hsa-mir-142 Leukemia, Myeloid, Acute 22493297 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. other hsa-mir-146a Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-146a Leukemia, Myeloid, Acute 29657293 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors other hsa-mir-146a Leukemia, Myeloid, Acute 28399410 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. other hsa-mir-146b Leukemia, Myeloid, Acute 29657293 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors other hsa-mir-155 Leukemia, Myeloid, Acute 25428263 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. other hsa-mir-155 Leukemia, Myeloid, Acute 24708856 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 This study provides evidence for an anti-leukaemic role for miR-155 in human FLT3-wildtype AML, by inducing cell apoptosis and myelomonocytic differentiation, which is in contrast to its previously hypothesized role as an oncogene. This highlights the complexity of gene regulation by microRNAs that may have tumour repressor or oncogenic effects depending on disease context or tissue type. other hsa-mir-155 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-155:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-mir-155 Leukemia, Myeloid, Acute 22681934 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. other hsa-mir-155 Leukemia, Myeloid, Acute 23497456 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia other hsa-mir-155 Leukemia, Myeloid, Acute 24263100 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The silencing of Ago2 impairs the D3-dependent miR-17-5p/20a/106a, miR-125b and miR-155 downregulation, the accumulation of their translational targets AML1, VDR and C/EBP尾 and monocytic cell differentiation. other hsa-mir-155 Leukemia, Myeloid, Acute 28432220 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. other hsa-mir-15a Leukemia, Myeloid, Acute 19883312 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-15a in BM ( p = 0.034) and miR-16 in PB ( p = 0.005) were differentially expressed between low-risk and high-risk groups other hsa-mir-15b Leukemia, Myeloid, Acute 22015065 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia. other hsa-mir-17 Leukemia, Myeloid, Acute 18832181 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-17-5p: discriminate CBF, t(15;17), and MLL-rearrangement AMLs other hsa-mir-17 Leukemia, Myeloid, Acute 24263100 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The silencing of Ago2 impairs the D3-dependent miR-17-5p/20a/106a, miR-125b and miR-155 downregulation, the accumulation of their translational targets AML1, VDR and C/EBP尾 and monocytic cell differentiation. other hsa-mir-17 Leukemia, Myeloid, Acute 26038136 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 CDK inhibitor SNS-032 can induce apoptosis of AML HL-60 cells, which is associated with the inhibition of MCL-1,C-MYC and JAK2/STAT3, and down-regulation of miR-17-92 family. other hsa-mir-182 Leukemia, Myeloid, Acute 28663557 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation. other hsa-mir-186 Leukemia, Myeloid, Acute 27012040 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia. other hsa-mir-191 Leukemia, Myeloid, Acute 24858343 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. other hsa-mir-196b Leukemia, Myeloid, Acute 26436590 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature. other hsa-mir-196b Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-196b Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-196b:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-mir-19a Leukemia, Myeloid, Acute 24349422 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b. other hsa-mir-19b Leukemia, Myeloid, Acute 24349422 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b. other hsa-mir-203 Leukemia, Myeloid, Acute 25428263 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. other hsa-mir-20a Leukemia, Myeloid, Acute 18832181 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-20a: discriminate CBF, t(15;17), and MLL-rearrangement AMLs other hsa-mir-20a Leukemia, Myeloid, Acute 23515710 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. other hsa-mir-21 Leukemia, Myeloid, Acute 25543261 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 deregulated miR-21 expression may contribute to disease pathogenesis in NPM1-mutated AMLs other hsa-mir-21 Leukemia, Myeloid, Acute 26344648 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 GRh2 may be an effective treatment for pediatric leukemia, and GRh2 may induce apoptosis of leukemia cells through miR-21-modulated suppression of Bcl-2. other hsa-mir-219-1 Leukemia, Myeloid, Acute 22015065 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia. other hsa-mir-219 Leukemia, Myeloid, Acute 22015065 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia. other hsa-mir-22 Leukemia, Myeloid, Acute 27617961 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. other hsa-mir-221 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-221:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-mir-222 Leukemia, Myeloid, Acute 19883312 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-222 ( p = 0.0023) and miR-181a ( p = 0.014) expression was higher in AML than in MDS other hsa-mir-223 Leukemia, Myeloid, Acute 25710580 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology. other hsa-mir-223 Leukemia, Myeloid, Acute 26163797 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. other hsa-mir-223 Leukemia, Myeloid, Acute 20029046 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Our study supports a molecular network involving miR-223, C/EBPalpha, and E2F1 as major components of the granulocyte differentiation program, which is deregulated in AML. other hsa-mir-224 Leukemia, Myeloid, Acute 18832181 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-224: discriminate CBF, t(15;17), and MLL-rearrangement AMLs other hsa-mir-25 Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-25 Leukemia, Myeloid, Acute 26744876 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Moreover, miR-155 level was positively associated with the white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and C-reaction protein (CRP) value in peripheral blood (PB), as well as miR-25/miR-196b expression levels. other hsa-mir-26a-1 Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-26a-1 Leukemia, Myeloid, Acute 21901171 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. other hsa-mir-26a-2 Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-26a-2 Leukemia, Myeloid, Acute 21901171 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. other hsa-mir-29a Leukemia, Myeloid, Acute 21880628 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-29a and miR-30c might contribute to the sensitivity to cytarabine other hsa-mir-29a Leukemia, Myeloid, Acute 22493297 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. other hsa-mir-29b-1 Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-29b-2 Leukemia, Myeloid, Acute 20110180 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-30 Leukemia, Myeloid, Acute 24199710 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients. other hsa-mir-30c-1 Leukemia, Myeloid, Acute 21880628 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-29a and miR-30c might contribute to the sensitivity to cytarabine other hsa-mir-30c-2 Leukemia, Myeloid, Acute 21880628 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-29a and miR-30c might contribute to the sensitivity to cytarabine other hsa-mir-335 Leukemia, Myeloid, Acute 26287405 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Our finding suggests that bone marrow miR-335 level may be used as a marker to predict the chemotherapy response and prognosis in adult AML patients. other hsa-mir-34a Leukemia, Myeloid, Acute 22810507 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Clinically, low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome. Notably, in TP53(unaltered) CK-AML, high miR-34a expression predicted for inferior overall survival (OS), whereas in TP53(biallelic altered) CK-AML, high miR-34a expression pointed to better OS. other hsa-mir-378 Leukemia, Myeloid, Acute 23582927 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Overexpression of miR-378 is frequent and may affect treatment outcomes in patients with acute myeloid leukemia. other hsa-mir-382 Leukemia, Myeloid, Acute 18832181 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-382: discriminate CBF, t(15;17), and MLL-rearrangement AMLs other hsa-mir-424 Leukemia, Myeloid, Acute 22681934 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. other hsa-mir-494 Leukemia, Myeloid, Acute 27696394 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. other hsa-mir-590 Leukemia, Myeloid, Acute 22015065 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia. other hsa-mir-628 Leukemia, Myeloid, Acute 22015065 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia. other hsa-mir-7 Leukemia, Myeloid, Acute 27784745 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality. other hsa-mir-9 Leukemia, Myeloid, Acute 25428263 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. other hsa-mir-9 Leukemia, Myeloid, Acute 24270738 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 miR-9 is a tumor suppressor in pediatric AML other hsa-mir-9 Leukemia, Myeloid, Acute 26464168 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 Expression of a passenger miR-9* predicts favorable outcome in adults with acute myeloid leukemia less than 60 years of age. other hsa-mir-9 Leukemia, Myeloid, Acute 27770540 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. other hsa-mir-9 Leukemia, Myeloid, Acute 28272704 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. other hsa-mir-98 Leukemia, Myeloid, Acute 20425795 disease of cellular proliferation DOID:9119 C92.0 D015470 HP:0004820 hsa-mir-98:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. other hsa-let-7 Leukemia, Myeloid, Chronic 27494666 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 ADAR1 restores expression of let-7 and efficiently kills LSCs, providing an innovative therapeutic target in CML. other hsa-mir-130a Leukemia, Myeloid, Chronic 26494558 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Functional studies of miR-130a on the inhibitory pathways of apoptosis in patients with chronic myeloid leukemia. other hsa-mir-130a Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-142 Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-144 Leukemia, Myeloid, Chronic 22842456 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. other hsa-mir-145 Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-146a Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-15a Leukemia, Myeloid, Chronic 24629639 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 We found that dasatinib (DAS) modulated miR-let-7d, miR-let-7e, miR-15a, miR-16, miR-21, miR-130a and miR-142-3p expressions while IM modulated miR-15a and miR-130a levels. miR-16, miR-130a and miR-145 expressions were modulated by nilotinib (NIL). other hsa-mir-21 Leukemia, Myeloid, Chronic 25964959 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 we demonstrate that in two CML cell lines exhibiting different biological characteristics, LQB-118 modulates NFκB subcellular localization, apparently independently of the AKT and MAPK pathways, partially inhibits proteasome activity, and alters the expression of microRNAs -9 and -21. other hsa-mir-21 Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-26a Leukemia, Myeloid, Chronic 27421670 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. other hsa-mir-30a Leukemia, Myeloid, Chronic 22617440 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 microRNA 30A promotes autophagy in response to cancer therapy. other hsa-mir-451a Leukemia, Myeloid, Chronic 21944890 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 miRNA-451 is a putative predictor marker of Imatinib therapy response in chronic myeloid leukemia. other hsa-mir-451a Leukemia, Myeloid, Chronic 22842456 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. other hsa-mir-451b Leukemia, Myeloid, Chronic 22842456 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. other hsa-mir-7 Leukemia, Myeloid, Chronic 28986256 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. other hsa-mir-9 Leukemia, Myeloid, Chronic 25964959 disease of cellular proliferation DOID:8552 C92.1 D015464 HP:0005506 we demonstrate that in two CML cell lines exhibiting different biological characteristics, LQB-118 modulates NFκB subcellular localization, apparently independently of the AKT and MAPK pathways, partially inhibits proteasome activity, and alters the expression of microRNAs -9 and -21. other hsa-mir-125b Leukemia, Promyelocytic, Acute 27613090 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation. other hsa-mir-125b-1 Leukemia, Promyelocytic, Acute 21880154 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. other hsa-mir-142 Leukemia, Promyelocytic, Acute 27480083 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports ATRA-induced differentiation in APL-derived cells other hsa-mir-223 Leukemia, Promyelocytic, Acute 17217039 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 The activation of both pathways of transcriptional regulation by the myeloid lineage-specific transcription factor C/EBPalpha (CCAAT/enhancer-binding protein-alpha), and posttranscriptional regulation by miR-223 appears essential for granulocytic differentiation and clinical response of acute promyelocytic leukemia (APL) blasts to all-trans retinoic acid (ATRA). other hsa-mir-34a Leukemia, Promyelocytic, Acute 19151778 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation other hsa-mir-34b Leukemia, Promyelocytic, Acute 19151778 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation other hsa-mir-34c Leukemia, Promyelocytic, Acute 19151778 disease of cellular proliferation DOID:0060318 C92.4 D015473 612376 HP:0004836 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation other hsa-mir-28 Leukemia, T-Cell 25568327 disease of cellular proliferation DOID:715 C91.5 D015458 miR-28 may play an important role in HTLV-1 transmission. other hsa-mir-155 Leukemia-Lymphoma, Adult T-Cell 23762762 C91.51 D015459 HP:0005517 Cellular MicroRNA miR-155 has Important Roles in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. other hsa-mir-203 Leukemia-Lymphoma, Adult T-Cell 21865341 C91.51 D015459 HP:0005517 repressed other hsa-mir-205 Leukemia-Lymphoma, Adult T-Cell 21865341 C91.51 D015459 HP:0005517 repressed other hsa-mir-326 Leukemia-Lymphoma, Adult T-Cell 21865341 C91.51 D015459 HP:0005517 induced other hsa-mir-663a Leukemia-Lymphoma, Adult T-Cell 21865341 C91.51 D015459 HP:0005517 induced other hsa-mir-711 Leukemia-Lymphoma, Adult T-Cell 21865341 C91.51 D015459 HP:0005517 induced other hsa-mir-125b Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic 21738213 disease of cellular proliferation DOID:7061 C83.5 D015452 Our results provide direct evidence that miR-125b has important roles in the tumorigenesis of precursor B cells. other hsa-mir-146a Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 20110180 disease of cellular proliferation DOID:5599 C83.5 D054218 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-181a-2 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 20110180 disease of cellular proliferation DOID:5599 C83.5 D054218 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-181c Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 20110180 disease of cellular proliferation DOID:5599 C83.5 D054218 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-191 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 27093985 disease of cellular proliferation DOID:5599 C83.5 D054218 Expression of microRNA-191 in T lymphoblastic leukemia/lymphoma and its underlying mechanism. other hsa-mir-221 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 20110180 disease of cellular proliferation DOID:5599 C83.5 D054218 Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients, other hsa-mir-223 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 19148136 disease of cellular proliferation DOID:5599 C83.5 D054218 miR-223: regulated by Glucocorticoids (GCs) other hsa-mir-223 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 22424712 disease of cellular proliferation DOID:5599 C83.5 D054218 Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL. other hsa-mir-708 Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic 21926415 disease of cellular proliferation DOID:5599 C83.5 D054218 miR-708 was also found to be associated with the in vivo glucocorticoid therapy response and with disease risk stratification. other hsa-mir-122 Lipid Metabolism Disorder 17965831 disease of metabolism DOID:3146 E75 D008052 Inhibition of miR-122 resulted in decreased levels of cholesterol in the plasma and improved liver function in obese mice. other hsa-mir-122 Lipid Metabolism Disorder 20880716 disease of metabolism DOID:3146 E75 D008052 In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism. other hsa-mir-33 Lipid Metabolism Disorder 20880716 disease of metabolism DOID:3146 E75 D008052 In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism. other hsa-mir-33a Lipid Metabolism Disorder 25744742 disease of metabolism DOID:3146 E75 D008052 we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the thrifty aspect. other hsa-mir-33b Lipid Metabolism Disorder 25744742 disease of metabolism DOID:3146 E75 D008052 we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the thrifty aspect. other hsa-mir-370 Lipid Metabolism Disorder 20880716 disease of metabolism DOID:3146 E75 D008052 In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism. other hsa-mir-92a Lipid Metabolism Disorder 24481837 disease of metabolism DOID:3146 E75 D008052 MiR-92a: at the heart of lipid-driven endothelial dysfunction. other hsa-let-7b Liposarcoma 21412931 disease of cellular proliferation DOID:3382 C49.9 D008080 613488 HP:0012034 Let-7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. other hsa-let-7g Liposarcoma 21412931 disease of cellular proliferation DOID:3382 C49.9 D008080 613488 HP:0012034 Let-7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. other hsa-mir-143 Liposarcoma 21693658 disease of cellular proliferation DOID:3382 C49.9 D008080 613488 HP:0012034 microRNA-143 is a tumor suppressor activity in liposarcoma other hsa-mir-193b Liposarcoma 28882999 disease of cellular proliferation DOID:3382 C49.9 D008080 613488 HP:0012034 miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells. other hsa-let-7a Liver Cirrhosis 27115285 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 There was decreased expression of let-7a in BDL and Mdr2(-/-) cholangiocytes that was associated with increased NGF expression. other hsa-mir-106b Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-122 Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-122 Liver Cirrhosis 27391076 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment. other hsa-mir-181b Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-185 Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-18a Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-199a Liver Cirrhosis 22942713 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 This review provides a comprehensive survey of the literature on miR-199a as an example of the complexity of miRNA biology and suggests future directions for miRNA research. other hsa-mir-199a-1 Liver Cirrhosis 21283674 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis. other hsa-mir-199a-2 Liver Cirrhosis 21283674 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis. other hsa-mir-200a Liver Cirrhosis 21283674 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis. other hsa-mir-200a Liver Cirrhosis 28025657 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway. other hsa-mir-200b Liver Cirrhosis 21283674 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis. other hsa-mir-200b Liver Cirrhosis 28502477 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. other hsa-mir-203 Liver Cirrhosis 28355233 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. other hsa-mir-21 Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-21 Liver Cirrhosis 19203462 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 miR-21: n/a other hsa-mir-21 Liver Cirrhosis 26946098 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 increasing concentrations of Corilagin improved the quality of life, inhibited the mRNA expression of miR-21, promoted smad7 protein expression, and inhibited CTGF protein expression (p<0.05 or 0.01). other hsa-mir-219 Liver Cirrhosis 27855391 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Suppression of MicroRNA-219-5p Activates Keratinocyte Growth Factor to Mitigate Severity of Experimental Cirrhosis. other hsa-mir-219 Liver Cirrhosis 28355233 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. other hsa-mir-22 Liver Cirrhosis 26112332 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 MiR-22 promotes the development of cirrhosis through BMP7 suppression. other hsa-mir-221 Liver Cirrhosis 27935974 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis. other hsa-mir-29a Liver Cirrhosis 27480597 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 MiR-29a exhibited anti-fibrotic effect without cell toxicity in vivo and directly suppressed the expression of PDGF-related genes as well as COL1A1 and induced apoptosis of LX-2 cells. other hsa-mir-29c Liver Cirrhosis 26456479 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. other hsa-mir-34a Liver Cirrhosis 25068403 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 This study demonstrates for the first time, that miRNA-34a mayoriginate to a large extent from the liver. Even though higher levels ofmiRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better. other hsa-mir-92a Liver Cirrhosis 27246196 endocrine system disease DOID:5082 K74 D008103 215600 HP:0001394 miR-92a expression closely correlated with the frequency of a subset of IL-17-producing T helper cells (Th17) other hsa-mir-122 Liver Diseases [unspecific] 24354366 K76.9 D008107 Roadmap of miR-122-related clinical application from bench to bedside. other hsa-mir-122 Liver Diseases [unspecific] 26574140 K76.9 D008107 miR-122 increased with moderate ethanol consumption, but the fold change was modest. As increases with acetaminophen toxicity are 100- to 10000-fold, moderate ethanol intoxication is unlikely to confound the use of this biomarker of hepatotoxicity. other hsa-mir-122 Liver Diseases [unspecific] 24121065 K76.9 D008107 miR-122 is a liver-specific microRNA associated with many liver diseases other hsa-mir-122 Liver Diseases [unspecific] 26669080 K76.9 D008107 Biological function of miR-122 and its relationship with liver diseases. other hsa-mir-122 Liver Diseases [unspecific] 27391076 K76.9 D008107 we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment. other hsa-mir-146a Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-146b Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-152 Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-183 Liver Diseases [unspecific] 25963660 K76.9 D008107 These results indicate that the modulation of miRNA processing by COX-2 is a key event in insulin signaling in liver and has potential clinical implications for the management of various hepatic dysfunctions. other hsa-mir-19b Liver Diseases [unspecific] 28083843 K76.9 D008107 MicroRNA-19b Expression in Human Biliary Atresia Specimens and Its Role in BA-Related Fibrosis. other hsa-mir-200a Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-200b Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-200c Liver Diseases [unspecific] 25562147 K76.9 D008107 a critical role for miRNAs in the pathogenesis of NAFLD. other hsa-mir-21 Liver Diseases [unspecific] 27107786 K76.9 D008107 In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed other hsa-mir-214 Liver Diseases [unspecific] 28438567 K76.9 D008107 A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. other hsa-mir-27a Liver Diseases [unspecific] 25716995 K76.9 D008107 our study demonstrates the regulatory role of miR-27a in alcohol-induced monocyte activation and polarization. other hsa-mir-29a Liver Diseases [unspecific] 22469499 K76.9 D008107 Hepatic miR-29ab1 expression modulates chronic hepatic injury. other hsa-mir-29b-1 Liver Diseases [unspecific] 22469499 K76.9 D008107 Hepatic miR-29ab1 expression modulates chronic hepatic injury. other hsa-mir-29b-2 Liver Diseases [unspecific] 22469499 K76.9 D008107 Hepatic miR-29ab1 expression modulates chronic hepatic injury. other hsa-mir-34a Liver Diseases [unspecific] 29391755 K76.9 D008107 After normalization of the steatosis-related circRNA by expression vector, analysis of miR-34a activity, peroxisome proliferator-activated receptor (PPAR)α level, and expression of downstream genes were carried out so as to reveal its impact on the miR-34a/PPARα regulatory system other hsa-mir-942 Liver Diseases [unspecific] 28438567 K76.9 D008107 A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. other hsa-mir-223 Liver Failure 25562161 K72 D017093 613070 HP:0001399 miR-223 acted to inhibit IL-1β production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF. Thus, it played an important role in the pathogenesis of ALF. other hsa-mir-24 Liver Fibrosis 28602220 K74 D008103 Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice. other hsa-mir-33a Liver Fibrosis 24100264 K74 D008103 the expression of miR-33a increased with the progression of liver fibrosis. These results suggested that anti-miR-33a inhibit activation and extracellular matrix production, at least in part, via the activation of PI3K/Akt pathway and PPAR-α and anti sense of miR-33a may be a novel potential therapeutic approach for treating hepatic fibrosis in the future. other hsa-mir-122 Liver Injury 26489516 S36.11 D056486 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-122 Liver Injury 24118944 S36.11 D056486 M65 and microRNA-122 are potential biomarkers of DILI superior to ALT with respect to sensitivity and specificity. other hsa-mir-122 Liver Injury 25039534 S36.11 D056486 In mice and humans, miR-122 levels represent an independent and potent marker of ongoing liver injury and hepatic cell death regardless of the underlying disease. other hsa-mir-122 Liver Injury 28341748 S36.11 D056486 Drug-induced liver injury: recent advances in diagnosis and risk assessment. other hsa-mir-151a Liver Injury 26489516 S36.11 D056486 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-155 Liver Injury 26844784 S36.11 D056486 Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway. other hsa-mir-200a Liver Injury 25789565 S36.11 D056486 our data indicate that the p53-dependent expression of miR-200a-3p promotes cell death by inhibiting a p38/p53/miR-200 feedback loop. other hsa-mir-21 Liver Injury 29229992 S36.11 D056486 miRNA-21 ablation protects against liver injury and necroptosis in cholestasis other hsa-mir-223 Liver Injury 27679493 S36.11 D056486 MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. other hsa-mir-223 Liver Injury 28295449 S36.11 D056486 Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice. other hsa-mir-29 Liver Injury 24052410 S36.11 D056486 Our results indicate that miR-29a decreases cholestatic liver injury and fibrosis after BDL, at least partially, by modulating the extrinsic rather than intrinsic pathway of apoptosis. other hsa-mir-31 Liver Injury 25706292 S36.11 D056486 Both compounds also down-regulated miR-31, which directly targets caspase-2 and influences apoptosis in SEB-activated cells. other hsa-mir-382 Liver Injury 26489516 S36.11 D056486 In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury. other hsa-mir-877 Liver Injury 27713024 S36.11 D056486 MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury. other hsa-mir-101 Liver Neoplasms 24123132 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Another myc in the wall: microRNA-101 controls important functions in liver cancer formation. other hsa-mir-122 Liver Neoplasms 24386085 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. other hsa-mir-1307 Liver Neoplasms 26646011 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. other hsa-mir-142 Liver Neoplasms 25015418 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. other hsa-mir-143 Liver Neoplasms 29844837 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 The mechanism of miR-143 inducing apoptosis of liver carcinoma cells through regulation of the NF-κB pathway. other hsa-mir-199 Liver Neoplasms 24069256 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 We exploited this miR-199 differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, and achieve tumor-specific viral expression and replication. other hsa-mir-200a Liver Neoplasms 25203708 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 MiR-200a may play an important role in liver cancer development and may have diagnostic value for indicating early liver cancer. other hsa-mir-21 Liver Neoplasms 26646011 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. other hsa-mir-21 Liver Neoplasms 29091291 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Genetic and pharmacologic manipulation of miR-21 does not inhibit the development of liver fibrosis and liver cancer other hsa-mir-214 Liver Neoplasms 24386085 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. other hsa-mir-22 Liver Neoplasms 25596928 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 bile acid-activated FXR stimulates miR-22-silenced CCNA2, a novel pathway for FXR to exert its protective effect in the gastrointestinal tract. other hsa-mir-224 Liver Neoplasms 26646011 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. other hsa-mir-23a Liver Neoplasms 26439986 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 we found expression of miR-23a was related to p53 functional status in the male-derived liver cell-lines other hsa-mir-24 Liver Neoplasms 23382622 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. other hsa-mir-27 Liver Neoplasms 26646011 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. other hsa-mir-33 Liver Neoplasms 26646011 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. other hsa-mir-433 Liver Neoplasms 23979134 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein. other hsa-mir-612 Liver Neoplasms 24704424 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. other hsa-mir-629 Liver Neoplasms 23382622 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4α transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation. other hsa-let-7i Liver Neoplasms 21176238 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 let-7i* is overexpressed in side population of HCC cells compared to fetal liver cells other hsa-mir-122 Liver Neoplasms 20371461 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 miR-122, a major regulatory RNA in liver that fine-tunes the expression of over 100 cellular genes and enhances HCV replication other hsa-mir-124 Liver Neoplasms 22153071 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. other hsa-mir-200c Liver Neoplasms 24647918 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. other hsa-mir-24 Liver Neoplasms 22153071 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. other hsa-mir-27b Liver Neoplasms 25698578 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 we propose that miR-27b synergizes with anticancer drugs in a defined subgroup of liver and kidney cancer patients. other hsa-mir-629 Liver Neoplasms 22153071 disease of cellular proliferation DOID:916 C22.0 D008113 HP:0002896 we show that transient inhibition of HNF4α initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629. other hsa-mir-133a Long QT Syndrome 24809446 cardiovascular system disease DOID:2843 I45.81 D008133 192500 HP:0001657 MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome. other hsa-mir-210 Lung Disease [unspecific] 26079696 respiratory system disease DOID:850 J98.4 D008171 606963 this study demonstrates the added value of an integrated miRNA-mRNA approach for identifying molecular events altered by environmental pollutants in an in vitro human model. other hsa-let-7d Lung Fibrosis 28385811 respiratory system disease DOID:3770 J84.10 D011658 178500 Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model. other hsa-mir-153 Lung Fibrosis 26216407 respiratory system disease DOID:3770 J84.10 D011658 178500 These data suggest that miR-153 disturbs TGF-β1 signal transduction and its effects on fibroblast activation, acting as an anti-fibrotic element in the development of pulmonary fibrosis. other hsa-mir-154 Lung Fibrosis 28385811 respiratory system disease DOID:3770 J84.10 D011658 178500 Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model. other hsa-mir-200c Lung Fibrosis 28255128 respiratory system disease DOID:3770 J84.10 D011658 178500 Recent advances in miR-200c and fibrosis in organs. other hsa-mir-21 Lung Fibrosis 20643828 respiratory system disease DOID:3770 J84.10 D011658 178500 miR-21:These experiments demonstrate an important role for miR-21 in fibrotic lung diseases other hsa-mir-218 Lung Fibrosis 24298938 respiratory system disease DOID:3770 J84.10 D011658 178500 Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-218. other hsa-mir-29c Lung Fibrosis 28799781 respiratory system disease DOID:3770 J84.10 D011658 178500 MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis. other hsa-mir-31 Lung Fibrosis 22661007 respiratory system disease DOID:3770 J84.10 D011658 178500 miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. other hsa-mir-34a Lung Fibrosis 27635790 respiratory system disease DOID:3770 J84.10 D011658 178500 miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence. other hsa-mir-34a Lung Fibrosis 28273432 respiratory system disease DOID:3770 J84.10 D011658 178500 p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. other hsa-mir-486 Lung Fibrosis 26370615 respiratory system disease DOID:3770 J84.10 D011658 178500 The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis. other hsa-mir-223 Lung Injury [unspecific] 28931657 S27.309D D055370 Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. other hsa-let-7 Lung Neoplasms 24505620 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Mechanistic links between COPD and lung cancer: a role of microRNA let-7 other hsa-let-7 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-let-7a Lung Neoplasms 24293999 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. other hsa-let-7a Lung Neoplasms 26026830 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer. other hsa-let-7a Lung Neoplasms 26962302 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The present study reveals that decreased C/EBP伪 contributes to the down-regulation of miRNA let-7a-1 in lung cancer cells. other hsa-let-7a Lung Neoplasms 21097396 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Construction of let-7a expression plasmid and its inhibitory effect on k-Ras protein in A549 lung cancer cells other hsa-let-7a-1 Lung Neoplasms 20097187 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 inhibition of proliferation in non-small cell lung cancer other hsa-let-7a-1 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7a-2 Lung Neoplasms 20097187 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 inhibition of proliferation in non-small cell lung cancer other hsa-let-7a-2 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7a-3 Lung Neoplasms 20097187 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 inhibition of proliferation in non-small cell lung cancer other hsa-let-7a-3 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7b Lung Neoplasms 26026830 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer. other hsa-let-7b Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7c Lung Neoplasms 26026830 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer. other hsa-let-7c Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7c Lung Neoplasms 23880305 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Additionally, antrocin increased microRNA let-7c expression and suppressed STAT signaling. other hsa-let-7d Lung Neoplasms 26627242 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers. other hsa-let-7d Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7e Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7f Lung Neoplasms 26026830 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer. other hsa-let-7f-1 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7f-2 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7g Lung Neoplasms 21472347 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Precursor let-7g microRNA can supress A549 lung cancer cell migration. other hsa-let-7g Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-let-7i Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-mir-101 Lung Neoplasms 24958470 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 IL-1β-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. other hsa-mir-106a Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-106a Lung Neoplasms 19209007 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 High levels of miR-106a were associated with small-cell lung cancer (p = 0.031), and high levels of miR-19a with advanced NSCLC (p = 0.008). other hsa-mir-122 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-1226 Lung Neoplasms 25519225 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 the screening approach used in this study can identify clinically relevant synthetic lethal interactions and that vitamin D receptor agonists may show enhanced efficacy in p53-negative lung cancer patients. other hsa-mir-125a Lung Neoplasms 24044511 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells. other hsa-mir-125a Lung Neoplasms 19702827 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Taken together, our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor. other hsa-mir-125b Lung Neoplasms 25573191 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-125b may function as an oncogene in lung cancer. other hsa-mir-126 Lung Neoplasms 18602365 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-126: MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines other hsa-mir-126 Lung Neoplasms 19223090 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-126: inhibit the growth other hsa-mir-126 Lung Neoplasms 20097187 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 inhibition of proliferation in non-small cell lung cancer other hsa-mir-126 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-126 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-128b Lung Neoplasms 22352917 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Among them, 11 miRNAs including miR-7 and miR-128b were confirmed by published experimental data or literatures. other hsa-mir-1323 Lung Neoplasms 25823795 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells. other hsa-mir-133a Lung Neoplasms 24157646 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. other hsa-mir-133a-1 Lung Neoplasms 22089643 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. other hsa-mir-133b Lung Neoplasms 24157646 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. other hsa-mir-137 Lung Neoplasms 25498886 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-137 may be an independent favorable prognostic factor in NSCLC patients. other hsa-mir-138 Lung Neoplasms 24691972 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells. other hsa-mir-138 Lung Neoplasms 25994569 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells. other hsa-mir-141 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-145 Lung Neoplasms 20097187 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 inhibition of proliferation in non-small cell lung cancer other hsa-mir-146 Lung Neoplasms 23035181 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05). other hsa-mir-146a Lung Neoplasms 23555954 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells other hsa-mir-150 Lung Neoplasms 21935578 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Anti-miR-150 vector can regress A549 lung cancer tumors. other hsa-mir-153 Lung Neoplasms 25475731 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 significance of miR-153 and ADAM19 in the development and progression of NSCLC. other hsa-mir-154 Lung Neoplasms 25846246 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-154 suppresses non-small cell lung cancer growth in vitro and in vivo. other hsa-mir-155 Lung Neoplasms 25230125 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Chitosan combined with molecular beacon for mir-155 detection and imaging in lung cancer. other hsa-mir-155 Lung Neoplasms 26467212 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway. other hsa-mir-155 Lung Neoplasms 17965831 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer. other hsa-mir-155 Lung Neoplasms 21762626 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-155 could significantly inhibit the growth of human lung cancer 95D cells in vitro, which might be closely related to miR-155 induced G0/G1 phase arrest. other hsa-mir-155 Lung Neoplasms 24528019 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 As Hsa-miR-155 (miR-155) can be used as a diagnostic marker for non-small cell lung cancer (NSCLC), a smart molecular beacon of miR-155 was designed to image the expression of miR-155 in NSCLC cases. other hsa-mir-155 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-155 Lung Neoplasms 28315615 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. other hsa-mir-155 Lung Neoplasms 22796123 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The present study demonstrated that intracellular miR-155 could be successfully and quickly detected by novel miR-155 MBs. As a noninvasive monitoring approach, MBs could be used to diagnose lung cancer at early stage through molecular imaging. other hsa-mir-16 Lung Neoplasms 25912305 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16. other hsa-mir-17 Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-17 Lung Neoplasms 23263848 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-17-5p may be potential biomarker for prediction the prognosis in patients with lung cancer. other hsa-mir-17 Lung Neoplasms 23035181 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05). other hsa-mir-17 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-17 Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-18 Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-182 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-183 Lung Neoplasms 24586048 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells. other hsa-mir-183 Lung Neoplasms 25983004 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-183 promotes growth of non-small cell lung cancer cells through FoxO1 inhibition. other hsa-mir-183 Lung Neoplasms 18840437 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-183: a potential metastasis-inhibitor other hsa-mir-183 Lung Neoplasms 21503569 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. other hsa-mir-183 Lung Neoplasms 27593936 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation. other hsa-mir-185 Lung Neoplasms 19688090 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 cell cycle arrest other hsa-mir-18a Lung Neoplasms 19688090 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 cell cycle arrest other hsa-mir-18a Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-19 Lung Neoplasms 26098000 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition. other hsa-mir-191 Lung Neoplasms 25252218 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-191, by promoting the EMT and increasing CSC-like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells. other hsa-mir-192 Lung Neoplasms 28067164 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215 other hsa-mir-193a Lung Neoplasms 25391651 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation. other hsa-mir-196a Lung Neoplasms 27880728 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells. other hsa-mir-196a-2 Lung Neoplasms 19293314 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-196a-2: Susceptibility of Lung Cancer in Chinese other hsa-mir-197 Lung Neoplasms 25451482 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 ER stress plays a major role in STAT6-induced apoptosis. other hsa-mir-197 Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-19a Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-19b Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-19b-1 Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-200 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-200b Lung Neoplasms 26012256 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signaling and switching on miR-200b. other hsa-mir-200b Lung Neoplasms 21954225 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Stably expressing microRNA-200b in As-p53lowHBECs (human bronchial epithelial cell) abolished Akt and Erk1/2 activation, and completely suppressed cell migration and invasion. other hsa-mir-200c Lung Neoplasms 23824089 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract. other hsa-mir-200c Lung Neoplasms 24791940 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer. other hsa-mir-200c Lung Neoplasms 24468793 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Recent studies suggest that epithelial-mesenchymal transition (EMT) is the most important contributor to cancer metastasis. Induction of this complex process requires endogenously produced microRNAs; specifically, downregulation of the miRNA-200c causes an induction of EMT. other hsa-mir-200c Lung Neoplasms 28675952 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A novel fine tuning scheme of miR-200c in modulating lung cell redox homeostasis. other hsa-mir-205 Lung Neoplasms 24434435 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 We have demonstrated for the first time a new molecular pathway that connects TMPRSS4 and integrin α5 through miR-205 to regulate cancer cell invasion and metastasis. other hsa-mir-205 Lung Neoplasms 25695220 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. other hsa-mir-205 Lung Neoplasms 26001155 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reply to MiR-205 and miR-375 microRNA Assays to Distinguish Squamous Cell Carcinoma From Adenocarcinoma in Lung Cancer Biopsies. other hsa-mir-205 Lung Neoplasms 19273703 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-205: hsa-miR-205 as a highly specific marker for squamous cell lung carcinoma other hsa-mir-205 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-205 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-206 Lung Neoplasms 24390363 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Quantitative proteomics and protein network analysis of A549 lung cancer cells affected by miR-206. other hsa-mir-206 Lung Neoplasms 26075299 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Comprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis. other hsa-mir-206 Lung Neoplasms 21157919 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-206 Is Associated With Invasion and Metastasis of Lung Cancer. other hsa-mir-20a Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-21 Lung Neoplasms 23857284 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Expression and significance of miRNA-21 and BTG2 in lung cancer. other hsa-mir-21 Lung Neoplasms 24012885 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesis. other hsa-mir-21 Lung Neoplasms 25323306 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells. other hsa-mir-21 Lung Neoplasms 25831148 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer. other hsa-mir-21 Lung Neoplasms 25901472 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The present study reports that DEPs increased miR-21 expression and then activated the PTEN/PI3K/AKT pathway in human bronchial epithelial (HBE) cells, which may serve as an important carcinogenic mechanism. However, the data revealed that short-term exposure to a high DEP concentration did not cause evident cell carcinogenesis in HBE cells. other hsa-mir-21 Lung Neoplasms 26026961 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. other hsa-mir-21 Lung Neoplasms 26134223 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A prognostic classifier comprising three types of genomic and epigenomic data may help guide the postoperative management of stage I lung cancer patients at high risk of recurrence. other hsa-mir-21 Lung Neoplasms 26525579 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results, demonstrating the function of exosomal miR-21 from transformed HBE cells, provide a new perspective for intervention strategies to prevent carcinogenesis of lung cancer. other hsa-mir-21 Lung Neoplasms 27266356 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The effect and mechanism of microRNA-21 on cis-dichlorodiamineplatinum resistance in lung cancer cell strain. other hsa-mir-21 Lung Neoplasms 22866162 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The detection of miR-21 expression yielded 78.80% sensitivity and 100.00% specificity in the diagnosis of lung cancer. other hsa-mir-21 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-21 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155. other hsa-mir-21 Lung Neoplasms 28067164 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215 other hsa-mir-210 Lung Neoplasms 23492775 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines other hsa-mir-215 Lung Neoplasms 28067164 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215 other hsa-mir-217 Lung Neoplasms 25234467 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-217 functions as a tumour suppressor gene and correlates with cell resistance to cisplatin in lung cancer. other hsa-mir-218 Lung Neoplasms 26553452 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Our findings revealed an integrative tumor suppressor function of miR-218 in lung carcinogenesis and metastasis. other hsa-mir-221 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-222 Lung Neoplasms 23974492 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Metformin inhibits lung cancer cells proliferation through repressing microRNA-222. other hsa-mir-222 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-26 Lung Neoplasms 23035181 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05). other hsa-mir-26a Lung Neoplasms 24788552 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-26a involved in Toll-like receptor 9-mediated lung cancer growth and migration. other hsa-mir-27a Lung Neoplasms 27602162 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling. other hsa-mir-29 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-29b Lung Neoplasms 28164574 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Expression and Function Analysis of MicroRNA-29b in Xuanwei Lung Cancer. other hsa-mir-29b Lung Neoplasms 28869603 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 DNMT1 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression increases, whereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network other hsa-mir-30a Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155. other hsa-mir-30c Lung Neoplasms 25340791 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Specifically, miR-30c, a FHIT-upregulated microRNA, contributes to FHIT function in suppression of EMT and metastasis other hsa-mir-30d Lung Neoplasms 20194856 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival other hsa-mir-30d Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155. other hsa-mir-31 Lung Neoplasms 24978700 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis. other hsa-mir-31 Lung Neoplasms 22301433 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. other hsa-mir-31 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-31 Lung Neoplasms 28197369 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome. other hsa-mir-326 Lung Neoplasms 23142363 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis other hsa-mir-328 Lung Neoplasms 25646356 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. other hsa-mir-33a Lung Neoplasms 25544258 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 the treatment of lung cancer and clarify the mechanism of its progression. other hsa-mir-33a Lung Neoplasms 27593936 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation. other hsa-mir-34 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-346 Lung Neoplasms 24157646 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. other hsa-mir-34a Lung Neoplasms 24019906 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 the highly tumorigenic CD44(hi) cells are enriched for cells in the G2 phase of cell cycle. other hsa-mir-34a Lung Neoplasms 25909221 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). other hsa-mir-34a Lung Neoplasms 19736307 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 relevant to the diagnosis other hsa-mir-34a Lung Neoplasms 19921694 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-34a:MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells other hsa-mir-34a Lung Neoplasms 23036084 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 microRNA-34a Sensitizes Lung Cancer Cell Lines to DDP Treatment Independent of p53 Status. other hsa-mir-361 Lung Neoplasms 24157646 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. other hsa-mir-375 Lung Neoplasms 25695220 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. other hsa-mir-375 Lung Neoplasms 26001155 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Reply to MiR-205 and miR-375 microRNA Assays to Distinguish Squamous Cell Carcinoma From Adenocarcinoma in Lung Cancer Biopsies. other hsa-mir-378 Lung Neoplasms 25646356 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. other hsa-mir-4423 Lung Neoplasms 24191054 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 A primate-specific microRNA enters the lung cancer landscape. other hsa-mir-451 Lung Neoplasms 25150396 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-451 suppresses cell proliferation and metastasis in A549 lung cancer cells. other hsa-mir-486 Lung Neoplasms 23980150 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer. other hsa-mir-486 Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-486 Lung Neoplasms 20194856 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival other hsa-mir-486 Lung Neoplasms 28124991 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. other hsa-mir-487b Lung Neoplasms 23426183 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis other hsa-mir-494 Lung Neoplasms 25226615 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494. other hsa-mir-494 Lung Neoplasms 26040900 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer. other hsa-mir-494 Lung Neoplasms 22151897 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells. other hsa-mir-497 Lung Neoplasms 25909221 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). other hsa-mir-499a Lung Neoplasms 20194856 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival other hsa-mir-503 Lung Neoplasms 24398307 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MiR-503 was able to reverse the cisplatin resistance of A549/DDP.MiR-503 processed this kind of effect by inhibiting the drug efflux,downregulating the expression of drug-resistant related proteins and promoting cell apoptosis. other hsa-mir-522 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-5481 Lung Neoplasms 25245053 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results suggested that miR-548l may play a causal role through AKT1 in NSCLC invasion and metastasis. other hsa-mir-592 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-638 Lung Neoplasms 25952770 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy. other hsa-mir-660 Lung Neoplasms 28124991 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. other hsa-mir-7 Lung Neoplasms 26108539 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1. other hsa-mir-7 Lung Neoplasms 25910758 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 MicroRNA as tools and therapeutics in lung cancer. other hsa-mir-7 Lung Neoplasms 22352917 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Among them, 11 miRNAs including miR-7 and miR-128b were confirmed by published experimental data or literatures. other hsa-mir-720 Lung Neoplasms 25286763 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Evaluation of miR-720 prognostic significance in patients with colorectal cancer. other hsa-mir-768 Lung Neoplasms 23928793 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. other hsa-mir-769 Lung Neoplasms 26627242 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers. other hsa-mir-92 Lung Neoplasms 26156018 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. other hsa-mir-92-1 Lung Neoplasms 17384677 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth. other hsa-mir-92a Lung Neoplasms 25519225 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 the screening approach used in this study can identify clinically relevant synthetic lethal interactions and that vitamin D receptor agonists may show enhanced efficacy in p53-negative lung cancer patients. other hsa-mir-92a Lung Neoplasms 26451608 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. other hsa-mir-95 Lung Neoplasms 25831148 disease of cellular proliferation DOID:1324 C34.1-.3 D008175 HP:0100526 Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer. other hsa-mir-146a Lupus Vulgaris 19333922 A18.4 D008177 miR-146a: miR-146a contributes to abnormal activation of the type i interferon pathway in human lupus by targeting the key signaling proteins other hsa-let-7d Lymphoma 27300436 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 螖Np63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128 other hsa-mir-10b Lymphoma 27611973 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines. other hsa-mir-127 Lymphoma 26640803 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The result of cross validation indicates that MiRNAClassify significantly outperforms other methods and models. In addition, the newly added pre-miRNAs are used to further evaluate the ability of these methods to discover novel pre-miRNAs. MiRNAClassify still achieves consistently superior performance and can discover more pre-miRNAs. other hsa-mir-128 Lymphoma 27300436 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 螖Np63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128 other hsa-mir-143 Lymphoma 27611973 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines. other hsa-mir-146a Lymphoma 28918474 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Induction of Immunogenic Cell Death in Lymphoma Cells by Wharton's Jelly Mesenchymal Stem Cell Conditioned Medium. other hsa-mir-146a Lymphoma 21416002 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 In addition, LMP1 can also modulate cellular gene expression programs by affecting, via the NF-κB pathway, levels of cellular microRNAs miR-146a and miR-155 other hsa-mir-150 Lymphoma 21502955 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 microRNA-150 is a tumor suppressor in malignant lymphoma other hsa-mir-150 Lymphoma 24633319 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma. other hsa-mir-155 Lymphoma 22096245 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 miR-155 regulates HGAL expression and increases lymphoma cell motility. other hsa-mir-155 Lymphoma 22268450 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. other hsa-mir-155 Lymphoma 23815945 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Influence of miRNA-155 on lymphoma. other hsa-mir-155 Lymphoma 24345320 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Primary vitreoretinal B-cell lymphoma and uveitis might be characterized by distinct microRNA signatures. Quantification of ocular microRNA-155 might be helpful in the differential diagnosis of these 2 diseases. other hsa-mir-155 Lymphoma 25645925 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 miR-155 controls the outcome of the GC reaction by modulating its initiation (Aicda) and termination (Socs1/p53 response) other hsa-mir-155 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-155 Lymphoma 20133617 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects. other hsa-mir-155 Lymphoma 29228427 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 MiR-155 regulates lymphoma cell proliferation and apoptosis through targeting SOCS3/JAK-STAT3 signaling pathway other hsa-mir-155 Lymphoma 21416002 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 In addition, LMP1 can also modulate cellular gene expression programs by affecting, via the NF-κB pathway, levels of cellular microRNAs miR-146a and miR-155 other hsa-mir-15a Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-16 Lymphoma 23686310 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. other hsa-mir-16 Lymphoma 28976967 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis. other hsa-mir-16-1 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-17 Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-17 Lymphoma 19933089 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 miR-17-5p can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene other hsa-mir-17 Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-17 Lymphoma 16096373 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Herein, we propose a model in which the mir-17 cluster prevents excessive E2F1 activity, and thereby apoptosis, in response to activation of c-Myc. other hsa-mir-17 Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-17 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-17 Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-18 Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-18 Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-18 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-18 Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-181a Lymphoma 21525173 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS. other hsa-mir-18a Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-18a Lymphoma 19933089 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene other hsa-mir-18a Lymphoma 21525173 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS. other hsa-mir-18b Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-193b Lymphoma 23288923 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Interestingly, down-regulation of micro-RNAs mmu-miR-30a and mmu-miR-141 as well as hsa-miR-193b clearly contributes to enhance the expression of this gene in mouse and human lymphomas other hsa-mir-194 Lymphoma 26147452 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 modulation of microRNA-194 may constitute a novel approach to inhibiting proliferation of EBV(+) B cell lymphomas in PTLD. other hsa-mir-199a Lymphoma 26251897 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients. other hsa-mir-19a Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-19a Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-19a Lymphoma 19933089 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene other hsa-mir-19a Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-19a Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-19a Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-19b-1 Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-19b-1 Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-19b-1 Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-19b-1 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-19b-1 Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-19b-2 Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-200c Lymphoma 26639163 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. other hsa-mir-203 Lymphoma 26639163 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. other hsa-mir-20a Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-20a Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-20a Lymphoma 19933089 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene other hsa-mir-20a Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-20a Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-20a Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-20a Lymphoma 21114763 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The pro-senescence role of miR-20a and miR-290 in MEF is apparently in contrast with their proliferative role in tumour and ES cells. other hsa-mir-20b Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-21 Lymphoma 26116372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 MiR-21: an environmental driver of malignant melanoma other hsa-mir-21 Lymphoma 26150475 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. other hsa-mir-222 Lymphoma 21525173 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS. other hsa-mir-26a Lymphoma 23338972 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Our investigation of the mechanisms underlying the decrease in miR-26a in this lymphoma revealed novel evidence that STAT3, a major downstream substrate of NPM-ALK tyrosine kinase activity,suppresses MIR26A1 gene expression. other hsa-mir-26a Lymphoma 23538750 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Loss- or gain-of-function approaches revealed that miR-26a functioned as a tumor suppressor miRNA and mediated the combinatorial effects of JQ1 and DZNep. other hsa-mir-31 Lymphoma 26639163 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. other hsa-mir-497 Lymphoma 26251897 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients. other hsa-mir-92-1 Lymphoma 25870038 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. other hsa-mir-92-1 Lymphoma 17608773 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron. other hsa-mir-92-1 Lymphoma 17727326 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster). other hsa-mir-92-1 Lymphoma 18329372 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. other hsa-mir-92a-1 Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-92a-2 Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-92b Lymphoma 17093929 disease of cellular proliferation DOID:0060058 C85.9 D008223 HP:0002665 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. other hsa-mir-146a Lymphoma, B-Cell 25906746 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 Together our findings illuminate a bona fide role for miR-146a in the modulation of B-cell oncogenesis and reveal the importance of understanding microRNA function in a cell- and disease-specific context. other hsa-mir-155 Lymphoma, B-Cell 25541152 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 Importantly, the targeting of miRNAs (like use of anti-miR-155 or miR-34a mimic) could provide a novel therapeutic approach as evidenced by tumour regression in xenograft mouse models and initial promising data from clinical trials. other hsa-mir-17 Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-18 Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 93 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-19a Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-19a Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 94 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-19b-1 Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-19b-1 Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 95 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-19b-2 Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-20a Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 96 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-21 Lymphoma, B-Cell 20693987 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 miR-21:OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma other hsa-mir-21 Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-21 Lymphoma, B-Cell 23548551 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 Inhibition of miR-21 Induces Biological and Behavioral Alterations in Diffuse Large B-Cell Lymphoma other hsa-mir-29a Lymphoma, B-Cell 20086245 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 our results in primary MCL cells indicate that down-regulation of miR-29 could cooperate with cyclin D1 in MCL pathogenesis. Thus, our findings provide not only miRNA expression signature but also a novel prognostic marker and pathogenetic factor for this malignancy. other hsa-mir-34a Lymphoma, B-Cell 25541152 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 Importantly, the targeting of miRNAs (like use of anti-miR-155 or miR-34a mimic) could provide a novel therapeutic approach as evidenced by tumour regression in xenograft mouse models and initial promising data from clinical trials. other hsa-mir-92-1 Lymphoma, B-Cell 20008931 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 The miR-17 approximately 96 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) other hsa-mir-92a-1 Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-92a-2 Lymphoma, B-Cell 21200023 disease of cellular proliferation DOID:707 D016393 109565 HP:0012191 diffuse large B-cell lymphoma other hsa-mir-101 Lymphoma, Burkitt 24577510 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101. other hsa-mir-10a Lymphoma, Burkitt 28400759 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma. other hsa-mir-127 Lymphoma, Burkitt 22941339 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. other hsa-mir-142 Lymphoma, Burkitt 27796281 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Epstein-Barr Virus (EBV)-BamHI-A Rightward Transcript (BART)-6 and Cellular MicroRNA-142 Synergistically Compromise Immune Defense of Host Cells in EBV-Positive Burkitt Lymphoma. other hsa-mir-143 Lymphoma, Burkitt 24577510 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101. other hsa-mir-145 Lymphoma, Burkitt 24577510 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101. other hsa-mir-146a Lymphoma, Burkitt 18347435 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 induced by EBV-encoded latent membrane protein 1 (LMP1) other hsa-mir-155 Lymphoma, Burkitt 17965831 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer. other hsa-mir-155 Lymphoma, Burkitt 18347435 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 induced by EBV-encoded latent membrane protein 1 (LMP1) other hsa-mir-155 Lymphoma, Burkitt 18354490 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 process BIC other hsa-mir-155 Lymphoma, Burkitt 21831295 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 miR-93 repressed human activation induced cytidine deaminase. other hsa-mir-155 Lymphoma, Burkitt 17173072 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Our data provide evidence for two levels of regulation for mature miR-155 expression: one at the transcriptional level involving PKC and NF-kappaB, and one at the processing level. Burkitt lymphoma cells not only express low levels of BIC, but also prevent processing of BIC via an, as yet, unknown mechanism. other hsa-mir-15a Lymphoma, Burkitt 26893685 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs other hsa-mir-17 Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-18 Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-197 Lymphoma, Burkitt 28259992 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 EBV‑BART‑6‑3p and cellular microRNA‑197 compromise the immune defense of host cells in EBV‑positive Burkitt lymphoma. other hsa-mir-19a Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-19b-1 Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-20a Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-29a Lymphoma, Burkitt 25746661 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. other hsa-mir-29b Lymphoma, Burkitt 25746661 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. other hsa-mir-29c Lymphoma, Burkitt 25746661 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. other hsa-mir-34b Lymphoma, Burkitt 18802929 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 These results indicate for the first time that hsa-mir-34b may influence c-Myc expression in Burkitt lymphoma as the more common aberrant control exercised by the immunoglobulin enhancer locus. other hsa-mir-92-1 Lymphoma, Burkitt 17135268 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma. other hsa-mir-92a Lymphoma, Burkitt 27044389 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 Our results describe for the first time miR-17, miR-19a, miR-19b, miR-20a, and miR-92a expression profiles in pBL. other hsa-mir-93 Lymphoma, Burkitt 21831295 disease of cellular proliferation DOID:8584 C83.7 D002051 113970 HP:0030080 miR-93 repressed human activation induced cytidine deaminase. other hsa-mir-17 Lymphoma, Follicular 26997445 disease of cellular proliferation DOID:0050873 C82 D008224 613024 miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. other hsa-mir-31 Lymphoma, Follicular 26997445 disease of cellular proliferation DOID:0050873 C82 D008224 613024 miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. other hsa-mir-155 Lymphoma, Hodgkin 17965831 disease of cellular proliferation DOID:8567 C81 D006689 236000 HP:0012189 miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer. other hsa-mir-196a-1 Lymphoma, Hodgkin 24145479 disease of cellular proliferation DOID:8567 C81 D006689 236000 HP:0012189 MicroRNA and gene networks in human Hodgkin's lymphoma. other hsa-mir-9 Lymphoma, Hodgkin 26089393 disease of cellular proliferation DOID:8567 C81 D006689 236000 HP:0012189 We report a high-resolution time series study of transcriptome dynamics following antimiR-mediated inhibition of miR-9 in a Hodgkin lymphoma cell-line-the first such dynamic study of the microRNA inhibition response-revealing both general and specific aspects of the physiological response. other hsa-mir-9 Lymphoma, Hodgkin 24145479 disease of cellular proliferation DOID:8567 C81 D006689 236000 HP:0012189 MicroRNA and gene networks in human Hodgkin's lymphoma. other hsa-mir-1234 Lymphoma, Large B-Cell, Diffuse 23841503 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas. other hsa-mir-150 Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-155 Lymphoma, Large B-Cell, Diffuse 24989312 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 Role of miR-155 in pathogenesis of diffuse large B cell lymphoma and its possible mechanism other hsa-mir-155 Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-155 Lymphoma, Large B-Cell, Diffuse 22609116 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR-155 Regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. other hsa-mir-155 Lymphoma, Large B-Cell, Diffuse 28281962 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 MicroRNA-155 Downregulation Promotes Cell Cycle Arrest and Apoptosis in Diffuse Large B-Cell Lymphoma. other hsa-mir-155 Lymphoma, Large B-Cell, Diffuse 26523117 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas. other hsa-mir-18a Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-200 Lymphoma, Large B-Cell, Diffuse 24390222 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior. other hsa-mir-20a Lymphoma, Large B-Cell, Diffuse 29156774 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 MicroRNAs as predictors for CNS relapse of systemic diffuse large B-cell lymphoma other hsa-mir-221 Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-222 Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-342 Lymphoma, Large B-Cell, Diffuse 25866097 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. other hsa-mir-34a Lymphoma, Large B-Cell, Diffuse 22522790 disease of cellular proliferation DOID:0050745 C83.3 D016403 109565 Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. other hsa-mir-155 Lymphoma, Large-Cell, Anaplastic 25820993 disease of cellular proliferation DOID:0050744 C84.70 D017728 105590 HP:0012193 Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. other hsa-mir-17 Lymphoma, Large-Cell, Anaplastic 23975180 disease of cellular proliferation DOID:0050744 C84.70 D017728 105590 HP:0012193 The microRNA-17~92 cluster is involved in lymphomagenesis of STAT3(+) ALCL and that its inhibition might represent an alternative avenue to interfere with ALK signaling in anaplastic large cell lymphomas. other hsa-mir-15a Lymphoma, Mantle-Cell 22002311 C83.10 D020522 Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. other hsa-mir-16-1 Lymphoma, Mantle-Cell 22002311 C83.10 D020522 Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. other hsa-mir-20b Lymphoma, Mantle-Cell 20485376 C83.10 D020522 miR-20b:miR-20b, whose lack of expression distinguished cases with a survival probability of 56% at 60 months other hsa-mir-26a-1 Lymphoma, Mantle-Cell 20485376 C83.10 D020522 miR-26a:NF-kappaB subunit nuclear translocation to be regulated by the expression of miR-26a other hsa-mir-26a-2 Lymphoma, Mantle-Cell 20485376 C83.10 D020522 miR-26a:NF-kappaB subunit nuclear translocation to be regulated by the expression of miR-26a other hsa-let-7a Lymphoma, Non-Hodgkin 24648290 disease of cellular proliferation DOID:0060060 C85.9 D008228 605027 HP:0012539 Accordingly, c-Myc-targeting microRNAs let-7a and miR-26a were induced in all treated lymphomas and the cap-dependent translation machinery components 4E-BP1, eIF4E and eIF4G, as well as their upstream regulators, Akt and PIM kinases, were inhibited in function of the cell sensitivity to ITF2357, and, in turn, c-Myc downregulation. other hsa-mir-148b Lymphoma, Non-Hodgkin 22843616 disease of cellular proliferation DOID:0060060 C85.9 D008228 605027 HP:0012539 MicroRNA-148b enhances the radiosensitivity of non-Hodgkin's Lymphoma cells by promoting radiation-induced apoptosis. other hsa-mir-26a Lymphoma, Non-Hodgkin 24648290 disease of cellular proliferation DOID:0060060 C85.9 D008228 605027 HP:0012539 Accordingly, c-Myc-targeting microRNAs let-7a and miR-26a were induced in all treated lymphomas and the cap-dependent translation machinery components 4E-BP1, eIF4E and eIF4G, as well as their upstream regulators, Akt and PIM kinases, were inhibited in function of the cell sensitivity to ITF2357, and, in turn, c-Myc downregulation. other hsa-mir-26b Lymphoma, Non-Hodgkin 23978716 disease of cellular proliferation DOID:0060060 C85.9 D008228 605027 HP:0012539 Hepatitis C-associated B-cell non-Hodgkin lymphomas: the emerging role of miRNA-26b. other hsa-mir-126 Lymphoma, T-Cell, Cutaneous 24033365 disease of cellular proliferation DOID:0060061 C84.A0 D016410 608856 HP:0012192 Taken together, our findings suggest that both malignant and non-malignant T cells express miR-155 in situ in CTCL. Moreover, they indicate heterogeneity in miR-155 expression among malignant T cells. other hsa-mir-150 Lymphoma, T-Cell, Cutaneous 24627548 disease of cellular proliferation DOID:0060061 C84.A0 D016410 608856 HP:0012192 In this issue of Blood, Ito et al demonstrate pathogenic implications of microRNA-150 (miR-150) repression in an aggressive form of cutaneous T-cell lymphoma (CTCL). other hsa-mir-155 Lymphoma, T-Cell, Cutaneous 24033365 disease of cellular proliferation DOID:0060061 C84.A0 D016410 608856 HP:0012192 Taken together, our findings suggest that both malignant and non-malignant T cells express miR-155 in situ in CTCL. Moreover, they indicate heterogeneity in miR-155 expression among malignant T cells. other hsa-mir-21 Lymphoma, T-Cell, Cutaneous 27422033 disease of cellular proliferation DOID:0060061 C84.A0 D016410 608856 HP:0012192 Our findings not only demonstrate a critical role for IL15-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL involving IL15, HDAC1, HDAC6, and miR-21 that shows differential sensitivity to isotype-specific HDAC inhibitors. other hsa-mir-181a Machado-Joseph Disease 28236575 nervous system disease DOID:1440 G11.1 D017827 109150 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. other hsa-mir-494 Machado-Joseph Disease 28236575 nervous system disease DOID:1440 G11.1 D017827 109150 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. other hsa-mir-9 Machado-Joseph Disease 28236575 nervous system disease DOID:1440 G11.1 D017827 109150 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. other hsa-let-7 Malignant Neoplasms [unspecific] 26285684 C80.1 D009369 and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. other hsa-mir-125 Malignant Neoplasms [unspecific] 26731991 C80.1 D009369 These results suggest that different members of the miR-125 family may have different functions in various cancers. Furthermore, miR-125a or miR-125b may be important clinical prognostic biomarkers for cancer patients. other hsa-mir-126 Malignant Neoplasms [unspecific] 26351404 C80.1 D009369 Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers. other hsa-mir-15 Malignant Neoplasms [unspecific] 28032148 C80.1 D009369 The relationship between platinum drug resistance and epithelial-mesenchymal transition. other hsa-mir-186 Malignant Neoplasms [unspecific] 28032148 C80.1 D009369 The relationship between platinum drug resistance and epithelial-mesenchymal transition. other hsa-mir-200b Malignant Neoplasms [unspecific] 25644713 C80.1 D009369 YY1 acts as novel critical interface between epigenetic code and miRNAs machinery under chronic hypoxia in malignancy. other hsa-mir-200c Malignant Neoplasms [unspecific] 25644713 C80.1 D009369 YY1 acts as novel critical interface between epigenetic code and miRNAs machinery under chronic hypoxia in malignancy. other hsa-mir-205 Malignant Neoplasms [unspecific] 25613953 C80.1 D009369 miRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted. other hsa-mir-21 Malignant Neoplasms [unspecific] 26320972 C80.1 D009369 Toehold-mediated nonenzymatic amplification circuit on graphene oxide fluorescence switching platform for sensitive and homogeneous microRNA detection. other hsa-mir-21 Malignant Neoplasms [unspecific] 26285684 C80.1 D009369 and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. other hsa-mir-22 Malignant Neoplasms [unspecific] 28000852 C80.1 D009369 Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer other hsa-mir-27a Malignant Neoplasms [unspecific] 26285684 C80.1 D009369 and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. other hsa-mir-34a Malignant Neoplasms [unspecific] 24091633 C80.1 D009369 miR-34a can potentially be exploited for DNA damage-effecting therapies of malignancies. other hsa-mir-451 Malignant Neoplasms [unspecific] 26285684 C80.1 D009369 and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. other hsa-mir-1202 Mandibular Prognathism 26025627 M26.19 176700 Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated. other hsa-mir-629 Mandibular Prognathism 26025627 M26.19 176700 Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated. other hsa-mir-638 Mandibular Prognathism 26025627 M26.19 176700 Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated. other hsa-mir-125a Medulloblastoma 18973228 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-125a: promote growth arrest and apoptosis of MB cells other hsa-mir-17 Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-17: collaborates with the Sonic Hedgehog pathway other hsa-mir-17 Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-18 Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-182 Medulloblastoma 22134538 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma. other hsa-mir-18a Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-18a: collaborates with the Sonic Hedgehog pathway other hsa-mir-199b Medulloblastoma 19308264 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-199b-5p: MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma other hsa-mir-19a Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-19a: collaborates with the Sonic Hedgehog pathway other hsa-mir-19a Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-19b-1 Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-19b: collaborates with the Sonic Hedgehog pathway other hsa-mir-19b-1 Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-19b-2 Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-19b: collaborates with the Sonic Hedgehog pathway other hsa-mir-20a Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-20a: collaborates with the Sonic Hedgehog pathway other hsa-mir-20a Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-21 Medulloblastoma 21775132 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 MicroRNA-21 suppression impedes medulloblastoma cell migration. other hsa-mir-30a Medulloblastoma 21177782 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. other hsa-mir-30a Medulloblastoma 28757413 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Restoration of miR-30a expression inhibits growth, tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition. other hsa-mir-31 Medulloblastoma 24970811 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2. other hsa-mir-31 Medulloblastoma 29377269 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31 other hsa-mir-34a Medulloblastoma 25348795 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 MiR-34a deficiency accelerates medulloblastoma formation in vivo. other hsa-mir-367 Medulloblastoma 26250335 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-367 promotes proliferation and stem-like traits in medulloblastoma cells. other hsa-mir-9-1 Medulloblastoma 18973228 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-9: promote growth arrest and apoptosis of MB cells other hsa-mir-9-2 Medulloblastoma 18973228 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-9: promote growth arrest and apoptosis of MB cells other hsa-mir-92-1 Medulloblastoma 27600805 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members other hsa-mir-92a-1 Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-92a: collaborates with the Sonic Hedgehog pathway other hsa-mir-92a-2 Medulloblastoma 19196975 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-92a: collaborates with the Sonic Hedgehog pathway other hsa-mir-9-3 Medulloblastoma 18973228 disease of cellular proliferation DOID:0050902 C71.6 D008527 155255 HP:0002885 miR-9: promote growth arrest and apoptosis of MB cells other hsa-let-7 Melanoma 28482074 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The overexpression of Lin28B reduced mature let-7 microRNA expression in melanoma cell lines other hsa-let-7a Melanoma 26693896 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Aberrant activation of some known miRNAs, e.g. let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes other hsa-let-7a Melanoma 27063098 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes other hsa-let-7b Melanoma 25868368 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The concomitant inhibition of MMP-9 and MMP-13 affects prognosis and survival in skin melanoma. other hsa-let-7b Melanoma 21087605 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells. other hsa-let-7b Melanoma 26754091 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 EGCG up-regulated miRNA-let-7b expression through 67LR in melanoma cells. other hsa-let-7i Melanoma 27063098 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes other hsa-mir-106a Melanoma 23217102 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine. other hsa-mir-106b Melanoma 25361006 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein. other hsa-mir-124-1 Melanoma 23404119 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma other hsa-mir-124-2 Melanoma 23404119 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma other hsa-mir-124-3 Melanoma 23404119 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma other hsa-mir-125a Melanoma 28140520 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway. other hsa-mir-125b Melanoma 28614272 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Quantification of microRNA-21 and microRNA-125b in melanoma tissue. other hsa-mir-125b-1 Melanoma 20153427 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-125b:miRNA125b may be involved in the regulation of VDR expression and in the resistance against 1,25(OH)(2)D(3) in melanoma cells other hsa-mir-125b-1 Melanoma 22213330 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Treatment with 5-Aza, but not with TSA, reduced the expression of miR-125b in the 1,25(OH)(2)D(3)-responsive and -resistant melanoma cell lines and in the NHM. other hsa-mir-125b-2 Melanoma 20153427 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-125b:miRNA125b may be involved in the regulation of VDR expression and in the resistance against 1,25(OH)(2)D(3) in melanoma cells other hsa-mir-125b-2 Melanoma 22213330 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Treatment with 5-Aza, but not with TSA, reduced the expression of miR-125b in the 1,25(OH)(2)D(3)-responsive and -resistant melanoma cell lines and in the NHM. other hsa-mir-126 Melanoma 23217102 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine. other hsa-mir-1280 Melanoma 25195599 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Antitumor activity of miR-1280 in melanoma by regulation of Src. other hsa-mir-137 Melanoma 18316599 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. other hsa-mir-141 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-141 Melanoma 20957176 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members. other hsa-mir-141 Melanoma 27616325 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila. other hsa-mir-142 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-142 Melanoma 26763444 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma. other hsa-mir-144 Melanoma 29260980 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma other hsa-mir-146b Melanoma 26763444 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma. other hsa-mir-149 Melanoma 21896753 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 p53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3ж┿ resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. Although deficiency in miR-149* undermined survival of melanoma cells and inhibited melanoma growth in a mouse xenograft model, elevated expression of miR-149* was found in fresh human metastatic melanoma isolates, which was associated with decreased glycogen synthase kinase-3ж┿and increased Mcl-1. other hsa-mir-150 Melanoma 25054912 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury. other hsa-mir-150 Melanoma 26763444 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma. other hsa-mir-155 Melanoma 26176991 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer. other hsa-mir-155 Melanoma 26763444 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma. other hsa-mir-15a Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-15b Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-16 Melanoma 23217102 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine. other hsa-mir-16-1 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-16-2 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-17 Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-18 Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-181a Melanoma 29041990 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells. other hsa-mir-182 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-182 Melanoma 28412746 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. other hsa-mir-183 Melanoma 28412746 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. other hsa-mir-18b Melanoma 23365201 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression other hsa-mir-18b Melanoma 24303553 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Role of miR-18b/MDM2/p53 circuitry in melanoma progression. other hsa-mir-191 Melanoma 27063098 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes other hsa-mir-193b Melanoma 22665054 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Taken together, our study suggests that downregulation of miR-193b may contribute to increased STMN1 expression in melanoma, which consequently promotes migration and proliferation of tumor cells. other hsa-mir-194 Melanoma 27573550 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-194 is a negative regulator of GEF-H1 pathway in melanoma. other hsa-mir-196a-1 Melanoma 20480203 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-196a:MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma other hsa-mir-196a-2 Melanoma 20480203 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-196a:MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma other hsa-mir-199a Melanoma 26176991 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer. other hsa-mir-199a Melanoma 23217102 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine. other hsa-mir-199a-1 Melanoma 23162627 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Let-7b and microRNA-199a inhibit the proliferation of B16F10 melanoma cells other hsa-mir-199a-2 Melanoma 23162627 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Let-7b and microRNA-199a inhibit the proliferation of B16F10 melanoma cells other hsa-mir-19a Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-19b-1 Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-200a Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-200a Melanoma 20957176 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members. other hsa-mir-200b Melanoma 20957176 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members. other hsa-mir-200c Melanoma 20957176 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members. other hsa-mir-203 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-204 Melanoma 29523154 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-204 represents a relevant mechanism in melanoma, with potential prognostic value and its loss seems to act in the CDKN2A pathway, in cooperation with NRAS other hsa-mir-205 Melanoma 22890556 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-205 is a tumor suppressor microRNAin malignant melanoma. other hsa-mir-205 Melanoma 28614272 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Quantification of microRNA-21 and microRNA-125b in melanoma tissue. other hsa-mir-206 Melanoma 24289491 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D. other hsa-mir-20a Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-21 Melanoma 21940630 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-21 regulates the metastatic behavior of B16 melanoma cells. other hsa-mir-21 Melanoma 25868368 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The concomitant inhibition of MMP-9 and MMP-13 affects prognosis and survival in skin melanoma. other hsa-mir-21 Melanoma 29058784 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-21 antisense oligonucleotide improves the sensitivity of A375 human melanoma cell to Cisplatin other hsa-mir-210 Melanoma 22962263 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Our findings show how miR-210 induction links hypoxia to immune escape from CTL-mediated lysis, by providing a mechanistic understanding of how this miRNA mediates immunosuppression in oxygen-deprived regions of tumors where cancer stem-like cells and metastatic cellular behaviors are known to evolve. other hsa-mir-210 Melanoma 26536104 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 methyl sulfone decreased expression of the master regulator of hypoxia, HIF-1伪, and reduced levels of the glycolytic enzymes, PKM2, LDHA, GLUT1, the pro-angiogenic protein, VEGF, and the iron-sulfur metabolism molecules, miR-210 and transferrin, all of which promote metastasis. other hsa-mir-211 Melanoma 21435193 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. other hsa-mir-211 Melanoma 27548915 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Melanoma miRNA trafficking controls tumour primary niche formation. other hsa-mir-211 Melanoma 27571736 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211 other hsa-mir-214 Melanoma 26176991 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer. other hsa-mir-214 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-214 Melanoma 21593728 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-214 drives melanoma metastasis. other hsa-mir-218-1 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-218-2 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-221 Melanoma 20547861 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 microRNA-221:Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells other hsa-mir-221 Melanoma 25492219 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The hair shaft miR-221 levels were significantly higher in patients with MM than controls. other hsa-mir-221 Melanoma 24035906 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 we report the production of circular microRNA sponges against miR-21 or miR-221 in cell lines using the self-splicing permuted intron-exon sequences derived from T4 bacteriophage gene td. other hsa-mir-221 Melanoma 26693896 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Aberrant activation of some known miRNAs, e.g. let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes other hsa-mir-221 Melanoma 28936555 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Resveratrol suppresses melanoma by inhibiting NF-κB/miR-221 and inducing TFG expression. other hsa-mir-222 Melanoma 26338962 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-222 could function as a biomarker for the prediction of response to ipilimumab other hsa-mir-222 Melanoma 26912358 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 vesicles released by miR-222-overexpressing cells were able to transfer miR-222-dependent malignancy when taken-up by recipient primary melanomas. other hsa-mir-222 Melanoma 28858076 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 KIT and mir-222 might be key genomic contributors toward the clinical differences observed other hsa-mir-26b Melanoma 26872428 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation. other hsa-mir-27b Melanoma 22213330 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Treatment with 1,25(OH)(2)D(3) and/or epigenetic drugs (5-Aza, TSA) reduced the miR-27b expression in three out of four melanoma cell lines. other hsa-mir-27b Melanoma 20495621 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 we identified miRNAs that are up- and down-regulated in melanoma cells exposed to a hESC microenvironment, such as miR-302a and miR-27b, respectively. other hsa-mir-29b Melanoma 27852308 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Systems analysis identifies miR-29b regulation of invasiveness in melanoma. other hsa-mir-302a Melanoma 20495621 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 we identified miRNAs that are up- and down-regulated in melanoma cells exposed to a hESC microenvironment, such as miR-302a and miR-27b, respectively. other hsa-mir-31 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-320 Melanoma 27816966 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. other hsa-mir-340 Melanoma 25043973 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma. other hsa-mir-340 Melanoma 26554847 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 This is the first study showing the relationship between miR-340-5p and expression of ABCB5, a transmembrane transporter involved in drug resistance considered as a marker of melanoma stem-like cells. other hsa-mir-342 Melanoma 26763444 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma. other hsa-mir-34a Melanoma 22102694 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D. other hsa-mir-34a Melanoma 21051724 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. other hsa-mir-34a Melanoma 21541354 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-34a and miR-185 were further shown to inhibit the growth of melanoma xenografts when implanted in SCID-NOD mice. other hsa-mir-34a Melanoma 22198089 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Our preliminary study suggests that miR-34a, although having a role in late tumorigenesis, does not contribute to the inherited susceptibility to cutaneous melanoma. other hsa-mir-34a Melanoma 28759238 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Ternary Nanoparticles with a Sheddable Shell Efficiently Deliver MicroRNA-34a against CD44-Positive Melanoma. other hsa-mir-34b Melanoma 21949788 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Expression of miR-34b reduced cell invasion and motility rates of both WM1552C and A375, suggesting that the enhanced cell invasiveness and motility observed in metastatic melanoma cells may be related to their reduced expression of miR-34b. other hsa-mir-34b Melanoma 28194372 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication. other hsa-mir-34c Melanoma 22102694 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D. other hsa-mir-362 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-375 Melanoma 21723283 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Ectopic expression of miR-375 inhibited melanoma cell proliferation, invasion, and cell motility, and induced cell shape changes, strongly suggesting that miR-375 may have an important function in the development and progression of human melanomas. other hsa-mir-378 Melanoma 28513838 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The emerging role of NPNT in tissue injury repair and bone homeostasis. other hsa-mir-4286 Melanoma 28005927 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells. other hsa-mir-429 Melanoma 20957176 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members. other hsa-mir-451a Melanoma 25237911 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion. other hsa-mir-455 Melanoma 25686251 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. other hsa-mir-486 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-625 Melanoma 28129648 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 microRNA-625 inhibits tumorigenicity by suppressing proliferation, migration and invasion in malignant melanoma. other hsa-mir-650 Melanoma 21543894 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04). other hsa-mir-768 Melanoma 23770856 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma. other hsa-mir-9-1 Melanoma 22825752 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. other hsa-mir-9-2 Melanoma 22825752 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. other hsa-mir-92-1 Melanoma 24920276 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. other hsa-mir-92a Melanoma 27620505 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells. other hsa-mir-9-3 Melanoma 22825752 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. other hsa-mir-96 Melanoma 22927992 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. other hsa-mir-96 Melanoma 28412746 disease of cellular proliferation DOID:1909 C43.9 D008545 155601 HP:0002861 Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. other hsa-mir-200a Meningioma 19703647 disease of cellular proliferation DOID:3565 D32.9 D008579 607174 HP:0002858 Down-regulation Promotes Tumor Growth by reducing E-cadherin and Activating the Wnt/{beta} catenin Signaling Pathway other hsa-mir-200a Meningioma 24858044 disease of cellular proliferation DOID:3565 D32.9 D008579 607174 HP:0002858 miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo. other hsa-mir-200a Meningioma 19703993 disease of cellular proliferation DOID:3565 D32.9 D008579 607174 HP:0002858 This reveals a previously unrecognized signaling cascade involved in meningioma tumor development and highlights a novel molecular interaction between miR-200a and Wnt signaling, thereby providing insights into novel therapies for meningiomas. other hsa-mir-21 Meningioma 26242334 disease of cellular proliferation DOID:3565 D32.9 D008579 607174 HP:0002858 Increased miR-21 and nestin mRNA levels were found in anaplastic meningiomas, in which recurrence is common, and the role of miR-21 and Nestin in meningiomas therefore warrants further investigation. other hsa-mir-29c Meningioma 28327132 disease of cellular proliferation DOID:3565 D32.9 D008579 607174 HP:0002858 Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c. other hsa-mir-146a Meningitis 24442429 nervous system disease DOID:9471 G03 D008581 Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. other hsa-mir-204 Mesial Temporal Lobe Epilepsy 25410734 G40.209 D004833 608096 miR-204 and miR-218 are developmentally regulated in the hippocampus and may contribute to the molecular mechanisms underlying the pathogenesis of MTLE and HS. other hsa-mir-218 Mesial Temporal Lobe Epilepsy 25410734 G40.209 D004833 608096 miR-204 and miR-218 are developmentally regulated in the hippocampus and may contribute to the molecular mechanisms underlying the pathogenesis of MTLE and HS. other hsa-mir-1 Mesothelioma 23828229 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 miR-1 induces growth arrest and apoptosis in malignant mesothelioma. other hsa-mir-106a Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-143 Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-17 Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-205 Mesothelioma 21983934 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 our findings indicate that epithelial-mesenchymal transition has a significant part in the morphological features of malignant mesothelioma. In particular, miR-205 down-regulation correlated ignificantly with both a mesenchymal phenotype and a more aggressive behavior. other hsa-mir-21 Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-29a Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-30c-1 Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-30c-2 Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-30d Mesothelioma 28979837 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 miR-30d is related to asbestos exposure and inhibits migration and invasion in NCI-H2452 cells. other hsa-mir-30e Mesothelioma 19502386 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype other hsa-mir-31 Mesothelioma 28918032 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma. other hsa-mir-34b Mesothelioma 23155254 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells other hsa-mir-34c Mesothelioma 23155254 disease of cellular proliferation DOID:1790 C45.9 C562839 156240 HP:0100001 MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells other hsa-mir-103 Metabolic Syndrome 20886002 disease of metabolism DOID:14221 E88.81 D024821 605552 Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments. other hsa-mir-103 Metabolic Syndrome 22436747 disease of metabolism DOID:14221 E88.81 D024821 605552 Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. other hsa-mir-107 Metabolic Syndrome 22436747 disease of metabolism DOID:14221 E88.81 D024821 605552 Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. other hsa-mir-122 Metabolic Syndrome 22965541 disease of metabolism DOID:14221 E88.81 D024821 605552 These results suggest that proanthocyanidin treatment increased hepatic cholesterol efflux to produce new HDL particles by repressing miR-33, and it reduced lipogenesis by repressing miR-122. other hsa-mir-143 Metabolic Syndrome 20886002 disease of metabolism DOID:14221 E88.81 D024821 605552 Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments. other hsa-mir-143 Metabolic Syndrome 28088407 disease of metabolism DOID:14221 E88.81 D024821 605552 Far-off and close-up dry matter intake modulate indicators of immunometabolic adaptations to lactation in subcutaneous adipose tissue of pasture-based transition dairy cows. other hsa-mir-221 Metabolic Syndrome 20886002 disease of metabolism DOID:14221 E88.81 D024821 605552 Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments. other hsa-mir-222 Metabolic Syndrome 20886002 disease of metabolism DOID:14221 E88.81 D024821 605552 Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments. other hsa-mir-27b Metabolic Syndrome 22893262 disease of metabolism DOID:14221 E88.81 D024821 605552 we thus speculate that Rb1 may act though PPARγ to downregulate mir-27b gene transcription and mature miR-27b activity, which in turn promotes PPARγ expression and adipogenesis. other hsa-mir-33 Metabolic Syndrome 22965541 disease of metabolism DOID:14221 E88.81 D024821 605552 These results suggest that proanthocyanidin treatment increased hepatic cholesterol efflux to produce new HDL particles by repressing miR-33, and it reduced lipogenesis by repressing miR-122. other hsa-mir-33a Metabolic Syndrome 22436747 disease of metabolism DOID:14221 E88.81 D024821 605552 miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. other hsa-mir-33b Metabolic Syndrome 22436747 disease of metabolism DOID:14221 E88.81 D024821 605552 miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. other hsa-mir-34a Metabolic Syndrome 22436747 disease of metabolism DOID:14221 E88.81 D024821 605552 Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. other hsa-mir-9-1 Methylmalonic Acidemia 24390963 disease of metabolism DOID:14749 E71.120 C537358 309541 A Primary Study on Down-Regulated miR-9-1 and Its Biological Significances in Methylmalonic Acidemia. other hsa-mir-145 Microvascular Disease 23875242 The role of miR-145 in microvasculature. other hsa-mir-15a Mitochondrial Metabolism Disease 29322081 disease of metabolism DOID:700 E88.40 D028361 Data of expression status of miR-29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition other hsa-mir-210 Mitochondrial Metabolism Disease 29621777 disease of metabolism DOID:700 E88.40 D028361 Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function other hsa-mir-214 Mitochondrial Metabolism Disease 29322081 disease of metabolism DOID:700 E88.40 D028361 Data of expression status of miR-29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition other hsa-mir-30c Mitochondrial Metabolism Disease 28330939 disease of metabolism DOID:700 E88.40 D028361 Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission. other hsa-mir-33 Mitochondrial Metabolism Disease 26185207 disease of metabolism DOID:700 E88.40 D028361 Novel Role of miR-33 in Regulating of Mitochondrial Function. other hsa-let-7a Monocytic Leukemia 29599918 disease of cellular proliferation DOID:8527 C93.Z 151380 HP:0004845 FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis. other hsa-let-7b Monocytic Leukemia 29790117 disease of cellular proliferation DOID:8527 C93.Z 151380 HP:0004845 Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids. other hsa-mir-155 Monocytic Leukemia 29790117 disease of cellular proliferation DOID:8527 C93.Z 151380 HP:0004845 Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids. other hsa-let-7 Multiple Myeloma 25925570 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Our study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation. other hsa-let-7a Multiple Myeloma 28808676 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 a thymidine-kinase-deleted let-7a-regulated vaccinia virus was safe and effective for mice, warranting clinical trials in humans other hsa-mir-106b Multiple Myeloma 27647143 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in berberine-induced multiple myeloma cells. other hsa-mir-125a Multiple Myeloma 24819167 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells. other hsa-mir-125a Multiple Myeloma 26496024 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Members of the miR-99b/let-7e/miR-125a cluster, or of its paralog, upregulated in t(4;14), were connected with the specific transcription factors PBX1 and CEBPA and several target genes. other hsa-mir-125b-1 Multiple Myeloma 23759586 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. other hsa-mir-125b-2 Multiple Myeloma 23759586 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. other hsa-mir-1271 Multiple Myeloma 27959416 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway. other hsa-mir-130b Multiple Myeloma 21761344 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. other hsa-mir-135b Multiple Myeloma 24223191 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. other hsa-mir-135b Multiple Myeloma 28245421 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21 other hsa-mir-135b Multiple Myeloma 28316065 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Identification of key genes and construction of microRNA-mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis. other hsa-mir-145 Multiple Myeloma 25369735 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo. other hsa-mir-146a Multiple Myeloma 29333170 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a other hsa-mir-148a Multiple Myeloma 28316065 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Identification of key genes and construction of microRNA-mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis. other hsa-mir-15a Multiple Myeloma 21936961 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells. other hsa-mir-15a Multiple Myeloma 21534877 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression. other hsa-mir-15a Multiple Myeloma 22781767 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 BMSCs suppress the proliferation of myeloma cells and regulate the drug sensitivity of myeloma cells through the inhibited expression of miRNA-15a/-16. IL-6 plays a pivotal role in the occurrence of drug resistance. other hsa-mir-15a Multiple Myeloma 28245421 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21 other hsa-mir-16 Multiple Myeloma 22781767 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 BMSCs suppress the proliferation of myeloma cells and regulate the drug sensitivity of myeloma cells through the inhibited expression of miRNA-15a/-16. IL-6 plays a pivotal role in the occurrence of drug resistance. other hsa-mir-16-1 Multiple Myeloma 21936961 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells. other hsa-mir-17 Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-181a-1 Multiple Myeloma 21761344 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. other hsa-mir-181a-2 Multiple Myeloma 21761344 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. other hsa-mir-18a Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-192 Multiple Myeloma 20951946 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development other hsa-mir-194-1 Multiple Myeloma 20951946 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development other hsa-mir-194-2 Multiple Myeloma 20951946 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development other hsa-mir-19a Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-19b-1 Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-202 Multiple Myeloma 26689580 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-202 over-expression sensitized MM cells to bortezomib (Bort) but less to Thalidomide (Thal) and dexamethasone (Dex). other hsa-mir-20a Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-20a Multiple Myeloma 26032093 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Expressions of miR-181a and miR-20a in RPMI8226 cell line and their potential as biomarkers for multiple myeloma. other hsa-mir-20a Multiple Myeloma 27129167 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Moreover, nano-sized exosomes were isolated with significantly increasing internal RNAs and down-regulation of exosomal miR-16-5p, miR-15a-5p and miR-20a-5p, miR-17-5p was revealed in the patients resistant to Bz. other hsa-mir-21 Multiple Myeloma 20302778 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-21 acts as an oncogene and miR-30b a tumor suppressor gene in MM other hsa-mir-21 Multiple Myeloma 21718132 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Myeloma cell adhesion to bone marrow stromal cells confers drug resistance by microRNA-21 up-regulation. other hsa-mir-21 Multiple Myeloma 23247593 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Set9, NF-kB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells other hsa-mir-21 Multiple Myeloma 24981236 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 MicroRNA-21 and multiple myeloma: small molecule and big function. other hsa-mir-21 Multiple Myeloma 25656574 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling. other hsa-mir-21 Multiple Myeloma 17496199 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3. other hsa-mir-21 Multiple Myeloma 27494872 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-21 and miR-221/222 could negatively modulate drug sensitivity of MM cells. other hsa-mir-21 Multiple Myeloma 28245421 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21 other hsa-mir-21 Multiple Myeloma 29158801 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Gambogenic Acid Exerts Antitumor Activity in Hypoxic Multiple Myeloma Cells by Regulation of miR-21 other hsa-mir-21 Multiple Myeloma 29320977 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3 other hsa-mir-21 Multiple Myeloma 29333170 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a other hsa-mir-215 Multiple Myeloma 20951946 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development other hsa-mir-221 Multiple Myeloma 23479461 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma other hsa-mir-222 Multiple Myeloma 23479461 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma other hsa-mir-223 Multiple Myeloma 21401705 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Expression of CD19 and lack of miR-223 distinguish extramedullary plasmacytoma from multiple myeloma. other hsa-mir-24 Multiple Myeloma 23934711 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Contribution of microRNA 24-3p and Erk1/2 to interleukin-6 mediated plasma cell survival. other hsa-mir-25 Multiple Myeloma 27647143 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in berberine-induced multiple myeloma cells. other hsa-mir-29b Multiple Myeloma 24091729 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-29b is endowed with epigenetic activity and mediates previously unknown functions of bortezomib in MM cells. other hsa-mir-29b Multiple Myeloma 24189534 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-29b: a new demethylator in multiple myeloma. other hsa-mir-29b Multiple Myeloma 26718793 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 genistein could suppress the protein level of NF-魏B and promote the expression of miR-29b in U266 cells. other hsa-mir-29b Multiple Myeloma 27430753 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 Paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microRNA鈥?9b and matrix metalloproteinase鈥?. other hsa-mir-29b-1 Multiple Myeloma 23254643 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease other hsa-mir-29b-2 Multiple Myeloma 23254643 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease other hsa-mir-30b Multiple Myeloma 20302778 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-21 acts as an oncogene and miR-30b a tumor suppressor gene in MM other hsa-mir-34a Multiple Myeloma 24587182 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma. other hsa-mir-636 Multiple Myeloma 21761344 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines. other hsa-mir-92a-1 Multiple Myeloma 21664042 disease of cellular proliferation DOID:9538 D009101 254500 HP:0006775 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. other hsa-mir-122 Multiple Sclerosis 28411393 nervous system disease DOID:2377 G35 D009103 PS126200 Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis. other hsa-mir-126 Multiple Sclerosis 24598267 nervous system disease DOID:2377 G35 D009103 PS126200 Our findings provided deeper insight into the mode of action of natalizumab, with possible implications for understanding both the effects of natalizumab on MS activity and its specific adverse event profile. other hsa-mir-126 Multiple Sclerosis 28358058 nervous system disease DOID:2377 G35 D009103 PS126200 MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium. other hsa-mir-141 Multiple Sclerosis 25938517 nervous system disease DOID:2377 G35 D009103 PS126200 According to our results, miR-141 and miR-200a may be key miRNAs in progression of symptoms of MS through inducing differentiation of Th17 cells and inhibiting differentiation to Treg cells. Our data suggest that these miRNAs may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation. other hsa-mir-142 Multiple Sclerosis 25486582 nervous system disease DOID:2377 G35 D009103 PS126200 AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT. other hsa-mir-142 Multiple Sclerosis 28100738 nervous system disease DOID:2377 G35 D009103 PS126200 miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation. other hsa-mir-145 Multiple Sclerosis 27752929 nervous system disease DOID:2377 G35 D009103 PS126200 miR-145 and miR20a-5p Potentially Mediate Pleiotropic Effects of Interferon-Beta Through Mitogen-Activated Protein Kinase Signaling Pathway in Multiple Sclerosis Patients. other hsa-mir-155 Multiple Sclerosis 21908875 nervous system disease DOID:2377 G35 D009103 PS126200 Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05). other hsa-mir-155 Multiple Sclerosis 25486582 nervous system disease DOID:2377 G35 D009103 PS126200 AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT. other hsa-mir-16 Multiple Sclerosis 25486582 nervous system disease DOID:2377 G35 D009103 PS126200 AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT. other hsa-mir-16 Multiple Sclerosis 24898268 nervous system disease DOID:2377 G35 D009103 PS126200 Further evidence indicated that DIM treatment significantly upregulated several miRNAs (miR-200c, miR-146a, miR-16, miR-93, and miR-22) in brain CD4(+) T cells during EAE while suppressing their associated target genes. other hsa-mir-17 Multiple Sclerosis 20201009 nervous system disease DOID:2377 G35 D009103 PS126200 Specifically, miR-17-5p, which is involved in autoimmunity, is upregulated in CD4(+) cells from MS patients other hsa-mir-17 Multiple Sclerosis 24901013 nervous system disease DOID:2377 G35 D009103 PS126200 Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis. other hsa-mir-17 Multiple Sclerosis 27512057 nervous system disease DOID:2377 G35 D009103 PS126200 Here, we provide the first experimental evidence of JMRV miRNAs in vitro and demonstrate that one of these viral miRNAs can mimic the activity of the cellular miR-17/20/106 family. other hsa-mir-200a Multiple Sclerosis 25938517 nervous system disease DOID:2377 G35 D009103 PS126200 According to our results, miR-141 and miR-200a may be key miRNAs in progression of symptoms of MS through inducing differentiation of Th17 cells and inhibiting differentiation to Treg cells. Our data suggest that these miRNAs may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation. other hsa-mir-20a Multiple Sclerosis 27752929 nervous system disease DOID:2377 G35 D009103 PS126200 miR-145 and miR20a-5p Potentially Mediate Pleiotropic Effects of Interferon-Beta Through Mitogen-Activated Protein Kinase Signaling Pathway in Multiple Sclerosis Patients. other hsa-mir-214 Multiple Sclerosis 26563334 nervous system disease DOID:2377 G35 D009103 PS126200 Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect. other hsa-mir-223 Multiple Sclerosis 26305248 nervous system disease DOID:2377 G35 D009103 PS126200 Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity. other hsa-mir-27a Multiple Sclerosis 26563334 nervous system disease DOID:2377 G35 D009103 PS126200 Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect. other hsa-mir-29c Multiple Sclerosis 23946286 nervous system disease DOID:2377 G35 D009103 PS126200 MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis. other hsa-mir-30a Multiple Sclerosis 27581464 nervous system disease DOID:2377 G35 D009103 PS126200 Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation. other hsa-mir-326 Multiple Sclerosis 19838199 nervous system disease DOID:2377 G35 D009103 PS126200 miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis other hsa-mir-326 Multiple Sclerosis 29043654 nervous system disease DOID:2377 G35 D009103 PS126200 Evaluation of Selected MicroRNAs Expression in Remission Phase of Multiple Sclerosis and Their Potential Link to Cognition, Depression, and Disability. other hsa-mir-338 Multiple Sclerosis 21908875 nervous system disease DOID:2377 G35 D009103 PS126200 Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05). other hsa-mir-491 Multiple Sclerosis 21908875 nervous system disease DOID:2377 G35 D009103 PS126200 Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05). other hsa-mir-499a Multiple Sclerosis 26305248 nervous system disease DOID:2377 G35 D009103 PS126200 Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity. other hsa-mir-599 Multiple Sclerosis 19617918 nervous system disease DOID:2377 G35 D009103 PS126200 relevant at the time of relapse other hsa-mir-96 Multiple Sclerosis 19617918 nervous system disease DOID:2377 G35 D009103 PS126200 relevant at the time of relapse other hsa-mir-133a Muscle Diseases [unspecific] 25146754 M63.80 D009135 These miRNAs are potential biomarkers of muscle damage or adaptation to exercise. other hsa-mir-133a Muscle Diseases [unspecific] 23858090 M63.80 D009135 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. other hsa-mir-133a Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-133b Muscle Diseases [unspecific] 23858090 M63.80 D009135 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. other hsa-mir-133b Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-144 Muscle Diseases [unspecific] 24036467 M63.80 D009135 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. other hsa-mir-15a Muscle Diseases [unspecific] 24036467 M63.80 D009135 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. other hsa-mir-181b Muscle Diseases [unspecific] 24036467 M63.80 D009135 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. other hsa-mir-18a Muscle Diseases [unspecific] 24036467 M63.80 D009135 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. other hsa-mir-206 Muscle Diseases [unspecific] 25146754 M63.80 D009135 These miRNAs are potential biomarkers of muscle damage or adaptation to exercise. other hsa-mir-206 Muscle Diseases [unspecific] 23858090 M63.80 D009135 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. other hsa-mir-206 Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-206 Muscle Diseases [unspecific] 25678853 M63.80 D009135 MiR-206, a key modulator of skeletal muscle development and disease. other hsa-mir-20a Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-26 Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-30 Muscle Diseases [unspecific] 25689854 M63.80 D009135 These findings indicate that the miR-30 family may be an interesting biomarker of perturbed muscle homeostasis and muscle disease. other hsa-mir-30 Muscle Diseases [unspecific] 25547110 M63.80 D009135 human skeletal muscle differentiation and development in healthy and disease states. other hsa-mir-431 Muscle Diseases [unspecific] 26215566 M63.80 D009135 our results suggest that the age-associated miR-431 plays a key role in maintaining the myogenic ability of skeletal muscle with age. other hsa-mir-451 Muscle Diseases [unspecific] 24036467 M63.80 D009135 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. other hsa-mir-494 Muscle Diseases [unspecific] 27181718 M63.80 D009135 Effects of microRNA-494 on the fiber type-specific skeletal myogenesis in human induced pluripotent stem cells. other hsa-mir-499 Muscle Diseases [unspecific] 23858090 M63.80 D009135 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. other hsa-mir-608 Muscle Diseases [unspecific] 28358823 M63.80 D009135 Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy. other hsa-let-7 Muscular Dystrophy 26272747 G71.0 D009136 310200 HP:0003560 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. other hsa-let-7e Muscular Dystrophy 26272747 G71.0 D009136 310200 HP:0003560 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. other hsa-mir-125a Muscular Dystrophy 19690046 G71.0 D009136 310200 HP:0003560 regulation of ж┿myosin heavy chain gene other hsa-mir-146a Muscular Dystrophy 27671199 G71.0 D009136 310200 HP:0003560 Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. other hsa-mir-146a Muscular Dystrophy 28637335 G71.0 D009136 310200 HP:0003560 Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy. other hsa-mir-208b Muscular Dystrophy 19690046 G71.0 D009136 310200 HP:0003560 regulation of ж┿myosin heavy chain gene other hsa-mir-21 Muscular Dystrophy 25892183 G71.0 D009136 310200 HP:0003560 Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy. other hsa-mir-29 Muscular Dystrophy 25892183 G71.0 D009136 310200 HP:0003560 Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy. other hsa-mir-486 Muscular Dystrophy 24789910 G71.0 D009136 310200 HP:0003560 MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. other hsa-mir-98 Muscular Dystrophy 26272747 G71.0 D009136 310200 HP:0003560 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. other hsa-mir-206 Muscular Dystrophy, Duchenne 25999854 musculoskeletal system disease DOID:11723 G71.0 D020388 310200 In contrast, local expression of mIGF-1 promotes the modulation of other microRNAs, such as miR-206 and miR-24, along with the modulation of muscle specific genes other hsa-mir-21 Muscular Dystrophy, Duchenne 22213800 musculoskeletal system disease DOID:11723 G71.0 D020388 310200 PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. other hsa-mir-1 Muscular Dystrophy, Facioscapulohumeral 29741619 musculoskeletal system disease DOID:11727 G71.0 D020391 158900 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. other hsa-mir-133a Muscular Dystrophy, Facioscapulohumeral 29741619 musculoskeletal system disease DOID:11727 G71.0 D020391 158900 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. other hsa-mir-206 Muscular Dystrophy, Facioscapulohumeral 29741619 musculoskeletal system disease DOID:11727 G71.0 D020391 158900 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. other hsa-mir-146a Myasthenia Gravis 24036458 musculoskeletal system disease DOID:437 G70.0 D009157 254200 We conclude that abnormal expression/regulation of miR-146a may play an important role in the regulation of AchR specific B cells and contribute to the pathogenesis of MG. other hsa-mir-150 Myasthenia Gravis 26095457 musculoskeletal system disease DOID:437 G70.0 D009157 254200 The immuno-microRNAs miR-150-5p and miR-21-5p show a disease specific signature, which suggests these microRNAs as possible biological autoimmune markers of myasthenia gravis (MG). other hsa-mir-20b Myasthenia Gravis 27833920 musculoskeletal system disease DOID:437 G70.0 D009157 254200 miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis. other hsa-mir-21 Myasthenia Gravis 26095457 musculoskeletal system disease DOID:437 G70.0 D009157 254200 The immuno-microRNAs miR-150-5p and miR-21-5p show a disease specific signature, which suggests these microRNAs as possible biological autoimmune markers of myasthenia gravis (MG). other hsa-mir-132 Mycobacterium tuberculosis Infection 25252958 A18 D014376 607948 Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. other hsa-mir-26a Mycobacterium tuberculosis Infection 25252958 A18 D014376 607948 Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a. other hsa-mir-124 Myelodysplastic Syndromes 28024498 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Reactivated Expression of MicroRNA-124 in Patients with Myelodysplastic Syndromes after Demethylating Therapy. other hsa-mir-125a Myelodysplastic Syndromes 19615744 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome other hsa-mir-125a Myelodysplastic Syndromes 25976472 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 In fact, regulatory factors have also been considered as miR-143/miR-145, miR-146a, miR-125a and MiR-21. other hsa-mir-125b-1 Myelodysplastic Syndromes 22944560 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Myelodysplastic syndrome with a t(2;11)(p21;q23-24) and translocation breakpoint close to miR-125b-1. other hsa-mir-143 Myelodysplastic Syndromes 22929976 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Lenalidomide selectively abrogated progenitor activity in cells depleted of miR-143 and miR-145 supporting a key role for miR-143/145 in the sensitivity to lenalidomide of del(5q) myelodysplastic syndrome patients. other hsa-mir-145 Myelodysplastic Syndromes 19898489 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 5q- syndrome deleted,Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype other hsa-mir-145 Myelodysplastic Syndromes 22929976 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Lenalidomide selectively abrogated progenitor activity in cells depleted of miR-143 and miR-145 supporting a key role for miR-143/145 in the sensitivity to lenalidomide of del(5q) myelodysplastic syndrome patients. other hsa-mir-145 Myelodysplastic Syndromes 20733155 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. Lenalidomide has become an established therapy for the 5q- syndrome, although its precise mode of action remains uncertain. other hsa-mir-145 Myelodysplastic Syndromes 24507813 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Other genes, as well as miR-145 and miR-146a, contribute to aberrant megakaryopoiesis and a selective advantage for the del(5q) clone. other hsa-mir-146a Myelodysplastic Syndromes 19898489 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 5q- syndrome deleted,Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype other hsa-mir-146a Myelodysplastic Syndromes 20733155 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. Lenalidomide has become an established therapy for the 5q- syndrome, although its precise mode of action remains uncertain. other hsa-mir-146a Myelodysplastic Syndromes 25071842 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 miR-146a is also implicated in the pathogenesis of human myelodysplastic syndromes (MDSs) as it is located within a commonly deleted region on chromosome 5, and miR-146a-deficient mice exhibit features of an MDS-like disease. other hsa-mir-155 Myelodysplastic Syndromes 22249254 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. other hsa-mir-155 Myelodysplastic Syndromes 27513856 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 In the current study, we identified overexpression of c-Fos-targeting miR-34a and miR-155 as the cause of impairment. other hsa-mir-155 Myelodysplastic Syndromes 28130497 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. other hsa-mir-15a Myelodysplastic Syndromes 19702585 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 differentially expressed between low-risk and high-risk other hsa-mir-210 Myelodysplastic Syndromes 22249254 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. other hsa-mir-221 Myelodysplastic Syndromes 19615744 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome other hsa-mir-222 Myelodysplastic Syndromes 19615744 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome other hsa-mir-34a Myelodysplastic Syndromes 27513856 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 In the current study, we identified overexpression of c-Fos-targeting miR-34a and miR-155 as the cause of impairment. other hsa-mir-34a Myelodysplastic Syndromes 28130497 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. other hsa-mir-378 Myelodysplastic Syndromes 27633496 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. other hsa-mir-378a Myelodysplastic Syndromes 21703983 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls. other hsa-mir-632 Myelodysplastic Syndromes 21703983 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls. other hsa-mir-636 Myelodysplastic Syndromes 21703983 disease of cellular proliferation DOID:0050908 D46.9 D009190 614286 HP:0002863 hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls. other hsa-mir-34a Myelofibrosis 28098757 disease of cellular proliferation DOID:4971 D47.4 D055728 254450 HP:0011974 the increased expression of miR-34a-5p in PMF HPCs could be important for the skewing of megakaryopoiesis and the production of monocytes, that are key players in BM fibrosis in PMF patients other hsa-mir-130a Myeloma 26389804 C90.0 D009101 254500 Together, our data suggest connection between lower level of microRNA-130a and extramedullary disease and prompt further work to evaluate this miRNA as a marker of extramedullary disease in multiple myeloma. other hsa-mir-19a Myeloma 27830963 C90.0 D009101 254500 MicroRNA-19a functions as an oncogene by regulating PTEN/AKT/pAKT pathway in myeloma. other hsa-mir-143 Myeloproliferative Neoplasms 25527813 disease of cellular proliferation DOID:2226 D47.1 616871 Our findings of aberrant miR-143 expression support the concept that factors other than JAK2 V617F mutation may contribute to the pathogenesis and some clinical signs of MPNs. other hsa-mir-15a Myeloproliferative Neoplasms 20008792 disease of cellular proliferation DOID:2226 D47.1 616871 STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. other hsa-mir-15b Myeloproliferative Neoplasms 20008792 disease of cellular proliferation DOID:2226 D47.1 616871 STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. other hsa-mir-16 Myeloproliferative Neoplasms 20008792 disease of cellular proliferation DOID:2226 D47.1 616871 STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. other hsa-mir-433 Myeloproliferative Neoplasms 22864358 disease of cellular proliferation DOID:2226 D47.1 616871 miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. other hsa-let-7b Myocardial Infarction 28062497 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. other hsa-mir-1 Myocardial Infarction 20163779 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 We conclude that miR-1 and miR-133 seem to be important regulators of heart adaptation after ischaemic stress. other hsa-mir-1 Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-1 Myocardial Infarction 23625462 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells. other hsa-mir-1 Myocardial Infarction 25588055 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Downregulation of IGF1 specific miRNA-1 and -133 but not miR-145 expression was also confirmed. other hsa-mir-1 Myocardial Infarction 26065643 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 spironolactone could increase miRNA-1 expression in ischemic rat myocardium after MI other hsa-mir-1 Myocardial Infarction 27056419 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential other hsa-mir-1 Myocardial Infarction 28894747 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 regulatory effects on miR-1, miR-133, Cx43, and Cx45 might be a possible mechanism of WXKL in the treatment of MI at the gene level other hsa-mir-1 Myocardial Infarction 29094045 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. other hsa-mir-1 Myocardial Infarction 29212255 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Soluble epoxide hydrolase inhibitors, t-AUCB, regulated microRNA-1 and its target genes in myocardial infarction mice other hsa-mir-1 Myocardial Infarction 29324314 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 up-regulation of miR-1 and miR-208 in remote myocardium might play a role in cardiac remodeling after MI, at least to certain degree other hsa-mir-103 Myocardial Infarction 25867756 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. other hsa-mir-106b Myocardial Infarction 22613985 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MiR-106b and MiR-15b modulate apoptosis and angiogenesis in myocardial infarction. other hsa-mir-126 Myocardial Infarction 21949332 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003). other hsa-mir-126 Myocardial Infarction 18694565 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 We show that an endothelial cell-restricted microRNA (miR-126) mediates developmental angiogenesis in vivo. other hsa-mir-126 Myocardial Infarction 22113756 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Transplantation of MSCs transfected with miR-126 can improve angiogenesis and cardiac function in the infarcted area of the hearts of mice, which may be due to stimulation of the AKT/ERK-related pathway. other hsa-mir-126 Myocardial Infarction 25200057 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Exosomes purified from endothelial cells overexpressing HIF1 had higher contents of miR-126 and miR-210. other hsa-mir-126 Myocardial Infarction 27180261 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation. other hsa-mir-130a Myocardial Infarction 27789328 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Resveratrol increases microRNA-130a expression to promote angiogenesis and improve heart functions in mice after myocardial infarction. other hsa-mir-133 Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-133 Myocardial Infarction 28894747 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 regulatory effects on miR-1, miR-133, Cx43, and Cx45 might be a possible mechanism of WXKL in the treatment of MI at the gene level other hsa-mir-133b Myocardial Infarction 20163779 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 We conclude that miR-1 and miR-133 seem to be important regulators of heart adaptation after ischaemic stress. other hsa-mir-145 Myocardial Infarction 28980287 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Inducible miR-145 expression by HIF-1a protects cardiomyocytes against apoptosis via regulating SGK1 in simulated myocardial infarction hypoxic microenvironment. other hsa-mir-150 Myocardial Infarction 23547171 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-150: A Novel Marker of Left Ventricular Remodeling After Acute Myocardial Infarction other hsa-mir-151 Myocardial Infarction 24039836 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation. other hsa-mir-155 Myocardial Infarction 28129114 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury. other hsa-mir-16 Myocardial Infarction 25867756 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. other hsa-mir-197 Myocardial Infarction 21949332 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003). other hsa-mir-199a Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-206 Myocardial Infarction 27103465 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 In an acute model of myocardial infarction, transplanted hypoxic MSCs showed a significantly improved survival as compared with hypoxic MSCs overexpressing miR-206. other hsa-mir-206 Myocardial Infarction 29055786 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury. other hsa-mir-208 Myocardial Infarction 29324314 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 up-regulation of miR-1 and miR-208 in remote myocardium might play a role in cardiac remodeling after MI, at least to certain degree other hsa-mir-208a Myocardial Infarction 25828373 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Targeting MicroRNA-208a to Suppress Adverse Postmyocardial Infarction Remodelling Related to RNA Activation of Endoglin Gene Expression. other hsa-mir-208a Myocardial Infarction 29506703 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction other hsa-mir-208b Myocardial Infarction 23448306 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. other hsa-mir-21 Myocardial Infarction 19147588 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-21: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue other hsa-mir-21 Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-21 Myocardial Infarction 22760500 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium. other hsa-mir-21 Myocardial Infarction 26168042 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 losartan treatment significantly increased microRNA (miR)-1, -15b, -92a, -133a, -133b, -210, and -499 expression but decreased miR-21 in the left ventricle. other hsa-mir-21 Myocardial Infarction 27708252 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway. other hsa-mir-21 Myocardial Infarction 28170197 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. other hsa-mir-21 Myocardial Infarction 28699517 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Circadian MicroRNAs in Cardioprotection. other hsa-mir-21 Myocardial Infarction 29506703 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction other hsa-mir-210 Myocardial Infarction 20837903 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-210:MicroRNA-210 can improve angiogenesis, inhibit apoptosis, and improve cardiac function in a murine model of myocardial infarction. other hsa-mir-210 Myocardial Infarction 23388440 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 These data demonstrated that a positive feedback loop involving miR-210 and HIF-1α was important for MSC survival under hypoxic conditions. other hsa-mir-210 Myocardial Infarction 25016614 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNAs most highly enriched in EVs secreted by CPCs compared with fibroblasts included miR-210, miR-132, and miR-146a-3p. other hsa-mir-210 Myocardial Infarction 28948298 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. other hsa-mir-210 Myocardial Infarction 29484401 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-210 promotes angiogenesis in acute myocardial infarction other hsa-mir-22 Myocardial Infarction 29063105 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-22 plays critical roles in MI and subsequent cardiac remodeling other hsa-mir-223 Myocardial Infarction 21949332 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003). other hsa-mir-23 Myocardial Infarction 24864093 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA--a new diagnostic tool in coronary artery disease and myocardial infarction. other hsa-mir-23a Myocardial Infarction 24269648 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-23a is involved in tumor necrosis factor-α induced apoptosis in mesenchymal stem cells and myocardial infarction. other hsa-mir-24-1 Myocardial Infarction 21788589 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-24 Regulates Vascularity After Myocardial Infarction other hsa-mir-24-1 Myocardial Infarction 22260784 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-24 Regulates Cardiac Fibrosis after Myocardial Infarction. other hsa-mir-24-2 Myocardial Infarction 21788589 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-24 Regulates Vascularity After Myocardial Infarction other hsa-mir-24-2 Myocardial Infarction 22260784 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-24 Regulates Cardiac Fibrosis after Myocardial Infarction. other hsa-mir-26 Myocardial Infarction 25867756 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. other hsa-mir-29 Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-29b Myocardial Infarction 28722488 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b. other hsa-mir-31 Myocardial Infarction 28865712 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. other hsa-mir-320 Myocardial Infarction 25867756 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. other hsa-mir-320 Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-322 Myocardial Infarction 20972335 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis. other hsa-mir-34a Myocardial Infarction 29559958 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-34a, a microRNA known to promote pro-apoptotic role in myocardial infarction during degenerative process of cardiac injuries thus indicating intrinsic differences in the nature of the mechanisms underlying the heart failure triggered by Trypanosoma cruzi infection. other hsa-mir-377 Myocardial Infarction 26564601 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 The present study is timely because the field is eagerly awaiting the results of the large phase III BAMI (Bone Marrow-Derived Mononuclear Cells on All-Cause Mortality in Myocardial Infarction; NCT01569178) clinical trial. If this clinical trial turns out positively, approaches such as the one developed by Joladarashi et al. will have additional relevance to the field. other hsa-mir-378 Myocardial Infarction 28062497 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. other hsa-mir-424 Myocardial Infarction 20972335 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis. other hsa-mir-499 Myocardial Infarction 25111390 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Our results demonstrate that circulating miR-499 is a novel, early biomarker for identifying perioperative myocardial infarction in cardiac surgery. other hsa-mir-499 Myocardial Infarction 21186368 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Here we report that modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of myocardial infarction and cardiac dysfunction induced by ischemia-reperfusion. other hsa-mir-499 Myocardial Infarction 23448306 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. other hsa-mir-499 Myocardial Infarction 24363996 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Treatment with cLA and nitrite significantly induced levels of miRNA-499 compared to untreated MI mice. other hsa-mir-499 Myocardial Infarction 27056419 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 miR-208/499 located in introns of the heavy chain myosin genes regulate expression of sarcomeric contractile proteins. other hsa-mir-499 Myocardial Infarction 29506703 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction other hsa-mir-92a Myocardial Infarction 20959496 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. other hsa-mir-103 Myocardial Infarction 26038570 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Our results reveal a novel myocardial necrosis regulation model,which is composed of H19, miR-103/107, and FADD. Modulation of their levels may provide a new approach for preventing myocardial necrosis. other hsa-mir-107 Myocardial Infarction 26038570 cardiovascular system disease DOID:5844 I21 D009203 608557 HP:0001658 Our results reveal a novel myocardial necrosis regulation model,which is composed of H19, miR-103/107, and FADD. Modulation of their levels may provide a new approach for preventing myocardial necrosis. other hsa-mir-1 Myocardial Ischemic-Reperfusion Injury 29505745 D015428 Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway other hsa-mir-146a Myocardial Ischemic-Reperfusion Injury 23208587 D015428 Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury other hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 24825878 D015428 Na2S induces cardioprotective effects through miR-21-dependent attenuation of ischemic and inflammatory injury in cardiomyocytes. other hsa-mir-29a Myocardial Ischemic-Reperfusion Injury 26844226 D015428 After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1. other hsa-mir-376b Myocardial Ischemic-Reperfusion Injury 22396777 D015428 M(3) Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p. other hsa-mir-125b Narcolepsy 26028057 disease of mental health DOID:8986 G47.41 D009290 PS161400 HP:0030050 we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy. other hsa-mir-130a Narcolepsy 26028057 disease of mental health DOID:8986 G47.41 D009290 PS161400 HP:0030050 we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy. other hsa-mir-155 Narcolepsy 26028057 disease of mental health DOID:8986 G47.41 D009290 PS161400 HP:0030050 we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy. other hsa-mir-26a Narcolepsy 26028057 disease of mental health DOID:8986 G47.41 D009290 PS161400 HP:0030050 we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy. other hsa-mir-30c Narcolepsy 26028057 disease of mental health DOID:8986 G47.41 D009290 PS161400 HP:0030050 we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy. other hsa-mir-296 Nasal Cavity Inverting Papilloma 28693263 disease of cellular proliferation DOID:4633 Role of microRNA-296-3p in the malignant transformation of sinonasal inverted papilloma. other hsa-mir-149 Nasopharyngeal Neoplasms 21873783 C11.9 D009303 607107 HP:0100630 miR-149 promotes epithelial-mesenchymal transition and invasion in nasopharyngeal carcinoma cells. other hsa-mir-155 Nasopharyngeal Neoplasms 21541331 C11.9 D009303 607107 HP:0100630 Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A. other hsa-mir-18a Nasopharyngeal Neoplasms 23097559 C11.9 D009303 607107 HP:0100630 miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma other hsa-mir-18b Nasopharyngeal Neoplasms 23764853 C11.9 D009303 607107 HP:0100630 Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. other hsa-mir-29c Nasopharyngeal Neoplasms 23142283 C11.9 D009303 607107 HP:0100630 MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy other hsa-let-7 Neoplasms [unspecific] 24703842 C80.1 D009369 We conclude that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression. other hsa-let-7 Neoplasms [unspecific] 26080928 C80.1 D009369 these results suggest that cytoplasmic uridylation pathway actively participates in blockade of let-7 biogenesis by Lin28B. other hsa-let-7 Neoplasms [unspecific] 26187994 C80.1 D009369 Our data reveal an unexpected role of Rho-associated, coiled-coil-containing protein kinase (ROCK1) as a cofactor of HNF4A in enhancing PAIP2 transcription. Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors may be useful for the various pathologies associated with the impairment of global miRNA function. other hsa-let-7 Neoplasms [unspecific] 27097729 C80.1 D009369 The insights of Let-7 miRNAs in oncogenesis and stem cell potency. other hsa-let-7 Neoplasms [unspecific] 27659051 C80.1 D009369 Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies other hsa-let-7 Neoplasms [unspecific] 28004230 C80.1 D009369 In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences. other hsa-let-7 Neoplasms [unspecific] 28070818 C80.1 D009369 Entangling Relation of Micro RNA-let7, miRNA-200 and miRNA-125 with Various Cancers. other hsa-let-7 Neoplasms [unspecific] 28446596 C80.1 D009369 Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. other hsa-let-7 Neoplasms [unspecific] 29644076 C80.1 D009369 These observations emphasize the central importance of IGF signaling pathways in the mediation of intragenomic conflicts over embryonic growth and identify possible targets for therapeutic interventions in cancer other hsa-let-7a Neoplasms [unspecific] 26420675 C80.1 D009369 Target-Catalyzed DNA Four-Way Junctions for CRET Imaging of MicroRNA,Concatenated Logic Operations, and Self-Assembly of DNA Nanohydrogels for Targeted Drug Delivery. other hsa-let-7a Neoplasms [unspecific] 25759134 C80.1 D009369 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-let-7a Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7a Neoplasms [unspecific] 17554199 C80.1 D009369 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). other hsa-let-7a Neoplasms [unspecific] 27659051 C80.1 D009369 Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies other hsa-let-7a-1 Neoplasms [unspecific] 18560417 C80.1 D009369 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7a-1 Neoplasms [unspecific] 19221491 C80.1 D009369 let-7a: guardians against pluripotency and cancer progression other hsa-let-7a-2 Neoplasms [unspecific] 18560417 C80.1 D009369 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7a-2 Neoplasms [unspecific] 19221491 C80.1 D009369 let-7a: guardians against pluripotency and cancer progression other hsa-let-7a-3 Neoplasms [unspecific] 18560417 C80.1 D009369 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7a-3 Neoplasms [unspecific] 19221491 C80.1 D009369 let-7a: guardians against pluripotency and cancer progression other hsa-let-7b Neoplasms [unspecific] 18560417 C80.1 D009369 let-7b: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7b Neoplasms [unspecific] 19221491 C80.1 D009369 let-7b: guardians against pluripotency and cancer progression other hsa-let-7b Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7b Neoplasms [unspecific] 25946136 C80.1 D009369 Let-7 may represent a new class of chemosensitizer for the treatment of KRAS mutant tumors. other hsa-let-7c Neoplasms [unspecific] 18560417 C80.1 D009369 let-7c: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7c Neoplasms [unspecific] 19221491 C80.1 D009369 let-7c: guardians against pluripotency and cancer progression other hsa-let-7c Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7c Neoplasms [unspecific] 27087117 C80.1 D009369 microRNA let-7c (let-7c) contributed to the anisomycin-induced apoptosis other hsa-let-7d Neoplasms [unspecific] 18560417 C80.1 D009369 let-7d: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7d Neoplasms [unspecific] 19221491 C80.1 D009369 let-7d: guardians against pluripotency and cancer progression other hsa-let-7d Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7e Neoplasms [unspecific] 18560417 C80.1 D009369 let-7e: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7e Neoplasms [unspecific] 19221491 C80.1 D009369 let-7e: guardians against pluripotency and cancer progression other hsa-let-7e Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7f Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7f-1 Neoplasms [unspecific] 18560417 C80.1 D009369 let-7f: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7f-1 Neoplasms [unspecific] 19221491 C80.1 D009369 let-7f: guardians against pluripotency and cancer progression other hsa-let-7f-2 Neoplasms [unspecific] 18560417 C80.1 D009369 let-7f: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7f-2 Neoplasms [unspecific] 19221491 C80.1 D009369 let-7f: guardians against pluripotency and cancer progression other hsa-let-7g Neoplasms [unspecific] 18560417 C80.1 D009369 let-7g: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7g Neoplasms [unspecific] 19221491 C80.1 D009369 let-7g: guardians against pluripotency and cancer progression other hsa-let-7g Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-let-7g Neoplasms [unspecific] 27659051 C80.1 D009369 Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies other hsa-let-7i Neoplasms [unspecific] 18560417 C80.1 D009369 let-7i: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication other hsa-let-7i Neoplasms [unspecific] 19221491 C80.1 D009369 let-7i: guardians against pluripotency and cancer progression other hsa-let-7i Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-mir-1 Neoplasms [unspecific] 25899823 C80.1 D009369 Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications. other hsa-mir-1 Neoplasms [unspecific] 29642568 C80.1 D009369 A single sub-lethal dose of irradiation has been shown to result in compensatory up-regulation of the myocardial connexin-43 (Cx43), activation of the protein kinase C (PKC) signaling along with the decline of microRNA (miR)-1 and an increase of miR-21 levels in the left ventricle (LV) other hsa-mir-1 Neoplasms [unspecific] 27286699 C80.1 D009369 miR-1 is classified to be a tumor suppressor other hsa-mir-100 Neoplasms [unspecific] 24258109 C80.1 D009369 Prognostic role of microRNA-100 in various carcinomas: evidence from six studies. other hsa-mir-100 Neoplasms [unspecific] 24903380 C80.1 D009369 the prognostic role of miR-100 in human cancers, and thus, much more works are needed in this field. other hsa-mir-101 Neoplasms [unspecific] 26145175 C80.1 D009369 MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. other hsa-mir-101 Neoplasms [unspecific] 20617180 C80.1 D009369 Up-regulating miR-101 efficiently reduced the protein levels of DNA-PKcs and ATM in these tumor cells and most importantly, sensitized the tumor cells to radiation in vitro and in vivo. other hsa-mir-101 Neoplasms [unspecific] 26005707 C80.1 D009369 eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function. other hsa-mir-105 Neoplasms [unspecific] 23950948 C80.1 D009369 miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. other hsa-mir-106a Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-106a Neoplasms [unspecific] 27780637 C80.1 D009369 MiR-106a: Promising biomarker for cancer. other hsa-mir-106b Neoplasms [unspecific] 25286029 C80.1 D009369 miR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells. other hsa-mir-106b Neoplasms [unspecific] 18922889 C80.1 D009369 miR-106b: key modulators of TGFbeta signaling other hsa-mir-106b Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-107 Neoplasms [unspecific] 20833636 C80.1 D009369 p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. other hsa-mir-10b Neoplasms [unspecific] 24503738 C80.1 D009369 Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. other hsa-mir-10b Neoplasms [unspecific] 25426550 C80.1 D009369 miR-520d-5p leads to reduced proliferation of tumor cells, and that high levels of miR-520d-5p correlate with higher survival rates of cancer patients. other hsa-mir-10b Neoplasms [unspecific] 20444703 C80.1 D009369 miR-10b:miR-10b targets Tiam1: implications for Rac activation and carcinoma migration other hsa-mir-10b Neoplasms [unspecific] 18256538 C80.1 D009369 pro-metastatic other hsa-mir-10b Neoplasms [unspecific] 20351690 C80.1 D009369 Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model other hsa-mir-10b Neoplasms [unspecific] 28989695 C80.1 D009369 Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy. other hsa-mir-122 Neoplasms [unspecific] 26360933 C80.1 D009369 In conclusion, administration of TSA in hepatogenic differentiation of hAT-MSCs resulted in higher expression levels of miR-122,facilitation of differentiation, and subsequently attenuation of AFP levels. other hsa-mir-122 Neoplasms [unspecific] 26187994 C80.1 D009369 Our data reveal an unexpected role of Rho-associated, coiled-coil-containing protein kinase (ROCK1) as a cofactor of HNF4A in enhancing PAIP2 transcription. Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors may be useful for the various pathologies associated with the impairment of global miRNA function. other hsa-mir-1224 Neoplasms [unspecific] 21320120 C80.1 D009369 Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-alpha gene expression by modulating Sp1. other hsa-mir-1228 Neoplasms [unspecific] 24488924 C80.1 D009369 Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients. other hsa-mir-125a Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-125a Neoplasms [unspecific] 28197019 C80.1 D009369 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. other hsa-mir-125b Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-125b Neoplasms [unspecific] 23800395 C80.1 D009369 The expression and regulation of microRNA-125b in cancers. other hsa-mir-125b Neoplasms [unspecific] 26138442 C80.1 D009369 MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia. other hsa-mir-125b Neoplasms [unspecific] 25403182 C80.1 D009369 these findings illuminate miR-125b as an important microRNA regulator that is shared between normal skin progenitors and their early malignant counterparts. other hsa-mir-125b Neoplasms [unspecific] 27500388 C80.1 D009369 along with modulation of wt-p53 and miR-125b expression, we also show that the exosomes (i.e., wt-p53/exo, miR-125b/exo and combination/exo) have a reprogramed global miRNA profile. other hsa-mir-125b Neoplasms [unspecific] 27321180 C80.1 D009369 Forced expression of hsa-miR-125b in these cells resulted in radiosensitivity other hsa-mir-125b-1 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-125b:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs other hsa-mir-125b-1 Neoplasms [unspecific] 22268450 C80.1 D009369 Camptothecin Induces Apoptosis in Cancer Cells via miR-125b Mediated Mitochondrial Pathways. other hsa-mir-125b-1 Neoplasms [unspecific] 23437196 C80.1 D009369 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1ж┿pathway. other hsa-mir-125b-1 Neoplasms [unspecific] 23497288 C80.1 D009369 miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor other hsa-mir-125b-2 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-125b:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs other hsa-mir-125b-2 Neoplasms [unspecific] 22268450 C80.1 D009369 Camptothecin Induces Apoptosis in Cancer Cells via miR-125b Mediated Mitochondrial Pathways. other hsa-mir-125b-2 Neoplasms [unspecific] 23437196 C80.1 D009369 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1ж┿pathway. other hsa-mir-125b-2 Neoplasms [unspecific] 23497288 C80.1 D009369 miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor other hsa-mir-126 Neoplasms [unspecific] 24368110 C80.1 D009369 miR-126 in human cancers: clinical roles and current perspectives. other hsa-mir-126 Neoplasms [unspecific] 25999416 C80.1 D009369 This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively. other hsa-mir-126 Neoplasms [unspecific] 27583885 C80.1 D009369 Potential role of microRNA-126 in the diagnosis of cancers: A systematic review and meta-analysis. other hsa-mir-130 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-132 Neoplasms [unspecific] 20676106 C80.1 D009369 miR-132:miR-132 was highly expressed in the endothelium of human tumors and hemangiomas other hsa-mir-132 Neoplasms [unspecific] 18075311 C80.1 D009369 In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs. other hsa-mir-133 Neoplasms [unspecific] 28004230 C80.1 D009369 In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences. other hsa-mir-137 Neoplasms [unspecific] 28004230 C80.1 D009369 In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences. other hsa-mir-138 Neoplasms [unspecific] 26138095 C80.1 D009369 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-138-1 Neoplasms [unspecific] 23300839 C80.1 D009369 MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity other hsa-mir-138-2 Neoplasms [unspecific] 23300839 C80.1 D009369 MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity other hsa-mir-139 Neoplasms [unspecific] 25691250 C80.1 D009369 MiR-139-5p: promising biomarker for cancer. other hsa-mir-139 Neoplasms [unspecific] 27022656 C80.1 D009369 The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. other hsa-mir-139 Neoplasms [unspecific] 28119089 C80.1 D009369 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. other hsa-mir-141 Neoplasms [unspecific] 25403569 C80.1 D009369 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. other hsa-mir-141 Neoplasms [unspecific] 25889350 C80.1 D009369 The DNA tweezers also show high selectivity toward the fuel strand and can be used to monitor miR-141 expression in cancer cells, which provides new opportunities for the application of the dynamic DNA devices in clinical diagnostics. other hsa-mir-141 Neoplasms [unspecific] 26439017 C80.1 D009369 Coupling hybridization chain reaction with catalytic hairpin assembly enables non-enzymatic and sensitive fluorescent detection of microRNA cancer biomarkers. other hsa-mir-141 Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-141 Neoplasms [unspecific] 18829540 C80.1 D009369 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. other hsa-mir-141 Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-142 Neoplasms [unspecific] 24227773 C80.1 D009369 Two specific miRNAs transferred efficiently between these cells--miR-142 and miR-223--and both were endogenously expressed in macrophages and not in HCCs. other hsa-mir-143 Neoplasms [unspecific] 25486198 C80.1 D009369 identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients. other hsa-mir-143 Neoplasms [unspecific] 25999416 C80.1 D009369 This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively. other hsa-mir-143 Neoplasms [unspecific] 25477374 C80.1 D009369 differences in these tumor suppressors might contribute to regional differences in normal colonic gene expression and modulate site-specific differences in malignant predisposition. other hsa-mir-143 Neoplasms [unspecific] 26988859 C80.1 D009369 The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles. other hsa-mir-143 Neoplasms [unspecific] 28038917 C80.1 D009369 A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. other hsa-mir-143 Neoplasms [unspecific] 28119089 C80.1 D009369 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. other hsa-mir-145 Neoplasms [unspecific] 25999416 C80.1 D009369 This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively. other hsa-mir-145 Neoplasms [unspecific] 25476854 C80.1 D009369 large-scale prospective studies and additional improvements are urgently needed to confirm our findings and its utilization for routine clinical diagnosis in future. other hsa-mir-145 Neoplasms [unspecific] 24657914 C80.1 D009369 miR-145 and its influence on tumor growth in systemic malignancies. other hsa-mir-145 Neoplasms [unspecific] 25477374 C80.1 D009369 differences in these tumor suppressors might contribute to regional differences in normal colonic gene expression and modulate site-specific differences in malignant predisposition. other hsa-mir-145 Neoplasms [unspecific] 26988859 C80.1 D009369 The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles. other hsa-mir-145 Neoplasms [unspecific] 26168819 C80.1 D009369 Treatments of T-CIN+ cells with senescence-conditioned media induce sphere formation exclusively in cells with senescence-associated tumorigenicity, a capacity that depends on miR-145 repression. other hsa-mir-145 Neoplasms [unspecific] 28119089 C80.1 D009369 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. other hsa-mir-146a Neoplasms [unspecific] 20144731 C80.1 D009369 miR-146:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs other hsa-mir-146a Neoplasms [unspecific] 23200854 C80.1 D009369 Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity other hsa-mir-146a Neoplasms [unspecific] 23796062 C80.1 D009369 Our results indicated that ectopic expression of miR-146a could not independently induce differentiation in lymphoblastic cells. However, the expression of multiple genes involved in T-cell differentiation and T-cell CD markers were found to be affected. These results have suggested a potential tumor suppressive, immunomodulatory and cell activator role for miR146-a. other hsa-mir-146a Neoplasms [unspecific] 26549232 C80.1 D009369 Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions. other hsa-mir-146a Neoplasms [unspecific] 21555486 C80.1 D009369 miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. other hsa-mir-146a Neoplasms [unspecific] 22453030 C80.1 D009369 In this review we focus on recent progress in analyzing the functional role of miR-146a in the control of normal and malignant hematopoiesis. other hsa-mir-146a Neoplasms [unspecific] 19021527 C80.1 D009369 In the present article, we review the evidence for a role of miR-146a in innate immunity and cancer and assess whether changes in miR-146a might link these two biological responses. other hsa-mir-146a Neoplasms [unspecific] 28197019 C80.1 D009369 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. other hsa-mir-146b Neoplasms [unspecific] 20406109 C80.1 D009369 miR-146b:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs other hsa-mir-147 Neoplasms [unspecific] 24454732 C80.1 D009369 MicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistance. other hsa-mir-148a Neoplasms [unspecific] 26124099 C80.1 D009369 MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC. other hsa-mir-149 Neoplasms [unspecific] 25916550 C80.1 D009369 Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. other hsa-mir-150 Neoplasms [unspecific] 26170969 C80.1 D009369 iR-150 may be a potential biomarker and therapeutic target in the diagnosis and treatment of various malignancies. other hsa-mir-152 Neoplasms [unspecific] 25578780 C80.1 D009369 XIST in GSCs and important clues for understanding the key roles of lncRNA-miRNA functionalnetwork in human glioma. other hsa-mir-155 Neoplasms [unspecific] 24122356 C80.1 D009369 microRNA-155 has functions in the control of various cancers other hsa-mir-155 Neoplasms [unspecific] 24716910 C80.1 D009369 MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis. other hsa-mir-155 Neoplasms [unspecific] 25486872 C80.1 D009369 miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton's tyrosine kinase inhibition with Ibrutinib. other hsa-mir-155 Neoplasms [unspecific] 25548153 C80.1 D009369 overexpression of miR-155 in tumor-specific T cells can be used to increase the effectiveness of adoptive immunotherapies in a cell-intrinsic manner without the need for life-threatening, lymphodepleting maneuvers. other hsa-mir-155 Neoplasms [unspecific] 26317550 C80.1 D009369 Our results demonstrate that miR-155 inhibits the ability of cancer cells to extravasate and/or colonize at distant organs and brings additional insight into the complexity of miR-155 regulation in metastatic seeding. other hsa-mir-155 Neoplasms [unspecific] 25918453 C80.1 D009369 Our data suggest that single miR-155 profiling has a potential to be used as a screening test for various carcinomas, and parallel testing of miR-155 confers an improved specificity compared to single miR-155 analysis. other hsa-mir-155 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-155:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs other hsa-mir-155 Neoplasms [unspecific] 23200854 C80.1 D009369 Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity other hsa-mir-155 Neoplasms [unspecific] 24687397 C80.1 D009369 In HepG2 cells, exogenous NO increases miR-155 expression, but endogenous basal NO inhibits it. Both effects are mediated via cGMP/PKG signaling. The upregulation of miR-155 by NO provides a new link between NO, inflammation, and cancer. other hsa-mir-155 Neoplasms [unspecific] 26771315 C80.1 D009369 Screening of Pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays. other hsa-mir-155 Neoplasms [unspecific] 27602769 C80.1 D009369 MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/β-catenin signaling pathways. other hsa-mir-155 Neoplasms [unspecific] 28162271 C80.1 D009369 Nitric Oxide: Genomic Instability And Synthetic Lethality. other hsa-mir-155 Neoplasms [unspecific] 28197019 C80.1 D009369 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. other hsa-mir-155 Neoplasms [unspecific] 28256712 C80.1 D009369 Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study. other hsa-mir-155 Neoplasms [unspecific] 28912267 C80.1 D009369 Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade. other hsa-mir-155 Neoplasms [unspecific] 29366836 C80.1 D009369 Increased miR-155 expression was associated with poorer survival in human carcinoma and as such may be valuable in predicting outcome other hsa-mir-15a Neoplasms [unspecific] 25945419 C80.1 D009369 these data demonstrate that miR-15a/16 induced autophagy contribute partly to their inhibition of cell proliferation and enhanced chemotherapeutic efficacy of camptothecin(CPT). other hsa-mir-15a Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-15a Neoplasms [unspecific] 23353574 C80.1 D009369 Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines other hsa-mir-15a Neoplasms [unspecific] 25540364 C80.1 D009369 viral RNAs can exert their functions as competing endogenous RNAs (ceRNAs) toward microRNA and participate in important cellular processes. other hsa-mir-15a Neoplasms [unspecific] 26260813 C80.1 D009369 miRNA-15a/16: as tumor suppressors and more. other hsa-mir-16 Neoplasms [unspecific] 26031775 C80.1 D009369 Our findings provide the first clues regarding the role of miR-16 as a tumor suppressor in cancer cells through the inhibition of FEAT translation. other hsa-mir-16 Neoplasms [unspecific] 25486198 C80.1 D009369 identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients. other hsa-mir-16 Neoplasms [unspecific] 25945419 C80.1 D009369 these data demonstrate that miR-15a/16 induced autophagy contribute partly to their inhibition of cell proliferation and enhanced chemotherapeutic efficacy of camptothecin(CPT). other hsa-mir-16 Neoplasms [unspecific] 26260813 C80.1 D009369 miRNA-15a/16: as tumor suppressors and more. other hsa-mir-16 Neoplasms [unspecific] 25787082 C80.1 D009369 In addition, we observed significantly reduced expression of microRNAs (miRNAs) including miR-16 and miR-19b, which are known to be significantly reduced in the semen of infertile men. other hsa-mir-16 Neoplasms [unspecific] 28670496 C80.1 D009369 Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators. other hsa-mir-16-1 Neoplasms [unspecific] 19269153 C80.1 D009369 miR-16: can be upregulated by Epigallocatechin gallate other hsa-mir-16-1 Neoplasms [unspecific] 20668064 C80.1 D009369 miR-16:miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis other hsa-mir-16-1 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-16-2 Neoplasms [unspecific] 19269153 C80.1 D009369 miR-16: can be upregulated by Epigallocatechin gallate other hsa-mir-16-2 Neoplasms [unspecific] 20668064 C80.1 D009369 miR-16:miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis other hsa-mir-17 Neoplasms [unspecific] 24598644 C80.1 D009369 Effect of microRNA-17-92 cluster on the biological characteristics of K562 cells and its mechanisms. other hsa-mir-17 Neoplasms [unspecific] 26255770 C80.1 D009369 developmentally regulated pro-miRNA processing is a key step controlling miRNA expression and explains the posttranscriptional control of miR-17-92 expression in development. other hsa-mir-17 Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-17 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-17 Neoplasms [unspecific] 18700987 C80.1 D009369 miR-17-5p: The miR-17-5p microRNA is able to act as both an oncogene and a tumor suppressor in different cellular contexts other hsa-mir-17 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-17: key modulators of TGFbeta signaling other hsa-mir-17 Neoplasms [unspecific] 19887902 C80.1 D009369 miR-17-5p has initially been linked to tumorigenesis other hsa-mir-17 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-17:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-17 Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-17 Neoplasms [unspecific] 26117336 C80.1 D009369 Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. other hsa-mir-17 Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-17 Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-17 Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-17 Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-17 Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-17 Neoplasms [unspecific] 27577994 C80.1 D009369 miR-17-5p is at the crossroads of aging, longevity and cancer and might represent a promising biomarker or even therapeutic tool and target in this context other hsa-mir-17 Neoplasms [unspecific] 27780637 C80.1 D009369 MiR-106a: Promising biomarker for cancer. other hsa-mir-18 Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-18 Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-18 Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-18 Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-18 Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-181a-1 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-181a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-181a-2 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-181a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-181b Neoplasms [unspecific] 29601548 C80.1 D009369 the NF-κB-miR-146 and NF-κB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-κB-miR-21 and NF-κB-miR-181b-2 amplifying loops link inflammation to cancer other hsa-mir-183 Neoplasms [unspecific] 25856466 C80.1 D009369 Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]. other hsa-mir-184 Neoplasms [unspecific] 19546886 C80.1 D009369 laryngeal carcinoma, upregulated; control of the G1-S phase transition;regulate BTG2, a cell cycle gene other hsa-mir-18a Neoplasms [unspecific] 18922889 C80.1 D009369 miR-18a: key modulators of TGFbeta signaling other hsa-mir-18a Neoplasms [unspecific] 19887902 C80.1 D009369 has initially been linked to tumorigenesis other hsa-mir-18a Neoplasms [unspecific] 20144731 C80.1 D009369 miR-18a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-18a Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-19 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-190 Neoplasms [unspecific] 23863200 C80.1 D009369 Transcriptional changes induced by the tumor dormancy-associated microRNA-190. other hsa-mir-192 Neoplasms [unspecific] 21128228 C80.1 D009369 The meta-analysis also revealed some novel tumor-related miRNAs such as hsa-miR-144, hsa-miR-130b, hsa-miR-132, hsa-miR-154, hsa-miR-192 and hsa-miR-345 other hsa-mir-193a Neoplasms [unspecific] 25826780 C80.1 D009369 Our findings have provided new insights into mechanisms of CIK cells production and tumor cytotoxic function, and shed light on their safety for clinical trial. other hsa-mir-195 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-195 Neoplasms [unspecific] 27572273 C80.1 D009369 MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways. other hsa-mir-199a-1 Neoplasms [unspecific] 23354452 C80.1 D009369 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines other hsa-mir-199a-1 Neoplasms [unspecific] 23437196 C80.1 D009369 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1ж┿pathway. other hsa-mir-199a-2 Neoplasms [unspecific] 23354452 C80.1 D009369 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines other hsa-mir-199a-2 Neoplasms [unspecific] 23437196 C80.1 D009369 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1ж┿pathway. other hsa-mir-199b Neoplasms [unspecific] 23354452 C80.1 D009369 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines other hsa-mir-19a Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-19a Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-19a Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-19a Neoplasms [unspecific] 18922889 C80.1 D009369 miR-19a: key modulators of TGFbeta signaling other hsa-mir-19a Neoplasms [unspecific] 19887902 C80.1 D009369 has initially been linked to tumorigenesis other hsa-mir-19a Neoplasms [unspecific] 20008935 C80.1 D009369 miR-19 is a key oncogenic component of mir-17-92 other hsa-mir-19a Neoplasms [unspecific] 20144731 C80.1 D009369 miR-19a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-19a Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-19a Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-19a Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-19b Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-19b-1 Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-19b-1 Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-19b-1 Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-19b-1 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-19b: key modulators of TGFbeta signaling other hsa-mir-19b-1 Neoplasms [unspecific] 20008935 C80.1 D009369 miR-19 is a key oncogenic component of mir-17-92 other hsa-mir-19b-1 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-19b:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-19b-1 Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-19b-1 Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-19b-1 Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-19b-2 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-19b: key modulators of TGFbeta signaling other hsa-mir-19b-2 Neoplasms [unspecific] 20008935 C80.1 D009369 miR-19 is a key oncogenic component of mir-17-92 other hsa-mir-19b-2 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-19b:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-19b-2 Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-200 Neoplasms [unspecific] 25403569 C80.1 D009369 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. other hsa-mir-200 Neoplasms [unspecific] 26069247 C80.1 D009369 Network-Based Approaches to Understand the Roles of miR-200 and Other microRNAs in Cancer. other hsa-mir-200 Neoplasms [unspecific] 26547426 C80.1 D009369 On the basis of these findings,we believe that this method has great potential for quantitative detection of miRNA in biomedical research and early clinical diagnostics. other hsa-mir-200 Neoplasms [unspecific] 24018975 C80.1 D009369 The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent. other hsa-mir-200 Neoplasms [unspecific] 27837593 C80.1 D009369 the full role of the miR-200 family in cancer progression and metastasis is not completely understood and seems to differ between different tumour types and different cellular backgrounds other hsa-mir-200a Neoplasms [unspecific] 21237487 C80.1 D009369 Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition. other hsa-mir-200a Neoplasms [unspecific] 18381893 C80.1 D009369 the epithelial-to-mesenchymal transition other hsa-mir-200a Neoplasms [unspecific] 19221491 C80.1 D009369 miR-200: guardians against pluripotency and cancer progression other hsa-mir-200a Neoplasms [unspecific] 25586904 C80.1 D009369 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. other hsa-mir-200a Neoplasms [unspecific] 18829540 C80.1 D009369 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. other hsa-mir-200a Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-200a Neoplasms [unspecific] 27497669 C80.1 D009369 In conclusion, LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. other hsa-mir-200b Neoplasms [unspecific] 21237487 C80.1 D009369 Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition. other hsa-mir-200b Neoplasms [unspecific] 18381893 C80.1 D009369 the epithelial-to-mesenchymal transition other hsa-mir-200b Neoplasms [unspecific] 19221491 C80.1 D009369 miR-200: guardians against pluripotency and cancer progression other hsa-mir-200b Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-200b Neoplasms [unspecific] 25586904 C80.1 D009369 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. other hsa-mir-200b Neoplasms [unspecific] 18829540 C80.1 D009369 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. other hsa-mir-200b Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-200c Neoplasms [unspecific] 25808651 C80.1 D009369 A Comprehensive Review on miR-200c, A Promising Cancer Biomarker with Therapeutic Potential. other hsa-mir-200c Neoplasms [unspecific] 26334100 C80.1 D009369 In summary, TKS5 and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1/miR-200 feedback loop. other hsa-mir-200c Neoplasms [unspecific] 25759134 C80.1 D009369 we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines. other hsa-mir-200c Neoplasms [unspecific] 21237487 C80.1 D009369 Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition. other hsa-mir-200c Neoplasms [unspecific] 23806972 C80.1 D009369 Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles. other hsa-mir-200c Neoplasms [unspecific] 18381893 C80.1 D009369 the epithelial-to-mesenchymal transition other hsa-mir-200c Neoplasms [unspecific] 19221491 C80.1 D009369 miR-200: guardians against pluripotency and cancer progression other hsa-mir-200c Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-200c Neoplasms [unspecific] 25586904 C80.1 D009369 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. other hsa-mir-200c Neoplasms [unspecific] 27094812 C80.1 D009369 miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis. other hsa-mir-200c Neoplasms [unspecific] 18829540 C80.1 D009369 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. other hsa-mir-200c Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-200c Neoplasms [unspecific] 29029445 C80.1 D009369 MicroRNA-200c increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. other hsa-mir-202 Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-mir-205 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-205 Neoplasms [unspecific] 21237487 C80.1 D009369 Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition. other hsa-mir-205 Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-205 Neoplasms [unspecific] 25586904 C80.1 D009369 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. other hsa-mir-205 Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-206 Neoplasms [unspecific] 26138095 C80.1 D009369 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-208 Neoplasms [unspecific] 25899823 C80.1 D009369 Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications. other hsa-mir-20a Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-20a Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-20a Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-20a Neoplasms [unspecific] 18922889 C80.1 D009369 miR-20a: key modulators of TGFbeta signaling other hsa-mir-20a Neoplasms [unspecific] 19887902 C80.1 D009369 has initially been linked to tumorigenesis other hsa-mir-20a Neoplasms [unspecific] 20144731 C80.1 D009369 miR-20a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-20a Neoplasms [unspecific] 20227518 C80.1 D009369 mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-20a Neoplasms [unspecific] 26117336 C80.1 D009369 Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. other hsa-mir-20a Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-20a Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-20a Neoplasms [unspecific] 24732804 C80.1 D009369 Decreased expression of miR-27a/miR-20a:miR-17-5p by PEITC-induced ROS is a key step in triggering the miR-ZBTB Sp cascade leading to downregulation of Sp TFs, and this is due to ROS-dependent epigenetic effects associated with genome-wide shifts in repressor complexes, resulting in decreased expression of Myc and the Myc-regulated miRs. other hsa-mir-20a Neoplasms [unspecific] 24969314 C80.1 D009369 Furthermore, we demonstrated that upregulation of the miR-17-92 cluster (miR-20a/miR-17-5p) is involved in the regulation of E2F1-mediated negative feedback of the c-Myc/hTERT pathway. other hsa-mir-20a Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-20b Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-21 Neoplasms [unspecific] 24912785 C80.1 D009369 Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. other hsa-mir-21 Neoplasms [unspecific] 25049417 C80.1 D009369 PAPD5 and PARN mediate degradation of oncogenic miRNA miR-21 through a tailing and trimming process, and that this pathway is disrupted in cancer and other proliferative diseases. other hsa-mir-21 Neoplasms [unspecific] 25550434 C80.1 D009369 ESCRT-I complex in the regulation of productive free uptake of anti-miRs and reveal potential avenues for improving oligonucleotide free uptake by cancer cells. other hsa-mir-21 Neoplasms [unspecific] 25943710 C80.1 D009369 We believe that this proposed sensitive and specific assay has great potential as a quantification method for miRNA detection in biomedical research and clinical diagnosis. other hsa-mir-21 Neoplasms [unspecific] 26156753 C80.1 D009369 This is the first study to demonstrate that kallistatin's heparin-binding site is crucial for preventing TGF-β-induced miR-21 and oxidative stress, while its active site is key for stimulating the expression of antioxidant genes via interaction with an endothelial surface tyrosine kinase.These findings reveal novel mechanisms of kallistatin in protection against fibrosis and cancer by suppressing EndMT. other hsa-mir-21 Neoplasms [unspecific] 26191606 C80.1 D009369 The activated single-stranded DC can project the LAA headgroup into the hCA-II active site and is a robust hCA-II inhibitor (K(i) of 3.12 μM). This work may spur research into developing new classes of cancer selective protein inhibitors. other hsa-mir-21 Neoplasms [unspecific] 26220158 C80.1 D009369 preliminary mechanism of action studies propose a different mode of action compared to previously reported miR-21 inhibitors, thus affording a new chemical probe for future studies. other hsa-mir-21 Neoplasms [unspecific] 20219416 C80.1 D009369 miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines other hsa-mir-21 Neoplasms [unspecific] 20335152 C80.1 D009369 Expression of microRNA-21 in ovarian epithelial carcinoma and its clinical significance other hsa-mir-21 Neoplasms [unspecific] 23784029 C80.1 D009369 MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation. other hsa-mir-21 Neoplasms [unspecific] 25149066 C80.1 D009369 miR-21-3p is a positive regulator of L1CAM in several human carcinomas. other hsa-mir-21 Neoplasms [unspecific] 25376700 C80.1 D009369 MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis. other hsa-mir-21 Neoplasms [unspecific] 26271820 C80.1 D009369 MicroRNA-Responsive Cancer Cell Imaging and Therapy with Functionalized Gold Nanoprobe. other hsa-mir-21 Neoplasms [unspecific] 19073608 C80.1 D009369 miR-21: coordinately regulate EGFR signaling in multiple human cancer cell types other hsa-mir-21 Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-21 Neoplasms [unspecific] 20404348 C80.1 D009369 miR-21:function of AKT by which it inhibits apoptosis through miR-21-dependent suppression of FasL other hsa-mir-21 Neoplasms [unspecific] 26101800 C80.1 D009369 The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. other hsa-mir-21 Neoplasms [unspecific] 24041029 C80.1 D009369 Here we summarize current knowledge on miR-21 functions in human cancers and discuss how this finding provides insight into the role of miR-21 as an oncogenic regulator in stem/progenitor cell populations of human cancers. other hsa-mir-21 Neoplasms [unspecific] 23811941 C80.1 D009369 AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression. other hsa-mir-21 Neoplasms [unspecific] 25979949 C80.1 D009369 Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression. other hsa-mir-21 Neoplasms [unspecific] 26189797 C80.1 D009369 RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4. other hsa-mir-21 Neoplasms [unspecific] 26503645 C80.1 D009369 Therefore,this study presents an improved method with shorten time to prepare a (99m)Tc radiolabeled AMO. In addition, it supports the role of (99m)Tc-AMO for noninvasive visualization of miR-21 in malignant tumors. other hsa-mir-21 Neoplasms [unspecific] 25445583 C80.1 D009369 Further, during the transformation of HBE cells, inhibition of miR-21 with an miR-21 inhibitor increased levels of PDCD4, an inhibitor of neoplastic transformation; other hsa-mir-21 Neoplasms [unspecific] 26610525 C80.1 D009369 induction of miR-21 by type I IFN other hsa-mir-21 Neoplasms [unspecific] 24507038 C80.1 D009369 Our results demonstrated that HIF-1伪 could significantly upregulate 伪-smooth muscle actin expression, and reduced the E-cadherin expression in HK-2 cells during I/R injury. Moreover, miR-21 expression had a positive correlation with HIF-1伪 in this process. other hsa-mir-21 Neoplasms [unspecific] 26716902 C80.1 D009369 LIF induces miR-21 expression through the activation of STAT3. other hsa-mir-21 Neoplasms [unspecific] 18384814 C80.1 D009369 Since exogenous miR-21 expression moderately induced endogenous miR-21, an evolutionarily conserved double-negative feedback regulation would be operating as a mechanism to sustain miR-21 expression. other hsa-mir-21 Neoplasms [unspecific] 27992999 C80.1 D009369 Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21. other hsa-mir-21 Neoplasms [unspecific] 28302473 C80.1 D009369 Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21. other hsa-mir-21 Neoplasms [unspecific] 28346427 C80.1 D009369 MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. other hsa-mir-21 Neoplasms [unspecific] 28427524 C80.1 D009369 Kallistatin suppresses cancer development by multi-factorial actions. other hsa-mir-21 Neoplasms [unspecific] 29601548 C80.1 D009369 the NF-κB-miR-146 and NF-κB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-κB-miR-21 and NF-κB-miR-181b-3 amplifying loops link inflammation to cancer other hsa-mir-21 Neoplasms [unspecific] 29642568 C80.1 D009369 Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin other hsa-mir-210 Neoplasms [unspecific] 24909053 C80.1 D009369 Multiple functions of hypoxia-regulated miR-210 in cancer. other hsa-mir-210 Neoplasms [unspecific] 25809609 C80.1 D009369 The role of hypoxia-induced miR-210 in cancer progression. other hsa-mir-210 Neoplasms [unspecific] 24098326 C80.1 D009369 hypoxia related mir-210 and apoptosis-related mir-296-5p in the cancer mechanisms other hsa-mir-210 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-210 Neoplasms [unspecific] 26446394 C80.1 D009369 Potential Role of MicroRNA-210 as Biomarker in Human Cancers Detection: A Meta-Analysis. other hsa-mir-210 Neoplasms [unspecific] 20237418 C80.1 D009369 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state other hsa-mir-210 Neoplasms [unspecific] 23173806 C80.1 D009369 Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer other hsa-mir-210 Neoplasms [unspecific] 24586608 C80.1 D009369 This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant. other hsa-mir-210 Neoplasms [unspecific] 28036268 C80.1 D009369 Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate. other hsa-mir-210 Neoplasms [unspecific] 28046107 C80.1 D009369 RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature. other hsa-mir-210 Neoplasms [unspecific] 28240549 C80.1 D009369 Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. other hsa-mir-214 Neoplasms [unspecific] 25223704 C80.1 D009369 Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. other hsa-mir-214 Neoplasms [unspecific] 20219416 C80.1 D009369 miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines other hsa-mir-214 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-214:miR-34C and miR-214 as Damage Associated Molecular Pattern Molecules-associated miRs other hsa-mir-214 Neoplasms [unspecific] 25364765 C80.1 D009369 By contrast, miR-24, miR-125b, miR-195, and miR-214 function as oncogenic or tumor suppressor miRNAs in a cancer (sub)type-dependent manner. other hsa-mir-215 Neoplasms [unspecific] 25984907 C80.1 D009369 This potential path highlights the crucial role of BMP2,hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis. other hsa-mir-218 Neoplasms [unspecific] 25940608 C80.1 D009369 A feedback loop between c-Src and miR-218 was revealed where c-Src inhibits transcription of SLIT2, which intronically hosts miR-218. These results show a novel regulatory pathway for RPTPα-c-Src signalling. other hsa-mir-218 Neoplasms [unspecific] 26111662 C80.1 D009369 Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. other hsa-mir-218-1 Neoplasms [unspecific] 23060446 C80.1 D009369 miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells other hsa-mir-218-2 Neoplasms [unspecific] 23060446 C80.1 D009369 miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells other hsa-mir-219 Neoplasms [unspecific] 18075311 C80.1 D009369 In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs. other hsa-mir-22 Neoplasms [unspecific] 21502362 C80.1 D009369 miR-22 represses cancer progression by inducing cellular senescence. other hsa-mir-22 Neoplasms [unspecific] 20523723 C80.1 D009369 Our results suggest that miR-22 acts to fine-tune the dynamics of PTEN/AKT/FoxO1 pathway. other hsa-mir-221 Neoplasms [unspecific] 20406109 C80.1 D009369 miR-221:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs other hsa-mir-221 Neoplasms [unspecific] 20461750 C80.1 D009369 MiR-221:MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma other hsa-mir-221 Neoplasms [unspecific] 21481725 C80.1 D009369 miRNA-221/-222 control radiation sensitivity by regulating the PTEN/AKT pathway and can be explored as novel targets for radiosensitization. other hsa-mir-221 Neoplasms [unspecific] 26959615 C80.1 D009369 biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies other hsa-mir-222 Neoplasms [unspecific] 20406109 C80.1 D009369 miR-222:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs other hsa-mir-222 Neoplasms [unspecific] 20461750 C80.1 D009369 MiR-222:MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma other hsa-mir-222 Neoplasms [unspecific] 20525881 C80.1 D009369 miR-222:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-222 Neoplasms [unspecific] 21481725 C80.1 D009369 miRNA-221/-222 control radiation sensitivity by regulating the PTEN/AKT pathway and can be explored as novel targets for radiosensitization. other hsa-mir-222 Neoplasms [unspecific] 26959615 C80.1 D009369 biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies other hsa-mir-223 Neoplasms [unspecific] 23772809 C80.1 D009369 mir-223: infection, inflammation and cancer. other hsa-mir-223 Neoplasms [unspecific] 28197019 C80.1 D009369 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. other hsa-mir-224 Neoplasms [unspecific] 20525881 C80.1 D009369 miR-224:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-23a Neoplasms [unspecific] 25347474 C80.1 D009369 Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. other hsa-mir-23a Neoplasms [unspecific] 25429623 C80.1 D009369 HSP70 could be beneficial to tumor cells by helping to maintain the expression of oncogenic miRNAs under conditions of cellular stress. other hsa-mir-23a Neoplasms [unspecific] 20219416 C80.1 D009369 miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines other hsa-mir-23a Neoplasms [unspecific] 20086171 C80.1 D009369 In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b. other hsa-mir-23a Neoplasms [unspecific] 29387410 C80.1 D009369 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression other hsa-mir-23b Neoplasms [unspecific] 24755453 C80.1 D009369 Regulation of miR-23b expression and its dual role on ROS production and tumour development. other hsa-mir-23b Neoplasms [unspecific] 27040799 C80.1 D009369 Among down-regulators of PRODH/POX is an oncogenic transcription factor c-MYC and miR-23b*. other hsa-mir-23b Neoplasms [unspecific] 20086171 C80.1 D009369 In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b. other hsa-mir-24 Neoplasms [unspecific] 25984907 C80.1 D009369 This potential path highlights the crucial role of BMP2,hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis. other hsa-mir-24 Neoplasms [unspecific] 25364765 C80.1 D009369 By contrast, miR-24, miR-125b, miR-195, and miR-214 function as oncogenic or tumor suppressor miRNAs in a cancer (sub)type-dependent manner. other hsa-mir-24 Neoplasms [unspecific] 28500171 C80.1 D009369 Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. other hsa-mir-24 Neoplasms [unspecific] 26967561 C80.1 D009369 melatonin can inhibit cell proliferation and migration, at least in part, by downregulating miR-24. other hsa-mir-24-2 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-24-2 Neoplasms [unspecific] 29387410 C80.1 D009369 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression other hsa-mir-25 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-25: key modulators of TGFbeta signaling other hsa-mir-25 Neoplasms [unspecific] 23246404 C80.1 D009369 Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25 other hsa-mir-25 Neoplasms [unspecific] 25672882 C80.1 D009369 miR-25 is suggested to be important in TNF-α-induced abnormal proliferation of vascular smooth muscle cells (VSMCs). other hsa-mir-27a Neoplasms [unspecific] 29387410 C80.1 D009369 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression other hsa-mir-27b Neoplasms [unspecific] 26473412 C80.1 D009369 These findings show that miR-27b functions as a tumor suppressor by controlling ARFGEF1 and the paxillin/c-Src circuit at focal adhesions. other hsa-mir-28 Neoplasms [unspecific] 25617309 C80.1 D009369 miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation. other hsa-mir-29 Neoplasms [unspecific] 24573597 C80.1 D009369 Our review highlights the diverse relationship between miR-29 and cancer (particularly digestive system neoplasms). other hsa-mir-29 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-29 Neoplasms [unspecific] 23857059 C80.1 D009369 miR-29 represses the activities of DNA methyltransferases and DNA demethylases. other hsa-mir-29 Neoplasms [unspecific] 23901138 C80.1 D009369 miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. other hsa-mir-296 Neoplasms [unspecific] 24098326 C80.1 D009369 hypoxia related mir-210 and apoptosis-related mir-296-5p in the cancer mechanisms other hsa-mir-29a Neoplasms [unspecific] 23401122 C80.1 D009369 miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer other hsa-mir-29a Neoplasms [unspecific] 29217524 C80.1 D009369 we discussed the functions of miR-29a and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide additional insight to develop a novel therapeutic strategy other hsa-mir-29b Neoplasms [unspecific] 28185889 C80.1 D009369 MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1. other hsa-mir-29b-1 Neoplasms [unspecific] 20525881 C80.1 D009369 miR-29b:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-29b-1 Neoplasms [unspecific] 23354167 C80.1 D009369 GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression other hsa-mir-29b-2 Neoplasms [unspecific] 20525881 C80.1 D009369 miR-29b:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-29b-2 Neoplasms [unspecific] 23354167 C80.1 D009369 GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression other hsa-mir-29c Neoplasms [unspecific] 23175151 C80.1 D009369 MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression other hsa-mir-302 Neoplasms [unspecific] 24705778 C80.1 D009369 In conclusion, the controversial role of miR-302-367 in different cell types may provide better understanding for its role in stemness level and its antitumorigenicity potential in different contexts. other hsa-mir-302c Neoplasms [unspecific] 23820258 C80.1 D009369 1,25(OH)2D3 facilitates the immuno-attack of NK cells against malignant cells partly through downregulation of miR-302c and miR-520c and hence upregulation of the NKG2D ligands MICA/B and ULBP2. other hsa-mir-30a Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-30d Neoplasms [unspecific] 23274497 C80.1 D009369 mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells other hsa-mir-30e Neoplasms [unspecific] 19593777 C80.1 D009369 association with cancer progression other hsa-mir-31 Neoplasms [unspecific] 25139099 C80.1 D009369 Prognostic role of microRNA-31 in various cancers: a meta-analysis. other hsa-mir-31 Neoplasms [unspecific] 20145132 C80.1 D009369 miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma other hsa-mir-31 Neoplasms [unspecific] 20530680 C80.1 D009369 miR-31:Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis other hsa-mir-31 Neoplasms [unspecific] 21875932 C80.1 D009369 miR-31 is a master regulator of integrins. The expression of miR-31 in cancer cells resulted in a significant repression of these integrin subunits both at the mRNA and protein levels. other hsa-mir-3158 Neoplasms [unspecific] 27919789 C80.1 D009369 Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness. other hsa-mir-330 Neoplasms [unspecific] 26138095 C80.1 D009369 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-335 Neoplasms [unspecific] 20713524 C80.1 D009369 miR-335:miR-335 activates the p53 tumor suppressor pathway to limit cell proliferation and neoplastic cell transformation other hsa-mir-335 Neoplasms [unspecific] 28932769 C80.1 D009369 MicroRNA expression in a phosphaturic mesenchymal tumour. other hsa-mir-34 Neoplasms [unspecific] 24532687 C80.1 D009369 Taken together, our results elucidated the intricate cross-talk between p53 and miR-34 miRNAs and revealed an important tumor suppressor effect generated by this positive feedback loop. other hsa-mir-34 Neoplasms [unspecific] 25486198 C80.1 D009369 identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients. other hsa-mir-34 Neoplasms [unspecific] 25102298 C80.1 D009369 Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis. other hsa-mir-34 Neoplasms [unspecific] 23834144 C80.1 D009369 Functional role of miR-34 family in human cancer. other hsa-mir-342 Neoplasms [unspecific] 26138095 C80.1 D009369 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-34a Neoplasms [unspecific] 24583844 C80.1 D009369 miR-34a/SIRT6 in squamous differentiation and cancer. other hsa-mir-34a Neoplasms [unspecific] 25052958 C80.1 D009369 The well-formulated LPEI-CaPs with lc-miRNA-d have the potential to provide superior miRNA transfection efficiency and inhibition of cancer proliferation. other hsa-mir-34a Neoplasms [unspecific] 25896587 C80.1 D009369 miR-34a plays an important role in the anti-tumor effects of querctin in HCC, miR-34a may be a tiemolecule between the p53 and SIRT1 and is composed of a p53/miR-34a/SIRT1 signal feedback loop, which could enhance apoptosis signal and significantly promote cell apoptosis. other hsa-mir-34a Neoplasms [unspecific] 25939820 C80.1 D009369 Multivalent aptamer-RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells. other hsa-mir-34a Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-34a Neoplasms [unspecific] 24438466 C80.1 D009369 MicroRNA-34a: role in cancer and cardiovascular disease. other hsa-mir-34a Neoplasms [unspecific] 23836017 C80.1 D009369 TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.). other hsa-mir-34a Neoplasms [unspecific] 26718338 C80.1 D009369 MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1. other hsa-mir-34a Neoplasms [unspecific] 20525881 C80.1 D009369 miR-34a:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-34a Neoplasms [unspecific] 23292172 C80.1 D009369 Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model other hsa-mir-34a Neoplasms [unspecific] 25579512 C80.1 D009369 Regulatory mechanisms and clinical perspectives of miR-34a in cancer. other hsa-mir-34a Neoplasms [unspecific] 25220161 C80.1 D009369 Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. other hsa-mir-34a Neoplasms [unspecific] 19074875 C80.1 D009369 Accordingly, the tumor suppressor p53 up-regulates miR-34a, a microRNA that contributes to apoptosis and acute senescence. other hsa-mir-34a Neoplasms [unspecific] 26648462 C80.1 D009369 MiR-34a is associated with G1 cell cycle arrest, senescence and apoptosis, thereby possessing a tumor suppressor activity. other hsa-mir-34a Neoplasms [unspecific] 17656095 C80.1 D009369 Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers. other hsa-mir-34a Neoplasms [unspecific] 28119089 C80.1 D009369 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. other hsa-mir-34a Neoplasms [unspecific] 28511876 C80.1 D009369 Chondroitin sulfate-functionalized polyamidoamine as a tumor-targeted carrier for miR-34a delivery. other hsa-mir-34a Neoplasms [unspecific] 28657476 C80.1 D009369 Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells. other hsa-mir-34b Neoplasms [unspecific] 25227823 C80.1 D009369 Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis. other hsa-mir-34b Neoplasms [unspecific] 23314612 C80.1 D009369 MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met other hsa-mir-34b Neoplasms [unspecific] 17656095 C80.1 D009369 Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers. other hsa-mir-34c Neoplasms [unspecific] 25227823 C80.1 D009369 Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis. other hsa-mir-34c Neoplasms [unspecific] 20144731 C80.1 D009369 miR-34c:miR-34C and miR-214 as Damage Associated Molecular Pattern Molecules-associated miRs other hsa-mir-34c Neoplasms [unspecific] 23922103 C80.1 D009369 These findings provide a novel molecular mechanism of MET regulation in PCa and contribute to the increasing evidence that miR-34c has a key tumour suppressive role in PCa. other hsa-mir-34c Neoplasms [unspecific] 17656095 C80.1 D009369 Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers. other hsa-mir-365-2 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-370 Neoplasms [unspecific] 17621267 C80.1 D009369 Thus, IL-6 may contribute to tumor growth by modulation of expression of selected miRNAs, such as miR-370. These studies define a mechanism by which inflammation-associated cytokines can epigenetically modulate gene expression and directly contribute to tumor biology. other hsa-mir-371 Neoplasms [unspecific] 25941115 C80.1 D009369 MiR-371-373 cluster acts as a tumor-suppressor-miR and promotes cell cycle arrest in unrestricted somatic stem cells. other hsa-mir-372 Neoplasms [unspecific] 17028596 C80.1 D009369 mir-372/373 shown to be oncogenes cooperating with Ras (Voorhoeve et al., 2006) other hsa-mir-372 Neoplasms [unspecific] 29374231 C80.1 D009369 Modulation of oncogenic miRNA biogenesis using functionalized polyamines other hsa-mir-373 Neoplasms [unspecific] 25941115 C80.1 D009369 MiR-371-373 cluster acts as a tumor-suppressor-miR and promotes cell cycle arrest in unrestricted somatic stem cells. other hsa-mir-373 Neoplasms [unspecific] 17028596 C80.1 D009369 mir-372/373 shown to be oncogenes cooperating with Ras (Voorhoeve et al., 2006) other hsa-mir-375 Neoplasms [unspecific] 24166096 C80.1 D009369 The emerging role of miR-375 in cancer. other hsa-mir-375 Neoplasms [unspecific] 24708873 C80.1 D009369 Taken together, miR-375-mediated suppression of multiple oncogenic components in HPV-associated carcinogenesis generates a cumulative biological response to rescue key tumor suppressors and diminish telomerase activity, which results in cell cycle arrest and cell proliferation inhibition. other hsa-mir-375 Neoplasms [unspecific] 25195536 C80.1 D009369 The CMAP database is a useful tool for identifying compounds affecting the same molecular pathways, particularly products that are difficult to apply via practical approaches, such as microRNAs. other hsa-mir-375 Neoplasms [unspecific] 27844328 C80.1 D009369 Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets. other hsa-mir-378a Neoplasms [unspecific] 21242960 C80.1 D009369 Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. other hsa-mir-378a Neoplasms [unspecific] 24651706 C80.1 D009369 A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence. other hsa-mir-381 Neoplasms [unspecific] 24303078 C80.1 D009369 Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. other hsa-mir-421 Neoplasms [unspecific] 24716910 C80.1 D009369 MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis. other hsa-mir-424 Neoplasms [unspecific] 24967963 C80.1 D009369 Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis. other hsa-mir-424 Neoplasms [unspecific] 25716682 C80.1 D009369 TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. other hsa-mir-429 Neoplasms [unspecific] 25403569 C80.1 D009369 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. other hsa-mir-429 Neoplasms [unspecific] 18829540 C80.1 D009369 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. other hsa-mir-429 Neoplasms [unspecific] 18927505 C80.1 D009369 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. other hsa-mir-449a Neoplasms [unspecific] 25760387 C80.1 D009369 microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. other hsa-mir-451 Neoplasms [unspecific] 26257001 C80.1 D009369 Both, energy-conserving metabolic shift and resource-seeking behavioral change require brain tumor cell to shut down miR-451, while forced expression of miR-451 during stress leads to cytotoxicity [3]. The AMPK-dependent inactivation of the OCT1 transcriptional activator of miR-451 helps brain tumor cells to escape from metabolically stressful events/locations. MiR-451 thus provides an example of a molecule that is not deregulated in brain tumor cells, but is instead finely regulated by promoting or suppressing brain tumor cell phenotypes based on microenvironmental contexts. other hsa-mir-455 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-455 Neoplasms [unspecific] 28004230 C80.1 D009369 In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences. other hsa-mir-4728 Neoplasms [unspecific] 25950472 C80.1 D009369 ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. other hsa-mir-483 Neoplasms [unspecific] 24298054 C80.1 D009369 The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. other hsa-mir-493 Neoplasms [unspecific] 27956702 C80.1 D009369 Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis. other hsa-mir-494 Neoplasms [unspecific] 25781916 C80.1 D009369 Specifically we have linked miR-134, miR-145, miR-146b-5p, miR-432 and miR-494 to the regulation of both apoptotic and anti-apoptotic genes expressed as a function of EGF treatment. other hsa-mir-495 Neoplasms [unspecific] 24303078 C80.1 D009369 Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. other hsa-mir-498 Neoplasms [unspecific] 23055531 C80.1 D009369 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498 other hsa-mir-499 Neoplasms [unspecific] 24593893 C80.1 D009369 These results suggest that miR-499 delivered by the present system has excellent potency to treat cancer via integrative anticancer actions. other hsa-mir-501 Neoplasms [unspecific] 25899823 C80.1 D009369 Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications. other hsa-mir-503 Neoplasms [unspecific] 26999740 C80.1 D009369 miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. other hsa-mir-504 Neoplasms [unspecific] 26625740 C80.1 D009369 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. other hsa-mir-511 Neoplasms [unspecific] 28197019 C80.1 D009369 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. other hsa-mir-520b Neoplasms [unspecific] 19109132 C80.1 D009369 miR-520b: miR-520b was induced by IFN-gamma, leading to a reduction in MICA surface protein levels other hsa-mir-520c Neoplasms [unspecific] 23820258 C80.1 D009369 1,25(OH)2D3 facilitates the immuno-attack of NK cells against malignant cells partly through downregulation of miR-302c and miR-520c and hence upregulation of the NKG2D ligands MICA/B and ULBP2. other hsa-mir-520d Neoplasms [unspecific] 25426550 C80.1 D009369 miR-520d-5p leads to reduced proliferation of tumor cells, and that high levels of miR-520d-5p correlate with higher survival rates of cancer patients. other hsa-mir-520h Neoplasms [unspecific] 20501832 C80.1 D009369 miR-520h:Downregulation of microRNA miR-520h by E1A contributes to anticancer activity other hsa-mir-520h Neoplasms [unspecific] 25169894 C80.1 D009369 PD-miRNAs that are currently implicated as cancer biomarkers or diagnostics: hsa-mir-202, hsa-mir-423, hsa-mir-196a-2, hsa-mir-520h, hsa-mir-647, hsa-mir-943, and hsa-mir-1908. other hsa-mir-532 Neoplasms [unspecific] 20525881 C80.1 D009369 miR-532:five miRNAs that negatively control cell proliferation, including miRNA-34a other hsa-mir-542 Neoplasms [unspecific] 21756784 C80.1 D009369 miR-542-3p affects carcinogenesis induced by anti-benzo(a) pyrene-7,8-diol-9,10-epoxide other hsa-mir-548 Neoplasms [unspecific] 24556720 C80.1 D009369 Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene. other hsa-mir-630 Neoplasms [unspecific] 24909689 C80.1 D009369 E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells. other hsa-mir-638 Neoplasms [unspecific] 23155245 C80.1 D009369 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells other hsa-mir-650 Neoplasms [unspecific] 24716910 C80.1 D009369 MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis. other hsa-mir-663a Neoplasms [unspecific] 23155245 C80.1 D009369 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells other hsa-mir-663b Neoplasms [unspecific] 23155245 C80.1 D009369 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells other hsa-mir-7 Neoplasms [unspecific] 24014594 C80.1 D009369 we review the current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways and discuss possible models explaining the relevance of coexpressing miR-7 along with a circRNA inhibitor. c-mir-221-3p,c-mir-223-3p other hsa-mir-7-1 Neoplasms [unspecific] 19073608 C80.1 D009369 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types other hsa-mir-7-1 Neoplasms [unspecific] 21592959 C80.1 D009369 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. other hsa-mir-7-2 Neoplasms [unspecific] 19073608 C80.1 D009369 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types other hsa-mir-7-2 Neoplasms [unspecific] 21592959 C80.1 D009369 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. other hsa-mir-7-3 Neoplasms [unspecific] 19073608 C80.1 D009369 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types other hsa-mir-7-3 Neoplasms [unspecific] 21592959 C80.1 D009369 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. other hsa-mir-9 Neoplasms [unspecific] 25375090 C80.1 D009369 MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. other hsa-mir-92 Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-92-1 Neoplasms [unspecific] 25887381 C80.1 D009369 Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. other hsa-mir-92-1 Neoplasms [unspecific] 26479035 C80.1 D009369 Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients other hsa-mir-92-1 Neoplasms [unspecific] 26545119 C80.1 D009369 In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-β signaling pathway. Manipulation of the TGF-β pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS. other hsa-mir-92-1 Neoplasms [unspecific] 23550645 C80.1 D009369 Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. other hsa-mir-92-1 Neoplasms [unspecific] 19066217 C80.1 D009369 Using the concept and model prediction of a "cancer zone," the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc. other hsa-mir-92a Neoplasms [unspecific] 29574928 C80.1 D009369 Our results show that miR-92a possesses a cell-type dependent function other hsa-mir-92a-1 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-92a: key modulators of TGFbeta signaling other hsa-mir-92a-1 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-92a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-92a-1 Neoplasms [unspecific] 20227518 C80.1 D009369 miR-92a:mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-92a-2 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-92a: key modulators of TGFbeta signaling other hsa-mir-92a-2 Neoplasms [unspecific] 20144731 C80.1 D009369 miR-92a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a other hsa-mir-92a-2 Neoplasms [unspecific] 20227518 C80.1 D009369 miR-92a:mir-17-92, a cluster of miRNAs in the midst of the cancer network other hsa-mir-93 Neoplasms [unspecific] 24220575 C80.1 D009369 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. other hsa-mir-93 Neoplasms [unspecific] 18922889 C80.1 D009369 miR-93: key modulators of TGFbeta signaling other hsa-mir-93 Neoplasms [unspecific] 20878079 C80.1 D009369 The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy. other hsa-mir-940 Neoplasms [unspecific] 24675421 C80.1 D009369 Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. other hsa-mir-98 Neoplasms [unspecific] 25856466 C80.1 D009369 Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]. other hsa-mir-98 Neoplasms [unspecific] 22129484 C80.1 D009369 The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness. other hsa-mir-99b Neoplasms [unspecific] 26138095 C80.1 D009369 These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers. other hsa-mir-30a Nephrotic Syndrome 26345917 urinary system disease DOID:1184 N04 D009404 PS256300 HP:0000100 Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance. other hsa-let-7f Nervous System Diseases [unspecific] 25406171 C72.9 D009422 EW-induced mitochondrial respiratory suppression was exacerbated by TSA treatment in a manner that was attenuated by let-7f antagomir cotreatment. other hsa-mir-124 Nervous System Diseases [unspecific] 26041995 C72.9 D009422 the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident other hsa-mir-132 Nervous System Diseases [unspecific] 25351997 C72.9 D009422 Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner. other hsa-mir-138 Nervous System Diseases [unspecific] 26026282 C72.9 D009422 Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD). other hsa-mir-219 Nervous System Diseases [unspecific] 26026282 C72.9 D009422 Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD). other hsa-mir-219 Nervous System Diseases [unspecific] 19196972 C72.9 D009422 miR-219: MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction other hsa-mir-302 Nervous System Diseases [unspecific] 26030913 C72.9 D009422 These results show that neuroblasts can be generated directly from adult human and mouse astrocytes by miR-302/367-driven induction. This approach seems promising for converting glial scar cells into neuroblasts in a wide range of neurological diseases. other hsa-mir-338 Nervous System Diseases [unspecific] 26026282 C72.9 D009422 Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD). other hsa-mir-367 Nervous System Diseases [unspecific] 26030913 C72.9 D009422 These results show that neuroblasts can be generated directly from adult human and mouse astrocytes by miR-302/367-driven induction. This approach seems promising for converting glial scar cells into neuroblasts in a wide range of neurological diseases. other hsa-mir-9 Nervous System Diseases [unspecific] 26026282 C72.9 D009422 Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD). other hsa-mir-21 Neurilemmoma 29298734 disease of cellular proliferation DOID:3192 D36.10 D009442 Ailanthone promotes human vestibular schwannoma cells apoptosis and autophagy by down-regulation of miR-21 other hsa-let-7 Neuroblastoma 27383785 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. other hsa-let-7b Neuroblastoma 25779425 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Enterovirus 71 induces apoptosis of SH-SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression. other hsa-mir-1 Neuroblastoma 23022474 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504. other hsa-mir-106a Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-124 Neuroblastoma 29073265 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MiRNA-124 is a link between measles virus persistent infection and cell division of human neuroblastoma cells. other hsa-mir-125b-1 Neuroblastoma 26480000 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells. other hsa-mir-128 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-128-1 Neuroblastoma 19713529 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 reduce cell motility and invasiveness other hsa-mir-128-2 Neuroblastoma 19713529 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 reduce cell motility and invasiveness other hsa-mir-130a Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-132 Neuroblastoma 27374124 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. other hsa-mir-137 Neuroblastoma 28223126 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137. other hsa-mir-17 Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-17 Neuroblastoma 20980091 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Mir-21, an established oncomir in a variety of cancer types, became strongly up-regulated upon MYCN knockdown and the subsequent differentiation. other hsa-mir-17 Neuroblastoma 27396325 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Here, we demonstrate that this microRNA (miRNA) cluster selectively targets several members of the nuclear hormone receptor (NHR) superfamily, and we present a unique NHR signature associated with the survival of neuroblastoma patients. other hsa-mir-18 Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-181a Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-181a Neuroblastoma 28365714 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MicroRNA-181a Regulates Apoptosis and Autophagy Process in Parkinson's Disease by Inhibiting p38 Mitogen-Activated Protein Kinase (MAPK)/c-Jun N-Terminal Kinases (JNK) Signaling Pathways. other hsa-mir-181a Neuroblastoma 29426375 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Triptolide inhibits proliferation and migration of human neuroblastoma SH-SY5Y cells by up-regulating microRNA-181a other hsa-mir-183 Neuroblastoma 23625969 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. other hsa-mir-18a Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-18a Neuroblastoma 27895778 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Regulatory network analysis of genes and microRNAs in human hepatoblastoma. other hsa-mir-190a Neuroblastoma 23245204 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway other hsa-mir-190b Neuroblastoma 23245204 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway other hsa-mir-19a Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-19b Neuroblastoma 27492819 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Suppression of miR-19b may enhance the cytotoxic effects of mTOR inhibitors in neuroblastoma cells other hsa-mir-19b-1 Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-204 Neuroblastoma 22892391 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome. other hsa-mir-20a Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-21 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-21 Neuroblastoma 28599474 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Reduction of miR-21 induces SK-N-SH cell apoptosis and inhibits proliferation via PTEN/PDCD4. other hsa-mir-21 Neuroblastoma 29635890 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MiR-21 attenuates apoptosis-triggered by amyloid-β via modulating PDCD4/PI3K/AKT/GSK-3β pathway in SH-SY5Y cells other hsa-mir-212 Neuroblastoma 27374124 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. other hsa-mir-218 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-221 Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-25 Neuroblastoma 27374124 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. other hsa-mir-30a Neuroblastoma 25149854 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Lithium/Valproic acid combination and L-glutamate induce similar pattern of changes in the expression of miR-30a-5p in SH-SY5Y neuroblastoma cells. other hsa-mir-335 Neuroblastoma 23806264 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 We report, for the first time, that GRP-R-mediated tumorigenicity and increased metastatic potential in neuroblastoma are regulated, in part, by miR-335 and miR-363. A better understanding of the anti-tumor functions of miRNAs could provide valuable insights to discerning molecular mechanisms responsible for neuroblastoma metastasis. other hsa-mir-337 Neuroblastoma 26084291 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. other hsa-mir-34a Neuroblastoma 21266077 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 This microRNA is a potent tumor suppressor molecule in vivo in neuroblastoma. other hsa-mir-34a Neuroblastoma 17297439 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. other hsa-mir-34a Neuroblastoma 19373781 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Neuroblastoma (NB) is the most common extracranial solid tumor in children below the age of 5 years. miR-34a, located in chromosome band 1p36, has been recently implicated as a tumor suppressor gene in NB. other hsa-mir-34a Neuroblastoma 19461653 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 In this review, the evidence for a role of miR-34a and miR-34b/c in the apoptotic response of normal and tumor cells is surveyed. other hsa-mir-34a Neuroblastoma 22662276 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. other hsa-mir-34a Neuroblastoma 23022474 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504. other hsa-mir-34a Neuroblastoma 23647235 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 using the TANA modified antisense oligonucleotide against miR-34a, intracellular levels of miR-34 can be reduced, and consequently, the expression of its target oncogene V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN) is enhanced. other hsa-mir-34a Neuroblastoma 28145567 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 nanoparticles encapsulating miR‐34a and conjugated to a GD2 antibody facilitated tumor‐specific delivery following systemic administration into tumor bearing mice other hsa-mir-363 Neuroblastoma 23806264 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 We report, for the first time, that GRP-R-mediated tumorigenicity and increased metastatic potential in neuroblastoma are regulated, in part, by miR-335 and miR-363. A better understanding of the anti-tumor functions of miRNAs could provide valuable insights to discerning molecular mechanisms responsible for neuroblastoma metastasis. other hsa-mir-380 Neuroblastoma 20871609 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 In vivo delivery of a miR-380-5p antagonist decreases tumor size in an orthotopic mouse model of neuroblastoma. other hsa-mir-380 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-410 Neuroblastoma 27498840 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 In conclusion, the present study demonstrates that the overexpression of SPARC in combination with radiation reduced tumor angiogenesis by downregulating VEGF-A via miR-410. other hsa-mir-424 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-451 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-504 Neuroblastoma 23022474 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504. other hsa-mir-542 Neuroblastoma 20466808 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 miR-542-5p:the putative tumor suppressive microRNAs, miR-542-5p and miR-628, were expressed in favorable NBs and virtually absent in unfavorable NBs other hsa-mir-542 Neuroblastoma 21310526 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MicroRNA-542-5p as a novel tumor suppressor in neuroblastoma. other hsa-mir-558 Neuroblastoma 25616966 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 miR-558 induces the transcriptional activation of HPSE via the binding site within promoter, thus facilitating the tumorigenesis and aggressiveness of NB. other hsa-mir-558 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-572 Neuroblastoma 27716787 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines. other hsa-mir-628 Neuroblastoma 20466808 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 miR-628:the putative tumor suppressive microRNAs, miR-542-5p and miR-628, were expressed in favorable NBs and virtually absent in unfavorable NBs other hsa-mir-659 Neuroblastoma 25980492 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients. other hsa-mir-663a Neuroblastoma 27716787 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines. other hsa-mir-7 Neuroblastoma 26258008 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Such miRNAs regulate genes involved in cellular processes other hsa-mir-7-1 Neuroblastoma 23192662 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Overexpression of miR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells other hsa-mir-7-2 Neuroblastoma 23192662 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 Overexpression of miR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells other hsa-mir-92-1 Neuroblastoma 17943719 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. other hsa-mir-92a-1 Neuroblastoma 21572098 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. other hsa-mir-92a-2 Neuroblastoma 21572098 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. other hsa-mir-92b Neuroblastoma 21572098 disease of cellular proliferation DOID:769 C74.90 D009447 256700 HP:0003006 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. other hsa-let-7b Neurodegenerative Diseases [unspecific] 20423455 D019636 HP:0002180 Interestingly, both miRNAs are capable of binding directly to TDP-43 in different positions: within the miRNA sequence itself (let-7b) or in the hairpin precursor (miR-663). other hsa-mir-124 Neurodegenerative Diseases [unspecific] 27117821 D019636 HP:0002180 MicroRNAs underlying memory deficits in neurodegenerative disorders. other hsa-mir-132 Neurodegenerative Diseases [unspecific] 27117821 D019636 HP:0002180 MicroRNAs underlying memory deficits in neurodegenerative disorders. other hsa-mir-146a Neurodegenerative Diseases [unspecific] 24917789 D019636 HP:0002180 These findings together with the reduced expression of microRNA (miR)-124, and miR-155, decreased autophagy, enhanced senescence associated beta-galactosidase activity and elevated miR-146a expression, are suggestive that 16 DIV cells mainly correspond to irresponsive/senescent microglia. other hsa-mir-146a Neurodegenerative Diseases [unspecific] 25484882 D019636 HP:0002180 We particularly focus on the role played by miR-146a in the regulation and signaling mediated by one of the main pattern recognition receptors, toll/IL-1 receptors (TLRs). other hsa-mir-328 Neurodegenerative Diseases [unspecific] 26900752 D019636 HP:0002180 These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases other hsa-mir-338 Neurodegenerative Diseases [unspecific] 23979835 D019636 HP:0002180 The EnSCs can differentiate to oligodendrocyte cells by the overexpression of miR-338, and these cells can be used as a unique source for cell therapy of neurodegenerative disease. other hsa-mir-34 Neurodegenerative Diseases [unspecific] 27117821 D019636 HP:0002180 MicroRNAs underlying memory deficits in neurodegenerative disorders. other hsa-mir-4306 Neurodegenerative Diseases [unspecific] 28302480 D019636 HP:0002180 Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease. other hsa-mir-663 Neurodegenerative Diseases [unspecific] 20423455 D019636 HP:0002180 Interestingly, both miRNAs are capable of binding directly to TDP-43 in different positions: within the miRNA sequence itself (let-7b) or in the hairpin precursor (miR-663). other hsa-mir-96 Neurodegenerative Diseases [unspecific] 24304186 D019636 HP:0002180 Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. other hsa-mir-196a Neuroendocrine Tumors 26052033 disease of cellular proliferation DOID:169 C7A D018358 Roles of miR-196a on gene regulation of neuroendocrine tumor cells. other hsa-mir-296 Neurofibromatosis type 2 26923924 genetic disease DOID:8712 Q85.02 C537392 101000 Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p. other hsa-mir-155 Neuroinflammation 24604078 MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. other hsa-mir-155 Neuroinflammation 28139244 MicroRNA 155 and viral-induced neuroinflammation. other hsa-mir-155 Neuroinflammation 29079998 Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155. other hsa-mir-608 Neuroinflammation 28326544 Personalized genetics of the cholinergic blockade of neuroinflammation. other hsa-mir-155 Neuronal Apoptosis-Related Diseases 28831740 Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5. other hsa-mir-124a Neuropathic Pain 27646435 D009437 miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. other hsa-mir-155 Neuropathic Pain 27646435 D009437 miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. other hsa-mir-183 Neuropathic Pain 28572455 D009437 miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. other hsa-mir-196b Neutropenia 19278956 hematopoietic system disease DOID:1227 D70.9 D009503 PS202700 HP:0001875 miR-196b: regulated by Gfi1 other hsa-mir-21 Neutropenia 19278956 hematopoietic system disease DOID:1227 D70.9 D009503 PS202700 HP:0001875 miR-21: regulated by Gfi1 other hsa-mir-183 Non-Sensory Diseases 26170234 the genomic organization and seeming redundancy of the miR-183 family cluster was conserved through 600 million years of evolution other hsa-mir-146a Non-Syndromic Orofacial Clefts 29484780 PS119530 A functional polymorphism in the pre-miR-146a gene is associated with the risk of nonsyndromic orofacial cleft. other hsa-let-7d Obesity 25704235 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPAR纬 expression in 3T3-L1 cells. other hsa-let-7f Obesity 25710930 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 genes modulated in RO-treated cells were found to be validated miRNAs targets, such as let-7f-1, miR-17, and miR-143. other hsa-let-7g Obesity 22614057 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. other hsa-mir-107 Obesity 22645244 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes. other hsa-mir-122 Obesity 25515554 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Elevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity. other hsa-mir-122 Obesity 24165878 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. other hsa-mir-125a Obesity 24901105 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our results support the involvement of miR-125a-3p in regulating the insulin signalling pathway and imply that increased miR- 125a-3p expression in omental adipose tissues may be a characteristic feature of insulin resistance in obese men. other hsa-mir-125a Obesity 26148871 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. other hsa-mir-126 Obesity 25701361 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. other hsa-mir-143 Obesity 19188425 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our results provide the first experimental evidence for miR-103 function in adipose biology. other hsa-mir-146b Obesity 24931160 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity. other hsa-mir-146b Obesity 22393448 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin. other hsa-mir-148a Obesity 27878286 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Obesity‑associated miR‑148a is regulated by cytokines and adipokines via a transcriptional mechanism. other hsa-mir-16 Obesity 25701361 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. other hsa-mir-221 Obesity 23867206 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our results support the link between miR-221 and obesity development as well as obesity related inflammatory status. other hsa-mir-223 Obesity 26962854 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 High-Density Lipoprotein-Associated miR-223 Is Altered after Diet-Induced Weight Loss in Overweight and Obese Males. other hsa-mir-26a Obesity 26107166 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 These results unravel a new mechanism by which bile acid receptor TGR5 activates a miRNA gene expression. other hsa-mir-27a Obesity 25510894 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Correspondingly, the expression of miR-27a and miR-27b were up-regulated by persimmon tannin from Day 2 to Day 8 significantly. other hsa-mir-27b Obesity 25510894 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Correspondingly, the expression of miR-27a and miR-27b were up-regulated by persimmon tannin from Day 2 to Day 8 significantly. other hsa-mir-33 Obesity 24165878 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. other hsa-mir-33a Obesity 25769350 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Deregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome. other hsa-mir-375 Obesity 21291493 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Taken together, these data suggest that miR-375 promotes 3T3-L1 adipocyte differentiation, possibly through modulating the ERK-PPARγ2-aP2 pathway. other hsa-mir-378 Obesity 24923530 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Insight into the effects of adipose tissue inflammation factors on miR-378 expression and the underlying mechanism. other hsa-mir-378 Obesity 27721392 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs. other hsa-mir-425 Obesity 25701361 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. other hsa-mir-483 Obesity 26148871 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. other hsa-mir-634 Obesity 25701361 disease of metabolism DOID:9970 E66 D009765 601665 HP:0001513 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. other hsa-mir-129 Oral Leukoplakia 25576219 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression. other hsa-mir-205 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-21 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-31 Oral Leukoplakia 25576219 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression. other hsa-mir-31 Oral Leukoplakia 22719913 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia. other hsa-mir-323 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-339 Oral Leukoplakia 25576219 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression. other hsa-mir-423 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-491 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-499 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-525 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-549 Oral Leukoplakia 26064958 gastrointestinal system disease DOID:9655 K13.21 D007972 HP:0002745 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. other hsa-mir-146a Oral Lichen Planus 27063128 L43.9 D017676 HP:0031453 Detection of miR-155, miR-146a in PBNCs and tissues from patients with oral lichen planus. other hsa-mir-146b Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-155 Oral Lichen Planus 27063128 L43.9 D017676 HP:0031453 Detection of miR-155, miR-146a in PBNCs and tissues from patients with oral lichen planus. other hsa-mir-190 Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-26b Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-29a Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-595 Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-628 Oral Lichen Planus 26064947 L43.9 D017676 HP:0031453 The TF-miRNA Coregulation Network in Oral Lichen Planus. other hsa-mir-34a Oral Neoplasms 25973020 C06.9 D009062 HP:0100649 MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor. other hsa-mir-375 Oral Neoplasms 28713923 C06.9 D009062 HP:0100649 The differential regulation of microRNAs is associated with oral cancer other hsa-mir-4505 Oral Neoplasms 27207653 C06.9 D009062 HP:0100649 a microRNA (miR) analysis revealed that LCN2 can suppress CAIX expression and cell migration through miR-4505 induction. other hsa-mir-494 Oral Neoplasms 25500095 C06.9 D009062 HP:0100649 the role of miR-494 as a tumor suppressor miRNA in oral cancer. other hsa-mir-122 Osteoarthritis 26239639 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1α 3'-untranslated region is associated with a risk for osteoarthritis. other hsa-mir-130a Osteoarthritis 29532889 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway other hsa-mir-140 Osteoarthritis 20516192 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 miR-140:miR-140 has a critical and nonredundant role in cartilage development and homeostasis other hsa-mir-140 Osteoarthritis 23281373 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Detection of the expression level of miR-140 using realtime fluorescent quantitative PCR in knee synovial fluid of osteoarthritis patients other hsa-mir-140 Osteoarthritis 23942573 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. other hsa-mir-140 Osteoarthritis 19948051 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes. other hsa-mir-140 Osteoarthritis 20466812 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 We show that miR-140 regulates cartilage development and homeostasis, and its loss contributes to the development of age-related OA-like changes. other hsa-mir-140 Osteoarthritis 22273691 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Expression of miRNA-140 and MMP-13 was elevated in IL-1β-stimulated C28/I2 cells. other hsa-mir-140 Osteoarthritis 23291479 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development. other hsa-mir-140 Osteoarthritis 27165343 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 estrogen acts via ER and miR-140 to inhibit the catabolic activity of proteases within the chondrocyte extracellular matrix. other hsa-mir-140 Osteoarthritis 29095952 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. other hsa-mir-146a Osteoarthritis 24939082 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro. other hsa-mir-146a Osteoarthritis 18438844 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 This study shows that miR-146 is expressed in RA synovial tissue and that its expression is induced by stimulation with TNFalpha and IL-1beta. Further studies are required to elucidate the function of miR-146 in these tissues. other hsa-mir-146a Osteoarthritis 25052989 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 The mechanism underlying the inhibitory effects of denbinobin involved miR-146a induction, which in turn inhibited NF-魏B signaling. other hsa-mir-146a Osteoarthritis 29292727 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 the modification of miR-146a and miR-34a in OA chondrocytes subjected to H2O2 stimulus and we confirmed the antioxidant effect of taurine other hsa-mir-146a Osteoarthritis 29449647 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 they express a remarkably high basal level of miR-147a, a microRNA known to negatively regulate the TLR pathway other hsa-mir-146a Osteoarthritis 29575548 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 miR-146a may be used to counter both aging-associated OA and mechanical injury-/inflammation-induced PTOA other hsa-mir-148a Osteoarthritis 24269634 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Overexpression of hsa-miR-148a inhibits hypertrophic differentiation and increases the production and deposition of type II collagen by OA chondrocytes, which is accompanied by an increased retention of proteoglycans.Hsa-miR-148a might be a potential disease-modifying compound in OA, as it promotes hyaline cartilage production. other hsa-mir-188 Osteoarthritis 24928913 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 In IL-1尾-stimulated human chondrocytes, chosen as a model of differentiated phenotype loss implicating the PPi transporter ANK, miR-9, miR-188 and let7e levels increased. other hsa-mir-27a Osteoarthritis 19948051 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes. other hsa-mir-27b Osteoarthritis 20131257 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 miR-27b:MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes other hsa-mir-335 Osteoarthritis 26243143 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis. other hsa-mir-34a Osteoarthritis 29292727 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 the modification of miR-146a and miR-34a in OA chondrocytes subjected to H2O2 stimulus and we confirmed the antioxidant effect of taurine other hsa-mir-483 Osteoarthritis 28139355 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. other hsa-mir-519b Osteoarthritis 28423042 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis. other hsa-mir-9 Osteoarthritis 27404795 musculoskeletal system disease DOID:8398 M19.9 D010003 165720 HP:0002758 IL-6 expression is achieved through increased recruitment of CEBP伪 to the MCPIP1 promoter and by relieving the miR-9-mediated inhibition of MCPIP1 expression in OA chondrocytes. other hsa-mir-145 Osteogenesis Imperfecta 27551756 musculoskeletal system disease DOID:12347 Q78.0 D010013 PS166200 Ossotide promotes cell differentiation of human osteoblasts from osteogenesis imperfecta patients by up-regulating miR-145. other hsa-let-7g Osteoporosis 27665867 musculoskeletal system disease DOID:11476 M80 D010024 166710 HP:0000939 An insertion/deletion polymorphism within the 3'‑untranslated region of COL1A2 confers susceptibility to osteoporosis. other hsa-mir-210 Osteoporosis 25503465 musculoskeletal system disease DOID:11476 M80 D010024 166710 HP:0000939 miR-210 played an important role in ameliorating the estrogen deficiency caused-postmenopausal osteoporosis through promotion the VEGF expression and osteoblast differentiation. other hsa-mir-34 Osteoporosis 24815299 musculoskeletal system disease DOID:11476 M80 D010024 166710 HP:0000939 miR-34 has also been implicated in various non-cancerous diseases, such as brain disorders, osteoporosis, and cardiovascular complications. other hsa-mir-422a Osteoporosis 24820117 musculoskeletal system disease DOID:11476 M80 D010024 166710 HP:0000939 MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis. other hsa-mir-637 Osteoporosis 21880893 musculoskeletal system disease DOID:11476 M80 D010024 166710 HP:0000939 miR-637 suppressed the growth of hMSCs and induced S-phase arrest. Expression of miR-637 was increased during adipocyte differentiation (AD) whereas it was decreased during osteoblast differentiation (OS), which suggests that miR-637 could act as a mediator of adipo-osteogenic differentiation. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. Therefore, miR-637 could contributes to osteoporosis. other hsa-mir-145 Osteoporosis, Postmenopausal 28260003 M81.0 D015663 Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells. other hsa-let-7 Osteosarcoma 24457375 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 the involvement of let-7 family miRNA in regulation of the cell proliferation as well as epithelial-mesenchymal transition of OS. other hsa-let-7d Osteosarcoma 26679758 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. other hsa-mir-101 Osteosarcoma 25013866 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-101 blocks autophagy during the chemotherapy in osteosarcoma cells and enhances chemosensitivity in vitro. other hsa-mir-1-1 Osteosarcoma 23229283 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control other hsa-mir-1-2 Osteosarcoma 23229283 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control other hsa-mir-122 Osteosarcoma 25269820 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. other hsa-mir-124 Osteosarcoma 24971902 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 The tumor suppressor role of miR-124 in osteosarcoma. other hsa-mir-125b Osteosarcoma 27990096 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. other hsa-mir-130b Osteosarcoma 26446495 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Taken together, our data indicated that high miR-130b level and low level of miR-218 are associated with poor clinicopathological characteristics.Furthermore, miR-130b may play a key role in the progression of osteosarcoma. other hsa-mir-133b Osteosarcoma 23229283 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control other hsa-mir-140 Osteosarcoma 19734943 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts other hsa-mir-141 Osteosarcoma 24307282 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Tumor-suppressing effects of miR-141 in human osteosarcoma. other hsa-mir-143 Osteosarcoma 21427707 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression. other hsa-mir-143 Osteosarcoma 24525123 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. other hsa-mir-143 Osteosarcoma 24762226 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Propofol inhibits proliferation and invasion of osteosarcoma cells by regulation of microRNA-143 expression. other hsa-mir-143 Osteosarcoma 25227664 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MiR-143 inhibits EGFR-signaling-dependent osteosarcoma invasion. other hsa-mir-143 Osteosarcoma 23430952 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. other hsa-mir-144 Osteosarcoma 25854173 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-144 inhibits the proliferation, apoptosis, invasion, and migration of osteosarcoma cell line F5M2. other hsa-mir-145 Osteosarcoma 23430952 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. other hsa-mir-148a Osteosarcoma 26111756 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a. other hsa-mir-155 Osteosarcoma 25666090 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism. other hsa-mir-16 Osteosarcoma 27460987 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Moreover, GLIPR1 overexpression upregulated miR-16 in osteosarcoma cells. other hsa-mir-181a-1 Osteosarcoma 23740615 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell. other hsa-mir-181a-2 Osteosarcoma 23740615 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell. other hsa-mir-181c Osteosarcoma 26062442 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-181c associates with tumor relapse of high grade osteosarcoma. other hsa-mir-199a Osteosarcoma 24957404 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells. other hsa-mir-199a Osteosarcoma 25931818 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells. other hsa-mir-19b-1 Osteosarcoma 23574781 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma other hsa-mir-19b-2 Osteosarcoma 23574781 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma other hsa-mir-200 Osteosarcoma 24815002 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Busulfan inhibits growth of human osteosarcoma through miR-200 family microRNAs in vitro and in vivo. other hsa-mir-200b Osteosarcoma 23430952 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. other hsa-mir-200c Osteosarcoma 23430952 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. other hsa-mir-210 Osteosarcoma 28032372 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-210 is increased and it is required for dedifferentiation of osteosarcoma cell line. other hsa-mir-212 Osteosarcoma 25562164 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 The miR-212/Sox4 interaction plays an important role of in the osteosarcoma progression. other hsa-mir-214 Osteosarcoma 27840941 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Deregulated WWOX is involved in a negative feedback loop with microRNA-214-3p in osteosarcoma. other hsa-mir-217 Osteosarcoma 26062553 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis. other hsa-mir-218 Osteosarcoma 26446495 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Taken together, our data indicated that high miR-130b level and low level of miR-218 are associated with poor clinicopathological characteristics.Furthermore, miR-130b may play a key role in the progression of osteosarcoma. other hsa-mir-221 Osteosarcoma 23372675 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma other hsa-mir-221 Osteosarcoma 26397386 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Taken together, our results suggest that miR-221 enhances the proliferation,invasion and migration ability of osteosarcoma cells partly by suppressing PTEN. other hsa-mir-221 Osteosarcoma 28074104 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221. other hsa-mir-223 Osteosarcoma 24784921 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Prognostic value of microRNA-223/epithelial cell transforming sequence 2 signaling in patients with osteosarcoma. other hsa-mir-23a Osteosarcoma 26160225 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma. other hsa-mir-24 Osteosarcoma 25142229 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. other hsa-mir-27a Osteosarcoma 25749032 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells. other hsa-mir-27a Osteosarcoma 27429847 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway. other hsa-mir-29a Osteosarcoma 25142229 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. other hsa-mir-29a Osteosarcoma 25015394 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. other hsa-mir-29b Osteosarcoma 25015394 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. other hsa-mir-29b Osteosarcoma 25337211 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 A key role of microRNA-29b in suppression of osteosarcoma cell proliferation and migration via modulation of VEGF. other hsa-mir-29b-1 Osteosarcoma 25174983 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-29b-1 impairs in vitro cell proliferation, self-renewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells. other hsa-mir-29c Osteosarcoma 25015394 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. other hsa-mir-302b Osteosarcoma 23845851 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Epirubicin-mediated expression of miR-302b is involved in osteosarcoma apoptosis and cell cycle regulation. other hsa-mir-34a Osteosarcoma 22457788 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo. other hsa-mir-34a Osteosarcoma 24957404 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells. other hsa-mir-34a Osteosarcoma 25490093 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 cell response to etoposide-induced DNA damage was not compromised in cells with dominant-negative p53 expression. other hsa-mir-34a Osteosarcoma 23430952 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. other hsa-mir-34a Osteosarcoma 28635396 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2. other hsa-mir-34c Osteosarcoma 23720736 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. other hsa-mir-34c Osteosarcoma 24802328 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 MiR-34c inhibits osteosarcoma metastasis and chemoresistance. other hsa-mir-375 Osteosarcoma 26381132 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Formononetin has inhibitory effects on the proliferation of U2SO cells, both in vitro and in vivo. This antitumor effect is directly correlated with formononetin concentration. other hsa-mir-382 Osteosarcoma 25344865 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma. other hsa-mir-410 Osteosarcoma 25385479 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 VEGF-mediated suppression of cell proliferation and invasion by miR-410 in osteosarcoma. other hsa-mir-451 Osteosarcoma 25391425 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-451 may play an important role in tumor growth and metastasis in osteosarcoma. other hsa-mir-451 Osteosarcoma 25869073 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Suppression of liver receptor homolog-1 by microRNA-451 represses the proliferation of osteosarcoma cells. other hsa-mir-486 Osteosarcoma 28339053 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway. other hsa-mir-497 Osteosarcoma 26202364 disease of cellular proliferation DOID:3347 D012516 259500 HP:0002669 Taken together, our results suggest that miR-497 modulates the sensitivity to cisplatin at least in part through PI3K/Akt pathway in osteosarcoma cells. other hsa-mir-10a Ovarian Disease 26979400 endocrine system disease DOID:1100 E28.9 D010049 AFSC-derived exosomes prevent ovarian follicular atresia in CTx-treated mice via the delivery of microRNAs in which both miR-146a and miR-10a are highly enriched and their potential target genes are critical to apoptosis. other hsa-let-7 Ovarian Neoplasms 24393345 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. other hsa-let-7 Ovarian Neoplasms 29658612 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer other hsa-let-7 Ovarian Neoplasms 21618519 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. other hsa-let-7a Ovarian Neoplasms 24643702 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 E(2) + P4 significantly inhibited the cell survival, promoted the cell apoptosis, induced the expression of let-7a and miR-34b, and reduced the expression of Bcl-2 in ovarian cancer cells. other hsa-let-7a Ovarian Neoplasms 19477633 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Our study also suggests that lin-28B may promote ovarian cancer progression and serve as an unfavourable prognostic marker for the disease. other hsa-let-7a Ovarian Neoplasms 21122376 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis. other hsa-let-7e Ovarian Neoplasms 21122376 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis. other hsa-let-7f Ovarian Neoplasms 21122376 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis. other hsa-let-7i Ovarian Neoplasms 22812695 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Our study indicated that this MUC1/let-7i chimera can specifically reverse chemoresistance to paclitaxel. other hsa-mir-1 Ovarian Neoplasms 27354590 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 loss of growth-inhibitory functionality of miR-1 other hsa-mir-100 Ovarian Neoplasms 18451233 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 normal other hsa-mir-101-1 Ovarian Neoplasms 21818714 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21(waf1/cip1). other hsa-mir-101-2 Ovarian Neoplasms 21818714 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21(waf1/cip1). other hsa-mir-1181 Ovarian Neoplasms 26151663 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer. other hsa-mir-124 Ovarian Neoplasms 26655797 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. other hsa-mir-125a Ovarian Neoplasms 18451233 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 normal other hsa-mir-129 Ovarian Neoplasms 25895125 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. other hsa-mir-1307 Ovarian Neoplasms 25887170 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer. other hsa-mir-130a Ovarian Neoplasms 20083225 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools. other hsa-mir-130b Ovarian Neoplasms 25155039 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA 130b enhances drug resistance in human ovarian cancer cells. other hsa-mir-141 Ovarian Neoplasms 26725650 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR-200c/141 exert key functions. other hsa-mir-141 Ovarian Neoplasms 22101765 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. other hsa-mir-141 Ovarian Neoplasms 22897840 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Some genes involved in EMT, such as BMP and activin membrane-bound inhibitor (BAMBI), and mir-141 resulted in association with overall or progression free survival. other hsa-mir-141 Ovarian Neoplasms 21051560 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final β-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. other hsa-mir-145 Ovarian Neoplasms 18451233 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 normal other hsa-mir-146a Ovarian Neoplasms 25537514 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. other hsa-mir-146a Ovarian Neoplasms 20810544 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. other hsa-mir-146a Ovarian Neoplasms 21591024 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, the polymorphism in the miR-146a gene is unlikely to be of substantial significance regarding breast cancer risk. other hsa-mir-146b Ovarian Neoplasms 21266476 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Induction of miR-146b by PDGF-BB is modulated via MAPK-dependent induction of c-fos. other hsa-mir-148a Ovarian Neoplasms 25537514 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. other hsa-mir-148a Ovarian Neoplasms 21971665 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Ovarian Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. other hsa-mir-148a Ovarian Neoplasms 29069830 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 The selected signature composed by VAT1L, CALR, LINC01456, RP11-484L8.1, MIR196A1 and MIR148A, separated the training group patients into high-risk or low-risk subgroup with significantly different survival time other hsa-mir-152 Ovarian Neoplasms 21971665 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Ovarian Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. other hsa-mir-155 Ovarian Neoplasms 26655797 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. other hsa-mir-181a Ovarian Neoplasms 27249598 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-181a overexpression decreased the PTX sensitivity of SKOV3 cells and while miR-181a inhibition increased the sensitivity of SKOV3/PTX cells. other hsa-mir-181b Ovarian Neoplasms 26655797 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. other hsa-mir-196a-1 Ovarian Neoplasms 29069830 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 The selected signature composed by VAT1L, CALR, LINC01456, RP11-484L8.1, MIR196A1 and MIR148A, separated the training group patients into high-risk or low-risk subgroup with significantly different survival time other hsa-mir-199 Ovarian Neoplasms 26819477 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-199a-5p and miR-34a-5p showed specific association with the disease, including molecular and cellular functions other hsa-mir-199a-1 Ovarian Neoplasms 20400975 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-199a:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214 other hsa-mir-199a-2 Ovarian Neoplasms 20400975 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-199a:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214 other hsa-mir-19a Ovarian Neoplasms 24929208 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-19a was also transported via TnTs connecting transfected K7M2 cells and nontransfected stromal MC3T3 murine osteoblast cells. other hsa-mir-200 Ovarian Neoplasms 24393345 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. other hsa-mir-200 Ovarian Neoplasms 24447705 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Sequence variation among members of the miR-200 microRNA family is correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells. other hsa-mir-200 Ovarian Neoplasms 24966949 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Clinicopathological and prognostic implications of the miR-200 family in patients with epithelial ovarian cancer. other hsa-mir-200 Ovarian Neoplasms 26910180 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 The prognostic value of the miR-200 family in ovarian cancer: a meta-analysis. other hsa-mir-200a Ovarian Neoplasms 25327865 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Involvement of miR-200a in chemosensitivity regulation of ovarian cancer. other hsa-mir-200a Ovarian Neoplasms 23888941 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. other hsa-mir-200a Ovarian Neoplasms 20035894 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-200a:involved in epithelial-to-mesenchymal transition (EMT) other hsa-mir-200a Ovarian Neoplasms 22101765 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. other hsa-mir-200a Ovarian Neoplasms 21051560 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final β-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. other hsa-mir-200b Ovarian Neoplasms 20035894 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-200b:involved in epithelial-to-mesenchymal transition (EMT) other hsa-mir-200b Ovarian Neoplasms 28399108 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition. other hsa-mir-200b Ovarian Neoplasms 21051560 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final β-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. other hsa-mir-200c Ovarian Neoplasms 26725650 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR-200c/141 exert key functions. other hsa-mir-200c Ovarian Neoplasms 20035894 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-200c:involved in epithelial-to-mesenchymal transition (EMT) other hsa-mir-200c Ovarian Neoplasms 23074172 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel other hsa-mir-200c Ovarian Neoplasms 23394580 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer other hsa-mir-200c Ovarian Neoplasms 27601996 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. other hsa-mir-200c Ovarian Neoplasms 28399108 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition. other hsa-mir-200c Ovarian Neoplasms 21051560 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final β-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. other hsa-mir-20a Ovarian Neoplasms 28789409 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA-20a contributes to cisplatin-resistance and migration of OVCAR3 ovarian cancer cell line. other hsa-mir-21 Ovarian Neoplasms 24865582 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. other hsa-mir-21 Ovarian Neoplasms 18451233 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 normal other hsa-mir-210 Ovarian Neoplasms 26640557 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-923, miR-1246, miR-149*, miR-638 and miR-210 were upregulated and miR-99a, miR-181a-2* and miR-339-5p were downregulated following bafilomycin A1 treatment. other hsa-mir-214 Ovarian Neoplasms 20400975 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-214:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214 other hsa-mir-214 Ovarian Neoplasms 18199536 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway. other hsa-mir-214 Ovarian Neoplasms 20083225 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools. other hsa-mir-22 Ovarian Neoplasms 20869762 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-22:miR-22 might be involved in inhibiting ovarian cancer metastasis other hsa-mir-22 Ovarian Neoplasms 21122376 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis. other hsa-mir-24 Ovarian Neoplasms 26296081 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Enrichment Analysis Identifies Functional MicroRNA-Disease Associations in Humans. other hsa-mir-26a Ovarian Neoplasms 24466274 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MiR-26a promotes ovarian cancer proliferation and tumorigenesis. other hsa-mir-27a Ovarian Neoplasms 23254909 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells other hsa-mir-27a Ovarian Neoplasms 20083225 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools. other hsa-mir-27b Ovarian Neoplasms 28396577 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA-27b functions as a new inhibitor of ovarian cancer-mediated vasculogenic mimicry through suppression of VE-cadherin expression. other hsa-mir-29 Ovarian Neoplasms 23904094 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. other hsa-mir-302a Ovarian Neoplasms 26191180 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MiR-302a inhibits the tumorigenicity of ovarian cancer cells by suppression of SDC1. other hsa-mir-30d Ovarian Neoplasms 22058146 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A combined array-based comparative genomic hybridization (aCGH) and functional library screening approach identifies mir-30d as an oncomir in cancer. other hsa-mir-31 Ovarian Neoplasms 23552883 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET other hsa-mir-34a Ovarian Neoplasms 26819477 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-199a-5p and miR-34a-5p showed specific association with the disease, including molecular and cellular functions other hsa-mir-34a Ovarian Neoplasms 21423204 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 We propose that elevated TRP53 and miR-34a-c may exert negatively regulatory effects that reduce the proliferative potential of OSE cells leading to the low-grade serous adenocarcinoma phenotype. other hsa-mir-34a Ovarian Neoplasms 21516127 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MiRIDIAN-based knockdown and induction of miR-34a evidenced a direct regulatory link between miR-34a and E2F3a, and the tumor-suppressive character of miR-34a was documented by its association with improved survival. other hsa-mir-34b Ovarian Neoplasms 24643702 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 E(2) + P4 significantly inhibited the cell survival, promoted the cell apoptosis, induced the expression of let-7a and miR-34b, and reduced the expression of Bcl-2 in ovarian cancer cells. other hsa-mir-34c Ovarian Neoplasms 25273528 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. other hsa-mir-367 Ovarian Neoplasms 24220856 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Overexpression of miR-367 in the paclitaxel-sensitive cells [PA1; IC₅₀, 1.69 nM, high miR-367 (2.997), low miR-30a-5p (-0.323)] further increased paclitaxel sensitivity, whereas miR-367 depletion decreased paclitaxel sensitivity. other hsa-mir-370 Ovarian Neoplasms 29403287 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Long noncoding RNA H19 promotes transforming growth factor-β-induced epithelial-mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells other hsa-mir-375 Ovarian Neoplasms 23696927 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Mir-375 enhances ruthenium-derived compound Rawq01 induced cell death in human ovarian cancer. other hsa-mir-376 Ovarian Neoplasms 26940843 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MIR376 as an important microRNA family for cancer formation and progression other hsa-mir-429 Ovarian Neoplasms 21277012 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. other hsa-mir-429 Ovarian Neoplasms 21051560 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final β-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients. other hsa-mir-451 Ovarian Neoplasms 20083225 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools. other hsa-mir-490 Ovarian Neoplasms 25297343 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells. other hsa-mir-517a Ovarian Neoplasms 26655797 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. other hsa-mir-545 Ovarian Neoplasms 25537514 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. other hsa-mir-630 Ovarian Neoplasms 29452092 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MicroRNA-630 inhibitor sensitizes chemoresistant ovarian cancer to chemotherapy by enhancing apoptosis. other hsa-mir-7 Ovarian Neoplasms 29411964 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Enhanced Chemotherapeutic Efficacy of Paclitaxel Nanoparticles Co-delivered with MicroRNA-7 by Inhibiting Paclitaxel-Induced EGFR/ERK pathway Activation for Ovarian Cancer Therapy other hsa-mir-718 Ovarian Neoplasms 24815691 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 MiR-718 represses VEGF and inhibits ovarian cancer cell progression. other hsa-mir-886 Ovarian Neoplasms 21122376 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis. other hsa-mir-92a-1 Ovarian Neoplasms 23499550 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin Expression. other hsa-mir-92a-2 Ovarian Neoplasms 23499550 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin α5 Expression. other hsa-mir-92b Ovarian Neoplasms 28693226 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Screening of potentially crucial genes and regulatory factors involved in epithelial ovarian cancer using microarray analysis. other hsa-mir-940 Ovarian Neoplasms 28423620 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs. other hsa-mir-99a Ovarian Neoplasms 18451233 endocrine system disease DOID:2394 C56 D010051 167000 HP:0100615 normal other hsa-mir-106b Ovary Mixed Epithelial Carcinoma 25933027 endocrine system disease DOID:6898 Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. other hsa-mir-135a Pain 26498117 R52 D010146 These results show that circulating miRNA predict persistent severe axial pain after MVC and suggest that they may be involved in the pathogenesis of post-traumatic musculoskeletal pain. However, further studies are needed to determine if these miRNA play a direct causal role. other hsa-mir-182 Pain 19699278 R52 D010146 association with chronic neuropathic pain, mechanical hypersensitivity other hsa-mir-183 Pain 19699278 R52 D010146 association with chronic neuropathic pain, mechanical hypersensitivity other hsa-mir-34a Pain 19699278 R52 D010146 association with chronic neuropathic pain, mechanical hypersensitivity other hsa-mir-34a Pain 27917453 R52 D010146 Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors. other hsa-mir-3613 Pain 26498117 R52 D010146 These results show that circulating miRNA predict persistent severe axial pain after MVC and suggest that they may be involved in the pathogenesis of post-traumatic musculoskeletal pain. However, further studies are needed to determine if these miRNA play a direct causal role. other hsa-mir-96 Pain 19699278 R52 D010146 association with chronic neuropathic pain, mechanical hypersensitivity other hsa-mir-145 Pancreatic Adenocarcinoma 27765914 disease of cellular proliferation DOID:4074 C25.3 MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. other hsa-mir-155 Pancreatic Adenocarcinoma 20332664 disease of cellular proliferation DOID:4074 C25.3 Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma other hsa-mir-155 Pancreatic Adenocarcinoma 27456015 disease of cellular proliferation DOID:4074 C25.3 whereas miRNA-30c, miRNA-21, and miRNA-155 levels and CK19 mRNA levels in station 8 nodes were variable and did not correlate with RFS or OS. other hsa-mir-206 Pancreatic Adenocarcinoma 25500542 disease of cellular proliferation DOID:4074 C25.3 miR-206 as a pleiotropic modulator of different hallmarks of cancer, and as such raising the intriguing possibility that miR-206 may be an attractive candidate for miRNA-based anticancer therapies. other hsa-mir-21 Pancreatic Adenocarcinoma 19730150 disease of cellular proliferation DOID:4074 C25.3 Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma. other hsa-mir-221 Pancreatic Adenocarcinoma 19730150 disease of cellular proliferation DOID:4074 C25.3 Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma. other hsa-mir-23b Pancreatic Adenocarcinoma 24070722 disease of cellular proliferation DOID:4074 C25.3 Mir-23B might be used as a biomarker for PDAC resistance to radiotherapy or chemotherapy. Or, patients with low tumor levels of Mir-23B might benefit from pharmacologic inhibitors of autophagy. other hsa-let-7a Pancreatic Neoplasms 24040120 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. other hsa-let-7a Pancreatic Neoplasms 23335963 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 These data demonstrate an intricate post-transcriptional regulation of RRM2 and chemosensitivity by let-7a and that the manipulation of regulatory proteins involved in let-7a transcription/processing may provide a mechanism for improving chemotherapeutic and/or tumor growth control responses in pancreatic cancer. other hsa-let-7a-1 Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7a-1 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-let-7a-2 Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7a-2 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-let-7a-3 Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7a-3 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-let-7b Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7b: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7b Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-let-7c Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-let-7c Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7c: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7c Pancreatic Neoplasms 22245693 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. other hsa-let-7d Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7d: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7e Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7e: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7f-1 Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7f: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7f-2 Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7f: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7g Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7g: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-let-7i Pancreatic Neoplasms 19323605 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Let-7i: inhibits in vitro cell proliferation but fails to alter tumor progression other hsa-mir-100 Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-101 Pancreatic Neoplasms 26828016 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer. other hsa-mir-101-1 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-101-1 Pancreatic Neoplasms 22943841 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. other hsa-mir-101-1 Pancreatic Neoplasms 23139258 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms other hsa-mir-101-2 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-101-2 Pancreatic Neoplasms 22943841 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. other hsa-mir-101-2 Pancreatic Neoplasms 23139258 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms other hsa-mir-103 Pancreatic Neoplasms 23674172 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our study demonstrates that the pathophysiology of HNF1A-MODY is associated with the overexpression of miR-103 and miR-224. other hsa-mir-103a-1 Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-103a-2 Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-103b-1 Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-103b-2 Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-106a Pancreatic Neoplasms 24444603 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Upregulated miR-106a plays an oncogenic role in pancreatic cancer. other hsa-mir-10a Pancreatic Neoplasms 19747919 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Inhibition of miR-10a expression (with retinoic acid receptor antagonists) or function (with specific inhibitors) is a promising starting point for antimetastatic therapies. other hsa-mir-10b Pancreatic Neoplasms 26444644 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our findings suggest that this unique technique can be used to design novel diagnostic strategies for pancreatic and other cancers based on the direct quantitative measurement of plasma and exosome microRNAs, and can be readily extended to other diseases with identifiable microRNA signatures. other hsa-mir-10b Pancreatic Neoplasms 21652542 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 microRNA-10b Expression Correlates with Response to Neoadjuvant Therapy and Survival in Pancreatic Ductal Adenocarcinoma. other hsa-mir-1181 Pancreatic Neoplasms 25444909 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-1181 plays a vital role in inhibiting the CSCs-like phenotypes in pancreatic cancer and might represent a potential target for anti-pancreatic cancer. other hsa-mir-126 Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-130a Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-132 Pancreatic Neoplasms 25840985 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Xenograft tumors treated with ormeloxifene in combination with gemcitabine restored the tumor-suppressor miR-132 and inhibited stromal cell infiltration into the tumor tissues. other hsa-mir-135b Pancreatic Neoplasms 21953293 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Using relative qRT-PCR to measure miR-135b normalized to miR-24 in 75 FFPE specimens (42 PDAC and 33 CP) covering a broad range of tumor content, the authors discriminated CP from PDAC with a sensitivity and specificity of 92.9% [95%CI=(80.5,98.5)] and 93.4% [95%CI=(79.8,99.3)], respectively. Therefore, miR-135b could be a novel biomarker for pancreatic ductal adenocarcinoma. other hsa-mir-143 Pancreatic Neoplasms 21159815 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. other hsa-mir-143 Pancreatic Neoplasms 23070684 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway other hsa-mir-143 Pancreatic Neoplasms 21159816 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Additionally, KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling. other hsa-mir-145 Pancreatic Neoplasms 24040120 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. other hsa-mir-145 Pancreatic Neoplasms 21159815 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. other hsa-mir-145 Pancreatic Neoplasms 29464032 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Selective packaging of miRNAs into EVs led to enrichment of stromal specific miR-145 in EVs secreted by TAS cells other hsa-mir-145 Pancreatic Neoplasms 21159816 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Additionally, KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling. other hsa-mir-145 Pancreatic Neoplasms 23834149 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 insulingrowth factor-1 receptor expression (miR-7, miR-139, miR-145, miR-1); other hsa-mir-146a Pancreatic Neoplasms 22311263 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation. other hsa-mir-146a Pancreatic Neoplasms 20124483 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-146a suppresses invasion of pancreatic cancer cells. other hsa-mir-148a Pancreatic Neoplasms 25950085 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy. other hsa-mir-148a Pancreatic Neoplasms 24895996 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. other hsa-mir-155 Pancreatic Neoplasms 23776656 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 It is possible that mirNA participates in the pathophysiology of pancreatic cancer, but the current popular methods do not accurately reveal the real-time mirNA function. Thus, this report provided a convenient, accurate, and sensitive approach to mirNA research. other hsa-mir-155 Pancreatic Neoplasms 23817566 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. other hsa-mir-155 Pancreatic Neoplasms 26195069 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts. other hsa-mir-155 Pancreatic Neoplasms 21826251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 preferential expression in holoclones other hsa-mir-155 Pancreatic Neoplasms 23139258 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms other hsa-mir-155 Pancreatic Neoplasms 27060060 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis other hsa-mir-15b Pancreatic Neoplasms 26166038 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer. other hsa-mir-15b Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-15b Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-16 Pancreatic Neoplasms 24600978 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The combination of miR-16 and CA19-9 detections boosted the diagnostic performance in pancreatic cancer detection. other hsa-mir-16-1 Pancreatic Neoplasms 21913185 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. other hsa-mir-16-2 Pancreatic Neoplasms 21913185 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. other hsa-mir-17 Pancreatic Neoplasms 27400681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Mechanically, we discovered that high GFR伪2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level. other hsa-mir-181b Pancreatic Neoplasms 25126577 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Some miRNAs were found to be specifically expressed in some ZHENGs, for instance, miR-17, miR-21, and miR-181b in Shi-Re ZHENG and miR-196a in Pi-Xu ZHENG. other hsa-mir-181b Pancreatic Neoplasms 22504911 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-181b and miR-210 discriminatedPCa from normal individuals with receiver operating characteristic (ROC) curves and area under curve (AUC-ROC) of 0.745 and 0.772, respectively. other hsa-mir-186 Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-18a Pancreatic Neoplasms 28822990 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 αM and γM can induce apoptosis and autophagy in pancreatic cancer cells and that their anti-cancer effect is likely to be associated with miR-18a other hsa-mir-190 Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-192 Pancreatic Neoplasms 22245693 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. other hsa-mir-196a-1 Pancreatic Neoplasms 21913185 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. other hsa-mir-196a-2 Pancreatic Neoplasms 21913185 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. other hsa-mir-196b Pancreatic Neoplasms 28186267 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer. other hsa-mir-200 Pancreatic Neoplasms 24040120 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. other hsa-mir-200a Pancreatic Neoplasms 24521357 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell. other hsa-mir-200a Pancreatic Neoplasms 20388782 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-200:Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF other hsa-mir-200a Pancreatic Neoplasms 21285251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. other hsa-mir-200a Pancreatic Neoplasms 21408027 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer. other hsa-mir-200b Pancreatic Neoplasms 23776656 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 It is possible that mirNA participates in the pathophysiology of pancreatic cancer, but the current popular methods do not accurately reveal the real-time mirNA function. Thus, this report provided a convenient, accurate, and sensitive approach to mirNA research. other hsa-mir-200b Pancreatic Neoplasms 21408027 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. other hsa-mir-200b Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-200b Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-200c Pancreatic Neoplasms 21408027 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. other hsa-mir-200c Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-200c Pancreatic Neoplasms 19112422 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Expression of microRNA was determined with microRNA array. Expression of miR-200c and miR-21 was detected by Northern blotting. other hsa-mir-203 Pancreatic Neoplasms 25872941 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This led to the identification of both its target gene miR-203 as a major drug sensitizer other hsa-mir-203 Pancreatic Neoplasms 28382422 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The Role of Exosomes in Pancreatic Cancer Microenvironment. other hsa-mir-204 Pancreatic Neoplasms 24025188 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Triptolide mediated miR-204 increase causes pancreatic cancer cell death via loss of Mcl-1. other hsa-mir-208 Pancreatic Neoplasms 24604208 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion. other hsa-mir-21 Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-21 Pancreatic Neoplasms 20388782 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-21:Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF other hsa-mir-21 Pancreatic Neoplasms 20498843 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 microRNA-21:Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer other hsa-mir-21 Pancreatic Neoplasms 21408027 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer. other hsa-mir-21 Pancreatic Neoplasms 21826251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 preferential expression in holoclones other hsa-mir-21 Pancreatic Neoplasms 23139258 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms other hsa-mir-21 Pancreatic Neoplasms 23752880 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. other hsa-mir-21 Pancreatic Neoplasms 27060060 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis other hsa-mir-21 Pancreatic Neoplasms 28304379 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing. other hsa-mir-21 Pancreatic Neoplasms 28382422 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The Role of Exosomes in Pancreatic Cancer Microenvironment. other hsa-mir-21 Pancreatic Neoplasms 28438662 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer. other hsa-mir-210 Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-210 Pancreatic Neoplasms 24395300 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response. other hsa-mir-210 Pancreatic Neoplasms 22672828 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-210 expression in PC cells is induced by hypoxia through a HIF-1alpha-dependent pathway, but does not influence PC cell proliferation. other hsa-mir-210 Pancreatic Neoplasms 19782034 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 When human head and neck or pancreatic tumor cells ectopically expressing mir-210 were implanted into immunodeficient mice, mir-210 repressed initiation of tumor growth. other hsa-mir-211 Pancreatic Neoplasms 23155457 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer other hsa-mir-214 Pancreatic Neoplasms 21826251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 preferential expression in holoclones other hsa-mir-216 Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-216a Pancreatic Neoplasms 26134156 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy. other hsa-mir-216a Pancreatic Neoplasms 24895996 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. other hsa-mir-221 Pancreatic Neoplasms 25955843 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. other hsa-mir-221 Pancreatic Neoplasms 21779484 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The miRNA is Potentially Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer other hsa-mir-221 Pancreatic Neoplasms 21826251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 preferential expression in holoclones other hsa-mir-221 Pancreatic Neoplasms 23752880 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. other hsa-mir-221 Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-222 Pancreatic Neoplasms 24026657 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This study provides the first evidence of a potential link between Ki67 and micro-RNA-222, which are both relevant to cell proliferation. Our data suggest the potential of micro-RNA-222 as a prognostic biomarker for the pancreatic cancer. other hsa-mir-222 Pancreatic Neoplasms 21826251 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 preferential expression in holoclones other hsa-mir-222 Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-224 Pancreatic Neoplasms 19475450 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-224 and miR-486 are associated with the progression of pancreatic ductal adenocarcinomas other hsa-mir-224 Pancreatic Neoplasms 23674172 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our study demonstrates that the pathophysiology of HNF1A-MODY is associated with the overexpression of miR-103 and miR-224. other hsa-mir-23a Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-23a Pancreatic Neoplasms 22479426 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers. other hsa-mir-23b Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-24 Pancreatic Neoplasms 24895587 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The miR-24 was the most significantly powerful miRNA that regulated series of important genes. other hsa-mir-24-1 Pancreatic Neoplasms 22761894 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We investigated this possibility by analysis of miR-24-1 expression profiles in parathyroid adenomatous tissues from MEN1 gene mutation carriers, in their sporadic non-MEN1 counterparts, and in normal parathyroid tissue. other hsa-mir-26a Pancreatic Neoplasms 26189069 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. other hsa-mir-26a-1 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-26a-1 Pancreatic Neoplasms 22245693 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. Forced expression of miR-26a significantly inhibited cell proliferation, invasion, migration and increased cell apoptosis, whereas knockdown of miR-26a obtained the opposite effect. other hsa-mir-26a-2 Pancreatic Neoplasms 22086681 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells. other hsa-mir-26a-2 Pancreatic Neoplasms 22245693 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. Forced expression of miR-26a significantly inhibited cell proliferation, invasion, migration and increased cell apoptosis, whereas knockdown of miR-26a obtained the opposite effect. other hsa-mir-27a Pancreatic Neoplasms 24479798 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our findings demonstrated that genistein plays a tumor suppressor role in part through inhibition of miR-27a in pancreatic cancer cells. other hsa-mir-29 Pancreatic Neoplasms 26095125 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pathophysiological role of microRNA-29 in pancreatic cancer stroma. other hsa-mir-29a Pancreatic Neoplasms 23900458 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA-29a induces resistance to gemcitabine through the Wnt/β-catenin signaling pathway in pancreatic cancer cells. other hsa-mir-29c Pancreatic Neoplasms 25863127 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patients. other hsa-mir-29c Pancreatic Neoplasms 26121640 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer. other hsa-mir-31 Pancreatic Neoplasms 22344632 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Both inhibition and enhanced expression of miR-31 lead to reduced migration and invasion of pancreatic cancer cells. other hsa-mir-34 Pancreatic Neoplasms 27060060 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis other hsa-mir-342 Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-34a Pancreatic Neoplasms 19714243 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 inhibits tumor-initiating cells. other hsa-mir-34a Pancreatic Neoplasms 23140286 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Genistein Inhibits Cell Growth and Induces Apoptosis Through Up-regulation of miR-34a in Pancreatic Cancer Cell other hsa-mir-34a Pancreatic Neoplasms 29295989 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer other hsa-mir-34a Pancreatic Neoplasms 17540599 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53. other hsa-mir-34a Pancreatic Neoplasms 21622730 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Two miRNA candidates known to be downregulated in the majority of pancreatic cancers were selected for nanovector delivery: miR-34a, which is a component of the p53 transcriptional network and regulates cancer stem cell survival, and the miR-143/145 cluster, which together repress the expression of KRAS2 and its downstream effector Ras-responsive element binding protein-1 (RREB1). other hsa-mir-34b Pancreatic Neoplasms 19714243 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 inhibits tumor-initiating cells. other hsa-mir-34c Pancreatic Neoplasms 19714243 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 inhibits tumor-initiating cells. other hsa-mir-375 Pancreatic Neoplasms 21779484 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 The miRNA is Potentially Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer other hsa-mir-486 Pancreatic Neoplasms 19475450 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-224 and miR-486 are associated with the progression of pancreatic ductal adenocarcinomas other hsa-mir-548d-1 Pancreatic Neoplasms 21946813 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA miR-548d Is a Superior Regulator in Pancreatic Cancer. other hsa-mir-548d-2 Pancreatic Neoplasms 21946813 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 MicroRNA miR-548d Is a Superior Regulator in Pancreatic Cancer. other hsa-mir-92a Pancreatic Neoplasms 24332650 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 miR-92a/DUSP10/JNK signalling axis promotes human pancreatic cancer cells proliferation. other hsa-mir-95 Pancreatic Neoplasms 26314585 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. other hsa-mir-96 Pancreatic Neoplasms 23752186 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis. other hsa-mir-99a Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-99b Pancreatic Neoplasms 25607660 disease of cellular proliferation DOID:1793 C25.0-.2 D010190 260350 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. other hsa-mir-155 Pancreatic Serous Cystic Neoplasm 23638815 disease of cellular proliferation DOID:3919 Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. other hsa-mir-21 Pancreatic Serous Cystic Neoplasm 23638815 disease of cellular proliferation DOID:3919 Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. other hsa-mir-708 Pancreatic Serous Cystic Neoplasm 23638815 disease of cellular proliferation DOID:3919 Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation. other hsa-mir-138-2 Panic Disorder 21168126 disease of mental health DOID:594 F41.0 D016584 167870 Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. other hsa-mir-148a Panic Disorder 21168126 disease of mental health DOID:594 F41.0 D016584 167870 Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. other hsa-mir-22 Panic Disorder 21168126 disease of mental health DOID:594 F41.0 D016584 167870 Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. other hsa-mir-22 Panic Disorder 26361067 disease of mental health DOID:594 F41.0 D016584 167870 This is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population. other hsa-mir-488 Panic Disorder 21168126 disease of mental health DOID:594 F41.0 D016584 167870 Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways. other hsa-mir-491 Panic Disorder 26361067 disease of mental health DOID:594 F41.0 D016584 167870 This is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population. other hsa-let-7a Parkinson Disease 23600457 nervous system disease DOID:14330 G20 D010300 PS168600 Furthermore, the lack of LRRK2 leads to an up-regulation of neuronal differentiation-inducing processes, including the Let-7a pathway. other hsa-mir-106a Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-126 Parkinson Disease 26047984 nervous system disease DOID:14330 G20 D010300 PS168600 Our study provides evidence for a general association of miRNAs with the cellular function and identity of SN DA neurons, and with deregulated gene expression networks and signaling pathways related to PD pathogenesis that may be sex-specific. other hsa-mir-133b Parkinson Disease 17761882 nervous system disease DOID:14330 G20 D010300 PS168600 Expression of one of these precursor miRNAs, miR-133b, was specifically enriched in the midbrain and deficient in the context of Parkinson's disease patient samples, as determined by ribonuclease (RNase) protection assays, qPCR, and Northern blotting for mature miR-133b. other hsa-mir-133b Parkinson Disease 24742361 nervous system disease DOID:14330 G20 D010300 PS168600 Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. other hsa-mir-133b Parkinson Disease 25218846 nervous system disease DOID:14330 G20 D010300 PS168600 Our observations suggest that miR-133b might be involved in ceruloplasmin dysmetabolism in PD patients and a further investigation is warranted to confirm this hypothesis. other hsa-mir-133b Parkinson Disease 22245218 nervous system disease DOID:14330 G20 D010300 PS168600 miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease. other hsa-mir-135a Parkinson Disease 27842305 nervous system disease DOID:14330 G20 D010300 PS168600 Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease. other hsa-mir-153 Parkinson Disease 26116522 nervous system disease DOID:14330 G20 D010300 PS168600 Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway. other hsa-mir-203 Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-34a Parkinson Disease 28259991 nervous system disease DOID:14330 G20 D010300 PS168600 The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells. other hsa-mir-376a Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-382 Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-433 Parkinson Disease 26070653 nervous system disease DOID:14330 G20 D010300 PS168600 Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population. other hsa-mir-433 Parkinson Disease 28986288 nervous system disease DOID:14330 G20 D010300 PS168600 Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease. other hsa-mir-4697 Parkinson Disease 27653855 nervous system disease DOID:14330 G20 D010300 PS168600 SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study. other hsa-mir-495 Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-543 Parkinson Disease 28260060 nervous system disease DOID:14330 G20 D010300 PS168600 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. other hsa-mir-7 Parkinson Disease 28986288 nervous system disease DOID:14330 G20 D010300 PS168600 Linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease. other hsa-mir-7-1 Parkinson Disease 23281385 nervous system disease DOID:14330 G20 D010300 PS168600 MiR-7 variation is not associated with PD in Chinese patients other hsa-mir-7-2 Parkinson Disease 23281385 nervous system disease DOID:14330 G20 D010300 PS168600 MiR-7 variation is not associated with PD in Chinese patients other hsa-mir-7-3 Parkinson Disease 23281385 nervous system disease DOID:14330 G20 D010300 PS168600 MiR-7 variation is not associated with PD in Chinese patients other hsa-mir-124 Pediatric Ependymoma 29383182 disease of cellular proliferation DOID:5509 The tumor suppressor, hsa-miR-124, was down regulated in pediatric SEPN and it normally represses genes involved in cell-cell communication and metabolic processes other hsa-mir-1321 Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. other hsa-mir-17 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-18 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-19a Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-19b-1 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-20a Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-513b Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. other hsa-mir-769 Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. other hsa-mir-92-1 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. other hsa-mir-340 Pediatric Osteosarcoma 24398981 disease of cellular proliferation DOID:3361 Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma. other hsa-mir-142 Periodontal Diseases 27429973 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. other hsa-mir-146a Periodontal Diseases 21263019 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 Polymicrobial Infection with Periodontal Pathogens Specifically enhances miR-146a in ApoE-/- Mice during Experimental Periodontal Disease. other hsa-mir-146a Periodontal Diseases 27429973 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. other hsa-mir-155 Periodontal Diseases 27429973 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. other hsa-mir-203 Periodontal Diseases 27429973 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. other hsa-mir-21 Periodontal Diseases 25203845 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells. other hsa-mir-223 Periodontal Diseases 27429973 gastrointestinal system disease DOID:3388 K05.6 D010510 HP:0000704 In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. other hsa-mir-17 Periodontitis 21898695 gastrointestinal system disease DOID:824 K05.4 D010518 260950 HP:0000704 MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients With Periodontitis. other hsa-mir-21 Peripheral Nerve Injury 25484256 D059348 miR-21 and miR-222 inhibited neuronal apoptosis at least partially through suppressing TIMP3 after peripheral nerve injury. other hsa-mir-222 Peripheral Nerve Injury 25484256 D059348 miR-21 and miR-222 inhibited neuronal apoptosis at least partially through suppressing TIMP3 after peripheral nerve injury. other hsa-mir-425 Peripheral Vascular Disease 27132035 cardiovascular system disease DOID:341 I73.9 D016491 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo other hsa-let-7d Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-100 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-107 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-129 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-132 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-136 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-146b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-148a Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-152 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-15a Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-15b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-160 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-192 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-193a Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-193b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-194 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-200a Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-200b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-203 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-205 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-21 Peritoneal Dialysis Failure 28495592 T85.71 miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. other hsa-mir-26b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-29b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-30a Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-30b Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-31 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-335 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-497 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-664 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-703 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-709 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-801 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-923 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-mir-93 Peritoneal Dialysis Failure 26495316 T85.71 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. other hsa-let-7 Perlman Syndrome 24141620 syndrome DOID:0060476 C536399 267000 Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs. other hsa-let-7 Perlman Syndrome 27498873 syndrome DOID:0060476 C536399 267000 we found that Dis3l2 specifically recognizes and degrades uridylated pre-let-7 microRNA other hsa-mir-17 Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-18 Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-19a Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-19b-1 Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-20a Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-92-1 Perlman Syndrome 26598317 syndrome DOID:0060476 C536399 267000 Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia. other hsa-mir-126a Persistent Fetal Circulation Syndrome 28148930 cardiovascular system disease DOID:13042 P29.3 D010547 265380 HP:0011726 MiR-126a-5p is involved in the hypoxia-induced endothelial-to-mesenchymal transition of neonatal pulmonary hypertension. other hsa-mir-101 Pheochromocytoma 25973039 C74.10 D010673 171300 HP:0002666 Role of miR-101 in pheochromocytoma patients with SDHD mutation. other hsa-mir-183 Pheochromocytoma 23660872 C74.10 D010673 171300 HP:0002666 We demonstrated that miR-183 and/or miR-96 impede NGF-induced differentiation in PC12 cells. other hsa-mir-96 Pheochromocytoma 23660872 C74.10 D010673 171300 HP:0002666 We demonstrated that miR-183 and/or miR-96 impede NGF-induced differentiation in PC12 cells. other hsa-mir-106b Pituitary Adenoma 28288092 disease of cellular proliferation DOID:3829 D35.2 D010911 102200 HP:0002893 Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT. other hsa-mir-185 Pituitary Adenoma 26036598 disease of cellular proliferation DOID:3829 D35.2 D010911 102200 HP:0002893 MiR-185 enhanced the cell proliferation and inhibited the apoptosis of GH3 cells. other hsa-mir-21 Pituitary Adenoma 22222153 disease of cellular proliferation DOID:3829 D35.2 D010911 102200 HP:0002893 We speculated the mechanism of miR-21 is involved in tumorigenesis, leading to improvements in therapies and prevention of metastasis. other hsa-mir-26a-1 Pituitary Adenoma 23525216 disease of cellular proliferation DOID:3829 D35.2 D010911 102200 HP:0002893 miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C other hsa-mir-26a-2 Pituitary Adenoma 23525216 disease of cellular proliferation DOID:3829 D35.2 D010911 102200 HP:0002893 miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C other hsa-let-7a-1 Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7a-2 Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7a-3 Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7b Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7b: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7c Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7c: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7d Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7d: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7e Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7e: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7f-1 Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7f: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7f-2 Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7f: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7g Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7g: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-let-7i Pituitary Neoplasms 19136928 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 let-7i: Overexpression of HMGA2 relates to reduction of the let-7 other hsa-mir-106b Pituitary Neoplasms 25862551 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma. other hsa-mir-17 Pituitary Neoplasms 25862551 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma. other hsa-mir-20a Pituitary Neoplasms 25862551 disease of cellular proliferation DOID:1785 C75.1 D010911 HP:0040277 Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma. other hsa-let-7a Pleural Mesothelioma 25756049 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. other hsa-mir-125a Pleural Mesothelioma 25756049 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. other hsa-mir-145 Pleural Mesothelioma 24240684 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma. other hsa-mir-193a Pleural Mesothelioma 26125439 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. other hsa-mir-21 Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-21 Pleural Mesothelioma 28125734 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 MiR-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth other hsa-mir-221 Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-222 Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-223 Pleural Mesothelioma 25824152 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma. other hsa-mir-23a Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-30e Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-31 Pleural Mesothelioma 25497279 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. other hsa-mir-320 Pleural Mesothelioma 25756049 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. other hsa-mir-34b Pleural Mesothelioma 24553485 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma. other hsa-mir-34c Pleural Mesothelioma 24553485 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma. other hsa-mir-484 Pleural Mesothelioma 25756049 disease of cellular proliferation DOID:7474 C45.0 D054363 HP:0100002 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. other hsa-mir-146a Pneumonia 26984146 respiratory system disease DOID:552 J18.9 D011014 HP:0002090 pneumococci recognition induces a negative feedback loop, preventing excessive inflammation via miR-146a and potentially other miRNAs. other hsa-mir-17 Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-17 Polycystic Kidney Disease 27512774 Q61.19 D007690 PS173900 HP:0000113 One of the mechanisms through which the miR-17~92 cluster aggravates to cyst growth is by promoting proliferation of the cyst epithelial cells. other hsa-mir-18a Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-193b Polycystic Kidney Disease 28077374 Q61.19 D007690 PS173900 HP:0000113 Expression of ErbB4 in vivo was increased in human ADPKD and Pkd1 cystic kidneys, both transcriptionally and posttranscriptionally by mir-193b-3p other hsa-mir-19a Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-19b-1 Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-20a Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-92a-1 Polycystic Kidney Disease 23759744 Q61.19 D007690 PS173900 HP:0000113 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. other hsa-mir-103 Polycystic Ovarian Syndrome 24037889 syndrome DOID:11612 E28.2 D011085 184700 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. other hsa-mir-155 Polycystic Ovarian Syndrome 24037889 syndrome DOID:11612 E28.2 D011085 184700 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. other hsa-mir-21 Polycystic Ovarian Syndrome 24037889 syndrome DOID:11612 E28.2 D011085 184700 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. other hsa-mir-27b Polycystic Ovarian Syndrome 24037889 syndrome DOID:11612 E28.2 D011085 184700 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. other hsa-mir-21 Polycythemia Vera 28522758 hematopoietic system disease DOID:8997 D45 D011087 263300 Decreased CAT results from hypoxia-induced miR-21 that downregulates CAT other hsa-mir-222 Polycythemia Vera 17976518 hematopoietic system disease DOID:8997 D45 D011087 263300 Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11. other hsa-mir-339 Polycythemia Vera 17976518 hematopoietic system disease DOID:8997 D45 D011087 263300 biphasic regulation other hsa-mir-378a Polycythemia Vera 17976518 hematopoietic system disease DOID:8997 D45 D011087 263300 Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11. other hsa-mir-181 Porcine Reproductive and Respiratory Syndrome Virus Infection 23152505 As expected, miR-181 and other potential PRRSV-targeting miRNAs (such as miR-206) are expressed much more abundantly in minimally permissive cells or tissues than in highly permissive cells or tissues. other hsa-mir-26b Posterior Capsule Opacification 25063219 H26.40 D058442 MiRNA-26b inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells. other hsa-mir-1 Preeclampsia 28466998 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. other hsa-mir-155 Preeclampsia 28471953 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Association of microRNA-155, interleukin 17A, and proteinuria in preeclampsia. other hsa-mir-195 Preeclampsia 28466998 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. other hsa-mir-210 Preeclampsia 21388516 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Elevated levels of hypoxia-inducible microRNA-210 in preeclampsia. other hsa-mir-210 Preeclampsia 22840297 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. other hsa-mir-210 Preeclampsia 27529341 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Some of the most frequently differentially expressed miRs in PE include miR-210, miR-223 and miR-126/126* which associate strongly with the etiological domains of hypoxia, immunology and angiogenesis. other hsa-mir-210 Preeclampsia 27683514 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Predictive value of miR-210 as a novel biomarker for pre-eclampsia: a systematic review protocol. other hsa-mir-210 Preeclampsia 27746364 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia. other hsa-mir-22 Preeclampsia 28193709 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. other hsa-mir-29b Preeclampsia 28466998 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. other hsa-mir-29b-1 Preeclampsia 22716646 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 MicroRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells. other hsa-mir-29b-2 Preeclampsia 22716646 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 MicroRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells. other hsa-mir-34a Preeclampsia 24081307 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 The results support a role for miR-34a in the pathophysiology of preeclampsia, through deregulation of the pri-miRNA expression and its altered maturation. other hsa-mir-494 Preeclampsia 25660325 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE. other hsa-mir-942 Preeclampsia 28287888 cardiovascular system disease DOID:10591 O14 D011225 PS189800 HP:0100602 MiR-942 decreased before 20 weeks gestation in women with preeclampsia and was associated with the pathophysiology of preeclampsia in vitro. other hsa-let-7a Pregnancy Complications [unspecific] 25965838 D011248 For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays. other hsa-mir-132 Pregnancy Complications [unspecific] 25965838 D011248 For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays. other hsa-mir-146a Pregnancy Complications [unspecific] 25965838 D011248 For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays. other hsa-mir-155 Pregnancy Complications [unspecific] 25965838 D011248 For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays. other hsa-mir-16 Pregnancy Complications [unspecific] 25965838 D011248 For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays. other hsa-mir-4286 Pregnancy Complications [unspecific] 26418635 D011248 The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy. other hsa-mir-575 Pregnancy Complications [unspecific] 26418635 D011248 The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy. other hsa-mir-133a Preterm Labor 27452435 O60 D007752 IAI is associated with a transcriptional signature consistent with acute inflammation in the villous trophoblast. other hsa-mir-143 Preterm Labor 28596604 O60 D007752 miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. other hsa-mir-145 Preterm Labor 28596604 O60 D007752 miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation. other hsa-mir-18a Preterm Labor 27452440 O60 D007752 MALP-2 did not cause apoptosis but did lead to significant secretion of IL-4, IL-6, and IL-8 (P < 0.05, 0.01, 0.001, respectively) and significant changes in miRNA-320a and miRNA-18a (P < 0.05). other hsa-mir-139 Primary Biliary Cirrhosis 27668889 immune system disease DOID:12236 K74.5 D008105 PS109720 HP:0002613 MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis. other hsa-mir-146a Prion Diseases 22363497 nervous system disease DOID:649 A81.9 D017096 MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State. other hsa-let-7a Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-let-7a-1 Prostate Neoplasms 21148031 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 RPS2 control let-7a expression in human prostate cancer. other hsa-let-7c Prostate Neoplasms 19372056 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 β3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies. other hsa-let-7d Prostate Neoplasms 21548940 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d. other hsa-mir-1 Prostate Neoplasms 24222130 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In 22Rv1 cells, all AR isoforms were co-regulated by the cytoprotective factor HSPB1 and the tumor suppressor miR-1. Notably, our data provide evidence that HSPB1 inhibition is able to target expression of long as well as of short AR isoforms. other hsa-mir-1 Prostate Neoplasms 24391925 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Coordinate microRNA-mediated regulation of protein complexes in prostate cancer. other hsa-mir-1 Prostate Neoplasms 24982356 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells. other hsa-mir-100 Prostate Neoplasms 21212412 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. other hsa-mir-100 Prostate Neoplasms 19372056 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 β3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies. other hsa-mir-100 Prostate Neoplasms 23503652 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. other hsa-mir-101 Prostate Neoplasms 26067553 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer. other hsa-mir-101-1 Prostate Neoplasms 19285253 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-101: decrease of miR-101 leads to the overexpression of EZH2 other hsa-mir-101-1 Prostate Neoplasms 21430074 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. other hsa-mir-101-2 Prostate Neoplasms 19285253 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-101: decrease of miR-101 leads to the overexpression of EZH2 other hsa-mir-101-2 Prostate Neoplasms 21430074 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. other hsa-mir-106b Prostate Neoplasms 24135225 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Down-regulation of RE-1 silencing transcription factor (REST) in advanced prostate cancer by hypoxia-induced miR-106b~25. other hsa-mir-1227 Prostate Neoplasms 24091630 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Large oncosomes enhanced migration of cancer-associated fibroblasts (CAFs), an effect that was increased by miR-1227, a miRNA abundant in large oncosomes produced by RWPE-2 cells. other hsa-mir-124 Prostate Neoplasms 25115393 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. other hsa-mir-124 Prostate Neoplasms 24913567 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 It was clear that PACE4 level was closely associated with malignancy and invasiveness of PCa in vivo or in vitro MiR-124, played a crucial role inhibiting PACE4 transcription thus exhibiting obvious effects of antiproliferation and antiaggression of PCa. other hsa-mir-125b Prostate Neoplasms 25597828 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies. other hsa-mir-125b Prostate Neoplasms 26544868 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Thus, the dual action of hsa-miR-125b as a tumor suppressor and hsa-miR-22 as an oncomiR contributed to prostate tumorigenesis by modulations in PI3K/AKT and MAPK/ERK signaling pathways, key pathways known to influence prostate cancer progression. other hsa-mir-125b Prostate Neoplasms 27305142 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. other hsa-mir-125b Prostate Neoplasms 18056640 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP. other hsa-mir-125b Prostate Neoplasms 23503652 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. other hsa-mir-126 Prostate Neoplasms 25462564 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The regulation of these factors by miR-126 and miR-149 is essential for syndecan-1-mediated development of androgen-refractory prostate cancer. other hsa-mir-126 Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-1290 Prostate Neoplasms 25129854 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. other hsa-mir-1296 Prostate Neoplasms 20332239 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer other hsa-mir-130b Prostate Neoplasms 20875868 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-130b:The hsa-miR-130b also shows a high variance between samples. other hsa-mir-130b Prostate Neoplasms 24715691 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In addition to downregulation of the large tumor suppressor homolog2 and the programmed cell death protein 4, a neoplastic transformation inhibitor, the tumorigenic reprogramming of pASCs was associated with trafficking by PC cell-derived exosomes of oncogenic factors, including H-ras and K-ras transcripts, oncomiRNAs miR-125b, miR-130b, and miR-155 as well as the Ras superfamily of GTPases Rab1a, Rab1b, and Rab11a. other hsa-mir-130b Prostate Neoplasms 20890088 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We recommend using hsa-miR-130b or the geometric mean of hsa-miR-130b and small RNA RNU6-2 for normalization in miRNA expression studies of prostate cancer. other hsa-mir-133a Prostate Neoplasms 26089375 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer. other hsa-mir-133b Prostate Neoplasms 24610824 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-133b might enhance tumor-promoting properties in less aggressive LNCaP cells, whereas this miR may act as a tumor suppressor in more aggressive PC-3 cells. miR-133b and RB1CC1 were independent prognostic indicators for prostate cancer. other hsa-mir-138 Prostate Neoplasms 25116803 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 伪-solanine downregulates oncogenic microRNA-21 (miR-21) and upregulates tumor suppressor miR-138 expression. other hsa-mir-141 Prostate Neoplasms 24195675 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Sensitive detection of microRNA in complex biological samples via enzymatic signal amplification using DNA polymerase coupled with nicking endonuclease. other hsa-mir-141 Prostate Neoplasms 21723797 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-141 demonstrated high correlation with changes of the other biomarkers. other hsa-mir-141 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-143 Prostate Neoplasms 21647377 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRs-143 and -145 are associated with bone metastasis of prostate cancer and involved in the regulation of EMT. other hsa-mir-143 Prostate Neoplasms 22505520 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The authors experientially validated the miRNA-KLK interaction by transfecting miR-331-3p and miR-143 into a PCa cell line. other hsa-mir-143 Prostate Neoplasms 22948942 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. other hsa-mir-143 Prostate Neoplasms 23321517 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer other hsa-mir-143 Prostate Neoplasms 22929553 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set. other hsa-mir-145 Prostate Neoplasms 25969144 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis. other hsa-mir-145 Prostate Neoplasms 26089375 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer. other hsa-mir-145 Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-145 Prostate Neoplasms 26582710 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Re: A Feedback Regulation between miR-145 and DNA Methyltransferase 3b in Prostate Cancer Cell and Their Responses to Irradiation. other hsa-mir-145 Prostate Neoplasms 19996289 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-145 and miR-331-3p are predicted to target 3 of the 20 hub genes other hsa-mir-145 Prostate Neoplasms 21360565 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer. other hsa-mir-145 Prostate Neoplasms 21647377 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRs-143 and -145 are associated with bone metastasis of prostate cancer and involved in the regulation of EMT. other hsa-mir-145 Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-145 Prostate Neoplasms 22948942 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. other hsa-mir-145 Prostate Neoplasms 23404342 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145 other hsa-mir-145 Prostate Neoplasms 28641312 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. other hsa-mir-145 Prostate Neoplasms 28843521 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR. other hsa-mir-146a Prostate Neoplasms 21980038 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Microdissected epithelial structures with CgA-positive cell clusters exhibited a more than 5- and 7-fold lower expression of miR-146a and miR-146b-5p than their CgA-negative counterparts. As focal basal cell layer disruptions and the reduction or loss of miR-146a and miR-146b-5p has been documented to correlate with prostate tumor invasion and hormone refractoriness, our findings suggest that aberrant CgA expression in epithelial structures with FBCLD may represent an early sign of these events. other hsa-mir-146b Prostate Neoplasms 27273955 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-146b acts as a potential tumor suppressor in human prostate cancer. other hsa-mir-146b Prostate Neoplasms 24301753 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 After Gene Set Functional Similarity analysis, we obtained 20 abnormal PC-related candidate miRNAs, including hsa-miR-26a, hsa-miR-152, hsa-miR-19a, hsa-miR-30c, hsa-miR-19b, and hsa-miR-146b-5p, among others. other hsa-mir-148a Prostate Neoplasms 24337069 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. other hsa-mir-148a Prostate Neoplasms 26843836 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 decreased expressions of tumor suppressors: miR-34a, miR-143, miR-148a and miR-200 family are involved in resistance of anti-cancer drugs other hsa-mir-149 Prostate Neoplasms 25462564 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The regulation of these factors by miR-126 and miR-149 is essential for syndecan-1-mediated development of androgen-refractory prostate cancer. other hsa-mir-150 Prostate Neoplasms 25778313 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-150 is a factor of survival in prostate cancer patients. other hsa-mir-151a Prostate Neoplasms 22928040 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151. other hsa-mir-151b Prostate Neoplasms 22928040 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151. other hsa-mir-152 Prostate Neoplasms 25004396 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1. other hsa-mir-154 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-155 Prostate Neoplasms 25283513 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer. other hsa-mir-16 Prostate Neoplasms 24391925 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Coordinate microRNA-mediated regulation of protein complexes in prostate cancer. other hsa-mir-16 Prostate Neoplasms 25750034 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 This study highlights that commonly used endogenous controls can be responsive to radiation and validation is required prior to gene/miRNAs expression studies. other hsa-mir-16 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-16 Prostate Neoplasms 27305142 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. other hsa-mir-16-1 Prostate Neoplasms 21539977 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score. other hsa-mir-16-1 Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-16-2 Prostate Neoplasms 21539977 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score. other hsa-mir-16-2 Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-17 Prostate Neoplasms 21203553 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes. other hsa-mir-17 Prostate Neoplasms 19771525 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection. other hsa-mir-182 Prostate Neoplasms 19267923 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-182: with high analytical sensitivity and specificity other hsa-mir-182 Prostate Neoplasms 26870290 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells, and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182. other hsa-mir-182 Prostate Neoplasms 22929553 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set. other hsa-mir-183 Prostate Neoplasms 25409297 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. other hsa-mir-183 Prostate Neoplasms 25556023 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 the regulation of prostate-specific antigen and may eventually affect clinical decision making in prostate cancer. other hsa-mir-185 Prostate Neoplasms 23951060 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. other hsa-mir-18a Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-191 Prostate Neoplasms 26078486 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our results proved miR-191 to be the most stable gene, showing the lowest degree of variation and the highest stability value.miR-25 and SNORD48 values fell beyond the cutoff of acceptability. In conclusion,we recommend the use of miR-191 for normalization purposes in post-DRE urine sediments. other hsa-mir-193a Prostate Neoplasms 22438885 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-193a-3p and miRPlus-E1245 observed to be specific to XMRV infection in all 4 cell types (Two prostate cell lines (LNCaP and DU145) and two primary cells). other hsa-mir-193a Prostate Neoplasms 29216925 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel. other hsa-mir-195 Prostate Neoplasms 21539977 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score. other hsa-mir-19b Prostate Neoplasms 27305142 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. other hsa-mir-200 Prostate Neoplasms 24193225 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model. other hsa-mir-200b Prostate Neoplasms 24391862 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-200b inhibits prostate cancer EMT, growth and metastasis. other hsa-mir-200b Prostate Neoplasms 25597828 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies. other hsa-mir-200b Prostate Neoplasms 24337069 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. other hsa-mir-200b Prostate Neoplasms 23389960 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Down-regulation of miR-200b-3p by low p73 contributes to the androgen-independence of prostate cancer cells other hsa-mir-200c Prostate Neoplasms 25363395 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and the corresponding mechanism. other hsa-mir-200c Prostate Neoplasms 25597828 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies. other hsa-mir-200c Prostate Neoplasms 24646496 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Words of wisdom: Re: TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. other hsa-mir-200c Prostate Neoplasms 21431706 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Differentially expressed between androgen-dependent and androgen-independent metastatic prostate cancer cells other hsa-mir-200c Prostate Neoplasms 23041061 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205 other hsa-mir-203 Prostate Neoplasms 25004126 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. other hsa-mir-203 Prostate Neoplasms 25409297 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. other hsa-mir-203 Prostate Neoplasms 21159887 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-203 expression is specifically attenuated in bone metastatic prostate cancer suggesting a fundamental anti-metastatic role for this miRNA other hsa-mir-203 Prostate Neoplasms 21368580 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. other hsa-mir-203 Prostate Neoplasms 26976978 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 increase of miR-203 expression after ZA exposure other hsa-mir-204 Prostate Neoplasms 27438705 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 It is believed that miR-204 acts as a tumor-suppressor via promoting apoptosis, conferring the resistance of cancer cells to chemotherapy, and suppressing the self-renewal of cancer stem cells (CSCs) and the epithelial to mesenchymal transition (EMT). other hsa-mir-204 Prostate Neoplasms 29228612 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway other hsa-mir-205 Prostate Neoplasms 24370341 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells. other hsa-mir-205 Prostate Neoplasms 25409297 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. other hsa-mir-205 Prostate Neoplasms 19244118 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-205: miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon other hsa-mir-205 Prostate Neoplasms 21431706 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Differentially expressed between androgen-dependent and androgen-independent metastatic prostate cancer cells other hsa-mir-205 Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-205 Prostate Neoplasms 23041061 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205 other hsa-mir-205 Prostate Neoplasms 27305142 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. other hsa-mir-205 Prostate Neoplasms 20737563 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. other hsa-mir-205 Prostate Neoplasms 21368878 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. other hsa-mir-205 Prostate Neoplasms 22815235 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Additionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b. other hsa-mir-208 Prostate Neoplasms 26032092 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation. other hsa-mir-20a Prostate Neoplasms 24337069 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. other hsa-mir-21 Prostate Neoplasms 25409297 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. other hsa-mir-21 Prostate Neoplasms 19267923 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-21: with high analytical sensitivity and specificity other hsa-mir-21 Prostate Neoplasms 19597470 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 acts as tumor suppressor and induces apoptosis of tumor cells through E2F1-mediated suppression of Akt phosphorylation other hsa-mir-21 Prostate Neoplasms 20092645 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 oncogenic properties of miR-21 could be cell and tissue dependent other hsa-mir-21 Prostate Neoplasms 20160498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer other hsa-mir-21 Prostate Neoplasms 23272133 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway other hsa-mir-21 Prostate Neoplasms 23353719 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases other hsa-mir-21 Prostate Neoplasms 25116803 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 伪-solanine downregulates oncogenic microRNA-21 (miR-21) and upregulates tumor suppressor miR-138 expression. other hsa-mir-21 Prostate Neoplasms 28467474 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Tonic suppression of PCAT29 by the IL-6 signaling pathway in prostate cancer: Reversal by resveratrol. other hsa-mir-210 Prostate Neoplasms 25091736 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Senescent stroma promotes prostate cancer progression: the role of miR-210. other hsa-mir-210 Prostate Neoplasms 28693582 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway. other hsa-mir-212 Prostate Neoplasms 26439987 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In conclusion, our study indicates a functional role of miR-212 in PCa and suggests the development of miR-212 based therapies. other hsa-mir-218 Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-218 Prostate Neoplasms 19372056 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 β3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies. other hsa-mir-22 Prostate Neoplasms 26052614 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. other hsa-mir-210 Prostate Neoplasms 25846647 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Treatment with MIB led to an induction of miR-210 expression, a hypoxia-related miRNA other hsa-mir-221 Prostate Neoplasms 26164758 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells. other hsa-mir-221 Prostate Neoplasms 25846647 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 This observation indicates that this miRNA may have a more complex role in prostate cancer development than considered previously.Thus examining the effect of androgen receptor (AR) agonists and antagonists on miRNA expression can provide novel insights into the response of cells to androgen receptor (AR) ligands and subsequent downstream events. other hsa-mir-221 Prostate Neoplasms 19267923 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-221: with high analytical sensitivity and specificity other hsa-mir-221 Prostate Neoplasms 23353719 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases other hsa-mir-221 Prostate Neoplasms 29281088 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Combining radiation dose parameters with microRNA expression in PBLs may be useful for predicting acute gastrointestinal toxicity of radiation therapy, thus contributing to personalized treatment of prostate cancer other hsa-mir-222 Prostate Neoplasms 26164758 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells. other hsa-mir-222 Prostate Neoplasms 19267923 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-222: with high analytical sensitivity and specificity other hsa-mir-222 Prostate Neoplasms 23353719 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases other hsa-mir-223 Prostate Neoplasms 26552919 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 For the first time, we disclose that celastrol could induce miR-223 in breast and prostate cancer cells, and that inhibiting miR-223 could further reduce the living cells in celastrol-treated cancer cell lines. We thus provide a novel way to increase celastrol's anti-cancer effects. other hsa-mir-23a Prostate Neoplasms 26110567 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer. other hsa-mir-23b Prostate Neoplasms 25115396 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. other hsa-mir-23b Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-23b Prostate Neoplasms 23300597 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells other hsa-mir-23c Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-24-1 Prostate Neoplasms 25115396 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. other hsa-mir-25 Prostate Neoplasms 26078486 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our results proved miR-191 to be the most stable gene, showing the lowest degree of variation and the highest stability value.miR-25 and SNORD48 values fell beyond the cutoff of acceptability. In conclusion,we recommend the use of miR-191 for normalization purposes in post-DRE urine sediments. other hsa-mir-25 Prostate Neoplasms 25372501 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 These effects were strongly associated with changes in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25) other hsa-mir-25 Prostate Neoplasms 27305142 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. other hsa-mir-26a-1 Prostate Neoplasms 21539977 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score. other hsa-mir-26a-2 Prostate Neoplasms 21539977 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score. other hsa-mir-27b Prostate Neoplasms 25115396 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. other hsa-mir-27b Prostate Neoplasms 23300597 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells other hsa-mir-296 Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-299 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-29a Prostate Neoplasms 26052614 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. other hsa-mir-29b Prostate Neoplasms 22815235 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Additionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b. other hsa-mir-29b-1 Prostate Neoplasms 22402125 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling. other hsa-mir-29b-2 Prostate Neoplasms 22402125 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling. other hsa-mir-301a Prostate Neoplasms 25940439 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals. other hsa-mir-301a Prostate Neoplasms 26813459 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Taken together, we demonstrated that miR-301a/b-NDRG2 might be an important axis modulating autophagy and viability of prostate cancer cells under hypoxia. other hsa-mir-301b Prostate Neoplasms 26813459 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Taken together, we demonstrated that miR-301a/b-NDRG2 might be an important axis modulating autophagy and viability of prostate cancer cells under hypoxia. other hsa-mir-302a Prostate Neoplasms 25922934 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. other hsa-mir-30c Prostate Neoplasms 24452717 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-30c serves as an independent biochemical recurrence predictor and potential tumor suppressor for prostate cancer. other hsa-mir-30c Prostate Neoplasms 24301753 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 After Gene Set Functional Similarity analysis, we obtained 20 abnormal PC-related candidate miRNAs, including hsa-miR-26a, hsa-miR-152, hsa-miR-19a, hsa-miR-30c, hsa-miR-19b, and hsa-miR-146b-5p, among others. other hsa-mir-30d Prostate Neoplasms 23231923 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Identification of miR-30d as a novel prognostic maker of prostate cancer other hsa-mir-31 Prostate Neoplasms 29364469 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels other hsa-mir-31 Prostate Neoplasms 21368878 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. other hsa-mir-3176 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-32 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-323 Prostate Neoplasms 26160610 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data demonstrate that miR-323 may increase VEGF-A-mediated cancer vascularization in PC cells through AdipoR1 suppression. other hsa-mir-330 Prostate Neoplasms 19597470 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation other hsa-mir-331 Prostate Neoplasms 19996289 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-145 and miR-331-3p are predicted to target 3 of the 20 hub genes other hsa-mir-331 Prostate Neoplasms 21971048 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The RNA-binding protein HuR opposes the repression of ERBB-2 expression by miR-331-3p in prostate cancer cells. other hsa-mir-331 Prostate Neoplasms 22505520 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The authors experientially validated the miRNA-KLK interaction by transfecting miR-331-3p and miR-143 into a PCa cell line. other hsa-mir-335 Prostate Neoplasms 26647850 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 These findings suggested that miR-335 and -543 are associated with bone metastasis of PCa and indicated that they may have important roles in the bone metastasis, which may also be clinically used as novel biomarkers in discriminating the different stages of human PCa and predicting bone metastasis. other hsa-mir-335 Prostate Neoplasms 23456549 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data demonstrated for the first time the inhibitory effect of miR-335 on cell proliferation and invasion for PCa cells other hsa-mir-342 Prostate Neoplasms 23951060 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. other hsa-mir-34a Prostate Neoplasms 25053345 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 This study supports the extracellular environment as an important source of minimally invasive predictive biomarkers representing their cellular origin. Using miR-34a as example, we showed that biomarkers identified in this manner may also hold functional relevance. other hsa-mir-34a Prostate Neoplasms 26089375 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer. other hsa-mir-34a Prostate Neoplasms 26231042 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. other hsa-mir-34a Prostate Neoplasms 20687223 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MiR-34a:MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms other hsa-mir-34a Prostate Neoplasms 21980368 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis other hsa-mir-34a Prostate Neoplasms 22235332 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells. other hsa-mir-3654 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-3673 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-373 Prostate Neoplasms 25409297 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers. other hsa-mir-373 Prostate Neoplasms 25980442 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals. other hsa-mir-373 Prostate Neoplasms 21139802 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The oncogenic mi-croRNAs, miR-373 and miR-520c interact with CD44 in Prostate Cancer other hsa-mir-373 Prostate Neoplasms 18193036 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs. other hsa-mir-375 Prostate Neoplasms 25129854 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. other hsa-mir-375 Prostate Neoplasms 25597828 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies. other hsa-mir-375 Prostate Neoplasms 24337069 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. other hsa-mir-375 Prostate Neoplasms 28282880 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice. other hsa-mir-376a Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-376c Prostate Neoplasms 26163549 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines. other hsa-mir-376c Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-377 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-381 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-381 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-3915 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-409 Prostate Neoplasms 25065597 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis. other hsa-mir-424 Prostate Neoplasms 24193225 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model. other hsa-mir-424 Prostate Neoplasms 27820701 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. other hsa-mir-429 Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-429 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-449a Prostate Neoplasms 26081756 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer. other hsa-mir-449a Prostate Neoplasms 27250340 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Overexpression of miR-449a or knockdown of c-Myc promoted the sensitivity of LNCaP cells to IR. other hsa-mir-449b Prostate Neoplasms 25416653 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy. other hsa-mir-4723 Prostate Neoplasms 24223753 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases. other hsa-mir-485 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-487b Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-487b Prostate Neoplasms 28282880 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice. other hsa-mir-488 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-497 Prostate Neoplasms 23886135 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNA-497 suppresses proliferation and induces apoptosis in prostate cancer cells. other hsa-mir-497 Prostate Neoplasms 26415820 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed. other hsa-mir-5004 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-513c Prostate Neoplasms 26089375 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer. other hsa-mir-519d Prostate Neoplasms 21703393 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-519d,and miR-647 could be used to separate patients with and without biochemical recurrence other hsa-mir-520c Prostate Neoplasms 21139802 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 The oncogenic mi-croRNAs, miR-373 and miR-520c interact with CD44 in Prostate Cancer other hsa-mir-541 Prostate Neoplasms 25135278 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling. other hsa-mir-543 Prostate Neoplasms 26647850 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 These findings suggested that miR-335 and -543 are associated with bone metastasis of PCa and indicated that they may have important roles in the bone metastasis, which may also be clinically used as novel biomarkers in discriminating the different stages of human PCa and predicting bone metastasis. other hsa-mir-574 Prostate Neoplasms 23554959 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Genistein Up-Regulates Tumor Suppressor MicroRNA-574-3p in Prostate Cancer other hsa-mir-606 Prostate Neoplasms 27278879 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488鈥?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN). other hsa-mir-630 Prostate Neoplasms 24971999 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. other hsa-mir-647 Prostate Neoplasms 21703393 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-519d,and miR-647 could be used to separate patients with and without biochemical recurrence other hsa-mir-648 Prostate Neoplasms 24618011 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our analysis revealed the scale-free features of the human miRNA-mRNA interaction network and showed the distinctive topological features of existing cancer miRNA biomarkers from previously published studies. A novel cancer miRNA biomarker prediction framework was designed based on these observations and applied to prostate cancer study. This method could be applied for miRNA biomarker prediction in other cancers. other hsa-mir-650 Prostate Neoplasms 25956032 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression. other hsa-mir-654 Prostate Neoplasms 24166498 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. other hsa-mir-663 Prostate Neoplasms 24243035 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-663 induces castration-resistant prostate cancer transformation and predicts clinical recurrence. other hsa-mir-708 Prostate Neoplasms 22552290 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miRNA-708 control of CD44+ prostate cancer initiating cells. other hsa-mir-765 Prostate Neoplasms 24837491 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer. other hsa-mir-888 Prostate Neoplasms 24200968 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. other hsa-mir-888 Prostate Neoplasms 24457835 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. other hsa-mir-93 Prostate Neoplasms 25372501 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 These effects were strongly associated with changes in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25) other hsa-mir-96 Prostate Neoplasms 25333253 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia. other hsa-mir-96 Prostate Neoplasms 26089375 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer. other hsa-mir-96 Prostate Neoplasms 22929553 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set. other hsa-mir-99a Prostate Neoplasms 25937401 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 A combination of low Ku80 expression and highly-induced miR-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy. other hsa-mir-99a Prostate Neoplasms 21212412 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. other hsa-mir-99b Prostate Neoplasms 21212412 disease of cellular proliferation DOID:10283 C51 D011471 176807 HP:0100787 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. other hsa-mir-125b Psoriasis 18853072 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin) other hsa-mir-125b Psoriasis 27479112 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Based on our bioinformatical pipeline, ubiquitin-specific peptidase 2 was selected as a likely candidate for a mechanistic explanation for psoriasis association. other hsa-mir-146a Psoriasis 18853072 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin) other hsa-mir-146a Psoriasis 26559308 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 It is found that genetic polymorphisms related to some of specific miRNAs, miR-146a for example, are associated with psoriasis susceptibility. other hsa-mir-146a Psoriasis 27568078 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. other hsa-mir-146a Psoriasis 28595995 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. other hsa-mir-146b Psoriasis 28595995 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis. other hsa-mir-155 Psoriasis 28402921 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. other hsa-mir-17 Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-18 Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-193b Psoriasis 25431026 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of psoriasis. other hsa-mir-19a Psoriasis 24192448 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Our results indicated hair root miR-19a levels are effective as a disease marker. other hsa-mir-19a Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-19b-1 Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-203 Psoriasis 18853072 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin) other hsa-mir-20a Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-21 Psoriasis 18853072 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin) other hsa-mir-21 Psoriasis 23479230 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Mechanistic studies revealed a P2X7R-dependent mir-21 angiogenesis pathway that leads to the expression of vascular endothelial growth factor and IL-6 and that may be involved in the development of psoriatic lesions. other hsa-mir-21 Psoriasis 27586798 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 the activation of S100A8/A9-dependent C3 complement as well as a miR-21-dependent TIMP-3/TACE pathway leading to TNF-α shedding other hsa-mir-223 Psoriasis 25431026 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of psoriasis. other hsa-mir-31 Psoriasis 26138368 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. other hsa-mir-31 Psoriasis 27405090 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. other hsa-mir-92-1 Psoriasis 27579777 integumentary system disease DOID:8893 L40.9 D011565 PS177900 HP:0003765 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. other hsa-mir-424 Psoriatic Arthritis 24628460 syndrome DOID:9008 L40.5 D015535 607507 miR-424 levels in hair shaft are increased in psoriatic patients. other hsa-mir-146a Psychotic Disorders 23295264 F24 D011618 Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis other hsa-mir-212 Psychotic Disorders 23295264 F24 D011618 Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis other hsa-mir-130 Pulmonary Hypertension 26565914 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. other hsa-mir-130 Pulmonary Hypertension 25505270 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 olecular cross-talk among the diverse cellular populations involved in PH. other hsa-mir-130a Pulmonary Hypertension 25681685 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 These data suggest that miRNA family miR-130 plays an important role in the repression of CDKN1A by hypoxia.miR-130 enhances hypoxia-induced smooth muscle proliferation and might be involved in the development of right ventricular hypertrophy and vascular remodeling in pulmonary hypertension. other hsa-mir-145 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-17 Pulmonary Hypertension 23114789 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 MEX suppressed the hypoxic activation of signal transducer and activator of transcription 3 (STAT3) and the upregulation of the miR-17 superfamily of microRNA clusters, whereas it increased lung levels of miR-204, a key microRNA, the expression of which is decreased in human pulmonary hypertension. other hsa-mir-17 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-18 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-19a Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-19b-1 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-204 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Recent studies demonstrated the role of miR-204 and miR- 206 in pulmonary artery smooth muscle cell (PASMC) proliferation. other hsa-mir-204 Pulmonary Hypertension 24270264 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 We also showed that PARP-1 activation accounts for miR-204 downregulation (quantitative reverse transcription polymerase chain reaction) and the subsequent activation of the transcription factors nuclear factor of activated T cells and hypoxia-inducible factor 1-伪 in PAH-PASMCs, previously shown to be critical for PAH in several models. other hsa-mir-204 Pulmonary Hypertension 25006436 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Novel research shows that miR-204, a microRNA recently found to be notably downregulated through induction of PARP-1 (poly [ADP-ribose] polymerase 1) by excessive DNA damage in PAH, inhibits activation of STAT3. other hsa-mir-204 Pulmonary Hypertension 27438705 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers. other hsa-mir-206 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Recent studies demonstrated the role of miR-204 and miR- 206 in pulmonary artery smooth muscle cell (PASMC) proliferation. other hsa-mir-20a Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-21 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-21 Pulmonary Hypertension 28522568 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Peroxisome proliferator-activated receptor-γ enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. other hsa-mir-210 Pulmonary Hypertension 25825391 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. other hsa-mir-223 Pulmonary Hypertension 26084306 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 miR-223 reverses experimental pulmonary arterial hypertension. other hsa-mir-223 Pulmonary Hypertension 26201953 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on miR-223 reverses experimental pulmonary arterial hypertension. other hsa-mir-223 Pulmonary Hypertension 26815432 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Inhibition of miR-223 did not attenuate MCT PAH, whereas human prostacyclin synthase overexpression restored miRNA levels in MCT PAH to levels detected in naive rats. These data may establish a paradigm linking attenuation of PAH to restoration of BMPR2 signaling. other hsa-mir-26a Pulmonary Hypertension 24328779 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 miR-26a linked to pulmonary hypertension by global assessment of circulating extracellular microRNAs. other hsa-mir-27a Pulmonary Hypertension 27612006 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. other hsa-mir-301 Pulmonary Hypertension 26565914 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. other hsa-mir-301 Pulmonary Hypertension 25505270 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 olecular cross-talk among the diverse cellular populations involved in PH. other hsa-mir-451 Pulmonary Hypertension 25006399 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 In conclusion, transient inhibition of miR-451 attenuated the development of PAH in hypoxia-exposed rats. other hsa-mir-92-1 Pulmonary Hypertension 23713859 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. other hsa-mir-96 Pulmonary Hypertension 25871906 cardiovascular system disease DOID:6432 I27.20 D006976 PS178600 HP:0002092 Increased 5-HT1BR expression may be a consequence of decreased miRNA-96 expression in female patient human pulmonary artery smooth muscle cell(PASMCs), and this may contribute to the development of pulmonary arterial hypertension (PAH). other hsa-mir-143 Rectal Neoplasms 21567082 disease of cellular proliferation DOID:1984 D012004 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. other hsa-mir-145 Rectal Neoplasms 21567082 disease of cellular proliferation DOID:1984 D012004 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. other hsa-mir-153-1 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-153-2 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-16-1 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-16-2 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-21 Rectal Neoplasms 25496125 disease of cellular proliferation DOID:1984 D012004 miR-21-5p as a promising predictive biomarker, which should aid in the selection of patients with cCR to nCRT that potentially could be spared from radical surgery. other hsa-mir-21 Rectal Neoplasms 21567082 disease of cellular proliferation DOID:1984 D012004 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. other hsa-mir-519c Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-561 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-590 Rectal Neoplasms 22903298 disease of cellular proliferation DOID:1984 D012004 These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %. other hsa-mir-194 Rectum Adenocarcinoma 28870889 disease of cellular proliferation DOID:1996 C20 miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma. other hsa-mir-155 Recurrent Spontaneous Abortion 24739646 O03 D000022 The expression of miR-155 and HIF-1α is topically stimulated by oxygen signal.HIF-1α adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.The low expression of miR-155 could interfere with expression of HIF-1α and VEGF,which might be involved in villous vascular dysplasia in URSA. other hsa-mir-106b Renal Fibrosis 25094038 urinary system disease DOID:0050855 N26.9 HP:0030760 Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells. other hsa-mir-21 Renal Fibrosis 21852586 urinary system disease DOID:0050855 N26.9 HP:0030760 Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis. other hsa-mir-21 Renal Fibrosis 22344686 urinary system disease DOID:0050855 N26.9 HP:0030760 MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways. other hsa-mir-21 Renal Fibrosis 26415649 urinary system disease DOID:0050855 N26.9 HP:0030760 Collectively, these data present a unified model for a key role for miR-21 in the regulation of renal tubular extracellular matrix (ECM) synthesis and accumulation and provide important insights into the molecular pathways implicated in the progression of DN. other hsa-mir-21 Renal Fibrosis 23978520 urinary system disease DOID:0050855 N26.9 HP:0030760 Microvesicle-mediated delivery of miR-21 among tubular epithelial cells might shed new light on the mechanism of progressive renal fibrosis. other hsa-mir-214 Renal Fibrosis 24158985 urinary system disease DOID:0050855 N26.9 HP:0030760 MicroRNA-214 antagonism protects against renal fibrosis. other hsa-mir-215 Renal Fibrosis 25565137 urinary system disease DOID:0050855 N26.9 HP:0030760 MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease. other hsa-mir-29a Renal Fibrosis 21784902 urinary system disease DOID:0050855 N26.9 HP:0030760 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. other hsa-mir-29b-1 Renal Fibrosis 21784902 urinary system disease DOID:0050855 N26.9 HP:0030760 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. other hsa-mir-29b-2 Renal Fibrosis 21784902 urinary system disease DOID:0050855 N26.9 HP:0030760 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. other hsa-mir-29c Renal Fibrosis 26040904 urinary system disease DOID:0050855 N26.9 HP:0030760 Overall, miR-29c correlated with the degree of renal chronicity but not with renal function, suggesting it could be used as a novel non-invasive marker of early progression to fibrosis in patients with LN. other hsa-mir-29c Renal Fibrosis 21784902 urinary system disease DOID:0050855 N26.9 HP:0030760 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. other hsa-mir-378 Renal Fibrosis 28053239 urinary system disease DOID:0050855 N26.9 HP:0030760 miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling. other hsa-mir-382 Renal Fibrosis 20716515 urinary system disease DOID:0050855 N26.9 HP:0030760 The study provided experimental evidence in the form of reciprocal expression at the protein level for a large number of predicted miRNA-target pairs and discovered a novel role of miR-382 and SOD2 in the loss of epithelial characteristics induced by TGFβ1. other hsa-let-7i Respiratory Syncytial Virus Pneumonia 23249809 disease by infectious agent DOID:1273 J12.1 D018357 we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b other hsa-mir-24 Respiratory Syncytial Virus Pneumonia 26253191 disease by infectious agent DOID:1273 J12.1 D018357 Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β. other hsa-mir-30b Respiratory Syncytial Virus Pneumonia 23249809 disease by infectious agent DOID:1273 J12.1 D018357 we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b other hsa-mir-425 Respiratory System Disease 29535266 respiratory system disease DOID:1579 J98 Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p. other hsa-mir-200b Retinal Degeneration 27113191 nervous system disease DOID:8466 H35.40 D012162 605670 HP:0000546 Effect of MiR-200b on retinal endothelial cell function in high-glucose condition and the mechanism. other hsa-mir-200b Retinal Vascular Disease 28882646 nervous system disease DOID:2462 H35.06 HP:0012841 Protective effect of miR-200b/c by inhibiting vasohibin-2 in human retinal microvascular endothelial cells. other hsa-mir-200c Retinal Vascular Disease 28882646 nervous system disease DOID:2462 H35.06 HP:0012841 Protective effect of miR-200b/c by inhibiting vasohibin-2 in human retinal microvascular endothelial cells. other hsa-let-7a Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7a Retinoblastoma 21247883 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 E2F4 binding sites also occurred near regulatory elements for miRNAs such as let-7a and mir-17, suggestive of regulation of miRNAs by E2F4. Taken together, our genome-wide analysis provided evidence of versatile roles of E2F4 and insights into its functions. other hsa-let-7a-1 Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7a-2 Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7a-3 Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7b Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7b Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7c Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7c Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7d Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7d Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7e Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7e Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7f Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7f-1 Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7f-2 Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7g Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7g Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-let-7i Retinoblastoma 20004941 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. other hsa-let-7i Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-mir-15a Retinoblastoma 21454377 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death. other hsa-mir-15b Retinoblastoma 21454377 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death. other hsa-mir-16-1 Retinoblastoma 21454377 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death. other hsa-mir-16-2 Retinoblastoma 21454377 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death. other hsa-mir-17 Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-17 Retinoblastoma 22864477 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. other hsa-mir-17 Retinoblastoma 25513843 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells. other hsa-mir-17 Retinoblastoma 21247883 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 E2F4 binding sites also occurred near regulatory elements for miRNAs such as let-7a and mir-17, suggestive of regulation of miRNAs by E2F4. Taken together, our genome-wide analysis provided evidence of versatile roles of E2F4 and insights into its functions. other hsa-mir-18a Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-18a Retinoblastoma 22864477 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. other hsa-mir-18a Retinoblastoma 25513843 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells. other hsa-mir-18a Retinoblastoma 28481041 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. other hsa-mir-192 Retinoblastoma 21511813 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. other hsa-mir-19a Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-19b Retinoblastoma 25513843 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells. other hsa-mir-19b-1 Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-19b-1 Retinoblastoma 22864477 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. other hsa-mir-200a Retinoblastoma 26379276 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation. other hsa-mir-202 Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-mir-20a Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-20a Retinoblastoma 22864477 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. other hsa-mir-20a Retinoblastoma 17135249 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Altogether, these results suggest that the autoregulation between E2F1-3 and miR-20a is important for preventing an abnormal accumulation of E2F1-3 and may play a role in the regulation of cellular proliferation and apoptosis. other hsa-mir-21 Retinoblastoma 24607444 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Seed-targeting anti-miR-21 inhibiting malignant progression of retinoblastoma and analysis of their phosphorylation signaling pathways. other hsa-mir-21 Retinoblastoma 27600360 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 MiR-21 inhibitor suppressed the progression of retinoblastoma via the modulation of PTEN/PI3K/AKT pathway. other hsa-mir-221 Retinoblastoma 29843209 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. other hsa-mir-222 Retinoblastoma 29843209 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. other hsa-mir-31 Retinoblastoma 26379276 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation. other hsa-mir-34b Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-mir-34c Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-mir-376a-1 Retinoblastoma 23373993 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a other hsa-mir-376a-2 Retinoblastoma 23373993 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a other hsa-mir-494 Retinoblastoma 27399693 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 The overexpression of miR-494-3p in SAS cells increased the population of senescence-associated 尾-galactosidase positive cells, the expression of p16(INK4a) and retinoblastoma 1 (RB1), as well as downregulated Bmi1. other hsa-mir-92a-1 Retinoblastoma 21816922 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. other hsa-mir-92a-1 Retinoblastoma 22864477 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. other hsa-mir-98 Retinoblastoma 20019750 nervous system disease DOID:768 C69.20 D012175 180200 HP:0009919 miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma. other hsa-mir-133a Rhabdomyosarcoma 26153023 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 ARS treatment in ERMS cells ROS-dependently induces the expression of the myo-miRs, miR-133a and miR-206, which are down-regulated in RMS, and reduces PAX7 protein levels. other hsa-mir-206 Rhabdomyosarcoma 19620785 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 miR-1 was barely detectable in primary RMS other hsa-mir-206 Rhabdomyosarcoma 20502458 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 MicroRNA-206:MicroRNA-206 expression levels correlate with clinical behaviour of rhabdomyosarcomas other hsa-mir-206 Rhabdomyosarcoma 22541669 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells. other hsa-mir-206 Rhabdomyosarcoma 25644430 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. other hsa-mir-206 Rhabdomyosarcoma 27488535 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma. other hsa-mir-206 Rhabdomyosarcoma 29844345 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 SNAIL silencing induces myogenic differentiation by upregulation of myogenic factors and muscle-specific microRNAs, such as miR-206. other hsa-mir-34c Rhabdomyosarcoma 19620785 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 The muscle-specific microRNA miR-206, blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation other hsa-mir-9 Rhabdomyosarcoma 27984116 disease of cellular proliferation DOID:3247 M62.82 D012208 268220 HP:0002859 MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas. other hsa-mir-16 Rheumatic Myocarditis 29845432 disease by infectious agent DOID:8481 I01.9 significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis other hsa-mir-223 Rheumatic Myocarditis 29845432 disease by infectious agent DOID:8481 I01.9 significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis other hsa-mir-92a Rheumatic Myocarditis 29845432 disease by infectious agent DOID:8481 I01.9 significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis other hsa-mir-124a Rheumatoid Arthritis 19404929 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The results of this study suggest that miR-124a is a key miRNA in the posttranscriptional regulatory mechanisms of RA synoviocytes. other hsa-mir-125b Rheumatoid Arthritis 24778468 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis. other hsa-mir-126 Rheumatoid Arthritis 27465842 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 CCN1 induced VEGF expression in osteoblasts and increased endothelial progenitor cells (EPCs) angiogenesis by inhibiting miR-126 via the protein kinase C-alpha (PKC-伪) signaling pathway. other hsa-mir-146a Rheumatoid Arthritis 25630616 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 the miRNA-146 GG genotype might increase the risk of RA in females, and CC genotype may influence disease activity when evaluated with DAS28 score. other hsa-mir-146a Rheumatoid Arthritis 20840794 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 These results indicated that miR-146a was associated with IL-17 expression in the PBMC and synovium in RA patients. There is the possibility that miR-146a participates in the IL-17 expression. other hsa-mir-146a Rheumatoid Arthritis 22374446 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 In 2008, miR-146a and miR-155 were reported to be involved in the pathology of rheumatoid arthritis. other hsa-mir-146a Rheumatoid Arthritis 23291479 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development. other hsa-mir-146a Rheumatoid Arthritis 28514293 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The role of circulating miR-146a in patients with rheumatoid arthritis treated by Tripterygium wilfordii Hook F. other hsa-mir-155 Rheumatoid Arthritis 22374446 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 In 2008, miR-146a and miR-155 were reported to be involved in the pathology of rheumatoid arthritis. other hsa-mir-155 Rheumatoid Arthritis 23291479 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development. other hsa-mir-155 Rheumatoid Arthritis 26950427 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 epigenetic regulators such as micro-RNAs (i.e. miR-155) are key regulators of myeloid cells activation in RA other hsa-mir-155 Rheumatoid Arthritis 28118944 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis. other hsa-mir-155 Rheumatoid Arthritis 29575671 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 Rituximab may cause increased hepatitis C virus viremia in rheumatoid arthritis patients through declining exosomal microRNA-155 other hsa-mir-17 Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-18 Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-188 Rheumatoid Arthritis 26191188 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts. other hsa-mir-18a Rheumatoid Arthritis 23280137 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The TNFa-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-ж╩B signaling other hsa-mir-19a Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-19b-1 Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-203 Rheumatoid Arthritis 21279994 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 elevated levels of miR-203 lead to increased secretion of MMP-1 and IL-6 via the NF-kB pathway and thereby contribute to the activated phenotype of synovial fibroblasts in RA. other hsa-mir-20a Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-223 Rheumatoid Arthritis 24816316 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production. other hsa-mir-346 Rheumatoid Arthritis 21611196 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 miR-346 Controls Release of TNF-a Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization. other hsa-mir-451 Rheumatoid Arthritis 24401767 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs. other hsa-mir-92-1 Rheumatoid Arthritis 23516027 musculoskeletal system disease DOID:7148 M06.9 D001172 180300 HP:0001370 The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. other hsa-mir-124 Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-125b Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-146a Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-155 Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-181b Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-26b Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-92a Rhinosinusitis 26413631 B48.1 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. other hsa-mir-21 Salivary Gland Disease 29154818 gastrointestinal system disease DOID:10854 K11.9 MicroRNA-21 promotes wound healing via the Smad7-Smad2/3-Elastin pathway. other hsa-let-7 Salivary Gland Neoplasms 23774803 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-let-7a Salivary Gland Neoplasms 24853424 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 Furthermore, WIF1 significantly increased the expression of microRNAs pri-let-7a and pri-miR-200c, negative regulators of stemness and cancer progression. other hsa-mir-132 Salivary Gland Neoplasms 29108921 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors other hsa-mir-17 Salivary Gland Neoplasms 29108921 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors other hsa-mir-181a-2 Salivary Gland Neoplasms 23774803 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-mir-195 Salivary Gland Neoplasms 29108921 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors other hsa-mir-221 Salivary Gland Neoplasms 29108921 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors other hsa-mir-24 Salivary Gland Neoplasms 23774803 gastrointestinal system disease DOID:8850 C08 D012468 603641 HP:0100684 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas other hsa-mir-15 Salmonellosis 25146723 disease by infectious agent DOID:0060859 A02.0 D012480 Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. other hsa-mir-29a Salmonellosis 23826261 disease by infectious agent DOID:0060859 A02.0 D012480 Our study outlines for the first time important regulation pathways in intestinal Salmonella infection pointing out that focal adhesion and organisation of actin cytoskeleton are regulated by microRNAs. Functional relevance is shown by miR-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42. Further analysis of examined interactions may support the discovery of novel strategies impairing the uptake of intracellular pathogens. other hsa-mir-103-1 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-122 Schizophrenia 26575446 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Circulating miRNA biomarkers for schizophrenia other hsa-mir-124 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-130 Schizophrenia 26575446 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Circulating miRNA biomarkers for schizophrenia other hsa-mir-132 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-137 Schizophrenia 24556472 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells. other hsa-mir-137 Schizophrenia 24566148 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 miR-137: a new player in schizophrenia. other hsa-mir-137 Schizophrenia 25250332 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Association of a miRNA-137 polymorphism with schizophrenia in a Southern Chinese Han population. other hsa-mir-137 Schizophrenia 26005852 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The schizophrenia risk gene product miR-137 alters presynaptic plasticity. other hsa-mir-137 Schizophrenia 27650867 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. other hsa-mir-137 Schizophrenia 27706734 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis. other hsa-mir-138 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-144 Schizophrenia 19849891 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder. other hsa-mir-181 Schizophrenia 19849891 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder. other hsa-mir-19 Schizophrenia 27387650 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our study demonstrates the significance of posttranscriptional gene regulation by miR-19 in preventing the irregular migration of adult-born neurons that may contribute to the etiology of schizophrenia. other hsa-mir-195 Schizophrenia 19121517 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Using a postmortem case-control design, the association between BDNF protein, NPY/SST/PV mRNAs, and two BDNF-regulating microRNAs (miR-195 and miR-30a-5p) was determined in samples from the PFC of 20 schizophrenia and 20 control subjects. other hsa-mir-195 Schizophrenia 19849891 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder. other hsa-mir-195 Schizophrenia 22190509 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. other hsa-mir-198 Schizophrenia 18552348 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Human microRNAs (Hsa-mir-198 and Hsa-mir-206) are predicted to bind to influenza, rubella, or poliovirus genes. Certain genes associated with schizophrenia, including those also concerned with neurophysiology, are intimately related to the life cycles of the pathogens implicated in the disease. other hsa-mir-206 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-206 Schizophrenia 18552348 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Human microRNAs (Hsa-mir-198 and Hsa-mir-206) are predicted to bind to influenza, rubella, or poliovirus genes. Certain genes associated with schizophrenia, including those also concerned with neurophysiology, are intimately related to the life cycles of the pathogens implicated in the disease. other hsa-mir-218-1 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-26b Schizophrenia 26450699 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 the notion that microRNAs fine-tune the amount of proteins acting in the same biological pathways in schizophrenia, giving further support to the emerging theory of competing endogenous RNAs. other hsa-mir-29b Schizophrenia 27613806 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1. other hsa-mir-30a Schizophrenia 19121517 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Using a postmortem case-control design, the association between BDNF protein, NPY/SST/PV mRNAs, and two BDNF-regulating microRNAs (miR-195 and miR-30a-5p) was determined in samples from the PFC of 20 schizophrenia and 20 control subjects. other hsa-mir-30b Schizophrenia 20732949 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 These preliminary findings point to the possibility that disease-related changes in the expression of small noncoding RNAs such as miR-30b in schizophrenia could be influenced by gender and potentially regulated by estrogen signaling. other hsa-mir-30e Schizophrenia 27258654 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 miRNA-30e is associated with cognitive impairment in schizophrenia and depression. other hsa-mir-335 Schizophrenia 26450699 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 the notion that microRNAs fine-tune the amount of proteins acting in the same biological pathways in schizophrenia, giving further support to the emerging theory of competing endogenous RNAs. other hsa-mir-338 Schizophrenia 27892953 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion. other hsa-mir-346 Schizophrenia 19849891 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder. other hsa-mir-34a Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-34a Schizophrenia 19849891 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder. other hsa-mir-365 Schizophrenia 23876895 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed. other hsa-mir-449a Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-652 Schizophrenia 26575446 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Circulating miRNA biomarkers for schizophrenia other hsa-mir-7 Schizophrenia 25882257 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 MicroRNA-7/Shank3 axis involved in schizophrenia pathogenesis. other hsa-mir-9-3 Schizophrenia 25817407 disease of mental health DOID:5419 F20 D012559 181500 HP:0100753 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. other hsa-mir-21 Scleroderma, Systemic 27637490 musculoskeletal system disease DOID:418 M34 D012595 181750 Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis. other hsa-mir-29a Scleroderma, Systemic 24107002 musculoskeletal system disease DOID:418 M34 D012595 181750 Hair miR-29a levels are decreased in patients with scleroderma. other hsa-mir-29a Scleroderma, Systemic 25857445 musculoskeletal system disease DOID:418 M34 D012595 181750 MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. other hsa-mir-30b Scleroderma, Systemic 23893664 musculoskeletal system disease DOID:418 M34 D012595 181750 Down-regulation of miR-30b might be involved in the pathogenesis of SSc. other hsa-mir-155 Selective IgE Deficiency Disease 24734904 immune system disease DOID:6024 miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model. other hsa-mir-182 Sensorineural Hearing Loss 29476110 nervous system disease DOID:10003 H90.5 D006313 304400 A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis other hsa-mir-183 Sensorineural Hearing Loss 29476110 nervous system disease DOID:10003 H90.5 D006313 304400 A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis other hsa-mir-96 Sensorineural Hearing Loss 29476110 nervous system disease DOID:10003 H90.5 D006313 304400 A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis other hsa-mir-1 Sepsis 28673002 A41.9 D018805 HP:0100806 IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes. other hsa-mir-124 Sepsis 28342874 A41.9 D018805 HP:0100806 Activation of PPARγ inhibits pro-inflammatory cytokines production by upregulation of miR-124 in vitro and in vivo. other hsa-mir-135a Sepsis 28147298 A41.9 D018805 HP:0100806 MicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK/NF-κB pathway. other hsa-mir-143 Sepsis 24105952 A41.9 D018805 HP:0100806 The toll-like receptor 3 ligand, poly(I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143. other hsa-mir-146a Sepsis 23756365 A41.9 D018805 HP:0100806 Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. other hsa-mir-146a Sepsis 27596437 A41.9 D018805 HP:0100806 systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR-146a and miR-155, in the CSF Interestingly, this was associated with an increase in amount of multivesicular bodies (MVBs) and exosomes per MVB in the CPE cells other hsa-mir-146a Sepsis 28090688 A41.9 D018805 HP:0100806 Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis. other hsa-mir-150 Sepsis 26822049 A41.9 D018805 HP:0100806 Lower microRNA-150 may indicate a poor prognosis, and Picco monitoring combined with microRNA 150 detection may improve the prognostic efficiency in septic shock patients. other hsa-mir-155 Sepsis 24598292 A41.9 D018805 HP:0100806 The result of this study suggest that miR-155 is involved in the cell proliferation regulation of CD4(+)CD25(+) Treg cells, and play some role in the immunological dissonance in sepsis. other hsa-mir-155 Sepsis 26433115 A41.9 D018805 HP:0100806 A higher level of miR-155 indicated a more severe condition and poorer prognosis in sepsis patients. The possible underlying mechanism could be that miR-155 induces an increased percentage of CD39(+) Tregs and thus immunosuppression. other hsa-mir-155 Sepsis 27596437 A41.9 D018805 HP:0100806 systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR-146a and miR-155, in the CSF Interestingly, this was associated with an increase in amount of multivesicular bodies (MVBs) and exosomes per MVB in the CPE cells other hsa-mir-181b Sepsis 28934717 A41.9 D018805 HP:0100806 the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions other hsa-mir-21 Sepsis 28006751 A41.9 D018805 HP:0100806 miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. other hsa-mir-21 Sepsis 28437377 A41.9 D018805 HP:0100806 MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. other hsa-mir-21 Sepsis 28934717 A41.9 D018805 HP:0100806 the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions other hsa-mir-223 Sepsis 26348153 A41.9 D018805 HP:0100806 Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. other hsa-mir-223 Sepsis 28515178 A41.9 D018805 HP:0100806 A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. other hsa-mir-27a Sepsis 26171875 A41.9 D018805 HP:0100806 RhTNFR:Fc improved cardiac function of sepsis mice, and markedly decreased miR-27a but increased Nrf2 expression level of myocardium in LPS treated mice. other hsa-mir-375 Sepsis 28006751 A41.9 D018805 HP:0100806 miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. other hsa-mir-17 Severe Acute Respiratory Syndrome Virus Infection 19915717 disease by infectious agent DOID:2945 B97.21 D045169 Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination other hsa-mir-214 Severe Acute Respiratory Syndrome Virus Infection 19915717 disease by infectious agent DOID:2945 B97.21 D045169 Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination other hsa-mir-574 Severe Acute Respiratory Syndrome Virus Infection 19915717 disease by infectious agent DOID:2945 B97.21 D045169 Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination other hsa-mir-199a-2 Sezary Disease 22336940 disease of cellular proliferation DOID:8541 C84.1 D012751 Deep-Sequencing Analysis Reveals that the miR-199a2/214 Cluster within DNM3os Represents the Vast Majority of Aberrantly Expressed MicroRNAs in Sижzary Syndrome. other hsa-mir-214 Sezary Disease 22336940 disease of cellular proliferation DOID:8541 C84.1 D012751 Deep-Sequencing Analysis Reveals that the miR-199a2/214 Cluster within DNM3os Represents the Vast Majority of Aberrantly Expressed MicroRNAs in Sижzary Syndrome. other hsa-mir-214 Sezary Disease 27766406 disease of cellular proliferation DOID:8541 C84.1 D012751 CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214. other hsa-mir-199a-2 Sickle Cell Disease 27573019 D57 D000755 603903 Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. other hsa-mir-126 Sjogren Syndrome 28339625 immune system disease DOID:12894 M35.00 D012859 270150 Cystatin S-a candidate biomarker for severity of submandibular gland involvement in Sjögren's syndrome. other hsa-mir-146a Sjogren Syndrome 26505653 immune system disease DOID:12894 M35.00 D012859 270150 Dysregulated co-stimulatory molecule expression in a Sjögren's syndrome mouse model with potential implications by microRNA-146a. other hsa-mir-335 Sjogren Syndrome 28339625 immune system disease DOID:12894 M35.00 D012859 270150 Cystatin S-a candidate biomarker for severity of submandibular gland involvement in Sjögren's syndrome. other hsa-mir-150 Skin Disease [unspecific] 24530178 integumentary system disease DOID:37 L98.9 D012871 miR-150 levels were significantly decreased in sera of scleroderma patients, and were inversely correlated with the prevalence of pitting scars/ulcers and the incidence of anti-topoisomerase I antibody. other hsa-mir-23b Skin Neoplasms 24391759 disease of cellular proliferation DOID:4159 C44.90 D012878 HP:0008069 UVA and UVB irradiation differentially regulate microRNA expression in human primary keratinocytes. other hsa-mir-302a Skin Neoplasms 18755840 disease of cellular proliferation DOID:4159 C44.90 D012878 HP:0008069 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state other hsa-mir-302b Skin Neoplasms 18755840 disease of cellular proliferation DOID:4159 C44.90 D012878 HP:0008069 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state other hsa-mir-302c Skin Neoplasms 18755840 disease of cellular proliferation DOID:4159 C44.90 D012878 HP:0008069 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state other hsa-mir-302d Skin Neoplasms 18755840 disease of cellular proliferation DOID:4159 C44.90 D012878 HP:0008069 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state other hsa-mir-125b Spinal Cord Injuries 29461585 S34.139A D013119 MicroRNA-125b promotes the regeneration and repair of spinal cord injury through regulation of JAK/STAT pathway other hsa-mir-145 Spinal Cord Injuries 27907012 S34.139A D013119 The Signature of MicroRNA Dysregulation in Muscle Paralyzed by Spinal Cord Injury Includes Downregulation of MicroRNAs that Target Myostatin Signaling. other hsa-mir-182 Spinal Cord Injuries 28552531 S34.139A D013119 A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5. other hsa-mir-21 Spinal Cord Injuries 23238710 S34.139A D013119 microRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury other hsa-mir-210 Spinal Cord Injuries 27847197 S34.139A D013119 Synchrotron radiation micro-CT as a novel tool to evaluate the effect of agomir-210 in a rat spinal cord injury model. other hsa-mir-223 Spinal Cord Injuries 27432064 S34.139A D013119 Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223. other hsa-mir-23a Spinal Cord Injuries 27907012 S34.139A D013119 The Signature of MicroRNA Dysregulation in Muscle Paralyzed by Spinal Cord Injury Includes Downregulation of MicroRNAs that Target Myostatin Signaling. other hsa-mir-29b Spinal Cord Injuries 26097563 S34.139A D013119 Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury. other hsa-mir-494 Spinal Cord Injuries 28601045 S34.139A D013119 MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. other hsa-let-7a Spinal Cord Injuries 28552531 S34.139A D013119 A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5. other hsa-let-7 Squamous Cell Carcinoma 24070899 disease of cellular proliferation DOID:1749 D002294 Phospho-ΔNp63α regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation. other hsa-mir-193a Squamous Cell Carcinoma 21436470 disease of cellular proliferation DOID:1749 D002294 The resulting feed-forward circuit involving p63, miR-193a-5p and p73 controls p73 levels, cell viability and DNA damage susceptibility in certain cancers including squamous cell carcinoma. other hsa-mir-203 Squamous Cell Carcinoma 25284788 disease of cellular proliferation DOID:1749 D002294 Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. other hsa-mir-21 Squamous Cell Carcinoma 27371785 disease of cellular proliferation DOID:1749 D002294 Blueberry also modulated the expression of the oncomiR miR-21 and the tumor suppressor let-7. other hsa-mir-106a Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-143 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-143 Squamous Cell Carcinoma, Cerevial 26252302 endocrine system disease DOID:5531 A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study. other hsa-mir-145 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-145 Squamous Cell Carcinoma, Cerevial 26252302 endocrine system disease DOID:5531 A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study. other hsa-mir-15a Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-16-1 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-16-2 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-18b Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-195 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-19b-2 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-205 Squamous Cell Carcinoma, Cerevial 26864590 endocrine system disease DOID:5531 螖Np63伪 attenuates tumor aggressiveness by suppressing miR-205/ZEB1-mediated epithelial-mesenchymal transition in cervical squamous cell carcinoma. other hsa-mir-20b Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-363 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-497 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-92a-2 Squamous Cell Carcinoma, Cerevial 22472886 endocrine system disease DOID:5531 The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis. other hsa-mir-96 Squamous Cell Carcinoma, Cerevial 24791792 endocrine system disease DOID:5531 Expressions of MicroRNA-96 before and after chemotherapy and its relationship with chemosensitivity in cervical squamous cell carcinoma. other hsa-let-7e Squamous Cell Carcinoma, Esophageal 28408353 disease of cellular proliferation DOID:3748 C562729 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. other hsa-mir-100 Squamous Cell Carcinoma, Esophageal 25109390 disease of cellular proliferation DOID:3748 C562729 MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma. other hsa-mir-106b Squamous Cell Carcinoma, Esophageal 29552108 disease of cellular proliferation DOID:3748 C562729 miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC other hsa-mir-1179 Squamous Cell Carcinoma, Esophageal 25755718 disease of cellular proliferation DOID:3748 C562729 miR-1179 promotes cell invasion through SLIT2/ROBO1 axis in esophageal squamous cell carcinoma. other hsa-mir-125a Squamous Cell Carcinoma, Esophageal 28408353 disease of cellular proliferation DOID:3748 C562729 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. other hsa-mir-1290 Squamous Cell Carcinoma, Esophageal 25805931 disease of cellular proliferation DOID:3748 C562729 Our findings suggested that miR-1290 may play an oncogenic role in cellular processes of ESCC. other hsa-mir-133b Squamous Cell Carcinoma, Esophageal 28069586 disease of cellular proliferation DOID:3748 C562729 SQLE induces epithelial-to-mesenchymal transition by regulating of miR-133b in esophageal squamous cell carcinoma. other hsa-mir-139 Squamous Cell Carcinoma, Esophageal 24204738 disease of cellular proliferation DOID:3748 C562729 Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma. other hsa-mir-148a Squamous Cell Carcinoma, Esophageal 21246413 disease of cellular proliferation DOID:3748 C562729 Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells. other hsa-mir-150 Squamous Cell Carcinoma, Esophageal 26606907 disease of cellular proliferation DOID:3748 C562729 Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis. other hsa-mir-200b Squamous Cell Carcinoma, Esophageal 26334393 disease of cellular proliferation DOID:3748 C562729 These data highlight that suppression of the Kindlin-2-integrin β1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in ESCC. other hsa-mir-203 Squamous Cell Carcinoma, Esophageal 24692008 disease of cellular proliferation DOID:3748 C562729 MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo. other hsa-mir-203 Squamous Cell Carcinoma, Esophageal 24519530 disease of cellular proliferation DOID:3748 C562729 Research on the typical miRNA and target genes in squamous cell carcinoma and adenocarcinoma of esophagus cancer with DNA microarray. other hsa-mir-205 Squamous Cell Carcinoma, Esophageal 27974696 disease of cellular proliferation DOID:3748 C562729 Sp1-mediated transcriptional activation of miR-205 promotes radioresistance in esophageal squamous cell carcinoma. other hsa-mir-21 Squamous Cell Carcinoma, Esophageal 24039846 disease of cellular proliferation DOID:3748 C562729 MiR-21 expression is mostly confined to the SCC stroma and its release from fibroblasts influences the migration and invasion capacity of SCC cells. Moreover, miR-21 may be an important factor in activating fibroblasts to CAFs. These findings provide new insights into the role of CAFs and the extracellular matrix in tumor microenvironment formation and in tumor cell maintenance, and suggest miR-21 may contribute to cellular crosstalk in the tumor microenvironment. other hsa-mir-21 Squamous Cell Carcinoma, Esophageal 24519530 disease of cellular proliferation DOID:3748 C562729 Research on the typical miRNA and target genes in squamous cell carcinoma and adenocarcinoma of esophagus cancer with DNA microarray. other hsa-mir-210 Squamous Cell Carcinoma, Esophageal 21044961 disease of cellular proliferation DOID:3748 C562729 Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation. other hsa-mir-26a Squamous Cell Carcinoma, Esophageal 28476684 disease of cellular proliferation DOID:3748 C562729 miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway. other hsa-mir-26b Squamous Cell Carcinoma, Esophageal 28476684 disease of cellular proliferation DOID:3748 C562729 miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway. other hsa-mir-27a Squamous Cell Carcinoma, Esophageal 19960259 disease of cellular proliferation DOID:3748 C562729 miR-27a:Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma other hsa-mir-30a Squamous Cell Carcinoma, Esophageal 29259372 disease of cellular proliferation DOID:3748 C562729 Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway other hsa-mir-31 Squamous Cell Carcinoma, Esophageal 24039884 disease of cellular proliferation DOID:3748 C562729 Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. other hsa-mir-338 Squamous Cell Carcinoma, Esophageal 24039884 disease of cellular proliferation DOID:3748 C562729 Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. other hsa-mir-338 Squamous Cell Carcinoma, Esophageal 26004521 disease of cellular proliferation DOID:3748 C562729 MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo. other hsa-mir-34a Squamous Cell Carcinoma, Esophageal 26782413 disease of cellular proliferation DOID:3748 C562729 Clinical significance of microRNA-34a in esophageal squamous cell carcinoma. other hsa-mir-3651 Squamous Cell Carcinoma, Esophageal 26210449 disease of cellular proliferation DOID:3748 C562729 Clinical potential of miR-3651 as a novel prognostic biomarker for esophageal squamous cell cancer. other hsa-mir-383 Squamous Cell Carcinoma, Esophageal 26606907 disease of cellular proliferation DOID:3748 C562729 Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis. other hsa-mir-424 Squamous Cell Carcinoma, Esophageal 27628042 disease of cellular proliferation DOID:3748 C562729 MiR-424-5p participates in esophageal squamous cell carcinoma invasion and metastasis via SMAD7 pathway mediated EMT. other hsa-mir-498 Squamous Cell Carcinoma, Esophageal 28188753 disease of cellular proliferation DOID:3748 C562729 MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions. other hsa-mir-508 Squamous Cell Carcinoma, Esophageal 25099196 disease of cellular proliferation DOID:3748 C562729 miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma. other hsa-mir-630 Squamous Cell Carcinoma, Esophageal 27563011 disease of cellular proliferation DOID:3748 C562729 MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma. other hsa-mir-7 Squamous Cell Carcinoma, Esophageal 28314263 disease of cellular proliferation DOID:3748 C562729 Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. other hsa-mir-889 Squamous Cell Carcinoma, Esophageal 25841337 disease of cellular proliferation DOID:3748 C562729 miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. other hsa-mir-939 Squamous Cell Carcinoma, Esophageal 25346128 disease of cellular proliferation DOID:3748 C562729 Expression of microRNA-939 and its correlation with prognosis in esophageal squamous cell carcinoma. other hsa-mir-942 Squamous Cell Carcinoma, Esophageal 25844602 disease of cellular proliferation DOID:3748 C562729 miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway. other hsa-mir-98 Squamous Cell Carcinoma, Esophageal 27422937 disease of cellular proliferation DOID:3748 C562729 AmiR-98 mimic enforced the expression of miRNA-98 and made ESCC cells sensitive to radiotherapy, while anti-miR-98 reversed this process. other hsa-mir-99b Squamous Cell Carcinoma, Esophageal 28408353 disease of cellular proliferation DOID:3748 C562729 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. other hsa-let-7i Squamous Cell Carcinoma, Head and Neck 26257063 disease of cellular proliferation DOID:5520 C76.0 C535575 IB suppresses EMT and stemness of HNSCC cells through inhibition of Twist1-mediated let-7i downregulation and Rac1 activation and the EMT signalling. other hsa-mir-124 Squamous Cell Carcinoma, Head and Neck 26227488 disease of cellular proliferation DOID:5520 C76.0 C535575 miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma. other hsa-mir-1254 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-128 Squamous Cell Carcinoma, Head and Neck 25764126 disease of cellular proliferation DOID:5520 C76.0 C535575 Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis. other hsa-mir-138-1 Squamous Cell Carcinoma, Head and Neck 21770894 disease of cellular proliferation DOID:5520 C76.0 C535575 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. other hsa-mir-138-2 Squamous Cell Carcinoma, Head and Neck 21770894 disease of cellular proliferation DOID:5520 C76.0 C535575 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. other hsa-mir-141 Squamous Cell Carcinoma, Head and Neck 24424572 disease of cellular proliferation DOID:5520 C76.0 C535575 Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. other hsa-mir-146a Squamous Cell Carcinoma, Head and Neck 26621153 disease of cellular proliferation DOID:5520 C76.0 C535575 Characterizing the expression of miR-146a and miR-155 and their functional role in tumor biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in HNSCC. other hsa-mir-150 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-155 Squamous Cell Carcinoma, Head and Neck 26621153 disease of cellular proliferation DOID:5520 C76.0 C535575 Characterizing the expression of miR-146a and miR-155 and their functional role in tumor biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in HNSCC. other hsa-mir-16 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-193a Squamous Cell Carcinoma, Head and Neck 21293058 disease of cellular proliferation DOID:5520 C76.0 C535575 miR-193a-5p, expression of which was repressed by p63, was activated by proapoptotic p73 isoforms in both normal cells and tumor cells in vivo. other hsa-mir-193b Squamous Cell Carcinoma, Head and Neck 25677760 disease of cellular proliferation DOID:5520 C76.0 C535575 Alteration in miR-193b expression level does not show any significant association with cancer survival. other hsa-mir-200a Squamous Cell Carcinoma, Head and Neck 28677748 disease of cellular proliferation DOID:5520 C76.0 C535575 Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. other hsa-mir-200c Squamous Cell Carcinoma, Head and Neck 21294122 disease of cellular proliferation DOID:5520 C76.0 C535575 MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. other hsa-mir-200c Squamous Cell Carcinoma, Head and Neck 24424572 disease of cellular proliferation DOID:5520 C76.0 C535575 Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. other hsa-mir-21 Squamous Cell Carcinoma, Head and Neck 21685938 disease of cellular proliferation DOID:5520 C76.0 C535575 Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. other hsa-mir-21 Squamous Cell Carcinoma, Head and Neck 25175929 disease of cellular proliferation DOID:5520 C76.0 C535575 miR-21 increases the programmed cell death 4 gene-regulated cell proliferation in head and neck squamous carcinoma cell lines. other hsa-mir-21 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-210 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-29 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-34a Squamous Cell Carcinoma, Head and Neck 25762634 disease of cellular proliferation DOID:5520 C76.0 C535575 MiR-34a suppresses amphiregulin and tumor metastatic potential of head and neck squamous cell carcinoma (HNSCC). other hsa-mir-372 Squamous Cell Carcinoma, Head and Neck 25714028 disease of cellular proliferation DOID:5520 C76.0 C535575 miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. other hsa-mir-373 Squamous Cell Carcinoma, Head and Neck 26452218 disease of cellular proliferation DOID:5520 C76.0 C535575 Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy. other hsa-mir-375 Squamous Cell Carcinoma, Head and Neck 26172508 disease of cellular proliferation DOID:5520 C76.0 C535575 MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. other hsa-mir-376c Squamous Cell Carcinoma, Head and Neck 27760788 disease of cellular proliferation DOID:5520 C76.0 C535575 Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. other hsa-mir-93 Squamous Cell Carcinoma, Head and Neck 25578493 disease of cellular proliferation DOID:5520 C76.0 C535575 miR-93 may be a valuable marker for the prediction of metastasis and prognosis in HNSCC. other hsa-mir-93 Squamous Cell Carcinoma, Head and Neck 28677748 disease of cellular proliferation DOID:5520 C76.0 C535575 Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. other hsa-mir-106b Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 24846066 disease of cellular proliferation DOID:2876 miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma. other hsa-mir-125b Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 28693195 disease of cellular proliferation DOID:2876 MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility. other hsa-mir-148a Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 27859417 disease of cellular proliferation DOID:2876 RUNX3 inhibits laryngeal squamous cell carcinoma malignancy under the regulation of miR-148a-3p/DNMT1 axis. other hsa-mir-203 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 25840888 disease of cellular proliferation DOID:2876 Effect of microRNA-203 on tumor growth in human hypopharyngeal squamous cell carcinoma. other hsa-mir-203 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 24682952 disease of cellular proliferation DOID:2876 MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours. other hsa-mir-205 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 24297308 disease of cellular proliferation DOID:2876 MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma. other hsa-mir-205 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 28078305 disease of cellular proliferation DOID:2876 miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT. other hsa-mir-206 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 27279635 disease of cellular proliferation DOID:2876 co-transfection of miR-375 and miR-206 exhibited a less effective inhibitory effect other hsa-mir-21 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 24846066 disease of cellular proliferation DOID:2876 miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma. other hsa-mir-21 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 27545281 disease of cellular proliferation DOID:2876 MicroRNA-21 in laryngeal squamous cell carcinoma: Diagnostic and prognostic features. other hsa-mir-21 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 27688683 disease of cellular proliferation DOID:2876 Metformin significantly inhibited FaDu cell proliferation , possibly via downregulation of miR-21-5p and upregulation of PDCD4 other hsa-mir-23a Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 25879432 disease of cellular proliferation DOID:2876 miR-23a, an independent prognostic factor for laryngeal cancer,participates in the onset and progression of laryngeal cancer. other hsa-mir-375 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 24846066 disease of cellular proliferation DOID:2876 miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma. other hsa-mir-375 Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal 28078305 disease of cellular proliferation DOID:2876 miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT. other hsa-let-7a Squamous Cell Carcinoma, Lung 25802847 disease of cellular proliferation DOID:3907 C34.91 The novel candidate key drivers in this refined subnetwork, such as the methylation of ARHGDIB and HOXD3, microRNA let-7a and miR-31, and the CNV of AGAP2, were identified and analyzed. other hsa-let-7i Squamous Cell Carcinoma, Lung 20620595 disease of cellular proliferation DOID:3907 C34.91 let-7i:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC other hsa-mir-126 Squamous Cell Carcinoma, Lung 25521201 disease of cellular proliferation DOID:3907 C34.91 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. other hsa-mir-133a Squamous Cell Carcinoma, Lung 25518741 disease of cellular proliferation DOID:3907 C34.91 Further analysis of novel cancer signaling pathways modulated by the tumor-suppressive cluster miR-1/133a will provide insights into the molecular mechanisms of lung-SCC oncogenesis and metastasis other hsa-mir-141 Squamous Cell Carcinoma, Lung 25746592 disease of cellular proliferation DOID:3907 C34.91 MicroRNA-141 is a biomarker for progression of squamous cell carcinoma and adenocarcinoma of the lung: clinical analysis of 125 patients. other hsa-mir-145 Squamous Cell Carcinoma, Lung 27765924 disease of cellular proliferation DOID:3907 C34.91 Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. other hsa-mir-192 Squamous Cell Carcinoma, Lung 29571988 disease of cellular proliferation DOID:3907 C34.91 MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma other hsa-mir-205 Squamous Cell Carcinoma, Lung 25521201 disease of cellular proliferation DOID:3907 C34.91 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. other hsa-mir-375 Squamous Cell Carcinoma, Lung 28214218 disease of cellular proliferation DOID:3907 C34.91 Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma. other hsa-mir-661 Squamous Cell Carcinoma, Lung 19584273 disease of cellular proliferation DOID:3907 C34.91 miR-146b alone have the strongest prediction accuracy for stratifying prognostic groups; other hsa-mir-662 Squamous Cell Carcinoma, Lung 29571988 disease of cellular proliferation DOID:3907 C34.91 MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma other hsa-mir-98 Squamous Cell Carcinoma, Lung 25521201 disease of cellular proliferation DOID:3907 C34.91 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. other hsa-mir-375 Squamous Cell Carcinoma, Maxillary Sinus 21922130 disease of cellular proliferation DOID:7910 C31.0 Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. other hsa-mir-874 Squamous Cell Carcinoma, Maxillary Sinus 21847129 disease of cellular proliferation DOID:7910 C31.0 Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. other hsa-let-7d Squamous Cell Carcinoma, Oral 21725603 disease of cellular proliferation DOID:0050866 Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer. other hsa-mir-10b Squamous Cell Carcinoma, Oral 26544609 disease of cellular proliferation DOID:0050866 Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic. other hsa-mir-124 Squamous Cell Carcinoma, Oral 27889233 disease of cellular proliferation DOID:0050866 Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. other hsa-mir-126 Squamous Cell Carcinoma, Oral 24789258 disease of cellular proliferation DOID:0050866 Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro. other hsa-mir-138 Squamous Cell Carcinoma, Oral 28962163 disease of cellular proliferation DOID:0050866 miR-138 is able to inhibit the proliferation, migration and invasion of OSCC cell lines other hsa-mir-138 Squamous Cell Carcinoma, Oral 29088820 disease of cellular proliferation DOID:0050866 Knockdown of fascin in OSCC cells promoted cell adhesion and inhibited migration, invasion and EMT, and forced expression of miR-138 in OSCC cells significantly decreased the expression of fascin other hsa-mir-145 Squamous Cell Carcinoma, Oral 27557511 disease of cellular proliferation DOID:0050866 Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline. other hsa-mir-146a Squamous Cell Carcinoma, Oral 26159827 disease of cellular proliferation DOID:0050866 Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma. other hsa-mir-146a Squamous Cell Carcinoma, Oral 29269299 disease of cellular proliferation DOID:0050866 the activation of TLR2 by bacterial components can enhance the progression of OSCC and may be implicated in acquired resistance to cisplatin-induced apoptosis through regulation of the miR-146a pathway other hsa-mir-17 Squamous Cell Carcinoma, Oral 23602254 disease of cellular proliferation DOID:0050866 MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. other hsa-mir-194 Squamous Cell Carcinoma, Oral 25960215 disease of cellular proliferation DOID:0050866 miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling. other hsa-mir-196a Squamous Cell Carcinoma, Oral 26544609 disease of cellular proliferation DOID:0050866 Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic. other hsa-mir-200c Squamous Cell Carcinoma, Oral 26839311 disease of cellular proliferation DOID:0050866 suppression of the anti-inflammatory tumor suppressor microRNAs let-7d, miR-23b, and miR-200c was observed following PAR-2 stimulation. other hsa-mir-200c Squamous Cell Carcinoma, Oral 26879838 disease of cellular proliferation DOID:0050866 Sulforaphane treatment resulted in a dose-dependent increase in the levels of tumor suppressive miR200c. other hsa-mir-20a Squamous Cell Carcinoma, Oral 23602254 disease of cellular proliferation DOID:0050866 MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. other hsa-mir-21 Squamous Cell Carcinoma, Oral 24676554 disease of cellular proliferation DOID:0050866 STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo. other hsa-mir-21 Squamous Cell Carcinoma, Oral 25236707 disease of cellular proliferation DOID:0050866 Human papillomavirus-stratified analysis of the prognostic role of miR-21 in oral cavity and oropharyngeal squamous cell carcinoma. other hsa-mir-21 Squamous Cell Carcinoma, Oral 28314265 disease of cellular proliferation DOID:0050866 Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. other hsa-mir-210 Squamous Cell Carcinoma, Oral 28459203 disease of cellular proliferation DOID:0050866 Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma. other hsa-mir-221 Squamous Cell Carcinoma, Oral 21226887 disease of cellular proliferation DOID:0050866 miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. other hsa-mir-221 Squamous Cell Carcinoma, Oral 26796268 disease of cellular proliferation DOID:0050866 depleting cells of miR-221 increases the sensitivity of the cells to Adriamycin. other hsa-mir-222 Squamous Cell Carcinoma, Oral 21226887 disease of cellular proliferation DOID:0050866 miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. other hsa-mir-31 Squamous Cell Carcinoma, Oral 26544609 disease of cellular proliferation DOID:0050866 Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic. other hsa-mir-378 Squamous Cell Carcinoma, Oral 24120010 disease of cellular proliferation DOID:0050866 MicroRNA in oral squamous cell carcinoma other hsa-mir-491 Squamous Cell Carcinoma, Oral 24335959 disease of cellular proliferation DOID:0050866 miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. other hsa-mir-494 Squamous Cell Carcinoma, Oral 27399693 disease of cellular proliferation DOID:0050866 The overexpression of miR-494-3p in SAS cells increased the population of senescence-associated 尾-galactosidase positive cells, the expression of p16(INK4a) and retinoblastoma 1 (RB1), as well as downregulated Bmi1. other hsa-mir-9 Squamous Cell Carcinoma, Oral 29073835 disease of cellular proliferation DOID:0050866 miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway. other hsa-mir-135b Squamous Cell Carcinoma, Skin or Unspecific 25938461 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma. other hsa-mir-148a Squamous Cell Carcinoma, Skin or Unspecific 26253263 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 Role of miR-148a in cutaneous squamous cell carcinoma by repression of MAPK pathway. other hsa-mir-193b Squamous Cell Carcinoma, Skin or Unspecific 24374827 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. other hsa-mir-205 Squamous Cell Carcinoma, Skin or Unspecific 28013372 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. other hsa-mir-21 Squamous Cell Carcinoma, Skin or Unspecific 26029210 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 Conversely, small HA-CD44 interaction stimulates RhoA activation, NF魏B/Stat-3 signaling, and miR-21 production, resulting in inflammation and proliferation as well as SCC progression. other hsa-mir-21 Squamous Cell Carcinoma, Skin or Unspecific 22614019 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 These findings indicate that decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR-21 in squamous cell carcinoma of the skin. other hsa-mir-21 Squamous Cell Carcinoma, Skin or Unspecific 28013372 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. other hsa-mir-222 Squamous Cell Carcinoma, Skin or Unspecific 28925390 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes. other hsa-mir-365a Squamous Cell Carcinoma, Skin or Unspecific 24374827 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. other hsa-mir-490 Squamous Cell Carcinoma, Skin or Unspecific 27629145 disease of cellular proliferation DOID:3151 C44.92 HP:0006739 Poly r(C) binding protein is post-transcriptionally repressed by MiR-490-3p to potentiate squamous cell carcinoma. other hsa-mir-137 Squamous Cell Carcinoma, Tongue 27571935 disease of cellular proliferation DOID:0050865 C02.9 MicroRNA-137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion. other hsa-mir-149 Squamous Cell Carcinoma, Tongue 28356969 disease of cellular proliferation DOID:0050865 C02.9 MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility. other hsa-mir-183 Squamous Cell Carcinoma, Tongue 28281960 disease of cellular proliferation DOID:0050865 C02.9 miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line. other hsa-mir-203 Squamous Cell Carcinoma, Tongue 26946357 disease of cellular proliferation DOID:0050865 C02.9 miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer. other hsa-mir-21 Squamous Cell Carcinoma, Tongue 21426775 disease of cellular proliferation DOID:0050865 C02.9 Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] other hsa-mir-21 Squamous Cell Carcinoma, Tongue 26191145 disease of cellular proliferation DOID:0050865 C02.9 The role of miR-21 in proliferation and invasion capacity of human tongue squamous cell carcinoma in vitro. other hsa-mir-214 Squamous Cell Carcinoma, Tongue 25962755 disease of cellular proliferation DOID:0050865 C02.9 Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. other hsa-mir-23a Squamous Cell Carcinoma, Tongue 25501015 disease of cellular proliferation DOID:0050865 C02.9 the molecular mechanisms underlying TSCC chemoresistance. other hsa-mir-24 Squamous Cell Carcinoma, Tongue 28413152 disease of cellular proliferation DOID:0050865 C02.9 Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma. other hsa-mir-25 Squamous Cell Carcinoma, Tongue 23827155 disease of cellular proliferation DOID:0050865 C02.9 MiR-25-3p attenuates the proliferation of tongue squamous cell carcinoma cell line Tca8113. other hsa-mir-26a Squamous Cell Carcinoma, Tongue 24343426 disease of cellular proliferation DOID:0050865 C02.9 Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma. other hsa-mir-375 Squamous Cell Carcinoma, Tongue 27878285 disease of cellular proliferation DOID:0050865 C02.9 Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. other hsa-mir-424 Squamous Cell Carcinoma, Tongue 25965165 disease of cellular proliferation DOID:0050865 C02.9 Our patient data show that microRNA-424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell carcinoma. other hsa-mir-126 Status Epilepticus 29468563 nervous system disease DOID:1824 D013226 HP:0002133 the analysis of miRNA levels in serum could provide clinicians with a tool to evaluate disease evolution and the efficacy of α-T therapy in SE other hsa-mir-146a Status Epilepticus 29144992 nervous system disease DOID:1824 D013226 HP:0002133 Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus. other hsa-let-7f-1 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-let-7f-2 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-1-1 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-1-2 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-124 Stroke 23696548 I64 D020521 601367 HP:0001297 These data demonstrate that p53-mediated neuronal cell death after stroke can be nontranscriptionally regulated by a novel mechanism involving suppression of endogenous cell death inhibitors by miR-124. other hsa-mir-124 Stroke 23860031 I64 D020521 601367 HP:0001297 We highlight interactions between the miR-124 and the miR17-92 cluster and the Notch and Sonic hedgehog signaling pathways in mediating stroke-induced neurogenesis. other hsa-mir-124 Stroke 24244499 I64 D020521 601367 HP:0001297 miR-689, miR-124, and miR-155 were the most strongly associated miRNAs predicted to mediate pro-inflammatory pathways and M1-like activation phenotype. other hsa-mir-124 Stroke 27126323 I64 D020521 601367 HP:0001297 lithium increased miR-124 expression other hsa-mir-124 Stroke 27539642 I64 D020521 601367 HP:0001297 Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia. other hsa-mir-124 Stroke 28624203 I64 D020521 601367 HP:0001297 Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia. other hsa-mir-124 Stroke 29221142 I64 D020521 601367 HP:0001297 D-4F increases microRNA-124a and reduces neuroinflammation in diabetic stroke rats other hsa-mir-124 Stroke 29494665 I64 D020521 601367 HP:0001297 MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo other hsa-mir-124 Stroke 29524052 I64 D020521 601367 HP:0001297 this network-based approach to delineate miRNA, TF, and gene interactions might promote the development of effective therapeutics against ischemic stroke other hsa-mir-126 Stroke 28101763 I64 D020521 601367 HP:0001297 MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke. other hsa-mir-145 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-150 Stroke 26922365 I64 D020521 601367 HP:0001297 Upregulation of miR-150 expression could decrease vascular density of infarct border zone in rat after MCAO and decrease tube formation, proliferation, and migration of BMVECs. other hsa-mir-155 Stroke 24244499 I64 D020521 601367 HP:0001297 miR-155, the most strongly up-regulated miRNA,regulates the signal transducer and activator of transcription 3 signaling pathway enabling the late phase response to M1-skewing stimulation. other hsa-mir-155 Stroke 27829437 I64 D020521 601367 HP:0001297 In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. other hsa-mir-155 Stroke 28025572 I64 D020521 601367 HP:0001297 Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. other hsa-mir-155 Stroke 29527155 I64 D020521 601367 HP:0001297 the functions of the miRNA miR-155 and the effect of its in vivo inhibition on brain recovery following experimental cerebral ischemia other hsa-mir-181a-1 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-181a-2 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-185 Stroke 28199366 I64 D020521 601367 HP:0001297 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. other hsa-mir-19a Stroke 28199366 I64 D020521 601367 HP:0001297 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. other hsa-mir-20a Stroke 28199366 I64 D020521 601367 HP:0001297 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. other hsa-mir-210 Stroke 29111308 I64 D020521 601367 HP:0001297 Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. other hsa-mir-30a Stroke 28854438 I64 D020521 601367 HP:0001297 Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke. other hsa-mir-374b Stroke 28199366 I64 D020521 601367 HP:0001297 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. other hsa-mir-497 Stroke 23745809 I64 D020521 601367 HP:0001297 antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo. other hsa-mir-107 Stroke, Ischemic 24943094 I63.9 HP:0002140 Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke. other hsa-mir-149 Stroke, Ischemic 25867405 I63.9 HP:0002140 Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population. other hsa-mir-17 Synovial Sarcoma 24989082 disease of cellular proliferation DOID:5485 D013584 300813 HP:0012570 SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1. other hsa-let-7e Systemic Lupus Erythematosus 25912736 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 These data suggest that 17β-estradiol amplifies the activation of IFN-α signaling in B cells via IKKε by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE. other hsa-mir-101-1 Systemic Lupus Erythematosus 23139385 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus other hsa-mir-101-2 Systemic Lupus Erythematosus 23139385 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus other hsa-mir-142 Systemic Lupus Erythematosus 22549634 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Decreased miR-142-3p/5p expression causes CD4(+) T cell activation and B cell hyperstimulation in systemic lupus erythematosus. other hsa-mir-145a Systemic Lupus Erythematosus 25912736 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 These data suggest that 17β-estradiol amplifies the activation of IFN-α signaling in B cells via IKKε by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE. other hsa-mir-146a Systemic Lupus Erythematosus 21952984 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 miR-146a has a role in the pathogenesis of systemic lupus erythematosus with atherosclerosis. other hsa-mir-146a Systemic Lupus Erythematosus 24292724 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 STAT1 and miR-146a may be upregulated during inflammation and via proinflammatory cytokines and chemokines in SLE. Prolonged upregulation of STAT1 and miR-146a appears to play an important role in anemia in SLE patients. other hsa-mir-146a Systemic Lupus Erythematosus 25349113 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis : a meta-analysis. other hsa-mir-155 Systemic Lupus Erythematosus 26055806 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 We demonstrate that SLE patients have reduced IL-21 signaling capacity, decreased miR-155 levels, and increased SOCS1 levels compared to HCs.The reduced IL-21 signaling in SLE could be rescued by overexpression of miR-155,suggesting an important role for miR-155 in the reduced IL-21 signaling observed in SLE. other hsa-mir-155 Systemic Lupus Erythematosus 25929465 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 These findings provide new insight into the mechanism underlying decreased CD1d expression on B cells in SLE, suggesting that inhibition of inflammation may increase CD1d expression in B cells to ameliorate SLE via modulating iNKT cells. other hsa-mir-155 Systemic Lupus Erythematosus 27697141 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Follicular T helper cells and IL-21 in rheumatic diseases. other hsa-mir-155 Systemic Lupus Erythematosus 28665018 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals other hsa-mir-19b-1 Systemic Lupus Erythematosus 21794077 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. other hsa-mir-20a Systemic Lupus Erythematosus 21794077 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. other hsa-mir-21 Systemic Lupus Erythematosus 27697141 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Follicular T helper cells and IL-21 in rheumatic diseases. other hsa-mir-21 Systemic Lupus Erythematosus 28039018 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus. other hsa-mir-31 Systemic Lupus Erythematosus 22736314 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 microRNA-31 is a novel regulator contributing to impaired IL-2 production in T cells from patients with systemic lupus erythematosus. other hsa-mir-31 Systemic Lupus Erythematosus 27405090 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. other hsa-mir-34a Systemic Lupus Erythematosus 28665018 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals other hsa-mir-34b Systemic Lupus Erythematosus 28665018 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals other hsa-mir-7 Systemic Lupus Erythematosus 27450756 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 The clearest case is one circRNA CDR1as that serves as sponge of miR-7. other hsa-mir-98 Systemic Lupus Erythematosus 25912736 musculoskeletal system disease DOID:9074 M32.9 D008180 152700 HP:0002725 These data suggest that 17β-estradiol amplifies the activation of IFN-α signaling in B cells via IKKε by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE. other hsa-mir-142 Systemic Mastocytosis 24361879 hematopoietic system disease DOID:349 D47.2 D034721 154800 miR-142-3p enhances FcεRI-mediated degranulation in mast cells. other hsa-mir-124a Teratocarcinoma 17716626 disease of cellular proliferation DOID:3305 D018243 Based on these observations, it is suggested that the miR-302 cluster and miR-124a may be useful molecular indicators in the assessmentof degree of undifferentiation and/or differentiation in the course of neuronal differentiation. other hsa-mir-142 Testicular Germ Cell Tumor 23843459 disease of cellular proliferation DOID:5557 C563236 273300 Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA. other hsa-mir-302a Testicular Germ Cell Tumor 23625774 disease of cellular proliferation DOID:5557 C563236 273300 Up-regulation of miR-302a significantly increased the sensitivity of NT2 cells to cisplatin by enhancing cisplatin-induced G2/M phase arrest and the subsequent progression to apoptosis.MiR-302a also increased the killing effects of cisplatin by lowering the apoptotic threshold; the same result was also observed in another TGCT-derived cell line, NCCIT. other hsa-mir-371a Testicular Germ Cell Tumor 28612337 disease of cellular proliferation DOID:5557 C563236 273300 microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. other hsa-mir-133b Testicular Neoplasms 28126411 disease of cellular proliferation DOID:2998 D013736 273300 HP:0010788 Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes. other hsa-mir-372 Testicular Neoplasms 17965831 disease of cellular proliferation DOID:2998 D013736 273300 HP:0010788 miR-372 and miR-373 have been implicated in testicular germ cell tumours. other hsa-mir-373 Testicular Neoplasms 17965831 disease of cellular proliferation DOID:2998 D013736 273300 HP:0010788 miR-372 and miR-373 have been implicated in testicular germ cell tumours. other hsa-mir-940 Tetralogy Of Fallot 24889693 cardiovascular system disease DOID:6419 Q21.3 D013771 187500 miRNA-940 reduction contributes to human Tetralogy of Fallot development. other hsa-mir-145 Thrombocytosis 22571696 hematopoietic system disease DOID:2228 D69.6 D013922 HP:0001894 Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. other hsa-mir-146a Thrombocytosis 22571696 hematopoietic system disease DOID:2228 D69.6 D013922 HP:0001894 Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. other hsa-mir-326 Thrombosis 25875481 cardiovascular system disease DOID:0060903 D013927 The effect of miR-326 appeared to be limited to apoptosis,with no significant effect on platelet activation. These results provide new insight into the molecular mechanisms affecting differential platelet gene regulation, which may increase understanding of the role of platelet apoptosis in multiple diseases. other hsa-mir-101 Thyroid Adenomas 25916957 disease of cellular proliferation DOID:2891 D013964 611800 HP:0000854 These results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors. other hsa-mir-144 Thyroid Adenomas 25916957 disease of cellular proliferation DOID:2891 D013964 611800 HP:0000854 These results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors. other hsa-mir-126 Thyroid Neoplasms 26244545 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 To our knowledge, this is the first study to demonstrate that miR-126-3p has a tumor-suppressive function in thyroid cancer cells, and is associated with aggressive disease phenotype. other hsa-mir-126 Thyroid Neoplasms 27067785 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma. other hsa-mir-144 Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-146b Thyroid Neoplasms 23264400 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Prognostic Implications of miR-146b Expression and Its Functional Role in Papillary Thyroid Carcinoma other hsa-mir-146b Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-197 Thyroid Neoplasms 22351693 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign. other hsa-mir-205 Thyroid Neoplasms 26342107 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 The angiogenic and tumour-suppressive roles of miRNA-205 were demonstrated for the first time in thyroid cancer. The current experiments provided specific information on the functional consequences of VEGF manipulation via miRNA on cancer. other hsa-mir-206 Thyroid Neoplasms 25955685 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 miR-206 inhibits metastasis-relevant traits by degrading MRTF-A in anaplastic thyroid cancer. other hsa-mir-21 Thyroid Neoplasms 22351693 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign. other hsa-mir-221 Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-221 Thyroid Neoplasms 22771635 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 While a combination of miR-221 and 222 when used in a diagnostic panel could provide fairly good accuracy additional markers may need to be investigated to augment their diagnostic utility. other hsa-mir-222 Thyroid Neoplasms 22351693 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign. other hsa-mir-222 Thyroid Neoplasms 22771635 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 While a combination of miR-221 and 222 when used in a diagnostic panel could provide fairly good accuracy additional markers may need to be investigated to augment their diagnostic utility. other hsa-mir-25 Thyroid Neoplasms 26437444 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway. other hsa-mir-30d Thyroid Neoplasms 24345332 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. other hsa-mir-328 Thyroid Neoplasms 22351693 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign. other hsa-mir-371a Thyroid Neoplasms 23062364 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Activation of the two microRNA clusters C19MC and miR-371-3 does not play prominent role in thyroid cancer other hsa-mir-4295 Thyroid Neoplasms 26231799 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A. other hsa-mir-486 Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-551b Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-618 Thyroid Neoplasms 25145559 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 MiR-618 inhibits anaplastic thyroid cancer by repressing XIAP in one ATC cell line. other hsa-mir-7 Thyroid Neoplasms 23783103 disease of cellular proliferation DOID:1781 C73 D013964 188550 HP:0100031 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. other hsa-mir-210 Tibial Meniscus Injuries 25430980 D000070600 An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. other hsa-mir-195 Tongue Neoplasms 23451060 gastrointestinal system disease DOID:8649 C01 D014062 HP:0100648 Prognostic Implications of MicoRNA miR-195 Expression in Human Tongue Squamous Cell Carcinoma other hsa-mir-375 Tongue Neoplasms 25521291 gastrointestinal system disease DOID:8649 C01 D014062 HP:0100648 the four anti-cancer drugs examined in this study induce the expression of tumor suppressor miR-375 in tongue cancer. other hsa-mir-34a Toxic Encephalopathy 26091620 nervous system disease DOID:3602 G92 D020258 We also found that inhibition of astrocytic miR-34a after Lipopolysaccharide(LPS) stimulation can postpone dopaminergic neuron loss under neurotoxin stress. other hsa-mir-34a Toxic Encephalopathy 29578002 nervous system disease DOID:3602 G92 D020258 microRNA-34a could improve anesthesia-induced cognitive dysfunction by suppressing cell apoptosis and recovering the expression of genes associated with the MAPK/ERK signaling pathway other hsa-mir-106b Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-132 Toxoplasma gondii Infection 24657774 disease by infectious agent DOID:9965 B58 D014123 MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. other hsa-mir-146a Toxoplasma gondii Infection 24582962 disease by infectious agent DOID:9965 B58 D014123 miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. other hsa-mir-155 Toxoplasma gondii Infection 24582962 disease by infectious agent DOID:9965 B58 D014123 miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. other hsa-mir-17 Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-17 Toxoplasma gondii Infection 24583285 disease by infectious agent DOID:9965 B58 D014123 Taken together, we describe a novel STAT3-miR-17-92-Bim pathway, thus providing a mechanistic explanation for inhibition of apoptosis of host cells following Toxoplasma infection. other hsa-mir-17 Toxoplasma gondii Infection 24341525 disease by infectious agent DOID:9965 B58 D014123 We demonstrated that miR-30c-1, miR-125b-2, miR-23b-27b-24-1 and miR-17鈥墌鈥?2 cluster genes were transactivated through promoter binding of the STAT3 following T. gondii infection. other hsa-mir-18a Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-19a Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-19b-1 Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-19b-2 Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-20a Toxoplasma gondii Infection 20090903 disease by infectious agent DOID:9965 B58 D014123 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases other hsa-mir-223 Traumatic Brain Injury 28804446 S06.2 D000070642 Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect. other hsa-mir-125b Tuberculosis 27789724 disease by infectious agent DOID:399 A15-A19 D014376 Downregulation of hsa-miR-337-3p and hsa-miR-125b-5p by miRNA sponges improved IL-23-mediated expansion of Vγ2Vδ2 T cells and restored the ability of these cells to produce anti-tuberculosis cytokines other hsa-mir-337 Tuberculosis 27789724 disease by infectious agent DOID:399 A15-A19 D014376 Downregulation of hsa-miR-337-3p and hsa-miR-125b-5p by miRNA sponges improved IL-23-mediated expansion of Vγ2Vδ2 T cells and restored the ability of these cells to produce anti-tuberculosis cytokines other hsa-mir-144 Tuberculosis, Pulmonary 21367459 disease by infectious agent DOID:2957 A15 D014397 Modulation of T cell cytokine production by miR-144* with elevated expression in patients with pulmonary tuberculosis. other hsa-mir-29a Tuberculosis, Pulmonary 24981709 disease by infectious agent DOID:2957 A15 D014397 Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. other hsa-mir-100 Urinary Bladder Cancer 25071007 urinary system disease DOID:11054 C67 D001749 109800 microRNAs-99a/100 mediate a direct relationship between FGFR3 and FOXA1 and potentially facilitate cross talk between these pathways in UCC. other hsa-mir-133a-1 Urinary Bladder Cancer 23410519 urinary system disease DOID:11054 C67 D001749 109800 A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells other hsa-mir-133b Urinary Bladder Cancer 22179829 urinary system disease DOID:11054 C67 D001749 109800 MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways. other hsa-mir-138-1 Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. other hsa-mir-138-2 Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. other hsa-mir-139 Urinary Bladder Cancer 23410519 urinary system disease DOID:11054 C67 D001749 109800 A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells other hsa-mir-142 Urinary Bladder Cancer 23410519 urinary system disease DOID:11054 C67 D001749 109800 A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells other hsa-mir-143 Urinary Bladder Cancer 19157460 urinary system disease DOID:11054 C67 D001749 109800 miR-143: a tumor suppressor other hsa-mir-143 Urinary Bladder Cancer 21550168 urinary system disease DOID:11054 C67 D001749 109800 MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells other hsa-mir-145 Urinary Bladder Cancer 22287315 urinary system disease DOID:11054 C67 D001749 109800 Glucocorticoid regulation of a novel HPV E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells. other hsa-mir-182 Urinary Bladder Cancer 25676538 urinary system disease DOID:11054 C67 D001749 109800 This study shows that the level of miR-182 is higher in cytology specimens from high-grade UCC patients as compared to normal controls.Measuring miR-182 may provide a potential alternative or adjunct approach for screening high-grade UCC. other hsa-mir-182 Urinary Bladder Cancer 23313739 urinary system disease DOID:11054 C67 D001749 109800 MicroRNA-182 plays an onco-miRNA role in cervical cancer other hsa-mir-194-1 Urinary Bladder Cancer 17470785 urinary system disease DOID:11054 C67 D001749 109800 The list of miRNAs at or near sites commonly altered in human cancers includes mir-215 and mir-194-1, which are <0.17 kb from D1Mit208, a marker that defines the peak of the colon Scc3 locus on Chr 1. Homologous human miRNAs are located inside the FRA1H at Chr 1q42.1; this fragile site is an HPV16 integration site involved in cervical cancer. other hsa-mir-200a Urinary Bladder Cancer 20124485 urinary system disease DOID:11054 C67 D001749 109800 play important regulatory roles in cervical cancer control other hsa-mir-203 Urinary Bladder Cancer 21836020 urinary system disease DOID:11054 C67 D001749 109800 Curcumin modulates microRNA-203 mediated regulation of the Src-Akt axis in bladder cancer. other hsa-mir-205 Urinary Bladder Cancer 23056551 urinary system disease DOID:11054 C67 D001749 109800 miR-205 expression promotes cell proliferation and migration of human cervical cancer cells other hsa-mir-21 Urinary Bladder Cancer 21468550 urinary system disease DOID:11054 C67 D001749 109800 microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells other hsa-mir-215 Urinary Bladder Cancer 17470785 urinary system disease DOID:11054 C67 D001749 109800 The list of miRNAs at or near sites commonly altered in human cancers includes mir-215 and mir-194-1, which are <0.17 kb from D1Mit208, a marker that defines the peak of the colon Scc3 locus on Chr 1. Homologous human miRNAs are located inside the FRA1H at Chr 1q42.1; this fragile site is an HPV16 integration site involved in cervical cancer. other hsa-mir-218-1 Urinary Bladder Cancer 23443110 urinary system disease DOID:11054 C67 D001749 109800 MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer other hsa-mir-218-2 Urinary Bladder Cancer 23443110 urinary system disease DOID:11054 C67 D001749 109800 MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer other hsa-mir-23b Urinary Bladder Cancer 21242962 urinary system disease DOID:11054 C67 D001749 109800 Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. other hsa-mir-27 Urinary Bladder Cancer 24821854 urinary system disease DOID:11054 C67 D001749 109800 3'-Biotin-tagged microRNA-27 does not associate with Argonaute proteins in cells. other hsa-mir-27a Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. other hsa-mir-34a Urinary Bladder Cancer 21702042 urinary system disease DOID:11054 C67 D001749 109800 MiR-34a chemo-sensitizes bladder cancer cells to cisplatin treatment regardless of P53-Rb pathway status. other hsa-mir-34a Urinary Bladder Cancer 19258450 urinary system disease DOID:11054 C67 D001749 109800 miR-34a: Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6 other hsa-mir-517a Urinary Bladder Cancer 21479368 urinary system disease DOID:11054 C67 D001749 109800 Restoration of miR-517a expression induces cell apoptosis in bladder cancer cell lines. other hsa-mir-574 Urinary Bladder Cancer 22179486 urinary system disease DOID:11054 C67 D001749 109800 Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. other hsa-mir-642a Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. other hsa-mir-642b Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. other hsa-mir-93 Urinary Bladder Cancer 19671845 urinary system disease DOID:11054 C67 D001749 109800 control the EMT process and sensitivity to EGFR therapy other hsa-mir-944 Urinary Bladder Cancer 22954303 urinary system disease DOID:11054 C67 D001749 109800 Three miRNAs were associated with both response (to chemotherapy) and survival (886-3p, 923, 944). other hsa-mir-99a Urinary Bladder Cancer 25071007 urinary system disease DOID:11054 C67 D001749 109800 microRNAs-99a/100 mediate a direct relationship between FGFR3 and FOXA1 and potentially facilitate cross talk between these pathways in UCC. other hsa-mir-29b Uterine Corpus Choriocarcinoma 25738313 disease of cellular proliferation DOID:8188 C54.9 BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression. other hsa-mir-182 Uterine Leiomyoma 24476133 D25.9 D007889 150699 HP:0000131 We observed that administration of MK-2206, an allosteric AKT inhibitor, increased levels of reactive oxygen species, up-regulated the microRNA miR-182 and several senescence-associated genes (including p16, p53, p21, and 尾-galactosidase), and drove leiomyoma cells into stress-induced premature senescence (SIPS). other hsa-mir-29b Uterine Leiomyoma 24424054 D25.9 D007889 150699 HP:0000131 Down-regulation of miR-29b is essential for pathogenesis of uterine leiomyoma. other hsa-mir-144 Uveal Melanoma 25961751 C536494 155720 HP:0007716 MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression. other hsa-mir-454 Uveal Melanoma 26296312 C536494 155720 HP:0007716 Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma. other hsa-let-7f Vascular Disease [unspecific] 18550634 cardiovascular system disease DOID:178 I72.9 D000783 Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs other hsa-mir-125a Vascular Disease [unspecific] 25854878 cardiovascular system disease DOID:178 I72.9 D000783 These translational data emphasize the pathogenetic role of miR-125a in pulmonary vascular remodeling. other hsa-mir-126 Vascular Disease [unspecific] 19917099 cardiovascular system disease DOID:178 I72.9 D000783 miR-126, miR-24 and miR-23a are selectively expressed in microvascular endothelial cells in vivo other hsa-mir-126 Vascular Disease [unspecific] 20364122 cardiovascular system disease DOID:178 I72.9 D000783 We further find that angiogenic sprouting of AA vessels requires a flow-induced genetic pathway in which the mechano-sensitive zinc finger transcription factor klf2a induces expression of an endothelial-specific microRNA, mir-126, to activate Vegf signalling. other hsa-mir-126 Vascular Disease [unspecific] 27780851 cardiovascular system disease DOID:178 I72.9 D000783 GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Hence, modulation of GATA2 and its targets miR-126 and miR-221 is a promising therapeutic strategy for treatment of many vascular diseases other hsa-mir-130a Vascular Disease [unspecific] 18550634 cardiovascular system disease DOID:178 I72.9 D000783 Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs other hsa-mir-143 Vascular Disease [unspecific] 25655189 cardiovascular system disease DOID:178 I72.9 D000783 Myocyte Enhancer Factor 2A Regulates Hydrogen Peroxide-Induced Senescence of Vascular Smooth Muscle Cells Via microRNA-143. other hsa-mir-145 Vascular Disease [unspecific] 19917099 cardiovascular system disease DOID:178 I72.9 D000783 elevated levels of miR-145 reduced migration of microvascular cells in response to growth factor gradients in vitro other hsa-mir-145 Vascular Disease [unspecific] 25655189 cardiovascular system disease DOID:178 I72.9 D000783 Myocyte Enhancer Factor 2A Regulates Hydrogen Peroxide-Induced Senescence of Vascular Smooth Muscle Cells Via microRNA-143. other hsa-mir-145 Vascular Disease [unspecific] 27186305 cardiovascular system disease DOID:178 I72.9 D000783 MicroRNA-145 regulates platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration by targeting CD40 other hsa-mir-15b Vascular Disease [unspecific] 25665638 cardiovascular system disease DOID:178 I72.9 D000783 We focus on the diverse roles of miR-15b in the occurrence, progression and prognosis of vascular diseases,with particular emphasis on preeclampsia, a hypertensive disorder related to endovascular dysfunction in the placenta. other hsa-mir-16 Vascular Disease [unspecific] 29402872 cardiovascular system disease DOID:178 I72.9 D000783 This revascularization is associated with a decrease in miRNA-16 expression permissive for increased VEGF protein expression, suggesting a mechanism for potential therapeutic application in vascular diseases other hsa-mir-181a Vascular Disease [unspecific] 27911586 cardiovascular system disease DOID:178 I72.9 D000783 miRNA-181a/b Regulates Phenotypes of Vessel Smooth Muscle Cells Through Serum Response Factor. other hsa-mir-181b Vascular Disease [unspecific] 27911586 cardiovascular system disease DOID:178 I72.9 D000783 miRNA-181a/b Regulates Phenotypes of Vessel Smooth Muscle Cells Through Serum Response Factor. other hsa-mir-22 Vascular Disease [unspecific] 25530680 cardiovascular system disease DOID:178 I72.9 D000783 Mox-LDL interferes with parameters associated with angiogenesis. They suggest that high LDL levels in patients would impair their endothelial cell capacity to cope with a damaged endothelium contributing negatively to the progression of the atheroma plaque. other hsa-mir-221 Vascular Disease [unspecific] 27780851 cardiovascular system disease DOID:178 I72.9 D000783 GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Hence, modulation of GATA2 and its targets miR-126 and miR-221 is a promising therapeutic strategy for treatment of many vascular diseases other hsa-mir-23a Vascular Disease [unspecific] 19917099 cardiovascular system disease DOID:178 I72.9 D000783 miR-126, miR-24 and miR-23a are selectively expressed in microvascular endothelial cells in vivo other hsa-mir-24 Vascular Disease [unspecific] 20019669 cardiovascular system disease DOID:178 I72.9 D000783 Inhibition of miR-24 by antisense oligonuclotides abrogates the downregulation of Trb3 as well as pro-synthetic activity of the PDGF-signalling pathway. other hsa-mir-27b Vascular Disease [unspecific] 18550634 cardiovascular system disease DOID:178 I72.9 D000783 Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs other hsa-mir-29a Vascular Disease [unspecific] 27752152 cardiovascular system disease DOID:178 I72.9 D000783 Dynamic alteration of microRNA in high phosphorus induced calcification of vascular smooth muscle cell. other hsa-mir-30b Vascular Disease [unspecific] 23316327 cardiovascular system disease DOID:178 I72.9 D000783 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification other hsa-mir-30c-1 Vascular Disease [unspecific] 23316327 cardiovascular system disease DOID:178 I72.9 D000783 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification other hsa-mir-30c-2 Vascular Disease [unspecific] 23316327 cardiovascular system disease DOID:178 I72.9 D000783 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification other hsa-mir-34a Vascular Disease [unspecific] 26582729 cardiovascular system disease DOID:178 I72.9 D000783 overexpression of a miR-34a mimic prevents metformin-mediated protection. other hsa-mir-483 Vascular Disease [unspecific] 24976017 cardiovascular system disease DOID:178 I72.9 D000783 Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system. other hsa-let-7a Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7b Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7b Vascular Disease [unspecific] 26348824 cardiovascular system disease DOID:178 I72.9 D000783 only let-7b and miR-133a were markedly upregulated. other hsa-let-7c Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7d Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7e Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7f Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7g Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-let-7i Vascular Disease [unspecific] 17540974 cardiovascular system disease DOID:178 I72.9 D000783 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. other hsa-mir-126 Vascular Disease [unspecific] 27789478 cardiovascular system disease DOID:178 I72.9 D000783 MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. other hsa-mir-155 Vascular Disease [unspecific] 17293455 cardiovascular system disease DOID:178 I72.9 D000783 As predicted, miRNA-155 transduction greatly reduced both myeloid and erythroid colony formation of normal human HSPCs. other hsa-mir-21 Vascular Disease [unspecific] 28707876 cardiovascular system disease DOID:178 I72.9 D000783 Fluorescence Light-Up Biosensor for MicroRNA Based on the Distance-Dependent Photoinduced Electron Transfer. other hsa-mir-21 Vascular Disease [unspecific] 29456377 cardiovascular system disease DOID:178 I72.9 D000783 the stability of both DIM and pre-miR-22 was found to be inversely correlated to each other in binding condition other hsa-mir-21 Vascular Disease [unspecific] 29659130 cardiovascular system disease DOID:178 I72.9 D000783 MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease other hsa-mir-221 Vascular Disease [unspecific] 19351599 cardiovascular system disease DOID:178 I72.9 D000783 MicroRNA-221 regulates high glucose-induced endothelial dysfunction other hsa-mir-23a Vascular Disease [unspecific] 28662151 cardiovascular system disease DOID:178 I72.9 D000783 Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction. other hsa-mir-92a Vascular Disease [unspecific] 28662151 cardiovascular system disease DOID:178 I72.9 D000783 Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction. other hsa-let-7a Vascular Hypertrophy 28187784 Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling. other hsa-mir-1 Vascular Hypertrophy 23711953 the muscle-specific miR-1 and miR-133 are involved in cardiac development and hypertrophy other hsa-mir-1 Vascular Hypertrophy 23859766 In addition, microRNAs (miR) -133a, miR-208 and miR-1 which were elevated following high-fat feeding were attenuated by apelin treatment. other hsa-mir-1 Vascular Hypertrophy 27056419 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential other hsa-mir-1 Vascular Hypertrophy 28114137 Hydrogen Sulfide Protects Cardiomyocytes against Apoptosis in Ischemia/Reperfusion through MiR-1-Regulated Histone Deacetylase 4 Pathway. other hsa-mir-1 Vascular Hypertrophy 23691029 The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis. other hsa-mir-133a Vascular Hypertrophy 23493786 Our study unraveled for the first time the cardioprotection of choline against cardiac hypertrophy, with correction of expression of miR-133a and calcineurin as a possible mechanism. other hsa-mir-133a Vascular Hypertrophy 27056419 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential. other hsa-mir-133a Vascular Hypertrophy 28526870 these c-miRNAs may serve as markers for monitoring the RT responses other hsa-mir-206 Vascular Hypertrophy 18381085 The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle. other hsa-mir-206 Vascular Hypertrophy 27789288 Bladder overactivity involves overexpression of MicroRNA 132 and nerve growth factor. other hsa-mir-208 Vascular Hypertrophy 23859766 In addition, microRNAs (miR) -133a, miR-208 and miR-1 which were elevated following high-fat feeding were attenuated by apelin treatment. other hsa-mir-208 Vascular Hypertrophy 25840809 miR-208 family is closely associated with the development of cardiac diseases other hsa-mir-208 Vascular Hypertrophy 27056419 miR-208/499 located in introns of the heavy chain myosin genes regulate expression of sarcomeric contractile proteins. other hsa-mir-21 Vascular Hypertrophy 25689721 Ursolic acid down-regulated miRNA-21 expression and up-regulated PTEN protein and mRNA expression. other hsa-mir-21 Vascular Hypertrophy 25903305 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. other hsa-mir-21 Vascular Hypertrophy 27160852 Celastrol also inhibited the miR-21/ERK signalling pathway. other hsa-mir-21 Vascular Hypertrophy 27542393 MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation. other hsa-mir-21 Vascular Hypertrophy 28368454 Role and Regulation of MicroRNAs in Aldosterone-Mediated Cardiac Injury and Dysfunction in Male Rats. other hsa-mir-21 Vascular Hypertrophy 28465975 Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling. other hsa-mir-21 Vascular Hypertrophy 28526870 these c-miRNAs may serve as markers for monitoring the RT responses other hsa-mir-21 Vascular Hypertrophy 23691029 The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis. other hsa-mir-29a Vascular Hypertrophy 25308856 Effect of miR-29a inhibition on ventricular hypertrophy induced by pressure overload. other hsa-mir-100 Vascular Injuries 27622243 D057772 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. other hsa-mir-147 Vascular Injuries 27622243 D057772 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. other hsa-mir-181 Vascular Injuries 28316180 D057772 Effect and related mechanism of microRNA-181 attenuates oxidized low density lipoprotein induced vascular endothelial cell injury. other hsa-mir-21 Vascular Injuries 27622243 D057772 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. other hsa-mir-222 Vascular Injuries 27622243 D057772 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. other hsa-mir-27a Vascular Injuries 27622243 D057772 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. other hsa-mir-122 Viral Infectious Disease 25265013 disease by infectious agent DOID:934 A94 D001102 MiR-122 directly inhibits human papillomavirus E6 gene and enhances interferon signaling through blocking suppressor of cytokine signaling 1 in SiHa cells. other hsa-mir-200 Viral Infectious Disease 24599990 disease by infectious agent DOID:934 A94 D001102 Host microRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency. other hsa-mir-2909 Viral Infectious Disease 24361962 disease by infectious agent DOID:934 A94 D001102 Arsenic programmes cellular genomic-immunity through miR-2909 RNomics. other hsa-mir-32 Viral Infectious Disease 17096367 disease by infectious agent DOID:934 A94 D001102 The authors found that a cellular miRNA, miR-32, mediated antiviral defense in human cells, and regulated primate foamy virus type I (PFV-1) proliferation. other hsa-mir-376a Viral Infectious Disease 24586166 disease by infectious agent DOID:934 A94 D001102 MicroRNA editing facilitates immune elimination of HCMV infected cells. other hsa-mir-485 Viral Infectious Disease 26645583 disease by infectious agent DOID:934 A94 D001102 These findings highlight the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection. other hsa-mir-7 Viral Infectious Disease 26067353 disease by infectious agent DOID:934 A94 D001102 Results of this study identify a molecular mechanism of RNAi for antiviral defense, and extend our knowledge of the complex interplay between host and PV, which will provide a basis for the development of effective RNAi-based therapies designed to inhibit PV replication and protect host cells. other hsa-mir-9 Viral Infectious Disease 24109243 disease by infectious agent DOID:934 A94 D001102 Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation. other hsa-mir-92a Viral Infectious Disease 24518554 disease by infectious agent DOID:934 A94 D001102 Reply to Shin and Bayry on An age-related decline of CD62L and vaccine response: a role of microRNA 92a. other hsa-mir-93 Viral Infectious Disease 25858415 disease by infectious agent DOID:934 A94 D001102 Generation of a safe and effective live viral vaccine by virus self-attenuation using species-specific artificial microRNA. other hsa-mir-1 Viral Myocarditis 27997912 B33.2 D009205 Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-α, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children. other hsa-mir-146b Viral Myocarditis 27997912 B33.2 D009205 Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-α, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children. other hsa-mir-221 Viral Myocarditis 26206211 B33.2 D009205 The miR-221/-222 cluster orchestrates the antiviral and inflammatory immune response to viral infection of the heart. Its inhibition increases viral load, inflammation, and overall cardiac injury upon VM. other hsa-mir-222 Viral Myocarditis 26206211 B33.2 D009205 The miR-221/-222 cluster orchestrates the antiviral and inflammatory immune response to viral infection of the heart. Its inhibition increases viral load, inflammation, and overall cardiac injury upon VM. other hsa-mir-100 Vulvar Squamous Cell Carcinoma 24048714 disease of cellular proliferation DOID:2101 In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. other hsa-mir-133a Vulvar Squamous Cell Carcinoma 24048714 disease of cellular proliferation DOID:2101 In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. other hsa-mir-19b-1 Vulvar Squamous Cell Carcinoma 24048714 disease of cellular proliferation DOID:2101 In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. other hsa-mir-223 Vulvar Squamous Cell Carcinoma 24048714 disease of cellular proliferation DOID:2101 In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. other hsa-mir-519b Vulvar Squamous Cell Carcinoma 24048714 disease of cellular proliferation DOID:2101 In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer. other hsa-mir-155 Waldenstrom Macroglobulinemia 22122052 C88.0 D008258 153600 HP:0005508 Among deregulated miRNAs, miR-155 and miR-9* play a pivotal role in the pathogenesis of this disease. other hsa-mir-155 Waldenstrom Macroglobulinemia 23048077 C88.0 D008258 153600 HP:0005508 Importantly, everolimus targeted Waldenstrom macroglobulinemia cells even in the context of bone marrow milieu, where it affected migration, adhesion, and angiogenesis.Everolimus-dependent anti-Waldenstrom macroglobulinemia activity was partially driven by miRNA-155. other hsa-mir-9 Waldenstrom Macroglobulinemia 22122052 C88.0 D008258 153600 HP:0005508 Among deregulated miRNAs, miR-155 and miR-9* play a pivotal role in the pathogenesis of this disease. other hsa-mir-126 White Spot Syndrome Virus Infection 27825947 D046848 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. other hsa-mir-184 White Spot Syndrome Virus Infection 27825947 D046848 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. other hsa-mir-7 White Spot Syndrome Virus Infection 27825947 D046848 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. other hsa-let-7 Wilms Tumor 27647875 C64.2 D009396 PS194070 HP:0002667 uridylated pre-let-7 miRNAs and mRNAs are targeted by the 3' to 5' exoribonuclease DIS3L2 other hsa-mir-193a Wilms Tumor 29357419 C64.2 D009396 PS194070 HP:0002667 Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu. other hsa-mir-19b Wilms Tumor 28322459 C64.2 D009396 PS194070 HP:0002667 Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway. other hsa-mir-743a Wilms Tumor 27667021 C64.2 D009396 PS194070 HP:0002667 Proliferation of metanephric mesenchymal cells is inhibited by miR-743a-mediated WT1 suppression in vitro. other hsa-mir-125b Wound Healing 27388239 D014945 HP:0001058 the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess 伪-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-尾/SMAD2 signaling pathway. other hsa-mir-1285 Wound Healing 28175294 D014945 HP:0001058 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. other hsa-mir-142 Wound Healing 27894934 D014945 HP:0001058 MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton. other hsa-mir-145 Wound Healing 27388239 D014945 HP:0001058 the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess 伪-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-尾/SMAD2 signaling pathway. other hsa-mir-147b Wound Healing 28175294 D014945 HP:0001058 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. other hsa-mir-155 Wound Healing 28175294 D014945 HP:0001058 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. other hsa-mir-184 Wound Healing 28175294 D014945 HP:0001058 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. other hsa-mir-18a Wound Healing 27390086 D014945 HP:0001058 We found miR-18a was most susceptible to SH treatment, the target prediction of which were enriched in a bunch of pathways implicated in corneal wound healing. other hsa-mir-21 Wound Healing 27388239 D014945 HP:0001058 the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess 伪-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-尾/SMAD2 signaling pathway. other hsa-mir-23a Wound Healing 27388239 D014945 HP:0001058 the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess 伪-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-尾/SMAD2 signaling pathway. other hsa-mir-29b Wound Healing 28092445 D014945 HP:0001058 miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-β1/Smad/CTGF signaling pathway. other hsa-mir-31 Wound Healing 29605672 D014945 HP:0001058 these findings identify miR-31 as an important cell-autonomous mediator during the transition from inflammation to re-epithelialization phases of wound healing, suggesting a therapeutic potential for miR-31 in skin injury repair other hsa-mir-146a Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. other hsa-mir-181 Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. other hsa-mir-21 Wound Inflammation 24391209 Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation. other hsa-mir-21 Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. other hsa-mir-132 Wounds and Injuries [unspecific] 26121747 D014947 MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. other hsa-mir-21 Wounds and Injuries [unspecific] 21647251 D014947 miR-21 promotes keratinocyte migration and re-epithelialization during wound healing. other hsa-mir-31 Wounds and Injuries [unspecific] 25685928 D014947 MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration. other hsa-mir-483 Wounds and Injuries [unspecific] 21676945 D014947 miR-483-3p controls proliferation in wounded epithelial cells.